id category name description provided_by synonym 0000233 0000589 0100001 comment consider created_by creation_date default_namespace deprecated has_alternative_id has_db_xref has_o_b_o_format_version has_o_b_o_namespace is_class_level is_metadata_tag knowledge_source license logical_interpretation object predicate relation shorthand subject type version
GO:0009590 biolink:NamedThing detection of gravity The series of events in which a gravitational stimulus is received and converted into a molecular signal. got7fsn_ti perception of gravity biological_process owl:Class
GO:0009582 biolink:NamedThing detection of abiotic stimulus The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of abiotic stimulus biological_process owl:Class
GO:0048282 biolink:NamedThing determinate inflorescence morphogenesis The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can only produce a predetermined number of floral meristems. got7fsn_ti biological_process owl:Class
GO:0048281 biolink:NamedThing inflorescence morphogenesis The process in which the anatomical structures of inflorescences are generated and organized. An inflorescence is the part of a seed plant body that is usually above ground and that can bear flowers. got7fsn_ti biological_process owl:Class
GO:0007319 biolink:NamedThing negative regulation of oskar mRNA translation Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein. got7fsn_ti down-regulation of oskar mRNA translation|downregulation of oskar mRNA translation|down regulation of oskar mRNA translation|inhibition of oskar mRNA translation biological_process owl:Class
GO:0046011 biolink:NamedThing regulation of oskar mRNA translation Any process that modulates the frequency, rate or extent of oskar mRNA translation. To ensure the localization of Oskar protein at the posterior pole of the oocyte, translation of oskar mRNA is repressed during its transport to the posterior pole and activated upon localization of the mRNA at the posterior cortex. got7fsn_ti biological_process owl:Class
GO:0043909 biolink:NamedThing N-acetylcitrulline deacetylase activity Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate. got7fsn_ti acetylcitrulline deacetylase activity|N-acetyl-L-citrulline deacetylase activity RHEA:61092 molecular_function owl:Class
GO:0016811 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. got7fsn_ti Reactome:R-HSA-9673054|Reactome:R-HSA-9673053|EC:3.5.1.- molecular_function owl:Class
GO:0048523 biolink:NamedThing negative regulation of cellular process Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. got7fsn_ti inhibition of cellular process|down regulation of cellular process|negative regulation of cellular physiological process|down-regulation of cellular process|downregulation of cellular process GO:0051243 biological_process owl:Class
GO:0050794 biolink:NamedThing regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. got7fsn_ti regulation of cellular physiological process GO:0051244 biological_process owl:Class
GO:0018647 biolink:NamedThing phenanthrene 1,2-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide. got7fsn_ti UM-BBD_enzymeID:e0333|EC:1.14.13.- molecular_function owl:Class
GO:0016709 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen Reactome:R-HSA-2162187|Reactome:R-HSA-2162194|EC:1.14.13.- molecular_function owl:Class
GO:0071241 biolink:NamedThing cellular response to inorganic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. got7fsn_ti mah 2009-12-03T02:35:49Z biological_process owl:Class
GO:0010035 biolink:NamedThing response to inorganic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus. got7fsn_ti biological_process owl:Class
GO:0005723 biolink:NamedThing alpha-heterochromatin A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization. got7fsn_ti cellular_component owl:Class
GO:0005721 biolink:NamedThing pericentric heterochromatin Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3. got7fsn_ti nuclear cluster|centromeric heterochromatin|nuclear centric heterochromatin|nuclear pericentric heterochromatin|centric heterochromatin GO:0031618|GO:0002137 cellular_component owl:Class
GO:0046527 biolink:NamedThing glucosyltransferase activity Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. got7fsn_ti molecular_function owl:Class
GO:0016758 biolink:NamedThing hexosyltransferase activity Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring hexosyl groups EC:2.4.1.- molecular_function owl:Class
GO:0019046 biolink:NamedThing release from viral latency The process by which a virus begins to replicate following a latency replication decision (switch). got7fsn_ti GO:0075717 biological_process owl:Class
GO:0016032 biolink:NamedThing viral process A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. got7fsn_ti viral infection|virulence|virus process See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. GO:0022415 Wikipedia:Viral_life_cycle biological_process owl:Class
GO:0043545 biolink:NamedThing molybdopterin cofactor metabolic process The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. got7fsn_ti Moco metabolic process|Moco metabolism|molybdopterin cofactor metabolism biological_process owl:Class
GO:0051189 biolink:NamedThing prosthetic group metabolic process The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. got7fsn_ti prosthetic group metabolism|coenzyme and prosthetic group metabolic process|coenzyme and prosthetic group metabolism biological_process owl:Class
GO:0047187 biolink:NamedThing deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase activity Catalysis of the reaction: deacetyl-[citrate-oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + S-acetylphosphopantetheine = [citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)-acetate)] + pantetheine 4'-phosphate. got7fsn_ti deacetyl-citrate-(pro-3S)-lyase S-acetyltransferase activity|S-acetylphosphopantetheine:deacetyl-citrate-oxaloacetate-lyase((pro-3S)-CH2COO-rightacetate)S-acetyltransferase activity|deacetyl-citrate-(pro-3S)-lyase acetyltransferase activity|S-acetyl phosphopantetheine:deacetyl citrate lyase S-acetyltransferase activity EC:2.3.1.49|MetaCyc:2.3.1.49-RXN|RHEA:20393 molecular_function owl:Class
GO:0140096 biolink:NamedThing catalytic activity, acting on a protein Catalytic activity that acts to modify a protein. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-14T10:32:59Z molecular_function owl:Class
GO:0021915 biolink:NamedThing neural tube development The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium. got7fsn_ti biological_process owl:Class
GO:0032502 biolink:NamedThing developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. got7fsn_ti development|single-organism developmental process jl 2012-12-19T12:21:31Z GO:0044767 biological_process owl:Class
GO:0031853 biolink:NamedThing nociceptin receptor binding Binding to a nociceptin receptor. got7fsn_ti nociceptin receptor ligand molecular_function owl:Class
GO:0031628 biolink:NamedThing opioid receptor binding Binding to an opioid receptor. got7fsn_ti molecular_function owl:Class
GO:0042550 biolink:NamedThing photosystem I stabilization The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. got7fsn_ti biological_process owl:Class
GO:0042548 biolink:NamedThing regulation of photosynthesis, light reaction Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis. got7fsn_ti biological_process owl:Class
GO:0072294 biolink:NamedThing specification of metanephric connecting tubule identity The process in which the connecting tubule of the metanephric nephron acquires its identity. got7fsn_ti mah 2010-04-09T04:00:31Z biological_process owl:Class
GO:0072293 biolink:NamedThing specification of metanephric nephron tubule identity The process in which the tubules arranged along the proximal/distal axis of the metanephric nephron acquire their identity. got7fsn_ti mah 2010-04-09T03:58:10Z biological_process owl:Class
GO:0048511 biolink:NamedThing rhythmic process Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. got7fsn_ti rhythm biological_process owl:Class
GO:0008150 biolink:NamedThing biological_process A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. got7fsn_ti physiological process|biological process|single organism process|single-organism process Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. jl 2012-09-19T15:05:24Z GO:0000004|GO:0044699|GO:0007582 Wikipedia:Biological_process biological_process owl:Class
GO:0062203 biolink:NamedThing Viteagnusin D synthase activity Catalysis of the reaction: H2O + peregrinol diphosphate = diphosphate + viteagnusin D. got7fsn_ti dph 2020-01-02T18:25:47Z RHEA:62180 molecular_function owl:Class
GO:0016838 biolink:NamedThing carbon-oxygen lyase activity, acting on phosphates Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate. got7fsn_ti EC:4.2.3.- molecular_function owl:Class
GO:0120152 biolink:NamedThing calcium-dependent outer dynein arm binding Binding to an outer dynein arm in the presence of calcium. got7fsn_ti krc 2018-04-27T16:33:39Z molecular_function owl:Class
GO:0048306 biolink:NamedThing calcium-dependent protein binding Binding to a protein or protein complex in the presence of calcium. got7fsn_ti molecular_function owl:Class
GO:0098039 biolink:NamedThing replicative transposition, DNA-mediated Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition. got7fsn_ti copy-and-paste transposition|transpositional DNA genome replication bm 2012-07-20T16:52:02Z biological_process owl:Class
GO:0006313 biolink:NamedThing transposition, DNA-mediated Any process involved in a type of transpositional recombination which occurs via a DNA intermediate. got7fsn_ti Class II transposition|Tc1/mariner transposition|Tc3 transposition|P-element transposition|P-element excision|DNA transposition GO:0006317|GO:0006318 biological_process owl:Class
GO:0048920 biolink:NamedThing posterior lateral line neuromast primordium migration The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. got7fsn_ti PLL neuromast primordium migration biological_process owl:Class
GO:0048883 biolink:NamedThing neuromast primordium migration The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop. got7fsn_ti lateral line primordium migration biological_process owl:Class
GO:0034070 biolink:NamedThing aminoglycoside 1-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring. got7fsn_ti molecular_function owl:Class
GO:0034069 biolink:NamedThing aminoglycoside N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + N-acetylaminoglycoside. got7fsn_ti kanamycin acetyltransferase activity molecular_function owl:Class
GO:0061663 biolink:NamedThing NEDD8 ligase activity Catalysis of the transfer of NEDD8 to a substrate protein via the reaction X-NEDD8 + S --> X + S-NEDD8, where X is either an E2 or E3 enzyme, the X-NEDD8 linkage is a thioester bond, and the S-NEDD8 linkage is an isopeptide bond between the C-terminal amino acid of NEDD8 and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T13:57:00Z molecular_function owl:Class
GO:0019788 biolink:NamedThing NEDD8 transferase activity Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. got7fsn_ti RUB1 conjugating enzyme activity|NEDD8 conjugating enzyme activity|Hub1 conjugating enzyme activity GO:0019945|GO:0042295|GO:0016976 Reactome:R-HSA-8956025|Reactome:R-HSA-8952618|Reactome:R-HSA-8951764|Reactome:R-HSA-8952638|Reactome:R-HSA-8951661|Reactome:R-HSA-8951648|Reactome:R-HSA-8952044 molecular_function owl:Class
GO:0106054 biolink:NamedThing tRNA U34 thiol-transferase activity Catalysis of the reaction: uridine34 in tRNA + a [TusE sulfur carrier protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 2-thiouridine34 in tRNA + a [TusE sulfur carrier protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+. got7fsn_ti tRNA-specific 2-thiouridylase|tRNA U34 2-thiouridylase hjd 2017-09-05T19:10:12Z molecular_function owl:Class
GO:0016783 biolink:NamedThing sulfurtransferase activity Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). got7fsn_ti sulphurtransferase activity|tRNA sulfurtransferase activity Reactome:R-HSA-6782264|EC:2.8.1.-|Reactome:R-HSA-1614618|Reactome:R-HSA-947538 molecular_function owl:Class
GO:0021852 biolink:NamedThing pyramidal neuron migration to cerebral cortex The migration of a pyramidal neuron precursor from the ventricular zone to the correct layer of the cerebral cortex. got7fsn_ti projection neuron migration|pyramidal neuron migration https://github.com/geneontology/go-ontology/issues/21476 biological_process owl:Class
GO:0001764 biolink:NamedThing neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. got7fsn_ti neuron guidance|neuron chemotaxis|neuronal migration Wikipedia:Neuron_migration|Wikipedia:Neural_development#Neuron_migration biological_process owl:Class
GO:0044651 biolink:NamedThing adhesion of symbiont to host epithelial cell The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly. got7fsn_ti jl 2012-07-12T12:47:09Z biological_process owl:Class
GO:0044650 biolink:NamedThing adhesion of symbiont to host cell The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly. got7fsn_ti jl 2012-07-12T12:42:14Z biological_process owl:Class
GO:0003026 biolink:NamedThing regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control. got7fsn_ti aortic arch baroreceptor control of systemic arterial blood pressure biological_process owl:Class
GO:0001976 biolink:NamedThing nervous system process involved in regulation of systemic arterial blood pressure The regulation of blood pressure mediated by detection of stimuli and a neurological response. got7fsn_ti blood pressure regulation by neurological process|neurological process involved in regulation of systemic arterial blood pressure|neurological system process involved in regulation of systemic arterial blood pressure|fast control of arterial pressure biological_process owl:Class
GO:0051504 biolink:NamedThing diterpene phytoalexin precursor biosynthetic process pathway A branched pathway that produces the precursors to four structurally distinct types of polycyclic diterpenes. The pathway starts with the cyclization of geranylgeranyl diphosphate into ent-copalyl diphosphate and syn-copalyl diphosphate. The catalytic conversion by diterpene cyclases of these two compounds produces the four diterpene hydrocarbons which are precursors to the four structurally distinct classes of diterpene phytoalexins. got7fsn_ti diterpene phytoalexin precursor synthesis pathway|diterpene phytoalexin precursor formation pathway|diterpene phytoalexin precursor anabolism pathway MetaCyc:PWY-2981 biological_process owl:Class
GO:0046246 biolink:NamedThing terpene biosynthetic process The chemical reactions and pathways resulting in the formation of terpenes, any of a large group of hydrocarbons made up of isoprene units. got7fsn_ti terpene biosynthesis|terpene synthesis|terpene formation|terpene anabolism biological_process owl:Class
GO:0018748 biolink:NamedThing iprodione amidohydrolase activity Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate. got7fsn_ti UM-BBD_reactionID:r0706 molecular_function owl:Class
GO:0098681 biolink:NamedThing synaptic ribbon A non-membrane bound, electron dense structure associated that extends perpendicular to the presynaptic membrane in ribbon synapses. The ribbon's surface is studded with small particles to which synaptic vesicles tether via fine filaments. The tethered vesicles function as a pool, several fold greater than the docked pool available for fast release, which supports sustained release of vesicles. Synaptic ribbons may be plate like or spherical. got7fsn_ti dos 2017-02-05T15:59:43Z cellular_component owl:Class
GO:0043232 biolink:NamedThing intracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. got7fsn_ti intracellular non-membrane-enclosed organelle cellular_component owl:Class
GO:0005585 biolink:NamedThing collagen type II trimer A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils. got7fsn_ti Wikipedia:Collagen_type_II cellular_component owl:Class
GO:0005583 biolink:NamedThing fibrillar collagen trimer Any triple helical collagen trimer that forms fibrils. got7fsn_ti cellular_component owl:Class
GO:0150017 biolink:NamedThing basal proximal dendrite Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is the closest to the cell body of the neuron (the soma). got7fsn_ti bc 2017-12-21T12:17:00Z cellular_component owl:Class
GO:0097441 biolink:NamedThing basal dendrite A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon. got7fsn_ti basilar dendrite pr 2012-12-06T13:46:28Z NIF_Subcellular:sao1079900774 cellular_component owl:Class
GO:0010461 biolink:NamedThing light-activated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a light stimulus. got7fsn_ti molecular_function owl:Class
GO:0005216 biolink:NamedThing ion channel activity Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). got7fsn_ti molecular_function owl:Class
GO:0034319 biolink:NamedThing alcohol O-butanoyltransferase activity Catalysis of the reaction: butanoyl-CoA + an alcohol = CoA + a butyl ester. got7fsn_ti molecular_function owl:Class
GO:0034318 biolink:NamedThing alcohol O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on an alcohol acceptor molecule. got7fsn_ti acyl-CoA:alcohol O-acyltransferase activity|acyl-CoA:ethanol O-acyltransferase|acyl-coenzymeA:alcohol O-acyltransferase activity|AEATase activity|alcohol acyltransferase activity|acyl-coenzymeA:ethanol O-acyltransferase activity molecular_function owl:Class
GO:0007310 biolink:NamedThing oocyte dorsal/ventral axis specification The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte dorsal/ventral axis determination|oocyte dorsal-ventral axis specification|oocyte dorsoventral axis specification GO:0008072|GO:0048123 biological_process owl:Class
GO:0007309 biolink:NamedThing oocyte axis specification The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte axis determination GO:0048111 biological_process owl:Class
GO:0050267 biolink:NamedThing rubber cis-polyprenylcistransferase activity Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit. got7fsn_ti rubber transferase activity|rubber allyltransferase activity|poly-cis-polyprenyl-diphosphate:isopentenyl-diphosphate polyprenylcistransferase activity|cis-prenyl transferase activity|isopentenyl pyrophosphate cis-1,4-polyisoprenyl transferase activity|rubber polymerase activity|rubber prenyltransferase activity RHEA:18801|EC:2.5.1.20|MetaCyc:2.5.1.20-RXN molecular_function owl:Class
GO:0002094 biolink:NamedThing polyprenyltransferase activity Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor). got7fsn_ti molecular_function owl:Class
GO:0035894 biolink:NamedThing positive regulation of platelet aggregation in other organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism. got7fsn_ti upregulation of platelet aggregation in other organism|up-regulation of platelet aggregation in other organism bf 2011-06-15T02:28:46Z biological_process owl:Class
GO:0035892 biolink:NamedThing modulation of platelet aggregation in other organism Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. got7fsn_ti regulation of platelet aggregation in other organism|modulation by organism of platelet aggregation in other organism bf 2011-06-15T02:21:10Z biological_process owl:Class
GO:0072010 biolink:NamedThing glomerular epithelium development The process whose specific outcome is the progression of the glomerular epithelium over time, from its formation to the mature structure. The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. got7fsn_ti mah 2010-01-25T02:02:14Z biological_process owl:Class
GO:0072073 biolink:NamedThing kidney epithelium development The process whose specific outcome is the progression of an epithelium in the kidney over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. got7fsn_ti mah 2010-01-25T04:37:42Z biological_process owl:Class
GO:0051524 biolink:NamedThing cell growth mode switching, bipolar to monopolar The process in which a cell switches from bipolar cell growth to monopolar cell growth. got7fsn_ti biological_process owl:Class
GO:0061162 biolink:NamedThing establishment of monopolar cell polarity The specification and formation of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. got7fsn_ti dph 2010-06-23T09:30:59Z biological_process owl:Class
GO:0018627 biolink:NamedThing 2-aminobenzenesulfonate 2,3-dioxygenase activity Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol. got7fsn_ti 2-aminobenzenesulfonate dioxygenase activity|2-aminosulfobenzene 2,3-dioxygenase activity|2-aminobenzenesulphonate 2,3-dioxygenase activity|2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)|2-aminobenzenesulphonate dioxygenase activity GO:0018605 KEGG_REACTION:R05156|EC:1.14.12.14|MetaCyc:2ASDOSALCAL-RXN|UM-BBD_reactionID:r0218|RHEA:23468 molecular_function owl:Class
GO:0016708 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor. got7fsn_ti oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor EC:1.14.12.- molecular_function owl:Class
GO:0120101 biolink:NamedThing bacterial-type flagellum stator complex A hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. The A and B proteins form a channel through which flow the ions that power the bacterial-type flagellum. They form the stator, or nonrotating portion, of the flagellum motor with the B protein apparently attached to the peptidoglycan cell wall. Examples include the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. got7fsn_ti bacterial-type flagellum torque generator complex|bacterial-type flagellum motor force generator complex krc 2017-10-03T16:06:16Z cellular_component owl:Class
GO:0005887 biolink:NamedThing integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to plasma membrane cellular_component owl:Class
GO:0019156 biolink:NamedThing isoamylase activity Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins. got7fsn_ti debranching enzyme activity|glycogen alpha-1,6-glucanohydrolase activity MetaCyc:RXN-12280|MetaCyc:3.2.1.68-RXN|EC:3.2.1.68|MetaCyc:RXN-14380 molecular_function owl:Class
GO:0004553 biolink:NamedThing hydrolase activity, hydrolyzing O-glycosyl compounds Catalysis of the hydrolysis of any O-glycosyl bond. got7fsn_ti O-glucosyl hydrolase activity GO:0016800 Reactome:R-HSA-9661820|EC:3.2.1.-|Reactome:R-HSA-6786652|Reactome:R-HSA-5694563 molecular_function owl:Class
GO:0110148 biolink:NamedThing biomineralization The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products. got7fsn_ti mineralization|biomineralisation|mineralisation|biomineral formation kmv 2019-06-10T17:55:28Z Wikipedia:Biomineralization biological_process owl:Class
GO:0050386 biolink:NamedThing ureidosuccinase activity Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+). got7fsn_ti N-carbamoyl-L-aspartate amidohydrolase activity MetaCyc:UREIDOSUCCINASE-RXN|EC:3.5.1.7|KEGG_REACTION:R00484|RHEA:14365 molecular_function owl:Class
GO:0018160 biolink:NamedThing peptidyl-pyrromethane cofactor linkage The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine. got7fsn_ti dipyrromethane cofactor binding|peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine GO:0033035|GO:0018354 RESID:AA0252 biological_process owl:Class
GO:0018198 biolink:NamedThing peptidyl-cysteine modification The modification of peptidyl-cysteine. got7fsn_ti biological_process owl:Class
GO:0090216 biolink:NamedThing positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Any process that increases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. got7fsn_ti tb 2010-01-12T10:00:45Z biological_process owl:Class
GO:0090218 biolink:NamedThing positive regulation of lipid kinase activity Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. got7fsn_ti tb 2010-01-12T10:18:30Z biological_process owl:Class
GO:0048658 biolink:NamedThing anther wall tapetum development The process whose specific outcome is the progression of the anther wall tapetum over time, from its formation to the mature structure. got7fsn_ti tapetum development|tapetal layer development biological_process owl:Class
GO:0048856 biolink:NamedThing anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti development of an anatomical structure biological_process owl:Class
GO:0042391 biolink:NamedThing regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti biological_process owl:Class
GO:0065008 biolink:NamedThing regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. got7fsn_ti regulation of biological attribute|regulation of biological characteristic biological_process owl:Class
GO:1990216 biolink:NamedThing positive regulation by symbiont of host transcription Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-10T15:45:17Z biological_process owl:Class
GO:0052026 biolink:NamedThing modulation by symbiont of host transcription Any process in which an organism modulates the frequency, rate or extent of its host's transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0022021 biolink:NamedThing caudal ganglionic eminence cell proliferation The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class
GO:0022012 biolink:NamedThing subpallium cell proliferation in forebrain The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class
GO:0021676 biolink:NamedThing rhombomere 8 structural organization The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 8 structural organisation biological_process owl:Class
GO:0021595 biolink:NamedThing rhombomere structural organization The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. got7fsn_ti rhombomere structural organisation biological_process owl:Class
GO:0042717 biolink:NamedThing plasma membrane-derived chromatophore membrane The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles. got7fsn_ti cellular_component owl:Class
GO:0034357 biolink:NamedThing photosynthetic membrane A membrane enriched in complexes formed of reaction centers, accessory pigments and electron carriers, in which photosynthetic reactions take place. got7fsn_ti cellular_component owl:Class
GO:0036177 biolink:NamedThing filamentous growth of a population of unicellular organisms in response to pH The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti bf 2012-03-29T01:43:04Z biological_process owl:Class
GO:0009268 biolink:NamedThing response to pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti biological_process owl:Class
GO:0010623 biolink:NamedThing programmed cell death involved in cell development The activation of endogenous cellular processes that result in the death of a cell as part of its development. got7fsn_ti programmed cell death involved in development|developmental programmed cell death This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. biological_process owl:Class
GO:0048869 biolink:NamedThing cellular developmental process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. got7fsn_ti biological_process owl:Class
GO:0110036 biolink:NamedThing C2 domain binding Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes. got7fsn_ti kmv 2017-07-20T20:45:56Z molecular_function owl:Class
GO:0019904 biolink:NamedThing protein domain specific binding Binding to a specific domain of a protein. got7fsn_ti protein domain-specific binding molecular_function owl:Class
GO:0047578 biolink:NamedThing 4-hydroxyglutamate transaminase activity Catalysis of the reaction: 4-hydroxy-L-glutamate + 2-oxoglutarate = 4-hydroxy-2-oxoglutarate + L-glutamate. got7fsn_ti 4-hydroxyglutamate aminotransferase activity|4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase activity MetaCyc:4-HYDROXYGLUTAMATE-AMINOTRANSFERASE-RXN|RHEA:10480|EC:2.6.1.23|Reactome:R-HSA-6784393 molecular_function owl:Class
GO:0008483 biolink:NamedThing transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. got7fsn_ti aminotransferase activity Reactome:R-HSA-1237102|EC:2.6.1.- molecular_function owl:Class
GO:0047906 biolink:NamedThing fucosterol-epoxide lyase activity Catalysis of the reaction: (24R,24'R)-fucosterol epoxide = acetaldehyde + desmosterol. got7fsn_ti (24R,24'R)-fucosterol-epoxide acetaldehyde-lyase activity|(24R,24'R)-fucosterol-epoxide acetaldehyde-lyase (desmosterol-forming) KEGG_REACTION:R03723|EC:4.1.2.33|MetaCyc:FUCOSTEROL-EPOXIDE-LYASE-RXN|RHEA:10884 molecular_function owl:Class
GO:0016832 biolink:NamedThing aldehyde-lyase activity Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. got7fsn_ti aldolase activity GO:0016228 EC:4.1.2.- molecular_function owl:Class
GO:0036496 biolink:NamedThing regulation of translational initiation by eIF2 alpha dephosphorylation Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha. got7fsn_ti bf 2015-02-05T10:21:31Z biological_process owl:Class
GO:0008152 biolink:NamedThing metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. got7fsn_ti metabolism|metabolic process resulting in cell growth|single-organism metabolic process|multicellular organism metabolic process|metabolism resulting in cell growth Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. jl 2012-10-17T15:46:40Z GO:0044236|GO:0044710 Wikipedia:Metabolism biological_process owl:Class
GO:0019081 biolink:NamedThing viral translation A process by which viral mRNA is translated into viral protein, using the host cellular machinery. got7fsn_ti viral protein formation|viral protein synthesis|viral protein biosynthesis|viral protein anabolism|viral protein biosynthetic process biological_process owl:Class
GO:0035041 biolink:NamedThing sperm chromatin decondensation Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus. got7fsn_ti biological_process owl:Class
GO:0006325 biolink:NamedThing chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. got7fsn_ti chromatin organisation|chromatin modification|establishment or maintenance of chromatin architecture GO:0016568 biological_process owl:Class
GO:0002299 biolink:NamedThing alpha-beta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti alpha-beta intraepithelial T-lymphocyte differentiation|alpha-beta intraepithelial T cell development|alpha-beta intraepithelial T-cell differentiation|alpha-beta intraepithelial T lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0046632 biolink:NamedThing alpha-beta T cell differentiation The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex. got7fsn_ti alpha-beta T-cell differentiation|alpha-beta T cell development|alpha-beta T lymphocyte differentiation|alpha-beta T-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:1900049 biolink:NamedThing regulation of histone exchange Any process that modulates the frequency, rate or extent of histone exchange. got7fsn_ti regulation of histone displacement|regulation of histone chaperone|regulation of histone replacement se 2012-01-19T10:59:02Z biological_process owl:Class
GO:1902275 biolink:NamedThing regulation of chromatin organization Any process that modulates the frequency, rate or extent of chromatin organization. got7fsn_ti regulation of chromatin modification|regulation of establishment or maintenance of chromatin architecture|regulation of chromatin organisation bf 2013-07-01T13:21:52Z GO:1903308 biological_process owl:Class
GO:0060087 biolink:NamedThing relaxation of vascular associated smooth muscle A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity. got7fsn_ti vascular smooth muscle relaxation|relaxation of vascular smooth muscle|positive regulation of relaxation of vascular smooth muscle|regulation of relaxation of vascular smooth muscle|negative regulation of relaxation of vascular smooth muscle GO:1905657|GO:1905658|GO:1905659 biological_process owl:Class
GO:0044557 biolink:NamedThing relaxation of smooth muscle A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. got7fsn_ti smooth muscle relaxation jl 2012-04-05T02:42:28Z biological_process owl:Class
GO:0043571 biolink:NamedThing maintenance of CRISPR repeat elements Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences. got7fsn_ti maintenance of clustered regularly interspaced short palindromic repeat elements|CRISPR element metabolic process|CRISPR element metabolism biological_process owl:Class
GO:0043570 biolink:NamedThing maintenance of DNA repeat elements Any process involved in sustaining the fidelity and copy number of DNA repeat elements. got7fsn_ti biological_process owl:Class
GO:0050985 biolink:NamedThing peptidyl-threonine sulfation The sulfation of peptidyl-threonine to form peptidyl-O-sulfo-L-threonine. got7fsn_ti RESID:AA0362 biological_process owl:Class
GO:0006477 biolink:NamedThing protein sulfation The addition of a sulfate group as an ester to a protein amino acid. got7fsn_ti protein amino acid sulfation|protein amino acid sulphation biological_process owl:Class
GO:1900602 biolink:NamedThing endocrocin biosynthetic process The chemical reactions and pathways resulting in the formation of endocrocin. got7fsn_ti endocrocin biosynthesis|endocrocin formation|endocrocin synthesis|endocrocin anabolism di 2012-05-15T06:57:42Z biological_process owl:Class
GO:0044550 biolink:NamedThing secondary metabolite biosynthetic process The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. got7fsn_ti secondary metabolite biosynthesis jl 2012-03-29T01:55:18Z biological_process owl:Class
GO:0034857 biolink:NamedThing 2-(methylthio)benzothiazole monooxygenase activity Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole. got7fsn_ti UM-BBD_reactionID:r1287 molecular_function owl:Class
GO:0016705 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. got7fsn_ti oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous EC:1.14.-.- molecular_function owl:Class
GO:0070420 biolink:NamedThing Ku-DNA ligase complex A nonhomologous end joining complex that contains one or more Ku monomers and one or more DNA ligase molecules from the LigC or LigD family, and mediates nonhomologous end joining in bacteria. got7fsn_ti cellular_component owl:Class
GO:0070419 biolink:NamedThing nonhomologous end joining complex A protein complex that plays a role in DNA double-strand break repair via nonhomologous end joining. Such complexes typically contain a specialized DNA ligase (e.g. Lig4 in eukaryotes) and one or more proteins that bind to DNA ends. got7fsn_ti non-homologous end joining complex|NHEJ complex cellular_component owl:Class
GO:0052805 biolink:NamedThing imidazole-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. got7fsn_ti imidazole catabolism|imidazole degradation|imidazole breakdown biological_process owl:Class
GO:0044270 biolink:NamedThing cellular nitrogen compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds. got7fsn_ti nitrogen compound catabolism|nitrogen compound breakdown|nitrogen compound degradation biological_process owl:Class
GO:0031035 biolink:NamedThing myosin filament disassembly The disassembly of a filament composed of myosin molecules. got7fsn_ti myosin depolymerization biological_process owl:Class
GO:0031033 biolink:NamedThing myosin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules. got7fsn_ti myosin polymerization or depolymerization|myosin filament assembly or disassembly|myosin filament organisation Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton. biological_process owl:Class
GO:0011000 biolink:NamedThing replication fork arrest at mating type locus A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus. got7fsn_ti tb 2009-06-24T12:02:48Z biological_process owl:Class
GO:0043111 biolink:NamedThing replication fork arrest Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork. Replication fork arrest is one of the 'quality control' processes ensuring that DNA-dependent DNA replication occurs correctly. DNA replication fork arrest during DNA-dependent DNA replication is not known to occur outside of cases where a replication error needs to be prevented or corrected. got7fsn_ti replication fork stalling|negative regulation of DNA replication at replication fork barrier|replication fork blocking See also the biological process term 'site-specific replication termination ; GO:0071170' and its children. biological_process owl:Class
GO:0019365 biolink:NamedThing pyridine nucleotide salvage Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis. got7fsn_ti pyridine nucleotide cycling biological_process owl:Class
GO:0043173 biolink:NamedThing nucleotide salvage Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis. got7fsn_ti Wikipedia:Nucleotide_salvage biological_process owl:Class
GO:0099646 biolink:NamedThing neurotransmitter receptor transport, plasma membrane to endosome Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome. got7fsn_ti biological_process owl:Class
GO:0048227 biolink:NamedThing plasma membrane to endosome transport Transport of a vesicle from the plasma membrane to the endosome. got7fsn_ti biological_process owl:Class
GO:1990736 biolink:NamedThing regulation of vascular associated smooth muscle cell membrane depolarization Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell. got7fsn_ti regulation of vascular smooth muscle cell membrane depolarization sl 2015-04-29T22:33:19Z biological_process owl:Class
GO:0051899 biolink:NamedThing membrane depolarization The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti biological_process owl:Class
GO:0018452 biolink:NamedThing 5-exo-hydroxycamphor dehydrogenase activity Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane. got7fsn_ti RHEA:32879|EC:1.1.1.327|MetaCyc:R542-RXN|UM-BBD_reactionID:r0427 molecular_function owl:Class
GO:0016616 biolink:NamedThing oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. got7fsn_ti glycolate reductase|NADH-dependent glyoxylate reductase|glyoxylic acid reductase Reactome:R-HSA-975629|EC:1.1.1.- molecular_function owl:Class
GO:0009947 biolink:NamedThing centrolateral axis specification The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf. got7fsn_ti mediolateral axis specification|centrolateral axis determination biological_process owl:Class
GO:0009798 biolink:NamedThing axis specification The establishment, maintenance and elaboration of a pattern along a line or around a point. got7fsn_ti axis determination biological_process owl:Class
GO:0018555 biolink:NamedThing phenanthrene dioxygenase activity Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0455 molecular_function owl:Class
GO:0016702 biolink:NamedThing oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. got7fsn_ti Reactome:R-HSA-5164399|Reactome:R-HSA-9018880|Reactome:R-HSA-9020274|Reactome:R-HSA-9026408|EC:1.13.11.-|Reactome:R-HSA-2161907|Reactome:R-HSA-2161775|Reactome:R-HSA-2161917|Reactome:R-HSA-9026918 molecular_function owl:Class
GO:0005172 biolink:NamedThing vascular endothelial growth factor receptor binding Binding to a vascular endothelial growth factor receptor. got7fsn_ti VEGF receptor binding|vascular endothelial growth factor|vascular endothelial growth factor receptor ligand|VEGFR binding molecular_function owl:Class
GO:0070851 biolink:NamedThing growth factor receptor binding Binding to a growth factor receptor. got7fsn_ti mah 2009-08-07T11:23:02Z molecular_function owl:Class
GO:0140113 biolink:NamedThing extracellular microvesicle biogenesis The assembly and secretion of a set of components to form an extracellular microvesicule, a membrane-bounded vesicle that ranges in size 100 nm to 1 micron in size) and exits the cell by budding. got7fsn_ti extracellular microvesicle assembly https://github.com/geneontology/go-ontology/issues/14256 pg 2017-10-23T12:00:11Z biological_process owl:Class
GO:0140112 biolink:NamedThing extracellular vesicle biogenesis The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content. got7fsn_ti extracellular vesicle assembly https://github.com/geneontology/go-ontology/issues/14256 pg 2017-10-23T11:53:42Z biological_process owl:Class
GO:0031250 biolink:NamedThing anaerobic ribonucleoside-triphosphate reductase complex An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit. got7fsn_ti cellular_component owl:Class
GO:0032991 biolink:NamedThing protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. got7fsn_ti protein-protein complex|macromolecular complex|protein complex|protein containing complex|macromolecule complex A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. GO:0043234 cellular_component owl:Class
GO:0046294 biolink:NamedThing formaldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. got7fsn_ti formaldehyde degradation|formaldehyde breakdown|methanal catabolic process|formaldehyde catabolism|methanal catabolism biological_process owl:Class
GO:0044282 biolink:NamedThing small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. got7fsn_ti small molecule catabolism Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. jl 2010-01-26T12:06:10Z biological_process owl:Class
GO:0071133 biolink:NamedThing alpha9-beta1 integrin-ADAM8 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM8. got7fsn_ti ITGA9-ITGB1-ADAM8 complex mah 2009-11-13T02:28:49Z cellular_component owl:Class
GO:0007636 biolink:NamedThing chemosensory jump behavior The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance. got7fsn_ti jump response to chemical stimulus|chemosensory jump behaviour biological_process owl:Class
GO:0007635 biolink:NamedThing chemosensory behavior Behavior that is dependent upon the sensation of chemicals. got7fsn_ti chemosensory behaviour|behavioural response to chemical stimulus|behavioral response to chemical stimulus biological_process owl:Class
GO:0060592 biolink:NamedThing mammary gland formation The process pertaining to the initial formation of the mammary gland from unspecified parts. The process begins with formation of the mammary line and ends when the solid mammary bud invades the primary mammary mesenchyme. got7fsn_ti mammary line formation|mammary placode formation|mammary sprout formation|mammary bud formation dph 2009-05-13T08:47:52Z biological_process owl:Class
GO:0035740 biolink:NamedThing CD8-positive, alpha-beta T cell proliferation The expansion of a CD8-positive, alpha-beta T cell population by cell division. got7fsn_ti bf 2011-03-17T02:13:54Z biological_process owl:Class
GO:0036037 biolink:NamedThing CD8-positive, alpha-beta T cell activation The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti bf 2011-11-03T10:34:12Z biological_process owl:Class
GO:0097674 biolink:NamedThing SCF-YLR352W ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is YLR352W in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:30:54Z cellular_component owl:Class
GO:0019005 biolink:NamedThing SCF ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). got7fsn_ti CDL1 complex|cullin-RING ligase 1|SCF complex|CRL1 complex|SCF complex substrate recognition subunit|Cul1-RING ubiquitin ligase complex|Skp1/Cul1/F-box protein complex Wikipedia:SCF_complex cellular_component owl:Class
GO:0030532 biolink:NamedThing small nuclear ribonucleoprotein complex A ribonucleoprotein complex that contains at least one RNA of the small nuclear RNA (snRNA) class and as well as its associated proteins. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP, U4/U6 snRNP, or 7SK snRNP. Many, of these complexes become part of the spliceosome involved in splicing of nuclear mRNAs. Others are involved in regulation of transcription elongation or 3'-end processing of replication-dependent histone pre-mRNAs. got7fsn_ti small nuclear ribonucleoprotein|snRNP Wikipedia:SnRNP cellular_component owl:Class
GO:0140513 biolink:NamedThing nuclear protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. got7fsn_ti nuclear complex pg 2020-09-09T05:12:38Z cellular_component owl:Class
GO:0034039 biolink:NamedThing 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity Catalysis of the removal of 8-oxo-7,8-dihydroguanine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. got7fsn_ti 8-oxoG DNA N-glycosylase activity molecular_function owl:Class
GO:0008534 biolink:NamedThing oxidized purine nucleobase lesion DNA N-glycosylase activity Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. got7fsn_ti DNA glycosylase/AP-lyase activity|DNA glycosylase/beta-lyase activity|oxidized purine base lesion DNA N-glycosylase activity|8-oxoguanine DNA glycosylase activity|2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity|formamidopyrimidine-DNA glycosylase activity|Fapy-DNA glycosylase activity|2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity|DNA-formamidopyrimidine glycosylase activity|purine-specific oxidized base lesion DNA N-glycosylase activity|bifunctional DNA glycosylase activity|Fpg protein|deoxyribonucleate glycosidase activity|DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing] Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. GO:0003907 Reactome:R-HSA-110244|MetaCyc:3.2.2.23-RXN|Reactome:R-HSA-110229|Reactome:R-HSA-110243|EC:3.2.2.23 molecular_function owl:Class
GO:0044186 biolink:NamedThing host cell lipid droplet Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins. got7fsn_ti host cell lipid particle|host cell lipid adiposome|host cell lipid body jl 2009-10-15T03:05:06Z cellular_component owl:Class
GO:0033655 biolink:NamedThing host cell cytoplasm part Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cytoplasm component Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class
GO:0010723 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to iron Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. got7fsn_ti biological_process owl:Class
GO:0034395 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to iron Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an iron stimulus. got7fsn_ti regulation of specific transcription from RNA polymerase II promoter in response to iron biological_process owl:Class
GO:0090532 biolink:NamedThing L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate. got7fsn_ti L-ascorbic acid biosynthesis via UDP-alpha-D-glucuronate This pathway occurs in most vertebrates, although not in guinea pigs and primates, including humans. tb 2013-02-06T15:31:01Z biological_process owl:Class
GO:0019853 biolink:NamedThing L-ascorbic acid biosynthetic process The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. got7fsn_ti L-ascorbic acid formation|vitamin C biosynthesis|L-ascorbic acid anabolism|ascorbate biosynthesis|L-ascorbic acid biosynthesis|ascorbate biosynthetic process|vitamin C biosynthetic process|L-ascorbic acid synthesis MetaCyc:PWY-882 biological_process owl:Class
GO:0009404 biolink:NamedThing toxin metabolic process The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. got7fsn_ti toxin metabolism biological_process owl:Class
GO:0019748 biolink:NamedThing secondary metabolic process The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. got7fsn_ti secondary metabolite metabolic process|secondary metabolite metabolism|secondary metabolism Wikipedia:Secondary_metabolism biological_process owl:Class
GO:0043891 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+. got7fsn_ti triosephosphate dehydrogenase (NAD(P))|glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)|triosephosphate dehydrogenase (NAD(P)+)|NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity|D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating) MetaCyc:GAPDHSYNEC-RXN|EC:1.2.1.59 molecular_function owl:Class
GO:0016620 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti Reactome:R-HSA-1222583|EC:1.2.1.- molecular_function owl:Class
GO:0045457 biolink:NamedThing ecdysteroid secretion The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. got7fsn_ti biological_process owl:Class
GO:0035929 biolink:NamedThing steroid hormone secretion The regulated release of any steroid that acts as a hormone into the circulatory system. got7fsn_ti bf 2011-07-20T01:01:00Z biological_process owl:Class
GO:0019151 biolink:NamedThing galactose 1-dehydrogenase activity Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+. got7fsn_ti beta-galactose dehydrogenase activity|D-galactose 1-dehydrogenase activity|NAD-dependent D-galactose dehydrogenase activity|D-galactose:NAD+ 1-oxidoreductase activity|D-galactose dehydrogenase activity RHEA:21296|MetaCyc:GALACTODEHYDROG-RXN|EC:1.1.1.48 molecular_function owl:Class
GO:0033720 biolink:NamedThing (S)-mandelate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxy-2-phenylacetate + acceptor = 2-oxo-2-phenylacetate + reduced acceptor. got7fsn_ti MDH|(S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase activity|L(+)-mandelate dehydrogenase activity MetaCyc:MANDELATE-DEHYDROGENASE-RXN|RHEA:15749|UM-BBD_reactionID:r1048|MetaCyc:MANDELATE-OXY-RXN|EC:1.1.99.31 molecular_function owl:Class
GO:0016614 biolink:NamedThing oxidoreductase activity, acting on CH-OH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the CH-OH group of donors, other acceptors EC:1.1.-.-|Reactome:R-HSA-1500781 molecular_function owl:Class
GO:0002182 biolink:NamedThing cytoplasmic translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm. got7fsn_ti hjd 2011-06-09T03:14:42Z biological_process owl:Class
GO:0006414 biolink:NamedThing translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. got7fsn_ti translation elongation|protein synthesis elongation GO:0006442|GO:0006455 biological_process owl:Class
GO:0150015 biolink:NamedThing apical proximal dendrite The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma). got7fsn_ti bc 2017-12-21T12:09:26Z cellular_component owl:Class
GO:1990635 biolink:NamedThing proximal dendrite The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma). got7fsn_ti sl 2015-02-10T22:57:16Z cellular_component owl:Class
GO:0003904 biolink:NamedThing deoxyribodipyrimidine photo-lyase activity Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. got7fsn_ti CPD photolyase activity|phr A photolyase activity|deoxyribonucleic cyclobutane dipyrimidine photolyase activity|PhrB photolyase activity|deoxyribocyclobutadipyrimidine pyrimidine-lyase activity|PRE|photoreactivating enzyme activity|deoxyribonucleic photolyase activity|dipyrimidine photolyase (photosensitive)|photolyase activity|deoxyribodipyrimidine photolyase activity|DNA-photoreactivating enzyme|DNA cyclobutane dipyrimidine photolyase activity|deoxyribonucleate pyrimidine dimer lyase (photosensitive) MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN|RHEA:10672|EC:4.1.99.3 molecular_function owl:Class
GO:0003913 biolink:NamedThing DNA photolyase activity Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. got7fsn_ti MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN molecular_function owl:Class
GO:0046992 biolink:NamedThing oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y. got7fsn_ti oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors EC:1.21.-.- molecular_function owl:Class
GO:0016491 biolink:NamedThing oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. got7fsn_ti oxidoreductase activity, acting on other substrates|redox activity Reactome:R-HSA-209960|Reactome:R-HSA-9024624|Reactome:R-HSA-8878581|Reactome:R-HSA-9027033|Reactome:R-HSA-3095889|Reactome:R-HSA-9020260|Reactome:R-HSA-9024630|Reactome:R-HSA-9020249|EC:1.-.-.-|Reactome:R-HSA-5662660|Reactome:R-HSA-8936442|Reactome:R-HSA-9026917|Reactome:R-HSA-209921|Reactome:R-HSA-1614362|Reactome:R-HSA-9693722|Reactome:R-HSA-390425|Reactome:R-HSA-9025007|Reactome:R-HSA-390438|Reactome:R-HSA-9026001 molecular_function owl:Class
GO:0030169 biolink:NamedThing low-density lipoprotein particle binding Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. got7fsn_ti LDL binding molecular_function owl:Class
GO:0071813 biolink:NamedThing lipoprotein particle binding Binding to a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. got7fsn_ti plasma lipoprotein particle binding|lipoprotein binding|plasma lipoprotein binding mah 2010-09-06T03:16:01Z molecular_function owl:Class
GO:0071320 biolink:NamedThing cellular response to cAMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. got7fsn_ti cellular response to cyclic AMP|cellular response to adenosine 3',5'-cyclophosphate|cellular response to 3',5' cAMP|cellular response to 3',5'-cAMP mah 2009-12-10T05:12:15Z biological_process owl:Class
GO:0051591 biolink:NamedThing response to cAMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus. got7fsn_ti response to 3',5' cAMP|response to adenosine 3',5'-cyclophosphate|response to cyclic AMP|response to 3',5'-cAMP biological_process owl:Class
GO:0003233 biolink:NamedThing bulbus arteriosus morphogenesis The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber. got7fsn_ti dph 2009-10-13T11:07:30Z biological_process owl:Class
GO:0003206 biolink:NamedThing cardiac chamber morphogenesis The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart. got7fsn_ti heart chamber morphogenesis dph 2009-10-13T09:14:51Z biological_process owl:Class
GO:0006314 biolink:NamedThing intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. got7fsn_ti biological_process owl:Class
GO:0006310 biolink:NamedThing DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. got7fsn_ti biological_process owl:Class
GO:0071364 biolink:NamedThing cellular response to epidermal growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. got7fsn_ti cellular response to EGF stimulus mah 2009-12-11T03:05:34Z biological_process owl:Class
GO:0070849 biolink:NamedThing response to epidermal growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus. got7fsn_ti response to epidermal growth factor stimulus|response to EGF stimulus mah 2009-08-04T04:26:26Z biological_process owl:Class
GO:0098579 biolink:NamedThing active sex chromosome A sex chromosome that has not been inactivated. got7fsn_ti cellular_component owl:Class
GO:0000803 biolink:NamedThing sex chromosome A chromosome involved in sex determination. got7fsn_ti cellular_component owl:Class
GO:0106283 biolink:NamedThing ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity Catalysis of the reaction: NAD(+) + ursodeoxycholate = 7-oxolithocholate + H(+) + NADH. got7fsn_ti hjd 2020-07-29T17:52:44Z RHEA:42028 molecular_function owl:Class
GO:0033764 biolink:NamedThing steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. got7fsn_ti molecular_function owl:Class
GO:0097051 biolink:NamedThing establishment of protein localization to endoplasmic reticulum membrane The directed movement of a protein to a specific location in the endoplasmic reticulum membrane. got7fsn_ti establishment of protein localisation in endoplasmic reticulum membrane|establishment of protein localization in endoplasmic reticulum membrane pr 2011-05-04T05:55:26Z biological_process owl:Class
GO:0090150 biolink:NamedThing establishment of protein localization to membrane The directed movement of a protein to a specific location in a membrane. got7fsn_ti establishment of protein localization in membrane|establishment of protein localisation in membrane tb 2009-12-08T03:18:51Z biological_process owl:Class
GO:0008710 biolink:NamedThing 8-amino-7-oxononanoate synthase activity Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA. got7fsn_ti 7-keto-8-aminopelargonic synthetase activity|7-keto-8-aminopelargonic acid synthetase activity|7-keto-8-amino-pelargonic acid synthetase activity|6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)|8-amino-7-ketopelargonate synthase activity|7-KAP synthetase activity|AONS activity|8-amino-7-oxopelargonate synthase activity KEGG_REACTION:R03210|RHEA:20712|MetaCyc:7KAPSYN-RXN|EC:2.3.1.47 molecular_function owl:Class
GO:0016747 biolink:NamedThing acyltransferase activity, transferring groups other than amino-acyl groups Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring acyl groups other than amino-acyl groups|transferase activity, transferring groups other than amino-acyl groups https://github.com/geneontology/go-ontology/issues/20486 EC:2.3.1.- molecular_function owl:Class
GO:0046838 biolink:NamedThing phosphorylated carbohydrate dephosphorylation The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it. got7fsn_ti biological_process owl:Class
GO:0044262 biolink:NamedThing cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. got7fsn_ti cellular carbohydrate metabolism|main pathways of carbohydrate metabolic process|main pathways of carbohydrate metabolism GO:0006092 biological_process owl:Class
GO:0031990 biolink:NamedThing mRNA export from nucleus in response to heat stress The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export. got7fsn_ti mRNA export from nucleus during heat stress|mRNA export from cell nucleus during heat stress biological_process owl:Class
GO:0034605 biolink:NamedThing cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. got7fsn_ti cellular response to heat stress biological_process owl:Class
GO:0060562 biolink:NamedThing epithelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. got7fsn_ti dph 2009-04-28T09:33:36Z biological_process owl:Class
GO:0035239 biolink:NamedThing tube morphogenesis The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. got7fsn_ti biological_process owl:Class
GO:0007072 biolink:NamedThing positive regulation of transcription involved in exit from mitosis Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. got7fsn_ti activation of transcription on exit from mitosis biological_process owl:Class
GO:0022402 biolink:NamedThing cell cycle process The cellular process that ensures successive accurate and complete genome replication and chromosome segregation. got7fsn_ti biological_process owl:Class
GO:0075209 biolink:NamedThing induction by symbiont of host cAMP-mediated signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host cAMP-mediated signaling|positive regulation by symbiont of host cAMP-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075206". biological_process owl:Class
GO:0075208 biolink:NamedThing modulation by symbiont of host cAMP-mediated signal transduction Any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host cAMP-mediated signaling Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont cAMP-mediated signal transduction ; GO:0075205". biological_process owl:Class
GO:0102648 biolink:NamedThing D-ribose 5-phosphate:D-fructose 6-phosphate transaldolase activity Catalysis of the reaction: D-fructose 6-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-glyceraldehyde 3-phosphate. got7fsn_ti MetaCyc:RXN-15790 molecular_function owl:Class
GO:0016744 biolink:NamedThing transketolase or transaldolase activity Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring aldehyde or ketonic groups https://github.com/geneontology/go-ontology/issues/20486 GO:0016745 EC:2.2.1.- molecular_function owl:Class
GO:0044630 biolink:NamedThing modulation of complement activation, lectin pathway in other organism A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism. got7fsn_ti regulation of complement activation, lectin pathway in other organism jl 2012-07-05T01:10:31Z biological_process owl:Class
GO:0001868 biolink:NamedThing regulation of complement activation, lectin pathway Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation. got7fsn_ti regulation of complement cascade, lectin pathway biological_process owl:Class
GO:0001626 biolink:NamedThing nociceptin receptor activity Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti OFQ receptor activity|nociceptin/orphanin-FQ receptor activity|orphanin-FQ receptor activity|ORPH receptor|X-opioid receptor activity molecular_function owl:Class
GO:0004985 biolink:NamedThing G protein-coupled opioid receptor activity Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti opioid receptor activity https://github.com/geneontology/go-ontology/issues/21110 molecular_function owl:Class
GO:0030655 biolink:NamedThing beta-lactam antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. got7fsn_ti beta-lactam antibiotic catabolism|beta-lactam antibiotic degradation|beta-lactam antibiotic breakdown biological_process owl:Class
GO:0072340 biolink:NamedThing cellular lactam catabolic process The chemical reactions and pathways resulting in the breakdown of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. got7fsn_ti cellular lactam breakdown|cellular lactam degradation|cellular lactam catabolism mah 2010-11-04T04:33:22Z biological_process owl:Class
GO:0007269 biolink:NamedThing neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. got7fsn_ti neurotransmitter release|neurotransmitter secretory pathway A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. GO:0010554 biological_process owl:Class
GO:0023061 biolink:NamedThing signal release The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. got7fsn_ti signal secretion 2010-02-16T09:30:50Z biological_process owl:Class
GO:0046377 biolink:NamedThing colanic acid metabolic process The chemical reactions and pathways involving colanic acid, a capsular bacterial polysaccharide composed of glucose, galactose, fucose and glucuronic acid residues. got7fsn_ti colanic acid metabolism biological_process owl:Class
GO:0044264 biolink:NamedThing cellular polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells. got7fsn_ti cellular glycan metabolic process|cellular glycan metabolism|cellular polysaccharide metabolism biological_process owl:Class
GO:0007158 biolink:NamedThing neuron cell-cell adhesion The attachment of a neuron to another cell via adhesion molecules. got7fsn_ti neuron adhesion|neuronal cell adhesion biological_process owl:Class
GO:0098609 biolink:NamedThing cell-cell adhesion The attachment of one cell to another cell via adhesion molecules. got7fsn_ti single organismal cell-cell adhesion dos 2014-04-16T13:40:03Z GO:0016337 biological_process owl:Class
GO:0001894 biolink:NamedThing tissue homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function. got7fsn_ti tissue maintenance biological_process owl:Class
GO:0060249 biolink:NamedThing anatomical structure homeostasis A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti anatomical structure maintenance biological_process owl:Class
GO:0018220 biolink:NamedThing peptidyl-threonine palmitoylation The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine. got7fsn_ti peptidyl-threonine O-palmitoylation Palmitoylation of a non-terminal threonine residue always occurs on an oxygen (O) atom. RESID:AA0079 biological_process owl:Class
GO:0018210 biolink:NamedThing peptidyl-threonine modification The modification of peptidyl-threonine. got7fsn_ti biological_process owl:Class
GO:0098920 biolink:NamedThing retrograde trans-synaptic signaling by lipid Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. got7fsn_ti biological_process owl:Class
GO:0099537 biolink:NamedThing trans-synaptic signaling Cell-cell signaling in either direction across the synaptic cleft. got7fsn_ti biological_process owl:Class
GO:0021589 biolink:NamedThing cerebellum structural organization The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. got7fsn_ti cerebellum structural organisation biological_process owl:Class
GO:0048532 biolink:NamedThing anatomical structure arrangement The process that gives rise to the configuration of the constituent parts of an anatomical structure. This process pertains to the physical shaping of a rudimentary structure. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti structural organization|anatomical structure structural organization|anatomical structure organization|organization of an anatomical structure biological_process owl:Class
GO:0097230 biolink:NamedThing cell motility in response to potassium ion Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus. got7fsn_ti potassium ion facilitation of cell motility|K+ facilitation of cell motility pr 2012-01-25T04:39:45Z biological_process owl:Class
GO:0048870 biolink:NamedThing cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. got7fsn_ti movement of a cell|cell locomotion|cell movement biological_process owl:Class
GO:0015195 biolink:NamedThing L-threonine transmembrane transporter activity Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid. got7fsn_ti threonine/serine:sodium symporter activity|L-threonine permease activity|L-threonine transporter activity GO:0015512 molecular_function owl:Class
GO:0015175 biolink:NamedThing neutral amino acid transmembrane transporter activity Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. got7fsn_ti neutral amino acid transporter activity molecular_function owl:Class
GO:0009041 biolink:NamedThing uridylate kinase activity Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. got7fsn_ti EC:2.7.4.22 molecular_function owl:Class
GO:0016776 biolink:NamedThing phosphotransferase activity, phosphate group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). got7fsn_ti EC:2.7.4.- molecular_function owl:Class
GO:0006869 biolink:NamedThing lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. got7fsn_ti biological_process owl:Class
GO:0030724 biolink:NamedThing testicular fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome. got7fsn_ti testicular fusome organisation|testicular fusome organization and biogenesis biological_process owl:Class
GO:0045478 biolink:NamedThing fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells. got7fsn_ti fusome organisation|fusome organization and biogenesis biological_process owl:Class
GO:0032298 biolink:NamedThing positive regulation of DNA-dependent DNA replication initiation Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication. got7fsn_ti stimulation of DNA replication initiation|up-regulation of DNA replication initiation|negative regulation of DNA replication initiation|upregulation of DNA replication initiation|up regulation of DNA replication initiation|activation of DNA replication initiation biological_process owl:Class
GO:0045740 biolink:NamedThing positive regulation of DNA replication Any process that activates or increases the frequency, rate or extent of DNA replication. got7fsn_ti stimulation of DNA replication|upregulation of DNA replication|up regulation of DNA replication|up-regulation of DNA replication|activation of DNA replication biological_process owl:Class
GO:0099135 biolink:NamedThing chimeric colonial development Development a structure consisting of multiple co-operating unicellular organisms of the same species, involving cells of more that one genotype. got7fsn_ti biological_process owl:Class
GO:0099120 biolink:NamedThing socially cooperative development The process whose specific outcome is the progression of a non-reproductive fruiting body over time, from its formation to the mature structure. A non-reproductive fruiting body is a colonial multicellular structure consisting of co-operating unicellular organisms, some of which are spores. An example of such a process is found in Dictyostelium discoideum and Myxococcus xanthus colonies. got7fsn_ti socially co-operative development|non-reproductive fruiting body development|colonial development https://github.com/geneontology/go-ontology/issues/20428 GO:0090702 biological_process owl:Class
GO:0044277 biolink:NamedThing cell wall disassembly A process that results in the breakdown of the cell wall. got7fsn_ti cellular cell wall disassembly jl 2010-01-14T02:00:34Z GO:0060871 biological_process owl:Class
GO:0071555 biolink:NamedThing cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. got7fsn_ti cellular cell wall organisation|cell wall organisation in other organism|cell wall organization at cellular level|cell wall organisation|cell wall organization and biogenesis|cellular cell wall organization|cell wall organization in other organism mah 2010-01-13T03:33:07Z GO:0044234|GO:0007047 biological_process owl:Class
GO:0033880 biolink:NamedThing phenylacetyl-CoA hydrolase activity Catalysis of the reaction: H(2)O + phenylglyoxylyl-CoA = CoA + H(+) + phenylglyoxylate. got7fsn_ti phenylglyoxylyl-CoA hydrolase activity MetaCyc:3.1.2.25-RXN|RHEA:15337|EC:3.1.2.25|KEGG_REACTION:R07294 molecular_function owl:Class
GO:0016289 biolink:NamedThing CoA hydrolase activity Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. got7fsn_ti Reactome:R-HSA-193385 molecular_function owl:Class
GO:0006259 biolink:NamedThing DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. got7fsn_ti DNA metabolism|cellular DNA metabolism GO:0055132 biological_process owl:Class
GO:0044260 biolink:NamedThing cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. got7fsn_ti cellular macromolecule metabolism|cellular biopolymer metabolic process GO:0034960 biological_process owl:Class
GO:0034210 biolink:NamedThing sterol deacetylation The removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti biological_process owl:Class
GO:0034208 biolink:NamedThing steroid deacetylation The removal of an acetyl group from a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti biological_process owl:Class
GO:0030866 biolink:NamedThing cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. got7fsn_ti cortical actin cytoskeleton stabilization|actin cortex stabilization|cortical resistance|cortical actin cytoskeleton organisation|cortical actin cytoskeleton organization and biogenesis GO:0033109 biological_process owl:Class
GO:0030036 biolink:NamedThing actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. got7fsn_ti actin cytoskeleton organization and biogenesis|actin cytoskeleton organisation|actin modulating activity biological_process owl:Class
GO:0036185 biolink:NamedThing 13-lipoxin reductase activity Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+. got7fsn_ti bf 2012-04-16T02:28:19Z Reactome:R-HSA-2161844 molecular_function owl:Class
GO:0035597 biolink:NamedThing N6-isopentenyladenosine methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A). got7fsn_ti i6A methylthiotransferase activity bf 2010-11-12T01:26:58Z molecular_function owl:Class
GO:0035596 biolink:NamedThing methylthiotransferase activity Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor. got7fsn_ti MTTase bf 2010-11-12T01:24:38Z molecular_function owl:Class
GO:0042085 biolink:NamedThing 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate. got7fsn_ti molecular_function owl:Class
GO:0008168 biolink:NamedThing methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule. got7fsn_ti methylase GO:0004480 Reactome:R-HSA-379387|Reactome:R-HSA-379464|Reactome:R-HSA-71286|EC:2.1.1.-|Reactome:R-HSA-6800149|Reactome:R-HSA-212269 molecular_function owl:Class
GO:0032103 biolink:NamedThing positive regulation of response to external stimulus Any process that activates, maintains or increases the rate of a response to an external stimulus. got7fsn_ti stimulation of response to external stimulus|up regulation of response to external stimulus|activation of response to external stimulus|up-regulation of response to external stimulus|upregulation of response to external stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0032101 biolink:NamedThing regulation of response to external stimulus Any process that modulates the frequency, rate or extent of a response to an external stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0035127 biolink:NamedThing post-embryonic limb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. got7fsn_ti biological_process owl:Class
GO:0035108 biolink:NamedThing limb morphogenesis The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping. got7fsn_ti limb bud morphogenesis biological_process owl:Class
GO:0071175 biolink:NamedThing MAML2-RBP-Jkappa-ICN1 complex A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML2-RBP-Jkappa-Notch1 complex mah 2009-11-23T02:36:28Z cellular_component owl:Class
GO:0006602 biolink:NamedThing creatinine catabolic process The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. got7fsn_ti creatinine degradation|creatinine catabolism|creatinine breakdown biological_process owl:Class
GO:0009974 biolink:NamedThing zeinoxanthin epsilon hydroxylase activity Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene. got7fsn_ti MetaCyc:RXN-5962|RHEA:57352|EC:1.14.14.158 molecular_function owl:Class
GO:0072374 biolink:NamedThing carotene epsilon hydroxylase activity Catalysis of the reaction: a carotene + NADPH + O2 + H+ = a beta-ring hydroxylcarotene + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene. got7fsn_ti mah 2010-11-19T03:57:55Z molecular_function owl:Class
GO:0035526 biolink:NamedThing retrograde transport, plasma membrane to Golgi The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles. got7fsn_ti bf 2010-05-05T10:52:49Z biological_process owl:Class
GO:0016192 biolink:NamedThing vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. got7fsn_ti vesicular transport|vesicle trafficking|vesicle transport|protein sorting along secretory pathway|nonselective vesicle transport GO:0006899 biological_process owl:Class
GO:0106301 biolink:NamedThing arachidonic acid 5,6-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-5,6-epoxyeicosatrienoic acid. got7fsn_ti hjd 2020-08-28T19:08:45Z RHEA:49936 molecular_function owl:Class
GO:0008392 biolink:NamedThing arachidonic acid epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. got7fsn_ti cytochrome P450 CYP2J5|cytochrome P450 CYP2J6 Reactome:R-HSA-211983 molecular_function owl:Class
GO:0033371 biolink:NamedThing T cell secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. got7fsn_ti T lymphocyte secretory granule organization|T-lymphocyte secretory granule maturation|T-lymphocyte secretory granule organization|T cell secretory granule organization and biogenesis|T cell secretory granule organisation|T-cell secretory granule organization biological_process owl:Class
GO:0033363 biolink:NamedThing secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. got7fsn_ti secretory granule organisation|secretory granule organization and biogenesis biological_process owl:Class
GO:0030900 biolink:NamedThing forebrain development The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). got7fsn_ti prosencephalon development biological_process owl:Class
GO:0055121 biolink:NamedThing response to high fluence blue light stimulus by blue high-fluence system Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a high fluence blue light stimulus by the blue high-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue high-fluence system responds to blue light at levels between 100 and 1000 micromols/m2. got7fsn_ti response to high fluence blue light|response to high fluence blue light by bhf system biological_process owl:Class
GO:0009637 biolink:NamedThing response to blue light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. got7fsn_ti response to blue light stimulus biological_process owl:Class
GO:0045013 biolink:NamedThing carbon catabolite repression of transcription A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. got7fsn_ti negative regulation of transcription by carbon catabolites|carbon catabolite repression biological_process owl:Class
GO:0045892 biolink:NamedThing negative regulation of transcription, DNA-templated Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. got7fsn_ti negative regulation of gene-specific transcription|downregulation of gene-specific transcription|negative regulation of cellular transcription, DNA-dependent|transcription repressor activity|inhibition of transcription, DNA-dependent|downregulation of transcription, DNA-dependent|down regulation of transcription, DNA-dependent|down-regulation of gene-specific transcription|inhibition of gene-specific transcription|down-regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|down regulation of gene-specific transcription GO:0016481|GO:0061021|GO:0032582 biological_process owl:Class
GO:0035799 biolink:NamedThing ureter maturation A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. got7fsn_ti bf 2011-04-14T01:13:39Z biological_process owl:Class
GO:0048799 biolink:NamedThing animal organ maturation A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions. got7fsn_ti biological_process owl:Class
GO:0048789 biolink:NamedThing cytoskeletal matrix organization at active zone The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane. got7fsn_ti cytoskeletal matrix organisation at active zone biological_process owl:Class
GO:0030865 biolink:NamedThing cortical cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane. got7fsn_ti cortical cytoskeleton organization and biogenesis|cortical cytoskeleton organisation biological_process owl:Class
GO:0071668 biolink:NamedThing plant-type cell wall assembly The aggregation, arrangement and bonding together of a set of components to form a cellulose- and pectin-containing cell wall. got7fsn_ti plant cell wall assembly mah 2010-02-15T02:19:39Z biological_process owl:Class
GO:0070726 biolink:NamedThing cell wall assembly The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells. got7fsn_ti mah 2009-06-16T03:58:20Z biological_process owl:Class
GO:0085039 biolink:NamedThing hyphal membrane A host-derived membrane surrounding the symbiont hypha during infection. got7fsn_ti extra-invasive hyphal membrane https://github.com/geneontology/go-ontology/issues/19013 jl 2010-07-27T04:19:46Z cellular_component owl:Class
GO:0033644 biolink:NamedThing host cell membrane Double layer of lipid molecules as it encloses host cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cellular_component owl:Class
GO:0072154 biolink:NamedThing proximal convoluted tubule segment 1 cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an S1 cell in the kidney. got7fsn_ti S1 cell fate commitment mah 2010-02-24T02:18:19Z biological_process owl:Class
GO:0045165 biolink:NamedThing cell fate commitment The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. got7fsn_ti Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. biological_process owl:Class
GO:0051332 biolink:NamedThing meiotic S phase The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle. got7fsn_ti S phase of meiotic cell cycle|S-phase of meiotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0051320 biolink:NamedThing S phase The cell cycle phase, following G1, during which DNA synthesis takes place. got7fsn_ti S-phase Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:S_phase biological_process owl:Class
GO:0036268 biolink:NamedThing swimming Self-propelled movement of an organism from one location to another through water, often by means of active fin movement. got7fsn_ti For behavioral aspects of swimming, consider instead annotating to 'swimming behavior ; GO:0036269'. bf 2012-07-04T10:12:24Z biological_process owl:Class
GO:0040011 biolink:NamedThing locomotion Self-propelled movement of a cell or organism from one location to another. got7fsn_ti biological_process owl:Class
GO:0090326 biolink:NamedThing positive regulation of locomotion involved in locomotory behavior Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. got7fsn_ti tb 2010-05-14T10:26:58Z biological_process owl:Class
GO:0040017 biolink:NamedThing positive regulation of locomotion Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism. got7fsn_ti activation of locomotion|up regulation of locomotion|up-regulation of locomotion|stimulation of locomotion|upregulation of locomotion biological_process owl:Class
GO:0070054 biolink:NamedThing mRNA splicing, via endonucleolytic cleavage and ligation Splicing of mRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. got7fsn_ti cytosolic mRNA splicing Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. GO:0061012 biological_process owl:Class
GO:0000394 biolink:NamedThing RNA splicing, via endonucleolytic cleavage and ligation Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. got7fsn_ti mRNA splicing Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. biological_process owl:Class
GO:0015026 biolink:NamedThing coreceptor activity Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. got7fsn_ti coreceptor, soluble ligand activity|coreceptor, insoluble ligand activity GO:0015028|GO:0015027 molecular_function owl:Class
GO:0038023 biolink:NamedThing signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. got7fsn_ti receptor activity|signalling receptor activity|receptor activity involved in signal transduction bf 2011-08-01T02:45:27Z GO:0019041|GO:0004872 molecular_function owl:Class
GO:0042318 biolink:NamedThing penicillin biosynthetic process The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. got7fsn_ti penicillin formation|penicillin anabolism|penicillin biosynthesis|penicillin synthesis biological_process owl:Class
GO:0044629 biolink:NamedThing negative regulation of complement activation, classical pathway in other organism Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism. got7fsn_ti jl 2012-07-05T01:03:25Z biological_process owl:Class
GO:0045959 biolink:NamedThing negative regulation of complement activation, classical pathway Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway. got7fsn_ti inhibition of complement activation, classical pathway|negative regulation of complement cascade, classical pathway|downregulation of complement activation, classical pathway|down regulation of complement activation, classical pathway|down-regulation of complement activation, classical pathway biological_process owl:Class
GO:0048933 biolink:NamedThing afferent axon development in posterior lateral line nerve The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0048893 biolink:NamedThing afferent axon development in lateral line nerve The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0004379 biolink:NamedThing glycylpeptide N-tetradecanoyltransferase activity Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. got7fsn_ti N-myristoyltransferase activity|protein N-myristoyltransferase activity|peptide N-tetradecanoyltransferase activity|myristoyl-CoA-protein N-myristoyltransferase activity|tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity|myristoylating enzymes|peptide N-myristoyltransferase activity|myristoyl-coenzyme A:protein N-myristoyl transferase activity GO:0019106 Reactome:R-HSA-184392|Reactome:R-HSA-2534087|MetaCyc:2.3.1.97-RXN|RHEA:15521|EC:2.3.1.97 molecular_function owl:Class
GO:0016410 biolink:NamedThing N-acyltransferase activity Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. got7fsn_ti Reactome:R-HSA-177160 molecular_function owl:Class
GO:0000920 biolink:NamedThing septum digestion after cytokinesis The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. got7fsn_ti mitotic cytokinetic cell separation|cell separation following cytokinesis|cytokinetic cell separation|daughter cell separation|cell separation after cytokinesis This term should not be used to describe the last step of cytokinesis in organisms without a cell wall, ie, the cell resealing of the plasma membrane via abscission. Consider annotating to 'GO:0061952 midbody abscission' to capture this process. GO:1902409|GO:2000695 biological_process owl:Class
GO:0009987 biolink:NamedThing cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. got7fsn_ti cell growth and/or maintenance|single-organism cellular process|cellular physiological process|cell physiology jl 2012-12-11T16:56:55Z GO:0044763|GO:0050875|GO:0008151 biological_process owl:Class
GO:0070004 biolink:NamedThing cysteine-type exopeptidase activity Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. got7fsn_ti molecular_function owl:Class
GO:0008238 biolink:NamedThing exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. got7fsn_ti exoprotease activity molecular_function owl:Class
GO:0071170 biolink:NamedThing site-specific DNA replication termination A DNA replication termination process that takes place at a specific termination site. got7fsn_ti See also the biological process term 'replication fork arrest ; GO:0043111' and its children. mah 2009-11-20T01:07:30Z biological_process owl:Class
GO:0006274 biolink:NamedThing DNA replication termination The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. got7fsn_ti biological_process owl:Class
GO:0034321 biolink:NamedThing alcohol O-octanoyltransferase activity Catalysis of the reaction: octanoyl-CoA + an alcohol = CoA + an octyl ester. got7fsn_ti molecular_function owl:Class
GO:0016413 biolink:NamedThing O-acetyltransferase activity Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0051263 biolink:NamedThing microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain. got7fsn_ti microcin E492 synthesis by siderophore ester modification of peptidyl-serine|microcin E492 anabolism by siderophore ester modification of peptidyl-serine|microcin E492 formation by siderophore ester modification of peptidyl-serine RESID:AA0374 biological_process owl:Class
GO:0018209 biolink:NamedThing peptidyl-serine modification The modification of peptidyl-serine. got7fsn_ti biological_process owl:Class
GO:0047791 biolink:NamedThing cucurbitacin delta23-reductase activity Catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+. got7fsn_ti cucurbitacin D23-reductase activity|NAD(P)H: cucurbitacin B delta23-oxidoreductase activity|23,24-dihydrocucurbitacin:NAD(P)+ delta23-oxidoreductase activity|cucurbitacin delta(23) reductase activity EC:1.3.1.5|MetaCyc:CUCURBITACIN-DELTA-23-REDUCTASE-RXN molecular_function owl:Class
GO:0016628 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti Reactome:R-HSA-9661745|Reactome:R-HSA-4419979|EC:1.3.1.-|Reactome:R-HSA-9661726|Reactome:R-HSA-4755572 molecular_function owl:Class
GO:0102616 biolink:NamedThing oryzalexin A synthase activity Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin A + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-15464 molecular_function owl:Class
GO:0021819 biolink:NamedThing layer formation in cerebral cortex The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. got7fsn_ti cerebral cortex lamination biological_process owl:Class
GO:0048646 biolink:NamedThing anatomical structure formation involved in morphogenesis The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti formation of an anatomical structure involved in morphogenesis Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. biological_process owl:Class
GO:0001306 biolink:NamedThing age-dependent response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism. got7fsn_ti biological_process owl:Class
GO:0006979 biolink:NamedThing response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. got7fsn_ti biological_process owl:Class
GO:0050261 biolink:NamedThing ribose isomerase activity Catalysis of the reaction: ribofuranose = D-ribulose. got7fsn_ti D-ribose isomerase activity|D-ribose ketol-isomerase activity|D-ribose aldose-ketose-isomerase activity MetaCyc:RIBOSE-ISOMERASE-RXN|KEGG_REACTION:R01081|RHEA:20796|EC:5.3.1.20 molecular_function owl:Class
GO:0016861 biolink:NamedThing intramolecular oxidoreductase activity, interconverting aldoses and ketoses Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. got7fsn_ti intramolecular isomerase activity, interconverting aldoses and ketoses EC:5.3.1.- molecular_function owl:Class
GO:1990756 biolink:NamedThing ubiquitin ligase-substrate adaptor activity The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins. got7fsn_ti protein binding, bridging involved in substrate recognition for ubiquitination|ubiquitin ligase substrate adaptor https://github.com/geneontology/go-ontology/issues/18655 vw 2015-06-01T08:35:16Z molecular_function owl:Class
GO:0030674 biolink:NamedThing protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. got7fsn_ti protein binding, bridging|protein-protein adaptor https://github.com/geneontology/go-ontology/issues/19409|https://github.com/geneontology/go-ontology/issues/18655 molecular_function owl:Class
GO:0004990 biolink:NamedThing oxytocin receptor activity Combining with oxytocin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0008528 biolink:NamedThing G protein-coupled peptide receptor activity Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti peptide receptor activity, G protein coupled|peptide receptor activity, G-protein coupled|G-protein coupled peptide receptor activity|G protein coupled peptide receptor activity molecular_function owl:Class
GO:0140317 biolink:NamedThing export across cell outer membrane The directed movement of a substance across the outer membrane in cells with two membranes. got7fsn_ti pg 2019-04-01T08:12:23Z biological_process owl:Class
GO:0055085 biolink:NamedThing transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti membrane transport|ATP hydrolysis coupled transmembrane transport Transmembrane transport is the transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. tb 2015-10-21T13:22:47Z GO:0090662 biological_process owl:Class
GO:0072559 biolink:NamedThing NLRP3 inflammasome complex An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. got7fsn_ti NALP3 inflammasome complex mah 2011-01-27T12:04:30Z cellular_component owl:Class
GO:0043761 biolink:NamedThing archaetidylserine synthase activity Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP. got7fsn_ti CDP-2,3-di-O-geranylgeranyl-sn-glycerol inositol 1-archaetidyltransferase activity|CDP-2,3-di-O-geranylgeranyl-sn-glycerol:l-serine O-archaetidyltransferase activity EC:2.7.8.38 molecular_function owl:Class
GO:0016780 biolink:NamedThing phosphotransferase activity, for other substituted phosphate groups Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). got7fsn_ti Reactome:R-HSA-162742|Reactome:R-HSA-163069|EC:2.7.8.- molecular_function owl:Class
GO:0000783 biolink:NamedThing nuclear telomere cap complex A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. got7fsn_ti Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. cellular_component owl:Class
GO:0000782 biolink:NamedThing telomere cap complex A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. got7fsn_ti Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. cellular_component owl:Class
GO:0102657 biolink:NamedThing 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.42|MetaCyc:RXN-1728 molecular_function owl:Class
GO:0016717 biolink:NamedThing oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. got7fsn_ti EC:1.14.19.- molecular_function owl:Class
GO:0048733 biolink:NamedThing sebaceous gland development The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0048732 biolink:NamedThing gland development The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. got7fsn_ti biological_process owl:Class
GO:0035185 biolink:NamedThing preblastoderm mitotic cell cycle The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. got7fsn_ti biological_process owl:Class
GO:0045448 biolink:NamedThing mitotic cell cycle, embryonic The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo. got7fsn_ti biological_process owl:Class
GO:0103057 biolink:NamedThing gibberellin A19, 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A19 + O2 + 2-oxoglutarate <=> H+ + gibberellin A20 + 2 carbon dioxide + succinate. got7fsn_ti MetaCyc:RXN1F-169 molecular_function owl:Class
GO:0016706 biolink:NamedThing 2-oxoglutarate-dependent dioxygenase activity Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. got7fsn_ti 2-oxoglutarate dioxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0010302 Reactome:R-HSA-1234164|Reactome:R-HSA-6783455|EC:1.14.11.- molecular_function owl:Class
GO:0036450 biolink:NamedThing polyuridylation-dependent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end. got7fsn_ti uridylation-dependent decapping of nuclear-transcribed mRNA bf 2013-11-04T11:37:28Z biological_process owl:Class
GO:0031087 biolink:NamedThing deadenylation-independent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening. got7fsn_ti deadenylation-independent decapping of nuclear mRNA|deadenylylation-independent decapping biological_process owl:Class
GO:0022406 biolink:NamedThing membrane docking The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere. got7fsn_ti membrane docking biological_process owl:Class
GO:0003332 biolink:NamedThing negative regulation of extracellular matrix constituent secretion Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. got7fsn_ti dph 2009-11-02T02:13:49Z biological_process owl:Class
GO:1903054 biolink:NamedThing negative regulation of extracellular matrix organization Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization. got7fsn_ti downregulation of extracellular matrix organisation|downregulation of extracellular matrix organization|down regulation of extracellular matrix organization|downregulation of extracellular matrix organization and biogenesis|down regulation of extracellular matrix organisation|down regulation of extracellular matrix organization and biogenesis|inhibition of extracellular matrix organization and biogenesis|inhibition of extracellular matrix organisation|negative regulation of extracellular matrix organization and biogenesis|negative regulation of extracellular matrix organisation|down-regulation of extracellular matrix organisation|down-regulation of extracellular matrix organization|inhibition of extracellular matrix organization|down-regulation of extracellular matrix organization and biogenesis rl 2014-05-23T17:15:47Z biological_process owl:Class
GO:0015474 biolink:NamedThing autotransporter activity Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively. got7fsn_ti molecular_function owl:Class
GO:0015288 biolink:NamedThing porin activity Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. got7fsn_ti porin|outer membrane exporter porin Wikipedia:Porin_(protein) molecular_function owl:Class
GO:0018546 biolink:NamedThing nitrobenzene nitroreductase activity Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O. got7fsn_ti MetaCyc:RXN-8815|RHEA:52884|UM-BBD_enzymeID:e0245 molecular_function owl:Class
GO:0016657 biolink:NamedThing oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group. got7fsn_ti oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor EC:1.6.6.- molecular_function owl:Class
GO:0002301 biolink:NamedThing CD4-positive, alpha-beta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti CD4-positive, alpha-beta intraepithelial T-cell differentiation|CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation|CD4-positive, alpha-beta intraepithelial T cell development|CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0044468 biolink:NamedThing envenomation resulting in modulation of blood coagulation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism. got7fsn_ti envenomation resulting in regulation of blood coagulation in other organism jl 2012-01-19T01:24:10Z biological_process owl:Class
GO:0035738 biolink:NamedThing envenomation resulting in modulation of process in other organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism. got7fsn_ti envenomation resulting in modification of morphology or physiology of other organism https://github.com/geneontology/go-ontology/issues/18605 bf 2011-03-17T10:59:27Z biological_process owl:Class
GO:0007019 biolink:NamedThing microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a microtubule. got7fsn_ti microtubule depolymerization during nuclear congression|microtubule catastrophe|microtubule shortening|microtubule disassembly biological_process owl:Class
GO:0031109 biolink:NamedThing microtubule polymerization or depolymerization Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule. got7fsn_ti biological_process owl:Class
GO:0035615 biolink:NamedThing clathrin adaptor activity Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles. got7fsn_ti clathrin-associated adaptor activity bf 2010-12-01T11:17:57Z molecular_function owl:Class
GO:0140312 biolink:NamedThing cargo adaptor activity Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery. got7fsn_ti endocytic adaptor activity https://github.com/geneontology/go-ontology/issues/19454|https://github.com/geneontology/go-ontology/issues/17553 pg 2019-03-26T17:01:45Z GO:0098748 molecular_function owl:Class
GO:0061049 biolink:NamedThing cell growth involved in cardiac muscle cell development The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. got7fsn_ti cardiomyocyte growth|heart muscle cell growth|cardiac muscle cell hypertrophy dph 2010-02-25T12:56:07Z biological_process owl:Class
GO:0048588 biolink:NamedThing developmental cell growth The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another. got7fsn_ti developmental growth of a unicellular organism biological_process owl:Class
GO:0044174 biolink:NamedThing host cell endosome A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation. got7fsn_ti host endosome jl 2009-09-04T03:02:01Z cellular_component owl:Class
GO:0033648 biolink:NamedThing host intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, as found in host cells, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti host intracellular membrane-enclosed organelle cellular_component owl:Class
GO:0060364 biolink:NamedThing frontal suture morphogenesis The process in which the frontal suture is generated and organized. got7fsn_ti interfrontal suture morphogenesis biological_process owl:Class
GO:0060363 biolink:NamedThing cranial suture morphogenesis The process in which any suture between cranial bones is generated and organized. got7fsn_ti biological_process owl:Class
GO:0052792 biolink:NamedThing endo-xylogalacturonan hydrolase activity Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position. got7fsn_ti endo-galacturonase activity ai 2011-10-05T03:57:30Z molecular_function owl:Class
GO:0043426 biolink:NamedThing MRF binding Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. got7fsn_ti myogenin binding|Myf5 binding|MyoD binding|Mrf4 binding GO:0051577|GO:0051579|GO:0051576|GO:0051578 molecular_function owl:Class
GO:0043425 biolink:NamedThing bHLH transcription factor binding Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. got7fsn_ti molecular_function owl:Class
GO:0048160 biolink:NamedThing primary follicle stage The stage in oogenesis when a single layer of cuboidal follicle cells surrounds the oocyte. The oocyte nucleus is large. got7fsn_ti mammalian oogenesis stage 3 biological_process owl:Class
GO:0022605 biolink:NamedThing mammalian oogenesis stage A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell. got7fsn_ti mammalian oogenesis process biological_process owl:Class
GO:0034746 biolink:NamedThing APC-IQGAP1-CLIP-170 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and CLIP-170; may play a role in cytoskeleton organization and cell migration. got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0050021 biolink:NamedThing L-arabinonolactonase activity Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+). got7fsn_ti L-arabinono-1,4-lactone lactonohydrolase activity EC:3.1.1.15|RHEA:16217|MetaCyc:L-ARABINONOLACTONASE-RXN|KEGG_REACTION:R02526 molecular_function owl:Class
GO:0052689 biolink:NamedThing carboxylic ester hydrolase activity Catalysis of the hydrolysis of a carboxylic ester bond. got7fsn_ti carboxylic acid esterase activity|vitamin A esterase|carboxyesterase activity|carboxylic esterase activity|carboxyl ester hydrolase activity|alpha-carboxylesterase activity|cocaine esterase activity|esterase B|procaine esterase activity|serine esterase activity|B-esterase activity|triacetin esterase|ali-esterase activity|carboxylate esterase activity|nonspecific carboxylesterase activity|carboxylesterase activity|carboxylic ester hydrolase activity|esterase A GO:0004759|GO:0004302|GO:0016789|GO:0004091 UM-BBD_reactionID:r1025|RHEA:21164|Reactome:R-HSA-5693691|EC:3.1.1.1|KEGG_REACTION:R00630|MetaCyc:CARBOXYLESTERASE-RXN|Reactome:R-HSA-9619024|Reactome:R-HSA-8937442 molecular_function owl:Class
GO:0034640 biolink:NamedThing establishment of mitochondrion localization by microtubule attachment The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization. got7fsn_ti mitochondrial localization by microtubule attachment|establishment of mitochondrion localisation by microtubule attachment|mitochondrial migration by microtubule attachment|mitochondrion migration by microtubule attachment biological_process owl:Class
GO:0034643 biolink:NamedThing establishment of mitochondrion localization, microtubule-mediated The directed movement of the mitochondrion to a specific location, by a process involving microtubules. got7fsn_ti establishment of mitochondrion localisation, microtubule-mediated|mitochondrial localization, microtubule-mediated|microtubule-mediated mitochondrion localization biological_process owl:Class
GO:0002097 biolink:NamedThing tRNA wobble base modification The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified. got7fsn_ti biological_process owl:Class
GO:0006400 biolink:NamedThing tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. got7fsn_ti tRNA editing The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. GO:0016549 biological_process owl:Class
GO:0050461 biolink:NamedThing L-mimosine synthase activity Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate. got7fsn_ti O3-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl)|O3-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity|3-O-acetyl-L-serine:3,4-dihydroxypyridine 1-(2-amino-2-carboxyethyl)transferase activity|O(3)-acetyl-L-serine acetate-lyase (adding 3,4-dihydroxypyridin-1-yl) activity EC:2.5.1.52|KEGG_REACTION:R04091|RHEA:12693|MetaCyc:RXN-7461 molecular_function owl:Class
GO:0016765 biolink:NamedThing transferase activity, transferring alkyl or aryl (other than methyl) groups Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring alkyl or aryl groups, other than methyl groups GO:0016766 Reactome:R-HSA-4755545|EC:2.5.1.-|Reactome:R-HSA-6782893|Reactome:R-HSA-4419978 molecular_function owl:Class
GO:0000774 biolink:NamedThing adenyl-nucleotide exchange factor activity Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. got7fsn_ti Reactome:R-HSA-5252079 molecular_function owl:Class
GO:0060590 biolink:NamedThing ATPase regulator activity Binds to and modulates the activity of an ATP hydrolysis activity. got7fsn_ti ATP hydrolysis regulator activity https://github.com/geneontology/go-ontology/issues/20955 dph 2009-05-08T02:49:24Z molecular_function owl:Class
GO:0106166 biolink:NamedThing spindle pole body-nuclear membrane anchor activity The binding activity of a molecule that brings together a mitotic spindle pole body and the nuclear membrane, in order to maintain specific membrane location of the spindle pole body. got7fsn_ti spindle pole body nuclear membrane anchor activity|nuclear membrane-spindle pole body anchor activity https://github.com/geneontology/go-ontology/issues/20606|https://github.com/geneontology/go-ontology/issues/19119 hjd 2019-01-18T15:57:42Z molecular_function owl:Class
GO:0140475 biolink:NamedThing spindle pole body anchor activity The binding activity of a protein that brings together the spindle pole body and one or more other molecules, permitting them to function in a coordinated way. got7fsn_ti pg 2020-06-23T15:54:56Z molecular_function owl:Class
GO:0061421 biolink:NamedThing positive regulation of transcription by oleic acid Any process involving oleic acid that activates or increases the rate of transcription. got7fsn_ti dph 2012-01-25T10:11:39Z biological_process owl:Class
GO:0045991 biolink:NamedThing carbon catabolite activation of transcription A transcription regulation process in which the presence of one carbon source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. got7fsn_ti positive regulation of transcription by carbon catabolites biological_process owl:Class
GO:0019250 biolink:NamedThing aerobic cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen. got7fsn_ti aerobic cobalamin formation|cobalamin biosynthesis, aerobic|vitamin B12 biosynthetic process, aerobic|aerobic cobalamin anabolism|aerobic cobalamin biosynthesis|cobalamin biosynthetic process, aerobic|vitamin B12 biosynthesis, aerobic|aerobic vitamin B12 biosynthetic process|aerobic vitamin B12 biosynthesis|aerobic cobalamin synthesis MetaCyc:P381-PWY biological_process owl:Class
GO:0009236 biolink:NamedThing cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. got7fsn_ti vitamin B12 biosynthesis|cobalamin biosynthesis|vitamin B12 biosynthetic process|cobalamin formation|cobalamin anabolism|cobalamin synthesis biological_process owl:Class
GO:0000159 biolink:NamedThing protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. got7fsn_ti PP2A-pi|protein phosphatase 2 complex|PP2a-protector|PP2A complex cellular_component owl:Class
GO:0008287 biolink:NamedThing protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. got7fsn_ti cellular_component owl:Class
GO:0102402 biolink:NamedThing 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity Catalysis of the reaction: 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside + H2O = 2-phenylethanol + 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose. got7fsn_ti MetaCyc:RXN-13694|EC:3.2.1.149 molecular_function owl:Class
GO:0017151 biolink:NamedThing DEAD/H-box RNA helicase binding Binding to a DEAD/H-box RNA helicase. got7fsn_ti molecular_function owl:Class
GO:0019899 biolink:NamedThing enzyme binding Binding to an enzyme, a protein with catalytic activity. got7fsn_ti molecular_function owl:Class
GO:0052092 biolink:NamedThing positive regulation by symbiont of nutrient release from host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti stimulation by symbiont of nutrient release from host|activation by symbiont of nutrient release from host|promotion of nutrient release from host|up-regulation by symbiont of nutrient release from host|upregulation by symbiont of nutrient release from host|up regulation by symbiont of nutrient release from host biological_process owl:Class
GO:0052520 biolink:NamedThing positive regulation by organism of nutrient release from other organism involved in symbiotic interaction Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti positive regulation by organism of nutrient release from other organism during symbiotic interaction|promotion of nutrient release from other organism|stimulation by organism of nutrient release from other organism during symbiotic interaction|activation by organism of nutrient release from other organism during symbiotic interaction|upregulation by organism of nutrient release from other organism during symbiotic interaction|up-regulation by organism of nutrient release from other organism during symbiotic interaction|up regulation by organism of nutrient release from other organism during symbiotic interaction biological_process owl:Class
GO:0047257 biolink:NamedThing diglucosyl diacylglycerol synthase activity Catalysis of the reaction: 1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol + UDP-D-glucose = UDP + 1,2-diacyl-3-O-(alpha-D-glucopyranosyl(1,2)-O-alpha-D-glucopyranosyl)-sn-glycerol. got7fsn_ti DGlcDAG synthase activity|monoglucosyl diacylglycerol (1->2) glucosyltransferase activity|MGlcDAG (1->2) glucosyltransferase activity|UDP-glucose:1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol (1->2) glucosyltransferase activity|diglucosyl diacylglycerol (DGlcDAG) synthase activity MetaCyc:2.4.1.208-RXN|RHEA:19165|EC:2.4.1.208 molecular_function owl:Class
GO:0008194 biolink:NamedThing UDP-glycosyltransferase activity Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. got7fsn_ti Reactome:R-HSA-162730 molecular_function owl:Class
GO:0043259 biolink:NamedThing laminin-10 complex A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains. got7fsn_ti laminin-511 complex cellular_component owl:Class
GO:0043256 biolink:NamedThing laminin complex A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes. got7fsn_ti cellular_component owl:Class
GO:1990447 biolink:NamedThing U2 snRNP binding Binding to a U2 small nuclear ribonucleoprotein particle. got7fsn_ti mah 2014-08-06T09:33:38Z molecular_function owl:Class
GO:0070990 biolink:NamedThing snRNP binding Binding to a small nuclear ribonucleoprotein particle. got7fsn_ti mah 2009-10-29T03:54:25Z molecular_function owl:Class
GO:0002261 biolink:NamedThing mucosal lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti biological_process owl:Class
GO:0002260 biolink:NamedThing lymphocyte homeostasis The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti biological_process owl:Class
GO:0022881 biolink:NamedThing protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti N-acetylgalactosamine PTS transporter activity molecular_function owl:Class
GO:0008982 biolink:NamedThing protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti phosphotransferase, phosphohistidinoprotein-hexose activity|gene glC proteins|protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity|phosphotransfer-driven group translocator|gene bglC RNA formation factors|PTS permease activity|protein-Np-phosphohistidine-sugar phosphotransferase activity|protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity|PTS transporter|phosphoenolpyruvate-sugar phosphotransferase enzyme II|sucrose phosphotransferase system II|protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity|ribonucleic acid formation factor, gene glC|phosphoprotein factor-hexose phosophotransferase activity|group translocator activity|enzyme II of the phosphotransferase system|PEP-dependent phosphotransferase enzyme II|phosphohistidinoprotein-hexose phosphotransferase activity|protein-Npi-phosphohistidine-sugar phosphotransferase activity|phosphohistidinoprotein-hexose phosphoribosyltransferase activity|enzyme IIl4ac|PEP--sugar phosphotransferase enzyme II activity|protein, specific or class, gene bglC GO:0015455|GO:0015456 MetaCyc:2.7.1.69-RXN|EC:2.7.1.69 molecular_function owl:Class
GO:1990147 biolink:NamedThing talin binding Binding to a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types. got7fsn_ti hjd 2013-07-25T19:49:53Z molecular_function owl:Class
GO:0008092 biolink:NamedThing cytoskeletal protein binding Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). got7fsn_ti molecular_function owl:Class
GO:0004517 biolink:NamedThing nitric-oxide synthase activity Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. got7fsn_ti endothelium-derived relaxing factor synthase activity|NO synthase activity|nitric oxide synthetase activity|nitric-oxide synthetase activity|NADPH-diaphorase activity|nitric oxide synthase activity|L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity|endothelium-derived relaxation factor-forming enzyme activity Reactome:R-HSA-418436|RHEA:19897|Reactome:R-HSA-202127|EC:1.14.13.39|MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN molecular_function owl:Class
GO:0140060 biolink:NamedThing axon arborization The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches. got7fsn_ti pg 2017-07-12T15:17:22Z biological_process owl:Class
GO:0007409 biolink:NamedThing axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells. got7fsn_ti axon morphogenesis|neuron long process generation|axon growth Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). GO:0007410 biological_process owl:Class
GO:0061778 biolink:NamedThing intracellular chloride channel activity Enables the transmembrane transfer of chloride across the membrane of an intracellular compartment. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. got7fsn_ti dph 2016-08-02T09:37:15Z molecular_function owl:Class
GO:0005254 biolink:NamedThing chloride channel activity Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti Reactome:R-HSA-975340|Reactome:R-HSA-975449|Reactome:R-HSA-427570|Reactome:R-HSA-2744349 molecular_function owl:Class
GO:0046917 biolink:NamedThing triphosphoribosyl-dephospho-CoA synthase activity Catalysis of the reaction: ATP + 3-dephospho-CoA = 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA + adenine. got7fsn_ti ATP:dephospho-CoA 5-triphosphoribosyl transferase activity|ATP:3-dephospho-CoA 5''-triphosphoribosyltransferase activity|CitG activity|2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase activity EC:2.4.2.52|RHEA:15117|MetaCyc:2.7.8.25-RXN molecular_function owl:Class
GO:0003222 biolink:NamedThing ventricular trabecula myocardium morphogenesis The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized. got7fsn_ti trabecula carnea morphogenesis dph 2009-10-13T10:33:00Z biological_process owl:Class
GO:0061384 biolink:NamedThing heart trabecula morphogenesis The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. got7fsn_ti dph 2010-12-02T08:54:20Z biological_process owl:Class
GO:0010196 biolink:NamedThing nonphotochemical quenching The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage. got7fsn_ti biological_process owl:Class
GO:1990066 biolink:NamedThing energy quenching The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence. got7fsn_ti tb 2013-03-27T21:02:00Z biological_process owl:Class
GO:0070669 biolink:NamedThing response to interleukin-2 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. got7fsn_ti response to IL-2 mah 2009-05-29T09:59:43Z biological_process owl:Class
GO:0034097 biolink:NamedThing response to cytokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. got7fsn_ti response to cytokine stimulus biological_process owl:Class
GO:1990768 biolink:NamedThing gastric mucosal blood circulation The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products. got7fsn_ti stomach mucosal blood circulation sl 2015-06-10T20:11:09Z biological_process owl:Class
GO:0008015 biolink:NamedThing blood circulation The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. got7fsn_ti hemolymph circulation GO:0070261 biological_process owl:Class
GO:0048584 biolink:NamedThing positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. got7fsn_ti activation of response to stimulus|stimulation of response to stimulus|up-regulation of response to stimulus|up regulation of response to stimulus|upregulation of response to stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0048583 biolink:NamedThing regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0006081 biolink:NamedThing cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. got7fsn_ti alkanal metabolic process|alkanal metabolism|aldehyde metabolism biological_process owl:Class
GO:0050984 biolink:NamedThing peptidyl-serine sulfation The sulfation of peptidyl-serine to form peptidyl-O-sulfo-L-serine. got7fsn_ti RESID:AA0361 biological_process owl:Class
GO:0070857 biolink:NamedThing regulation of bile acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. got7fsn_ti regulation of bile acid synthesis|regulation of bile acid biosynthesis|regulation of bile acid anabolism|regulation of bile acid formation mah 2009-08-14T03:09:02Z biological_process owl:Class
GO:0010565 biolink:NamedThing regulation of cellular ketone metabolic process Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. got7fsn_ti biological_process owl:Class
GO:0072297 biolink:NamedThing specification of metanephric proximal tubule identity The process in which the proximal tubule of the metanephric nephron acquires its identity. got7fsn_ti mah 2010-04-09T04:08:20Z biological_process owl:Class
GO:0031031 biolink:NamedThing positive regulation of septation initiation signaling Any process that activates or increases the frequency, rate or extent of septation initiation signaling. got7fsn_ti upregulation of septation initiation signaling|stimulation of septation initiation signaling|positive regulation of septation initiation signalling|positive regulation of septation initiation signaling cascade|up regulation of septation initiation signaling|up-regulation of septation initiation signaling|positive regulation of septation initiation network|activation of septation initiation signaling biological_process owl:Class
GO:0010973 biolink:NamedThing positive regulation of division septum assembly Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. got7fsn_ti positive regulation of division septum formation|positive regulation of division septum formation involved in cell cycle cytokinesis|upregulation of mitotic division septum assembly tb 2009-06-01T10:27:15Z GO:1901912|GO:1902470 biological_process owl:Class
GO:0070091 biolink:NamedThing glucagon secretion The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans). got7fsn_ti biological_process owl:Class
GO:0030072 biolink:NamedThing peptide hormone secretion The regulated release of a peptide hormone from a cell. got7fsn_ti biological_process owl:Class
GO:0043721 biolink:NamedThing 4-hydroxybutanoyl-CoA dehydratase activity Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O. got7fsn_ti gamma-hydroxybutyryl-CoA dehydratase activity|4-hydroxybutanoyl-CoA hydro-lyase|4-hydroxybutyryl-CoA dehydratase activity|gamma-hydroxybutanoyl-CoA dehydratase activity RHEA:26530|KEGG_REACTION:R05337|MetaCyc:RXN-8890|EC:4.2.1.120 molecular_function owl:Class
GO:0016836 biolink:NamedThing hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. got7fsn_ti Reactome:R-HSA-9014627|EC:4.2.1.- molecular_function owl:Class
GO:0060894 biolink:NamedThing limb spinous cell fate specification The process in which a cell becomes capable of differentiating autonomously into a limb spinous cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti dph 2009-08-13T01:46:23Z biological_process owl:Class
GO:0009957 biolink:NamedThing epidermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti hypodermal cell fate specification GO:0043356 biological_process owl:Class
GO:0090729 biolink:NamedThing toxin activity Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom. got7fsn_ti toxin receptor binding tb 2016-12-19T15:23:27Z GO:0050827 Wikipedia:Toxin molecular_function owl:Class
GO:0003674 biolink:NamedThing molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process. got7fsn_ti molecular function Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. GO:0005554 molecular_function owl:Class
GO:0007089 biolink:NamedThing traversing start control point of mitotic cell cycle A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity. got7fsn_ti GO:0000081 biological_process owl:Class
GO:1900087 biolink:NamedThing positive regulation of G1/S transition of mitotic cell cycle Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. got7fsn_ti activation of G1/S transition of mitotic cell cycle|up regulation of G1/S transition of mitotic cell cycle|up-regulation of G1/S transition of mitotic cell cycle|upregulation of G1/S transition of mitotic cell cycle rph 2012-02-08T12:24:39Z biological_process owl:Class
GO:0035116 biolink:NamedThing embryonic hindlimb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal. got7fsn_ti biological_process owl:Class
GO:0030326 biolink:NamedThing embryonic limb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. got7fsn_ti biological_process owl:Class
GO:0048462 biolink:NamedThing carpel formation The process that gives rise to the carpel. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048431 biological_process owl:Class
GO:0048449 biolink:NamedThing floral organ formation The process that gives rise to floral organs. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048436 biological_process owl:Class
GO:0003105 biolink:NamedThing negative regulation of glomerular filtration Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. got7fsn_ti biological_process owl:Class
GO:0051241 biolink:NamedThing negative regulation of multicellular organismal process Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. got7fsn_ti down regulation of multicellular organismal process|down-regulation of multicellular organismal process|downregulation of multicellular organismal process|inhibition of multicellular organismal process biological_process owl:Class
GO:0061760 biolink:NamedThing antifungal innate immune response An defense response against a fungus mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. got7fsn_ti dph 2016-03-07T08:53:08Z biological_process owl:Class
GO:0045087 biolink:NamedThing innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. got7fsn_ti nonspecific immune response|innate immunity GO:0002226 Wikipedia:Innate_immune_system biological_process owl:Class
GO:0019815 biolink:NamedThing B cell receptor complex An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti B lymphocyte receptor complex|immunoglobulin complex, membrane bound|BCR complex|B-lymphocyte receptor complex|antibody|B-cell receptor complex|B cell receptor accessory molecule complex Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. GO:0042570 cellular_component owl:Class
GO:0043235 biolink:NamedThing receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. got7fsn_ti cellular_component owl:Class
GO:0004689 biolink:NamedThing phosphorylase kinase activity Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. got7fsn_ti dephosphophosphorylase kinase activity|phosphorylase kinase (phosphorylating) activity|phosphorylase B kinase activity|phosphorylase kinase, intrinsic catalyst activity|glycogen phosphorylase kinase activity|PHK|STK17|ATP:phosphorylase-b phosphotransferase activity GO:0008606 Reactome:R-HSA-453337|Reactome:R-HSA-71541|Reactome:R-HSA-71588|MetaCyc:2.7.11.19-RXN|EC:2.7.11.19 molecular_function owl:Class
GO:0004683 biolink:NamedThing calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. got7fsn_ti multifunctional calcium- and calmodulin-regulated protein kinase activity|calcium- and calmodulin-dependent protein kinase activity|caldesmon kinase (phosphorylating) activity|CaMKKbeta|calcium/calmodulin-dependent protein kinase type II activity|calmodulin regulated protein kinase activity|CaM kinase II activity|calcium/calmodulin-dependent protein kinase activity|calmodulin-dependent protein kinase I activity|CaMKI|ATP:caldesmon O-phosphotransferase activity|multifunctional calcium/calmodulin regulated protein kinase activity|STK20|Ca2+/calmodulin-dependent protein kinase activity|Ca2+/calmodulin-dependent protein kinase IV activity|CAM PKII|CaMKKalpha|CaM-regulated serine/threonine kinase activity|CaM kinase activity|Ca2+/calmodulin-dependent protein kinase kinase beta activity|Ca2+/calmodulin-dependent protein kinase kinase activity|Ca2+/calmodulin-dependent protein kinase 1 activity|CaMKIV|CaMKII|calmodulin-dependent kinase II activity|Ca2+/CaM-dependent kinase activity|Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity|microtubule-associated protein 2 kinase activity|Ca2+/calmodulin-dependent protein kinase II activity|ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity These reactions require the presence of calcium-bound calmodulin. GO:0004685|GO:0004688|GO:0004684 Reactome:R-HSA-9619355|Reactome:R-HSA-9617583|Reactome:R-HSA-9619478|Reactome:R-HSA-9618750|Reactome:R-HSA-111912|Reactome:R-HSA-9619783|Reactome:R-HSA-111915|Reactome:R-HSA-9619367|MetaCyc:2.7.11.17-RXN|Reactome:R-HSA-416320|EC:2.7.11.17|Reactome:R-HSA-442749|Reactome:R-HSA-9006992|Reactome:R-HSA-9619125 molecular_function owl:Class
GO:0030050 biolink:NamedThing vesicle transport along actin filament Movement of a vesicle along an actin filament, mediated by motor proteins. got7fsn_ti biological_process owl:Class
GO:0030048 biolink:NamedThing actin filament-based movement Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins. got7fsn_ti biological_process owl:Class
GO:0097506 biolink:NamedThing deaminated base DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated bases. got7fsn_ti DNA glycosylase activity acting on deaminated bases|deaminated base DNA glycosylase activity pr 2013-09-26T16:00:40Z molecular_function owl:Class
GO:0019104 biolink:NamedThing DNA N-glycosylase activity Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. got7fsn_ti endonuclease VIII activity|DNA glycosylase activity GO:0008578 Reactome:R-HSA-9629149|Reactome:R-HSA-9636008|Reactome:R-HSA-110250|Reactome:R-HSA-110231|Reactome:R-HSA-5220959|Reactome:R-HSA-110234|Reactome:R-HSA-5649673|Reactome:R-HSA-110246|Reactome:R-HSA-9629497|Reactome:R-HSA-9635996|Reactome:R-HSA-110219|Reactome:R-HSA-110218|Reactome:R-HSA-110251|Reactome:R-HSA-9629483|Reactome:R-HSA-9629492|Reactome:R-HSA-110232|Reactome:R-HSA-5649664|Reactome:R-HSA-5649658|Reactome:R-HSA-5221061|Reactome:R-HSA-9629499|Reactome:R-HSA-9629470|Reactome:R-HSA-110248|Reactome:R-HSA-5649681|Reactome:R-HSA-9629216 molecular_function owl:Class
GO:0061269 biolink:NamedThing mesonephric glomerular mesangial cell proliferation involved in mesonephros development The multiplication or reproduction of glomerular mesangial cells in the mesonephros, resulting in the expansion of the population. got7fsn_ti dph 2010-08-30T03:20:57Z biological_process owl:Class
GO:0061209 biolink:NamedThing cell proliferation involved in mesonephros development The multiplication or reproduction of cells, resulting in the expansion of the population in the mesonephros. got7fsn_ti dph 2010-08-17T03:22:46Z biological_process owl:Class
GO:0047798 biolink:NamedThing cyclomaltodextrinase activity Catalysis of the reaction: H2O + cyclomaltodextrin = linear maltodextrin. got7fsn_ti cyclohexaglucanase activity|cyclodextrinase activity|cyclomaltodextrin dextrin-hydrolase (decyclizing)|cycloheptaglucanase activity MetaCyc:CYCLOMALTODEXTRINASE-RXN|RHEA:23980|EC:3.2.1.54 molecular_function owl:Class
GO:0034358 biolink:NamedThing plasma lipoprotein particle A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph. got7fsn_ti cellular_component owl:Class
GO:1990777 biolink:NamedThing lipoprotein particle A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph. got7fsn_ti pr 2015-06-18T08:42:53Z cellular_component owl:Class
GO:1990416 biolink:NamedThing cellular response to brain-derived neurotrophic factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus. got7fsn_ti cellular response to BDNF stimulus sl 2014-07-11T17:55:59Z biological_process owl:Class
GO:1990090 biolink:NamedThing cellular response to nerve growth factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. got7fsn_ti cellular response to NGF sl 2013-05-06T17:13:36Z biological_process owl:Class
GO:0006346 biolink:NamedThing DNA methylation-dependent heterochromatin assembly Repression of transcription by methylation of DNA, leading to the formation of heterochromatin. got7fsn_ti methylation-dependent heterochromatic silencing|methylation-dependent chromatin silencing https://github.com/geneontology/go-ontology/issues/22047 biological_process owl:Class
GO:0031507 biolink:NamedThing heterochromatin assembly An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation. got7fsn_ti establishment of heterochromatin architecture|chromatin-mediated silencing|establishment of heterochromatin architecture involved in chromatin silencing at pericentric region|establishment of chromatin silencing|establishment of heterochromatic silencing|heterochromatin formation|heterochromatin formation involved in chromatin silencing|chromatin silencing|TGS|heterochromatic silencing|heterochromatin assembly involved in chromatin silencing|heterochromatin assembly involved in chromatin silencing at pericentric region|transcriptional gene silencing|establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region|heterochromatin maintenance|heterochromatin formation involved in chromatin silencing at centromere outer repeat region|heterochromatin assembly involved in chromatin silencing at centromere outer repeat region|heterochromatin formation involved in chromatin silencing at pericentric region https://github.com/geneontology/go-ontology/issues/18954|https://github.com/geneontology/go-ontology/issues/22030|https://github.com/geneontology/go-ontology/issues/19112 GO:0006343|GO:1904497|GO:0016440|GO:0070869|GO:0006342 biological_process owl:Class
GO:0046666 biolink:NamedThing retinal cell programmed cell death Programmed cell death that occurs in the developing retina. got7fsn_ti retina programmed cell death|retina cell programmed cell death|retinal programmed cell death|programmed cell death, retinal cells|programmed cell death, retina cells biological_process owl:Class
GO:0098834 biolink:NamedThing presynaptic endocytic zone cytoplasmic component The cytoplasmic component of the presynaptic endocytic zone. got7fsn_ti cortex of presynaptic endocytic zone cellular_component owl:Class
GO:0099738 biolink:NamedThing cell cortex region The complete extent of cell cortex that underlies some some region of the plasma membrane. got7fsn_ti perimembrane region cellular_component owl:Class
GO:0102538 biolink:NamedThing UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-quinovosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-14767 molecular_function owl:Class
GO:0016623 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen. got7fsn_ti EC:1.2.3.- molecular_function owl:Class
GO:0016903 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors EC:1.2.-.- molecular_function owl:Class
GO:0075512 biolink:NamedThing clathrin-dependent endocytosis of virus by host cell Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus. got7fsn_ti viral entry into host cell via clathrin-mediated endocytosis|viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis|viral penetration via clathrin-mediated endocytosis|clathrin-mediated endocytosis of virus by host cell jl 2011-07-27T02:08:54Z GO:0075516 VZ:957 biological_process owl:Class
GO:0072583 biolink:NamedThing clathrin-dependent endocytosis An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. got7fsn_ti clathrin-mediated endocytosis|clathrin-dependent endocytosis|clathrin coated pit-dependent endocytosis|CME mah 2011-02-08T03:59:18Z biological_process owl:Class
GO:0060455 biolink:NamedThing negative regulation of gastric acid secretion Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. got7fsn_ti biological_process owl:Class
GO:0060453 biolink:NamedThing regulation of gastric acid secretion Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. got7fsn_ti biological_process owl:Class
GO:0021592 biolink:NamedThing fourth ventricle development The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space. got7fsn_ti biological_process owl:Class
GO:0044108 biolink:NamedThing cellular alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell. got7fsn_ti jl 2009-07-15T01:38:25Z biological_process owl:Class
GO:0044249 biolink:NamedThing cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. got7fsn_ti cellular formation|cellular synthesis|cellular biosynthesis|cellular anabolism biological_process owl:Class
GO:0048936 biolink:NamedThing peripheral nervous system neuron axonogenesis Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells. got7fsn_ti biological_process owl:Class
GO:0042465 biolink:NamedThing kinesis The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus. got7fsn_ti Wikipedia:Kinesis biological_process owl:Class
GO:0009605 biolink:NamedThing response to external stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. got7fsn_ti response to environmental stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0048639 biolink:NamedThing positive regulation of developmental growth Any process that activates, maintains or increases the rate of developmental growth. got7fsn_ti up-regulation of developmental growth|activation of developmental growth|upregulation of developmental growth|stimulation of developmental growth|up regulation of developmental growth biological_process owl:Class
GO:0045927 biolink:NamedThing positive regulation of growth Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism. got7fsn_ti stimulation of growth|upregulation of growth|up-regulation of growth|up regulation of growth|activation of growth biological_process owl:Class
GO:0045210 biolink:NamedThing FasL biosynthetic process The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines. got7fsn_ti FASLG biosynthetic process|FasL formation|CD95L biosynthetic process|APT1LG1 biosynthetic process|CD178 biosynthetic process|FasL synthesis|fas ligand biosynthetic process|CD95L biosynthesis|FasL anabolism|Fas-L biosynthetic process|FasL biosynthesis biological_process owl:Class
GO:0009101 biolink:NamedThing glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. got7fsn_ti glycoprotein biosynthesis|glycoprotein anabolism|glycoprotein synthesis|glycoprotein formation biological_process owl:Class
GO:0014010 biolink:NamedThing Schwann cell proliferation The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system. got7fsn_ti biological_process owl:Class
GO:0014009 biolink:NamedThing glial cell proliferation The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others. got7fsn_ti glia proliferation biological_process owl:Class
GO:0050742 biolink:NamedThing protein-FMN linkage via S-(4a-FMN)-L-cysteine The formation of a protein-FMN linkage via S-(4a-FMN)-L-cysteine. got7fsn_ti RESID:AA0351 biological_process owl:Class
GO:0018309 biolink:NamedThing protein-FMN linkage The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN). got7fsn_ti biological_process owl:Class
GO:0047224 biolink:NamedThing acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP. got7fsn_ti uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase activity|core 3-beta-GlcNAc-transferase activity|mucin core 3 beta3-GlcNAc-transferase activity|UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity|O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity|core 3beta-GlcNAc-transferase activity EC:2.4.1.147|RHEA:14252|MetaCyc:2.4.1.147-RXN molecular_function owl:Class
GO:0008375 biolink:NamedThing acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. got7fsn_ti GlcNAc transferase activity Reactome:R-HSA-9694656|Reactome:R-HSA-9683648|Reactome:R-HSA-5694487|Reactome:R-HSA-8879117 molecular_function owl:Class
GO:0061241 biolink:NamedThing mesonephric nephron epithelium development The process whose specific outcome is the progression of the mesonephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros. got7fsn_ti dph 2010-08-19T03:11:59Z biological_process owl:Class
GO:0072009 biolink:NamedThing nephron epithelium development The process whose specific outcome is the progression of the nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The nephron epithelium is a tissue that covers the surface of a nephron. got7fsn_ti mah 2010-01-25T02:01:39Z biological_process owl:Class
GO:0047041 biolink:NamedThing (S)-carnitine 3-dehydrogenase activity Catalysis of the reaction: (S)-carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH. got7fsn_ti (S)-carnitine:NAD+ oxidoreductase activity|D-carnitine dehydrogenase activity KEGG_REACTION:R01921|RHEA:11556|EC:1.1.1.254|MetaCyc:1.1.1.254-RXN molecular_function owl:Class
GO:0035186 biolink:NamedThing syncytial blastoderm mitotic cell cycle Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively. got7fsn_ti biological_process owl:Class
GO:0033301 biolink:NamedThing cell cycle comprising mitosis without cytokinesis A mitotic cell cycle in which mitosis is completed but cytokinesis does not occur, resulting in a cell containing multiple nuclei each with a chromosomal complement of the original ploidy (usually 2N). got7fsn_ti Note that this term should be used for naturally occurring instances of mitosis without cytokinesis, e.g. in the tapetum of flowers and in a number of lower eukaryotes; it should not be used for abnormal events such as may occur in cancers. biological_process owl:Class
GO:0008380 biolink:NamedThing RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. got7fsn_ti pre-mRNA splicing factor activity GO:0006395 Wikipedia:RNA_splicing biological_process owl:Class
GO:0006396 biolink:NamedThing RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. got7fsn_ti GO:0006394 Wikipedia:Post-transcriptional_modification biological_process owl:Class
GO:0099018 biolink:NamedThing restriction-modification system evasion by virus Any process, either active or passive, by which a virus evades the DNA restriction modification system of its host. Some viruses encode their own methyltransferase in order to protect their genome from host restriction enzymes. Others directly inhibit restruction enzymes while some use unusual bases in their genome to avoid restriction. got7fsn_ti VZ:3966 biological_process owl:Class
GO:0019049 biolink:NamedThing mitigation of host defenses by virus A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti evasion of host defenses by virus|viral host defence evasion|evasion or tolerance of host defenses by virus|viral host defense evasion biological_process owl:Class
GO:0090492 biolink:NamedThing N,N-Dihydroxy-L-tryptophan decarboxylase activity Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O. got7fsn_ti tb 2012-10-16T16:32:30Z molecular_function owl:Class
GO:0016831 biolink:NamedThing carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. got7fsn_ti decarboxylase activity EC:4.1.1.-|Reactome:R-HSA-6814165|Reactome:R-HSA-6787757|Reactome:R-HSA-71223 molecular_function owl:Class
GO:0047437 biolink:NamedThing 4-oxalocrotonate decarboxylase activity Catalysis of the reaction: 4-oxalocrotonate = CO2 + 2-oxopent-4-enoate. got7fsn_ti 4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming)|4-oxalocrotonate carboxy-lyase activity MetaCyc:4.1.1.77-RXN|UM-BBD_reactionID:r1435|RHEA:24260|EC:4.1.1.77 molecular_function owl:Class
GO:0002696 biolink:NamedThing positive regulation of leukocyte activation Any process that activates or increases the frequency, rate, or extent of leukocyte activation. got7fsn_ti positive regulation of leucocyte activation|upregulation of leukocyte activation|stimulation of leukocyte activation|activation of leukocyte activation|up regulation of leukocyte activation|up-regulation of leukocyte activation|positive regulation of immune cell activation biological_process owl:Class
GO:0050867 biolink:NamedThing positive regulation of cell activation Any process that activates or increases the frequency, rate or extent of activation. got7fsn_ti activation of cell activation|stimulation of cell activation|up regulation of cell activation|upregulation of cell activation|up-regulation of cell activation biological_process owl:Class
GO:0021821 biolink:NamedThing negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. got7fsn_ti down regulation of cell-glial cell adhesion involved in cerebral cortex lamination|down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination|downregulation of cell-glial cell adhesion involved in cerebral cortex lamination|inhibition of cell-glial cell adhesion involved in cerebral cortex lamination biological_process owl:Class
GO:0022408 biolink:NamedThing negative regulation of cell-cell adhesion Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell. got7fsn_ti down-regulation of cell-cell adhesion|downregulation of cell-cell adhesion|down regulation of cell-cell adhesion|inhibition of cell-cell adhesion biological_process owl:Class
GO:0022894 biolink:NamedThing Intermediate conductance calcium-activated potassium channel activity Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. got7fsn_ti IK KCa channels|IK calcium-activated potassium channel activity|intermdiate conductance KCa channels molecular_function owl:Class
GO:0015269 biolink:NamedThing calcium-activated potassium channel activity Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. got7fsn_ti molecular_function owl:Class
GO:0034524 biolink:NamedThing 2-hydroxyisophthalate decarboxylase activity Catalysis of the reaction: 2-hydroxyisophthalic acid = salicylate + CO2. got7fsn_ti UM-BBD_reactionID:r0776 molecular_function owl:Class
GO:0007008 biolink:NamedThing outer mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane. got7fsn_ti outer mitochondrial membrane organisation|outer mitochondrial membrane organization and biogenesis See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. biological_process owl:Class
GO:0007006 biolink:NamedThing mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion. got7fsn_ti mitochondrial membrane organisation|mitochondrial membrane organization and biogenesis biological_process owl:Class
GO:0044648 biolink:NamedThing histone H3-K4 dimethylation The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone. got7fsn_ti jl 2012-07-11T01:27:33Z biological_process owl:Class
GO:0051568 biolink:NamedThing histone H3-K4 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. got7fsn_ti histone H3 K4 methylation|histone H3K4me|histone lysine H3 K4 methylation biological_process owl:Class
GO:0035678 biolink:NamedThing neuromast hair cell morphogenesis The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. got7fsn_ti bf 2011-02-14T11:06:15Z biological_process owl:Class
GO:0048667 biolink:NamedThing cell morphogenesis involved in neuron differentiation The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron. got7fsn_ti neuron morphogenesis involved in differentiation biological_process owl:Class
GO:0075113 biolink:NamedThing induction by symbiont of host transmembrane receptor-mediated signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host transmembrane receptor-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075082". biological_process owl:Class
GO:0075110 biolink:NamedThing induction by symbiont of host receptor-mediated signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host receptor-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont receptor-mediated signal transduction ; GO:0075079". biological_process owl:Class
GO:1900611 biolink:NamedThing F-9775A biosynthetic process The chemical reactions and pathways resulting in the formation of F-9775A. got7fsn_ti F-9775A anabolism|F-9775A synthesis|F-9775A biosynthesis|F-9775A formation di 2012-05-15T07:02:56Z biological_process owl:Class
GO:0009719 biolink:NamedThing response to endogenous stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0050896 biolink:NamedThing response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. got7fsn_ti physiological response to stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0051869 biological_process owl:Class
GO:0098505 biolink:NamedThing G-rich strand telomeric DNA binding Binding to G-rich, single-stranded, telomere-associated DNA. got7fsn_ti dos 2013-09-23T13:16:24Z molecular_function owl:Class
GO:0043047 biolink:NamedThing single-stranded telomeric DNA binding Binding to single-stranded telomere-associated DNA. got7fsn_ti telomeric ssDNA binding molecular_function owl:Class
GO:0035284 biolink:NamedThing brain segmentation Division of the brain into a series of semi-repetitive parts or segments. got7fsn_ti biological_process owl:Class
GO:0035282 biolink:NamedThing segmentation The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis. got7fsn_ti Wikipedia:Segmentation_(biology) biological_process owl:Class
GO:0090647 biolink:NamedThing modulation of age-related behavioral decline Any process that modulates the processes that arise as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory. got7fsn_ti tb 2015-06-15T12:45:44Z biological_process owl:Class
GO:0002170 biolink:NamedThing high-affinity IgA receptor activity Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti high affinity IgA receptor activity hjd 2010-05-06T05:00:11Z molecular_function owl:Class
GO:0019766 biolink:NamedThing IgA receptor activity Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0048040 biolink:NamedThing UDP-glucuronate decarboxylase activity Catalysis of the reaction: H(+) + UDP-alpha-D-glucuronate = CO(2) + UDP-alpha-D-xylose. got7fsn_ti UDPglucuronate decarboxylase activity|UDP-glucuronic acid decarboxylase activity|uridine-diphosphoglucuronate decarboxylase activity|UDP-D-glucuronate carboxy-lyase activity|UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming) KEGG_REACTION:R01384|MetaCyc:UDP-GLUCURONATE-DECARBOXYLASE-RXN|RHEA:23916|EC:4.1.1.35 molecular_function owl:Class
GO:0101030 biolink:NamedThing tRNA-guanine transglycosylation The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine. got7fsn_ti biological_process owl:Class
GO:0018631 biolink:NamedThing phenylacetate hydroxylase activity Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate. got7fsn_ti UM-BBD_reactionID:r0036|EC:1.14.13.- molecular_function owl:Class
GO:0031269 biolink:NamedThing pseudopodium assembly The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane. got7fsn_ti pseudopodium formation|pseudopodium extension biological_process owl:Class
GO:0031268 biolink:NamedThing pseudopodium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement. got7fsn_ti pseudopodium organisation|pseudopodium organization and biogenesis biological_process owl:Class
GO:0038033 biolink:NamedThing positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis. got7fsn_ti VEGF-mediated chemotactic endothelial cell migration|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signalling pathway|positive regulation of endothelial cell chemotaxis by VEGF/VEGFR signaling pathway|VEGF-VEGFR-induced endothelial cell chemotaxis|vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis bf 2011-09-19T02:36:37Z biological_process owl:Class
GO:0048010 biolink:NamedThing vascular endothelial growth factor receptor signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGF receptor signaling pathway|VEGFR signaling pathway|VEGF receptor signalling pathway In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'. biological_process owl:Class
GO:0140405 biolink:NamedThing spindle pole body-led chromosome movement during mitotic interphase A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18373|https://github.com/geneontology/go-ontology/issues/19149 pg 2019-12-10T09:13:47Z biological_process owl:Class
GO:0051303 biolink:NamedThing establishment of chromosome localization The directed movement of a chromosome to a specific location. got7fsn_ti chromosome positioning|establishment of chromosome localisation biological_process owl:Class
GO:0102408 biolink:NamedThing sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate <=> coenzyme A + sn-2-C16:0-DCA-LPA. got7fsn_ti MetaCyc:RXN-13735 molecular_function owl:Class
GO:0018838 biolink:NamedThing mandelate racemase activity Catalysis of the reaction: (S)-mandelate = (R)-mandelate. got7fsn_ti RHEA:13945|EC:5.1.2.2|MetaCyc:MANDELATE-RACEMASE-RXN|UM-BBD_reactionID:r0091 molecular_function owl:Class
GO:0016856 biolink:NamedThing racemase and epimerase activity, acting on hydroxy acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule. got7fsn_ti EC:5.1.2.- molecular_function owl:Class
GO:0018159 biolink:NamedThing peptidyl-methionine oxidation The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone. got7fsn_ti RESID:AA0251 biological_process owl:Class
GO:0018206 biolink:NamedThing peptidyl-methionine modification The modification of peptidyl-methionine. got7fsn_ti biological_process owl:Class
GO:0007287 biolink:NamedThing Nebenkern assembly Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern. got7fsn_ti Nebenkern formation|Nebenkern assembly See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'. biological_process owl:Class
GO:0003006 biolink:NamedThing developmental process involved in reproduction A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. got7fsn_ti puberty|reproductive developmental process biological_process owl:Class
GO:0034533 biolink:NamedThing 1,2-dihydroxy-7-hydroxymethylnaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-7-hydroxymethylnaphthalene + O2 = 2-hydroxy-7-hydroxymethylchromene-2-carboxylate. got7fsn_ti UM-BBD_reactionID:r0764 molecular_function owl:Class
GO:0016701 biolink:NamedThing oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. got7fsn_ti oxygenase|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous EC:1.13.-.- molecular_function owl:Class
GO:0031173 biolink:NamedThing otolith mineralization completed early in development The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear. got7fsn_ti otoconia mineralization|otoconium mineralization biological_process owl:Class
GO:0045299 biolink:NamedThing otolith mineralization The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear. got7fsn_ti biological_process owl:Class
GO:0061362 biolink:NamedThing negative regulation of maintenance of bipolar cell polarity regulating cell shape Any process that decreases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape. got7fsn_ti dph 2010-10-13T09:03:42Z biological_process owl:Class
GO:2000115 biolink:NamedThing regulation of maintenance of bipolar cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape. got7fsn_ti dph 2010-09-21T06:33:26Z biological_process owl:Class
GO:0052891 biolink:NamedThing aliphatic (S)-hydroxynitrile lyase activity Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide. got7fsn_ti oxynitrilase activity|(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity|(S)-hydroxynitrile lyase activity|(S)-cyanohydrin producing hydroxynitrile lyase activity|(S)-oxynitrilase activity|(S)-selective hydroxynitrile lyase activity|hydroxynitrile lyase activity EC:4.1.2.47|MetaCyc:RXN-11731 molecular_function owl:Class
GO:0032919 biolink:NamedThing spermine acetylation The modification of spermine by addition of acetyl groups. got7fsn_ti biological_process owl:Class
GO:0032917 biolink:NamedThing polyamine acetylation The modification of polyamines by addition of acetyl groups. got7fsn_ti biological_process owl:Class
GO:0070227 biolink:NamedThing lymphocyte apoptotic process Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. got7fsn_ti lymphocyte apoptosis Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). biological_process owl:Class
GO:0071887 biolink:NamedThing leukocyte apoptotic process Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. got7fsn_ti leukocyte apoptosis Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). mah 2010-09-14T12:44:09Z biological_process owl:Class
GO:0033455 biolink:NamedThing GCA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCA codon. got7fsn_ti alanine tRNA Note that in the standard genetic code, GCA codes for alanine. molecular_function owl:Class
GO:0030533 biolink:NamedThing triplet codon-amino acid adaptor activity The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis. got7fsn_ti tRNA|transfer RNA Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. molecular_function owl:Class
GO:0050954 biolink:NamedThing sensory perception of mechanical stimulus The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti mechanosensory perception|perception of mechanical stimulus|chemi-mechanical coupling biological_process owl:Class
GO:0007600 biolink:NamedThing sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti Wikipedia:Perception biological_process owl:Class
GO:0001892 biolink:NamedThing embryonic placenta development The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. got7fsn_ti fetal placenta development biological_process owl:Class
GO:0048568 biolink:NamedThing embryonic organ development Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti embryonic organogenesis biological_process owl:Class
GO:0009639 biolink:NamedThing response to red or far red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti biological_process owl:Class
GO:0009416 biolink:NamedThing response to light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. got7fsn_ti biological_process owl:Class
GO:0018573 biolink:NamedThing 2-aminophenol 1,6-dioxygenase activity Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0305 molecular_function owl:Class
GO:0018596 biolink:NamedThing dimethylsilanediol hydroxylase activity Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol. got7fsn_ti DMSD hydroxylase activity UM-BBD_reactionID:r0637 molecular_function owl:Class
GO:0070467 biolink:NamedThing RC-1 DNA recombination complex A protein complex that contains DNA ligase III, DNA polymerase epsilon, a 5'-3' exonuclease, and the SMC1 and SMC2 proteins, and is involved in recombinational repair of deletions and gaps in DNA. got7fsn_ti RC-1 complex (recombination complex 1)|DNA recombination complex RC-1 cellular_component owl:Class
GO:0048071 biolink:NamedThing sex-specific pigmentation Establishment of a pattern of pigment in one sex that is not observed in the other sex. got7fsn_ti biological_process owl:Class
GO:0018477 biolink:NamedThing benzaldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+. got7fsn_ti benzaldehyde:NADP+ oxidoreductase|NADP-linked benzaldehyde dehydrogenase UM-BBD_enzymeID:e0079|MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN|EC:1.2.1.7|RHEA:21660 molecular_function owl:Class
GO:0033721 biolink:NamedThing aldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+. got7fsn_ti aldehyde:NADP+ oxidoreductase activity|NADP-acetaldehyde dehydrogenase activity|NADP-dependent aldehyde dehydrogenase activity RHEA:11888|EC:1.2.1.4|MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN molecular_function owl:Class
GO:0008481 biolink:NamedThing sphinganine kinase activity Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate. got7fsn_ti sphingosine kinase (phosphorylating)|sphingosine kinase activity|ATP:sphinganine 1-phosphotransferase activity|dihydrosphingosine kinase activity|dihydrosphingosine kinase (phosphorylating) GO:0001728 MetaCyc:SPHINGANINE-KINASE-RXN|RHEA:15465|Reactome:R-HSA-428214|EC:2.7.1.91 molecular_function owl:Class
GO:0001727 biolink:NamedThing lipid kinase activity Catalysis of the phosphorylation of a simple or complex lipid. got7fsn_ti molecular_function owl:Class
GO:0019253 biolink:NamedThing reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. got7fsn_ti Calvin cycle|C3 photosynthesis See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. MetaCyc:CALVIN-PWY biological_process owl:Class
GO:0019685 biolink:NamedThing photosynthesis, dark reaction A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions. got7fsn_ti biological_process owl:Class
GO:0031603 biolink:NamedThing cytosolic proteasome core complex The core complex of a proteasome located in the cytosol of a cell. got7fsn_ti cellular_component owl:Class
GO:0005839 biolink:NamedThing proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. got7fsn_ti 20S proteasome|20S core complex|macropain|PA28gamma-20S proteasome GO:0000503 cellular_component owl:Class
GO:0052344 biolink:NamedThing positive regulation by symbiont of host phytoalexin production Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by organism of phytoalexin production in other organism involved in symbiotic interaction|stimulation by symbiont of host phytoalexin production|upregulation by symbiont of host phytoalexin production|up-regulation by symbiont of host phytoalexin production|activation by symbiont of host phytoalexin production|up regulation by symbiont of host phytoalexin production GO:0052329 biological_process owl:Class
GO:0052559 biolink:NamedThing induction by symbiont of host immune response Any process in which a symbiont activates the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti activation by symbiont of host immune response|upregulation by symbiont of host immune response|positive regulation by symbiont of host immune response|up-regulation by symbiont of host immune response|positive regulation by organism of immune response of other organism involved in symbiotic interaction|induction by organism of immune response of other organism involved in symbiotic interaction|up regulation by symbiont of host immune response|stimulation by symbiont of host immune response GO:0052556|GO:0052558|GO:0052555 biological_process owl:Class
GO:0043870 biolink:NamedThing N-acetyl-gamma-aminoadipyl-phosphate reductase activity Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH. got7fsn_ti AGPR|ArgC|NAGSA dehydrogenase activity|LysY|N-acetyl-aminoadipate semialdehyde dehydrogenase activity|N-acetyl-alpha-glutamyl-phosphate reductase activity This function is part of the prokaryotic alpha-aminoadipate lysine biosynthesis pathway. RHEA:41948|MetaCyc:RXN-5183 molecular_function owl:Class
GO:0021832 biolink:NamedThing cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration. got7fsn_ti biological_process owl:Class
GO:0098742 biolink:NamedThing cell-cell adhesion via plasma-membrane adhesion molecules The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0036312 biolink:NamedThing phosphatidylinositol 3-kinase regulatory subunit binding Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. got7fsn_ti PI3K regulatory subunit binding|p85 binding bf 2012-08-16T10:58:45Z molecular_function owl:Class
GO:0043548 biolink:NamedThing phosphatidylinositol 3-kinase binding Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. got7fsn_ti PI3K binding|phosphoinositide 3-kinase binding molecular_function owl:Class
GO:0060085 biolink:NamedThing smooth muscle relaxation of the bladder outlet A process in which the extent of smooth muscle contraction is reduced in the bladder outlet that contributes to the expulsion of urine from the body. got7fsn_ti synaptic transmission involved in urination biological_process owl:Class
GO:0061206 biolink:NamedThing mesonephros morphogenesis The process in which the anatomical structures of the mesonephros are generated and organized. got7fsn_ti Wolffian body morphogenesis dph 2010-08-17T03:11:10Z biological_process owl:Class
GO:0060993 biolink:NamedThing kidney morphogenesis Morphogenesis of a kidney. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti dph 2010-01-19T08:16:55Z biological_process owl:Class
GO:0030186 biolink:NamedThing melatonin metabolic process The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine). got7fsn_ti melatonin metabolism biological_process owl:Class
GO:0042430 biolink:NamedThing indole-containing compound metabolic process The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. got7fsn_ti indole derivative metabolic process|indole derivative metabolism|indole and derivative metabolism|ketole metabolism|indole-containing compound metabolism|ketole metabolic process|indole and derivative metabolic process GO:0042434 biological_process owl:Class
GO:0033428 biolink:NamedThing CAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAG codon. got7fsn_ti glutamine tRNA Note that in the standard genetic code, CAG codes for glutamine. molecular_function owl:Class
GO:0044593 biolink:NamedThing iron-sulfur-molybdenum cofactor assembly The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase. got7fsn_ti iron molybdenum cofactor assembly|iron molybdenum cofactor biosynthesis|FeMoco biosynthetic process|iron molybdenum cofactor biosynthetic process|FeMoco assembly jl 2012-04-26T04:01:53Z biological_process owl:Class
GO:0016226 biolink:NamedThing iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. got7fsn_ti iron-sulphur cluster assembly|iron-sulfur cluster biosynthesis biological_process owl:Class
GO:0070254 biolink:NamedThing mucus secretion The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function. got7fsn_ti mucus production biological_process owl:Class
GO:0032941 biolink:NamedThing secretion by tissue The controlled release of a substance by a tissue. got7fsn_ti tissue secretion|expulsion of gland contents biological_process owl:Class
GO:0098966 biolink:NamedThing perisynaptic extracellular matrix The portion of the extracellular matrix that lies within the perisynaptic space. got7fsn_ti extrasynaptic extracellular matrix|perisynaptic ECM cellular_component owl:Class
GO:0062023 biolink:NamedThing collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. got7fsn_ti dph 2018-04-13T12:47:21Z cellular_component owl:Class
GO:0016746 biolink:NamedThing acyltransferase activity Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring acyl groups|acyltransferase activity https://github.com/geneontology/go-ontology/issues/20486 GO:0008415 Reactome:R-HSA-193491|EC:2.3.-.-|Reactome:R-HSA-159431|Reactome:R-HSA-192312|Reactome:R-HSA-8858298|Reactome:R-HSA-6792572 molecular_function owl:Class
GO:0018278 biolink:NamedThing N-terminal peptidyl-threonine deamination The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid. got7fsn_ti RESID:AA0129 biological_process owl:Class
GO:0018058 biolink:NamedThing N-terminal protein amino acid deamination, from amino carbon The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol. got7fsn_ti RESID:AA0127|RESID:AA0129|RESID:AA0128 biological_process owl:Class
GO:0099137 biolink:NamedThing altruistic, chimeric, non-reproductive fruiting body development Development of a chimeric, non-reproductive fruiting body in which cells of all genotypes have an equal chance of becoming a spore cell. got7fsn_ti fully co-operative, chimeric, non-reproductive fruiting body development biological_process owl:Class
GO:0099136 biolink:NamedThing chimeric non-reproductive fruiting body development Development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes. got7fsn_ti biological_process owl:Class
GO:0071720 biolink:NamedThing sodium-independent prostaglandin transport The directed, sodium-independent, movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti mah 2010-03-10T03:09:10Z biological_process owl:Class
GO:0071718 biolink:NamedThing sodium-independent icosanoid transport The directed, sodium-independent, movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. got7fsn_ti sodium-independent eicosanoid transport mah 2010-03-10T03:05:13Z biological_process owl:Class
GO:0071743 biolink:NamedThing IgE immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgE antibody Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0042571 biolink:NamedThing immunoglobulin complex, circulating An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. got7fsn_ti antibody Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Wikipedia:Antibody cellular_component owl:Class
GO:0052922 biolink:NamedThing hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate. got7fsn_ti hexaprenyl pyrophosphate synthetase activity|hexaprenyl diphosphate synthase activity|(all-trans)-hexaprenyl-diphosphate synthase activity|(all-E) hexaprenyl diphosphate synthase activity KEGG_REACTION:R09246|MetaCyc:RXN-11485|RHEA:27555|EC:2.5.1.82 molecular_function owl:Class
GO:0004659 biolink:NamedThing prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). got7fsn_ti MetaCyc:GPPSYN-RXN|Reactome:R-HSA-6806674 molecular_function owl:Class
GO:1902549 biolink:NamedThing protein localization to Mei2 nuclear dot A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot. got7fsn_ti protein localisation to Mei2 nuclear dot|protein localization in Mei2 nuclear dot|protein localization to Mei2 dot|protein localisation in Mei2 nuclear dot mah 2013-12-04T16:17:06Z biological_process owl:Class
GO:0034613 biolink:NamedThing cellular protein localization Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. got7fsn_ti cellular protein localisation|channel localizer activity GO:0016249 biological_process owl:Class
GO:0008406 biolink:NamedThing gonad development The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones. got7fsn_ti gonadogenesis biological_process owl:Class
GO:0048608 biolink:NamedThing reproductive structure development The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures. got7fsn_ti biological_process owl:Class
GO:0004129 biolink:NamedThing cytochrome-c oxidase activity Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. got7fsn_ti ba3-type cytochrome c oxidase|cbb3-type cytochrome c oxidase|cytochrome aa3 activity|cytochrome c oxidase activity|Warburg's respiratory enzyme activity|complex IV (mitochondrial electron transport) activity|caa3-type cytochrome c oxidase|cytochrome oxidase activity|aa3-type cytochrome c oxidase|indophenolase|indophenol oxidase|cytochrome a3 activity https://github.com/geneontology/go-ontology/issues/21275|https://github.com/geneontology/go-ontology/issues/20924 The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. RHEA:11436|MetaCyc:CYTOCHROME-C-OXIDASE-RXN|Reactome:R-HSA-163214|EC:7.1.1.9 molecular_function owl:Class
GO:0015453 biolink:NamedThing oxidoreduction-driven active transmembrane transporter activity Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. got7fsn_ti oxidoreduction-driven transporter TC:3.D molecular_function owl:Class
GO:0017178 biolink:NamedThing diphthine-ammonia ligase activity Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate. got7fsn_ti diphthamide synthetase activity|diphthine:ammonia ligase (ADP-forming)|diphthamide synthase activity RHEA:19753|KEGG_REACTION:R03613|Reactome:R-HSA-5358475|EC:6.3.1.14|MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN molecular_function owl:Class
GO:0016880 biolink:NamedThing acid-ammonia (or amide) ligase activity Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti amide synthase activity EC:6.3.1.- molecular_function owl:Class
GO:1901362 biolink:NamedThing organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic cyclic compound. got7fsn_ti organic cyclic compound anabolism|organic cyclic compound biosynthesis|organic cyclic compound formation|organic cyclic compound synthesis bf 2012-09-14T09:05:22Z biological_process owl:Class
GO:1901576 biolink:NamedThing organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. got7fsn_ti organic molecular entity biosynthetic process|organic substance synthesis|organic substance biosynthesis|organic molecular entity biosynthesis|organic substance formation|organic molecular entity anabolism|organic molecular entity formation|organic molecular entity synthesis|organic substance anabolism pr 2012-11-05T11:04:40Z biological_process owl:Class
GO:0090693 biolink:NamedThing plant organ senescence The process that occurs in a plant organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. got7fsn_ti tb 2016-08-24T10:50:29Z biological_process owl:Class
GO:0007568 biolink:NamedThing aging A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). got7fsn_ti ageing GO:0016280 Wikipedia:Aging biological_process owl:Class
GO:0061634 biolink:NamedThing alpha-D-xyloside xylohydrolase Catalysis of the hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose. got7fsn_ti alpha-xylosidase dph 2014-07-28T08:12:39Z EC:3.2.1.177 molecular_function owl:Class
GO:0003403 biolink:NamedThing optic vesicle formation The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. got7fsn_ti dph 2009-12-21T01:42:37Z biological_process owl:Class
GO:0021508 biolink:NamedThing floor plate formation The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage. got7fsn_ti biological_process owl:Class
GO:0033806 biolink:NamedThing fluorothreonine transaldolase activity Catalysis of the reaction: L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine. got7fsn_ti fluoroacetaldehyde:L-threonine aldehydetransferase activity RHEA:11748|EC:2.2.1.8 molecular_function owl:Class
GO:0051139 biolink:NamedThing metal ion:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). got7fsn_ti metal ion:hydrogen antiporter activity Reactome:R-HSA-435171 molecular_function owl:Class
GO:0015299 biolink:NamedThing solute:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). got7fsn_ti solute:hydrogen antiporter activity|L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity Reactome:R-HSA-5625574|Reactome:R-HSA-434650|Reactome:R-HSA-597628 molecular_function owl:Class
GO:0071907 biolink:NamedThing determination of digestive tract left/right asymmetry Determination of the asymmetric location of various parts of the digestive tract with respect to the left and right halves of the organism. The digestive tract is the anatomical structure through which food passes and is processed. got7fsn_ti determination of gut left/right asymmetry|determination of left/right asymmetry of the digestive tract mah 2010-09-22T10:14:29Z biological_process owl:Class
GO:0007368 biolink:NamedThing determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. got7fsn_ti determination of left/right asymmetry biological_process owl:Class
GO:0072537 biolink:NamedThing fibroblast activation A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti mah 2011-01-14T04:35:08Z biological_process owl:Class
GO:0001775 biolink:NamedThing cell activation A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti biological_process owl:Class
GO:0061346 biolink:NamedThing planar cell polarity pathway involved in heart morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart. got7fsn_ti dph 2010-09-30T12:47:24Z biological_process owl:Class
GO:0061341 biolink:NamedThing non-canonical Wnt signaling pathway involved in heart development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to the progression of the heart over time. got7fsn_ti non-canonical Wnt receptor signaling pathway involved in heart development|non-canonical Wnt receptor signalling pathway involved in heart development|non-canonical Wnt-activated signaling pathway involved in heart development dph 2010-09-29T11:27:34Z biological_process owl:Class
GO:0005170 biolink:NamedThing neurotrophin TRKC receptor binding Binding to a neurotrophin TRKC receptor. got7fsn_ti neurotrophin TRKC receptor ligand molecular_function owl:Class
GO:0005167 biolink:NamedThing neurotrophin TRK receptor binding Binding to a neurotrophin TRK receptor. got7fsn_ti neurotrophin TRK receptor ligand molecular_function owl:Class
GO:0102790 biolink:NamedThing cyanidin 5,3-O-glycosyltransferase activity Catalysis of the reaction: cyanidin 5-O-beta-D-glucoside + UDP-alpha-D-glucose = cyanin betaine + UDP. got7fsn_ti MetaCyc:RXN-8006 molecular_function owl:Class
GO:1903513 biolink:NamedThing endoplasmic reticulum to cytosol transport The directed movement of substances from endoplasmic reticulum to cytosol. got7fsn_ti ER to cytosol transport rl 2014-10-02T11:24:34Z biological_process owl:Class
GO:0046907 biolink:NamedThing intracellular transport The directed movement of substances within a cell. got7fsn_ti single-organism intracellular transport|single organism intracellular transport jl 2013-12-18T14:04:50Z GO:1902582 biological_process owl:Class
GO:0102990 biolink:NamedThing 5-n-alk(en)ylresorcinol O-methyltransferase activity Catalysis of the reaction: 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + S-adenosyl-L-methionine <=> H+ + 5-(pentadeca-8,11,14-trien-1-yl)resorcinol monomethyl ether + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:26325|MetaCyc:RXN-9619 molecular_function owl:Class
GO:0035755 biolink:NamedThing cardiolipin hydrolase activity Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA). got7fsn_ti https://github.com/geneontology/go-ontology/issues/8492|https://github.com/geneontology/go-ontology/issues/21230 bf 2011-03-24T10:14:05Z Reactome:R-HSA-8954398 molecular_function owl:Class
GO:0004620 biolink:NamedThing phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid. got7fsn_ti Reactome:R-HSA-6792445|EC:3.1.1.-|Reactome:R-HSA-6786650 molecular_function owl:Class
GO:0036017 biolink:NamedThing response to erythropoietin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis. got7fsn_ti bf 2011-10-12T10:11:04Z biological_process owl:Class
GO:0006620 biolink:NamedThing posttranslational protein targeting to endoplasmic reticulum membrane The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane. got7fsn_ti posttranslational protein targeting to ER membrane|posttranslational endoplasmic reticulum membrane targeting|posttranslational endoplasmic reticulum protein-membrane targeting|SRP-independent endoplasmic reticulum protein-membrane targeting|posttranslational protein endoplasmic reticulum membrane targeting biological_process owl:Class
GO:0045047 biolink:NamedThing protein targeting to ER The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane. got7fsn_ti protein-endoplasmic reticulum targeting|protein-ER targeting|protein targeting to endoplasmic reticulum biological_process owl:Class
GO:0035577 biolink:NamedThing azurophil granule membrane The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. got7fsn_ti primary granule membrane bf 2010-10-05T01:29:10Z cellular_component owl:Class
GO:0030667 biolink:NamedThing secretory granule membrane The lipid bilayer surrounding a secretory granule. got7fsn_ti secretory vesicle membrane cellular_component owl:Class
GO:0030956 biolink:NamedThing glutamyl-tRNA(Gln) amidotransferase complex A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms. got7fsn_ti AdT|GatFAB|GatCAB Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'. cellular_component owl:Class
GO:0140535 biolink:NamedThing intracellular protein-containing complex A protein-containing complex located intracellularly. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19952 pg 2020-10-28T14:40:16Z cellular_component owl:Class
GO:0030896 biolink:NamedThing checkpoint clamp complex Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage. got7fsn_ti Rad9-Hus1-Rad1 (9-1-1) clamp complex|CCC Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p. cellular_component owl:Class
GO:0046888 biolink:NamedThing negative regulation of hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell. got7fsn_ti inhibition of hormone secretion|down-regulation of hormone secretion|downregulation of hormone secretion|down regulation of hormone secretion biological_process owl:Class
GO:0023057 biolink:NamedThing negative regulation of signaling Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. got7fsn_ti negative regulation of signaling process|negative regulation of signalling process 2010-02-16T09:30:50Z biological_process owl:Class
GO:0075289 biolink:NamedThing aplanospore formation The process in which a nonmotile, asexual spore is formed within a cell in certain algae and fungi (commonly in the Phycomycetes), the wall of aplanospore is distinct from that of the parent cell. got7fsn_ti biological_process owl:Class
GO:0034300 biolink:NamedThing sporangiospore formation The process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm. got7fsn_ti biological_process owl:Class
GO:0035545 biolink:NamedThing determination of left/right asymmetry in nervous system The establishment of the nervous system with respect to the left and right halves. got7fsn_ti bf 2010-05-11T01:53:33Z biological_process owl:Class
GO:0070854 biolink:NamedThing myosin VI heavy chain binding Binding to a heavy chain of a myosin VI complex. got7fsn_ti mah 2009-08-13T01:44:05Z molecular_function owl:Class
GO:0070853 biolink:NamedThing myosin VI binding Binding to a class VI myosin. The myosin VI heavy chain has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain, a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. got7fsn_ti mah 2009-08-13T01:28:36Z molecular_function owl:Class
GO:0016560 biolink:NamedThing protein import into peroxisome matrix, docking The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane. got7fsn_ti protein docking during protein import into peroxisome matrix|protein transport into peroxisome matrix, docking|protein docking during protein transport into peroxisome matrix|peroxisome matrix protein import, docking|peroxisome receptor docking|protein docking during peroxisome matrix protein import biological_process owl:Class
GO:0008104 biolink:NamedThing protein localization Any process in which a protein is transported to, or maintained in, a specific location. got7fsn_ti asymmetric protein localisation|establishment and maintenance of asymmetric protein localization|protein localisation|asymmetric protein localization|establishment and maintenance of protein localization GO:0008105 biological_process owl:Class
GO:0030125 biolink:NamedThing clathrin vesicle coat A clathrin coat found on a vesicle. got7fsn_ti cellular_component owl:Class
GO:0030118 biolink:NamedThing clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. got7fsn_ti clathrin cage GO:0016190 Wikipedia:Clathrin|NIF_Subcellular:sao879919129 cellular_component owl:Class
GO:0044845 biolink:NamedThing chain elongation of O-linked mannose residue Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules. got7fsn_ti Example annotations to this term include the S. cerevisiae alpha1,2-mannosyltransferases ScKre2p, ScKtr1p and ScKtr3pof the KTR family. jl 2014-05-08T15:56:39Z biological_process owl:Class
GO:0035268 biolink:NamedThing protein mannosylation The addition of a mannose residue to a protein acceptor molecule. got7fsn_ti protein amino acid mannosylation biological_process owl:Class
GO:0004632 biolink:NamedThing phosphopantothenate--cysteine ligase activity Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives. got7fsn_ti (R)-4'-phosphopantothenate:L-cysteine ligase activity|phosphopantothenate-cysteine ligase activity|phosphopantothenoylcysteine synthetase activity Reactome:R-HSA-196753|RHEA:19397|EC:6.3.2.5|MetaCyc:P-PANTOCYSLIG-RXN molecular_function owl:Class
GO:0016881 biolink:NamedThing acid-amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti peptide synthase activity EC:6.3.2.- molecular_function owl:Class
GO:0097143 biolink:NamedThing PUMA-BCL-xl complex A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:44:10Z cellular_component owl:Class
GO:0097136 biolink:NamedThing Bcl-2 family protein complex A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. got7fsn_ti pr 2011-08-02T01:34:19Z cellular_component owl:Class
GO:0033131 biolink:NamedThing regulation of glucokinase activity Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule. got7fsn_ti glucokinase regulator biological_process owl:Class
GO:0010906 biolink:NamedThing regulation of glucose metabolic process Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. got7fsn_ti regulation of glucose metabolism biological_process owl:Class
GO:0047435 biolink:NamedThing 5-guanidino-2-oxopentanoate decarboxylase activity Catalysis of the reaction: 5-guanidino-2-oxopentanoate + H(+) = 4-guanidinobutanal + CO(2). got7fsn_ti 2-oxo-5-guanidinopentanoate carboxy-lyase (4-guanidinobutanal-forming)|2-oxo-5-guanidinopentanoate decarboxylase activity|alpha-ketoarginine decarboxylase activity|2-oxo-5-guanidinovalerate alpha-ketoarginine decarboxylase activity|2-oxo-5-guanidinopentanoate carboxy-lyase activity MetaCyc:4.1.1.75-RXN|KEGG_REACTION:R03178|RHEA:11340|EC:4.1.1.75 molecular_function owl:Class
GO:0018519 biolink:NamedThing cis-dihydroethylcatechol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH. got7fsn_ti cis-ethylbenzene glycol dehydrogenase activity|cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity MetaCyc:1.3.1.66-RXN|RHEA:18101|UM-BBD_reactionID:r0309|EC:1.3.1.66|KEGG_REACTION:R05313 molecular_function owl:Class
GO:0097057 biolink:NamedThing TRAF2-GSTP1 complex A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses. got7fsn_ti pr 2011-05-26T10:35:45Z cellular_component owl:Class
GO:0052905 biolink:NamedThing tRNA (guanine(9)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine. got7fsn_ti tRNA(m(1)G(9)/m(1)A(9))Mtase activity|tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity|tRNA m(1)G(9) Mtase activity|tRNA (guanine-N(1)-)-methyltransferase activity|tRNA m(1)G(9)-methyltransferase activity EC:2.1.1.221|RHEA:43156|MetaCyc:RXN-12459 molecular_function owl:Class
GO:0009019 biolink:NamedThing tRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine. got7fsn_ti transfer ribonucleate guanine 1-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity|tRNA guanine 1-methyltransferase activity Reactome:R-HSA-6782859|Reactome:R-HSA-6786621|Reactome:R-HSA-6787591 molecular_function owl:Class
GO:0071363 biolink:NamedThing cellular response to growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. got7fsn_ti mah 2009-12-11T03:05:07Z biological_process owl:Class
GO:0046467 biolink:NamedThing membrane lipid biosynthetic process The chemical reactions and pathways resulting in the formation of membrane lipids, any lipid found in or associated with a biological membrane. got7fsn_ti membrane lipid synthesis|membrane lipid biosynthesis|membrane lipid anabolism|membrane lipid formation biological_process owl:Class
GO:0048800 biolink:NamedThing antennal morphogenesis The process in which the anatomical structures of the antenna are generated and organized. got7fsn_ti biological_process owl:Class
GO:0001555 biolink:NamedThing oocyte growth The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. got7fsn_ti biological_process owl:Class
GO:0051723 biolink:NamedThing protein methylesterase activity Catalysis of the reaction: protein amino acid methyl ester + H2O = protein amino acid + methanol. got7fsn_ti protein carboxylic ester hydrolase activity|protein methyl-esterase activity|protein carboxyl methylesterase activity|PME activity Reactome:R-HSA-5367022 molecular_function owl:Class
GO:0072764 biolink:NamedThing cellular response to reversine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus. got7fsn_ti mah 2012-11-09T11:52:22Z biological_process owl:Class
GO:0071415 biolink:NamedThing cellular response to purine-containing compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. got7fsn_ti cellular response to purine mah 2009-12-14T03:12:20Z biological_process owl:Class
GO:0102510 biolink:NamedThing pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + vanillate + H+. got7fsn_ti MetaCyc:RXN-14439|EC:2.4.1.299 molecular_function owl:Class
GO:0072756 biolink:NamedThing cellular response to paraquat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus. got7fsn_ti mah 2012-11-07T12:08:59Z biological_process owl:Class
GO:0071310 biolink:NamedThing cellular response to organic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. got7fsn_ti mah 2009-12-10T04:46:04Z biological_process owl:Class
GO:0003886 biolink:NamedThing DNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. got7fsn_ti deoxyribonucleic acid (cytosine-5-)-methyltransferase activity|type II DNA methylase activity|DNA cytosine methylase activity|DNA cytosine C5 methylase activity|methylphosphotriester-DNA methyltransferase activity|cytosine DNA methylase activity|DNA-cytosine 5-methylase activity|deoxyribonucleic (cytosine-5-)-methyltransferase activity|deoxyribonucleic methylase activity|cytosine DNA methyltransferase activity|restriction-modification system activity|cytosine-specific DNA methyltransferase activity|site-specific DNA-methyltransferase (cytosine-specific) activity|modification methylase activity|DNA 5-cytosine methylase activity|DNA cytosine C(5) methylase activity|cytosine 5-methyltransferase activity|DNA-cytosine methyltransferase activity|S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). GO:0008326 EC:2.1.1.37|MetaCyc:2.1.1.73-RXN|RHEA:13681 molecular_function owl:Class
GO:0009008 biolink:NamedThing DNA-methyltransferase activity Catalysis of the transfer of a methyl group to a DNA molecule. got7fsn_ti DNA transmethylase activity|deoxyribonucleate methyltransferase activity|deoxyribonucleic acid methylase activity|DNA methylase|Type II DNA methylase|deoxyribonucleate methylase activity|deoxyribonucleic acid methyltransferase activity|deoxyribonucleic acid modification methylase activity|DNA methyltransferase activity Reactome:R-HSA-5227490 molecular_function owl:Class
GO:1902441 biolink:NamedThing protein localization to meiotic spindle pole body A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body. got7fsn_ti protein localisation in meiotic spindle pole body|protein localization in meiotic spindle pole body|protein localisation to meiotic spindle pole body|protein location to meiotic spindle pole body|establishment of protein localization to meiotic spindle pole body mah 2013-10-10T14:45:04Z GO:1990945|GO:1990954 biological_process owl:Class
GO:0033408 biolink:NamedThing UCG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCG codon. got7fsn_ti TCG codon-amino acid adaptor activity|serine tRNA Note that in the standard genetic code, TCG codes for serine. molecular_function owl:Class
GO:0072105 biolink:NamedThing ureteric peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, impelling the contents onwards. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder. got7fsn_ti mah 2010-02-10T03:07:54Z biological_process owl:Class
GO:0030432 biolink:NamedThing peristalsis A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards. got7fsn_ti Wikipedia:Peristalsis biological_process owl:Class
GO:0030686 biolink:NamedThing 90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. got7fsn_ti cellular_component owl:Class
GO:0030684 biolink:NamedThing preribosome Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis. got7fsn_ti cellular_component owl:Class
GO:0031726 biolink:NamedThing CCR1 chemokine receptor binding Binding to a CCR1 chemokine receptor. got7fsn_ti macrophage inflammatory protein-1 alpha receptor binding|CCR1 chemokine receptor ligand molecular_function owl:Class
GO:0048020 biolink:NamedThing CCR chemokine receptor binding Binding to a CCR chemokine receptor. got7fsn_ti beta chemokine receptor ligand|CCR chemokine receptor ligand|beta chemokine receptor binding molecular_function owl:Class
GO:0030870 biolink:NamedThing Mre11 complex Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins. got7fsn_ti RAD50-MRE11-NBN complex|Rad50-Rad32-Nbs1 complex|MRN complex|Rad50 complex|RMX complex|MRX complex cellular_component owl:Class
GO:0046957 biolink:NamedThing negative phototaxis The directed movement of a cell or organism away from a source of light. got7fsn_ti negative phototactic behavior|negative taxis in response to light|negative phototactic behaviour GO:0046955 biological_process owl:Class
GO:0052129 biolink:NamedThing negative energy taxis The directed movement of a motile cell or organism towards a lower level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. got7fsn_ti biological_process owl:Class
GO:0033974 biolink:NamedThing nucleoside phosphoacylhydrolase activity Catalysis of the hydrolysis of mixed phospho-anhydride bonds. got7fsn_ti nucleoside-5'-phosphoacylate acylhydrolase activity EC:3.6.1.24|MetaCyc:3.6.1.24-RXN molecular_function owl:Class
GO:0016818 biolink:NamedThing hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. got7fsn_ti EC:3.6.1.- molecular_function owl:Class
GO:0033872 biolink:NamedThing [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. got7fsn_ti heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A activity|glucosaminyl 3-O-sulfotransferase 3a, 3b activity|3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity|3-OST-3|heparin-glucosamine 3-sulfotransferase 3 activity|glucosaminyl 3-O-sulfotransferase 3 activity|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3 activity|isoform/isozyme 3a and 3b (3-OST-3A, 3-OST-3B, HS3ST3A, HS3ST3B) MetaCyc:2.8.2.30-RXN|EC:2.8.2.30 molecular_function owl:Class
GO:0034483 biolink:NamedThing heparan sulfate sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. got7fsn_ti molecular_function owl:Class
GO:0035768 biolink:NamedThing endothelial cell chemotaxis to fibroblast growth factor The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF). got7fsn_ti bf 2011-03-31T04:32:17Z biological_process owl:Class
GO:0035767 biolink:NamedThing endothelial cell chemotaxis The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti bf 2011-03-31T04:31:37Z biological_process owl:Class
GO:0042037 biolink:NamedThing peptidyl-histidine methylation, to form pros-methylhistidine The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). got7fsn_ti peptidyl-histidine pros-methylation GO:0042260 RESID:AA0073 biological_process owl:Class
GO:0018021 biolink:NamedThing peptidyl-histidine methylation The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine). got7fsn_ti RESID:AA0073|RESID:AA0317 biological_process owl:Class
GO:0043098 biolink:NamedThing purine deoxyribonucleoside salvage Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0046123 biolink:NamedThing purine deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine deoxyribonucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). got7fsn_ti purine deoxyribonucleoside anabolism|purine deoxyribonucleoside formation|purine deoxyribonucleoside biosynthesis|purine deoxyribonucleoside synthesis biological_process owl:Class
GO:0009649 biolink:NamedThing entrainment of circadian clock The synchronization of a circadian rhythm to environmental time cues such as light. got7fsn_ti regulation of circadian rhythm phase biological_process owl:Class
GO:0018964 biolink:NamedThing propylene metabolic process The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals. got7fsn_ti propylene metabolism UM-BBD_pathwayID:pro biological_process owl:Class
GO:0006805 biolink:NamedThing xenobiotic metabolic process The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti drug metabolism|xenobiotic metabolism|drug metabolic process https://github.com/geneontology/go-ontology/issues/19460 GO:0017144 Wikipedia:Xenobiotic_metabolism|Wikipedia:Drug_metabolism biological_process owl:Class
GO:0045462 biolink:NamedThing trichothecene 3-O-acetyltransferase activity Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis. got7fsn_ti molecular_function owl:Class
GO:0040024 biolink:NamedThing dauer larval development The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. got7fsn_ti biological_process owl:Class
GO:0002119 biolink:NamedThing nematode larval development The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. got7fsn_ti biological_process owl:Class
GO:0008967 biolink:NamedThing phosphoglycolate phosphatase activity Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate. got7fsn_ti phosphoglycolate hydrolase activity|P-glycolate phosphatase activity|phosphoglycollate phosphatase activity|2-phosphoglycolate phosphohydrolase activity|2-phosphoglycolate phosphatase activity RHEA:14369|EC:3.1.3.18|KEGG_REACTION:R01334|MetaCyc:GPH-RXN molecular_function owl:Class
GO:0016791 biolink:NamedThing phosphatase activity Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. got7fsn_ti PNPPase activity|nitrophenyl phosphatase activity|para-nitrophenyl phosphatase activity|phosphatase|p-nitrophenylphosphate phosphohydrolase activity|phosphoric monoester hydrolase activity|4-nitrophenylphosphate phosphohydrolase activity|ecto-p-nitrophenyl phosphatase activity|NPPase activity|p-nitrophenylphosphatase activity|K-pNPPase activity|4-nitrophenylphosphatase activity GO:0003869|GO:0016302 Reactome:R-HSA-9636457|Reactome:R-HSA-4419986|MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN|EC:3.1.3.- molecular_function owl:Class
GO:0031837 biolink:NamedThing substance K receptor binding Binding to a substance K receptor. got7fsn_ti substance K receptor ligand|neurokinin-A receptor binding molecular_function owl:Class
GO:0031834 biolink:NamedThing neurokinin receptor binding Binding to a neurokinin receptor. got7fsn_ti neurokinin receptor ligand molecular_function owl:Class
GO:0071047 biolink:NamedThing polyadenylation-dependent mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. got7fsn_ti poly(A)-dependent mRNA catabolic process https://github.com/geneontology/go-ontology/issues/20568 krc 2009-08-07T09:57:56Z biological_process owl:Class
GO:0043633 biolink:NamedThing polyadenylation-dependent RNA catabolic process The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA. got7fsn_ti polyadenylation-dependent RNA catabolic process biological_process owl:Class
GO:0009535 biolink:NamedThing chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. got7fsn_ti cellular_component owl:Class
GO:0055035 biolink:NamedThing plastid thylakoid membrane The lipid bilayer membrane of any thylakoid within a plastid. got7fsn_ti cellular_component owl:Class
GO:0008707 biolink:NamedThing 4-phytase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate. got7fsn_ti phytate 6-phosphatase activity|6-phytase activity|6-phytase (name based on 1L-numbering system and not 1D-numbering)|myo-inositol-hexakisphosphate 6-phosphohydrolase activity|phytase activity MetaCyc:6-PHYT-RXN|EC:3.1.3.26|RHEA:20960 molecular_function owl:Class
GO:0004447 biolink:NamedThing iodide peroxidase activity Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O. got7fsn_ti thyroperoxidase activity|iodinase activity|TPO activity|thyroid peroxidase activity https://github.com/geneontology/go-ontology/issues/21027 MetaCyc:IODIDE-PEROXIDASE-RXN|EC:1.11.1.8 molecular_function owl:Class
GO:0004601 biolink:NamedThing peroxidase activity Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O. got7fsn_ti horseradish peroxidase (HRP)|peroxidase reaction|verdoperoxidase|protoheme peroxidase|MPO|secretory plant peroxidase activity|oxyperoxidase activity|heme peroxidase|guaiacol peroxidase|thiocyanate peroxidase|myeloperoxidase activity|lactoperoxidase activity|donor:hydrogen-peroxide oxidoreductase activity|pyrocatechol peroxidase|japanese radish peroxidase|scopoletin peroxidase|bacterial catalase-peroxidase activity|extensin peroxidase|eosinophil peroxidase activity GO:0016685|GO:0016686|GO:0016687|GO:0016693 Reactome:R-HSA-6789126|Reactome:R-HSA-209840|EC:1.11.1.-|Reactome:R-HSA-140359|Reactome:R-HSA-350901|Reactome:R-HSA-5631885|Reactome:R-HSA-2559639|Reactome:R-HSA-209925|KEGG_REACTION:R03532|Reactome:R-HSA-209973|Reactome:R-HSA-209815|Reactome:R-HSA-1222346|Reactome:R-HSA-3341296|Reactome:R-HSA-8933635|Reactome:R-HSA-6789031|MetaCyc:PEROXID-RXN|Reactome:R-HSA-8855490|Reactome:R-HSA-2309773 molecular_function owl:Class
GO:0071464 biolink:NamedThing cellular response to hydrostatic pressure Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. got7fsn_ti cellular response to biomechanical stress|cellular response to static fluid pressure mah 2009-12-18T11:34:07Z biological_process owl:Class
GO:0051599 biolink:NamedThing response to hydrostatic pressure Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. got7fsn_ti response to biomechanical stress|response to static fluid pressure biological_process owl:Class
GO:0009036 biolink:NamedThing type II site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site. got7fsn_ti type II restriction enzyme activity EC:3.1.21.4|MetaCyc:3.1.21.4-RXN molecular_function owl:Class
GO:0015666 biolink:NamedThing restriction endodeoxyribonuclease activity Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks. got7fsn_ti restriction enzyme activity|restriction endonuclease activity molecular_function owl:Class
GO:0097191 biolink:NamedThing extrinsic apoptotic signaling pathway A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. got7fsn_ti extrinsic apoptosis|extrinsic apoptotic pathway|extrinsic apoptotic signalling pathway|extrinsic apoptotic signaling pathway in presence of ligand|death receptor-mediated apoptosis Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer. pr 2011-11-23T09:34:28Z biological_process owl:Class
GO:0007166 biolink:NamedThing cell surface receptor signaling pathway A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti cell surface receptor linked signaling pathway|cell surface receptor linked signalling pathway|cell surface receptor linked signal transduction biological_process owl:Class
GO:0046619 biolink:NamedThing lens placode formation involved in camera-type eye formation Establishment and formation of the optic placode, paired ectodermal placodes that become invaginated to form the embryonic lens vesicles. got7fsn_ti optic placode formation involved in camera-style eye|optic placode formation in camera-type eye|optic placode formation involved in camera-type eye formation biological_process owl:Class
GO:0001743 biolink:NamedThing lens placode formation The initial developmental process that will lead to the formation of an eye. got7fsn_ti optic placode formation biological_process owl:Class
GO:0030520 biolink:NamedThing intracellular estrogen receptor signaling pathway Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription). got7fsn_ti estrogen receptor signaling pathway|estrogen receptor signalling pathway biological_process owl:Class
GO:0030518 biolink:NamedThing intracellular steroid hormone receptor signaling pathway A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands. got7fsn_ti steroid hormone receptor signalling pathway|steroid hormone receptor signaling pathway biological_process owl:Class
GO:0031635 biolink:NamedThing adenylate cyclase-inhibiting opioid receptor signaling pathway The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti inhibition of adenylate cyclase activity by opioid receptor signalling pathway|opioid receptor, adenylate cyclase inhibiting pathway|inhibition of adenylate cyclase activity by opioid receptor signaling pathway biological_process owl:Class
GO:0007193 biolink:NamedThing adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti G protein signaling, adenylyl cyclase inhibiting pathway|GPCR signaling pathway via inhibition of adenylate cyclase activity|G-protein signaling, adenylyl cyclase inhibiting pathway|G protein signalling, adenylate cyclase inhibiting pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|G-protein signalling, adenylate cyclase inhibiting pathway|G-protein signalling, adenylyl cyclase inhibiting pathway|G protein signaling, adenylate cyclase inhibiting pathway|adenylate cyclase-inhibiting GPCR signaling pathway|G-protein signaling, adenylate cyclase inhibiting pathway|G protein signalling, adenylyl cyclase inhibiting pathway This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition. biological_process owl:Class
GO:0045476 biolink:NamedThing nurse cell apoptotic process Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process. got7fsn_ti apoptosis of nurse cells|nurse cell apoptosis|programmed cell death of nurse cells by apoptosis|invertebrate nurse cell apoptosis|nurse cell programmed cell death by apoptosis biological_process owl:Class
GO:0006915 biolink:NamedThing apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. got7fsn_ti apoptosis activator activity|commitment to apoptosis|apoptotic program|cellular suicide|programmed cell death by apoptosis|cell suicide|caspase-dependent programmed cell death|apoptotic cell death|type I programmed cell death|apoptotic programmed cell death|signaling (initiator) caspase activity|apoptosis signaling|induction of apoptosis|apoptosis|activation of apoptosis|induction of apoptosis by p53 GO:0006917|GO:0008632 Wikipedia:Apoptosis biological_process owl:Class
GO:0046753 biolink:NamedThing non-lytic viral release The exit of a viral particle from a cell that does not involve cell lysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18852 biological_process owl:Class
GO:0019076 biolink:NamedThing viral release from host cell The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane. got7fsn_ti viral shedding|viral exit|release of virus from host|virus exit from host cell|viral release VZ:1076 biological_process owl:Class
GO:0018360 biolink:NamedThing protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine. got7fsn_ti protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine GO:0018384 RESID:AA0271 biological_process owl:Class
GO:0046559 biolink:NamedThing alpha-glucuronidase activity Catalysis of the reaction: an alpha-D-glucuronoside + H2O = an alcohol + D-glucuronate. got7fsn_ti alpha-glucosiduronase activity|alpha-D-glucosiduronate glucuronohydrolase activity RHEA:20005|EC:3.2.1.139|MetaCyc:3.2.1.139-RXN molecular_function owl:Class
GO:0018116 biolink:NamedThing peptidyl-lysine adenylylation The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine. got7fsn_ti peptidyl-lysine adenylation RESID:AA0227 biological_process owl:Class
GO:0018205 biolink:NamedThing peptidyl-lysine modification The modification of peptidyl-lysine. got7fsn_ti biological_process owl:Class
GO:0035469 biolink:NamedThing determination of pancreatic left/right asymmetry Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism. got7fsn_ti bf 2010-04-22T10:47:15Z biological_process owl:Class
GO:0106029 biolink:NamedThing tRNA pseudouridine synthase activity Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. got7fsn_ti tRNA pseudouridine(32) synthase|tRNA pseudouridine(65) synthase|transfer ribonucleate pseudouridine synthetase activity|tRNA pseudouridine(13) synthase|tRNA-pseudouridine synthase activity|tRNA pseudouridine(31) synthase|tRNA pseudouridine(38-40) synthase|tRNA pseudouridylate synthase I activity|tRNA-pseudouridine synthase I activity|tRNA-uridine isomerase activity|tRNA pseudouridine(55) synthase|tRNA pseudouridine(38/39) synthase|tRNA-uridine uracilmutase activity|transfer RNA pseudouridine synthetase activity|Mitochondrial tRNA pseudouridine(27/28) synthase hjd 2017-06-26T17:37:30Z EC:5.4.99.42|EC:5.4.99.26|EC:5.4.99.44|RHEA:22376|MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN|EC:5.4.99.12|EC:5.4.99.45|EC:5.4.99.28|EC:5.4.99.27|EC:5.4.99.25 molecular_function owl:Class
GO:0009982 biolink:NamedThing pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. got7fsn_ti Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. GO:0016439 Reactome:R-HSA-6782381|Reactome:R-HSA-6787566|Reactome:R-HSA-6790905|Reactome:R-HSA-8870289|Reactome:R-HSA-6786583 molecular_function owl:Class
GO:0097374 biolink:NamedThing sensory neuron axon guidance The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses. got7fsn_ti pr 2012-10-01T10:16:22Z biological_process owl:Class
GO:0007411 biolink:NamedThing axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti axon pathfinding|axon chemotaxis|axon growth cone guidance GO:0008040 Wikipedia:Axon_guidance biological_process owl:Class
GO:0001120 biolink:NamedThing protein-DNA complex remodeling The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex. got7fsn_ti krc 2010-12-03T04:17:15Z biological_process owl:Class
GO:0071824 biolink:NamedThing protein-DNA complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex. got7fsn_ti DNA-protein complex subunit organization|protein-DNA complex subunit organisation mah 2010-09-08T10:03:26Z biological_process owl:Class
GO:0018558 biolink:NamedThing 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0049 molecular_function owl:Class
GO:0098648 biolink:NamedThing collagen anchoring fibril A specialised collagen fibril that functions as an anchor, binding to other collagen structures. got7fsn_ti cellular_component owl:Class
GO:0098644 biolink:NamedThing complex of collagen trimers A complex of collagen trimers such as a fibril or collagen network. got7fsn_ti Supramolecular collagen assembly|Supramolecular aggregate of collagen cellular_component owl:Class
GO:0106097 biolink:NamedThing cellular response to ceramide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus. got7fsn_ti hjd 2018-02-12T19:52:55Z biological_process owl:Class
GO:0071396 biolink:NamedThing cellular response to lipid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. got7fsn_ti mah 2009-12-11T04:37:10Z biological_process owl:Class
GO:0003983 biolink:NamedThing UTP:glucose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose. got7fsn_ti uridine diphosphate-D-glucose pyrophosphorylase activity|UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity|uridine diphosphoglucose pyrophosphorylase activity|UDP glucose pyrophosphorylase activity|uridine-diphosphate glucose pyrophosphorylase activity|UDPG pyrophosphorylase activity|UTP-glucose-1-phosphate uridylyltransferase activity|UDPG phosphorylase activity|glucose-1-phosphate uridylyltransferase activity|UDP-glucose diphosphorylase activity|UDP-glucose pyrophosphorylase activity|uridine 5'-diphosphoglucose pyrophosphorylase activity EC:2.7.7.9|Reactome:R-HSA-70286|RHEA:19889|KEGG_REACTION:R00289|MetaCyc:GLUC1PURIDYLTRANS-RXN molecular_function owl:Class
GO:0051748 biolink:NamedThing UTP-monosaccharide-1-phosphate uridylyltransferase activity Catalysis of the reaction: UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide. got7fsn_ti UDP-monosaccharide diphosphorylase activity|USP|PsUSP|UDP-sugar pyrophosphorylase activity|UDP-monosaccharide pyrophosphorylase activity MetaCyc:2.7.7.64-RXN|EC:2.7.7.64|RHEA:13205 molecular_function owl:Class
GO:0009496 biolink:NamedThing plastoquinol--plastocyanin reductase activity Catalysis of the reaction: 2 H(+)[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H(+)[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane. got7fsn_ti cytochrome b6f|plastoquinol-plastocyanin reductase activity|cytochrome b6f complex activity|plastoquinol:oxidized-plastocyanin oxidoreductase activity|plastoquinol/plastocyanin oxidoreductase activity EC:7.1.1.6|KEGG_REACTION:R03817|MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN|RHEA:22148 molecular_function owl:Class
GO:0032195 biolink:NamedThing post-lysosomal vacuole A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis. got7fsn_ti post-lysosome cellular_component owl:Class
GO:0030139 biolink:NamedThing endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting. got7fsn_ti endocytotic vesicle|endocytotic transport vesicle NIF_Subcellular:sao1362520468 cellular_component owl:Class
GO:0008762 biolink:NamedThing UDP-N-acetylmuramate dehydrogenase activity Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. got7fsn_ti uridine diphosphoacetylpyruvoylglucosamine reductase activity|uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity|UDP-N-acetylenolpyruvoylglucosamine reductase activity|MurB reductase|UDP-GlcNAc-enoylpyruvate reductase activity|UDP-N-acetylmuramate:NADP+ oxidoreductase activity|UDP-N-acetylglucosamine-enoylpyruvate reductase activity|uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN|RHEA:12248|EC:1.3.1.98 molecular_function owl:Class
GO:0090253 biolink:NamedThing convergent extension involved in imaginal disc-derived wing morphogenesis The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis. got7fsn_ti tb 2010-01-22T11:40:46Z biological_process owl:Class
GO:0009886 biolink:NamedThing post-embryonic animal morphogenesis The process, occurring after animal embryonic development, by which anatomical structures are generated and organized. got7fsn_ti post-embryonic morphogenesis of an anatomical structure biological_process owl:Class
GO:0046774 biolink:NamedThing suppression by virus of host intracellular interferon activity Any viral process that results in the inhibition of interferon activity within the host cell. got7fsn_ti suppression by virus of intracellular interferon activity in host|negative regulation by virus of intracellular interferon activity biological_process owl:Class
GO:0030683 biolink:NamedThing mitigation of host immune response by virus A process by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti suppression of host extracellular antiviral response by virus|negative regulation by virus of intracellular antiviral response|negative regulation by virus of extracellular antiviral response|evasion by virus of host immune response|evasion or tolerance by virus of host immune response|suppression by virus of host extracellular antiviral response|negative regulation of host intracellular antiviral response by virus|viral inhibition of intracellular antiviral response|mitigation by virus of host immune response|suppression by virus of host intracellular antiviral response|suppression by virus of host immune response|suppression of host intracellular antiviral response by virus|negative regulation of host extracellular antiviral response by virus|inhibition of extracellular antiviral response GO:0019052|GO:0019053 biological_process owl:Class
GO:0044514 biolink:NamedThing envenomation resulting in positive regulation of G protein-coupled receptor activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G protein-coupled receptor activity in of the bitten organism. got7fsn_ti envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism jl 2012-02-26T11:06:15Z biological_process owl:Class
GO:0044513 biolink:NamedThing envenomation resulting in modulation of G protein-coupled receptor activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G protein-coupled receptor activity in of the bitten organism. got7fsn_ti envenomation resulting in modulation of G-protein coupled receptor activity in other organism jl 2012-02-26T11:02:17Z biological_process owl:Class
GO:0032879 biolink:NamedThing regulation of localization Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. got7fsn_ti regulation of localisation biological_process owl:Class
GO:0050789 biolink:NamedThing regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. got7fsn_ti regulation of physiological process GO:0050791 biological_process owl:Class
GO:0046525 biolink:NamedThing xylosylprotein 4-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + O-beta-D-xylosylprotein = UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein. got7fsn_ti UDP-D-galactose:xylose galactosyltransferase activity|UDP-D-galactose:D-xylose galactosyltransferase activity|UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity|uridine diphosphogalactose-xylose galactosyltransferase activity|UDP-galactose:xylose galactosyltransferase activity|galactosyltransferase I activity|UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase activity EC:2.4.1.133|RHEA:15297|MetaCyc:2.4.1.133-RXN|Reactome:R-HSA-1889981|Reactome:R-HSA-3560804 molecular_function owl:Class
GO:0035250 biolink:NamedThing UDP-galactosyltransferase activity Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0140404 biolink:NamedThing effector-mediated modulation of host innate immune response by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppression) of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti effector-triggered modulation of host immune response by symbiont|effector triggered modulation of host immune response by symbiont|effector-dependent modulation of host immune response by symbiont|effector mediated modulation of host immune response by symbiont|effector-mediated modulation of host immunity pg 2019-12-05T11:38:44Z biological_process owl:Class
GO:0140415 biolink:NamedThing effector-mediated modulation of host defenses by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti pg 2020-01-20T16:46:41Z biological_process owl:Class
GO:0120095 biolink:NamedThing vacuole-isolation membrane contact site An organelle membrane contact site formed at the junction of the vacuolar membrane and the isolation membrane or phagophore in response to starvation or other stresses, leading to the formation of the autophagosome. got7fsn_ti vacuole-phagophore contact site|vacuole-IM contact site|VICS krc 2017-09-18T20:01:35Z cellular_component owl:Class
GO:0044232 biolink:NamedThing organelle membrane contact site A zone of apposition between the membranes of an organelle with another membrane, either another membrane of the same organelle, a membrane of another organelle, or the plasma membrane. Membrane contact sites (MCSs) are structured by bridging complexes. They are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions. got7fsn_ti MCS|inter-organelle junction|interorganelle junction https://github.com/geneontology/go-ontology/issues/18994 jl 2010-01-07T03:44:20Z cellular_component owl:Class
GO:0016576 biolink:NamedThing histone dephosphorylation The modification of histones by removal of phosphate groups. got7fsn_ti biological_process owl:Class
GO:0016570 biolink:NamedThing histone modification The covalent alteration of one or more amino acid residues within a histone protein. got7fsn_ti Wikipedia:Histone#Histone_modifications_in_chromatin_regulation biological_process owl:Class
GO:0034783 biolink:NamedThing pivalate-CoA ligase activity Catalysis of the reaction: pivalate + H+ + HSCoA + ATP = pivalyl-CoA + PPi + AMP. got7fsn_ti UM-BBD_reactionID:r1032 molecular_function owl:Class
GO:0016878 biolink:NamedThing acid-thiol ligase activity Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti EC:6.2.1.- molecular_function owl:Class
GO:0046585 biolink:NamedThing enniatin biosynthetic process The chemical reactions and pathways resulting in the formation of enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. got7fsn_ti enniatin biosynthesis|enniatin anabolism|enniatin synthesis|enniatin formation biological_process owl:Class
GO:0017000 biolink:NamedThing antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. got7fsn_ti antibiotic synthesis|antibiotic formation|antibiotic biosynthesis|antibiotic anabolism biological_process owl:Class
GO:0042985 biolink:NamedThing negative regulation of amyloid precursor protein biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. got7fsn_ti inhibition of amyloid precursor protein biosynthetic process|down regulation of amyloid precursor protein biosynthetic process|negative regulation of amyloid precursor protein biosynthesis|downregulation of amyloid precursor protein biosynthetic process|negative regulation of amyloid precursor protein synthesis|down-regulation of amyloid precursor protein biosynthetic process|negative regulation of amyloid precursor protein formation|negative regulation of APP biosynthetic process|negative regulation of amyloid precursor protein anabolism|negative regulation of APP biosynthesis biological_process owl:Class
GO:0010561 biolink:NamedThing negative regulation of glycoprotein biosynthetic process Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. got7fsn_ti biological_process owl:Class
GO:0048640 biolink:NamedThing negative regulation of developmental growth Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth. got7fsn_ti down-regulation of developmental growth|inhibition of developmental growth|downregulation of developmental growth|down regulation of developmental growth biological_process owl:Class
GO:0048638 biolink:NamedThing regulation of developmental growth Any process that modulates the frequency, rate or extent of developmental growth. got7fsn_ti biological_process owl:Class
GO:0051952 biolink:NamedThing regulation of amine transport Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0051049 biolink:NamedThing regulation of transport Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0042066 biolink:NamedThing perineurial glial growth Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons. got7fsn_ti biological_process owl:Class
GO:0042065 biolink:NamedThing glial cell growth Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. got7fsn_ti biological_process owl:Class
GO:0035608 biolink:NamedThing protein deglutamylation The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation. got7fsn_ti protein amino acid deglutamylation bf 2010-11-18T01:04:38Z biological_process owl:Class
GO:0018200 biolink:NamedThing peptidyl-glutamic acid modification The modification of peptidyl-glutamic acid. got7fsn_ti biological_process owl:Class
GO:0042549 biolink:NamedThing photosystem II stabilization The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. got7fsn_ti biological_process owl:Class
GO:0061485 biolink:NamedThing memory T cell proliferation The expansion of a memory T cell population by cell division. got7fsn_ti dph 2012-12-04T09:52:54Z biological_process owl:Class
GO:0042098 biolink:NamedThing T cell proliferation The expansion of a T cell population by cell division. Follows T cell activation. got7fsn_ti T-lymphocyte proliferation|T-cell proliferation|T lymphocyte proliferation GO:0042111 biological_process owl:Class
GO:0002305 biolink:NamedThing CD8-positive, gamma-delta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti CD8-positive, gamma-delta intraepithelial T-cell differentiation|CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation|CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation|CD8-positive, gamma-delta intraepithelial T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0002304 biolink:NamedThing gamma-delta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti gamma-delta intraepithelial T lymphocyte differentiation|gamma-delta intraepithelial T-cell differentiation|gamma-delta intraepithelial T-lymphocyte differentiation|gamma-delta intraepithelial T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0016063 biolink:NamedThing rhodopsin biosynthetic process The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. got7fsn_ti rhodopsin formation|rhodopsin biosynthesis|rhodopsin anabolism|rhodopsin synthesis biological_process owl:Class
GO:0006726 biolink:NamedThing eye pigment biosynthetic process The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. got7fsn_ti eye pigment anabolism|eye pigment synthesis|eye pigment formation|eye pigment biosynthesis biological_process owl:Class
GO:0016860 biolink:NamedThing intramolecular oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. got7fsn_ti intramolecular oxidoreductase activity, other intramolecular oxidoreductases|intramolecular isomerase activity EC:5.3.-.-|Reactome:R-HSA-109998 molecular_function owl:Class
GO:0060096 biolink:NamedThing serotonin secretion, neurotransmission The regulated release of serotonin by a cell, in which released serotonin acts as a neurotransmitter. got7fsn_ti serotonin release, neurotransmission biological_process owl:Class
GO:0001820 biolink:NamedThing serotonin secretion The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells. got7fsn_ti 5-HT secretion|serotonin release|5-hydroxytryptamine secretion biological_process owl:Class
GO:1990775 biolink:NamedThing endothelin production The appearance of a endothelin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. got7fsn_ti EDN2 production|endothelin secretion|endothelin-3 production|EDN1 production|endothelin-2 production|EDN3 production|endothelin-1 secretion sl 2015-06-15T23:13:18Z biological_process owl:Class
GO:0001816 biolink:NamedThing cytokine production The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti cytokine secretion|cytokine biosynthetic process|cytokine metabolic process|interleukin production|interferon production|interleukin secretion|interferon secretion https://github.com/geneontology/go-ontology/issues/19116 Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. GO:0042032|GO:0042107|GO:0042089|GO:0050663 biological_process owl:Class
GO:0009225 biolink:NamedThing nucleotide-sugar metabolic process The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. got7fsn_ti nucleotide-sugar metabolism https://github.com/geneontology/go-ontology/issues/14587 biological_process owl:Class
GO:0055086 biolink:NamedThing nucleobase-containing small molecule metabolic process The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. got7fsn_ti nucleobase, nucleoside and nucleotide metabolic process|nucleobase, nucleoside and nucleotide metabolism biological_process owl:Class
GO:0018165 biolink:NamedThing peptidyl-tyrosine uridylylation The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase. got7fsn_ti RESID:AA0256 biological_process owl:Class
GO:0018212 biolink:NamedThing peptidyl-tyrosine modification The modification of peptidyl-tyrosine. got7fsn_ti biological_process owl:Class
GO:2000147 biolink:NamedThing positive regulation of cell motility Any process that activates or increases the frequency, rate or extent of cell motility. got7fsn_ti positive regulation of movement of a cell|positive regulation of cell movement|positive regulation of cell locomotion mah 2010-10-01T09:41:30Z biological_process owl:Class
GO:2000145 biolink:NamedThing regulation of cell motility Any process that modulates the frequency, rate or extent of cell motility. got7fsn_ti regulation of cell locomotion|regulation of cell movement|regulation of movement of a cell mah 2010-10-01T09:41:21Z biological_process owl:Class
GO:0002164 biolink:NamedThing larval development The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters. got7fsn_ti biological_process owl:Class
GO:0009791 biolink:NamedThing post-embryonic development The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. got7fsn_ti biological_process owl:Class
GO:0140103 biolink:NamedThing catalytic activity, acting on a glycoprotein Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-15T19:27:54Z molecular_function owl:Class
GO:0007458 biolink:NamedThing progression of morphogenetic furrow involved in compound eye morphogenesis The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc. got7fsn_ti progression of morphogenetic furrow during compound eye morphogenesis biological_process owl:Class
GO:0009967 biolink:NamedThing positive regulation of signal transduction Any process that activates or increases the frequency, rate or extent of signal transduction. got7fsn_ti upregulation of signal transduction|up regulation of signal transduction|stimulation of signal transduction|activation of signal transduction|positive regulation of signaling pathway|up-regulation of signal transduction|positive regulation of signalling pathway GO:0035468 biological_process owl:Class
GO:0022008 biolink:NamedThing neurogenesis Generation of cells within the nervous system. got7fsn_ti nervous system cell generation|neural cell differentiation Wikipedia:Neurogenesis biological_process owl:Class
GO:0030154 biolink:NamedThing cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. got7fsn_ti Wikipedia:Cellular_differentiation biological_process owl:Class
GO:0060447 biolink:NamedThing bud outgrowth involved in lung branching The process in which a region of the lung epithelium initiates an outgrowth. got7fsn_ti bud formation involved in lung branching biological_process owl:Class
GO:0060602 biolink:NamedThing branch elongation of an epithelium The growth process in which a branch increases in length from its base to its tip. got7fsn_ti dph 2009-05-14T02:45:44Z biological_process owl:Class
GO:0033692 biolink:NamedThing cellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell. got7fsn_ti cellular glycan biosynthesis|cellular polysaccharide biosynthesis|cellular polysaccharide anabolism|cellular glycan biosynthetic process|cellular polysaccharide synthesis|cellular polysaccharide formation biological_process owl:Class
GO:0034637 biolink:NamedThing cellular carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells. got7fsn_ti biological_process owl:Class
GO:0035878 biolink:NamedThing nail development The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it. got7fsn_ti bf 2011-05-31T02:30:34Z biological_process owl:Class
GO:0034597 biolink:NamedThing phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. got7fsn_ti 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity|inositol polyphosphate 4-phosphatase type II activity|phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase activity MetaCyc:3.1.3.66-RXN|Reactome:R-HSA-6810410|EC:3.1.3.66 molecular_function owl:Class
GO:0034596 biolink:NamedThing phosphatidylinositol phosphate 4-phosphatase activity Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. got7fsn_ti PtdIns4P-phosphatase activity|phosphoinositide 4-phosphatase activity|inositol 4-phosphatase|PI(4)P-phosphatase activity|PI4P-phosphatase activity Reactome:R-HSA-1676133|Reactome:R-HSA-8849969|Reactome:R-HSA-1676124|Reactome:R-HSA-1675988 molecular_function owl:Class
GO:0038131 biolink:NamedThing neuregulin receptor activity Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti NRG2 receptor activity|NRG1 receptor activity|NRG receptor activity Consider also annotating to 'ERBB3 signaling pathway ; GO:0038129' and/or 'ERBB4 signaling pathway ; GO:0038130'. bf 2012-03-30T10:47:11Z molecular_function owl:Class
GO:0004888 biolink:NamedThing transmembrane signaling receptor activity Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. got7fsn_ti transmembrane signalling receptor activity|transmembrane receptor activity This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. GO:0004926|GO:0099600 Reactome:R-HSA-193672 molecular_function owl:Class
GO:0051061 biolink:NamedThing ADP reductase activity Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin. got7fsn_ti ADP reduction MetaCyc:ADPREDUCT-RXN|RHEA:28034 molecular_function owl:Class
GO:0004748 biolink:NamedThing ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. got7fsn_ti 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity|2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'. GO:0016961|GO:0016960|GO:0016959 RHEA:23252|MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN|EC:1.17.4.1|Reactome:R-HSA-111804|Reactome:R-HSA-111751 molecular_function owl:Class
GO:0098833 biolink:NamedThing presynaptic endocytic zone A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity. got7fsn_ti May be identical to periactive zone? cellular_component owl:Class
GO:0110165 biolink:NamedThing cellular anatomical entity A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. got7fsn_ti kmv 2019-08-12T18:01:37Z cellular_component owl:Class
GO:0034754 biolink:NamedThing cellular hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells. got7fsn_ti biological_process owl:Class
GO:0042445 biolink:NamedThing hormone metabolic process The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. got7fsn_ti hormone metabolism biological_process owl:Class
GO:0070977 biolink:NamedThing bone maturation A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. got7fsn_ti mah 2009-10-05T04:35:31Z biological_process owl:Class
GO:0071695 biolink:NamedThing anatomical structure maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state. got7fsn_ti mah 2010-03-02T11:43:38Z biological_process owl:Class
GO:2001151 biolink:NamedThing regulation of renal water transport Any process that modulates the frequency, rate or extent of renal water transport. got7fsn_ti yaf 2011-10-24T11:37:51Z biological_process owl:Class
GO:0071470 biolink:NamedThing cellular response to osmotic stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. got7fsn_ti cellular osmotic stress response|cellular osmotic response mah 2009-12-18T11:45:33Z biological_process owl:Class
GO:0062197 biolink:NamedThing cellular response to chemical stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus indicating the organism is under stress. got7fsn_ti dph 2019-12-10T14:42:03Z biological_process owl:Class
GO:0044790 biolink:NamedThing negative regulation by host of viral release from host cell A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells. got7fsn_ti jl 2013-06-06T10:51:27Z biological_process owl:Class
GO:0044793 biolink:NamedThing negative regulation by host of viral process A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected. got7fsn_ti jl 2013-06-06T11:16:00Z biological_process owl:Class
GO:0046005 biolink:NamedThing positive regulation of circadian sleep/wake cycle, REM sleep Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep. got7fsn_ti stimulation of circadian sleep/wake cycle, REM sleep|activation of circadian sleep/wake cycle, REM sleep|upregulation of circadian sleep/wake cycle, REM sleep|up regulation of circadian sleep/wake cycle, REM sleep|positive regulation of REM sleep|up-regulation of circadian sleep/wake cycle, REM sleep biological_process owl:Class
GO:0045938 biolink:NamedThing positive regulation of circadian sleep/wake cycle, sleep Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. got7fsn_ti up-regulation of circadian sleep/wake cycle, sleep|stimulation of circadian sleep/wake cycle, sleep|upregulation of circadian sleep/wake cycle, sleep|positive regulation of sleep|up regulation of circadian sleep/wake cycle, sleep|activation of circadian sleep/wake cycle, sleep biological_process owl:Class
GO:0061103 biolink:NamedThing carotid body glomus cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a glomus cell of the carotid body. The carotid body is a specialized chemosensory organ that helps respond to hypoxia. got7fsn_ti dph 2010-04-28T10:59:24Z biological_process owl:Class
GO:0061101 biolink:NamedThing neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance. got7fsn_ti dph 2010-04-28T09:42:20Z biological_process owl:Class
GO:0062036 biolink:NamedThing sensory perception of hot stimulus The series of events required for an organism to receive a hot temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. got7fsn_ti dph 2018-04-30T13:50:47Z biological_process owl:Class
GO:0050955 biolink:NamedThing thermoception The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature). got7fsn_ti thermoreception Wikipedia:Thermoception biological_process owl:Class
GO:0043273 biolink:NamedThing CTPase activity Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction. got7fsn_ti cytidine triphosphatase activity|CTPase activity, coupled|single-stranded DNA-dependent CTPase activity https://github.com/geneontology/go-ontology/issues/19078 dph 2015-11-11T13:05:32Z GO:0061747|GO:0061748 molecular_function owl:Class
GO:0017111 biolink:NamedThing nucleoside-triphosphatase activity Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. got7fsn_ti nucleoside triphosphatase activity|nucleoside triphosphate phosphohydrolase activity|nucleoside 5-triphosphatase activity|nucleoside-5-triphosphate phosphohydrolase activity|unspecific diphosphate phosphohydrolase activity|NTPase activity|nucleoside triphosphate hydrolase activity|apyrase activity RHEA:23680|Reactome:R-HSA-8851089|Reactome:R-HSA-8850846|MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN|Reactome:R-HSA-8851110|Reactome:R-HSA-8851494|Reactome:R-HSA-8851538|Reactome:R-HSA-8851234 molecular_function owl:Class
GO:0023021 biolink:NamedThing termination of signal transduction The signaling process in which signal transduction is brought to an end rather than being reversibly modulated. got7fsn_ti Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn. 2010-02-16T09:30:50Z biological_process owl:Class
GO:0009968 biolink:NamedThing negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction. got7fsn_ti inhibition of signal transduction|down regulation of signal transduction|negative regulation of signalling pathway|down-regulation of signal transduction|negative regulation of signaling pathway|downregulation of signal transduction GO:0035467 biological_process owl:Class
GO:0102310 biolink:NamedThing dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate 3-ketoreductase (dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose-forming) activity Catalysis of the reaction: dTDP-4-dehydro-2,6-dideoxy-alpha-D-allose + NAD(P) <=> dTDP-(2R,6S)-6-hydroxy-2-methyl-3-oxo-3,6-dihydro-2H-pyran-4-olate + 2 H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-12940 molecular_function owl:Class
GO:0016726 biolink:NamedThing oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. got7fsn_ti EC:1.17.1.- molecular_function owl:Class
GO:0010646 biolink:NamedThing regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti biological_process owl:Class
GO:0003430 biolink:NamedThing growth plate cartilage chondrocyte growth The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another. got7fsn_ti growth plate cartilage chondrocyte hypertrophy dph 2009-12-22T12:29:19Z biological_process owl:Class
GO:0060560 biolink:NamedThing developmental growth involved in morphogenesis The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape. got7fsn_ti differential growth dph 2009-04-28T08:42:53Z biological_process owl:Class
GO:0051051 biolink:NamedThing negative regulation of transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti down-regulation of transport|down regulation of transport|inhibition of transport|downregulation of transport biological_process owl:Class
GO:0000714 biolink:NamedThing meiotic strand displacement The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis. got7fsn_ti meiotic displacement loop processing|meiotic D-loop processing|meiotic D-loop dissociation|meiotic displacement loop dissociation biological_process owl:Class
GO:0000732 biolink:NamedThing strand displacement The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. got7fsn_ti displacement loop dissociation|D-loop processing|displacement loop processing|D-loop dissociation biological_process owl:Class
GO:0039520 biolink:NamedThing induction by virus of host autophagy Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host. got7fsn_ti positive regulation by virus of host autophagy|activation of host autophagy by virus bf 2011-06-22T04:24:47Z VZ:846 biological_process owl:Class
GO:0039519 biolink:NamedThing modulation by virus of host autophagy Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host. got7fsn_ti regulation by virus of host autophagy bf 2011-06-22T04:19:19Z biological_process owl:Class
GO:0002472 biolink:NamedThing macrophage antigen processing and presentation The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti biological_process owl:Class
GO:0019882 biolink:NamedThing antigen processing and presentation The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti antigen presentation|antigen processing GO:0030333 Wikipedia:Antigen_presentation biological_process owl:Class
GO:0010326 biolink:NamedThing methionine-oxo-acid transaminase activity Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid. got7fsn_ti MetaCyc:RXN-2201 molecular_function owl:Class
GO:0046540 biolink:NamedThing U4/U6 x U5 tri-snRNP complex A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs. got7fsn_ti U4/U6.U5 snRNP complex cellular_component owl:Class
GO:0097526 biolink:NamedThing spliceosomal tri-snRNP complex A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP. got7fsn_ti pr 2013-10-18T15:58:47Z cellular_component owl:Class
GO:0016256 biolink:NamedThing N-glycan processing to lysosome The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome. got7fsn_ti biological_process owl:Class
GO:0006491 biolink:NamedThing N-glycan processing The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking. got7fsn_ti N-linked glycoprotein maturation|glycoprotein trimming involved in glycoprotein maturation GO:0006492 biological_process owl:Class
GO:0005937 biolink:NamedThing mating projection The projection formed by unicellular fungi in response to mating pheromone. got7fsn_ti conjugation tube|shmoo cellular_component owl:Class
GO:0120025 biolink:NamedThing plasma membrane bounded cell projection A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. got7fsn_ti https://github.com/geneontology/go-ontology/issues/13193 krc 2017-03-21T17:26:07Z cellular_component owl:Class
GO:0102599 biolink:NamedThing cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity Catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-beta-amyrin + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-15383 molecular_function owl:Class
GO:0035136 biolink:NamedThing forelimb morphogenesis The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. got7fsn_ti arm morphogenesis GO:0035140 biological_process owl:Class
GO:0047238 biolink:NamedThing glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. got7fsn_ti UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyltransferase II activity|glucuronyl-N-acetylgalactosaminylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity|chondroitin synthase activity|UDP-N-acetyl-D-galactosamine:beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Reactome:R-HSA-1971482|Reactome:R-HSA-9632033|Reactome:R-HSA-1971487|EC:2.4.1.175|Reactome:R-HSA-3595176|MetaCyc:2.4.1.175-RXN molecular_function owl:Class
GO:0008376 biolink:NamedThing acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. got7fsn_ti GalNAc transferase activity Reactome:R-HSA-8931648|Reactome:R-HSA-8855954|Reactome:R-HSA-9605700 molecular_function owl:Class
GO:0016615 biolink:NamedThing malate dehydrogenase activity Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. got7fsn_ti molecular_function owl:Class
GO:0033539 biolink:NamedThing fatty acid beta-oxidation using acyl-CoA dehydrogenase A fatty acid beta-oxidation pathway in which the initial step of each oxidation cycle, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA dehydrogenase; the electrons removed by oxidation pass through the respiratory chain to oxygen and leave H2O as the product. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti MetaCyc:FAO-PWY biological_process owl:Class
GO:0006635 biolink:NamedThing fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti biological_process owl:Class
GO:0033925 biolink:NamedThing mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. got7fsn_ti mannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity|endo-beta-N-acetylglucosaminidase D activity|endo-beta-N-acetylglucosaminidase H activity|glycopeptide-D-mannosyl-N4-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity|endo-beta-N-acetylglucosaminidase L activity|endo-N-acetyl-beta-glucosaminidase activity|endo-beta-N-acetylglucosaminidase activity|endo-N-acetyl-beta-D-glucosaminidase activity|mannosyl-glycoprotein endo-beta-N-acetylglucosamidase activity|endoglycosidase H activity|glycopeptide-D-mannosyl-4-N-(N-acetyl-D-glucosaminyl)2-asparagine 1,4-N-acetyl-beta-glucosaminohydrolase activity|N,N'-diacetylchitobiosyl beta-N-acetylglucosaminidase activity|endo-beta-N-acetylglucosaminidase F activity|endoglycosidase S activity|endo-beta-(1->4)-N-acetylglucosaminidase activity|di-N-acetylchitobiosyl beta-N-acetylglucosaminidase activity|endo-beta-acetylglucosaminidase activity EC:3.2.1.96|MetaCyc:3.2.1.96-RXN|Reactome:R-HSA-8853379 molecular_function owl:Class
GO:0010837 biolink:NamedThing regulation of keratinocyte proliferation Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class
GO:0050678 biolink:NamedThing regulation of epithelial cell proliferation Any process that modulates the frequency, rate or extent of epithelial cell proliferation. got7fsn_ti biological_process owl:Class
GO:0070056 biolink:NamedThing prospore membrane leading edge The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization. got7fsn_ti forespore membrane leading edge cellular_component owl:Class
GO:0016020 biolink:NamedThing membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. got7fsn_ti region of membrane|whole membrane|membrane region 2014-03-06T11:37:54Z GO:0098589|GO:0098805 Wikipedia:Biological_membrane cellular_component owl:Class
GO:0090697 biolink:NamedThing post-embryonic plant organ morphogenesis Morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti tb 2016-08-25T17:04:35Z biological_process owl:Class
GO:0090698 biolink:NamedThing post-embryonic plant morphogenesis The process, occurring after plant embryonic development, by which anatomical structures are generated and organized. got7fsn_ti tb 2016-08-25T17:08:33Z biological_process owl:Class
GO:0061826 biolink:NamedThing podosome ring The ring structure surrounding the podosome core, containing proteins such as vinculin and talin. got7fsn_ti dph 2017-01-14T14:44:53Z cellular_component owl:Class
GO:0051449 biolink:NamedThing thyrotropin-releasing hormone binding Binding to thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system. got7fsn_ti thyrotropin releasing hormone binding molecular_function owl:Class
GO:0017046 biolink:NamedThing peptide hormone binding Binding to a peptide with hormonal activity in animals. got7fsn_ti polypeptide hormone binding molecular_function owl:Class
GO:0015347 biolink:NamedThing sodium-independent organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. got7fsn_ti Reactome:R-HSA-879594|Reactome:R-HSA-9661723|Reactome:R-HSA-9661397|Reactome:R-HSA-879562|Reactome:R-HSA-9661446|Reactome:R-HSA-561059|Reactome:R-HSA-879584|Reactome:R-HSA-9661799 molecular_function owl:Class
GO:0008514 biolink:NamedThing organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. got7fsn_ti Reactome:R-HSA-2142859 molecular_function owl:Class
GO:1900053 biolink:NamedThing negative regulation of retinoic acid biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process. got7fsn_ti downregulation of retinoic acid anabolic process|inhibition of retinoic acid biosynthetic process|down regulation of retinoic acid biosynthetic process|down-regulation of retinoic acid biosynthetic process|negative regulation of retinoic acid anabolic process|downregulation of retinoic acid biosynthetic process|down regulation of retinoic acid anabolic process|down-regulation of retinoic acid anabolic process|inhibition of retinoic acid anabolic process yaf 2012-01-20T09:55:49Z biological_process owl:Class
GO:0046137 biolink:NamedThing negative regulation of vitamin metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti inhibition of vitamin metabolic process|down-regulation of vitamin metabolic process|down regulation of vitamin metabolic process|negative regulation of vitamin metabolism|downregulation of vitamin metabolic process biological_process owl:Class
GO:0103071 biolink:NamedThing 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA lyase activity Catalysis of the reaction: a 2-hydroxy-3-methyl-branched 2,3,4-saturated fatty acyl-CoA <=> formyl-CoA + a 2-methyl branched 2,3,4-saturated fatty aldehyde. got7fsn_ti MetaCyc:RXN66-471 molecular_function owl:Class
GO:0016830 biolink:NamedThing carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. got7fsn_ti other carbon-carbon lyase activity Reactome:R-HSA-389611|EC:4.1.-.- molecular_function owl:Class
GO:0008649 biolink:NamedThing rRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. got7fsn_ti molecular_function owl:Class
GO:0008173 biolink:NamedThing RNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. got7fsn_ti Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). Reactome:R-HSA-191784 molecular_function owl:Class
GO:0008738 biolink:NamedThing L-fuculose-phosphate aldolase activity Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate. got7fsn_ti L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)|fuculose aldolase activity|L-fuculose 1-phosphate aldolase activity|L-fuculose-1-phosphate lactaldehyde-lyase activity MetaCyc:FUCPALDOL-RXN|RHEA:12933|EC:4.1.2.17|KEGG_REACTION:R02262 molecular_function owl:Class
GO:0070976 biolink:NamedThing TIR domain binding Binding to a Toll-Interleukin receptor (TIR) domain of a protein. The TIR domain is an intracellular 200 residue domain that is found in the Toll protein, the interleukin-1 receptor (IL-1R), and MyD88; it contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. got7fsn_ti Toll-Interleukin receptor domain binding mah 2009-10-02T01:17:29Z molecular_function owl:Class
GO:0047685 biolink:NamedThing amine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an amine = adenosine 3',5'-bisphosphate + a sulfamate. got7fsn_ti arylamine sulfotransferase activity|3'-phosphoadenylyl-sulfate:amine N-sulfotransferase activity|amine N-sulfotransferase activity|amine sulphotransferase activity EC:2.8.2.3|MetaCyc:ARYLAMINE-SULFOTRANSFERASE-RXN|RHEA:24136 molecular_function owl:Class
GO:0008146 biolink:NamedThing sulfotransferase activity Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. got7fsn_ti sulphotransferase activity Reactome:R-HSA-2022061|EC:2.8.2.-|Reactome:R-HSA-176588|Reactome:R-HSA-176669|Reactome:R-HSA-176604 molecular_function owl:Class
GO:0016213 biolink:NamedThing linoleoyl-CoA desaturase activity Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O. got7fsn_ti fatty acid delta6-desaturase activity|linoleoyl CoA desaturase activity|delta6-desaturase activity|linoleate desaturase activity|linoleic desaturase activity|long-chain fatty acid delta(6)-desaturase activity|fatty acid delta(6)-desaturase activity|delta(6)-fatty acyl-CoA desaturase activity|delta6-acyl CoA desaturase activity|delta6-fatty acyl-CoA desaturase activity|long-chain fatty acid delta6-desaturase activity|linoleoyl-coenzyme A desaturase activity|delta(6)-desaturase activity|linoleic acid desaturase activity|delta(6)-acyl CoA desaturase activity|fatty acid 6-desaturase activity Note that this function was formerly EC:1.14.99.25. Reactome:R-HSA-2046084|EC:1.14.19.3|Reactome:R-HSA-2046096|MetaCyc:1.14.19.3-RXN|RHEA:22196|Reactome:R-HSA-2046097|Reactome:R-HSA-2046099 molecular_function owl:Class
GO:0016215 biolink:NamedThing acyl-CoA desaturase activity Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O. got7fsn_ti CoA desaturase activity https://github.com/geneontology/go-ontology/issues/21108 molecular_function owl:Class
GO:0021680 biolink:NamedThing cerebellar Purkinje cell layer development The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. got7fsn_ti biological_process owl:Class
GO:0009355 biolink:NamedThing DNA polymerase V complex A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis. got7fsn_ti cellular_component owl:Class
GO:0042575 biolink:NamedThing DNA polymerase complex A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. got7fsn_ti cellular_component owl:Class
GO:0031381 biolink:NamedThing viral RNA-directed RNA polymerase complex A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus. got7fsn_ti cellular_component owl:Class
GO:0031379 biolink:NamedThing RNA-directed RNA polymerase complex A protein complex that possesses RNA-directed RNA polymerase activity. got7fsn_ti cellular_component owl:Class
GO:0001634 biolink:NamedThing pituitary adenylate cyclase-activating polypeptide receptor activity A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide. got7fsn_ti pituitary adenylate cyclase-activating polypeptide receptor activity|pituitary adenylate cyclase activating polypeptide receptor|pituitary adenylate cyclase activating protein receptor activity|PACAP receptor|pituitary adenylate cyclase-activating peptide receptor activity|pituitary adenylyl cyclase activating protein receptor activity GO:0016522 molecular_function owl:Class
GO:0004930 biolink:NamedThing G protein-coupled receptor activity Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti SREB receptor|G protein linked receptor activity|G-protein coupled receptor activity|orphan GPCR activity|G-protein linked receptor activity|RDC1 receptor activity|orphan G-protein coupled receptor activity|super conserved receptor expressed in brain receptor activity|Mas proto-oncogene receptor activity|Epstein-Barr Virus-induced receptor activity|ligand-dependent GPCR activity|G protein coupled receptor activity|EBV-induced receptor|GPCR activity|G-protein coupled receptor activity, unknown ligand|orphan G protein coupled receptor activity|receptor activity, G-protein coupled GO:0001625|GO:0001623|GO:0016526|GO:0001624|GO:0001622 Wikipedia:GPCR|Reactome:R-HSA-167408|Reactome:R-HSA-114558|Reactome:R-HSA-114552 molecular_function owl:Class
GO:0042297 biolink:NamedThing vocal learning A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others. got7fsn_ti Examples include language learning by human infants and song learning in zebra finches. Wikipedia:Vocal_learning biological_process owl:Class
GO:0031223 biolink:NamedThing auditory behavior The behavior of an organism in response to a sound. got7fsn_ti behavioural response to sound|behavioral response to sound|auditory behaviour biological_process owl:Class
GO:0044741 biolink:NamedThing envenomation resulting in negative regulation of sensory perception of pain in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism. got7fsn_ti envenomation resulting in inhibition of sensory perception of pain in other organism jl 2012-11-07T14:02:14Z biological_process owl:Class
GO:0044742 biolink:NamedThing envenomation resulting in modulation of sensory perception of pain in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism. got7fsn_ti envenomation resulting in regulation of sensory perception of pain in other organism jl 2012-11-07T14:26:38Z biological_process owl:Class
GO:0090225 biolink:NamedThing regulation of spindle density Any process that modulates the number of microtubules in a given region of the spindle. got7fsn_ti tb 2010-01-13T11:24:53Z biological_process owl:Class
GO:0090224 biolink:NamedThing regulation of spindle organization Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle. got7fsn_ti regulation of spindle organisation tb 2010-01-13T11:04:53Z biological_process owl:Class
GO:0003419 biolink:NamedThing growth plate cartilage chondrocyte proliferation The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. got7fsn_ti dph 2009-12-22T09:02:51Z biological_process owl:Class
GO:0008283 biolink:NamedThing cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. got7fsn_ti cell proliferation This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. biological_process owl:Class
GO:0030445 biolink:NamedThing yeast-form cell wall The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form. got7fsn_ti See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'. cellular_component owl:Class
GO:0009277 biolink:NamedThing fungal-type cell wall A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure. got7fsn_ti chitin-containing cell wall|beta-glucan-containing cell wall|chitin- and beta-glucan-containing cell wall cellular_component owl:Class
GO:0051500 biolink:NamedThing D-tyrosyl-tRNA(Tyr) deacylase activity Catalysis of the reaction: D-tyrosyl-tRNA(Tyr) = D-tyrosine + tRNA(Tyr). Hydrolysis of the removal of D-tyrosine from tyrosine residues in charged tRNA. got7fsn_ti molecular_function owl:Class
GO:0051499 biolink:NamedThing D-aminoacyl-tRNA deacylase activity Catalysis of the reaction: D-aminoacyl-tRNA = D-amino acid + tRNA. Hydrolysis of the removal of D-amino acids from residues in charged tRNA. got7fsn_ti EC:3.1.1.96|MetaCyc:RXN-15041|RHEA:13953 molecular_function owl:Class
GO:0033592 biolink:NamedThing RNA strand annealing activity An activity that facilitates the formation of a complementary double-stranded RNA molecule. got7fsn_ti https://github.com/geneontology/go-ontology/issues/2161 molecular_function owl:Class
GO:0003727 biolink:NamedThing single-stranded RNA binding Binding to single-stranded RNA. got7fsn_ti ssRNA binding GO:0003728 molecular_function owl:Class
GO:0097668 biolink:NamedThing SCF-Saf1/Pof9 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe). got7fsn_ti pr 2014-10-06T10:28:30Z cellular_component owl:Class
GO:0048136 biolink:NamedThing male germ-line cyst formation Formation of a group of interconnected cells derived from a single male gonial founder cell. got7fsn_ti male germline cyst formation biological_process owl:Class
GO:0048134 biolink:NamedThing germ-line cyst formation Formation of a group of interconnected cells derived from a single gonial founder cell. got7fsn_ti germline cyst formation biological_process owl:Class
GO:0015233 biolink:NamedThing pantothenate transmembrane transporter activity Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. got7fsn_ti vitamin B5 transmembrane transporter activity|pantothenate transporter activity molecular_function owl:Class
GO:0090482 biolink:NamedThing vitamin transmembrane transporter activity Enables the transfer of a vitamin from one side of a membrane to the other. got7fsn_ti vitamin or cofactor transporter activity|vitamin transporter activity tb 2012-10-02T16:50:50Z GO:0051183 molecular_function owl:Class
GO:0004342 biolink:NamedThing glucosamine-6-phosphate deaminase activity Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+). got7fsn_ti phosphoglucosaminisomerase activity|glucosaminephosphate isomerase|glucosamine-6-phosphate isomerase activity|phosphoglucosamine isomerase activity|aminodeoxyglucosephosphate isomerase activity|GlcN6P deaminase activity|2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)|glucosamine phosphate deaminase activity Note that this function was formerly EC:5.3.1.10. Reactome:R-HSA-6799604|MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN|RHEA:12172|EC:3.5.99.6|KEGG_REACTION:R00765 molecular_function owl:Class
GO:0019239 biolink:NamedThing deaminase activity Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R). got7fsn_ti Reactome:R-HSA-9014641 molecular_function owl:Class
GO:0043629 biolink:NamedThing ncRNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation. got7fsn_ti non-coding RNA polyadenylation biological_process owl:Class
GO:0043631 biolink:NamedThing RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. got7fsn_ti biological_process owl:Class
GO:0001974 biolink:NamedThing blood vessel remodeling The reorganization or renovation of existing blood vessels. got7fsn_ti biological_process owl:Class
GO:0048771 biolink:NamedThing tissue remodeling The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling. got7fsn_ti biological_process owl:Class
GO:0008883 biolink:NamedThing glutamyl-tRNA reductase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH. got7fsn_ti L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming) EC:1.2.1.70|KEGG_REACTION:R04109|RHEA:12344|MetaCyc:GLUTRNAREDUCT-RXN molecular_function owl:Class
GO:0140101 biolink:NamedThing catalytic activity, acting on a tRNA Catalytic activity that acts to modify a tRNA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-15T18:41:41Z molecular_function owl:Class
GO:1902491 biolink:NamedThing negative regulation of sperm capacitation Any process that stops, prevents or reduces the frequency, rate or extent of sperm capacitation. got7fsn_ti down regulation of sperm activation|negative regulation of sperm activation|downregulation of sperm capacitation|down-regulation of sperm capacitation|down regulation of sperm capacitation|inhibition of sperm activation|down-regulation of sperm activation|inhibition of sperm capacitation|downregulation of sperm activation hjd 2013-11-12T21:17:12Z biological_process owl:Class
GO:1990530 biolink:NamedThing Cdc50p-Drs2p complex A protein complex that functions as a phospholipid-translocating P-Type ATPase. In budding yeast, this complex consists of Cdc50p and Drs2p proteins, and is involved in the trafficking of transport vesicles between the late Golgi and the early endosome. got7fsn_ti rb 2014-11-06T01:29:31Z cellular_component owl:Class
GO:1990531 biolink:NamedThing phospholipid-translocating ATPase complex A protein complex that functions as a phospholipid-translocating P-Type ATPase. got7fsn_ti CRF1-DNF3 complex|phospholipid flippase complex|CDC50-DRS2 complex|DNF3-CRF1 complex|APLT complex|DRS2-CDC50 complex|Dnf1-Lem3 complex|aminophospholipid translocase complex|Dnf2-Lem3 complex|Lem3-Dnf1 complex|P4-ATPase complex|Lem3p-Dnf1p complex rb 2014-11-06T22:33:25Z cellular_component owl:Class
GO:0047287 biolink:NamedThing lactosylceramide alpha-2,6-N-sialyltransferase activity Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,6-beta-galactosyl-1,4-beta-D-glucosylceramide + CMP. got7fsn_ti CMP-N-acetylneuraminate:lactosylceramide alpha-2,6-N-acetylneuraminyltransferase activity|CMP-sialic acid:lactosylceramide sialyltransferase activity|cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase|CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase activity|CMP-acetylneuraminate-lactosylceramide-sialyltransferase EC:2.4.99.11|MetaCyc:2.4.99.11-RXN|RHEA:21552 molecular_function owl:Class
GO:0008373 biolink:NamedThing sialyltransferase activity Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. got7fsn_ti Reactome:R-HSA-9697018|Reactome:R-HSA-981814|Reactome:R-HSA-9683769|Reactome:R-HSA-9694718 molecular_function owl:Class
GO:0061526 biolink:NamedThing acetylcholine secretion The regulated release of acetylcholine by a cell. got7fsn_ti dph 2013-06-21T15:40:39Z biological_process owl:Class
GO:0003219 biolink:NamedThing cardiac right ventricle formation The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts. got7fsn_ti dph 2009-10-13T09:55:38Z biological_process owl:Class
GO:0003211 biolink:NamedThing cardiac ventricle formation The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. got7fsn_ti dph 2009-10-13T09:46:27Z biological_process owl:Class
GO:0036343 biolink:NamedThing psychomotor behavior The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument. got7fsn_ti bf 2012-09-11T14:32:06Z biological_process owl:Class
GO:0061744 biolink:NamedThing motor behavior The specific neuromuscular movement of a single organism in response to external or internal stimuli. got7fsn_ti dph 2015-11-09T12:43:11Z biological_process owl:Class
GO:0050345 biolink:NamedThing trans-epoxysuccinate hydrolase activity Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate. got7fsn_ti tartrate epoxydase activity|trans-2,3-epoxysuccinate hydrolase activity|trans-epoxysuccinate hydratase activity RHEA:20740|EC:3.3.2.4|KEGG_REACTION:R02547|MetaCyc:TRANS-EPOXYSUCCINATE-HYDROLASE-RXN molecular_function owl:Class
GO:0016803 biolink:NamedThing ether hydrolase activity Catalysis of the hydrolysis of an ether bond, -O-. got7fsn_ti Reactome:R-HSA-8874435|EC:3.3.2.- molecular_function owl:Class
GO:0046726 biolink:NamedThing positive regulation by virus of viral protein levels in host cell Any process where the infecting virus increases the levels of viral proteins in a cell. got7fsn_ti activation of viral protein levels in host cell|up regulation of viral protein levels in host cell|upregulation of viral protein levels in host cell|up-regulation of viral protein levels in host cell|positive regulation of viral protein levels|stimulation of viral protein levels in host cell biological_process owl:Class
GO:0046719 biolink:NamedThing regulation by virus of viral protein levels in host cell Any virus-mediated process that modulates the levels of viral proteins in a cell. got7fsn_ti regulation of viral protein levels biological_process owl:Class
GO:0008119 biolink:NamedThing thiopurine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. got7fsn_ti thiopurine methyltransferase activity|mercaptopurine methyltransferase activity|TPMT|6-thiopurine transmethylase activity|S-adenosyl-L-methionine:thiopurine S-methyltransferase activity Reactome:R-HSA-5603379|MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN|Reactome:R-HSA-158609|EC:2.1.1.67 molecular_function owl:Class
GO:0008172 biolink:NamedThing S-methyltransferase activity Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. got7fsn_ti Reactome:R-HSA-209821|EC:2.1.1.- molecular_function owl:Class
GO:0001548 biolink:NamedThing follicular fluid formation in ovarian follicle antrum The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis. got7fsn_ti ovarian follicle antrum/follicular fluid biosynthesis|ovarian follicle antrum/follicular fluid formation biological_process owl:Class
GO:0022602 biolink:NamedThing ovulation cycle process A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. got7fsn_ti estrous cycle process|menstrual cycle process biological_process owl:Class
GO:0008587 biolink:NamedThing imaginal disc-derived wing margin morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade. got7fsn_ti wing margin morphogenesis See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'. biological_process owl:Class
GO:0046309 biolink:NamedThing 1,3-dichloro-2-propanol biosynthetic process The chemical reactions and pathways resulting in the formation of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. got7fsn_ti 1,3-dichloro-2-propanol biosynthesis|1,3-dichloro-2-propanol synthesis|1,3-dichloro-2-propanol anabolism|1,3-dichloro-2-propanol formation biological_process owl:Class
GO:0033268 biolink:NamedThing node of Ranvier An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. got7fsn_ti node of Ranvier axon NIF_Subcellular:birnlex_1152_2|Wikipedia:Nodes_of_Ranvier cellular_component owl:Class
GO:0010218 biolink:NamedThing response to far red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti response to far red light stimulus biological_process owl:Class
GO:0030879 biolink:NamedThing mammary gland development The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages. got7fsn_ti mammogenesis biological_process owl:Class
GO:0031352 biolink:NamedThing intrinsic component of plastid inner membrane The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to plastid inner membrane cellular_component owl:Class
GO:0031350 biolink:NamedThing intrinsic component of plastid membrane The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to plastid membrane cellular_component owl:Class
GO:0035124 biolink:NamedThing embryonic caudal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. got7fsn_ti biological_process owl:Class
GO:0035143 biolink:NamedThing caudal fin morphogenesis The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion. got7fsn_ti biological_process owl:Class
GO:0102978 biolink:NamedThing furaneol oxidoreductase activity Catalysis of the reaction: 4-hydroxy-2,5-dimethylfuran-3-one + NADP <=> 4-hydroxy-5-methyl-2-methylenefuran-3-one + NADPH + H+. got7fsn_ti EC:1.3.1.105|RHEA:39111|MetaCyc:RXN-9563 molecular_function owl:Class
GO:0075510 biolink:NamedThing macropinocytosis involved in viral entry into host cell Any macropinocytosis that is involved in the uptake of a virus into a host cell. got7fsn_ti viral entry into host cell via macropinocytosis jl 2011-07-27T11:24:59Z VZ:800 biological_process owl:Class
GO:0075509 biolink:NamedThing endocytosis involved in viral entry into host cell Any endocytosis that is involved in the uptake of a virus into a host cell. got7fsn_ti virus endocytosis by host|viral penetration via endocytosis followed by endosome disruption|viral entry into host cell via endocytosis jl 2011-07-27T11:06:34Z VZ:977 biological_process owl:Class
GO:0050904 biolink:NamedThing diapedesis The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. got7fsn_ti Note that the term diapedesis, although sometimes used as a direct synonym for cellular extravasation, is used here for the specific final step of the process, in concordance with recent reviews of the topic. biological_process owl:Class
GO:0050900 biolink:NamedThing leukocyte migration The movement of a leukocyte within or between different tissues and organs of the body. got7fsn_ti immune cell trafficking|leucocyte migration|leukocyte trafficking|leucocyte trafficking|immune cell migration biological_process owl:Class
GO:0034983 biolink:NamedThing peptidyl-lysine deacetylation The removal of an acetyl group from an acetylated lysine residue in a peptide or protein. got7fsn_ti protein lysine acetylation biological_process owl:Class
GO:0034689 biolink:NamedThing integrin alphaX-beta2 complex An integrin complex that comprises one alphaX subunit and one beta2 subunit. got7fsn_ti alphaX-beta2 integrin complex|Itgax-Itgb2 complex cellular_component owl:Class
GO:0008305 biolink:NamedThing integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. got7fsn_ti laminin receptor protein cellular_component owl:Class
GO:0090174 biolink:NamedThing organelle membrane fusion The joining of two lipid bilayers to form a single organelle membrane. got7fsn_ti tb 2009-12-11T11:44:58Z biological_process owl:Class
GO:0048284 biolink:NamedThing organelle fusion The creation of a single organelle from two or more organelles. got7fsn_ti biological_process owl:Class
GO:0022608 biolink:NamedThing multicellular organism adhesion The attachment of a multicellular organism to a substrate or other organism. got7fsn_ti biological_process owl:Class
GO:0032501 biolink:NamedThing multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. got7fsn_ti single-multicellular organism process|organismal physiological process jl 2012-09-19T16:07:47Z GO:0050874|GO:0044707 biological_process owl:Class
GO:0044392 biolink:NamedThing peptidyl-lysine malonylation The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine. got7fsn_ti lysine malonylation bf 2011-12-12T09:31:42Z RESID:AA0568 biological_process owl:Class
GO:0044394 biolink:NamedThing protein malonylation The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group. got7fsn_ti bf 2011-12-12T09:26:37Z biological_process owl:Class
GO:0102060 biolink:NamedThing endo-alpha-bergamotene synthase activity Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (-)-endo-alpha-bergamotene + diphosphoric acid. got7fsn_ti endo-alpha-bergamontene synthase activity RHEA:30471|MetaCyc:RXN-10482|EC:4.2.3.54 molecular_function owl:Class
GO:0008033 biolink:NamedThing tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. got7fsn_ti tRNA maturation biological_process owl:Class
GO:0006399 biolink:NamedThing tRNA metabolic process The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established. got7fsn_ti tRNA metabolism biological_process owl:Class
GO:0046810 biolink:NamedThing host cell extracellular matrix binding Binding to the extracellular matrix of a host cell. got7fsn_ti molecular_function owl:Class
GO:0050840 biolink:NamedThing extracellular matrix binding Binding to a component of the extracellular matrix. got7fsn_ti adhesive extracellular matrix constituent|extracellular matrix constituent binding molecular_function owl:Class
GO:0003953 biolink:NamedThing NAD+ nucleosidase activity Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. got7fsn_ti NAD nucleosidase activity Reactome:R-HSA-8938076|Reactome:R-HSA-8870346|RHEA:16301 molecular_function owl:Class
GO:0016799 biolink:NamedThing hydrolase activity, hydrolyzing N-glycosyl compounds Catalysis of the hydrolysis of any N-glycosyl bond. got7fsn_ti EC:3.2.2.- molecular_function owl:Class
GO:0042015 biolink:NamedThing interleukin-20 binding Binding to interleukin-20. got7fsn_ti IL-20 binding molecular_function owl:Class
GO:0019955 biolink:NamedThing cytokine binding Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. got7fsn_ti interleukin binding|IL binding GO:0019965 molecular_function owl:Class
GO:0005594 biolink:NamedThing collagen type IX trimer A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils. got7fsn_ti cellular_component owl:Class
GO:0005593 biolink:NamedThing FACIT collagen trimer A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences. got7fsn_ti The acronym FACIT stands for fibril-associated collagen with interrupted triple helix. Wikipedia:FACIT_collagen cellular_component owl:Class
GO:0046786 biolink:NamedThing viral replication complex formation and maintenance The process of organizing and assembling viral replication proteins in preparation for viral replication. got7fsn_ti biological_process owl:Class
GO:0097400 biolink:NamedThing interleukin-17-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-17 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-17-mediated signalling pathway|IL-17-mediated signalling pathway|IL-17-mediated signaling pathway pr 2012-10-23T13:30:03Z biological_process owl:Class
GO:0019221 biolink:NamedThing cytokine-mediated signaling pathway A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti cytokine mediated signalling pathway|cytokine and chemokine mediated signaling pathway biological_process owl:Class
GO:0043291 biolink:NamedThing RAVE complex A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme. got7fsn_ti regulator of the (H+)-ATPase of the vacuolar and endosomal membranes cellular_component owl:Class
GO:0061263 biolink:NamedThing mesonephric glomerular mesangial cell development The process whose specific outcome is the progression of a glomerular mesangial cell in the mesonephros over time, from its formation to the mature structure. got7fsn_ti dph 2010-08-30T02:52:55Z biological_process owl:Class
GO:0072144 biolink:NamedThing glomerular mesangial cell development The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure. got7fsn_ti mah 2010-02-24T01:53:13Z biological_process owl:Class
GO:0071788 biolink:NamedThing endoplasmic reticulum tubular network maintenance The organization process that preserves the endoplasmic reticulum (ER) tubular network in a stable functional or structural state. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. got7fsn_ti ER tubular network maintenance mah 2010-09-01T01:55:06Z biological_process owl:Class
GO:0043954 biolink:NamedThing cellular component maintenance The organization process that preserves a cellular component in a stable functional or structural state. got7fsn_ti cellular component maintenance at cellular level GO:0071956 biological_process owl:Class
GO:0018733 biolink:NamedThing 3,4-dihydrocoumarin hydrolase activity Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate. got7fsn_ti UM-BBD_reactionID:r0419|EC:3.1.1.35 molecular_function owl:Class
GO:0043027 biolink:NamedThing cysteine-type endopeptidase inhibitor activity involved in apoptotic process Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. got7fsn_ti caspase inhibitor activity molecular_function owl:Class
GO:0043028 biolink:NamedThing cysteine-type endopeptidase regulator activity involved in apoptotic process Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. got7fsn_ti caspase regulator activity molecular_function owl:Class
GO:0050708 biolink:NamedThing regulation of protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell. got7fsn_ti biological_process owl:Class
GO:0051223 biolink:NamedThing regulation of protein transport Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0050778 biolink:NamedThing positive regulation of immune response Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. got7fsn_ti upregulation of immune response|stimulation of immune response|up-regulation of immune response|up regulation of immune response biological_process owl:Class
GO:0050776 biolink:NamedThing regulation of immune response Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. got7fsn_ti biological_process owl:Class
GO:0034667 biolink:NamedThing integrin alpha3-beta1 complex An integrin complex that comprises one alpha3 subunit and one beta1 subunit. got7fsn_ti VLA-3 complex|alpha3-beta1 integrin complex|ITGA3-ITGB1 complex cellular_component owl:Class
GO:0007602 biolink:NamedThing phototransduction The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. got7fsn_ti phototrophin mediated phototransduction|opsin|phototransduction, visible light, light adaptation Wikipedia:Visual_phototransduction biological_process owl:Class
GO:0007165 biolink:NamedThing signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. got7fsn_ti signal transduction by cis-phosphorylation|signalling pathway|signalling cascade|signal transduction by protein phosphorylation|signaling cascade|signal transduction by trans-phosphorylation|signal transduction by conformational transition|signaling pathway Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. GO:0023015|GO:0023045|GO:0023014|GO:0023033|GO:0023016 Wikipedia:Signal_transduction biological_process owl:Class
GO:0061709 biolink:NamedThing reticulophagy The selective autohagy process in which parts of the endoplasmic reticulum are loaded into autophagosomes, delivered to the vacuole, and degraded in response to changing cellular conditions. got7fsn_ti autophagy of the endoplasmic reticulum|endoplasmic reticulum degradation|ER-phagy|ER degradation|autophagy of the ER|endoplasmic reticulum autophagy|ER autophagy dph 2015-06-18T15:15:48Z GO:1990766 biological_process owl:Class
GO:1903008 biolink:NamedThing organelle disassembly The disaggregation of an organelle into its constituent components. got7fsn_ti organelle degradation jl 2014-05-13T12:36:03Z biological_process owl:Class
GO:0032985 biolink:NamedThing protein-carbohydrate complex disassembly The disaggregation of a protein-carbohydrate complex into its constituent components. got7fsn_ti biological_process owl:Class
GO:0071823 biolink:NamedThing protein-carbohydrate complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex. got7fsn_ti protein-carbohydrate complex subunit organisation mah 2010-09-08T10:03:03Z biological_process owl:Class
GO:0043326 biolink:NamedThing chemotaxis to folate The directed movement of a motile cell or organism in response to the presence of folate. got7fsn_ti biological_process owl:Class
GO:0006935 biolink:NamedThing chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti taxis in response to chemical stimulus Wikipedia:Chemotaxis biological_process owl:Class
GO:0000269 biolink:NamedThing toxin export channel activity Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. got7fsn_ti molecular_function owl:Class
GO:0075239 biolink:NamedThing zoospore formation The process in which a diploid cell undergoes meiosis, and the meiotic products acquire specialized features of asexual motile mononucleate flagellated spores called zoospores. got7fsn_ti biological_process owl:Class
GO:0033012 biolink:NamedThing porosome A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles. got7fsn_ti Wikipedia:Porosome cellular_component owl:Class
GO:0008986 biolink:NamedThing pyruvate, water dikinase activity Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate. got7fsn_ti phosphopyruvate synthetase activity|pyruvate-water dikinase (phosphorylating)|pyruvate,water dikinase activity|water pyruvate dikinase activity|ATP:pyruvate, water phosphotransferase activity|phoephoenolpyruvate synthetase activity|PEP synthase activity|phosphoenolpyruvic synthase activity|phosphoenolpyruvate synthase activity|PEP synthetase activity MetaCyc:PEPSYNTH-RXN|RHEA:11364|EC:2.7.9.2|KEGG_REACTION:R00199 molecular_function owl:Class
GO:0016301 biolink:NamedThing kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. got7fsn_ti phosphokinase activity Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. Reactome:R-HSA-6788855|Reactome:R-HSA-6788867 molecular_function owl:Class
GO:0003875 biolink:NamedThing ADP-ribosylarginine hydrolase activity Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose. got7fsn_ti ADPribosylarginine hydrolase activity|ADP-ribose-L-arginine cleaving enzyme activity|ADP-ribose-L-arginine cleavage enzyme activity|protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity|protein ADP-ribosylarginine hydrolase activity|N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity RHEA:20784|EC:3.2.2.19|MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN molecular_function owl:Class
GO:0061756 biolink:NamedThing leukocyte adhesion to vascular endothelial cell The attachment of a leukocyte to vascular endothelial cell via adhesion molecules. got7fsn_ti dph 2016-02-29T16:42:11Z biological_process owl:Class
GO:0007159 biolink:NamedThing leukocyte cell-cell adhesion The attachment of a leukocyte to another cell via adhesion molecules. got7fsn_ti leukocyte cell adhesion|leukocyte adhesion biological_process owl:Class
GO:0004877 biolink:NamedThing complement component C3b receptor activity Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0004875 biolink:NamedThing complement receptor activity Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti anaphylatoxin receptor activity Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. GO:0004942 molecular_function owl:Class
GO:0048006 biolink:NamedThing antigen processing and presentation, endogenous lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen of endogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. got7fsn_ti antigen presentation, endogenous lipid antigen|endogenous lipid antigen processing and presentation via MHC class Ib biological_process owl:Class
GO:0048003 biolink:NamedThing antigen processing and presentation of lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen in association with an MHC class Ib protein complex on its cell surface, including lipid extraction, degradation, and transport steps for the lipid antigen both prior to and following assembly with the MHC protein complex. The lipid antigen may originate from an endogenous or exogenous source of lipid. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. got7fsn_ti lipid antigen processing and presentation via MHC class Ib|antigen presentation, lipid antigen biological_process owl:Class
GO:0048614 biolink:NamedThing post-embryonic ectodermal digestive tract morphogenesis The process, occurring during the post-embryonic phase, by which the anatomical structures of the ectodermal gut are generated and organized. got7fsn_ti post-embryonic ectodermal gut morphogenesis biological_process owl:Class
GO:0045496 biolink:NamedThing male analia development The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0007487 biolink:NamedThing analia development The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0043114 biolink:NamedThing regulation of vascular permeability Any process that modulates the extent to which blood vessels can be pervaded by fluid. got7fsn_ti biological_process owl:Class
GO:0003018 biolink:NamedThing vascular process in circulatory system A circulatory process that occurs at the level of the vasculature. got7fsn_ti vasculature process biological_process owl:Class
GO:0070978 biolink:NamedThing voltage-gated calcium channel complex assembly Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex. got7fsn_ti mah 2009-10-06T04:51:13Z biological_process owl:Class
GO:0034622 biolink:NamedThing cellular protein-containing complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. got7fsn_ti cellular macromolecule complex assembly|cellular protein complex assembly GO:0043623 biological_process owl:Class
GO:0034558 biolink:NamedThing technetium (VII) reductase activity Catalysis of the reaction: pertechnetate ion + 3/2 H2 = technetium (IV) oxide + H2O + OH-. got7fsn_ti UM-BBD_reactionID:r0859 molecular_function owl:Class
GO:0016695 biolink:NamedThing oxidoreductase activity, acting on hydrogen as donor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor. got7fsn_ti oxidoreductase activity, acting on hydrogen as donor, other acceptors EC:1.12.-.- molecular_function owl:Class
GO:0051844 biolink:NamedThing translocation of peptides or proteins into symbiont The directed movement of peptides or proteins produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti transport of peptides or proteins into symbiont biological_process owl:Class
GO:0051862 biolink:NamedThing translocation of molecules into symbiont The directed movement of molecule(s) produced by an organism to a location inside the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti transport of molecules into symbiont biological_process owl:Class
GO:0099004 biolink:NamedThing calmodulin dependent kinase signaling pathway Any signal transduction pathway involving calmodulin dependent kinase activity. got7fsn_ti CAMK signaling pathway biological_process owl:Class
GO:0102817 biolink:NamedThing caffeoyl-CoA:3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) 3'-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + caffeoyl-CoA <=> gentiodelphin + coenzyme A. got7fsn_ti MetaCyc:RXN-8235 molecular_function owl:Class
GO:0051747 biolink:NamedThing cytosine C-5 DNA demethylase activity Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA. got7fsn_ti DNA methyltransferase activity acting on cytosine C-5|DNA demethylase activity|hydrolytic DNA demethylase activity molecular_function owl:Class
GO:0140097 biolink:NamedThing catalytic activity, acting on DNA Catalytic activity that acts to modify DNA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-14T12:03:51Z molecular_function owl:Class
GO:0009589 biolink:NamedThing detection of UV The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. got7fsn_ti perception of UV|detection of ultraviolet light stimulus|detection of ultraviolet radiation stimulus|detection of UV radiation stimulus|detection of UV light stimulus biological_process owl:Class
GO:0009411 biolink:NamedThing response to UV Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. got7fsn_ti response to ultraviolet light stimulus|response to UV radiation stimulus|response to ultraviolet radiation stimulus|response to UV light stimulus biological_process owl:Class
GO:1990385 biolink:NamedThing meiotic spindle midzone The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap. got7fsn_ti kmv 2014-05-29T20:52:44Z cellular_component owl:Class
GO:0051233 biolink:NamedThing spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap. got7fsn_ti spindle equator|central spindle cellular_component owl:Class
GO:0061627 biolink:NamedThing S-methylmethionine-homocysteine S-methyltransferase activity Catalysis of the reaction: S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H+. got7fsn_ti homocysteine transmethylase activity|methylmethionine:homocysteine methyltransferase activity|S-methylmethionine homocysteine transmethylase activity|homocysteine methyltransferase activity dph 2014-05-14T14:32:02Z Reactome:R-HSA-5696838|RHEA:26337 molecular_function owl:Class
GO:0031463 biolink:NamedThing Cul3-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein. got7fsn_ti CDL3 complex|BCR3 complex|cullin-RING ligase 3|BC3B complex|CRL3 complex|SCF3 complex cellular_component owl:Class
GO:0031461 biolink:NamedThing cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. got7fsn_ti CRL complex|cullin complex|cullin-RING ligase cellular_component owl:Class
GO:0072376 biolink:NamedThing protein activation cascade A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events. got7fsn_ti protein activitory cascade|protein activation pathway mah 2010-11-22T02:54:18Z biological_process owl:Class
GO:0019538 biolink:NamedThing protein metabolic process The chemical reactions and pathways involving a protein. Includes protein modification. got7fsn_ti protein metabolic process and modification|protein metabolism|protein metabolism and modification|multicellular organismal protein metabolic process GO:0006411|GO:0044268 Wikipedia:Protein_metabolism biological_process owl:Class
GO:0075137 biolink:NamedThing response to host redox environment Any process that results in a change in state or activity of the symbiont organism or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the redox environment in host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response of symbiont to host redox environment Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class
GO:0075136 biolink:NamedThing response to host Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response of symbiont to host Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class
GO:0102040 biolink:NamedThing fumarate reductase (menaquinone) Catalysis of the reaction: fumarate + a menaquinol = succinate + a menaquinone. got7fsn_ti EC:1.3.5.4|MetaCyc:R601-RXN|RHEA:27834 molecular_function owl:Class
GO:0016635 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound. got7fsn_ti EC:1.3.5.- molecular_function owl:Class
GO:0080041 biolink:NamedThing ADP-ribose pyrophosphohydrolase activity Catalysis of the reaction: ADP-ribose + H2O = AMP + ribose-1-phosphate. got7fsn_ti molecular_function owl:Class
GO:0019144 biolink:NamedThing ADP-sugar diphosphatase activity Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate. got7fsn_ti ADP-sugar pyrophosphatase activity|ADP-sugar sugarphosphohydrolase activity|nucleoside diphosphate-sugar hydrolase activity|adenosine diphosphosugar pyrophosphatase activity|ADPsugar pyrophosphatase activity EC:3.6.1.21|MetaCyc:ADPSUGPPHOSPHAT-RXN molecular_function owl:Class
GO:1990334 biolink:NamedThing Bfa1-Bub2 complex A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation. got7fsn_ti bhm 2014-03-17T14:34:21Z cellular_component owl:Class
GO:1902773 biolink:NamedThing GTPase activator complex A protein complex which is capable of GTPase activator activity. got7fsn_ti An example of this is BFA1 in Saccharomyces cerevisiae (P47113) in PMID:16449187 (inferred from direct assay). bhm 2014-03-17T14:26:08Z cellular_component owl:Class
GO:0035233 biolink:NamedThing germ cell repulsion The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue. got7fsn_ti biological_process owl:Class
GO:0060326 biolink:NamedThing cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti biological_process owl:Class
GO:0007588 biolink:NamedThing excretion The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds. got7fsn_ti Wikipedia:Excretion biological_process owl:Class
GO:0003008 biolink:NamedThing system process A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. got7fsn_ti organ system process biological_process owl:Class
GO:0004465 biolink:NamedThing lipoprotein lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. got7fsn_ti postheparin esterase activity|clearing factor lipase activity|postheparin lipase activity|lipemia-clearing factor|diacylglycerol lipase activity|diglyceride lipase activity|triacylglycero-protein acylhydrolase activity|diacylglycerol hydrolase activity EC:3.1.1.34|Reactome:R-HSA-174757|Reactome:R-HSA-8979996|Reactome:R-HSA-1482811|Reactome:R-HSA-6789310|Reactome:R-HSA-2395768|MetaCyc:LIPOPROTEIN-LIPASE-RXN|Reactome:R-HSA-8980228 molecular_function owl:Class
GO:0004806 biolink:NamedThing triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. got7fsn_ti triglyceridase activity|glycerol ester hydrolase activity|amano B|triacylglycerol ester hydrolase activity|tween-hydrolyzing esterase activity|tweenesterase activity|amno N-AP|triacylglycerol acylhydrolase activity|tweenase activity|salt-resistant post-heparin lipase|triolein hydrolase activity|triglyceride hydrolase activity|hepatic monoacylglycerol acyltransferase|amano P|triacylglycerol lipase activity|amano CE|meito MY 30|GA 56|butyrinase activity|GEH|takedo 1969-4-9|tributyrinase activity|amano AP|meito sangyo OF lipase|capalase L|glycerol-ester hydrolase activity|amano CES|tributyrin esterase activity|tributyrase activity|liver lipase|TAG activity|post-heparin plasma protamine-resistant lipase|steapsin|tween hydrolase activity|PPL|lipazin|hepatic lipase|cacordase activity|triacetinase activity|heparin releasable hepatic lipase Reactome:R-HSA-8848339|Reactome:R-HSA-1482777|Reactome:R-HSA-8848338|Reactome:R-HSA-163551|RHEA:12044|EC:3.1.1.3|MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN|Reactome:R-HSA-5694109 molecular_function owl:Class
GO:0060086 biolink:NamedThing circadian temperature homeostasis Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours. got7fsn_ti circadian thermoregulation|circadian regulation of body temperature biological_process owl:Class
GO:0001659 biolink:NamedThing temperature homeostasis A homeostatic process in which an organism modulates its internal body temperature. got7fsn_ti thermoregulation Wikipedia:Thermoregulation biological_process owl:Class
GO:0120230 biolink:NamedThing recombinase activator activity Binds to and increases the activity of a recombinase. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19631|https://github.com/geneontology/go-ontology/issues/19555 krc 2020-06-18T15:54:26Z molecular_function owl:Class
GO:0008047 biolink:NamedThing enzyme activator activity Binds to and increases the activity of an enzyme. got7fsn_ti metalloenzyme activator activity This term should only be used in cases when the regulator directly interacts with the enzyme. GO:0010577 molecular_function owl:Class
GO:0021856 biolink:NamedThing hypothalamic tangential migration using cell-axon interactions The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons. got7fsn_ti biological_process owl:Class
GO:0021855 biolink:NamedThing hypothalamus cell migration The directed movement of a cell into the hypothalamus region of the forebrain. got7fsn_ti biological_process owl:Class
GO:0010850 biolink:NamedThing regulation of blood pressure by chemoreceptor signaling pathway A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. got7fsn_ti regulation of blood pressure by chemoreceptor signalling pathway biological_process owl:Class
GO:0008217 biolink:NamedThing regulation of blood pressure Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. got7fsn_ti control of blood pressure|blood pressure regulation|blood pressure homeostasis Wikipedia:Blood_pressure#Regulation biological_process owl:Class
GO:0031322 biolink:NamedThing ascospore-type prospore-specific spindle pole body remodeling A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP). got7fsn_ti forespore specific spindle pole body remodeling|ascospore-type prospore-specific spindle pole body remodelling|prospore-specific spindle pole body remodeling|forespore-specific spindle pole body remodeling|sporulation-specific spindle pole body remodeling|ascospore-type prospore-specific spindle pole body modification biological_process owl:Class
GO:0106358 biolink:NamedThing glycerol-1-phosphate dehydrogenase [NADP+] activity Catalysis of the reaction: NADP+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADPH. got7fsn_ti hjd 2021-02-02T06:08:14Z RHEA:21416 molecular_function owl:Class
GO:0050492 biolink:NamedThing glycerol-1-phosphate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate. got7fsn_ti sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase activity EC:1.1.1.261|MetaCyc:1.1.1.261-RXN molecular_function owl:Class
GO:0033825 biolink:NamedThing oligosaccharide 4-alpha-D-glucosyltransferase activity Catalysis of the transfer of the non-reducing terminal alpha-D-glucose residue from a 1,4-alpha-D-glucan to the 4-position of an alpha-D-glucan, thus bringing about the hydrolysis of oligosaccharides. got7fsn_ti amylase III activity|1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|1,4-alpha-glucan:1,4-alpha-glucan 4-alpha-glucosyltransferase activity EC:2.4.1.161|MetaCyc:2.4.1.161-RXN molecular_function owl:Class
GO:0046664 biolink:NamedThing dorsal closure, amnioserosa morphology change The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo. got7fsn_ti biological_process owl:Class
GO:0048729 biolink:NamedThing tissue morphogenesis The process in which the anatomical structures of a tissue are generated and organized. got7fsn_ti biological_process owl:Class
GO:1903431 biolink:NamedThing positive regulation of cell maturation Any process that activates or increases the frequency, rate or extent of cell maturation. got7fsn_ti up regulation of functional differentiation|positive regulation of functional differentiation|upregulation of functional differentiation|upregulation of cell maturation|activation of functional differentiation|activation of cell maturation|up-regulation of cell maturation|up regulation of cell maturation|up-regulation of functional differentiation jl 2014-09-15T13:31:41Z biological_process owl:Class
GO:0010720 biolink:NamedThing positive regulation of cell development Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:1990484 biolink:NamedThing aerobic lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen. got7fsn_ti aerobic lactic acid catabolic process tt 2014-09-20T05:42:51Z biological_process owl:Class
GO:1903457 biolink:NamedThing lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate. got7fsn_ti lactate catabolism|lactate degradation|lactate breakdown pr 2014-09-23T08:41:03Z biological_process owl:Class
GO:0044562 biolink:NamedThing envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism. got7fsn_ti jl 2012-04-05T04:01:49Z biological_process owl:Class
GO:0044559 biolink:NamedThing envenomation resulting in modulation of voltage-gated potassium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism. got7fsn_ti jl 2012-04-05T03:35:20Z biological_process owl:Class
GO:0009720 biolink:NamedThing detection of hormone stimulus The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of hormone stimulus biological_process owl:Class
GO:0009725 biolink:NamedThing response to hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. got7fsn_ti response to hormone stimulus|growth regulator biological_process owl:Class
GO:0070529 biolink:NamedThing L-tryptophan aminotransferase activity Catalysis of the transfer of an amino group from L-tryptophan to an acceptor, usually a 2-oxo acid. got7fsn_ti molecular_function owl:Class
GO:0051015 biolink:NamedThing actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. got7fsn_ti F-actin binding|actin cross-linking activity molecular_function owl:Class
GO:0003779 biolink:NamedThing actin binding Binding to monomeric or multimeric forms of actin, including actin filaments. got7fsn_ti membrane associated actin binding molecular_function owl:Class
GO:0042795 biolink:NamedThing snRNA transcription by RNA polymerase II The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter. got7fsn_ti snRNA transcription from RNA polymerase II promoter|snRNA transcription from Pol II promoter https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0006366 biolink:NamedThing transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). got7fsn_ti specific transcription from RNA polymerase II promoter|transcription from Pol II promoter|transcription from RNA polymerase II promoter|gene-specific transcription from RNA polymerase II promoter|general transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity https://github.com/geneontology/go-ontology/issues/14854 GO:0032568|GO:0032569 biological_process owl:Class
GO:0050878 biolink:NamedThing regulation of body fluid levels Any process that modulates the levels of body fluids. got7fsn_ti biological_process owl:Class
GO:0001791 biolink:NamedThing IgM binding Binding to an immunoglobulin of the IgM isotype. got7fsn_ti molecular_function owl:Class
GO:0019865 biolink:NamedThing immunoglobulin binding Binding to an immunoglobulin. got7fsn_ti molecular_function owl:Class
GO:0075526 biolink:NamedThing cap snatching A transcription initiation process during which a nucleotide sequence between 10 and 20 nucleotides in size is cleaved from the 5' end of host mRNAs by a viral RNA-dependent polymerase. The capped leader sequence obtained is subsequently used to prime transcription on the viral genome, which ultimately leads to the synthesis of capped, translatable viral mRNAs. got7fsn_ti cap snatching involved in viral mRNA transcription jl 2011-08-04T01:19:00Z VZ:839 biological_process owl:Class
GO:0075221 biolink:NamedThing negative regulation of zoospore encystment on host Any process that stops, prevents, or reduces the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0075219 biolink:NamedThing modulation of zoospore encystment on host Any process that modulates the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0016416 biolink:NamedThing O-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule. got7fsn_ti Reactome:R-HSA-2466710|Reactome:R-HSA-2453855|Reactome:R-HSA-2404137 molecular_function owl:Class
GO:0008374 biolink:NamedThing O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. got7fsn_ti Reactome:R-HSA-1482867|Reactome:R-HSA-1482850|Reactome:R-HSA-5483229|Reactome:R-HSA-1482781|Reactome:R-HSA-1482775|Reactome:R-HSA-162683|Reactome:R-HSA-422017|Reactome:R-HSA-5358343|Reactome:R-HSA-3238694|Reactome:R-HSA-422104|Reactome:R-HSA-1482861 molecular_function owl:Class
GO:0140084 biolink:NamedThing sexual macrocyst formation The fusion of haploid amoebae cells with matching mating types to form a larger cell, which ingests additional amoebae and forms a cellulose wall. The resulting macrocyst undergoes recombination and meiosis followed by release of haploid amoebae. An example of this process can be found in Dictyostelium discoideum. got7fsn_ti macrocyst formation|sexual fusion pg 2017-08-14T20:11:03Z biological_process owl:Class
GO:0019953 biolink:NamedThing sexual reproduction A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny. got7fsn_ti Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. Wikipedia:Sexual_reproduction biological_process owl:Class
GO:0021890 biolink:NamedThing olfactory bulb interneuron fate commitment The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb. got7fsn_ti biological_process owl:Class
GO:0048663 biolink:NamedThing neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron. got7fsn_ti neuronal lineage restriction|neuron lineage restriction GO:0042055 biological_process owl:Class
GO:0005622 biolink:NamedThing intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. got7fsn_ti intracellular|internal to cell|nucleocytoplasm|protoplasm|protoplast https://github.com/geneontology/go-ontology/issues/17776 Wikipedia:Intracellular cellular_component owl:Class
GO:0003262 biolink:NamedThing endocardial progenitor cell migration to the midline involved in heart field formation The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart. got7fsn_ti dph 2009-10-15T02:00:41Z biological_process owl:Class
GO:0060975 biolink:NamedThing cardioblast migration to the midline involved in heart field formation The orderly movement of a cardioblast toward the midline to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti cardioblast midline convergence|cardiac progenitor cell midline migration dph 2009-10-06T10:59:36Z biological_process owl:Class
GO:0010316 biolink:NamedThing pyrophosphate-dependent phosphofructokinase complex Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate. got7fsn_ti PFK complex cellular_component owl:Class
GO:0061660 biolink:NamedThing Atg12 ligase activity Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T13:50:42Z molecular_function owl:Class
GO:0061659 biolink:NamedThing ubiquitin-like protein ligase activity Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3|small conjugating protein ligase activity dph 2014-11-06T13:46:23Z molecular_function owl:Class
GO:0106370 biolink:NamedThing protein-L-histidine N-pros-methyltransferase activity Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine. got7fsn_ti hjd 2021-03-22T15:13:06Z RHEA:67076 molecular_function owl:Class
GO:0008757 biolink:NamedThing S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. got7fsn_ti SAM-dependent methyltransferase activity|S-adenosyl methionine-dependent methyltransferase activity molecular_function owl:Class
GO:0071356 biolink:NamedThing cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. got7fsn_ti cellular response to TNF mah 2009-12-11T02:51:37Z biological_process owl:Class
GO:0034612 biolink:NamedThing response to tumor necrosis factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus. got7fsn_ti response to TNF biological_process owl:Class
GO:0043488 biolink:NamedThing regulation of mRNA stability Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. got7fsn_ti biological_process owl:Class
GO:0043487 biolink:NamedThing regulation of RNA stability Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs. got7fsn_ti biological_process owl:Class
GO:0048343 biolink:NamedThing paraxial mesodermal cell fate commitment The process in which a cell becomes committed to become a paraxial mesoderm cell. got7fsn_ti biological_process owl:Class
GO:0001710 biolink:NamedThing mesodermal cell fate commitment The cell differentiation process that results in commitment of a cell to become part of the mesoderm. got7fsn_ti mesoderm cell fate commitment biological_process owl:Class
GO:0120174 biolink:NamedThing stress-induced homeostatically regulated protein degradation pathway A stress-inducible protein catabolic pathway that promotes protein quality control by accelerating the degradation of misfolded ER membrane and cytosolic proteins, as well as native proteins. The pathway starts with the activation, by stress, of the Nma111p/Ynm3p serine protease, which cleaves the stress-induced hydrophilin Roq1p, resulting in the generation of a Roq1p cleavage product that selectively interacts with Ubr1p, an E3 ubiquitin ligase. Interaction with the Ubr1p type-1 substrate binding site reprograms the substrate specificity of this ubiquitin ligase resulting in the selective proteasome-mediated degradation of misfolded and native proteins. The pathway ends with degradation of the protein by the cytoplasmic proteasome. Currently, NMA111, ROQ1, UBR1, RAD6, and CDC48 are considered to be involved in this quality control pathway. got7fsn_ti SHRED pathway Note, although the SHRED pathway may contain some components in common with ER-associated protein degradation (ERAD) pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10 do not appear to be involved, and as such these pathways are currently considered to be distinct. ERAD pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M) and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by subsequent substrate ubiquitination and proteosome-mediated degradation. In contrast the SHRED pathway, although inducible by stress, targets diverse ER membrane and cytosolic proteins as well as numerous other native proteins in the absence of stress. In the SHRED pathway an Nma111p serine protease-mediated cleavage results in the generation of a Roq1p fragment that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. SHRED is also considered to be distinct from the endoplasmic reticulum unfolded protein response (GO:0030968), a process by which ER stress activates the ER membrane protein Ire1p, resulting in splicing of the HAC1 mRNA, followed by Hac1p-mediated up-regulation of UPR genes. Induction of SHRED does not require IRE1 or HAC1, and as such is currently considered to be distinct. krc 2018-06-07T16:16:43Z biological_process owl:Class
GO:0033554 biolink:NamedThing cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0005252 biolink:NamedThing open rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration. got7fsn_ti molecular_function owl:Class
GO:0005249 biolink:NamedThing voltage-gated potassium channel activity Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-sensitive potassium channel|voltage-dependent potassium channel activity|voltage gated potassium channel activity|voltage-gated potassium ion channel activity Reactome:R-HSA-1296127 molecular_function owl:Class
GO:0051877 biolink:NamedThing pigment granule aggregation in cell center The directed movement of dispersed pigment granules towards the center of the cell. got7fsn_ti biological_process owl:Class
GO:0051905 biolink:NamedThing establishment of pigment granule localization The directed movement of a pigment granule to a specific location. got7fsn_ti establishment of pigment granule localisation biological_process owl:Class
GO:0102275 biolink:NamedThing cysteine-S-conjugate N-malonyl transferase activity Catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate <=> coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate. got7fsn_ti MetaCyc:RXN-12534 molecular_function owl:Class
GO:0003401 biolink:NamedThing axis elongation The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure. got7fsn_ti elongation of an axis dph 2009-12-21T01:12:15Z biological_process owl:Class
GO:0047485 biolink:NamedThing protein N-terminus binding Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. got7fsn_ti amino-terminus binding|NH2-terminus binding|N-terminal binding|NH2-terminal binding|N-terminal end binding|amino-terminal binding molecular_function owl:Class
GO:0005515 biolink:NamedThing protein binding Binding to a protein. got7fsn_ti protein amino acid binding|glycoprotein binding GO:0045308|GO:0001948 molecular_function owl:Class
GO:0140582 biolink:NamedThing adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway A series of molecular signals initiated by cAMP binding to its receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. got7fsn_ti extracellular cAMP signaling pathway https://github.com/geneontology/go-ontology/issues/20487 pg 2021-01-18T19:30:30Z biological_process owl:Class
GO:0007189 biolink:NamedThing adenylate cyclase-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP). got7fsn_ti positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway|positive regulation of adenylate cyclase activity by G-protein signalling pathway|G-protein signalling, adenylate cyclase activating pathway|G-protein signaling, adenylate cyclase activating pathway|G protein signalling, adenylate cyclase activating pathway|G protein signaling, adenylate cyclase activating pathway|GPCR signaling pathway via activation of adenylate cyclase|G-protein signaling, adenylyl cyclase activating pathway|G protein signalling, adenylyl cyclase activating pathway|G protein signaling, adenylyl cyclase activating pathway|activation of adenylate cyclase activity by G-protein signaling pathway|GPCR signaling pathway via activation of adenylate cyclase activity|adenylate cyclase-activating GPCR signaling pathway|activation of adenylate cyclase activity involved in G-protein signaling|positive regulation of adenylate cyclase activity by G-protein signaling pathway|G-protein signalling, adenylyl cyclase activating pathway This term can be used to annotate ligands, receptors and G-proteins that lead to activation of adenylate cyclase activity within a signaling pathway. GO:0010579|GO:0010580 biological_process owl:Class
GO:0071595 biolink:NamedThing Nem1-Spo7 phosphatase complex A protein serine/threonine phosphatase complex that is involved in nuclear envelope organization, and contains proteins known in budding yeast as Nem1p and Spo7p. got7fsn_ti mah 2010-01-29T02:17:29Z cellular_component owl:Class
GO:0033802 biolink:NamedThing isoliquiritigenin 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoliquiritigenin = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase activity|chalcone OMT|CHMT KEGG_REACTION:R07242|RHEA:21608|MetaCyc:RXN-3501|EC:2.1.1.154 molecular_function owl:Class
GO:0061201 biolink:NamedThing clathrin-sculpted gamma-aminobutyric acid transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted gamma-aminobutyric acid transport vesicle. got7fsn_ti clathrin sculpted gamma-aminobutyric acid transport vesicle lumen|clathrin sculpted GABA transport vesicle lumen dph 2010-07-29T10:45:05Z cellular_component owl:Class
GO:0060205 biolink:NamedThing cytoplasmic vesicle lumen The volume enclosed by a cytoplasmic vesicle. got7fsn_ti cytoplasmic membrane-enclosed vesicle lumen|cytoplasmic membrane-bounded vesicle lumen cellular_component owl:Class
GO:0048256 biolink:NamedThing flap endonuclease activity Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. got7fsn_ti molecular_function owl:Class
GO:0004520 biolink:NamedThing endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. got7fsn_ti endonuclease G activity|DNA nicking activity Reactome:R-HSA-5690988|Reactome:R-HSA-6782224|Reactome:R-HSA-5693608|Reactome:R-HSA-5687464|Reactome:R-HSA-110359|Reactome:R-HSA-5686657|Reactome:R-HSA-6782204|Reactome:R-HSA-5693584|Reactome:R-HSA-5686440|Reactome:R-HSA-9023941 molecular_function owl:Class
GO:0031261 biolink:NamedThing DNA replication preinitiation complex A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present. got7fsn_ti pre-IC cellular_component owl:Class
GO:0032993 biolink:NamedThing protein-DNA complex A macromolecular complex containing both protein and DNA molecules. got7fsn_ti DNA-protein complex Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. cellular_component owl:Class
GO:0044736 biolink:NamedThing acid-sensing ion channel activity Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when an extracellular proton has been bound by the channel complex. got7fsn_ti ASIC activity jl 2012-11-06T16:36:37Z Reactome:R-HSA-2671885|Wikipedia:Acid-sensing_ion_channel molecular_function owl:Class
GO:0015280 biolink:NamedThing ligand-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti ASIC activity|epithelial sodium channel|amiloride-sensitive sodium channel activity|acid-sensing ion channel activity Reactome:R-HSA-2672334 molecular_function owl:Class
GO:0003423 biolink:NamedThing growth plate cartilage chondrocyte division The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate. got7fsn_ti dph 2009-12-22T09:55:51Z biological_process owl:Class
GO:0051301 biolink:NamedThing cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. got7fsn_ti Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. Wikipedia:Cell_division biological_process owl:Class
GO:0042073 biolink:NamedThing intraciliary transport The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins. got7fsn_ti intraflagellar transport involved in cilium organization|IFT|intraflagellar transport involved in microtubule-based flagellum organisation|intraflagellar transport Note that we deem cilium and microtubule-based flagellum to be equivalent. GO:0035734 Wikipedia:Intraflagellar_transport biological_process owl:Class
GO:0010970 biolink:NamedThing transport along microtubule The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity. got7fsn_ti movement along microtubule|establishment of localization by movement along microtubule|microtubule-based transport tb 2009-05-27T10:56:08Z biological_process owl:Class
GO:0061388 biolink:NamedThing regulation of rate of cell growth Any process that modulates the rate of cell growth. got7fsn_ti dph 2011-07-14T10:18:06Z biological_process owl:Class
GO:0001558 biolink:NamedThing regulation of cell growth Any process that modulates the frequency, rate, extent or direction of cell growth. got7fsn_ti biological_process owl:Class
GO:0072663 biolink:NamedThing establishment of protein localization to peroxisome The directed movement of a protein to a specific location in a peroxisome. got7fsn_ti establishment of protein localisation to peroxisome mah 2011-02-14T02:50:36Z biological_process owl:Class
GO:0072594 biolink:NamedThing establishment of protein localization to organelle The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. got7fsn_ti establishment of protein localisation to organelle mah 2011-02-14T01:56:51Z biological_process owl:Class
GO:0031578 biolink:NamedThing mitotic spindle orientation checkpoint signaling A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected. got7fsn_ti SPOC|signal transduction involved in mitotic cell cycle spindle orientation checkpoint|SOC|mitotic cell cycle spindle orientation checkpoint|spindle position checkpoint|mitotic spindle orientation checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072483 biological_process owl:Class
GO:0001100 biolink:NamedThing negative regulation of exit from mitosis Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). got7fsn_ti downregulation of exit from mitosis|down regulation of exit from mitosis|inhibition of exit from mitosis|down-regulation of exit from mitosis biological_process owl:Class
GO:0106335 biolink:NamedThing tRNA (carboxymethyluridine(34)-5-O)-methyltransferase activity Catalysis of the reaction: carboxymethyluridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine. got7fsn_ti hjd 2020-10-27T21:34:30Z RHEA:43208|EC:2.1.1.229 molecular_function owl:Class
GO:0060718 biolink:NamedThing chorionic trophoblast cell differentiation The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer. got7fsn_ti dph 2009-06-11T02:48:27Z biological_process owl:Class
GO:0030381 biolink:NamedThing chorion-containing eggshell pattern formation The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects. got7fsn_ti biological_process owl:Class
GO:0034752 biolink:NamedThing cytosolic aryl hydrocarbon receptor complex An aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP. got7fsn_ti cytosolic AhR complex|cytosolic AHRC|9S-cytosolic aryl hydrocarbon (Ah) receptor non-ligand activated complex cellular_component owl:Class
GO:0034751 biolink:NamedThing aryl hydrocarbon receptor complex A protein complex that acts as an aryl hydrocarbon (Ah) receptor. Cytosolic and nuclear Ah receptor complexes have different subunit composition, but both contain the ligand-binding subunit AhR. got7fsn_ti AhR complex|AHRC cellular_component owl:Class
GO:0005024 biolink:NamedThing transforming growth factor beta-activated receptor activity Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. got7fsn_ti TGFbeta-activated receptor activity|TGF-beta receptor activity|transforming growth factor beta receptor activity|TGFbeta receptor activity|TGFbetaR Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class
GO:0004675 biolink:NamedThing transmembrane receptor protein serine/threonine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. got7fsn_ti receptor protein serine/threonine kinase activity|receptor serine/threonine protein kinase activity EC:2.7.11.30|Reactome:R-HSA-198732|Reactome:R-HSA-170868|Reactome:R-HSA-201476|MetaCyc:2.7.11.30-RXN|RHEA:18673 molecular_function owl:Class
GO:0047563 biolink:NamedThing 3-hydroxybenzoate 2-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + AH(2) + O(2) = 2,3-dihydroxybenzoate + A + H(2)O. got7fsn_ti 3-hydroxybenzoate,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)|3-hydroxybenzoate 2-hydroxylase activity|3-HBA-2-hydroxylase activity KEGG_REACTION:R01508|RHEA:14193|MetaCyc:3-HYDROXYBENZOATE-2-MONOOXYGENASE-RXN|EC:1.14.99.23 molecular_function owl:Class
GO:0031051 biolink:NamedThing scnRNA processing Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome. got7fsn_ti scnRNA production biological_process owl:Class
GO:0031050 biolink:NamedThing dsRNA processing Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function. got7fsn_ti dsRNA fragmentation|double-stranded RNA fragmentation biological_process owl:Class
GO:0019133 biolink:NamedThing choline monooxygenase activity Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O. got7fsn_ti choline,reduced-ferredoxin:oxygen oxidoreductase activity RHEA:17769|EC:1.14.15.7|MetaCyc:RXN1F-357 molecular_function owl:Class
GO:0016713 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen EC:1.14.15.- molecular_function owl:Class
GO:0031776 biolink:NamedThing melanin-concentrating hormone receptor binding Binding to a melanin-concentrating hormone receptor. got7fsn_ti melanin-concentrating hormone receptor ligand molecular_function owl:Class
GO:0071855 biolink:NamedThing neuropeptide receptor binding Binding to a neuropeptide receptor. got7fsn_ti mah 2010-09-10T03:21:43Z molecular_function owl:Class
GO:0002774 biolink:NamedThing Fc receptor mediated inhibitory signaling pathway A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. got7fsn_ti Fc-receptor mediated inhibitory signaling pathway|Fc receptor mediated inhibitory signalling pathway biological_process owl:Class
GO:0002767 biolink:NamedThing immune response-inhibiting cell surface receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response. got7fsn_ti immune response-inhibiting cell surface receptor signalling pathway biological_process owl:Class
GO:0032797 biolink:NamedThing SMN complex A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus. got7fsn_ti survival motor neuron complex|SMN core complex Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'. cellular_component owl:Class
GO:0120114 biolink:NamedThing Sm-like protein family complex A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles. got7fsn_ti krc 2017-11-06T18:46:43Z cellular_component owl:Class
GO:0046960 biolink:NamedThing sensitization An increased in a behavioral response to a repeated stimulus. For example, a shock to the tail of the marine snail Aplysia, to which the snail responds by withdrawing its gill, will result in increased gill withdrawal the next time the skin is touched. got7fsn_ti Wikipedia:Sensitization biological_process owl:Class
GO:0046958 biolink:NamedThing nonassociative learning A simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus. There is no association of one type of stimulus with another, rather it is a generalized response to the environment. got7fsn_ti unconditional response biological_process owl:Class
GO:0140511 biolink:NamedThing mitotic nuclear bridge stalk Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes. got7fsn_ti pg 2020-09-07T10:06:23Z cellular_component owl:Class
GO:0016667 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on sulfur group of donors, other acceptors|oxidoreductase activity, acting on sulphur group of donors EC:1.8.-.-|Reactome:R-HSA-2213240 molecular_function owl:Class
GO:0097531 biolink:NamedThing mast cell migration The movement of a mast cell within or between different tissues and organs of the body. got7fsn_ti pr 2013-11-11T14:01:41Z biological_process owl:Class
GO:0097529 biolink:NamedThing myeloid leukocyte migration The movement of a myeloid leukocyte within or between different tissues and organs of the body. got7fsn_ti pr 2013-11-11T13:59:43Z biological_process owl:Class
GO:0047623 biolink:NamedThing adenosine-phosphate deaminase activity Catalysis of the reaction: an adenosine-phosphate + H20 = an inosine phosphate + NH3. Catalyzes the deamination of AMP, ADP or ATP. got7fsn_ti adenosine-phosphate aminohydrolase activity|adenine nucleotide deaminase activity|adenosine (phosphate) deaminase activity Consider instead annotating to one of the more specific terms: AMP deaminase activity ; GO:0003876, ADP deaminase activity ; GO:0047629, or ATP deaminase activity ; GO:0047692. MetaCyc:ADENOSINE-PHOSPHATE-DEAMINASE-RXN|EC:3.5.4.17 molecular_function owl:Class
GO:0016814 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. got7fsn_ti EC:3.5.4.- molecular_function owl:Class
GO:0047827 biolink:NamedThing D-lysopine dehydrogenase activity Catalysis of the reaction: D-lysopine + H(2)O + NADP(+) = L-lysine + H(+) + NADPH + pyruvate. got7fsn_ti 2-N-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|N2-(D-1-carboxyethyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|lysopine dehydrogenase activity|D(+)-lysopine dehydrogenase activity|D-lysopine synthase activity RHEA:17625|EC:1.5.1.16|KEGG_REACTION:R00452|MetaCyc:D-LYSOPINE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0016646 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti EC:1.5.1.- molecular_function owl:Class
GO:0002144 biolink:NamedThing cytosolic tRNA wobble base thiouridylase complex A complex of two proteins involved in the thiolation of uridine 34 (U34) of tRNAs decoding two-family box triplets. got7fsn_ti tRNA thiouridylase|Cut1-Cut2 complex hjd 2009-05-08T02:32:55Z cellular_component owl:Class
GO:0030217 biolink:NamedThing T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. got7fsn_ti T cell development|T lymphocyte differentiation|T-lymphocyte differentiation|T-cell differentiation Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. GO:0042112|GO:0046652 biological_process owl:Class
GO:0042110 biolink:NamedThing T cell activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti T-cell activation|T-lymphocyte activation|T lymphocyte activation biological_process owl:Class
GO:0072119 biolink:NamedThing head kidney structural organization The process that contributes to the act of creating the structural organization of the head kidney. This process pertains to the physical shaping of a rudimentary structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. got7fsn_ti head kidney structural organisation mah 2010-02-22T11:22:12Z biological_process owl:Class
GO:0072118 biolink:NamedThing pronephros structural organization The process that contributes to the act of creating the structural organization of the pronephros. This process pertains to the physical shaping of a rudimentary structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. got7fsn_ti pronephric kidney structural organization|pronephros structural organisation mah 2010-02-22T11:21:38Z biological_process owl:Class
GO:0045701 biolink:NamedThing negative regulation of spermatid nuclear differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of spermatid nuclear differentiation. got7fsn_ti inhibition of spermatid nuclear differentiation|down-regulation of spermatid nuclear differentiation|down regulation of spermatid nuclear differentiation|downregulation of spermatid nuclear differentiation biological_process owl:Class
GO:0045596 biolink:NamedThing negative regulation of cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation. got7fsn_ti down regulation of cell differentiation|downregulation of cell differentiation|down-regulation of cell differentiation|inhibition of cell differentiation biological_process owl:Class
GO:0002209 biolink:NamedThing behavioral defense response A behavioral response seeking to protect an organism from an a perceived external threat to that organism. got7fsn_ti behavioural defense response biological_process owl:Class
GO:0006952 biolink:NamedThing defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. got7fsn_ti defense/immunity protein activity|defence response|antimicrobial peptide activity|physiological defense response GO:0002217|GO:0042829 biological_process owl:Class
GO:0022013 biolink:NamedThing pallium cell proliferation in forebrain The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population. got7fsn_ti biological_process owl:Class
GO:0021846 biolink:NamedThing cell proliferation in forebrain The creation of greater cell numbers in the forebrain due to cell division of progenitor cells. got7fsn_ti biological_process owl:Class
GO:0018292 biolink:NamedThing molybdenum incorporation via L-cysteinyl molybdopterin The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin. got7fsn_ti RESID:AA0142 biological_process owl:Class
GO:0018315 biolink:NamedThing molybdenum incorporation into molybdenum-molybdopterin complex The incorporation of molybdenum into a molybdenum-molybdopterin complex. got7fsn_ti molybdenum incorporation into metallo-pterin complex GO:0042041 biological_process owl:Class
GO:0004750 biolink:NamedThing ribulose-phosphate 3-epimerase activity Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. got7fsn_ti erythrose-4-phosphate isomerase activity|ribulose 5-phosphate 3-epimerase activity|pentose-5-phosphate 3-epimerase activity|D-ribulose-5-P 3-epimerase activity|D-xylulose-5-phosphate 3-epimerase activity|xylulose phosphate 3-epimerase activity|D-ribulose-5-phosphate epimerase activity|erythrose-4-phosphate epimerase activity|phosphoketopentose 3-epimerase activity|D-ribulose phosphate-3-epimerase activity|D-ribulose 5-phosphate epimerase activity|phosphoketopentose epimerase activity|D-ribulose-5-phosphate 3-epimerase activity|phosphoribulose epimerase activity Reactome:R-HSA-71303|Reactome:R-HSA-199803|KEGG_REACTION:R01529|RHEA:13677|MetaCyc:RIBULP3EPIM-RXN|EC:5.1.3.1 molecular_function owl:Class
GO:0016857 biolink:NamedThing racemase and epimerase activity, acting on carbohydrates and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. got7fsn_ti Reactome:R-HSA-6787677|EC:5.1.3.- molecular_function owl:Class
GO:0015024 biolink:NamedThing glucuronate-2-sulfatase activity Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. got7fsn_ti glucurono-2-sulfatase activity|polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity|glucuronate-2-sulphatase activity|chondro-2-sulfatase activity MetaCyc:3.1.6.18-RXN|EC:3.1.6.18 molecular_function owl:Class
GO:0008484 biolink:NamedThing sulfuric ester hydrolase activity Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. got7fsn_ti sulfatase activity|sulphuric ester hydrolase activity MetaCyc:ARYLSULFAT-RXN|EC:3.1.6.- molecular_function owl:Class
GO:0042447 biolink:NamedThing hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. got7fsn_ti hormone breakdown|hormone catabolism|hormone degradation biological_process owl:Class
GO:0034115 biolink:NamedThing negative regulation of heterotypic cell-cell adhesion Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion. got7fsn_ti biological_process owl:Class
GO:0070587 biolink:NamedThing regulation of cell-cell adhesion involved in gastrulation Any process that modulates the frequency, rate, or extent of attachment of a cell to another cell affecting gastrulation. got7fsn_ti mah 2009-04-24T02:51:07Z biological_process owl:Class
GO:0047995 biolink:NamedThing hydroxyphenylpyruvate reductase activity Catalysis of the reaction: 3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH. got7fsn_ti HPRP|4-hydroxyphenyllactate:NAD+ oxidoreductase activity EC:1.1.1.237|RHEA:10780|MetaCyc:HYDROXYPHENYLPYRUVATE-REDUCTASE-RXN molecular_function owl:Class
GO:0044649 biolink:NamedThing envenomation resulting in cytolysis in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism. got7fsn_ti jl 2012-07-11T02:13:38Z biological_process owl:Class
GO:0047676 biolink:NamedThing arachidonate-CoA ligase activity Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H(+). got7fsn_ti arachidonate:CoA ligase (AMP-forming)|arachidonoyl-CoA synthetase activity RHEA:19713|MetaCyc:ARACHIDONATE--COA-LIGASE-RXN|KEGG_REACTION:R01598|EC:6.2.1.15 molecular_function owl:Class
GO:0016405 biolink:NamedThing CoA-ligase activity Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. got7fsn_ti Reactome:R-HSA-177157|Reactome:R-HSA-159443|Reactome:R-HSA-6798345|Reactome:R-HSA-159567 molecular_function owl:Class
GO:0075313 biolink:NamedThing basidium development The process that leads to the development of basidium, a small, specialized club-shaped structure typically bearing four basidiospores at the tips of minute projections. The basidium is unique to Basidiomycetes and distinguishes them from other kinds of fungi. got7fsn_ti Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked. biological_process owl:Class
GO:0075259 biolink:NamedThing spore-bearing structure development The process whose specific outcome is the progression of a spore-bearing structure over time, from its formation to the mature structure. A spore-bearing structure is an anatomical structure that produces new spores. got7fsn_ti sporangium development|sporophore development|fruiting structure development|spore-bearing organ development biological_process owl:Class
GO:0005146 biolink:NamedThing leukemia inhibitory factor receptor binding Binding to an leukemia inhibitory factor receptor. got7fsn_ti leukemia inhibitory factor|leukemia inhibitory factor receptor ligand molecular_function owl:Class
GO:0005126 biolink:NamedThing cytokine receptor binding Binding to a cytokine receptor. got7fsn_ti hematopoietin/interferon-class (D200-domain) cytokine receptor binding|hematopoietin/interferon-class (D200-domain) cytokine receptor ligand molecular_function owl:Class
GO:0036313 biolink:NamedThing phosphatidylinositol 3-kinase catalytic subunit binding Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. got7fsn_ti p110 binding|PI3K catalytic subunit binding bf 2012-08-16T10:58:45Z molecular_function owl:Class
GO:0009757 biolink:NamedThing hexose mediated signaling A series of molecular signals mediated by the detection of hexose. got7fsn_ti hexose mediated signalling biological_process owl:Class
GO:0010182 biolink:NamedThing sugar mediated signaling pathway The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes. got7fsn_ti sugar mediated signalling biological_process owl:Class
GO:0018069 biolink:NamedThing peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase. got7fsn_ti RESID:AA0149 biological_process owl:Class
GO:0018149 biolink:NamedThing peptide cross-linking The formation of a covalent cross-link between or within protein chains. got7fsn_ti biological_process owl:Class
GO:0048653 biolink:NamedThing anther development The process whose specific outcome is the progression of the anther over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0034214 biolink:NamedThing protein hexamerization The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits. got7fsn_ti protein hexamer biosynthesis|protein hexamer assembly|protein hexamer biosynthetic process|protein hexamer formation biological_process owl:Class
GO:0051259 biolink:NamedThing protein complex oligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. got7fsn_ti protein oligomer biosynthesis|protein multimerization|protein oligomer formation|protein oligomer biosynthetic process|protein oligomer assembly|protein oligomerization bf 2011-04-05T09:57:49Z GO:0035786 biological_process owl:Class
GO:0051220 biolink:NamedThing cytoplasmic sequestering of protein The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell. got7fsn_ti storage of protein in cytoplasm|maintenance of protein location in cytoplasm|cytoplasmic storage of protein|retention of protein in cytoplasm|sequestration of protein in cytoplasm|cytoplasmic retention of protein|cytoplasmic sequestration of protein|sequestering of protein in cytoplasm biological_process owl:Class
GO:0045185 biolink:NamedThing maintenance of protein location Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away. got7fsn_ti protein retention|protein sequestering|maintenance of protein localization|active protein retrieval biological_process owl:Class
GO:0102553 biolink:NamedThing lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein) Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [pyruvate dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. got7fsn_ti EC:2.8.1.8|MetaCyc:RXN-14957 molecular_function owl:Class
GO:0031323 biolink:NamedThing regulation of cellular metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. got7fsn_ti regulation of cellular metabolism biological_process owl:Class
GO:0009570 biolink:NamedThing chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis. got7fsn_ti cellular_component owl:Class
GO:0009532 biolink:NamedThing plastid stroma The proteinaceous ground substance of plastids. got7fsn_ti cellular_component owl:Class
GO:0061291 biolink:NamedThing canonical Wnt signaling pathway involved in ureteric bud branching The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the branching of the ureteric bud. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. got7fsn_ti canonical Wnt receptor signalling pathway involved in ureteric bud branching|canonical Wnt receptor signaling pathway involved in ureteric bud branching dph 2010-09-03T12:15:19Z biological_process owl:Class
GO:0061290 biolink:NamedThing canonical Wnt signaling pathway involved in metanephric kidney development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contribute to the progression of the metanephric kidney over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. got7fsn_ti canonical Wnt receptor signaling pathway involved in metanephric kidney development|canonical Wnt-activated signaling pathway involved in metanephric kidney development|canonical Wnt receptor signalling pathway involved in metanephric kidney development dph 2010-09-03T12:06:10Z biological_process owl:Class
GO:0033874 biolink:NamedThing scymnol sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H(+). got7fsn_ti RHEA:15477|EC:2.8.2.32|KEGG_REACTION:R07798|MetaCyc:2.8.2.32-RXN molecular_function owl:Class
GO:0019105 biolink:NamedThing N-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0042311 biolink:NamedThing vasodilation An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. got7fsn_ti positive regulation of blood vessel size|vasodilatation https://github.com/geneontology/go-ontology/issues/12253 GO:0045909 Wikipedia:Vasodilation biological_process owl:Class
GO:0097746 biolink:NamedThing blood vessel diameter maintenance Any process that modulates the diameter of blood vessels. got7fsn_ti regulation of vasodilation|blood vessel diameter homeostasis|regulation of blood vessel diameter|regulation of vasodilatation|regulation of blood vessel size https://github.com/geneontology/go-ontology/issues/12253 pr 2016-11-24T15:45:05Z GO:0042312|GO:0050880 biological_process owl:Class
GO:0008106 biolink:NamedThing alcohol dehydrogenase (NADP+) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+. got7fsn_ti NADP-aldehyde reductase activity|alcohol:NADP dehydrogenase activity|aldehyde reductase (NADPH) activity|aldehyde reductase (NADPH2) activity MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN|RHEA:15937|EC:1.1.1.2 molecular_function owl:Class
GO:0004033 biolink:NamedThing aldo-keto reductase (NADP) activity Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+. got7fsn_ti aldo-keto reductase activity|aldo-keto reductase (NADP+) activity|NADPH-dependent aldo-keto reductase activity|alcohol dehydrogenase (NADP+) activity Reactome:R-HSA-193800|Reactome:R-HSA-5692232|Reactome:R-HSA-193821|Reactome:R-HSA-9027598|Reactome:R-HSA-9027531|Reactome:R-HSA-5423637|Reactome:R-HSA-192067|Reactome:R-HSA-9027600|Reactome:R-HSA-193746|Reactome:R-HSA-192033|Reactome:R-HSA-193781|Reactome:R-HSA-192160|Reactome:R-HSA-193758|Reactome:R-HSA-2855252|Reactome:R-HSA-192036|Reactome:R-HSA-193755|Reactome:R-HSA-193824|Reactome:R-HSA-193841|Reactome:R-HSA-198845|Reactome:R-HSA-9027562 molecular_function owl:Class
GO:0038196 biolink:NamedThing type III interferon signaling pathway A series of molecular signals initiated by the binding of a type III interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far. got7fsn_ti interferon lambda signaling pathway|type III interferon-activated signaling pathway bf 2013-11-27T14:25:49Z biological_process owl:Class
GO:0048513 biolink:NamedThing animal organ development Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti development of an organ|organogenesis Wikipedia:Organogenesis biological_process owl:Class
GO:0097493 biolink:NamedThing structural molecule activity conferring elasticity The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling. got7fsn_ti pr 2013-07-26T09:47:26Z molecular_function owl:Class
GO:0005198 biolink:NamedThing structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell. got7fsn_ti molecular_function owl:Class
GO:0000804 biolink:NamedThing W chromosome The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females. got7fsn_ti Wikipedia:ZW_sex-determination_system cellular_component owl:Class
GO:0070456 biolink:NamedThing galactose-1-phosphate phosphatase activity Catalysis of the reaction: galactose-1-phosphate + H2O = galactose + phosphate. got7fsn_ti molecular_function owl:Class
GO:0050308 biolink:NamedThing sugar-phosphatase activity Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate. got7fsn_ti sugar-phosphate phosphohydrolase activity|sugar-phosphate phosphatase activity MetaCyc:SUGAR-PHOSPHATASE-RXN|KEGG_REACTION:R00804|EC:3.1.3.23 molecular_function owl:Class
GO:0071559 biolink:NamedThing response to transforming growth factor beta Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. got7fsn_ti response to TGF-beta stimulus|response to TGFbeta stimulus|response to transforming growth factor beta stimulus mah 2010-01-20T11:49:59Z biological_process owl:Class
GO:0005684 biolink:NamedThing U2-type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends. got7fsn_ti GT-AG spliceosome|major spliceosomal complex|major (U2-type) spliceosomal complex A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP. cellular_component owl:Class
GO:0005681 biolink:NamedThing spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. got7fsn_ti spliceosome complex|spliceosome Wikipedia:Spliceosome cellular_component owl:Class
GO:0002128 biolink:NamedThing tRNA nucleoside ribose methylation The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position. got7fsn_ti biological_process owl:Class
GO:0030488 biolink:NamedThing tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. got7fsn_ti biological_process owl:Class
GO:0004508 biolink:NamedThing steroid 17-alpha-monooxygenase activity Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. got7fsn_ti steroid 17alpha-hydroxylase activity|cytochrome P450 CYP17|steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)|steroid 17-alpha-hydroxylase activity|steroid 17alpha-monooxygenase activity|17alpha-hydroxylase-C17,20 lyase activity|steroid 17-alpha-hydroxylase/17,20 lyase activity|cytochrome p450 XVIIA1 activity|cytochrome P45017alpha|steroid 17-alpha-hydroxylase-C17-20 lyase activity|steroid 17alphahydroxylase/17,20 lyase activity|cytochrome P-450 (P-45017alpha,lyase) Reactome:R-HSA-193072|Reactome:R-HSA-193099|MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN|Reactome:R-HSA-9035954|Reactome:R-HSA-5601843|Reactome:R-HSA-193070|Reactome:R-HSA-193068|EC:1.14.14.19|Reactome:R-HSA-9035956 molecular_function owl:Class
GO:0008395 biolink:NamedThing steroid hydroxylase activity Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. got7fsn_ti cytochrome P450 CYP2G1|olfactory-specific steroid hydroxylase activity GO:0008394 Reactome:R-HSA-193060|Reactome:R-HSA-6785245|Reactome:R-HSA-193497|Reactome:R-HSA-193965|Reactome:R-HSA-193713|Reactome:R-HSA-193460|Reactome:R-HSA-5602170|Reactome:R-HSA-193393|Reactome:R-HSA-5601849|Reactome:R-HSA-192042|Reactome:R-HSA-193737|Reactome:R-HSA-6785244|Reactome:R-HSA-192123|Reactome:R-HSA-193780|Reactome:R-HSA-192054|Reactome:R-HSA-193995|RHEA:43836|Reactome:R-HSA-193787|Reactome:R-HSA-191999|Reactome:R-HSA-9035960|Reactome:R-HSA-193143|Reactome:R-HSA-193719|Reactome:R-HSA-193792|Reactome:R-HSA-191983 molecular_function owl:Class
GO:0097632 biolink:NamedThing extrinsic component of phagophore assembly site membrane The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to phagophore assembly site membrane|extrinsic component of pre-autophagosomal structure membrane|phagophore assembly site peripheral membrane cellular_component owl:Class
GO:0031312 biolink:NamedThing extrinsic component of organelle membrane The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to organelle membrane cellular_component owl:Class
GO:0006955 biolink:NamedThing immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. got7fsn_ti biological_process owl:Class
GO:0050961 biolink:NamedThing detection of temperature stimulus involved in sensory perception The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception. got7fsn_ti sensory detection of temperature stimulus|sensory perception, sensory transduction of heat stimulus|sensory perception, sensory detection of thermal stimulus|sensory perception, sensory transduction of temperature stimulus|sensory transduction of temperature stimulus|sensory detection of heat stimulus during sensory perception|sensory perception, sensory detection of heat stimulus|sensory transduction of thermal stimulus during sensory perception|sensory detection of thermal stimulus during sensory perception|sensory transduction of temperature stimulus during sensory perception|sensory transduction of heat stimulus during sensory perception|sensory detection of temperature stimulus during sensory perception|sensory perception, sensory detection of temperature stimulus|sensory perception, sensory transduction of thermal stimulus biological_process owl:Class
GO:0050906 biolink:NamedThing detection of stimulus involved in sensory perception The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal. got7fsn_ti sensory perception, sensory transduction of stimulus|sensory detection of stimulus|sensory perception, stimulus detection|sensory transduction Wikipedia:Transduction_(physiology) biological_process owl:Class
GO:0061223 biolink:NamedThing mesonephric mesenchymal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the mesonephros as it progresses from its formation to the mature state. got7fsn_ti dph 2010-08-19T01:21:48Z biological_process owl:Class
GO:0061208 biolink:NamedThing cell differentiation involved in mesonephros development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephros as it progresses from its formation to the mature state. got7fsn_ti dph 2010-08-17T03:21:23Z biological_process owl:Class
GO:0061198 biolink:NamedThing fungiform papilla formation The developmental process pertaining to the initial formation of a spongiform papilla from unspecified parts. The fungiform papilla is a mushroom-shaped papilla of the tongue. got7fsn_ti dph 2010-07-27T12:29:03Z biological_process owl:Class
GO:0048871 biolink:NamedThing multicellular organismal homeostasis Any process involved in the maintenance of an internal steady state at the level of the multicellular organism. got7fsn_ti biological_process owl:Class
GO:0042592 biolink:NamedThing homeostatic process Any biological process involved in the maintenance of an internal steady state. got7fsn_ti homeostasis|regulation of homeostatic process|positive regulation of homeostatic process|negative regulation of homeostatic process|inhibition of homeostatic process|activation of homeostatic process GO:0032846|GO:0032844|GO:0032845 biological_process owl:Class
GO:0010366 biolink:NamedThing negative regulation of ethylene biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process. got7fsn_ti biological_process owl:Class
GO:0031336 biolink:NamedThing negative regulation of sulfur amino acid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. got7fsn_ti down-regulation of sulfur amino acid metabolic process|downregulation of sulfur amino acid metabolic process|negative regulation of sulfur amino acid metabolism|down regulation of sulfur amino acid metabolic process|inhibition of sulfur amino acid metabolic process biological_process owl:Class
GO:0017042 biolink:NamedThing glycosylceramidase activity Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. got7fsn_ti phloretin-glucosidase activity|lactase-phlorizin hydrolase|cerebrosidase activity|phlorizin hydrolase activity|glycosyl-N-acylsphingosine glycohydrolase activity|phloridzin glucosidase activity|phloridzin beta-glucosidase activity|glycosyl ceramide glycosylhydrolase activity EC:3.2.1.62|MetaCyc:GLYCOSYLCERAMIDASE-RXN molecular_function owl:Class
GO:0060454 biolink:NamedThing positive regulation of gastric acid secretion Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. got7fsn_ti biological_process owl:Class
GO:0061355 biolink:NamedThing Wnt protein secretion The controlled release of a Wnt protein from a cell. got7fsn_ti dph 2010-10-08T01:07:48Z biological_process owl:Class
GO:0009306 biolink:NamedThing protein secretion The controlled release of proteins from a cell. got7fsn_ti protein secretion resulting in cell fate commitment|glycoprotein secretion|protein secretion during cell fate commitment GO:0045731|GO:0045166 biological_process owl:Class
GO:1990185 biolink:NamedThing regulation of lymphatic vascular permeability Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid. got7fsn_ti sl 2013-09-11T15:36:22Z biological_process owl:Class
GO:2000874 biolink:NamedThing regulation of glyoxylate cycle Any process that modulates the frequency, rate or extent of glyoxylate cycle. got7fsn_ti regulation of glyoxylate bypass bf 2011-07-27T01:27:10Z biological_process owl:Class
GO:0050519 biolink:NamedThing holo-citrate lyase synthase activity Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase. got7fsn_ti CitX|2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase activity|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity|2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase activity|holo-ACP synthase activity RHEA:16333|MetaCyc:2.7.7.61-RXN|EC:2.7.7.61 molecular_function owl:Class
GO:0016779 biolink:NamedThing nucleotidyltransferase activity Catalysis of the transfer of a nucleotidyl group to a reactant. got7fsn_ti Reactome:R-HSA-6782434|EC:2.7.7.- molecular_function owl:Class
GO:1990883 biolink:NamedThing rRNA cytidine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA. got7fsn_ti al 2015-10-28T13:27:35Z molecular_function owl:Class
GO:0008080 biolink:NamedThing N-acetyltransferase activity Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. got7fsn_ti Reactome:R-HSA-2473152|Reactome:R-HSA-9636560|Reactome:R-HSA-6790987|Reactome:R-HSA-2468039 molecular_function owl:Class
GO:0009896 biolink:NamedThing positive regulation of catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. got7fsn_ti positive regulation of breakdown|activation of catabolic process|stimulation of catabolic process|up regulation of catabolic process|positive regulation of catabolism|up-regulation of catabolic process|positive regulation of degradation|upregulation of catabolic process biological_process owl:Class
GO:0009893 biolink:NamedThing positive regulation of metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. got7fsn_ti up-regulation of organismal metabolic process|positive regulation of multicellular organismal metabolic process|positive regulation of organismal metabolism|activation of metabolic process|stimulation of organismal metabolic process|upregulation of metabolic process|positive regulation of metabolism|up-regulation of metabolic process|up regulation of metabolic process|stimulation of metabolic process GO:0044253 biological_process owl:Class
GO:0030982 biolink:NamedThing adventurous gliding motility A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime. got7fsn_ti adventurous gliding movement biological_process owl:Class
GO:0071976 biolink:NamedThing cell gliding Cell motility that results in the smooth movement of a cell along a solid surface. got7fsn_ti cell gliding motility mah 2010-10-21T02:33:24Z biological_process owl:Class
GO:0052869 biolink:NamedThing arachidonic acid omega-hydroxylase activity Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid. got7fsn_ti arachidonic acid hydroxylase activity|arachidonic acid:oxygen 1-oxidoreductase activity ai 2012-01-30T03:05:27Z KEGG_REACTION:R07041|EC:1.14.15.3 molecular_function owl:Class
GO:0002046 biolink:NamedThing opsin binding Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. got7fsn_ti metarhodopsin binding GO:0016030 molecular_function owl:Class
GO:0019139 biolink:NamedThing cytokinin dehydrogenase activity Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. got7fsn_ti N6-dimethylallyladenine:acceptor oxidoreductase activity|6-N-dimethylallyladenine:acceptor oxidoreductase activity|cytokinin oxidase activity|N6-dimethylallyladenine:(acceptor) oxidoreductase activity GO:0046420 EC:1.5.99.12|RHEA:13625|MetaCyc:PWY-2841|MetaCyc:1.5.99.12-RXN molecular_function owl:Class
GO:0016645 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the CH-NH group of donors, other acceptors EC:1.5.-.- molecular_function owl:Class
GO:0052076 biolink:NamedThing induction by symbiont of host ethylene-mediated defense response Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti up-regulation by symbiont of host ethylene-mediated defense response|positive regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction|stimulation by symbiont of host ethylene-mediated defense response|positive regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction|up regulation by symbiont of host ethylene-mediated defense response|positive regulation by symbiont of host ethylene-mediated defense response|activation by symbiont of host ethylene-mediated defense response|upregulation by symbiont of host ethylene-mediated defense response|positive regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway GO:0052269|GO:0052274|GO:0052071 biological_process owl:Class
GO:0052028 biolink:NamedThing induction by symbiont of host signal transduction pathway Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti stimulation by symbiont of host signal transduction pathway|up regulation by symbiont of host signal transduction pathway|upregulation by symbiont of host signal transduction pathway|up-regulation by symbiont of host signal transduction pathway|activation by symbiont of host signal transduction pathway|positive regulation of signal transduction in other organism|positive regulation by organism of signal transduction in other organism involved in symbiotic interaction|positive regulation by symbiont of host signal transduction pathway GO:0052526|GO:0044502 biological_process owl:Class
GO:0102941 biolink:NamedThing 3,5-dihydroxyanisole O-methyltransferase activity Catalysis of the reaction: 3,5-dihydroxyanisole + S-adenosyl-L-methionine = H+ + 3,5-dimethoxyphenol + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-9021 molecular_function owl:Class
GO:0047043 biolink:NamedThing 3-alpha-hydroxycholanate dehydrogenase activity Catalysis of the reaction: lithocholate + NAD(+) = 3-oxo-5beta-cholanate + H(+) + NADH. got7fsn_ti alpha-hydroxy-cholanate dehydrogenase activity|3alpha-hydroxycholanate dehydrogenase activity|3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase activity MetaCyc:1.1.1.52-RXN|KEGG_REACTION:R04139|EC:1.1.1.52|RHEA:19585 molecular_function owl:Class
GO:0021506 biolink:NamedThing anterior neuropore closure The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete. got7fsn_ti biological_process owl:Class
GO:0016331 biolink:NamedThing morphogenesis of embryonic epithelium The process in which the anatomical structures of embryonic epithelia are generated and organized. got7fsn_ti biological_process owl:Class
GO:0016926 biolink:NamedThing protein desumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. got7fsn_ti protein desumolation|desumoylation GO:0016928 biological_process owl:Class
GO:0070646 biolink:NamedThing protein modification by small protein removal A protein modification process in which one or more covalently attached groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are removed from a target protein. got7fsn_ti mah 2009-05-11T01:58:15Z biological_process owl:Class
GO:0036220 biolink:NamedThing ITP diphosphatase activity Catalysis of the reaction: ITP + H2O = IMP + diphosphate. got7fsn_ti inosine-5'-triphosphate pyrophosphohydrolase activity bf 2012-05-08T01:47:59Z KEGG_REACTION:R00720|Reactome:R-HSA-2509827|RHEA:29399|MetaCyc:RXN0-6382 molecular_function owl:Class
GO:0047429 biolink:NamedThing nucleoside-triphosphate diphosphatase activity Catalysis of the reaction: H2O + a nucleoside triphosphate = diphosphate + a nucleotide. got7fsn_ti nucleoside-triphosphate pyrophosphatase activity|nucleoside-triphosphate diphosphohydrolase activity EC:3.6.1.9|MetaCyc:3.6.1.19-RXN molecular_function owl:Class
GO:0032176 biolink:NamedThing split septin rings A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well. got7fsn_ti cellular_component owl:Class
GO:0032156 biolink:NamedThing septin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes. got7fsn_ti cellular_component owl:Class
GO:0060777 biolink:NamedThing compound leaf morphogenesis The leaf morphogenesis process that results in the shaping of a compound leaf. A compound leaf is a leaf having two or more distinct leaflets that are evident as such from early in development. got7fsn_ti dph 2009-07-25T07:12:30Z biological_process owl:Class
GO:0009965 biolink:NamedThing leaf morphogenesis The process in which the anatomical structures of the leaf are generated and organized. got7fsn_ti biological_process owl:Class
GO:0009231 biolink:NamedThing riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). got7fsn_ti vitamin G biosynthetic process|riboflavin formation|vitamin B2 biosynthesis|vitamin B2 biosynthetic process|riboflavin biosynthesis|riboflavin anabolism|vitamin G biosynthesis|riboflavin synthesis MetaCyc:RIBOSYN2-PWY|Wikipedia:Riboflavin biological_process owl:Class
GO:0042364 biolink:NamedThing water-soluble vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water. got7fsn_ti water-soluble vitamin biosynthesis|water-soluble vitamin synthesis|water-soluble vitamin anabolism|water-soluble vitamin formation biological_process owl:Class
GO:1990452 biolink:NamedThing Parkin-FBXW7-Cul1 ubiquitin ligase complex A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein. got7fsn_ti Parkin-HSel-10-Cullin-1 complex|PRKN-FBXW7-Cul1 complex|Parkin/Cul1/F-box protein complex|Parkin-FBXW7-Cul1 protein complex|Park2-FBXW7-Cul1 complex bf 2014-08-07T14:25:49Z cellular_component owl:Class
GO:0000151 biolink:NamedThing ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. got7fsn_ti cellular_component owl:Class
GO:0018397 biolink:NamedThing peptidyl-phenylalanine bromination to L-2'-bromophenylalanine The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine. got7fsn_ti RESID:AA0174 biological_process owl:Class
GO:0018075 biolink:NamedThing peptidyl-phenylalanine bromination The bromination of phenylalanine. got7fsn_ti RESID:AA0175|RESID:AA0174|RESID:AA0176 biological_process owl:Class
GO:0003013 biolink:NamedThing circulatory system process A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism. got7fsn_ti Wikipedia:Circulatory_system biological_process owl:Class
GO:0007128 biolink:NamedThing meiotic prophase I The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0051324 biolink:NamedThing prophase The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Prophase biological_process owl:Class
GO:0021527 biolink:NamedThing spinal cord association neuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti spinal cord dorsal interneuron differentiation biological_process owl:Class
GO:0021515 biolink:NamedThing cell differentiation in spinal cord The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0120119 biolink:NamedThing flagellum attachment zone A network of cytoskeletal and membranous connections responsible for the lateral attachment of the cilium to the cell body in some trypanosomatid species. got7fsn_ti FAZ Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. krc 2017-12-11T22:46:43Z cellular_component owl:Class
GO:0070161 biolink:NamedThing anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. got7fsn_ti anchoring cell junction cellular_component owl:Class
GO:0000708 biolink:NamedThing meiotic strand invasion The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis. got7fsn_ti meiotic displacement loop formation|meiotic displacement loop biosynthesis|meiotic D-loop biosynthesis|meiotic D-loop formation biological_process owl:Class
GO:0042148 biolink:NamedThing strand invasion The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. got7fsn_ti D-loop formation|displacement loop biosynthesis|Rad51-mediated strand invasion|D-loop biosynthesis|displacement loop formation biological_process owl:Class
GO:0016598 biolink:NamedThing protein arginylation The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. got7fsn_ti protein amino acid arginylation GO:0019130 biological_process owl:Class
GO:0006464 biolink:NamedThing cellular protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). got7fsn_ti protein tagging activity|process resulting in protein modification|protein modification process biological_process owl:Class
GO:0031571 biolink:NamedThing mitotic G1 DNA damage checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint. got7fsn_ti intracellular signal transduction pathway involved in G1 DNA damage checkpoint|intracellular signaling chain involved in G1/S DNA damage checkpoint|intracellular signal transduction involved in G1 DNA damage checkpoint|intracellular signaling pathway involved in G1 DNA damage checkpoint|signal transmission via intracellular cascade involved in G1 DNA damage checkpoint|intracellular signal transduction involved in G1/S DNA damage checkpoint|intracellular signaling pathway involved in G1/S DNA damage checkpoint|G1/S DNA damage checkpoint|intracellular signaling cascade involved in G1 DNA damage checkpoint|intracellular signaling chain involved in G1 DNA damage checkpoint|G1 DNA damage checkpoint|signal transduction via intracellular signaling cascade involved in G1/S DNA damage checkpoint|signal transduction involved in mitotic G1 DNA damage checkpoint|mitotic cell cycle G1/S transition DNA damage checkpoint|signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint|intracellular signal transduction pathway involved in G1/S DNA damage checkpoint|mitotic G1 DNA damage checkpoint|signal transduction via intracellular signaling cascade involved in G1 DNA damage checkpoint|intracellular signaling cascade involved in G1/S DNA damage checkpoint GO:0044783|GO:0072431|GO:1902400 biological_process owl:Class
GO:0044819 biolink:NamedThing mitotic G1/S transition checkpoint signaling A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle. got7fsn_ti mitotic G1/S transition checkpoint https://github.com/geneontology/go-ontology/issues/20935 jl 2013-11-19T14:31:14Z biological_process owl:Class
GO:0048518 biolink:NamedThing positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. got7fsn_ti activation of biological process|upregulation of biological process|positive regulation of physiological process|up regulation of biological process|up-regulation of biological process|stimulation of biological process GO:0043119 biological_process owl:Class
GO:0005852 biolink:NamedThing eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. got7fsn_ti eIF-3|eIF3 cellular_component owl:Class
GO:0018188 biolink:NamedThing peptidyl-proline di-hydroxylation The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline. got7fsn_ti RESID:AA0282 biological_process owl:Class
GO:0019511 biolink:NamedThing peptidyl-proline hydroxylation The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline. got7fsn_ti GO:0006472 biological_process owl:Class
GO:0005385 biolink:NamedThing zinc ion transmembrane transporter activity Enables the transfer of zinc (Zn) ions from one side of a membrane to the other. got7fsn_ti cobalt, zinc uptake permease activity|zinc, cadmium uptake permease activity|zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity|zinc, iron permease activity Reactome:R-HSA-442422|Reactome:R-HSA-437136|Reactome:R-HSA-437084|Reactome:R-HSA-435375|RHEA:29351|Reactome:R-HSA-442345|Reactome:R-HSA-435366|Reactome:R-HSA-437139|Reactome:R-HSA-442405|Reactome:R-HSA-437085|Reactome:R-HSA-442393|Reactome:R-HSA-437129|Reactome:R-HSA-442387|Reactome:R-HSA-5654125|Reactome:R-HSA-442317 molecular_function owl:Class
GO:0022890 biolink:NamedThing inorganic cation transmembrane transporter activity Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage. got7fsn_ti monovalent inorganic cation transmembrane transporter activity|trivalent inorganic cation transmembrane transporter activity|di-, tri-valent inorganic cation transmembrane transporter activity|divalent inorganic cation transmembrane transporter activity GO:0015082|GO:0015077|GO:0072509|GO:0072510 molecular_function owl:Class
GO:0003046 biolink:NamedThing regulation of systemic arterial blood pressure by stress relaxation The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs. got7fsn_ti blood pressure regulation by stress relaxation biological_process owl:Class
GO:0003085 biolink:NamedThing negative regulation of systemic arterial blood pressure The process that reduces the force with which blood travels through the systemic arterial circulatory system. got7fsn_ti biological_process owl:Class
GO:0002468 biolink:NamedThing dendritic cell antigen processing and presentation The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti biological_process owl:Class
GO:0044080 biolink:NamedThing modulation by symbiont of host cGMP-mediated signal transduction Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response. got7fsn_ti modulation by symbiont of host cGMP-mediated signaling|regulation by symbiont of host cGMP-mediated signal transduction|modulation of host cGMP-mediated signal transduction by symbiont|modulation by symbiont of host cGMP-mediated signalling|modulation by symbiont of host cGMP-mediated signal transduction pathway biological_process owl:Class
GO:0010752 biolink:NamedThing regulation of cGMP-mediated signaling Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response. got7fsn_ti regulation of cGMP-mediated signalling biological_process owl:Class
GO:0045605 biolink:NamedThing negative regulation of epidermal cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation. got7fsn_ti down-regulation of epidermal cell differentiation|inhibition of epidermal cell differentiation|downregulation of epidermal cell differentiation|negative regulation of hypodermal cell differentiation|down regulation of epidermal cell differentiation biological_process owl:Class
GO:0045683 biolink:NamedThing negative regulation of epidermis development Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development. got7fsn_ti down regulation of epidermis development|negative regulation of epidermal development|negative regulation of hypodermis development|downregulation of epidermis development|down-regulation of epidermis development|inhibition of epidermis development biological_process owl:Class
GO:0043330 biolink:NamedThing response to exogenous dsRNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. got7fsn_ti response to viral dsRNA|response to exogenous double-stranded RNA Note that the presence of exogenous double-stranded RNA is usually indicative of a viral infection. Consider also annotating to 'response to virus ; GO:0009615'. biological_process owl:Class
GO:0043331 biolink:NamedThing response to dsRNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. got7fsn_ti response to double-stranded RNA biological_process owl:Class
GO:0048446 biolink:NamedThing petal morphogenesis The process in which the anatomical structures of the petal are generated and organized. got7fsn_ti GO:0048418 biological_process owl:Class
GO:0048444 biolink:NamedThing floral organ morphogenesis The process in which the anatomical structures of the floral organ are generated and organized. got7fsn_ti GO:0048434 biological_process owl:Class
GO:0061648 biolink:NamedThing tooth replacement The process whose specific outcome is the replacement of an existing tooth with another tooth. got7fsn_ti dph 2014-10-02T15:26:53Z biological_process owl:Class
GO:0042476 biolink:NamedThing odontogenesis The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food. got7fsn_ti tooth development|odontogeny|tooth morphogenesis|odontogenesis of calcareous or chitinous tooth|odontosis GO:0042477 Wikipedia:Odontogenesis biological_process owl:Class
GO:0043480 biolink:NamedThing pigment accumulation in tissues The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus. got7fsn_ti organismal pigment accumulation biological_process owl:Class
GO:0052170 biolink:NamedThing suppression by symbiont of host innate immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation of host innate immune response|negative regulation by symbiont of host innate immunity|down regulation by symbiont of host innate immunity|inhibition by symbiont of host innate immunity|negative regulation by symbiont of host innate immune response|downregulation by symbiont of host innate immunity|down-regulation by symbiont of host innate immunity|negative regulation of innate immune response in other organism GO:0052309 biological_process owl:Class
GO:0052562 biolink:NamedThing suppression by symbiont of host immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti down-regulation by symbiont of host immune response|inhibition by symbiont of host immune response|negative regulation by symbiont of host immune response|negative regulation by organism of immune response of other organism involved in symbiotic interaction|downregulation by symbiont of host immune response|down regulation by symbiont of host immune response GO:0052561 biological_process owl:Class
GO:0036375 biolink:NamedThing Kibra-Ex-Mer complex An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2. got7fsn_ti Kbr, Ex and Mer complex|KEM complex bf 2013-05-07T10:05:15Z cellular_component owl:Class
GO:0070357 biolink:NamedThing alphav-beta3 integrin-CD47 complex A protein complex that consists of an alphav-beta3 integrin complex bound to CD47 (also known as IAP). got7fsn_ti ITGB3-ITGAV-CD47 complex cellular_component owl:Class
GO:1990065 biolink:NamedThing Dxr protein complex A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). got7fsn_ti 1-deoxy-D-xylulose 5-phosphate reductoisomerase complex bhm 2013-03-27T16:58:54Z cellular_component owl:Class
GO:0036028 biolink:NamedThing protein C inhibitor-thrombin complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin. got7fsn_ti serpin A5-thrombin complex|plasma serine protease inhibitor-thrombin complex|PCI-thrombin complex|protein C inhibitor-coagulation factor II complex|protein C inhibitor-F2 complex|SERPINA5-thrombin complex bf 2011-10-19T01:40:18Z cellular_component owl:Class
GO:0097180 biolink:NamedThing serine protease inhibitor complex A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity. got7fsn_ti serine-type endopeptidase inhibitor complex|serpin complex pr 2011-10-16T08:55:17Z cellular_component owl:Class
GO:0036025 biolink:NamedThing protein C inhibitor-TMPRSS11E complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E. got7fsn_ti PCI-TMPRSS11E complex|SERPINA5-TMPRSS11E complex|plasma serine protease inhibitor-TMPRSS11E complex|serpin A5-TMPRSS11E complex|protein C inhibitor-transmembrane protease serine 11E complex bf 2011-10-19T01:29:08Z cellular_component owl:Class
GO:0002205 biolink:NamedThing somatic hypermutation of immunoglobulin genes involved in immune response Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response. got7fsn_ti somatic hypermutation of immunoglobulin genes during immune response|somatic hypermutation of antibody genes during immune response biological_process owl:Class
GO:0016446 biolink:NamedThing somatic hypermutation of immunoglobulin genes Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. got7fsn_ti somatic hypermutation of antibody genes biological_process owl:Class
GO:0030649 biolink:NamedThing aminoglycoside antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. got7fsn_ti aminoglycoside antibiotic degradation|aminoglycoside antibiotic breakdown|aminoglycoside antibiotic catabolism biological_process owl:Class
GO:0017001 biolink:NamedThing antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. got7fsn_ti antibiotic catabolism|antibiotic degradation|antibiotic breakdown biological_process owl:Class
GO:0035132 biolink:NamedThing post-embryonic medial fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. got7fsn_ti post-embryonic unpaired fin morphogenesis biological_process owl:Class
GO:0035120 biolink:NamedThing post-embryonic appendage morphogenesis The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. got7fsn_ti biological_process owl:Class
GO:0035622 biolink:NamedThing intrahepatic bile duct development The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver). got7fsn_ti IHBD development|intrahepatic biliary duct development bf 2010-12-08T04:10:50Z biological_process owl:Class
GO:0061827 biolink:NamedThing sperm head The part of the late spermatid or spermatozoon that contains the nucleus and acrosome. got7fsn_ti dph 2017-01-15T10:39:00Z cellular_component owl:Class
GO:0098518 biolink:NamedThing polynucleotide phosphatase activity Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate. got7fsn_ti dos 2013-09-26T11:02:35Z molecular_function owl:Class
GO:0010374 biolink:NamedThing stomatal complex development The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells. got7fsn_ti biological_process owl:Class
GO:0032200 biolink:NamedThing telomere organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins. got7fsn_ti organization of chromosome, telomeric region|telomere organization and biogenesis|telomere organisation|chromosome organization, telomeric biological_process owl:Class
GO:0051276 biolink:NamedThing chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. got7fsn_ti maintenance of genome integrity|chromosome organization and biogenesis|nuclear genome maintenance|chromosome organisation GO:0051277|GO:0007001 biological_process owl:Class
GO:0033103 biolink:NamedThing protein secretion by the type VI secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence. got7fsn_ti protein secretion by the T6SS|type VI protein secretion system|protein secretion by the type VI protein secretion system Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'. biological_process owl:Class
GO:0047961 biolink:NamedThing glycine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. got7fsn_ti acyl-CoA:glycine N-acyltransferase activity|glycine acyltransferase activity|glycine-N-acylase activity MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN|RHEA:19869|EC:2.3.1.13|Reactome:R-HSA-2534040 molecular_function owl:Class
GO:0030175 biolink:NamedThing filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. got7fsn_ti A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473. GO:0030028 NIF_Subcellular:sao1046371754|Wikipedia:Filopodia cellular_component owl:Class
GO:0098858 biolink:NamedThing actin-based cell projection A cell projection supported by an assembly of actin filaments, and which lacks microtubules. got7fsn_ti cellular_component owl:Class
GO:0032341 biolink:NamedThing aldosterone metabolic process The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. got7fsn_ti aldosterone metabolism biological_process owl:Class
GO:0008207 biolink:NamedThing C21-steroid hormone metabolic process The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. got7fsn_ti C21-steroid hormone metabolism biological_process owl:Class
GO:0035993 biolink:NamedThing deltoid tuberosity development The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase. got7fsn_ti bf 2011-08-30T01:46:53Z biological_process owl:Class
GO:0018725 biolink:NamedThing trans-3,4-dihydrodiolphenanthrene sulfotransferase activity Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate. got7fsn_ti trans-3,4-dihydrodiolphenanthrene sulphotransferase activity UM-BBD_reactionID:r0558 molecular_function owl:Class
GO:0071261 biolink:NamedThing Ssh1 translocon complex A translocon complex that contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Ssh1p, Sbh2p, and Sss1p. The Ssh1 translocon complex is involved in the cotranslational pathway of protein transport across the ER membrane, and recognizes proteins bearing strongly hydrophobic signal sequences. got7fsn_ti Ssh1p-Sss1p-Sbh2p complex mah 2009-12-08T02:22:55Z cellular_component owl:Class
GO:0071256 biolink:NamedThing translocon complex A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins. got7fsn_ti Sec complex-associated translocon complex mah 2009-12-08T02:08:03Z GO:0031206 cellular_component owl:Class
GO:0040019 biolink:NamedThing positive regulation of embryonic development Any process that activates or increases the frequency, rate or extent of embryonic development. got7fsn_ti up-regulation of embryonic development|stimulation of embryonic development|upregulation of embryonic development|up regulation of embryonic development|activation of embryonic development biological_process owl:Class
GO:0051094 biolink:NamedThing positive regulation of developmental process Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). got7fsn_ti activation of developmental process|stimulation of developmental process|up-regulation of developmental process|upregulation of developmental process|up regulation of developmental process biological_process owl:Class
GO:0048098 biolink:NamedThing antennal joint development The process whose specific outcome is the progression of the antennal joint over time, from its formation to the mature structure. The antennal joint is the joint between antennal segments. got7fsn_ti biological_process owl:Class
GO:0042128 biolink:NamedThing nitrate assimilation The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances. got7fsn_ti assimilatory nitrate reduction MetaCyc:PWY-381 biological_process owl:Class
GO:0071941 biolink:NamedThing nitrogen cycle metabolic process A nitrogen compound metabolic process that contributes to the nitrogen cycle. The nitrogen cycle is a series of metabolic pathways by which nitrogen is converted between various forms and redox states; it encompasses pathways in which nitrogen is acted upon directly, such as nitrification, denitrification, nitrogen fixation, and mineralization. got7fsn_ti mah 2010-09-30T05:21:03Z Wikipedia:Nitrogen_cycle biological_process owl:Class
GO:0050639 biolink:NamedThing 10-hydroxytaxane O-acetyltransferase activity Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C. got7fsn_ti acetyl coenzyme A: 10-hydroxytaxane O-acetyltransferase activity|acetyl coenzyme A:10-hydroxytaxane O-acetyltransferase activity|acetyl-CoA:taxan-10beta-ol O-acetyltransferase EC:2.3.1.163|MetaCyc:2.3.1.163-RXN|RHEA:18837|KEGG_REACTION:R07252 molecular_function owl:Class
GO:1902105 biolink:NamedThing regulation of leukocyte differentiation Any process that modulates the frequency, rate or extent of leukocyte differentiation. got7fsn_ti regulation of immune cell differentiation|regulation of leucocyte differentiation pr 2013-05-02T17:32:42Z biological_process owl:Class
GO:0045595 biolink:NamedThing regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features. got7fsn_ti biological_process owl:Class
GO:0004956 biolink:NamedThing prostaglandin D receptor activity Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity. got7fsn_ti PGD receptor activity|PGD(2) receptor activity molecular_function owl:Class
GO:0004955 biolink:NamedThing prostaglandin receptor activity Combining with a prostaglandin (PG) to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0016217 biolink:NamedThing N-ethylammeline chlorohydrolase activity Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+. got7fsn_ti MetaCyc:R465-RXN molecular_function owl:Class
GO:0019120 biolink:NamedThing hydrolase activity, acting on acid halide bonds, in C-halide compounds Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage. got7fsn_ti Reactome:R-HSA-9011595|EC:3.8.1.- molecular_function owl:Class
GO:0070065 biolink:NamedThing cellubrevin-VAMP4-syntaxin-16 complex A SNARE complex that contains cellubrevin (VAMP3), VAMP4, and syntaxin 16 (or orthologs thereof). got7fsn_ti Vamp3-Vamp4-Stx16 complex|SNARE complex (Vamp3, Vamp4, Stx16) cellular_component owl:Class
GO:0031201 biolink:NamedThing SNARE complex A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25. got7fsn_ti cellular_component owl:Class
GO:0090565 biolink:NamedThing protein-phosphocysteine-mannitol phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti tb 2014-04-08T15:03:08Z molecular_function owl:Class
GO:0090563 biolink:NamedThing protein-phosphocysteine-sugar phosphotransferase activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti tb 2014-04-08T14:58:00Z molecular_function owl:Class
GO:0099610 biolink:NamedThing action potential initiation The initiating cycle of an action potential. In vertebrate neurons this typically occurs at an axon hillock. Not all initiated axon potentials propagate. got7fsn_ti action potential firing|action potential triggering biological_process owl:Class
GO:0001508 biolink:NamedThing action potential A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. got7fsn_ti Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. biological_process owl:Class
GO:0030629 biolink:NamedThing U6 snRNA 3'-end binding Binding to a U6 small nuclear RNA (U6 snRNA) at the 3' end. got7fsn_ti U6 snRNA 3' end binding Note that this term may be useful for annotating small nuclear RNAs (snRNAs). molecular_function owl:Class
GO:0017070 biolink:NamedThing U6 snRNA binding Binding to a U6 small nuclear RNA (U6 snRNA). got7fsn_ti molecular_function owl:Class
GO:1990428 biolink:NamedThing miRNA transport The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. got7fsn_ti microRNA transport jl 2014-07-29T14:03:46Z biological_process owl:Class
GO:0050658 biolink:NamedThing RNA transport The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0051468 biolink:NamedThing detection of glucocorticoid hormone stimulus The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. got7fsn_ti biological_process owl:Class
GO:0051384 biolink:NamedThing response to glucocorticoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. got7fsn_ti response to glucocorticoid stimulus biological_process owl:Class
GO:0099015 biolink:NamedThing degradation of host chromosome by virus The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis. got7fsn_ti VZ:3947 biological_process owl:Class
GO:0039637 biolink:NamedThing catabolism by virus of host DNA The breakdown of host DNA, deoxyribonucleic acid, by a virus. got7fsn_ti bf 2012-08-10T15:59:22Z biological_process owl:Class
GO:0061681 biolink:NamedThing Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate. got7fsn_ti dph 2015-01-22T08:55:22Z MetaCyc:ENTNER-DOUDOROFF-PWY-III biological_process owl:Class
GO:0061679 biolink:NamedThing Entner-Doudoroff pathway through gluconate The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate. got7fsn_ti gluconate pathway dph 2015-01-16T15:41:22Z biological_process owl:Class
GO:0044525 biolink:NamedThing peptidyl-cystine sulfhydration The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide. got7fsn_ti jl 2012-03-15T09:44:07Z biological_process owl:Class
GO:0044524 biolink:NamedThing protein sulfhydration The modification of a protein amino acid by the addition of sulfur. got7fsn_ti jl 2012-03-15T09:39:33Z biological_process owl:Class
GO:0086073 biolink:NamedThing bundle of His cell-Purkinje myocyte adhesion involved in cell communication The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate. got7fsn_ti dph 2011-11-22T10:00:30Z biological_process owl:Class
GO:0034113 biolink:NamedThing heterotypic cell-cell adhesion The attachment of a cell to a cell of a different type via adhesion molecules. got7fsn_ti Note that this term is not synonymous with 'heterophilic cell adhesion ; GO:0007157'; the process may occur by homophilic or heterophilic mechanisms. biological_process owl:Class
GO:0007339 biolink:NamedThing binding of sperm to zona pellucida The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. got7fsn_ti ZPG binding biological_process owl:Class
GO:0035036 biolink:NamedThing sperm-egg recognition The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization. got7fsn_ti biological_process owl:Class
GO:1903042 biolink:NamedThing negative regulation of chondrocyte hypertrophy Any process that stops, prevents or reduces the frequency, rate or extent of chondrocyte hypertrophy. got7fsn_ti down regulation of chondrocyte hypertrophy|inhibition of chondrocyte hypertrophy|down-regulation of chondrocyte hypertrophy|downregulation of chondrocyte hypertrophy mr 2014-05-20T21:23:19Z biological_process owl:Class
GO:0042861 biolink:NamedThing achromobactin biosynthetic process The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore. got7fsn_ti achromobactin anabolism|achromobactin formation|achromobactin synthesis|achromobactin biosynthesis GO:0031182|GO:0031181 biological_process owl:Class
GO:0019290 biolink:NamedThing siderophore biosynthetic process The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. got7fsn_ti siderophore biosynthetic process, peptide formation|siderophore biosynthesis|siderochrome biosynthetic process|siderophore anabolism|siderophore formation|siderochrome biosynthesis|siderophore synthesis|siderophore biosynthetic process, peptide modification GO:0031180|GO:0031178 biological_process owl:Class
GO:0032076 biolink:NamedThing negative regulation of deoxyribonuclease activity Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. got7fsn_ti downregulation of deoxyribonuclease activity|deoxyribonuclease inhibitor|down regulation of deoxyribonuclease activity|inhibition of deoxyribonuclease activity|DNase inhibitor|down-regulation of deoxyribonuclease activity biological_process owl:Class
GO:0051053 biolink:NamedThing negative regulation of DNA metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA. got7fsn_ti inhibition of DNA metabolic process|down-regulation of DNA metabolic process|negative regulation of DNA metabolism|down regulation of DNA metabolic process|downregulation of DNA metabolic process biological_process owl:Class
GO:0102144 biolink:NamedThing carboxyspermidine dehydrogenase II activity Catalysis of the reaction: carboxyspermidine + H2O + NADP <=> L-aspartic acid 4-semialdehyde betaine + 1,4-butanediammonium + NADPH + H+. got7fsn_ti MetaCyc:RXN-11566|RHEA:34111 molecular_function owl:Class
GO:0044839 biolink:NamedThing cell cycle G2/M phase transition The cell cycle process by which a cell in G2 phase commits to M phase. got7fsn_ti jl 2014-03-05T14:56:45Z biological_process owl:Class
GO:0044770 biolink:NamedThing cell cycle phase transition The cell cycle process by which a cell commits to entering the next cell cycle phase. got7fsn_ti cell cycle transition jl 2013-02-28T12:54:59Z biological_process owl:Class
GO:0050845 biolink:NamedThing teichuronic acid biosynthetic process The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. got7fsn_ti teichuronic acid anabolism|teichuronic acid biosynthesis|teichuronic acid formation|teichuronic acid synthesis biological_process owl:Class
GO:0016053 biolink:NamedThing organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. got7fsn_ti organic acid biosynthesis|organic acid formation|organic acid synthesis|organic acid anabolism biological_process owl:Class
GO:0002240 biolink:NamedThing response to molecule of oomycetes origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin. got7fsn_ti response to oomycetes associated molecule biological_process owl:Class
GO:0010033 biolink:NamedThing response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus. got7fsn_ti process resulting in tolerance to organic substance GO:1990367 biological_process owl:Class
GO:0016775 biolink:NamedThing phosphotransferase activity, nitrogenous group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). got7fsn_ti EC:2.7.3.- molecular_function owl:Class
GO:0016772 biolink:NamedThing transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). got7fsn_ti Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. EC:2.7.-.- molecular_function owl:Class
GO:0033142 biolink:NamedThing progesterone receptor binding Binding to a progesterone receptor. got7fsn_ti molecular_function owl:Class
GO:0016922 biolink:NamedThing nuclear receptor binding Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. got7fsn_ti steroid hormone receptor binding|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|ligand-dependent nuclear receptor interactor activity GO:0035257|GO:0035258 molecular_function owl:Class
GO:0120223 biolink:NamedThing larynx morphogenesis The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration. got7fsn_ti laryngeal morphogenesis krc 2020-02-22T01:42:04Z biological_process owl:Class
GO:0009887 biolink:NamedThing animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti histogenesis and organogenesis biological_process owl:Class
GO:0036284 biolink:NamedThing tubulobulbar complex Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes. got7fsn_ti TBC bf 2012-07-16T10:26:35Z cellular_component owl:Class
GO:0032541 biolink:NamedThing cortical endoplasmic reticulum A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements. got7fsn_ti ER-PM peripheral junction|peripheral ER|peripheral endoplasmic reticulum|cortical ER The dynamic nature of the cortical ER and the movements it undergoes (branching and ring closure) has been shown in both yeast and mammalian cells, so appears highly conserved. (PMID:10931860) cellular_component owl:Class
GO:0071782 biolink:NamedThing endoplasmic reticulum tubular network A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. got7fsn_ti ER tubular network mah 2010-09-01T01:32:55Z cellular_component owl:Class
GO:0036018 biolink:NamedThing cellular response to erythropoietin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. got7fsn_ti bf 2011-10-12T10:12:18Z biological_process owl:Class
GO:0071345 biolink:NamedThing cellular response to cytokine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. got7fsn_ti mah 2009-12-11T02:41:12Z biological_process owl:Class
GO:0060172 biolink:NamedThing astral microtubule depolymerization The removal of tubulin heterodimers from one or both ends of an astral microtubule. An astral microtubule is any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. got7fsn_ti biological_process owl:Class
GO:0001982 biolink:NamedThing baroreceptor response to decreased systemic arterial blood pressure The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels. got7fsn_ti biological_process owl:Class
GO:0003084 biolink:NamedThing positive regulation of systemic arterial blood pressure The process that increases the force with which blood travels through the systemic arterial circulatory system. got7fsn_ti biological_process owl:Class
GO:0071603 biolink:NamedThing endothelial cell-cell adhesion The attachment of an endothelial cell to another endothelial cell via adhesion molecules. got7fsn_ti mah 2010-02-04T05:21:30Z biological_process owl:Class
GO:0090136 biolink:NamedThing epithelial cell-cell adhesion The attachment of an epithelial cell to another epithelial cell via adhesion molecules. got7fsn_ti tb 2009-12-08T01:56:53Z biological_process owl:Class
GO:0007523 biolink:NamedThing larval visceral muscle development The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0007522 biolink:NamedThing visceral muscle development The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0071755 biolink:NamedThing IgM B cell receptor complex An IgM immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti surface IgM|membrane-bound IgM Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0071753 biolink:NamedThing IgM immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0008170 biolink:NamedThing N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. got7fsn_ti EC:2.1.1.- molecular_function owl:Class
GO:0099558 biolink:NamedThing maintenance of synapse structure A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. got7fsn_ti synaptic maintenance biological_process owl:Class
GO:0050808 biolink:NamedThing synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). got7fsn_ti synapse organisation|synapse development|synapse organization and biogenesis|synapse morphogenesis biological_process owl:Class
GO:0051363 biolink:NamedThing peptidoglycan-protein cross-linking via L-alanyl-pentaglycyl-murein The process of linking a protein to peptidoglycan via a carboxy terminal alanine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. got7fsn_ti Note that this modification may be unique to the species Finegoldia (Peptostreptococcus) magnus. RESID:AA0383 biological_process owl:Class
GO:0018194 biolink:NamedThing peptidyl-alanine modification The modification of peptidyl-alanine. got7fsn_ti biological_process owl:Class
GO:0035649 biolink:NamedThing Nrd1 complex A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p. got7fsn_ti bf 2011-01-25T10:23:25Z cellular_component owl:Class
GO:0047878 biolink:NamedThing erythritol kinase activity Catalysis of the reaction: ATP + erythritol = D-erythritol 4-phosphate + ADP + 2 H(+). got7fsn_ti ATP:erythritol 4-phosphotransferase activity|erythritol kinase (phosphorylating) MetaCyc:ERYTHRITOL-KINASE-RXN|EC:2.7.1.27|KEGG_REACTION:R02430|RHEA:20708 molecular_function owl:Class
GO:0010244 biolink:NamedThing response to low fluence blue light stimulus by blue low-fluence system Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes. got7fsn_ti response to low fluence blue light|response to low fluence blue light by blf system biological_process owl:Class
GO:0021637 biolink:NamedThing trigeminal nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. got7fsn_ti CN V structural organization|trigeminal nerve structural organisation biological_process owl:Class
GO:0021604 biolink:NamedThing cranial nerve structural organization The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti cranial nerve structural organisation biological_process owl:Class
GO:0035851 biolink:NamedThing Krueppel-associated box domain binding Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors. got7fsn_ti KRAB domain binding|Krueppel-associated box binding bf 2011-05-11T11:41:16Z molecular_function owl:Class
GO:0055013 biolink:NamedThing cardiac muscle cell development The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state. got7fsn_ti cardiomyocyte cell development|heart muscle cell development|heart muscle fiber development|cardiac muscle fiber development|cardiac muscle fibre development GO:0048739 biological_process owl:Class
GO:0055006 biolink:NamedThing cardiac cell development The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual. got7fsn_ti heart cell development|cardiocyte development biological_process owl:Class
GO:0090598 biolink:NamedThing male anatomical structure morphogenesis The processes by which anatomical structures that are only present in the male organism are generated and organized. got7fsn_ti tb 2014-08-22T13:29:45Z biological_process owl:Class
GO:0009653 biolink:NamedThing anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form. got7fsn_ti anatomical structure organization|morphogenesis|embryogenesis and morphogenesis Wikipedia:Morphogenesis biological_process owl:Class
GO:0072558 biolink:NamedThing NLRP1 inflammasome complex An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential. got7fsn_ti NALP1 inflammasome complex mah 2011-01-27T12:03:50Z cellular_component owl:Class
GO:0036460 biolink:NamedThing cellular response to cell envelope stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope. got7fsn_ti envelope stress response bf 2014-01-08T15:15:50Z biological_process owl:Class
GO:0009528 biolink:NamedThing plastid inner membrane The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma. got7fsn_ti cellular_component owl:Class
GO:0042170 biolink:NamedThing plastid membrane Either of the lipid bilayers that surround a plastid and form the plastid envelope. got7fsn_ti cellular_component owl:Class
GO:0048257 biolink:NamedThing 3'-flap endonuclease activity Catalysis of the cleavage of a 3' flap structure in DNA, but not other DNA structures; processes the 3' ends of Okazaki fragments in lagging strand DNA synthesis. got7fsn_ti 3' flap endonuclease activity molecular_function owl:Class
GO:0098735 biolink:NamedThing positive regulation of the force of heart contraction Any process that increases the force of heart muscle contraction. got7fsn_ti biological_process owl:Class
GO:0002026 biolink:NamedThing regulation of the force of heart contraction Any process that modulates the extent of heart contraction, changing the force with which blood is propelled. got7fsn_ti heart inotropy|cardiac inotropy biological_process owl:Class
GO:0006315 biolink:NamedThing homing of group II introns Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure. got7fsn_ti biological_process owl:Class
GO:0018666 biolink:NamedThing 2,4-dichlorophenol 6-monooxygenase activity Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O. got7fsn_ti 2,4-dichlorophenol hydroxylase activity|2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)|2,4-dichlorophenol monooxygenase activity EC:1.14.13.20|MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN|RHEA:20920|UM-BBD_enzymeID:e0152 molecular_function owl:Class
GO:0098736 biolink:NamedThing negative regulation of the force of heart contraction Any process that decreases the force of heart muscle contraction. got7fsn_ti biological_process owl:Class
GO:0075130 biolink:NamedThing modulation by symbiont of host protein kinase-mediated signal transduction Any process in which the symbiont modulates the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075099". biological_process owl:Class
GO:0052027 biolink:NamedThing modulation by symbiont of host signal transduction pathway Any process in which an organism modulates the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host signal transduction|modulation of host signal transduction by symbiont|modulation of signal transduction in other organism involved in symbiotic interaction|regulation by symbiont of host signal transduction pathway GO:0052250 biological_process owl:Class
GO:0046565 biolink:NamedThing 3-dehydroshikimate dehydratase activity Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate. got7fsn_ti EC:4.2.1.118|MetaCyc:DHSHIKIMATE-DEHYDRO-RXN|RHEA:24848 molecular_function owl:Class
GO:0062095 biolink:NamedThing endoplasmic reticulum-peroxisome tethering The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other. got7fsn_ti dph 2018-11-21T13:28:50Z biological_process owl:Class
GO:0060151 biolink:NamedThing peroxisome localization Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. got7fsn_ti peroxisome localisation biological_process owl:Class
GO:0009083 biolink:NamedThing branched-chain amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. got7fsn_ti branched chain family amino acid degradation|branched chain family amino acid breakdown|branched chain family amino acid catabolic process|branched chain family amino acid catabolism biological_process owl:Class
GO:0009063 biolink:NamedThing cellular amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. got7fsn_ti cellular amino acid breakdown|amino acid catabolic process|cellular amino acid degradation|cellular amino acid catabolism biological_process owl:Class
GO:0005703 biolink:NamedThing polytene chromosome puff A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription. got7fsn_ti cellular_component owl:Class
GO:0098687 biolink:NamedThing chromosomal region Any subdivision of a chromosome along its length. got7fsn_ti chromosome region Chromosomal regions include parts that are not part of the chromatin. Examples include the kinetochore. cellular_component owl:Class
GO:0034317 biolink:NamedThing nicotinic acid riboside kinase activity Catalysis of the reaction: ATP + nicotinic acid riboside = ADP + nicotinic acid mononucleotide. got7fsn_ti MetaCyc:RXN-8443 molecular_function owl:Class
GO:0019206 biolink:NamedThing nucleoside kinase activity Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. got7fsn_ti Reactome:R-HSA-109903|Reactome:R-HSA-73598|Reactome:R-HSA-110137|Reactome:R-HSA-109671|Reactome:R-HSA-73632|Reactome:R-HSA-74207|Reactome:R-HSA-73599|Reactome:R-HSA-109759|Reactome:R-HSA-110138 molecular_function owl:Class
GO:0043050 biolink:NamedThing pharyngeal pumping The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes. got7fsn_ti pumping behavior biological_process owl:Class
GO:0042755 biolink:NamedThing eating behavior The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. got7fsn_ti eating behaviour biological_process owl:Class
GO:0050240 biolink:NamedThing pyrogallol 1,2-oxygenase activity Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+). got7fsn_ti pyrogallol 1,2-dioxygenase activity|1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (decyclizing) MetaCyc:PYROGALLOL-12-OXYGENASE-RXN|KEGG_REACTION:R03246|RHEA:19673|EC:1.13.11.35 molecular_function owl:Class
GO:0047212 biolink:NamedThing 2-coumarate O-beta-glucosyltransferase activity Catalysis of the reaction: trans-2-coumarate + UDP-D-glucose = trans-beta-D-glucosyl-2-hydroxycinnamate + H(+) + UDP. got7fsn_ti UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity|UDPglucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity|UDPG:o-coumaric acid O-glucosyltransferase activity|uridine diphosphoglucose-o-coumarate glucosyltransferase activity MetaCyc:2.4.1.114-RXN|KEGG_REACTION:R03710|EC:2.4.1.114|RHEA:10236 molecular_function owl:Class
GO:0035251 biolink:NamedThing UDP-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. got7fsn_ti Reactome:R-HSA-1912353|MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0035747 biolink:NamedThing natural killer cell chemotaxis The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti bf 2011-03-17T02:40:10Z biological_process owl:Class
GO:0048247 biolink:NamedThing lymphocyte chemotaxis The directed movement of a lymphocyte in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0061860 biolink:NamedThing DNA clamp unloader activity Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their removal from the DNA duplex, driven by ATP hydrolysis. got7fsn_ti dph 2017-04-03T11:49:46Z molecular_function owl:Class
GO:0008094 biolink:NamedThing ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis. got7fsn_ti ATPase, acting on DNA|ATPase activity, acting on DNA|DNA-dependent adenosinetriphosphatase activity|adenosinetriphosphatase (DNA-dependent)|DNA dependent ATPase activity|DNA-dependent ATPase activity https://github.com/geneontology/go-ontology/issues/20876|https://github.com/geneontology/go-ontology/issues/21612|https://github.com/geneontology/go-ontology/issues/21775 GO:0004011 molecular_function owl:Class
GO:0018682 biolink:NamedThing atrazine N-dealkylase activity Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O. got7fsn_ti atrazine monooxygenase activity MetaCyc:R461-RXN|UM-BBD_reactionID:r0127|EC:1.14.15.- molecular_function owl:Class
GO:0140313 biolink:NamedThing molecular sequestering activity The selective interaction of a protein with a specific molecule to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell. got7fsn_ti pg 2019-03-28T10:00:25Z molecular_function owl:Class
GO:0097068 biolink:NamedThing response to thyroxine A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. got7fsn_ti response to thyroxine stimulus|response to T4 stimulus|response to T4 pr 2011-06-14T05:05:07Z biological_process owl:Class
GO:0097066 biolink:NamedThing response to thyroid hormone A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus. got7fsn_ti response to thyroid hormone stimulus pr 2011-06-14T05:01:18Z biological_process owl:Class
GO:0021895 biolink:NamedThing cerebral cortex neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex. got7fsn_ti biological_process owl:Class
GO:0021953 biolink:NamedThing central nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system. got7fsn_ti biological_process owl:Class
GO:0003241 biolink:NamedThing growth involved in heart morphogenesis Developmental growth that contributes to the shaping of the heart. got7fsn_ti dph 2009-10-13T11:28:46Z biological_process owl:Class
GO:0016402 biolink:NamedThing pristanoyl-CoA oxidase activity Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide. got7fsn_ti RHEA:40459|Reactome:R-HSA-389889|Reactome:R-HSA-389891 molecular_function owl:Class
GO:0003997 biolink:NamedThing acyl-CoA oxidase activity Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. got7fsn_ti fatty acyl-CoA oxidase activity|acyl-CoA:oxygen 2-oxidoreductase activity|fatty acyl-coenzyme A oxidase activity|acyl coenzyme A oxidase activity RHEA:38959|EC:1.3.3.6|Reactome:R-HSA-193369|Reactome:R-HSA-390256|Reactome:R-HSA-2066787|Reactome:R-HSA-192335|MetaCyc:ACYL-COA-OXIDASE-RXN molecular_function owl:Class
GO:0050988 biolink:NamedThing N-terminal peptidyl-methionine carboxylation The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine. got7fsn_ti RESID:AA0363 biological_process owl:Class
GO:0050989 biolink:NamedThing N-terminal protein amino acid carboxylation The carboxylation of the N-terminal amino acid of proteins. got7fsn_ti biological_process owl:Class
GO:0051403 biolink:NamedThing stress-activated MAPK cascade A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. got7fsn_ti MAPK14 cascade|MAPK12 cascade|stress-activated MAPKKK signalling pathway|p38 MAPK signaling|stress-activated MAPK signaling pathway|p38 cascade|p38 MAPK signalling|MAPK11 cascade|stress-activated MAPK signalling pathway|MAPK13 cascade|stress-activated MAPKKK signaling pathway|SAPK cascade|stress-activated MAPKKK cascade biological_process owl:Class
GO:0031098 biolink:NamedThing stress-activated protein kinase signaling cascade A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals. got7fsn_ti JNK signalling pathway|stress-activated protein kinase signaling pathway|stress-activated protein kinase signalling pathway|JNK signaling pathway|SAPK signalling pathway|SAPK signaling pathway biological_process owl:Class
GO:0038086 biolink:NamedThing VEGF-activated platelet-derived growth factor receptor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGF-activated platelet-derived growth factor receptor signalling pathway|vascular endothelial growth factor-activated platelet-derived growth factor receptor signaling pathway|VEGF-activated PDGFR signalling pathway|VEGF/PDGFR signaling pathway|VEGF-A/PDGFR signaling bf 2012-02-01T03:05:43Z biological_process owl:Class
GO:0048008 biolink:NamedThing platelet-derived growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. got7fsn_ti PDGFR signaling pathway|PDGF receptor signalling pathway|PDGF receptor signaling pathway biological_process owl:Class
GO:0097226 biolink:NamedThing sperm mitochondrial sheath The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. got7fsn_ti pr 2012-01-25T01:25:08Z cellular_component owl:Class
GO:0060735 biolink:NamedThing regulation of eIF2 alpha phosphorylation by dsRNA Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to double-stranded RNA. got7fsn_ti regulation of eIF2 alpha phosphorylation by double-stranded RNA|regulation of eIF2 alpha phosphorylation by PKR dph 2009-06-12T02:27:14Z biological_process owl:Class
GO:0001932 biolink:NamedThing regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. got7fsn_ti regulation of protein amino acid phosphorylation biological_process owl:Class
GO:0050079 biolink:NamedThing acetylenecarboxylate hydratase activity, producing 3-oxopropanoate Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O. got7fsn_ti 3-oxopropanoate hydro-lyase activity|acetylmonocarboxylic acid hydrase activity|acetylenecarboxylate hydratase activity|acetylenemonocarboxylate hydrase activity|acetylenemonocarboxylate hydratase activity|malonate-semialdehyde dehydratase activity|acetylenecarboxylate hydratase activity, producing malonate-semialdehyde|alkynoate hydratase activity|3-oxopropanoate hydro-lyase (propynoate-forming) Note that this function was formerly EC:4.2.1.71. GO:0047607 EC:4.2.1.27|MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN|RHEA:17957 molecular_function owl:Class
GO:0021601 biolink:NamedThing abducens nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. got7fsn_ti CN VI maturation biological_process owl:Class
GO:0021605 biolink:NamedThing cranial nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti biological_process owl:Class
GO:0072683 biolink:NamedThing T cell extravasation The migration of a T cell from the blood vessels into the surrounding tissue. got7fsn_ti T lymphocyte extravasation|T-lymphocyte extravasation|T-cell extravasation mah 2011-02-22T04:05:45Z biological_process owl:Class
GO:0045123 biolink:NamedThing cellular extravasation The migration of a leukocyte from the blood vessels into the surrounding tissue. got7fsn_ti immune cell cellular extravasation|leucocyte cellular extravasation|transendothelial leukocyte migration|leukocyte cellular extravasation Wikipedia:Leukocyte_extravasation biological_process owl:Class
GO:0021700 biolink:NamedThing developmental maturation A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state. got7fsn_ti biological_process owl:Class
GO:0048932 biolink:NamedThing myelination of posterior lateral line nerve axons The formation of compact myelin sheaths around the axons of the posterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0048897 biolink:NamedThing myelination of lateral line nerve axons The formation of compact myelin sheaths around the axons of a lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0061202 biolink:NamedThing clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted gamma-aminobutyric acid transport vesicle. got7fsn_ti clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted GABA transport vesicle membrane dph 2010-07-29T10:54:33Z cellular_component owl:Class
GO:0030665 biolink:NamedThing clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle. got7fsn_ti clathrin coated vesicle membrane cellular_component owl:Class
GO:0009718 biolink:NamedThing anthocyanin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. got7fsn_ti anthocyanin biosynthesis|anthocyanin biosynthetic process|anthocyanin synthesis|anthocyanin anabolism|anthocyanin formation biological_process owl:Class
GO:0046148 biolink:NamedThing pigment biosynthetic process The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. got7fsn_ti pigment synthesis|pigment formation|pigment biosynthesis|pigment anabolism biological_process owl:Class
GO:0007295 biolink:NamedThing growth of a germarium-derived egg chamber Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster. got7fsn_ti egg chamber growth biological_process owl:Class
GO:0048589 biolink:NamedThing developmental growth The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. got7fsn_ti biological_process owl:Class
GO:0072205 biolink:NamedThing metanephric collecting duct development The process whose specific outcome is the progression of a collecting duct in the metanephros over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder. got7fsn_ti mah 2010-03-18T11:15:37Z biological_process owl:Class
GO:0072044 biolink:NamedThing collecting duct development The process whose specific outcome is the progression of a collecting duct over time, from its formation to the mature structure. The collecting duct responds to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance. It is the final common path through which urine flows before entering the ureter and then emptying into the bladder. got7fsn_ti mah 2010-01-25T03:18:06Z biological_process owl:Class
GO:0001700 biolink:NamedThing embryonic development via the syncytial blastoderm The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0009792 biolink:NamedThing embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. got7fsn_ti embryogenesis biological_process owl:Class
GO:0009267 biolink:NamedThing cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. got7fsn_ti biological_process owl:Class
GO:0042594 biolink:NamedThing response to starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. got7fsn_ti biological_process owl:Class
GO:0014745 biolink:NamedThing negative regulation of muscle adaptation Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation. got7fsn_ti negative regulation of muscle plasticity biological_process owl:Class
GO:0048585 biolink:NamedThing negative regulation of response to stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. got7fsn_ti down-regulation of response to stimulus|inhibition of response to stimulus|downregulation of response to stimulus|down regulation of response to stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0047363 biolink:NamedThing triglucosylalkylacylglycerol sulfotransferase activity Catalysis of the reaction: alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + 3'-phosphoadenosine 5'-phosphosulfate = 6-sulfo-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,6-alpha-D-glucosyl-1,3-1-O-alkyl-2-O-acylglycerol + adenosine 3',5'-bisphosphate. got7fsn_ti triglucosylalkylacylglycerol sulphotransferase activity|3'-phosphoadenylyl-sulfate:triglucosyl-1-O-alkyl-2-O-acylglycerol 6-sulfotransferase activity|triglucosylmonoalkylmonoacyl sulfotransferase activity RHEA:13273|EC:2.8.2.19|MetaCyc:2.8.2.19-RXN molecular_function owl:Class
GO:0042771 biolink:NamedThing intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. got7fsn_ti DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis biological_process owl:Class
GO:0072332 biolink:NamedThing intrinsic apoptotic signaling pathway by p53 class mediator A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. got7fsn_ti intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator|signal transduction by p53 class mediator resulting in induction of apoptosis mah 2010-11-03T01:47:56Z biological_process owl:Class
GO:0140338 biolink:NamedThing sphingomyelin transfer activity Removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. got7fsn_ti sphingosine transmembrane transporter activity|sphingomyelin carrier activity pg 2019-05-16T11:31:58Z GO:0010175 molecular_function owl:Class
GO:0120013 biolink:NamedThing lipid transfer activity Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids. got7fsn_ti lipid carrier activity|intermembrane lipid transfer activity https://github.com/geneontology/go-ontology/issues/12329|https://github.com/geneontology/go-ontology/issues/17648 krc 2017-03-17T03:17:29Z molecular_function owl:Class
GO:0004134 biolink:NamedThing 4-alpha-glucanotransferase activity Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. got7fsn_ti D-enzyme activity|amylomaltase activity|oligo-1,4-1,4-glucantransferase activity|debranching enzyme maltodextrin glycosyltransferase activity|1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity|dextrin glycosyltransferase activity|disproportionating enzyme activity|dextrin transglycosylase activity Reactome:R-HSA-71552|MetaCyc:RXN-1828|MetaCyc:RXN-9023|EC:2.4.1.25|MetaCyc:AMYLOMALT-RXN molecular_function owl:Class
GO:0004133 biolink:NamedThing glycogen debranching enzyme activity Catalysis of the cleavage of branch points in branched glycogen polymers. got7fsn_ti molecular_function owl:Class
GO:0047747 biolink:NamedThing cholate-CoA ligase activity Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. got7fsn_ti choloyl coenzyme A synthetase activity|cholate thiokinase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity|cholic thiokinase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity|BAL activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity|trihydroxycoprostanoyl-CoA synthetase activity|bile acid CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity|cholyl-CoA synthetase activity|cholate:CoA ligase (AMP-forming)|cholic acid:CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity|3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity|bile acid coenzyme A ligase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)|choloyl-CoA synthetase activity|THCA-CoA ligase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity GO:0047477 EC:6.2.1.7|MetaCyc:CHOLATE--COA-LIGASE-RXN molecular_function owl:Class
GO:0060134 biolink:NamedThing prepulse inhibition The process in which a startle magnitude is reduced when the startling stimulus is preceded by a low-intensity prepulse. got7fsn_ti pre-pulse inhibition|PPI Wikipedia:Prepulse_inhibition biological_process owl:Class
GO:0032102 biolink:NamedThing negative regulation of response to external stimulus Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus. got7fsn_ti inhibition of response to external stimulus|downregulation of response to external stimulus|down-regulation of response to external stimulus|down regulation of response to external stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0043354 biolink:NamedThing enucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus. got7fsn_ti enucleate RBC maturation|enucleate red blood cell maturation biological_process owl:Class
GO:0043249 biolink:NamedThing erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state. got7fsn_ti red blood cell maturation|RBC maturation biological_process owl:Class
GO:0050320 biolink:NamedThing tartrate epimerase activity Catalysis of the reaction: L-tartrate = (2R,3S)-tartrate. got7fsn_ti tartaric racemase activity KEGG_REACTION:R02546|EC:5.1.2.5|MetaCyc:TARTRATE-EPIMERASE-RXN|RHEA:22212 molecular_function owl:Class
GO:0106267 biolink:NamedThing 3,5 dichloro-THPH synthase activity Catalysis of the reaction: (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + chloride + FADH2 + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O. got7fsn_ti hjd 2020-06-02T18:16:23Z RHEA:64360 molecular_function owl:Class
GO:0016712 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti flavoprotein-linked monooxygenase activity|cytochrome p450 activity|microsomal P-450|microsomal p450 activity|substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)|xenobiotic monooxygenase activity|unspecific monooxygenase activity|flavoprotein monooxygenase activity|microsomal monooxygenase activity|cytochrome P450 CYP19|aryl hydrocarbon hydroxylase activity|aryl-4-monooxygenase activity GO:0008402|GO:0050381 Reactome:R-HSA-211966|UM-BBD_enzymeID:e0551|EC:1.14.14.- molecular_function owl:Class
GO:0000331 biolink:NamedThing contractile vacuole A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. One of its functions is osmoregulatory. got7fsn_ti central bladder|central vacuole Wikipedia:Contractile_vacuole cellular_component owl:Class
GO:0005773 biolink:NamedThing vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. got7fsn_ti vacuolar carboxypeptidase Y Wikipedia:Vacuole cellular_component owl:Class
GO:0070444 biolink:NamedThing oligodendrocyte progenitor proliferation The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system. got7fsn_ti oligodendrocyte precursor proliferation biological_process owl:Class
GO:0061351 biolink:NamedThing neural precursor cell proliferation The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell. got7fsn_ti dph 2010-10-01T11:06:04Z biological_process owl:Class
GO:0042296 biolink:NamedThing ISG15 transferase activity Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages. got7fsn_ti ISG15 conjugating enzyme activity Reactome:R-HSA-5653754 molecular_function owl:Class
GO:0019787 biolink:NamedThing ubiquitin-like protein transferase activity Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein. got7fsn_ti small conjugating protein transferase activity|E3|small conjugating protein ligase activity|small protein conjugating enzyme activity|ubiquitin-like-protein ligase activity|ubiquitin-like conjugating enzyme activity|E2 GO:0008639|GO:0008640 Reactome:R-HSA-5678490|Reactome:R-HSA-688137 molecular_function owl:Class
GO:0030282 biolink:NamedThing bone mineralization The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. got7fsn_ti bone calcification biological_process owl:Class
GO:0031214 biolink:NamedThing biomineral tissue development Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation. got7fsn_ti Wikipedia:Biomineralization biological_process owl:Class
GO:0034387 biolink:NamedThing 4-aminobutyrate:pyruvate transaminase activity Catalysis of the reaction: 4-aminobutanoate + pyruvate = succinate semialdehyde + alanine. got7fsn_ti gamma-aminobutyric acid pyruvate transaminase activity MetaCyc:RXN-6902|RHEA:32263|EC:2.6.1.96 molecular_function owl:Class
GO:0003867 biolink:NamedThing 4-aminobutyrate transaminase activity Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid. got7fsn_ti beta-alanine aminotransferase|gamma-aminobutyric transaminase activity|aminobutyrate transaminase activity|GABA aminotransferase activity|GABA transferase activity|gamma-aminobutyric acid aminotransferase activity|glutamate-succinic semialdehyde transaminase activity|aminobutyrate aminotransferase activity|gamma-amino-N-butyrate transaminase activity|4-aminobutyrate aminotransferase activity|4-aminobutanoate transaminase activity|gamma-aminobutyrate transaminase activity|4-aminobutyric acid aminotransferase activity|gamma-aminobutyrate aminotransaminase activity|gamma-aminobutyric acid transaminase activity|GABA transaminase activity RHEA:23352|Reactome:R-HSA-916855|MetaCyc:GABATRANSAM-RXN molecular_function owl:Class
GO:0042165 biolink:NamedThing neurotransmitter binding Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. got7fsn_ti molecular_function owl:Class
GO:0005488 biolink:NamedThing binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. got7fsn_ti ligand Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. Wikipedia:Binding_(molecular) molecular_function owl:Class
GO:0050083 biolink:NamedThing malyl-CoA lyase activity Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate. got7fsn_ti (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming)|malyl-coenzyme A lyase activity|(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase activity MetaCyc:MALYL-COA-LYASE-RXN|EC:4.1.3.24|RHEA:16629 molecular_function owl:Class
GO:0016833 biolink:NamedThing oxo-acid-lyase activity Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. got7fsn_ti oxo-acid lyase activity|oxoacid lyase activity EC:4.1.3.- molecular_function owl:Class
GO:0050290 biolink:NamedThing sphingomyelin phosphodiesterase D activity Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+). got7fsn_ti sphingomyelinase D|sphingomyelin ceramide-phosphohydrolase activity MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-D-RXN|EC:3.1.4.41|RHEA:20984|KEGG_REACTION:R02542 molecular_function owl:Class
GO:0008081 biolink:NamedThing phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. got7fsn_ti phosphodiesterase GO:0004434|GO:0016792 EC:3.1.4.-|Reactome:R-HSA-5693578 molecular_function owl:Class
GO:0002450 biolink:NamedThing B cell antigen processing and presentation The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti B-cell antigen processing and presentation|B lymphocyte antigen processing and presentation|B-lymphocyte antigen processing and presentation biological_process owl:Class
GO:1902761 biolink:NamedThing positive regulation of chondrocyte development Any process that activates or increases the frequency, rate or extent of chondrocyte development. got7fsn_ti upregulation of chondrocyte development|up regulation of chondrocyte development|up-regulation of chondrocyte development|activation of chondrocyte development mr 2014-03-07T17:45:55Z biological_process owl:Class
GO:0061181 biolink:NamedThing regulation of chondrocyte development Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. got7fsn_ti dph 2010-07-14T08:28:52Z biological_process owl:Class
GO:0010476 biolink:NamedThing gibberellin mediated signaling pathway The series of molecular signals generated as a consequence of gibberellin stimulus. got7fsn_ti gibberellin-mediated signalling biological_process owl:Class
GO:0009755 biolink:NamedThing hormone-mediated signaling pathway A series of molecular signals mediated by the detection of a hormone. got7fsn_ti hormone mediated signalling biological_process owl:Class
GO:0010098 biolink:NamedThing suspensor development The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm. got7fsn_ti biological_process owl:Class
GO:0047837 biolink:NamedThing D-xylose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-xylose + NADP(+) = D-xylono-1,5-lactone + H(+) + NADPH. got7fsn_ti D-xylose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|D-xylose:NADP+ 1-oxidoreductase activity|D-xylose:NADP+ oxidoreductase activity|D-xylose-NADP dehydrogenase activity MetaCyc:D-XYLOSE-1-DEHYDROGENASE-NADP+-RXN|RHEA:22000|EC:1.1.1.179|KEGG_REACTION:R01430 molecular_function owl:Class
GO:0102931 biolink:NamedThing (Z,E)-alpha- farnesene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z,E)-alpha-farnesene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8931 molecular_function owl:Class
GO:0014902 biolink:NamedThing myotube differentiation The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. got7fsn_ti biological_process owl:Class
GO:0051146 biolink:NamedThing striated muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle. got7fsn_ti voluntary muscle cell differentiation biological_process owl:Class
GO:0000702 biolink:NamedThing oxidized base lesion DNA N-glycosylase activity Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. got7fsn_ti molecular_function owl:Class
GO:0052880 biolink:NamedThing oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein. got7fsn_ti EC:1.10.9.- molecular_function owl:Class
GO:0016679 biolink:NamedThing oxidoreductase activity, acting on diphenols and related substances as donors Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors EC:1.10.-.- molecular_function owl:Class
GO:1990692 biolink:NamedThing trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. got7fsn_ti trans-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane bhm 2015-03-12T09:54:02Z biological_process owl:Class
GO:0048210 biolink:NamedThing Golgi vesicle fusion to target membrane The joining of the lipid bilayer membrane around a Golgi transport vesicle to the target lipid bilayer membrane. got7fsn_ti dictyosome vesicle fusion to target membrane|Golgi-derived vesicle fusion to target membrane biological_process owl:Class
GO:0015638 biolink:NamedThing microcin transmembrane transporter activity Enables the transfer of a microcin from one side of a membrane to the other. got7fsn_ti microcin uptake permease activity molecular_function owl:Class
GO:0042910 biolink:NamedThing xenobiotic transmembrane transporter activity Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti multidrug, alkane resistant pump activity|multidrug efflux pump activity|drug transmembrane transporter activity|drug transporter activity|multidrug transporter activity|xenobiotic transporter activity https://github.com/geneontology/go-ontology/issues/19460 GO:0015559|GO:0015564|GO:0090484|GO:0015238|GO:0015239 molecular_function owl:Class
GO:0016641 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. got7fsn_ti EC:1.4.3.- molecular_function owl:Class
GO:0016638 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors EC:1.4.-.- molecular_function owl:Class
GO:0016054 biolink:NamedThing organic acid catabolic process The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage. got7fsn_ti organic acid degradation|organic acid catabolism|organic acid breakdown biological_process owl:Class
GO:0006082 biolink:NamedThing organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. got7fsn_ti organic acid metabolism biological_process owl:Class
GO:0070043 biolink:NamedThing rRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine. got7fsn_ti Reactome:R-HSA-6790982 molecular_function owl:Class
GO:1990834 biolink:NamedThing response to odorant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell. got7fsn_ti sl 2015-08-21T18:51:52Z biological_process owl:Class
GO:0042221 biolink:NamedThing response to chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. got7fsn_ti response to chemical stimulus|response to chemical substance Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0005145 biolink:NamedThing interleukin-14 receptor binding Binding to an interleukin-14 receptor. got7fsn_ti IL-14|interleukin-14 receptor ligand molecular_function owl:Class
GO:0021521 biolink:NamedThing ventral spinal cord interneuron specification The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway. got7fsn_ti biological_process owl:Class
GO:0048665 biolink:NamedThing neuron fate specification The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0030588 biolink:NamedThing pseudocleavage Partial constriction of the cytoplasm of a cell to form a furrow that resembles a cleavage furrow but does not complete cytokinesis. got7fsn_ti biological_process owl:Class
GO:0038060 biolink:NamedThing nitric oxide-cGMP-mediated signaling pathway Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP. got7fsn_ti canonical nitric oxide signaling|NO-cGMP signaling pathway|classical nitric oxide signaling|nitric oxide-cGMP-mediated signalling pathway bf 2012-01-10T05:32:39Z biological_process owl:Class
GO:0007263 biolink:NamedThing nitric oxide mediated signal transduction Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. got7fsn_ti nitric oxide-mediated signal transduction|NO-mediated signal transduction|nitric oxide signaling|NO mediated signal transduction biological_process owl:Class
GO:0050594 biolink:NamedThing tabersonine 16-hydroxylase activity Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+). got7fsn_ti tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating) MetaCyc:1.14.13.73-RXN|EC:1.14.14.103|KEGG_REACTION:R05855|RHEA:14133 molecular_function owl:Class
GO:0009418 biolink:NamedThing pilus shaft The long, slender, mid section of a pilus. got7fsn_ti fimbrial shaft cellular_component owl:Class
GO:0021623 biolink:NamedThing oculomotor nerve formation The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. got7fsn_ti CN III biosynthesis|CN III formation biological_process owl:Class
GO:0021603 biolink:NamedThing cranial nerve formation The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti biological_process owl:Class
GO:0003209 biolink:NamedThing cardiac atrium morphogenesis The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. got7fsn_ti dph 2009-10-13T09:39:44Z biological_process owl:Class
GO:1990117 biolink:NamedThing B cell receptor apoptotic signaling pathway An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell. got7fsn_ti B cell receptor extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway via BCR|extrinsic apoptotic signaling pathway via B cell antigen receptor pr 2013-06-06T15:15:17Z biological_process owl:Class
GO:0035771 biolink:NamedThing interleukin-4-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-4-mediated signalling pathway|IL-4-mediated signaling pathway bf 2011-04-01T10:56:46Z biological_process owl:Class
GO:0044809 biolink:NamedThing chemokine (C-C motif) ligand 17 production The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CCL17 production|thymus and activation regulated chemokine production|TARC production jl 2013-09-11T12:21:31Z biological_process owl:Class
GO:0032602 biolink:NamedThing chemokine production The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. got7fsn_ti chemokine synthesis|chemokine biosynthetic process|chemokine secretion|chemokine anabolism|chemokine formation|chemokine biosynthesis|chemokine metabolic process 2009-12-18T11:26:20Z GO:0090195|GO:0042033|GO:0050755 biological_process owl:Class
GO:0036501 biolink:NamedThing UFD1-NPL4 complex A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p. got7fsn_ti Npl4p-Ufd1p complex|Ufd1/Npl4 complex|UFD1L-NPLOC4 complex|Ufd1-Npl4 cofactor complex|Ufd1-Npl4 binary complex bf 2015-05-14T10:59:43Z cellular_component owl:Class
GO:0071417 biolink:NamedThing cellular response to organonitrogen compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. got7fsn_ti cellular response to organic nitrogen mah 2009-12-14T04:07:27Z biological_process owl:Class
GO:0071495 biolink:NamedThing cellular response to endogenous stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. mah 2009-12-18T02:25:40Z biological_process owl:Class
GO:0106017 biolink:NamedThing phosphatidylinositol-3,4-bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. got7fsn_ti hjd 2017-05-10T14:08:06Z molecular_function owl:Class
GO:0034593 biolink:NamedThing phosphatidylinositol bisphosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol bisphosphate + H2O = phosphatidylinositol phosphate + phosphate. got7fsn_ti triphosphoinositide phosphomonoesterase activity|diphosphoinositide phosphatase activity|phosphatidylinositol-bisphosphatase activity|triphosphoinositide phosphatase activity|phosphatidyl-inositol-bisphosphate phosphatase activity molecular_function owl:Class
GO:0046889 biolink:NamedThing positive regulation of lipid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. got7fsn_ti up regulation of lipid biosynthetic process|positive regulation of lipogenesis|stimulation of lipid biosynthetic process|activation of lipid biosynthetic process|positive regulation of lipid synthesis|up-regulation of lipid biosynthetic process|positive regulation of lipid formation|positive regulation of lipid biosynthesis|upregulation of lipid biosynthetic process|positive regulation of lipid anabolism biological_process owl:Class
GO:0046890 biolink:NamedThing regulation of lipid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. got7fsn_ti regulation of lipid formation|regulation of lipogenesis|regulation of lipid biosynthesis|regulation of lipid synthesis|regulation of lipid anabolism biological_process owl:Class
GO:0031434 biolink:NamedThing mitogen-activated protein kinase kinase binding Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase. got7fsn_ti MAPKK binding molecular_function owl:Class
GO:0019901 biolink:NamedThing protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. got7fsn_ti molecular_function owl:Class
GO:0022852 biolink:NamedThing glycine-gated chloride ion channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts. got7fsn_ti molecular_function owl:Class
GO:0022824 biolink:NamedThing transmitter-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. got7fsn_ti ionotropic neurotransmitter receptor activity molecular_function owl:Class
GO:0010445 biolink:NamedThing nuclear dicing body A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes. got7fsn_ti D body cellular_component owl:Class
GO:0016604 biolink:NamedThing nuclear body Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. got7fsn_ti NIF_Subcellular:sao505137457 cellular_component owl:Class
GO:0034554 biolink:NamedThing 3,3',5-tribromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3,3',5-tribromobisphenol A + 2 H+ + 2 e- = 3,3'-dibromobisphenol A + HBr. got7fsn_ti UM-BBD_reactionID:r0842|EC:1.97.1.- molecular_function owl:Class
GO:1990864 biolink:NamedThing response to growth hormone-releasing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins. got7fsn_ti response to sermorelin|response to somatoliberin|response to somatorelin|response to GHRF|response to GRF|response to somatocrinin|response to growth hormone-releasing factor sl 2015-09-25T14:45:31Z biological_process owl:Class
GO:0009163 biolink:NamedThing nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). got7fsn_ti nucleoside formation|nucleoside synthesis|nucleoside biosynthesis|nucleoside anabolism biological_process owl:Class
GO:0034404 biolink:NamedThing nucleobase-containing small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. got7fsn_ti nucleobase, nucleoside and nucleotide formation|nucleobase, nucleoside and nucleotide biosynthesis|nucleobase, nucleoside and nucleotide anabolism|nucleobase, nucleoside and nucleotide synthesis biological_process owl:Class
GO:0097435 biolink:NamedThing supramolecular fiber organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. got7fsn_ti fibril organization|extracellular fibril organization|fibril organisation|extracellular fibril organization and biogenesis|extracellular fibril organisation pr 2012-11-27T15:46:25Z GO:0043206 biological_process owl:Class
GO:0016043 biolink:NamedThing cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. got7fsn_ti cellular component organization at cellular level|cellular component organisation in other organism|cell organization and biogenesis|cellular component organisation at cellular level|cellular component organization in other organism|cell organisation GO:0044235|GO:0071842 biological_process owl:Class
GO:0061521 biolink:NamedThing hepatic stellate cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell. got7fsn_ti dph 2013-04-18T13:36:08Z biological_process owl:Class
GO:0018218 biolink:NamedThing peptidyl-cysteine phosphorylation The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine. got7fsn_ti RESID:AA0034 biological_process owl:Class
GO:1990315 biolink:NamedThing Mcs4 RR-MAPKKK complex A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress. got7fsn_ti In S. pombe it consists of Mpr1, Tdh1, Mcs4, Win1, Wis4 and Wis1. al 2014-03-14T09:59:45Z cellular_component owl:Class
GO:0099589 biolink:NamedThing serotonin receptor activity Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. got7fsn_ti molecular_function owl:Class
GO:0050740 biolink:NamedThing protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-threonine. got7fsn_ti RESID:AA0349 biological_process owl:Class
GO:0060407 biolink:NamedThing negative regulation of penile erection Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. got7fsn_ti biological_process owl:Class
GO:0015049 biolink:NamedThing methane monooxygenase activity Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O. got7fsn_ti methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)|methane hydroxylase activity UM-BBD_enzymeID:e0007|KEGG_REACTION:R01143|MetaCyc:METHANE-MONOOXYGENASE-RXN|EC:1.14.13.25|KEGG_REACTION:R01142 molecular_function owl:Class
GO:0009727 biolink:NamedThing detection of ethylene stimulus The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of ethene stimulus|perception of ethylene stimulus|detection of ethene stimulus biological_process owl:Class
GO:0009723 biolink:NamedThing response to ethylene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. got7fsn_ti response to ethylene stimulus|response to ethene stimulus biological_process owl:Class
GO:0036176 biolink:NamedThing response to neutral pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti bf 2012-03-29T01:38:00Z biological_process owl:Class
GO:0046780 biolink:NamedThing suppression by virus of host mRNA splicing Any viral process that inhibits the splicing of host mRNA, thus reducing host protein production. got7fsn_ti suppression by virus of host splicing factor activity|viral inhibition of host mRNA splicing|negative regulation by virus of host mRNA splicing|viral dispersion of host splicing factors GO:0046781 biological_process owl:Class
GO:0033119 biolink:NamedThing negative regulation of RNA splicing Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing. got7fsn_ti biological_process owl:Class
GO:0097478 biolink:NamedThing leaflet of membrane bilayer Any of the two layers of lipid molecules that constitute a membrane. got7fsn_ti membrane leaflet pr 2013-05-07T14:24:37Z cellular_component owl:Class
GO:0061303 biolink:NamedThing cornea development in camera-type eye The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye. got7fsn_ti dph 2010-09-14T02:09:08Z biological_process owl:Class
GO:0061150 biolink:NamedThing renal system segmentation The regionalization process that divides an the renal system into a series of segments along its proximal/distal axis. got7fsn_ti urinary tract segmentation dph 2010-06-02T09:23:01Z biological_process owl:Class
GO:0080173 biolink:NamedThing male-female gamete recognition during double fertilization forming a zygote and endosperm The initial contact step made between the male gamete and the female gamete during double fertilization forming a zygote and endosperm. An example can be found in Arabidopsis thaliana. got7fsn_ti gamete recognition|male-female gamete recognition dhl 2011-04-26T04:58:58Z biological_process owl:Class
GO:0009988 biolink:NamedThing cell-cell recognition Cell recognition between cells. May involve the formation of specialized cell junctions. got7fsn_ti biological_process owl:Class
GO:0043849 biolink:NamedThing Ras palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins. got7fsn_ti Ras protein acyltransferase activity|DHHC cysteine-rich domain-containing protein ERF2|palmitoyltransferase ERF2|ERF2 molecular_function owl:Class
GO:0019706 biolink:NamedThing protein-cysteine S-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]. got7fsn_ti protein-cysteine S-palmitoleyltransferase activity EC:2.3.1.225|RHEA:36683|Reactome:R-HSA-9647982|Reactome:R-HSA-5682084|Reactome:R-HSA-9021072 molecular_function owl:Class
GO:0018096 biolink:NamedThing peptide cross-linking via S-(2-aminovinyl)-D-cysteine The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine. got7fsn_ti RESID:AA0204 biological_process owl:Class
GO:0045196 biolink:NamedThing establishment or maintenance of neuroblast polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. got7fsn_ti establishment and/or maintenance of neuroblast cell polarity GO:0043342|GO:0043339 biological_process owl:Class
GO:0007163 biolink:NamedThing establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns. got7fsn_ti cell polarity|establishment and/or maintenance of cell polarity|establishment and/or maintenance of cell polarization GO:0030467|GO:0030012 biological_process owl:Class
GO:0035907 biolink:NamedThing dorsal aorta development The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:07:01Z biological_process owl:Class
GO:0035904 biolink:NamedThing aorta development The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body. got7fsn_ti bf 2011-06-24T11:00:07Z biological_process owl:Class
GO:0003858 biolink:NamedThing 3-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH. got7fsn_ti D-beta-hydroxybutyrate dehydrogenase activity MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN|EC:1.1.1.30|KEGG_REACTION:R01361|Reactome:R-HSA-73920|Reactome:R-HSA-73912|Reactome:R-HSA-5696457|RHEA:20521 molecular_function owl:Class
GO:0051337 biolink:NamedThing amitosis Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation. got7fsn_ti Remak nuclear division|direct nuclear division biological_process owl:Class
GO:0000280 biolink:NamedThing nuclear division The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. got7fsn_ti karyokinesis biological_process owl:Class
GO:0007377 biolink:NamedThing germ-band extension Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further. got7fsn_ti biological_process owl:Class
GO:0048598 biolink:NamedThing embryonic morphogenesis The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. got7fsn_ti embryonic anatomical structure morphogenesis GO:0048828 biological_process owl:Class
GO:2000195 biolink:NamedThing negative regulation of female gonad development Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development. got7fsn_ti negative regulation of ovary development|negative regulation of ovarian development yaf 2010-10-19T10:45:38Z biological_process owl:Class
GO:0051093 biolink:NamedThing negative regulation of developmental process Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). got7fsn_ti downregulation of developmental process|inhibition of developmental process|down regulation of developmental process|down-regulation of developmental process biological_process owl:Class
GO:0060472 biolink:NamedThing positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration Any process that activates or increases the frequency, rate or extent of cortical granule exocytosis by directing movement of calcium ions (Ca2+) into the cytosol. got7fsn_ti positive regulation of cortical granule exocytosis by elevation of cytosolic calcium ion concentration biological_process owl:Class
GO:0045956 biolink:NamedThing positive regulation of calcium ion-dependent exocytosis Any process that activates or increases the frequency, rate or extent of calcium ion-dependent exocytosis. got7fsn_ti up regulation of calcium ion-dependent exocytosis|activation of calcium ion-dependent exocytosis|up-regulation of calcium ion-dependent exocytosis|upregulation of calcium ion-dependent exocytosis|stimulation of calcium ion-dependent exocytosis biological_process owl:Class
GO:0031803 biolink:NamedThing type 6 metabotropic glutamate receptor binding Binding to a type 6 metabotropic glutamate receptor. got7fsn_ti type 6 metabotropic glutamate receptor ligand molecular_function owl:Class
GO:0035256 biolink:NamedThing G protein-coupled glutamate receptor binding Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor). got7fsn_ti metabotropic glutamate receptor binding|G-protein coupled glutamate receptor binding molecular_function owl:Class
GO:0102063 biolink:NamedThing beta-curcumene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (-)-beta-curcumene. got7fsn_ti MetaCyc:RXN-10598 molecular_function owl:Class
GO:0003417 biolink:NamedThing growth plate cartilage development The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow. got7fsn_ti dph 2009-12-22T08:57:42Z biological_process owl:Class
GO:0060351 biolink:NamedThing cartilage development involved in endochondral bone morphogenesis The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. got7fsn_ti biological_process owl:Class
GO:0035888 biolink:NamedThing isoguanine deaminase activity Catalysis of the reaction: isoguanine + H2O = xanthine + NH3. got7fsn_ti 2-oxoadenine deaminase activity|2-hydroxyadenine deaminase activity bf 2011-06-14T02:15:53Z molecular_function owl:Class
GO:1901991 biolink:NamedThing negative regulation of mitotic cell cycle phase transition Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition. got7fsn_ti downregulation of mitotic cell cycle phase transition|inhibition of mitotic cell cycle phase transition|down regulation of mitotic cell cycle phase transition|down-regulation of mitotic cell cycle phase transition jl 2013-03-19T16:14:46Z biological_process owl:Class
GO:0098622 biolink:NamedThing selenodiglutathione-disulfide reductase activity Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+. got7fsn_ti RHEA:34927|Reactome:R-HSA-2408542 molecular_function owl:Class
GO:0015036 biolink:NamedThing disulfide oxidoreductase activity Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. got7fsn_ti disulphide oxidoreductase activity Reactome:R-HSA-1222417|Reactome:R-HSA-1222644|Reactome:R-HSA-264997|Reactome:R-HSA-1222690|Reactome:R-HSA-1222655 molecular_function owl:Class
GO:0071278 biolink:NamedThing cellular response to cesium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. got7fsn_ti cellular response to cesium mah 2009-12-10T03:55:44Z biological_process owl:Class
GO:0010164 biolink:NamedThing response to cesium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus. got7fsn_ti response to cesium biological_process owl:Class
GO:0014001 biolink:NamedThing sclerenchyma cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable. got7fsn_ti biological_process owl:Class
GO:0052104 biolink:NamedThing induction by symbiont of host systemic acquired resistance Any process in which a symbiont activates systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti activation by organism of SAR in host|induction by organism of systemic acquired resistance in other organism involved in symbiotic interaction|activation by organism of systemic acquired resistance in host|up regulation by symbiont of systemic acquired resistance in host|positive regulation by symbiont of systemic acquired resistance in host|upregulation by symbiont of systemic acquired resistance in host|positive regulation by symbiont of host systemic acquired resistance|induction by symbiont of systemic acquired resistance in host|stimulation by symbiont of systemic acquired resistance in host|up-regulation by symbiont of systemic acquired resistance in host|positive regulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction|induction by organism of SAR in host GO:0052535|GO:0052537|GO:0052289 biological_process owl:Class
GO:0052160 biolink:NamedThing modulation by symbiont of host systemic acquired resistance Any process in which a symbiont modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of systemic acquired resistance in other organism involved in symbiotic interaction|modulation by symbiont of systemic acquired resistance in host GO:0052299 biological_process owl:Class
GO:0019799 biolink:NamedThing tubulin N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine. got7fsn_ti acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity|alpha-tubulin acetyltransferase activity|alpha-tubulin N-acetyltransferase activity|alpha-tubulin acetylase activity|acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity|TAT activity|tubulin acetyltransferase activity|acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN|RHEA:15277|EC:2.3.1.108 molecular_function owl:Class
GO:0061733 biolink:NamedThing peptide-lysine-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. got7fsn_ti dph 2015-09-10T10:22:19Z Reactome:R-HSA-9620515|Reactome:R-HSA-9617758|Reactome:R-HSA-9626945|Reactome:R-HSA-8951966|Reactome:R-HSA-6811508 molecular_function owl:Class
GO:0070078 biolink:NamedThing histone H3-R2 demethylation The modification of histone H3 by the removal of a methyl group from arginine at position 2 of the histone. got7fsn_ti biological_process owl:Class
GO:0070077 biolink:NamedThing histone arginine demethylation The modification of a histone by the removal of a methyl group from an arginine residue. got7fsn_ti biological_process owl:Class
GO:0045184 biolink:NamedThing establishment of protein localization The directed movement of a protein to a specific location. got7fsn_ti establishment of protein localisation|protein recruitment|protein positioning biological_process owl:Class
GO:0051234 biolink:NamedThing establishment of localization Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. got7fsn_ti establishment of localisation biological_process owl:Class
GO:0022871 biolink:NamedThing protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti sorbose PTS transporter activity https://github.com/geneontology/go-ontology/issues/17289 EC:2.7.1.206|RHEA:49296 molecular_function owl:Class
GO:0019194 biolink:NamedThing sorbose transmembrane transporter activity Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid. got7fsn_ti sorbose porter activity GO:0019193 molecular_function owl:Class
GO:0071357 biolink:NamedThing cellular response to type I interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti cellular response to type I IFN mah 2009-12-11T02:51:47Z biological_process owl:Class
GO:0034340 biolink:NamedThing response to type I interferon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti response to type I IFN biological_process owl:Class
GO:0102169 biolink:NamedThing pyocyanin hydroxylase activity Catalysis of the reaction: 5-methylphenazine-1-carboxylate + NADH + O2 + 2 H+ <=> pyocyanin + NAD + carbon dioxide + H2O. got7fsn_ti MetaCyc:RXN-11898|RHEA:48976 molecular_function owl:Class
GO:0052249 biolink:NamedThing modulation of RNA levels in other organism involved in symbiotic interaction The alteration by an organism of the levels of RNA in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modulation of RNA levels in other organism during symbiotic interaction biological_process owl:Class
GO:0051817 biolink:NamedThing modulation of process of other organism involved in symbiotic interaction The process in which an organism effects a change in the structure or processes of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti regulation of physiology of other organism during symbiotic interaction|regulation of morphology of other organism during symbiotic interaction|modification of morphology or physiology of other organism involved in symbiotic interaction|regulation of physiological process in other organism during symbiotic interaction|modulation of morphology or physiology of other organism during symbiotic interaction|regulation of morphology or physiology of other organism during symbiotic interaction|modification of morphology or physiology of other organism during symbiotic interaction|modulation of biological process of other organism involved in symbiotic interaction https://github.com/geneontology/go-ontology/issues/18605 biological_process owl:Class
GO:0051660 biolink:NamedThing establishment of centrosome localization The directed movement of the centrosome to a specific location. got7fsn_ti establishment of centrosome localisation|centrosome positioning biological_process owl:Class
GO:0051649 biolink:NamedThing establishment of localization in cell Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. got7fsn_ti establishment of intracellular localization|positioning within cell|establishment of localization within cell|establishment of localisation in cell|establishment of cellular localization biological_process owl:Class
GO:0033763 biolink:NamedThing proline 3-hydroxylase activity Catalysis of the reaction: L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2. got7fsn_ti P-3-H|L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity RHEA:20265|EC:1.14.11.28|MetaCyc:1.14.11.28-RXN molecular_function owl:Class
GO:0018650 biolink:NamedThing styrene monooxygenase activity Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide. got7fsn_ti UM-BBD_reactionID:r0225|EC:1.14.13.- molecular_function owl:Class
GO:0005360 biolink:NamedThing insulin-responsive glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. got7fsn_ti insulin-responsive hydrogen:glucose transporter activity|transepithelial hydrogen/glucose transporter activity|insulin-responsive hydrogen:glucose symporter activity molecular_function owl:Class
GO:0005356 biolink:NamedThing glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. got7fsn_ti hydrogen:glucose transporter activity|transepithelial hydrogen:glucose symporter activity|transepithelial hydrogen:glucose transporter activity|hydrogen:glucose symporter activity|transepithelial hydrogen/glucose transporter activity GO:0005361 molecular_function owl:Class
GO:0021564 biolink:NamedThing vagus nerve development The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. got7fsn_ti cranial nerve X development|cranial nerve 10 development|CN X development biological_process owl:Class
GO:0021545 biolink:NamedThing cranial nerve development The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti biological_process owl:Class
GO:1990571 biolink:NamedThing meiotic centromere clustering The process by which centromeres/kinetochores attach to and migrate along microtubules to become localized to clusters at the spindle pole body during a meiotic prometaphase I. got7fsn_ti centromere clustering during meiosis|homologous chromosome movement towards spindle pole in meiosis I prometaphase mah 2014-12-02T11:25:37Z biological_process owl:Class
GO:0016344 biolink:NamedThing meiotic chromosome movement towards spindle pole The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis. got7fsn_ti chromosome movement towards spindle pole during meiosis|meiotic chromosome movement|chromosome migration to spindle pole during meiosis|meiotic chromosome movement to spindle pole biological_process owl:Class
GO:2000945 biolink:NamedThing regulation of amylopectin catabolic process Any process that modulates the frequency, rate or extent of amylopectin catabolic process. got7fsn_ti regulation of Amylopectin catabolism tt 2011-08-01T02:15:22Z biological_process owl:Class
GO:0031329 biolink:NamedThing regulation of cellular catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. got7fsn_ti regulation of cellular degradation|regulation of cellular catabolism|regulation of cellular breakdown biological_process owl:Class
GO:0007157 biolink:NamedThing heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell. got7fsn_ti agglutination biological_process owl:Class
GO:0051994 biolink:NamedThing P-methyltransferase activity Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule. got7fsn_ti ai 2010-07-16T04:39:34Z EC:2.1.1.- molecular_function owl:Class
GO:0030289 biolink:NamedThing protein phosphatase 4 complex A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits. got7fsn_ti cellular_component owl:Class
GO:0007527 biolink:NamedThing adult somatic muscle development The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0007525 biolink:NamedThing somatic muscle development The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle. got7fsn_ti biological_process owl:Class
GO:0030410 biolink:NamedThing nicotianamine synthase activity Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine. got7fsn_ti S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity EC:2.5.1.43|KEGG_REACTION:R00075|MetaCyc:2.5.1.43-RXN|RHEA:16481 molecular_function owl:Class
GO:0047220 biolink:NamedThing galactosylxylosylprotein 3-beta-galactosyltransferase activity Catalysis of the reaction: 4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP-galactose = 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein + UDP. got7fsn_ti galactosyltransferase II activity|uridine diphosphogalactose-galactosylxylose galactosyltransferase activity|UDPgalactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity|UDP-galactose:4-beta-D-galactosyl-O-beta-D-xylosylprotein 3-beta-D-galactosyltransferase activity RHEA:11780|Reactome:R-HSA-1889978|MetaCyc:2.4.1.134-RXN|Reactome:R-HSA-4420365|EC:2.4.1.134 molecular_function owl:Class
GO:0043844 biolink:NamedThing ADP-specific phosphofructokinase activity Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate. got7fsn_ti ADP:D-fructose-6-phosphate 1-phosphotransferase activity|ADP-dependent phosphofructokinase activity|ADP-6-phosphofructokinase activity|ADP-Pfk activity EC:2.7.1.146|RHEA:20105 molecular_function owl:Class
GO:0016773 biolink:NamedThing phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). got7fsn_ti Reactome:R-HSA-2161193|EC:2.7.1.- molecular_function owl:Class
GO:0102447 biolink:NamedThing rhamnetin 3'-O-methyltransferase activity Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 7,3'-dimethylquercetin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-13933 molecular_function owl:Class
GO:0070941 biolink:NamedThing eisosome assembly The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane. got7fsn_ti mah 2009-09-30T02:49:30Z biological_process owl:Class
GO:0022607 biolink:NamedThing cellular component assembly The aggregation, arrangement and bonding together of a cellular component. got7fsn_ti cellular component assembly at cellular level|cell structure assembly GO:0071844 biological_process owl:Class
GO:0002477 biolink:NamedThing antigen processing and presentation of exogenous peptide antigen via MHC class Ib The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti exogenous peptide antigen processing and presentation via MHC class Ib biological_process owl:Class
GO:0002478 biolink:NamedThing antigen processing and presentation of exogenous peptide antigen The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. got7fsn_ti exogenous peptide antigen processing and presentation biological_process owl:Class
GO:0016925 biolink:NamedThing protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. got7fsn_ti Smt3-protein conjugation|small ubiquitin-related protein 1 conjugation|protein sumolation|SUMO-protein conjugation|sumoylation|Smt3p-protein conjugation GO:0016927|GO:0006485|GO:0019951|GO:0019947 Wikipedia:SUMO_protein biological_process owl:Class
GO:0032446 biolink:NamedThing protein modification by small protein conjugation A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein. got7fsn_ti biological_process owl:Class
GO:0061541 biolink:NamedThing rhabdomere morphogenesis The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. got7fsn_ti dph 2013-06-24T07:59:25Z biological_process owl:Class
GO:0048812 biolink:NamedThing neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. got7fsn_ti neurite formation|neurite morphogenesis|neurite growth|neurite biosynthesis biological_process owl:Class
GO:0044753 biolink:NamedThing amphisome Intermediate organelles formed during macroautophagy through the fusion between autophagosomes and endosomes. got7fsn_ti jl 2012-11-27T15:35:25Z cellular_component owl:Class
GO:0005776 biolink:NamedThing autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. got7fsn_ti initial autophagic vacuole|autophagic vacuole NIF_Subcellular:sao8663416959 cellular_component owl:Class
GO:0042404 biolink:NamedThing thyroid hormone catabolic process The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. got7fsn_ti thyroid hormone breakdown|thyroid hormone catabolism|thyroid hormone degradation biological_process owl:Class
GO:0042219 biolink:NamedThing cellular modified amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents. got7fsn_ti cellular amino acid derivative catabolism|cellular modified amino acid breakdown|cellular amino acid derivative degradation|cellular modified amino acid catabolism|cellular modified amino acid degradation|modified amino acid catabolic process|cellular amino acid derivative catabolic process|amino acid derivative catabolic process|modified amino acid catabolism|cellular amino acid derivative breakdown biological_process owl:Class
GO:0060920 biolink:NamedThing cardiac pacemaker cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. got7fsn_ti pacemaker cell differentiation dph 2009-09-29T11:01:31Z biological_process owl:Class
GO:0055007 biolink:NamedThing cardiac muscle cell differentiation The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. got7fsn_ti cardiomyocyte differentiation|heart muscle cell differentiation biological_process owl:Class
GO:0009626 biolink:NamedThing plant-type hypersensitive response The rapid, localized death of plant cells in response to invasion by a pathogen. got7fsn_ti plant hypersensitive response|HR-PCD|HR Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. biological_process owl:Class
GO:0052848 biolink:NamedThing inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+. got7fsn_ti ai 2011-12-05T11:02:23Z MetaCyc:RXN-10976 molecular_function owl:Class
GO:0052841 biolink:NamedThing inositol bisdiphosphate tetrakisphosphate diphosphatase activity Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate. got7fsn_ti ai 2011-11-29T04:14:22Z Reactome:R-HSA-1855165|Reactome:R-HSA-2023973 molecular_function owl:Class
GO:0038137 biolink:NamedThing ERBB4-EGFR signaling pathway A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti HER1-HER4 signaling pathway|ERBB1-ERBB4 signaling pathway|ERBB4-EGFR signalling pathway bf 2012-03-30T11:30:30Z biological_process owl:Class
GO:0007173 biolink:NamedThing epidermal growth factor receptor signaling pathway A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti ERBB1 signaling pathway|EGF receptor signalling pathway|EGF receptor signaling pathway|EGFR signaling pathway|receptor tyrosine-protein kinase erbB-1 signaling pathway|epidermal growth factor receptor signalling pathway biological_process owl:Class
GO:0090032 biolink:NamedThing negative regulation of steroid hormone biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. got7fsn_ti tb 2009-08-03T10:41:35Z biological_process owl:Class
GO:0032353 biolink:NamedThing negative regulation of hormone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. got7fsn_ti down regulation of hormone biosynthetic process|downregulation of hormone biosynthetic process|inhibition of hormone biosynthetic process|down-regulation of hormone biosynthetic process biological_process owl:Class
GO:0102879 biolink:NamedThing (+)-thujopsene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-thujopsene + diphosphoric acid. got7fsn_ti RHEA:30375|EC:4.2.3.79|MetaCyc:RXN-8418 molecular_function owl:Class
GO:0060436 biolink:NamedThing bronchiole morphogenesis The process in which a bronchiole is generated and organized. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. got7fsn_ti biological_process owl:Class
GO:0033749 biolink:NamedThing histone H3-methyl-arginine-3 demethylase activity Catalysis of the removal of the methyl group from a modified arginine residue at position 3 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone demethylase activity (H4-R3 specific)|histone H3R3me demethylase activity https://github.com/geneontology/go-ontology/issues/21089 molecular_function owl:Class
GO:0032452 biolink:NamedThing histone demethylase activity Catalysis of the removal of a methyl group from a histone. got7fsn_ti Reactome:R-HSA-5661116|Reactome:R-HSA-5661114|Reactome:R-HSA-5661125|Reactome:R-HSA-5625797|Reactome:R-HSA-5661120|Reactome:R-HSA-5661115|Reactome:R-HSA-4722133|Reactome:R-HSA-3214912|Reactome:R-HSA-5661121|Reactome:R-HSA-5661124|Reactome:R-HSA-5661122|Reactome:R-HSA-4724279|Reactome:R-HSA-4754187|Reactome:R-HSA-4754181|Reactome:R-HSA-5625848|Reactome:R-HSA-4724284|Reactome:R-HSA-5625870|Reactome:R-HSA-5423117|Reactome:R-HSA-5661123|Reactome:R-HSA-4754176 molecular_function owl:Class
GO:0023059 biolink:NamedThing positive adaptation of signaling pathway The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. got7fsn_ti positive adaptation of signalling pathway 2010-02-16T09:30:50Z biological_process owl:Class
GO:0075039 biolink:NamedThing establishment of turgor in appressorium The process in which hydrostatic pressure is increased within the symbiont appressorium to breach the cuticle of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti generation of turgor in appressorium|formation of turgor in appressorium|establishment of turgor in symbiont appressorium on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0044111 biolink:NamedThing formation of structure involved in a symbiotic process The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction. got7fsn_ti development of symbiont during interaction with host|development involved in symbiotic interaction|development during symbiotic interaction|development on or near surface of other organism during symbiotic interaction|development of symbiont involved in interaction with host|development on or near surface of other organism involved in symbiotic interaction https://github.com/geneontology/go-ontology/issues/20305 jl 2009-07-30T02:26:46Z GO:0044152|GO:0044115 biological_process owl:Class
GO:0045776 biolink:NamedThing negative regulation of blood pressure Any process in which the force of blood traveling through the circulatory system is decreased. got7fsn_ti down regulation of blood pressure|downregulation of blood pressure|inhibition of blood pressure|down-regulation of blood pressure biological_process owl:Class
GO:0047800 biolink:NamedThing cysteamine dioxygenase activity Catalysis of the reaction: cysteamine + O(2) = H(+) + hypotaurine. got7fsn_ti cysteamine oxygenase activity|persulfurase activity|cysteamine:oxygen oxidoreductase activity|2-aminoethanethiol:oxygen oxidoreductase activity EC:1.13.11.19|RHEA:14409|Reactome:R-HSA-6814153|MetaCyc:CYSTEAMINE-DIOXYGENASE-RXN|KEGG_REACTION:R02467 molecular_function owl:Class
GO:0016461 biolink:NamedThing unconventional myosin complex A portmanteau term for myosins other than myosin II. got7fsn_ti non-muscle myosin Note that this term is retained because it is widely used by biologists. GO:0005860 cellular_component owl:Class
GO:0016459 biolink:NamedThing myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. got7fsn_ti cellular_component owl:Class
GO:0036265 biolink:NamedThing RNA (guanine-N7)-methylation The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule. got7fsn_ti bf 2012-06-25T10:28:25Z biological_process owl:Class
GO:0001510 biolink:NamedThing RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. got7fsn_ti biological_process owl:Class
GO:0070001 biolink:NamedThing aspartic-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. got7fsn_ti molecular_function owl:Class
GO:0008233 biolink:NamedThing peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. got7fsn_ti protease activity|peptidase activity, acting on L-amino acid peptides|peptidase activity, acting on D-amino acid peptides|proteinase activity|peptide hydrolase activity|hydrolase, acting on peptide bonds GO:0070010|GO:0070011 Reactome:R-HSA-5685902|EC:3.4.-.-|Reactome:R-HSA-5655483|Reactome:R-HSA-376149|Reactome:R-HSA-3065959|Reactome:R-HSA-3139027|Reactome:R-HSA-205112|Reactome:R-HSA-3065958|Reactome:R-HSA-6803060|Reactome:R-HSA-3000243|Reactome:R-HSA-4167501|Reactome:R-HSA-5693319|Reactome:R-HSA-448678|Reactome:R-HSA-5684864 molecular_function owl:Class
GO:0016059 biolink:NamedThing deactivation of rhodopsin mediated signaling The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon). got7fsn_ti rod response recovery|deactivation of rhodopsin mediated signalling biological_process owl:Class
GO:0022400 biolink:NamedThing regulation of rhodopsin mediated signaling pathway Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling. got7fsn_ti regulation of rhodopsin mediated signalling biological_process owl:Class
GO:0018554 biolink:NamedThing 1,2-dihydroxynaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached. got7fsn_ti UM-BBD_enzymeID:e0255|RHEA:27310|EC:1.13.11.56 molecular_function owl:Class
GO:0060805 biolink:NamedThing negative regulation of trophoblast cell differentiation by transcription regulation from RNA polymerase II promoter Any process that modulates the rate, frequency or extent of transcription from an RNA polymerase II promoter ultimately resulting in a decrease in trophoblast stem cells differentiating into the more mature cells of the trophoblast. got7fsn_ti dph 2009-08-06T01:58:25Z biological_process owl:Class
GO:0060806 biolink:NamedThing negative regulation of cell differentiation involved in embryonic placenta development Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state. got7fsn_ti dph 2009-08-06T02:02:18Z biological_process owl:Class
GO:0003916 biolink:NamedThing DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. got7fsn_ti GO:0009387 EC:5.6.2.- molecular_function owl:Class
GO:0047123 biolink:NamedThing quinoline-4-carboxylate 2-oxidoreductase activity Catalysis of the reaction: A + H(2)O + quinoline-4-carboxylate = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH(2). got7fsn_ti quinoline-4-carboxylic acid 2-oxidoreductase activity|quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating) KEGG_REACTION:R05183|RHEA:14949|EC:1.3.99.19|MetaCyc:1.3.99.19-RXN molecular_function owl:Class
GO:0016627 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on the CH-CH group of donors, other acceptors EC:1.3.-.-|Reactome:R-HSA-2995334|Reactome:R-HSA-9661710 molecular_function owl:Class
GO:0003859 biolink:NamedThing 3-hydroxybutyryl-CoA dehydratase activity Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O. got7fsn_ti enoyl coenzyme A hydrase (D)|crotonase activity|D-3-hydroxybutyryl-CoA dehydratase activity|(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity|(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)|D-3-hydroxybutyryl coenzyme A dehydratase activity RHEA:17849|KEGG_REACTION:R03027|MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN|EC:4.2.1.55 molecular_function owl:Class
GO:0018106 biolink:NamedThing peptidyl-histidine phosphorylation The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). got7fsn_ti RESID:AA0036|RESID:AA0035 biological_process owl:Class
GO:0018202 biolink:NamedThing peptidyl-histidine modification The modification of peptidyl-histidine. got7fsn_ti biological_process owl:Class
GO:0005610 biolink:NamedThing laminin-5 complex A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains. got7fsn_ti laminin-3A32 complex|laminin-332 complex|laminin-5A complex cellular_component owl:Class
GO:0023024 biolink:NamedThing MHC class I protein complex binding Binding to a class I major histocompatibility complex. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0023023 biolink:NamedThing MHC protein complex binding Binding to a major histocompatibility complex. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0055115 biolink:NamedThing entry into diapause The dormancy process that results in entry into diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. got7fsn_ti Wikipedia:Diapause biological_process owl:Class
GO:0008966 biolink:NamedThing phosphoglucosamine mutase activity Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. got7fsn_ti D-glucosamine 1,6-phosphomutase activity|alpha-D-glucosamine 1,6-phosphomutase activity MetaCyc:5.4.2.10-RXN|RHEA:23424|EC:5.4.2.10|KEGG_REACTION:R02060 molecular_function owl:Class
GO:0016868 biolink:NamedThing intramolecular transferase activity, phosphotransferases Catalysis of the transfer of a phosphate group from one position to another within a single molecule. got7fsn_ti phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers|phosphomutase activity GO:0016777 EC:5.4.2.- molecular_function owl:Class
GO:0102626 biolink:NamedThing parthenolide synthase activity Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> parthenolide + NADP(3-) + H2O. got7fsn_ti MetaCyc:RXN-15531 molecular_function owl:Class
GO:0010101 biolink:NamedThing post-embryonic root morphogenesis The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed. got7fsn_ti biological_process owl:Class
GO:0045766 biolink:NamedThing positive regulation of angiogenesis Any process that activates or increases angiogenesis. got7fsn_ti up-regulation of angiogenesis|activation of angiogenesis|stimulation of angiogenesis|up regulation of angiogenesis|upregulation of angiogenesis biological_process owl:Class
GO:1904018 biolink:NamedThing positive regulation of vasculature development Any process that activates or increases the frequency, rate or extent of vasculature development. got7fsn_ti up regulation of vasculature development|positive regulation of vascular system development|up-regulation of vascular system development|upregulation of vascular system development|up regulation of vascular system development|upregulation of vasculature development|activation of vascular system development|activation of vasculature development|up-regulation of vasculature development sl 2015-03-06T22:17:04Z biological_process owl:Class
GO:0039688 biolink:NamedThing viral double stranded DNA replication via reverse transcription A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. got7fsn_ti RNA-dependent viral DNA replication|dsDNA replication via RNA intermediate|viral RNA-dependent DNA replication bf 2013-10-17T15:00:08Z VZ:1938 biological_process owl:Class
GO:0039693 biolink:NamedThing viral DNA genome replication The replication of a viral DNA genome. got7fsn_ti DNA-dependent viral DNA replication|viral DNA-dependent DNA replication|viral DNA replication bf 2013-10-23T15:22:31Z GO:0039681 biological_process owl:Class
GO:0009900 biolink:NamedThing dehiscence The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it. got7fsn_ti Wikipedia:Dehiscence_(botany) biological_process owl:Class
GO:0022414 biolink:NamedThing reproductive process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. got7fsn_ti single organism reproductive process jl 2012-09-19T15:56:06Z GO:0044702 biological_process owl:Class
GO:0036503 biolink:NamedThing ERAD pathway The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. got7fsn_ti ER-associated degradation pathway|endoplasmic reticulum-associated protein degradation pathway|protein degradation by ERAD|endoplasmic reticulum-associated degradation ER-associated protein degradation (ERAD) pathways target misfolded ER lumenal proteins (ERAD-L), ER membrane proteins (ERAD-M), and ER proteins with misfolded cytosolic domains (ERAD-C) by recognizing aberrant proteins, retrotranslocating these substrates to the cytosol, followed by substrate ubiquitination and proteosomal-mediated degradation. In contrast the stress-induced homeostatically regulated protein degradation (SHRED) pathway (GO:0120174), although inducible by stress, targets diverse ER membrane, and cytosolic proteins as well as numerous other native proteins in the absence of stress. Stress results in the protease-mediated (Nma111p) generation of a Roq1p cleavage product that then binds to the type-1 active site of Ubr1p, altering its substrate specificity, and leading to the proteasome-mediated degradation of both misfolded and native proteins. Although the SHRED pathway may contain some components in common with ERAD pathways (GO:0036503), such as UBR1, RAD6 and CDC48, other ERAD components, such as HRD1 and DOA10, do not appear to be involved, and as such these pathways are currently considered to be distinct. bf 2015-05-14T11:43:06Z biological_process owl:Class
GO:0042812 biolink:NamedThing pheromone catabolic process The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. got7fsn_ti pheromone breakdown|pheromone degradation|pheromone catabolism GO:0007327|GO:0046614 biological_process owl:Class
GO:0042810 biolink:NamedThing pheromone metabolic process The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. got7fsn_ti pheromone metabolism biological_process owl:Class
GO:0072497 biolink:NamedThing mesenchymal stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti mah 2010-12-15T12:59:30Z biological_process owl:Class
GO:0048863 biolink:NamedThing stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. got7fsn_ti Wikipedia:Stem_cell_differentiation biological_process owl:Class
GO:0140658 biolink:NamedThing ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. got7fsn_ti nucleosome-dependent ATPase activity|ATP hydrolysis-dependent chromatin remodeler activity|nucleosome-activated ATPase activity|ATPase-dependent chromatin remodeler activity https://github.com/geneontology/go-ontology/issues/21786|https://github.com/geneontology/go-ontology/issues/6075|https://github.com/geneontology/go-ontology/issues/21609 pg 2021-06-15T13:57:18Z GO:0070615 molecular_function owl:Class
GO:0002426 biolink:NamedThing immunoglobulin production in mucosal tissue The synthesis and release of immunoglobulin in the mucosal tissue. got7fsn_ti antibody production in mucosal tissue Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0002381 biolink:NamedThing immunoglobulin production involved in immunoglobulin-mediated immune response The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti immunoglobulin production during immune response|immunoglobulin production involved in immune response|immunoglobulin biosynthetic process involved in immune response|immunoglobulin production involved in immunoglobulin mediated immune response|antibody secretion during immune response|immunoglobulin secretion involved in immune response|antibody production during immune response Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0002380|GO:0002379 biological_process owl:Class
GO:0047455 biolink:NamedThing 16-alpha-hydroxyprogesterone dehydratase activity Catalysis of the reaction: 16-alpha-hydroxyprogesterone = H2O + 16-dehydroprogesterone. got7fsn_ti 16-alpha-dehydroxylase activity|16alpha-dehydroxylase activity|16-alpha-hydroxyprogesterone dehydroxylase activity|16alpha-hydroxyprogesterone dehydratase activity|16alpha-hydroxyprogesterone dehydroxylase activity|hydroxyprogesterone dehydroxylase activity|16alpha-hydroxyprogesterone hydro-lyase activity|16alpha-hydroxyprogesterone hydro-lyase (16,17-didehydroprogesterone-forming)|16-dehydroprogesterone hydratase activity GO:0047523 RHEA:12584|EC:4.2.1.98|MetaCyc:4.2.1.98-RXN molecular_function owl:Class
GO:0034414 biolink:NamedThing tRNA 3'-trailer cleavage, endonucleolytic Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. got7fsn_ti tRNA 3'-end cleavage, endonucleolytic|endonucleolytic tRNA 3'-end cleavage|endonucleolytic tRNA 3'-trailer cleavage biological_process owl:Class
GO:0042779 biolink:NamedThing tRNA 3'-trailer cleavage Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. got7fsn_ti removal of tRNA 3'-trailer sequence|tRNA 3'-end cleavage biological_process owl:Class
GO:0008745 biolink:NamedThing N-acetylmuramoyl-L-alanine amidase activity Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides. got7fsn_ti acetylmuramoyl-alanine amidase activity|N-acylmuramyl-L-alanine amidase activity|N-acetylmuramylalanine amidase activity|N-acetylmuramoyl-L-alanine amidase type II|N-acetylmuramic acid L-alanine amidase activity|acetylmuramyl-alanine amidase activity|acetylmuramyl-L-alanine amidase activity|N-acetylmuramyl-L-alanine amidase activity|N-acetylmuramoyl-L-alanine amidase type I EC:3.5.1.28|MetaCyc:3.5.1.28-RXN|Reactome:R-HSA-6799977 molecular_function owl:Class
GO:0018629 biolink:NamedThing 2-hydroxyquinoline 5,6-dioxygenase activity Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+. got7fsn_ti 2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity|quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)|quinolin-2(1H)-one 5,6-dioxygenase activity|quinolin-2-ol 5,6-dioxygenase activity MetaCyc:1.14.12.16-RXN|UM-BBD_reactionID:r0052|EC:1.14.12.16|RHEA:10976 molecular_function owl:Class
GO:0051048 biolink:NamedThing negative regulation of secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. got7fsn_ti down-regulation of secretion|down regulation of secretion|downregulation of secretion|inhibition of secretion biological_process owl:Class
GO:0150053 biolink:NamedThing cerebellar climbing fiber to Purkinje cell synapse A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. got7fsn_ti cerebellar climbing fibre to Purkinje cell synapse bc 2018-05-09T09:57:20Z cellular_component owl:Class
GO:0098985 biolink:NamedThing asymmetric, glutamatergic, excitatory synapse A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials. got7fsn_ti cellular_component owl:Class
GO:0008126 biolink:NamedThing acetylesterase activity Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate. got7fsn_ti chloroesterase|acetic-ester acetylhydrolase activity|acetic ester hydrolase activity|p-nitrophenyl acetate esterase|C-esterase (in animal tissues)|citrus acetylesterase RHEA:12957|UM-BBD_reactionID:r0170|MetaCyc:ACETYLESTERASE-RXN|EC:3.1.1.6 molecular_function owl:Class
GO:0034338 biolink:NamedThing short-chain carboxylesterase activity Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. got7fsn_ti monobutyrase activity|butyrate esterase activity|propionyl esterase activity|short-chain esterase activity|methylbutyrase activity|methylbutyrate esterase activity|butyryl esterase activity molecular_function owl:Class
GO:0009238 biolink:NamedThing enterobactin metabolic process The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. got7fsn_ti enterochelin metabolic process|enterobactin metabolism|enterochelin metabolism biological_process owl:Class
GO:0009237 biolink:NamedThing siderophore metabolic process The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. got7fsn_ti siderochrome metabolic process|siderophore metabolism|siderochrome metabolism biological_process owl:Class
GO:0035087 biolink:NamedThing siRNA loading onto RISC involved in RNA interference The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference. got7fsn_ti RNA interference, siRNA loading onto RISC biological_process owl:Class
GO:0070922 biolink:NamedThing small RNA loading onto RISC The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of gene silencing by small RNA. got7fsn_ti RISC assembly|gene silencing by RNA, small RNA loading onto RISC mah 2009-09-11T03:57:38Z biological_process owl:Class
GO:0070919 biolink:NamedThing production of siRNA involved in gene silencing by small RNA Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of gene silencing by small RNA. got7fsn_ti production of siRNA involved in chromatin silencing by small RNA|chromatin silencing by small RNA, production of siRNA|chromatin silencing by small RNA, production of guide RNAs|production of guide RNAs involved in chromatin silencing by small RNA https://github.com/geneontology/go-ontology/issues/22058 mah 2009-09-11T03:39:18Z biological_process owl:Class
GO:0070918 biolink:NamedThing production of small RNA involved in gene silencing by RNA The process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease. got7fsn_ti gene silencing by RNA, production of small RNA|gene silencing by RNA, production of guide RNA mah 2009-09-11T03:32:19Z biological_process owl:Class
GO:0009340 biolink:NamedThing DNA topoisomerase IV complex A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA. got7fsn_ti cellular_component owl:Class
GO:0009330 biolink:NamedThing DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex Complex that possesses DNA topoisomerase II (double strand cut, ATP-hydrolyzing) activity. got7fsn_ti cellular_component owl:Class
GO:0072002 biolink:NamedThing Malpighian tubule development The process whose specific outcome is the progression of the Malpighian tubule over time, from its formation to the mature structure. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut. got7fsn_ti mah 2010-01-25T10:54:30Z biological_process owl:Class
GO:0002143 biolink:NamedThing tRNA wobble position uridine thiolation The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. got7fsn_ti tRNA wobble uridine thiolation|wobble position s2U biosynthesis In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA. hjd 2009-05-06T05:05:40Z biological_process owl:Class
GO:0002098 biolink:NamedThing tRNA wobble uridine modification The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified. got7fsn_ti biological_process owl:Class
GO:0034745 biolink:NamedThing APC-IQGAP1-Rac1 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Rac1, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0005892 biolink:NamedThing acetylcholine-gated channel complex A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. got7fsn_ti nicotinic acetylcholine-gated receptor-channel complex|nicotinic acetylcholine receptor cellular_component owl:Class
GO:0034702 biolink:NamedThing ion channel complex A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. got7fsn_ti cellular_component owl:Class
GO:1902492 biolink:NamedThing positive regulation of sperm capacitation Any process that activates or increases the frequency, rate or extent of sperm capacitation. got7fsn_ti positive regulation of sperm activation|upregulation of sperm capacitation|up-regulation of sperm activation|up regulation of sperm activation|activation of sperm capacitation|upregulation of sperm activation|activation of sperm activation|up regulation of sperm capacitation|up-regulation of sperm capacitation hjd 2013-11-12T21:17:21Z biological_process owl:Class
GO:1902490 biolink:NamedThing regulation of sperm capacitation Any process that modulates the frequency, rate or extent of sperm capacitation. got7fsn_ti regulation of sperm activation hjd 2013-11-12T21:17:03Z biological_process owl:Class
GO:0002191 biolink:NamedThing cap-dependent translational initiation The process where the cap structure, composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins, located at the 5' end of an mRNA molecule, which serves as a molecular tag that marks the spot where the 40S ribosomal subunit, is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation. got7fsn_ti hjd 2011-08-11T02:20:24Z biological_process owl:Class
GO:0002183 biolink:NamedThing cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. got7fsn_ti hjd 2011-06-09T03:15:48Z biological_process owl:Class
GO:0021787 biolink:NamedThing chemorepulsion of branchiomotor neuron axon in neural tube The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti negative chemotaxis of branchiomotor neuron axon in neural tube biological_process owl:Class
GO:0021786 biolink:NamedThing branchiomotor neuron axon guidance in neural tube The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti biological_process owl:Class
GO:0003330 biolink:NamedThing regulation of extracellular matrix constituent secretion Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. got7fsn_ti dph 2009-11-02T02:07:40Z biological_process owl:Class
GO:1903530 biolink:NamedThing regulation of secretion by cell Any process that modulates the frequency, rate or extent of secretion by cell. got7fsn_ti regulation of cellular secretion pm 2014-10-08T13:24:59Z biological_process owl:Class
GO:0048019 biolink:NamedThing receptor antagonist activity The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. got7fsn_ti receptor ligand activity molecular_function owl:Class
GO:0030547 biolink:NamedThing signaling receptor inhibitor activity Binds to and modulates the activity of a signaling receptor. got7fsn_ti receptor inhibitor activity molecular_function owl:Class
GO:0003828 biolink:NamedThing alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. got7fsn_ti ganglioside GD3 synthetase sialyltransferase activity|CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity|ganglioside GD3 synthase activity|CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity|alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity|GD3 synthase activity|CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity|alpha-2,8-sialyltransferase activity|SAT-2|cytidine monophosphoacetylneuraminate-ganglioside GM3 Reactome:R-HSA-1022133|Reactome:R-HSA-4084978|Reactome:R-HSA-422454|RHEA:19313|EC:2.4.99.8|MetaCyc:2.4.99.8-RXN molecular_function owl:Class
GO:0004962 biolink:NamedThing endothelin receptor activity Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti endothelin-A receptor activity|endothelin-B receptor activity GO:0001599|GO:0001600 molecular_function owl:Class
GO:0001139 biolink:NamedThing RNA polymerase II complex recruiting activity Binding to an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. got7fsn_ti core RNA polymerase II recruiting transcription factor activity|transcription factor activity, core RNA polymerase II recruiting krc 2011-01-20T05:55:01Z molecular_function owl:Class
GO:0000993 biolink:NamedThing RNA polymerase II complex binding Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. got7fsn_ti RNAP II core binding|RNA polymerase II core binding krc 2010-08-11T03:57:27Z molecular_function owl:Class
GO:0018421 biolink:NamedThing UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein. got7fsn_ti molecular_function owl:Class
GO:0004933 biolink:NamedThing mating-type a-factor pheromone receptor activity Combining with the mating-type a-factor pheromone to initiate a change in cell activity. got7fsn_ti class D G-protein coupled receptor activity|class D GPCR activity|class D G-protein-coupled receptor activity|class D G protein coupled receptor activity molecular_function owl:Class
GO:0004932 biolink:NamedThing mating-type factor pheromone receptor activity Combining with a mating-type factor pheromone to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0031152 biolink:NamedThing aggregation involved in sorocarp development The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. got7fsn_ti aggregate development involved in sorocarp development|aggregation during fruiting body development biological_process owl:Class
GO:0051703 biolink:NamedThing biological process involved in intraspecies interaction between organisms Any process in which an organism has an effect on an organism of the same species. got7fsn_ti intraspecies interaction between organisms|intraspecies interaction with other organisms https://github.com/geneontology/go-ontology/issues/20191 biological_process owl:Class
GO:0140035 biolink:NamedThing ubiquitination-like modification-dependent protein binding Binding to a protein upon modification by a ubiquitin-like protein of the target protein. got7fsn_ti This term should only be used when the binding is shown to require a ubiquitin-like modification in the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitin-like modification. It may be that the modification causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. pg 2017-05-18T06:11:27Z molecular_function owl:Class
GO:0140030 biolink:NamedThing modification-dependent protein binding Binding to a protein upon post-translation modification of the target protein. got7fsn_ti modified protein binding This term should only be used when the binding is shown to require a post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. pg 2017-05-17T11:50:41Z molecular_function owl:Class
GO:0110092 biolink:NamedThing nucleus leading edge The area of a motile nucleus closest to the direction of movement. got7fsn_ti horsetail nucleus leading edge kmv 2018-02-14T22:39:58Z cellular_component owl:Class
GO:2000848 biolink:NamedThing positive regulation of corticosteroid hormone secretion Any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion. got7fsn_ti positive regulation of corticosteroid secretion bf 2011-07-26T08:43:45Z biological_process owl:Class
GO:2000833 biolink:NamedThing positive regulation of steroid hormone secretion Any process that activates or increases the frequency, rate or extent of steroid hormone secretion. got7fsn_ti bf 2011-07-26T08:38:51Z biological_process owl:Class
GO:1990630 biolink:NamedThing IRE1-RACK1-PP2A complex A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A. got7fsn_ti ERN1-RACK1-PP2A complex|IRE1alpha-RACK1-PP2A complex bf 2015-02-05T15:37:58Z cellular_component owl:Class
GO:0001776 biolink:NamedThing leukocyte homeostasis The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti immune cell homeostasis|leucocyte homeostasis Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. biological_process owl:Class
GO:0048872 biolink:NamedThing homeostasis of number of cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells. got7fsn_ti homeostasis of cell number|cell population homeostasis biological_process owl:Class
GO:0048463 biolink:NamedThing carpel structural organization The process that contributes to the act of creating the structural organization of the carpel. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti carpel structural organisation GO:0048432 biological_process owl:Class
GO:0048450 biolink:NamedThing floral organ structural organization The process that contributes to the act of creating the structural organization of floral organs. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti floral organ structural organisation GO:0048435 biological_process owl:Class
GO:0060817 biolink:NamedThing inactivation of paternal X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes specifically on the paternal X-chromosome in the XX sex. got7fsn_ti dph 2009-08-11T10:50:20Z biological_process owl:Class
GO:0009048 biolink:NamedThing dosage compensation by inactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex. got7fsn_ti X chromosome inactivation|chromosome inactivation|Barr body formation Wikipedia:X-inactivation biological_process owl:Class
GO:0001193 biolink:NamedThing maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter. got7fsn_ti maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter krc 2011-09-02T02:31:00Z biological_process owl:Class
GO:0001192 biolink:NamedThing maintenance of transcriptional fidelity during DNA-templated transcription elongation Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template. got7fsn_ti maintenance of transcriptional fidelity during DNA-dependent transcription elongation krc 2011-09-02T02:25:30Z biological_process owl:Class
GO:0102196 biolink:NamedThing cortisol dehydrogenase activity Catalysis of the reaction: cortisol + NADP <=> cortisone + NADPH + H+. got7fsn_ti MetaCyc:RXN-12085 molecular_function owl:Class
GO:0000931 biolink:NamedThing gamma-tubulin large complex A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe. got7fsn_ti gamma-tubulin large complex, equatorial microtubule organizing centre|gamma-tubulin ring complex, centrosomal|gamma-tubulin large complex, eMTOC|gamma-tubulin large complex, equatorial microtubule organizing center|gamma-tubulin ring complex|gamma-tubulin large complex, centrosomal|gamma-tubulin large complex, spindle pole body|gamma-tubulin large complex, mitotic spindle pole body|gamma-tubulin large complex, interphase microtubule organizing center|gamma-tubulin large complex, interphase microtubule organizing centre|gamma-tubulin large complex, iMTOC https://github.com/geneontology/go-ontology/issues/20967 GO:0000929|GO:0055031|GO:0000925|GO:0000926|GO:0055032|GO:0055033|GO:0000924|GO:0061494|GO:0008274 cellular_component owl:Class
GO:0000930 biolink:NamedThing gamma-tubulin complex A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. got7fsn_ti cellular_component owl:Class
GO:0007509 biolink:NamedThing mesoderm migration involved in gastrulation The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism. got7fsn_ti biological_process owl:Class
GO:0090130 biolink:NamedThing tissue migration The process in which the population of cells that make up a tissue undergo directed movement. got7fsn_ti tb 2009-12-07T03:13:55Z biological_process owl:Class
GO:0050141 biolink:NamedThing nitroethane oxidase activity Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2. got7fsn_ti nitroethane reductase activity|nitroethane:oxygen oxidoreductase activity EC:1.7.3.1|MetaCyc:NITROETHANE-OXIDASE-RXN molecular_function owl:Class
GO:0052664 biolink:NamedThing nitroalkane oxidase activity Catalysis of the reaction: nitroalkane + H2O + O2 = an aldehyde or ketone + nitrite + H2O2. got7fsn_ti nitroalkane:oxygen oxidoreductase activity|nitroalkane reductase activity|NAO activity 2010-10-11T10:50:59Z EC:1.7.3.1|MetaCyc:RXN-11045|KEGG_REACTION:R00799 molecular_function owl:Class
GO:0014805 biolink:NamedThing smooth muscle adaptation Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. got7fsn_ti smooth muscle plasticity biological_process owl:Class
GO:0043500 biolink:NamedThing muscle adaptation A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. got7fsn_ti muscle plasticity biological_process owl:Class
GO:0032601 biolink:NamedThing connective tissue growth factor production The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Hcs24 production|Fisp12 production|CCN2 production|IGFBP8 production|hypertrophic chondrocyte-specific gene product 24 production|CTGF production biological_process owl:Class
GO:0018865 biolink:NamedThing acrylonitrile metabolic process The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. got7fsn_ti acrylonitrile metabolism UM-BBD_pathwayID:acr biological_process owl:Class
GO:0034641 biolink:NamedThing cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. got7fsn_ti cellular nitrogen compound metabolism biological_process owl:Class
GO:0003405 biolink:NamedThing optic vesicle elongation The developmental growth that results in the lengthening of the optic vesicle in the posterior direction. got7fsn_ti dph 2009-12-21T01:59:50Z biological_process owl:Class
GO:1900615 biolink:NamedThing emericellamide A metabolic process The chemical reactions and pathways involving emericellamide A. got7fsn_ti emericellamide A metabolism di 2012-05-15T07:59:59Z biological_process owl:Class
GO:0036236 biolink:NamedThing acyl glucuronidation The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside). got7fsn_ti bf 2012-05-18T04:26:25Z biological_process owl:Class
GO:0052695 biolink:NamedThing cellular glucuronidation The modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. got7fsn_ti cellular glucuronide biosynthetic process|cellular glucuronide biosynthesis|cellular glucuronoside biosynthesis|cellular glucuronoside biosynthetic process 2011-07-27T05:28:18Z biological_process owl:Class
GO:0004331 biolink:NamedThing fructose-2,6-bisphosphate 2-phosphatase activity Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. got7fsn_ti D-fructose-2,6-bisphosphate 2-phosphohydrolase activity|fructose-2,6-bisphosphatase activity|beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity GO:0004330 Reactome:R-HSA-70262|RHEA:17289|MetaCyc:3.1.3.46-RXN|Reactome:R-HSA-5628905|EC:3.1.3.46 molecular_function owl:Class
GO:0034364 biolink:NamedThing high-density lipoprotein particle A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. got7fsn_ti HDL particle|HDL2|HDL complex|HDL3|high-density lipoprotein class complex cellular_component owl:Class
GO:0070184 biolink:NamedThing mitochondrial tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA in a mitochondrion, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0070127 biolink:NamedThing tRNA aminoacylation for mitochondrial protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis in a mitochondrion. got7fsn_ti biological_process owl:Class
GO:0061696 biolink:NamedThing pituitary gonadotropin complex A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function. got7fsn_ti dph 2015-05-06T13:11:18Z cellular_component owl:Class
GO:0099106 biolink:NamedThing ion channel regulator activity Modulates the activity of a channel via direct interaction with it. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. got7fsn_ti molecular_function owl:Class
GO:0090504 biolink:NamedThing epiboly The expansion of one cell sheet over other cells or yolk. got7fsn_ti tb 2012-10-22T12:29:52Z biological_process owl:Class
GO:0002011 biolink:NamedThing morphogenesis of an epithelial sheet The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells. got7fsn_ti biological_process owl:Class
GO:0044345 biolink:NamedThing stromal-epithelial cell signaling involved in prostate gland development The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development. got7fsn_ti stromal-epithelial cell signalling involved in prostate gland development jl 2010-08-25T02:06:34Z biological_process owl:Class
GO:0007267 biolink:NamedThing cell-cell signaling Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions. got7fsn_ti cell-cell signalling biological_process owl:Class
GO:0061655 biolink:NamedThing Pup conjugating enzyme activity Isoenergetic transfer of Pup from one protein to another via the reaction X-Pup + Y -> Y-Pup + X, where both the X-Pup and Y-Pup linkages are thioester bonds between the C-terminal amino acid of Pup and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:30:46Z molecular_function owl:Class
GO:0072496 biolink:NamedThing Pup transferase activity Catalysis of the transfer of Pup from one protein to another via the reaction X-Pup + Y --> Y-Pup + X, where both X-Pup and Y-Pup are covalent linkages. got7fsn_ti Pup conjugating enzyme activity mah 2010-12-15T11:58:13Z molecular_function owl:Class
GO:0090278 biolink:NamedThing negative regulation of peptide hormone secretion Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. got7fsn_ti tb 2010-02-05T02:56:39Z biological_process owl:Class
GO:0052312 biolink:NamedThing modulation of transcription in other organism involved in symbiotic interaction Any process in which an organism modulates the frequency, rate or extent of transcription in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modulation of transcription in other organism during symbiotic interaction biological_process owl:Class
GO:0090462 biolink:NamedThing ornithine homeostasis Any process involved in the maintenance of an internal steady state of ornithine within an organism or cell. got7fsn_ti tb 2012-09-24T14:22:02Z biological_process owl:Class
GO:0080144 biolink:NamedThing amino acid homeostasis Any process involved in the maintenance of an internal steady state of amino acid within an organism or cell. got7fsn_ti dhl 2010-01-27T04:47:27Z biological_process owl:Class
GO:0018296 biolink:NamedThing protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine. got7fsn_ti RESID:AA0145 biological_process owl:Class
GO:0018293 biolink:NamedThing protein-FAD linkage The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD). got7fsn_ti biological_process owl:Class
GO:0102979 biolink:NamedThing homofuraneol oxidoreductase activity Catalysis of the reaction: homofuraneol + NADP <=> (2E)-2-ethylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+. got7fsn_ti RHEA:53944|MetaCyc:RXN-9564 molecular_function owl:Class
GO:0140226 biolink:NamedThing RNA topoisomerase activity Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA. got7fsn_ti pg 2018-05-29T11:06:37Z molecular_function owl:Class
GO:0016853 biolink:NamedThing isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. got7fsn_ti other isomerase activity Reactome:R-HSA-6787623|EC:5.-.-.- molecular_function owl:Class
GO:0030540 biolink:NamedThing female genitalia development The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure. got7fsn_ti female genital development biological_process owl:Class
GO:0048806 biolink:NamedThing genitalia development The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure. got7fsn_ti genital development biological_process owl:Class
GO:0007497 biolink:NamedThing posterior midgut development The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0021984 biolink:NamedThing adenohypophysis development The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. got7fsn_ti anterior pituitary development|adenophysis development|anterior pituitary gland development biological_process owl:Class
GO:0046856 biolink:NamedThing phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol. got7fsn_ti phosphatidylinositol phosphate dephosphorylation|PtdInsP catabolism|PtdInsP dephosphorylation|PIP catabolism|phosphoinositide dephosphorylation|phosphatidylinositol phosphate catabolic process GO:0046840 biological_process owl:Class
GO:0046839 biolink:NamedThing phospholipid dephosphorylation The process of removing one or more phosphate groups from a phosphorylated lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. got7fsn_ti biological_process owl:Class
GO:0038083 biolink:NamedThing peptidyl-tyrosine autophosphorylation The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein. got7fsn_ti receptor tyrosine kinase autophosphorylation|RTK autophosphorylation|tyrosine autophosphorylation bf 2012-02-01T02:14:18Z biological_process owl:Class
GO:0046777 biolink:NamedThing protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). got7fsn_ti protein amino acid autophosphorylation Wikipedia:Autophosphorylation biological_process owl:Class
GO:0001587 biolink:NamedThing Gq/11-coupled serotonin receptor activity Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. got7fsn_ti serotonin receptor activity, coupled via Gq/11|5-HT2 receptor activity molecular_function owl:Class
GO:0004993 biolink:NamedThing G protein-coupled serotonin receptor activity Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. got7fsn_ti G protein coupled serotonin receptor activity|5-HT receptor|G-protein coupled serotonin receptor activity|5-hydroxytryptamine receptor https://github.com/geneontology/go-ontology/issues/12942 GO:0001585|GO:0016609 Wikipedia:5-HT_receptor molecular_function owl:Class
GO:0048649 biolink:NamedThing caste determination, influence by genetic factors The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. got7fsn_ti biological_process owl:Class
GO:0048652 biolink:NamedThing polyphenic determination, influence by genetic factors The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to genetic cues. got7fsn_ti biological_process owl:Class
GO:0031783 biolink:NamedThing type 5 melanocortin receptor binding Binding to a type 5 melanocortin receptor. got7fsn_ti type 5 melanocortin receptor ligand molecular_function owl:Class
GO:0031779 biolink:NamedThing melanocortin receptor binding Binding to a melanocortin receptor. got7fsn_ti melanocortin receptor ligand molecular_function owl:Class
GO:0051213 biolink:NamedThing dioxygenase activity Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. got7fsn_ti Reactome:R-HSA-112121|Reactome:R-HSA-112125|Reactome:R-HSA-112124|Reactome:R-HSA-112120 molecular_function owl:Class
GO:0047407 biolink:NamedThing ADP-ribosyl-[dinitrogen reductase] hydrolase activity Catalysis of the reaction: ADP-ribosyl-[dinitrogen reductase] = adenosine diphosphate ribose + [dinitrogen reductase]. got7fsn_ti ADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity|ADP-ribosyl glycohydrolase activity|azoferredoxin-activating enzymes|ADP-ribosyl-dinitrogen reductase hydrolase activity|dinitrogenase reductase activating glycohydrolase activity|azoferredoxin glycosidase activity|dinitrogenase reductase-activating glycohydrolase activity MetaCyc:3.2.2.24-RXN|EC:3.2.2.24|RHEA:14493 molecular_function owl:Class
GO:0021964 biolink:NamedThing rubrospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord. got7fsn_ti biological_process owl:Class
GO:0021952 biolink:NamedThing central nervous system projection neuron axonogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. got7fsn_ti central nervous system axon tract development biological_process owl:Class
GO:0019165 biolink:NamedThing thiamine kinase activity Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate. got7fsn_ti ATP:thiamine phosphotransferase activity|thiamin phosphokinase activity|thiamin kinase (phosphorylating)|ATP:thiamin phosphotransferase activity|thiamin kinase activity RHEA:12012|KEGG_REACTION:R02134|EC:2.7.1.89|MetaCyc:THIKIN-RXN molecular_function owl:Class
GO:1904318 biolink:NamedThing regulation of smooth muscle contraction involved in micturition Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition. got7fsn_ti regulation of smooth muscle contraction involved in urination|regulation of urinary bladder smooth muscle contraction involved in micturition sl 2015-06-10T18:46:11Z biological_process owl:Class
GO:0044062 biolink:NamedThing regulation of excretion Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity. got7fsn_ti biological_process owl:Class
GO:0046155 biolink:NamedThing rhodopsin catabolic process The chemical reactions and pathways resulting in the breakdown of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. got7fsn_ti rhodopsin catabolism|rhodopsin degradation|rhodopsin breakdown biological_process owl:Class
GO:0046154 biolink:NamedThing rhodopsin metabolic process The chemical reactions and pathways involving rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas. got7fsn_ti rhodopsin metabolism biological_process owl:Class
GO:0102247 biolink:NamedThing malonyl-malonyl acyl carrier protein-condensing enzyme activity Catalysis of the reaction: 2 H+ + 2 a malonyl-[acp] <=> 2 carbon dioxide + an acetoacetyl-[acp] + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-12361 molecular_function owl:Class
GO:0003376 biolink:NamedThing sphingosine-1-phosphate receptor signaling pathway A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti S1P signaling pathway|sphingolipid signaling pathway|S1P receptor signaling pathway|sphingolipid signalling pathway|S1P-activated GPCR signaling pathway|S1P-stimulated signal transduction pathway|S1P-activated G-protein coupled receptor signaling pathway https://github.com/geneontology/go-ontology/issues/15822 dph 2009-12-09T06:30:12Z GO:0001789 biological_process owl:Class
GO:0007186 biolink:NamedThing G protein-coupled receptor signaling pathway A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane. got7fsn_ti GPCR signalling pathway|dimeric G-protein coupled receptor signalling pathway|G-protein-coupled receptor protein signalling pathway|G-protein coupled receptor signalling pathway|G-protein coupled receptor protein signal transduction|G protein coupled receptor protein signaling pathway|G-protein coupled receptor signaling pathway via GPCR dimer|GPCR signaling pathway|G protein coupled receptor protein signalling pathway|G-protein coupled receptor protein signaling pathway|dimeric G-protein coupled receptor signaling pathway GO:0038042 biological_process owl:Class
GO:0070705 biolink:NamedThing RNA nucleotide insertion The modification of an RNA molecule by insertion of one or more nucleotides. got7fsn_ti mah 2009-06-08T04:48:35Z biological_process owl:Class
GO:0009451 biolink:NamedThing RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. got7fsn_ti RNA editing The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. GO:0016547 Wikipedia:RNA_editing biological_process owl:Class
GO:0001698 biolink:NamedThing gastrin-induced gastric acid secretion The regulated release of gastric acid induced by the interaction of gastrin with its receptor. got7fsn_ti biological_process owl:Class
GO:0001696 biolink:NamedThing gastric acid secretion The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. got7fsn_ti hydrochloric acid secretion biological_process owl:Class
GO:0042749 biolink:NamedThing regulation of circadian sleep/wake cycle Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle. got7fsn_ti biological_process owl:Class
GO:0050795 biolink:NamedThing regulation of behavior Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. got7fsn_ti regulation of behaviour biological_process owl:Class
GO:0071013 biolink:NamedThing catalytic step 2 spliceosome A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. got7fsn_ti mammalian spliceosomal complex C1|yeast spliceosomal complex A2-2|mammalian spliceosomal complex C mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0004459 biolink:NamedThing L-lactate dehydrogenase activity Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. got7fsn_ti L-lactic acid dehydrogenase activity|L-lactic dehydrogenase activity Reactome:R-HSA-71849|Reactome:R-HSA-70510|EC:1.1.1.27|RHEA:23444|MetaCyc:L-LACTATE-DEHYDROGENASE-RXN|Reactome:R-HSA-6807826 molecular_function owl:Class
GO:0040040 biolink:NamedThing thermosensory behavior Behavior that is dependent upon the sensation of temperature. got7fsn_ti behavioral response to temperature stimulus|behavioural response to temperature stimulus|thermosensory behaviour biological_process owl:Class
GO:0009266 biolink:NamedThing response to temperature stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. got7fsn_ti response to thermal stimulus biological_process owl:Class
GO:0106139 biolink:NamedThing symbiont cell surface The cell surface of a secondary, endosymbiont organism with which the first organism is interacting. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti endosymbiont cell surface hjd 2018-08-15T18:56:57Z cellular_component owl:Class
GO:0044217 biolink:NamedThing other organism part Any constituent part of a secondary organism with which the first organism is interacting. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. jl 2009-11-12T01:18:21Z cellular_component owl:Class
GO:0018298 biolink:NamedThing protein-chromophore linkage The covalent or noncovalent attachment of a chromophore to a protein. got7fsn_ti biological_process owl:Class
GO:0090585 biolink:NamedThing protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0016971 biolink:NamedThing flavin-linked sulfhydryl oxidase activity Catalysis of the formation of disulfide bridges in proteins using FAD as the electron acceptor. got7fsn_ti molecular_function owl:Class
GO:0016972 biolink:NamedThing thiol oxidase activity Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O2. got7fsn_ti sulfhydryl oxidase activity|thiol:oxygen oxidoreductase activity RHEA:17357|MetaCyc:THIOL-OXIDASE-RXN|UM-BBD_reactionID:r1293|EC:1.8.3.2 molecular_function owl:Class
GO:0052889 biolink:NamedThing 9,9'-di-cis-zeta-carotene desaturation to 7,9,7',9'-tetra-cis-lycopene The series of reactions in which 9,9'-di-cis-zeta-carotene is desaturated to 7,9,9'-tri-cis-neurosporene, and then 7,9,7',9'-tetra-cis-lycopene. The overall reaction for this process is: 9,9'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7',9'-tetra-cis-lycopene. got7fsn_ti 9,9'-di-cis-zeta-carotene catabolism to 7,9,7',9'-tetra-cis-lycopene|7,9,7',9'-tetra-cis-lycopene biosynthesis from 9,9'-di-cis-zeta-carotene MetaCyc:RXN-12242|KEGG_REACTION:R07511 biological_process owl:Class
GO:0016119 biolink:NamedThing carotene metabolic process The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids. got7fsn_ti carotene metabolism biological_process owl:Class
GO:0031637 biolink:NamedThing regulation of neuronal synaptic plasticity in response to neurotrophin The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. got7fsn_ti neurotrophin-induced neuronal synaptic plasticity biological_process owl:Class
GO:0048168 biolink:NamedThing regulation of neuronal synaptic plasticity A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. got7fsn_ti Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:0050603 biolink:NamedThing thiophene-2-carbonyl-CoA monooxygenase activity Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+). got7fsn_ti thiophene-2-carboxyl-CoA dehydrogenase activity|thiophene-2-carboxyl-CoA monooxygenase activity|thiophene-2-carbonyl-CoA, hydrogen-donor:oxygen oxidoreductase activity|thiophene-2-carboxyl-CoA hydroxylase activity RHEA:18929|MetaCyc:1.14.99.35-RXN|UM-BBD_reactionID:r1235|EC:1.14.99.35|KEGG_REACTION:R05742 molecular_function owl:Class
GO:0052801 biolink:NamedThing bicyclic nitroimidazole metabolic process The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring. got7fsn_ti bicyclic nitroimidazole metabolism biological_process owl:Class
GO:0052802 biolink:NamedThing nitroimidazole metabolic process The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring. got7fsn_ti nitroimidazole metabolism biological_process owl:Class
GO:0097192 biolink:NamedThing extrinsic apoptotic signaling pathway in absence of ligand A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. got7fsn_ti extrinsic apoptosis in absence of ligand|dependence receptor signaling pathway|extrinsic apoptotic signalling pathway in absence of ligand For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154). pr 2011-11-23T09:37:09Z biological_process owl:Class
GO:0039580 biolink:NamedThing suppression by virus of host PKR signaling Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha, inhibiting protein synthesis as an antiviral response. got7fsn_ti suppression by virus of host EIF2AK2 activity|suppression by virus of host PKR activity https://github.com/geneontology/go-ontology/issues/21971 bf biological_process owl:Class
GO:0019057 biolink:NamedThing modulation by virus of host translation Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA. got7fsn_ti viral host shutoff protein|host cell shutoff|regulation of host mRNA translation by virus|modulation of host translation by virus|regulation of host translation by virus|viral perturbation of host cell mRNA translation|regulation of translation in host by virus|host cell protein synthesis shutoff|modification by virus of host cell mRNA translation biological_process owl:Class
GO:0045841 biolink:NamedThing negative regulation of mitotic metaphase/anaphase transition Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. got7fsn_ti inhibition of mitotic metaphase/anaphase transition|downregulation of mitotic metaphase/anaphase transition|down-regulation of mitotic metaphase/anaphase transition|down regulation of mitotic metaphase/anaphase transition biological_process owl:Class
GO:0045839 biolink:NamedThing negative regulation of mitotic nuclear division Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. got7fsn_ti inhibition of mitosis|negative regulation of mitosis|down regulation of mitosis|down-regulation of mitosis|downregulation of mitosis biological_process owl:Class
GO:0035011 biolink:NamedThing melanotic encapsulation of foreign target Formation of a multilayered, melanized sheath of cells around a foreign invader. got7fsn_ti biological_process owl:Class
GO:0035010 biolink:NamedThing encapsulation of foreign target Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization. got7fsn_ti biological_process owl:Class
GO:0061324 biolink:NamedThing canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation The canonical Wnt signaling pathway that contributes to the modulation of the expansion of a population of cardiac outflow tract cells. got7fsn_ti canonical Wnt receptor signalling pathway involved in positive regulation of cardiac outflow tract cell proliferation|canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation|canonical Wnt-activated signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation dph 2010-09-28T09:19:37Z biological_process owl:Class
GO:0061316 biolink:NamedThing canonical Wnt signaling pathway involved in heart development The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. got7fsn_ti canonical Wnt receptor signaling pathway involved in heart development|canonical Wnt receptor signalling pathway involved in heart development|canonical Wnt-activated signaling pathway involved in heart development dph 2010-09-24T09:25:03Z biological_process owl:Class
GO:0052131 biolink:NamedThing positive aerotaxis The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen. got7fsn_ti biological_process owl:Class
GO:0009454 biolink:NamedThing aerotaxis The directed movement of a motile cell or organism in response to environmental oxygen. got7fsn_ti taxis in response to atmospheric oxygen biological_process owl:Class
GO:0048307 biolink:NamedThing ferredoxin-nitrite reductase activity Catalysis of the reaction: NH3 + 2 H2O + 6 oxidized ferredoxin = nitrite + 6 reduced ferredoxin + 7 H+. got7fsn_ti ammonia:ferredoxin oxidoreductase activity MetaCyc:FERREDOXIN--NITRITE-REDUCTASE-RXN|EC:1.7.7.1|RHEA:18041 molecular_function owl:Class
GO:0098809 biolink:NamedThing nitrite reductase activity Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor. got7fsn_ti molecular_function owl:Class
GO:0002694 biolink:NamedThing regulation of leukocyte activation Any process that modulates the frequency, rate, or extent of leukocyte activation. got7fsn_ti regulation of leucocyte activation|regulation of immune cell activation biological_process owl:Class
GO:0035184 biolink:NamedThing histone threonine kinase activity Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. got7fsn_ti histone-threonine kinase activity molecular_function owl:Class
GO:0035173 biolink:NamedThing histone kinase activity Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. got7fsn_ti molecular_function owl:Class
GO:0120242 biolink:NamedThing 2-iminobutanoate deaminase activity Catalysis of the reaction: 2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+). got7fsn_ti 2-iminobutanoate/2-iminopropanoate deaminase https://github.com/geneontology/go-ontology/issues/19832 krc 2020-07-29T18:07:00Z KEGG_REACTION:R11098|MetaCyc:RXN-15123|RHEA:39975 molecular_function owl:Class
GO:0120241 biolink:NamedThing 2-iminobutanoate/2-iminopropanoate deaminase Catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. got7fsn_ti imine intermediate deaminase activity|2-iminopropanoate deaminase|2-iminobutanoate deaminase|enamine/imine deaminase https://github.com/geneontology/go-ontology/issues/19832 This enzyme, which has been found in all species and tissues examined, catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates (from EC:3.5.99.10). krc 2020-07-29T17:28:19Z EC:3.5.99.10 molecular_function owl:Class
GO:0016159 biolink:NamedThing muconolactone delta-isomerase activity Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate. got7fsn_ti muconolactone isomerase activity|5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity|muconolactone D-isomerase activity RHEA:12348|MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN|EC:5.3.3.4 molecular_function owl:Class
GO:0016863 biolink:NamedThing intramolecular oxidoreductase activity, transposing C=C bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. got7fsn_ti intramolecular isomerase activity, transposing C=C bonds EC:5.3.3.- molecular_function owl:Class
GO:0017024 biolink:NamedThing myosin I binding Binding to a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments. got7fsn_ti molecular_function owl:Class
GO:0017022 biolink:NamedThing myosin binding Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. got7fsn_ti myosin phosphatase myosin binding molecular_function owl:Class
GO:0047200 biolink:NamedThing tetrahydrodipicolinate N-acetyltransferase activity Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + acetyl-CoA + H(2)O = L-2-acetamido-6-oxopimelate + CoA. got7fsn_ti tetrahydrodipicolinate:acetyl-CoA acetyltransferase activity|acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase activity|tetrahydrodipicolinate acetylase activity|acetyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate 2-N-acetyltransferase activity|acetyl-CoA:(S)-2,3,4,5-tetrahydrodipicolinate-2,6-dicarboxylate N2-acetyltransferase activity RHEA:13085|MetaCyc:2.3.1.89-RXN|KEGG_REACTION:R04364|EC:2.3.1.89 molecular_function owl:Class
GO:0031509 biolink:NamedThing subtelomeric heterochromatin assembly The assembly of chromatin into heterochromatin at the subtelomeric region, resulting in a chromatin conformation refractory to transcription. got7fsn_ti Telomere Position Effect|telomeric heterochromatin assembly|chromatin silencing at subtelomere|heterochromatic silencing at subtelomere|regulation of chromatin silencing at telomere|establishment of chromatin silencing at telomere|telomere chromatin silencing|telomeric heterochromatin formation|chromatin silencing at telomere|telomeric silencing|subtelomere chromatin silencing|subtelomeric silencing|regulation of subtelomeric heterochromatin assembly|heterochromatic silencing at telomere https://github.com/geneontology/go-ontology/issues/22027|https://github.com/geneontology/go-ontology/issues/19308|https://github.com/geneontology/go-ontology/issues/19188 GO:0099114|GO:0006348|GO:0035390 biological_process owl:Class
GO:0042653 biolink:NamedThing mitochondrial respiratory chain complex I, membrane segment The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. got7fsn_ti NADH-Q oxidoreductase complex, membrane segment cellular_component owl:Class
GO:0098798 biolink:NamedThing mitochondrial protein-containing complex A protein complex that is part of a mitochondrion. got7fsn_ti mitochondrial protein complex Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class
GO:0050385 biolink:NamedThing ureidoglycolate lyase activity Catalysis of the reaction: (S)-ureidoglycolate = glyoxylate + urea. got7fsn_ti ureidoglycolate hydrolase activity|ureidoglycolatase activity|(S)-ureidoglycolate urea-lyase activity|(S)-ureidoglycolate urea-lyase (glyoxylate-forming)|ureidoglycolase activity Take care to annotate to the reaction, not simply by enzyme name. Note that the name "ureidoglycolate hydrolase" (listed as a synonym here) has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19 ; GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3 ; GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. MetaCyc:UREIDOGLYCOLATE-LYASE-RXN|KEGG_REACTION:R00776|EC:4.3.2.3|RHEA:11304 molecular_function owl:Class
GO:0016842 biolink:NamedThing amidine-lyase activity Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. got7fsn_ti EC:4.3.2.- molecular_function owl:Class
GO:0009690 biolink:NamedThing cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. got7fsn_ti cytokinin metabolism biological_process owl:Class
GO:0006725 biolink:NamedThing cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. got7fsn_ti aromatic compound metabolism|aromatic hydrocarbon metabolic process|aromatic hydrocarbon metabolism biological_process owl:Class
GO:0080082 biolink:NamedThing esculin beta-glucosidase activity Catalysis of the hydrolysis of glucosidic link in esculin. got7fsn_ti dhl 2009-04-14T04:09:42Z molecular_function owl:Class
GO:0008422 biolink:NamedThing beta-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. got7fsn_ti primeverosidase activity|arbutinase activity|salicilinase activity|gentobiase activity|elaterase activity|beta-glucoside glucohydrolase activity|limarase activity|gentiobiase activity|aryl-beta-glucosidase activity|beta-D-glucosidase activity|cytokine beta-glucosidase activity|beta-D-glucoside glucohydrolase activity|emulsin|beta-1,6-glucosidase activity|cellobiase activity|amygdalase activity|amygdalinase|p-nitrophenyl beta-glucosidase activity GO:0016983 MetaCyc:3.2.1.21-RXN|EC:3.2.1.21 molecular_function owl:Class
GO:0004527 biolink:NamedThing exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. got7fsn_ti exonuclease IX activity GO:0008857 molecular_function owl:Class
GO:0004518 biolink:NamedThing nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids. got7fsn_ti Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. molecular_function owl:Class
GO:0018553 biolink:NamedThing 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate. got7fsn_ti UM-BBD_enzymeID:e0309 molecular_function owl:Class
GO:0071454 biolink:NamedThing cellular response to anoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. got7fsn_ti cellular response to anoxic stress|cellular response to anaerobic conditions Note that this term should not be confused with 'cellular response to hypoxia ; GO:0071456'. mah 2009-12-16T04:44:20Z biological_process owl:Class
GO:0080114 biolink:NamedThing positive regulation of glycine hydroxymethyltransferase activity Any process that activates or increases the frequency, rate or extent of glycine hydroxymethyltransferase activity, the catalysis of the reaction 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. got7fsn_ti dhl 2009-04-27T03:27:15Z biological_process owl:Class
GO:0006895 biolink:NamedThing Golgi to endosome transport The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes. got7fsn_ti TGN to endosome transport|Golgi to endosome vesicle-mediated transport|trans-Golgi to endosome transport GO:0048218 biological_process owl:Class
GO:0009604 biolink:NamedThing detection of symbiotic bacterium The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal. got7fsn_ti perception of symbiotic bacteria|detection of symbiotic bacteria|perception of symbiotic bacterium biological_process owl:Class
GO:0009602 biolink:NamedThing detection of symbiont The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti perception of symbiont|recognition of symbiont https://github.com/geneontology/go-ontology/issues/17977 GO:0051855 biological_process owl:Class
GO:0061626 biolink:NamedThing pharyngeal arch artery morphogenesis The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery. got7fsn_ti aortic arch artery morphogenesis dph 2014-05-09T15:34:06Z biological_process owl:Class
GO:0048844 biolink:NamedThing artery morphogenesis The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. got7fsn_ti arteriogenesis|arterial morphogenesis biological_process owl:Class
GO:0018756 biolink:NamedThing ammeline aminohydrolase activity Catalysis of the reaction: ammeline + H2O = ammelide + NH3. got7fsn_ti MetaCyc:RXN-8016|RHEA:26201 molecular_function owl:Class
GO:0016813 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. got7fsn_ti EC:3.5.3.- molecular_function owl:Class
GO:0035224 biolink:NamedThing genital disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium). got7fsn_ti biological_process owl:Class
GO:0007448 biolink:NamedThing anterior/posterior pattern specification, imaginal disc The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form. got7fsn_ti biological_process owl:Class
GO:0047103 biolink:NamedThing 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity Catalysis of the reaction: H2O + NAD+ + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al = NADH + 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate. got7fsn_ti 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase activity|3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-dehydrogenase activity|THAL-NAD oxidoreductase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al dehydrogenase activity|cholestanetriol-26-al 26-dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-dehydrogenase activity|trihydroxydeoxycoprostanal dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase activity MetaCyc:1.2.1.40-RXN|RHEA:24584 molecular_function owl:Class
GO:0002167 biolink:NamedThing VRK3/VHR/ERK complex A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway. got7fsn_ti hjd 2010-03-04T01:15:05Z cellular_component owl:Class
GO:0021626 biolink:NamedThing central nervous system maturation A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. got7fsn_ti biological_process owl:Class
GO:0060830 biolink:NamedThing ciliary receptor clustering involved in smoothened signaling pathway Grouping of smoothened or patched receptors in a cilium, contributing to the smoothened signaling pathway. got7fsn_ti ciliary receptor clustering involved in hedgehog signaling pathway|ciliary receptor clustering involved in smoothened signalling pathway|ciliary receptor clustering involved in hh signaling pathway dph 2009-08-11T02:06:33Z biological_process owl:Class
GO:0043113 biolink:NamedThing receptor clustering The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. got7fsn_ti biological_process owl:Class
GO:0005581 biolink:NamedThing collagen trimer A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. got7fsn_ti Wikipedia:Collagen cellular_component owl:Class
GO:0002702 biolink:NamedThing positive regulation of production of molecular mediator of immune response Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response. got7fsn_ti upregulation of production of molecular mediator of immune response|up regulation of production of molecular mediator of immune response|stimulation of production of molecular mediator of immune response|up-regulation of production of molecular mediator of immune response|activation of production of molecular mediator of immune response biological_process owl:Class
GO:0002700 biolink:NamedThing regulation of production of molecular mediator of immune response Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response. got7fsn_ti biological_process owl:Class
GO:0060242 biolink:NamedThing contact inhibition The series of events in which information about the density of cells in a population is received by direct cell-cell contact and is converted into a molecular signal, resulting in the cessation of cell growth or proliferation. got7fsn_ti detection of cell density by contact stimulus involved in contact inhibition|detection of cell density by contact stimulus GO:0060248|GO:0060246 Wikipedia:Contact_inhibition biological_process owl:Class
GO:0060245 biolink:NamedThing detection of cell density The series of events in which information about the density of cells in a population is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0046940 biolink:NamedThing nucleoside monophosphate phosphorylation The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside. got7fsn_ti biological_process owl:Class
GO:0009123 biolink:NamedThing nucleoside monophosphate metabolic process The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar. got7fsn_ti nucleoside monophosphate metabolism biological_process owl:Class
GO:0000411 biolink:NamedThing positive regulation of transcription by galactose Any process involving galactose that activates or increases the rate of transcription. got7fsn_ti up regulation of transcription by galactose|stimulation of transcription by galactose|activation of transcription by galactose|up-regulation of transcription by galactose|upregulation of transcription by galactose biological_process owl:Class
GO:0010327 biolink:NamedThing acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate. got7fsn_ti hexenol acetyltransferase molecular_function owl:Class
GO:0005550 biolink:NamedThing pheromone binding Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. got7fsn_ti molecular_function owl:Class
GO:0005549 biolink:NamedThing odorant binding Binding to an odorant, any substance capable of stimulating the sense of smell. got7fsn_ti molecular_function owl:Class
GO:0009455 biolink:NamedThing redox taxis The directed movement of a motile cell or organism in response to redox potential. got7fsn_ti redoxtaxis|taxis in response to redox potential|taxis in response to redox stimulus biological_process owl:Class
GO:0051775 biolink:NamedThing response to redox state Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. got7fsn_ti redox signal response GO:0006980 biological_process owl:Class
GO:0044176 biolink:NamedThing host cell filopodium Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. got7fsn_ti host filopodium jl 2009-09-04T03:06:59Z cellular_component owl:Class
GO:0044157 biolink:NamedThing host cell projection A prolongation or process extending from a host cell, e.g. a flagellum or axon. got7fsn_ti jl 2009-08-11T04:07:24Z cellular_component owl:Class
GO:0016714 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti EC:1.14.16.- molecular_function owl:Class
GO:0034996 biolink:NamedThing RasGAP-Fyn-Lyn-Yes complex A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation. got7fsn_ti p21(ras)GAP-Fyn-Lyn-Yes complex, thrombin stimulated Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0039503 biolink:NamedThing suppression by virus of host innate immune response Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense. got7fsn_ti negative regulation by virus of host innate immune response|inhibition of host innate immune response by virus|negative regulation by virus of host innate immunity|suppression by virus of host innate immunity bf 2011-05-11T04:31:17Z biological_process owl:Class
GO:0102050 biolink:NamedThing indole-3-acetyl-tyrosine synthetase activity Catalysis of the reaction: indole-3-acetate + L-tyrosine + ATP(4-) <=> H+ + indole-3-acetyl-tyrosine + AMP(2-) + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10432 molecular_function owl:Class
GO:0016879 biolink:NamedThing ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti other carbon-nitrogen ligase activity EC:6.3.-.- molecular_function owl:Class
GO:0050029 biolink:NamedThing L-lysine oxidase activity Catalysis of the reaction: L-lysine + H(2)O + O(2) = 6-amino-2-oxohexanoate + H(2)O(2) + NH(4)(+). got7fsn_ti L-lysyl-alpha-oxidase activity|L-lysine:oxygen 2-oxidoreductase (deaminating)|L-lysine alpha-oxidase activity EC:1.4.3.14|MetaCyc:PWY-5311|KEGG_REACTION:R00447|MetaCyc:L-LYSINE-OXIDASE-RXN|RHEA:14437 molecular_function owl:Class
GO:0001716 biolink:NamedThing L-amino-acid oxidase activity Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. got7fsn_ti L-amino-acid:oxygen oxidoreductase (deaminating)|ophio-amino-acid oxidase activity RHEA:13781|MetaCyc:L-AMINO-ACID-OXIDASE-RXN|Reactome:R-HSA-2160492|EC:1.4.3.2 molecular_function owl:Class
GO:0047860 biolink:NamedThing diiodophenylpyruvate reductase activity Catalysis of the reaction: 3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + H(+) + NADH. got7fsn_ti 3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase activity|KAR|aromatic alpha-keto acid|2-oxo acid reductase activity KEGG_REACTION:R03431|RHEA:20293|MetaCyc:DIIODOPHENYLPYRUVATE-REDUCTASE-RXN|EC:1.1.1.96 molecular_function owl:Class
GO:0061154 biolink:NamedThing endothelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. got7fsn_ti dph 2010-06-15T09:05:00Z biological_process owl:Class
GO:0003159 biolink:NamedThing morphogenesis of an endothelium The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. got7fsn_ti dph 2009-10-01T01:34:06Z biological_process owl:Class
GO:0044855 biolink:NamedThing plasma membrane raft distribution The process that establishes the spatial arrangement of membrane rafts within a plasma membrane. got7fsn_ti jl 2014-07-23T16:00:41Z biological_process owl:Class
GO:0044856 biolink:NamedThing plasma membrane raft localization Any process in which plasma membrane rafts are transported to, or maintained in, a specific location. got7fsn_ti jl 2014-07-23T16:12:22Z biological_process owl:Class
GO:0034376 biolink:NamedThing conversion of discoidal high-density lipoprotein particle to spherical high-density lipoprotein particle The process in which a discoidal high-density lipoprotein (HDL) particle acquires additional lipid or protein molecules, and cholesterol in the particle is converted to tightly bound cholesterol esters by the action of phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT), resulting in the formation of a spherical HDL particle. got7fsn_ti discoidal high-density lipoprotein remodeling|discoidal HDL remodeling|conversion of discoidal HDL to spherical HDL biological_process owl:Class
GO:0034375 biolink:NamedThing high-density lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a high-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL. got7fsn_ti HDL remodeling biological_process owl:Class
GO:0010842 biolink:NamedThing retina layer formation The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia. got7fsn_ti retinal layer formation|retinal lamination biological_process owl:Class
GO:0052795 biolink:NamedThing exo-alpha-(2->6)-sialidase activity Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates. got7fsn_ti exo-alpha-2,6-sialidase activity|exo-alpha-(2,6)-sialidase activity EC:3.2.1.18 molecular_function owl:Class
GO:0004308 biolink:NamedThing exo-alpha-sialidase activity Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. got7fsn_ti alpha-neuraminidase activity|acetylneuraminyl hydrolase activity|acetylneuraminidase activity|N-acylneuraminate glycohydrolase activity|neuraminidase activity|sialidase activity Reactome:R-HSA-4085029|Reactome:R-HSA-1605724|Reactome:R-HSA-4084994|Reactome:R-HSA-168870|EC:3.2.1.18|Reactome:R-HSA-4341669|Reactome:R-HSA-1605768|Reactome:R-HSA-1605723|Reactome:R-HSA-9638120|MetaCyc:3.2.1.18-RXN|Reactome:R-HSA-4084999 molecular_function owl:Class
GO:1990665 biolink:NamedThing AnxA2-p11 complex A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10). got7fsn_ti (p11)2.(AnxA2)2 complex|AnxA2.p11 complex|AnxA2:S100A10 heterotetramer|Annexin A2 tetramer|Annexin A2-p11 complex|(A2.p11)2 complex bf 2015-03-02T10:07:42Z cellular_component owl:Class
GO:0009972 biolink:NamedThing cytidine deamination The removal of amino group in the presence of water. got7fsn_ti biological_process owl:Class
GO:0006216 biolink:NamedThing cytidine catabolic process The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside. got7fsn_ti cytidine degradation|cytidine catabolism|cytidine breakdown biological_process owl:Class
GO:0045055 biolink:NamedThing regulated exocytosis A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. got7fsn_ti regulated secretory pathway biological_process owl:Class
GO:0006887 biolink:NamedThing exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. got7fsn_ti nonselective vesicle exocytosis|vesicle exocytosis GO:0016194|GO:0016195 Wikipedia:Exocytosis biological_process owl:Class
GO:0051507 biolink:NamedThing beta-sitosterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol. got7fsn_ti RHEA:61832|MetaCyc:RXN-12128 molecular_function owl:Class
GO:0016906 biolink:NamedThing sterol 3-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol. got7fsn_ti sterol:UDPG glucosyltransferase activity|sterol 3beta-glucosyltransferase activity|UDPG:sterol glucosyltransferase activity|sterol-beta-D-glucosyltransferase activity|UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity|UDP-glucose:sterol glucosyltransferase activity|UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity|UDP-glucose-sterol beta-glucosyltransferase activity|UDPG-SGTase activity|sterol glucosyltransferase activity|uridine diphosphoglucose-poriferasterol glucosyltransferase activity|UDP-glucose-sterol glucosyltransferase activity|uridine diphosphoglucose-sterol glucosyltransferase activity EC:2.4.1.173|MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN|RHEA:22724 molecular_function owl:Class
GO:0000971 biolink:NamedThing tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans. got7fsn_ti krc 2009-04-28T10:36:17Z biological_process owl:Class
GO:0000968 biolink:NamedThing tRNA exon ligation An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed. got7fsn_ti krc 2009-04-28T10:22:40Z biological_process owl:Class
GO:0097580 biolink:NamedThing intracellular sequestering of copper ion The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system. got7fsn_ti intracellular retention of copper ion|intracellular storage of copper ion|intracellular copper ion sequestering|intracellular copper ion storage|intracellular sequestration of copper ion|intracellular copper ion retention|intracellular copper ion sequestration pr 2014-02-28T11:21:39Z biological_process owl:Class
GO:0051651 biolink:NamedThing maintenance of location in cell Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. got7fsn_ti retention within cell|sequestering within cell|cellular retention|storage within cell|cellular storage|intracellular retention|maintenance of intracellular localization|maintenance of localization in cell|maintenance of localization within cell|cellular sequestering|intracellular sequestering|maintenance of cellular localization|intracellular storage biological_process owl:Class
GO:0046878 biolink:NamedThing positive regulation of saliva secretion Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. got7fsn_ti up-regulation of saliva secretion|activation of saliva secretion|stimulation of saliva secretion|up regulation of saliva secretion|upregulation of saliva secretion biological_process owl:Class
GO:0060456 biolink:NamedThing positive regulation of digestive system process Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class
GO:0016295 biolink:NamedThing myristoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate. got7fsn_ti myristoyl-ACP hydrolase activity|tetradecanoyl-ACP hydrolase activity|myristoyl-[acyl-carrier protein] hydrolase activity|tetradecanoyl-[acyl-carrier-protein] hydrolase activity RHEA:30123|EC:3.1.2.14|MetaCyc:RXN-10727|KEGG_REACTION:R08159 molecular_function owl:Class
GO:0016297 biolink:NamedThing acyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid. got7fsn_ti acyl-ACP-hydrolase activity|acyl-acyl carrier protein hydrolase activity|acyl-ACP thioesterase activity|acyl-[acyl-carrier protein] hydrolase activity|acyl-ACP hydrolase activity|acyl-acyl-carrier-protein hydrolase activity|S-acyl fatty acid synthase thioesterase activity GO:0010281 Reactome:R-HSA-5655955|EC:3.1.2.14|RHEA:30131|MetaCyc:RXN-7902 molecular_function owl:Class
GO:0090194 biolink:NamedThing negative regulation of glomerulus development Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. got7fsn_ti tb 2009-12-18T11:17:13Z biological_process owl:Class
GO:0090185 biolink:NamedThing negative regulation of kidney development Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti negative regulation of nephrogenesis tb 2009-12-18T10:58:45Z biological_process owl:Class
GO:0016275 biolink:NamedThing [cytochrome c]-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine. got7fsn_ti cytochrome c-arginine N-methyltransferase activity|S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea|S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea RHEA:21872|EC:2.1.1.124|MetaCyc:2.1.1.124-RXN molecular_function owl:Class
GO:0016274 biolink:NamedThing protein-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. got7fsn_ti PRMT activity Reactome:R-HSA-5229203|Reactome:R-HSA-5205798|Reactome:R-HSA-8879123|Reactome:R-HSA-191790|Reactome:R-HSA-5205820|Reactome:R-HSA-5205824|Reactome:R-HSA-5205822|Reactome:R-HSA-5229010|Reactome:R-HSA-5218952|Reactome:R-HSA-8934735|Reactome:R-HSA-5661126|Reactome:R-HSA-5205867 molecular_function owl:Class
GO:1990711 biolink:NamedThing beta-catenin-ICAT complex Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex. got7fsn_ti Beta-catenin-ICAT complex|CTNNB1-CTNNBIP1 complex An example of this is Catenin beta-1 in human (UniProt symbol P35222) in PMID:12408824 (inferred from physical interaction). bhm 2015-03-25T21:08:11Z cellular_component owl:Class
GO:0090571 biolink:NamedThing RNA polymerase II transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter. got7fsn_ti tb 2014-05-09T13:26:16Z cellular_component owl:Class
GO:0070275 biolink:NamedThing aerobic ammonia oxidation to nitrite via pyruvic oxime The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen. Hydroxylamine is produced enzymatically, and, in the presence of pyruvate, forms pyruvic oxime in a spontaneous, non-enzymatic reaction; pyruvic oxime is then converted to nitrite. got7fsn_ti MetaCyc:PWY-2242 biological_process owl:Class
GO:0019329 biolink:NamedThing ammonia oxidation The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons. got7fsn_ti biological_process owl:Class
GO:1990751 biolink:NamedThing Schwann cell chemotaxis The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti sl 2015-05-21T19:19:09Z biological_process owl:Class
GO:0036135 biolink:NamedThing Schwann cell migration The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function. got7fsn_ti bf 2012-03-06T10:44:39Z biological_process owl:Class
GO:0033043 biolink:NamedThing regulation of organelle organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. got7fsn_ti regulation of organelle organisation|regulation of organelle organization and biogenesis biological_process owl:Class
GO:0051128 biolink:NamedThing regulation of cellular component organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. got7fsn_ti regulation of cellular component organisation|regulation of cell organization|regulation of cellular component organization and biogenesis|regulation of cell organisation biological_process owl:Class
GO:0031128 biolink:NamedThing developmental induction A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder). got7fsn_ti biological_process owl:Class
GO:0042925 biolink:NamedThing benzoate transmembrane transporter activity Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) from one side of a membrane to the other. got7fsn_ti benzoate transporter activity RHEA:32811 molecular_function owl:Class
GO:0052877 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor. got7fsn_ti EC:1.4.9.- molecular_function owl:Class
GO:0060508 biolink:NamedThing lung basal cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature basal cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. A basal cell is an epithelial stem cell. got7fsn_ti pulmonary basal cell differentiation biological_process owl:Class
GO:0060479 biolink:NamedThing lung cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti pulmonary cell differentiation biological_process owl:Class
GO:0003949 biolink:NamedThing 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. got7fsn_ti 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity|N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity|N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity|1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity|phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity|phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity EC:5.3.1.16|RHEA:15469|KEGG_REACTION:R04640|MetaCyc:PRIBFAICARPISOM-RXN molecular_function owl:Class
GO:0033473 biolink:NamedThing indoleacetic acid conjugate metabolic process The chemical reactions and pathways involving any indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule. got7fsn_ti IAA conjugate metabolic process|indole acetic acid conjugate metabolic process|indole acetic acid conjugate metabolism|indoleacetic acid conjugate metabolism biological_process owl:Class
GO:0009683 biolink:NamedThing indoleacetic acid metabolic process The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants. got7fsn_ti indole acetic acid metabolism|IAA metabolic process|indoleacetic acid metabolism|indole acetic acid metabolic process biological_process owl:Class
GO:0071736 biolink:NamedThing IgG immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgG2a antibody|IgG2b antibody|IgG4 antibody|IgG3 antibody|IgG2 antibody|IgG antibody|IgG1 antibody|IgG2c antibody Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0006336 biolink:NamedThing DNA replication-independent nucleosome assembly The formation of nucleosomes outside the context of DNA replication. got7fsn_ti transcription-coupled nucleosome assembly biological_process owl:Class
GO:0034724 biolink:NamedThing DNA replication-independent nucleosome organization The formation or destruction of chromatin structures, occurring outside the context of DNA replication. got7fsn_ti DNA replication-independent nucleosome organisation biological_process owl:Class
GO:0009039 biolink:NamedThing urease activity Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. got7fsn_ti urea amidohydrolase activity MetaCyc:UREASE-RXN|UM-BBD_reactionID:r0120|RHEA:20557|EC:3.5.1.5 molecular_function owl:Class
GO:0010214 biolink:NamedThing seed coat development The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0034645 biolink:NamedThing cellular macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. got7fsn_ti cellular macromolecule biosynthesis|cellular macromolecule formation|cellular macromolecule anabolism|cellular biopolymer biosynthetic process|cellular macromolecule synthesis GO:0034961 biological_process owl:Class
GO:0009059 biolink:NamedThing macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biopolymer biosynthetic process|macromolecule biosynthesis|macromolecule synthesis|macromolecule anabolism|macromolecule formation GO:0043284 biological_process owl:Class
GO:0008719 biolink:NamedThing dihydroneopterin triphosphate 2'-epimerase activity Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate. got7fsn_ti D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity EC:5.1.99.7|MetaCyc:H2NTPEPIM-RXN|RHEA:28346 molecular_function owl:Class
GO:0090724 biolink:NamedThing central region of growth cone The center of the migrating motile tip of a growing nerve cell axon or dendrite. got7fsn_ti tb 2016-11-18T12:44:25Z cellular_component owl:Class
GO:0103078 biolink:NamedThing quercetin 3-rhamnoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: H+ + quercetin 3-O-rhamnoside + UDP-L-rhamnose <=> quercetin-3-rhamnoside-7-rhamnoside + UDP. got7fsn_ti RHEA:61184|MetaCyc:RXNQT-4162 molecular_function owl:Class
GO:0000412 biolink:NamedThing histone peptidyl-prolyl isomerization The modification of a histone by cis-trans isomerization of a proline residue. got7fsn_ti histone proline isomerization biological_process owl:Class
GO:0034359 biolink:NamedThing mature chylomicron A chylomicron that contains apolipoprotein C2 (APOC2), a cofactor for lipoprotein lipase (LPL) activity, and has a mean diameter of 500 nm and density of 0.95g/ml. Mature chylomicron particles transport exogenous (dietary) lipids from the intestines to other body tissues, via the blood and lymph. got7fsn_ti cellular_component owl:Class
GO:0042627 biolink:NamedThing chylomicron A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues. got7fsn_ti Wikipedia:Chylomicron cellular_component owl:Class
GO:0031805 biolink:NamedThing type 8 metabotropic glutamate receptor binding Binding to a type 8 metabotropic glutamate receptor. got7fsn_ti type 8 metabotropic glutamate receptor ligand molecular_function owl:Class
GO:0047717 biolink:NamedThing imidazoleacetate 4-monooxygenase activity Catalysis of the reaction: H(+) + imidazol-4-ylacetate + NADH + O(2) = 5-hydroxyimidazole-4-acetate + H(2)O + NAD(+). got7fsn_ti 4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating)|imidazoleacetic hydroxylase activity|imidazoleacetic monooxygenase activity|imidazoleacetate hydroxylase activity KEGG_REACTION:R04066|RHEA:19425|MetaCyc:IMIDAZOLEACETATE-4-MONOOXYGENASE-RXN|EC:1.14.13.5 molecular_function owl:Class
GO:0052833 biolink:NamedThing inositol monophosphate 4-phosphatase activity Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate. got7fsn_ti inositol-1(or 4)-monophosphatase activity|myo-inositol-1(or 4)-monophosphatase activity|myo-inositol-1(or 4)-phosphate phosphohydrolase activity ai 2011-11-29T11:02:15Z RHEA:30735|Reactome:R-HSA-1855211|MetaCyc:RXN-10952|EC:3.1.3.25 molecular_function owl:Class
GO:0052834 biolink:NamedThing inositol monophosphate phosphatase activity Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate. got7fsn_ti inositol-phosphate phosphatase activity|myo-inositol-phosphatase activity|inositol phosphatase activity|inositol-1(or 4)-monophosphatase activity|myo-inositol phosphatase activity|L-myo-inositol-phosphate phosphatase activity|myo-inositol-phosphate phosphohydrolase activity|myo-inositol monophosphatase activity|myo-inositol-1(or 4)-phosphate phosphohydrolase activity ai 2011-11-29T11:15:58Z EC:3.1.3.25|RHEA:24056|MetaCyc:RXN-10949 molecular_function owl:Class
GO:0035372 biolink:NamedThing protein localization to microtubule A process in which a protein is transported to, or maintained at, a microtubule. got7fsn_ti protein localisation to microtubule bf 2010-03-11T11:00:56Z biological_process owl:Class
GO:0072698 biolink:NamedThing protein localization to microtubule cytoskeleton A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton. got7fsn_ti protein localisation to microtubule cytoskeleton mah 2012-04-11T01:19:35Z biological_process owl:Class
GO:0021853 biolink:NamedThing cerebral cortex GABAergic interneuron migration The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex. got7fsn_ti biological_process owl:Class
GO:0021830 biolink:NamedThing interneuron migration from the subpallium to the cortex The directed movement of interneurons from the subpallium to the cortex during forebrain development. got7fsn_ti biological_process owl:Class
GO:0014023 biolink:NamedThing neural rod formation The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts. got7fsn_ti biological_process owl:Class
GO:0097665 biolink:NamedThing SCF-Mdm30 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Mdm30 in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:27:30Z cellular_component owl:Class
GO:1901511 biolink:NamedThing (-)-microperfuranone catabolic process The chemical reactions and pathways resulting in the breakdown of (-)-microperfuranone. got7fsn_ti (-)-microperfuranone catabolism|(-)-microperfuranone degradation|(-)-microperfuranone breakdown di 2012-10-18T06:54:14Z biological_process owl:Class
GO:1901502 biolink:NamedThing ether catabolic process The chemical reactions and pathways resulting in the breakdown of ether. got7fsn_ti ether breakdown|ether degradation|ether catabolism pr 2012-10-17T09:42:43Z biological_process owl:Class
GO:0035477 biolink:NamedThing regulation of angioblast cell migration involved in selective angioblast sprouting Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting. got7fsn_ti bf 2010-04-23T10:08:28Z biological_process owl:Class
GO:1901342 biolink:NamedThing regulation of vasculature development Any process that modulates the frequency, rate or extent of vasculature development. got7fsn_ti regulation of vascular system development bf 2012-09-06T09:16:15Z biological_process owl:Class
GO:0018039 biolink:NamedThing C-terminal peptidyl-glutamine amidation The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0086 biological_process owl:Class
GO:0018199 biolink:NamedThing peptidyl-glutamine modification The modification of peptidyl-glutamine. got7fsn_ti biological_process owl:Class
GO:0050362 biolink:NamedThing L-tryptophan:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate. got7fsn_ti tryptophan aminotransferase activity|L-tryptophan transaminase activity|tryptophan transaminase activity|hydroxytryptophan aminotransferase activity|L-phenylalanine-2-oxoglutarate aminotransferase activity|L-tryptophan aminotransferase activity|5-hydroxytryptophan-ketoglutaric transaminase activity MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN|RHEA:14093|EC:2.6.1.27 molecular_function owl:Class
GO:0120136 biolink:NamedThing dUMP kinase activity Catalysis of the reaction: ATP + dUMP = ADP + dUDP. got7fsn_ti dUMP-kinase activity|ATP:dUMP phosphotransferase activity|deoxyuridine monophosphate kinase activity krc 2018-03-21T21:16:06Z RHEA:30655 molecular_function owl:Class
GO:0018655 biolink:NamedThing 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA. got7fsn_ti UM-BBD_reactionID:r0430|EC:1.14.13.- molecular_function owl:Class
GO:0004771 biolink:NamedThing sterol esterase activity Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. got7fsn_ti acylcholesterol lipase activity|cholesteryl ester hydrolase activity|cholesterol esterase activity|cholesterol ester synthase activity|cholesterase activity|cholesterol ester hydrolase activity|cholesteryl esterase activity|triterpenol esterase activity|sterol ester hydrolase activity|steryl-ester acylhydrolase activity|cholesteryl ester synthase activity EC:3.1.1.13|RHEA:10100|Reactome:R-HSA-6813720|Reactome:R-HSA-8865667|Reactome:R-HSA-192417|MetaCyc:STEROL-ESTERASE-RXN molecular_function owl:Class
GO:0007280 biolink:NamedThing pole cell migration The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form. got7fsn_ti See also the Cell Ontology term 'pole cell ; CL:0000301'. biological_process owl:Class
GO:0008354 biolink:NamedThing germ cell migration The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form. got7fsn_ti primordial germ cell migration|germ-cell migration biological_process owl:Class
GO:0031316 biolink:NamedThing extrinsic component of nuclear outer membrane The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to nuclear outer membrane cellular_component owl:Class
GO:0048709 biolink:NamedThing oligodendrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system. got7fsn_ti biological_process owl:Class
GO:0010001 biolink:NamedThing glial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glial cell. got7fsn_ti neuroglia differentiation|glia cell differentiation GO:0043360|GO:0007404 biological_process owl:Class
GO:0071185 biolink:NamedThing protocadherin-alpha-v4-protocadherin-gamma-a3 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdhga1-Pcdhga3 complex mah 2009-11-23T04:16:47Z cellular_component owl:Class
GO:0071183 biolink:NamedThing protocadherin-alpha-protocadherin-gamma complex A protein complex that contains two cell adhesion molecules, a protocadherin-alpha and a protocadherin-gamma, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti mah 2009-11-23T04:10:30Z cellular_component owl:Class
GO:0004609 biolink:NamedThing phosphatidylserine decarboxylase activity Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine. got7fsn_ti PS decarboxylase activity|phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)|phosphatidyl-L-serine carboxy-lyase activity Reactome:R-HSA-1483212|RHEA:20828|EC:4.1.1.65|KEGG_REACTION:R02055|MetaCyc:PHOSPHASERDECARB-RXN molecular_function owl:Class
GO:0120120 biolink:NamedThing bilobe structure A cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone). got7fsn_ti kinetoplastid flagellar hook complex Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. krc 2017-12-11T23:47:20Z cellular_component owl:Class
GO:0120197 biolink:NamedThing mucociliary clearance The respiratory system process driven by motile cilia on epithelial cells of the respiratory tract by which mucus and associated inhaled particles and pathogens trapped within it are moved out of the airways. got7fsn_ti MCT|MCC|mucociliary transport krc 2019-04-26T16:16:50Z biological_process owl:Class
GO:0003351 biolink:NamedThing epithelial cilium movement involved in extracellular fluid movement The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid. got7fsn_ti cilium movement involved in fluid flow|epithelial cilium beating dph 2009-12-03T10:08:25Z biological_process owl:Class
GO:0042390 biolink:NamedThing gibberellic acid mediated signaling pathway, G-alpha-independent A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. got7fsn_ti gibberellic acid mediated signalling, G-alpha-independent biological_process owl:Class
GO:0009740 biolink:NamedThing gibberellic acid mediated signaling pathway A series of molecular signals mediated by the detection of gibberellic acid. got7fsn_ti GA-signaling|gibberellic acid signaling|gibberellic acid mediated signalling biological_process owl:Class
GO:0048717 biolink:NamedThing anterior cibarial plate morphogenesis The process in which the anatomical structures of the anterior cibarial plate are generated and organized. got7fsn_ti biological_process owl:Class
GO:1990403 biolink:NamedThing embryonic brain development The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure. got7fsn_ti sl 2014-06-23T20:57:13Z biological_process owl:Class
GO:0018204 biolink:NamedThing peptidyl-leucine modification The modification of peptidyl-leucine. got7fsn_ti biological_process owl:Class
GO:0018193 biolink:NamedThing peptidyl-amino acid modification The alteration of an amino acid residue in a peptide. got7fsn_ti biological_process owl:Class
GO:0046355 biolink:NamedThing mannan catabolic process The chemical reactions and pathways resulting in the breakdown of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. got7fsn_ti mannan degradation|mannan catabolism|mannan breakdown biological_process owl:Class
GO:0044247 biolink:NamedThing cellular polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells. got7fsn_ti cellular polysaccharide degradation|cellular polysaccharide catabolism|cellular polysaccharide breakdown biological_process owl:Class
GO:0052334 biolink:NamedThing modification by organism of cytoskeleton of other organism involved in symbiotic interaction The process in which an organism effects a change in the structure or function of the cytoskeleton of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modification by organism of cytoskeleton of other organism during symbiotic interaction biological_process owl:Class
GO:0052188 biolink:NamedThing modification of cellular component in other organism involved in symbiotic interaction The process in which an organism effects a change in the structure or function of a cellular component in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modification of cellular component in other organism during symbiotic interaction biological_process owl:Class
GO:0035933 biolink:NamedThing glucocorticoid secretion The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood. got7fsn_ti bf 2011-07-20T01:08:37Z biological_process owl:Class
GO:0035930 biolink:NamedThing corticosteroid hormone secretion The regulated release of any corticosteroid hormone into the circulatory system. got7fsn_ti corticosteroid secretion bf 2011-07-20T01:03:22Z biological_process owl:Class
GO:0072261 biolink:NamedThing metanephric extraglomerular mesangial cell proliferation involved in metanephros development The multiplication or reproduction of extraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. got7fsn_ti metanephric lacis cell proliferation|metanephric Goormaghtigh proliferation mah 2010-03-30T02:14:17Z biological_process owl:Class
GO:0072122 biolink:NamedThing extraglomerular mesangial cell proliferation The multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. got7fsn_ti Goormaghtigh proliferation|lacis cell proliferation mah 2010-02-22T01:42:23Z biological_process owl:Class
GO:0016445 biolink:NamedThing somatic diversification of immunoglobulins The somatic process that results in the generation of sequence diversity of immunoglobulins. got7fsn_ti somatic diversification of antibodies biological_process owl:Class
GO:0002200 biolink:NamedThing somatic diversification of immune receptors The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. got7fsn_ti Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. biological_process owl:Class
GO:0033758 biolink:NamedThing clavaminate synthase activity Catalysis of the reactions: deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 + H2O; proclavaminate + 2-oxoglutarate + O2 = dihydroclavaminate + succinate + CO2 + 2 H2O; and dihydroclavaminate + 2-oxoglutarate + O2 = clavaminate + succinate + CO2 + 2 H2O. got7fsn_ti clavaminate synthase 2 activity|clavaminic acid synthase activity|deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity RHEA:20021|EC:1.14.11.21|MetaCyc:1.14.11.21-RXN molecular_function owl:Class
GO:0061055 biolink:NamedThing myotome development The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle. got7fsn_ti dph 2010-03-02T12:11:01Z biological_process owl:Class
GO:1901343 biolink:NamedThing negative regulation of vasculature development Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development. got7fsn_ti inhibition of vasculature development|down regulation of vasculature development|downregulation of vasculature development|inhibition of vascular system development|downregulation of vascular system development|down regulation of vascular system development|down-regulation of vascular system development|down-regulation of vasculature development|negative regulation of vascular system development bf 2012-09-06T09:17:24Z biological_process owl:Class
GO:0000238 biolink:NamedThing zygotene The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Meiosis#Zygotene|Wikipedia:Zygotene biological_process owl:Class
GO:0098764 biolink:NamedThing meiosis I cell cycle phase A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0050633 biolink:NamedThing acetyl-CoA C-myristoyltransferase activity Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA. got7fsn_ti myristoyl-CoA C-acetyltransferase activity|3-oxopalmitoyl-CoA hydrolase activity|3-oxopalmitoyl-CoA-CoA acetyltransferase activity|myristoyl-CoA:acetyl-CoA C-myristoyltransferase activity MetaCyc:2.3.1.155-RXN|RHEA:18161|EC:2.3.1.155 molecular_function owl:Class
GO:0016408 biolink:NamedThing C-acyltransferase activity Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0031522 biolink:NamedThing cell envelope Sec protein transport complex A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC. got7fsn_ti Sec translocation complex|Sec complex|Sec secretion complex|plasma membrane Sec complex Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'. cellular_component owl:Class
GO:0030258 biolink:NamedThing lipid modification The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid. got7fsn_ti biological_process owl:Class
GO:0006506 biolink:NamedThing GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. got7fsn_ti glycosylphosphatidylinositol biosynthetic process|GPI anchor biosynthesis|GPI anchor formation|glycosylphosphatidylinositol biosynthesis|GPI anchor anabolism|GPI/GSI anchor biosynthesis|GPI/GSI anchor biosynthetic process|GPI anchor synthesis GO:0015998 biological_process owl:Class
GO:0006497 biolink:NamedThing protein lipidation The covalent attachment of lipid groups to an amino acid in a protein. got7fsn_ti protein amino acid lipidation|lipid:protein modification For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children. GO:0042050 RESID:AA0104|RESID:AA0159|RESID:AA0078|RESID:AA0162|RESID:AA0080|RESID:AA0106|RESID:AA0158|RESID:AA0060|RESID:AA0079|RESID:AA0307|RESID:AA0077|RESID:AA0309|RESID:AA0102|RESID:AA0308|RESID:AA0059|RESID:AA0163|RESID:AA0160|RESID:AA0161|RESID:AA0103|RESID:AA0107|RESID:AA0316|RESID:AA0166|RESID:AA0290|RESID:AA0223 biological_process owl:Class
GO:0003425 biolink:NamedThing establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate. got7fsn_ti dph 2009-12-22T10:36:36Z biological_process owl:Class
GO:0090176 biolink:NamedThing microtubule cytoskeleton organization involved in establishment of planar polarity A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity. got7fsn_ti microtubule cytoskeleton organisation involved in establishment of planar polarity tb 2009-12-14T10:34:25Z biological_process owl:Class
GO:0047649 biolink:NamedThing alkylglycerol kinase activity Catalysis of the reaction: 1-alkyl-sn-glycerol + ATP = 1-alkyl-sn-glycerol 3-phosphate + ADP + 2 H(+). got7fsn_ti 1-alkylglycerol kinase (phosphorylating)|alkylglycerol phosphotransferase activity|ATP:1-alkyl-sn-glycerol phosphotransferase activity|ATP-alkylglycerol phosphotransferase activity|ATP:1-O-alkyl-sn-glycerol 3-phosphotransferase activity MetaCyc:ALKYLGLYCEROL-KINASE-RXN|EC:2.7.1.93|KEGG_REACTION:R04126|RHEA:16937 molecular_function owl:Class
GO:0050578 biolink:NamedThing (R)-2-hydroxyacid dehydrogenase activity Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+. got7fsn_ti L-sulfolactate dehydrogenase activity|(R)-sulfolactate:NAD(P)(+) oxidoreductase activity|(R)-sulfolactate:NAD(P)+ oxidoreductase activity|(R)-2-hydroxyacid:NAD(P)+ oxidoreductase activity RHEA:35735|MetaCyc:1.1.1.272-RXN|EC:1.1.1.272 molecular_function owl:Class
GO:0000746 biolink:NamedThing conjugation The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms. got7fsn_ti Wikipedia:Conjugation biological_process owl:Class
GO:0044764 biolink:NamedThing multi-organism cellular process Any process that is carried out at the cellular level which involves another organism of the same or different species. got7fsn_ti jl 2012-12-11T17:00:50Z biological_process owl:Class
GO:0097345 biolink:NamedThing mitochondrial outer membrane permeabilization The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway. got7fsn_ti mitochondrial outer membrane permeabilization during apoptotic cell death|mitochondrion outer membrane permeabilization|MOMP|mitochondrial outer membrane permeabilization BAX and BAK are involved in this process, as reviewed in PMID:21760595 (the human proteins have UniProt symbols Q07812 and Q16611 respectively). pr 2012-06-19T04:06:54Z biological_process owl:Class
GO:1902110 biolink:NamedThing positive regulation of mitochondrial membrane permeability involved in apoptotic process Any positive regulation of mitochondrial membrane permeability that is involved in apoptotic process. got7fsn_ti positive regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity|positive regulation of transport across mitochondrial membrane involved in type I programmed cell death|mitochondrial membrane permeability transition involved in type I programmed cell death|positive regulation of mitochondrial membrane permeability involved in apoptotic cell death|positive regulation of transport across mitochondrial membrane involved in apoptotic cell death|mitochondrial permeability transition involved in apoptotic cell death|mitochondrial permeability transition involved in apoptosis|mitochondrial membrane permeabilization involved in apoptotic programmed cell death|mitochondrial membrane permeability transition involved in apoptotic process|mitochondrial membrane permeabilization involved in signaling (initiator) caspase activity|mitochondrial permeability transition involved in apoptotic programmed cell death|mitochondrial membrane permeabilization involved in apoptotic process|positive regulation of mitochondrial membrane permeability involved in apoptotic program|positive regulation of transport across mitochondrial membrane involved in apoptotic program|positive regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis|mitochondrial permeability transition involved in signaling (initiator) caspase activity|mitochondrial membrane permeability transition involved in signaling (initiator) caspase activity|mitochondrial membrane permeability transition involved in apoptotic cell death|mitochondrial membrane permeabilization involved in programmed cell death by apoptosis|positive regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death|positive regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis|mitochondrial permeability transition involved in type I programmed cell death|positive regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity|mitochondrial membrane permeability transition involved in apoptosis|mitochondrial membrane permeability transition involved in programmed cell death by apoptosis|positive regulation of transport across mitochondrial membrane involved in apoptosis|positive regulation of mitochondrial membrane permeability involved in apoptosis|mitochondrial permeability transition involved in apoptotic program|positive regulation of transport across mitochondrial membrane involved in apoptotic process|mitochondrial membrane permeabilization involved in type I programmed cell death|mitochondrial permeability transition involved in programmed cell death by apoptosis|mitochondrial membrane permeabilization involved in apoptotic program|mitochondrial membrane permeability transition involved in apoptotic program|mitochondrial membrane permeabilization involved in apoptosis|positive regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death|positive regulation of mitochondrial membrane permeability involved in type I programmed cell death|mitochondrial permeability transition involved in apoptotic process|mitochondrial membrane permeabilization involved in apoptotic cell death|mitochondrial membrane permeability transition involved in apoptotic programmed cell death Individual components of the mitochondrial permeability transition pore complex, such as the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D), are involved in this process. pr 2013-05-03T12:13:56Z biological_process owl:Class
GO:0033277 biolink:NamedThing abortive mitotic cell cycle A cell cycle in which mitosis is begun and progresses normally through the end of anaphase, but not completed, resulting in a cell with increased ploidy. got7fsn_ti abortive mitosis Note that this term should be used only for abortive mitotic events that occur normally, e.g. during megakaryocyte differentiation; it should not be used for incomplete mitosis resulting from mutation or other abnormal occurrences. Note that this term should not be confused with 'endomitotic cell cycle ; GO:0007113', which describes a process in which no mitotic spindle forms. biological_process owl:Class
GO:0000278 biolink:NamedThing mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. got7fsn_ti mitosis Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. GO:0007067 Wikipedia:Mitosis biological_process owl:Class
GO:0000721 biolink:NamedThing (R,R)-butanediol dehydrogenase activity Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+). got7fsn_ti 2,3-butanediol dehydrogenase activity|1-amino-2-propanol dehydrogenase activity|butyleneglycol dehydrogenase activity|1-amino-2-propanol oxidoreductase activity|D-1-amino-2-propanol:NAD(2) oxidoreductase activity|(R)-diacetyl reductase activity|D-aminopropanol dehydrogenase activity|D-butanediol dehydrogenase activity|D-(-)-butanediol dehydrogenase activity|aminopropanol oxidoreductase activity|butylene glycol dehydrogenase activity|D-1-amino-2-propanol dehydrogenase activity|diacetyl (acetoin) reductase activity|(R)-2,3-butanediol dehydrogenase activity MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN|EC:1.1.1.4|RHEA:24340 molecular_function owl:Class
GO:0047175 biolink:NamedThing galactosylacylglycerol O-acyltransferase activity Catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein]. got7fsn_ti acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity|acyl-ACP:lyso-MGDG acyltransferase activity|acyl-acyl-carrier protein: lysomonogalactosyldiacylglycerol acyltransferase activity RHEA:17057|MetaCyc:2.3.1.141-RXN|EC:2.3.1.141 molecular_function owl:Class
GO:0036481 biolink:NamedThing intrinsic apoptotic signaling pathway in response to hydrogen peroxide A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2). got7fsn_ti hydrogen peroxide-induced apoptosis|H2O2-induced intrinsic apoptotic signaling pathway|hydrogen peroxide-induced intrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway in response to H2O2 bf 2014-08-14T13:19:21Z biological_process owl:Class
GO:0008631 biolink:NamedThing intrinsic apoptotic signaling pathway in response to oxidative stress A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. got7fsn_ti oxidative stress-induced intrinsic apoptotic signaling pathway|induction of apoptosis by oxidative stress biological_process owl:Class
GO:0009510 biolink:NamedThing plasmodesmatal desmotubule A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell. got7fsn_ti desmotubule central rod GO:0009572 cellular_component owl:Class
GO:0034969 biolink:NamedThing histone arginine methylation The modification of a histone by addition of a methyl group to an arginine residue. got7fsn_ti biological_process owl:Class
GO:0016571 biolink:NamedThing histone methylation The modification of histones by addition of methyl groups. got7fsn_ti Wikipedia:Histone_methylation biological_process owl:Class
GO:0140536 biolink:NamedThing nuclear receptor corepressor activity A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. got7fsn_ti nuclear corepressor activity https://github.com/geneontology/go-ontology/issues/20262|https://github.com/geneontology/go-ontology/issues/20464 For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. pg 2020-11-03T13:02:08Z molecular_function owl:Class
GO:0003714 biolink:NamedThing transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. got7fsn_ti RNA polymerase II transcription corepressor activity|transcription corepressor activity|RNA polymerase II transcription co-repressor activity|transcription co-repressor activity https://github.com/geneontology/go-ontology/issues/20464|https://github.com/geneontology/go-ontology/issues/15665|https://github.com/geneontology/go-ontology/issues/15998 For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. krc 2010-11-24T03:14:44Z GO:0001106 molecular_function owl:Class
GO:0050402 biolink:NamedThing xylono-1,4-lactonase activity Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate. got7fsn_ti xylonolactonase activity|xylono-g-lactonase activity|D-xylono-1,4-lactone lactonohydrolase activity RHEA:18341|EC:3.1.1.68|MetaCyc:XYLONO-14-LACTONASE-RXN molecular_function owl:Class
GO:0060919 biolink:NamedThing auxin influx The process involved in the transport of auxin into the cell. got7fsn_ti dph 2009-09-28T02:49:18Z biological_process owl:Class
GO:0060918 biolink:NamedThing auxin transport The directed movement of auxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti dph 2009-09-28T02:44:54Z biological_process owl:Class
GO:0021905 biolink:NamedThing forebrain-midbrain boundary formation The process whose specific outcome is the creation of the forebrain-midbrain boundary. got7fsn_ti biological_process owl:Class
GO:0009308 biolink:NamedThing amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. got7fsn_ti amine metabolism biological_process owl:Class
GO:0010411 biolink:NamedThing xyloglucan metabolic process The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants. got7fsn_ti xyloglucan metabolism biological_process owl:Class
GO:0006073 biolink:NamedThing cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell. got7fsn_ti cellular glucan metabolism biological_process owl:Class
GO:0052720 biolink:NamedThing class II DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. got7fsn_ti class II DNA-(apurinic or apyrimidinic site) lyase activity https://github.com/geneontology/go-ontology/issues/13409 Class II AP endonuclease is a nuclease, but not Class I, III and IV. pg 2017-07-24T11:46:03Z GO:0140079 molecular_function owl:Class
GO:0003906 biolink:NamedThing DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). got7fsn_ti apyrimidinic deoxyendoribonuclease activity|abasic deoxyendoribonuclease activity|deoxyribonuclease (apurinic or apyrimidinic) activity|AP deoxyendoribonuclease activity|UV endonuclease|apurinic deoxyendoribonuclease activity|apurinic/apyrimidinic endodeoxyribonuclease activity|endonuclease VIII activity Reactome:R-HSA-5649725|Reactome:R-HSA-5649711|Reactome:R-HSA-110375 molecular_function owl:Class
GO:0005587 biolink:NamedThing collagen type IV trimer A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes. got7fsn_ti Wikipedia:Collagen_type_IV cellular_component owl:Class
GO:0098642 biolink:NamedThing network-forming collagen trimer A collagen trimer that forms networks. got7fsn_ti cellular_component owl:Class
GO:0070381 biolink:NamedThing endosome to plasma membrane transport vesicle A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis. got7fsn_ti endosome to plasma membrane constitutive secretory pathway transport vesicle|endosome-plasma membrane transport vesicle cellular_component owl:Class
GO:0070382 biolink:NamedThing exocytic vesicle A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. got7fsn_ti exocytic constitutive secretory pathway transport vesicle|exocytotic vesicle cellular_component owl:Class
GO:0003217 biolink:NamedThing cardiac right atrium formation The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts. got7fsn_ti dph 2009-10-13T09:53:12Z biological_process owl:Class
GO:0003210 biolink:NamedThing cardiac atrium formation The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. got7fsn_ti dph 2009-10-13T09:44:25Z biological_process owl:Class
GO:0080086 biolink:NamedThing stamen filament development The process whose specific outcome is the progression of the filament over time, from its formation to the mature structure. Filament is the stalk of a stamen. got7fsn_ti filament development dhl 2009-04-22T03:12:03Z biological_process owl:Class
GO:0042543 biolink:NamedThing protein N-linked glycosylation via arginine The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine. got7fsn_ti protein amino acid N-linked glycosylation via arginine RESID:AA0327 biological_process owl:Class
GO:0018195 biolink:NamedThing peptidyl-arginine modification The modification of peptidyl-arginine. got7fsn_ti biological_process owl:Class
GO:1990424 biolink:NamedThing protein arginine kinase activity Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate. got7fsn_ti This reaction occurs in bacterial species e.g. Bacillus subtilis. jl 2014-07-23T13:35:56Z molecular_function owl:Class
GO:0004672 biolink:NamedThing protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. got7fsn_ti protamine kinase activity Note that triphosphate is used as a phosphate donor by at least one kinase. GO:0050222 MetaCyc:PROTEIN-KINASE-RXN|Reactome:R-HSA-937034|Reactome:R-HSA-9604606|Reactome:R-HSA-9673284|Reactome:R-HSA-156832|Reactome:R-HSA-975139 molecular_function owl:Class
GO:0070427 biolink:NamedThing nucleotide-binding oligomerization domain containing 1 signaling pathway Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 1 (NOD1). got7fsn_ti nucleotide-binding oligomerization domain containing 1 signalling pathway|NOD1 signaling pathway biological_process owl:Class
GO:0070423 biolink:NamedThing nucleotide-binding oligomerization domain containing signaling pathway Any series of molecular signals generated as a consequence of binding to a nucleotide-binding oligomerization domain containing (NOD) protein. got7fsn_ti NOD signaling pathway|nucleotide-binding oligomerization domain containing signalling pathway biological_process owl:Class
GO:0003022 biolink:NamedThing detection of pH by chemoreceptor signaling The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors. got7fsn_ti detection of pH by chemoreceptor signalling biological_process owl:Class
GO:0003030 biolink:NamedThing detection of hydrogen ion The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:1990431 biolink:NamedThing priRNA 3'-end processing The process of forming the mature 3' end of a priRNA molecule. got7fsn_ti primal small RNA 3'-end processing|priRNA 3' end processing jl 2014-07-29T15:34:19Z biological_process owl:Class
GO:0043628 biolink:NamedThing ncRNA 3'-end processing Any process involved in forming the mature 3' end of a non-coding RNA molecule. got7fsn_ti ncRNA 3' end processing biological_process owl:Class
GO:0016580 biolink:NamedThing Sin3 complex A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins. got7fsn_ti cellular_component owl:Class
GO:0070822 biolink:NamedThing Sin3-type complex Any of a number of evolutionarily conserved histone deacetylase complexes (HDACs) containing a core consisting of a paired amphipathic helix motif protein (e.g. Sin3p in S. cerevisiae, Pst1 in S. pombe or Sin3A in mammals) at least one class I histone deacetylase (e.g. Rpd3p in S. cerevisiae, Clr6 in S. pombe, or HDAC1 and HDAC2 in mammals), and at least one WD40 repeat protein (e.g. Ume1p in S. cerevisiae, Prw1 in S. pombe, or RbAp46 and RbAp48 in mammals). These complexes also contain a variable number of other proteins that direct histone binding, DNA binding, or add other functionality to the complex. got7fsn_ti mah 2009-07-20T04:32:33Z cellular_component owl:Class
GO:0046455 biolink:NamedThing organosilicon catabolic process The chemical reactions and pathways resulting in the breakdown of organosilicons, any organic compound that contains silicon. got7fsn_ti organosilicon catabolism|organosilicon degradation|organosilicone catabolic process|organosilicone catabolism|organosilicon breakdown biological_process owl:Class
GO:0042178 biolink:NamedThing xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti exogenous drug catabolic process|drug catabolic process|exogenous drug catabolism|exogenous drug breakdown|drug degradation|drug catabolism|xenobiotic degradation|drug breakdown|exogenous drug degradation|xenobiotic breakdown|xenobiotic catabolism https://github.com/geneontology/go-ontology/issues/19460 GO:0042737|GO:0042738 biological_process owl:Class
GO:0035082 biolink:NamedThing axoneme assembly The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. got7fsn_ti ciliary axoneme assembly|flagellar axoneme assembly|cilium axoneme assembly|axoneme biogenesis|cilium axoneme biogenesis|flagellum axoneme assembly Note that cilia and eukaryotic flagella are deemed to be equivalent. GO:0035083|GO:0035084 biological_process owl:Class
GO:0001578 biolink:NamedThing microtubule bundle formation A process that results in a parallel arrangement of microtubules. got7fsn_ti microtubule bundling biological_process owl:Class
GO:0043209 biolink:NamedThing myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system. got7fsn_ti astrocyte sheath|Schwann cell myelin sheath|oligodendrocyte myelin sheath NIF_Subcellular:sao593830697|FMA:62983|Wikipedia:Myelin cellular_component owl:Class
GO:0043367 biolink:NamedThing CD4-positive, alpha-beta T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell. got7fsn_ti CD4-positive, alpha-beta T-cell differentiation|CD4-positive, alpha-beta T lymphocyte differentiation|CD4-positive, alpha beta T cell development|CD4-positive, alpha-beta T-lymphocyte differentiation|CD4-positive, alpha beta T cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0035710 biolink:NamedThing CD4-positive, alpha-beta T cell activation The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti bf 2011-03-02T03:04:11Z biological_process owl:Class
GO:0051881 biolink:NamedThing regulation of mitochondrial membrane potential Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti biological_process owl:Class
GO:0008024 biolink:NamedThing cyclin/CDK positive transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. got7fsn_ti positive transcription elongation factor complex b See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. cellular_component owl:Class
GO:0032806 biolink:NamedThing carboxy-terminal domain protein kinase complex A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. got7fsn_ti CTDK complex cellular_component owl:Class
GO:0047349 biolink:NamedThing D-ribitol-5-phosphate cytidylyltransferase activity Catalysis of the reaction: D-ribitol 5-phosphate + CTP = CDP-ribitol + diphosphate. got7fsn_ti CTP:D-ribitol-5-phosphate cytidylyltransferase activity|ribitol 5-phosphate cytidylyltransferase activity|cytidine diphosphoribitol pyrophosphorylase activity|CDP-ribitol diphosphorylase activity|CDP ribitol pyrophosphorylase activity|CDP-ribitol pyrophosphorylase activity|cytidine diphosphate ribitol pyrophosphorylase activity KEGG_REACTION:R02921|EC:2.7.7.40|RHEA:12456|MetaCyc:2.7.7.40-RXN molecular_function owl:Class
GO:0070567 biolink:NamedThing cytidylyltransferase activity Catalysis of the transfer of a cytidylyl group to an acceptor. got7fsn_ti mah 2009-04-15T11:05:22Z molecular_function owl:Class
GO:0072038 biolink:NamedThing mesenchymal stem cell maintenance involved in nephron morphogenesis The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti mah 2010-01-25T03:08:05Z biological_process owl:Class
GO:0035019 biolink:NamedThing somatic stem cell population maintenance Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line. got7fsn_ti biological_process owl:Class
GO:0061771 biolink:NamedThing response to caloric restriction A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake. got7fsn_ti dph 2016-07-09T09:40:32Z biological_process owl:Class
GO:0006950 biolink:NamedThing response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti response to biotic stress|response to abiotic stress Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0008544 biolink:NamedThing epidermis development The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. got7fsn_ti hypodermis development biological_process owl:Class
GO:0009888 biolink:NamedThing tissue development The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure. got7fsn_ti histogenesis|histogenesis and organogenesis Wikipedia:Histogenesis biological_process owl:Class
GO:0036409 biolink:NamedThing histone H3-K14 acetyltransferase complex A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3. got7fsn_ti histone acetyltransferase complex (H3-K14 specific)|histone H3 Lys 14 (H3K14) acetyltransferase complex|H3-K14 histone acetyltransferase complex|histone H3K14 acetyltransferase complex bf 2013-08-21T10:06:34Z cellular_component owl:Class
GO:0070775 biolink:NamedThing H3 histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histone H3. got7fsn_ti H3 HAT complex mah 2009-07-02T11:56:48Z cellular_component owl:Class
GO:0015013 biolink:NamedThing heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan. got7fsn_ti heparan sulfate proteoglycan synthesis, linkage to polypeptide|heparin proteoglycan biosynthetic process, linkage to polypeptide|heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide|heparan sulfate proteoglycan formation, linkage to polypeptide|heparan sulfate proteoglycan anabolism, linkage to polypeptide|heparan sulphate proteoglycan biosynthesis, linkage to polypeptide biological_process owl:Class
GO:0018242 biolink:NamedThing protein O-linked glycosylation via serine The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine. got7fsn_ti protein amino acid O-linked glycosylation via serine RESID:AA0154 biological_process owl:Class
GO:0035568 biolink:NamedThing N-terminal peptidyl-proline methylation The methylation of the N-terminal proline of proteins. got7fsn_ti bf 2010-08-06T01:52:43Z RESID:AA0419 biological_process owl:Class
GO:0006480 biolink:NamedThing N-terminal protein amino acid methylation The methylation of the N-terminal amino acid of a protein. got7fsn_ti biological_process owl:Class
GO:0071914 biolink:NamedThing prominosome An extracellular membrane-bounded vesicle that contains prominin proteins (in mouse Prom1/CD33 or Prom2) and are found in body fluids including ventricular fluid, saliva, urine and seminal fluid. In the ventricular fluid of the developing mouse brain two major classes of these particles have been observed (P2 particles of 500-1000 nm and P4 particles of 50-80 nm) which likely originate from microvilli, primary cilia and/or the midbody of neuroepithelial cells. The physiological role is not known. got7fsn_ti prominin-containing extracellular membrane vesicle mah 2010-09-24T09:24:36Z cellular_component owl:Class
GO:1903561 biolink:NamedThing extracellular vesicle Any vesicle that is part of the extracellular region. got7fsn_ti microparticle jl 2014-10-22T14:26:11Z cellular_component owl:Class
GO:0099000 biolink:NamedThing viral genome ejection through host cell envelope, contractile tail mechanism Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a contractile tail ejection system consisting of a baseplate, a central tube and an external contractile sheath. Upon binding to the host cell surface, the baseplate changes its conformation and triggers sheath contraction, driving the rigid internal tail tube through the cell envelope. got7fsn_ti viral contractile tail ejection system VZ:3950 biological_process owl:Class
GO:0039678 biolink:NamedThing viral genome ejection through host cell envelope Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm. got7fsn_ti viral genome injection through bacterial membranes|phage genome ejection When a pore-forming protein is involved, see also 'pore-mediated entry of viral genome into host cell ; GO:0044694'. bf 2013-09-26T11:56:48Z biological_process owl:Class
GO:0004991 biolink:NamedThing parathyroid hormone receptor activity Combining with parathyroid hormone to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0043494 biolink:NamedThing CLRC complex An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi. got7fsn_ti Rik1-E3 ubiquitin ligase complex|Clr4-Rik1-Cul4 complex|CLRC ubiquitin ligase complex|Rik1 E3 ubiquitin ligase complex cellular_component owl:Class
GO:0031465 biolink:NamedThing Cul4B-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits. got7fsn_ti cullin-RING ligase 4B cellular_component owl:Class
GO:0015667 biolink:NamedThing site-specific DNA-methyltransferase (cytosine-N4-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine. got7fsn_ti m4C-forming MTase activity|N(4)-cytosine-specific DNA methylase activity|N4-cytosine-specific DNA methylase activity|restriction-modification system activity|modification methylase activity|S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity|S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity|DNA[cytosine-N4]methyltransferase activity RHEA:16857|MetaCyc:2.1.1.113-RXN|EC:2.1.1.113 molecular_function owl:Class
GO:1990440 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. got7fsn_ti ER stress-induced upregulation of transcription|up-regulation of transcription induced by ER stress|activation of transcription from RNA polymerase II promoter in response to ER stress|up-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|upregulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|upregulation of Pol II transcription induced by ER stress|stimulation of transcription from RNA polymerase II promoter in response to ER stress bf 2014-07-31T12:56:54Z biological_process owl:Class
GO:0036003 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti bf 2011-09-19T03:00:18Z biological_process owl:Class
GO:1902106 biolink:NamedThing negative regulation of leukocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation. got7fsn_ti down regulation of leukocyte differentiation|down-regulation of leukocyte differentiation|negative regulation of immune cell differentiation|inhibition of leucocyte differentiation|down regulation of immune cell differentiation|down-regulation of leucocyte differentiation|negative regulation of leucocyte differentiation|down regulation of leucocyte differentiation|downregulation of leukocyte differentiation|inhibition of leukocyte differentiation|downregulation of immune cell differentiation|inhibition of immune cell differentiation|down-regulation of immune cell differentiation|downregulation of leucocyte differentiation pr 2013-05-02T17:32:47Z biological_process owl:Class
GO:0102925 biolink:NamedThing solanine UDP-galactose galactosyltransferase activity Catalysis of the reaction: UDP-D-galactose + solanidine = H+ + gamma-solanine + UDP. got7fsn_ti MetaCyc:RXN-8875 molecular_function owl:Class
GO:0005277 biolink:NamedThing acetylcholine transmembrane transporter activity Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. got7fsn_ti Reactome:R-HSA-264615 molecular_function owl:Class
GO:0005326 biolink:NamedThing neurotransmitter transmembrane transporter activity Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. got7fsn_ti neurotransmitter transmembrane transporter activity|neurotransmitter transporter activity Reactome:R-HSA-374919|Reactome:R-HSA-374896 molecular_function owl:Class
GO:0010498 biolink:NamedThing proteasomal protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. got7fsn_ti proteasome-mediated protein catabolic process|proteasome-mediated protein catabolism biological_process owl:Class
GO:0051603 biolink:NamedThing proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. got7fsn_ti peptidolysis involved in cellular protein catabolism|peptidolysis during cellular protein catabolic process|proteolysis during cellular protein catabolism|peptidolysis during cellular protein catabolism|proteolysis during cellular protein catabolic process|peptidolysis involved in cellular protein catabolic process biological_process owl:Class
GO:0043100 biolink:NamedThing pyrimidine nucleobase salvage Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis. got7fsn_ti pyrimidine base salvage biological_process owl:Class
GO:0008655 biolink:NamedThing pyrimidine-containing compound salvage Any process that generates a pyrimidine-containing compound, a nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis. got7fsn_ti pyrimidine salvage biological_process owl:Class
GO:0047533 biolink:NamedThing 2,5-dioxovalerate dehydrogenase (NADP+) activity Catalysis of the reaction: 2,5-dioxopentanoate + NADP+ + H2O = 2-oxoglutarate + NADPH + H+. got7fsn_ti 2-oxoglutarate semialdehyde dehydrogenase activity|alpha-ketoglutaric semialdehyde dehydrogenase activity|2,5-dioxopentanoate:NADP+ 5-oxidoreductase activity EC:1.2.1.26|MetaCyc:25-DIOXOVALERATE-DEHYDROGENASE-RXN|RHEA:11296 molecular_function owl:Class
GO:0046176 biolink:NamedThing aldonic acid catabolic process The chemical reactions and pathways resulting in the breakdown of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. got7fsn_ti aldonic acid breakdown|aldonic acid catabolism|aldonic acid degradation biological_process owl:Class
GO:0044275 biolink:NamedThing cellular carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. got7fsn_ti cellular carbohydrate degradation|cellular carbohydrate breakdown|cellular carbohydrate catabolism biological_process owl:Class
GO:0047750 biolink:NamedThing cholestenol delta-isomerase activity Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. got7fsn_ti cholestenol D-isomerase activity|delta7-cholestenol delta7-delta8-isomerase activity RHEA:15281|EC:5.3.3.5|MetaCyc:RXN66-25 molecular_function owl:Class
GO:0061274 biolink:NamedThing mesonephric distal tubule development The process whose specific outcome is the progression of the mesonephric distal tubule over time, from its formation to the mature structure. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the terminal segment of the proximal tubule and ends at the mesonephric connecting tubule. got7fsn_ti dph 2010-09-02T12:16:25Z biological_process owl:Class
GO:0072017 biolink:NamedThing distal tubule development The process whose specific outcome is the progression of the distal tubule over time, from its formation to the mature structure. In mammals, the distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. got7fsn_ti mah 2010-01-25T02:34:19Z biological_process owl:Class
GO:0005901 biolink:NamedThing caveola A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm. got7fsn_ti caveolae|caveolar membrane GO:0016599 Wikipedia:Caveolae cellular_component owl:Class
GO:0045121 biolink:NamedThing membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. got7fsn_ti GEM domain|glycolipid-enriched membrane domain|lipid raft Wikipedia:Lipid_raft cellular_component owl:Class
GO:0043622 biolink:NamedThing cortical microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell. got7fsn_ti cortical microtubule organization and biogenesis|cortical microtubule cytoskeleton organization|cortical microtubule organisation biological_process owl:Class
GO:0072678 biolink:NamedThing T cell migration The movement of a T cell within or between different tissues and organs of the body. got7fsn_ti T-cell migration|T lymphocyte migration|T-lymphocyte migration mah 2011-02-22T03:40:40Z biological_process owl:Class
GO:0097201 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter in response to stress Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti pr 2011-12-14T09:16:22Z biological_process owl:Class
GO:0043618 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to stress Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti biological_process owl:Class
GO:0061433 biolink:NamedThing cellular response to caloric restriction Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake. got7fsn_ti dph 2012-02-09T09:03:15Z biological_process owl:Class
GO:0061195 biolink:NamedThing taste bud formation The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors. got7fsn_ti dph 2010-07-27T12:22:26Z biological_process owl:Class
GO:0160004 biolink:NamedThing poly-ADP-D-ribose modification-dependent protein binding Binding to a protein upon poly-ADP-ribosylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require a poly-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. rl 2021-07-12T23:36:00Z molecular_function owl:Class
GO:0160002 biolink:NamedThing ADP-D-ribose modification-dependent protein binding Binding to a protein upon ADP-ribosylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require a ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. rl 2021-07-12T23:31:53Z molecular_function owl:Class
GO:0008332 biolink:NamedThing low voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. got7fsn_ti low voltage-dependent calcium channel activity|T-type calcium channel|low voltage gated calcium channel activity molecular_function owl:Class
GO:0005245 biolink:NamedThing voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti dihydropyridine-sensitive calcium channel activity|voltage gated calcium channel activity|depolarization-activated calcium channel|voltage-gated calcium ion channel activity|depolarization-activated voltage-gated calcium channel activity|depolarization-activated voltage-gated calcium channel|voltage-dependent calcium channel activity|voltage-sensitive calcium channel|depolarization-activated voltage gated calcium channel activity GO:0010173|GO:0015270 Reactome:R-HSA-5577213|Reactome:R-HSA-265645|Reactome:R-HSA-9701055|Reactome:R-HSA-9701141 molecular_function owl:Class
GO:0000285 biolink:NamedThing 1-phosphatidylinositol-3-phosphate 5-kinase activity Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+). got7fsn_ti ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity|phosphatidylinositol-3-phosphate 5-kinase activity|phosphatidylinositol 3-phosphate 5-kinase activity|type III PIP kinase activity Reactome:R-HSA-1676134|Reactome:R-HSA-1676168|MetaCyc:2.7.1.150-RXN|Reactome:R-HSA-1675921|KEGG_REACTION:R05802|Reactome:R-HSA-1675910|RHEA:13609|EC:2.7.1.150 molecular_function owl:Class
GO:0016307 biolink:NamedThing phosphatidylinositol phosphate kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate. got7fsn_ti phosphatidylinositol monophosphate kinase activity molecular_function owl:Class
GO:0008269 biolink:NamedThing JAK pathway signal transduction adaptor activity The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way. got7fsn_ti molecular_function owl:Class
GO:0035591 biolink:NamedThing signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. got7fsn_ti signaling scaffold activity|signalling adaptor activity https://github.com/geneontology/go-ontology/issues/19050 A signaling adaptor can bring together both protein and non-protein molecules within a signaling pathway. Scaffold proteins act in at least four ways: tethering signaling components, localizing these components to specific areas of the cell, regulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins (PMID:19104498). bf 2010-11-05T11:22:01Z molecular_function owl:Class
GO:0061359 biolink:NamedThing regulation of Wnt signaling pathway by Wnt protein secretion Any process that modulates the frequency, rate or extent of the activity of the Wnt signaling pathway by the controlled release of a Wnt protein from a cell. got7fsn_ti regulation of Wnt receptor signalling pathway by Wnt protein secretion|regulation of Wnt receptor signaling pathway by Wnt protein secretion|regulation of Wnt-activated signaling pathway by Wnt protein secretion dph 2010-10-08T01:18:02Z biological_process owl:Class
GO:0030111 biolink:NamedThing regulation of Wnt signaling pathway Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway. got7fsn_ti regulation of frizzled signalling pathway|regulation of Wnt-activated signaling pathway|regulation of Wnt receptor signaling pathway|regulation of frizzled signaling pathway|regulation of Wnt receptor signalling pathway GO:0008590 biological_process owl:Class
GO:1990464 biolink:NamedThing D-2-hydroxyacid dehydrogenase (quinone) activity Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol. got7fsn_ti D-lactate dehydrogenase activity|(R)-2-hydroxy acid dehydrogenase activity|(R)-2-hydroxyacid:quinone oxidoreductase activity|D-lactate:quinone oxidoreductase activity|(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity|D-lactate dehydrogenase (quinone) activity (R)-lactate, (R)-malate and meso-tartrate are good substrates. Ubiquinone-1 and the dye 2,6-dichloroindophenol can act as acceptors; NAD+ and NADP+ are not acceptors. pr 2014-08-22T10:13:42Z molecular_function owl:Class
GO:0016901 biolink:NamedThing oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. got7fsn_ti EC:1.1.5.- molecular_function owl:Class
GO:0008938 biolink:NamedThing nicotinate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine. got7fsn_ti furanocoumarin 8-O-methyltransferase activity|S-adenosyl-L-methionine:nicotinate N-methyltransferase activity EC:2.1.1.7|MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN|RHEA:20241|KEGG_REACTION:R01721 molecular_function owl:Class
GO:0070499 biolink:NamedThing exosporium assembly A process that is carried out at the cellular level which results in the formation of an exosporium, the outermost layer of a bacterial endospore. got7fsn_ti exosporium formation biological_process owl:Class
GO:0045229 biolink:NamedThing external encapsulating structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell. got7fsn_ti external encapsulating structure organisation|external encapsulating structure organization and biogenesis biological_process owl:Class
GO:0033438 biolink:NamedThing ACC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACC codon. got7fsn_ti threonine tRNA Note that in the standard genetic code, ACC codes for threonine. molecular_function owl:Class
GO:0030142 biolink:NamedThing COPI-coated Golgi to ER transport vesicle A vesicle that mediates transport from the Golgi to the endoplasmic reticulum. got7fsn_ti Golgi to endoplasmic reticulum transport vesicle|Golgi-ER transport vesicle|Golgi-endoplasmic reticulum transport vesicle|Golgi to ER constitutive secretory pathway transport vesicle|retrograde transport vesicle cellular_component owl:Class
GO:0030137 biolink:NamedThing COPI-coated vesicle A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport. got7fsn_ti coatomer cellular_component owl:Class
GO:0015935 biolink:NamedThing small ribosomal subunit The smaller of the two subunits of a ribosome. got7fsn_ti ribosomal small subunit cellular_component owl:Class
GO:0044391 biolink:NamedThing ribosomal subunit Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit. got7fsn_ti jl 2011-12-15T04:47:59Z cellular_component owl:Class
GO:0071152 biolink:NamedThing G-protein alpha(q)-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(q) subunit of a heterotrimeric G protein. got7fsn_ti Ric-8A G(q) alpha subunit complex mah 2009-11-16T04:48:05Z cellular_component owl:Class
GO:0008737 biolink:NamedThing L-fuculokinase activity Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+). got7fsn_ti L-fuculokinase (phosphorylating)|ATP:L-fuculose 1-phosphotransferase activity|L-fuculose kinase activity MetaCyc:FUCULOKIN-RXN|KEGG_REACTION:R03241|EC:2.7.1.51|RHEA:12376 molecular_function owl:Class
GO:0019200 biolink:NamedThing carbohydrate kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. got7fsn_ti Reactome:R-HSA-8931653 molecular_function owl:Class
GO:0044533 biolink:NamedThing positive regulation of apoptotic process in other organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism. got7fsn_ti jl 2012-03-21T11:25:24Z biological_process owl:Class
GO:0044532 biolink:NamedThing modulation of apoptotic process in other organism A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism. got7fsn_ti regulation of apoptotic process in other organism jl 2012-03-21T11:17:18Z biological_process owl:Class
GO:0043829 biolink:NamedThing tRNA-specific adenosine-37 deaminase activity Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule. got7fsn_ti TAD1|tRNA-specific adenosine deaminase 1|tRNA(Ala)-A37 deaminase activity molecular_function owl:Class
GO:0008251 biolink:NamedThing tRNA-specific adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule. got7fsn_ti tRNA-adenosine deaminase activity Reactome:R-HSA-6782336|Reactome:R-HSA-6782311 molecular_function owl:Class
GO:0040025 biolink:NamedThing vulval development The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. got7fsn_ti biological_process owl:Class
GO:0048569 biolink:NamedThing post-embryonic animal organ development Development, taking place during the post-embryonic phase of an animal tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti post-embryonic animal organogenesis biological_process owl:Class
GO:0003041 biolink:NamedThing excitation of vasomotor center by carotid body chemoreceptor signaling The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure. got7fsn_ti excitation of vasomotor center by carotid body chemoreceptor signalling biological_process owl:Class
GO:0002008 biolink:NamedThing excitation of vasomotor center by chemoreceptor signaling The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure. got7fsn_ti excitation of vasomotor center by chemoreceptor signalling biological_process owl:Class
GO:0005185 biolink:NamedThing neurohypophyseal hormone activity The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin. got7fsn_ti neurohypophysial hormone activity molecular_function owl:Class
GO:0005184 biolink:NamedThing neuropeptide hormone activity The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. got7fsn_ti neurohormone Wikipedia:Neurohormone molecular_function owl:Class
GO:0072681 biolink:NamedThing fibronectin-dependent thymocyte migration The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on fibronectin in the extracellular matrix. got7fsn_ti fibronectin-dependent immature T cell migration|fibronectin-dependent immature T-lymphocyte migration|fibronectin-dependent immature T lymphocyte migration|fibronectin-dependent immature T-cell migration|fibronectin-dependent thymic lymphocyte migration mah 2011-02-22T03:53:06Z biological_process owl:Class
GO:0072680 biolink:NamedThing extracellular matrix-dependent thymocyte migration The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development, dependent on extracellular matrix components including fibronectin, collagen and laminin. got7fsn_ti extracellular matrix-dependent thymic lymphocyte migration|extracellular matrix-dependent immature T-cell migration|extracellular matrix-dependent immature T-lymphocyte migration|extracellular matrix-dependent immature T lymphocyte migration|extracellular matrix-dependent immature T cell migration mah 2011-02-22T03:49:57Z biological_process owl:Class
GO:0047312 biolink:NamedThing L-phenylalanine:pyruvate aminotransferase activity Catalysis of the reaction: pyruvate + L-phenylalanine = phenylpyruvate + L-alanine. got7fsn_ti phenylalanine(histidine):pyruvate aminotransferase activity|L-phenylalanine:pyruvate transaminase activity|phenylalanine (histidine) aminotransferase activity|histidine aminotransferase activity|L-phenylalanine(L-histidine):pyruvate aminotransferase activity|phenylalanine(histidine) transaminase activity|L-histidine:pyruvate aminotransferase activity|phenylalanine(histidine) aminotransferase activity|histidine:pyruvate aminotransferase activity Reactome:R-HSA-893593|RHEA:13053|KEGG_REACTION:R00692|EC:2.6.1.58|MetaCyc:2.6.1.58-RXN molecular_function owl:Class
GO:0070546 biolink:NamedThing L-phenylalanine aminotransferase activity Catalysis of the transfer of an amino group from L-phenylalanine to an acceptor, usually a 2-oxo acid. got7fsn_ti molecular_function owl:Class
GO:0051882 biolink:NamedThing mitochondrial depolarization The process in which the potential difference across the mitochondrial membrane is reduced from its steady state level. got7fsn_ti mitochondrion depolarization|mitochondria depolarization|mitochondrial membrane depolarization|mitochondrial depolarisation biological_process owl:Class
GO:2000384 biolink:NamedThing negative regulation of ectoderm development Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development. got7fsn_ti vk 2011-02-15T03:17:27Z biological_process owl:Class
GO:0030741 biolink:NamedThing inositol 1-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+). got7fsn_ti myo-inositol 3-O-methyltransferase activity|inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)|S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity|inositol D-1-methyltransferase activity|S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity|inositol 3-O-methyltransferase activity|S-adenosylmethionine:myo-inositol 3-methyltransferase activity MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN|RHEA:17565|KEGG_REACTION:R01188|EC:2.1.1.40 molecular_function owl:Class
GO:0045901 biolink:NamedThing positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. got7fsn_ti up-regulation of translational elongation|activation of translational elongation|up regulation of translational elongation|stimulation of translational elongation|upregulation of translational elongation biological_process owl:Class
GO:0045727 biolink:NamedThing positive regulation of translation Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. got7fsn_ti positive regulation of protein biosynthesis|positive regulation of protein anabolism|positive regulation of protein formation|positive regulation of protein synthesis|activation of protein biosynthetic process|positive regulation of protein biosynthetic process|upregulation of protein biosynthetic process|up-regulation of protein biosynthetic process|up regulation of protein biosynthetic process|stimulation of protein biosynthetic process GO:0045946 biological_process owl:Class
GO:0044407 biolink:NamedThing single-species biofilm formation in or on host organism A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0044010 biolink:NamedThing single-species biofilm formation A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. got7fsn_ti bfp-dependent aggregation|auto-aggregation|tfp-dependent aggregation|type IV pili-dependent aggregation|bundle-forming pili-dependent aggregation|bundle-forming fimbriae-dependent aggregation https://github.com/geneontology/go-ontology/issues/18814 GO:0052000 biological_process owl:Class
GO:0085014 biolink:NamedThing dormancy entry of symbiont in host Entry into a dormant state of the symbiont within the host organism. got7fsn_ti jl 2010-05-19T02:33:26Z biological_process owl:Class
GO:0022611 biolink:NamedThing dormancy process A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated. got7fsn_ti multicellular organism dormancy process|spore dormancy process In plants and animals, dormancy may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. In plants, dormancy may involve the formation of dormant buds, and may be preceded by the senescence of plant parts such as leaves in woody plants or most of the shoot system in herbaceous perennials. The exit from dormancy in vascular plants is marked by resumed growth of buds and/or growth of vascular cambium. biological_process owl:Class
GO:0002274 biolink:NamedThing myeloid leukocyte activation A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti myeloid leucocyte activation biological_process owl:Class
GO:0045321 biolink:NamedThing leukocyte activation A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. got7fsn_ti leucocyte activation|immune cell activation Wikipedia:Immunologic_activation biological_process owl:Class
GO:0060044 biolink:NamedThing negative regulation of cardiac muscle cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation. got7fsn_ti negative regulation of heart muscle cell proliferation biological_process owl:Class
GO:0097533 biolink:NamedThing cellular stress response to acid chemical Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. got7fsn_ti cellular response to acid stress|cellular stress response to acid pr 2013-11-12T13:07:12Z biological_process owl:Class
GO:0097532 biolink:NamedThing stress response to acid chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. got7fsn_ti response to acid stress|stress response to acid pr 2013-11-12T13:04:15Z biological_process owl:Class
GO:0034599 biolink:NamedThing cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. got7fsn_ti adaptive response to oxidative stress biological_process owl:Class
GO:0004758 biolink:NamedThing serine C-palmitoyltransferase activity Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA. got7fsn_ti 3-oxosphinganine synthetase activity|SPT|serine palmitoyltransferase|acyl-CoA:serine C-2 acyltransferase decarboxylating|palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity KEGG_REACTION:R01281|EC:2.3.1.50|Reactome:R-HSA-428127|RHEA:14761|MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN molecular_function owl:Class
GO:0016454 biolink:NamedThing C-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0035244 biolink:NamedThing peptidyl-arginine C-methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein. got7fsn_ti molecular_function owl:Class
GO:0008276 biolink:NamedThing protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein. got7fsn_ti Reactome:R-HSA-9632182 molecular_function owl:Class
GO:0102620 biolink:NamedThing 3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity Catalysis of the reaction: 3-geranylgeranylindole + O2 + NADPH + H+ = 10,11-epoxy-3-geranylgeranylindole + NADP + H2O. got7fsn_ti MetaCyc:RXN-15495 molecular_function owl:Class
GO:0102867 biolink:NamedThing molybdenum cofactor sulfurtransferase activity Catalysis of the reaction: 2 H+ + MoO2-molybdopterin cofactor(2-) + L-cysteine <=> thio-molybdenum cofactor + L-alanine + H2O. got7fsn_ti MetaCyc:RXN-8351|RHEA:42636|EC:2.8.1.9 molecular_function owl:Class
GO:0046692 biolink:NamedThing sperm competition Any process that contributes to the success of sperm fertilization in multiply-mated females. got7fsn_ti Wikipedia:Sperm_competition biological_process owl:Class
GO:0048609 biolink:NamedThing multicellular organismal reproductive process The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. got7fsn_ti reproductive process in a multicellular organism|organismal reproductive process biological_process owl:Class
GO:0120077 biolink:NamedThing angiogenic sprout fusion The connection of an angiogenic sprout to another vessel or sprout during the formation of vascular networks by sprouting angiogenesis. got7fsn_ti blood vessel anastomosis|angiogenic sprout fusion https://github.com/geneontology/go-ontology/issues/13690 krc 2017-06-27T21:16:55Z biological_process owl:Class
GO:0051650 biolink:NamedThing establishment of vesicle localization The directed movement of a vesicle to a specific location. got7fsn_ti establishment of vesicle localisation biological_process owl:Class
GO:1990167 biolink:NamedThing protein K27-linked deubiquitination A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein. got7fsn_ti sp 2013-08-14T11:15:24Z biological_process owl:Class
GO:0016579 biolink:NamedThing protein deubiquitination The removal of one or more ubiquitin groups from a protein. got7fsn_ti deubiquitination|protein deubiquitylation|protein deubiquitinylation GO:0006514 biological_process owl:Class
GO:1990960 biolink:NamedThing basophil homeostasis The process of regulating the proliferation and elimination of basophils such that the total number of basophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti basophilic leucocyte homeostasis sl 2016-06-06T22:38:22Z biological_process owl:Class
GO:0002262 biolink:NamedThing myeloid cell homeostasis The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti biological_process owl:Class
GO:0006614 biolink:NamedThing SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. got7fsn_ti ER translocation|SRP-dependent cotranslational protein-membrane targeting|SRP-dependent cotranslational membrane targeting biological_process owl:Class
GO:0046352 biolink:NamedThing disaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of disaccharides, sugars composed of two monosaccharide units. got7fsn_ti disaccharide breakdown|disaccharide catabolism|disaccharide degradation biological_process owl:Class
GO:0015454 biolink:NamedThing light-driven active transmembrane transporter activity Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. got7fsn_ti light-driven pumps|Light absorption-driven transporters TC:3.E molecular_function owl:Class
GO:0015399 biolink:NamedThing primary active transmembrane transporter activity Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. got7fsn_ti primary active transporter TC:3 molecular_function owl:Class
GO:0032421 biolink:NamedThing stereocilium bundle A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes. got7fsn_ti stereocilia bundle cellular_component owl:Class
GO:0098862 biolink:NamedThing cluster of actin-based cell projections A cell part consisting of multiple, closely packed actin-based cell projections. got7fsn_ti cellular_component owl:Class
GO:0090545 biolink:NamedThing CHD-type complex A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure. got7fsn_ti tb 2013-02-15T12:11:57Z cellular_component owl:Class
GO:0070603 biolink:NamedThing SWI/SNF superfamily-type complex A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the catalytic subunit components (ATPase) and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. got7fsn_ti SWI-SNF-type complex|SWI-SNF global transcription activator complex|BAF-type complex|SWI/SNF-type complex|SWI2/SNF2 superfamily ATP-dependent chromatin remodeling complex mah 2009-04-29T12:55:46Z GO:0090544 cellular_component owl:Class
GO:0019517 biolink:NamedThing L-threonine catabolic process to D-lactate The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate. got7fsn_ti L-threonine breakdown to D-lactate|L-threonine catabolic process to methylglyoxal|L-threonine degradation to D-lactate|L-threonine catabolic process to pyruvate|L-threonine catabolic process to (R)-lactate|L-threonine catabolism to D-lactate|threonine catabolic process to D-lactate MetaCyc:THRDLCTCAT-PWY biological_process owl:Class
GO:0006567 biolink:NamedThing threonine catabolic process The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. got7fsn_ti threonine catabolism|threonine degradation|threonine breakdown MetaCyc:THREOCAT-PWY|UM-BBD_pathwayID:met biological_process owl:Class
GO:0046994 biolink:NamedThing oxidoreductase activity, acting on hydrogen as donor, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces quinone or similar compound. got7fsn_ti EC:1.12.5.- molecular_function owl:Class
GO:0050313 biolink:NamedThing sulfur dioxygenase activity Catalysis of the reaction: sulfur + O2 + H2O = sulfite. got7fsn_ti sulphur dioxygenase activity|sulfur:oxygen oxidoreductase activity|S-sulfanylglutathione:oxygen oxidoreductase activity|sulfur oxygenase activity RHEA:12981|Reactome:R-HSA-1614605|MetaCyc:FESGSHTHIO-RXN|EC:1.13.11.18 molecular_function owl:Class
GO:0043529 biolink:NamedThing GET complex An endoplasmic reticulum protein-containing complex that is conserved in eukaryotics and that mediates the insertion of tail-anchored proteins into the ER membrane. In yeast, includes Get1p, Get2p and Get3p proteins. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20244 cellular_component owl:Class
GO:0102509 biolink:NamedThing cyanidin 3,5-diglucoside glucosidase activity Catalysis of the reaction: cyanin betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose. got7fsn_ti MetaCyc:RXN-14436 molecular_function owl:Class
GO:0006949 biolink:NamedThing syncytium formation The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division. got7fsn_ti biological_process owl:Class
GO:0018133 biolink:NamedThing peptide cross-linking via L-cysteine oxazolinecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue. got7fsn_ti RESID:AA0239 biological_process owl:Class
GO:0018157 biolink:NamedThing peptide cross-linking via an oxazole or thiazole The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti peptide heterocycle biosynthesis|peptide heterocycle synthesis|peptide heterocycle biosynthetic process|peptide heterocycle formation biological_process owl:Class
GO:0009562 biolink:NamedThing embryo sac nuclear migration The directed movement of an embryo sac nucleus to the pole or center of the cell. got7fsn_ti female gametophyte nucleus migration|megagametophyte nucleus migration|embryo sac nucleus migration|megagametophyte nuclear migration|female gametophyte nuclear migration biological_process owl:Class
GO:0007097 biolink:NamedThing nuclear migration The directed movement of the nucleus to a specific location within a cell. got7fsn_ti establishment of localization of nucleus|establishment of nucleus localization|nuclear positioning|establishment of cell nucleus localization|positioning of nucleus|establishment of nucleus localisation|establishment of position of nucleus|nuclear movement|nucleus positioning|nucleus migration GO:0040023 biological_process owl:Class
GO:0052035 biolink:NamedThing positive regulation by symbiont of host inflammatory response Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti stimulation by symbiont of host inflammatory response|up regulation by symbiont of host inflammatory response|up-regulation by symbiont of host inflammatory response|positive regulation by organism of inflammatory response of other organism involved in symbiotic interaction|upregulation by symbiont of host inflammatory response|activation by symbiont of host inflammatory response GO:0052259 biological_process owl:Class
GO:0052032 biolink:NamedThing modulation by symbiont of host inflammatory response Any process in which a symbiont modulates the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of inflammatory response of other organism involved in symbiotic interaction GO:0052256 biological_process owl:Class
GO:0070021 biolink:NamedThing transforming growth factor beta ligand-receptor complex A protein complex that is formed by the association of a TGF-beta dimeric ligand with 2 molecules of each receptor molecule, TGF-beta type I receptor and TGF-beta type II receptor. The receptor molecules may form homo- or heterodimers but only once bound by the ligand. got7fsn_ti TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex|TGFbeta2 ligand-receptor complex|TGFb ligand-receptor complex|TGF-beta ligand-receptor complex|TGFbeta1-beta2 ligand-receptor complex|TGF-beta1-type II receptor-type I receptor complex|TGFbeta ligand-receptor complex|TGF-beta1-beta2 ligand-receptor complex|TGFbeta1 ligand-receptor complex|transforming growth factor beta1-type II receptor-type I receptor complex|TGF-beta2 ligand-receptor complex|TGF-beta 1:type II receptor:type I receptor complex|TGF-beta1 ligand-receptor complex cellular_component owl:Class
GO:0044271 biolink:NamedThing cellular nitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. got7fsn_ti nitrogen compound biosynthesis|nitrogen compound synthesis|nitrogen compound anabolism|nitrogen compound formation biological_process owl:Class
GO:0034528 biolink:NamedThing 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity Catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate. got7fsn_ti UM-BBD_reactionID:r0791|EC:5.3.99.- molecular_function owl:Class
GO:0008925 biolink:NamedThing maltose O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose. got7fsn_ti acetyl-CoA:maltose O-acetyltransferase activity|maltose transacetylase activity EC:2.3.1.79|RHEA:10456|MetaCyc:MALTACETYLTRAN-RXN molecular_function owl:Class
GO:0004314 biolink:NamedThing [acyl-carrier-protein] S-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]. got7fsn_ti malonyl-CoA:ACP transacylase activity|acyl-carrier-protein S-malonyltransferase activity|malonyl-CoA-acyl carrier protein transacylase activity|MCAT activity|malonyl transacylase activity|[acyl-carrier protein] S-malonyltransferase activity|malonyl transferase activity|malonyl-CoA:acyl carrier protein transacylase activity|FabD|acyl carrier proteinmalonyltransferase activity|malonyl-CoA:AcpM transacylase activity|malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity|malonyl coenzyme A-acyl carrier protein transacylase activity|MAT|acyl carrier protein malonyltransferase activity|ACP S-malonyltransferase activity MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN|Reactome:R-HSA-8933547|EC:2.3.1.39 molecular_function owl:Class
GO:0004312 biolink:NamedThing fatty acid synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. got7fsn_ti acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)|fatty-acid synthase activity RHEA:14993|EC:2.3.1.85|MetaCyc:FATTY-ACID-SYNTHASE-RXN|Reactome:R-HSA-75872 molecular_function owl:Class
GO:0050055 biolink:NamedThing limonin-D-ring-lactonase activity Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate. got7fsn_ti limonin lactone hydrolase activity|limonin-D-ring-lactone hydrolase activity|limonoate-D-ring-lactone lactonohydrolase activity MetaCyc:LIMONIN-D-RING-LACTONASE-RXN|EC:3.1.1.36|RHEA:10896 molecular_function owl:Class
GO:0052083 biolink:NamedThing suppression by symbiont of host cell-mediated immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti downregulation by symbiont of host cell-mediated immune response|down regulation by symbiont of host cell-mediated immune response|negative regulation by organism of host cell-based immune response|negative regulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction|inhibition by symbiont of host cell-mediated immune response|down-regulation by symbiont of host cell-mediated immune response GO:0052278 biological_process owl:Class
GO:0030259 biolink:NamedThing lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. got7fsn_ti biological_process owl:Class
GO:0043839 biolink:NamedThing lipid A phosphate methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A. got7fsn_ti lipid A 1-phosphomethyltransferase activity|lipid A phosphomethyltransferase activity|LmtA|lipid A methyltransferase molecular_function owl:Class
GO:0140383 biolink:NamedThing 4-hydroxytryptamine kinase activity Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H(+). got7fsn_ti pg 2019-11-20T10:30:05Z RHEA:55564|EC:2.7.1.222 molecular_function owl:Class
GO:0018594 biolink:NamedThing tert-butanol 2-monooxygenase activity Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol. got7fsn_ti tert-butyl alcohol 2-monooxygenase activity molecular_function owl:Class
GO:0016671 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. got7fsn_ti oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor EC:1.8.4.- molecular_function owl:Class
GO:0031409 biolink:NamedThing pigment binding Binding to a pigment, a general or particular coloring matter in living organisms, e.g. melanin. got7fsn_ti molecular_function owl:Class
GO:0030447 biolink:NamedThing filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. got7fsn_ti biological_process owl:Class
GO:0035853 biolink:NamedThing chromosome passenger complex localization to spindle midzone A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. got7fsn_ti chromosome passenger complex localisation to spindle midzone|chromosomal passenger complex localization to spindle midzone|CPC complex localization to spindle midzone|chromosome passenger complex localization to spindle equator|chromosome passenger complex localization to central spindle|CPC localization to spindle midzone bf 2011-05-13T01:19:51Z biological_process owl:Class
GO:0034629 biolink:NamedThing cellular protein-containing complex localization A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell. got7fsn_ti cellular protein complex localisation|establishment and maintenance of cellular protein complex localization|cellular protein complex localization biological_process owl:Class
GO:0047211 biolink:NamedThing alpha-1,4-glucan-protein synthase (ADP-forming) activity Catalysis of the reaction: ADP-D-glucose + protein = alpha-D-glucosyl-protein + ADP. got7fsn_ti ADPglucose:protein glucosyltransferase activity|ADP-glucose:protein 4-alpha-D-glucosyltransferase activity|adenosine diphosphoglucose-protein glucosyltransferase activity|1,4alpha-glucan-protein synthase (ADP-forming) activity|ADPglucose:protein 4-alpha-D-glucosyltransferase activity MetaCyc:2.4.1.113-RXN|EC:2.4.1.113 molecular_function owl:Class
GO:0060136 biolink:NamedThing embryonic process involved in female pregnancy A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother. got7fsn_ti biological_process owl:Class
GO:0102482 biolink:NamedThing 5-deoxy-D-glucuronate isomerase activity Catalysis of the reaction: 5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate. got7fsn_ti EC:5.3.1.30|RHEA:25840|MetaCyc:RXN-14150 molecular_function owl:Class
GO:0051446 biolink:NamedThing positive regulation of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle. got7fsn_ti upregulation of progression through meiotic cell cycle|positive regulation of meiotic cell cycle progression|up regulation of progression through meiotic cell cycle|stimulation of progression through meiotic cell cycle|up-regulation of progression through meiotic cell cycle|positive regulation of progression through meiotic cell cycle|activation of progression through meiotic cell cycle biological_process owl:Class
GO:0051445 biolink:NamedThing regulation of meiotic cell cycle Any process that modulates the rate or extent of progression through the meiotic cell cycle. got7fsn_ti modulation of meiotic cell cycle progression|regulation of progression through meiotic cell cycle|meiotic cell cycle modulation|meiotic cell cycle regulator|meiotic cell cycle regulation|regulation of meiotic cell cycle progression biological_process owl:Class
GO:0051328 biolink:NamedThing meiotic interphase The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA. got7fsn_ti interphase of meiotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0051325 biolink:NamedThing interphase The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs. got7fsn_ti karyostasis|resting phase Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Interphase biological_process owl:Class
GO:0006022 biolink:NamedThing aminoglycan metabolic process The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. got7fsn_ti aminoglycan metabolism biological_process owl:Class
GO:0043170 biolink:NamedThing macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti multicellular organismal macromolecule metabolic process|macromolecule metabolism|biopolymer metabolic process|organismal macromolecule metabolism GO:0043283|GO:0044259 biological_process owl:Class
GO:0090384 biolink:NamedThing phagosome-lysosome docking The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere. got7fsn_ti lysosome recruitment to phagosome tb 2010-10-27T10:24:28Z biological_process owl:Class
GO:0048278 biolink:NamedThing vesicle docking The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. got7fsn_ti vesicle to membrane docking biological_process owl:Class
GO:0001983 biolink:NamedThing baroreceptor response to increased systemic arterial blood pressure The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels. got7fsn_ti biological_process owl:Class
GO:0001978 biolink:NamedThing regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control. got7fsn_ti baroreceptor feedback control of blood pressure|baroreceptor pressure buffer system|carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure biological_process owl:Class
GO:0031017 biolink:NamedThing exocrine pancreas development The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells. got7fsn_ti biological_process owl:Class
GO:0042263 biolink:NamedThing neuropeptide F receptor activity Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa. got7fsn_ti NPF receptor activity Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related. molecular_function owl:Class
GO:0008188 biolink:NamedThing neuropeptide receptor activity Combining with a neuropeptide to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0102654 biolink:NamedThing 1-18:1-2-16:0-phosphatidylglycerol trans-3 desaturase activity Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:1-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-1725|RHEA:46764|EC:1.14.19.43 molecular_function owl:Class
GO:0033914 biolink:NamedThing xylan 1,3-beta-xylosidase activity Catalysis of the hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans. got7fsn_ti 1,3-beta-D-xylosidase, exo-1,3-beta-xylosidase activity|1,3-beta-D-xylan xylohydrolase activity|exo-1,3-beta-xylosidase activity|beta-1,3'-xylanase activity|exo-beta-1,3'-xylanase activity MetaCyc:3.2.1.72-RXN|EC:3.2.1.72 molecular_function owl:Class
GO:0097599 biolink:NamedThing xylanase activity Catalysis of the hydrolysis of xylans, homopolysaccharides composed of xylose residues. got7fsn_ti xylosidase activity pr 2014-05-06T13:46:48Z molecular_function owl:Class
GO:0102362 biolink:NamedThing esculetin 3-O-glucosyltransferase activity Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 3-O-beta-D-glucosyl-esculetin + UDP + H+. got7fsn_ti MetaCyc:RXN-13472 molecular_function owl:Class
GO:0021970 biolink:NamedThing corticospinal neuron axon guidance through the basilar pons The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues. got7fsn_ti corticospinal neuron axon pathfinding through the basilar pons biological_process owl:Class
GO:0001863 biolink:NamedThing collectin receptor activity Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). molecular_function owl:Class
GO:0001847 biolink:NamedThing opsonin receptor activity Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0046739 biolink:NamedThing transport of virus in multicellular host The transport of a virus between cells in a multicellular organism. The cells can be adjacent or spatially separated (e.g. in different tissues or organs). got7fsn_ti spread of virus in multicellular host|spread of virus within multicellular host|viral spread within multicellular host biological_process owl:Class
GO:0044000 biolink:NamedThing movement in host The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti movement of symbiont within host|movement of symbiont in host|symbiont movement in host|symbiont movement within host|movement within host biological_process owl:Class
GO:0072014 biolink:NamedThing proximal tubule development The process whose specific outcome is the progression of the proximal tubule over time, from its formation to the mature structure. In mammals, the proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology. got7fsn_ti mah 2010-01-25T02:33:46Z biological_process owl:Class
GO:0072080 biolink:NamedThing nephron tubule development The progression of a nephron tubule over time, from its initial formation to the mature structure. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. got7fsn_ti mah 2010-02-01T02:32:12Z biological_process owl:Class
SO:0000673 biolink:NamedThing got7fsn_ti owl:Class
CHEBI:33697 biolink:NamedThing got7fsn_ti owl:Class
GO:0075119 biolink:NamedThing induction by symbiont of host G protein-coupled receptor signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host signal transduction mediated by G-protein beta subunit|positive regulation by symbiont of host G-protein coupled receptor protein signal transduction|positive regulation by symbiont of host signal transduction mediated by G-protein gamma subunit|positive regulation by symbiont of host G protein-coupled receptor signal transduction|positive regulation by symbiont of host signal transduction mediated by G-protein alpha subunit Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by symbiont of host G protein-coupled receptor signal transduction ; GO:0075088". GO:0075128|GO:0075125|GO:0075122 biological_process owl:Class
GO:0021716 biolink:NamedThing inferior olivary nucleus structural organization The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. got7fsn_ti inferior olivary nucleus structural organisation|inferior olive structural organization biological_process owl:Class
GO:0000707 biolink:NamedThing meiotic DNA recombinase assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA. got7fsn_ti biological_process owl:Class
GO:0061982 biolink:NamedThing meiosis I cell cycle process A process that contributes to the first meiotic division. The first meiotic division is the reductive division resulting in the separation of homologous chromosome pairs. got7fsn_ti first meiotic cell division dph 2018-02-14T22:27:20Z biological_process owl:Class
GO:0042043 biolink:NamedThing neurexin family protein binding Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. got7fsn_ti neuroligin GO:0019963 molecular_function owl:Class
GO:0005102 biolink:NamedThing signaling receptor binding Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. got7fsn_ti receptor binding|receptor ligand|receptor-associated protein activity Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. Wikipedia:Ligand_(biochemistry) molecular_function owl:Class
GO:0103081 biolink:NamedThing methylthiopropylmalate dehydrogenase activity Catalysis of the reaction: 3-(3'-methylthio)propylmalate <=> H+ + 2-oxo-6-methylthiohexanoate + carbon dioxide. got7fsn_ti MetaCyc:RXNQT-4165 molecular_function owl:Class
GO:0045296 biolink:NamedThing cadherin binding Binding to cadherin, a type I membrane protein involved in cell adhesion. got7fsn_ti molecular_function owl:Class
GO:0050839 biolink:NamedThing cell adhesion molecule binding Binding to a cell adhesion molecule. got7fsn_ti adhesive extracellular matrix constituent|cell adhesion molecule activity|cell adhesion receptor activity|CAM binding molecular_function owl:Class
GO:0048878 biolink:NamedThing chemical homeostasis Any biological process involved in the maintenance of an internal steady state of a chemical. got7fsn_ti biological_process owl:Class
GO:0018366 biolink:NamedThing chiral amino acid racemization The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid. got7fsn_ti biological_process owl:Class
GO:0006520 biolink:NamedThing cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. got7fsn_ti cellular amino acid metabolism|amino acid and derivative metabolism|cellular amino acid and derivative metabolic process|amino acid metabolic process GO:0006519 biological_process owl:Class
GO:0036441 biolink:NamedThing 2-dehydropantolactone reductase activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. got7fsn_ti bf 2013-09-30T16:26:27Z RHEA:18981|KEGG_REACTION:R03155 molecular_function owl:Class
GO:0019664 biolink:NamedThing mixed acid fermentation The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP. got7fsn_ti glucose catabolic process to mixed acids|glucose fermentation to mixed acids Wikipedia:Mixed_acid_fermentation biological_process owl:Class
GO:0019660 biolink:NamedThing glycolytic fermentation Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. got7fsn_ti MetaCyc:Pyruvate-Degredation biological_process owl:Class
GO:0140502 biolink:NamedThing effector-mediated suppression of host salicylic acid-mediated innate immune signalling A process mediated by a molecule secreted by a symbiont that results in the suppression of host salicylic acid-mediated innate immune signalling. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19848 pg 2020-08-11T06:16:36Z biological_process owl:Class
GO:0071546 biolink:NamedThing pi-body A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes. got7fsn_ti intermitochondrial cement mah 2010-01-12T05:44:12Z cellular_component owl:Class
GO:0043186 biolink:NamedThing P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. got7fsn_ti germline granule|nuage|polar granule GO:0018994 cellular_component owl:Class
GO:0005009 biolink:NamedThing insulin-activated receptor activity Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti insulin receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand insulin. For receptors that bind other extracellular ligands, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class
GO:0004714 biolink:NamedThing transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. got7fsn_ti receptor protein tyrosine kinase activity|receptor protein-tyrosine kinase activity Reactome:R-HSA-8987096|Reactome:R-HSA-8950423|Reactome:R-HSA-8986985|Reactome:R-HSA-8987070|EC:2.7.10.1|Reactome:R-HSA-8987042|Reactome:R-HSA-8950340|Reactome:R-HSA-8983300|Reactome:R-HSA-8987084|Reactome:R-HSA-8987012|Reactome:R-HSA-8950757|Reactome:R-HSA-8983309|Reactome:R-HSA-8950591|Reactome:R-HSA-8987040|Reactome:R-HSA-74742|Reactome:R-HSA-169905|Reactome:R-HSA-8983424|Reactome:R-HSA-8853792|Reactome:R-HSA-8987150|Reactome:R-HSA-8986995|Reactome:R-HSA-8987255|Reactome:R-HSA-8982163|Reactome:R-HSA-8950364|Reactome:R-HSA-8950537|Reactome:R-HSA-74715|Reactome:R-HSA-8987202|Reactome:R-HSA-74711|Reactome:R-HSA-8986994|Reactome:R-HSA-8983371|Reactome:R-HSA-167019|Reactome:R-HSA-8950405|Reactome:R-HSA-8987179|Reactome:R-HSA-8987141|Reactome:R-HSA-177933|Reactome:R-HSA-8987129|Reactome:R-HSA-198295|Reactome:R-HSA-8852552|Reactome:R-HSA-8950354|Reactome:R-HSA-8950269|Reactome:R-HSA-167683|Reactome:R-HSA-6784324|Reactome:R-HSA-166544|Reactome:R-HSA-8950485|Reactome:R-HSA-8950453|MetaCyc:2.7.10.1-RXN molecular_function owl:Class
GO:0038170 biolink:NamedThing somatostatin signaling pathway The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti somatostatin signalling pathway|SRIF signaling pathway|somatostatin-mediated signaling pathway|somatostatin-activated somatostatin receptor signaling pathway|SST signaling pathway|somatotrophin release inhibiting factor signaling pathway bf 2012-06-12T10:33:21Z biological_process owl:Class
GO:0098593 biolink:NamedThing goblet cell theca A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium. It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel. got7fsn_ti dos 2014-03-11T14:52:33Z cellular_component owl:Class
GO:0060036 biolink:NamedThing notochord cell vacuolation The assembly and arrangement of a vacuole within a cell of the notochord. got7fsn_ti biological_process owl:Class
GO:0007033 biolink:NamedThing vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. got7fsn_ti vacuole biogenesis|vacuole organization and biogenesis|vacuole organisation|vacuolar assembly GO:0044086 biological_process owl:Class
GO:0000460 biolink:NamedThing maturation of 5.8S rRNA Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0006364 biolink:NamedThing rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. got7fsn_ti 35S primary transcript processing GO:0006365 biological_process owl:Class
GO:0097329 biolink:NamedThing response to antimetabolite Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. got7fsn_ti pr 2012-06-12T10:52:01Z biological_process owl:Class
GO:0034552 biolink:NamedThing respiratory chain complex II assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II. got7fsn_ti biological_process owl:Class
GO:0002421 biolink:NamedThing B cell antigen processing and presentation following pinocytosis B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. got7fsn_ti B-cell antigen processing and presentation following pinocytosis|B-lymphocyte antigen processing and presentation following pinocytosis|B lymphocyte antigen processing and presentation following pinocytosis biological_process owl:Class
GO:0035855 biolink:NamedThing megakaryocyte development The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow. got7fsn_ti megakaryocyte cell development bf 2011-05-13T01:28:06Z biological_process owl:Class
GO:0061515 biolink:NamedThing myeloid cell development The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure. got7fsn_ti dph 2013-04-18T13:03:16Z biological_process owl:Class
GO:0051778 biolink:NamedThing ent-7-alpha-hydroxykaurenoate oxidase activity Catalysis of the reaction: ent-7-alpha-hydroxykaurenoate + NADPH + H+ + O2 = gibberellin 12-aldehyde + NADP+ + 2 H2O. This is the second of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). got7fsn_ti Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. MetaCyc:RXN1F-160|RHEA:22904 molecular_function owl:Class
GO:0030144 biolink:NamedThing alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors. got7fsn_ti UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity|alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyltransferase V activity|UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity|GnTV activity|alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity|alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity EC:2.4.1.155|MetaCyc:2.4.1.155-RXN|Reactome:R-HSA-975916|Reactome:R-HSA-9696980|RHEA:16921 molecular_function owl:Class
GO:0060955 biolink:NamedThing neural crest-derived cardiac glial cell fate commitment The commitment of neural crest cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells. got7fsn_ti dph 2009-09-29T03:15:04Z biological_process owl:Class
GO:0060953 biolink:NamedThing cardiac glial cell fate commitment The commitment of cells to cardiac glial cell fates and their capacity to differentiate into cardiac glial cells. got7fsn_ti dph 2009-09-29T03:11:23Z biological_process owl:Class
GO:0019487 biolink:NamedThing anaerobic acetylene catabolic process The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen. got7fsn_ti anaerobic acetylene catabolism|anaerobic acetylene degradation|anaerobic ethyne catabolic process|anaerobic ethyne catabolism|anaerobic acetylene breakdown MetaCyc:P161-PWY biological_process owl:Class
GO:0043454 biolink:NamedThing alkyne catabolic process The chemical reactions and pathways resulting in the breakdown of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2. got7fsn_ti alkyne breakdown|alkyne catabolism|alkyne degradation biological_process owl:Class
GO:0060535 biolink:NamedThing trachea cartilage morphogenesis The process in which the anatomical structures of cartilage in the trachea are generated and organized. got7fsn_ti dph 2009-04-10T09:07:48Z biological_process owl:Class
GO:0060536 biolink:NamedThing cartilage morphogenesis The process in which the anatomical structures of cartilage are generated and organized. got7fsn_ti dph 2009-04-10T09:13:27Z biological_process owl:Class
GO:0071197 biolink:NamedThing Kv4.2-Kv4.3 channel complex A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3. got7fsn_ti mah 2009-11-23T05:00:33Z CORUM:609 cellular_component owl:Class
GO:0008076 biolink:NamedThing voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. got7fsn_ti voltage-sensitive potassium channel complex|voltage gated potassium channel complex|voltage-dependent potassium channel complex NIF_Subcellular:sao371494298 cellular_component owl:Class
GO:0010557 biolink:NamedThing positive regulation of macromolecule biosynthetic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biological_process owl:Class
GO:0010556 biolink:NamedThing regulation of macromolecule biosynthetic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biological_process owl:Class
GO:0062141 biolink:NamedThing nuclear exosome targeting complex A protein-containing complex that functions with the RNA exosome and contributes to the degradation of abberant transcripts. got7fsn_ti NEXT complex dph 2019-08-29T14:46:59Z cellular_component owl:Class
GO:0097641 biolink:NamedThing alpha-ketoglutarate-dependent xanthine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate. got7fsn_ti alpha-ketoglutarate- and Fe(II)-dependent xanthine hydroxylase activity|alpha-ketoglutarate- and Fe(II)-dependent xanthine dioxygenase activity|2-oxoglutarate-dependent xanthine dioxygenase activity pr 2014-09-03T14:55:42Z RHEA:43120 molecular_function owl:Class
GO:0006513 biolink:NamedThing protein monoubiquitination Addition of a single ubiquitin group to a protein. got7fsn_ti protein monoubiquitylation|protein monoubiquitinylation biological_process owl:Class
GO:0016567 biolink:NamedThing protein ubiquitination The process in which one or more ubiquitin groups are added to a protein. got7fsn_ti protein ubiquitinylation|protein ubiquitylation biological_process owl:Class
GO:0106310 biolink:NamedThing protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20114 Note that this term is to annotate proteins the specifically phosphorylate a serine residue on a protein. An example is human PIKFYVE (UniProt:Q9Y2I7). For dual specificity protein kinases, use 'protein serine/threonine kinase activity' ; GO:0004712. hjd 2020-09-22T20:01:17Z RHEA:17989 molecular_function owl:Class
GO:0034772 biolink:NamedThing histone H4-K20 dimethylation The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone. got7fsn_ti histone lysine H4 K20 dimethylation|histone H4 K20 dimethylation biological_process owl:Class
GO:0018027 biolink:NamedThing peptidyl-lysine dimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine. got7fsn_ti RESID:AA0075 biological_process owl:Class
GO:0070415 biolink:NamedThing trehalose metabolism in response to cold stress The chemical reactions and pathways involving trehalose that occur as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. got7fsn_ti trehalose metabolic process involved in response to cold stress biological_process owl:Class
GO:0070413 biolink:NamedThing trehalose metabolism in response to stress The chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress. got7fsn_ti trehalose metabolic process involved in response to stress biological_process owl:Class
GO:0036094 biolink:NamedThing small molecule binding Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule. got7fsn_ti Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. bf 2012-01-17T04:20:34Z molecular_function owl:Class
GO:0034656 biolink:NamedThing nucleobase-containing small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. got7fsn_ti nucleobase, nucleoside and nucleotide catabolism|nucleobase, nucleoside and nucleotide degradation|nucleobase, nucleoside and nucleotide breakdown biological_process owl:Class
GO:0102521 biolink:NamedThing tRNA-4-demethylwyosine synthase activity Catalysis of the reaction: pyruvate + S-adenosyl-L-methionine + N1-methylguanine37 in tRNAPhe = L-methionine + 5'-deoxyadenosine + carbon dioxide + H2O + 4-demethylwyosine37 in tRNAPhe. got7fsn_ti EC:4.1.3.44|MetaCyc:RXN-14516|RHEA:36347 molecular_function owl:Class
GO:0002346 biolink:NamedThing B cell positive selection Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor. got7fsn_ti B lymphocyte positive selection|B-lymphocyte positive selection|B-cell positive selection biological_process owl:Class
GO:0002339 biolink:NamedThing B cell selection The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival. got7fsn_ti B-cell selection|B lymphocyte selection|B-lymphocyte selection biological_process owl:Class
GO:0035220 biolink:NamedThing wing disc development Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura. got7fsn_ti biological_process owl:Class
GO:0007444 biolink:NamedThing imaginal disc development The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.). got7fsn_ti biological_process owl:Class
GO:0047495 biolink:NamedThing membrane-oligosaccharide glycerophosphotransferase activity Catalysis of the transfer of a glycerophospho group from one membrane-derived oligosaccharide to another. got7fsn_ti periplasmic phosphoglycerotransferase activity|membrane-derived-oligosaccharide-6-(glycerophospho)-D-glucose:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity|phosphoglycerol cyclase activity MetaCyc:2.7.8.21-RXN|EC:2.7.8.21 molecular_function owl:Class
GO:0016035 biolink:NamedThing zeta DNA polymerase complex A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer. got7fsn_ti cellular_component owl:Class
GO:0046912 biolink:NamedThing acyltransferase, acyl groups converted into alkyl on transfer Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. got7fsn_ti transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer https://github.com/geneontology/go-ontology/issues/20486 EC:2.3.3.- molecular_function owl:Class
GO:0000266 biolink:NamedThing mitochondrial fission The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. got7fsn_ti mitochondrial proliferation|mitochondrial division biological_process owl:Class
GO:0007005 biolink:NamedThing mitochondrion organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. got7fsn_ti mitochondrion organization and biogenesis|mitochondria organization|mitochondrion organisation biological_process owl:Class
GO:0006874 biolink:NamedThing cellular calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. got7fsn_ti regulation of calcium ion concentration biological_process owl:Class
GO:0006875 biolink:NamedThing cellular metal ion homeostasis Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell. got7fsn_ti cellular heavy metal ion homeostasis biological_process owl:Class
GO:0016125 biolink:NamedThing sterol metabolic process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. got7fsn_ti sterol metabolism biological_process owl:Class
GO:0043726 biolink:NamedThing 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate. got7fsn_ti pyrimidine phosphatase activity GO:0019173 MetaCyc:RIBOPHOSPHAT-RXN|RHEA:25197 molecular_function owl:Class
GO:0006036 biolink:NamedThing cuticle chitin catabolic process The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. got7fsn_ti cuticle chitin breakdown|cuticle chitin catabolism|cuticle chitin degradation biological_process owl:Class
GO:0006032 biolink:NamedThing chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. got7fsn_ti beta-1,4-linked N-acetylglucosamine catabolic process|chitin breakdown|chitin degradation|chitin catabolism|beta-1,4-linked N-acetylglucosamine catabolism biological_process owl:Class
GO:0045204 biolink:NamedThing MAPK export from nucleus The directed movement of a MAP kinase from the nucleus to the cytoplasm. got7fsn_ti MAPK-nucleus export|MAPK export out of nucleus|MAPK export from cell nucleus|MAPK transport from nucleus to cytoplasm|cytoplasmic translocation of mitogen-activated protein kinase|cytoplasmic translocation of MAP kinase biological_process owl:Class
GO:0006611 biolink:NamedThing protein export from nucleus The directed movement of a protein from the nucleus into the cytoplasm. got7fsn_ti protein export out of nucleus|protein transport from nucleus to cytoplasm|protein export from cell nucleus|protein-nucleus export|copper-induced protein export from nucleus GO:0097349 biological_process owl:Class
GO:0050959 biolink:NamedThing echolocation Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning. got7fsn_ti perception of environment using reflected sound waves|biological sonar Wikipedia:Echolocation biological_process owl:Class
GO:0050877 biolink:NamedThing nervous system process A organ system process carried out by any of the organs or tissues of neurological system. got7fsn_ti neurophysiological process|pan-neural process|neurological system process https://github.com/geneontology/go-ontology/issues/13824 biological_process owl:Class
GO:1904058 biolink:NamedThing positive regulation of sensory perception of pain Any process that activates or increases the frequency, rate or extent of sensory perception of pain. got7fsn_ti upregulation of sensory perception of pain|positive regulation of perception of physiological pain|activation of nociception|activation of sensory perception of pain|up-regulation of perception of physiological pain|up-regulation of sensory perception of pain|up regulation of sensory perception of pain|up regulation of nociception|upregulation of perception of physiological pain|positive regulation of nociception|upregulation of nociception|up regulation of perception of physiological pain|activation of perception of physiological pain|up-regulation of nociception sl 2015-03-18T20:34:03Z biological_process owl:Class
GO:0051930 biolink:NamedThing regulation of sensory perception of pain Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. got7fsn_ti biological_process owl:Class
GO:0036509 biolink:NamedThing trimming of terminal mannose on B branch The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. got7fsn_ti conversion of (Man)9(GlcNAc)2 to (Man)8B(GlcNAc)2|conversion of M9 to M8B|glycoprotein mannose trimming on B branch Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. bf 2015-06-11T14:02:44Z KEGG_REACTION:R06722 biological_process owl:Class
GO:1904380 biolink:NamedThing endoplasmic reticulum mannose trimming Any protein alpha-1,2-demannosylation that takes place in the endoplasmic reticulum quality control compartment (ERQC). got7fsn_ti protein alpha-1,2-demannosylation in ER|protein alpha-1,2-demannosylation in endoplasmic reticulum|glycoprotein mannose trimming in endoplasmic reticulum quality control compartment|protein alpha-1,2-demannosylation in endoplasmic reticulum quality control compartment|ER protein alpha-1,2-demannosylation|protein alpha-1,2-demannosylation in ER-derived quality control compartment|glycoprotein mannose trimming in ERQC|protein alpha-1,2-demannosylation in ER quality control compartment|glycoprotein mannose trimming in ER-derived quality control compartment|ER mannose trimming|glycoprotein mannose trimming in ER quality control compartment|protein alpha-1,2-demannosylation in ERQC bf 2015-06-23T09:35:41Z biological_process owl:Class
GO:1900046 biolink:NamedThing regulation of hemostasis Any process that modulates the frequency, rate or extent of hemostasis. got7fsn_ti jl 2012-01-19T03:23:38Z biological_process owl:Class
GO:0002519 biolink:NamedThing natural killer cell tolerance induction Tolerance induction of natural killer cells. got7fsn_ti NK cell tolerance induction biological_process owl:Class
GO:0002507 biolink:NamedThing tolerance induction A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. got7fsn_ti biological_process owl:Class
GO:0072417 biolink:NamedThing response to spindle checkpoint signaling A process that occurs in response to signals generated as a result of spindle checkpoint signaling. got7fsn_ti response to signal involved in spindle checkpoint|spindle checkpoint effector process mah 2010-12-08T03:56:04Z biological_process owl:Class
GO:0072396 biolink:NamedThing response to cell cycle checkpoint signaling A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling. got7fsn_ti response to signal involved in G1/S transition checkpoint|response to G2/M transition checkpoint signaling|cell cycle checkpoint effector process|G2/M transition checkpoint effector process|response to signal involved in cell cycle checkpoint|response to G1/S transition checkpoint signaling|G1/S transition checkpoint effector process|response to signal involved in G2/M transition checkpoint mah 2010-12-08T03:05:46Z GO:0072405|GO:0072408 biological_process owl:Class
GO:0005451 biolink:NamedThing monovalent cation:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). got7fsn_ti monovalent cation:hydrogen antiporter activity Reactome:R-HSA-2889070 molecular_function owl:Class
GO:0005141 biolink:NamedThing interleukin-10 receptor binding Binding to an interleukin-10 receptor. got7fsn_ti interleukin-10 receptor ligand|IL-10 molecular_function owl:Class
GO:0019982 biolink:NamedThing interleukin-7 binding Binding to interleukin-7. got7fsn_ti IL-7 binding molecular_function owl:Class
GO:0090493 biolink:NamedThing catecholamine uptake The directed movement of catecholamine into a cell. got7fsn_ti tb 2012-10-17T11:06:17Z biological_process owl:Class
GO:0051937 biolink:NamedThing catecholamine transport The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. got7fsn_ti biological_process owl:Class
GO:0071227 biolink:NamedThing cellular response to molecule of oomycetes origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin. got7fsn_ti cellular response to oomycetes associated molecule mah 2009-12-03T01:55:09Z biological_process owl:Class
GO:1990200 biolink:NamedThing SsuD-SsuE complex A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation. got7fsn_ti two-component alkanesulfonate monooxygenase system bhm 2013-10-03T12:59:26Z cellular_component owl:Class
GO:0039684 biolink:NamedThing rolling circle single-stranded viral DNA replication A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome. got7fsn_ti ssDNA rolling circle replication bf 2013-10-17T14:15:48Z VZ:1941 biological_process owl:Class
GO:0039682 biolink:NamedThing rolling circle viral DNA replication A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA. got7fsn_ti bf 2013-10-17T14:13:51Z biological_process owl:Class
GO:0008682 biolink:NamedThing 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone. got7fsn_ti demethoxyubiquinone monooxygenase|demethoxy-ubiquinone hydroxylase RHEA:50908|EC:1.14.99.60|MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN molecular_function owl:Class
GO:0004497 biolink:NamedThing monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. got7fsn_ti hydroxylase activity Reactome:R-HSA-211910|Reactome:R-HSA-211962|Reactome:R-HSA-5662692|Reactome:R-HSA-6786239|Reactome:R-HSA-76456|Reactome:R-HSA-76354|Reactome:R-HSA-2161814|Reactome:R-HSA-211988|Reactome:R-HSA-213175|Reactome:R-HSA-9018874|Reactome:R-HSA-9027042|Reactome:R-HSA-143468|Reactome:R-HSA-215526|Reactome:R-HSA-156526|Reactome:R-HSA-76373|Reactome:R-HSA-211959|Reactome:R-HSA-76426|Reactome:R-HSA-5423678|Reactome:R-HSA-211948|Reactome:R-HSA-5423672|Reactome:R-HSA-211924|Reactome:R-HSA-2161795|Reactome:R-HSA-5605147|Reactome:R-HSA-217258|Reactome:R-HSA-9037761|Reactome:R-HSA-2161899|Reactome:R-HSA-9027321|Reactome:R-HSA-5662662|Reactome:R-HSA-76386|Reactome:R-HSA-76466|Reactome:R-HSA-76416|Reactome:R-HSA-212004|Reactome:R-HSA-211960|Reactome:R-HSA-2161940|Reactome:R-HSA-211919|Reactome:R-HSA-5423664|Reactome:R-HSA-76472|Reactome:R-HSA-76475|Reactome:R-HSA-76434|Reactome:R-HSA-211968|Reactome:R-HSA-212005|Reactome:R-HSA-211991|Reactome:R-HSA-5602272|Reactome:R-HSA-2162191|Reactome:R-HSA-211882|Reactome:R-HSA-9027043|Reactome:R-HSA-211951|Reactome:R-HSA-76397|Reactome:R-HSA-5423647|Reactome:R-HSA-9027044|Reactome:R-HSA-9027302|Reactome:R-HSA-5602242|Reactome:R-HSA-5602295|Reactome:R-HSA-211904|Reactome:R-HSA-2161890|Reactome:R-HSA-5663050|Reactome:R-HSA-8865107|Reactome:R-HSA-211929 molecular_function owl:Class
GO:0031205 biolink:NamedThing endoplasmic reticulum Sec complex An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex. got7fsn_ti cellular_component owl:Class
GO:0031946 biolink:NamedThing regulation of glucocorticoid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. got7fsn_ti biological_process owl:Class
GO:0090030 biolink:NamedThing regulation of steroid hormone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. got7fsn_ti tb 2009-08-03T10:38:27Z biological_process owl:Class
GO:0045821 biolink:NamedThing positive regulation of glycolytic process Any process that activates or increases the frequency, rate or extent of glycolysis. got7fsn_ti upregulation of glycolysis|stimulation of glycolysis|activation of glycolysis|up-regulation of glycolysis|up regulation of glycolysis biological_process owl:Class
GO:0031331 biolink:NamedThing positive regulation of cellular catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. got7fsn_ti stimulation of cellular catabolic process|up-regulation of cellular catabolic process|positive regulation of cellular degradation|positive regulation of cellular breakdown|activation of cellular catabolic process|upregulation of cellular catabolic process|up regulation of cellular catabolic process|positive regulation of cellular catabolism biological_process owl:Class
GO:0003976 biolink:NamedThing UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose. got7fsn_ti UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity|N-acetylglucosaminylphosphotransferase activity|lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity|UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity|N-acetylglucosaminyl phosphotransferase activity|UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity|UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity|UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity MetaCyc:2.7.8.17-RXN|EC:2.7.8.17|RHEA:13581 molecular_function owl:Class
GO:0032302 biolink:NamedThing MutSbeta complex A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. got7fsn_ti MMR complex|MSH2/MSH3 complex cellular_component owl:Class
GO:0031157 biolink:NamedThing regulation of aggregate size involved in sorocarp development Any process that modulates the size of the aggregate formed during sorocarp formation. got7fsn_ti regulation of aggregation during fruiting body formation|regulation of aggregation during fruiting body biosynthesis biological_process owl:Class
GO:0047025 biolink:NamedThing 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity Catalysis of the reaction: NAD+ + OH-acyl-[acyl-carrier protein] = NADH + H+ + B-ketoacyl-[acyl-carrier protein]. got7fsn_ti 3-oxoacyl-acyl-carrier-protein reductase (NADH)|3-oxoacyl-ACP reductase (NADH) activity|3-oxoacyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide) reductase activity|3-oxoacyl-[acyl-carrier protein] reductase (NADH) activity|(3R)-3-hydroxyacyl-acyl-carrier-protein:NAD+ oxidoreductase activity EC:1.1.1.212|MetaCyc:1.1.1.212-RXN|RHEA:19913 molecular_function owl:Class
GO:0090060 biolink:NamedThing regulation of metaxylem development Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed. got7fsn_ti tb 2009-08-11T03:14:54Z biological_process owl:Class
GO:2000026 biolink:NamedThing regulation of multicellular organismal development Any process that modulates the frequency, rate or extent of multicellular organismal development. got7fsn_ti tb 2010-08-05T11:25:59Z biological_process owl:Class
GO:0052103 biolink:NamedThing induction by symbiont of host induced systemic resistance Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti induction by organism of induced systemic resistance in other organism involved in symbiotic interaction|induction by symbiont of induced systemic resistance in host|up-regulation by symbiont of induced systemic resistance in host|positive regulation by organism of induced systemic resistance in other organism involved in symbiotic interaction|up regulation by symbiont of induced systemic resistance in host|positive regulation by symbiont of host induced systemic resistance|activation by symbiont of induced systemic resistance in host|upregulation by symbiont of induced systemic resistance in host|stimulation by symbiont of induced systemic resistance in host|positive regulation by symbiont of induced systemic resistance in host|activation by organism of ISR in host|activation by organism of induced systemic resistance in host|induction by organism of ISR in host GO:0052532|GO:0052533|GO:0052288 biological_process owl:Class
GO:0052159 biolink:NamedThing modulation by symbiont of host induced systemic resistance Any process in which a symbiont modulates the frequency, rate or extent of induced systemic resistance in the host organism; induced systemic resistance is a response that confers broad spectrum systemic resistance to disease and that does not depend upon salicylic acid signaling. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of induced systemic resistance in host|modulation by organism of induced systemic resistance in other organism involved in symbiotic interaction GO:0052298 biological_process owl:Class
GO:0001571 biolink:NamedThing non-tyrosine kinase fibroblast growth factor receptor activity Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity. got7fsn_ti non-tyrosine kinase FGF receptor activity|non-tyrosine kinase FGFR activity molecular_function owl:Class
GO:1904362 biolink:NamedThing regulation of calcitonin secretion Any process that modulates the frequency, rate or extent of calcitonin secretion. got7fsn_ti sl 2015-06-15T17:54:52Z biological_process owl:Class
GO:0090276 biolink:NamedThing regulation of peptide hormone secretion Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. got7fsn_ti tb 2010-02-05T02:56:39Z biological_process owl:Class
GO:0044403 biolink:NamedThing biological process involved in symbiotic interaction A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts. got7fsn_ti commensalism|symbiotic interaction between organisms|parasitism|symbiotic interaction|symbiosis|symbiotic interaction between species|symbiotic interaction between host and organism|host-pathogen interaction|symbiotic process|symbiosis, encompassing mutualism through parasitism https://github.com/geneontology/go-ontology/issues/14807|https://github.com/geneontology/go-ontology/issues/20191 GO:0072519|GO:0085031|GO:0043298|GO:0044404 biological_process owl:Class
GO:0044419 biolink:NamedThing biological process involved in interspecies interaction between organisms Any process evolved to enable an interaction with an organism of a different species. got7fsn_ti interspecies interaction|interaction with another species|interspecies interaction between organisms|interspecies interaction with other organisms https://github.com/geneontology/go-ontology/issues/20191 biological_process owl:Class
GO:0045049 biolink:NamedThing protein insertion into ER membrane by N-terminal cleaved signal sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER. got7fsn_ti protein insertion into endoplasmic reticulum membrane by N-terminal cleaved signal sequence|N-terminal cleaved signal sequence mediated protein insertion into ER membrane|protein insertion into ER membrane, N-terminal cleaved signal sequence mediated|protein-endoplasmic reticulum insertion by N-terminal cleaved signal sequence|protein-ER insertion by N-terminal cleaved signal sequence biological_process owl:Class
GO:0045048 biolink:NamedThing protein insertion into ER membrane The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane. got7fsn_ti positioning of protein in ER membrane|integral ER membrane protein localization|integral ER membrane protein positioning|protein insertion into endoplasmic reticulum membrane|localization of protein in ER membrane|protein-ER insertion|protein-endoplasmic reticulum insertion biological_process owl:Class
GO:0034918 biolink:NamedThing 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0930 molecular_function owl:Class
GO:0097341 biolink:NamedThing zymogen inhibition Any process that prevents the proteolytic processing of an inactive enzyme to an active form. got7fsn_ti prevention of zymogen activation pr 2012-06-18T11:25:45Z biological_process owl:Class
GO:0010955 biolink:NamedThing negative regulation of protein processing Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage. got7fsn_ti negative regulation of protein maturation by peptide bond cleavage tb 2009-04-27T12:10:19Z biological_process owl:Class
GO:0045105 biolink:NamedThing intermediate filament polymerization or depolymerization Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament. got7fsn_ti biological_process owl:Class
GO:0043933 biolink:NamedThing protein-containing complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. got7fsn_ti protein complex subunit organization|macromolecular complex organization|cellular macromolecular complex subunit organisation|macromolecular complex subunit organisation|protein complex subunit organisation|cellular macromolecular complex organization|cellular macromolecular complex subunit organization|macromolecular complex subunit organization mah 2010-09-08T10:01:42Z GO:0034600|GO:0071822|GO:0034621 biological_process owl:Class
GO:0071747 biolink:NamedThing IgA B cell receptor complex An IgA immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti membrane-bound IgA1|surface IgA1|surface IgA|membrane-bound IgA2|membrane-bound IgA|surface IgA2 Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0071745 biolink:NamedThing IgA immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgA1 antibody|IgA2 antibody Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0048790 biolink:NamedThing maintenance of presynaptic active zone structure A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters. got7fsn_ti maintenance of pre-synaptic active zone structure biological_process owl:Class
GO:1990709 biolink:NamedThing presynaptic active zone organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone. got7fsn_ti presynaptic active zone organisation pr 2015-03-20T10:16:24Z biological_process owl:Class
GO:0097100 biolink:NamedThing supercoiled DNA binding Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. got7fsn_ti pr 2011-07-12T03:28:57Z molecular_function owl:Class
GO:0003690 biolink:NamedThing double-stranded DNA binding Binding to double-stranded DNA. got7fsn_ti dsDNA binding molecular_function owl:Class
GO:0008174 biolink:NamedThing mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. got7fsn_ti molecular_function owl:Class
GO:0018132 biolink:NamedThing peptide cross-linking via L-cysteine oxazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti RESID:AA0238 biological_process owl:Class
GO:0010796 biolink:NamedThing regulation of multivesicular body size Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles. got7fsn_ti biological_process owl:Class
GO:0051036 biolink:NamedThing regulation of endosome size Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. got7fsn_ti endosome enlargement biological_process owl:Class
GO:0043171 biolink:NamedThing peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. got7fsn_ti peptide breakdown|peptide degradation|peptide catabolism biological_process owl:Class
GO:0044248 biolink:NamedThing cellular catabolic process The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. got7fsn_ti cellular breakdown|cellular catabolism|cellular degradation biological_process owl:Class
GO:0033564 biolink:NamedThing anterior/posterior axon guidance The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. got7fsn_ti anterior-posterior axon guidance|anterior/posterior axon pathfinding biological_process owl:Class
GO:0044065 biolink:NamedThing regulation of respiratory system process Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. got7fsn_ti biological_process owl:Class
GO:0043576 biolink:NamedThing regulation of respiratory gaseous exchange Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment. got7fsn_ti biological_process owl:Class
GO:0071372 biolink:NamedThing cellular response to follicle-stimulating hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. got7fsn_ti cellular response to follicle stimulating hormone stimulus|cellular response to FSH stimulus mah 2009-12-11T03:15:56Z biological_process owl:Class
GO:0032354 biolink:NamedThing response to follicle-stimulating hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus. got7fsn_ti response to follicle-stimulating hormone stimulus|response to FSH stimulus|response to follicle stimulating hormone stimulus biological_process owl:Class
GO:0071217 biolink:NamedThing cellular response to external biotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. got7fsn_ti mah 2009-12-03T01:14:27Z biological_process owl:Class
GO:0071216 biolink:NamedThing cellular response to biotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. got7fsn_ti cellular response to biotic stress Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. mah 2009-12-03T01:09:08Z biological_process owl:Class
GO:0002014 biolink:NamedThing vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system. got7fsn_ti biological_process owl:Class
GO:0042310 biolink:NamedThing vasoconstriction A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. got7fsn_ti negative regulation of blood vessel size GO:0045908 Wikipedia:Vasoconstriction biological_process owl:Class
GO:0009432 biolink:NamedThing SOS response An error-prone process for repairing damaged microbial DNA. got7fsn_ti Wikipedia:SOS_response biological_process owl:Class
GO:0006974 biolink:NamedThing cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. got7fsn_ti response to genotoxic stress|cellular DNA damage response|DNA damage response|response to DNA damage stimulus GO:0034984 biological_process owl:Class
GO:0032574 biolink:NamedThing 5'-3' RNA helicase activity Unwinding of an RNA helix in the 5' to 3' direction, driven by ATP hydrolysis. got7fsn_ti ATP-dependent 5'-3' RNA helicase activity|ATP-dependent 5' to 3' RNA helicase activity|5' to 3' RNA helicase activity https://github.com/geneontology/go-ontology/issues/21612 GO:0032575 Reactome:R-HSA-9694265|Reactome:R-HSA-9682695 molecular_function owl:Class
GO:0003724 biolink:NamedThing RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis. got7fsn_ti ATP-dependent RNA helicase activity https://github.com/geneontology/go-ontology/issues/21612 GO:0004004 EC:3.6.4.13|Reactome:R-HSA-72647|MetaCyc:ADENOSINETRIPHOSPHATASE-RXN molecular_function owl:Class
GO:0043011 biolink:NamedThing myeloid dendritic cell differentiation The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin. got7fsn_ti Wikipedia:Dendritic_cell biological_process owl:Class
GO:0001773 biolink:NamedThing myeloid dendritic cell activation The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti biological_process owl:Class
GO:1990626 biolink:NamedThing mitochondrial outer membrane fusion The membrane organization process that joins two mitochondrial outer membranes to form a single membrane. got7fsn_ti mitochondrion outer membrane fusion vw 2015-02-02T11:32:17Z biological_process owl:Class
GO:0007366 biolink:NamedThing periodic partitioning by pair rule gene Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities. got7fsn_ti biological_process owl:Class
GO:0007365 biolink:NamedThing periodic partitioning The regionalization process that divides the spatial regions of an embryo into serially repeated regions. got7fsn_ti Note that examples of periodic partitions are tagmata, segments or parasegments. biological_process owl:Class
GO:0031414 biolink:NamedThing N-terminal protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule. got7fsn_ti NAT complex cellular_component owl:Class
GO:0031248 biolink:NamedThing protein acetyltransferase complex A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule. got7fsn_ti cellular_component owl:Class
GO:0043752 biolink:NamedThing adenosylcobinamide kinase activity Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP). got7fsn_ti AdoCbi kinase/AdoCbi-phosphate guanylyltransferase|CobU|RTP:adenosylcobinamide phosphotransferase activity|adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase MetaCyc:2.7.1.156-RXN|EC:2.7.1.156 molecular_function owl:Class
GO:0000986 biolink:NamedThing bacterial-type cis-regulatory region sequence-specific DNA binding Binding to a specific upstream cis-regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the promoter of a bacterial gene (or cistron, or operon). got7fsn_ti eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding|bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding|bacterial-type proximal promoter sequence-specific DNA binding|bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding|bacterial-type RNA polymerase enhancer sequence-specific DNA binding krc 2011-01-27T03:42:53Z GO:0001150 molecular_function owl:Class
GO:0000984 biolink:NamedThing bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding Binding to a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. got7fsn_ti eubacterial-type RNA polymerase regulatory region DNA binding|eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding|bacterial-type RNA polymerase regulatory region DNA binding To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. krc 2010-08-10T02:58:18Z GO:0001017 molecular_function owl:Class
GO:0039656 biolink:NamedThing modulation by virus of host gene expression The process in which a virus effects a change in gene expression in its host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. got7fsn_ti regulation by virus of host gene expression bf 2013-06-20T15:28:26Z biological_process owl:Class
GO:0090409 biolink:NamedThing malonyl-CoA synthetase activity Catalysis of the reaction: malonate + ATP + coenzyme A = malonyl-CoA + AMP + diphosphate. got7fsn_ti tb 2011-06-10T01:51:16Z MetaCyc:RXN-12359|RHEA:32139|EC:6.2.1.n3 molecular_function owl:Class
GO:1990059 biolink:NamedThing fruit valve development The process whose specific outcome is the progression of the fruit valve over time, from its formation to the mature structure. The fruit valve is a part of a fruit that splits apart when the fruit dehisces. got7fsn_ti dhl 2013-03-12T21:21:15Z biological_process owl:Class
GO:0035454 biolink:NamedThing extrinsic component of stromal side of plastid inner membrane The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region. got7fsn_ti peripheral to stromal side of plastid inner membrane|extrinsic to stromal leaflet of plastid inner membrane|extrinsic to stromal side of plastid inner membrane bf 2010-04-16T10:23:12Z cellular_component owl:Class
GO:0035453 biolink:NamedThing extrinsic component of plastid inner membrane The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to plastid inner membrane|peripheral to plastid inner membrane bf 2010-04-16T10:21:14Z cellular_component owl:Class
GO:0042745 biolink:NamedThing circadian sleep/wake cycle The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. got7fsn_ti biological_process owl:Class
GO:0048512 biolink:NamedThing circadian behavior The specific behavior of an organism that recurs with a regularity of approximately 24 hours. got7fsn_ti circadian rhythm behavior biological_process owl:Class
GO:0043703 biolink:NamedThing photoreceptor cell fate determination The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0048664 biolink:NamedThing neuron fate determination The process in which a cell becomes capable of differentiating autonomously into a neuron regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0044496 biolink:NamedThing negative regulation of blood pressure in other organism A process by which one organism decreases the force with which blood travels through the circulatory system of another organism. got7fsn_ti jl 2012-02-01T02:15:28Z biological_process owl:Class
GO:0106385 biolink:NamedThing dIMP salvage Any process which produces a dIMP from derivatives of it, without de novo synthesis. got7fsn_ti hjd 2021-06-11T20:03:19Z biological_process owl:Class
GO:0043094 biolink:NamedThing cellular metabolic compound salvage Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells. got7fsn_ti biological_process owl:Class
GO:0061409 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to freezing Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius. got7fsn_ti dph 2012-01-12T12:11:06Z biological_process owl:Class
GO:0071497 biolink:NamedThing cellular response to freezing Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. got7fsn_ti ice nucleation inhibitor activity|antifreeze activity mah 2009-12-18T02:41:02Z biological_process owl:Class
GO:0006703 biolink:NamedThing estrogen biosynthetic process The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. got7fsn_ti estrogen biosynthesis|oestrogen biosynthetic process|oestrogen biosynthesis|estrogen anabolism|estrogen formation|estrogen synthesis biological_process owl:Class
GO:0042638 biolink:NamedThing exogen The shedding phase of the hair cycle. got7fsn_ti hair shedding Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0044851 biolink:NamedThing hair cycle phase The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). jl 2014-07-16T14:22:09Z biological_process owl:Class
GO:0072254 biolink:NamedThing metanephric glomerular mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the metanephros as it progresses from its formation to the mature state. got7fsn_ti mah 2010-03-19T04:04:02Z biological_process owl:Class
GO:0072209 biolink:NamedThing metanephric mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the metanephros as it progresses from its formation to the mature state. got7fsn_ti mah 2010-03-18T11:56:44Z biological_process owl:Class
GO:0097122 biolink:NamedThing cyclin A2-CDK1 complex A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:42:24Z cellular_component owl:Class
GO:0000307 biolink:NamedThing cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. got7fsn_ti CDK holoenzyme cellular_component owl:Class
GO:0018000 biolink:NamedThing N-terminal peptidyl-tyrosine acetylation The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine. got7fsn_ti RESID:AA0053 biological_process owl:Class
GO:0006474 biolink:NamedThing N-terminal protein amino acid acetylation The acetylation of the N-terminal amino acid of proteins. got7fsn_ti N(alpha)-terminal acetylation biological_process owl:Class
GO:0044020 biolink:NamedThing histone methyltransferase activity (H4-R3 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4. got7fsn_ti histone methylase activity (H4-R3 specific)|histone-arginine N-methyltransferase activity (H4-R3 specific) molecular_function owl:Class
GO:0008469 biolink:NamedThing histone-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine. got7fsn_ti histone methyltransferase activity|histone-arginine N-methylase activity|S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity|histone protein methylase activity|nuclear protein (histone) N-methyltransferase activity|histone protein methylase I|S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity|protein methylase I activity GO:0016276 Reactome:R-HSA-8937113|Reactome:R-HSA-5205799|Reactome:R-HSA-8936584|Reactome:R-HSA-8936608|Reactome:R-HSA-5661117|Reactome:R-HSA-5216234|Reactome:R-HSA-5205861|Reactome:R-HSA-8937022 molecular_function owl:Class
GO:0050810 biolink:NamedThing regulation of steroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. got7fsn_ti regulation of steroid synthesis|regulation of steroid formation|regulation of steroid biosynthesis|regulation of steroid anabolism|regulation of steroidogenesis biological_process owl:Class
GO:0090079 biolink:NamedThing translation regulator activity, nucleic acid binding Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. got7fsn_ti tb 2009-10-19T10:19:05Z molecular_function owl:Class
GO:0045182 biolink:NamedThing translation regulator activity Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. got7fsn_ti translation factor activity molecular_function owl:Class
GO:0070040 biolink:NamedThing rRNA (adenine-C2-)-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2503) in 23S rRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + rRNA containing C2-methyladenine(2503) in 23S rRNA. got7fsn_ti MetaCyc:RXN-11586|EC:2.1.1.192 molecular_function owl:Class
GO:0008169 biolink:NamedThing C-methyltransferase activity Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule. got7fsn_ti EC:2.1.1.- molecular_function owl:Class
GO:0097504 biolink:NamedThing Gemini of coiled bodies Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). got7fsn_ti Gems pr 2013-09-24T15:20:12Z cellular_component owl:Class
GO:0140440 biolink:NamedThing protein-cysteine S-oleoyltransferase activity Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-[protein]. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18882 pg 2020-03-11T09:56:11Z RHEA:59744 molecular_function owl:Class
GO:0019707 biolink:NamedThing protein-cysteine S-acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18882 RHEA:63372 molecular_function owl:Class
GO:0060736 biolink:NamedThing prostate gland growth The increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state. got7fsn_ti dph 2009-06-15T09:21:52Z biological_process owl:Class
GO:0031695 biolink:NamedThing alpha-2B adrenergic receptor binding Binding to an alpha-2B adrenergic receptor. got7fsn_ti alpha-2B adrenergic receptor ligand molecular_function owl:Class
GO:0031690 biolink:NamedThing adrenergic receptor binding Binding to an adrenergic receptor. got7fsn_ti adrenergic receptor ligand molecular_function owl:Class
GO:0072573 biolink:NamedThing tolerance induction to lipopolysaccharide Tolerance induction directed at lipopolysaccharide antigens. got7fsn_ti tolerance induction to LPS|tolerance induction to endotoxin mah 2011-02-02T03:05:19Z biological_process owl:Class
GO:0045171 biolink:NamedThing intercellular bridge A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised. got7fsn_ti cellular_component owl:Class
GO:0052080 biolink:NamedThing modulation by symbiont of host innate immune response MAPK kinase signaling Any process in which an organism modulates the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|modulation of defense-related host mitogen activated protein kinase-mediated signal transduction pathway by organism|modulation of defense-related host MAPK-mediated signal transduction pathway by organism|modulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction https://github.com/geneontology/go-ontology/issues/19235 GO:0052277 biological_process owl:Class
GO:0052031 biolink:NamedThing modulation by symbiont of host defense response Any process in which an organism modulates the frequency, rate or extent of the defense response of its host, the response mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti mitigation by symbiont of host defense response|pathogenesis|modulation by organism of defense response of other organism involved in symbiotic interaction GO:0052255 biological_process owl:Class
GO:0071771 biolink:NamedThing aldehyde decarbonylase activity Catalysis of the reaction: a C(n) aldehyde = C(n-1) alkane + CO. got7fsn_ti decarbonylase activity mah 2010-04-01T12:02:50Z molecular_function owl:Class
GO:0009856 biolink:NamedThing pollination The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion. got7fsn_ti Wikipedia:Pollination biological_process owl:Class
GO:0048102 biolink:NamedThing autophagic cell death A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells. got7fsn_ti programmed cell death by macroautophagy|autophagic death|autosis|programmed cell death by autophagy|type II programmed cell death The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not. biological_process owl:Class
GO:0012501 biolink:NamedThing programmed cell death A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. got7fsn_ti caspase-independent apoptosis|RCD|nonapoptotic programmed cell death|PCD|non-apoptotic programmed cell death|caspase-independent cell death|regulated cell death Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. GO:0016244 Wikipedia:Programmed_cell_death biological_process owl:Class
GO:0001664 biolink:NamedThing G protein-coupled receptor binding Binding to a G protein-coupled receptor. got7fsn_ti G protein coupled receptor binding|G protein coupled receptor ligand|G-protein coupled receptor binding|G-protein-coupled receptor ligand Reactome:R-HSA-500717 molecular_function owl:Class
GO:0007270 biolink:NamedThing neuron-neuron synaptic transmission The process of synaptic transmission from a neuron to another neuron across a synapse. got7fsn_ti nerve-nerve synaptic transmission biological_process owl:Class
GO:0007268 biolink:NamedThing chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. got7fsn_ti neurotransmission|signal transmission across a synapse|synaptic transmission Wikipedia:Neurotransmission biological_process owl:Class
GO:0032802 biolink:NamedThing low-density lipoprotein particle receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. got7fsn_ti LDL receptor catabolic process|low-density lipoprotein receptor breakdown|LDL receptor degradation|low-density lipoprotein receptor degradation|LDL receptor breakdown|low-density lipoprotein receptor catabolism|low-density lipoprotein receptor catabolic process|LDL receptor catabolism biological_process owl:Class
GO:0032799 biolink:NamedThing low-density lipoprotein receptor particle metabolic process The chemical reactions and pathways involving low-density lipoprotein receptors. got7fsn_ti low-density lipoprotein receptor metabolism|LDL receptor metabolic process|low-density lipoprotein receptor metabolic process biological_process owl:Class
GO:0019036 biolink:NamedThing viral transcriptional complex Specific locations and structures in the virus infected cell involved in transcribing the viral genome. got7fsn_ti cellular_component owl:Class
GO:0030311 biolink:NamedThing poly-N-acetyllactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. got7fsn_ti poly-N-acetyllactosamine biosynthesis|poly-N-acetyllactosamine synthesis|poly-N-acetyllactosamine anabolism|poly-N-acetyllactosamine formation biological_process owl:Class
GO:0050413 biolink:NamedThing D-alanine 2-hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine. got7fsn_ti 5,10-methylenetetrahydrofolate:D-alanine 2-hydroxymethyltransferase activity|2-methylserine hydroxymethyltransferase activity|D-alanine hydroxymethyltransferase activity RHEA:10064|KEGG_REACTION:R01225|EC:2.1.2.7|MetaCyc:D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0016742 biolink:NamedThing hydroxymethyl-, formyl- and related transferase activity Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). got7fsn_ti EC:2.1.2.- molecular_function owl:Class
GO:0097672 biolink:NamedThing SCF-Pof5 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae). got7fsn_ti SCF-YDR306C ubiquitin ligase complex pr 2014-10-06T10:30:10Z cellular_component owl:Class
GO:0009966 biolink:NamedThing regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. got7fsn_ti regulation of signaling pathway|regulation of signalling pathway GO:0035466 biological_process owl:Class
GO:0048754 biolink:NamedThing branching morphogenesis of an epithelial tube The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder. got7fsn_ti tubulogenesis biological_process owl:Class
GO:0061138 biolink:NamedThing morphogenesis of a branching epithelium The process in which the anatomical structures of a branched epithelium are generated and organized. got7fsn_ti dph 2010-05-25T09:05:34Z biological_process owl:Class
GO:0070158 biolink:NamedThing mitochondrial seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA in a mitochondrion, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0030350 biolink:NamedThing iron-responsive element binding Binding to an iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins. got7fsn_ti IRE binding molecular_function owl:Class
GO:0003729 biolink:NamedThing mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. got7fsn_ti base pairing with mRNA GO:0000499 molecular_function owl:Class
GO:0072148 biolink:NamedThing epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an epithelial cell. got7fsn_ti mah 2010-02-24T02:05:03Z biological_process owl:Class
GO:0048105 biolink:NamedThing establishment of body hair planar orientation Orientation of body hairs, projections from the surface of an organism, such that the hairs all point in a uniform direction along the surface. got7fsn_ti biological_process owl:Class
GO:0048104 biolink:NamedThing establishment of body hair or bristle planar orientation Orientation of hairs or sensory bristles that cover the body surface of an adult, such that they all point in a uniform direction along the plane of the epithelium from which they project. got7fsn_ti biological_process owl:Class
GO:0002463 biolink:NamedThing central tolerance induction to nonself antigen Tolerance induction to nonself antigens in the central lymphoid organs. got7fsn_ti biological_process owl:Class
GO:0002508 biolink:NamedThing central tolerance induction Tolerance induction in the central lymphoid organs: the thymus and bone marrow. got7fsn_ti biological_process owl:Class
GO:0016004 biolink:NamedThing phospholipase activator activity Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. got7fsn_ti molecular_function owl:Class
GO:0060229 biolink:NamedThing lipase activator activity Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. got7fsn_ti molecular_function owl:Class
GO:0044865 biolink:NamedThing negative regulation by virus of host cell division Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division. got7fsn_ti inhibition by virus of host cell division jl 2014-08-05T16:31:44Z biological_process owl:Class
GO:0051782 biolink:NamedThing negative regulation of cell division Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. got7fsn_ti down regulation of cell division|inhibition of cell division|down-regulation of cell division|downregulation of cell division biological_process owl:Class
GO:0070590 biolink:NamedThing spore wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore. got7fsn_ti mah 2009-04-28T01:06:10Z biological_process owl:Class
GO:0042546 biolink:NamedThing cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. got7fsn_ti cell wall assembly biological_process owl:Class
GO:0002080 biolink:NamedThing acrosomal membrane The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization. got7fsn_ti cellular_component owl:Class
GO:0046630 biolink:NamedThing gamma-delta T cell proliferation The expansion of a gamma-delta T cell population by cell division. got7fsn_ti gamma-delta T-lymphocyte proliferation|gamma-delta T lymphocyte proliferation|gamma-delta T-cell proliferation biological_process owl:Class
GO:0007209 biolink:NamedThing phospholipase C-activating tachykinin receptor signaling pathway The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). got7fsn_ti activation of phospholipase C activity by tachykinin receptor signalling pathway|activation of phospholipase C activity by tachykinin receptor signaling pathway|tachykinin receptor, phospholipase C activating pathway biological_process owl:Class
GO:0007217 biolink:NamedThing tachykinin receptor signaling pathway The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor. got7fsn_ti tachykinin signalling pathway biological_process owl:Class
GO:0009707 biolink:NamedThing chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. got7fsn_ti chloroplast outer envelope cellular_component owl:Class
GO:0031969 biolink:NamedThing chloroplast membrane Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope. got7fsn_ti Wikipedia:Chloroplast_membrane cellular_component owl:Class
GO:0071138 biolink:NamedThing alpha5-beta5-fibronectin-SFRP2 complex A protein complex that consists of an alpha5-beta5 integrin complex bound to fibronectin and secreted frizzled-related protein 2. got7fsn_ti ITGA5-ITGB5-FN-1-SFRP2 complex mah 2009-11-13T02:30:31Z cellular_component owl:Class
GO:0003179 biolink:NamedThing heart valve morphogenesis The process in which the structure of a heart valve is generated and organized. got7fsn_ti heart valve remodeling|heart valve remodelling dph 2009-10-08T11:23:48Z biological_process owl:Class
GO:0043136 biolink:NamedThing glycerol-3-phosphatase activity Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate. got7fsn_ti Reactome:R-HSA-8955794|MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN molecular_function owl:Class
GO:0019752 biolink:NamedThing carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). got7fsn_ti carboxylic acid metabolism biological_process owl:Class
GO:1990357 biolink:NamedThing terminal web An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells. got7fsn_ti pr 2014-04-03T14:29:59Z cellular_component owl:Class
GO:0030864 biolink:NamedThing cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0000131 biolink:NamedThing incipient cellular bud site The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence. got7fsn_ti cellular_component owl:Class
GO:0017197 biolink:NamedThing N-terminal peptidyl-proline acetylation The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline. got7fsn_ti RESID:AA0050 biological_process owl:Class
GO:0018208 biolink:NamedThing peptidyl-proline modification The modification of peptidyl-proline. got7fsn_ti biological_process owl:Class
GO:0000772 biolink:NamedThing mating pheromone activity The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted. got7fsn_ti molecular_function owl:Class
GO:0005186 biolink:NamedThing pheromone activity The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant. got7fsn_ti Also consider annotating to 'receptor agonist activity ; GO:0048018'. molecular_function owl:Class
GO:0033778 biolink:NamedThing 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity Catalysis of the reaction: 7alpha-hydroxycholest-4-en-3-one + H(+) + NADPH + O(2) = 7alpha,12alpha-dihydroxycholest-4-en-3-one + H(2)O + NADP(+). got7fsn_ti HCO 12alpha-hydroxylase activity|7alpha-hydroxycholest-4-en-3-one,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity|sterol 12alpha-hydroxylase activity|7alpha-hydroxy-4-cholesten-3-one 12alpha-monooxygenase activity|CYP12 Reactome:R-HSA-193709|EC:1.14.14.139|KEGG_REACTION:R04826|MetaCyc:1.14.13.95-RXN|Reactome:R-HSA-193845|Reactome:R-HSA-192157|RHEA:10504 molecular_function owl:Class
GO:0016533 biolink:NamedThing protein kinase 5 complex A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent. got7fsn_ti cyclin-dependent protein kinase 5 holoenzyme complex cellular_component owl:Class
GO:1902554 biolink:NamedThing serine/threonine protein kinase complex A protein complex which is capable of protein serine/threonine kinase activity. got7fsn_ti PDR16 complex homodimer|PDR16 complex dimer An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay). bhm 2013-12-06T16:06:12Z cellular_component owl:Class
GO:0010464 biolink:NamedThing regulation of mesenchymal cell proliferation Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. got7fsn_ti biological_process owl:Class
GO:0042127 biolink:NamedThing regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation. got7fsn_ti regulation of cell proliferation biological_process owl:Class
GO:0051728 biolink:NamedThing cell cycle switching, mitotic to meiotic cell cycle The process in which a cell switches cell cycle mode from mitotic to meiotic division. got7fsn_ti conversion to meiosis|initiation of meiosis|initiation of meiotic cell cycle|entry into meiosis|conversion to meiotic cell cycle|cell cycle switching, mitosis to meiosis|meiotic entry|entry into meiotic cell cycle GO:0042061 biological_process owl:Class
GO:0060184 biolink:NamedThing cell cycle switching The process in which a cell switches cell cycle mode. got7fsn_ti biological_process owl:Class
GO:0033699 biolink:NamedThing DNA 5'-adenosine monophosphate hydrolase activity Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus. got7fsn_ti DNA adenylate hydrolysis activity|DNA de-adenylation|DNA 5'-adenylate hydrolase activity|DNA deadenylation|AMP-removal activity molecular_function owl:Class
GO:0035312 biolink:NamedThing 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. got7fsn_ti molecular_function owl:Class
GO:0003096 biolink:NamedThing renal sodium ion transport The directed movement of sodium ions (Na+) by the renal system. got7fsn_ti biological_process owl:Class
GO:0003014 biolink:NamedThing renal system process A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila). got7fsn_ti excretory system process|kidney system process biological_process owl:Class
GO:0018265 biolink:NamedThing GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine|GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine RESID:AA0158 biological_process owl:Class
GO:0021549 biolink:NamedThing cerebellum development The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. got7fsn_ti biological_process owl:Class
GO:0000109 biolink:NamedThing nucleotide-excision repair complex Any complex formed of proteins that act in nucleotide-excision repair. got7fsn_ti UvrBC complex|UvrB-UvrC complex Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. cellular_component owl:Class
GO:0002469 biolink:NamedThing myeloid dendritic cell antigen processing and presentation The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti biological_process owl:Class
GO:0006179 biolink:NamedThing guanosine salvage Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis. got7fsn_ti guanine, xanthine and their nucleoside salvage biological_process owl:Class
GO:0006166 biolink:NamedThing purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. got7fsn_ti MetaCyc:P121-PWY biological_process owl:Class
GO:0048875 biolink:NamedThing chemical homeostasis within a tissue Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue. got7fsn_ti biological_process owl:Class
GO:0038191 biolink:NamedThing neuropilin binding Binding to a member of the neuropilin family. got7fsn_ti Nrp binding|Nrp ligand|neuropilin-binding bf 2013-08-01T16:11:33Z molecular_function owl:Class
GO:0061246 biolink:NamedThing establishment or maintenance of bipolar cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns that regulates the shaping of a cell. got7fsn_ti dph 2010-08-23T09:46:01Z biological_process owl:Class
GO:0071963 biolink:NamedThing establishment or maintenance of cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell. got7fsn_ti mah 2011-06-21T03:47:21Z biological_process owl:Class
GO:0098992 biolink:NamedThing neuronal dense core vesicle A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. got7fsn_ti cellular_component owl:Class
GO:0031045 biolink:NamedThing dense core granule Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted. got7fsn_ti dense core vesicle NIF_Subcellular:sao772007592 cellular_component owl:Class
GO:0070980 biolink:NamedThing biphenyl catabolic process The chemical reactions and pathways resulting in the breakdown of biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs). got7fsn_ti biphenyl breakdown|biphenyl degradation|biphenyl catabolism mah 2009-10-27T11:24:59Z biological_process owl:Class
GO:1990397 biolink:NamedThing queuosine salvage Any process which produces queuosine from derivatives of it, without de novo synthesis. got7fsn_ti pr 2014-06-10T14:56:12Z biological_process owl:Class
GO:0008616 biolink:NamedThing queuosine biosynthetic process The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. got7fsn_ti queuosine biosynthesis|queuosine formation|queuosine synthesis|queuosine anabolism biological_process owl:Class
GO:0046555 biolink:NamedThing acetylxylan esterase activity Catalysis of the deacetylation of xylans and xylo-oligosaccharides. got7fsn_ti MetaCyc:3.1.1.72-RXN|EC:3.1.1.72 molecular_function owl:Class
GO:0071091 biolink:NamedThing alpha1-beta1 integrin-tissue transglutaminase complex A protein complex that consists of an alpha1-beta1 integrin complex bound to tissue transglutaminase. got7fsn_ti ITGA1-ITGB1-TGM2 complex mah 2009-11-06T04:46:44Z cellular_component owl:Class
GO:0036334 biolink:NamedThing epidermal stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells. got7fsn_ti bf 2012-09-05T10:21:23Z biological_process owl:Class
GO:0005979 biolink:NamedThing regulation of glycogen biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. got7fsn_ti regulation of glycogen synthesis|regulation of glycogen anabolism|regulation of glycogen formation|regulation of glycogen biosynthesis biological_process owl:Class
GO:0070873 biolink:NamedThing regulation of glycogen metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glycogen. got7fsn_ti regulation of glycogen metabolism mah 2009-08-20T02:44:53Z biological_process owl:Class
GO:0036120 biolink:NamedThing cellular response to platelet-derived growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. got7fsn_ti cellular response to PDGF stimulus bf 2012-02-20T02:49:02Z biological_process owl:Class
GO:0106307 biolink:NamedThing protein threonine phosphatase activity Catalysis of the reaction: protein threonine phosphate + H2O = protein threonine + phosphate. got7fsn_ti hjd 2020-09-09T19:38:50Z RHEA:47004|EC:3.1.3.16 molecular_function owl:Class
GO:0004722 biolink:NamedThing protein serine/threonine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. got7fsn_ti protein phosphatase type 4 activity|phosphatase II|protein phosphatase type 4, intrinsic catalyst activity|protein phosphatase type 2B activity|phosphatase SP|protein phosphatase type 1, intrinsic catalyst activity|protein D phosphatase|phosphatase I|calcineurin|magnesium-dependent protein serine/threonine phosphatase activity|protein phosphatase type 2C activity|serine/threonine specific protein phosphatase activity|phosphopyruvate dehydrogenase phosphatase|phosphospectrin phosphatase|phosphatase 2A|phosphatase H-II|phosphatase 2B|phosphatase IB|protein phosphatase type 2A activity|phosphatase C-II|BCKDH phosphatase|Aspergillus awamori acid protein phosphatase|protein phosphatase type 1 activity|phosphatase III|phosphatase IV|protein phosphatase type 2B, intrinsic catalyst activity|3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase|HMG-CoA reductase phosphatase|protein phosphatase X|polycation modulated (PCM-) phosphatase|casein phosphatase|branched-chain alpha-keto acid dehydrogenase phosphatase|protein phosphatase type 2A, intrinsic catalyst activity GO:0000158|GO:0030361|GO:0030357|GO:0030358|GO:0008598|GO:0008600|GO:0000163|GO:0004724|GO:0015071|GO:0030360 Reactome:R-HSA-3002811|Reactome:R-HSA-201790|Reactome:R-HSA-5692754|Reactome:R-HSA-199959|Reactome:R-HSA-5694421|Reactome:R-HSA-209055|Reactome:R-HSA-9660538|Reactome:R-HSA-163568|Reactome:R-HSA-9619449|Reactome:R-HSA-2187401|Reactome:R-HSA-6792863|Reactome:R-HSA-4419948|Reactome:R-HSA-5672961|Reactome:R-HSA-429730|Reactome:R-HSA-1638821|Reactome:R-HSA-5675431|Reactome:R-HSA-3601585|Reactome:R-HSA-2995388|Reactome:R-HSA-1295632|Reactome:R-HSA-74948|Reactome:R-HSA-9619467|Reactome:R-HSA-201787|EC:3.1.3.16|Reactome:R-HSA-5683405|Reactome:R-HSA-5693153|Reactome:R-HSA-8948139|Reactome:R-HSA-9619430|Reactome:R-HSA-9660536|Reactome:R-HSA-199425|Reactome:R-HSA-5687758|Reactome:R-HSA-5679206|Reactome:R-HSA-4088141|Reactome:R-HSA-5675433|Reactome:R-HSA-5672957|Reactome:R-HSA-9686524|Reactome:R-HSA-6811504|Reactome:R-HSA-9658445|Reactome:R-HSA-380949 molecular_function owl:Class
GO:0030743 biolink:NamedThing rRNA (adenosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine. got7fsn_ti rRNA adenosine 2'-methylase activity|ribosomal ribonucleate adenosine 2'-methyltransferase activity|RNA-pentose methylase activity|S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity|thiostrepton-resistance methylase activity MetaCyc:2.1.1.66-RXN|RHEA:43212|EC:2.1.1.230 molecular_function owl:Class
GO:0016433 biolink:NamedThing rRNA (adenine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. got7fsn_ti molecular_function owl:Class
GO:0031230 biolink:NamedThing intrinsic component of cell outer membrane The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to cell outer membrane cellular_component owl:Class
GO:0031224 biolink:NamedThing intrinsic component of membrane The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane. got7fsn_ti intrinsic to membrane Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. cellular_component owl:Class
GO:0097155 biolink:NamedThing fasciculation of sensory neuron axon The collection of sensory neuron axons into a bundle of rods, known as a fascicle. got7fsn_ti pr 2011-09-16T09:17:34Z biological_process owl:Class
GO:0007413 biolink:NamedThing axonal fasciculation The collection of axons into a bundle of rods, known as a fascicle. got7fsn_ti fasciculation of neuron biological_process owl:Class
GO:0018345 biolink:NamedThing protein palmitoylation The covalent attachment of a palmitoyl group to a protein. got7fsn_ti protein amino acid palmitoylation GO:0018349|GO:0018318 biological_process owl:Class
GO:0005871 biolink:NamedThing kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. got7fsn_ti cellular_component owl:Class
GO:0005875 biolink:NamedThing microtubule associated complex Any multimeric complex connected to a microtubule. got7fsn_ti cellular_component owl:Class
GO:0050962 biolink:NamedThing detection of light stimulus involved in sensory perception The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light. got7fsn_ti sensory perception, sensory detection of light stimulus|sensory transduction of light stimulus during sensory perception|sensory transduction of light stimulus|sensory detection of light stimulus|sensory perception, sensory transduction of light stimulus|sensory detection of light stimulus during sensory perception biological_process owl:Class
GO:0052672 biolink:NamedThing CTP:geranylgeraniol kinase activity Catalysis of the reaction: geranylgeraniol + CTP = all-trans-geranyl-geranyl monophosphate + CDP. got7fsn_ti CTP:geranylgeraniol phosphotransferase activity ai 2011-04-11T03:26:04Z EC:2.7.1.216|MetaCyc:RXN-11629 molecular_function owl:Class
GO:0052671 biolink:NamedThing geranylgeraniol kinase activity Catalysis of the reaction: geranylgeraniol + nucleoside triphosphate = all-trans-geranyl-geranyl monophosphate + nucleoside diphosphate. got7fsn_ti geranylgeraniol phosphotransferase activity ai 2011-04-11T03:18:44Z molecular_function owl:Class
GO:0043438 biolink:NamedThing acetoacetic acid metabolic process The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH. got7fsn_ti 3-oxobutanoic acid metabolic process|beta-ketobutyric acid metabolic process|beta ketobutyric acid metabolism|beta ketobutyric acid metabolic process|beta-ketobutyric acid metabolism|acetoacetate metabolism|acetoacetate metabolic process|3-oxobutanoate metabolic process|diacetic acid metabolic process|diacetic acid metabolism|3-oxobutanoate metabolism|acetoacetic acid metabolism|3-oxobutanoic acid metabolism biological_process owl:Class
GO:0046459 biolink:NamedThing short-chain fatty acid metabolic process The chemical reactions and pathways involving fatty acids with a chain length of less than C6. got7fsn_ti short-chain fatty acid metabolism biological_process owl:Class
GO:0018767 biolink:NamedThing 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate. got7fsn_ti UM-BBD_reactionID:r0399 molecular_function owl:Class
GO:0016823 biolink:NamedThing hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group. got7fsn_ti EC:3.7.1.- molecular_function owl:Class
GO:0060143 biolink:NamedThing positive regulation of syncytium formation by plasma membrane fusion Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. got7fsn_ti biological_process owl:Class
GO:0051130 biolink:NamedThing positive regulation of cellular component organization Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. got7fsn_ti upregulation of cell organization|stimulation of cell organization|up-regulation of cell organization|up regulation of cell organization|positive regulation of cell organisation|activation of cell organization|positive regulation of cellular component organization and biogenesis biological_process owl:Class
GO:0033514 biolink:NamedThing L-lysine catabolic process to acetyl-CoA via L-pipecolate The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate L-pipecolate. got7fsn_ti L-lysine breakdown to acetyl-CoA via L-pipecolate|L-lysine degradation to acetyl-CoA via L-pipecolate MetaCyc:PWY-5283 biological_process owl:Class
GO:0019474 biolink:NamedThing L-lysine catabolic process to acetyl-CoA The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA. got7fsn_ti L-lysine degradation to acetyl-CoA|L-lysine breakdown to acetyl-CoA biological_process owl:Class
GO:0106296 biolink:NamedThing D-series resolvin biosynthetic process The chemical reactions and pathways resulting in the formation of resolvin family D-series, hydroxy fatty acids derived from docosahexaenoic acid. got7fsn_ti hjd 2020-08-25T13:48:32Z biological_process owl:Class
GO:0106295 biolink:NamedThing resolvin biosynthetic process The chemical reactions and pathways resulting in the formation of resolvins, di- or trihydroxy fatty acids derived from omega-3 polyunsaturated fatty acids, specifically icosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid. got7fsn_ti Resolvin biosynthesis is a combination of oxidation, reduction and hydrolysis reactions involving lipoxygenases and cyclooxygenases. hjd 2020-08-25T13:46:15Z biological_process owl:Class
GO:0004151 biolink:NamedThing dihydroorotase activity Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+). got7fsn_ti carbamoylaspartic dehydrase activity|dihydroorotate hydrolase activity|(S)-dihydroorotate amidohydrolase activity|DHOase activity MetaCyc:DIHYDROOROT-RXN|RHEA:24296|EC:3.5.2.3|KEGG_REACTION:R01993|Reactome:R-HSA-73571 molecular_function owl:Class
GO:0016812 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. got7fsn_ti Reactome:R-HSA-70906|EC:3.5.2.- molecular_function owl:Class
GO:0044594 biolink:NamedThing 17-beta-hydroxysteroid dehydrogenase (NAD+) activity Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+. got7fsn_ti jl 2012-04-26T04:49:13Z RHEA:24612 molecular_function owl:Class
GO:0004303 biolink:NamedThing estradiol 17-beta-dehydrogenase activity Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. got7fsn_ti 20alpha-hydroxysteroid dehydrogenase|estradiol dehydrogenase activity|17beta,20alpha-hydroxysteroid dehydrogenase activity|estradiol-17beta:NAD(P)+ 17-oxidoreductase activity|17beta-hydroxysteroid dehydrogenase activity|17-beta-hydroxysteroid dehydrogenase activity|estrogen 17-oxidoreductase activity|17-beta-HSD activity|17-beta-estradiol dehydrogenase activity|estradiol 17beta-dehydrogenase activity|17beta-HSD|17beta-estradiol dehydrogenase activity Reactome:R-HSA-804969|Reactome:R-HSA-5693390|Reactome:R-HSA-6810594|EC:1.1.1.62|Reactome:R-HSA-8862137|Reactome:R-HSA-5696822|MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0002015 biolink:NamedThing regulation of systemic arterial blood pressure by atrial baroreceptor feedback A process that controls blood pressure by sensing the amount of stretch occurring in the atria. got7fsn_ti atrial control of blood pressure|atrial reflex|atrial baroreceptor regulation of systemic arterial blood pressure|atrial low pressure baroreceptor regulation of blood pressure biological_process owl:Class
GO:0003015 biolink:NamedThing heart process A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. got7fsn_ti cardiac process biological_process owl:Class
GO:0031077 biolink:NamedThing post-embryonic camera-type eye development The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. got7fsn_ti post-embryonic camera-style eye development biological_process owl:Class
GO:0047324 biolink:NamedThing phosphoenolpyruvate-glycerone phosphotransferase activity Catalysis of the reaction: glycerone + phosphoenolpyruvate = glycerone phosphate + pyruvate. got7fsn_ti phosphoenolpyruvate:glycerone phosphotransferase activity KEGG_REACTION:R01012|MetaCyc:2.7.1.121-RXN|RHEA:18381|EC:2.7.1.121 molecular_function owl:Class
GO:0014886 biolink:NamedThing transition between slow and fast fiber The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. got7fsn_ti transition slow-fast fibre|transition between slow and fast fibre|transition slow-fast fiber biological_process owl:Class
GO:0014733 biolink:NamedThing regulation of skeletal muscle adaptation Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. got7fsn_ti regulation of skeletal muscle plasticity biological_process owl:Class
GO:0048316 biolink:NamedThing seed development The process whose specific outcome is the progression of the seed over time, from its formation to the mature structure. A seed is a propagating organ formed in the sexual reproductive cycle of gymnosperms and angiosperms, consisting of a protective coat enclosing an embryo and food reserves. got7fsn_ti biological_process owl:Class
GO:0007414 biolink:NamedThing axonal defasciculation Separation of axons away from a bundle of axons known as a fascicle. got7fsn_ti defasciculation of neuron biological_process owl:Class
GO:0008038 biolink:NamedThing neuron recognition The process in which a neuronal cell in a multicellular organism interprets its surroundings. got7fsn_ti neuronal cell recognition biological_process owl:Class
GO:0035488 biolink:NamedThing cytosine/thymine mispair binding Binding to a double-stranded DNA region containing a C/T mispair. got7fsn_ti C/T mispair binding|thymine/cytosine mispair binding|T/C mispair binding bf 2010-04-23T10:57:13Z molecular_function owl:Class
GO:0030983 biolink:NamedThing mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches. got7fsn_ti mispair binding|mispaired DNA binding GO:0032134 molecular_function owl:Class
GO:0045736 biolink:NamedThing negative regulation of cyclin-dependent protein serine/threonine kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. got7fsn_ti biological_process owl:Class
GO:0045786 biolink:NamedThing negative regulation of cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. got7fsn_ti negative regulation of progression through cell cycle|downregulation of progression through cell cycle|inhibition of progression through cell cycle|negative regulation of cell cycle progression|down-regulation of progression through cell cycle|down regulation of progression through cell cycle biological_process owl:Class
GO:0034727 biolink:NamedThing piecemeal microautophagy of the nucleus Degradation of a cell nucleus by lysosomal microautophagy. got7fsn_ti PMN biological_process owl:Class
GO:0016237 biolink:NamedThing lysosomal microautophagy The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment. got7fsn_ti biological_process owl:Class
GO:0061276 biolink:NamedThing mesonephric proximal tubule morphogenesis The process in which the anatomical structures of a mesonephric proximal tubule are generated and organized. The mesonephric proximal tubule extends from the capsule to the distal tubule. got7fsn_ti dph 2010-09-02T01:11:02Z biological_process owl:Class
GO:0061240 biolink:NamedThing mesonephric nephron tubule morphogenesis The process in which the anatomical structures of a mesonephric nephron tubule are generated and organized. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros. got7fsn_ti dph 2010-08-19T03:09:26Z biological_process owl:Class
GO:0003087 biolink:NamedThing positive regulation of the force of heart contraction by neuronal epinephrine The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction. got7fsn_ti increased force of heart contraction by neuronal epinephrine|increased force of heart contraction by epinephrine released from the nerve endings|positive regulation of heart contraction by neuronal epinephrine|positive regulation of heart contraction by adrenaline|increased force of heart contraction by neuronal adrenaline biological_process owl:Class
GO:0003059 biolink:NamedThing positive regulation of the force of heart contraction by epinephrine The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction. got7fsn_ti adrenaline cardiac inotropy|epinephrine cardiac inotropy|adrenaline regulation of the strength of heart muscle contraction|positive regulation of heart contraction by adrenaline|increased force of heart contraction by epinephrine|positive regulation of heart contraction by epinephrine biological_process owl:Class
GO:0015668 biolink:NamedThing type III site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites. got7fsn_ti type III restriction enzyme activity EC:3.1.21.5|MetaCyc:3.1.21.5-RXN molecular_function owl:Class
GO:0016888 biolink:NamedThing endodeoxyribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. got7fsn_ti endodeoxyribonuclease activity, producing 5' phosphomonoesters EC:3.1.21.-|Reactome:R-HSA-912368 molecular_function owl:Class
GO:0021888 biolink:NamedThing hypothalamus gonadotrophin-releasing hormone neuron development The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell. got7fsn_ti hypothalamus gonadotropin-releasing hormone neuron development biological_process owl:Class
GO:0021884 biolink:NamedThing forebrain neuron development The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0033958 biolink:NamedThing DNA-deoxyinosine glycosylase activity Catalysis of the hydrolysis of DNA and polynucleotides, releasing free hypoxanthine. got7fsn_ti deoxyribonucleic acid glycosylase activity|hypoxanthine-DNA glycosylase activity|DNA-deoxyinosine deoxyribohydrolase activity|DNA-deoxyinosine glycosidase activity|DNA(hypoxanthine) glycohydrolase activity EC:3.2.2.15|MetaCyc:3.2.2.15-RXN molecular_function owl:Class
GO:1990324 biolink:NamedThing collagen type XXVI trimer A collagen homotrimer of alpha1(XXVI) chains. got7fsn_ti bhm 2014-03-16T23:02:35Z cellular_component owl:Class
GO:0001410 biolink:NamedThing chlamydospore formation The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans. got7fsn_ti chlamydospore development GO:0055027 biological_process owl:Class
GO:0048468 biolink:NamedThing cell development The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti terminal differentiation biological_process owl:Class
GO:0031418 biolink:NamedThing L-ascorbic acid binding Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. got7fsn_ti L-ascorbate binding|vitamin C binding molecular_function owl:Class
GO:0019842 biolink:NamedThing vitamin binding Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti molecular_function owl:Class
GO:0043637 biolink:NamedThing puromycin metabolic process The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger. got7fsn_ti puromycin metabolism biological_process owl:Class
GO:0016999 biolink:NamedThing antibiotic metabolic process The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. got7fsn_ti antibiotic metabolism biological_process owl:Class
GO:1990374 biolink:NamedThing Kir2 inward rectifier potassium channel complex A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells. got7fsn_ti Kir2.1 complex An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay). bhm 2014-04-25T15:29:15Z cellular_component owl:Class
GO:1902937 biolink:NamedThing inward rectifier potassium channel complex A protein complex which is capable of inward rectifier potassium channel activity. got7fsn_ti An example of this is Kcnj2 in mouse (P35561) in PMID:16834334 (inferred from direct assay). bhm 2014-04-25T15:18:41Z cellular_component owl:Class
GO:0060693 biolink:NamedThing regulation of branching involved in salivary gland morphogenesis Any process that modulates the rate, frequency, or extent of branching morphogenesis in the salivary gland epithelium. got7fsn_ti dph 2009-06-08T01:14:44Z biological_process owl:Class
GO:2000027 biolink:NamedThing regulation of animal organ morphogenesis Any process that modulates the frequency, rate or extent of animal organ morphogenesis. got7fsn_ti regulation of histogenesis and organogenesis tb 2010-08-05T11:26:27Z biological_process owl:Class
GO:0050681 biolink:NamedThing androgen receptor binding Binding to an androgen receptor. got7fsn_ti AR binding molecular_function owl:Class
GO:0007075 biolink:NamedThing positive regulation of transcription involved in exit from mitosis, from RNA polymerase III promoter Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. got7fsn_ti activation of transcription on exit from mitosis, from RNA polymerase III promoter|activation of transcription on exit from mitosis, from Pol III promoter biological_process owl:Class
GO:0044470 biolink:NamedThing envenomation resulting in negative regulation of blood coagulation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism. got7fsn_ti jl 2012-01-19T01:32:48Z biological_process owl:Class
GO:0044483 biolink:NamedThing envenomation resulting in impairment of hemostasis in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism. got7fsn_ti envenomation, impairing hemostasis in other organism|envenomation resulting in negative regulation of hemostasis in other organism jl 2012-01-19T03:15:56Z biological_process owl:Class
GO:0052495 biolink:NamedThing occlusion by organism of vascular system in other organism involved in symbiotic interaction The process in which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction. got7fsn_ti occlusion by organism of vascular system in other organism during symbiotic interaction biological_process owl:Class
GO:0052185 biolink:NamedThing modification of structure of other organism involved in symbiotic interaction The process in which an organism effects a change in an anatomical part or cellular component of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modification of structure of other organism during symbiotic interaction biological_process owl:Class
GO:0046523 biolink:NamedThing S-methyl-5-thioribose-1-phosphate isomerase activity Catalysis of the reaction: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. got7fsn_ti MTR-1-P isomerase activity|5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity|1-phospho-5'-S-methylthioribose isomerase activity|S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase activity|S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase activity|1-PMTR isomerase activity|S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase activity|S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate aldose-ketose-isomerase activity|methylthioribose 1-phosphate isomerase activity|5-methylthioribose-1-phosphate isomerase activity MetaCyc:5.3.1.23-RXN|Reactome:R-HSA-1299507|Reactome:R-HSA-1237096|RHEA:19989|EC:5.3.1.23|KEGG_REACTION:R04420 molecular_function owl:Class
GO:0102608 biolink:NamedThing tetracenomycin B3 8-O-methyl transferase activity Catalysis of the reaction: tetracenomycin B3 + S-adenosyl-L-methionine <=> tetracenomycin E + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-15435 molecular_function owl:Class
GO:0070341 biolink:NamedThing fat cell proliferation The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat. got7fsn_ti adipocyte proliferation|adipose cell proliferation biological_process owl:Class
GO:0045924 biolink:NamedThing regulation of female receptivity Any process that modulates the frequency, rate or extent of the willingness or readiness of a female to receive male advances. got7fsn_ti female receptivity GO:0060181 biological_process owl:Class
GO:0060180 biolink:NamedThing female mating behavior The specific behavior of a female organism that is associated with reproduction. got7fsn_ti biological_process owl:Class
GO:0097697 biolink:NamedThing tRNA 5-carboxymethoxyuridine methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule. got7fsn_ti pr 2016-01-07T10:36:46Z molecular_function owl:Class
GO:0016300 biolink:NamedThing tRNA (uracil) methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. got7fsn_ti tRNA (uridine) methyltransferase activity Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). GO:0016431 molecular_function owl:Class
GO:0098509 biolink:NamedThing sensory perception of humidity The series of events required for an organism to detect some level of humidity in its environment, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti hygrosensory perception Note, this is not classified under 'detection of chemical stimulus' as there are various potential mechanisms of hygroperception including detection of mechanical stimulus. dos 2013-09-25T13:52:27Z biological_process owl:Class
GO:0008656 biolink:NamedThing cysteine-type endopeptidase activator activity involved in apoptotic process Binds to and increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process. got7fsn_ti caspase activator activity Examples of this are 1) granzymes that may bind to initiator caspases and cleave them, and 2) already active caspases, e.g. caspase 9, that cleave effector caspases. Reactome:R-HSA-449073|Reactome:R-HSA-205117 molecular_function owl:Class
GO:0016505 biolink:NamedThing peptidase activator activity involved in apoptotic process Binds to and increases the activity of a peptidase that is involved in the apoptotic process. got7fsn_ti apoptotic protease activator activity molecular_function owl:Class
GO:0061226 biolink:NamedThing proximal/distal pattern formation involved in mesonephric nephron development The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the mesonephros. The proximal/distal axis is defined by a line that runs from the glomerulus (proximal end) outward toward the mesonephric duct (distal end). got7fsn_ti dph 2010-08-19T02:10:25Z biological_process owl:Class
GO:0072047 biolink:NamedThing proximal/distal pattern formation involved in nephron development The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end). got7fsn_ti proximal/distal nephron patterning|proximal-distal pattern formation involved in nephron development mah 2010-01-25T03:30:48Z biological_process owl:Class
GO:0090557 biolink:NamedThing establishment of endothelial intestinal barrier The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. got7fsn_ti tb 2013-10-29T15:08:27Z biological_process owl:Class
GO:0061028 biolink:NamedThing establishment of endothelial barrier The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. got7fsn_ti dph 2010-02-09T09:26:59Z biological_process owl:Class
GO:0047391 biolink:NamedThing alkylglycerophosphoethanolamine phosphodiesterase activity Catalysis of the reaction: H2O + 1-alkyl-sn-glycero-3-phosphoethanolamine = ethanolamine + 1-alkyl-sn-glycerol 3-phosphate. got7fsn_ti 1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase activity|lysophospholipase D activity EC:3.1.4.39|RHEA:15965|MetaCyc:3.1.4.39-RXN molecular_function owl:Class
GO:0086042 biolink:NamedThing cardiac muscle cell-cardiac muscle cell adhesion The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules. got7fsn_ti cardiomyocyte-cardiomyocyte adhesion tb 2011-11-11T04:06:25Z biological_process owl:Class
GO:0036093 biolink:NamedThing germ cell proliferation The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population. got7fsn_ti bf 2012-01-17T04:06:27Z biological_process owl:Class
GO:0022403 biolink:NamedThing cell cycle phase One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0080049 biolink:NamedThing L-gulono-1,4-lactone dehydrogenase activity Catalysis of the reaction: L-gulono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c. got7fsn_ti MetaCyc:RXN-1439 molecular_function owl:Class
GO:0016632 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome. got7fsn_ti EC:1.3.2.- molecular_function owl:Class
GO:0005215 biolink:NamedThing transporter activity Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. got7fsn_ti carrier Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. GO:0005478 Reactome:R-HSA-178215|Reactome:R-HSA-168313|EC:7.-.-.- molecular_function owl:Class
GO:0030034 biolink:NamedThing microvillar actin bundle assembly Assembly of the parallel bundle of actin filaments at the core of a microvillus. got7fsn_ti biological_process owl:Class
GO:0051017 biolink:NamedThing actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. got7fsn_ti actin cable formation|actin bundling activity|actin cable assembly GO:0045011 biological_process owl:Class
GO:0090447 biolink:NamedThing glycerol-3-phosphate 2-O-acyltransferase activity Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate. got7fsn_ti tb 2012-08-31T09:23:12Z molecular_function owl:Class
GO:0061581 biolink:NamedThing corneal epithelial cell migration The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism. got7fsn_ti dph 2013-12-23T07:28:29Z biological_process owl:Class
GO:0010631 biolink:NamedThing epithelial cell migration The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. got7fsn_ti biological_process owl:Class
GO:0090664 biolink:NamedThing response to high population density Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area. got7fsn_ti response to crowding tb 2015-10-21T16:00:30Z biological_process owl:Class
GO:0043794 biolink:NamedThing formate dehydrogenase (coenzyme F420) activity Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420. got7fsn_ti formate dehydrogenase (F420) activity EC:1.2.99.- molecular_function owl:Class
GO:0046877 biolink:NamedThing regulation of saliva secretion Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue. got7fsn_ti biological_process owl:Class
GO:0021503 biolink:NamedThing neural fold bending The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse. got7fsn_ti biological_process owl:Class
GO:0061288 biolink:NamedThing mesonephric capsule specification The regionalization process in which the identity of the mesonephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti dph 2010-09-02T01:56:20Z biological_process owl:Class
GO:0072130 biolink:NamedThing renal capsule specification The regionalization process in which the identity of the renal capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti mah 2010-02-22T02:12:34Z biological_process owl:Class
GO:0019197 biolink:NamedThing phosphoenolpyruvate-dependent sugar phosphotransferase complex Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system). got7fsn_ti cellular_component owl:Class
GO:0061088 biolink:NamedThing regulation of sequestering of zinc ion Any process that modulates the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. got7fsn_ti dph 2010-04-26T01:38:53Z biological_process owl:Class
GO:0034010 biolink:NamedThing sulfolactate sulfo-lyase activity Catalysis of the reaction: 3-sulfolactate = pyruvate + sulfite. got7fsn_ti 3-sulfolactate bisulfite-lyase activity|3-sulfolactate bisulfite-lyase (pyruvate-forming) activity|SuyAB|Suy KEGG_REACTION:R07633|EC:4.4.1.24|MetaCyc:4.4.1.24-RXN|RHEA:21428 molecular_function owl:Class
GO:0016846 biolink:NamedThing carbon-sulfur lyase activity Catalysis of the elimination of hydrogen sulfide or substituted H2S. got7fsn_ti carbon-sulphur lyase activity Reactome:R-HSA-1614567|EC:4.4.-.- molecular_function owl:Class
GO:0031247 biolink:NamedThing actin rod assembly The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules. got7fsn_ti actin rod formation biological_process owl:Class
GO:0007015 biolink:NamedThing actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. got7fsn_ti regulation of actin filament localization|actin filament organisation biological_process owl:Class
GO:0007107 biolink:NamedThing membrane addition at site of cytokinesis Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion. got7fsn_ti cytokinesis, membrane recruitment/generation biological_process owl:Class
GO:0061024 biolink:NamedThing membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. got7fsn_ti cellular membrane organisation|cellular membrane organization|single-organism membrane organization|membrane organisation|membrane organization and biogenesis jl 2010-02-08T02:43:11Z GO:0016044|GO:0044802 biological_process owl:Class
GO:0098564 biolink:NamedThing trans-Golgi network transport vesicle lumen The volume enclosed within the membrane of a trans-Golgi network transport vesicle. got7fsn_ti cellular_component owl:Class
GO:0098566 biolink:NamedThing transport vesicle lumen The volume enclosed within the membrane of a transport vesicle. got7fsn_ti cellular_component owl:Class
GO:0004483 biolink:NamedThing mRNA (nucleoside-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine. got7fsn_ti mRNA (adenosine-2'-O-)-methyltransferase activity|S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity|messenger RNA (nucleoside-2'-)-methyltransferase activity|messenger ribonucleate nucleoside 2'-methyltransferase activity Reactome:R-HSA-9694499|Reactome:R-HSA-9684033|Reactome:R-HSA-9694521|EC:2.1.1.57|Reactome:R-HSA-9694721|Reactome:R-HSA-9684032|Reactome:R-HSA-9684030|MetaCyc:2.1.1.57-RXN molecular_function owl:Class
GO:0008171 biolink:NamedThing O-methyltransferase activity Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. got7fsn_ti Reactome:R-HSA-5629218|Reactome:R-HSA-5578717|Reactome:R-HSA-5629237|Reactome:R-HSA-6790907|Reactome:R-HSA-5629203|EC:2.1.1.- molecular_function owl:Class
GO:0120116 biolink:NamedThing glucagon processing The formation of mature glucagon by proteolysis of the precursor proglucagon. got7fsn_ti krc 2017-11-08T19:31:42Z biological_process owl:Class
GO:0016486 biolink:NamedThing peptide hormone processing The generation of a mature peptide hormone by posttranslational processing of a prohormone. got7fsn_ti biological_process owl:Class
GO:0003868 biolink:NamedThing 4-hydroxyphenylpyruvate dioxygenase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. got7fsn_ti p-hydroxyphenylpyruvate oxidase activity|p-hydroxyphenylpyruvate dioxygenase activity|4-hydroxyphenylpyruvic acid dioxygenase activity|p-hydroxyphenylpyruvate hydroxylase activity|p-hydroxyphenylpyruvic hydroxylase activity|4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)|p-hydroxyphenylpyruvic acid hydroxylase activity|p-hydroxyphenylpyruvic oxidase activity|4-hydroxyphenylpyruvate hydroxylase activity Reactome:R-HSA-71163|EC:1.13.11.27|UM-BBD_reactionID:r0298|MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN|RHEA:16189 molecular_function owl:Class
GO:0034644 biolink:NamedThing cellular response to UV Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. got7fsn_ti cellular response to ultraviolet radiation stimulus|cellular response to UV radiation stimulus|cellular response to ultraviolet light stimulus|cellular response to UV light stimulus biological_process owl:Class
GO:0070338 biolink:NamedThing 5'-flap-structured DNA binding Binding to a 5'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 5'-end of DNA or RNA protrudes from a double-stranded DNA molecule. 5'-flap structures can be formed during DNA repair or lagging strand synthesis; in the latter case RNA flaps form from lagging strand RNA primers. got7fsn_ti molecular_function owl:Class
GO:0070336 biolink:NamedThing flap-structured DNA binding Binding to a flap structure in DNA. A DNA flap structure is one in which a single-stranded length of DNA or RNA protrudes from a double-stranded DNA molecule. got7fsn_ti molecular_function owl:Class
GO:0090567 biolink:NamedThing reproductive shoot system development The process whose specific outcome is the progression of a reproductive shoot system over time, from its formation to the mature structure. got7fsn_ti tb 2014-04-25T15:42:03Z biological_process owl:Class
GO:0034198 biolink:NamedThing cellular response to amino acid starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. got7fsn_ti general amino acid control response|GAAC response biological_process owl:Class
GO:1990928 biolink:NamedThing response to amino acid starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. got7fsn_ti sl 2016-02-18T00:18:23Z biological_process owl:Class
GO:0051290 biolink:NamedThing protein heterotetramerization The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical. got7fsn_ti protein heterotetramer assembly|protein heterotetramer formation|protein heterotetramer biosynthesis|protein heterotetramer biosynthetic process biological_process owl:Class
GO:0051262 biolink:NamedThing protein tetramerization The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. got7fsn_ti protein tetramer assembly|protein tetramer biosynthetic process|protein tetramer formation|protein tetramer biosynthesis biological_process owl:Class
GO:0060487 biolink:NamedThing lung epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung. got7fsn_ti pulmonary epithelial cell differentiation biological_process owl:Class
GO:0007589 biolink:NamedThing body fluid secretion The controlled release of a fluid by a cell or tissue in an animal. got7fsn_ti biological_process owl:Class
GO:0052624 biolink:NamedThing 2-phytyl-1,4-naphthoquinone methyltransferase activity Catalysis of the reaction: demethylphylloquinone + S-adenosyl-L-methionine = phylloquinone + S-adenosyl-L-homocysteine + H+. got7fsn_ti S-adenosyl-L-methionine:2-phytyl-1,4-naphthoquinone methyltransferase activity|salicylic acid methyltransferase activity|S-adenosyl-L-methionine:demethylphylloquinone methyltransferase activity|salicylate methyltransferase activity|S-adenosyl-L-methionine:salicylate carboxyl methyltransferase activity|demethylphylloquinone methyltransferase activity|SA methyltransferase activity ai 2010-08-26T12:00:06Z KEGG_REACTION:R06859|MetaCyc:RXN-6723|MetaCyc:RXN-7569 molecular_function owl:Class
GO:0090472 biolink:NamedThing dibasic protein processing Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein. got7fsn_ti tb 2012-10-01T10:39:26Z biological_process owl:Class
GO:0016485 biolink:NamedThing protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. got7fsn_ti protein maturation by peptide bond cleavage|peptidolysis during protein maturation|protein maturation by proteolysis|protein maturation by peptide bond hydrolysis GO:0051605 biological_process owl:Class
GO:0043825 biolink:NamedThing succinylornithine transaminase activity Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate. got7fsn_ti succinyl ornithine transaminase activity|AstC|N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity|N2-succinylornithine 5-aminotransferase activity|2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity|succinylornithine aminotransferase activity|N(2)-succinylornithine 5-aminotransferase activity|SOAT|succinyl-ornithine transaminase activity MetaCyc:SUCCORNTRANSAM-RXN|KEGG_REACTION:R04217|RHEA:16953|EC:2.6.1.81 molecular_function owl:Class
GO:0102298 biolink:NamedThing selenocystathione synthase activity Catalysis of the reaction: L-selenocysteine + O-phosphonato-L-homoserine = hydrogenphosphate + L-selenocystathionine. got7fsn_ti MetaCyc:RXN-12728 molecular_function owl:Class
GO:0003203 biolink:NamedThing endocardial cushion morphogenesis The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. got7fsn_ti dph 2009-10-08T01:43:22Z biological_process owl:Class
GO:0072132 biolink:NamedThing mesenchyme morphogenesis The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells. got7fsn_ti mah 2010-02-22T02:17:15Z biological_process owl:Class
GO:0035651 biolink:NamedThing AP-3 adaptor complex binding Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). got7fsn_ti bf 2011-01-25T10:59:36Z molecular_function owl:Class
GO:0044877 biolink:NamedThing protein-containing complex binding Binding to a macromolecular complex. got7fsn_ti macromolecular complex binding|protein complex binding jl 2014-12-16T11:38:58Z GO:0032403 molecular_function owl:Class
GO:0006781 biolink:NamedThing succinyl-CoA pathway The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX. got7fsn_ti biosynthesis of protoporphyrin IX via succinyl CoA|succinyl CoA pathway|biosynthetic process of protoporphyrin IX via succinyl-CoA|biosynthetic process of protoporphyrin IX via succinyl CoA|biosynthesis of protoporphyrin IX via succinyl-CoA biological_process owl:Class
GO:0006779 biolink:NamedThing porphyrin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. got7fsn_ti porphyrin synthesis|porphyrin biosynthesis|porphyrin anabolism|porphyrin biosynthetic process|porphyrin formation biological_process owl:Class
GO:0018799 biolink:NamedThing 4-hydroxybenzoate decarboxylase activity Catalysis of the reaction: 4-hydroxybenzoate + H(+) = CO(2) + phenol. got7fsn_ti p-hydroxybenzoate decarboxylase activity|4-hydroxybenzoate carboxy-lyase (phenol-forming)|4-hydroxybenzoate carboxy-lyase activity EC:4.1.1.61|MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN|RHEA:10876|KEGG_REACTION:R01238|UM-BBD_reactionID:r0159 molecular_function owl:Class
GO:0071032 biolink:NamedThing nuclear mRNA surveillance of mRNP export The set of processes involved in identifying and degrading incorrectly formed or aberrant nuclear mRNPs docked at the nuclear pore complex prior to export to the cytoplasm. got7fsn_ti nuclear mRNA quality control of mRNAs in aberrant mRNPs|nuclear mRNA catabolic process of mRNAs in aberrant mRNPs krc 2009-07-28T04:31:57Z biological_process owl:Class
GO:0071028 biolink:NamedThing nuclear mRNA surveillance The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nucleus. got7fsn_ti nuclear mRNA quality control|nuclear aberrant mRNA catabolic process krc 2009-07-28T04:14:29Z biological_process owl:Class
GO:0045503 biolink:NamedThing dynein light chain binding Binding to a light chain of the dynein complex. got7fsn_ti molecular_function owl:Class
GO:1990814 biolink:NamedThing DNA/DNA annealing activity An activity that faciliates the formation of a complementary double-stranded DNA molecule. got7fsn_ti DNA reannealing activity https://github.com/geneontology/go-ontology/issues/2161 vw 2015-07-29T12:35:03Z molecular_function owl:Class
GO:0140666 biolink:NamedThing annealing activity An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule. got7fsn_ti renaturation https://github.com/geneontology/go-ontology/issues/21614 pr 2014-06-13T10:18:43Z GO:0097617 molecular_function owl:Class
GO:0070199 biolink:NamedThing establishment of protein localization to chromosome The directed movement of a protein to a specific location on a chromosome. got7fsn_ti establishment of protein localisation to chromosome biological_process owl:Class
GO:0106331 biolink:NamedThing sialate 4-O-acetylesterase activity Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate. got7fsn_ti hjd 2020-09-30T19:40:24Z EC:3.1.1.53|RHEA:25564 molecular_function owl:Class
GO:0001681 biolink:NamedThing sialate O-acetylesterase activity Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. got7fsn_ti N-acyl-O-acetylneuraminate O-acetylhydrolase activity|N-acetylneuraminate acetyltransferase activity|sialate 9(4)-O-acetylesterase activity MetaCyc:SIALATE-O-ACETYLESTERASE-RXN|EC:3.1.1.53 molecular_function owl:Class
GO:0006595 biolink:NamedThing polyamine metabolic process The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. got7fsn_ti polyamine metabolism biological_process owl:Class
GO:0008294 biolink:NamedThing calcium- and calmodulin-responsive adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin. got7fsn_ti calcium/calmodulin-responsive adenylate cyclase activity|calcium- and calmodulin-responsive adenylyl cyclase activity Reactome:R-HSA-111930|Reactome:R-HSA-442715 molecular_function owl:Class
GO:0004016 biolink:NamedThing adenylate cyclase activity Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. got7fsn_ti adenylyl cyclase activity|cAMP generating peptide activity|ATP pyrophosphate-lyase activity|ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity|ATP diphosphate-lyase (cyclizing) activity|adenylylcyclase activity|adenyl cyclase activity|3',5'-cyclic AMP synthetase activity Reactome:R-HSA-5211224|Reactome:R-HSA-170676|MetaCyc:ADENYLATECYC-RXN|Reactome:R-HSA-392129|RHEA:15389|EC:4.6.1.1|Reactome:R-HSA-164377|Reactome:R-HSA-5610727|Reactome:R-HSA-381607 molecular_function owl:Class
GO:0102262 biolink:NamedThing tRNA-dihydrouridine16 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil16 in tRNA + NAD(P) <=> H+ + a uracil16 in tRNA + NAD(P)H. got7fsn_ti MetaCyc:RXN-12454 molecular_function owl:Class
GO:0017150 biolink:NamedThing tRNA dihydrouridine synthase activity Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. got7fsn_ti RHEA:23624|MetaCyc:RXN0-1281|Reactome:R-HSA-6782296 molecular_function owl:Class
GO:0002159 biolink:NamedThing desmosome assembly A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. got7fsn_ti Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. hjd 2010-02-09T10:46:30Z biological_process owl:Class
GO:0002934 biolink:NamedThing desmosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. got7fsn_ti hjd 2012-05-08T02:59:08Z biological_process owl:Class
GO:0032158 biolink:NamedThing septin band A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously. got7fsn_ti cellular_component owl:Class
GO:0001551 biolink:NamedThing ovarian follicle endowment Association of oocytes with supporting epithelial granulosa cells to form primordial follicles. got7fsn_ti biological_process owl:Class
GO:0019771 biolink:NamedThing high-affinity IgG receptor activity Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti high affinity Fc receptor activity|high affinity IgG receptor activity molecular_function owl:Class
GO:0019770 biolink:NamedThing IgG receptor activity Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0090360 biolink:NamedThing platelet-derived growth factor production The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. tb 2010-07-12T10:32:27Z biological_process owl:Class
GO:0018993 biolink:NamedThing somatic sex determination The determination of sex and sexual phenotypes in an organism's soma. got7fsn_ti biological_process owl:Class
GO:0007530 biolink:NamedThing sex determination Any process that establishes and transmits the specification of sexual status of an individual organism. got7fsn_ti Wikipedia:Sex-determination_system biological_process owl:Class
GO:0008050 biolink:NamedThing female courtship behavior The behavior of a female, for the purpose of attracting a sexual partner. got7fsn_ti female courtship behaviour biological_process owl:Class
GO:0002357 biolink:NamedThing defense response to tumor cell Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism. got7fsn_ti biological_process owl:Class
GO:0002347 biolink:NamedThing response to tumor cell Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. got7fsn_ti biological_process owl:Class
GO:0050321 biolink:NamedThing tau-protein kinase activity Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. got7fsn_ti ATP:tau-protein O-phosphotransferase activity|tau-tubulin kinase activity|tau-protein kinase I activity|protein tau kinase activity|[Tau protein] kinase activity|tau-protein kinase II activity|tau kinase activity|cdk5/p20|TPK II|brain protein kinase PK40erk activity|TPK I|glycogen synthase kinase-3beta activity|TTK|tau protein kinase activity|CDK5/p23|STK31|TPK|GSK EC:2.7.11.26|MetaCyc:TAU-PROTEIN-KINASE-RXN molecular_function owl:Class
GO:0045619 biolink:NamedThing regulation of lymphocyte differentiation Any process that modulates the frequency, rate or extent of lymphocyte differentiation. got7fsn_ti regulation of lymphocyte development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0099519 biolink:NamedThing dense core granule cytoskeletal transport The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments. got7fsn_ti dense core granule cytoskeletal transport|dense core vesicle cytoskeletal trafficking biological_process owl:Class
GO:1901950 biolink:NamedThing dense core granule transport The directed movement a dense core granule within a cell. got7fsn_ti dense core vesicle transport goslim_synapse pr 2013-02-19T13:00:52Z biological_process owl:Class
GO:0071008 biolink:NamedThing U2-type post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs. got7fsn_ti GT-AG post-mRNA release spliceosomal complex|mammalian U2-type spliceosomal complex I|U2/U5/U6 snRNP complex|major post-mRNA release spliceosomal complex|U2/U5/U6 tri-snRNP complex mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0071014 biolink:NamedThing post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5. got7fsn_ti mammalian spliceosomal complex I mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0030312 biolink:NamedThing external encapsulating structure A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space. got7fsn_ti The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. cellular_component owl:Class
GO:0031266 biolink:NamedThing TRAIL death-inducing signaling complex A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor. got7fsn_ti TRAIL DISC|TRAIL death-inducing signalling complex cellular_component owl:Class
GO:0031264 biolink:NamedThing death-inducing signaling complex A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. got7fsn_ti DISC|death receptor-induced signalling complex|death receptor-induced signaling complex|DISC protein complex|death-inducing signalling complex Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Wikipedia:Death-inducing_signaling_complex cellular_component owl:Class
GO:0005828 biolink:NamedThing kinetochore microtubule Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. got7fsn_ti pole-to-kinetochore microtubule cellular_component owl:Class
GO:0005876 biolink:NamedThing spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole. got7fsn_ti cellular_component owl:Class
GO:0009861 biolink:NamedThing jasmonic acid and ethylene-dependent systemic resistance The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen. got7fsn_ti jasmonic acid/ethylene-dependent systemic resistance|jasmonic acid and ethene-dependent systemic resistance biological_process owl:Class
GO:0009611 biolink:NamedThing response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. got7fsn_ti physiological response to wounding GO:0002245 biological_process owl:Class
GO:1902187 biolink:NamedThing negative regulation of viral release from host cell Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell. got7fsn_ti down-regulation of viral shedding|downregulation of viral exit|down-regulation of viral exit|inhibition of viral release from host cell|down regulation of release of virus from host|negative regulation of release of virus from host|negative regulation of viral shedding|negative regulation of viral release|down regulation of viral shedding|negative regulation of viral exit|downregulation of release of virus from host|down regulation of viral release|down regulation of viral exit|inhibition of viral exit|down-regulation of release of virus from host|down-regulation of viral release|down regulation of viral release from host cell|downregulation of viral shedding|down-regulation of viral release from host cell|inhibition of viral release|downregulation of viral release from host cell|inhibition of viral shedding|inhibition of release of virus from host|downregulation of viral release ss 2013-06-04T03:54:08Z biological_process owl:Class
GO:0008889 biolink:NamedThing glycerophosphodiester phosphodiesterase activity Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. got7fsn_ti IgD-binding protein D|glycerophosphoryl diester phosphodiesterase activity|gene hpd protein|glycerophosphodiester glycerophosphohydrolase activity RHEA:12969|Reactome:R-HSA-1483116|EC:3.1.4.46|MetaCyc:GLYCPDIESTER-RXN|Reactome:R-HSA-1483107 molecular_function owl:Class
GO:0003232 biolink:NamedThing bulbus arteriosus development The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber. got7fsn_ti dph 2009-10-13T11:05:36Z biological_process owl:Class
GO:0003205 biolink:NamedThing cardiac chamber development The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart. got7fsn_ti dph 2009-10-13T09:11:18Z biological_process owl:Class
GO:0071253 biolink:NamedThing connexin binding Binding to a connexin, any of a group of related proteins that assemble to form gap junctions. got7fsn_ti mah 2009-12-04T10:07:54Z molecular_function owl:Class
GO:0030922 biolink:NamedThing peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues. got7fsn_ti RESID:AA0365 biological_process owl:Class
GO:0018251 biolink:NamedThing peptidyl-tyrosine dehydrogenation The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues. got7fsn_ti See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'. RESID:AA0183 biological_process owl:Class
GO:0051250 biolink:NamedThing negative regulation of lymphocyte activation Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. got7fsn_ti down-regulation of lymphocyte activation|down regulation of lymphocyte activation|downregulation of lymphocyte activation|inhibition of lymphocyte activation biological_process owl:Class
GO:0002695 biolink:NamedThing negative regulation of leukocyte activation Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation. got7fsn_ti negative regulation of immune cell activation|down regulation of leukocyte activation|downregulation of leukocyte activation|negative regulation of leucocyte activation|inhibition of leukocyte activation|down-regulation of leukocyte activation biological_process owl:Class
GO:2001158 biolink:NamedThing positive regulation of proline catabolic process to glutamate Any process that activates or increases the frequency, rate or extent of proline catabolic process to glutamate. got7fsn_ti positive regulation of proline degradation to glutamate|positive regulation of proline breakdown to glutamate|positive regulation of proline oxidation mcc 2011-10-25T08:54:50Z biological_process owl:Class
GO:0033243 biolink:NamedThing positive regulation of cellular amine catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. got7fsn_ti positive regulation of amine degradation|positive regulation of amine breakdown|positive regulation of amine catabolism biological_process owl:Class
GO:0048050 biolink:NamedThing post-embryonic eye morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight. got7fsn_ti GO:0048051 biological_process owl:Class
GO:0048592 biolink:NamedThing eye morphogenesis The process in which the anatomical structures of the eye are generated and organized. got7fsn_ti GO:0048748 biological_process owl:Class
GO:0005919 biolink:NamedThing pleated septate junction A septate junction in which regular arrays of electron-dense septae span the intermembrane space. got7fsn_ti pleated desmosome cellular_component owl:Class
GO:0005918 biolink:NamedThing septate junction A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods. got7fsn_ti septate desmosome NIF_Subcellular:sao427941916 cellular_component owl:Class
GO:0021797 biolink:NamedThing forebrain anterior/posterior pattern specification The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain. got7fsn_ti forebrain anterior-posterior pattern specification biological_process owl:Class
GO:0009952 biolink:NamedThing anterior/posterior pattern specification The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. got7fsn_ti anterior/posterior pattern formation biological_process owl:Class
GO:0008960 biolink:NamedThing phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose. got7fsn_ti phosphoglycerol transferase I|phosphoglycerol transferase activity|phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity|oligosaccharide glycerophosphotransferase activity MetaCyc:PGLYCEROLTRANSI-RXN|EC:2.7.8.20 molecular_function owl:Class
GO:0014843 biolink:NamedThing growth factor dependent regulation of skeletal muscle satellite cell proliferation Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. got7fsn_ti biological_process owl:Class
GO:0014842 biolink:NamedThing regulation of skeletal muscle satellite cell proliferation Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation. got7fsn_ti biological_process owl:Class
GO:0004064 biolink:NamedThing arylesterase activity Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. got7fsn_ti aryl-ester hydrolase|A-esterase activity|paraoxonase activity|aromatic esterase EC:3.1.1.2|UM-BBD_reactionID:r0757|MetaCyc:ARYLESTERASE-RXN|RHEA:17309 molecular_function owl:Class
GO:0021778 biolink:NamedThing oligodendrocyte cell fate specification The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0021780 biolink:NamedThing glial cell fate specification The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0031498 biolink:NamedThing chromatin disassembly The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA. got7fsn_ti chromatin maintenance biological_process owl:Class
GO:0006333 biolink:NamedThing chromatin assembly or disassembly The formation or destruction of chromatin structures. got7fsn_ti chromatin assembly/disassembly biological_process owl:Class
GO:0034508 biolink:NamedThing centromere complex assembly The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere. got7fsn_ti centromere assembly|chromosome, centromeric region assembly|centromere organization biological_process owl:Class
GO:0065004 biolink:NamedThing protein-DNA complex assembly The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex. got7fsn_ti DNA-protein complex assembly biological_process owl:Class
GO:0000249 biolink:NamedThing C-22 sterol desaturase activity Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. got7fsn_ti molecular_function owl:Class
GO:0070704 biolink:NamedThing sterol desaturase activity Catalysis of the introduction of a double bond into a sterol molecule. got7fsn_ti mah 2009-06-08T03:53:44Z molecular_function owl:Class
GO:0021903 biolink:NamedThing rostrocaudal neural tube patterning The process in which the neural tube is divided into specific regions along the rostrocaudal axis. got7fsn_ti anterior-posterior neural tube patterning biological_process owl:Class
GO:0003099 biolink:NamedThing positive regulation of the force of heart contraction by chemical signal Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. got7fsn_ti positive regulation of the force of heart muscle contraction by chemical signal biological_process owl:Class
GO:0003057 biolink:NamedThing regulation of the force of heart contraction by chemical signal The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. got7fsn_ti chemical cardiac inotropy|regulation of the force of heart muscle contraction by chemical signal biological_process owl:Class
GO:0071759 biolink:NamedThing IgX immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgX isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgX immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti Note that an IgX immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgX is found in amphibians. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0019814 biolink:NamedThing immunoglobulin complex A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti antibody Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. cellular_component owl:Class
GO:0004919 biolink:NamedThing interleukin-9 receptor activity Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-9R|IL-9 receptor activity molecular_function owl:Class
GO:0004896 biolink:NamedThing cytokine receptor activity Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL receptor|hematopoietin/interferon-class (D200-domain) cytokine receptor activity|interleukin receptor activity GO:0004907 molecular_function owl:Class
GO:0008023 biolink:NamedThing transcription elongation factor complex Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. got7fsn_ti cellular_component owl:Class
GO:0035794 biolink:NamedThing positive regulation of mitochondrial membrane permeability Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. got7fsn_ti mitochondrial membrane permeability transition|mitochondrial membrane permeabilization|positive regulation of transport across mitochondrial membrane|MPT|mitochondrial permeability transition bf 2011-04-11T01:44:06Z biological_process owl:Class
GO:1905710 biolink:NamedThing positive regulation of membrane permeability Any process that activates or increases the frequency, rate or extent of the passage or uptake of molecules by a membrane. got7fsn_ti hbye 2016-11-18T13:10:53Z biological_process owl:Class
GO:0016048 biolink:NamedThing detection of temperature stimulus The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal. got7fsn_ti perception of temperature|detection of temperature|detection of thermal stimulus biological_process owl:Class
GO:0009581 biolink:NamedThing detection of external stimulus The series of events in which an external stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of external stimulus biological_process owl:Class
GO:0034979 biolink:NamedThing NAD-dependent protein deacetylase activity Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD. got7fsn_ti Reactome:R-HSA-9667952|Reactome:R-HSA-5685953|Reactome:R-HSA-5688289|Reactome:R-HSA-9620532|Reactome:R-HSA-5211239|Reactome:R-HSA-5688294|Reactome:R-HSA-3371467 molecular_function owl:Class
GO:0033558 biolink:NamedThing protein deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate. got7fsn_ti Reactome:R-HSA-8952069|Reactome:R-HSA-9626962|Reactome:R-HSA-5693092 molecular_function owl:Class
GO:0070875 biolink:NamedThing positive regulation of glycogen metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glycogen. got7fsn_ti positive regulation of glycogen metabolism mah 2009-08-20T02:53:55Z biological_process owl:Class
GO:0010604 biolink:NamedThing positive regulation of macromolecule metabolic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biological_process owl:Class
GO:0002561 biolink:NamedThing basophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil. got7fsn_ti biological_process owl:Class
GO:0043299 biolink:NamedThing leukocyte degranulation The regulated exocytosis of secretory granules by a leukocyte. got7fsn_ti immune cell degranulation|immune cell granule exocytosis|leukocyte granule exocytosis|leucocyte degranulation biological_process owl:Class
GO:1990466 biolink:NamedThing protein autosumoylation The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. got7fsn_ti protein auto-sumoylation|protein self-sumoylation se 2014-08-25T22:37:21Z biological_process owl:Class
GO:0061108 biolink:NamedThing seminal vesicle epithelium development The progression of the seminal vesicle epithelium over time, from its formation to the mature structure. got7fsn_ti dph 2010-04-30T10:19:54Z biological_process owl:Class
GO:0098029 biolink:NamedThing icosahedral viral capsid, spike A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell. got7fsn_ti bm 2012-07-19T14:37:11Z cellular_component owl:Class
GO:0044423 biolink:NamedThing virion component Any constituent part of a virion, a complete fully infectious extracellular virus particle. got7fsn_ti virion part|virion|complete virus particle Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0019012 Wikipedia:Virus cellular_component owl:Class
GO:0060068 biolink:NamedThing vagina development The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0102338 biolink:NamedThing 3-oxo-lignoceronyl-CoA synthase activity Catalysis of the reaction: behenoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxotetracosanoyl-CoA. + carbon dioxide + coenzyme A. got7fsn_ti MetaCyc:RXN-13297|RHEA:36507 molecular_function owl:Class
GO:0006334 biolink:NamedThing nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. got7fsn_ti histone chaperone|nucleosome modeling biological_process owl:Class
GO:0042698 biolink:NamedThing ovulation cycle The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. got7fsn_ti biological_process owl:Class
GO:0048757 biolink:NamedThing pigment granule maturation Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state. got7fsn_ti biological_process owl:Class
GO:0003918 biolink:NamedThing DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. got7fsn_ti deoxyribonucleate topoisomerase|DNA topoisomerase II activity|DNA topoisomerase (ATP-hydrolysing)|DNA topoisomerase type II activity|DNA topoisomerase IV activity|deoxyribonucleic topoisomerase activity|topoisomerase II|topoisomerase|type II DNA topoisomerase activity|DNA topoisomerase II GO:0061505 EC:5.6.2.2|MetaCyc:5.99.1.3-RXN|Wikipedia:Type_II_topoisomerase molecular_function owl:Class
GO:0018717 biolink:NamedThing 9-phenanthrol glycosyltransferase activity Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O. got7fsn_ti UM-BBD_reactionID:r0511 molecular_function owl:Class
GO:0019112 biolink:NamedThing phenanthrol glycosyltransferase activity Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O. got7fsn_ti molecular_function owl:Class
GO:0033738 biolink:NamedThing methylenetetrahydrofolate reductase (ferredoxin) activity Catalysis of the reaction: 5-methyltetrahydrofolate + oxidized ferredoxin = 5,10-methylenetetrahydrofolate + reduced ferredoxin. got7fsn_ti 5-methyltetrahydrofolate:ferredoxin oxidoreductase activity|5,10-methylenetetrahydrofolate reductase activity RHEA:14229|EC:1.5.7.1|MetaCyc:RXN-5061 molecular_function owl:Class
GO:0033694 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. got7fsn_ti EC:1.5.7.- molecular_function owl:Class
GO:0047408 biolink:NamedThing alkenylglycerophosphocholine hydrolase activity Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphocholine = L-1-glycero-3-phosphocholine + an aldehyde. got7fsn_ti 1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase activity|lysoplasmalogenase activity RHEA:22544|MetaCyc:3.3.2.2-RXN|EC:3.3.2.2 molecular_function owl:Class
GO:0032181 biolink:NamedThing dinucleotide repeat insertion binding Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats. got7fsn_ti molecular_function owl:Class
GO:0032139 biolink:NamedThing dinucleotide insertion or deletion binding Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion. got7fsn_ti dinucleotide insertion binding molecular_function owl:Class
GO:0051237 biolink:NamedThing maintenance of RNA location Any process in which RNA is maintained in a location and prevented from moving elsewhere. got7fsn_ti maintenance of RNA localization|RNA retention biological_process owl:Class
GO:0051235 biolink:NamedThing maintenance of location Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere. got7fsn_ti maintenance of localization|retention|storage|sequestering biological_process owl:Class
GO:0030058 biolink:NamedThing amine dehydrogenase activity Catalysis of the reaction: an aliphatic amine + an acceptor (A) + H2O = an aldehyde + a reduced acceptor (AH2) + NH4+. got7fsn_ti primary-amine dehydrogenase activity|amine: (acceptor) oxidoreductase (deaminating)|methylamine dehydrogenase activity|primary-amine:acceptor oxidoreductase (deaminating)|MADH activity https://github.com/geneontology/go-ontology/issues/21650 UM-BBD_enzymeID:e0058|RHEA:51128 molecular_function owl:Class
GO:0071226 biolink:NamedThing cellular response to molecule of fungal origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. got7fsn_ti cellular response to fungus associated molecule mah 2009-12-03T01:50:01Z biological_process owl:Class
GO:0102195 biolink:NamedThing UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysinium(1+) + ATP <=> UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-D-lysine + ADP + hydrogenphosphate + H+. got7fsn_ti EC:6.3.2.37|MetaCyc:RXN-12042|RHEA:25273 molecular_function owl:Class
GO:0060643 biolink:NamedThing epithelial cell differentiation involved in mammary gland bud morphogenesis The process in which a cell of the mammary placode becomes a cell of the mammary gland bud. got7fsn_ti dph 2009-05-29T07:58:13Z biological_process owl:Class
GO:0060644 biolink:NamedThing mammary gland epithelial cell differentiation The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland. got7fsn_ti dph 2009-05-29T08:03:07Z biological_process owl:Class
GO:0047613 biolink:NamedThing aconitate decarboxylase activity Catalysis of the reaction: cis-aconitate + H(+) = CO(2) + itaconate. got7fsn_ti cis-aconitate carboxy-lyase activity|CAD activity|cis-aconitic decarboxylase activity|cis-aconitate carboxy-lyase (itaconate-forming) KEGG_REACTION:R02243|MetaCyc:ACONITATE-DECARBOXYLASE-RXN|EC:4.1.1.6|RHEA:15253 molecular_function owl:Class
GO:0110121 biolink:NamedThing gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body. got7fsn_ti kmv 2018-07-27T15:49:05Z biological_process owl:Class
GO:1990735 biolink:NamedThing gamma-tubulin complex localization to mitotic spindle pole body Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body. got7fsn_ti gamma-tubulin complex localisation to mitotic spindle pole body|establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body|gamma-tubulin complex localization to mitotic SPB mah 2015-04-29T14:40:20Z biological_process owl:Class
GO:0071109 biolink:NamedThing superior temporal gyrus development The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus. got7fsn_ti mah 2009-11-12T02:19:23Z biological_process owl:Class
GO:0042331 biolink:NamedThing phototaxis The directed movement of a motile cell or organism in response to light. got7fsn_ti phototactic behaviour|phototactic behavior|taxis in response to light GO:0046953 Wikipedia:Phototaxis biological_process owl:Class
GO:0008743 biolink:NamedThing L-threonine 3-dehydrogenase activity Catalysis of the reaction: L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + CO(2) + NADH. got7fsn_ti L-threonine dehydrogenase activity|L-threonine:NAD+ oxidoreductase activity|threonine dehydrogenase activity|threonine 3-dehydrogenase activity EC:1.1.1.103|KEGG_REACTION:R01465|MetaCyc:THREODEHYD-RXN|Reactome:R-HSA-6798667|RHEA:13161 molecular_function owl:Class
GO:0047121 biolink:NamedThing isoquinoline 1-oxidoreductase activity Catalysis of the reaction: A + H(2)O + isoquinoline = AH(2) + isoquinolin-1(2H)-one. got7fsn_ti isoquinoline:acceptor 1-oxidoreductase (hydroxylating) KEGG_REACTION:R05151|RHEA:11588|MetaCyc:1.3.99.16-RXN|EC:1.3.99.16 molecular_function owl:Class
GO:0090258 biolink:NamedThing negative regulation of mitochondrial fission Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. got7fsn_ti negative regulation of mitochondrial division tb 2010-02-03T04:05:32Z biological_process owl:Class
GO:0004555 biolink:NamedThing alpha,alpha-trehalase activity Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. got7fsn_ti alpha,alpha-trehalose glucohydrolase activity MetaCyc:TREHALA-RXN|Reactome:R-HSA-188985|RHEA:20868|EC:3.2.1.28 molecular_function owl:Class
GO:0015927 biolink:NamedThing trehalase activity Catalysis of the hydrolysis of trehalose or a trehalose derivative. got7fsn_ti MetaCyc:TREHALA-RXN|RHEA:32675 molecular_function owl:Class
GO:2000830 biolink:NamedThing positive regulation of parathyroid hormone secretion Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion. got7fsn_ti positive regulation of parathormone secretion|positive regulation of PTH secretion|positive regulation of parathyrin secretion bf 2011-07-26T08:38:00Z biological_process owl:Class
GO:0051240 biolink:NamedThing positive regulation of multicellular organismal process Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs. got7fsn_ti stimulation of multicellular organismal process|activation of multicellular organismal process|up-regulation of multicellular organismal process|up regulation of multicellular organismal process|upregulation of multicellular organismal process biological_process owl:Class
GO:0006564 biolink:NamedThing L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. got7fsn_ti L-serine formation|L-serine synthesis|L-serine anabolism|L-serine biosynthesis MetaCyc:SERSYN-PWY biological_process owl:Class
GO:0009070 biolink:NamedThing serine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. got7fsn_ti serine family amino acid synthesis|serine family amino acid anabolism|serine family amino acid biosynthesis|serine family amino acid formation biological_process owl:Class
GO:0070973 biolink:NamedThing protein localization to endoplasmic reticulum exit site A process in which a protein is transported to, or maintained in, a location at an endoplasmic reticulum exit site. got7fsn_ti protein localisation to endoplasmic reticulum exit site|protein localization to ER exit site mah 2009-10-02T12:45:41Z biological_process owl:Class
GO:0070972 biolink:NamedThing protein localization to endoplasmic reticulum A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum. got7fsn_ti protein localization in endoplasmic reticulum|protein localisation in endoplasmic reticulum|protein localization in ER mah 2009-10-02T12:43:34Z biological_process owl:Class
GO:0018805 biolink:NamedThing benzylsuccinate synthase activity Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate. got7fsn_ti benzylsuccinate fumarate-lyase (toluene-forming)|benzylsuccinate fumarate-lyase activity EC:4.1.99.11|UM-BBD_enzymeID:e0259|RHEA:10416|MetaCyc:RXN-863|KEGG_REACTION:R05598 molecular_function owl:Class
GO:0004859 biolink:NamedThing phospholipase inhibitor activity Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. got7fsn_ti molecular_function owl:Class
GO:0055102 biolink:NamedThing lipase inhibitor activity Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. got7fsn_ti molecular_function owl:Class
GO:0072102 biolink:NamedThing glomerulus morphogenesis The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. got7fsn_ti mah 2010-02-10T02:32:09Z biological_process owl:Class
GO:0030912 biolink:NamedThing response to deep water Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle. got7fsn_ti Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale. biological_process owl:Class
GO:0009415 biolink:NamedThing response to water Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. got7fsn_ti response to water stimulus biological_process owl:Class
GO:0005869 biolink:NamedThing dynactin complex A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach. got7fsn_ti cellular_component owl:Class
GO:0007483 biolink:NamedThing genital disc morphogenesis The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut. got7fsn_ti genital disc metamorphosis biological_process owl:Class
GO:0007560 biolink:NamedThing imaginal disc morphogenesis The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. got7fsn_ti imaginal disc metamorphosis GO:0007452 biological_process owl:Class
GO:0003347 biolink:NamedThing epicardial cell to mesenchymal cell transition A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium. got7fsn_ti dph 2009-12-01T11:05:39Z biological_process owl:Class
GO:0001837 biolink:NamedThing epithelial to mesenchymal transition A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. got7fsn_ti epithelial-mesenchymal transition|EMT|mesenchymal cell differentiation from epithelial cell biological_process owl:Class
GO:0031780 biolink:NamedThing corticotropin hormone receptor binding Binding to a corticotropin hormone receptor. got7fsn_ti adrenocorticotropin hormone receptor binding|ACTH receptor binding|adrenocorticotropin receptor binding|adrenocorticotropic hormone receptor ligand|corticotropin receptor binding GO:0071856 molecular_function owl:Class
GO:0001096 biolink:NamedThing TFIIF-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. got7fsn_ti TFIIF-class transcription factor binding krc 2010-10-28T02:51:20Z molecular_function owl:Class
GO:0001091 biolink:NamedThing RNA polymerase II general transcription initiation factor binding Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. got7fsn_ti RNA polymerase II basal transcription factor binding krc 2010-10-28T02:30:02Z molecular_function owl:Class
GO:0001164 biolink:NamedThing RNA polymerase I core promoter sequence-specific DNA binding Binding to a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE. got7fsn_ti RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting|RNA polymerase I core promoter sequence-specific DNA binding|RNA polymerase I core element sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding krc 2011-01-31T04:47:48Z GO:0001187 molecular_function owl:Class
GO:0001046 biolink:NamedThing core promoter sequence-specific DNA binding Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. got7fsn_ti core promoter binding https://github.com/geneontology/go-ontology/issues/19312 krc 2010-08-25T04:17:44Z GO:0001047 molecular_function owl:Class
GO:0070686 biolink:NamedThing macropinocytic cup membrane The portion of the plasma membrane surrounding a macropinocytic cup. got7fsn_ti crown membrane mah 2009-06-03T10:52:25Z cellular_component owl:Class
GO:0031253 biolink:NamedThing cell projection membrane The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection. got7fsn_ti membrane projection|membrane extension cellular_component owl:Class
GO:0005582 biolink:NamedThing collagen type XV trimer A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils. got7fsn_ti cellular_component owl:Class
GO:0034778 biolink:NamedThing 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity Catalysis of the reaction: 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA = 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1003 molecular_function owl:Class
GO:0097254 biolink:NamedThing renal tubular secretion Secretion of substances from peritubular capillaries into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs. got7fsn_ti pr 2012-03-05T02:03:58Z biological_process owl:Class
GO:0033430 biolink:NamedThing CGC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CGC codon. got7fsn_ti arginine tRNA Note that in the standard genetic code, CGC codes for arginine. molecular_function owl:Class
GO:0021703 biolink:NamedThing locus ceruleus development The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. got7fsn_ti locus caeruleus development|locus coeruleus development biological_process owl:Class
GO:0050018 biolink:NamedThing L-amino-acid dehydrogenase activity Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH. got7fsn_ti L-amino-acid:NAD+ oxidoreductase (deaminating) MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN|RHEA:10396|EC:1.4.1.5 molecular_function owl:Class
GO:0016639 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. got7fsn_ti EC:1.4.1.- molecular_function owl:Class
GO:0034830 biolink:NamedThing (2Z)-2,4-dihydroxydec-2-enedioate aldolase activity Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate. got7fsn_ti UM-BBD_reactionID:r1174|EC:4.1.3.- molecular_function owl:Class
GO:0097380 biolink:NamedThing dorsal spinal cord interneuron anterior axon guidance The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. got7fsn_ti dorsal interneuron rostral axon projection pr 2012-10-01T10:24:41Z biological_process owl:Class
GO:0034430 biolink:NamedThing monolayer-surrounded lipid storage body outer lipid monolayer The single layer of phopholipids surrounding a lipid storage body. got7fsn_ti spherosome outer lipid monolayer|oleosome outer lipid monolayer|lipid storage body surface lipid monolayer|lipid droplet outer lipid monolayer|oil body outer lipid monolayer cellular_component owl:Class
GO:0034646 biolink:NamedThing organelle-enclosing lipid monolayer A lipid monolayer that surrounds and encloses an organelle. got7fsn_ti cellular_component owl:Class
GO:0004619 biolink:NamedThing phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. got7fsn_ti diphosphoglycomutase|GriP mutase|phosphoglyceromutase activity|bisphosphoglyceromutase|D-phosphoglycerate 2,3-phosphomutase activity|PGM|monophosphoglyceromutase activity|PGA mutase activity|PGAM activity|phosphoglycerate phosphomutase activity|MPGM|monophosphoglycerate mutase activity RHEA:15901|MetaCyc:3PGAREARR-RXN|Reactome:R-HSA-71654|EC:5.4.2.1|Reactome:R-HSA-71445 molecular_function owl:Class
GO:0031696 biolink:NamedThing alpha-2C adrenergic receptor binding Binding to an alpha-2C adrenergic receptor. got7fsn_ti alpha-2C adrenergic receptor ligand molecular_function owl:Class
GO:0006165 biolink:NamedThing nucleoside diphosphate phosphorylation The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate. got7fsn_ti biological_process owl:Class
GO:0046939 biolink:NamedThing nucleotide phosphorylation The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside. got7fsn_ti biological_process owl:Class
GO:0060921 biolink:NamedThing sinoatrial node cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node. got7fsn_ti sinus node cell differentiation|SAN cell differentiation|SA node cell differentiation dph 2009-09-29T11:03:30Z biological_process owl:Class
GO:0045684 biolink:NamedThing positive regulation of epidermis development Any process that activates or increases the frequency, rate or extent of epidermis development. got7fsn_ti positive regulation of hypodermis development|positive regulation of epidermal development|stimulation of epidermis development|up regulation of epidermis development|upregulation of epidermis development|up-regulation of epidermis development|activation of epidermis development biological_process owl:Class
GO:0046809 biolink:NamedThing replication compartment Globular nuclear domains where the transcription and replication of the viral genome occurs. More than one site can be present simultaneously. got7fsn_ti RC cellular_component owl:Class
GO:0039715 biolink:NamedThing nuclear viral factory A viral factory located in the nucleus of a host cell. got7fsn_ti bf 2013-12-19T15:18:07Z cellular_component owl:Class
GO:0050365 biolink:NamedThing tryptophanamidase activity Catalysis of the reaction: L-tryptophanamide + H(2)O = L-tryptophan + NH(4)(+). got7fsn_ti L-tryptophanamide amidohydrolase activity|tryptophan aminopeptidase|L-tryptophan aminopeptidase MetaCyc:TRYPTOPHANAMIDASE-RXN|KEGG_REACTION:R00682|EC:3.5.1.57|RHEA:11012 molecular_function owl:Class
GO:0032535 biolink:NamedThing regulation of cellular component size A process that modulates the size of a cellular component. got7fsn_ti biological_process owl:Class
GO:0090066 biolink:NamedThing regulation of anatomical structure size Any process that modulates the size of an anatomical structure. got7fsn_ti tb 2009-09-02T11:00:08Z biological_process owl:Class
GO:0010444 biolink:NamedThing guard mother cell differentiation The process in which a meristemoid acquires the specialized features of a guard mother cell. got7fsn_ti biological_process owl:Class
GO:0035234 biolink:NamedThing ectopic germ cell programmed cell death Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo. got7fsn_ti programmed cell death, ectopic germ cells|programmed cell death of ectopic germ cells biological_process owl:Class
GO:0043102 biolink:NamedThing amino acid salvage Any process which produces an amino acid from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0008652 biolink:NamedThing cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. got7fsn_ti amino acid biosynthetic process|cellular amino acid biosynthesis|cellular amino acid formation|cellular amino acid anabolism|cellular amino acid synthesis Wikipedia:Amino_acid_synthesis biological_process owl:Class
GO:0102981 biolink:NamedThing 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone oxidoreductase activity Catalysis of the reaction: 4-hydroxy-5-methyl-2-propyl-3(2H)-furanone + NADP <=> (2E)-4-hydroxy-5-methyl-2-propylidene-3(2H)-furanone + NADPH + H+. got7fsn_ti MetaCyc:RXN-9567 molecular_function owl:Class
GO:0006867 biolink:NamedThing asparagine transport The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-asparagine transport biological_process owl:Class
GO:0015804 biolink:NamedThing neutral amino acid transport The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0032093 biolink:NamedThing SAM domain binding Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes. got7fsn_ti Sterile Alpha Motif domain binding molecular_function owl:Class
GO:0031219 biolink:NamedThing levanase activity Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units. got7fsn_ti 2,6-beta-D-fructan fructanohydrolase activity|levan hydrolase activity EC:3.2.1.65|MetaCyc:3.2.1.65-RXN molecular_function owl:Class
GO:2000857 biolink:NamedThing positive regulation of mineralocorticoid secretion Any process that activates or increases the frequency, rate or extent of mineralocorticoid secretion. got7fsn_ti bf 2011-07-26T08:46:45Z biological_process owl:Class
GO:2000855 biolink:NamedThing regulation of mineralocorticoid secretion Any process that modulates the frequency, rate or extent of mineralocorticoid secretion. got7fsn_ti bf 2011-07-26T08:46:38Z biological_process owl:Class
GO:0038055 biolink:NamedThing BMP secretion The controlled release of a member of the BMP family of proteins from a cell. got7fsn_ti BMP protein secretion|bone morphogenetic protein secretion bf 2011-12-14T02:31:39Z biological_process owl:Class
GO:0102603 biolink:NamedThing 12-demethyl-elloramycin C12a O-methyltransferase activity Catalysis of the reaction: 12-demethyl-elloramycin + S-adenosyl-L-methionine <=> elloramycin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-15402 molecular_function owl:Class
GO:0071039 biolink:NamedThing nuclear polyadenylation-dependent CUT catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT. got7fsn_ti nuclear poly(A)-dependent CUT catabolic process krc 2009-07-29T01:10:34Z biological_process owl:Class
GO:0071034 biolink:NamedThing CUT catabolic process The chemical reactions and pathways resulting in the breakdown of cryptic unstable transcripts (CUTs). got7fsn_ti cryptic unstable transcript catabolic process krc 2009-07-29T12:38:04Z biological_process owl:Class
GO:0007565 biolink:NamedThing female pregnancy The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. got7fsn_ti carrying of young|gestation Wikipedia:Gestation biological_process owl:Class
GO:0044706 biolink:NamedThing multi-multicellular organism process A multicellular organism process which involves another multicellular organism of the same or different species. got7fsn_ti jl 2012-09-19T16:06:16Z biological_process owl:Class
GO:0032259 biolink:NamedThing methylation The process in which a methyl group is covalently attached to a molecule. got7fsn_ti Wikipedia:Methylation biological_process owl:Class
GO:0046436 biolink:NamedThing D-alanine metabolic process The chemical reactions and pathways involving D-alanine, the D-enantiomer of the amino acid alanine, i.e. (2R)-2-aminopropanoic acid. got7fsn_ti D-alanine metabolism biological_process owl:Class
GO:0046144 biolink:NamedThing D-alanine family amino acid metabolic process The chemical reactions and pathways involving D-alanine and related amino acids. got7fsn_ti D-alanine family amino acid metabolism biological_process owl:Class
GO:0050056 biolink:NamedThing linalool 8-monooxygenase activity Catalysis of the reaction: AH(2) + linalool + O(2) = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H(2)O. got7fsn_ti 3,7-dimethylocta-1,6-dien-3-ol,hydrogen-donor:oxygen oxidoreductase (8-hydroxylating) EC:1.14.99.28|MetaCyc:LINALOOL-8-MONOOXYGENASE-RXN|RHEA:20760|KEGG_REACTION:R04366 molecular_function owl:Class
GO:0061342 biolink:NamedThing regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway Any process that decreased the extent of cell adhesion that contributes to the shaping of the heart. got7fsn_ti regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway dph 2010-09-29T11:30:15Z biological_process owl:Class
GO:0022413 biolink:NamedThing reproductive process in single-celled organism A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism. got7fsn_ti biological_process owl:Class
GO:0060949 biolink:NamedThing cardiac vascular smooth muscle cell fate commitment The commitment of cells to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell. got7fsn_ti heart vascular smooth muscle cell fate commitment dph 2009-09-29T03:02:45Z biological_process owl:Class
GO:0060911 biolink:NamedThing cardiac cell fate commitment The commitment of cells to specific cardiac cell fates and their capacity to differentiate into cardiac cells. Cardiac cells are cells that comprise the organ which pumps blood through the circulatory system. got7fsn_ti cardiocyte cell fate commitment dph 2009-09-17T08:47:00Z biological_process owl:Class
GO:0019008 biolink:NamedThing molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. got7fsn_ti molybdopterin converting factor complex GO:0019009 cellular_component owl:Class
GO:0030931 biolink:NamedThing heterotetrameric ADPG pyrophosphorylase complex A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus. got7fsn_ti cellular_component owl:Class
GO:0030929 biolink:NamedThing ADPG pyrophosphorylase complex Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits. got7fsn_ti cellular_component owl:Class
GO:0014032 biolink:NamedThing neural crest cell development The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0014031 biolink:NamedThing mesenchymal cell development The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0018009 biolink:NamedThing N-terminal peptidyl-L-cysteine N-palmitoylation The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine. got7fsn_ti RESID:AA0060 biological_process owl:Class
GO:0006500 biolink:NamedThing N-terminal protein palmitoylation The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein. got7fsn_ti biological_process owl:Class
GO:0044620 biolink:NamedThing ACP phosphopantetheine attachment site binding Binding to the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP). got7fsn_ti jl 2012-07-04T03:25:04Z molecular_function owl:Class
GO:0051192 biolink:NamedThing prosthetic group binding Binding to a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. got7fsn_ti molecular_function owl:Class
GO:0071342 biolink:NamedThing regulation of establishment of actomyosin contractile ring localization Any process that modulates the frequency, rate or extent of the process in which a contractile ring is assembled in a specific location that contributes to cytokinesis during cell cycle. got7fsn_ti regulation of establishment of contractile ring localization involved in cell cycle cytokinesis|regulation of establishment of contractile ring localization involved in cytokinesis during cell cycle|regulation of establishment of contractile ring localisation involved in cell cycle cytokinesis mah 2009-12-11T01:22:11Z biological_process owl:Class
GO:0044087 biolink:NamedThing regulation of cellular component biogenesis Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. got7fsn_ti biological_process owl:Class
GO:0102946 biolink:NamedThing soyasapogenol E UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + soyasapogenol E <=> UDP + a soyasapogenol E monoglucoside. got7fsn_ti MetaCyc:RXN-9038 molecular_function owl:Class
GO:0044058 biolink:NamedThing regulation of digestive system process Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class
GO:0002939 biolink:NamedThing tRNA N1-guanine methylation The process whereby a guanine in tRNA is methylated at position N1 of the guanine. got7fsn_ti tRNA m1-guanine biosynthesis hjd 2012-11-09T16:18:41Z biological_process owl:Class
GO:0060471 biolink:NamedThing cortical granule exocytosis The process of secretion by a cell that results in the release of intracellular molecules contained within a cortical granule by fusion of the vesicle with the plasma membrane of a cell. A cortical granule is a specialized secretory vesicle that is released during egg activation that changes the surface of the egg to prevent polyspermy. got7fsn_ti cortical reaction|cortical granule release https://github.com/geneontology/go-ontology/issues/13980 biological_process owl:Class
GO:0017156 biolink:NamedThing calcium-ion regulated exocytosis The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. got7fsn_ti calcium ion-dependent exocytosis Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway. biological_process owl:Class
GO:0000743 biolink:NamedThing nuclear migration involved in conjugation with cellular fusion The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion. got7fsn_ti nuclear congression|nuclear migration during conjugation with cellular fusion GO:0006946 biological_process owl:Class
GO:0030473 biolink:NamedThing nuclear migration along microtubule The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. got7fsn_ti nuclear movement, microtubule-mediated|transport of nucleus, microtubule-mediated|microtubule cytoskeleton-dependent nucleus positioning|microtubule-dependent nuclear positioning|transport of nucleus by microtubules|microtubule cytoskeleton-dependent nuclear positioning|nucleus migration|microtubule-dependent nucleus positioning|nuclear migration, microtubule-mediated|microtubule-mediated nuclear migration GO:0000065 biological_process owl:Class
GO:0008096 biolink:NamedThing juvenile hormone epoxide hydrolase activity Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol. got7fsn_ti EC:3.3.2.- molecular_function owl:Class
GO:0004301 biolink:NamedThing epoxide hydrolase activity Catalysis of the reaction: an epoxide + H2O = a glycol. got7fsn_ti aryl epoxide hydrase activity|sEH|trans-stilbene oxide hydrolase activity|epoxide hydrase activity|soluble epoxide hydrolase activity|epoxide hydratase activity|cytosolic epoxide hydrolase activity|arene-oxide hydratase activity Reactome:R-HSA-9020257|RHEA:19037|Reactome:R-HSA-9018862|Reactome:R-HSA-9024973|Reactome:R-HSA-9020270|EC:3.3.2.10|Reactome:R-HSA-9020258|Reactome:R-HSA-9026008|MetaCyc:3.3.2.10-RXN|Reactome:R-HSA-9026000|Reactome:R-HSA-9020252|Reactome:R-HSA-9020253|UM-BBD_enzymeID:e0397|Reactome:R-HSA-9025998|Reactome:R-HSA-9018877|Reactome:R-HSA-9024993|Reactome:R-HSA-9024890|Reactome:R-HSA-2161961 molecular_function owl:Class
GO:0001550 biolink:NamedThing ovarian cumulus expansion Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells. got7fsn_ti ovarian cumulus growth biological_process owl:Class
GO:0006783 biolink:NamedThing heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. got7fsn_ti heme biosynthesis|heme formation|haem biosynthesis|heme synthesis|haem biosynthetic process|heme anabolism MetaCyc:HEMESYN2-PWY biological_process owl:Class
GO:0060343 biolink:NamedThing trabecula formation The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. got7fsn_ti trabecula biogenesis|trabeculation biological_process owl:Class
GO:0017099 biolink:NamedThing very-long-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. got7fsn_ti very long-chain-acyl-CoA dehydrogenase activity Reactome:R-HSA-548831 molecular_function owl:Class
GO:0004466 biolink:NamedThing long-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF. got7fsn_ti palmitoyl-coenzyme A dehydrogenase activity|palmitoyl-CoA dehydrogenase activity|long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity|long-chain acyl-coenzyme A dehydrogenase activity|long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity EC:1.3.8.8|RHEA:17721|MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0048200 biolink:NamedThing Golgi transport vesicle coating The addition of specific coat proteins to Golgi membranes during the formation of transport vesicles. got7fsn_ti dictyosome transport vesicle coating biological_process owl:Class
GO:0006901 biolink:NamedThing vesicle coating A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination. got7fsn_ti vesicle coat assembly biological_process owl:Class
GO:1990907 biolink:NamedThing beta-catenin-TCF complex A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. got7fsn_ti beta-catenin/LEF complex|beta-catenin/T-cell factor complex|beta-catenin/lymphoid enhancer binding factor complex bf 2015-12-01T16:32:44Z cellular_component owl:Class
GO:0090575 biolink:NamedThing RNA polymerase II transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. got7fsn_ti RNA polymerase II transcription factor complex tb 2014-05-09T14:04:37Z cellular_component owl:Class
GO:0030054 biolink:NamedThing cell junction A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. got7fsn_ti Wikipedia:Cell_junction cellular_component owl:Class
GO:0021791 biolink:NamedThing chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme biological_process owl:Class
GO:0021789 biolink:NamedThing branchiomotor neuron axon guidance in branchial arch mesenchyme The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti biological_process owl:Class
GO:0097021 biolink:NamedThing lymphocyte migration into lymphoid organs The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. got7fsn_ti lymphocyte homing pr 2011-03-29T04:26:08Z biological_process owl:Class
GO:0072676 biolink:NamedThing lymphocyte migration The movement of a lymphocyte within or between different tissues and organs of the body. got7fsn_ti mah 2011-02-22T03:38:12Z biological_process owl:Class
GO:0019728 biolink:NamedThing peptidyl-allysine oxidation to 2-aminoadipic acid The oxidation of allysine to 2-aminoadipic acid. got7fsn_ti RESID:AA0370 biological_process owl:Class
GO:0018158 biolink:NamedThing protein oxidation The modification of a protein amino acid by oxidation. got7fsn_ti protein amino acid oxidation biological_process owl:Class
GO:0031978 biolink:NamedThing plastid thylakoid lumen The volume enclosed by a plastid thylakoid membrane. got7fsn_ti cellular_component owl:Class
GO:0031977 biolink:NamedThing thylakoid lumen The volume enclosed by a thylakoid membrane. got7fsn_ti cellular_component owl:Class
GO:0031785 biolink:NamedThing type 1A melatonin receptor binding Binding to a type 1A melatonin receptor. got7fsn_ti type 1A melatonin receptor ligand molecular_function owl:Class
GO:0031784 biolink:NamedThing melatonin receptor binding Binding to a melatonin receptor. got7fsn_ti melatonin receptor ligand molecular_function owl:Class
GO:0033819 biolink:NamedThing lipoyl(octanoyl) transferase activity Catalysis of the reaction: octanoyl-[acyl-carrier protein] + protein = protein N6-(octanoyl)lysine + acyl-carrier protein. got7fsn_ti octanoyl-acyl-carrier-protein:protein N-octanoyltransferase activity|lipoyl (octanoyl)-acyl carrier protein:protein transferase activity|lipoate/octanoate transferase activity|LipB|octanoyl-acyl carrier protein-protein N-octanoyltransferase activity|lipoyl (octanoyl)-acyl-carrier-protein-protein N-lipoyltransferase activity|octanoyl-acyl-carrier-protein-protein N-octanoyltransferase activity Reactome:R-HSA-6793590|MetaCyc:RXN0-947|EC:2.3.1.181 molecular_function owl:Class
GO:0070762 biolink:NamedThing nuclear pore transmembrane ring A subcomplex of the nuclear pore complex (NPC) that spans the nuclear membrane and anchors the NPC to the nuclear envelope. In S. cerevisiae, the transmembrane ring is composed of Pom152p, Pom34p, and Ndc1p. In vertebrates, it is composed of Gp210, Ndc1, and Pom121. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometime referred to as the Ndc1 complex. got7fsn_ti NDC1 subcomplex|NDC1 complex mah 2009-06-29T11:02:56Z cellular_component owl:Class
GO:0098843 biolink:NamedThing postsynaptic endocytic zone A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins. got7fsn_ti cellular_component owl:Class
GO:0061163 biolink:NamedThing endoplasmic reticulum polarization The endoplasmic reticulum organization process that results in the structure of the endoplasmic reticulum being oriented in the cell. Endoplasmic reticulum polarization serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. got7fsn_ti establishment of endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site|ER polarization|establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site|endoplasmic reticulum localisation involved in endoplasmic reticulum polarization at cell division site|ER localization involved in ER polarization at cell division site|endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site|transitional endoplasmic reticulum polarization at cell division site|maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site https://github.com/geneontology/go-ontology/issues/20666 dph 2010-06-25T09:51:48Z GO:0061166|GO:0061165|GO:0061164|GO:0061167 biological_process owl:Class
GO:0007029 biolink:NamedThing endoplasmic reticulum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum. got7fsn_ti ER organisation|endoplasmic reticulum morphology|ER organization and biogenesis|endoplasmic reticulum organization and biogenesis|endoplasmic reticulum organisation biological_process owl:Class
GO:0060220 biolink:NamedThing camera-type eye photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell in a camera-type eye. got7fsn_ti biological_process owl:Class
GO:0042706 biolink:NamedThing eye photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. got7fsn_ti biological_process owl:Class
GO:0097167 biolink:NamedThing circadian regulation of translation Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours. got7fsn_ti regulation of mRNA translation in response to circadian clock pr 2011-09-29T03:13:31Z biological_process owl:Class
GO:0007623 biolink:NamedThing circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours. got7fsn_ti circadian response|circadian process|response to circadian rhythm GO:0050895 Wikipedia:Circadian_rhythm biological_process owl:Class
GO:0030742 biolink:NamedThing GTP-dependent protein binding Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state. got7fsn_ti This term may be used to annotate both partners in a GTP-dependent binding interaction, both the GTP-bound protein and the protein(s) which interact with it. molecular_function owl:Class
GO:0061791 biolink:NamedThing GTPase motor activity A motor activity driven by GTP hydrolysis. got7fsn_ti dph 2016-09-09T13:17:29Z molecular_function owl:Class
GO:0003924 biolink:NamedThing GTPase activity Catalysis of the reaction: GTP + H2O = GDP + phosphate. got7fsn_ti heterotrimeric G-protein GTPase, beta-subunit|hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement|tubulin GTPase activity|heterotrimeric G-protein GTPase, gamma-subunit|protein-synthesizing GTPase activity, initiation|Rho small monomeric GTPase activity|protein-synthesizing GTPase activity, termination|heterotrimeric G-protein GTPase, alpha-subunit|signal-recognition-particle GTPase activity|heterotrimeric G-protein GTPase activity|Ran small monomeric GTPase activity|small monomeric GTPase activity|Sar small monomeric GTPase activity|protein-synthesizing GTPase activity, elongation|RHEB small monomeric GTPase activity|Ras small monomeric GTPase activity|Rab small monomeric GTPase activity|ARF small monomeric GTPase activity|GTPase activity, coupled|dynamin GTPase activity|protein-synthesizing GTPase activity https://github.com/geneontology/go-ontology/issues/19078 dph 2015-11-11T12:47:56Z GO:0061745 Reactome:R-HSA-5658231|Reactome:R-HSA-5623513|Reactome:R-HSA-380979|Reactome:R-HSA-5694527|Reactome:R-HSA-2130641|Reactome:R-HSA-156923|Reactome:R-HSA-8982025|Reactome:R-HSA-170686|Reactome:R-HSA-164381|Reactome:R-HSA-983422|Reactome:R-HSA-6814833|Reactome:R-HSA-9649736|Reactome:R-HSA-5389842|Reactome:R-HSA-392212|Reactome:R-HSA-421835|Reactome:R-HSA-8854255|Reactome:R-HSA-8868661|Reactome:R-HSA-177501|Reactome:R-HSA-5419279|Reactome:R-HSA-555065|Reactome:R-HSA-8847534|Reactome:R-HSA-9640195|Reactome:R-HSA-428941|Reactome:R-HSA-167415|Reactome:R-HSA-6807877|Reactome:R-HSA-5419273|Reactome:R-HSA-8854604|Reactome:R-HSA-5665809|Reactome:R-HSA-8854329|Reactome:R-HSA-8854173|Reactome:R-HSA-8849082|Reactome:R-HSA-1445143|Reactome:R-HSA-418574|Reactome:R-HSA-5389839|Reactome:R-HSA-2130725|Reactome:R-HSA-5638006|Reactome:R-HSA-432707|Reactome:R-HSA-8854612|Reactome:R-HSA-1458485|Reactome:R-HSA-5333615|Reactome:R-HSA-9645598|Reactome:R-HSA-418582|Reactome:R-HSA-5672017|Reactome:R-HSA-8982021|Reactome:R-HSA-165055|Reactome:R-HSA-2584246|Reactome:R-HSA-170666|Reactome:R-HSA-8981353|Reactome:R-HSA-8982020|Reactome:R-HSA-8847883|Reactome:R-HSA-392133|Reactome:R-HSA-203973|RHEA:19669|Reactome:R-HSA-170685 molecular_function owl:Class
GO:0075135 biolink:NamedThing suppression by symbiont of host calcium or calmodulin-mediated signal transduction Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction|negative regulation by symbiont of host calcium or calmodulin-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075105". biological_process owl:Class
GO:0075133 biolink:NamedThing modulation by symbiont of host calcium or calmodulin-mediated signal transduction Any process in which the symbiont modulates the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host Ca++ or calmodulin-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075103". biological_process owl:Class
GO:1900613 biolink:NamedThing F-9775B catabolic process The chemical reactions and pathways resulting in the breakdown of F-9775B. got7fsn_ti F-9775B breakdown|F-9775B degradation|F-9775B catabolism di 2012-05-15T07:03:24Z biological_process owl:Class
GO:0090487 biolink:NamedThing secondary metabolite catabolic process The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. got7fsn_ti secondary metabolite degradation|secondary metabolite breakdown|secondary metabolite catabolism tb 2012-10-15T16:43:09Z biological_process owl:Class
GO:1904364 biolink:NamedThing positive regulation of calcitonin secretion Any process that activates or increases the frequency, rate or extent of calcitonin secretion. got7fsn_ti up-regulation of calcitonin secretion|up regulation of calcitonin secretion|upregulation of calcitonin secretion|activation of calcitonin secretion sl 2015-06-15T17:55:05Z biological_process owl:Class
GO:0004078 biolink:NamedThing biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)). got7fsn_ti biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)|beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity|biotin-methylcrotonoyl-CoA-carboxylase synthetase|biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity|biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity|biotin-methylcrotonoyl-CoA-carboxylase ligase activity MetaCyc:6.3.4.11-RXN|RHEA:24376|EC:6.3.4.11 molecular_function owl:Class
GO:0018271 biolink:NamedThing biotin-protein ligase activity Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein. got7fsn_ti biotin-apoprotein ligase activity GO:0000106 MetaCyc:BIOTINLIG-RXN|Reactome:R-HSA-9035987|Reactome:R-HSA-2993447|Reactome:R-HSA-9035990|Reactome:R-HSA-3323184|Reactome:R-HSA-9035988|Reactome:R-HSA-2993802|Reactome:R-HSA-2993799|EC:6.3.4.-|Reactome:R-HSA-4167511|Reactome:R-HSA-2993814 molecular_function owl:Class
GO:0043025 biolink:NamedThing neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. got7fsn_ti neuron cell body|neuronal cell soma Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. NIF_Subcellular:sao1044911821|Wikipedia:Soma_(biology) cellular_component owl:Class
GO:0044297 biolink:NamedThing cell body The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. got7fsn_ti cell soma Note that 'cell body' and 'cell soma' are not used in the literature for cells that lack projections, nor for some cells (e.g. yeast with mating projections) that do have projections. jl 2010-02-05T10:37:16Z FBbt:00005107|FMA:67301|Wikipedia:Cell_body cellular_component owl:Class
GO:1900572 biolink:NamedThing diorcinol biosynthetic process The chemical reactions and pathways resulting in the formation of diorcinol. got7fsn_ti diorcinol biosynthesis|diorcinol anabolism|diorcinol formation|diorcinol synthesis di 2012-05-15T06:35:29Z biological_process owl:Class
GO:0001854 biolink:NamedThing complement component C3d binding Binding to a C3d product of the complement cascade. got7fsn_ti molecular_function owl:Class
GO:0001848 biolink:NamedThing complement binding Binding to a component or product of the complement cascade. got7fsn_ti Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. molecular_function owl:Class
GO:0007394 biolink:NamedThing dorsal closure, elongation of leading edge cells The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis. got7fsn_ti biological_process owl:Class
GO:0034249 biolink:NamedThing negative regulation of cellular amide metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides. got7fsn_ti negative regulation of amide metabolism biological_process owl:Class
GO:0034248 biolink:NamedThing regulation of cellular amide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides. got7fsn_ti regulation of amide metabolism biological_process owl:Class
GO:0010233 biolink:NamedThing phloem transport The directed movement of substances, into, out of or within the phloem during long distance transport between source and sink tissues. got7fsn_ti biological_process owl:Class
GO:0010232 biolink:NamedThing vascular transport The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane. got7fsn_ti biological_process owl:Class
GO:0005813 biolink:NamedThing centrosome A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. got7fsn_ti Wikipedia:Centrosome cellular_component owl:Class
GO:0005815 biolink:NamedThing microtubule organizing center An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. got7fsn_ti MTOC|microtubule organising centre Wikipedia:Microtubule_organizing_center cellular_component owl:Class
GO:0061664 biolink:NamedThing Pup ligase activity Catalysis of the transfer of Pup to a substrate protein via the reaction X-Pup + S --> X + S-Pup, where X is either an E2 or E3 enzyme, the X-Pup linkage is a thioester bond, and the S-Pup linkage is an isopeptide bond between the C-terminal amino acid of Pup and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T13:59:09Z molecular_function owl:Class
GO:0006119 biolink:NamedThing oxidative phosphorylation The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis. got7fsn_ti respiratory-chain phosphorylation Wikipedia:Oxidative_phosphorylation biological_process owl:Class
GO:0006091 biolink:NamedThing generation of precursor metabolites and energy The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. got7fsn_ti metabolic energy generation|intermediary metabolism|energy pathways biological_process owl:Class
GO:0001667 biolink:NamedThing ameboidal-type cell migration Cell migration that is accomplished by extension and retraction of a pseudopodium. got7fsn_ti amoeboid cell migration|amoeboidal cell migration|ameboid cell migration Note that this term refers to a mode of migration rather than to any particular cell type. biological_process owl:Class
GO:0016477 biolink:NamedThing cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. got7fsn_ti Wikipedia:Cell_migration biological_process owl:Class
GO:0019697 biolink:NamedThing L-xylitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate. got7fsn_ti L-xylitol utilization|L-xylitol degradation to xylulose 5-phosphate|L-xylitol breakdown to xylulose 5-phosphate|L-arabitol and xylitol degradation MetaCyc:LARABITOLUTIL-PWY biological_process owl:Class
GO:1901159 biolink:NamedThing xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of xylulose 5-phosphate. got7fsn_ti xylulose 5-phosphate formation|xylulose 5-phosphate biosynthesis|xylulose 5-phosphate synthesis|xylulose 5-phosphate anabolism bf 2012-07-18T04:42:24Z biological_process owl:Class
GO:0048654 biolink:NamedThing anther morphogenesis The process in which the anatomical structures of the anther are generated and organized. got7fsn_ti biological_process owl:Class
GO:0004549 biolink:NamedThing tRNA-specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. got7fsn_ti tRNA-specific RNase activity Reactome:R-HSA-5696815|Reactome:R-HSA-6786854|Reactome:R-HSA-6785722|Reactome:R-HSA-5696813 molecular_function owl:Class
GO:0061482 biolink:NamedThing response to irinotecan Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus. got7fsn_ti dph 2012-11-07T09:15:03Z biological_process owl:Class
GO:0071252 biolink:NamedThing cellular response to sulfur dioxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus. got7fsn_ti mah 2009-12-03T03:10:16Z biological_process owl:Class
GO:0019676 biolink:NamedThing ammonia assimilation cycle The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen. got7fsn_ti glutamate metabolism via glutamine and ammonia|glutamate metabolic process via glutamine and ammonia MetaCyc:PWY-3282|MetaCyc:AMMASSIM-PWY biological_process owl:Class
GO:0019740 biolink:NamedThing nitrogen utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism. got7fsn_ti biological_process owl:Class
GO:1990748 biolink:NamedThing cellular detoxification Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. got7fsn_ti vw 2015-05-18T16:17:46Z biological_process owl:Class
GO:0035595 biolink:NamedThing N-acetylglucosaminylinositol deacetylase activity Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol. got7fsn_ti 1-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol acetylhydrolase activity|GlcNAc-Ins deacetylase activity|1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase activity|N-acetyl-1D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase activity bf 2010-11-11T02:12:48Z EC:3.5.1.103|KEGG_REACTION:R09651|RHEA:26180|MetaCyc:RXN1G-2 molecular_function owl:Class
GO:0000152 biolink:NamedThing nuclear ubiquitin ligase complex A ubiquitin ligase complex found in the nucleus. got7fsn_ti cellular_component owl:Class
GO:0060389 biolink:NamedThing pathway-restricted SMAD protein phosphorylation The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor. got7fsn_ti R-SMAD protein phosphorylation|pathway restricted SMAD protein phosphorylation|receptor regulated SMAD protein phosphorylation|receptor-regulated SMAD protein phosphorylation biological_process owl:Class
GO:0006468 biolink:NamedThing protein phosphorylation The process of introducing a phosphate group on to a protein. got7fsn_ti protein amino acid phosphorylation biological_process owl:Class
GO:0047182 biolink:NamedThing alcohol O-cinnamoyltransferase activity Catalysis of the reaction: an alcohol + 1-O-trans-cinnamoyl-beta-D-glucopyranose = beta-D-glucose + alkyl cinnamate. got7fsn_ti 1-O-trans-cinnamoyl-beta-D-glucopyranose:alcohol O-cinnamoyltransferase activity MetaCyc:2.3.1.152-RXN|EC:2.3.1.152|RHEA:23524 molecular_function owl:Class
GO:0048601 biolink:NamedThing oocyte morphogenesis The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte. got7fsn_ti oocyte morphogenesis during differentiation biological_process owl:Class
GO:0034875 biolink:NamedThing caffeine oxidase activity Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O. got7fsn_ti EC:1.17.5.2|RHEA:47148|UM-BBD_reactionID:r1321 molecular_function owl:Class
GO:0033695 biolink:NamedThing oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a quinone or similar acceptor molecule. got7fsn_ti EC:1.17.5.- molecular_function owl:Class
GO:0008317 biolink:NamedThing gurken receptor binding Binding to a gurken growth factor receptor. got7fsn_ti gurken receptor ligand molecular_function owl:Class
GO:0005154 biolink:NamedThing epidermal growth factor receptor binding Binding to an epidermal growth factor receptor. got7fsn_ti transforming growth factor alpha receptor binding|transforming growth factor alpha receptor ligand|EGF receptor ligand|EGF|epidermal growth factor receptor ligand|epidermal growth factor|TGF-alpha receptor binding|EGFR binding|transforming growth factor alpha|TGFalpha receptor binding|EGF receptor binding GO:0008185 molecular_function owl:Class
GO:0005542 biolink:NamedThing folic acid binding Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. got7fsn_ti vitamin B9 binding|vitamin M binding|folate binding molecular_function owl:Class
GO:0010441 biolink:NamedThing guard cell development The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0031812 biolink:NamedThing P2Y1 nucleotide receptor binding Binding to a P2Y1 nucleotide receptor. got7fsn_ti P2Y1 nucleotide receptor ligand molecular_function owl:Class
GO:0031811 biolink:NamedThing G protein-coupled nucleotide receptor binding Binding to a G protein-coupled (metabotropic) nucleotide receptor. got7fsn_ti G-protein coupled nucleotide receptor binding|metabotropic nucleotide receptor binding|P2Y receptor binding|metabotropic nucleotide receptor ligand molecular_function owl:Class
GO:0046239 biolink:NamedThing phthalate catabolic process The chemical reactions and pathways resulting in the breakdown of phthalate, the anion of phthalic acid. got7fsn_ti phthalate degradation|phthalate breakdown|phthalate catabolism biological_process owl:Class
GO:0040013 biolink:NamedThing negative regulation of locomotion Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism. got7fsn_ti down-regulation of locomotion|down regulation of locomotion|downregulation of locomotion|inhibition of locomotion biological_process owl:Class
GO:0048519 biolink:NamedThing negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. got7fsn_ti down regulation of biological process|downregulation of biological process|inhibition of biological process|negative regulation of physiological process|down-regulation of biological process GO:0043118 biological_process owl:Class
GO:1904251 biolink:NamedThing regulation of bile acid metabolic process Any process that modulates the frequency, rate or extent of bile acid metabolic process. got7fsn_ti regulation of bile acid metabolism bf 2015-05-20T11:04:28Z biological_process owl:Class
GO:0003106 biolink:NamedThing negative regulation of glomerular filtration by angiotensin The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. got7fsn_ti regulation of glomerular filtration by angiotensin|angiotensin-mediated regulation of glomerular filtration biological_process owl:Class
GO:0003083 biolink:NamedThing negative regulation of renal output by angiotensin The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney. got7fsn_ti angiotensin mediated negative regulation of renal output|angiotensin-mediated negative regulation of renal output biological_process owl:Class
GO:0005778 biolink:NamedThing peroxisomal membrane The lipid bilayer surrounding a peroxisome. got7fsn_ti peroxisome membrane cellular_component owl:Class
GO:0031903 biolink:NamedThing microbody membrane The lipid bilayer surrounding a microbody. got7fsn_ti cellular_component owl:Class
GO:0006730 biolink:NamedThing one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. got7fsn_ti one carbon metabolic process|one-carbon transfer metabolism|one-carbon transfer metabolic process|one-carbon metabolism|one carbon metabolism GO:0019753|GO:0019754 UM-BBD_pathwayID:C1cyc biological_process owl:Class
GO:0044281 biolink:NamedThing small molecule metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. got7fsn_ti small molecule metabolism Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. jl 2010-01-26T12:05:20Z biological_process owl:Class
GO:0046012 biolink:NamedThing positive regulation of oskar mRNA translation Any process that activates or increases the frequency, rate or extent of oskar mRNA translation. got7fsn_ti activation of oskar mRNA translation|up-regulation of oskar mRNA translation|stimulation of oskar mRNA translation|upregulation of oskar mRNA translation|up regulation of oskar mRNA translation biological_process owl:Class
GO:0060910 biolink:NamedThing negative regulation of DNA replication initiation involved in plasmid copy number maintenance Any process that decreases the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance. got7fsn_ti dph 2009-09-04T02:56:29Z biological_process owl:Class
GO:0032297 biolink:NamedThing negative regulation of DNA-dependent DNA replication initiation Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication. got7fsn_ti inhibition of DNA replication initiation|down-regulation of DNA replication initiation|down regulation of DNA replication initiation|downregulation of DNA replication initiation|negative regulation of DNA replication initiation biological_process owl:Class
GO:0071903 biolink:NamedThing protein N-linked N-acetylglucosaminylation via asparagine A process of protein N-linked glycosylation via asparagine in which N-acetylglucosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)amino-4-oxobutanoic acid residue. got7fsn_ti protein amino acid N-linked N-acetylglucosaminylation via asparagine mah 2010-09-15T03:49:16Z RESID:AA0151 biological_process owl:Class
GO:0018279 biolink:NamedThing protein N-linked glycosylation via asparagine The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. got7fsn_ti protein amino acid N-linked glycosylation via asparagine biological_process owl:Class
GO:0090649 biolink:NamedThing response to oxygen-glucose deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. got7fsn_ti response to OGD tb 2015-07-01T10:27:29Z biological_process owl:Class
GO:0036293 biolink:NamedThing response to decreased oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. got7fsn_ti response to lowered oxygen levels This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. bf 2012-07-20T01:05:46Z biological_process owl:Class
GO:0090353 biolink:NamedThing polygalacturonase inhibitor activity Binds to and stops, prevents or reduces the activity of polygalacturonase. got7fsn_ti tb 2010-06-15T04:19:49Z molecular_function owl:Class
GO:0004857 biolink:NamedThing enzyme inhibitor activity Binds to and stops, prevents or reduces the activity of an enzyme. got7fsn_ti metalloenzyme inhibitor activity This term should only be used in cases when the regulator directly interacts with the enzyme. GO:0048551 molecular_function owl:Class
GO:0044019 biolink:NamedThing histone acetyltransferase activity (H3-K72 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K72 specific) molecular_function owl:Class
GO:0010484 biolink:NamedThing H3 histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3. got7fsn_ti molecular_function owl:Class
GO:0060946 biolink:NamedThing cardiac blood vessel endothelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels. got7fsn_ti dph 2009-09-29T02:48:55Z biological_process owl:Class
GO:0060837 biolink:NamedThing blood vessel endothelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. got7fsn_ti dph 2009-08-11T03:47:36Z biological_process owl:Class
GO:0035266 biolink:NamedThing meristem growth The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation. got7fsn_ti biological_process owl:Class
GO:0097207 biolink:NamedThing bud dormancy process A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a bud. Bud dormancy is a suspension of most physiological activity and growth that can be reactivated. It may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. The exit from bud dormancy is marked by the resumed growth of the bud. got7fsn_ti bud dormancy Bud dormancy may precede dormancy of the whole plant. pr 2012-01-04T01:18:24Z biological_process owl:Class
GO:0050119 biolink:NamedThing N-acetylglucosamine deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate. got7fsn_ti acetylaminodeoxyglucose acetylhydrolase activity|N-acetyl-D-glucosamine amidohydrolase activity|N-acetyl-D-glucosaminyl N-deacetylase activity RHEA:20593|MetaCyc:N-ACETYLGLUCOSAMINE-DEACETYLASE-RXN|KEGG_REACTION:R01200|EC:3.5.1.33|Reactome:R-HSA-2022887 molecular_function owl:Class
GO:0106003 biolink:NamedThing amyloid-beta complex Protein complex involved in modulation of signaling and synaptic function in the brain, predominantly in the cerebral cortex and hippocampus. Forms dimers and multimers of amyloid beta peptide 40 and peptide 42 (proteolytic cleavage products of amyloid beta A4 protein, also known as amyloid beta precursor protein). Mostly found in the extracellular space with a proportion occurring as membrane-bound species. Influences synaptic plasticity through various receptors, mediates dendritic spine loss leading to decreased synapse density, inhibits long-term potentiation (LTP) and enhances long-term depression (LTD). Soluble multimeric form is the main pathogenic species linked to Alzheimer's disease. got7fsn_ti amyloid-beta protein 40 complex|heterodimer of amyloid beta protein|beta-amyloid complex|heterooligomer of amyloid beta protein|amyloid beta heterotrimer|Abeta-derived diffusible ligand complex|amyloid beta homodimer|amyloid beta complex|amyloid beta dimer|betaA complex|amyloid beta heterodimer|ADDL complex|amyloid-beta protein 42 complex|homodimer of amyloid beta protein|amyloid beta trimer|amyloid beta heterooligomer|amyloid beta homotrimer|homotrimer of amyloid beta protein|amyloid beta oligomer|homooligomer of amyloid beta protein|heterotrimer of amyloid beta protein|amyloid beta homooligomer|amyloid-beta protein 40/42 complex|beta amyloid complex|Abeta complex An example is Protein 40 of APP (P05067-PRO_0000000093) in PMID:18568035 (inferred by direct assay). hjd 2017-03-15T19:19:29Z cellular_component owl:Class
GO:1990012 biolink:NamedThing complex laminated body A cytoplasmic inclusion body found in some lateral geniculate neurons and composed of sheets of tubules (25 nm in diameter) separated by dense material (about 75 nm wide), which together with the tubules whorl give a structure resembling a fingerprint. got7fsn_ti CLB pr 2012-12-12T14:18:15Z NIF_Subcellular:nlx_151681 cellular_component owl:Class
GO:1990011 biolink:NamedThing laminated body Inclusion body characterized by regularly spaced sheets of tubules arranged in a whorl pattern resembling a fingerprint. Laminated bodies have been observed in neurons of the lateral geniculate nucleus. got7fsn_ti laminated inclusion body pr 2012-12-12T14:12:21Z NIF_Subcellular:sao506721981 cellular_component owl:Class
GO:0002266 biolink:NamedThing follicular dendritic cell activation A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti biological_process owl:Class
GO:0004499 biolink:NamedThing N,N-dimethylaniline monooxygenase activity Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. got7fsn_ti dimethylaniline oxidase activity|flavin mixed function oxidase activity|N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)|FMO5|1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity|FMO-I|dimethylaniline monooxygenase (N-oxide-forming) activity|mixed-function amine oxidase activity|FMO activity|Ziegler's enzyme|FMO1|FMO-II|DMA oxidase activity|FAD-containing monooxygenase activity|flavin monooxygenase activity|flavin-containing monooxygenase activity|FMO3|methylphenyltetrahydropyridine N-monooxygenase activity|dimethylaniline N-oxidase activity|FMO2|FMO4 GO:0047076 Reactome:R-HSA-5602966|Reactome:R-HSA-217255|MetaCyc:1.14.13.8-RXN|EC:1.14.13.8|Reactome:R-HSA-139970|RHEA:24468 molecular_function owl:Class
GO:0018515 biolink:NamedThing pimeloyl-CoA dehydrogenase activity Catalysis of the reaction: NAD(+) + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H(+) + NADH. got7fsn_ti pimeloyl-CoA:NAD+ oxidoreductase activity UM-BBD_reactionID:r0194|RHEA:19665|EC:1.3.1.62|MetaCyc:1.3.1.62-RXN|KEGG_REACTION:R05311 molecular_function owl:Class
GO:0031297 biolink:NamedThing replication fork processing The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes. got7fsn_ti recovery from replication fork stalling|replication fork restart|recovery from replication fork arrest at rDNA locus|replication restart|recovery from replication fork arrest|collapsed replication fork processing|replication fork processing at ribosomal DNA locus|replication fork processing at rDNA locus|recovery from replication fork stalling at rDNA locus GO:0034065 biological_process owl:Class
GO:0045005 biolink:NamedThing DNA-dependent DNA replication maintenance of fidelity A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. got7fsn_ti maintenance of fidelity during DNA-dependent DNA replication|maintenance of fidelity involved in DNA-dependent DNA replication biological_process owl:Class
GO:0002221 biolink:NamedThing pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. got7fsn_ti pathogen receptor signaling pathway|pathogen receptor signalling pathway|PRR signaling pathway|PAMP receptor signaling pathway https://github.com/geneontology/go-ontology/issues/18588 biological_process owl:Class
GO:0002764 biolink:NamedThing immune response-regulating signaling pathway The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response. got7fsn_ti immune response-regulating signalling pathway biological_process owl:Class
GO:0004743 biolink:NamedThing pyruvate kinase activity Catalysis of the reaction: = ADP + H(+) + phosphoenolpyruvate => ATP + pyruvate. got7fsn_ti phosphoenol transphosphorylase activity|phosphoenolpyruvate kinase activity|ATP:pyruvate 2-O-phosphotransferase activity MetaCyc:PEPDEPHOS-RXN|RHEA:18159|EC:2.7.1.40|Reactome:R-HSA-71670 molecular_function owl:Class
GO:0048482 biolink:NamedThing plant ovule morphogenesis The process in which the anatomical structures of the ovule are generated and organized. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. got7fsn_ti biological_process owl:Class
GO:0002445 biolink:NamedThing type II hypersensitivity An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors. got7fsn_ti Wikipedia:Type_II_hypersensitivity biological_process owl:Class
GO:0002444 biolink:NamedThing myeloid leukocyte mediated immunity Any process involved in the carrying out of an immune response by a myeloid leukocyte. got7fsn_ti myeloid leucocyte mediated immunity|myeloid leukocyte immune effector process|myeloid leucocyte immune effector process biological_process owl:Class
GO:0099510 biolink:NamedThing calcium ion binding involved in regulation of cytosolic calcium ion concentration The directed change of cytosolic calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in cytosolic calcium concentrations. got7fsn_ti regulation of cytosolic calcium ion concentration by calcium ion buffering molecular_function owl:Class
GO:0005509 biolink:NamedThing calcium ion binding Binding to a calcium ion (Ca2+). got7fsn_ti calcium ion storage activity molecular_function owl:Class
GO:0010638 biolink:NamedThing positive regulation of organelle organization Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. got7fsn_ti positive regulation of organelle organisation|positive regulation of organelle organization and biogenesis biological_process owl:Class
GO:0042736 biolink:NamedThing NADH kinase activity Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH. got7fsn_ti ATP:NADH 2'-phosphotransferase activity|DPNH kinase activity|reduced diphosphopyridine nucleotide kinase activity|reduced nicotinamide adenine dinucleotide kinase (phosphorylating) RHEA:12260|EC:2.7.1.86|MetaCyc:NADH-KINASE-RXN|KEGG_REACTION:R00105 molecular_function owl:Class
GO:0044854 biolink:NamedThing plasma membrane raft assembly The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft. got7fsn_ti jl 2014-07-23T15:58:16Z biological_process owl:Class
GO:0001765 biolink:NamedThing membrane raft assembly The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes. got7fsn_ti membrane raft formation|lipid raft formation|lipid raft assembly biological_process owl:Class
GO:0061549 biolink:NamedThing sympathetic ganglion development The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. got7fsn_ti sympathetic ganglia development dph 2013-07-10T08:38:01Z biological_process owl:Class
GO:0061548 biolink:NamedThing ganglion development The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure. got7fsn_ti ganglia development|gangliogenesis dph 2013-07-10T08:36:12Z biological_process owl:Class
GO:0047684 biolink:NamedThing arylamine glucosyltransferase activity Catalysis of the reaction: UDP-glucose + an arylamine = UDP + an N-D-glucosylarylamine. got7fsn_ti UDP-glucose:arylamine N-D-glucosyltransferase activity|UDP glucose-arylamine glucosyltransferase activity|UDPglucose:arylamine N-D-glucosyltransferase activity|uridine diphosphoglucose-arylamine glucosyltransferase activity EC:2.4.1.71|MetaCyc:ARYLAMINE-GLUCOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0019412 biolink:NamedThing aerobic respiration, using hydrogen as electron donor The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water. got7fsn_ti hydrogen oxidation MetaCyc:P283-PWY biological_process owl:Class
GO:0015975 biolink:NamedThing energy derivation by oxidation of reduced inorganic compounds The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released. got7fsn_ti chemolithotrophy|chemolithotrophie|lithotrophy Wikipedia:Lithotrophy biological_process owl:Class
GO:0080073 biolink:NamedThing spermidine:coumaroyl CoA N-acyltransferase activity Catalysis of the transfer of a coumaroyl group to a nitrogen atom on the spermidine molecule. got7fsn_ti dhl 2009-04-13T04:16:59Z molecular_function owl:Class
GO:0044160 biolink:NamedThing host thylakoid membrane The pigmented membrane of any host thylakoid. got7fsn_ti jl 2009-08-11T04:17:31Z cellular_component owl:Class
GO:0005143 biolink:NamedThing interleukin-12 receptor binding Binding to an interleukin-12 receptor. got7fsn_ti interleukin-12 receptor ligand|IL-12 molecular_function owl:Class
GO:0050869 biolink:NamedThing negative regulation of B cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation. got7fsn_ti down-regulation of B cell activation|negative regulation of B lymphocyte activation|down regulation of B cell activation|downregulation of B cell activation|negative regulation of B-lymphocyte activation|negative regulation of B-cell activation|inhibition of B cell activation biological_process owl:Class
GO:0060883 biolink:NamedThing regulation of basement membrane disassembly involved in semicircular canal fusion by cell communication Any process that mediates interactions between a cell and its surroundings that modulates of the rate, frequency or extent of basement membrane disassembly involved in semicircular canal fusion. got7fsn_ti regulation of basal lamina disassembly involved in semicircular canal fusion by cell communication dph 2009-08-13T11:31:56Z biological_process owl:Class
GO:0007154 biolink:NamedThing cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti Wikipedia:Cell_signaling biological_process owl:Class
GO:1902407 biolink:NamedThing assembly of actomyosin apparatus involved in mitotic cytokinesis Any assembly of mitotic cytokinetic actomyosin apparatus. got7fsn_ti actomyosin apparatus assembly involved in cytokinesis involved in mitotic cell cycle|formation of actomyosin apparatus involved in cytokinesis involved in mitotic cell cycle|cytokinesis, formation of actomyosin apparatus involved in mitotic cell cycle jl 2013-09-12T12:28:22Z biological_process owl:Class
GO:1902410 biolink:NamedThing mitotic cytokinetic process Any cytokinetic process that is involved in mitotic cell cycle. got7fsn_ti jl 2013-09-12T12:29:36Z biological_process owl:Class
GO:0052879 biolink:NamedThing 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate. got7fsn_ti (8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((7S,8S,9Z,12Z)-5,8-dihydroxy-9,12-octadecadienoate-forming) activity|8-hydroperoxide isomerase activity|linoleate diol synthase activity KEGG_REACTION:R07062|EC:5.4.4.6|MetaCyc:1.13.11.44-RXN|RHEA:25399 molecular_function owl:Class
GO:0050486 biolink:NamedThing intramolecular transferase activity, transferring hydroxy groups Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule. got7fsn_ti EC:5.4.4.- molecular_function owl:Class
GO:0004964 biolink:NamedThing luteinizing hormone receptor activity Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. got7fsn_ti LHR|lutropin-choriogonadotropic hormone receptor|lutropin receptor|LH receptor GO:0004976 molecular_function owl:Class
GO:0044255 biolink:NamedThing cellular lipid metabolic process The chemical reactions and pathways involving lipids, as carried out by individual cells. got7fsn_ti cellular lipid metabolism biological_process owl:Class
GO:0047153 biolink:NamedThing deoxycytidylate 5-hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 5-hydroxymethyldeoxycytidylate. got7fsn_ti dCMP hydroxymethylase activity|deoxycytidylic hydroxymethylase activity|deoxyCMP hydroxymethylase activity|d-cytidine 5'-monophosphate hydroxymethylase activity|deoxycytidylate hydroxymethyltransferase activity|deoxycytidylate hydroxymethylase activity|5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase activity MetaCyc:2.1.2.8-RXN|KEGG_REACTION:R01669|RHEA:11280|EC:2.1.2.8 molecular_function owl:Class
GO:0001737 biolink:NamedThing establishment of imaginal disc-derived wing hair orientation Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction. got7fsn_ti establishment of wing hair orientation biological_process owl:Class
GO:0001736 biolink:NamedThing establishment of planar polarity Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates. got7fsn_ti establishment of planar cell polarity biological_process owl:Class
GO:0007137 biolink:NamedThing meiotic metaphase II The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0051323 biolink:NamedThing metaphase The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Metaphase biological_process owl:Class
GO:0002095 biolink:NamedThing caveolar macromolecular signaling complex A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3). got7fsn_ti caveolar macromolecular signalling complex cellular_component owl:Class
GO:0098510 biolink:NamedThing sensory perception of high humidity The series of events required for an organism to detect high environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti dos 2013-09-25T13:57:27Z biological_process owl:Class
GO:0009960 biolink:NamedThing endosperm development The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo. got7fsn_ti biological_process owl:Class
GO:0007428 biolink:NamedThing primary branching, open tracheal system Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster. got7fsn_ti primary tracheal branching biological_process owl:Class
GO:0060446 biolink:NamedThing branching involved in open tracheal system development The process in which the anatomical structures of branches in the open tracheal system are generated and organized. got7fsn_ti biological_process owl:Class
GO:0006610 biolink:NamedThing ribosomal protein import into nucleus The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus. got7fsn_ti ribosomal protein import into cell nucleus|ribosomal protein transport from cytoplasm to nucleus|ribosomal protein-nucleus import https://github.com/geneontology/go-annotation/issues/1700 Ribosomal protein rpl12 uses a different import pathway, which is why it has a separate GO term. biological_process owl:Class
GO:0006606 biolink:NamedThing protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. got7fsn_ti protein import into cell nucleus|establishment of protein localization to nucleus|protein transport from cytoplasm to nucleus|protein nucleus import biological_process owl:Class
GO:0106228 biolink:NamedThing peptide glutaryltransferase activity Catalysis of the reaction: glutaryl-CoA + L-lysyl-[protein] = CoA + H+ + N6-glutaryl-L-lysyl-[protein]. got7fsn_ti hjd 2019-10-17T18:58:56Z RHEA:18009 molecular_function owl:Class
GO:0019331 biolink:NamedThing anaerobic respiration, using ammonium as electron donor The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2. got7fsn_ti anaerobic ammonium oxidation|anammox MetaCyc:P303-PWY|Wikipedia:Anammox biological_process owl:Class
GO:0009061 biolink:NamedThing anaerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor. got7fsn_ti MetaCyc:ANARESP1-PWY|Wikipedia:Anaerobic_respiration|Wikipedia:Cellular_respiration#Anaerobic_respiration biological_process owl:Class
GO:0047073 biolink:NamedThing 2,4'-dihydroxyacetophenone dioxygenase activity Catalysis of the reaction: 2,4'-dihydroxyacetophenone + O(2) = 4-hydroxybenzoate + formate + 2 H(+). got7fsn_ti 2,4'-dihydroxyacetophenone oxidoreductase (C-C-bond-cleaving)|(4-hydroxybenzoyl)methanol oxygenase activity EC:1.13.11.41|UM-BBD_reactionID:r1410|KEGG_REACTION:R01305|MetaCyc:1.13.11.41-RXN|RHEA:24416 molecular_function owl:Class
GO:0032782 biolink:NamedThing bile acid secretion The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue. got7fsn_ti biological_process owl:Class
GO:0046717 biolink:NamedThing acid secretion The controlled release of acid by a cell or a tissue. got7fsn_ti biological_process owl:Class
GO:0002076 biolink:NamedThing osteoblast development The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone. got7fsn_ti biological_process owl:Class
GO:0016475 biolink:NamedThing detection of nuclear:cytoplasmic ratio The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell. got7fsn_ti interpretation of nuclear:cytoplasmic ratio|sensing of nuclear:cytoplasmic ratio biological_process owl:Class
GO:0009726 biolink:NamedThing detection of endogenous stimulus The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of endogenous stimulus biological_process owl:Class
GO:0007584 biolink:NamedThing response to nutrient Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. got7fsn_ti nutritional response pathway|response to nutrients biological_process owl:Class
GO:0031667 biolink:NamedThing response to nutrient levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. got7fsn_ti biological_process owl:Class
GO:0000716 biolink:NamedThing transcription-coupled nucleotide-excision repair, DNA damage recognition The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. got7fsn_ti pyrimidine-dimer repair, DNA damage recognition biological_process owl:Class
GO:0000715 biolink:NamedThing nucleotide-excision repair, DNA damage recognition The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix. got7fsn_ti pyrimidine-dimer repair, DNA damage recognition biological_process owl:Class
GO:0050447 biolink:NamedThing zeatin 9-aminocarboxyethyltransferase activity Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H(+). got7fsn_ti O3-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity|O-acetyl-L-serine acetate-lyase (adding N(6)-substituted adenine) activity|lupinic acid synthetase activity|lupinic acid synthase activity|O-acetyl-L-serine acetate-lyase (adding N6-substituted adenine)|lupinate synthetase activity|3-O-acetyl-L-serine:zeatin 2-amino-2-carboxyethyltransferase activity|beta-(9-cytokinin)-alanine synthase activity|beta-(9-cytokinin)alanine synthase activity EC:2.5.1.50|MetaCyc:BETA-9-CYTOKININ-ALANINE-SYNTHASE-RXN|RHEA:17333|KEGG_REACTION:R03133 molecular_function owl:Class
GO:0007438 biolink:NamedThing oenocyte development The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments. got7fsn_ti biological_process owl:Class
GO:0050901 biolink:NamedThing leukocyte tethering or rolling Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection). got7fsn_ti https://github.com/geneontology/go-ontology/issues/12276#issuecomment-185260139|https://github.com/geneontology/go-ontology/issues/20174 biological_process owl:Class
GO:0031131 biolink:NamedThing reception of an inductive signal The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change. got7fsn_ti biological_process owl:Class
GO:0031668 biolink:NamedThing cellular response to extracellular stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. got7fsn_ti biological_process owl:Class
GO:0001913 biolink:NamedThing T cell mediated cytotoxicity The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. got7fsn_ti T-lymphocyte mediated cytotoxicity|T cell mediated cell death|T-cell mediated cell death|T-cell mediated cell killing|T cell mediated cell killing|T lymphocyte mediated cytotoxicity|T-cell mediated cytotoxicity|T cell mediated cytolysis|T cell mediated apoptosis|T-cell mediated apoptosis Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. biological_process owl:Class
GO:0036516 biolink:NamedThing chemoattraction of dopaminergic neuron axon The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal. got7fsn_ti chemoattraction of DA axon|chemoattraction of dopaminergic axon bf 2015-12-17T11:23:11Z biological_process owl:Class
GO:0061642 biolink:NamedThing chemoattraction of axon The process in which a neuron growth cone is directed to a specific target site in response to an attractive chemical signal. got7fsn_ti dph 2014-08-29T08:21:24Z biological_process owl:Class
GO:0003138 biolink:NamedThing primary heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. got7fsn_ti FHS specification|first heart field specification tb 2009-09-22T03:47:24Z biological_process owl:Class
GO:0003128 biolink:NamedThing heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop. got7fsn_ti tb 2009-09-22T02:56:05Z biological_process owl:Class
GO:0032451 biolink:NamedThing demethylase activity Catalysis of the removal of a methyl group from a substrate. got7fsn_ti molecular_function owl:Class
GO:0003824 biolink:NamedThing catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. got7fsn_ti enzyme activity Wikipedia:Enzyme molecular_function owl:Class
GO:0045037 biolink:NamedThing protein import into chloroplast stroma The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import. got7fsn_ti protein transport into chloroplast stroma|chloroplast stroma protein import biological_process owl:Class
GO:0045036 biolink:NamedThing protein targeting to chloroplast The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved. got7fsn_ti protein-chloroplast targeting biological_process owl:Class
GO:0072006 biolink:NamedThing nephron development The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. got7fsn_ti nephrogenesis mah 2010-01-25T01:37:16Z biological_process owl:Class
GO:0140315 biolink:NamedThing iron ion sequestering activity The selective interaction of a protein with an iron ion to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell. got7fsn_ti pg 2019-03-28T10:10:33Z molecular_function owl:Class
GO:0005787 biolink:NamedThing signal peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. got7fsn_ti cellular_component owl:Class
GO:0047866 biolink:NamedThing dimethylglycine oxidase activity Catalysis of the reaction: N,N-dimethylglycine + H(2)O + O(2) = formaldehyde + H(2)O(2) + sarcosine. got7fsn_ti N,N-dimethylglycine:oxygen oxidoreductase (demethylating) EC:1.5.3.10|KEGG_REACTION:R01564|MetaCyc:DIMETHYLGLYCINE-OXIDASE-RXN|RHEA:17077 molecular_function owl:Class
GO:0016647 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen. got7fsn_ti EC:1.5.3.- molecular_function owl:Class
GO:0047177 biolink:NamedThing glycerophospholipid arachidonoyl-transferase (CoA-independent) activity Catalysis of the reaction: 1-alkyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-arachidonyl-sn-glycero-3-phosphoethanolamine. got7fsn_ti 1-organyl-2-arachidonoyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent)|1-organyl-2-arachidonyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine arachidonoyltransferase (CoA-independent) EC:2.3.1.147|RHEA:15409|MetaCyc:2.3.1.147-RXN molecular_function owl:Class
GO:0002569 biolink:NamedThing somatic diversification of immune receptors by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene. got7fsn_ti biological_process owl:Class
GO:0009829 biolink:NamedThing cell wall modification involved in fruit ripening The series of events resulting in chemical or structural alterations of existing cell walls that contribute to fruit ripening. got7fsn_ti cell wall modification during ripening biological_process owl:Class
GO:0022412 biolink:NamedThing cellular process involved in reproduction in multicellular organism A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism. got7fsn_ti reproductive cellular process in multicellular organism biological_process owl:Class
GO:0052769 biolink:NamedThing beta-6-sulfate-N-acetylglucosaminidase activity Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative. got7fsn_ti exosulfoglycosidase activity|sulfoglycosidase activity|sulfomucin beta-6-sulfate-N-acetylglucosaminidase activity|beta-6-SO3-N-acetylglucosaminidase activity ai 2011-09-30T12:55:24Z molecular_function owl:Class
GO:0042688 biolink:NamedThing crystal cell differentiation The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. got7fsn_ti biological_process owl:Class
GO:0042386 biolink:NamedThing hemocyte differentiation The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. got7fsn_ti arthropod blood cell differentiation biological_process owl:Class
GO:0003943 biolink:NamedThing N-acetylgalactosamine-4-sulfatase activity Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. got7fsn_ti arylsulfatase B|chondroitinsulfatase|N-acetylgalactosamine-4-sulphatase activity|N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity|acetylgalactosamine 4-sulfatase activity|N-acetylgalactosamine 4-sulfate sulfohydrolase activity Reactome:R-HSA-1606789|Reactome:R-HSA-1793207|Wikipedia:Arylsulfatase_B|Reactome:R-HSA-9036065|Reactome:R-HSA-2282889|EC:3.1.6.12|MetaCyc:3.1.6.12-RXN molecular_function owl:Class
GO:0090561 biolink:NamedThing nuclear migration during mitotic telophase The dynein-driven microtubule based nuclear migration, whereby daughter nuclei are positioned away from the cell division site prior to cytokinesis. got7fsn_ti tb 2014-03-27T15:17:10Z biological_process owl:Class
GO:0052759 biolink:NamedThing coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction. got7fsn_ti coenzyme F420-dependent 2,4,6-trinitrophenol-hydride-Meisenheimer-complex hydride transferase activity 2011-09-28T01:50:17Z UM-BBD_reactionID:r1066|EC:1.3.99.- molecular_function owl:Class
GO:0071564 biolink:NamedThing npBAF complex A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. got7fsn_ti mah 2010-01-20T03:33:42Z cellular_component owl:Class
GO:0030429 biolink:NamedThing kynureninase activity Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine. got7fsn_ti kynurenine hydrolase activity|L-kynurenine hydrolase activity MetaCyc:KYNURENINASE-RXN|EC:3.7.1.3|Reactome:R-HSA-71217|RHEA:16813 molecular_function owl:Class
GO:0004852 biolink:NamedThing uroporphyrinogen-III synthase activity Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III. got7fsn_ti uroporphyrinogen-III cosynthase activity|uroporphyrinogen isomerase activity|URO-synthase activity|hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)|hydroxymethylbilane hydro-lyase (cyclizing) activity|porphobilinogenase activity|uroporphyrinogen-III cosynthetase activity|uroporphyrinogen III cosynthase activity KEGG_REACTION:R03165|RHEA:18965|EC:4.2.1.75|MetaCyc:UROGENIIISYN-RXN|Reactome:R-HSA-189488 molecular_function owl:Class
GO:0030780 biolink:NamedThing 12-hydroxydihydrochelirubine 12-O-methyltransferase activity Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+). got7fsn_ti S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity MetaCyc:2.1.1.120-RXN|EC:2.1.1.120|RHEA:21092|KEGG_REACTION:R04705 molecular_function owl:Class
GO:0071347 biolink:NamedThing cellular response to interleukin-1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. got7fsn_ti cellular response to IL-1 mah 2009-12-11T02:49:17Z biological_process owl:Class
GO:0070555 biolink:NamedThing response to interleukin-1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. got7fsn_ti response to IL-1 biological_process owl:Class
GO:0071847 biolink:NamedThing TNFSF11-mediated signaling pathway A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti RANKL-mediated signaling pathway|TNFSF11-mediated signalling pathway|tumor necrosis factor superfamily member 11-mediated signaling pathway|receptor activator of nuclear factor kappa-B ligand signaling pathway|TNF-related activation-induced cytokine-mediated signaling pathway mah 2010-09-10T02:22:42Z biological_process owl:Class
GO:0033209 biolink:NamedThing tumor necrosis factor-mediated signaling pathway A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti adipocytokine signaling pathway|tumor necrosis factor-mediated signalling pathway|TNF-alpha-mediated signaling pathway|tumor necrosis factor alpha-mediated signaling pathway biological_process owl:Class
GO:0047361 biolink:NamedThing phosphomannan mannosephosphotransferase activity Catalysis of the reaction: phosphomannan(n) + GDP-mannose = phosphomannan(n+1) + GMP. got7fsn_ti GDP-mannose:phosphomannan mannose phosphotransferase activity MetaCyc:2.7.8.9-RXN|EC:2.7.8.9 molecular_function owl:Class
GO:0090464 biolink:NamedThing histidine homeostasis Any process involved in the maintenance of an internal steady state of histidine within an organism or cell. got7fsn_ti tb 2012-09-24T14:22:02Z biological_process owl:Class
GO:0106145 biolink:NamedThing scopoletin 8-hydroxylase activity Catalyzes of the reaction: scopoletin + 2-oxoglutarate+O2=fraxetin +succinate+ CO2). got7fsn_ti hjd 2018-09-07T18:28:16Z RHEA:57848|EC:1.14.11.60 molecular_function owl:Class
GO:0017003 biolink:NamedThing protein-heme linkage The covalent linkage of heme and a protein. got7fsn_ti protein-haem linkage biological_process owl:Class
GO:0017006 biolink:NamedThing protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. got7fsn_ti biological_process owl:Class
GO:1904950 biolink:NamedThing negative regulation of establishment of protein localization Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization. got7fsn_ti down regulation of protein positioning|negative regulation of protein recruitment|down-regulation of protein positioning|negative regulation of establishment of protein localisation|down regulation of establishment of protein localization|downregulation of protein positioning|down regulation of protein recruitment|inhibition of protein positioning|negative regulation of protein positioning|down-regulation of establishment of protein localization|downregulation of establishment of protein localization|inhibition of establishment of protein localisation|down-regulation of establishment of protein localisation|down regulation of establishment of protein localisation|downregulation of establishment of protein localisation|inhibition of protein recruitment|downregulation of protein recruitment|down-regulation of protein recruitment|inhibition of establishment of protein localization mec 2016-02-05T09:59:24Z biological_process owl:Class
GO:0070201 biolink:NamedThing regulation of establishment of protein localization Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location. got7fsn_ti regulation of establishment of protein localisation biological_process owl:Class
GO:0003255 biolink:NamedThing endocardial precursor cell differentiation The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate. got7fsn_ti dph 2009-10-15T12:09:43Z biological_process owl:Class
GO:0010002 biolink:NamedThing cardioblast differentiation The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti cardiomyocyte generation|cardioblast cell differentiation|cardiac precursor cell differentiation biological_process owl:Class
GO:0018520 biolink:NamedThing cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2. got7fsn_ti 4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity|cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating) EC:1.3.1.67|MetaCyc:1.3.1.67-RXN|UM-BBD_reactionID:r0179 molecular_function owl:Class
GO:0072557 biolink:NamedThing IPAF inflammasome complex An inflammasome complex that consists of three components, IPAF, NAIP and caspase-1, and includes among its functions the sensing of flagellin derived from Legionella pneumophila, Salmonella typhimurium, Pseudomonas aeruginosa and Shigella flexneri. got7fsn_ti mah 2011-01-27T12:01:44Z cellular_component owl:Class
GO:0061702 biolink:NamedThing inflammasome complex A cytosolic protein complex that is capable of activating caspase-1. got7fsn_ti dph 2015-05-08T14:30:54Z cellular_component owl:Class
GO:0075284 biolink:NamedThing asexual sporulation resulting in formation of a multicellular or syncytial spore The formation of a multicellular or syncytial spore via septations derived from mitosis. got7fsn_ti biological_process owl:Class
GO:0075283 biolink:NamedThing sporulation resulting in formation of a multicellular or syncytial spore The process whose specific outcome is the progression of a multicellular or syncytial spore via septations over time, from its initiation to the mature structure. got7fsn_ti multicellular or syncytial spore formation by sporulation biological_process owl:Class
GO:0008442 biolink:NamedThing 3-hydroxyisobutyrate dehydrogenase activity Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. got7fsn_ti Reactome:R-HSA-70885|Reactome:R-HSA-508473|EC:1.1.1.31|MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN|RHEA:17681 molecular_function owl:Class
GO:0050437 biolink:NamedThing (-)-endo-fenchol synthase activity Catalysis of the reaction: geranyl diphosphate + H(2)O = (-)-endo-fenchol + diphosphate. got7fsn_ti (-)-endo-fenchol cyclase activity|geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-endo-fenchol-forming]|geranyl pyrophosphate:(-)-endo-fenchol cyclase activity RHEA:20565|EC:4.2.3.10|MetaCyc:4.2.3.10-RXN|KEGG_REACTION:R02004 molecular_function owl:Class
GO:0034726 biolink:NamedThing DNA replication-independent nucleosome disassembly The controlled breakdown of nucleosomes outside the context of DNA replication. got7fsn_ti biological_process owl:Class
GO:0006337 biolink:NamedThing nucleosome disassembly The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. got7fsn_ti biological_process owl:Class
GO:0019426 biolink:NamedThing bisulfite reduction The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite. got7fsn_ti bisulphite reduction MetaCyc:P224-PWY biological_process owl:Class
GO:0019419 biolink:NamedThing sulfate reduction The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. got7fsn_ti sulphate reduction, APS pathway|assimilatory sulfate reduction|sulfate reduction, APS pathway|assimilatory sulphate reduction|sulphate reduction GO:0019421 biological_process owl:Class
GO:0075041 biolink:NamedThing positive regulation of establishment of turgor in appressorium Any process that activates or increases the frequency, rate or extent of turgor formation in the symbiont appressorium. got7fsn_ti biological_process owl:Class
GO:0075018 biolink:NamedThing positive regulation of appressorium formation Any process that activates or increases the frequency, rate or extent of symbiont appressorium formation. got7fsn_ti positive regulation of appressorium formation on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0052519 biolink:NamedThing positive regulation by host of nutrient release from symbiont Any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti upregulation by host of nutrient release from symbiont|up regulation by host of nutrient release from symbiont|up-regulation by host of nutrient release from symbiont|stimulation by host of nutrient release from symbiont|activation by host of nutrient release from symbiont|promotion of nutrient release from symbiont biological_process owl:Class
GO:0052460 biolink:NamedThing modulation by host of nutrient release from symbiont Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0070727 biolink:NamedThing cellular macromolecule localization Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell. got7fsn_ti cellular macromolecule localisation mah 2009-06-16T04:08:29Z biological_process owl:Class
GO:0071207 biolink:NamedThing histone pre-mRNA stem-loop binding Binding to a conserved stem-loop structure found in histone pre-mRNAs. got7fsn_ti mah 2009-11-25T01:25:15Z molecular_function owl:Class
GO:0036002 biolink:NamedThing pre-mRNA binding Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. got7fsn_ti protein-coding primary transcript binding bf 2011-09-16T10:23:37Z molecular_function owl:Class
GO:1990604 biolink:NamedThing IRE1-TRAF2-ASK1 complex A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K). got7fsn_ti ERN1-TRAF2-ASK1 complex bf 2015-01-13T15:03:04Z cellular_component owl:Class
GO:0072715 biolink:NamedThing cellular response to selenite ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus. got7fsn_ti mah 2012-04-19T02:47:50Z biological_process owl:Class
GO:0000830 biolink:NamedThing inositol hexakisphosphate 4-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate. got7fsn_ti molecular_function owl:Class
GO:0000828 biolink:NamedThing inositol hexakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown. got7fsn_ti Reactome:R-HSA-1855216|Reactome:R-HSA-1855207|Reactome:R-HSA-1855227 molecular_function owl:Class
GO:0005315 biolink:NamedThing inorganic phosphate transmembrane transporter activity Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti GO:0005317 molecular_function owl:Class
GO:0015291 biolink:NamedThing secondary active transmembrane transporter activity Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters. got7fsn_ti galactose/glucose (methylgalactoside) porter activity|secondary carrier-type facilitators|active transporter|porter activity|nitrite/nitrate porter activity|electrochemical potential-driven transporter activity|coupled carrier|porters|multidrug endosomal transmembrane transporter activity|heavy metal ion porter activity|ion-gradient-driven energizer activity|energizer of outer membrane receptor-mediated transport activity GO:0015404|GO:0015290|GO:0015353|GO:0015570 TC:2.A|Reactome:R-HSA-199216 molecular_function owl:Class
GO:0044624 biolink:NamedThing envenomation resulting in modulation of cell migration in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of cell migration in the bitten organism. got7fsn_ti envenomation resulting in regulation of cell migration in other organism jl 2012-07-04T05:03:56Z biological_process owl:Class
GO:0007342 biolink:NamedThing fusion of sperm to egg plasma membrane involved in single fertilization The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head. got7fsn_ti sperm-oocyte fusion biological_process owl:Class
GO:0045026 biolink:NamedThing plasma membrane fusion The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell. got7fsn_ti cell-cell fusion|cell fusion GO:0006947 biological_process owl:Class
GO:0038034 biolink:NamedThing signal transduction in absence of ligand A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor. got7fsn_ti addiction receptor signaling pathway|basal signaling|negative signal transduction|signal transduction in absence of agonist|dependence receptor signaling pathway|non-classical signal transduction bf 2011-10-26T02:21:03Z biological_process owl:Class
GO:0098793 biolink:NamedThing presynapse The part of a synapse that is part of the presynaptic cell. got7fsn_ti presynaptic terminal cellular_component owl:Class
GO:0062147 biolink:NamedThing L-lysine 4-chlorinase activity Catalysis of the reaction: 2-oxoglutarate + chloride + H(+) + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate. got7fsn_ti dph 2019-09-02T17:01:46Z RHEA:59884 molecular_function owl:Class
GO:0050498 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated. got7fsn_ti EC:1.14.20.- molecular_function owl:Class
GO:1990109 biolink:NamedThing rejection of pollen from other species The process involved in the rejection of pollen of one species by cells in the stigma of another species. got7fsn_ti unilateral interspecific incompatibility tb 2013-05-29T21:12:09Z biological_process owl:Class
GO:0006223 biolink:NamedThing uracil salvage Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0046107 biolink:NamedThing uracil biosynthetic process The chemical reactions and pathways resulting in the formation of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA. got7fsn_ti uracil synthesis|uracil anabolism|uracil formation|uracil biosynthesis biological_process owl:Class
GO:0042953 biolink:NamedThing lipoprotein transport The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0006810 biolink:NamedThing transport The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein. got7fsn_ti single-organism transport|small molecule transport|solute:solute exchange Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. jl 2012-12-13T16:25:32Z GO:0015460|GO:0015457|GO:0044765 biological_process owl:Class
GO:0051918 biolink:NamedThing negative regulation of fibrinolysis Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. got7fsn_ti down-regulation of fibrinolysis|downregulation of fibrinolysis|down regulation of fibrinolysis|inhibition of fibrinolysis biological_process owl:Class
GO:0030194 biolink:NamedThing positive regulation of blood coagulation Any process that activates or increases the frequency, rate or extent of blood coagulation. got7fsn_ti stimulation of blood coagulation|up regulation of blood coagulation|upregulation of blood coagulation|activation of blood coagulation|up-regulation of blood coagulation biological_process owl:Class
GO:0050005 biolink:NamedThing isohexenylglutaconyl-CoA hydratase activity Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H(2)O. got7fsn_ti isohexenylglutaconyl coenzyme A hydratase activity|3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming]|3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase activity|beta-isohexenylglutaconyl-CoA-hydratase activity|3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase activity KEGG_REACTION:R03493|RHEA:24144|UM-BBD_reactionID:r1167|MetaCyc:ISOHEXENYLGLUTACONYL-COA-HYDRATASE-RXN|EC:4.2.1.57 molecular_function owl:Class
GO:0019384 biolink:NamedThing caprolactam catabolic process The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid. got7fsn_ti caprolactam catabolism|caprolactam breakdown|caprolactam degradation MetaCyc:P621-PWY biological_process owl:Class
GO:0008425 biolink:NamedThing 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. got7fsn_ti coenzyme Q biosynthetic process methyltransferase activity|ubiquinone biosynthetic process methyltransferase activity|coenzyme Q biosynthesis methyltransferase activity|ubiquinone biosynthesis methyltransferase activity|2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity EC:2.1.1.- molecular_function owl:Class
GO:0030580 biolink:NamedThing quinone cofactor methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1). got7fsn_ti molecular_function owl:Class
GO:0021566 biolink:NamedThing hypoglossal nerve development The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. got7fsn_ti cranial nerve XII development|cranial nerve 12 development|CN XII development biological_process owl:Class
GO:0033166 biolink:NamedThing hyaline layer A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms. got7fsn_ti cellular_component owl:Class
GO:0044863 biolink:NamedThing modulation by virus of host cell division Any process where an infecting virus modulates the frequency, rate or extent of the physical partitioning and separation of its host's cell into daughter cells. got7fsn_ti regulation by virus of host cell division jl 2014-08-05T16:30:03Z biological_process owl:Class
GO:0072249 biolink:NamedThing metanephric glomerular visceral epithelial cell development The process whose specific outcome is the progression of a metanephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. got7fsn_ti metanephric podocyte development mah 2010-03-19T03:46:26Z biological_process owl:Class
GO:0072015 biolink:NamedThing glomerular visceral epithelial cell development The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. got7fsn_ti podocyte development mah 2010-01-25T02:12:45Z biological_process owl:Class
GO:0043766 biolink:NamedThing Sep-tRNA:Cys-tRNA synthase activity Catalysis of the reaction: O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate. got7fsn_ti Sep-tRNA:Cys-tRNA synthetase activity|O-phosphoseryl-tRNA:cysteinyl-tRNA synthase activity|SepCysS EC:2.5.1.73|RHEA:25686|MetaCyc:RXN-10719 molecular_function owl:Class
GO:0007164 biolink:NamedThing establishment of tissue polarity Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. got7fsn_ti biological_process owl:Class
GO:0016760 biolink:NamedThing cellulose synthase (UDP-forming) activity Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1). got7fsn_ti UDP-glucose-1,4-beta-glucan glucosyltransferase activity|UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity|beta-1,4-glucosyltransferase activity|1,4-beta-glucan synthase activity|UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity|UDPglucose-cellulose glucosyltransferase activity|beta-1,4-glucan synthase activity|GS-I|beta-1,4-glucan synthetase activity|UDPglucose-beta-glucan glucosyltransferase activity|UDP-glucose-beta-D-glucan glucosyltransferase activity|beta-glucan synthase activity|UDP-glucose-cellulose glucosyltransferase activity|glucan synthase activity|uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity|1,4-beta-D-glucan synthase activity|uridine diphosphoglucose-cellulose glucosyltransferase activity MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN|RHEA:19929|EC:2.4.1.12 molecular_function owl:Class
GO:0016759 biolink:NamedThing cellulose synthase activity Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1). got7fsn_ti cellulose synthetase activity molecular_function owl:Class
GO:0009958 biolink:NamedThing positive gravitropism The orientation of plant parts towards gravity. got7fsn_ti root gravitropism biological_process owl:Class
GO:0009630 biolink:NamedThing gravitropism The orientation of plant parts under the stimulation of gravity. got7fsn_ti geotropism Wikipedia:Gravitropism biological_process owl:Class
GO:0034770 biolink:NamedThing histone H4-K20 methylation The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone. got7fsn_ti histone H4 K20 methylation|histone lysine H4 K20 methylation|histone H4K20me biological_process owl:Class
GO:0034968 biolink:NamedThing histone lysine methylation The modification of a histone by addition of one or more methyl groups to a lysine residue. got7fsn_ti biological_process owl:Class
GO:0047399 biolink:NamedThing glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity Catalysis of the reaction: H2O + 6-(D-glucose-1-phospho)-D-mannosylglycoprotein = D-mannosylglycoprotein + D-glucose-alpha-1-phosphate. got7fsn_ti 6-(D-glucose-1-phospho)-D-mannosylglycoprotein glucose-1-phosphohydrolase activity|alpha-glucose-1-phosphate phosphodiesterase activity EC:3.1.4.51|MetaCyc:3.1.4.51-RXN|RHEA:18045 molecular_function owl:Class
GO:0004454 biolink:NamedThing ketohexokinase activity Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate. got7fsn_ti ATP:D-fructose 1-phosphotransferase activity|hepatic fructokinase activity|ketohexokinase (phosphorylating) Reactome:R-HSA-5656459|RHEA:18145|EC:2.7.1.3|MetaCyc:KETOHEXOKINASE-RXN|Reactome:R-HSA-70333 molecular_function owl:Class
GO:0040005 biolink:NamedThing chitin-based cuticle attachment to epithelium Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster. got7fsn_ti cuticular attachment to epithelium biological_process owl:Class
GO:0022404 biolink:NamedThing molting cycle process A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin. got7fsn_ti biological_process owl:Class
GO:0047975 biolink:NamedThing guanosine phosphorylase activity Catalysis of the reaction: guanosine + phosphate = guanine + D-ribose 1-phosphate. got7fsn_ti guanosine:phosphate alpha-D-ribosyltransferase activity|guanosine:phosphate D-ribosyltransferase activity EC:2.4.2.15|RHEA:13233|MetaCyc:GUANPHOSPHOR-RXN molecular_function owl:Class
GO:0016763 biolink:NamedThing pentosyltransferase activity Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring pentosyl groups https://github.com/geneontology/go-ontology/issues/20486 EC:2.4.2.-|Reactome:R-HSA-112265|Reactome:R-HSA-112266 molecular_function owl:Class
GO:0072169 biolink:NamedThing specification of posterior mesonephric tubule identity The process in which the tubules of the posterior mesonephros acquire their identity. got7fsn_ti mah 2010-02-26T01:54:06Z biological_process owl:Class
GO:0072098 biolink:NamedThing anterior/posterior pattern specification involved in kidney development The developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate. got7fsn_ti kidney anterior/posterior pattern formation|anterior/posterior pattern formation involved in kidney development|kidney anterior/posterior pattern specification mah 2010-02-10T02:06:24Z biological_process owl:Class
GO:1990037 biolink:NamedThing Lewy body core The center portion of a Lewy body. In Parkinson's disease, it contains a matted meshwork of filaments. got7fsn_ti pr 2013-02-08T12:56:59Z NIF_Subcellular:sao6587439252 cellular_component owl:Class
GO:0031220 biolink:NamedThing maltodextrin phosphorylase activity Catalysis of the reaction: maltodextrin = glucose-1-phosphate. got7fsn_ti MetaCyc:RXN-9025|RHEA:29691|MetaCyc:RXN0-5182 molecular_function owl:Class
GO:0004645 biolink:NamedThing 1,4-alpha-oligoglucan phosphorylase activity Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. got7fsn_ti 1,4-alpha-glucan phosphorylase activity|1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity|granulose phosphorylase|polyphosphorylase activity|potato phosphorylase|starch phosphorylase|muscle phosphorylase a and b activity|myophosphorylase|muscle phosphorylase|glucan phosphorylase|amylopectin phosphorylase|alpha-glucan phosphorylase|glucosan phosphorylase|amylophosphorylase activity MetaCyc:RXN-1826|EC:2.4.1.1 molecular_function owl:Class
GO:0061633 biolink:NamedThing transport-coupled glycolytic process through glucose-6-phosphate The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport. got7fsn_ti dph 2014-06-19T09:12:37Z biological_process owl:Class
GO:0061620 biolink:NamedThing glycolytic process through glucose-6-phosphate The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, occurring through a glucose-6-phosphate intermediate, with the concomitant production of a small amount of ATP. got7fsn_ti dph 2014-04-14T09:17:48Z MetaCyc:GLYCOLYSIS biological_process owl:Class
GO:0016899 biolink:NamedThing oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule. got7fsn_ti EC:1.1.3.- molecular_function owl:Class
GO:0034796 biolink:NamedThing adipate-CoA ligase activity Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-. got7fsn_ti UM-BBD_reactionID:r1060 molecular_function owl:Class
GO:0019886 biolink:NamedThing antigen processing and presentation of exogenous peptide antigen via MHC class II The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. got7fsn_ti exogenous peptide antigen processing and presentation via MHC class II|antigen processing, exogenous antigen via major histocompatibility complex class II|antigen presentation, exogenous antigen via MHC class II|antigen presentation, exogenous peptide antigen GO:0048005|GO:0042591 biological_process owl:Class
GO:0002495 biolink:NamedThing antigen processing and presentation of peptide antigen via MHC class II The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. got7fsn_ti peptide antigen processing and presentation via MHC class II biological_process owl:Class
GO:0018860 biolink:NamedThing anthranilate-CoA ligase activity Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA. got7fsn_ti 2-aminobenzoate-CoA ligase activity|anthranilate--CoA ligase activity|2-aminobenzoate coenzyme A ligase activity|anthranilate:CoA ligase (AMP-forming)|anthraniloyl coenzyme A synthetase activity|2-aminobenzoate-coenzyme A ligase activity EC:6.2.1.32|MetaCyc:AMINOBENZCOALIG-RXN|UM-BBD_reactionID:r0341|KEGG_REACTION:R00982|RHEA:10828 molecular_function owl:Class
GO:0017186 biolink:NamedThing peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase. got7fsn_ti peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase|peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase|peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase|2-pyrrolidone-5-carboxylic acid biosynthetic process|2-pyrrolidone-5-carboxylic acid biosynthesis See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'. RESID:AA0031 biological_process owl:Class
GO:0051267 biolink:NamedThing CP2 mannose-ethanolamine phosphotransferase activity Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2. got7fsn_ti CP2 phosphoethanolamine transferase activity|gpi7 activity|CP2 EtN-P transferase activity|CP2 ethanolamine phosphate transferase activity|addition of ethanolamine phosphate to mannose of GPI precursor CP2 molecular_function owl:Class
GO:0051377 biolink:NamedThing mannose-ethanolamine phosphotransferase activity Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. got7fsn_ti phosphoethanolamine transferase activity|EtN-P transferase activity|addition of ethanolamine phosphate to mannose of GPI precursor|ethanolamine phosphate transferase activity Reactome:R-HSA-162798 molecular_function owl:Class
GO:0002941 biolink:NamedThing synoviocyte proliferation The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues. got7fsn_ti hjd 2012-11-16T14:25:45Z biological_process owl:Class
GO:0018362 biolink:NamedThing peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester. got7fsn_ti peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester GO:0019924 RESID:AA0279 biological_process owl:Class
GO:0007275 biolink:NamedThing multicellular organism development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). got7fsn_ti https://github.com/geneontology/go-ontology/issues/21234 Note that this term was 'developmental process'. biological_process owl:Class
GO:0033456 biolink:NamedThing GCG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCG codon. got7fsn_ti alanine tRNA Note that in the standard genetic code, GCG codes for alanine. molecular_function owl:Class
GO:0004495 biolink:NamedThing mevaldate reductase activity Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor. got7fsn_ti molecular_function owl:Class
GO:0051124 biolink:NamedThing synaptic assembly at neuromuscular junction The assembly of a synapse at a neuromuscular junction. got7fsn_ti cholinergic synaptogenesis|synaptic growth at neuromuscular junction biological_process owl:Class
GO:0007416 biolink:NamedThing synapse assembly The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). got7fsn_ti synapse biogenesis|synaptogenesis Wikipedia:Synaptogenesis biological_process owl:Class
GO:0060618 biolink:NamedThing nipple development The progression of the nipple over time, from its formation to the mature structure. The nipple is a part of the mammary gland that protrudes from the surface ectoderm. got7fsn_ti dph 2009-05-18T09:29:38Z biological_process owl:Class
GO:0071929 biolink:NamedThing alpha-tubulin acetylation The addition of an acetyl group to the lysine 40 residue of alpha-tubulin. got7fsn_ti mah 2010-09-28T01:46:38Z biological_process owl:Class
GO:0018393 biolink:NamedThing internal peptidyl-lysine acetylation The addition of an acetyl group to a non-terminal lysine residue in a protein. got7fsn_ti biological_process owl:Class
GO:0009323 biolink:NamedThing ribosomal-protein-alanine N-acetyltransferase complex An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine. got7fsn_ti EC:2.3.1.128 cellular_component owl:Class
GO:0099080 biolink:NamedThing supramolecular complex A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. got7fsn_ti cellular_component owl:Class
GO:0001697 biolink:NamedThing histamine-induced gastric acid secretion The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP. got7fsn_ti biological_process owl:Class
GO:0019684 biolink:NamedThing photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. got7fsn_ti photolysis Wikipedia:Photolysis#Photolysis_in_photosynthesis|MetaCyc:PWY-101 biological_process owl:Class
GO:0035802 biolink:NamedThing adrenal cortex formation The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate). got7fsn_ti adrenal gland cortex formation bf 2011-04-18T10:26:49Z biological_process owl:Class
GO:0071155 biolink:NamedThing G-protein alpha(13)-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(13) subunit of a heterotrimeric G protein. got7fsn_ti Ric-8A G alpha 13 subunit complex mah 2009-11-16T05:01:55Z cellular_component owl:Class
GO:1990584 biolink:NamedThing cardiac Troponin complex A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction. got7fsn_ti cTnC:cTnI:cTnT ame 2014-12-12T16:51:41Z cellular_component owl:Class
GO:0005861 biolink:NamedThing troponin complex A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction. got7fsn_ti cellular_component owl:Class
GO:0016715 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. got7fsn_ti EC:1.14.17.- molecular_function owl:Class
GO:0019037 biolink:NamedThing viral assembly intermediate Specific locations and structures in the virus infected cell involved in assembling new virions. got7fsn_ti cellular_component owl:Class
GO:0062039 biolink:NamedThing biofilm matrix A structure lying external to microbial cells. A biofilm is an aggregate of surface-associated cells, and the biofilm matrix is the envelope of polymeric substances that surrounds the cells. got7fsn_ti dph 2018-05-04T12:49:17Z cellular_component owl:Class
GO:0031012 biolink:NamedThing extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. got7fsn_ti matrisome|proteinaceous extracellular matrix GO:0005578 NIF_Subcellular:nlx_subcell_20090513|Wikipedia:Extracellular_matrix cellular_component owl:Class
GO:0031296 biolink:NamedThing B cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation. got7fsn_ti B cell co-stimulation|B-lymphocyte co-stimulation|B lymphocyte costimulation|B-cell costimulation|B lymphocyte co-stimulation|B-cell co-stimulation|B-lymphocyte costimulation biological_process owl:Class
GO:0031294 biolink:NamedThing lymphocyte costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation. got7fsn_ti lymphocyte co-stimulation biological_process owl:Class
GO:0051365 biolink:NamedThing cellular response to potassium ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions. got7fsn_ti cellular response to potassium ion deprivation|cellular response to potassium starvation|cellular response to K+ ion deprivation|cellular response to K+ ion starvation biological_process owl:Class
GO:1900048 biolink:NamedThing positive regulation of hemostasis Any process that activates or increases the frequency, rate or extent of hemostasis. got7fsn_ti upregulation of hemostasis|up-regulation of hemostasis|activation of hemostasis|up regulation of hemostasis jl 2012-01-19T03:23:45Z biological_process owl:Class
GO:0102322 biolink:NamedThing 2-propylphenol monooxygenase activity Catalysis of the reaction: 2-propylphenol + O2 + NADH + H+ = 3-propylcatechol + H2O + NAD. got7fsn_ti MetaCyc:RXN-13151|RHEA:63524 molecular_function owl:Class
GO:0071274 biolink:NamedThing isoquinoline alkaloid catabolic process The chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. got7fsn_ti isoquinoline alkaloid breakdown|isoquinoline alkaloid catabolism|ipecac alkaloid catabolism|isoquinoline alkaloid degradation mah 2009-12-10T11:17:49Z biological_process owl:Class
GO:0046700 biolink:NamedThing heterocycle catabolic process The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). got7fsn_ti heterocycle catabolism|heterocycle breakdown|heterocycle degradation biological_process owl:Class
GO:0048481 biolink:NamedThing plant ovule development The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed. got7fsn_ti biological_process owl:Class
GO:0005251 biolink:NamedThing delayed rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. got7fsn_ti Reactome:R-HSA-5577050|Reactome:R-HSA-5577237 molecular_function owl:Class
GO:0106318 biolink:NamedThing methane monooxygenase NADPH activity Catalysis of the reaction: methane + NADPH + H+ + O2 = methanol + NADP+ + H2O. got7fsn_ti hjd 2020-09-23T15:12:49Z EC:1.14.13.25|RHEA:13641 molecular_function owl:Class
GO:0072461 biolink:NamedThing response to meiotic recombination checkpoint signaling A process that occurs in response to signals generated as a result of meiotic recombination checkpoint signaling. got7fsn_ti meiotic recombination checkpoint effector process|response to signal involved in meiotic recombination checkpoint mah 2010-12-09T11:37:01Z biological_process owl:Class
GO:0072410 biolink:NamedThing response to meiotic cell cycle checkpoint signaling A process that acts directly to delay or stop progression through the cell cycle in response to signals generated as a result of meiotic cell cycle checkpoint signaling; contributes to a meiotic cell cycle checkpoint. got7fsn_ti response to signal involved in meiotic cell cycle checkpoint|meiotic cell cycle checkpoint effector process mah 2010-12-08T03:48:38Z biological_process owl:Class
GO:0035487 biolink:NamedThing thymine/thymine mispair binding Binding to a double-stranded DNA region containing a T/T mispair. got7fsn_ti T/T mispair binding bf 2010-04-23T10:56:37Z molecular_function owl:Class
GO:0106026 biolink:NamedThing Gly-tRNA(Ala) hydrolase activity Catalysis of the hydrolysis of misacylated Gly-tRNA(Ala). got7fsn_ti hjd 2017-06-16T17:13:33Z molecular_function owl:Class
GO:0002161 biolink:NamedThing aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA. got7fsn_ti aminoacyl-tRNA hydrolysis activity|amino acid proofreading activity hjd 2010-02-12T03:06:56Z molecular_function owl:Class
GO:0048408 biolink:NamedThing epidermal growth factor binding Binding to epidermal growth factor. got7fsn_ti EGF binding molecular_function owl:Class
GO:0042562 biolink:NamedThing hormone binding Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor. got7fsn_ti molecular_function owl:Class
GO:0075321 biolink:NamedThing oomycete sporangium development The process that leads to the development of an oomycete sporangium, a single-celled or many-celled structure that germinates directly to form an infection hypha or differentiates, through specialized cleavage vesicles, into between 10 and 30 zoospores, which are laterally flagellated. got7fsn_ti biological_process owl:Class
GO:0043582 biolink:NamedThing sporangium development The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores. got7fsn_ti sporangia development biological_process owl:Class
GO:0043510 biolink:NamedThing activin B complex A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B). got7fsn_ti Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. GO:0048182 cellular_component owl:Class
GO:0048180 biolink:NamedThing activin complex A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits, inhibin beta-A and inhibin beta-B (sometimes known as activin beta or activin/inhibin beta). There are three forms of activin complex, activin A, which is composed of 2 inhibin beta-A subunits, activin B, which is composed of 2 inhibin beta-B subunits, and activin AB, which is composed of an inhibin beta-A and an inhibin beta-B subunit. got7fsn_ti Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. cellular_component owl:Class
GO:0050163 biolink:NamedThing oxaloacetate tautomerase activity Catalysis of the reaction: oxaloacetate = enol-oxaloacetate. got7fsn_ti oxaloacetate keto-enol tautomerase activity|oxaloacetate keto-enol-isomerase activity|oxalacetic keto-enol isomerase activity KEGG_REACTION:R00363|RHEA:16021|EC:5.3.2.2|MetaCyc:OXALOACETATE-TAUTOMERASE-RXN molecular_function owl:Class
GO:0016862 biolink:NamedThing intramolecular oxidoreductase activity, interconverting keto- and enol-groups Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears. got7fsn_ti intramolecular isomerase activity, interconverting keto- and enol-groups EC:5.3.2.- molecular_function owl:Class
GO:0001025 biolink:NamedThing RNA polymerase III general transcription initiation factor binding Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III. got7fsn_ti RNA polymerase III transcription factor binding krc 2010-08-20T03:26:50Z molecular_function owl:Class
GO:0140296 biolink:NamedThing general transcription initiation factor binding Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation. got7fsn_ti pg 2018-11-28T12:48:06Z molecular_function owl:Class
GO:0005292 biolink:NamedThing high-affinity lysine transmembrane transporter activity Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity lysine transporter activity|high affinity lysine transmembrane transporter activity molecular_function owl:Class
GO:0005287 biolink:NamedThing high-affinity basic amino acid transmembrane transporter activity Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity basic amino acid transmembrane transporter activity|high-affinity basic amino acid transporter activity molecular_function owl:Class
GO:0102788 biolink:NamedThing 4-coumaroyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity Catalysis of the reaction: 4-coumaryl-CoA + pelargonidin 3-O-beta-D-glucoside = pelargonidin 3-O-beta-D-p-coumaroylglucoside + coenzyme A. got7fsn_ti MetaCyc:RXN-7998 molecular_function owl:Class
GO:0002009 biolink:NamedThing morphogenesis of an epithelium The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. got7fsn_ti epithelium morphogenesis biological_process owl:Class
GO:0051567 biolink:NamedThing histone H3-K9 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone. got7fsn_ti histone H3 K9 methylation|histone lysine H3 K9 methylation|histone H3K9me biological_process owl:Class
GO:0061647 biolink:NamedThing histone H3-K9 modification The modification of histone H3 at a lysine in position 9 of the histone. got7fsn_ti dph 2014-10-02T15:07:42Z biological_process owl:Class
GO:0047329 biolink:NamedThing phosphoramidate-hexose phosphotransferase activity Catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3. got7fsn_ti phosphoramidate:hexose 1-phosphotransferase activity|phosphoramidate-hexose transphosphorylase activity|phosphoramidic-hexose transphosphorylase activity RHEA:10972|EC:2.7.1.62|MetaCyc:2.7.1.62-RXN molecular_function owl:Class
GO:0050986 biolink:NamedThing isopeptide cross-linking via N-(L-isoglutamyl)-glycine The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25. got7fsn_ti RESID:AA0360 biological_process owl:Class
GO:0018262 biolink:NamedThing isopeptide cross-linking The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon. got7fsn_ti biological_process owl:Class
GO:0060022 biolink:NamedThing hard palate development The biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes. got7fsn_ti palatum durum development biological_process owl:Class
GO:0005121 biolink:NamedThing Toll binding Binding to a Toll protein, a transmembrane receptor. got7fsn_ti Toll ligand|Tl binding|Toll receptor binding molecular_function owl:Class
GO:0106110 biolink:NamedThing vomitoxin biosynthetic process The chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats. got7fsn_ti vomitoxin formation|vomitoxin anabolism|deoxynivalenol biosynthetic process|vomitoxin biosynthesis|vomitoxin synthesis|DON biosynthetic process hjd 2018-04-16T19:06:06Z biological_process owl:Class
GO:0043386 biolink:NamedThing mycotoxin biosynthetic process The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus. got7fsn_ti mycotoxin biosynthesis|mycotoxin formation|mycotoxin synthesis|mycotoxin anabolism biological_process owl:Class
GO:0007308 biolink:NamedThing oocyte construction The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte arrangement GO:0048110 biological_process owl:Class
GO:0070925 biolink:NamedThing organelle assembly The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. got7fsn_ti mah 2009-09-15T03:00:51Z biological_process owl:Class
GO:0034955 biolink:NamedThing 2,3-dihydroxydiphenyl ether dioxygenase activity Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol. got7fsn_ti UM-BBD_reactionID:r1451|EC:1.13.11.- molecular_function owl:Class
GO:0034084 biolink:NamedThing steryl deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from an acetylated sterol. got7fsn_ti sterol deacetylase activity molecular_function owl:Class
GO:0019213 biolink:NamedThing deacetylase activity Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. got7fsn_ti Reactome:R-HSA-5689000 molecular_function owl:Class
GO:0001941 biolink:NamedThing postsynaptic membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). got7fsn_ti postsynaptic membrane organisation|post-synaptic membrane organization biological_process owl:Class
GO:0004413 biolink:NamedThing homoserine kinase activity Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+). got7fsn_ti homoserine kinase (phosphorylating)|ATP:L-homoserine O-phosphotransferase activity|HSK RHEA:13985|EC:2.7.1.39|MetaCyc:HOMOSERKIN-RXN|KEGG_REACTION:R01771 molecular_function owl:Class
GO:0007051 biolink:NamedThing spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. got7fsn_ti spindle organization and biogenesis|spindle stabilization|spindle organisation GO:0043146 biological_process owl:Class
GO:0047890 biolink:NamedThing flavanone 4-reductase activity Catalysis of the reaction: (2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH. got7fsn_ti flavonone 4-reductase activity|(2S)-flavan-4-ol:NADP+ 4-oxidoreductase activity EC:1.1.1.234|MetaCyc:FLAVANONE-4-REDUCTASE-RXN|RHEA:11228 molecular_function owl:Class
GO:0000121 biolink:NamedThing glycerol-1-phosphatase activity Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate. got7fsn_ti glycerol-1-phosphate phosphohydrolase activity|alpha-glycerophosphatase activity|glycerol 3-phosphatase activity|alpha-glycerol phosphatase activity|glycerol-3-phosphate phosphatase activity|glycerol 3-phosphate phosphohydrolase activity RHEA:11476|MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN|EC:3.1.3.21 molecular_function owl:Class
GO:0044340 biolink:NamedThing canonical Wnt signaling pathway involved in regulation of cell proliferation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation. got7fsn_ti canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|canonical Wnt receptor signalling pathway involved in regulation of cell proliferation|canonical Wnt-activated signaling pathway involved in regulation of cell proliferation jl 2010-08-20T03:57:25Z biological_process owl:Class
GO:0034620 biolink:NamedThing cellular response to unfolded protein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. got7fsn_ti heat shock protein activity Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to the signaling pathways that respond to the presence of unfolded proteins in the ER. biological_process owl:Class
GO:0006986 biolink:NamedThing response to unfolded protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. got7fsn_ti heat shock protein activity Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. biological_process owl:Class
GO:0007311 biolink:NamedThing maternal specification of dorsal/ventral axis, oocyte, germ-line encoded Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster. got7fsn_ti maternal specification of dorsal-ventral axis, oocyte, germ-line encoded|maternal determination of dorsal/ventral axis, oocyte, germ-line encoded|maternal specification of dorsoventral axis, oocyte, germ-line encoded GO:0048124 biological_process owl:Class
GO:1901360 biolink:NamedThing organic cyclic compound metabolic process The chemical reactions and pathways involving organic cyclic compound. got7fsn_ti organic cyclic compound metabolism bf 2012-09-14T09:03:51Z biological_process owl:Class
GO:0071704 biolink:NamedThing organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. got7fsn_ti organic molecular entity metabolic process|organic substance metabolism|organic molecular entity metabolism mah 2010-03-08T03:32:18Z biological_process owl:Class
GO:0030539 biolink:NamedThing male genitalia development The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure. got7fsn_ti male genital development biological_process owl:Class
GO:0030651 biolink:NamedThing peptide antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity. got7fsn_ti peptide antibiotic anabolism|peptide antibiotic synthesis|peptide antibiotic formation|peptide antibiotic biosynthesis biological_process owl:Class
GO:0043043 biolink:NamedThing peptide biosynthetic process The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. got7fsn_ti peptide anabolism|peptide synthesis|peptide formation|peptide biosynthesis biological_process owl:Class
GO:0003935 biolink:NamedThing GTP cyclohydrolase II activity Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+). got7fsn_ti GTP 7,8-8,9-dihydrolase (diphosphate-forming)|GTP-8-formylhydrolase activity|guanosine triphosphate cyclohydrolase II EC:3.5.4.25|RHEA:23704|MetaCyc:GTP-CYCLOHYDRO-II-RXN|KEGG_REACTION:R00425 molecular_function owl:Class
GO:0003933 biolink:NamedThing GTP cyclohydrolase activity Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. got7fsn_ti molecular_function owl:Class
GO:0034217 biolink:NamedThing ascospore wall chitin biosynthetic process The chemical reactions and pathways resulting in the formation of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. got7fsn_ti ascospore wall chitin synthesis|ascospore wall chitin anabolism|ascospore wall chitin formation|ascospore wall chitin biosynthesis biological_process owl:Class
GO:0044106 biolink:NamedThing cellular amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. got7fsn_ti jl 2009-07-15T11:55:44Z biological_process owl:Class
GO:0034579 biolink:NamedThing (1-methylpentyl)succinate synthase activity Catalysis of the reaction: fumarate + n-hexane = (1-methylpentyl)succinate. got7fsn_ti UM-BBD_reactionID:r0920 molecular_function owl:Class
GO:0009100 biolink:NamedThing glycoprotein metabolic process The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. got7fsn_ti glycoprotein metabolism biological_process owl:Class
GO:0050243 biolink:NamedThing pyruvate dehydrogenase (NADP+) activity Catalysis of the reaction: CoA + NADP(+) + pyruvate = acetyl-CoA + CO(2) + NADPH. got7fsn_ti pyruvate:NADP+ oxidoreductase activity|pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)|pyruvate:NADP(+) oxidoreductase activity RHEA:17425|EC:1.2.1.51|MetaCyc:PYRUVATE-DEHYDROGENASE-NADP%2b-RXN|KEGG_REACTION:R00210 molecular_function owl:Class
GO:0034603 biolink:NamedThing pyruvate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: pyruvate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. got7fsn_ti molecular_function owl:Class
GO:0061568 biolink:NamedThing GDP phosphorylation The process of introducing a phosphate group into GDP, guanosine diphosphate, to produce GTP. got7fsn_ti dph 2013-08-01T12:57:12Z biological_process owl:Class
GO:0072697 biolink:NamedThing protein localization to cell cortex A process in which a protein is transported to, or maintained in, the cell cortex. got7fsn_ti protein localisation to cell cortex mah 2012-04-11T01:16:33Z biological_process owl:Class
GO:0097489 biolink:NamedThing multivesicular body, internal vesicle lumen The volume enclosed by the membrane of the multivesicular body internal vesicle. got7fsn_ti pr 2013-07-08T20:38:36Z cellular_component owl:Class
GO:0031983 biolink:NamedThing vesicle lumen The volume enclosed by the membrane or protein that forms a vesicle. got7fsn_ti NIF_Subcellular:sao797538226 cellular_component owl:Class
GO:0016423 biolink:NamedThing tRNA (guanine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. got7fsn_ti tRNA (guanosine) methyltransferase activity GO:0016424 molecular_function owl:Class
GO:0008175 biolink:NamedThing tRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. got7fsn_ti Reactome:R-HSA-6786500|Reactome:R-HSA-6786567|Reactome:R-HSA-6783473|Reactome:R-HSA-6782881|Reactome:R-HSA-6782879|Reactome:R-HSA-6782890 molecular_function owl:Class
GO:0048629 biolink:NamedThing trichome patterning The regionalization process of establishing the non-random spatial arrangement of trichomes on the surface and margin of a leaf. Process involves signaling between adjacent epidermal cells that results in differentiation of some epidermal cells into trichomes. got7fsn_ti trichome spacing|trichome pattern biosynthesis|trichome pattern formation|trichome distribution|trichome pattern specification biological_process owl:Class
GO:0045168 biolink:NamedThing cell-cell signaling involved in cell fate commitment Signaling at long or short range between cells that results in the commitment of a cell to a certain fate. got7fsn_ti cell-cell signaling during in cell fate commitment|cell fate commitment, cell-cell signaling|cell fate commitment, cell-cell signalling|cell-cell signaling resulting in cell fate commitment|cell-cell signalling during cell fate commitment|cell-cell signalling involved in cell fate specification|cell-cell signalling resulting in cell fate commitment biological_process owl:Class
GO:0003218 biolink:NamedThing cardiac left ventricle formation The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts. got7fsn_ti dph 2009-10-13T09:54:33Z biological_process owl:Class
GO:0008454 biolink:NamedThing alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R. got7fsn_ti N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity|uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity|alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity|beta-acetylglucosaminyltransferase IV activity|alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyltransferase IV activity|UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity|uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV|GnTIV activity Reactome:R-HSA-975903|EC:2.4.1.145|MetaCyc:2.4.1.145-RXN|Reactome:R-HSA-9696980|RHEA:16057 molecular_function owl:Class
GO:0018162 biolink:NamedThing peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine. got7fsn_ti RESID:AA0253 biological_process owl:Class
GO:0071836 biolink:NamedThing nectar secretion The controlled release of a nectar by a cell or a tissue. Nectar is a fluid secreted by many angiosperms to promote pollination by providing a reward to pollinators. Nectar may also deter certain organisms from visiting or play other biological roles. Nectar is a complex solution that may include the following types of compounds: sugars, amino acids, organic acids, alkaloids, flavonoids, glycosides, vitamins, phenolics, metal ions, oils, free fatty acids, and proteins. got7fsn_ti nectar production mah 2010-09-09T01:06:04Z biological_process owl:Class
GO:0046903 biolink:NamedThing secretion The controlled release of a substance by a cell or a tissue. got7fsn_ti biological_process owl:Class
GO:0018495 biolink:NamedThing 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA. got7fsn_ti UM-BBD_reactionID:r0192 molecular_function owl:Class
GO:0051801 biolink:NamedThing cytolysis in other organism involved in symbiotic interaction The killing by an organism of a cell in a second organism by means of the rupture of cell membranes and the loss of cytoplasm, where the two organisms are in a symbiotic interaction. got7fsn_ti cytolysis of cells in other organism during symbiotic interaction|cytolysis of cells in other organism involved in symbiotic interaction biological_process owl:Class
GO:0051715 biolink:NamedThing cytolysis in other organism The killing by an organism of a cell in another organism by means of the rupture of cell membranes and the loss of cytoplasm. got7fsn_ti cytolysis of cells of another organism|cytolysis of cells of another, non-host, organism|cytolysis of cells of competing organism GO:0001901 biological_process owl:Class
GO:0047598 biolink:NamedThing 7-dehydrocholesterol reductase activity Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+. got7fsn_ti sterol delta7-reductase activity|cholesterol:NADP+ delta7-oxidoreductase activity|sterol Delta(7)-reductase activity|7-DHC reductase activity Reactome:R-HSA-6807055|Reactome:R-HSA-196402|RHEA:23984|EC:1.3.1.21|MetaCyc:RXN66-323 molecular_function owl:Class
GO:0004540 biolink:NamedThing ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. got7fsn_ti molecular_function owl:Class
GO:0030195 biolink:NamedThing negative regulation of blood coagulation Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. got7fsn_ti down-regulation of blood coagulation|inhibition of blood coagulation|down regulation of blood coagulation|downregulation of blood coagulation biological_process owl:Class
GO:0050819 biolink:NamedThing negative regulation of coagulation Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. got7fsn_ti downregulation of coagulation|anticoagulant activity|down regulation of coagulation|inhibition of coagulation|negative regulation of clotting|down-regulation of coagulation biological_process owl:Class
GO:0043414 biolink:NamedThing macromolecule methylation The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. got7fsn_ti biological_process owl:Class
GO:0043412 biolink:NamedThing macromolecule modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. got7fsn_ti biological_process owl:Class
GO:0002252 biolink:NamedThing immune effector process Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18737 biological_process owl:Class
GO:0019128 biolink:NamedThing peptidyl-tryptophan racemization The racemization of peptidyl-tryptophan. got7fsn_ti GO:0018092|GO:0018374 RESID:AA0198 biological_process owl:Class
GO:0018085 biolink:NamedThing peptidyl-L-amino acid racemization The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid. got7fsn_ti biological_process owl:Class
GO:0004317 biolink:NamedThing 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O. got7fsn_ti 3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity|beta-hydroxypalmityl-ACP dehydrase activity|D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity|(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)|beta-hydroxypalmitoyl thioester dehydratase activity|(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity|3-hydroxypalmitoyl-ACP dehydratase activity|3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity|D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity|(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity RHEA:41908|KEGG_REACTION:R04462|EC:4.2.1.59|MetaCyc:4.2.1.61-RXN molecular_function owl:Class
GO:0019171 biolink:NamedThing 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]. got7fsn_ti 3-hydroxyacyl-[acyl-carrier protein] dehydratase activity|3-hydroxyacyl-ACP dehydratase activity RHEA:13097|EC:4.2.1.59|MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN molecular_function owl:Class
GO:0044301 biolink:NamedThing climbing fiber The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber. got7fsn_ti climbing fibre jl 2010-02-05T11:20:56Z NIF_Subcellular:nlx_subcell_20090203 cellular_component owl:Class
GO:0030424 biolink:NamedThing axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. got7fsn_ti Wikipedia:Axon|NIF_Subcellular:sao1770195789 cellular_component owl:Class
GO:1903041 biolink:NamedThing regulation of chondrocyte hypertrophy Any process that modulates the frequency, rate or extent of chondrocyte hypertrophy. got7fsn_ti mr 2014-05-20T21:23:13Z biological_process owl:Class
GO:0030433 biolink:NamedThing ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. got7fsn_ti endoplasmic reticulum-associated ubiqutin-dependent protein catabolism|ER-associated ubiquitin-dependent protein catabolism|ERAD|ER-associated ubiquitin-dependent protein breakdown|ER-associated ubiquitin-dependent protein degradation|ER-associated ubiquitin-dependent protein catabolic process|ubiquitin-dependent proteasomal protein catabolism of ER proteins|endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. biological_process owl:Class
GO:0043161 biolink:NamedThing proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. got7fsn_ti proteasome pathway|proteasomal ubiquitin-dependent protein breakdown|proteasomal processing|proteasomal ubiquitin-dependent protein catabolism|proteasomal ubiquitin-dependent protein catabolic process|proteasomal ubiquitin-dependent protein degradation|proteasomal pathway biological_process owl:Class
GO:0000150 biolink:NamedThing DNA strand exchange activity Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. got7fsn_ti strand transferase|strand exchange activity|recombinase activity|RecA-family recombinase activity https://github.com/geneontology/go-ontology/issues/20964 Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. Reactome:R-HSA-912458 molecular_function owl:Class
GO:0009941 biolink:NamedThing chloroplast envelope The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. got7fsn_ti cellular_component owl:Class
GO:0009526 biolink:NamedThing plastid envelope The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space. got7fsn_ti cellular_component owl:Class
GO:0021828 biolink:NamedThing gonadotrophin-releasing hormone neuronal migration to the hypothalamus The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus. got7fsn_ti gonadotropin-releasing hormone neuronal migration to the hypothalamus GO:0021857 biological_process owl:Class
GO:0042321 biolink:NamedThing negative regulation of circadian sleep/wake cycle, sleep Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. got7fsn_ti negative regulation of sleep|inhibition of circadian sleep/wake cycle, sleep|downregulation of circadian sleep/wake cycle, sleep|down-regulation of circadian sleep/wake cycle, sleep|down regulation of circadian sleep/wake cycle, sleep biological_process owl:Class
GO:0045187 biolink:NamedThing regulation of circadian sleep/wake cycle, sleep Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals. got7fsn_ti regulation of sleep biological_process owl:Class
GO:0061928 biolink:NamedThing glutathione specific gamma-glutamylcyclotransferase activity Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine. got7fsn_ti dph 2017-08-29T14:55:30Z EC:4.3.2.7|RHEA:47724 molecular_function owl:Class
GO:0032586 biolink:NamedThing protein storage vacuole membrane The lipid bilayer surrounding a protein storage vacuole. got7fsn_ti cellular_component owl:Class
GO:0009705 biolink:NamedThing plant-type vacuole membrane The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana. got7fsn_ti membrane of vacuole with cell cycle-independent morphology|tonoplast|vacuolar membrane cellular_component owl:Class
GO:1901568 biolink:NamedThing fatty acid derivative metabolic process The chemical reactions and pathways involving fatty acid derivative. got7fsn_ti fatty acid derivative metabolism pr 2012-11-04T17:13:36Z biological_process owl:Class
GO:1902406 biolink:NamedThing mitotic actomyosin contractile ring maintenance Any actomyosin contractile ring maintenance that is involved in mitotic cell cycle. got7fsn_ti cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle involved in mitotic cell cycle|contractile ring maintenance involved in cell cycle cytokinesis involved in mitotic cell cycle jl 2013-09-12T12:28:14Z biological_process owl:Class
GO:0102663 biolink:NamedThing gibberellin A34,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A34 + 2-oxoglutarate + O2 <=> H+ + gibberellin A34-catabolite + succinate + carbon dioxide + H2O. got7fsn_ti MetaCyc:RXN-292 molecular_function owl:Class
GO:0047307 biolink:NamedThing diaminobutyrate-pyruvate transaminase activity Catalysis of the reaction: L-2,4-diaminobutyrate + pyruvate = L-alanine + L-aspartate 4-semialdehyde. got7fsn_ti diaminobutyrate--pyruvate aminotransferase activity|diaminobutyrate-pyruvate aminotransferase activity|L-2,4-diaminobutanoate:pyruvate aminotransferase activity|L-diaminobutyric acid transaminase activity KEGG_REACTION:R02293|RHEA:12380|EC:2.6.1.46|MetaCyc:2.6.1.46-RXN molecular_function owl:Class
GO:0047673 biolink:NamedThing anthranilate N-malonyltransferase activity Catalysis of the reaction: anthranilate + malonyl-CoA = N-malonylanthranilate + CoA. got7fsn_ti malonyl-CoA:anthranilate N-malonyltransferase activity KEGG_REACTION:R00989|RHEA:17557|MetaCyc:ANTHRANILATE-N-MALONYLTRANSFERASE-RXN|EC:2.3.1.113 molecular_function owl:Class
GO:0050735 biolink:NamedThing N-malonyltransferase activity Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0021710 biolink:NamedThing cerebellar stellate cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0021533 biolink:NamedThing cell differentiation in hindbrain The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0008467 biolink:NamedThing [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. got7fsn_ti heparin-glucosamine 3-O-sulphotransferase activity|isoform/isozyme 1 (3-OST-1, HS3ST1)|heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity|heparin-glucosamine 3-O-sulfotransferase activity|3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase|3-OST-1 activity|glucosaminyl 3-O-sulfotransferase activity|3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity Reactome:R-HSA-2076611|MetaCyc:2.8.2.23-RXN|EC:2.8.2.23|Reactome:R-HSA-2076383 molecular_function owl:Class
GO:0015398 biolink:NamedThing high-affinity secondary active ammonium transmembrane transporter activity Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity secondary active ammonium transmembrane transporter activity molecular_function owl:Class
GO:0004635 biolink:NamedThing phosphoribosyl-AMP cyclohydrolase activity Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide. got7fsn_ti PRAMP-cyclohydrolase activity|phosphoribosyladenosine monophosphate cyclohydrolase activity|1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity KEGG_REACTION:R04037|RHEA:20049|EC:3.5.4.19|MetaCyc:HISTCYCLOHYD-RXN molecular_function owl:Class
GO:0019238 biolink:NamedThing cyclohydrolase activity Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring. got7fsn_ti molecular_function owl:Class
GO:0050982 biolink:NamedThing detection of mechanical stimulus The series of events by which a mechanical stimulus is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0018592 biolink:NamedThing 4-nitrocatechol 4-monooxygenase activity Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol. got7fsn_ti UM-BBD_reactionID:r0231|EC:1.14.13.166 molecular_function owl:Class
GO:0070626 biolink:NamedThing (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Catalysis of the reaction: (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. got7fsn_ti adenylosuccinate lyase activity|adenylosuccinase activity|succino AMP-lyase activity mah 2009-05-01T04:13:49Z EC:4.3.2.2|KEGG_REACTION:R04559|MetaCyc:AICARSYN-RXN|RHEA:23920 molecular_function owl:Class
GO:0042719 biolink:NamedThing mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. got7fsn_ti Tim9-Tim10 complex cellular_component owl:Class
GO:0030348 biolink:NamedThing syntaxin-3 binding Binding to a syntaxin-3 SNAP receptor. got7fsn_ti molecular_function owl:Class
GO:0019905 biolink:NamedThing syntaxin binding Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. got7fsn_ti syntaxin-5 binding|syntaxin-2 binding|syntaxin-6 binding|syntaxin-13 binding GO:0030349|GO:0030347|GO:0051535|GO:0050430 molecular_function owl:Class
GO:0098921 biolink:NamedThing retrograde trans-synaptic signaling by endocannabinoid Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand. got7fsn_ti biological_process owl:Class
GO:0060617 biolink:NamedThing positive regulation of mammary placode formation by mesenchymal-epithelial signaling Any process that initiates the formation of a mammary placode through a mechanism that mediates the transfer of information from a mesenchymal cell to an epithelial cell resulting in the epithelial cell adopting the identity of a cell of the mammary placode. got7fsn_ti positive regulation of mammary placode formation by mesenchymal-epithelial signalling dph 2009-05-18T09:16:07Z biological_process owl:Class
GO:0060638 biolink:NamedThing mesenchymal-epithelial cell signaling Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted. got7fsn_ti mesenchymal-epithelial cell signalling dph 2009-05-19T03:59:05Z biological_process owl:Class
GO:1900126 biolink:NamedThing negative regulation of hyaluronan biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process. got7fsn_ti downregulation of hyaluronan anabolism|negative regulation of hyaluronan anabolism|inhibition of hyaluronan biosynthetic process|down-regulation of hyaluronan biosynthetic process|down-regulation of hyaluronan anabolism|down regulation of hyaluronan anabolism|negative regulation of hyaluronan synthesis|down regulation of hyaluronan synthesis|downregulation of hyaluronan biosynthesis|inhibition of hyaluronan anabolism|inhibition of hyaluronan formation|down regulation of hyaluronan formation|down-regulation of hyaluronan biosynthesis|inhibition of hyaluronan synthesis|downregulation of hyaluronan formation|negative regulation of hyaluronan formation|down-regulation of hyaluronan synthesis|inhibition of hyaluronan biosynthesis|down regulation of hyaluronan biosynthetic process|negative regulation of hyaluronan biosynthesis|downregulation of hyaluronan synthesis|down regulation of hyaluronan biosynthesis|downregulation of hyaluronan biosynthetic process|down-regulation of hyaluronan formation yaf 2012-02-23T01:09:29Z biological_process owl:Class
GO:0045912 biolink:NamedThing negative regulation of carbohydrate metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. got7fsn_ti inhibition of carbohydrate metabolic process|down-regulation of carbohydrate metabolic process|down regulation of carbohydrate metabolic process|negative regulation of carbohydrate metabolism|downregulation of carbohydrate metabolic process biological_process owl:Class
GO:0103002 biolink:NamedThing 16-hydroxypalmitate dehydrogenase activity Catalysis of the reaction: 16-hydroxypalmitate + NADP <=> H+ + 16-oxo-palmitate + NADPH. got7fsn_ti MetaCyc:RXN-9802 molecular_function owl:Class
GO:0050360 biolink:NamedThing tryptophan 2'-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3. got7fsn_ti tryptophan side chain oxidase activity|tryptophan side chain oxidase II|tryptophan side chain oxidase type I|TSO I|tryptophan side-chain oxidase activity|L-tryptophan:oxygen 2'-oxidoreductase (side-chain-cleaving)|indole-3-alkane alpha-hydroxylase activity|TSO activity|indolyl-3-alkan alpha-hydroxylase activity|tryptophan side-chain alpha,beta-oxidase activity|TSO II EC:1.13.99.3|RHEA:22620|MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN molecular_function owl:Class
GO:0006523 biolink:NamedThing alanine biosynthetic process The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid. got7fsn_ti alanine anabolism|alanine biosynthesis|alanine synthesis|alanine formation biological_process owl:Class
GO:0009079 biolink:NamedThing pyruvate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine. got7fsn_ti pyruvate family amino acid synthesis|pyruvate family amino acid formation|pyruvate family amino acid anabolism|pyruvate family amino acid biosynthesis biological_process owl:Class
GO:0043236 biolink:NamedThing laminin binding Binding to a laminin, a major glycoprotein constituent of the basement membrane of cells. got7fsn_ti laminin-4 binding|laminin-2 binding GO:0043238|GO:0043239 molecular_function owl:Class
GO:0104004 biolink:NamedThing cellular response to environmental stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an environmental stimulus. got7fsn_ti dos 2017-02-17T16:02:42Z biological_process owl:Class
GO:0051716 biolink:NamedThing cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0031493 biolink:NamedThing nucleosomal histone binding Binding to a histone that is assembled into a nucleosome. got7fsn_ti molecular_function owl:Class
GO:0031491 biolink:NamedThing nucleosome binding Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. got7fsn_ti molecular_function owl:Class
GO:0050911 biolink:NamedThing detection of chemical stimulus involved in sensory perception of smell The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. got7fsn_ti perception of smell, detection of chemical stimulus|perception of smell, sensory transduction of chemical stimulus|sensory detection of smell|sensory transduction of scent|sensory transduction of smell|sensory transduction of chemical stimulus during perception of smell|perception of smell, sensory detection of chemical stimulus|sensory detection of scent|sensory detection of chemical stimulus during perception of smell biological_process owl:Class
GO:0050907 biolink:NamedThing detection of chemical stimulus involved in sensory perception The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception. got7fsn_ti sensory transduction of chemical stimulus during sensory perception|sensory detection of chemical stimulus|sensory detection of chemical stimulus during sensory perception|sensory perception, sensory transduction of chemical stimulus|sensory transduction of chemical stimulus|sensory perception, sensory detection of chemical stimulus biological_process owl:Class
GO:0051224 biolink:NamedThing negative regulation of protein transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti down-regulation of protein transport|down regulation of protein transport|downregulation of protein transport|inhibition of protein transport biological_process owl:Class
GO:0033058 biolink:NamedThing directional locomotion Self-propelled movement of a cell or organism from one location to another along an axis. got7fsn_ti biological_process owl:Class
GO:0006789 biolink:NamedThing bilirubin conjugation The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin. got7fsn_ti biological_process owl:Class
GO:0006787 biolink:NamedThing porphyrin-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. got7fsn_ti porphyrin catabolism|porphyrin catabolic process|porphyrin breakdown|porphyrin degradation biological_process owl:Class
GO:0042337 biolink:NamedThing cuticle development involved in chitin-based cuticle molting cycle The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster. got7fsn_ti cuticle anabolism during molting|cuticle biosynthetic process during molting|cuticle formation during molting|cuticle synthesis during molting|chitin-based cuticle development during molting biological_process owl:Class
GO:0040003 biolink:NamedThing chitin-based cuticle development Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster. got7fsn_ti chitin-based cuticle synthesis|chitin-based cuticle formation|chitin-based cuticle biosynthetic process|chitin-based cuticle anabolism biological_process owl:Class
GO:0120112 biolink:NamedThing UDP-glucose transmembrane transport into endoplasmic reticulum The directed movement of UDP-glucose from cytosol to endoplasmic reticulum. got7fsn_ti krc 2017-11-02T15:56:51Z biological_process owl:Class
GO:0015786 biolink:NamedThing UDP-glucose transmembrane transport The process in which UDP-glucose is transported across a membrane. got7fsn_ti biological_process owl:Class
GO:0050952 biolink:NamedThing sensory perception of electrical stimulus The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti biological_process owl:Class
GO:0031598 biolink:NamedThing nuclear proteasome regulatory particle The regulatory subcomplex of a proteasome located in the nucleus of a cell. got7fsn_ti cellular_component owl:Class
GO:0043678 biolink:NamedThing intine The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm. got7fsn_ti Note that the intine is not acetolysis resistant and is therefore absent in conventionally prepared palynological material. cellular_component owl:Class
GO:0032869 biolink:NamedThing cellular response to insulin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. got7fsn_ti biological_process owl:Class
GO:0032868 biolink:NamedThing response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. got7fsn_ti response to insulin stimulus biological_process owl:Class
GO:0090684 biolink:NamedThing contact chemoreceptor activity A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception. got7fsn_ti contact chemosensation receptor activity tb 2016-05-20T15:53:01Z molecular_function owl:Class
GO:0008527 biolink:NamedThing taste receptor activity Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. got7fsn_ti gustatory receptor molecular_function owl:Class
GO:0052867 biolink:NamedThing phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate. got7fsn_ti triphosphoinositide phosphatase activity|phosphatidylinositol 1,4,5-trisphosphate phosphatase activity|triphosphoinositide phosphomonoesterase activity|PtdIns(1,4,5)P(3) phosphatase activity|phosphatidyl-myo-inositol-1,4,5-trisphosphate phosphatase activity|PtdIns(1,4,5)P3 phosphatase activity|phosphatidylinositol-trisphosphatase activity 2012-01-11T12:07:50Z molecular_function owl:Class
GO:0034595 biolink:NamedThing phosphatidylinositol phosphate 5-phosphatase activity Catalysis of the removal of the 5-phosphate group of a phosphatidylinositol phosphate. got7fsn_ti polyphosphoinositol lipid 5-phosphatase activity|phosphoinositide 5-phosphatase activity molecular_function owl:Class
GO:0045058 biolink:NamedThing T cell selection The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation. got7fsn_ti T-lymphocyte selection|T lymphocyte selection|T-cell selection Wikipedia:Thymocyte biological_process owl:Class
GO:0002376 biolink:NamedThing immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. got7fsn_ti Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). Wikipedia:Immune_system biological_process owl:Class
GO:0001656 biolink:NamedThing metanephros development The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti biological_process owl:Class
GO:0001822 biolink:NamedThing kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine. got7fsn_ti nephrogenesis Wikipedia:Kidney_development biological_process owl:Class
GO:0019453 biolink:NamedThing L-cysteine catabolic process via cystine The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine. got7fsn_ti L-cysteine breakdown via cystine|L-cysteine degradation via cystine biological_process owl:Class
GO:0019448 biolink:NamedThing L-cysteine catabolic process The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid. got7fsn_ti L-cysteine degradation|L-cysteine breakdown|L-cysteine catabolism biological_process owl:Class
GO:0019390 biolink:NamedThing glucuronoside biosynthetic process The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue. got7fsn_ti glucuronoside biosynthesis|glucuronide biosynthesis|glucuronoside formation|glucuronoside synthesis|glucuronoside anabolism|glucuronide biosynthetic process biological_process owl:Class
GO:0106032 biolink:NamedThing snRNA pseudouridine synthase activity Catalysis of the reaction: an snRNA uridine = an snRNA pseudouridine. Conversion of uridine in an snRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. got7fsn_ti hjd 2017-06-28T17:44:20Z molecular_function owl:Class
GO:0140098 biolink:NamedThing catalytic activity, acting on RNA Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21612|https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-14T12:05:21Z molecular_function owl:Class
GO:0055127 biolink:NamedThing vibrational conductance of sound to the inner ear The transmission of vibrations via ossicles to the inner ear. got7fsn_ti jid 2009-10-13T10:59:39Z biological_process owl:Class
GO:0070231 biolink:NamedThing T cell apoptotic process Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. got7fsn_ti T cell apoptosis|programmed cell death of T cells by apoptosis|T-lymphocyte apoptosis|T lymphocyte apoptosis|T-cell apoptosis biological_process owl:Class
GO:0043271 biolink:NamedThing negative regulation of ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti down-regulation of ion transport|down regulation of ion transport|inhibition of ion transport|downregulation of ion transport biological_process owl:Class
GO:0043269 biolink:NamedThing regulation of ion transport Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0030059 biolink:NamedThing aralkylamine dehydrogenase (azurin) activity Catalysis of the reaction: an aralkylamine + H2O + 2 oxidized [azurin] = an aromatic aldehyde + 2 H+ + NH4+ + 2 reduced [azurin]. got7fsn_ti aralkylamine:(azurin) oxidoreductase (deaminating) activity|aromatic amine dehydrogenase (azurin) activity RHEA:47796|EC:1.4.9.2|MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0042915 biolink:NamedThing group A colicin transport The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0042914 biolink:NamedThing colicin transport The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1. got7fsn_ti biological_process owl:Class
GO:1990490 biolink:NamedThing archaeal proton-transporting A-type ATPase complex A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea. got7fsn_ti archaeal A-type ATPase protein complex|A-type ATPase protein complex tt 2014-09-20T19:13:55Z cellular_component owl:Class
GO:0016469 biolink:NamedThing proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. got7fsn_ti vacuolar hydrogen-transporting ATPase|hydrogen-transporting two-sector ATPase complex cellular_component owl:Class
GO:0010136 biolink:NamedThing ureide catabolic process The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium. got7fsn_ti ureide breakdown|ureide degradation|ureide catabolism MetaCyc:URDEGR-PWY biological_process owl:Class
GO:0009830 biolink:NamedThing cell wall modification involved in abscission A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission. got7fsn_ti cell wall modification during abscission biological_process owl:Class
GO:0050463 biolink:NamedThing nitrate reductase [NAD(P)H] activity Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+. got7fsn_ti nitrite:NAD(P)+ oxidoreductase activity|nitrate reductase NAD(P)H activity|assimilatory nitrate reductase activity|nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity|nitrate reductase [NAD(P)H2]|NAD(P)H:nitrate oxidoreductase activity|assimilatory NAD(P)H-nitrate reductase activity|NAD(P)H2:nitrate oxidoreductase activity|NAD(P)H-nitrate reductase activity|NAD(P)H bispecific nitrate reductase activity EC:1.7.1.2 molecular_function owl:Class
GO:0008940 biolink:NamedThing nitrate reductase activity Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor. got7fsn_ti nitrite:(acceptor) oxidoreductase|nitrate reductase (acceptor)|respiratory nitrate reductase activity|nitrite:acceptor oxidoreductase RHEA:21068|MetaCyc:NITRATREDUCT-RXN|EC:1.7.99.4 molecular_function owl:Class
GO:0045763 biolink:NamedThing negative regulation of cellular amino acid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid. got7fsn_ti inhibition of amino acid metabolic process|down-regulation of amino acid metabolic process|negative regulation of amino acid metabolism|down regulation of amino acid metabolic process|downregulation of amino acid metabolic process biological_process owl:Class
GO:0033239 biolink:NamedThing negative regulation of cellular amine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines. got7fsn_ti negative regulation of amine metabolism biological_process owl:Class
GO:0030836 biolink:NamedThing positive regulation of actin filament depolymerization Any process that activates or increases the frequency, rate or extent of actin depolymerization. got7fsn_ti actin filament destabilization|positive regulation of actin depolymerization|up-regulation of actin filament depolymerization|upregulation of actin filament depolymerization|positive regulation of actin polymerization and/or depolymerization|activation of actin filament depolymerization|up regulation of actin filament depolymerization|stimulation of actin filament depolymerization Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838'). GO:0030045 biological_process owl:Class
GO:0051495 biolink:NamedThing positive regulation of cytoskeleton organization Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. got7fsn_ti up-regulation of cytoskeleton organization|positive regulation of cytoskeleton organisation|activation of cytoskeleton organization|stimulation of cytoskeleton organization|up regulation of cytoskeleton organization|upregulation of cytoskeleton organization|positive regulation of cytoskeleton organization and biogenesis biological_process owl:Class
GO:0075528 biolink:NamedThing modulation by virus of host immune response The process in which a virus effects a change in the host immune response. got7fsn_ti regulation by virus of host immune system process jl 2011-08-04T02:47:57Z biological_process owl:Class
GO:0004769 biolink:NamedThing steroid delta-isomerase activity Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. got7fsn_ti hydroxysteroid isomerase activity|delta(5)-3-ketosteroid isomerase activity|3-oxosteroid delta5-delta4-isomerase activity|delta5-3-keto steroid isomerase activity|delta5-3-oxosteroid isomerase activity|delta5(or delta4)-3-keto steroid isomerase activity|delta5-3-ketosteroid isomerase activity|steroid D-isomerase activity|delta5-ketosteroid isomerase activity|delta(5)-3-oxosteroid isomerase activity|steroid isomerase activity|delta(5)-steroid isomerase activity|delta(5)-3-keto steroid isomerase activity|3-oxosteroid isomerase activity|delta5-steroid isomerase activity Reactome:R-HSA-193052|Reactome:R-HSA-6807052|Reactome:R-HSA-193961|Reactome:R-HSA-195690|RHEA:14709|EC:5.3.3.1|MetaCyc:STEROID-DELTA-ISOMERASE-RXN|Reactome:R-HSA-193073 molecular_function owl:Class
GO:0033821 biolink:NamedThing DNA beta-glucosyltransferase activity Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA. got7fsn_ti uridine diphosphoglucose-deoxyribonucleate beta-glucosyltransferase activity|UDP glucose-DNA beta-glucosyltransferase activity|T4-beta-glucosyl transferase activity|T4-HMC-beta-glucosyl transferase activity|UDPglucose:DNA beta-D-glucosyltransferase activity|T4 phage beta-glucosyltransferase activity|UDP-glucose:DNA beta-D-glucosyltransferase activity MetaCyc:2.4.1.27-RXN|EC:2.4.1.27 molecular_function owl:Class
GO:0019778 biolink:NamedThing Atg12 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti APG12 activating enzyme activity molecular_function owl:Class
GO:0008641 biolink:NamedThing ubiquitin-like modifier activating enzyme activity Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti small protein activating enzyme activity https://github.com/geneontology/go-ontology/issues/14208 GO:0008642 molecular_function owl:Class
GO:0004501 biolink:NamedThing ecdysone 20-monooxygenase activity Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O. got7fsn_ti ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)|ecdysone 20-hydroxylase activity|ecdysone modification|alpha-ecdysone C-20 hydroxylase activity EC:1.14.99.22|KEGG_REACTION:R02374|MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN|RHEA:14021 molecular_function owl:Class
GO:0001532 biolink:NamedThing interleukin-21 receptor activity Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-21R|IL-21 receptor activity molecular_function owl:Class
GO:0030868 biolink:NamedThing smooth endoplasmic reticulum membrane The lipid bilayer surrounding the smooth endoplasmic reticulum. got7fsn_ti SER membrane|smooth ER membrane NIF_Subcellular:sao1596955044 cellular_component owl:Class
GO:0005789 biolink:NamedThing endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. got7fsn_ti ER membrane cellular_component owl:Class
GO:0048457 biolink:NamedThing floral whorl morphogenesis The process in which the anatomical structures of the floral whorl are generated and organized. got7fsn_ti GO:0048414 biological_process owl:Class
GO:1990904 biolink:NamedThing ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules. got7fsn_ti protein-RNA complex|intracellular ribonucleoprotein complex|ribonucleoprotein complex|RNA-protein complex|RNP|extracellular ribonucleoprotein complex pr 2015-11-19T12:26:37Z GO:0030529|GO:1990903 Wikipedia:Ribonucleoprotein cellular_component owl:Class
GO:0061656 biolink:NamedThing SUMO conjugating enzyme activity Isoenergetic transfer of SUMO from one protein to another via the reaction X-SUMO + Y -> Y-SUMO + X, where both the X-SUMO and Y-SUMO linkages are thioester bonds between the C-terminal amino acid of SUMO and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:33:20Z molecular_function owl:Class
GO:0061650 biolink:NamedThing ubiquitin-like protein conjugating enzyme activity Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2|small conjugating protein conjugating enzyme activity dph 2014-11-06T13:15:27Z molecular_function owl:Class
GO:0007147 biolink:NamedThing female meiosis II The cell cycle process in which the second meiotic division occurs in the female germline. got7fsn_ti female meiosis II nuclear division biological_process owl:Class
GO:0007143 biolink:NamedThing female meiotic nuclear division A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline. got7fsn_ti female meiosis|female meiotic division Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. biological_process owl:Class
GO:0018559 biolink:NamedThing 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate. got7fsn_ti 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity UM-BBD_reactionID:r0442|EC:1.13.11.- molecular_function owl:Class
GO:0052872 biolink:NamedThing tocotrienol omega-hydroxylase activity Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13'-hydroxy-tocotrienol + NADP+ + H2O . got7fsn_ti tocotrienol 13-hydroxylase activity ai 2012-01-30T03:07:27Z EC:1.14.13.- molecular_function owl:Class
GO:0071142 biolink:NamedThing homomeric SMAD protein complex A protein complex composed of a single type of SMAD family proteins. In the absence of Smad4, phosphorylation of R-SMADs results in their homotrimerization. However, these complexes do not appear to import into the nucleus and are assumed to be transcriptionally inactive. got7fsn_ti SMAD3 homotrimer complex|SMAD1 protein complex|SMAD2 homotrimer complex|SMAD2 protein complex|SMAD1 homotrimer complex|SMAD3 protein complex mah 2009-11-16T02:41:19Z GO:0071143 cellular_component owl:Class
GO:0071141 biolink:NamedThing SMAD protein complex A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven. got7fsn_ti SMAD complex mah 2009-11-16T02:28:59Z cellular_component owl:Class
GO:0102982 biolink:NamedThing UDP-3-dehydro-alpha-D-glucose dehydrogenase activity Catalysis of the reaction: UDP-alpha-D-glucose + NAD <=> H+ + UDP-3-keto-alpha-D-glucose + NADH. got7fsn_ti RHEA:35755|MetaCyc:RXN-9578 molecular_function owl:Class
GO:0021614 biolink:NamedThing glossopharyngeal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. got7fsn_ti CN IX maturation biological_process owl:Class
GO:0052338 biolink:NamedThing disruption by host of symbiont cell wall The chemical reactions and pathways performed by an organism resulting in the breakdown of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti degradation of symbiont cell wall by organism|disassembly by host of symbiont cell wall|catabolism of symbiont cell wall by organism biological_process owl:Class
GO:0052339 biolink:NamedThing disruption by organism of cell wall of other organism involved in symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of the cell wall of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti disassembly by organism of cell wall of other organism during symbiotic interaction biological_process owl:Class
GO:0120098 biolink:NamedThing procentriole A cellular structure that is the site of a developing centriole, which will become a microtubule organizing center. During the canonical pathway of centriole duplication that occurs during the cell division cycle, procentrioles grow at the proximal ends of both mother and daughter centrioles. In the newly divided cells, the original mother and daughter centrioles become mother centrioles while the procentrioles become the new daughter centrioles. Procentrioles can also arise from de novo pathways that occur in multiciliated cells. In ciliated epithelial cells, numerous procentrioles arise form electron dense material referred to as fibrous granules and deuterosomes. The pathway of procentriole formation in multiciliated protists appears to be similar to that in mammalian multiciliated epithelium. In sperm of primative land plants, multiple procentrioles are formed from a blepharoplast giving rise to multicilated sperm cells. got7fsn_ti krc 2017-09-28T21:22:56Z cellular_component owl:Class
GO:0031327 biolink:NamedThing negative regulation of cellular biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. got7fsn_ti downregulation of cellular biosynthetic process|negative regulation of cellular biosynthesis|negative regulation of cellular anabolism|negative regulation of cellular synthesis|negative regulation of cellular formation|down-regulation of cellular biosynthetic process|inhibition of cellular biosynthetic process|down regulation of cellular biosynthetic process biological_process owl:Class
GO:0009651 biolink:NamedThing response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. got7fsn_ti salinity response|response to ionic osmotic stress biological_process owl:Class
GO:0006970 biolink:NamedThing response to osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. got7fsn_ti osmotic response|osmotic stress response biological_process owl:Class
GO:0032344 biolink:NamedThing regulation of aldosterone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. got7fsn_ti regulation of aldosterone metabolism biological_process owl:Class
GO:0050212 biolink:NamedThing progesterone 11-alpha-monooxygenase activity Catalysis of the reaction: AH(2) + O(2) + progesterone = 11alpha-hydroxyprogesterone + A + H(2)O. got7fsn_ti progesterone 11-alpha-hydroxylase activity|progesterone 11alpha-hydroxylase activity|progesterone,hydrogen-donor:oxygen oxidoreductase (11alpha-hydroxylating)|progesterone 11a-monooxygenase activity|progesterone 11alpha-monooxygenase activity EC:1.14.99.14|RHEA:18205|MetaCyc:PROGESTERONE-11-ALPHA-MONOOXYGENASE-RXN|KEGG_REACTION:R02214 molecular_function owl:Class
GO:0035742 biolink:NamedThing activated CD8-positive, alpha-beta T cell proliferation The expansion of an activated CD8-positive, alpha-beta T cell population by cell division. got7fsn_ti bf 2011-03-17T02:19:58Z biological_process owl:Class
GO:0103088 biolink:NamedThing 2-(6'-methylthio)hexylmalate synthase activity Catalysis of the reaction: 2-oxo-8-methylthiooctanoate + acetyl-CoA + H2O <=> H+ + 2-(6'-methylthio)hexylmalate + coenzyme A. got7fsn_ti MetaCyc:RXNQT-4172 molecular_function owl:Class
GO:0009000 biolink:NamedThing selenocysteine lyase activity Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor. got7fsn_ti selenocysteine beta-lyase activity|selenocysteine reductase activity|L-selenocysteine selenide-lyase (L-alanine-forming) MetaCyc:SELENOCYSTEINE-LYASE-RXN|EC:4.4.1.16|RHEA:11632|Reactome:R-HSA-2408524 molecular_function owl:Class
GO:0047062 biolink:NamedThing trans-acenaphthene-1,2-diol dehydrogenase activity Catalysis of the reaction: (+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 H(+) + 2 NADPH. got7fsn_ti trans-1,2-acenaphthenediol dehydrogenase activity|(+-)-trans-acenaphthene-1,2-diol:NADP+ oxidoreductase activity MetaCyc:1.10.1.1-RXN|RHEA:22184|KEGG_REACTION:R04059|EC:1.10.1.1 molecular_function owl:Class
GO:0016680 biolink:NamedThing oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti EC:1.10.1.- molecular_function owl:Class
GO:0032525 biolink:NamedThing somite rostral/caudal axis specification The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary. got7fsn_ti somite rostrocaudal polarity|somite rostrocaudal axis specification biological_process owl:Class
GO:0000578 biolink:NamedThing embryonic axis specification The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo. got7fsn_ti embryonic axis determination biological_process owl:Class
GO:0042930 biolink:NamedThing enterobactin transport The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti enterochelin transport biological_process owl:Class
GO:0015891 biolink:NamedThing siderophore transport The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti siderophore-iron transport|siderochrome transport|iron-siderochrome transport|iron-siderophore transport GO:0015892 biological_process owl:Class
GO:0030560 biolink:NamedThing tRNA pseudouridylation guide activity Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0030558 biolink:NamedThing RNA pseudouridylation guide activity Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0050531 biolink:NamedThing mannosyl-3-phosphoglycerate phosphatase activity Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate. got7fsn_ti alpha-D-mannosyl-3-phosphoglycerate phosphohydrolase activity EC:3.1.3.70|MetaCyc:3.1.3.70-RXN|KEGG_REACTION:R05790|RHEA:19309 molecular_function owl:Class
GO:0070874 biolink:NamedThing negative regulation of glycogen metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glycogen. got7fsn_ti negative regulation of glycogen metabolism mah 2009-08-20T02:50:41Z biological_process owl:Class
GO:0033953 biolink:NamedThing alpha-agarase activity Catalysis of the endohydrolysis of 1,3-alpha-L-galactosidic linkages in agarose, yielding agarotetraose as the major product. got7fsn_ti agarose 3-glycanohydrolase activity|agarase A33 activity|agarase activity EC:3.2.1.158|MetaCyc:3.2.1.158-RXN molecular_function owl:Class
GO:0030586 biolink:NamedThing [methionine synthase] reductase activity Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+. got7fsn_ti methionine synthase reductase activity|5-methyltetrahydrofolate-homocysteine methyltransferase reductase|[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity|methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity|methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)|methionine synthase cob(II)alamin reductase (methylating) activity Formerly EC:2.1.1.135. Reactome:R-HSA-3149518|RHEA:23908|EC:1.16.1.8|MetaCyc:2.1.1.135-RXN molecular_function owl:Class
GO:0016723 biolink:NamedThing oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor. got7fsn_ti oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor|oxidoreductase activity, reducing metal ions, NAD or NADP as acceptor https://github.com/geneontology/go-ontology/issues/20675 Reactome:R-HSA-917811|EC:1.16.1.- molecular_function owl:Class
GO:0008720 biolink:NamedThing D-lactate dehydrogenase activity Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate. got7fsn_ti D-lactic acid dehydrogenase activity|D-lactic dehydrogenase activity MetaCyc:DLACTDEHYDROGNAD-RXN|EC:1.1.1.28|KEGG_REACTION:R00704|RHEA:16369 molecular_function owl:Class
GO:0004457 biolink:NamedThing lactate dehydrogenase activity Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate. got7fsn_ti molecular_function owl:Class
GO:0007283 biolink:NamedThing spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. got7fsn_ti generation of spermatozoa Wikipedia:Spermatogenesis biological_process owl:Class
GO:0018780 biolink:NamedThing dichloroacetate halidohydrolase activity Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate. got7fsn_ti UM-BBD_reactionID:r0383 molecular_function owl:Class
GO:0031693 biolink:NamedThing alpha-1D adrenergic receptor binding Binding to an alpha-1D adrenergic receptor. got7fsn_ti alpha-1D adrenergic receptor ligand molecular_function owl:Class
GO:0042566 biolink:NamedThing hydrogenosome A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation. got7fsn_ti Wikipedia:Hydrogenosome cellular_component owl:Class
GO:0043231 biolink:NamedThing intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. got7fsn_ti intracellular membrane-enclosed organelle cellular_component owl:Class
GO:0061366 biolink:NamedThing behavioral response to chemical pain Any process that results in a change in the behaviour of an organism as a result of a chemical pain stimulus. got7fsn_ti dph 2010-10-21T03:25:01Z biological_process owl:Class
GO:0048266 biolink:NamedThing behavioral response to pain Any process that results in a change in the behavior of an organism as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. got7fsn_ti behavioural response to pain biological_process owl:Class
GO:1990895 biolink:NamedThing regulation of protein localization to cell cortex of cell tip Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip. got7fsn_ti vw 2015-11-04T21:53:15Z biological_process owl:Class
GO:1904776 biolink:NamedThing regulation of protein localization to cell cortex Any process that modulates the frequency, rate or extent of protein localization to cell cortex. got7fsn_ti regulation of protein localisation to cell cortex An example is cye-1 in C. elegans, UniProt ID O01501 in PMID:17115027. es 2015-10-29T16:55:01Z biological_process owl:Class
GO:0102913 biolink:NamedThing 3-aminomethylindole N-methyltransferase activity Catalysis of the reaction: indol-3-ylmethylamine + S-adenosyl-L-methionine = H+ + N-methyl-3-aminomethylindole + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:52268|MetaCyc:RXN-8686 molecular_function owl:Class
GO:0016518 biolink:NamedThing interleukin-14 receptor activity Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-14R|IL-14 receptor activity molecular_function owl:Class
GO:0008610 biolink:NamedThing lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. got7fsn_ti lipid formation|lipid biosynthesis|lipid anabolism|lipid synthesis|lipogenesis biological_process owl:Class
GO:0030897 biolink:NamedThing HOPS complex A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion. got7fsn_ti cellular_component owl:Class
GO:0010108 biolink:NamedThing detection of glutamine The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal. got7fsn_ti glutamine detection|glutamine perception|glutamine sensing biological_process owl:Class
GO:0009593 biolink:NamedThing detection of chemical stimulus The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of chemical substance|detection of chemical substance|chemoreception|chemoperception|perception of chemical stimulus biological_process owl:Class
GO:0102469 biolink:NamedThing naringenin 2-hydroxylase activity Catalysis of the reaction: (S)-naringenin + NADPH + O2 <=> 2-hydroxynaringenin + NADP + H2O. got7fsn_ti RHEA:57588|MetaCyc:RXN-14069 molecular_function owl:Class
GO:0047539 biolink:NamedThing 2-deoxyglucosidase activity Catalysis of the reaction: H2O + a 2-deoxy-alpha-D-glucoside = 2-deoxy-D-glucose + an alcohol. got7fsn_ti 2-deoxy-alpha-D-glucosidase activity|2-deoxy-alpha-D-glucoside deoxyglucohydrolase activity|2-deoxy-alpha-glucosidase activity EC:3.2.1.112|MetaCyc:2-DEOXYGLUCOSIDASE-RXN|RHEA:15317 molecular_function owl:Class
GO:0015926 biolink:NamedThing glucosidase activity Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. got7fsn_ti molecular_function owl:Class
GO:0046219 biolink:NamedThing indolalkylamine biosynthetic process The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. got7fsn_ti indolalkylamine biosynthesis|indolalkylamine formation|indolalkylamine anabolism|indolalkylamine synthesis biological_process owl:Class
GO:0042401 biolink:NamedThing cellular biogenic amine biosynthetic process The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. got7fsn_ti biogenic amine synthesis|biogenic amine anabolism|biogenic amine biosynthesis|biogenic amine formation biological_process owl:Class
GO:0002018 biolink:NamedThing renin-angiotensin regulation of aldosterone production The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone. got7fsn_ti renin-angiotensin control of aldosterone production biological_process owl:Class
GO:2000858 biolink:NamedThing regulation of aldosterone secretion Any process that modulates the frequency, rate or extent of aldosterone secretion. got7fsn_ti bf 2011-07-26T08:47:27Z biological_process owl:Class
GO:0036035 biolink:NamedThing osteoclast development The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. got7fsn_ti osteoclast cell development bf 2011-11-02T05:20:35Z biological_process owl:Class
GO:2000113 biolink:NamedThing negative regulation of cellular macromolecule biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process. got7fsn_ti negative regulation of cellular macromolecule synthesis|negative regulation of cellular macromolecule formation|negative regulation of cellular macromolecule biosynthesis|negative regulation of cellular biopolymer biosynthetic process|negative regulation of cellular macromolecule anabolism tb 2010-09-15T08:55:48Z biological_process owl:Class
GO:2000112 biolink:NamedThing regulation of cellular macromolecule biosynthetic process Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process. got7fsn_ti regulation of cellular macromolecule synthesis|regulation of cellular macromolecule anabolism|regulation of cellular macromolecule biosynthesis|regulation of cellular biopolymer biosynthetic process|regulation of cellular macromolecule formation tb 2010-09-15T08:55:45Z biological_process owl:Class
GO:0102013 biolink:NamedThing ATPase-coupled L-glutamate tranmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-glutamate(out) -> ADP + phosphate + L-glutamate(in). got7fsn_ti L-glutamate-importing ATPase activity MetaCyc:ABC-13-RXN molecular_function owl:Class
GO:0015426 biolink:NamedThing ATPase-coupled polar amino acid-transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in). got7fsn_ti polar-amino acid-transporting ATPase activity|cystine/diaminopimelate porter activity|polar amino acid-importing ATPase activity|polar-amino acid-importing ATPase activity|polar-amino acid ABC transporter|histidine permease activity|polar-amino-acid-transporting ATPase activity|ATP-dependent polar amino acid-transporter activity|polar amino acid uptake transporter activity|glutamate/aspartate porter activity|histidine/arginine/lysine/ornithine porter activity RHEA:14673|MetaCyc:3.6.3.21-RXN|EC:7.4.2.1 molecular_function owl:Class
GO:0050276 biolink:NamedThing scyllo-inosamine 4-kinase activity Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H(+). got7fsn_ti ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase activity|scyllo-inosamine kinase (phosphorylating)|scyllo-inosamine kinase activity|ATP:inosamine phosphotransferase activity RHEA:18605|EC:2.7.1.65|KEGG_REACTION:R03384|MetaCyc:SCYLLO-INOSAMINE-KINASE-RXN molecular_function owl:Class
GO:0062187 biolink:NamedThing anandamide 8,9 epoxidase activity Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(8,9-epoxy-5Z,11Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti dph 2019-11-26T18:51:34Z RHEA:53140 molecular_function owl:Class
GO:0062186 biolink:NamedThing anandamide epoxidase activity Catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide. got7fsn_ti arachidonoylethanolamide epoxidase activity dph 2019-11-26T18:49:50Z molecular_function owl:Class
GO:0005591 biolink:NamedThing collagen type VIII trimer A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets. got7fsn_ti cellular_component owl:Class
GO:0005598 biolink:NamedThing short-chain collagen trimer Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils. got7fsn_ti cellular_component owl:Class
GO:0019876 biolink:NamedThing nylon catabolic process The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. got7fsn_ti nylon breakdown|nylon degradation|nylon catabolism biological_process owl:Class
GO:0036286 biolink:NamedThing eisosome filament A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1. got7fsn_ti linear eisosome bf 2012-07-16T10:52:24Z cellular_component owl:Class
GO:0000985 biolink:NamedThing bacterial-type RNA polymerase core promoter sequence-specific DNA binding Binding to a DNA sequence that is part of the core promoter of a bacterial gene. got7fsn_ti eubacterial-type RNA polymerase core promoter sequence-specific DNA binding krc 2010-08-10T03:01:38Z molecular_function owl:Class
GO:0050397 biolink:NamedThing Watasenia-luciferin 2-monooxygenase activity Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light. got7fsn_ti Watasenia-luciferin:oxygen 2-oxidoreductase (decarboxylating)|Watasenia-type luciferase activity|luciferase activity RHEA:18057|EC:1.13.12.8|MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0045289 biolink:NamedThing luciferin monooxygenase activity Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation. got7fsn_ti luciferase monooxygenase activity|luciferase activity molecular_function owl:Class
GO:0072765 biolink:NamedThing centromere localization A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location. got7fsn_ti kinetochore localization|kinetochore localisation|establishment and maintenance of kinetochore localization mah 2012-11-21T13:30:53Z biological_process owl:Class
GO:0051640 biolink:NamedThing organelle localization Any process in which an organelle is transported to, and/or maintained in, a specific location. got7fsn_ti establishment and maintenance of organelle localization|organelle localisation biological_process owl:Class
GO:0060493 biolink:NamedThing mesenchymal-endodermal cell signaling involved in lung induction Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell in the foregut and contributes to the formation of the lung bud. got7fsn_ti mesenchymal-endodermal cell signalling involved in lung induction biological_process owl:Class
GO:0060494 biolink:NamedThing inductive mesenchymal-endodermal cell signaling Any process that mediates the transfer of information from a mesenchymal cell to an endodermal cell changing the fate of the endodermal cell. got7fsn_ti inductive mesenchymal-endodermal cell signalling biological_process owl:Class
GO:0044780 biolink:NamedThing bacterial-type flagellum assembly The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. got7fsn_ti bacterial flagellum assembly jl 2013-03-27T15:00:43Z biological_process owl:Class
GO:0030031 biolink:NamedThing cell projection assembly Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon. got7fsn_ti formation of a cell surface projection|cell projection biogenesis biological_process owl:Class
GO:0000310 biolink:NamedThing xanthine phosphoribosyltransferase activity Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate. got7fsn_ti 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity|Xan phosphoribosyltransferase activity|xanthine-guanine phosphoribosyltransferase activity|XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity|xanthylate pyrophosphorylase activity|xanthylic pyrophosphorylase activity|XMP pyrophosphorylase activity|xanthosine 5'-phosphate pyrophosphorylase activity GO:0009043 RHEA:10800|EC:2.4.2.22|MetaCyc:XANPRIBOSYLTRAN-RXN molecular_function owl:Class
GO:0106130 biolink:NamedThing purine phosphoribosyltransferase activity Catalysis of the reaction: RMP + diphosphate = R + 5-phospho-alpha-D-ribose 1-diphosphate. got7fsn_ti hjd 2018-06-14T17:38:53Z molecular_function owl:Class
GO:0044169 biolink:NamedThing host cell rough endoplasmic reticulum membrane The lipid bilayer surrounding the host cell rough endoplasmic reticulum. got7fsn_ti host rough endoplasmic reticulum membrane jl 2009-09-04T11:30:38Z cellular_component owl:Class
GO:0044167 biolink:NamedThing host cell endoplasmic reticulum membrane The lipid bilayer surrounding the host cell endoplasmic reticulum. got7fsn_ti host endoplasmic reticulum membrane jl 2009-09-04T11:19:23Z cellular_component owl:Class
GO:0048193 biolink:NamedThing Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. got7fsn_ti Golgi-derived vesicle transport biological_process owl:Class
GO:0005793 biolink:NamedThing endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport. got7fsn_ti ER-Golgi intermediate compartment|vesicular-tubular cluster|EGTC|ERGIC|endoplasmic reticulum-Golgi transport container|ER-Golgi transport container|pre-Golgi intermediate compartment|VTC Wikipedia:Vesicular-tubular_cluster cellular_component owl:Class
GO:0019767 biolink:NamedThing IgE receptor activity Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0019763 biolink:NamedThing immunoglobulin receptor activity Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti FC receptor activity GO:0016489 molecular_function owl:Class
GO:1990189 biolink:NamedThing peptide-serine-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide. got7fsn_ti tb 2013-09-11T20:13:40Z molecular_function owl:Class
GO:0004596 biolink:NamedThing peptide alpha-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein. got7fsn_ti N(alpha)-acetyltransferase activity|acetyl-CoA:peptide alpha-N-acetyltransferase activity|acetyl-CoA:peptide nalpha-acetyltransferase activity|amino-terminal amino acid-acetylating enzyme activity|protein N-terminal acetyltransferase activity|beta-endorphin acetyltransferase activity|NAT activity|peptide acetyltransferase activity|nalpha-acetyltransferase activity Reactome:R-HSA-6814090|MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:0047804 biolink:NamedThing cysteine-S-conjugate beta-lyase activity Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate. got7fsn_ti L-cysteine-S-conjugate thiol-lyase (deaminating; pyruvate-forming)|L-cysteine-S-conjugate thiol-lyase (deaminating) activity|cysteine-S-conjugate b-lyase activity|glutamine transaminase K/cysteine conjugate beta-lyase activity|cysteine conjugate beta-lyase activity RHEA:18121|MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN|EC:4.4.1.13 molecular_function owl:Class
GO:0001879 biolink:NamedThing detection of yeast The series of events in which a stimulus from a yeast is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0016046 biolink:NamedThing detection of fungus The series of events in which a stimulus from a fungus is received and converted into a molecular signal. got7fsn_ti perception of fungus|perception of parasitic fungus|detection of parasitic fungus|perception of fungi|perception of parasitic fungi|detection of fungi|detection of parasitic fungi GO:0009599|GO:0016047 biological_process owl:Class
GO:0102394 biolink:NamedThing 4-hydroxy-L-isoleucine dehydrogenase activity Catalysis of the reaction: (2S,3R,4S)-4-hydroxy-L-isoleucine + NAD <=> (2S,3R)-2-amino-3-methyl-4-ketopentanoate + NADH + H+. got7fsn_ti MetaCyc:RXN-13637 molecular_function owl:Class
GO:0047345 biolink:NamedThing ribose-5-phosphate adenylyltransferase activity Catalysis of the reaction: D-ribose 5-phosphate + ADP + H(+) = ADP-ribose + phosphate. got7fsn_ti ADP:D-ribose-5-phosphate adenylyltransferase activity|ADP ribose phosphorylase activity|ADP-ribose phosphorylase activity|ADP:ribose-5-phosphate adenylyltransferase activity|adenosine diphosphoribose phosphorylase activity MetaCyc:2.7.7.35-RXN|EC:2.7.7.35|RHEA:14529|KEGG_REACTION:R01052 molecular_function owl:Class
GO:0070566 biolink:NamedThing adenylyltransferase activity Catalysis of the transfer of an adenylyl group to an acceptor. got7fsn_ti mah 2009-04-15T11:04:22Z molecular_function owl:Class
GO:0002680 biolink:NamedThing pro-T cell lineage commitment The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell. got7fsn_ti pro-T lymphocyte lineage commitment|pro-T lymphocyte fate commitment|pro-T cell fate commitment biological_process owl:Class
GO:0000446 biolink:NamedThing nucleoplasmic THO complex The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits. got7fsn_ti cellular_component owl:Class
GO:0004834 biolink:NamedThing tryptophan synthase activity Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. got7fsn_ti L-serine hydro-lyase (adding indoleglycerol-phosphate)|tryptophan desmolase activity|L-tryptophan synthetase activity|indoleglycerol phosphate aldolase activity|L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]|tryptophan synthetase activity MetaCyc:TRYPSYN-RXN|EC:4.2.1.20|RHEA:10532|KEGG_REACTION:R02722 molecular_function owl:Class
GO:0000756 biolink:NamedThing response to pheromone regulating conjugation with mutual genetic exchange Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion. got7fsn_ti response to pheromone triggering conjugation without cellular fusion biological_process owl:Class
GO:0071444 biolink:NamedThing cellular response to pheromone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. got7fsn_ti cellular pheromone response mah 2009-12-16T04:05:33Z biological_process owl:Class
GO:0050154 biolink:NamedThing opheline kinase activity Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H(+). got7fsn_ti ATP:guanidinoethyl-methyl-phosphate phosphotransferase activity KEGG_REACTION:R04388|EC:2.7.3.7|MetaCyc:OPHELINE-KINASE-RXN|RHEA:17553 molecular_function owl:Class
GO:0032892 biolink:NamedThing positive regulation of organic acid transport Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti stimulation of organic acid transport|activation of organic acid transport|up-regulation of organic acid transport|upregulation of organic acid transport|up regulation of organic acid transport biological_process owl:Class
GO:0032890 biolink:NamedThing regulation of organic acid transport Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0055023 biolink:NamedThing positive regulation of cardiac muscle tissue growth Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth. got7fsn_ti up-regulation of cardiac muscle growth|up regulation of cardiac muscle growth|upregulation of cardiac muscle growth|positive regulation of heart muscle growth|activation of cardiac muscle growth|stimulation of cardiac muscle growth biological_process owl:Class
GO:0060421 biolink:NamedThing positive regulation of heart growth Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. got7fsn_ti biological_process owl:Class
GO:0031725 biolink:NamedThing CXCR6 chemokine receptor binding Binding to a CXCR6 chemokine receptor. got7fsn_ti STRL33 receptor binding|bonzo receptor binding|CXCR6 chemokine receptor ligand molecular_function owl:Class
GO:0045236 biolink:NamedThing CXCR chemokine receptor binding Binding to a chemokine receptor in the CXCR family. got7fsn_ti CXC chemokine receptor ligand|C-X-C chemokine receptor ligand|alpha chemokine receptor ligand|alpha chemokine receptor binding molecular_function owl:Class
GO:0032197 biolink:NamedThing transposition, RNA-mediated Any process involved in a type of transpositional recombination which occurs via an RNA intermediate. got7fsn_ti Ty element transposition|retrotransposon transposition|retrotransposition|RNA-mediated transposition|Ty2 element transposition|Ty3 element transposition|Tf transposition|Ty1 element transposition|Class I transposition GO:0006322|GO:0006319|GO:0006321|GO:0006320 Wikipedia:Transposon##Class_I:_Retrotransposons biological_process owl:Class
GO:0032196 biolink:NamedThing transposition Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. got7fsn_ti Wikipedia:Transposon biological_process owl:Class
GO:0020023 biolink:NamedThing kinetoplast A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum. got7fsn_ti Wikipedia:Kinetoplast cellular_component owl:Class
GO:0048770 biolink:NamedThing pigment granule A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes. got7fsn_ti cellular_component owl:Class
GO:0031410 biolink:NamedThing cytoplasmic vesicle A vesicle found in the cytoplasm of a cell. got7fsn_ti cytoplasmic membrane bounded vesicle|cytoplasmic, membrane-bounded vesicle|cytoplasmic membrane-enclosed vesicle GO:0016023 NIF_Subcellular:sao180601769 cellular_component owl:Class
GO:0050774 biolink:NamedThing negative regulation of dendrite morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. got7fsn_ti down regulation of dendrite morphogenesis|inhibition of dendrite morphogenesis|down-regulation of dendrite morphogenesis|downregulation of dendrite morphogenesis biological_process owl:Class
GO:0050768 biolink:NamedThing negative regulation of neurogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. got7fsn_ti down regulation of neurogenesis|inhibition of neurogenesis|downregulation of neurogenesis|down-regulation of neurogenesis biological_process owl:Class
GO:0031436 biolink:NamedThing BRCA1-BARD1 complex A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage. got7fsn_ti cellular_component owl:Class
GO:1900098 biolink:NamedThing regulation of plasma cell differentiation Any process that modulates the frequency, rate or extent of plasma cell differentiation. got7fsn_ti regulation of plasma cell development bf 2012-02-15T10:46:00Z biological_process owl:Class
GO:0002697 biolink:NamedThing regulation of immune effector process Any process that modulates the frequency, rate, or extent of an immune effector process. got7fsn_ti biological_process owl:Class
GO:0060065 biolink:NamedThing uterus development The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure. got7fsn_ti Mullerian tract development biological_process owl:Class
GO:0031798 biolink:NamedThing type 1 metabotropic glutamate receptor binding Binding to a type 1 metabotropic glutamate receptor. got7fsn_ti type 1 metabotropic glutamate receptor ligand molecular_function owl:Class
GO:0098604 biolink:NamedThing adenosylselenohomocysteinase activity Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine. got7fsn_ti dos 2014-04-16T10:53:22Z Reactome:R-HSA-2408532 molecular_function owl:Class
GO:0016802 biolink:NamedThing trialkylsulfonium hydrolase activity Catalysis of the hydrolysis of a thioether bond, -S-. got7fsn_ti thioether hydrolase activity|trialkylsulphonium hydrolase activity EC:3.3.1.- molecular_function owl:Class
GO:0052581 biolink:NamedThing (-)-isopiperitenone reductase activity Catalysis of the reaction: (6R)-isoperitenone + H(+) + NADPH = (2R,5R)-isopulegone + NADP(+). got7fsn_ti (+)-cis-isopulegone:NADP+ oxidoreductase activity ai 2010-08-09T04:42:05Z RHEA:25649|EC:1.3.1.82|KEGG_REACTION:R06417|MetaCyc:RXN-5161 molecular_function owl:Class
GO:0035671 biolink:NamedThing enone reductase activity Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+. got7fsn_ti bf 2011-02-04T10:59:15Z MetaCyc:RXN-12267 molecular_function owl:Class
GO:0099001 biolink:NamedThing viral genome ejection through host cell envelope, long flexible tail mechanism Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a long, flexible tail ejection system consisting a baseplate, a central tube and a terminator complex which attaches the tail to the phage capsid. Upon binding to the host cell surface, the baseplate changes its conformation and triggers genome ejection into the host cell cytoplasm. got7fsn_ti viral long flexible tail ejection system VZ:3952 biological_process owl:Class
GO:0046794 biolink:NamedThing transport of virus The directed movement of a virus, or part of a virus, into, out of, or within a host cell. got7fsn_ti viral transport|virion transport biological_process owl:Class
GO:0045109 biolink:NamedThing intermediate filament organization Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking. got7fsn_ti intermediate filament organisation biological_process owl:Class
GO:0045104 biolink:NamedThing intermediate filament cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins. got7fsn_ti intermediate filament cytoskeleton organisation|intermediate filament cytoskeleton organization and biogenesis biological_process owl:Class
GO:0047564 biolink:NamedThing 3-hydroxycyclohexanone dehydrogenase activity Catalysis of the reaction: 3-hydroxycyclohexanone + A = AH(2) + cyclohexane-1,3-dione. got7fsn_ti 3-hydroxycyclohexanone:acceptor 1-oxidoreductase activity MetaCyc:3-HYDROXYCYCLOHEXANONE-DEHYDROGENASE-RXN|RHEA:15905|EC:1.1.99.26|KEGG_REACTION:R03212 molecular_function owl:Class
GO:0102837 biolink:NamedThing 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8297|EC:1.14.19.35 molecular_function owl:Class
GO:2000609 biolink:NamedThing regulation of thyroid hormone generation Any process that modulates the frequency, rate or extent of thyroid hormone generation. got7fsn_ti yaf 2011-04-18T10:12:14Z biological_process owl:Class
GO:0051171 biolink:NamedThing regulation of nitrogen compound metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. got7fsn_ti regulation of nitrogen metabolic process|regulation of nitrogen metabolism biological_process owl:Class
GO:0006565 biolink:NamedThing L-serine catabolic process The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. got7fsn_ti L-serine breakdown|L-serine catabolism|L-serine degradation MetaCyc:SERDEG-PWY biological_process owl:Class
GO:0009071 biolink:NamedThing serine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. got7fsn_ti serine family amino acid degradation|serine family amino acid breakdown|serine family amino acid catabolism biological_process owl:Class
GO:0046843 biolink:NamedThing dorsal appendage formation Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration. got7fsn_ti biological_process owl:Class
GO:0044280 biolink:NamedThing subplasmalemmal coating Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier. got7fsn_ti jl 2010-01-14T03:58:38Z NIF_Subcellular:sao1938587839 cellular_component owl:Class
GO:0050841 biolink:NamedThing peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine. got7fsn_ti peptidyl-trimethyl-lysine hydroxylase activity|peptidyl trimethyl lysine hydroxylase activity RESID:AA0359 biological_process owl:Class
GO:0017185 biolink:NamedThing peptidyl-lysine hydroxylation The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine. got7fsn_ti biological_process owl:Class
GO:0033019 biolink:NamedThing 5-hydroxyvalerate dehydrogenase activity Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH. got7fsn_ti molecular_function owl:Class
GO:0021989 biolink:NamedThing olfactory cortex development The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors. got7fsn_ti biological_process owl:Class
GO:0047378 biolink:NamedThing acetylalkylglycerol acetylhydrolase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H(2)O = 1-alkyl-sn-glycerol + acetate + H(+). got7fsn_ti alkylacetylglycerol acetylhydrolase activity|2-acetyl-1-alkyl-sn-glycerol acetylhydrolase activity KEGG_REACTION:R04043|EC:3.1.1.71|RHEA:11552|MetaCyc:3.1.1.71-RXN molecular_function owl:Class
GO:0048469 biolink:NamedThing cell maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state. got7fsn_ti functional differentiation biological_process owl:Class
GO:1990723 biolink:NamedThing cytoplasmic periphery of the nuclear pore complex Cytoplasm situated in close proximity to a nuclear pore complex. got7fsn_ti associated with the nuclear pore https://github.com/geneontology/go-ontology/issues/21774 sl 2015-04-06T19:26:54Z cellular_component owl:Class
GO:0048471 biolink:NamedThing perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus. got7fsn_ti Note that this term should not be confused with the cellular component term 'nuclear membrane lumen ; GO:0005641', which has the synonym 'perinuclear space'. cellular_component owl:Class
GO:0050636 biolink:NamedThing vinorine synthase activity Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine. got7fsn_ti acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing) EC:2.3.1.160|KEGG_REACTION:R05876|MetaCyc:2.3.1.160-RXN|RHEA:24016 molecular_function owl:Class
GO:0016055 biolink:NamedThing Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. got7fsn_ti Wnt receptor signaling pathway|frizzled signaling pathway|frizzled signalling pathway|Wnt receptor signalling pathway|Wg signaling pathway|Wg signalling pathway|Wnt-activated signaling pathway|Wingless signalling pathway|Wingless signaling pathway GO:0007222 biological_process owl:Class
GO:0023003 biolink:NamedThing nuclear migration to the embryo sac center Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell. got7fsn_ti nuclear migration to the megagametophyte centre|nuclear migration to the megagametophyte center|nuclear migration to the female gametophyte center|nucleus migration to the female gametophyte centre|nuclear migration to the female gametophyte centre|nucleus migration to the female gametophyte center|nuclear migration to the embryo sac centre biological_process owl:Class
GO:0034513 biolink:NamedThing box H/ACA snoRNA binding Binding to a box H/ACA small nucleolar RNA. got7fsn_ti molecular_function owl:Class
GO:0030515 biolink:NamedThing snoRNA binding Binding to a small nucleolar RNA. got7fsn_ti molecular_function owl:Class
GO:0046550 biolink:NamedThing (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine biosynthetic process from asparagine The modification of asparagine to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine as found in microcin C7 produced from the mccA gene in E. coli plasmid pMccC7. got7fsn_ti (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine anabolism from asparagine|(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine formation from asparagine|(3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine synthesis from asparagine RESID:AA0328 biological_process owl:Class
GO:0018196 biolink:NamedThing peptidyl-asparagine modification The modification of peptidyl-asparagine. got7fsn_ti biological_process owl:Class
GO:0044324 biolink:NamedThing regulation of transcription involved in anterior/posterior axis specification Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis. got7fsn_ti jl 2010-08-04T12:35:41Z biological_process owl:Class
GO:0006357 biolink:NamedThing regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. got7fsn_ti regulation of transcription from Pol II promoter|regulation of transcription from RNA polymerase II promoter, global|regulation of transcription from RNA polymerase II promoter|regulation of global transcription from Pol II promoter|global transcription regulation from Pol II promoter|regulation of gene-specific transcription from RNA polymerase II promoter GO:0010551|GO:0006358 biological_process owl:Class
GO:0003265 biolink:NamedThing regulation of primary heart field cardioblast proliferation Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle. got7fsn_ti regulation of first heart field cardiac proliferation|regulation of first heart field cardioblast proliferation|regulation of FHF cardioblast proliferation dph 2009-10-15T02:25:26Z biological_process owl:Class
GO:0003264 biolink:NamedThing regulation of cardioblast proliferation Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti dph 2009-10-15T02:19:37Z biological_process owl:Class
GO:0031543 biolink:NamedThing peptidyl-proline dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. got7fsn_ti prolyl 4-hydroxylase activity|proline hydroxylase activity|prolyl hydroxylase activity|proline,2-oxoglutarate 4-dioxygenase activity molecular_function owl:Class
GO:0097343 biolink:NamedThing ripoptosome assembly The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. got7fsn_ti pr 2012-06-18T12:57:20Z biological_process owl:Class
GO:0065003 biolink:NamedThing protein-containing complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. got7fsn_ti chaperone activity|macromolecule complex assembly|macromolecular complex assembly|protein complex assembly|protein complex formation GO:0006461 biological_process owl:Class
GO:0022836 biolink:NamedThing gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. got7fsn_ti molecular_function owl:Class
GO:0015267 biolink:NamedThing channel activity Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. got7fsn_ti channel-forming toxin activity|pore class transporter activity|nonselective channel activity|substrate-specific channel activity|channel/pore class transporter activity|pore activity|alpha-type channel activity GO:0015268|GO:0022838|GO:0015249 TC:1|Reactome:R-HSA-3779381|Reactome:R-HSA-8953430 molecular_function owl:Class
GO:0047036 biolink:NamedThing codeinone reductase (NADPH) activity Catalysis of the reaction: codeine + NADP(+) = codeinone + H(+) + NADPH. got7fsn_ti codeine:NADP+ oxidoreductase activity KEGG_REACTION:R05124|RHEA:19209|EC:1.1.1.247|MetaCyc:1.1.1.247-RXN molecular_function owl:Class
GO:0018694 biolink:NamedThing p-cymene methyl hydroxylase activity Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol. got7fsn_ti EC:1.14.15.25|RHEA:51604|UM-BBD_reactionID:r0392|MetaCyc:RXN-661 molecular_function owl:Class
GO:0016725 biolink:NamedThing oxidoreductase activity, acting on CH or CH2 groups Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on CH or CH2 groups, other acceptors EC:1.17.-.- molecular_function owl:Class
GO:0140561 biolink:NamedThing EGF-domain serine glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16869 pg 2020-11-25T14:19:23Z RHEA:58116|EC:2.4.1.376 molecular_function owl:Class
GO:0050197 biolink:NamedThing phytanate-CoA ligase activity Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA. got7fsn_ti phytanoyl-CoA ligase activity|phytanate:CoA ligase (AMP-forming) RHEA:21380|EC:6.2.1.24|Reactome:R-HSA-389622|KEGG_REACTION:R03631|MetaCyc:PHYTANATE--COA-LIGASE-RXN molecular_function owl:Class
GO:0045485 biolink:NamedThing omega-6 fatty acid desaturase activity Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain. got7fsn_ti Reactome:R-HSA-2046092|Reactome:R-HSA-2046089 molecular_function owl:Class
GO:0019874 biolink:NamedThing 6-aminohexanoate-cyclic-dimer hydrolase activity Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate. got7fsn_ti 1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity KEGG_REACTION:R03448|UM-BBD_reactionID:r1097|MetaCyc:3.5.2.12-RXN|EC:3.5.2.12|RHEA:16225 molecular_function owl:Class
GO:0031582 biolink:NamedThing replication fork arrest at rDNA repeats A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer. got7fsn_ti replication fork blocking at rDNA repeats|replication fork arrest at ribosomal DNA repeats biological_process owl:Class
GO:0043007 biolink:NamedThing maintenance of rDNA Any process involved in sustaining the fidelity and copy number of rDNA repeats. got7fsn_ti ribosomal DNA maintenance|rDNA maintenance biological_process owl:Class
GO:0008595 biolink:NamedThing anterior/posterior axis specification, embryo The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. got7fsn_ti anterior/posterior axis determination, embryo biological_process owl:Class
GO:0009948 biolink:NamedThing anterior/posterior axis specification The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. got7fsn_ti anterior/posterior axis determination biological_process owl:Class
GO:0003021 biolink:NamedThing detection of increased carbon dioxide by chemoreceptor signaling The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. got7fsn_ti detection of increased carbon dioxide by chemoreceptor signalling biological_process owl:Class
GO:0003031 biolink:NamedThing detection of carbon dioxide The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0043731 biolink:NamedThing 6-hydroxynicotinate 3-monooxygenase activity Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD. got7fsn_ti RHEA:27333|EC:1.14.13.114|MetaCyc:RXN-7573 molecular_function owl:Class
GO:0052751 biolink:NamedThing GDP-mannose hydrolase activity Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate. got7fsn_ti GDP-mannose pyrophosphatase activity ai 2011-09-21T04:11:30Z molecular_function owl:Class
GO:0016462 biolink:NamedThing pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments. got7fsn_ti Reactome:R-HSA-6810472 molecular_function owl:Class
GO:0031709 biolink:NamedThing gastrin-releasing peptide receptor binding Binding to a gastrin-releasing peptide receptor. got7fsn_ti GRP receptor binding|gastrin-releasing peptide receptor ligand molecular_function owl:Class
GO:0031705 biolink:NamedThing bombesin receptor binding Binding to a bombesin receptor. got7fsn_ti bombesin receptor ligand molecular_function owl:Class
GO:0019702 biolink:NamedThing protein-arginine N5-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine. got7fsn_ti type IV protein arginine methyltransferase activity|protein-arginine delta-N-methyltransferase activity|type IV PRMT activity|S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming) This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. EC:2.1.1.322|RHEA:48116 molecular_function owl:Class
GO:0097306 biolink:NamedThing cellular response to alcohol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus. got7fsn_ti pr 2012-05-15T03:49:51Z biological_process owl:Class
GO:0140527 biolink:NamedThing reciprocal homologous recombination A DNA recombination process that results in the bidirectional exchange of genetic material between highly homologous DNA molecules. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18777 pg 2020-09-29T15:08:11Z biological_process owl:Class
GO:0035825 biolink:NamedThing homologous recombination A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules. got7fsn_ti chromosomal crossover|interstrand DNA recombination|reciprocal DNA recombination|interchromosomal DNA recombination https://github.com/geneontology/go-ontology/issues/18777 bf 2011-05-04T01:23:31Z Wikipedia:Chromosomal_crossover biological_process owl:Class
GO:0047945 biolink:NamedThing L-glutamine:pyruvate aminotransferase activity Catalysis of the reaction: L-glutamine + pyruvate = 2-oxoglutaramate + L-alanine. got7fsn_ti glutamine--pyruvate aminotransferase activity|glutamine-alpha-keto acid transamidase activity|glutaminase II activity|glutamine transaminase L activity|L-glutamine transaminase L|glutamine-alpha-keto acid transaminase activity|glutamine--oxo-acid transaminase activity|gamma-glutaminyltransferase activity|glutamine-oxo acid aminotransferase activity|glutamine transaminase activity|glutamine-pyruvate transaminase activity|glutamine-keto acid aminotransferase activity KEGG_REACTION:R00576|RHEA:10400|EC:2.6.1.15|Reactome:R-HSA-893616|MetaCyc:GLUTAMINE--PYRUVATE-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:0070548 biolink:NamedThing L-glutamine aminotransferase activity Catalysis of the transfer of an amino group from L-glutamine to an acceptor, usually a 2-oxo acid. got7fsn_ti molecular_function owl:Class
GO:0000952 biolink:NamedThing aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. got7fsn_ti biological_process owl:Class
GO:0009074 biolink:NamedThing aromatic amino acid family catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). got7fsn_ti aromatic amino acid family degradation|aromatic amino acid family breakdown|aromatic amino acid family catabolism biological_process owl:Class
GO:0140061 biolink:NamedThing 5-hydroxymethylcytosine dioxygenase activity Catalysis of the reaction: 5-hydroxymethylcytosine + 2-oxoglutarate + O2 = 5-formylcytosine + succinate + CO2. got7fsn_ti 5hmC dioxygenase pg 2017-07-20T09:54:50Z molecular_function owl:Class
GO:0031511 biolink:NamedThing Mis6-Sim4 complex A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human. got7fsn_ti Mis6 centromere subcomplex|Mis6-Mal2-Sim4 centromere complex|Sim4 complex cellular_component owl:Class
GO:0033701 biolink:NamedThing dTDP-galactose 6-dehydrogenase activity Catalysis of the reaction: dTDP-D-galactose + 2 NADP+ + H2O = dTDP-D-galacturonate + 2 NADPH + 2 H+. got7fsn_ti thymidine-diphosphate-galactose dehydrogenase activity|dTDPgalactose 6-dehydrogenase activity|dTDP-D-galactose:NADP+ 6-oxidoreductase activity RHEA:12396|MetaCyc:DTDP-GALACTOSE-6-DEHYDROGENASE-RXN|EC:1.1.1.186 molecular_function owl:Class
GO:0046902 biolink:NamedThing regulation of mitochondrial membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. got7fsn_ti regulation of mitochondrial envelope permeability|regulation of transport across mitochondrial membrane biological_process owl:Class
GO:0044777 biolink:NamedThing single-stranded DNA-binding protein complex A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair. got7fsn_ti SSB complex jl 2013-03-14T13:14:00Z cellular_component owl:Class
GO:0010018 biolink:NamedThing far-red light signaling pathway The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti far red light signalling pathway|far-red light signal transduction|far red signaling pathway biological_process owl:Class
GO:0010017 biolink:NamedThing red or far-red light signaling pathway The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti red/far red light signaling pathway|red or far-red light signalling pathway|red or far-red light signal transduction|phytochrome signaling pathway|red or far red light signaling pathway biological_process owl:Class
GO:0048165 biolink:NamedThing fused antrum stage The stage in oogenesis when the antral spaces fuse to form a single antral space. The oocyte is suspended in the cumulus oophorous and the first polar body in the perivitelline space. got7fsn_ti mammalian oogenesis stage 8 biological_process owl:Class
GO:0061666 biolink:NamedThing UFM1 ligase activity Catalysis of the transfer of UFM1 to a substrate protein via the reaction X-UFM1 + S --> X + S-UFM1, where X is either an E2 or E3 enzyme, the X-UFM1 linkage is a thioester bond, and the S-UFM1 linkage is an isopeptide bond between the C-terminal amino acid of UFM1 and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T14:02:37Z molecular_function owl:Class
GO:0050165 biolink:NamedThing pantetheine kinase activity Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate. got7fsn_ti pantetheine kinase (phosphorylating)|ATP:pantetheine 4'-phosphotransferase activity RHEA:22472|MetaCyc:PANTETHEINE-KINASE-RXN|EC:2.7.1.34 molecular_function owl:Class
GO:0072147 biolink:NamedThing glomerular parietal epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. got7fsn_ti Bowman's capsule cell fate commitment mah 2010-02-24T02:00:52Z biological_process owl:Class
GO:0072314 biolink:NamedThing glomerular epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. got7fsn_ti mah 2010-04-09T07:02:25Z biological_process owl:Class
GO:0014882 biolink:NamedThing regulation of myofibril number Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. got7fsn_ti change of myofibril number biological_process owl:Class
GO:0014738 biolink:NamedThing regulation of muscle hyperplasia Any process that modulates the frequency, rate or extent of muscle hyperplasia. got7fsn_ti biological_process owl:Class
GO:0033379 biolink:NamedThing maintenance of protease location in T cell secretory granule A process in which a protease is maintained in a secretory granule in a T cell and prevented from moving elsewhere. got7fsn_ti maintenance of protease localization in T lymphocyte secretory granule|maintenance of protease localization in T-cell secretory granule|maintenance of protease localization in T-lymphocyte secretory granule|maintenance of protease localization in T cell secretory granule biological_process owl:Class
GO:0033377 biolink:NamedThing maintenance of protein location in T cell secretory granule A process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere. got7fsn_ti maintenance of protein localization in T lymphocyte secretory granule|maintenance of protein localization in T cell secretory granule|maintenance of protein localization in T-cell secretory granule|maintenance of protein localization in T-lymphocyte secretory granule biological_process owl:Class
GO:0031746 biolink:NamedThing type 1 cysteinyl leukotriene receptor binding Binding to a type 1 cysteinyl leukotriene receptor. got7fsn_ti type 1 cysteinyl leukotriene receptor ligand molecular_function owl:Class
GO:0031745 biolink:NamedThing cysteinyl leukotriene receptor binding Binding to a cysteinyl leukotriene receptor. got7fsn_ti cysteinyl leukotriene receptor ligand molecular_function owl:Class
GO:0008241 biolink:NamedThing peptidyl-dipeptidase activity Catalysis of the release of C-terminal dipeptides from a polypeptide chain. got7fsn_ti EC:3.4.15.- molecular_function owl:Class
GO:0042383 biolink:NamedThing sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. got7fsn_ti Wikipedia:Sarcolemma cellular_component owl:Class
GO:0005886 biolink:NamedThing plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. got7fsn_ti cell membrane|bacterial inner membrane|plasma membrane lipid bilayer|cytoplasmic membrane|plasmalemma|juxtamembrane|inner endospore membrane|cellular membrane GO:0005904 Wikipedia:Cell_membrane|NIF_Subcellular:sao1663586795 cellular_component owl:Class
GO:0072688 biolink:NamedThing SHREC complex localization Any process in which a SHREC complex is transported to, or maintained in, a specific location. got7fsn_ti SHREC complex localisation|establishment and maintenance of SHREC complex localization mah 2011-07-20T12:51:49Z biological_process owl:Class
GO:0032351 biolink:NamedThing negative regulation of hormone metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone. got7fsn_ti downregulation of hormone metabolic process|negative regulation of hormone metabolism|down-regulation of hormone metabolic process|down regulation of hormone metabolic process|inhibition of hormone metabolic process biological_process owl:Class
GO:0002637 biolink:NamedThing regulation of immunoglobulin production Any process that modulates the frequency, rate, or extent of immunoglobulin production. got7fsn_ti regulation of immunoglobulin secretion|regulation of immunoglobulin biosynthetic process|regulation of antibody production GO:0002640|GO:0051023 biological_process owl:Class
GO:0002032 biolink:NamedThing desensitization of G protein-coupled receptor signaling pathway by arrestin The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins. got7fsn_ti arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway|arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway biological_process owl:Class
GO:0032091 biolink:NamedThing negative regulation of protein binding Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding. got7fsn_ti downregulation of protein binding|down-regulation of protein binding|inhibition of protein binding|down regulation of protein binding biological_process owl:Class
GO:0030018 biolink:NamedThing Z disc Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. got7fsn_ti Z disk|Z band|Z line cellular_component owl:Class
GO:0003987 biolink:NamedThing acetate-CoA ligase activity Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. got7fsn_ti ACS|acetyl-CoA synthetase activity|acetyl CoA ligase activity|acyl-activating enzyme activity|acetyl activating enzyme|acetate thiokinase activity|acetyl-CoA synthase activity|acetyl coenzyme A synthetase activity|acetic thiokinase activity|acetate to acetyl-CoA|short-chain acyl-coenzyme A synthetase activity|acetyl-coenzyme A synthase activity|acetyl-activating enzyme activity|short chain fatty acyl-CoA synthetase activity|acetate:CoA ligase (AMP-forming)|acetyl CoA synthase activity Reactome:R-HSA-71735|Reactome:R-HSA-8875071|Reactome:R-HSA-449911|RHEA:23176|EC:6.2.1.1|MetaCyc:ACETATE--COA-LIGASE-RXN molecular_function owl:Class
GO:0035989 biolink:NamedThing tendon development The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force. got7fsn_ti sinew development bf 2011-08-26T04:14:30Z biological_process owl:Class
GO:0061448 biolink:NamedThing connective tissue development The progression of a connective tissue over time, from its formation to the mature structure. got7fsn_ti dph 2012-03-22T12:53:41Z biological_process owl:Class
GO:0036348 biolink:NamedThing hydantoin racemase activity Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin. got7fsn_ti bf 2012-09-19T10:47:56Z MetaCyc:RXN-9781|RHEA:46624|KEGG_REACTION:R09704|EC:5.1.99.5 molecular_function owl:Class
GO:0016854 biolink:NamedThing racemase and epimerase activity Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. got7fsn_ti racemase and epimerase activity, acting on other compounds Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound. EC:5.1.-.- molecular_function owl:Class
GO:0001595 biolink:NamedThing angiotensin receptor activity Combining with angiotensin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0030320 biolink:NamedThing cellular monovalent inorganic anion homeostasis Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell. got7fsn_ti biological_process owl:Class
GO:0055083 biolink:NamedThing monovalent inorganic anion homeostasis Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0031497 biolink:NamedThing chromatin assembly The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. got7fsn_ti establishment of chromatin architecture|chromatin maintenance biological_process owl:Class
GO:0003093 biolink:NamedThing regulation of glomerular filtration Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule. got7fsn_ti biological_process owl:Class
GO:0000839 biolink:NamedThing Hrd1p ubiquitin ligase ERAD-L complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. got7fsn_ti cellular_component owl:Class
GO:0000836 biolink:NamedThing Hrd1p ubiquitin ligase complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78). got7fsn_ti HRD1 ubiquitin ligase complex cellular_component owl:Class
GO:0061196 biolink:NamedThing fungiform papilla development The progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue. got7fsn_ti dph 2010-07-27T12:23:48Z biological_process owl:Class
GO:0035502 biolink:NamedThing metanephric part of ureteric bud development The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros. got7fsn_ti bf 2010-04-29T03:22:21Z biological_process owl:Class
GO:0035295 biolink:NamedThing tube development The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts. got7fsn_ti biological_process owl:Class
GO:0060513 biolink:NamedThing prostatic bud formation The morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. got7fsn_ti primary prostate bud formation|prostate gland formation|prostate ductal budding biological_process owl:Class
GO:0035783 biolink:NamedThing CD4-positive, alpha-beta T cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation. got7fsn_ti CD4-positive, alpha beta T cell costimulation bf 2011-04-04T11:28:52Z biological_process owl:Class
GO:2000516 biolink:NamedThing positive regulation of CD4-positive, alpha-beta T cell activation Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation. got7fsn_ti ebc 2011-03-22T10:37:06Z biological_process owl:Class
GO:0106069 biolink:NamedThing synapsis initiation complex A SUMO-E3 ligase complex capable of promoting synapsis, the meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. got7fsn_ti hjd 2017-11-22T18:50:26Z cellular_component owl:Class
GO:0106068 biolink:NamedThing SUMO ligase complex A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex. got7fsn_ti SUMO transferase complex|SUMO-protein ligase complex|Sumoylation complex hjd 2017-11-22T18:46:00Z cellular_component owl:Class
GO:0009606 biolink:NamedThing tropism The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it. got7fsn_ti Wikipedia:Tropism biological_process owl:Class
GO:0140395 biolink:NamedThing averantin hydroxylase activity Catalyzes the reaction: (1'S)-averantin + [reduced NADPH--hemoprotein reductase] + O(2) <=> (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH--hemoprotein reductase] + H(2)O. Involved in aflatoxin biosynthesis. got7fsn_ti pg 2019-11-29T08:48:23Z MetaCyc:RXN-9482|RHEA:35575|EC:1.14.14.116 molecular_function owl:Class
GO:0036422 biolink:NamedThing heptaprenyl diphosphate synthase activity Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate. got7fsn_ti heptaprenyl pyrophosphate synthase activity|HepPP synthase activity|all-trans-heptaprenyl-diphosphate synthase activity|heptaprenyl pyrophosphate synthetase activity bf 2013-09-16T11:50:41Z RHEA:27794|MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN|EC:2.5.1.30 molecular_function owl:Class
GO:0032299 biolink:NamedThing ribonuclease H2 complex A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p. got7fsn_ti RNase H2 complex cellular_component owl:Class
GO:0035335 biolink:NamedThing peptidyl-tyrosine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine. got7fsn_ti bf 2010-03-01T01:09:14Z biological_process owl:Class
GO:0006470 biolink:NamedThing protein dephosphorylation The process of removing one or more phosphoric residues from a protein. got7fsn_ti protein amino acid dephosphorylation biological_process owl:Class
GO:0050963 biolink:NamedThing detection of electrical stimulus involved in sensory perception The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception. got7fsn_ti sensory detection of electrical stimulus during sensory perception|sensory perception, sensory transduction of electrical stimulus|sensory transduction of electrical stimulus|sensory perception, sensory detection of electrical stimulus|sensory transduction of electrical stimulus during sensory perception|sensory detection of electrical stimulus biological_process owl:Class
GO:0019569 biolink:NamedThing L-arabinose catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate. got7fsn_ti L-arabinose degradation to xylulose 5-phosphate|L-arabinose breakdown to xylulose 5-phosphate MetaCyc:ARABCAT-PWY biological_process owl:Class
GO:0004164 biolink:NamedThing diphthine synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. got7fsn_ti diphthine methyltransferase activity|S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity|S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity RHEA:20145|MetaCyc:RXN-11370|EC:2.1.1.98|Reactome:R-HSA-5358484 molecular_function owl:Class
GO:0009940 biolink:NamedThing amino-terminal vacuolar sorting propeptide binding Binding to an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles. got7fsn_ti molecular_function owl:Class
GO:0010209 biolink:NamedThing vacuolar sorting signal binding Binding to a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole. got7fsn_ti molecular_function owl:Class
GO:0043409 biolink:NamedThing negative regulation of MAPK cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade. got7fsn_ti negative regulation of mitogen activated protein kinase cascade|negative regulation of MAPKKK cascade|down regulation of MAPKKK cascade|negative regulation of mitogen-activated protein kinase cascade|negative regulation of MAP kinase cascade|negative regulation of mitogen-activated protein kinase kinase kinase cascade|negative regulation of mitogen activated protein kinase kinase kinase cascade|inhibition of MAPKKK cascade|negative regulation of MAP kinase kinase kinase cascade|down-regulation of MAPKKK cascade|downregulation of MAPKKK cascade|down regulation of MAPK cascade|inhibition of MAPK cascade|downregulation of MAPK cascade|down-regulation of MAPK cascade biological_process owl:Class
GO:1902532 biolink:NamedThing negative regulation of intracellular signal transduction Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction. got7fsn_ti down regulation of signal transduction via intracellular signaling cascade|negative regulation of intracellular protein kinase cascade|down-regulation of signal transduction via intracellular signaling cascade|down regulation of intracellular signaling cascade|inhibition of intracellular signal transduction pathway|downregulation of intracellular signaling pathway|down-regulation of signal transmission via intracellular cascade|down regulation of intracellular signal transduction|inhibition of intracellular signaling chain|down regulation of intracellular signal transduction pathway|inhibition of intracellular signaling pathway|negative regulation of intracellular signaling chain|down-regulation of intracellular signal transduction pathway|downregulation of signal transmission via intracellular cascade|negative regulation of intracellular signaling cascade|downregulation of intracellular signaling chain|negative regulation of intracellular signaling pathway|down-regulation of intracellular signaling cascade|downregulation of signal transduction via intracellular signaling cascade|downregulation of intracellular signaling cascade|negative regulation of signal transduction via intracellular signaling cascade|inhibition of intracellular signal transduction|downregulation of intracellular signal transduction|inhibition of signal transduction via intracellular signaling cascade|inhibition of signal transmission via intracellular cascade|negative regulation of signal transmission via intracellular cascade|down regulation of signal transmission via intracellular cascade|down-regulation of intracellular signaling chain|down-regulation of intracellular signaling pathway|downregulation of intracellular signal transduction pathway|negative regulation of intracellular signal transduction pathway|down regulation of intracellular signaling chain|down regulation of intracellular signaling pathway|inhibition of intracellular signaling cascade|down-regulation of intracellular signal transduction bf 2013-12-02T11:33:01Z GO:0010741 biological_process owl:Class
GO:0098880 biolink:NamedThing maintenance of postsynaptic specialization structure A process which maintains the organization and the arrangement of proteins in the presynaptic specialization. got7fsn_ti biological_process owl:Class
GO:0097106 biolink:NamedThing postsynaptic density organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. got7fsn_ti post synaptic density organization|PSD organization|postsynaptic density organisation|post-synaptic density organization pr 2011-07-27T05:17:12Z biological_process owl:Class
GO:0016234 biolink:NamedThing inclusion body A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers. got7fsn_ti neuronal cytoplasmic inclusion|cellular inclusion NIF_Subcellular:sao120573470|Wikipedia:Inclusion_bodies cellular_component owl:Class
GO:0021627 biolink:NamedThing olfactory nerve morphogenesis The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. got7fsn_ti CN I morphogenesis biological_process owl:Class
GO:0021602 biolink:NamedThing cranial nerve morphogenesis The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions. got7fsn_ti biological_process owl:Class
GO:0036396 biolink:NamedThing RNA N6-methyladenosine methyltransferase complex A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). got7fsn_ti WMM complex|METTL3-METTL14-WTAP methyltransferase complex|MIS complex|Mum2, Ime4, and Slz1 complex|m6A methyltransferase complex|m(6)A writer complex bf 2013-07-15T10:17:50Z cellular_component owl:Class
GO:0034708 biolink:NamedThing methyltransferase complex A protein complex that possesses methyltransferase activity. got7fsn_ti cellular_component owl:Class
GO:0060740 biolink:NamedThing prostate gland epithelium morphogenesis The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube. got7fsn_ti dph 2009-06-16T09:23:22Z biological_process owl:Class
GO:0005749 biolink:NamedThing mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. got7fsn_ti mitochondrial fumarate reductase complex GO:0009362|GO:0008136|GO:0019738|GO:0030390 cellular_component owl:Class
GO:0047527 biolink:NamedThing 2,3-dihydroxybenzoate-serine ligase activity Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate + L-serine = products of ATP breakdown + N-(2,3-dihydroxybenzoyl)-L-serine. got7fsn_ti N-(2,3-dihydroxybenzoyl)-serine synthetase activity|2,3-dihydroxybenzoate:L-serine ligase activity|2,3-dihydroxybenzoylserine synthetase activity RHEA:30571|MetaCyc:23-DIHYDROXYBENZOATE--SERINE-LIGASE-RXN|EC:6.3.2.14 molecular_function owl:Class
GO:0060627 biolink:NamedThing regulation of vesicle-mediated transport Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell. got7fsn_ti dph 2009-05-18T02:29:43Z biological_process owl:Class
GO:0000955 biolink:NamedThing amino acid catabolic process via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols. got7fsn_ti biological_process owl:Class
GO:0052746 biolink:NamedThing inositol phosphorylation The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms. got7fsn_ti myo-inositol phosphorylation|inositol and derivative phosphorylation|myo-inositol and derivative phosphorylation ai 2011-09-14T01:55:23Z biological_process owl:Class
GO:0006020 biolink:NamedThing inositol metabolic process The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. got7fsn_ti myo-inositol metabolism|inositol metabolism|myo-inositol metabolic process|vitamin Bh metabolic process|vitamin Bh metabolism Wikipedia:Inositol biological_process owl:Class
GO:0036262 biolink:NamedThing granulysin production The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. bf 2012-06-18T02:11:15Z biological_process owl:Class
GO:0002440 biolink:NamedThing production of molecular mediator of immune response The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti production of cellular mediator of immune response Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0051998 biolink:NamedThing protein carboxyl O-methyltransferase activity Catalysis of the transfer of a methyl group to a carboxyl group on a protein. got7fsn_ti protein carboxyl methyltransferase activity ai 2010-07-20T09:23:00Z molecular_function owl:Class
GO:0097642 biolink:NamedThing calcitonin family receptor activity Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity. got7fsn_ti pr 2014-09-08T15:32:19Z molecular_function owl:Class
GO:0102059 biolink:NamedThing 2-cis,6-cis-farnesyl pyrophosphate synthase activity Catalysis of the reaction: dimethylallyl diphosphate + 2 isopentenyl diphosphate <=> 2 diphosphate + (2Z,6Z)-farnesyl diphosphate. got7fsn_ti neryl-diphosphate:isopentenyl-diphosphate cistransferase activity GO:0102192 RHEA:27810|MetaCyc:RXN-10481|MetaCyc:RXN-11973|EC:2.5.1.92 molecular_function owl:Class
GO:0019620 biolink:NamedThing aerobic benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen. got7fsn_ti aerobic benzoate metabolism biological_process owl:Class
GO:0018874 biolink:NamedThing benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. got7fsn_ti benzoate metabolism UM-BBD_pathwayID:benz2|MetaCyc:P321-PWY biological_process owl:Class
GO:0034924 biolink:NamedThing cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2. got7fsn_ti UM-BBD_reactionID:r0940 molecular_function owl:Class
GO:0097409 biolink:NamedThing glial cytoplasmic inclusion Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy. got7fsn_ti Papp-Lantos body|GCI pr 2012-10-31T13:55:11Z NIF_Subcellular:nlx_subcell_20090703 cellular_component owl:Class
GO:0038157 biolink:NamedThing granulocyte-macrophage colony-stimulating factor signaling pathway A series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors. got7fsn_ti granulocyte-macrophage colony-stimulating factor receptor signaling pathway|granulocyte-macrophage colony-stimulating factor signalling pathway|GM-CSF receptor signaling pathway|GM-CSF signaling pathway|CSF2 signaling pathway bf 2012-05-14T01:22:15Z biological_process owl:Class
GO:0150086 biolink:NamedThing multiple synapse bouton A single axon terminal bouton making contact onto two or more dendritic spines protruding either from a single dendrite or from multiple dendrites. got7fsn_ti multisynapse|multiple spine synapse bouton|MSB|multi-synapse bouton|multi-synapse|multiple synapse|multisynapse bouton|multiple-synapse bouton|multisynaptic bouton|multi-synaptic bouton bc 2018-08-08T13:21:17Z cellular_component owl:Class
GO:0043195 biolink:NamedThing terminal bouton Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. got7fsn_ti bouton|synaptic bouton|terminal button|presynaptic bouton NIF_Subcellular:sao187426937 cellular_component owl:Class
GO:0030844 biolink:NamedThing positive regulation of intermediate filament depolymerization Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization. got7fsn_ti up regulation of intermediate filament depolymerization|positive regulation of intermediate filament polymerization and/or depolymerization|activation of intermediate filament depolymerization|upregulation of intermediate filament depolymerization|up-regulation of intermediate filament depolymerization|stimulation of intermediate filament depolymerization Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841'). biological_process owl:Class
GO:0015374 biolink:NamedThing neutral, basic amino acid:sodium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in). got7fsn_ti neutral, cationic amino acid:sodium:chloride symporter activity molecular_function owl:Class
GO:0005283 biolink:NamedThing amino acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). got7fsn_ti insulin-activated sodium:amino acid transporter activity|threonine/serine:sodium symporter activity|sodium/excitatory amino acid symporter activity|sodium/excitatory amino acid cotransporter activity|insulin-activated sodium/amino acid transporter activity|glutamate/aspartate:sodium symporter activity|sodium:amino acid symporter activity|sodium:amino acid transporter activity|insulin-activated sodium:amino acid symporter activity|isoleucine/valine:sodium symporter activity|sodium/amino acid transporter activity GO:0005285|GO:0005284 molecular_function owl:Class
GO:0002428 biolink:NamedThing antigen processing and presentation of peptide antigen via MHC class Ib The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family. got7fsn_ti peptide antigen processing and presentation via MHC class Ib biological_process owl:Class
GO:0002243 biolink:NamedThing detection of parasitic plant The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0002241 biolink:NamedThing response to parasitic plant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant. got7fsn_ti biological_process owl:Class
GO:0071904 biolink:NamedThing protein N-linked N-acetylgalactosaminylation via asparagine A process of protein N-linked glycosylation via asparagine in which N-acetylgalactosamine is added to the N4 of asparagine, forming an (S)-2-amino-4-(2-acetamido-2-deoxy-beta-D-galactopyranosyl)amino-4-oxobutanoic acid residue. got7fsn_ti protein amino acid N-linked N-acetylgalactosaminylation via asparagine mah 2010-09-15T03:52:28Z RESID:AA0420 biological_process owl:Class
GO:0140670 biolink:NamedThing ATP-dependent cohesin unloading activity Facilitating a conformational change to unload a cohesin complex from sister chromatids, driven by ATP hydrolysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21700 pg 2021-06-24T13:36:05Z molecular_function owl:Class
GO:0140083 biolink:NamedThing ATP-dependent protein-DNA unloading activity Facilitating the removal of a protein or protein complex from a DNA molecule driven by ATP hydrolysis. This can be achieved for example by introducing non-canonical DNA structures or generating torque to directly inhibit a protein-DNA binding interaction. got7fsn_ti protein-DNA unloading ATPase activity https://github.com/geneontology/go-ontology/issues/13992|https://github.com/geneontology/go-ontology/issues/21612 pg 2017-08-08T14:50:27Z molecular_function owl:Class
GO:0034580 biolink:NamedThing 4-methyloctanoyl-CoA dehydrogenase activity Catalysis of the reaction: 4-methyloctanoyl-CoA = 4-methyloct-2-enoyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0924|EC:1.3.99.- molecular_function owl:Class
GO:1990442 biolink:NamedThing intrinsic apoptotic signaling pathway in response to nitrosative stress A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. got7fsn_ti nitrosative stress-induced intrinsic apoptotic signaling pathway|nitrosative stress-induced apoptosis bf 2014-07-31T14:28:16Z biological_process owl:Class
GO:0071500 biolink:NamedThing cellular response to nitrosative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. got7fsn_ti mah 2009-12-18T02:49:46Z biological_process owl:Class
GO:0030658 biolink:NamedThing transport vesicle membrane The lipid bilayer surrounding a transport vesicle. got7fsn_ti constitutive secretory pathway transport vesicle membrane|secretory vesicle membrane cellular_component owl:Class
GO:0030659 biolink:NamedThing cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle. got7fsn_ti cellular_component owl:Class
GO:0031570 biolink:NamedThing DNA integrity checkpoint signaling A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes. got7fsn_ti signal transduction involved in DNA integrity checkpoint|DNA integrity checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072401 biological_process owl:Class
GO:0000075 biolink:NamedThing cell cycle checkpoint signaling A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction. got7fsn_ti G1/S checkpoint|cell cycle checkpoint|G2/M transition checkpoint|signal transduction involved in cell cycle checkpoint|signal transduction involved in G2/M transition checkpoint|G2/M checkpoint|G1/S transition checkpoint https://github.com/geneontology/go-ontology/issues/20935 This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here. GO:0071779|GO:0072407|GO:0072404|GO:0031576|GO:0072395 Wikipedia:Cell_cycle_checkpoint biological_process owl:Class
GO:0072740 biolink:NamedThing cellular response to anisomycin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. got7fsn_ti mah 2012-07-17T10:33:00Z biological_process owl:Class
GO:0072739 biolink:NamedThing response to anisomycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. got7fsn_ti mah 2012-07-17T10:33:00Z biological_process owl:Class
GO:0044621 biolink:NamedThing modulation of cell migration in other organism The process in which an organism effects a change in the process of cell migration in a second organism. got7fsn_ti regulation of cell migration in other organism jl 2012-07-04T04:40:13Z biological_process owl:Class
GO:0035821 biolink:NamedThing modulation of process of other organism The process in which an organism effects a change in the structure or processes of another organism. got7fsn_ti regulation of morphology or physiology of other organism|regulation of physiological process of other organism|modification of morphology or physiology of other organism|regulation of morphology of other organism|regulation of physiology of other organism https://github.com/geneontology/go-ontology/issues/18605 bf 2011-04-21T01:31:51Z biological_process owl:Class
GO:0019232 biolink:NamedThing perception of rate of movement The series of events by which an organism senses the speed and direction of movement of the body and its parts. got7fsn_ti kinesthesia biological_process owl:Class
GO:0019230 biolink:NamedThing proprioception The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors. got7fsn_ti Wikipedia:Proprioception biological_process owl:Class
GO:0002117 biolink:NamedThing amphibian larval development The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form. got7fsn_ti biological_process owl:Class
GO:0035398 biolink:NamedThing helper T cell enhancement of T cell mediated immune response Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell. got7fsn_ti helper T cell enhancement of T cell mediated immunity|provision of T cell help to T cell bf 2010-03-23T10:40:00Z biological_process owl:Class
GO:0035397 biolink:NamedThing helper T cell enhancement of adaptive immune response Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell. got7fsn_ti provision of T cell help bf 2010-03-23T10:38:31Z biological_process owl:Class
GO:0035363 biolink:NamedThing histone locus body A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body. got7fsn_ti HLB bf 2010-03-10T10:44:01Z cellular_component owl:Class
GO:1990578 biolink:NamedThing perinuclear endoplasmic reticulum membrane The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. got7fsn_ti perinuclear ER membrane mcc 2014-12-09T01:13:01Z cellular_component owl:Class
GO:1901615 biolink:NamedThing organic hydroxy compound metabolic process The chemical reactions and pathways involving organic hydroxy compound. got7fsn_ti organic hydroxy compound metabolism pr 2012-11-13T12:54:27Z biological_process owl:Class
GO:0106036 biolink:NamedThing assembly of apicomedial cortex actomyosin A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin. got7fsn_ti hjd 2017-07-12T16:57:06Z biological_process owl:Class
GO:0000475 biolink:NamedThing maturation of 2S rRNA Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0035302 biolink:NamedThing ecdysteroid 25-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods. got7fsn_ti Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22,25-trideoxyecdysone (3-beta,5-beta-ketodiol) to 2,22-dideoxyecdysone (3-beta,5-beta-ketotriol). molecular_function owl:Class
GO:0015488 biolink:NamedThing glucuronide:cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in). got7fsn_ti glucuronide:monovalent cation symporter activity|glucuronoside permease activity molecular_function owl:Class
GO:0015164 biolink:NamedThing glucuronoside transmembrane transporter activity Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. got7fsn_ti glucuronide transporter activity molecular_function owl:Class
GO:0035666 biolink:NamedThing TRIF-dependent toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. got7fsn_ti TRIF-dependent TLR signaling pathway|Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR signaling pathway|TRIF-dependent toll-like receptor signalling pathway bf 2011-02-01T02:35:35Z biological_process owl:Class
GO:0002756 biolink:NamedThing MyD88-independent toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. got7fsn_ti MyD88-independent TLR signaling pathway|MyD88-independent toll-like receptor signalling pathway biological_process owl:Class
GO:0030286 biolink:NamedThing dynein complex Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity. got7fsn_ti cellular_component owl:Class
GO:0018243 biolink:NamedThing protein O-linked glycosylation via threonine The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine. got7fsn_ti protein amino acid O-linked glycosylation via threonine RESID:AA0155 biological_process owl:Class
GO:0006493 biolink:NamedThing protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. got7fsn_ti protein amino acid O-linked glycosylation RESID:AA0154|RESID:AA0153|RESID:AA0212|RESID:AA0155|RESID:AA0157 biological_process owl:Class
GO:0009030 biolink:NamedThing thiamine-phosphate kinase activity Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate. got7fsn_ti thiamin phosphate kinase activity|ATP:thiamine-phosphate phosphotransferase activity|thiamin-phosphate kinase activity|thiamin monophosphokinase activity|thiamin-monophosphate kinase activity|thiamine-monophosphate kinase activity|thiamin monophosphatase activity MetaCyc:THI-P-KIN-RXN|EC:2.7.4.16|RHEA:15913|KEGG_REACTION:R00617 molecular_function owl:Class
GO:0001922 biolink:NamedThing B-1 B cell homeostasis The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. got7fsn_ti B-1 B-cell homeostasis|B-1 B lymphocyte homeostasis|B-1 B-lymphocyte homeostasis Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. biological_process owl:Class
GO:0001782 biolink:NamedThing B cell homeostasis The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti B-lymphocyte homeostasis|B lymphocyte homeostasis|B-cell homeostasis Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. biological_process owl:Class
GO:0035301 biolink:NamedThing Hedgehog signaling complex A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila). got7fsn_ti Hedgehog signalling complex|HSC cellular_component owl:Class
GO:0044273 biolink:NamedThing sulfur compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. got7fsn_ti sulfur catabolism|sulfur compound degradation|sulfur compound breakdown|sulfur compound catabolism|sulfur catabolic process biological_process owl:Class
GO:0033378 biolink:NamedThing establishment of protease localization to T cell secretory granule The directed movement of a protease to a location within a secretory granule in a T cell. got7fsn_ti establishment of protease localization in T cell secretory granule|establishment of protease localization in T lymphocyte secretory granule|establishment of protease localisation in T cell secretory granule|establishment of protease localization in T-cell secretory granule|establishment of protease localization in T-lymphocyte secretory granule biological_process owl:Class
GO:0033376 biolink:NamedThing establishment of protein localization to T cell secretory granule The directed movement of a protein to a location within a secretory granule in a T cell. got7fsn_ti establishment of protein localization in T lymphocyte secretory granule|establishment of protein localisation in T cell secretory granule|establishment of protein localization in T cell secretory granule|establishment of protein localization in T-lymphocyte secretory granule|establishment of protein localization in T-cell secretory granule biological_process owl:Class
GO:0008445 biolink:NamedThing D-aspartate oxidase activity Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide. got7fsn_ti aspartic oxidase activity|D-aspartic oxidase activity|D-aspartate:oxygen oxidoreductase (deaminating) MetaCyc:D-ASPARTATE-OXIDASE-RXN|EC:1.4.3.1|RHEA:12512|Reactome:R-HSA-6810076 molecular_function owl:Class
GO:0015922 biolink:NamedThing aspartate oxidase activity Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide. got7fsn_ti molecular_function owl:Class
GO:0030164 biolink:NamedThing protein denaturation Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds. got7fsn_ti Wikipedia:Denaturation#Protein_denaturation biological_process owl:Class
GO:0044257 biolink:NamedThing cellular protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by individual cells. got7fsn_ti cellular protein breakdown|cellular protein degradation|cellular protein catabolism biological_process owl:Class
GO:0016574 biolink:NamedThing histone ubiquitination The modification of histones by addition of ubiquitin groups. got7fsn_ti histone ubiquitinylation|histone ubiquitylation biological_process owl:Class
GO:0140325 biolink:NamedThing negative regulation of protein localization to medial cortex Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex. got7fsn_ti pg 2019-04-17T11:58:27Z biological_process owl:Class
GO:1903077 biolink:NamedThing negative regulation of protein localization to plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane. got7fsn_ti downregulation of protein localization to plasma membrane|negative regulation of establishment of protein localization to plasma membrane|down regulation of protein targeting to plasma membrane|downregulation of protein localization in plasma membrane|downregulation of protein targeting to plasma membrane|down-regulation of protein localization to plasma membrane|negative regulation of protein-plasma membrane targeting|down regulation of protein localization to plasma membrane|inhibition of protein localization in plasma membrane|down-regulation of protein localisation in plasma membrane|down regulation of protein localisation in plasma membrane|downregulation of protein-plasma membrane targeting|inhibition of protein targeting to plasma membrane|negative regulation of protein localisation in plasma membrane|inhibition of protein-plasma membrane targeting|negative regulation of establishment of protein localisation in plasma membrane|negative regulation of protein localization in plasma membrane|negative regulation of protein targeting to plasma membrane|down-regulation of protein localization in plasma membrane|down-regulation of protein-plasma membrane targeting|inhibition of protein localisation in plasma membrane|negative regulation of establishment of protein localization in plasma membrane|down-regulation of protein targeting to plasma membrane|down regulation of protein-plasma membrane targeting|inhibition of protein localization to plasma membrane|down regulation of protein localization in plasma membrane|downregulation of protein localisation in plasma membrane tb 2014-05-29T17:10:16Z GO:0090005|GO:1905964 biological_process owl:Class
GO:0047266 biolink:NamedThing poly(ribitol-phosphate) beta-glucosyltransferase activity Catalysis of the reaction: poly(ribitol phosphate) + UDP-D-glucose = beta-D-glucosylpoly(ribitol phosphate) + UDP. got7fsn_ti UDP-glucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity|UDP-D-glucose polyribitol phosphate glucosyl transferase activity|uridine diphosphoglucose-poly(ribitol-phosphate) beta-glucosyltransferase activity|UDP-D-glucose:polyribitol phosphate glucosyl transferase activity|UDPglucose:poly(ribitol-phosphate) beta-D-glucosyltransferase activity|UDP glucose-poly(ribitol-phosphate) beta-glucosyltransferase activity EC:2.4.1.53|MetaCyc:2.4.1.53-RXN|RHEA:10068 molecular_function owl:Class
GO:0071516 biolink:NamedThing establishment of imprinting at mating-type locus The initial formation of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication. got7fsn_ti mating type determination, establishment of imprinting mah 2010-01-06T01:16:27Z biological_process owl:Class
GO:0033039 biolink:NamedThing salty taste receptor activity Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste. got7fsn_ti molecular_function owl:Class
GO:0002791 biolink:NamedThing regulation of peptide secretion Any process that modulates the frequency, rate, or extent of peptide secretion. got7fsn_ti biological_process owl:Class
GO:0051046 biolink:NamedThing regulation of secretion Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. got7fsn_ti biological_process owl:Class
GO:0030143 biolink:NamedThing COPI-coated inter-Golgi transport vesicle A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack). got7fsn_ti inter-Golgi transport constitutive secretory pathway transport vesicle GO:0005807 NIF_Subcellular:sao1382918459 cellular_component owl:Class
GO:0030133 biolink:NamedThing transport vesicle Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell. got7fsn_ti Golgi-vacuole transport vesicle|Golgi to vacuole transport vesicle|secretory vesicle|constitutive secretory pathway transport vesicle Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. NIF_Subcellular:sao885490876 cellular_component owl:Class
GO:0102752 biolink:NamedThing 1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) Catalysis of the reaction: a glucosylated glycogenin = a glycogen. got7fsn_ti MetaCyc:RXN-7669|EC:2.4.1.18 molecular_function owl:Class
GO:0009610 biolink:NamedThing response to symbiotic fungus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism. got7fsn_ti response to symbiotic fungi biological_process owl:Class
GO:0009608 biolink:NamedThing response to symbiont Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti response of host to symbiont biological_process owl:Class
GO:0044283 biolink:NamedThing small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. got7fsn_ti small molecule biosynthesis Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. jl 2010-01-26T12:06:49Z biological_process owl:Class
GO:0009058 biolink:NamedThing biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. got7fsn_ti formation|anabolism|multicellular organismal biosynthetic process|single-organism biosynthetic process|biosynthesis|synthesis jl 2012-10-17T15:52:18Z GO:0044711|GO:0044274 Wikipedia:Anabolism biological_process owl:Class
GO:0072520 biolink:NamedThing seminiferous tubule development The reproductive developmental process whose specific outcome is the progression of the seminiferous tubule over time, from its formation to the mature structure. Seminiferous tubules are ducts located in the testicles, and are the specific location of meiosis, and the subsequent creation of gametes, namely spermatozoa. got7fsn_ti mah 2011-01-04T12:50:36Z biological_process owl:Class
GO:2000872 biolink:NamedThing positive regulation of progesterone secretion Any process that activates or increases the frequency, rate or extent of progesterone secretion. got7fsn_ti bf 2011-07-26T08:51:22Z biological_process owl:Class
GO:0010087 biolink:NamedThing phloem or xylem histogenesis The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana. got7fsn_ti vascular tissue development|vascular tissue histogenesis biological_process owl:Class
GO:0062119 biolink:NamedThing LinE complex A protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins. got7fsn_ti dph 2019-03-19T14:00:26Z cellular_component owl:Class
GO:0050373 biolink:NamedThing UDP-arabinose 4-epimerase activity Catalysis of the reaction: UDP-L-arabinose = UDP-alpha-D-xylose. got7fsn_ti UDP arabinose epimerase activity|UDParabinose 4-epimerase activity|UDP-D-xylose 4-epimerase activity|UDP-D-xylose-4-epimerase activity|uridine diphosphoarabinose epimerase activity|uridine 5'-diphosphate-D-xylose 4-epimerase activity|UDP-L-arabinose 4-epimerase activity KEGG_REACTION:R01473|MetaCyc:UDP-ARABINOSE-4-EPIMERASE-RXN|EC:5.1.3.5|RHEA:11320 molecular_function owl:Class
GO:0102445 biolink:NamedThing 3-methylquercetin 3'-O-methyltransferase activity Catalysis of the reaction: 3',4',5-trihydroxy-3-methoxyflavon-7-olate + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13930 molecular_function owl:Class
GO:0071285 biolink:NamedThing cellular response to lithium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. got7fsn_ti mah 2009-12-10T04:04:13Z biological_process owl:Class
GO:0071248 biolink:NamedThing cellular response to metal ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. got7fsn_ti cellular response to heavy metal|cellular response to metal mah 2009-12-03T02:46:31Z biological_process owl:Class
GO:0044581 biolink:NamedThing butyryl-CoA catabolic process to butyrate The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate. got7fsn_ti butyryl-CoA catabolism to butyrate jl 2012-04-19T04:29:40Z biological_process owl:Class
GO:0044580 biolink:NamedThing butyryl-CoA catabolic process The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA. got7fsn_ti butyryl-CoA catabolism jl 2012-04-19T04:28:46Z biological_process owl:Class
GO:0015344 biolink:NamedThing siderophore uptake transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). got7fsn_ti siderochrome-iron (ferrioxamine) uptake transporter|ferrioxamine uptake transmembrane transporter activity|siderophore-iron uptake transmembrane transporter activity molecular_function owl:Class
GO:0015343 biolink:NamedThing siderophore transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). got7fsn_ti siderophore-iron transporter activity|siderophore-iron transmembrane transporter activity|siderophore transporter activity|iron-siderophore transporter activity|siderochrome-iron transporter activity|siderochrome transporter activity GO:0042927|GO:0015236|GO:0015237 Reactome:R-HSA-1222597 molecular_function owl:Class
GO:1990941 biolink:NamedThing mitotic spindle kinetochore microtubule Any of the mitotic spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic chromosome segregation. got7fsn_ti vw 2016-04-06T13:31:38Z cellular_component owl:Class
GO:0051718 biolink:NamedThing DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Catalysis of the reaction: S-adenosyl-L-methionine + CpG (in DNA) = S-adenosyl-L-homocysteine + 5-MeCpG (in DNA). got7fsn_ti M.BsuRIb|HpaII methylase|M.BsuRIa|HpaII' methylase Reactome:R-HSA-5334151 molecular_function owl:Class
GO:0000409 biolink:NamedThing regulation of transcription by galactose Any process involving galactose that modulates the frequency, rate or extent or transcription. got7fsn_ti biological_process owl:Class
GO:0006355 biolink:NamedThing regulation of transcription, DNA-templated Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. got7fsn_ti regulation of transcription, DNA-dependent|regulation of gene-specific transcription|regulation of cellular transcription, DNA-dependent|transcriptional control GO:0045449|GO:0032583|GO:0061019 biological_process owl:Class
GO:0106281 biolink:NamedThing chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity Catalysis of the reaction: chenodeoxycholate + NAD(+) = 7-oxolithocholate + H(+) + NADH. got7fsn_ti hjd 2020-07-29T17:48:25Z RHEA:42036 molecular_function owl:Class
GO:1903302 biolink:NamedThing regulation of pyruvate kinase activity Any process that modulates the frequency, rate or extent of pyruvate kinase activity. got7fsn_ti regulation of phosphoenolpyruvate kinase activity|regulation of phosphoenol transphosphorylase activity|regulation of ATP:pyruvate 2-O-phosphotransferase activity mr 2014-08-15T23:25:51Z biological_process owl:Class
GO:0051338 biolink:NamedThing regulation of transferase activity Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. got7fsn_ti transferase regulator This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. biological_process owl:Class
GO:0060951 biolink:NamedThing neural crest-derived cardiac glial cell differentiation The process in which a neural crest cell acquires the specialized features of a glial cell of the heart. got7fsn_ti dph 2009-09-29T03:08:06Z biological_process owl:Class
GO:0060950 biolink:NamedThing cardiac glial cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart. got7fsn_ti dph 2009-09-29T03:06:37Z biological_process owl:Class
GO:0097074 biolink:NamedThing interferon regulatory factor 7 complex An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7. got7fsn_ti IRF7:IRF7 complex pr 2011-06-15T04:31:04Z cellular_component owl:Class
GO:0097071 biolink:NamedThing interferon regulatory factor complex A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. got7fsn_ti IRF complex pr 2011-06-15T04:22:30Z cellular_component owl:Class
GO:0071499 biolink:NamedThing cellular response to laminar fluid shear stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. got7fsn_ti mah 2009-12-18T02:43:02Z biological_process owl:Class
GO:0071498 biolink:NamedThing cellular response to fluid shear stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. got7fsn_ti mah 2009-12-18T02:41:44Z biological_process owl:Class
GO:0001947 biolink:NamedThing heart looping The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. got7fsn_ti cardiac looping biological_process owl:Class
GO:0003143 biolink:NamedThing embryonic heart tube morphogenesis The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. got7fsn_ti tb 2009-09-22T04:21:17Z biological_process owl:Class
GO:0010020 biolink:NamedThing chloroplast fission The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis. got7fsn_ti chloroplast division biological_process owl:Class
GO:0009658 biolink:NamedThing chloroplast organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast. got7fsn_ti chloroplast organisation|chloroplast organization and biogenesis biological_process owl:Class
GO:0018163 biolink:NamedThing protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine. got7fsn_ti DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine RESID:AA0254 biological_process owl:Class
GO:0045327 biolink:NamedThing protein-DNA covalent cross-linking via peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue. got7fsn_ti DNA-protein covalent cross-linking via peptidyl-tyrosine biological_process owl:Class
GO:0000433 biolink:NamedThing carbon catabolite repression of transcription from RNA polymerase II promoter by glucose A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. got7fsn_ti down regulation of transcription from RNA polymerase II promoter by glucose|inhibition of transcription from RNA polymerase II promoter by glucose|down-regulation of transcription from RNA polymerase II promoter by glucose|downregulation of transcription from RNA polymerase II promoter by glucose biological_process owl:Class
GO:0045014 biolink:NamedThing carbon catabolite repression of transcription by glucose A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. got7fsn_ti inhibition of transcription by glucose|down-regulation of transcription by glucose|downregulation of transcription by glucose|glucose effect|down regulation of transcription by glucose|glucose repression biological_process owl:Class
GO:0035293 biolink:NamedThing chitin-based larval cuticle pattern formation The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0035017 biolink:NamedThing cuticle pattern formation The regionalization process that gives rise to the patterns of cell differentiation in the cuticle. got7fsn_ti biological_process owl:Class
GO:0044786 biolink:NamedThing cell cycle DNA replication The DNA-dependent DNA replication that takes place as part of the cell cycle. got7fsn_ti jl 2013-05-02T15:52:22Z biological_process owl:Class
GO:0006260 biolink:NamedThing DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. got7fsn_ti DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. GO:0055133 Wikipedia:DNA_replication biological_process owl:Class
GO:0017179 biolink:NamedThing peptidyl-diphthine metabolic process The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue. got7fsn_ti peptidyl-diphthine metabolism biological_process owl:Class
GO:0060007 biolink:NamedThing linear vestibuloocular reflex A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. got7fsn_ti biological_process owl:Class
GO:0060005 biolink:NamedThing vestibular reflex A reflex process in which a response to an angular or linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the inner ear and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. got7fsn_ti biological_process owl:Class
GO:0071670 biolink:NamedThing smooth muscle cell chemotaxis The directed movement of a smooth muscle cell in response to an external stimulus. got7fsn_ti mah 2010-02-16T01:32:59Z biological_process owl:Class
GO:0018537 biolink:NamedThing coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420. got7fsn_ti methylenetetrahydromethanopterin reductase activity|N(5),N(10)-methylenetetrahydromethanopterin reductase activity|N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity|N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity|methylene-H4MPT reductase activity|N5,N10-methylenetetrahydromethanopterin reductase activity|5,10-methylenetetrahydromethanopterin cyclohydrolase activity|5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity|coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity|5,10-methylenetetrahydromethanopterin reductase activity|methylene-H(4)MPT reductase activity KEGG_REACTION:R04464|UM-BBD_reactionID:r0354|RHEA:21144|EC:1.5.98.2|MetaCyc:METHELENE-THMPT-OXI-RXN molecular_function owl:Class
GO:0042994 biolink:NamedThing cytoplasmic sequestering of transcription factor The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. got7fsn_ti transcription factor binding, cytoplasmic sequestering|cytoplasmic storage of transcription factor|sequestration of transcription factor in cytoplasm|sequestering of transcription factor in cytoplasm|retention of transcription factor in cytoplasm|storage of transcription factor in cytoplasm|cytoplasmic retention of transcription factor|maintenance of transcription factor protein location in cytoplasm|cytoplasmic sequestration of transcription factor biological_process owl:Class
GO:0044683 biolink:NamedThing methylthiol:coenzyme M methyltransferase activity Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM. got7fsn_ti methylthiol:coenzyme M methyl transferase activity This reaction is achieved by the catalysis of two successive steps carried out by the same enzyme - the transfer of a methyl group from the substrate to the cobalt cofactor of a methylated-thiol-specific corrinoid protein (MtsB), and the subsequent transfer of the methyl group from the corrinoid protein to coenzyme M. With most other methanogenesis substrates this process is carried out by two different enzymes (for example, EC:2.1.1.90, methanol-corrinoid protein Co-methyltransferase, and EC:2.1.1.246, methylated methanol-specific corrinoid protein:coenzyme M methyltransferase). The cobalt is oxidized during methylation from the Co(I) state to the Co(III) state, and is reduced back to the Co(I) form during demethylation. jl 2012-08-15T11:41:24Z EC:2.1.1.251|MetaCyc:RXN-8125|RHEA:32667 molecular_function owl:Class
GO:0060321 biolink:NamedThing acceptance of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the acceptance of pollen by cells in the stigma. got7fsn_ti acceptance of self pollen|acceptance of non-self pollen biological_process owl:Class
GO:0048544 biolink:NamedThing recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. got7fsn_ti self incompatibility|recognition or rejection of self pollen|pollen recognition GO:0009857 biological_process owl:Class
GO:0060889 biolink:NamedThing limb basal epidermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal basal cell. A epidermal basal cell cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into more specialized cell of the limb epidermis. got7fsn_ti dph 2009-08-13T01:22:12Z biological_process owl:Class
GO:0009913 biolink:NamedThing epidermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis. got7fsn_ti hypodermal cell differentiation GO:0043355 biological_process owl:Class
GO:0048892 biolink:NamedThing lateral line nerve development The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. got7fsn_ti nLL development biological_process owl:Class
GO:0071554 biolink:NamedThing cell wall organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall. got7fsn_ti cellular cell wall organization or biogenesis|cell wall organization or biogenesis at cellular level|cellular cell wall organisation or biogenesis|cell wall organisation or biogenesis mah 2010-01-13T03:19:38Z GO:0070882 biological_process owl:Class
GO:0102209 biolink:NamedThing trans-permethrin hydrolase activity Catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate. got7fsn_ti MetaCyc:RXN-12167|RHEA:30283|EC:3.1.1.88 molecular_function owl:Class
GO:1903575 biolink:NamedThing cornified envelope assembly The aggregation, arrangement and bonding together of a set of components to form a cornified envelope. got7fsn_ti cornified envelope formation An example of this is syntaxin 4 in PMID:22226963. pr 2014-10-28T10:22:49Z biological_process owl:Class
GO:0071709 biolink:NamedThing membrane assembly The aggregation, arrangement and bonding together of a set of components to form a membrane. got7fsn_ti mah 2010-03-10T11:19:17Z biological_process owl:Class
GO:0050361 biolink:NamedThing tryptophan 2-monooxygenase activity Catalysis of the reaction: L-tryptophan + O(2) = CO(2) + H(2)O + indole-3-acetamide. got7fsn_ti L-tryptophan:oxygen 2-oxidoreductase (decarboxylating) RHEA:16165|KEGG_REACTION:R00679|MetaCyc:TRYPTOPHAN-2-MONOOXYGENASE-RXN|EC:1.13.12.3 molecular_function owl:Class
GO:0016703 biolink:NamedThing oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor. got7fsn_ti EC:1.13.12.- molecular_function owl:Class
GO:0019866 biolink:NamedThing organelle inner membrane The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites. got7fsn_ti See also the cellular component term 'outer membrane ; GO:0019867'. cellular_component owl:Class
GO:0031090 biolink:NamedThing organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. got7fsn_ti intracellular membrane NIF_Subcellular:sao830981606 cellular_component owl:Class
GO:0070477 biolink:NamedThing endospore core An intracellular part that represents the innermost portion of an endospore; the endospore core is dehydrated, enriched in dipicolinic acid and divalent cations, and metabolically inactive. got7fsn_ti cellular_component owl:Class
GO:0018892 biolink:NamedThing cyclohexylsulfamate metabolic process The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide. got7fsn_ti cyclohexylsulfamate metabolism|cyclohexylsulphamate metabolic process|cyclohexylsulphamate metabolism UM-BBD_pathwayID:chs biological_process owl:Class
GO:0021833 biolink:NamedThing cell-matrix adhesion involved in tangential migration using cell-cell interactions The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex. got7fsn_ti biological_process owl:Class
GO:0031589 biolink:NamedThing cell-substrate adhesion The attachment of a cell to the underlying substrate via adhesion molecules. got7fsn_ti biological_process owl:Class
GO:0061255 biolink:NamedThing mesonephric glomerular parietal epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. got7fsn_ti dph 2010-08-30T01:33:52Z biological_process owl:Class
GO:0000225 biolink:NamedThing N-acetylglucosaminylphosphatidylinositol deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. got7fsn_ti acetylglucosaminylphosphatidylinositol deacetylase activity|GlcNAc-PI deacetylase activity|N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity|N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity|6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity|GlcNAc-PI de-N-acetylase activity Note that this function was formerly EC:3.1.1.69. EC:3.5.1.89|MetaCyc:3.1.1.69-RXN|Reactome:R-HSA-162857|RHEA:11660 molecular_function owl:Class
GO:0102386 biolink:NamedThing phenylacetaldehyde reductase activity Catalysis of the reaction: 2-phenylethanol + NADP = phenylacetaldehyde + NADPH + H+. got7fsn_ti MetaCyc:RXN-13536 molecular_function owl:Class
GO:0036180 biolink:NamedThing filamentous growth of a population of unicellular organisms in response to biotic stimulus The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus. got7fsn_ti bf 2012-03-30T04:12:40Z biological_process owl:Class
GO:0044182 biolink:NamedThing filamentous growth of a population of unicellular organisms The process in which a group of unicellular organisms grow in a threadlike, filamentous shape. got7fsn_ti jl 2009-09-25T10:18:32Z biological_process owl:Class
GO:0005726 biolink:NamedThing perichromatin fibrils Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts. got7fsn_ti cellular_component owl:Class
GO:0033829 biolink:NamedThing O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity Catalysis of the transfer of a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. got7fsn_ti O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase activity|UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity Reactome:R-HSA-5096538|MetaCyc:2.4.1.222-RXN|EC:2.4.1.222|Reactome:R-HSA-1912355 molecular_function owl:Class
GO:0035263 biolink:NamedThing genital disc sexually dimorphic development The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed. got7fsn_ti biological_process owl:Class
GO:0055119 biolink:NamedThing relaxation of cardiac muscle The process in which the extent of cardiac muscle contraction is reduced. got7fsn_ti biological_process owl:Class
GO:0090075 biolink:NamedThing relaxation of muscle A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain. got7fsn_ti tb 2009-09-11T11:43:38Z biological_process owl:Class
GO:0042589 biolink:NamedThing zymogen granule membrane The lipid bilayer surrounding a zymogen granule. got7fsn_ti cellular_component owl:Class
GO:0048458 biolink:NamedThing floral whorl formation The process that gives rise to the floral whorl. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048415 biological_process owl:Class
GO:0140512 biolink:NamedThing mitotic nuclear bridge midzone The central region of a mitotic nuclear bridge, distal to the main portions of the daughter nuclei. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19946|https://github.com/geneontology/go-ontology/issues/20526 pg 2020-09-07T10:08:02Z cellular_component owl:Class
GO:0003912 biolink:NamedThing DNA nucleotidylexotransferase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). got7fsn_ti TdT|nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity|terminal deoxynucleotidyltransferase activity|terminal deoxynucleotide transferase activity|deoxyribonucleic nucleotidyltransferase activity|addase activity|terminal transferase activity|terminal addition enzyme activity|terminal deoxyribonucleotidyltransferase activity|deoxynucleotidyl terminal transferase activity|deoxyribonucleic acid nucleotidyltransferase activity EC:2.7.7.31|MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN molecular_function owl:Class
GO:0043814 biolink:NamedThing phospholactate guanylyltransferase activity Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate. got7fsn_ti RHEA:30519|EC:2.7.7.68|MetaCyc:RXN-8077 molecular_function owl:Class
GO:0070568 biolink:NamedThing guanylyltransferase activity Catalysis of the transfer of a guanylyl group to an acceptor. got7fsn_ti mah 2009-04-15T11:05:47Z molecular_function owl:Class
GO:0044326 biolink:NamedThing dendritic spine neck Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine. got7fsn_ti pedicle|spine neck|neck jl 2010-08-18T02:31:15Z NIF_Subcellular:sao1642908940 cellular_component owl:Class
GO:1990838 biolink:NamedThing poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P). got7fsn_ti al 2015-08-26T10:24:51Z molecular_function owl:Class
GO:0000175 biolink:NamedThing 3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. got7fsn_ti 3'-5' exoribonuclease activity Reactome:R-HSA-6791227|Reactome:R-HSA-9682603|EC:3.1.13.-|Reactome:R-HSA-9694632|Reactome:R-HSA-6791222|Reactome:R-HSA-430028 molecular_function owl:Class
GO:0018505 biolink:NamedThing cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+. got7fsn_ti cis-dihydrodiol naphthalene dehydrogenase activity|cis-naphthalene dihydrodiol dehydrogenase activity|(+)-cis-naphthalene dihydrodiol dehydrogenase activity|1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity|cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity|naphthalene dihydrodiol dehydrogenase activity MetaCyc:1.3.1.29-RXN|EC:1.3.1.29|UM-BBD_enzymeID:e0122|RHEA:11832 molecular_function owl:Class
GO:0000179 biolink:NamedThing rRNA (adenine-N6,N6-)-dimethyltransferase activity Catalysis of the dimethylation of two adjacent adenine residues in a rRNA, using S-adenosyl-L-methionine as a methyl donor. got7fsn_ti dimethyladenosine transferase activity|S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity|18S rRNA dimethylase activity https://github.com/geneontology/go-ontology/issues/14459 GO:0043790 Reactome:R-HSA-6790994|Reactome:R-HSA-6793066 molecular_function owl:Class
GO:1990831 biolink:NamedThing cellular response to carcinoembryonic antigen Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins. got7fsn_ti cellular response to pregnancy specific glycoprotein sl 2015-08-20T19:43:12Z biological_process owl:Class
GO:1904588 biolink:NamedThing cellular response to glycoprotein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus. got7fsn_ti cellular response to glycoproteins sl 2015-08-20T16:46:30Z biological_process owl:Class
GO:0010589 biolink:NamedThing leaf proximal/distal pattern formation The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis. got7fsn_ti biological_process owl:Class
GO:0009954 biolink:NamedThing proximal/distal pattern formation The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). got7fsn_ti proximal/distal pattern specification biological_process owl:Class
GO:0034700 biolink:NamedThing allulose 6-phosphate 3-epimerase activity Catalysis of the reaction: D-allulose 6-phosphate = D-fructose 6-phosphate. got7fsn_ti MetaCyc:RXN0-304|RHEA:28426 molecular_function owl:Class
GO:0030559 biolink:NamedThing rRNA pseudouridylation guide activity Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0071742 biolink:NamedThing IgE immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:1900576 biolink:NamedThing gerfelin metabolic process The chemical reactions and pathways involving gerfelin. got7fsn_ti gerfelin metabolism di 2012-05-15T06:42:19Z biological_process owl:Class
GO:0031048 biolink:NamedThing heterochromatin assembly by small RNA Assembly of heterochromatin, directed by small RNAs sharing sequence identity to the repressed region. got7fsn_ti chromatin silencing by small RNA|heterochromatin formation involved in chromatin silencing by small RNA|RNA-mediated TGS|heterochromatin assembly involved in chromatin silencing by small RNA|RNAi-directed chromatin silencing|RNA-mediated chromatin silencing|small RNA-mediated heterochromatin formation|RNAi-like chromatin silencing|small RNA-mediated heterochromatic silencing|RNA-mediated transcriptional silencing|RNA interference-like chromatin silencing mah 2009-09-11T04:10:51Z GO:0070924 biological_process owl:Class
GO:0051614 biolink:NamedThing inhibition of serotonin uptake Any process that prevents the activation of the directed movement of serotonin into a cell. got7fsn_ti inhibition of serotonin import|inhibition of 5-HT uptake|inhibition of 5-hydroxytryptamine uptake|inhibition of 5HT uptake biological_process owl:Class
GO:0051609 biolink:NamedThing inhibition of neurotransmitter uptake Any process that prevents the activation of the directed movement of a neurotransmitter into a cell. got7fsn_ti inhibition of neurotransmitter import biological_process owl:Class
GO:0003254 biolink:NamedThing regulation of membrane depolarization Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. got7fsn_ti tb 2009-10-14T10:54:09Z biological_process owl:Class
GO:0014806 biolink:NamedThing smooth muscle hyperplasia A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ. got7fsn_ti biological_process owl:Class
GO:0034322 biolink:NamedThing alcohol O-decanoyltransferase activity Catalysis of the reaction: decanoyl-CoA + an alcohol = CoA + a decyl ester. got7fsn_ti molecular_function owl:Class
GO:0051222 biolink:NamedThing positive regulation of protein transport Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti upregulation of protein transport|up-regulation of protein transport|activation of protein transport|stimulation of protein transport|up regulation of protein transport biological_process owl:Class
GO:0051050 biolink:NamedThing positive regulation of transport Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti up-regulation of transport|stimulation of transport|upregulation of transport|activation of transport|up regulation of transport biological_process owl:Class
GO:0051373 biolink:NamedThing FATZ binding Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. got7fsn_ti filamin-, actinin- and telethonin-binding protein of the Z-disc of striated muscle|FATZ 2 binding|calsarcin 3 binding|calsarcin binding|calsarcin 2 binding|FATZ 1 binding|FATZ 3 binding|calsarcin 1 binding GO:0051374|GO:0051376|GO:0051375 molecular_function owl:Class
GO:0071859 biolink:NamedThing neuropeptide F receptor binding Binding to a neuropeptide F receptor. got7fsn_ti mah 2010-09-10T03:23:56Z molecular_function owl:Class
GO:0031319 biolink:NamedThing detection of cAMP The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP. got7fsn_ti detection of 3',5' cAMP|detection of cyclic AMP|cAMP detection|cyclic AMP detection|3',5'-cAMP sensing|detection of adenosine 3',5'-cyclophosphate|3',5'-cAMP detection|cAMP sensing|detection of 3',5'-cAMP biological_process owl:Class
GO:0102197 biolink:NamedThing vinylacetate caboxylester hydrolase activity Catalysis of the reaction: but-3-enoate + H2O <=> allyl alcohol + formate. got7fsn_ti MetaCyc:RXN-12087 molecular_function owl:Class
GO:0010472 biolink:NamedThing GDP-galactose:glucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: GDP-L-galactose + alpha-D-glucose 1-phosphate = alpha-L-galactose-1-phosphate + GDP-alpha-D-glucose. got7fsn_ti GDP-L-galactose phosphorylase activity|GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity MetaCyc:RXN4FS-13 molecular_function owl:Class
GO:0061375 biolink:NamedThing mammillotectal axonal tract development The progression of the mammillotectal tract over time, from its formation to the mature structure. The mammillotectal tract is the collection of axons that connects the ventral diencephalon to the superior colliculus. got7fsn_ti dph 2010-11-09T09:01:14Z biological_process owl:Class
GO:0034773 biolink:NamedThing histone H4-K20 trimethylation The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone. got7fsn_ti histone H4 K20 trimethylation|histone lysine H4 K20 trimethylation biological_process owl:Class
GO:0018023 biolink:NamedThing peptidyl-lysine trimethylation The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine. got7fsn_ti RESID:AA0074 biological_process owl:Class
GO:0061546 biolink:NamedThing tyramine secretion, neurotransmission The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter. got7fsn_ti dph 2013-06-25T09:16:47Z biological_process owl:Class
GO:0061532 biolink:NamedThing primary amine secretion, neurotransmission The regulated release of a primary amine by a cell, in which the primary amine acts as a neurotransmitter. got7fsn_ti dph 2013-06-21T15:57:12Z biological_process owl:Class
GO:0080009 biolink:NamedThing mRNA methylation The posttranscriptional addition of methyl groups to specific residues in an mRNA molecule. got7fsn_ti biological_process owl:Class
GO:0007131 biolink:NamedThing reciprocal meiotic recombination The cell cycle process in which double strand breaks are formed and repaired through a single or double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. got7fsn_ti female meiotic recombination|gene conversion with reciprocal crossover GO:0000021|GO:0007145 biological_process owl:Class
GO:0090694 biolink:NamedThing Scc2-Scc4 cohesin loading complex A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA. got7fsn_ti Mis4-Ssl3 cohesin loading complex tb 2016-08-24T17:09:11Z cellular_component owl:Class
GO:0032116 biolink:NamedThing SMC loading complex A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved. got7fsn_ti cohesin loading complex|SCC2/SCC4 loading complex|chromatin loading complex cellular_component owl:Class
GO:0032511 biolink:NamedThing late endosome to vacuole transport via multivesicular body sorting pathway The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole. got7fsn_ti endosome to vacuole transport via MVB sorting pathway biological_process owl:Class
GO:0032509 biolink:NamedThing endosome transport via multivesicular body sorting pathway The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment. got7fsn_ti endosome transport via MVB sorting pathway biological_process owl:Class
GO:0016939 biolink:NamedThing kinesin II complex A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes. got7fsn_ti cellular_component owl:Class
GO:0005300 biolink:NamedThing high-affinity tryptophan transmembrane transporter activity Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high-affinity tryptophan transporter activity molecular_function owl:Class
GO:0015196 biolink:NamedThing L-tryptophan transmembrane transporter activity Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. got7fsn_ti L-tryptophan transporter activity|L-tryptophan permease activity|valine/tyrosine/tryptophan permease activity GO:0005299 Reactome:R-HSA-8870352 molecular_function owl:Class
GO:0031640 biolink:NamedThing killing of cells of other organism Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. got7fsn_ti killing of cells of another, non-host, organism|killing of cells of another organism GO:0001908 biological_process owl:Class
GO:0001906 biolink:NamedThing cell killing Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. got7fsn_ti necrosis biological_process owl:Class
GO:0036350 biolink:NamedThing mannose-specific flocculation The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other. got7fsn_ti cell-cell adhesion involved in mannose-specific flocculation bf 2012-09-19T10:57:34Z GO:0098612 biological_process owl:Class
GO:0000128 biolink:NamedThing flocculation The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs. got7fsn_ti cell-cell adhesion involved in flocculation|coflocculation via lectin-mannose interaction|coflocculation|cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction|flocculation via extracellular polymer|flocculation via cell wall protein-carbohydrate interaction|co-flocculation|coflocculation via protein-carbohydrate interaction https://github.com/geneontology/go-ontology/issues/18785|https://github.com/geneontology/go-ontology/issues/20192 The word floc derives from the Latin word floccus, which means a tuft of wool. bf 2012-07-11T01:30:40Z GO:0000501|GO:0032128|GO:0036282|GO:0036281|GO:0043689|GO:0043690 Wikipedia:Flocculation biological_process owl:Class
GO:0051931 biolink:NamedThing regulation of sensory perception Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. got7fsn_ti biological_process owl:Class
GO:0031644 biolink:NamedThing regulation of nervous system process Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system. got7fsn_ti regulation of neurophysiological process|regulation of neurological process|regulation of neurological system process biological_process owl:Class
GO:0030109 biolink:NamedThing HLA-B specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte. got7fsn_ti molecular_function owl:Class
GO:0032396 biolink:NamedThing inhibitory MHC class I receptor activity Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte. got7fsn_ti molecular_function owl:Class
GO:0007206 biolink:NamedThing phospholipase C-activating G protein-coupled glutamate receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). got7fsn_ti activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|metabotropic glutamate receptor, phospholipase C activating pathway|activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway|activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway|phospholipase C-activating G-protein coupled glutamate receptor signaling pathway biological_process owl:Class
GO:0007216 biolink:NamedThing G protein-coupled glutamate receptor signaling pathway A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti metabotropic glutamate receptor signalling pathway|metabotropic glutamate receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway biological_process owl:Class
GO:0060135 biolink:NamedThing maternal process involved in female pregnancy A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. got7fsn_ti biological_process owl:Class
GO:0005766 biolink:NamedThing primary lysosome A lysosome before it has fused with a vesicle or vacuole. got7fsn_ti NIF_Subcellular:sao1140587416 cellular_component owl:Class
GO:0005764 biolink:NamedThing lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. got7fsn_ti Wikipedia:Lysosome|NIF_Subcellular:sao585356902 cellular_component owl:Class
GO:0060890 biolink:NamedThing limb spinous cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal spinous cell. got7fsn_ti dph 2009-08-13T01:31:30Z biological_process owl:Class
GO:0030216 biolink:NamedThing keratinocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. got7fsn_ti keratinocyte cell differentiation biological_process owl:Class
GO:0005980 biolink:NamedThing glycogen catabolic process The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. got7fsn_ti glycogen catabolism|glycogenolysis|glycogen degradation|glycogen breakdown MetaCyc:GLYCOCAT-PWY biological_process owl:Class
GO:0016052 biolink:NamedThing carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. got7fsn_ti carbohydrate degradation|carbohydrate breakdown|carbohydrate catabolism|single-organism carbohydrate catabolic process|catabolic carbohydrate metabolism|multicellular organismal carbohydrate catabolic process|catabolic carbohydrate metabolic process jl 2012-10-23T16:34:39Z GO:0044724|GO:0006095|GO:0044276 biological_process owl:Class
GO:0080022 biolink:NamedThing primary root development The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle. got7fsn_ti biological_process owl:Class
GO:0048364 biolink:NamedThing root development The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo. got7fsn_ti biological_process owl:Class
GO:0016719 biolink:NamedThing carotene 7,8-desaturase activity Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O. got7fsn_ti zeta-carotene desaturase activity|carotene,hydrogen-donor:oxygen oxidoreductase activity EC:1.3.5.6|RHEA:15701|MetaCyc:1.14.99.30-RXN molecular_function owl:Class
GO:0032999 biolink:NamedThing Fc-alpha receptor I complex A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA. got7fsn_ti immunoglobulin A receptor complex|FcaRI complex|IgA receptor complex cellular_component owl:Class
GO:0032997 biolink:NamedThing Fc receptor complex A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin. got7fsn_ti immunoglobulin receptor complex|FcR complex|Fc-receptor complex cellular_component owl:Class
GO:0010381 biolink:NamedThing peroxisome-chloroplast membrane tethering The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. got7fsn_ti attachment of peroxisome to chloroplast biological_process owl:Class
GO:0140056 biolink:NamedThing organelle localization by membrane tethering The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other. got7fsn_ti pg 2017-06-27T09:58:51Z biological_process owl:Class
GO:0002559 biolink:NamedThing type I hypersensitivity mediated by basophils An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. got7fsn_ti biological_process owl:Class
GO:0002560 biolink:NamedThing basophil mediated immunity Any process involved in the carrying out of an immune response by a basophil. got7fsn_ti biological_process owl:Class
GO:0010047 biolink:NamedThing fruit dehiscence The process leading to the spontaneous opening of the fruit permitting the escape of seeds. got7fsn_ti biological_process owl:Class
GO:0080060 biolink:NamedThing integument development The process whose specific outcome is the progression of the integument over time, from its formation to the mature structure. Integument is one of the layers of tissue that usually covers the ovule, enveloping the nucellus and forming the micropyle at the apex. got7fsn_ti dhl 2009-04-13T02:58:07Z biological_process owl:Class
GO:0102194 biolink:NamedThing protein-fructosamine 3-kinase activity Catalysis of the reaction: ATP + a [protein]-N6-D-fructosyl-L-lysine <=> ADP + H+ + a [protein]-N6-(3-O-phospho-D-fructosyl)-L-lysine. got7fsn_ti fructosamine-3-kinase activity GO:0030387 RHEA:59832|MetaCyc:RXN-12005|EC:2.7.1.171 molecular_function owl:Class
GO:0005665 biolink:NamedThing RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. got7fsn_ti RNA polymerase II complex|RNAP II complex|DNA-directed RNA polymerase II, core complex cellular_component owl:Class
GO:0070417 biolink:NamedThing cellular response to cold Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. got7fsn_ti cellular response to cold stress biological_process owl:Class
GO:0009409 biolink:NamedThing response to cold Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. got7fsn_ti freezing tolerance biological_process owl:Class
GO:0035716 biolink:NamedThing chemokine (C-C motif) ligand 12 binding Binding to chemokine (C-C motif) ligand 12. got7fsn_ti CCL12 binding bf 2011-03-03T04:25:01Z molecular_function owl:Class
GO:0019957 biolink:NamedThing C-C chemokine binding Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. got7fsn_ti molecular_function owl:Class
GO:0007503 biolink:NamedThing fat body development The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism. got7fsn_ti biological_process owl:Class
GO:0071471 biolink:NamedThing cellular response to non-ionic osmotic stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment. got7fsn_ti mah 2009-12-18T11:47:59Z biological_process owl:Class
GO:0047047 biolink:NamedThing oxaloglycolate reductase (decarboxylating) activity Catalysis of the reaction: glycerate + CO2 + NAD(P)+ = NAD(P)H + H+ + 2-hydroxy-3-oxosuccinate. got7fsn_ti D-glycerate:NAD(P)+ oxidoreductase (carboxylating) MetaCyc:1.1.1.92-RXN|EC:1.1.1.92 molecular_function owl:Class
GO:0072513 biolink:NamedThing positive regulation of secondary heart field cardioblast proliferation Any process that activates or increases the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract). got7fsn_ti negative regulation of second heart field cardioblast proliferation mah 2010-12-17T10:16:43Z biological_process owl:Class
GO:0003266 biolink:NamedThing regulation of secondary heart field cardioblast proliferation Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract). got7fsn_ti regulation of SHF cardioblast proliferation|regulation of second heart field cardioblast proliferation dph 2009-10-15T02:26:15Z biological_process owl:Class
GO:0043920 biolink:NamedThing aminopropylagmatine ureohydrolase activity Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea. got7fsn_ti EC:3.5.3.24|RHEA:35827 molecular_function owl:Class
GO:0006239 biolink:NamedThing dCMP salvage Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis. got7fsn_ti deoxycytidine monophosphate salvage biological_process owl:Class
GO:0010139 biolink:NamedThing pyrimidine deoxyribonucleotide salvage The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis. got7fsn_ti MetaCyc:PWY0-181 biological_process owl:Class
GO:0044417 biolink:NamedThing translocation of molecules into host The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti translocation of molecules into other organism during symbiotic interaction|transport of molecules into other organism during symbiotic interaction|translocation of molecules into other organism involved in symbiotic interaction|transport of molecules into host GO:0051836 biological_process owl:Class
GO:0051701 biolink:NamedThing biological process involved in interaction with host An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. got7fsn_ti growth of symbiont in host|growth of symbiont in host organelle|growth of symbiont in host cell|growth of symbiont in host vacuole|interaction with host https://github.com/geneontology/go-ontology/issues/20191 GO:0044125|GO:0044121|GO:0044123|GO:0044119|GO:0044112|GO:0044116|GO:0044117 biological_process owl:Class
GO:0004351 biolink:NamedThing glutamate decarboxylase activity Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. got7fsn_ti L-glutamic decarboxylase activity|aspartic alpha-decarboxylase|L-glutamic acid decarboxylase activity|cysteic acid decarboxylase activity|L-glutamate alpha-decarboxylase activity|L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)|gamma-glutamate decarboxylase activity|L-aspartate-alpha-decarboxylase activity|L-glutamate 1-carboxy-lyase activity Reactome:R-HSA-888577|EC:4.1.1.15|RHEA:17785|MetaCyc:GLUTDECARBOX-RXN|Reactome:R-HSA-888572 molecular_function owl:Class
GO:0140457 biolink:NamedThing protein demethylase activity Catalysis of the removal of a methyl group from a protein. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19325 pg 2020-04-23T07:39:14Z molecular_function owl:Class
GO:0014072 biolink:NamedThing response to isoquinoline alkaloid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids. got7fsn_ti biological_process owl:Class
GO:0014070 biolink:NamedThing response to organic cyclic compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. got7fsn_ti response to organic cyclic substance biological_process owl:Class
GO:0034740 biolink:NamedThing TFIIIC-TOP1-SUB1 complex A protein complex that contains TFIIIC, topoisomerase 1, and Sub1/PC4. Characterized in human, the complex is involved in regulating transcription from RNA polymerase III (Pol III) promoters. Topoisomerase 1 and Sub1 enhance the accuracy of transcription termination, and promote reinitiation by Pol III. got7fsn_ti TFIIIC-Topoisomerase 1-PC4 complex cellular_component owl:Class
GO:0090576 biolink:NamedThing RNA polymerase III transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III. got7fsn_ti RNA polymerase III transcription factor complex tb 2014-05-09T14:04:37Z cellular_component owl:Class
GO:0051981 biolink:NamedThing copper chelate transmembrane transporter activity Enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. got7fsn_ti molecular_function owl:Class
GO:0005375 biolink:NamedThing copper ion transmembrane transporter activity Enables the transfer of copper (Cu) ions from one side of a membrane to the other. got7fsn_ti copper uptake transmembrane transporter activity|plasma membrane copper transporter|intracellular copper ion transporter GO:0015088|GO:0005380|GO:0005378|GO:0005379 RHEA:28703|Reactome:R-HSA-437300 molecular_function owl:Class
GO:0061193 biolink:NamedThing taste bud development The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors. got7fsn_ti dph 2010-07-27T10:55:08Z biological_process owl:Class
GO:0060516 biolink:NamedThing primary prostatic bud elongation The increase in size of the prostatic bud as it forms. got7fsn_ti prostate bud elongation|prostate bud elongation involved in prostate morphogenesis biological_process owl:Class
GO:0052200 biolink:NamedThing response to host defenses Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response to host defense molecules|response of symbiont to host defense molecules|maintenance of symbiont tolerance to host defense molecules https://github.com/geneontology/go-ontology/issues/18827|https://github.com/geneontology/go-ontology/issues/18951 Note that this term is used to annotate gene products of the symbiont. GO:0075140|GO:0075145 biological_process owl:Class
GO:0033060 biolink:NamedThing ocellus pigmentation The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates. got7fsn_ti biological_process owl:Class
GO:0043473 biolink:NamedThing pigmentation The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells. got7fsn_ti biological_process owl:Class
GO:1990922 biolink:NamedThing hepatic stellate cell proliferation The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver. got7fsn_ti Ito cell proliferation|hepatic perisinusoidal cell proliferation|perisinusoidal cell proliferation sl 2016-01-13T23:12:57Z biological_process owl:Class
GO:0048144 biolink:NamedThing fibroblast proliferation The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population. got7fsn_ti biological_process owl:Class
GO:0031234 biolink:NamedThing extrinsic component of cytoplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to cytoplasmic side of plasma membrane|extrinsic to internal leaflet of plasma membrane|extrinsic to internal side of plasma membrane Consider also annotating to 'cell cortex ; GO:0005938'. cellular_component owl:Class
GO:0019897 biolink:NamedThing extrinsic component of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to plasma membrane|peripheral plasma membrane protein|juxtamembrane GO:0000157 cellular_component owl:Class
GO:0050546 biolink:NamedThing 4-hydroxyphenylpyruvate decarboxylase activity Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO(2). got7fsn_ti 4-hydroxyphenylpyruvate carboxy-lyase (4-hydroxyphenylacetaldehyde-forming)|4-hydroxyphenylpyruvate carboxy-lyase activity KEGG_REACTION:R03341|RHEA:18697|EC:4.1.1.80|MetaCyc:4.1.1.80-RXN molecular_function owl:Class
GO:0044230 biolink:NamedThing host cell envelope An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present. got7fsn_ti jl 2009-12-03T03:24:03Z cellular_component owl:Class
GO:0033643 biolink:NamedThing host cell part Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class
GO:0018908 biolink:NamedThing organosulfide cycle A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle. got7fsn_ti organosulphide cycle UM-BBD_pathwayID:sulf biological_process owl:Class
GO:0006790 biolink:NamedThing sulfur compound metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. got7fsn_ti sulphur metabolic process|sulfur metabolism|sulphur metabolism Wikipedia:Sulfur_metabolism biological_process owl:Class
GO:0018034 biolink:NamedThing C-terminal peptidyl-alanine amidation The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0081 biological_process owl:Class
GO:0018033 biolink:NamedThing protein C-terminal amidation The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein. got7fsn_ti biological_process owl:Class
GO:0006066 biolink:NamedThing alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. got7fsn_ti alcohol metabolism biological_process owl:Class
GO:0047336 biolink:NamedThing 5-methyldeoxycytidine-5'-phosphate kinase activity Catalysis of the reaction: 2'-deoxy-5-methyl-5'-cytidylate + ATP = 5-methyldeoxycytidine diphosphate + ADP + H(+). got7fsn_ti ATP:5-methyldeoxycytidine-5'-phosphate phosphotransferase activity EC:2.7.4.19|KEGG_REACTION:R04235|RHEA:11396|MetaCyc:2.7.4.19-RXN molecular_function owl:Class
GO:0035554 biolink:NamedThing termination of Roundabout signal transduction The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated. got7fsn_ti bf 2010-05-14T11:08:12Z biological_process owl:Class
GO:0102770 biolink:NamedThing inositol phosphorylceramide synthase activity Catalysis of the reaction: an L-1-phosphatidyl-inositol + a dihydroceramide = an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol. got7fsn_ti MetaCyc:RXN-7795 molecular_function owl:Class
GO:0008677 biolink:NamedThing 2-dehydropantoate 2-reductase activity Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH. got7fsn_ti (R)-pantoate:NADP+ 2-oxidoreductase activity|2-ketopantoate reductase activity|2-ketopantoic acid reductase activity|2-oxopantoate reductase activity|ketopantoate reductase activity|ketopantoic acid reductase activity|KPA reductase activity MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN|EC:1.1.1.169|RHEA:16233|KEGG_REACTION:R02472 molecular_function owl:Class
GO:0006023 biolink:NamedThing aminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages. got7fsn_ti aminoglycan biosynthesis|aminoglycan anabolism|aminoglycan formation|aminoglycan synthesis biological_process owl:Class
GO:0043813 biolink:NamedThing phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. got7fsn_ti phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity Reactome:R-HSA-1676174|Reactome:R-HSA-1676005|Reactome:R-HSA-1675836|Reactome:R-HSA-1676020 molecular_function owl:Class
GO:0048319 biolink:NamedThing axial mesoderm morphogenesis The process in which the anatomical structures of the axial mesoderm are generated and organized. got7fsn_ti biological_process owl:Class
GO:0048332 biolink:NamedThing mesoderm morphogenesis The process in which the anatomical structures of the mesoderm are generated and organized. got7fsn_ti biological_process owl:Class
GO:0052204 biolink:NamedThing negative regulation of molecular function in other organism involved in symbiotic interaction Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of proteins in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti negative regulation of protein function in other organism during symbiotic interaction|down regulation of protein function in other organism during symbiotic interaction|inhibition of protein function in other organism during symbiotic interaction|down-regulation of protein function in other organism during symbiotic interaction|inhibition of protein function in other organism|downregulation of protein function in other organism during symbiotic interaction biological_process owl:Class
GO:0044362 biolink:NamedThing negative regulation of molecular function in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism. got7fsn_ti jl 2011-10-27T02:12:49Z biological_process owl:Class
GO:0016207 biolink:NamedThing 4-coumarate-CoA ligase activity Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA. got7fsn_ti hydroxycinnamoyl CoA synthetase activity|4-coumarate:CoA ligase activity|4-coumaroyl-CoA synthetase activity|feruloyl coenzyme A synthetase activity|4-coumarate:CoA ligase (AMP-forming)|p-hydroxycinnamoyl coenzyme A synthetase activity|sinapoyl coenzyme A synthetase activity|feruloyl CoA ligase activity|p-coumaryl-CoA ligase activity|p-coumaroyl CoA ligase activity|p-coumaryl-CoA synthetase activity|4-coumarate:coenzyme A ligase activity|4-coumaroyl-CoA synthase activity|hydroxycinnamate:CoA ligase activity|p-coumaryl coenzyme A synthetase activity|caffeolyl coenzyme A synthetase activity|4CL|4-coumaryl-CoA synthetase activity|p-hydroxycinnamic acid:CoA ligase activity|4-coumarate-CoA synthetase activity KEGG_REACTION:R01616|EC:6.2.1.12|MetaCyc:4-COUMARATE--COA-LIGASE-RXN|RHEA:19641 molecular_function owl:Class
GO:0019627 biolink:NamedThing urea metabolic process The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2. got7fsn_ti urea metabolism biological_process owl:Class
GO:0048108 biolink:NamedThing peptide cross-linking via 4-amino-3-isothiazolidinone The formation of 4-amino-3-isothiazolinone cross-links by the formation of a sulfenylamide bond between cysteine or cysteine sulfenic acid, and the alpha-amido of the following residue. got7fsn_ti Note that this is a generic parent because the identity of the second amino acid is not critical for formation of the cross-link. biological_process owl:Class
GO:0048630 biolink:NamedThing skeletal muscle tissue growth The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size. got7fsn_ti biological_process owl:Class
GO:0097182 biolink:NamedThing protein C inhibitor-coagulation factor Xa complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa. got7fsn_ti plasma serine protease inhibitor-coagulation factor Xa complex|PCI-coagulation factor Xa complex|serpin A5-coagulation factor Xa complex|SERPINA5-coagulation factor Xa complex pr 2011-10-16T09:01:29Z cellular_component owl:Class
GO:0048834 biolink:NamedThing specification of petal number Any process that modulates the number of petals formed in a flower. got7fsn_ti biological_process owl:Class
GO:0048833 biolink:NamedThing specification of floral organ number Any process that modulates the number of floral organs formed in a floral whorl. got7fsn_ti biological_process owl:Class
GO:0033878 biolink:NamedThing hormone-sensitive lipase activity Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate. got7fsn_ti HSL|diacylglycerol acylhydrolase activity MetaCyc:STEROL-ESTERASE-RXN|MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN|EC:3.1.1.79 molecular_function owl:Class
GO:0007260 biolink:NamedThing tyrosine phosphorylation of STAT protein The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. got7fsn_ti tyrosine phosphorylation of Stat6 protein|tyrosine phosphorylation of Stat1 protein|tyrosine phosphorylation of Stat4 protein|tyrosine phosphorylation of Stat3 protein|tyrosine phosphorylation of Stat5 protein|tyrosine phosphorylation of Stat7 protein|tyrosine phosphorylation of Stat2 protein GO:0042505|GO:0042504|GO:0042508|GO:0042507|GO:0042503|GO:0042502|GO:0042506 biological_process owl:Class
GO:0018108 biolink:NamedThing peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. got7fsn_ti RESID:AA0039 biological_process owl:Class
GO:0033926 biolink:NamedThing glycopeptide alpha-N-acetylgalactosaminidase activity Catalysis of the reaction: D-galactosyl-3-(N-acetyl-alpha-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-alpha-D-galactosamine + L-serine in mucin-type glycoproteins. got7fsn_ti endo-alpha-acetylgalactosaminidase activity|endo-alpha-N-acetylgalactosaminidase activity|D-galactosyl-N-acetyl-alpha-D-galactosamine D-galactosyl-N-acetyl-galactosaminohydrolase activity EC:3.2.1.97|MetaCyc:3.2.1.97-RXN molecular_function owl:Class
GO:0102660 biolink:NamedThing caffeoyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity Catalysis of the reaction: caffeoylshikimate + coenzyme A <=> caffeoyl-CoA + shikimate. got7fsn_ti MetaCyc:RXN-2621 molecular_function owl:Class
GO:0010492 biolink:NamedThing maintenance of shoot apical meristem identity The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. got7fsn_ti biological_process owl:Class
GO:0010074 biolink:NamedThing maintenance of meristem identity The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. got7fsn_ti meristem cell maintenance|maintenance of meristem cell identity GO:0032503 biological_process owl:Class
GO:0051987 biolink:NamedThing positive regulation of attachment of spindle microtubules to kinetochore Any process that activates or increases the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. got7fsn_ti activation of attachment of spindle microtubules to kinetochore|up-regulation of attachment of spindle microtubules to kinetochore|upregulation of attachment of spindle microtubules to kinetochore|stimulation of attachment of spindle microtubules to kinetochore|up regulation of attachment of spindle microtubules to kinetochore biological_process owl:Class
GO:0051984 biolink:NamedThing positive regulation of chromosome segregation Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. got7fsn_ti up regulation of chromosome segregation|upregulation of chromosome segregation|up-regulation of chromosome segregation|stimulation of chromosome segregation|activation of chromosome segregation biological_process owl:Class
GO:0044808 biolink:NamedThing oncostatin M production The appearance of oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Oncostatin M production|OSM production jl 2013-09-11T12:18:00Z biological_process owl:Class
GO:0010287 biolink:NamedThing plastoglobule A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids. got7fsn_ti plastoglobuli|PG GO:0010502 cellular_component owl:Class
GO:0008689 biolink:NamedThing 3-demethylubiquinone-9 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9. got7fsn_ti 5-demethylubiquinone-9 methyltransferase activity|OMHMB-methyltransferase activity|S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity|S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity MetaCyc:DHHB-METHYLTRANSFER-RXN|RHEA:17049|EC:2.1.1.64 molecular_function owl:Class
GO:0061542 biolink:NamedThing 3-demethylubiquinol-n 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-n = S-adenosyl-L-homocysteine + ubiquinol-n. got7fsn_ti 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase|5-demethylubiquinone-10 methyltransferase|S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase|5-demethylubiquinone-9 methyltransferase|OMHMB-methyltransferase dph 2013-06-25T08:01:46Z molecular_function owl:Class
GO:0005664 biolink:NamedThing nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. got7fsn_ti eukaryotic ORC|nuclear ORC cellular_component owl:Class
GO:0031981 biolink:NamedThing nuclear lumen The volume enclosed by the nuclear inner membrane. got7fsn_ti cellular_component owl:Class
GO:0070013 biolink:NamedThing intracellular organelle lumen An organelle lumen that is part of an intracellular organelle. got7fsn_ti cellular_component owl:Class
GO:0102073 biolink:NamedThing OPC8-trans-2-enoyl-CoA hydratase activity Catalysis of the reaction: OPC8-3-hydroxyacyl-CoA <=> OPC8-trans-2-enoyl-CoA + H2O. got7fsn_ti MetaCyc:RXN-10697 molecular_function owl:Class
GO:0032245 biolink:NamedThing regulation of purine nucleoside transport Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0032242 biolink:NamedThing regulation of nucleoside transport Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0050234 biolink:NamedThing pyrazolylalanine synthase activity Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H(2)O. got7fsn_ti L-serine hydro-lyase [adding pyrazole; 3-(pyrazol-1-yl)-L-alanine-forming]|beta-pyrazolylalaninase activity|L-serine hydro-lyase (adding pyrazole) RHEA:24512|EC:4.2.1.50|KEGG_REACTION:R02378|MetaCyc:PYRAZOLYLALANINE-SYNTHASE-RXN molecular_function owl:Class
GO:0039651 biolink:NamedThing induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process Any process in which a virus increases the frequency, rate or extent of host cysteine-type endopeptidase activity (also called caspase activity) which contributes to the apoptotic process. got7fsn_ti activation of host caspases by virus|induction by virus of host caspase activity bf 2012-10-09T15:44:29Z biological_process owl:Class
GO:0019051 biolink:NamedThing induction by virus of host apoptotic process The set of viral processes that induce an apoptotic process in infected host cells, facilitating release and spread of progeny virions. got7fsn_ti activation of apoptosis in host by virus|induction by virus of host apoptotic programmed cell death|activation by virus of host apoptosis|induction by virus of host apoptosis|activation by virus of host apoptotic programmed cell death|induction of apoptosis in host by virus biological_process owl:Class
GO:0098723 biolink:NamedThing skeletal muscle myofibril A myofibril of a skeletal muscle fiber. got7fsn_ti cellular_component owl:Class
GO:0030016 biolink:NamedThing myofibril The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. got7fsn_ti Wikipedia:Myofibril cellular_component owl:Class
GO:0004978 biolink:NamedThing corticotropin receptor activity Combining with corticotropin to initiate a change in cell activity. got7fsn_ti adrenocorticotropin receptor activity|ACTH receptor activity|adrenocorticotropic hormone receptor activity molecular_function owl:Class
GO:0004977 biolink:NamedThing melanocortin receptor activity Combining with melanocortin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:1904951 biolink:NamedThing positive regulation of establishment of protein localization Any process that activates or increases the frequency, rate or extent of establishment of protein localization. got7fsn_ti up regulation of protein recruitment|positive regulation of establishment of protein localisation|upregulation of establishment of protein localization|upregulation of protein positioning|up regulation of establishment of protein localization|positive regulation of protein recruitment|up-regulation of establishment of protein localization|activation of protein recruitment|up regulation of establishment of protein localisation|activation of protein positioning|upregulation of protein recruitment|up-regulation of protein positioning|upregulation of establishment of protein localisation|activation of establishment of protein localization|activation of establishment of protein localisation|up regulation of protein positioning|up-regulation of protein recruitment|up-regulation of establishment of protein localisation|positive regulation of protein positioning mec 2016-02-05T09:59:32Z biological_process owl:Class
GO:0060158 biolink:NamedThing phospholipase C-activating dopamine receptor signaling pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). got7fsn_ti activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signalling pathway|dopamine receptor, phospholipase C activating pathway biological_process owl:Class
GO:0007200 biolink:NamedThing phospholipase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). got7fsn_ti phospholipase C-activating dopamine receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|PLC-activating GPCR signaling pathway|G-protein coupled receptor signaling pathway coupled to IP3 second messenger|G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)|G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|G protein signaling, coupled to IP3 second messenger (phospholipase C activating)|G protein signalling, coupled to IP3 second messenger (phospholipase C activating) This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity. biological_process owl:Class
GO:0042389 biolink:NamedThing omega-3 fatty acid desaturase activity Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain. got7fsn_ti molecular_function owl:Class
GO:0052430 biolink:NamedThing modulation by host of symbiont RNA levels The alteration by an organism of the levels of RNA in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0051851 biolink:NamedThing modulation by host of symbiont process The process in which an organism effects a change in the structure or processes of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti modification by host of symbiont morphology or physiology biological_process owl:Class
GO:0052775 biolink:NamedThing endo-1,3-alpha-L-rhamnosidase activity Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain. got7fsn_ti endorhamnosidase activity|endo-(1,3)-alpha-L-rhamnosidase activity|endo-(1->3)-alpha-L-rhamnosidase activity ai 2011-10-05T03:30:33Z molecular_function owl:Class
GO:0010944 biolink:NamedThing negative regulation of transcription by competitive promoter binding Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site. got7fsn_ti biological_process owl:Class
GO:0090446 biolink:NamedThing negative regulation of nematode larval development, heterochronic Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached. got7fsn_ti tb 2012-08-24T13:24:43Z biological_process owl:Class
GO:0090444 biolink:NamedThing regulation of nematode larval development, heterochronic Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached. got7fsn_ti tb 2012-08-24T13:24:43Z biological_process owl:Class
GO:0090650 biolink:NamedThing cellular response to oxygen-glucose deprivation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose. got7fsn_ti cellular response to OGD tb 2015-07-01T10:27:29Z biological_process owl:Class
GO:0036294 biolink:NamedThing cellular response to decreased oxygen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen. got7fsn_ti cellular response to lowered oxygen levels This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'cellular response to hypoxia ; GO:0071456'. bf 2012-07-20T01:08:40Z biological_process owl:Class
GO:0102815 biolink:NamedThing caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-caffeoylglucoside + coenzyme A. got7fsn_ti MetaCyc:RXN-8233|EC:2.3.1.153 molecular_function owl:Class
GO:0005464 biolink:NamedThing UDP-xylose transmembrane transporter activity Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. got7fsn_ti Reactome:R-HSA-742373 molecular_function owl:Class
GO:0015165 biolink:NamedThing pyrimidine nucleotide-sugar transmembrane transporter activity Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. got7fsn_ti molecular_function owl:Class
GO:0003012 biolink:NamedThing muscle system process A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. got7fsn_ti muscle physiological process biological_process owl:Class
GO:0062167 biolink:NamedThing complement component C1q complex A protein-containing complex composed of six subunits of each of the three homologous polypeptide chains C1QA, C1QB, and C1QB. It is a subunit of the complement C1 complex. In addition to complement activation, C1q appears to have roles in homeostasis and cellular development, superoxide (O2-) production by neutrophils, blood coagulation and neurological synapse pruning. got7fsn_ti C1q|Complement 1q dph 2019-11-12T13:21:57Z cellular_component owl:Class
GO:0006720 biolink:NamedThing isoprenoid metabolic process The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. got7fsn_ti polyterpene metabolism|polyterpene metabolic process|polyisoprenoid metabolic process|polyisoprenoid metabolism|isoprenoid metabolism GO:0016096 biological_process owl:Class
GO:0014848 biolink:NamedThing urinary tract smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra. got7fsn_ti biological_process owl:Class
GO:0006939 biolink:NamedThing smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. got7fsn_ti visceral muscle contraction biological_process owl:Class
GO:0019843 biolink:NamedThing rRNA binding Binding to a ribosomal RNA. got7fsn_ti base pairing with rRNA GO:0000944 molecular_function owl:Class
GO:0003723 biolink:NamedThing RNA binding Binding to an RNA molecule or a portion thereof. got7fsn_ti poly(A) RNA binding|poly(A)-RNA binding|poly-A RNA binding|base pairing with RNA GO:0000498|GO:0044822 Reactome:R-HSA-203922 molecular_function owl:Class
GO:0008999 biolink:NamedThing ribosomal-protein-alanine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine. got7fsn_ti acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity|ribosomal protein S18 acetyltransferase activity EC:2.3.1.267|MetaCyc:2.3.1.128-RXN molecular_function owl:Class
GO:0021798 biolink:NamedThing forebrain dorsal/ventral pattern formation The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain. got7fsn_ti forebrain dorsal-ventral pattern formation|forebrain dorsoventral pattern formation biological_process owl:Class
GO:0009953 biolink:NamedThing dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. got7fsn_ti dorsoventral pattern formation|dorsal/ventral pattern specification|dorsal-ventral pattern formation biological_process owl:Class
GO:0030566 biolink:NamedThing snRNA modification guide activity Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0017069 biolink:NamedThing snRNA binding Binding to a small nuclear RNA (snRNA). got7fsn_ti small nuclear RNA binding|base pairing with snRNA GO:0000945 molecular_function owl:Class
GO:0075502 biolink:NamedThing endosome membrane permeabilization involved in viral entry into host cell Induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus through the endosomal pathway, and results in delivery of the virus contents into the host cell cytoplasm. got7fsn_ti viral entry into host cell via caveolae-mediated endocytosis followed by endosome membrane|viral entry into host cell via clathrin-mediated endocytosis followed by endosome membrane permeabilization jl 2010-06-02T02:40:25Z GO:0075518 biological_process owl:Class
GO:0039665 biolink:NamedThing permeabilization of host organelle membrane involved in viral entry into host cell Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm. got7fsn_ti viral penetration via permeabilization of host organellar membrane|viral penetration via host endosomal membrane disruption by virus|viral membrane-penetration protein|viral entry into host cell via permeabilization of host organelle membrane|viral penetration via perforation of host organellar membrane by virus bf 2013-08-29T11:57:21Z VZ:985 biological_process owl:Class
GO:0042766 biolink:NamedThing nucleosome mobilization The movement of nucleosomes along a DNA fragment. got7fsn_ti nucleosome sliding biological_process owl:Class
GO:0034728 biolink:NamedThing nucleosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes. got7fsn_ti nucleosome organisation biological_process owl:Class
GO:0047508 biolink:NamedThing (R)-2-methylmalate dehydratase activity Catalysis of the reaction: (R)-citramalate = 2-methylmaleate + H(2)O. got7fsn_ti (R)-2-methylmalate hydro-lyase activity|citraconate hydratase activity|citraconase activity|citramalate hydro-lyase activity|(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)|(-)-citramalate hydro-lyase activity MetaCyc:R-2-METHYLMALATE-DEHYDRATASE-RXN|EC:4.2.1.35|RHEA:22332|KEGG_REACTION:R03896 molecular_function owl:Class
GO:0102387 biolink:NamedThing 2-phenylethanol acetyltransferase activity Catalysis of the reaction: 2-phenylethanol + acetyl-CoA = phenethyl acetate + coenzyme A. got7fsn_ti EC:2.3.1.224|MetaCyc:RXN-13542 molecular_function owl:Class
GO:0036163 biolink:NamedThing 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2. got7fsn_ti bf 2012-03-26T01:49:54Z RHEA:44768|KEGG_REACTION:R06866 molecular_function owl:Class
GO:0018608 biolink:NamedThing 1-indanone dioxygenase activity Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone. got7fsn_ti EC:1.14.12.-|UM-BBD_reactionID:r0416 molecular_function owl:Class
GO:0061762 biolink:NamedThing CAMKK-AMPK signaling cascade A series of molecular signals in which calmodulin-dependent protein kinase activity enabled by a CAMKK directly activates an AMPK. The cascade begins with calmodulin binding calcium which in turn binds CAMKK enabling its calmodulin-dependent protein kinase activity. The cascade ends with AMP-activated protein kinase activity. got7fsn_ti stress-activated AMP-activated protein kinase signaling cascade dph 2016-04-14T12:59:31Z biological_process owl:Class
GO:0019722 biolink:NamedThing calcium-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. got7fsn_ti calcium ion signaling|calcium signaling|calcium-mediated signalling|calcium signalling Wikipedia:Calcium_signaling biological_process owl:Class
GO:0052039 biolink:NamedThing disruption by symbiont of host cytoskeleton The process in which an organism effects a change that impairs the structure or function of the host cytoskeleton. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modification by symbiont of host cytoskeleton|rounding by symbiont of host cells GO:0044054 biological_process owl:Class
GO:0002473 biolink:NamedThing non-professional antigen presenting cell antigen processing and presentation The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils. got7fsn_ti biological_process owl:Class
GO:0019177 biolink:NamedThing dihydroneopterin triphosphate pyrophosphohydrolase activity Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. got7fsn_ti RHEA:25302|MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN molecular_function owl:Class
GO:0047297 biolink:NamedThing asparagine-oxo-acid transaminase activity Catalysis of the reaction: a 2-oxo acid + L-asparagine = an amino acid + 2-oxosuccinamate. got7fsn_ti asparagine-oxo-acid aminotransferase activity|L-asparagine:2-oxo-acid aminotransferase activity|asparagine-keto acid aminotransferase activity|asparagine--oxo-acid aminotransferase activity EC:2.6.1.14|RHEA:19813|MetaCyc:2.6.1.14-RXN molecular_function owl:Class
GO:0102424 biolink:NamedThing sesaminol-2-O-gentiobioside 1,6-glucosyltransferase activity Catalysis of the reaction: (+)-sesaminol 2-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-gentiotrioside + UDP + H+. got7fsn_ti MetaCyc:RXN-13821 molecular_function owl:Class
GO:0042986 biolink:NamedThing positive regulation of amyloid precursor protein biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. got7fsn_ti upregulation of amyloid precursor protein biosynthetic process|stimulation of amyloid precursor protein biosynthetic process|activation of amyloid precursor protein biosynthetic process|up-regulation of amyloid precursor protein biosynthetic process|positive regulation of APP biosynthesis|positive regulation of amyloid precursor protein biosynthesis|positive regulation of amyloid precursor protein formation|positive regulation of amyloid precursor protein anabolism|up regulation of amyloid precursor protein biosynthetic process|positive regulation of APP biosynthetic process|positive regulation of amyloid precursor protein synthesis biological_process owl:Class
GO:0010560 biolink:NamedThing positive regulation of glycoprotein biosynthetic process Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. got7fsn_ti biological_process owl:Class
GO:0044666 biolink:NamedThing MLL3/4 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species. got7fsn_ti Trr/COMPASS-like complex jl 2012-08-07T14:46:40Z cellular_component owl:Class
GO:0035097 biolink:NamedThing histone methyltransferase complex A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins. got7fsn_ti cellular_component owl:Class
GO:0044569 biolink:NamedThing [Ni-Fe] hydrogenase complex A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer. got7fsn_ti Ni-Fe hydrogenase complex|nickel-iron hydrogenase complex jl 2012-04-18T01:26:35Z cellular_component owl:Class
GO:1902494 biolink:NamedThing catalytic complex A protein complex which is capable of catalytic activity. got7fsn_ti enzyme complex bhm 2013-11-13T16:18:47Z cellular_component owl:Class
GO:0051823 biolink:NamedThing regulation of synapse structural plasticity Any process that modulates the frequency, rate or extent of synapse structural plasticity. Synapse structural plasticity is a type of cytoskeletal remodeling; this remodeling is induced by stimuli that can lead to long term potentiation and it can be activity-dependent or -independent. Examples of cytoskeletal changes include the formation of new spines and increase in spine size; this can be accompanied by the insertion of greater numbers of glutamate (or other neurotransmitter) receptors into the post-synaptic membrane. got7fsn_ti regulation of synaptic structural plasticity biological_process owl:Class
GO:0050807 biolink:NamedThing regulation of synapse organization Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). got7fsn_ti regulation of synapse organisation|regulation of synapse organization and biogenesis|regulation of synapse structure biological_process owl:Class
GO:0018259 biolink:NamedThing RNA-protein covalent cross-linking via peptidyl-serine The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine. got7fsn_ti RESID:AA0213 biological_process owl:Class
GO:0018144 biolink:NamedThing RNA-protein covalent cross-linking The formation of a covalent cross-link between RNA and a protein. got7fsn_ti biological_process owl:Class
GO:0003091 biolink:NamedThing renal water homeostasis Renal process involved in the maintenance of an internal steady state of water in the body. got7fsn_ti water homeostasis by the renal system biological_process owl:Class
GO:0004503 biolink:NamedThing tyrosinase activity Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. got7fsn_ti pyrocatechol oxidase|chlorogenic oxidase activity|phenolase activity|catecholase|o-diphenol oxidase activity|monophenolase activity|monophenol oxidase activity|L-tyrosine monooxygenase activity|dopa oxidase|tyrosine-dopa oxidase activity|monophenol oxygenase|N-acetyl-6-hydroxytryptophan oxidase activity|prophenoloxidase activity|monophenol monooxygenase activity|o-diphenol:O2 oxidoreductase activity|monophenol monooxidase activity|chlorogenic acid oxidase activity|o-diphenol oxidoreductase|prophenol oxidase activity|phenol oxidase activity|cresolase activity https://github.com/geneontology/go-ontology/issues/21024#issuecomment-909025243 In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children. EC:1.14.18.1|MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN|RHEA:18117 molecular_function owl:Class
GO:0016716 biolink:NamedThing oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. got7fsn_ti EC:1.14.18.- molecular_function owl:Class
GO:1904071 biolink:NamedThing presynaptic active zone assembly The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. got7fsn_ti pre-synaptic active zone component formation|pre-synaptic active zone assembly|pre-synaptic active zone component assembly|pre-synaptic active zone formation|presynaptic active zone formation pr 2015-03-20T10:36:27Z biological_process owl:Class
GO:0085017 biolink:NamedThing entry into host cell by a symbiont-containing vacuole The invasion by a symbiont of a cell of a host organism, forming a vacuole in which the symbiont resides. The vacuole membrane is formed from lipids and proteins derived from both host and symbiont. Begins when the symbiont attaches on to the host cell membrane which invaginates and deepens as the symbiont enters, and ends when the host cell membrane closes behind the newly-formed vacuole. got7fsn_ti symbiont entry into host cell forming a symbiont-containing vacuole|symbiont entry into host cell forming a pathogen-containing vacuole|symbiont entry into host cell forming a parasitophorous vacuole jl 2010-05-20T02:55:34Z GO:0052370 biological_process owl:Class
GO:0044409 biolink:NamedThing entry into host Entry of a symbiont into the body, tissues, or cells of a host organism as part of the symbiont life cycle. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti invasion of host|other organism cell invasion|entry into host via a specialized structure during symbiotic interaction|invasion of other organism|entry into host cell via penetration peg|penetration into host|entry into host via enzymatic degradation of host anatomical structure|invasion into other organism|entry into host through host barriers|penetration into host via a specialized structure during symbiotic interaction|invasion into host|host penetration|other organism invasion|entry into cell of other organism during symbiotic interaction|entry into other organism involved in symbiotic interaction|penetration into host via a specialized structure|host cell invasion|entry into cell of other organism involved in symbiotic interaction|invasive growth|entry into other organism during symbiotic interaction|host invasion|entry into host via enzymatic degradation of host cuticle|entry into host cell https://github.com/geneontology/go-ontology/issues/18563 GO:0051830|GO:0085028|GO:0051806|GO:0044411|GO:0085027|GO:0075052|GO:0051828|GO:0030260 biological_process owl:Class
GO:0052126 biolink:NamedThing movement in host environment The directed movement of an organism or motile cell on, within or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti movement in response to host biological_process owl:Class
GO:0008928 biolink:NamedThing mannose-1-phosphate guanylyltransferase (GDP) activity Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate. got7fsn_ti GDP-mannose phosphorylase activity|mannose 1-phosphate guanylyltransferase activity|GDP-mannose 1-phosphate guanylyltransferase activity|GDP-mannose pyrophosphorylase activity|GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity|GDP:mannose-1-phosphate guanylyltransferase activity|GDP mannose phosphorylase activity|guanosine diphosphomannose phosphorylase activity|mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity|guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity|GDP:D-mannose-1-phosphate guanylyltransferase activity EC:2.7.7.22|KEGG_REACTION:R00883|MetaCyc:MANNPGUANYLTRANGDP-RXN|RHEA:12905 molecular_function owl:Class
GO:0008905 biolink:NamedThing mannose-phosphate guanylyltransferase activity Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule. got7fsn_ti molecular_function owl:Class
GO:1900595 biolink:NamedThing (+)-kotanin catabolic process The chemical reactions and pathways resulting in the breakdown of (+)-kotanin. got7fsn_ti (+)-kotanin degradation|(+)-kotanin breakdown|(+)-kotanin catabolism di 2012-05-15T06:54:40Z biological_process owl:Class
GO:0009252 biolink:NamedThing peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. got7fsn_ti peptidoglycan synthesis|murein biosynthesis|peptidoglycan biosynthesis|murein biosynthetic process|peptidoglycan anabolism|peptidoglycan formation GO:0009285 biological_process owl:Class
GO:0044038 biolink:NamedThing cell wall macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall. got7fsn_ti cell wall macromolecule anabolism|cell wall macromolecule biosynthesis|cell wall macromolecule synthesis|cell wall macromolecule biosynthetic process at cellular level|cellular cell wall macromolecule biosynthetic process biological_process owl:Class
GO:0070087 biolink:NamedThing chromo shadow domain binding Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. got7fsn_ti chromoshadow domain binding molecular_function owl:Class
GO:0072135 biolink:NamedThing kidney mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population in the kidney. got7fsn_ti mah 2010-02-22T02:33:10Z biological_process owl:Class
GO:0010463 biolink:NamedThing mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. got7fsn_ti biological_process owl:Class
GO:0051954 biolink:NamedThing positive regulation of amine transport Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti activation of amine transport|upregulation of amine transport|up-regulation of amine transport|stimulation of amine transport|up regulation of amine transport biological_process owl:Class
GO:0042494 biolink:NamedThing detection of bacterial lipoprotein The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs). got7fsn_ti detection of Lpp|perception of BLP|detection of BLP|perception of bacterial lipoprotein|perception of Lpp biological_process owl:Class
GO:0032493 biolink:NamedThing response to bacterial lipoprotein Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus. got7fsn_ti biological_process owl:Class
GO:0002238 biolink:NamedThing response to molecule of fungal origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide. got7fsn_ti response to fungus associated molecule biological_process owl:Class
GO:0000077 biolink:NamedThing DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint. got7fsn_ti DNA damage checkpoint|signal transduction involved in DNA damage checkpoint|DNA damage response, signal transduction resulting in cell cycle arrest mah 2010-12-08T04:18:11Z GO:0072422 Wikipedia:DNA_damage_checkpoint|Wikipedia:Postreplication_checkpoint biological_process owl:Class
GO:0042770 biolink:NamedThing signal transduction in response to DNA damage A cascade of processes induced by the detection of DNA damage within a cell. got7fsn_ti response to DNA damage stimulus by intracellular signaling cascade|DNA damage response, signal transduction biological_process owl:Class
GO:0051600 biolink:NamedThing regulation of endocytosis by exocyst localization Any process in which an exocyst is transported to, or maintained in, a specific location that results in the modulation of endocytosis. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. got7fsn_ti regulation of site selection of endocytosis|regulation of endocytosis by exocyst localisation|relocation of endocytosis|spatial regulation of endocytosis biological_process owl:Class
GO:0030100 biolink:NamedThing regulation of endocytosis Any process that modulates the frequency, rate or extent of endocytosis. got7fsn_ti biological_process owl:Class
GO:0000812 biolink:NamedThing Swr1 complex A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits. got7fsn_ti SWR-C cellular_component owl:Class
GO:0000118 biolink:NamedThing histone deacetylase complex A protein complex that possesses histone deacetylase activity. got7fsn_ti HDAC complex Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. cellular_component owl:Class
GO:0004879 biolink:NamedThing nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus. got7fsn_ti ligand-dependent nuclear receptor activity|nuclear receptor activity|9-cis retinoic acid receptor activity|vitamin D receptor activity|RXR|retinoic acid receptor activity|calcitriol receptor activity|ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity|1,25-(OH)2D3 receptor activity|vitamin D3 receptor activity|vitamin A receptor activity|ligand-dependent transcription factor activity|glucocorticoid receptor activity|juvenile hormone receptor activity|ecdysteroid hormone receptor activity|estrogen nuclear receptor activity|thyroid hormone receptor activity|RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding|nuclear hormone receptor|RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding|retinoid-X receptor activity|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|androgen receptor activity https://github.com/geneontology/go-ontology/issues/20253|https://github.com/geneontology/go-ontology/issues/19518 Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity. GO:0004886|GO:0008434|GO:0004884|GO:0003708|GO:0004880|GO:0038052|GO:0038051|GO:0004887|GO:0038050|GO:0004882 molecular_function owl:Class
GO:0098531 biolink:NamedThing ligand-activated transcription factor activity A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. got7fsn_ti transcription factor activity, direct ligand regulated sequence-specific DNA binding|direct ligand regulated sequence-specific DNA binding transcription factor activity For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. dos 2013-10-17T15:51:30Z molecular_function owl:Class
GO:1903036 biolink:NamedThing positive regulation of response to wounding Any process that activates or increases the frequency, rate or extent of response to wounding. got7fsn_ti up-regulation of response to wounding|activation of physiological response to wounding|up regulation of response to wounding|up-regulation of physiological response to wounding|positive regulation of physiological response to wounding|activation of response to wounding|upregulation of physiological response to wounding|upregulation of response to wounding|up regulation of physiological response to wounding kmv 2014-05-18T01:28:58Z biological_process owl:Class
GO:1903034 biolink:NamedThing regulation of response to wounding Any process that modulates the frequency, rate or extent of response to wounding. got7fsn_ti regulation of physiological response to wounding kmv 2014-05-18T01:28:46Z biological_process owl:Class
GO:0051964 biolink:NamedThing negative regulation of synapse assembly Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. got7fsn_ti down regulation of synapse assembly|inhibition of synapse assembly|negative regulation of synapse biogenesis|negative regulation of synaptogenesis|down-regulation of synapse assembly|downregulation of synapse assembly biological_process owl:Class
GO:0051961 biolink:NamedThing negative regulation of nervous system development Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. got7fsn_ti down regulation of nervous system development|downregulation of nervous system development|down-regulation of nervous system development|inhibition of nervous system development biological_process owl:Class
GO:0033106 biolink:NamedThing cis-Golgi network membrane The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network. got7fsn_ti Golgi cis face membrane|cis Golgi network membrane cellular_component owl:Class
GO:0140375 biolink:NamedThing immune receptor activity Receiving a signal and transmitting it in a cell to initiate an immune response. got7fsn_ti pg 2019-10-18T14:11:15Z molecular_function owl:Class
GO:0016520 biolink:NamedThing growth hormone-releasing hormone receptor activity Combining with growth hormone-releasing hormone to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0030187 biolink:NamedThing melatonin biosynthetic process The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine). got7fsn_ti melatonin anabolism|melatonin formation|melatonin synthesis|melatonin biosynthesis biological_process owl:Class
GO:0042435 biolink:NamedThing indole-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. got7fsn_ti indole-containing compound formation|indole derivative biosynthetic process|indole-containing compound anabolism|indole-containing compound synthesis|indole-containing compound biosynthesis|indole derivative biosynthesis biological_process owl:Class
GO:0031827 biolink:NamedThing type 2B serotonin receptor binding Binding to a type 2B serotonin receptor. got7fsn_ti 5-hydroxytryptamine 2B receptor binding|type 2B serotonin receptor ligand molecular_function owl:Class
GO:0031821 biolink:NamedThing G protein-coupled serotonin receptor binding Binding to a metabotropic serotonin receptor. got7fsn_ti metabotropic 5-hydroxytryptamine receptor binding|metabotropic serotonin receptor ligand|metabotropic serotonin receptor binding|G-protein coupled serotonin receptor binding molecular_function owl:Class
GO:0043697 biolink:NamedThing cell dedifferentiation The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. got7fsn_ti Note that this term should be used to annotate gene products involved in dedifferentiation that occurs as part of a normal process, such as regeneration. It should not be used for dedifferentiation that occurs in an abnormal or disease state such as cancer. biological_process owl:Class
GO:0043696 biolink:NamedThing dedifferentiation The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors. got7fsn_ti Wikipedia:Cellular_differentiation#Dedifferentiation biological_process owl:Class
GO:0043226 biolink:NamedThing organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. got7fsn_ti Wikipedia:Organelle|NIF_Subcellular:sao1539965131 cellular_component owl:Class
GO:0098629 biolink:NamedThing trans-Golgi network membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane. got7fsn_ti biological_process owl:Class
GO:0005340 biolink:NamedThing nucleotide-sulfate transmembrane transporter activity Enables the transfer of nucleotide-sulfate from one side of a membrane to the other. got7fsn_ti nucleotide-sulphate transporter activity GO:0005341 molecular_function owl:Class
GO:0015116 biolink:NamedThing sulfate transmembrane transporter activity Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other. got7fsn_ti sulphate transporter activity|sulfate permease activity RHEA:34983|Reactome:R-HSA-427555|Reactome:R-HSA-8875871|Reactome:R-HSA-3560789 molecular_function owl:Class
GO:0033803 biolink:NamedThing kaempferol 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H(+) + kaempferide. got7fsn_ti S-adenosyl-L-methionine:kaempferol 4'-O-methyltransferase activity|S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity|F 4'-OMT RHEA:15105|KEGG_REACTION:R06807|EC:2.1.1.155|MetaCyc:2.1.1.155-RXN molecular_function owl:Class
GO:0008516 biolink:NamedThing hexose uniporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in). got7fsn_ti molecular_function owl:Class
GO:0015149 biolink:NamedThing hexose transmembrane transporter activity Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. got7fsn_ti Reactome:R-HSA-189242|Reactome:R-HSA-5638222 molecular_function owl:Class
GO:0070051 biolink:NamedThing fibrinogen binding Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade. got7fsn_ti molecular_function owl:Class
GO:0002227 biolink:NamedThing innate immune response in mucosa Any process of the innate immune response that takes place in the mucosal tissues. got7fsn_ti biological_process owl:Class
GO:0008715 biolink:NamedThing CDP-diacylglycerol diphosphatase activity Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+). got7fsn_ti CDP-diacylglycerol phosphatidylhydrolase activity|CDP-diacylglycerol pyrophosphatase activity|CDP diacylglycerol hydrolase activity|cytidine diphosphodiacylglycerol pyrophosphatase activity EC:3.6.1.26|KEGG_REACTION:R01797|MetaCyc:CDPDIGLYPYPHOSPHA-RXN|RHEA:15221 molecular_function owl:Class
GO:0036189 biolink:NamedThing abieta-7,13-diene hydroxylase activity Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O. got7fsn_ti abietadiene hydroxylase bf 2012-04-19T10:57:05Z MetaCyc:RXN-8507|KEGG_REACTION:R06351|EC:1.14.14.144|RHEA:26217 molecular_function owl:Class
GO:0061596 biolink:NamedThing 3-sulfolactaldehyde reductase activity Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+. got7fsn_ti dph 2014-02-10T10:09:43Z RHEA:40511|EC:1.1.1.373|MetaCyc:RXN-15299 molecular_function owl:Class
GO:0060293 biolink:NamedThing germ plasm Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line. got7fsn_ti Wikipedia:Germ_plasm cellular_component owl:Class
GO:0045495 biolink:NamedThing pole plasm Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo. got7fsn_ti germ plasm|polar plasm cellular_component owl:Class
GO:0036235 biolink:NamedThing acyl deglucuronidation The removal of glucuronic acid from an acyl-glucuronide. got7fsn_ti bf 2012-05-18T04:24:11Z biological_process owl:Class
GO:0036234 biolink:NamedThing deglucuronidation The removal of glucuronic acid from a conjugated substrate. got7fsn_ti bf 2012-05-18T04:23:04Z biological_process owl:Class
GO:0071036 biolink:NamedThing nuclear polyadenylation-dependent snoRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nucleolar RNA (snoRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snoRNA. got7fsn_ti nuclear poly(A)-dependent snoRNA catabolic process krc 2009-07-29T01:04:44Z biological_process owl:Class
GO:0016077 biolink:NamedThing sno(s)RNA catabolic process The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. got7fsn_ti sRNA catabolic process|sno(s)RNA breakdown|snoRNA catabolic process|sno(s)RNA degradation|sno(s)RNA catabolism https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0008513 biolink:NamedThing secondary active organic cation transmembrane transporter activity Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. got7fsn_ti organic cation porter activity|polyspecific organic cation transmembrane transporter activity GO:0015354 Reactome:R-HSA-549241 molecular_function owl:Class
GO:0015101 biolink:NamedThing organic cation transmembrane transporter activity Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. got7fsn_ti Reactome:R-HSA-561072|Reactome:R-HSA-549304|Reactome:R-HSA-561054|Reactome:R-HSA-2161500|Reactome:R-HSA-549279|Reactome:R-HSA-549129|Reactome:R-HSA-549322 molecular_function owl:Class
GO:0002543 biolink:NamedThing activation of blood coagulation via clotting cascade Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot. got7fsn_ti activation of clotting cascade biological_process owl:Class
GO:0050442 biolink:NamedThing 3-propylmalate synthase activity Catalysis of the reaction: glyoxylate + H(2)O + pentanoyl-CoA = 3-propylmalate + CoA + H(+). got7fsn_ti N-propylmalate synthase activity|pentanoyl-CoA:glyoxylate C-pentanoyltransferase (thioester-hydrolysing, 1-carboxybutyl-forming)|3-(n-propyl)-malate synthase activity|beta-n-propylmalate synthase activity|3-propylmalate glyoxylate-lyase (CoA-pentanoylating) activity RHEA:14457|MetaCyc:3-PROPYLMALATE-SYNTHASE-RXN|EC:2.3.3.12|KEGG_REACTION:R03040 molecular_function owl:Class
GO:0017195 biolink:NamedThing N-terminal peptidyl-lysine N2-acetylation The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed. got7fsn_ti RESID:AA0048 biological_process owl:Class
GO:0018076 biolink:NamedThing N-terminal peptidyl-lysine acetylation The acetylation of the N-terminal lysine of proteins. got7fsn_ti biological_process owl:Class
GO:2001029 biolink:NamedThing regulation of cellular glucuronidation Any process that modulates the frequency, rate or extent of cellular glucuronidation. got7fsn_ti regulation of cellular glucuronoside biosynthesis|regulation of cellular glucuronide biosynthetic process|regulation of cellular glucuronoside biosynthetic process|regulation of cellular glucuronide biosynthesis rl 2011-08-22T01:10:52Z biological_process owl:Class
GO:0042809 biolink:NamedThing vitamin D receptor binding Binding to a vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. got7fsn_ti VDR binding|calciferol receptor binding molecular_function owl:Class
GO:0044493 biolink:NamedThing envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism. got7fsn_ti jl 2012-02-01T01:26:59Z biological_process owl:Class
GO:0044492 biolink:NamedThing envenomation resulting in modulation of voltage-gated sodium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism. got7fsn_ti jl 2012-02-01T01:23:04Z biological_process owl:Class
GO:0098847 biolink:NamedThing sequence-specific single stranded DNA binding Binding to single-stranded DNA of a specific nucleotide composition. got7fsn_ti molecular_function owl:Class
GO:0003697 biolink:NamedThing single-stranded DNA binding Binding to single-stranded DNA. got7fsn_ti ssDNA binding Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA. GO:0003698|GO:0003699 molecular_function owl:Class
GO:0039680 biolink:NamedThing actin-dependent intracellular transport of virus towards nucleus The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments. got7fsn_ti actin-dependent intracellular transport of viral material towards nucleus|actin-dependent inwards viral transport bf 2013-10-10T11:24:56Z VZ:991 biological_process owl:Class
GO:0075520 biolink:NamedThing actin-dependent intracellular transport of virus The directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions. got7fsn_ti actin-dependent intracellular transport of viral material jl 2011-08-03T01:45:55Z VZ:991 biological_process owl:Class
GO:0036217 biolink:NamedThing dGTP diphosphatase activity Catalysis of the reaction: dGTP + H2O = dGMP + diphosphate. got7fsn_ti 2'-deoxyguanosine 5'-triphosphate diphosphohydrolase bf 2012-05-08T01:47:59Z KEGG_REACTION:R01855|RHEA:28362 molecular_function owl:Class
GO:0003267 biolink:NamedThing canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation|canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation|canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation|canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation dph 2009-10-15T02:36:08Z biological_process owl:Class
GO:0140662 biolink:NamedThing ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21660 pg 2021-06-19T16:28:34Z molecular_function owl:Class
GO:0044183 biolink:NamedThing protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process. got7fsn_ti chaperone activity|protein binding involved in protein folding jl 2009-09-25T11:33:48Z Reactome:R-HSA-9018785 molecular_function owl:Class
GO:0150088 biolink:NamedThing multiple synapse bouton, contacting multiple dendrites A single axon terminal bouton making contact onto two or more dendritic spines protruding from multiple dendrites. got7fsn_ti type 2 multiple-synapse bouton|type 2 multisynaptic bouton|type 2 multiple spine synapse bouton|type 2 multi-synaptic bouton|type 2 multisynapse bouton|type 2 multi-synapse bouton|MSB2 bc 2018-08-08T13:31:43Z cellular_component owl:Class
GO:0008299 biolink:NamedThing isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. got7fsn_ti polyisoprenoid synthesis|isoprenoid anabolism|polyterpene biosynthetic process|polyisoprenoid biosynthetic process|isoprenoid biosynthesis|isoprenoid synthesis|polyisoprenoid formation|polyisoprenoid anabolism|polyisoprenoid biosynthesis|polyterpene biosynthesis|isoprenoid formation GO:0009241 MetaCyc:POLYISOPRENSYN-PWY biological_process owl:Class
GO:0110103 biolink:NamedThing RNA polymerase II termination complex A conserved protein complex capable of 5'-3' exoribonuclease activity. It is able to promote RNA polymerase II (RNAPII) transcription termination by degrading pre-mRNA from the newly formed 5' phosphorylated end. got7fsn_ti TXT complex In S. cerevisiae, this complex is formed by RAI1 and RAT1; in H. sapiens it is formed by Twi12, Xrn2 and Tan1. kmv 2018-03-16T18:55:17Z cellular_component owl:Class
GO:1905354 biolink:NamedThing exoribonuclease complex A protein complex which is capable of exoribonuclease activity. got7fsn_ti An example of this is DIS3 in human (Q9Y2L1) in PMID:17174896 (inferred from direct assay). bhm 2016-08-08T10:18:29Z cellular_component owl:Class
GO:0034271 biolink:NamedThing phosphatidylinositol 3-kinase complex, class III, type I A class III phosphatidylinositol 3-kinase complex that is involved in autophagy. In budding yeast, this complex consists of Vps30p, Vps34p, Apg14p and Vps15p. got7fsn_ti phosphatidylinositol 3-kinase complex I|autophagy-specific phosphatidylinositol 3-kinase (PtdIns3K) complex|PtdIns-3-kinase complex I Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. cellular_component owl:Class
GO:0035032 biolink:NamedThing phosphatidylinositol 3-kinase complex, class III A phosphatidylinositol 3-kinase complex that contains a catalytic class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Additional adaptor proteins may be present. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI). got7fsn_ti class III PI3K complex|phosphoinositide 3-kinase complex, class III cellular_component owl:Class
GO:0007518 biolink:NamedThing myoblast fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0001709 biolink:NamedThing cell fate determination A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. got7fsn_ti Wikipedia:Cell_fate_determination biological_process owl:Class
GO:0034498 biolink:NamedThing early endosome to Golgi transport The directed movement of substances from early endosomes to the Golgi. got7fsn_ti PGE to Golgi transport|post-Golgi endosome to Golgi transport biological_process owl:Class
GO:0043121 biolink:NamedThing neurotrophin binding Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. got7fsn_ti neurotrophin 3 binding|neurotrophin-4/5 binding|neurotrophic factor binding|NT-3 binding|NT-4 binding|neurotrophin 4/5 binding|neurotrophin TRKC receptor activity|neurotrophin TRKB receptor activity|NT-4/5 binding|NT 4/5 binding|neurotrophin-3 binding|NT-5 binding|NT5 binding|NT3 binding|NT4 binding|neurotrophin TRK receptor activity|neurotrophin TRKA receptor activity Note that mammalian NT-5 was initially named differently from amphibian NT-4 because of sequence differences, but the two genes were later shown to be functionally equivalent [SF:919858]. GO:0048404|GO:0048405 molecular_function owl:Class
GO:0019838 biolink:NamedThing growth factor binding Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. got7fsn_ti neurotrophin TRK receptor activity molecular_function owl:Class
GO:0052201 biolink:NamedThing response to symbiont defenses Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:1990734 biolink:NamedThing astral microtubule anchoring at mitotic spindle pole body Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end. got7fsn_ti vw 2015-04-28T12:15:18Z biological_process owl:Class
GO:0034631 biolink:NamedThing microtubule anchoring at spindle pole body Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end. got7fsn_ti attachment of spindle microtubules to spindle pole body|microtubule anchoring at SPB|attachment of spindle microtubules to SPB biological_process owl:Class
GO:0102516 biolink:NamedThing delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + ferulate + H+. got7fsn_ti MetaCyc:RXN-14448 molecular_function owl:Class
GO:0003300 biolink:NamedThing cardiac muscle hypertrophy The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. got7fsn_ti dph 2009-10-22T10:33:56Z biological_process owl:Class
GO:0014897 biolink:NamedThing striated muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. got7fsn_ti biological_process owl:Class
GO:0010028 biolink:NamedThing xanthophyll cycle A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II. got7fsn_ti Wikipedia:Xanthophyll#Xanthophyll_cycle|MetaCyc:PWY-1141 biological_process owl:Class
GO:0016122 biolink:NamedThing xanthophyll metabolic process The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids. got7fsn_ti xanthophyll metabolism biological_process owl:Class
GO:0035652 biolink:NamedThing clathrin-coated vesicle cargo loading Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle. got7fsn_ti cargo loading into clathrin-coated vesicle bf 2011-01-25T11:00:43Z biological_process owl:Class
GO:0035459 biolink:NamedThing vesicle cargo loading The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle. got7fsn_ti cargo loading into vesicle|cargo selection bf 2010-04-16T01:14:06Z biological_process owl:Class
GO:0036306 biolink:NamedThing embryonic heart tube elongation The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. got7fsn_ti bf 2012-08-08T13:54:37Z biological_process owl:Class
GO:0110018 biolink:NamedThing cap-independent translational initiation of circular RNA The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate circRNA translation. got7fsn_ti cap-independent translational initiation of circRNA kmv 2017-06-08T15:22:35Z biological_process owl:Class
GO:0002190 biolink:NamedThing cap-independent translational initiation The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation. got7fsn_ti hjd 2011-08-11T02:16:05Z biological_process owl:Class
GO:0033000 biolink:NamedThing Fc-gamma receptor I complex A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG. got7fsn_ti immunoglobulin G receptor complex|IgG receptor complex|FcgRI complex cellular_component owl:Class
GO:0034856 biolink:NamedThing 2-hydroxyhexa-2,4-dienoate hydratase activity Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate. got7fsn_ti RHEA:32535|EC:4.2.1.132|UM-BBD_reactionID:r1281 molecular_function owl:Class
GO:0140292 biolink:NamedThing ADP-ribosylserine hydrolase activity Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + ADP-ribose. got7fsn_ti pg 2018-11-22T14:35:39Z molecular_function owl:Class
GO:0048372 biolink:NamedThing lateral mesodermal cell fate commitment The process in which a cell becomes committed to become a lateral mesoderm cell. got7fsn_ti lateral plate mesodermal cell fate commitment|lateral mesoderm cell fate commitment|lateral plate mesoderm cell fate commitment biological_process owl:Class
GO:0052903 biolink:NamedThing N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine. got7fsn_ti non-specific polyamine oxidase activity|N(1)-acetylpolyamine oxidase activity|polyamine oxidase activity EC:1.5.3.17|MetaCyc:RXN-9940|RHEA:25800|KEGG_REACTION:R03899|EC:1.5.3.13|MetaCyc:RXN-12090 molecular_function owl:Class
GO:0036530 biolink:NamedThing protein deglycation, methylglyoxal removal The removal of methylglyoxal from a glycated protein, to form lactate and a deglycated protein. got7fsn_ti protein deglycation of methylglyoxal-glycated protein bf 2016-08-04T10:42:26Z biological_process owl:Class
GO:0009438 biolink:NamedThing methylglyoxal metabolic process The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. got7fsn_ti methylglyoxal metabolism|methylglyoxal pathway|methylglyoxal bypass MetaCyc:METHGLYUT-PWY biological_process owl:Class
GO:0018861 biolink:NamedThing 4-chlorobenzoate-CoA ligase activity Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway. got7fsn_ti 4-chlorobenzoate:CoA ligase activity KEGG_REACTION:R03932|EC:6.2.1.33|RHEA:23220|MetaCyc:6.2.1.33-RXN|UM-BBD_reactionID:r0139 molecular_function owl:Class
GO:0062037 biolink:NamedThing D-loop DNA binding Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind. got7fsn_ti DNA displacement loop binding dph 2018-04-30T15:21:21Z molecular_function owl:Class
GO:0000217 biolink:NamedThing DNA secondary structure binding Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction. got7fsn_ti molecular_function owl:Class
GO:0015361 biolink:NamedThing low-affinity sodium:dicarboxylate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low affinity sodium:dicarboxylate symporter activity|low affinity sodium:dicarboxylate cotransporter activity Reactome:R-HSA-433131 molecular_function owl:Class
GO:0017153 biolink:NamedThing sodium:dicarboxylate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). got7fsn_ti sodium:dicarboxylate cotransporter activity molecular_function owl:Class
GO:0042369 biolink:NamedThing vitamin D catabolic process The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). got7fsn_ti cholecalciferol biosynthesis|calciferol catabolism|vitamin D degradation|ergocalciferol biosynthetic process|calciferol catabolic process|vitamin D catabolism|vitamin D breakdown|ergocalciferol biosynthesis|cholecalciferol biosynthetic process biological_process owl:Class
GO:0042363 biolink:NamedThing fat-soluble vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. got7fsn_ti fat-soluble vitamin degradation|fat-soluble vitamin breakdown|fat-soluble vitamin catabolism biological_process owl:Class
GO:0001733 biolink:NamedThing galactosylceramide sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate. got7fsn_ti 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity|galactocerebroside sulfotransferase activity|galactolipid sulfotransferase activity|glycosphingolipid sulfotransferase activity|cerebroside sulfotransferase activity|GSase|galactosylceramide sulphotransferase activity|glycolipid sulfotransferase activity|3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN|EC:2.8.2.11|RHEA:43304 molecular_function owl:Class
GO:0050694 biolink:NamedThing galactose 3-O-sulfotransferase activity Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc. got7fsn_ti galactose 3-O-sulphotransferase activity|Gal-3-O-sulfotransferase activity molecular_function owl:Class
GO:0070262 biolink:NamedThing peptidyl-serine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine. got7fsn_ti biological_process owl:Class
GO:0102176 biolink:NamedThing cycloeucalenone reductase activity Catalysis of the reaction: cycloeucalenone + NADPH + H+ <=> cycloeucalenol + NADP. got7fsn_ti EC:1.1.1.270|MetaCyc:RXN-11929 molecular_function owl:Class
GO:1990175 biolink:NamedThing EH domain binding Binding to an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R. got7fsn_ti hjd 2013-08-27T20:14:56Z molecular_function owl:Class
GO:0075112 biolink:NamedThing modulation by symbiont of host transmembrane receptor-mediated signal transduction Any process in which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075081". biological_process owl:Class
GO:0075109 biolink:NamedThing modulation by symbiont of host receptor-mediated signal transduction Any process in which the symbiont modulates the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The receptor is defined as a protein on the cell membrane or within the cytoplasm or cell nucleus that binds to a specific molecule (a ligand) such as a neurotransmitter or a hormone or other substance, and initiates the cellular response to the ligand. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont receptor-mediated signal transduction ; GO:0075078". biological_process owl:Class
GO:0030645 biolink:NamedThing glucose catabolic process to butyrate The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum. got7fsn_ti butyrate fermentation|glucose fermentation to butyrate biological_process owl:Class
GO:0006113 biolink:NamedThing fermentation The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP). got7fsn_ti MetaCyc:FERMENTATION-PWY|Wikipedia:Fermentation_(biochemistry) biological_process owl:Class
GO:0072671 biolink:NamedThing mitochondria-associated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions. got7fsn_ti MAD|mitochondria-associated protein catabolic process|mitochondria-associated protein degradation|mitochondrion-associated protein catabolic process mah 2011-02-18T11:53:28Z biological_process owl:Class
GO:0140633 biolink:NamedThing CARD8 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21092 pg 2021-04-09T11:19:51Z biological_process owl:Class
GO:0140632 biolink:NamedThing inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form an inflammasome complex. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21092 pg 2021-04-09T11:11:41Z biological_process owl:Class
GO:0043605 biolink:NamedThing cellular amide catabolic process The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. got7fsn_ti biological_process owl:Class
GO:0102486 biolink:NamedThing dCTP phosphohydrolase activity Catalysis of the reaction: dCTP + 2 H2O = dCMP + 2 hydrogenphosphate + 2 H+. got7fsn_ti EC:3.6.1.5|MetaCyc:RXN-14198 molecular_function owl:Class
GO:0031857 biolink:NamedThing type 1 parathyroid hormone receptor binding Binding to a type 1 parathyroid hormone receptor. got7fsn_ti type 1 parathyroid hormone receptor ligand molecular_function owl:Class
GO:0031856 biolink:NamedThing parathyroid hormone receptor binding Binding to a parathyroid hormone receptor. got7fsn_ti parathyroid hormone receptor ligand molecular_function owl:Class
GO:0033064 biolink:NamedThing XRCC2-RAD51D complex A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast. got7fsn_ti DX2 complex cellular_component owl:Class
GO:0033061 biolink:NamedThing DNA recombinase mediator complex A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange. got7fsn_ti Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly. cellular_component owl:Class
GO:0060530 biolink:NamedThing smooth muscle cell differentiation involved in prostate glandular acinus development The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the prostate glandular acinus. got7fsn_ti biological_process owl:Class
GO:0006884 biolink:NamedThing cell volume homeostasis Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. got7fsn_ti regulation of cell volume biological_process owl:Class
GO:0019725 biolink:NamedThing cellular homeostasis Any process involved in the maintenance of an internal steady state at the level of the cell. got7fsn_ti biological_process owl:Class
GO:0050202 biolink:NamedThing octopamine dehydratase activity Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH(4)(+). got7fsn_ti octopamine hydrolyase activity|octopamine hydro-lyase (deaminating)|octopamine hydro-lyase [deaminating; (4-hydroxyphenyl)acetaldehyde-forming] EC:4.2.1.87|KEGG_REACTION:R03358|RHEA:18173|MetaCyc:OCTOPAMINE-DEHYDRATASE-RXN molecular_function owl:Class
GO:0035486 biolink:NamedThing cytosine/cytosine mispair binding Binding to a double-stranded DNA region containing a C/C mispair. got7fsn_ti C/C mispair binding bf 2010-04-23T10:56:10Z molecular_function owl:Class
GO:0003321 biolink:NamedThing positive regulation of blood pressure by epinephrine-norepinephrine Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine. got7fsn_ti dph 2009-10-29T01:52:50Z biological_process owl:Class
GO:0001993 biolink:NamedThing regulation of systemic arterial blood pressure by norepinephrine-epinephrine The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system. got7fsn_ti norepinephrine-epinephrine blood pressure control|norepinephrine-epinephrine blood pressure regulation|noradrenaline-adrenaline regulation of blood pressure biological_process owl:Class
GO:0061127 biolink:NamedThing negative regulation of positive chemotaxis to cAMP by DIF-1 Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. got7fsn_ti dph 2010-05-17T08:45:03Z biological_process owl:Class
GO:0061120 biolink:NamedThing regulation of positive chemotaxis to cAMP by DIF-1 Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. got7fsn_ti dph 2010-05-17T08:10:20Z biological_process owl:Class
GO:1990845 biolink:NamedThing adaptive thermogenesis The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature. got7fsn_ti sl 2015-08-31T18:19:49Z biological_process owl:Class
GO:0048559 biolink:NamedThing establishment of floral organ orientation The process that determines the orientation of the floral organs with reference to the central axis of the flower. got7fsn_ti biological_process owl:Class
GO:0102157 biolink:NamedThing (R)-sulfopropanediol 2-dehydrogenase activity Catalysis of the reaction: (2R)-3-sulfopropanediol(1-) + NAD <=> 2-oxo-3-hydroxy-propane-1-sulfonate + NADH + H+. got7fsn_ti MetaCyc:RXN-11729 molecular_function owl:Class
GO:0031615 biolink:NamedThing cytosolic proteasome regulatory particle, lid subcomplex The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. got7fsn_ti cellular_component owl:Class
GO:0008541 biolink:NamedThing proteasome regulatory particle, lid subcomplex The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex. got7fsn_ti cellular_component owl:Class
GO:0046310 biolink:NamedThing 1,3-dichloro-2-propanol catabolic process The chemical reactions and pathways resulting in the breakdown of 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. got7fsn_ti 1,3-dichloro-2-propanol catabolism|1,3-dichloro-2-propanol breakdown|1,3-dichloro-2-propanol degradation biological_process owl:Class
GO:0044109 biolink:NamedThing cellular alcohol catabolic process The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell. got7fsn_ti jl 2009-07-15T01:44:27Z biological_process owl:Class
GO:0034238 biolink:NamedThing macrophage fusion The binding and fusion of a macrophage to one or more other cells to form a multinucleated cell. got7fsn_ti biological_process owl:Class
GO:0000768 biolink:NamedThing syncytium formation by plasma membrane fusion The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. got7fsn_ti cell fusion biological_process owl:Class
GO:0070736 biolink:NamedThing protein-glycine ligase activity, initiating Catalysis of the posttranslational transfer of a glycine residue to the gamma-carboxyl group(s) of one or more specific glutamate residues on a target protein. got7fsn_ti protein glycylase activity, initiating mah 2009-06-19T01:56:32Z molecular_function owl:Class
GO:0070735 biolink:NamedThing protein-glycine ligase activity Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target protein. got7fsn_ti protein glycylase activity mah 2009-06-19T01:51:21Z Reactome:R-HSA-8867370 molecular_function owl:Class
GO:0140497 biolink:NamedThing mannan polymerase II complex A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19817 pg 2020-07-22T14:33:57Z cellular_component owl:Class
GO:0000136 biolink:NamedThing mannan polymerase complex A protein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins. got7fsn_ti alpha-1,6-mannosyltransferase complex https://github.com/geneontology/go-ontology/issues/19817 cellular_component owl:Class
GO:0020007 biolink:NamedThing apical complex A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation. got7fsn_ti cellular_component owl:Class
GO:0060492 biolink:NamedThing lung induction The close range interaction of two or more cells or tissues that causes the cells of the foregut to change their fates and specify the development of the lung. got7fsn_ti biological_process owl:Class
GO:0001759 biolink:NamedThing organ induction The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ. got7fsn_ti induction of an organ biological_process owl:Class
GO:0019600 biolink:NamedThing toluene oxidation The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene. got7fsn_ti biological_process owl:Class
GO:0018970 biolink:NamedThing toluene metabolic process The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications. got7fsn_ti methylbenzene metabolic process|toluene metabolism|methylbenzene metabolism biological_process owl:Class
GO:0008635 biolink:NamedThing activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c. got7fsn_ti caspase activation via cytochrome c|activation of caspase activity by cytochrome c biological_process owl:Class
GO:0006919 biolink:NamedThing activation of cysteine-type endopeptidase activity involved in apoptotic process Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. got7fsn_ti activation of caspase activity|caspase activation|activation of metacaspase activity This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase. biological_process owl:Class
GO:0004507 biolink:NamedThing steroid 11-beta-monooxygenase activity Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. got7fsn_ti steroid 11beta-monooxygenase activity|steroid 11beta-hydroxylase activity|steroid 11beta/18-hydroxylase activity|cytochrome P450 CYP11B2|cytochrome p450 XIB1 activity|cytochrome P450 CYP11B1|steroid 11-beta-hydroxylase activity|steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)|oxygenase, steroid 11beta -mono-|steroid 11-beta/18-hydroxylase activity Reactome:R-HSA-5600598|EC:1.14.15.4|Reactome:R-HSA-5580292|Reactome:R-HSA-193997|MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN|Reactome:R-HSA-194017|RHEA:15629 molecular_function owl:Class
GO:0042679 biolink:NamedThing compound eye cone cell fate specification The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti GO:0042678 biological_process owl:Class
GO:0001708 biolink:NamedThing cell fate specification The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. got7fsn_ti biological_process owl:Class
GO:0015643 biolink:NamedThing toxic substance binding Binding to a toxic substance, a poisonous substance that causes damage to biological systems. got7fsn_ti antitoxin activity|lipoprotein antitoxin molecular_function owl:Class
GO:0006937 biolink:NamedThing regulation of muscle contraction Any process that modulates the frequency, rate or extent of muscle contraction. got7fsn_ti biological_process owl:Class
GO:0090257 biolink:NamedThing regulation of muscle system process Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system. got7fsn_ti tb 2010-02-03T11:48:13Z biological_process owl:Class
GO:0015030 biolink:NamedThing Cajal body A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. got7fsn_ti Gems|coiled body|Gemini of coiled bodies Wikipedia:Cajal_body|NIF_Subcellular:nlx_subcell_090901 cellular_component owl:Class
GO:0102255 biolink:NamedThing neo-lambda-carrahexaose hydrolase activity Catalysis of the reaction: neo-lambda-carrahexaose + H2O <=> neo-lambda-carratetraose + neo-lambda-carrabiose. got7fsn_ti MetaCyc:RXN-12428|EC:3.2.1.162 molecular_function owl:Class
GO:0030500 biolink:NamedThing regulation of bone mineralization Any process that modulates the frequency, rate or extent of bone mineralization. got7fsn_ti biological_process owl:Class
GO:0030278 biolink:NamedThing regulation of ossification Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. got7fsn_ti regulation of bone biosynthesis|regulation of bone formation biological_process owl:Class
GO:0046530 biolink:NamedThing photoreceptor cell differentiation The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster. got7fsn_ti GO:0007467 biological_process owl:Class
GO:0030182 biolink:NamedThing neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron. got7fsn_ti biological_process owl:Class
GO:0106033 biolink:NamedThing spine synapse A type of synapse occurring between an axon and a dendritic spine. got7fsn_ti dendritic spine synapse hjd 2017-07-05T19:20:48Z cellular_component owl:Class
GO:0032279 biolink:NamedThing asymmetric synapse A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory. got7fsn_ti Gray's type I synapse cellular_component owl:Class
GO:0010129 biolink:NamedThing anaerobic cyclohexane-1-carboxylate catabolic process The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen. got7fsn_ti anaerobic cyclohexane-1-carboxylate catabolism|anaerobic cyclohexane-1-carboxylate breakdown|anaerobic cyclohexane-1-carboxylate degradation MetaCyc:PWY-301 biological_process owl:Class
GO:0019439 biolink:NamedThing aromatic compound catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. got7fsn_ti aromatic compound breakdown|aromatic hydrocarbon catabolism|aromatic hydrocarbon catabolic process|aromatic compound catabolism|aromatic compound degradation biological_process owl:Class
GO:0036029 biolink:NamedThing protein C inhibitor-KLK3 complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen. got7fsn_ti SERPINA5-KLK3 complex|protein C inhibitor-prostate-specific antigen complex|PCI-KLK3 complex|protein C inhibitor-kallikrein-3 complex|serpin A5-KLK3 complex|plasma serine protease inhibitor-KLK3 complex bf 2011-10-19T02:01:33Z cellular_component owl:Class
GO:0018022 biolink:NamedThing peptidyl-lysine methylation The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative. got7fsn_ti biological_process owl:Class
GO:0006479 biolink:NamedThing protein methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. got7fsn_ti protein amino acid methylation biological_process owl:Class
GO:0060608 biolink:NamedThing cell-cell adhesion involved in neural tube closure The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of the neural tube. got7fsn_ti dph 2009-05-15T09:56:14Z biological_process owl:Class
GO:0060607 biolink:NamedThing cell-cell adhesion involved in sealing an epithelial fold The attachment of one cell to another cell along the edges of two epithelial folds, giving rise to the lumen of an epithelial tube. got7fsn_ti dph 2009-05-15T09:48:49Z biological_process owl:Class
GO:0021747 biolink:NamedThing cochlear nucleus development The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0048857 biolink:NamedThing neural nucleus development The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma. got7fsn_ti biological_process owl:Class
GO:0047904 biolink:NamedThing fructose 5-dehydrogenase activity Catalysis of the reaction: D-fructose + A = 5-dehydro-D-fructose + AH(2). got7fsn_ti fructose 5-dehydrogenase (acceptor)|D-fructose:acceptor 5-oxidoreductase activity|D-fructose dehydrogenase activity|D-fructose:(acceptor) 5-oxidoreductase activity MetaCyc:FRUCTOSE-5-DEHYDROGENASE-RXN|EC:1.1.99.11|RHEA:22304|KEGG_REACTION:R00873 molecular_function owl:Class
GO:0048066 biolink:NamedThing developmental pigmentation The developmental process that results in the deposition of coloring matter in an organism, tissue or cell. got7fsn_ti pigmentation during development biological_process owl:Class
GO:0031669 biolink:NamedThing cellular response to nutrient levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. got7fsn_ti biological_process owl:Class
GO:0002244 biolink:NamedThing hematopoietic progenitor cell differentiation The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. got7fsn_ti haematopoietic progenitor cell differentiation|haemopoietic progenitor cell differentiation|hemopoietic progenitor cell differentiation biological_process owl:Class
GO:0047871 biolink:NamedThing disulfoglucosamine-6-sulfatase activity Catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H(2)O = N-sulfo-D-glucosamine + H(+) + sulfate. got7fsn_ti 6,N-disulfoglucosamine 6-O-sulfohydrolase activity|N,6-O-disulfo-D-glucosamine 6-sulfohydrolase activity|N-sulfoglucosamine-6-sulfatase activity|disulphoglucosamine-6-sulphatase activity KEGG_REACTION:R03216|RHEA:15517|EC:3.1.6.11|MetaCyc:DISULFOGLUCOSAMINE-6-SULFATASE-RXN molecular_function owl:Class
GO:0102363 biolink:NamedThing isoscopoletin-O-methyltransferase activity Catalysis of the reaction: isoscopoletin + S-adenosyl-L-methionine <=> scoparone + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-13475 molecular_function owl:Class
GO:0050743 biolink:NamedThing protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine. got7fsn_ti RESID:AA0352 biological_process owl:Class
GO:0034705 biolink:NamedThing potassium channel complex An ion channel complex through which potassium ions pass. got7fsn_ti cellular_component owl:Class
GO:0062145 biolink:NamedThing L-propargylglycine--L-glutamate ligase activity Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H(+) + L-gamma-glutamyl-L-propargylglycine + phosphate. got7fsn_ti dph 2019-09-02T16:56:59Z RHEA:59896 molecular_function owl:Class
GO:0097722 biolink:NamedThing sperm motility Any process involved in the controlled movement of a sperm cell. got7fsn_ti sperm movement pr 2016-09-01T12:00:45Z biological_process owl:Class
GO:0019686 biolink:NamedThing purine nucleoside interconversion The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside. got7fsn_ti biological_process owl:Class
GO:0015949 biolink:NamedThing nucleobase-containing small molecule interconversion The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule. got7fsn_ti MetaCyc:P1-PWY biological_process owl:Class
GO:0031097 biolink:NamedThing medial cortex A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation. got7fsn_ti medial ring cellular_component owl:Class
GO:1903488 biolink:NamedThing negative regulation of lactation Any process that stops, prevents or reduces the frequency, rate or extent of lactation. got7fsn_ti down regulation of lactation|down-regulation of lactation|downregulation of lactation|inhibition of lactation mr 2014-09-24T14:44:22Z biological_process owl:Class
GO:0072072 biolink:NamedThing kidney stroma development The process whose specific outcome is the progression of the kidney stroma over time, from its formation to the mature structure. The kidney stroma is the mesenchyme of the mature kidney. got7fsn_ti mah 2010-01-25T04:35:36Z biological_process owl:Class
GO:0006995 biolink:NamedThing cellular response to nitrogen starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. got7fsn_ti biological_process owl:Class
GO:0070657 biolink:NamedThing neuromast regeneration The regrowth of a neuromast following its loss or destruction. got7fsn_ti mah 2009-05-28T04:11:44Z biological_process owl:Class
GO:0070655 biolink:NamedThing mechanosensory epithelium regeneration The regrowth of lost or destroyed mechanosensory epithelia. got7fsn_ti mah 2009-05-28T04:05:18Z biological_process owl:Class
GO:0034868 biolink:NamedThing 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1273 molecular_function owl:Class
GO:0032981 biolink:NamedThing mitochondrial respiratory chain complex I assembly The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I. got7fsn_ti mitochondrial complex I assembly|mitochondrial NADH dehydrogenase complex (ubiquinone) assembly biological_process owl:Class
GO:0033108 biolink:NamedThing mitochondrial respiratory chain complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex. got7fsn_ti biological_process owl:Class
GO:0050665 biolink:NamedThing hydrogen peroxide biosynthetic process The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. got7fsn_ti hydrogen peroxide formation|H2O2 biosynthetic process|hydrogen peroxide synthesis|hydrogen peroxide anabolism|hydrogen peroxide generation|hydrogen peroxide biosynthesis biological_process owl:Class
GO:0034567 biolink:NamedThing chromate reductase activity Catalysis of the reaction: chromate = chromium (III). got7fsn_ti UM-BBD_reactionID:r0884|EC:1.97.1.- molecular_function owl:Class
GO:0090592 biolink:NamedThing DNA synthesis involved in DNA replication Synthesis of DNA that is a part of the process of duplicating one or more molecules of DNA. got7fsn_ti tb 2014-06-06T13:54:36Z biological_process owl:Class
GO:0071897 biolink:NamedThing DNA biosynthetic process The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. got7fsn_ti DNA biosynthesis|DNA anabolism|DNA formation|DNA synthesis mah 2010-09-15T02:14:33Z biological_process owl:Class
GO:0031868 biolink:NamedThing prostaglandin F2-alpha receptor binding Binding to a prostaglandin F2-alpha receptor. got7fsn_ti prostanoid FP receptor binding|prostaglandin F2-alpha receptor ligand molecular_function owl:Class
GO:0031862 biolink:NamedThing prostanoid receptor binding Binding to a prostanoid receptor. got7fsn_ti prostanoid receptor ligand molecular_function owl:Class
GO:0016517 biolink:NamedThing interleukin-12 receptor activity Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-12R|IL-12 receptor activity molecular_function owl:Class
GO:0003990 biolink:NamedThing acetylcholinesterase activity Catalysis of the reaction: acetylcholine + H2O = choline + acetate. got7fsn_ti true cholinesterase activity|choline esterase I activity|acetylthiocholinesterase activity|acetyl.beta-methylcholinesterase activity|AcCholE|acetylcholine hydrolase activity|acetylcholine acetylhydrolase activity EC:3.1.1.7|MetaCyc:ACETYLCHOLINESTERASE-RXN|Reactome:R-HSA-372519|RHEA:17561 molecular_function owl:Class
GO:0004104 biolink:NamedThing cholinesterase activity Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion. got7fsn_ti butyrylcholinesterase activity|butyrylcholine esterase activity|BtChoEase activity|anticholineesterase activity|pseudocholinesterase activity|acylcholine acylhydrolase activity|choline esterase II (unspecific) activity|non-specific cholinesterase activity|choline esterase activity|propionylcholinesterase activity|benzoylcholinesterase activity RHEA:21964|MetaCyc:CHOLINESTERASE-RXN|EC:3.1.1.8 molecular_function owl:Class
GO:0051366 biolink:NamedThing protein decanoylation The modification of a protein amino acid by formation of an ester or amide with decanoic acid. got7fsn_ti protein amino acid decanoylation biological_process owl:Class
GO:0043543 biolink:NamedThing protein acylation The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid. got7fsn_ti protein amino acid acylation biological_process owl:Class
GO:0031546 biolink:NamedThing brain-derived neurotrophic factor receptor binding Binding to a brain-derived neurotrophic factor receptor. got7fsn_ti BDNF receptor binding|brain-derived neurotrophic factor ligand molecular_function owl:Class
GO:0005165 biolink:NamedThing neurotrophin receptor binding Binding to a neurotrophin receptor. got7fsn_ti neurotrophin receptor ligand|neurotrophin molecular_function owl:Class
GO:0046009 biolink:NamedThing positive regulation of female receptivity, post-mating Any process that increases the receptiveness of a female to male advances subsequent to mating. got7fsn_ti activation of female receptivity, post-mating|stimulation of female receptivity, post-mating|up-regulation of female receptivity, post-mating|upregulation of female receptivity, post-mating|up regulation of female receptivity, post-mating biological_process owl:Class
GO:0046008 biolink:NamedThing regulation of female receptivity, post-mating Any process that modulates the receptiveness of a female to male advances subsequent to mating. got7fsn_ti biological_process owl:Class
GO:0050892 biolink:NamedThing intestinal absorption Any process in which nutrients are taken up from the contents of the intestine. got7fsn_ti biological_process owl:Class
GO:0022600 biolink:NamedThing digestive system process A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class
GO:0070146 biolink:NamedThing mitochondrial aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA in a mitochondrion, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0045263 biolink:NamedThing proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. got7fsn_ti hydrogen-transporting ATP synthase, coupling factor CF(0)|hydrogen-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase complex, coupling factor F(0)|hydrogen-transporting ATP synthase, F0 sector cellular_component owl:Class
GO:0033177 biolink:NamedThing proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. got7fsn_ti cellular_component owl:Class
GO:0050146 biolink:NamedThing nucleoside phosphotransferase activity Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate. got7fsn_ti nucleotide:2'-nucleoside 5'-phosphotransferase activity|nucleotide:3'-deoxynucleoside 5'-phosphotransferase activity|nucleotide:nucleoside 5'-phosphotransferase activity|nonspecific nucleoside phosphotransferase activity MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN|RHEA:19961|Reactome:R-HSA-2162066|EC:2.7.1.77 molecular_function owl:Class
GO:0019205 biolink:NamedThing nucleobase-containing compound kinase activity Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. got7fsn_ti nucleobase, nucleoside, nucleotide kinase activity molecular_function owl:Class
GO:0042258 biolink:NamedThing molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide. got7fsn_ti RESID:AA0319 biological_process owl:Class
GO:0120140 biolink:NamedThing negative regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. got7fsn_ti krc 2018-03-22T16:32:59Z biological_process owl:Class
GO:0010921 biolink:NamedThing regulation of phosphatase activity Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. got7fsn_ti biological_process owl:Class
GO:0000184 biolink:NamedThing nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. got7fsn_ti nuclear mRNA catabolic process, nonsense-mediated decay|mRNA breakdown, nonsense-mediated decay|mRNA catabolism, nonsense-mediated|mRNA catabolic process, nonsense-mediated|mRNA degradation, nonsense-mediated decay|nonsense-mediated mRNA decay Wikipedia:Nonsense-mediated_mRNA_decay|Wikipedia:Nonsense-mediated_decay biological_process owl:Class
GO:0000956 biolink:NamedThing nuclear-transcribed mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells. got7fsn_ti nuclear mRNA breakdown|nuclear mRNA catabolism|nuclear mRNA degradation biological_process owl:Class
GO:0031872 biolink:NamedThing type 1 proteinase activated receptor binding Binding to a type 1 proteinase activated receptor. got7fsn_ti type 1 proteinase activated receptor ligand|thrombin receptor binding molecular_function owl:Class
GO:0031871 biolink:NamedThing proteinase activated receptor binding Binding to a proteinase activated receptor. got7fsn_ti proteinase activated receptor ligand molecular_function owl:Class
GO:0021775 biolink:NamedThing smoothened signaling pathway involved in ventral spinal cord interneuron specification The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate. got7fsn_ti hedgehog signaling pathway involved in ventral spinal cord interneuron specification|hh signaling pathway involved in ventral spinal cord interneuron specification|smoothened signalling pathway involved in ventral spinal cord interneuron specification biological_process owl:Class
GO:0021910 biolink:NamedThing smoothened signaling pathway involved in ventral spinal cord patterning The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. got7fsn_ti hh signaling pathway involved in ventral spinal cord patterning|hedgehog signaling pathway involved in ventral spinal cord patterning|smoothened signalling pathway in ventral spinal cord patterning biological_process owl:Class
GO:0009299 biolink:NamedThing mRNA transcription The cellular synthesis of messenger RNA (mRNA) from a DNA template. got7fsn_ti mRNA synthesis|cellular mRNA transcription|mRNA biosynthesis|mRNA biosynthetic process GO:0061023 biological_process owl:Class
GO:0006351 biolink:NamedThing transcription, DNA-templated The cellular synthesis of RNA on a template of DNA. got7fsn_ti transcription|cellular transcription, DNA-dependent|DNA-dependent transcription|transcription, DNA-dependent|transcription regulator activity|cellular transcription GO:0061018|GO:0006350|GO:0061022 Wikipedia:Transcription_(genetics) biological_process owl:Class
GO:0036513 biolink:NamedThing Derlin-1 retrotranslocation complex A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel. got7fsn_ti Derlin-1 protein dislocation complex|Derlin-1 complex|Derlin-1 retrotranslocon|Derlin-1 retro-translocation complex|ERAD protein dislocation complex The Derlin-1 retrotranslocation complex is likely to assemble in steps, thereby containing different components at different stages of the retrotranslocation process. bf 2015-07-01T10:17:30Z cellular_component owl:Class
GO:0009594 biolink:NamedThing detection of nutrient The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of nutrients|detection of nutrients|nutrient sensing biological_process owl:Class
GO:0097422 biolink:NamedThing tubular endosome A network of fine tubules in the vicinity of the Golgi complex and around the centriole. got7fsn_ti coated tip pr 2012-11-07T13:36:26Z NIF_Subcellular:sao1570660411|NIF_Subcellular:sao694815499 cellular_component owl:Class
GO:0002207 biolink:NamedThing gene conversion of immunoglobulin genes involved in immune response The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response. got7fsn_ti gene conversion of antibody genes during immune response|gene conversion of immunoglobulin genes during immune response biological_process owl:Class
GO:0002208 biolink:NamedThing somatic diversification of immunoglobulins involved in immune response The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response. got7fsn_ti somatic diversification of immunoglobulins during immune response|somatic diversification of antibodies during immune response biological_process owl:Class
GO:0008419 biolink:NamedThing RNA lariat debranching enzyme activity Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide. got7fsn_ti molecular_function owl:Class
GO:0016891 biolink:NamedThing endoribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. got7fsn_ti EC:3.1.26.- molecular_function owl:Class
GO:0120083 biolink:NamedThing rough endoplasmic reticulum cisterna A subcompartment of the rough endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity. got7fsn_ti krc 2017-07-05T23:38:49Z cellular_component owl:Class
GO:0008195 biolink:NamedThing phosphatidate phosphatase activity Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. got7fsn_ti 3-sn-phosphatidate phosphohydrolase activity|phosphatic acid phosphohydrolase activity|phosphatic acid phosphatase activity|acid phosphatidyl phosphatase activity|phosphatidic acid phosphatase activity|phosphatidate phosphohydrolase activity GO:0004606 EC:3.1.3.4|RHEA:27429|Reactome:R-HSA-390329|Reactome:R-HSA-1483203|Reactome:R-HSA-163750|Reactome:R-HSA-75899|Reactome:R-HSA-6797630|Reactome:R-HSA-163689|MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN|Reactome:R-HSA-2029468|Reactome:R-HSA-5221130|Reactome:R-HSA-164056|Reactome:R-HSA-163688 molecular_function owl:Class
GO:0042131 biolink:NamedThing thiamine phosphate phosphatase activity Catalysis of the reaction: thiamine phosphate + H2O = thiamine + phosphate. got7fsn_ti thiamin monophosphate phosphatase|thiamin phosphate phosphatase activity|ThMPase molecular_function owl:Class
GO:0003993 biolink:NamedThing acid phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. got7fsn_ti acid phosphomonoesterase activity|glycerophosphatase activity|orthophosphoric-monoester phosphohydrolase (acid optimum)|acid phosphomonoester hydrolase activity|uteroferrin|acid phosphohydrolase activity|phosphomonoesterase activity|phosphate-monoester phosphohydrolase (acid optimum)|acid monophosphatase activity|acid nucleoside diphosphate phosphatase activity Reactome:R-HSA-196950|EC:3.1.3.2|MetaCyc:ACID-PHOSPHATASE-RXN molecular_function owl:Class
GO:0071781 biolink:NamedThing endoplasmic reticulum cisternal network A subcompartment of the endoplasmic reticulum consisting of flattened, disc-shaped domains known as cisternae. These are typically found close to the nucleus and are generally more prominent in secretory cells. got7fsn_ti ER cisternal network mah 2010-09-01T01:29:54Z cellular_component owl:Class
GO:0031984 biolink:NamedThing organelle subcompartment A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle. got7fsn_ti suborganelle compartment Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles. cellular_component owl:Class
GO:0010317 biolink:NamedThing pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity. got7fsn_ti PFK complex, alpha-subunit cellular_component owl:Class
GO:0031930 biolink:NamedThing mitochondria-nucleus signaling pathway A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function. got7fsn_ti retrograde response|mitochondrial signaling pathway|mitochondria-nucleus signal transduction|mitochondrial signalling pathway biological_process owl:Class
GO:0045719 biolink:NamedThing negative regulation of glycogen biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. got7fsn_ti negative regulation of glycogen biosynthesis|down regulation of glycogen biosynthetic process|inhibition of glycogen biosynthetic process|negative regulation of glycogen synthesis|negative regulation of glycogen anabolism|downregulation of glycogen biosynthetic process|negative regulation of glycogen formation|down-regulation of glycogen biosynthetic process biological_process owl:Class
GO:0018272 biolink:NamedThing protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine. got7fsn_ti RESID:AA0119 biological_process owl:Class
GO:0018352 biolink:NamedThing protein-pyridoxal-5-phosphate linkage The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate. got7fsn_ti biological_process owl:Class
GO:0003291 biolink:NamedThing atrial septum intermedium morphogenesis The process in which anatomical structure of an atrial septum intermedium is generated and organized. got7fsn_ti dph 2009-10-20T10:35:04Z biological_process owl:Class
GO:0060413 biolink:NamedThing atrial septum morphogenesis The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another. got7fsn_ti interatrial septum morphogenesis GO:0003287 biological_process owl:Class
GO:0003838 biolink:NamedThing sterol 24-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. got7fsn_ti S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity|S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity|delta24-sterol methyltransferase activity|S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity|delta24-methyltransferase activity|sterol 24C methyltransferase activity|delta(24)-methyltransferase activity|phytosterol methyltransferase activity|delta(24)-sterol methyltransferase activity|delta(24)-sterol C-methyltransferase activity|SMT1 activity|S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity|S-adenosyl-4-methionine:sterol delta24-methyltransferase activity|zymosterol-24-methyltransferase activity|24-sterol C-methyltransferase activity https://github.com/geneontology/go-ontology/issues/20399 GO:0102101 MetaCyc:RXN-11201|EC:2.1.1.41|RHEA:21128|MetaCyc:RXN3O-178 molecular_function owl:Class
GO:0140602 biolink:NamedThing nucleolar ring Ring-like structures located at the nucleolar periphery where several nuclear factors are reversibly aggregated and sequestered during acute heat stress. got7fsn_ti NuRs https://github.com/geneontology/go-ontology/issues/20579 pg 2021-02-12T15:38:17Z cellular_component owl:Class
GO:0042405 biolink:NamedThing nuclear inclusion body An intranuclear focus at which aggregated proteins have been sequestered. got7fsn_ti cellular_component owl:Class
GO:0031957 biolink:NamedThing very long-chain fatty acid-CoA ligase activity Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22. got7fsn_ti very-long-chain fatty acid-CoA ligase activity|very-long-chain fatty acid activation|very-long-chain-fatty-acid-CoA ligase activity Reactome:R-HSA-8875077|Reactome:R-HSA-5696007|Reactome:R-HSA-5695957 molecular_function owl:Class
GO:1990914 biolink:NamedThing integral component of periplasmic side of plasma membrane The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane. got7fsn_ti An example of this is hyaA in E. coli (P69739) in PMID:23260654 (inferred from direct assay). bhm 2015-12-09T14:38:57Z cellular_component owl:Class
GO:0097144 biolink:NamedThing BAX complex An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:45:15Z cellular_component owl:Class
GO:0009845 biolink:NamedThing seed germination The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis. got7fsn_ti Wikipedia:Germination#Seed_germination biological_process owl:Class
GO:0080089 biolink:NamedThing sinapoyl spermidine:sinapoyl CoA N-acyltransferase activity Catalysis of the transfer of a sinapoyl group to a nitrogen atom on a sinapoyl spermidine molecule resulting in the formation of a disinapoyl spermidine derivative. got7fsn_ti dhl 2009-04-22T03:27:55Z molecular_function owl:Class
GO:0050714 biolink:NamedThing positive regulation of protein secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. got7fsn_ti upregulation of protein secretion|up regulation of protein secretion|stimulation of protein secretion|activation of protein secretion|up-regulation of protein secretion biological_process owl:Class
GO:0018441 biolink:NamedThing iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase. got7fsn_ti iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide RESID:AA0300 biological_process owl:Class
GO:0045326 biolink:NamedThing protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine. got7fsn_ti DNA-protein covalent cross-linking via the 3'-end to peptidyl-tyrosine RESID:AA0323 biological_process owl:Class
GO:0010425 biolink:NamedThing DNA methylation on cytosine within a CNG sequence The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide. got7fsn_ti cytosine methylation within a CNG sequence biological_process owl:Class
GO:0032776 biolink:NamedThing DNA methylation on cytosine The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule. got7fsn_ti cytosine methylation biological_process owl:Class
GO:0035889 biolink:NamedThing otolith tethering The attachment of a developing otolith to the kinocilia of tether cells in the inner ear. got7fsn_ti bf 2011-06-14T02:28:14Z biological_process owl:Class
GO:0072554 biolink:NamedThing blood vessel lumenization The process in which a developing blood vessel forms an endothelial lumen through which blood will flow. got7fsn_ti mah 2011-01-25T05:19:30Z biological_process owl:Class
GO:0038184 biolink:NamedThing cell surface bile acid receptor signaling pathway A series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti membrane bile acid receptor signaling pathway bf 2013-05-16T11:00:42Z biological_process owl:Class
GO:0055040 biolink:NamedThing periplasmic flagellum Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella. got7fsn_ti cellular_component owl:Class
GO:0009288 biolink:NamedThing bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. got7fsn_ti flagellin-based flagellum cellular_component owl:Class
GO:0047657 biolink:NamedThing alpha-1,3-glucan synthase activity Catalysis of the reaction: UDP-glucose + [alpha-D-glucosyl-(1,3)]n = UDP + [alpha-D-glucosyl-(1,3)]n+1. got7fsn_ti a-1,3-glucan synthase activity|1,3-alpha-D-glucan synthase activity|uridine diphosphoglucose-1,3-alpha-glucan glucosyltransferase activity|UDP-glucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity|1,3-alpha-glucan synthase activity|UDPglucose:alpha-D-(1->3)-glucan 3-alpha-D-glucosyltransferase activity EC:2.4.1.183|RHEA:19749|MetaCyc:ALPHA-13-GLUCAN-SYNTHASE-RXN molecular_function owl:Class
GO:0045549 biolink:NamedThing 9-cis-epoxycarotenoid dioxygenase activity Catalysis of the reactions: a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12'-apo-carotenal; 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al; and 9'-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al. got7fsn_ti VP14|neoxanthin cleavage enzyme|9-cis-epoxycarotenoid 11,12-dioxygenase activity|NCED|nine-cis-epoxycarotenoid dioxygenase activity|PvNCED1|AtNCED3 EC:1.13.11.51 molecular_function owl:Class
GO:0010436 biolink:NamedThing carotenoid dioxygenase activity Catalysis of the oxidative cleavage of carotenoids. got7fsn_ti carotenoid-cleaving dioxygenase molecular_function owl:Class
GO:0036199 biolink:NamedThing cholest-4-en-3-one 26-monooxygenase activity Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate. got7fsn_ti bf 2012-04-20T02:03:05Z RHEA:51564|KEGG_REACTION:R09859|EC:1.14.15.29 molecular_function owl:Class
GO:0042402 biolink:NamedThing cellular biogenic amine catabolic process The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. got7fsn_ti biogenic amine degradation|biogenic amine catabolism|biogenic amine breakdown biological_process owl:Class
GO:0006576 biolink:NamedThing cellular biogenic amine metabolic process The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. got7fsn_ti biogenic amine metabolism biological_process owl:Class
GO:0050310 biolink:NamedThing sulfite dehydrogenase activity Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c. got7fsn_ti sulfite:ferricytochrome-c oxidoreductase activity|sulfite cytochrome c reductase activity|sulfite-cytochrome c oxidoreductase activity|sulphite dehydrogenase activity RHEA:14281|EC:1.8.2.1|MetaCyc:SULFITE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0016669 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome. got7fsn_ti oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor EC:1.8.2.- molecular_function owl:Class
GO:0018207 biolink:NamedThing peptidyl-phenylalanine modification The modification of peptidyl-phenylalanine. got7fsn_ti biological_process owl:Class
GO:0008441 biolink:NamedThing 3'(2'),5'-bisphosphate nucleotidase activity Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. got7fsn_ti 3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity|phosphoadenylate 3'-nucleotidase activity|adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity|3'(2'),5' bisphosphate nucleotidase activity|DPNPase activity|3'-phosphoadenylylsulfate 3'-phosphatase activity RHEA:10040|Reactome:R-HSA-176606|EC:3.1.3.7|Reactome:R-HSA-8953499|MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN molecular_function owl:Class
GO:0008252 biolink:NamedThing nucleotidase activity Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. got7fsn_ti NSP II|nucleotide-specific phosphatase activity|NSP I|nucleotide phosphohydrolase activity|deoxyribonucleoside-activated nucleotidase (DAN)|acid nucleotidase activity|deoxyinosine-activated nucleotidase (DIAN) RHEA:22140|MetaCyc:NUCLEOTIDASE-RXN molecular_function owl:Class
GO:0003428 biolink:NamedThing chondrocyte intercalation involved in growth plate cartilage morphogenesis The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone. got7fsn_ti dph 2009-12-22T11:52:32Z biological_process owl:Class
GO:0035320 biolink:NamedThing imaginal disc-derived wing hair site selection Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally. got7fsn_ti wing hair site selection|prehair localization biological_process owl:Class
GO:0022606 biolink:NamedThing establishment of proximal/distal cell polarity The specification and formation of the polarity of a cell along its proximal/distal axis. got7fsn_ti biological_process owl:Class
GO:0033036 biolink:NamedThing macromolecule localization Any process in which a macromolecule is transported to, or maintained in, a specific location. got7fsn_ti macromolecule localisation biological_process owl:Class
GO:0051179 biolink:NamedThing localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. got7fsn_ti establishment and maintenance of substance location|single organism localization|localisation|establishment and maintenance of position|establishment and maintenance of substrate location|establishment and maintenance of cellular component location|single-organism localization|establishment and maintenance of localization jl 2013-12-18T13:51:04Z GO:1902578 biological_process owl:Class
GO:0102832 biolink:NamedThing verbascose galactinol:ajugose galactosyltransferase activity Catalysis of the reaction: verbascose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> ajugose + myo-inositol. got7fsn_ti MetaCyc:RXN-8288 molecular_function owl:Class
GO:0061863 biolink:NamedThing microtubule plus end polymerase Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversable depending on the availability of dimers. got7fsn_ti dph 2017-04-07T17:36:57Z molecular_function owl:Class
GO:0048369 biolink:NamedThing lateral mesoderm morphogenesis The process in which the anatomical structures of the lateral mesoderm are generated and organized. got7fsn_ti lateral plate mesoderm morphogenesis biological_process owl:Class
GO:0043620 biolink:NamedThing regulation of DNA-templated transcription in response to stress Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti regulation of DNA-dependent transcription in response to stress biological_process owl:Class
GO:0009917 biolink:NamedThing sterol 5-alpha reductase activity Catalysis of the removal of a C-5 double bond in the B ring of a sterol. got7fsn_ti molecular_function owl:Class
GO:0010675 biolink:NamedThing regulation of cellular carbohydrate metabolic process Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. got7fsn_ti biological_process owl:Class
GO:0006109 biolink:NamedThing regulation of carbohydrate metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates. got7fsn_ti regulation of carbohydrate metabolism biological_process owl:Class
GO:0043603 biolink:NamedThing cellular amide metabolic process The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. got7fsn_ti amide metabolism biological_process owl:Class
GO:0048890 biolink:NamedThing lateral line ganglion development The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear. got7fsn_ti gLL ganglion development biological_process owl:Class
GO:0061550 biolink:NamedThing cranial ganglion development The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure. got7fsn_ti cranial ganglia development dph 2013-07-10T08:40:14Z biological_process owl:Class
GO:0030255 biolink:NamedThing protein secretion by the type IV secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system. got7fsn_ti type IV protein secretion system|protein secretion by the type IV protein secretion system|protein secretion by the T4SS Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'. biological_process owl:Class
GO:0071806 biolink:NamedThing protein transmembrane transport The process in which a protein is transported across a membrane. got7fsn_ti protein membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-09-03T02:54:26Z biological_process owl:Class
GO:0036332 biolink:NamedThing placental growth factor-activated receptor activity Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti PlGF-activated receptor activity|placental growth factor receptor activity|PlGF receptor activity bf 2012-09-05T09:34:37Z molecular_function owl:Class
GO:0043452 biolink:NamedThing cellular alkyne metabolic process The chemical reactions and pathways involving an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells. got7fsn_ti alkyne metabolism biological_process owl:Class
GO:0044237 biolink:NamedThing cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. got7fsn_ti intermediary metabolism|cellular metabolism biological_process owl:Class
GO:0061257 biolink:NamedThing mesonephric glomerular visceral epithelial cell development The process whose specific outcome is the progression of a mesonephric glomerular visceral epithelial cell over time, from its formation to the mature structure. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. got7fsn_ti dph 2010-08-30T02:10:40Z biological_process owl:Class
GO:0061251 biolink:NamedThing mesonephric glomerular epithelial cell development The process whose specific outcome is the progression of a mesonephric glomerular epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. got7fsn_ti dph 2010-08-30T01:20:45Z biological_process owl:Class
GO:0009748 biolink:NamedThing hexokinase-independent signaling A series of molecular signals mediated by hexose and independent of hexokinase. got7fsn_ti hexokinase-independent signalling biological_process owl:Class
GO:0034042 biolink:NamedThing 5-formyluracil DNA N-glycosylase activity Catalysis of the removal of 5-formyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. got7fsn_ti 5-foU DNA N-glycosylase activity molecular_function owl:Class
GO:0000703 biolink:NamedThing oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. got7fsn_ti endonuclease III|endonuclease VIII activity|DNA glycosylase/beta-lyase|endodeoxyribonuclease III|bifunctional DNA glycosylase|DNA glycosylase/AP-lyase|pyrimidine-specific oxidized base lesion DNA N-glycosylase activity|oxidized pyrimidine base lesion DNA N-glycosylase activity Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. GO:0019004 Reactome:R-HSA-110227|Reactome:R-HSA-110226|Reactome:R-HSA-110224 molecular_function owl:Class
GO:0098631 biolink:NamedThing cell adhesion mediator activity The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell. got7fsn_ti cell adhesion molecule|protein binding involved in cell adhesion molecular_function owl:Class
GO:0018837 biolink:NamedThing 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate. got7fsn_ti UM-BBD_reactionID:r0502 molecular_function owl:Class
GO:0052692 biolink:NamedThing raffinose alpha-galactosidase activity Catalysis of the reaction: raffinose + H2O = alpha-D-galactose + sucrose. got7fsn_ti alkaline alpha-galactosidase activity|raffinose-specific alkaline alpha-galactosidase activity|raffinose galactohydrolase activity MetaCyc:RXN-11502|KEGG_REACTION:R01103|EC:3.2.1.22 molecular_function owl:Class
GO:0004557 biolink:NamedThing alpha-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase. got7fsn_ti melibiase activity|alpha-D-galactoside galactohydrolase activity|alpha-galactoside galactohydrolase activity|alpha-D-galactosidase activity|alpha-galactosidase A MetaCyc:ALPHAGALACTOSID-RXN|Reactome:R-HSA-1605736|RHEA:28663|EC:3.2.1.22 molecular_function owl:Class
GO:0003991 biolink:NamedThing acetylglutamate kinase activity Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate. got7fsn_ti N-acetylglutamate phosphokinase activity|acetylglutamate phosphokinase activity|N-acetylglutamate 5-phosphotransferase activity|N-acetylglutamic 5-phosphotransferase activity|ATP:N-acetyl-L-glutamate 5-phosphotransferase activity|N-acetylglutamate kinase activity RHEA:14629|EC:2.7.2.8|MetaCyc:ACETYLGLUTKIN-RXN molecular_function owl:Class
GO:0045018 biolink:NamedThing retrograde transport, vacuole to Golgi The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment. got7fsn_ti retrograde transport from the vacuole biological_process owl:Class
GO:0007034 biolink:NamedThing vacuolar transport The directed movement of substances into, out of or within a vacuole. got7fsn_ti biological_process owl:Class
GO:0090587 biolink:NamedThing protein-phosphocysteine-glucosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0007271 biolink:NamedThing synaptic transmission, cholinergic The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. got7fsn_ti cholinergic synaptic transmission biological_process owl:Class
GO:0004686 biolink:NamedThing elongation factor-2 kinase activity Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate. got7fsn_ti eEF-2 kinase activity|calmodulin-dependent protein kinase III activity|eEF2 kinase activity|ATP:elongation factor 2 phosphotransferase activity|CaM kinase III activity|eEF2K|STK19|elongation factor 2 kinase activity|eukaryotic elongation factor 2 kinase activity|Ca/CaM-kinase III activity|EF2K EC:2.7.11.20|RHEA:21436|MetaCyc:2.7.11.20-RXN molecular_function owl:Class
GO:0042316 biolink:NamedThing penicillin metabolic process The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus. got7fsn_ti penicillin metabolism biological_process owl:Class
GO:0048621 biolink:NamedThing post-embryonic digestive tract morphogenesis The process, occurring during the post-embryonic phase, by which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. got7fsn_ti post-embryonic gut morphogenesis biological_process owl:Class
GO:1990003 biolink:NamedThing inosine-diphosphatase activity Catalysis of the reaction: IDP + H2O = IMP + phosphate. got7fsn_ti inosine diphosphatase activity|IDP phosphatase activity|inosine-diphosphatase activity|IDPase activity jl 2012-12-05T16:46:52Z GO:0090450 Reactome:R-HSA-2509816|EC:3.6.1.64|RHEA:35207 molecular_function owl:Class
GO:0098519 biolink:NamedThing nucleotide phosphatase activity, acting on free nucleotides Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate. got7fsn_ti nucleotide phosphatase activity To be used for NTP->NDP or NDP -> NMP. For nucleotide -> nucleoside (all phosphates removed) use nucleotidase. dos 2013-09-26T11:04:45Z molecular_function owl:Class
GO:0016417 biolink:NamedThing S-acyltransferase activity Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0032024 biolink:NamedThing positive regulation of insulin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. got7fsn_ti up regulation of insulin secretion|activation of insulin secretion|upregulation of insulin secretion|stimulation of insulin secretion|up-regulation of insulin secretion biological_process owl:Class
GO:0090277 biolink:NamedThing positive regulation of peptide hormone secretion Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. got7fsn_ti tb 2010-02-05T02:56:39Z biological_process owl:Class
GO:0048521 biolink:NamedThing negative regulation of behavior Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. got7fsn_ti inhibition of behavior|down regulation of behavior|down-regulation of behavior|downregulation of behavior biological_process owl:Class
GO:0031126 biolink:NamedThing sno(s)RNA 3'-end processing Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea. got7fsn_ti sno(s)RNA 3' end processing|sRNA 3'-end processing|snoRNA 3'-end processing https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0043144 biolink:NamedThing sno(s)RNA processing Any process involved in the conversion of a primary snoRNA family RNA transcript into a mature snoRNA (eukaryota) or sRNA (archaea). got7fsn_ti https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0018044 biolink:NamedThing C-terminal peptidyl-leucine amidation The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0091 biological_process owl:Class
GO:0009501 biolink:NamedThing amyloplast A plastid whose main function is to synthesize and store starch. got7fsn_ti Wikipedia:Amyloplast cellular_component owl:Class
GO:0009536 biolink:NamedThing plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. got7fsn_ti Wikipedia:Plastid cellular_component owl:Class
GO:0050046 biolink:NamedThing delta7-sterol 5(6)-desaturase activity Catalysis of the reaction: a delta(7)-sterol + 2 ferrocytochrome b5 + O2 + 2 H+ -> a delta(5,7)-sterol + 2 ferricytochrome b5 + 2 H2O. got7fsn_ti delta7-sterol-C5(6)-desaturase activity|lathosterol 5-desaturase activity|delta7-sterol 5-desaturase activity|delta7-sterol delta5-dehydrogenase activity|lathosterol oxidase activity|5-DES https://github.com/geneontology/go-ontology/issues/21133 EC:1.14.19.20|RHEA:46556|MetaCyc:1.14.21.6-RXN molecular_function owl:Class
GO:0033291 biolink:NamedThing eukaryotic 80S initiation complex A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region. got7fsn_ti cellular_component owl:Class
GO:0070992 biolink:NamedThing translation initiation complex A ribonucleoprotein complex that contains a ribosome, mRNA, and initiator tRNA; the functional ribosome is at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. got7fsn_ti mah 2009-10-30T01:23:52Z cellular_component owl:Class
GO:0071177 biolink:NamedThing MAML2-RBP-Jkappa-ICN3 complex A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML2-RBP-Jkappa-Notch3 complex mah 2009-11-23T02:48:56Z cellular_component owl:Class
GO:0001695 biolink:NamedThing histamine catabolic process The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. got7fsn_ti histamine degradation|histamine breakdown|histamine catabolism biological_process owl:Class
GO:0042135 biolink:NamedThing neurotransmitter catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. got7fsn_ti neurotransmitter breakdown|neurotransmitter degradation|neurotransmitter catabolism biological_process owl:Class
GO:0036364 biolink:NamedThing transforming growth factor beta1 activation The release of transforming growth factor beta1 (TGF-beta1) from its latent state. got7fsn_ti TGFbeta 1 activation|L-TGF-beta 1 activation|TGFB1 activation|latent-TGF-beta1 activation|transforming growth factor-beta1 activation|TGF-beta 1 activation bf 2012-09-24T10:09:02Z biological_process owl:Class
GO:0036363 biolink:NamedThing transforming growth factor beta activation The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms. got7fsn_ti TGF-beta activation|L-TGF-beta activation|TGFB activation|latent TGF-beta activation|TGFbeta activation|TGF-B activation bf 2012-09-24T10:06:56Z biological_process owl:Class
GO:0036408 biolink:NamedThing histone acetyltransferase activity (H3-K14 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K14 specific) bf 2013-08-21T10:03:10Z molecular_function owl:Class
GO:0007491 biolink:NamedThing sternite morphogenesis The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment. got7fsn_ti biological_process owl:Class
GO:0061232 biolink:NamedThing mesonephric glomerular epithelium development The process whose specific outcome is the progression of the mesonephric glomerular epithelium over time, from its formation to the mature structure. The mesonephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the mesonephros. The mesonephric glomerular epithelium consists of both parietal and visceral epithelium. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. got7fsn_ti dph 2010-08-19T02:49:46Z biological_process owl:Class
GO:0072163 biolink:NamedThing mesonephric epithelium development The process whose specific outcome is the progression of an epithelium in the mesonephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. got7fsn_ti mah 2010-02-26T01:40:43Z biological_process owl:Class
GO:0097291 biolink:NamedThing renal phosphate ion absorption A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. got7fsn_ti renal phosphate absorption pr 2012-04-25T03:34:48Z biological_process owl:Class
GO:0070293 biolink:NamedThing renal absorption A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). got7fsn_ti nephron absorption|renal reabsorption biological_process owl:Class
GO:0003019 biolink:NamedThing central nervous system control of baroreceptor feedback The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris. got7fsn_ti biological_process owl:Class
GO:0140644 biolink:NamedThing neutrophil extracellular trap Extracellular microbicidal structure composed of nuclear chromatin, histones and granular antimicrobial proteins. Histones and several neutrophil granule proteins associated with the DNA framework damage entrapped microorganisms. got7fsn_ti NET https://github.com/geneontology/go-ontology/issues/21416 pg 2021-05-12T07:03:05Z cellular_component owl:Class
GO:0043264 biolink:NamedThing extracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell. got7fsn_ti extracellular non-membrane-enclosed organelle cellular_component owl:Class
GO:0045995 biolink:NamedThing regulation of embryonic development Any process that modulates the frequency, rate or extent of embryonic development. got7fsn_ti biological_process owl:Class
GO:0047826 biolink:NamedThing D-lysine 5,6-aminomutase activity Catalysis of the reaction: D-lysine = 2,5-diaminohexanoate. got7fsn_ti adenosylcobalamin-dependent D-lysine 5,6-aminomutase activity|D-alpha-lysine mutase activity|D-2,6-diaminohexanoate 5,6-aminomutase activity KEGG_REACTION:R02852|EC:5.4.3.4|MetaCyc:D-LYSINE-56-AMINOMUTASE-RXN|RHEA:18241 molecular_function owl:Class
GO:0016869 biolink:NamedThing intramolecular transferase activity, transferring amino groups Catalysis of the transfer of an amino group from one position to another within a single molecule. got7fsn_ti EC:5.4.3.- molecular_function owl:Class
GO:0035472 biolink:NamedThing choriogonadotropin hormone receptor activity Combining with the choriogonadotropin hormone to initiate a change in cell activity. got7fsn_ti CG receptor activity|chorionic gonadotropin hormone receptor|chorio-gonadotrophin receptor activity bf 2010-04-22T04:49:57Z molecular_function owl:Class
GO:0016500 biolink:NamedThing protein-hormone receptor activity Combining with a protein hormone to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0045038 biolink:NamedThing protein import into chloroplast thylakoid membrane The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma. got7fsn_ti protein transport into chloroplast thylakoid membrane|chloroplast thylakoid membrane protein import biological_process owl:Class
GO:0006612 biolink:NamedThing protein targeting to membrane The process of directing proteins towards a membrane, usually using signals contained within the protein. got7fsn_ti protein-membrane targeting|protein membrane targeting biological_process owl:Class
GO:0047110 biolink:NamedThing phenylglyoxylate dehydrogenase (acylating) activity Catalysis of the reaction: CoA + NAD(+) + phenylglyoxylate = benzoyl-CoA + CO(2) + NADH. got7fsn_ti phenylglyoxylate:NAD+ oxidoreductase activity EC:1.2.1.58|KEGG_REACTION:R02450|RHEA:10372|MetaCyc:1.2.1.58-RXN molecular_function owl:Class
GO:0043364 biolink:NamedThing glycyl-radical enzyme activating activity Catalyzes the activation of an enzyme by generating an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM). got7fsn_ti catalysis of free radical formation https://github.com/geneontology/go-ontology/issues/14190 EC:1.97.1.- molecular_function owl:Class
GO:0075522 biolink:NamedThing IRES-dependent viral translational initiation Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation. got7fsn_ti jl 2011-08-03T02:25:03Z VZ:867 biological_process owl:Class
GO:1905555 biolink:NamedThing positive regulation of blood vessel branching Any process that activates or increases the frequency, rate or extent of blood vessel branching. got7fsn_ti activation of branching involved in blood vessel morphogenesis|up regulation of branching involved in blood vessel morphogenesis|positive regulation of branching involved in blood vessel morphogenesis|upregulation of branching involved in blood vessel morphogenesis|activation of patterning of blood vessels|up-regulation of patterning of blood vessels|upregulation of patterning of blood vessels|up regulation of patterning of blood vessels|up-regulation of branching involved in blood vessel morphogenesis nc 2016-10-12T14:19:49Z biological_process owl:Class
GO:1905553 biolink:NamedThing regulation of blood vessel branching Any process that modulates the frequency, rate or extent of blood vessel branching. got7fsn_ti regulation of branching involved in blood vessel morphogenesis nc 2016-10-12T14:19:33Z biological_process owl:Class
GO:0052829 biolink:NamedThing inositol-1,3,4-trisphosphate 1-phosphatase activity Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate. got7fsn_ti ai 2011-11-29T09:58:00Z Reactome:R-HSA-1855232 molecular_function owl:Class
GO:0046030 biolink:NamedThing inositol trisphosphate phosphatase activity Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. got7fsn_ti inositol-1,4,5-trisphosphate phosphatase|IP3 phosphatase activity|IP(3) phosphatase activity molecular_function owl:Class
GO:0007437 biolink:NamedThing adult salivary gland morphogenesis The process in which the anatomical structures of the adult salivary gland are generated and organized. got7fsn_ti biological_process owl:Class
GO:0007435 biolink:NamedThing salivary gland morphogenesis The process in which the anatomical structures of the salivary gland are generated and organized. got7fsn_ti biological_process owl:Class
GO:0044497 biolink:NamedThing positive regulation of blood pressure in other organism A process by which one organism increases the force with which blood travels through the circulatory system of another organism. got7fsn_ti jl 2012-02-01T02:17:21Z biological_process owl:Class
GO:0045777 biolink:NamedThing positive regulation of blood pressure Any process in which the force of blood traveling through the circulatory system is increased. got7fsn_ti up-regulation of blood pressure|up regulation of blood pressure|upregulation of blood pressure|activation of blood pressure|stimulation of blood pressure biological_process owl:Class
GO:0061429 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter by oleic acid Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti dph 2012-02-07T09:54:49Z biological_process owl:Class
GO:0003071 biolink:NamedThing renal system process involved in regulation of systemic arterial blood pressure Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. got7fsn_ti renal control of blood pressure|renal regulation of systemic arterial blood pressure biological_process owl:Class
GO:0052727 biolink:NamedThing capsanthin synthase activity Catalysis of the reaction: antheraxanthin = capsanthin. got7fsn_ti ketoxanthophyll synthase activity|capsanthin-capsorubin synthase activity|CCS ai 2011-08-16T03:09:21Z MetaCyc:RXN-7947|EC:5.3.99.8|RHEA:17373 molecular_function owl:Class
GO:0070137 biolink:NamedThing ubiquitin-like protein-specific endopeptidase activity Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO). got7fsn_ti small conjugating protein-specific endopeptidase activity molecular_function owl:Class
GO:0004197 biolink:NamedThing cysteine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. got7fsn_ti lysosomal cysteine-type endopeptidase|metacaspase activity|caspase activity|thiol endopeptidase activity Reactome:R-HSA-201595|Reactome:R-HSA-2028697|Reactome:R-HSA-211190|MetaCyc:3.4.22.27-RXN|Reactome:R-HSA-201611|Reactome:R-HSA-2562564|Reactome:R-HSA-5660663|Reactome:R-HSA-201639|Reactome:R-HSA-139952|Reactome:R-HSA-9684273|Reactome:R-HSA-418852|Reactome:R-HSA-264871|Reactome:R-HSA-5634228|Reactome:R-HSA-351913|Reactome:R-HSA-201637|Reactome:R-HSA-9694625|Reactome:R-HSA-139898|Reactome:R-HSA-418846|Reactome:R-HSA-9694377|Reactome:R-HSA-202969|Reactome:R-HSA-114252|EC:3.4.22.8|Reactome:R-HSA-211651|EC:3.4.22.-|Reactome:R-HSA-351894|Reactome:R-HSA-202967|Reactome:R-HSA-350319|Reactome:R-HSA-201640|Reactome:R-HSA-933532|Reactome:R-HSA-2130336|MetaCyc:3.4.22.15-RXN|Reactome:R-HSA-9012556|Reactome:R-HSA-9684309|Reactome:R-HSA-351877|Reactome:R-HSA-9684351|Reactome:R-HSA-5357828|Reactome:R-HSA-1678981|EC:3.4.22.41|Reactome:R-HSA-114259|MetaCyc:3.4.22.40-RXN|Reactome:R-HSA-2130706|MetaCyc:3.4.22.14-RXN|Reactome:R-HSA-418845|EC:3.4.22.14|Reactome:R-HSA-9684340|Reactome:R-HSA-352268|Reactome:R-HSA-350318|MetaCyc:3.4.22.16-RXN|Reactome:R-HSA-9603534|Reactome:R-HSA-9686930|Reactome:R-HSA-202939|Reactome:R-HSA-201608|Reactome:R-HSA-2130504|Reactome:R-HSA-2130349|Reactome:R-HSA-350651|Reactome:R-HSA-9684336|EC:3.4.22.38|Reactome:R-HSA-351876|Reactome:R-HSA-212552|Reactome:R-HSA-6814387|Reactome:R-HSA-351901|Reactome:R-HSA-448703|Reactome:R-HSA-202960|Reactome:R-HSA-202947|Reactome:R-HSA-5682377|Reactome:R-HSA-351849|Reactome:R-HSA-211186|Reactome:R-HSA-5681987|MetaCyc:3.4.22.38-RXN|MetaCyc:3.4.22.41-RXN|Reactome:R-HSA-1678920|Reactome:R-HSA-9013895|Reactome:R-HSA-1236948|Reactome:R-HSA-9694551|EC:3.4.22.15|Reactome:R-HSA-351871|Reactome:R-HSA-202917|Reactome:R-HSA-9694732|Reactome:R-HSA-201631|Reactome:R-HSA-201634|Reactome:R-HSA-202966|Reactome:R-HSA-201636|Reactome:R-HSA-3465448|EC:3.4.22.34|Reactome:R-HSA-201628|Reactome:R-HSA-351936|EC:3.4.22.28|Reactome:R-HSA-9694601|Reactome:R-HSA-201630|Reactome:R-HSA-9684352|MetaCyc:3.4.22.34-RXN|EC:3.4.22.1|Reactome:R-HSA-201603|Reactome:R-HSA-201622|Reactome:R-HSA-9697750|EC:3.4.22.40|Reactome:R-HSA-114261|Reactome:R-HSA-9684321|Reactome:R-HSA-9694338|Reactome:R-HSA-201629|Reactome:R-HSA-9693929|Reactome:R-HSA-264865|Reactome:R-HSA-350158|Reactome:R-HSA-9647999|Reactome:R-HSA-2028692|EC:3.4.22.27|Reactome:R-HSA-9694441|EC:3.4.22.16|MetaCyc:3.4.22.1-RXN molecular_function owl:Class
GO:0031720 biolink:NamedThing haptoglobin binding Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex. got7fsn_ti molecular_function owl:Class
GO:0080030 biolink:NamedThing methyl indole-3-acetate esterase activity Catalysis of the reaction: methyl indole-3-acetate + H2O = indole-3-acetate + methanol + H+. got7fsn_ti indole-3-Acetic acid methyl ester esterase activity|MeIAA esterase activity|methyl indole-3-acetate esterase activity|Methyl IAA esterase activity EC:3.1.1.1|MetaCyc:RXN-10711 molecular_function owl:Class
GO:0047479 biolink:NamedThing trypanothione synthase activity Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate. got7fsn_ti TSR synthetase activity|glutathionylspermidine:glutathione ligase (ADP-forming) MetaCyc:6.3.1.9-RXN|EC:6.3.1.9|RHEA:21532 molecular_function owl:Class
GO:0070581 biolink:NamedThing rolling circle DNA replication A DNA-dependent DNA replication process in which a single-stranded DNA molecule is synthesized from a circular duplex template. Replication typically does not cease when one circumference has been replicated, but continues around the circumference several more times, producing a long single strand comprising multimers of the replicon. got7fsn_ti rolling circle replication mah 2009-04-22T02:53:52Z biological_process owl:Class
GO:0006261 biolink:NamedThing DNA-dependent DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. got7fsn_ti GO:0006262|GO:0006263 biological_process owl:Class
GO:0030599 biolink:NamedThing pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate. got7fsn_ti pectin pectylhydrolase activity|pectase activity|pectin methoxylase activity|pectin demethoxylase activity|pectin methylesterase activity|pectinoesterase activity|pectin methyl esterase activity MetaCyc:PECTINESTERASE-RXN|RHEA:22380|EC:3.1.1.11 molecular_function owl:Class
GO:0042668 biolink:NamedThing auditory receptor cell fate determination The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti auditory hair cell fate determination biological_process owl:Class
GO:1901566 biolink:NamedThing organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of organonitrogen compound. got7fsn_ti organonitrogen compound biosynthesis|organonitrogen compound synthesis|organonitrogen compound formation|organonitrogen compound anabolism pr 2012-11-04T15:18:00Z biological_process owl:Class
GO:0080148 biolink:NamedThing negative regulation of response to water deprivation Any process that stops, prevents, or reduces the frequency, rate or extent of a response to water deprivation. Response to water deprivation is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. got7fsn_ti dhl 2010-03-26T01:58:11Z biological_process owl:Class
GO:0047998 biolink:NamedThing hyoscyamine (6S)-dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + L-hyoscyamine + O(2) = (6S)-6-hydroxyhyoscyamine + CO(2) + succinate. got7fsn_ti hyoscyamine 6-beta-hydroxylase activity|hyoscyamine (6S)-hydroxylase activity|hyoscyamine 6-hydroxylase activity|hyoscyamine 6beta-hydroxylase activity|L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase ((6S)-hydroxylating)|hyoscyamine 6beta-dioxygenase activity MetaCyc:HYOSCYAMINE-6-DIOXYGENASE-RXN|RHEA:12629|EC:1.14.11.11|KEGG_REACTION:R03812 molecular_function owl:Class
GO:0036466 biolink:NamedThing synaptic vesicle recycling via endosome Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate. got7fsn_ti recycling endosome localization within postsynapse bf 2014-06-26T11:07:46Z GO:0099090 biological_process owl:Class
GO:0036465 biolink:NamedThing synaptic vesicle recycling The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane. got7fsn_ti kiss-and-stay synaptic vesicle recycling|kiss-and-run synaptic vesicle recycling bf 2014-06-26T11:03:08Z biological_process owl:Class
GO:0006473 biolink:NamedThing protein acetylation The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti protein amino acid acetylation biological_process owl:Class
GO:0008387 biolink:NamedThing steroid 7-alpha-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O. got7fsn_ti cytochrome P450 CYP2A12 molecular_function owl:Class
GO:0021674 biolink:NamedThing rhombomere 8 morphogenesis The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0021593 biolink:NamedThing rhombomere morphogenesis The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. got7fsn_ti biological_process owl:Class
GO:0014812 biolink:NamedThing muscle cell migration The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism. got7fsn_ti biological_process owl:Class
GO:0003009 biolink:NamedThing skeletal muscle contraction A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control. got7fsn_ti biological_process owl:Class
GO:0006941 biolink:NamedThing striated muscle contraction A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope. got7fsn_ti sarcomeric muscle contraction biological_process owl:Class
GO:0008091 biolink:NamedThing spectrin Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins. got7fsn_ti NIF_Subcellular:sao536287099|Wikipedia:Spectrin cellular_component owl:Class
GO:0060523 biolink:NamedThing prostate epithelial cord elongation The developmental growth process in which solid chords of prostate epithelium increase in length. got7fsn_ti biological_process owl:Class
GO:2001136 biolink:NamedThing negative regulation of endocytic recycling Any process that stops, prevents or reduces the frequency, rate or extent of endocytic recycling. got7fsn_ti negative regulation of retrograde transport of endocytic vesicles kmv 2011-10-14T03:34:43Z biological_process owl:Class
GO:0042710 biolink:NamedThing biofilm formation A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. got7fsn_ti https://github.com/geneontology/go-ontology/issues/17727 biological_process owl:Class
GO:0106217 biolink:NamedThing tRNA C3-cytosine methylation The process whereby a cytosine in a tRNA is methylated at position 3 of the cytosine. got7fsn_ti hjd 2019-07-19T19:52:40Z biological_process owl:Class
GO:0036038 biolink:NamedThing MKS complex A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane. got7fsn_ti tectonic complex|MKS module|B9 complex|TCTN-B9D complex|tectonic-like complex Although there is some evidence, it is still unclear if the MKS and NPHP complexes are constituents parts of the Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the membrane and axoneme. bf 2011-11-22T11:21:28Z cellular_component owl:Class
GO:0060303 biolink:NamedThing regulation of nucleosome density Any process that modulates the number of nucleosomes in a given region of a chromosome. got7fsn_ti biological_process owl:Class
GO:0048859 biolink:NamedThing formation of anatomical boundary The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. got7fsn_ti biological_process owl:Class
GO:0048442 biolink:NamedThing sepal development The process whose specific outcome is the progression of the sepal over time, from its formation to the mature structure. got7fsn_ti GO:0048421 biological_process owl:Class
GO:0048437 biolink:NamedThing floral organ development The process whose specific outcome is the progression of the floral organ over time, from its formation to the mature structure. got7fsn_ti GO:0048433 biological_process owl:Class
GO:0018175 biolink:NamedThing protein nucleotidylation The addition of a nucleotide to a protein amino acid. got7fsn_ti protein amino acid nucleotidylation biological_process owl:Class
GO:0047506 biolink:NamedThing (deoxy)adenylate kinase activity Catalysis of the reaction: ATP + dAMP = ADP + dADP. got7fsn_ti ATP:(d)AMP phosphotransferase activity RHEA:23100|MetaCyc:DEOXYADENYLATE-KINASE-RXN|EC:2.7.4.11 molecular_function owl:Class
GO:0044094 biolink:NamedThing host cell nuclear part Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. jl 2009-04-22T01:59:14Z cellular_component owl:Class
GO:0033646 biolink:NamedThing host intracellular part Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti host cell intracellular part Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class
GO:0044554 biolink:NamedThing modulation of heart rate in other organism Any process that modulates the frequency or rate of heart contraction of another organism. got7fsn_ti regulation of heart rate in other organism jl 2012-03-29T02:59:43Z biological_process owl:Class
GO:0002027 biolink:NamedThing regulation of heart rate Any process that modulates the frequency or rate of heart contraction. got7fsn_ti cardiac chronotropy|regulation of rate of heart contraction|regulation of heart contraction rate biological_process owl:Class
GO:0071333 biolink:NamedThing cellular response to glucose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. got7fsn_ti mah 2009-12-10T05:38:03Z biological_process owl:Class
GO:0001678 biolink:NamedThing cellular glucose homeostasis A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment. got7fsn_ti cell glucose homeostasis biological_process owl:Class
GO:0044267 biolink:NamedThing cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification. got7fsn_ti cellular protein metabolism biological_process owl:Class
GO:0030152 biolink:NamedThing bacteriocin biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. got7fsn_ti bacteriocin formation|bacteriocin biosynthesis|bacteriocin synthesis|bacteriocin anabolism biological_process owl:Class
GO:0009403 biolink:NamedThing toxin biosynthetic process The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. got7fsn_ti toxin anabolism|toxin synthesis|toxin biosynthesis|toxin formation biological_process owl:Class
GO:0016418 biolink:NamedThing S-acetyltransferase activity Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule. got7fsn_ti EC:2.3.1.38 molecular_function owl:Class
GO:0004371 biolink:NamedThing glycerone kinase activity Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+). got7fsn_ti acetol kinase (phosphorylating)|ATP:glycerone phosphotransferase activity|dihydroxyacetone kinase activity|acetol kinase activity RHEA:15773|KEGG_REACTION:R01011|EC:2.7.1.29|MetaCyc:GLYCERONE-KINASE-RXN molecular_function owl:Class
GO:0019226 biolink:NamedThing transmission of nerve impulse The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. got7fsn_ti conduction of nerve impulse|signal transmission along a neuron biological_process owl:Class
GO:0062121 biolink:NamedThing linear element maturation The meiotic cell cycle chromosome organization process in which LinE complexes closely associate with chromatin during meiotic prophase to form mature linear elements. got7fsn_ti LinE chromosome loading|LinE focus formation dph 2019-03-19T14:19:27Z biological_process owl:Class
GO:0070192 biolink:NamedThing chromosome organization involved in meiotic cell cycle A process of chromosome organization that is involved in a meiotic cell cycle. got7fsn_ti chromosome organisation involved in meiosis|meiotic chromosome organization biological_process owl:Class
GO:1990409 biolink:NamedThing adrenomedullin binding Binding to adrenomedullin (AM). got7fsn_ti AM binding An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. bhm 2014-07-02T14:37:19Z molecular_function owl:Class
GO:0097644 biolink:NamedThing calcitonin family binding Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)). got7fsn_ti pr 2014-09-08T20:50:52Z molecular_function owl:Class
GO:0097387 biolink:NamedThing capitate projection Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies). got7fsn_ti pr 2012-10-22T13:57:10Z cellular_component owl:Class
GO:0097386 biolink:NamedThing glial cell projection A prolongation or process extending from a glial cell. got7fsn_ti glial process|glial projection pr 2012-10-22T13:55:54Z cellular_component owl:Class
GO:0051231 biolink:NamedThing spindle elongation The cell cycle process in which the distance is lengthened between poles of the spindle. got7fsn_ti biological_process owl:Class
GO:0007017 biolink:NamedThing microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. got7fsn_ti biological_process owl:Class
GO:0050058 biolink:NamedThing linoleate isomerase activity Catalysis of the reaction: linoleate = 9-cis,11-trans-octadecadienoate. got7fsn_ti linoleic acid isomerase activity|linoleate delta12-cis-delta11-trans-isomerase activity EC:5.2.1.5|KEGG_REACTION:R03627|MetaCyc:LINOLEATE-ISOMERASE-RXN|RHEA:17381 molecular_function owl:Class
GO:0016859 biolink:NamedThing cis-trans isomerase activity Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. got7fsn_ti EC:5.2.-.- molecular_function owl:Class
GO:0047930 biolink:NamedThing glucosaminate ammonia-lyase activity Catalysis of the reaction: D-glucosaminate = 2-dehydro-3-deoxy-D-gluconate + NH3. got7fsn_ti glucosaminic dehydrase activity|2-amino-2-deoxy-D-gluconate ammonia-lyase activity|D-glucosaminate ammonia-lyase activity|D-glucosaminate ammonia-lyase (isomerizing; 2-dehydro-3-deoxy-D-gluconate-forming)|acetylenemonocarboxylic acid hydrase activity|aminodeoxygluconate ammonia-lyase activity|aminodeoxygluconate dehydratase activity|2-amino-2-deoxy-D-gluconate hydro-lyase (deaminating) activity|D-glucosaminic acid dehydrase activity|D-glucosaminate dehydratase activity Note that this function was EC:4.3.1.21. GO:0050443 EC:4.3.1.9|RHEA:12488|MetaCyc:4.3.1.21-RXN molecular_function owl:Class
GO:0016841 biolink:NamedThing ammonia-lyase activity Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. got7fsn_ti EC:4.3.1.- molecular_function owl:Class
GO:0035119 biolink:NamedThing embryonic pelvic fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. got7fsn_ti biological_process owl:Class
GO:0035113 biolink:NamedThing embryonic appendage morphogenesis The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. got7fsn_ti biological_process owl:Class
GO:0060520 biolink:NamedThing activation of prostate induction by androgen receptor signaling pathway Any series of molecular signals generated as a consequence of an androgen binding to its receptor in the urogenital sinus mesenchyme that initiates prostate induction. Prostate induction is the close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland. got7fsn_ti activation of prostate induction by androgen receptor signalling pathway biological_process owl:Class
GO:0030521 biolink:NamedThing androgen receptor signaling pathway Any series of molecular signals generated as a consequence of an androgen binding to its receptor. got7fsn_ti androgen receptor signalling pathway biological_process owl:Class
GO:0050298 biolink:NamedThing stizolobinate synthase activity Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. got7fsn_ti 3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing) RHEA:18465|MetaCyc:STIZOLOBINATE-SYNTHASE-RXN|EC:1.13.11.30 molecular_function owl:Class
GO:0004496 biolink:NamedThing mevalonate kinase activity Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+). got7fsn_ti mevalonate 5-phosphotransferase activity|MVA kinase activity|ATP:(R)-mevalonate 5-phosphotransferase activity|mevalonate kinase (phosphorylating)|mevalonate phosphokinase activity|mevalonic kinase activity|ATP:mevalonate 5-phosphotransferase activity|mevalonic acid kinase activity KEGG_REACTION:R02245|EC:2.7.1.36|Reactome:R-HSA-191380|MetaCyc:MEVALONATE-KINASE-RXN|RHEA:17065 molecular_function owl:Class
GO:0043964 biolink:NamedThing induction by symbiont of host adenylate cyclase-mediated signal transduction Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host adenylate cyclase-mediated signal transduction biological_process owl:Class
GO:0031034 biolink:NamedThing myosin filament assembly The aggregation, arrangement and bonding together of a filament composed of myosin molecules. got7fsn_ti myosin polymerization biological_process owl:Class
GO:0007035 biolink:NamedThing vacuolar acidification Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. got7fsn_ti biological_process owl:Class
GO:0051452 biolink:NamedThing intracellular pH reduction Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion. got7fsn_ti reduction of pH in cell|cellular acidification|cell pH reduction|intracellular acidification|reduction of cellular pH biological_process owl:Class
GO:0002212 biolink:NamedThing behavioral defense response to nematode A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism. got7fsn_ti behavioural defense response to nematode biological_process owl:Class
GO:0002215 biolink:NamedThing defense response to nematode A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. got7fsn_ti physiological defense response to nematode GO:0002216 biological_process owl:Class
GO:0048036 biolink:NamedThing central complex development The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli. got7fsn_ti central body development biological_process owl:Class
GO:0002317 biolink:NamedThing plasma cell differentiation The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. got7fsn_ti plasma cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0002313 biolink:NamedThing mature B cell differentiation involved in immune response The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response. got7fsn_ti mature B cell development involved in immune response|mature B lymphocyte differentiation during immune response|mature B cell differentiation during immune response|mature B-lymphocyte differentiation during immune response|mature B-cell differentiation during immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0046365 biolink:NamedThing monosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. got7fsn_ti monosaccharide degradation|monosaccharide catabolism|monosaccharide breakdown biological_process owl:Class
GO:0035045 biolink:NamedThing sperm plasma membrane disassembly The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg. got7fsn_ti sperm plasma membrane catabolism|sperm plasma membrane breakdown|sperm plasma membrane degradation biological_process owl:Class
GO:0150155 biolink:NamedThing interleukin-34 production The appearance of interleukin-34 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti bc 2020-01-06T16:25:25Z biological_process owl:Class
GO:0004909 biolink:NamedThing interleukin-1, type I, activating receptor activity Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins. got7fsn_ti interleukin-1 type I receptor activity|interleukin-1, type I, activating binding|interleukin-1 activating receptor activity|IL-1 type I, activating receptor|IL-1 type I, activating binding GO:0019967 molecular_function owl:Class
GO:0004908 biolink:NamedThing interleukin-1 receptor activity Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. got7fsn_ti IL-1 receptor activity|IL-1R Wikipedia:Interleukin-1_receptor molecular_function owl:Class
GO:0051291 biolink:NamedThing protein heterooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. got7fsn_ti protein heterooligomer biosynthesis|protein heterooligomer formation|protein heterooligomer assembly|protein heterooligomer biosynthetic process biological_process owl:Class
GO:0071350 biolink:NamedThing cellular response to interleukin-15 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus. got7fsn_ti cellular response to IL-15 mah 2009-12-11T02:49:51Z biological_process owl:Class
GO:0070672 biolink:NamedThing response to interleukin-15 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-15 stimulus. got7fsn_ti response to IL-15 mah 2009-05-29T10:03:09Z biological_process owl:Class
GO:0015620 biolink:NamedThing ferric-enterobactin transmembrane transporter activity Enables the transfer of ferric-enterobactin from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0071340 biolink:NamedThing skeletal muscle acetylcholine-gated channel clustering The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals. got7fsn_ti skeletal muscle nicotinic acetylcholine receptor clustering|skeletal muscle AChR clustering mah 2009-12-11T11:13:55Z biological_process owl:Class
GO:0015566 biolink:NamedThing acriflavine transmembrane transporter activity Enables the directed movement of acriflavin from one side of a membrane to the other. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. got7fsn_ti acriflavine transporter activity|acriflavin transporter activity|acriflavin resistant pump activity GO:0015555 molecular_function owl:Class
GO:0002452 biolink:NamedThing B cell receptor editing The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor. got7fsn_ti B-lymphocyte receptor editing|B lymphocyte receptor editing|B-cell receptor editing biological_process owl:Class
GO:0016447 biolink:NamedThing somatic recombination of immunoglobulin gene segments The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. got7fsn_ti somatic recombination of antibody gene segments biological_process owl:Class
GO:0043379 biolink:NamedThing memory T cell differentiation The process in which a newly activated T cell acquires specialized features of a memory T cell. got7fsn_ti memory T cell development|memory T-lymphocyte differentiation|memory T-cell differentiation|memory T lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0090715 biolink:NamedThing immunological memory formation process Any immunological memory process that can contribute to the formation of immunological memory. got7fsn_ti tb 2016-11-11T12:25:47Z biological_process owl:Class
GO:0042022 biolink:NamedThing interleukin-12 receptor complex A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. got7fsn_ti IL12RB1-IL12RB2 complex|IL-12 receptor complex cellular_component owl:Class
GO:0010460 biolink:NamedThing positive regulation of heart rate Any process that activates or increases the frequency or rate of heart contraction. got7fsn_ti biological_process owl:Class
GO:0045823 biolink:NamedThing positive regulation of heart contraction Any process that activates or increases the frequency, rate or extent of heart contraction. got7fsn_ti up-regulation of heart contraction|upregulation of heart contraction|positive regulation of cardiac contraction|up regulation of heart contraction|activation of heart contraction|stimulation of heart contraction biological_process owl:Class
GO:0015562 biolink:NamedThing efflux transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti efflux permease activity|monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity molecular_function owl:Class
GO:0022857 biolink:NamedThing transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. got7fsn_ti substrate-specific transmembrane transporter activity|substrate-specific transporter activity|uptake transmembrane transporter activity|uptake permease activity GO:0015646|GO:0005386|GO:0022892|GO:0015563|GO:0022891 Reactome:R-HSA-6784436|Reactome:R-HSA-5671707|Reactome:R-HSA-429036|Reactome:R-HSA-6784434|Reactome:R-HSA-5638209|Reactome:R-HSA-1236947 molecular_function owl:Class
GO:0018061 biolink:NamedThing peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid. got7fsn_ti peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine|peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine|peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine RESID:AA0128 biological_process owl:Class
GO:0045993 biolink:NamedThing negative regulation of translational initiation by iron Any process involving iron that stops, prevents or reduces the rate of translational initiation. got7fsn_ti downregulation of translational initiation by iron|down regulation of translational initiation by iron|inhibition of translational initiation by iron|down-regulation of translational initiation by iron biological_process owl:Class
GO:0006447 biolink:NamedThing regulation of translational initiation by iron Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron. got7fsn_ti biological_process owl:Class
GO:0050563 biolink:NamedThing trans-feruloyl-CoA synthase activity Catalysis of the reaction: ATP + CoA + trans-ferulate = (E)-feruloyl-CoA + ADP + phosphate. got7fsn_ti trans-feruloyl-CoA synthetase activity|trans-ferulate:CoASH ligase (ATP-hydrolysing)|ferulate-CoA ligase activity hjd 2020-07-30T15:20:51Z GO:0106287 MetaCyc:6.2.1.34-RXN|RHEA:19389|EC:6.2.1.34 molecular_function owl:Class
GO:0005105 biolink:NamedThing type 1 fibroblast growth factor receptor binding Binding to a type 1 fibroblast growth factor receptor (FGFR1). got7fsn_ti FGFR1 ligand|breathless ligand|type 1 fibroblast growth factor receptor ligand|FGFR1 binding|breathless binding Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1). molecular_function owl:Class
GO:0005104 biolink:NamedThing fibroblast growth factor receptor binding Binding to a fibroblast growth factor receptor (FGFR). got7fsn_ti FGFR binding|fibroblast growth factor receptor ligand|FGFR ligand|fibroblast growth factor|FGF receptor binding Note that branchless is the Drosophila gene encoding fibroblast growth factor. GO:0005162|GO:0001521 molecular_function owl:Class
GO:0097538 biolink:NamedThing ciliary necklace A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links. got7fsn_ti cilial necklace|cilium necklace pr 2013-12-03T16:43:41Z cellular_component owl:Class
GO:0050069 biolink:NamedThing lysine dehydrogenase activity Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH. got7fsn_ti L-lysine:NAD+ oxidoreductase (deaminating, cyclizing) EC:1.4.1.15|MetaCyc:LYSINE-DEHYDROGENASE-RXN|RHEA:18505 molecular_function owl:Class
GO:0044634 biolink:NamedThing negative regulation of complement activation, alternative pathway in other organism Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism. got7fsn_ti jl 2012-07-05T04:32:55Z biological_process owl:Class
GO:0044633 biolink:NamedThing modulation of complement activation, alternative pathway in other organism A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism. got7fsn_ti regulation of complement activation, alternative pathway in other organism jl 2012-07-05T04:24:08Z biological_process owl:Class
GO:1990953 biolink:NamedThing intramanchette transport The movement of vesicles and protein complexes carried out by molecular motors, kinesins and dynein, along the microtubule tracks within the manchette and by myosin along actin filaments. got7fsn_ti IMT krc 2016-05-11T00:17:56Z biological_process owl:Class
GO:0098840 biolink:NamedThing protein transport along microtubule The directed movement of a protein along a microtubule, mediated by motor proteins. got7fsn_ti microtubule-based protein transport biological_process owl:Class
GO:0102305 biolink:NamedThing (13E)-labda-7,13-dien-15-ol synthase activity Catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid. got7fsn_ti MetaCyc:RXN-12892|EC:3.1.7.10|RHEA:32075 molecular_function owl:Class
GO:0016794 biolink:NamedThing diphosphoric monoester hydrolase activity Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group. got7fsn_ti EC:3.1.7.- molecular_function owl:Class
GO:2000146 biolink:NamedThing negative regulation of cell motility Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility. got7fsn_ti negative regulation of cell movement|negative regulation of cell locomotion|negative regulation of movement of a cell mah 2010-10-01T09:41:26Z biological_process owl:Class
GO:0048851 biolink:NamedThing hypophysis formation The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands. got7fsn_ti pituitary gland biosynthesis|hypophysis biosynthesis|pituitary gland formation biological_process owl:Class
GO:0021725 biolink:NamedThing superior raphe nucleus development The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure. got7fsn_ti anterior raphe nucleus development|superior central nucleus development biological_process owl:Class
GO:0019150 biolink:NamedThing D-ribulokinase activity Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate. got7fsn_ti ATP:D-ribulose 5-phosphotransferase activity|D-ribulokinase (phosphorylating) MetaCyc:D-RIBULOKIN-RXN|RHEA:17601|EC:2.7.1.47 molecular_function owl:Class
GO:0031349 biolink:NamedThing positive regulation of defense response Any process that activates or increases the frequency, rate or extent of a defense response. got7fsn_ti up regulation of defense response|upregulation of defense response|activation of defense response|up-regulation of defense response|stimulation of defense response biological_process owl:Class
GO:0031347 biolink:NamedThing regulation of defense response Any process that modulates the frequency, rate or extent of a defense response. got7fsn_ti biological_process owl:Class
GO:0021741 biolink:NamedThing spinal trigeminal nucleus development The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0021730 biolink:NamedThing trigeminal sensory nucleus development The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure. got7fsn_ti Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord. biological_process owl:Class
GO:0008083 biolink:NamedThing growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. got7fsn_ti Also consider annotating to 'receptor agonist activity ; GO:0048018'. molecular_function owl:Class
GO:0048018 biolink:NamedThing receptor ligand activity The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands). got7fsn_ti signaling receptor ligand activity|receptor agonist activity|signaling molecule|vitamin D receptor activator activity https://github.com/geneontology/go-ontology/issues/14220 mah 2010-09-13T04:51:59Z GO:0071884 molecular_function owl:Class
GO:0020014 biolink:NamedThing schizogony Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously. got7fsn_ti Wikipedia:Protozoal_merogony biological_process owl:Class
GO:0090426 biolink:NamedThing actin filament bundle convergence A process of actin filament bundle distribution that results in the compaction of actin filaments. got7fsn_ti tb 2012-05-04T09:33:09Z biological_process owl:Class
GO:0070650 biolink:NamedThing actin filament bundle distribution Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell. got7fsn_ti mah 2009-05-12T02:20:58Z biological_process owl:Class
GO:0046952 biolink:NamedThing ketone body catabolic process The chemical reactions and pathways resulting in the breakdown of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Ketone bodies can be used as an energy source as an alternative to glucose. Utilization of ketone bodies in peripheral tissues involves conversion of acetoacetate to acetoacetyl-CoA, which is then converted to two molecules of acetyl-CoA. got7fsn_ti ketone body breakdown|ketone body catabolism|utilization of ketone bodies|ketone body degradation|ketolysis MetaCyc:PWY66-368|Reactome:R-HSA-77108 biological_process owl:Class
GO:0046950 biolink:NamedThing cellular ketone body metabolic process The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism. got7fsn_ti cellular ketone body metabolism biological_process owl:Class
GO:1990375 biolink:NamedThing baculum development The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure. got7fsn_ti os penis development|penis bone development|penile bone development sl 2014-05-01T23:59:13Z biological_process owl:Class
GO:0072578 biolink:NamedThing neurotransmitter-gated ion channel clustering The receptor clustering process in which neurotransmitter-gated ion channels are localized to distinct domains in the cell membrane. got7fsn_ti mah 2011-02-03T01:45:48Z biological_process owl:Class
GO:0150050 biolink:NamedThing postsynaptic septin cytoskeleton The portion of the septin cytoskeleton contained within the postsynapse. got7fsn_ti bc 2018-04-26T14:45:52Z cellular_component owl:Class
GO:0004727 biolink:NamedThing prenylated protein tyrosine phosphatase activity Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate. got7fsn_ti molecular_function owl:Class
GO:0004725 biolink:NamedThing protein tyrosine phosphatase activity Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. got7fsn_ti PTP-phosphatase activity|protein-tyrosine-phosphatase activity|phosphotyrosine histone phosphatase activity|phosphoprotein phosphatase (phosphotyrosine) activity|PPT-phosphatase activity|PTPase activity|[phosphotyrosine]protein phosphatase activity|protein phosphotyrosine phosphatase activity|protein-tyrosine-phosphate phosphohydrolase activity|tyrosylprotein phosphatase activity|tyrosine O-phosphate phosphatase activity|phosphotyrosine phosphatase activity|phosphotyrosine protein phosphatase activity|phosphotyrosylprotein phosphatase activity MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN|Reactome:R-HSA-1549564|Reactome:R-HSA-8863804|Reactome:R-HSA-203797|Reactome:R-HSA-202214|Reactome:R-HSA-8852200|Reactome:R-HSA-377643|Reactome:R-HSA-914036|Reactome:R-HSA-877308|Reactome:R-HSA-445089|Reactome:R-HSA-8849435|Reactome:R-HSA-1169210|Reactome:R-HSA-6807008|Reactome:R-HSA-8864125|Reactome:R-HSA-8864029|Reactome:R-HSA-391868|RHEA:10684|Reactome:R-HSA-1169192|Reactome:R-HSA-8937767|Reactome:R-HSA-8855381|Reactome:R-HSA-1169188|Reactome:R-HSA-74733|Reactome:R-HSA-74748|Reactome:R-HSA-9635461|EC:3.1.3.48|Reactome:R-HSA-389758|Reactome:R-HSA-997311|Reactome:R-HSA-8867047|Reactome:R-HSA-74747|Reactome:R-HSA-9636439|Reactome:R-HSA-8864036|Reactome:R-HSA-8867658|Reactome:R-HSA-9603719|Reactome:R-HSA-997326|Reactome:R-HSA-9698408|Reactome:R-HSA-6807027|Reactome:R-HSA-5683967|Reactome:R-HSA-997314|Reactome:R-HSA-997309 molecular_function owl:Class
GO:0061519 biolink:NamedThing macrophage homeostasis The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti dph 2013-04-18T13:25:33Z biological_process owl:Class
GO:0005955 biolink:NamedThing calcineurin complex A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. got7fsn_ti protein phosphatase type 2B complex|calcium-dependent protein serine/threonine phosphatase complex cellular_component owl:Class
GO:0033844 biolink:NamedThing galactose-6-sulfurylase activity Catalysis of the elimination of sulfate from the D-galactose 6-sulfate residues of porphyran, producing 3,6-anhydrogalactose residues. got7fsn_ti galactose-6-sulfatase activity|D-galactose-6-sulfate:alkyltransferase (cyclizing) activity|galactose 6-sulfatase activity|porphyran sulfatase activity MetaCyc:2.5.1.5-RXN|EC:2.5.1.5 molecular_function owl:Class
GO:0039630 biolink:NamedThing RNA translocase activity Generating a movement along a single- or double-stranded RNA molecule, driven by ATP hydrolysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21612 Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. bf 2012-08-06T13:24:51Z molecular_function owl:Class
GO:0008186 biolink:NamedThing ATP-dependent activity, acting on RNA Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. got7fsn_ti ATPase activity, acting on RNA|RNA-dependent ATPase activity|RNA-dependent adenosinetriphosphatase activity|ATPase, acting on RNA https://github.com/geneontology/go-ontology/issues/20876|https://github.com/geneontology/go-ontology/issues/21775 GO:0004010 molecular_function owl:Class
GO:0014887 biolink:NamedThing cardiac muscle adaptation The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. got7fsn_ti cardiac muscle plasticity biological_process owl:Class
GO:0014888 biolink:NamedThing striated muscle adaptation Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities. got7fsn_ti striated muscle plasticity biological_process owl:Class
GO:0051818 biolink:NamedThing disruption of cells of other organism involved in symbiotic interaction A process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction. got7fsn_ti disruption of cells of other organism during symbiotic interaction biological_process owl:Class
GO:0010361 biolink:NamedThing regulation of anion channel activity by blue light Any process in which blue light modulates the frequency, rate or extent of anion channel activity. got7fsn_ti regulation by blue light of anion channel activity biological_process owl:Class
GO:0010359 biolink:NamedThing regulation of anion channel activity Any process that modulates the frequency, rate or extent of anion channel activity. got7fsn_ti biological_process owl:Class
GO:0033024 biolink:NamedThing mast cell apoptotic process Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. got7fsn_ti apoptosis of mast cells|mast cell apoptosis biological_process owl:Class
GO:0033028 biolink:NamedThing myeloid cell apoptotic process Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage. got7fsn_ti apoptosis of myeloid cells|myeloid cell apoptosis biological_process owl:Class
GO:0102179 biolink:NamedThing 24-ethylidenelophenol 4alpha-methyl oxidase activity Catalysis of the reaction: 24-ethylidenelophenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O. got7fsn_ti MetaCyc:RXN-11935|RHEA:59032 molecular_function owl:Class
GO:0106222 biolink:NamedThing long noncoding RNA binding Binding to a long noncoding RNA (lncRNA). got7fsn_ti lncRNA binding hjd 2019-08-27T14:52:58Z molecular_function owl:Class
GO:0019959 biolink:NamedThing interleukin-8 binding Binding to interleukin-8. got7fsn_ti IL-8 binding molecular_function owl:Class
GO:0019958 biolink:NamedThing C-X-C chemokine binding Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. got7fsn_ti molecular_function owl:Class
GO:0046962 biolink:NamedThing sodium-transporting ATPase activity, rotational mechanism Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out), by a rotational mechanism. got7fsn_ti sodium transporting ATPase activity, rotational mechanism|ATP phosphohydrolase (Na+-transporting) activity|Na(+)-translocating ATPase activity|Na(+)-transporting two-sector ATPase activity|sodium-translocating F-type ATPase activity|vacuolar-type Na+-translocating ATPase|ATP synthase, sodium ion specific activity|vacuolar-type Na+-ATPase|Na+-translocating ATPase activity|sodium-transporting two-sector ATPase activity|sodium-translocating V-type ATPase activity|Na+-translocating F1Fo-ATPase|Na+-transporting two-sector ATPase https://github.com/geneontology/go-ontology/issues/21796 Found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis; similar to EC:7.1.2.2 but pumps Na(+) rather than H(+). (Source: EC:7.2.2.1) RHEA:58157|RHEA:58156|EC:7.2.2.1|MetaCyc:3.6.3.15-RXN molecular_function owl:Class
GO:0044769 biolink:NamedThing ATPase activity, coupled to transmembrane movement of ions, rotational mechanism Enables the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism. got7fsn_ti jl 2013-02-20T13:41:38Z molecular_function owl:Class
GO:0102920 biolink:NamedThing acyl coenzyme A: isopenicillin N acyltransferase activity Catalysis of the reaction: octanoyl-CoA + isopenicillin N + H2O <=> H+ + coenzyme A + penicillin K + L-2-aminoadipate. got7fsn_ti EC:2.3.1.164|MetaCyc:RXN-8809 molecular_function owl:Class
GO:0015031 biolink:NamedThing protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti enzyme transport GO:0015831 biological_process owl:Class
GO:1990134 biolink:NamedThing epithelial cell apoptotic process involved in palatal shelf morphogenesis An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf. got7fsn_ti dph 2013-06-26T11:56:00Z biological_process owl:Class
GO:0060561 biolink:NamedThing apoptotic process involved in morphogenesis Any apoptotic process that contributes to the shaping of an anatomical structure. got7fsn_ti apoptosis involved in morphogenesis|apoptosis involved in development|morphogenetic apoptosis dph 2009-04-28T09:17:27Z biological_process owl:Class
GO:0006936 biolink:NamedThing muscle contraction A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. got7fsn_ti Wikipedia:Muscle_contraction biological_process owl:Class
GO:1990215 biolink:NamedThing negative regulation by symbiont of host intracellular transport Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of intracellular transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-10T15:42:22Z biological_process owl:Class
GO:0052038 biolink:NamedThing modulation by symbiont of host intracellular transport Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation of host intracellular trafficking biological_process owl:Class
GO:0035606 biolink:NamedThing peptidyl-cysteine S-trans-nitrosylation Transfer of a nitric oxide (NO) group from one cysteine residue to another. got7fsn_ti cysteine to cysteine nitrosylation|S-transnitrosylation|cysteine-to-cysteine transnitrosylation|protein-to-protein transnitrosylation bf 2010-11-16T09:54:46Z biological_process owl:Class
GO:0018119 biolink:NamedThing peptidyl-cysteine S-nitrosylation The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine. got7fsn_ti S-nitrosylation|protein S-nitrosylation RESID:AA0230 biological_process owl:Class
GO:0043744 biolink:NamedThing N2-acetyl-L-aminoadipate kinase activity Catalysis of the reaction: ATP + N-acetyl-L-2-aminoadipate = ADP + N-acetyl-L-2-aminoadipate 6-phosphate. got7fsn_ti [LysW]-aminoadipate kinase|acetylaminoadipate kinase activity|N-acetylaminoadipate kinase activity|N-acetyl-L-aminoadipate 5-phosphotransferase activity GO:0043868 RHEA:41944|MetaCyc:RXN-5182 molecular_function owl:Class
GO:0016774 biolink:NamedThing phosphotransferase activity, carboxyl group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). got7fsn_ti EC:2.7.2.- molecular_function owl:Class
GO:0017198 biolink:NamedThing N-terminal peptidyl-serine acetylation The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine. got7fsn_ti RESID:AA0051 biological_process owl:Class
GO:0019970 biolink:NamedThing interleukin-11 binding Binding to interleukin-11. got7fsn_ti IL-11 binding molecular_function owl:Class
GO:0009978 biolink:NamedThing allene oxide synthase activity Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O. got7fsn_ti linoleate hydroperoxide isomerase|HPI|(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]|linoleic acid hydroperoxide isomerase RHEA:25074|MetaCyc:RXN1F-19 molecular_function owl:Class
GO:0045199 biolink:NamedThing maintenance of epithelial cell apical/basal polarity The maintenance of the apicobasal polarity of an epithelial cell. got7fsn_ti biological_process owl:Class
GO:0035090 biolink:NamedThing maintenance of apical/basal cell polarity Retaining the established polarization of a cell along its apical/basal axis. got7fsn_ti biological_process owl:Class
GO:0039011 biolink:NamedThing pronephric proximal tubule morphogenesis The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. got7fsn_ti pronephros proximal tubule morphogenesis bf 2010-07-02T09:53:12Z biological_process owl:Class
GO:0072158 biolink:NamedThing proximal tubule morphogenesis The process in which the anatomical structures of a proximal tubule are generated and organized. The proximal tubule is a nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle. It has a brush border epithelial morphology. got7fsn_ti mah 2010-02-24T02:35:36Z biological_process owl:Class
GO:0106294 biolink:NamedThing NADPH oxidase H202-forming activity Catalysis of the reaction: NADPH + H+ + O2 = NADP + hydrogen peroxide (H2O2). got7fsn_ti hjd 2020-08-19T17:38:36Z RHEA:11260 molecular_function owl:Class
GO:0016174 biolink:NamedThing NAD(P)H oxidase H2O2-forming activity Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. got7fsn_ti NAD(P)H:oxygen oxidoreductase activity|dual oxidase activity|p138tox|thyroid oxidase activity|thyroid NADPH oxidase activity|THOX2 activity|thyroid oxidase 2 activity|NAD(P)H oxidase activity|NADPH oxidase|ThOX activity EC:1.6.3.1|Reactome:R-HSA-9698758|Reactome:R-HSA-5693681 molecular_function owl:Class
GO:1990401 biolink:NamedThing embryonic lung development The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure. got7fsn_ti sl 2014-06-23T19:56:13Z biological_process owl:Class
GO:1900600 biolink:NamedThing endocrocin metabolic process The chemical reactions and pathways involving endocrocin. got7fsn_ti endocrocin metabolism di 2012-05-15T06:57:14Z biological_process owl:Class
GO:0106372 biolink:NamedThing primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC. got7fsn_ti hjd 2021-04-01T16:53:38Z molecular_function owl:Class
GO:0000752 biolink:NamedThing agglutination involved in conjugation with cellular fusion The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation with cellular fusion of a unicellular organism. An example of this process is agglutination in Saccharomyces cerevisiae. got7fsn_ti agglutination|cell-cell adhesion during mating|cell-cell adhesion during conjugation with cellular fusion GO:0007334 biological_process owl:Class
GO:0000771 biolink:NamedThing agglutination involved in conjugation The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation. got7fsn_ti biological_process owl:Class
GO:0030638 biolink:NamedThing polyketide metabolic process The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. got7fsn_ti polyketide metabolism biological_process owl:Class
GO:0106302 biolink:NamedThing arachidonic acid 8,9-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-8,9-epoxyeicosatrienoic acid. got7fsn_ti hjd 2020-08-28T19:10:07Z RHEA:64984 molecular_function owl:Class
GO:0001984 biolink:NamedThing artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure. got7fsn_ti vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure biological_process owl:Class
GO:0038160 biolink:NamedThing CXCL12-activated CXCR4 signaling pathway A series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CXCL12-activated CXCR4 signalling pathway bf 2012-05-14T01:33:17Z biological_process owl:Class
GO:0038146 biolink:NamedThing chemokine (C-X-C motif) ligand 12 signaling pathway A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CXCL12-activated CXCR7 signaling pathway|CXCL12 signaling pathway|stromal cell-derived factor-1 signaling pathway|SDF1 signaling pathway bf 2012-05-11T11:26:17Z biological_process owl:Class
GO:0030172 biolink:NamedThing troponin C binding Binding to troponin C, the calcium-binding subunit of the troponin complex. got7fsn_ti molecular_function owl:Class
GO:0034557 biolink:NamedThing 2-hydroxylaminobenzoate reductase activity Catalysis of the reaction: 2-hydroxylaminobenzoate + NAD(P)H = anthranilate + NAD(P)+ + H2O. got7fsn_ti o-hydroxylaminobenzoate nitroreductase activity UM-BBD_reactionID:r0850|MetaCyc:RXN-8848 molecular_function owl:Class
GO:0038095 biolink:NamedThing Fc-epsilon receptor signaling pathway A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. got7fsn_ti Fc-epsilon receptor signalling pathway bf 2012-02-16T05:23:51Z biological_process owl:Class
GO:0038093 biolink:NamedThing Fc receptor signaling pathway A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. got7fsn_ti Fc receptor signalling pathway bf 2012-02-16T05:11:30Z biological_process owl:Class
GO:0007536 biolink:NamedThing activation of recombination (HML) The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. got7fsn_ti biological_process owl:Class
GO:0045911 biolink:NamedThing positive regulation of DNA recombination Any process that activates or increases the frequency, rate or extent of DNA recombination. got7fsn_ti stimulation of DNA recombination|up regulation of DNA recombination|upregulation of DNA recombination|activation of DNA recombination|up-regulation of DNA recombination biological_process owl:Class
GO:0034292 biolink:NamedThing pinholin activity A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting ion channel activity indirectly allows endolysin (murein hydrolyases) to access their cell wall substrate by collapsing the proton motive force (PMF) across the membrane, allowing the endolysin to fold to an active form and hydrolyze bonds in the peptidoglycan cell wall. got7fsn_ti molecular_function owl:Class
GO:0030324 biolink:NamedThing lung development The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. got7fsn_ti biological_process owl:Class
GO:0003876 biolink:NamedThing AMP deaminase activity Catalysis of the reaction: AMP + H2O = IMP + NH3. got7fsn_ti adenosine 5-monophosphate deaminase activity|AMP aminase activity|adenylic deaminase activity|adenosine 5-phosphate aminohydrolase activity|adenylate aminohydrolase activity|adenylate desaminase activity|adenylic acid deaminase activity|adenyl deaminase activity|adenosine monophosphate deaminase activity|adenylate deaminase reaction|AMP aminohydrolase activity|adenylate deaminase activity|5-AMP deaminase activity|5-adenylate deaminase activity|5-adenylic acid deaminase activity|myoadenylate deaminase activity RHEA:14777|EC:3.5.4.6|MetaCyc:AMP-DEAMINASE-RXN|Reactome:R-HSA-76590 molecular_function owl:Class
GO:0140320 biolink:NamedThing PAMP receptor decoy activity A gene product which recognizes, binds and sequesters PAMP ligands in order to prevent them from binding and activating to the host PAMP receptor. Usually this activity is encoded by a symbiont or a pathogen to prevent activation of the host innate immune response. got7fsn_ti pattern recognition receptor decoy activity|pathogen-associated molecular pattern receptor decoy activity pg 2019-04-02T11:07:13Z molecular_function owl:Class
GO:0140319 biolink:NamedThing receptor decoy activity Recognizing, binding and sequestering a specific receptor ligand to prevent it from binding to its regular receptor. got7fsn_ti decoy receptor|decoy death receptor activity pg 2019-04-02T10:57:46Z GO:0005040 molecular_function owl:Class
GO:0072550 biolink:NamedThing triferuloylspermidine meta-hydroxylase activity Catalysis of the reaction: triferuloyl spermidine + NADPH + O2 = diferuloyl mono-(hydroxyferuloyl) spermidine + NADP+ + H2O. got7fsn_ti triferuloyl spermidine meta-hydroxylase activity mah 2011-01-25T02:58:56Z MetaCyc:RXN-11262 molecular_function owl:Class
GO:0072532 biolink:NamedThing tri-(feruloyl or hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the meta-hydroxylation of any of the three phenolic rings on triferuloyl spermidine or any of its mono- or di-(hydroxyferuloyl)-spermidine derivatives. got7fsn_ti Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-triferuloyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tri-(hydroxyferuloyl)-spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11262 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11262) and the KEGG reaction R08986 (http://www.genome.jp/dbget-bin/www_bget?rn:R08986). mah 2011-01-12T01:54:31Z molecular_function owl:Class
GO:0048565 biolink:NamedThing digestive tract development The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. got7fsn_ti intestinal development|intestine development|gut development biological_process owl:Class
GO:0008013 biolink:NamedThing beta-catenin binding Binding to a catenin beta subunit. got7fsn_ti molecular_function owl:Class
GO:0018140 biolink:NamedThing peptide cross-linking via L-cysteine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti RESID:AA0244 biological_process owl:Class
GO:0008964 biolink:NamedThing phosphoenolpyruvate carboxylase activity Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-. got7fsn_ti PEPC|phosphate:oxaloacetate carboxy-lyase (phosphorylating)|PEP carboxylase activity|phosphopyruvate (phosphate) carboxylase activity|phosphoenolpyruvic carboxylase activity|phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)|PEPCase activity KEGG_REACTION:R00345|MetaCyc:PEPCARBOX-RXN|RHEA:28370|EC:4.1.1.31 molecular_function owl:Class
GO:0004611 biolink:NamedThing phosphoenolpyruvate carboxykinase activity Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products. got7fsn_ti PEPCK activity|PEP carboxykinase activity|phosphopyruvate carboxylase activity EC:4.1.1.32 molecular_function owl:Class
GO:0061131 biolink:NamedThing pancreas field specification The process in which a specific region of the gut is delineated into the area in which the pancreas will develop. got7fsn_ti dph 2010-05-17T09:39:49Z biological_process owl:Class
GO:0010092 biolink:NamedThing specification of animal organ identity The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0015424 biolink:NamedThing ABC-type amino acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out). got7fsn_ti amino acid ABC transporter|ATPase-coupled amino acid transmembrane transporter activity|amino acid-importing ATPase activity|ATP-dependent amino acid transmembrane transporter activity|amino acid-transporting ATPase activity|amino acid-exporting ATPase activity GO:0032518|GO:0032520 molecular_function owl:Class
GO:0002522 biolink:NamedThing leukocyte migration involved in immune response The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response. got7fsn_ti leucocyte trafficking during immune response|immune cell migration during immune response|leukocyte trafficking during immune response|leucocyte migration during immune response|immune cell trafficking during immune response biological_process owl:Class
GO:0016648 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide. got7fsn_ti oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor EC:1.5.4.- molecular_function owl:Class
GO:0060952 biolink:NamedThing cardiac glial cell development The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell. got7fsn_ti dph 2009-09-29T03:09:24Z biological_process owl:Class
GO:0021782 biolink:NamedThing glial cell development The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0051447 biolink:NamedThing negative regulation of meiotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle. got7fsn_ti down regulation of progression through meiotic cell cycle|inhibition of progression through meiotic cell cycle|negative regulation of meiotic cell cycle progression|negative regulation of progression through meiotic cell cycle|downregulation of progression through meiotic cell cycle|down-regulation of progression through meiotic cell cycle biological_process owl:Class
GO:2000242 biolink:NamedThing negative regulation of reproductive process Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process. got7fsn_ti mah 2010-11-10T02:44:05Z biological_process owl:Class
GO:0061673 biolink:NamedThing mitotic spindle astral microtubule Any of the mitotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. got7fsn_ti dph 2014-12-08T18:27:20Z cellular_component owl:Class
GO:0000235 biolink:NamedThing astral microtubule Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. got7fsn_ti cellular_component owl:Class
GO:0045621 biolink:NamedThing positive regulation of lymphocyte differentiation Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation. got7fsn_ti up-regulation of lymphocyte differentiation|positive regulation of lymphocyte development|activation of lymphocyte differentiation|stimulation of lymphocyte differentiation|upregulation of lymphocyte differentiation|up regulation of lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0051251 biolink:NamedThing positive regulation of lymphocyte activation Any process that activates or increases the frequency, rate or extent of lymphocyte activation. got7fsn_ti activation of lymphocyte activation|up-regulation of lymphocyte activation|upregulation of lymphocyte activation|up regulation of lymphocyte activation|stimulation of lymphocyte activation biological_process owl:Class
GO:0001990 biolink:NamedThing regulation of systemic arterial blood pressure by hormone The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. got7fsn_ti hormonal control of blood pressure|blood pressure regulation by hormone|hormonal regulation of blood pressure biological_process owl:Class
GO:0003044 biolink:NamedThing regulation of systemic arterial blood pressure mediated by a chemical signal The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine. got7fsn_ti blood pressure regulation mediated by a chemical signal biological_process owl:Class
GO:1903043 biolink:NamedThing positive regulation of chondrocyte hypertrophy Any process that activates or increases the frequency, rate or extent of chondrocyte hypertrophy. got7fsn_ti up regulation of chondrocyte hypertrophy|upregulation of chondrocyte hypertrophy|activation of chondrocyte hypertrophy|up-regulation of chondrocyte hypertrophy mr 2014-05-20T21:23:25Z biological_process owl:Class
GO:2001106 biolink:NamedThing regulation of Rho guanyl-nucleotide exchange factor activity Any process that modulates the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. got7fsn_ti regulation of RhoGEF|regulation of Rho guanine nucleotide exchange factor yaf 2011-09-23T10:13:06Z biological_process owl:Class
GO:1905097 biolink:NamedThing regulation of guanyl-nucleotide exchange factor activity Any process that modulates the frequency, rate or extent of guanyl-nucleotide exchange factor activity. got7fsn_ti regulation of GNRP|regulation of guanyl-nucleotide release factor activity|regulation of GDS|regulation of guanyl-nucleotide releasing factor|regulation of GDP-dissociation stimulator activity|regulation of GEF https://github.com/geneontology/go-ontology/issues/18750 sl 2016-03-31T16:09:35Z biological_process owl:Class
GO:0071429 biolink:NamedThing snRNA-containing ribonucleoprotein complex export from nucleus The directed movement of a ribonucleoprotein complex that contains small nuclear RNA from the nucleus to the cytoplasm. got7fsn_ti snRNA-containing ribonucleoprotein complex export from cell nucleus|snRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm|snRNA-containing RNP export from nucleus|snRNA-containing ribonucleoprotein complex nucleus export mah 2009-12-16T10:15:38Z biological_process owl:Class
GO:0071426 biolink:NamedThing ribonucleoprotein complex export from nucleus The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm. got7fsn_ti ribonucleoprotein complex export from cell nucleus|RNP export from nucleus|ribonucleoprotein complex nucleus export|ribonucleoprotein complex transport from nucleus to cytoplasm mah 2009-12-16T10:13:01Z biological_process owl:Class
GO:0010469 biolink:NamedThing regulation of signaling receptor activity Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity. got7fsn_ti regulation of signalling receptor activity|regulation of receptor activity biological_process owl:Class
GO:0044476 biolink:NamedThing envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism. got7fsn_ti jl 2012-01-19T02:28:42Z biological_process owl:Class
GO:0044474 biolink:NamedThing envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism. got7fsn_ti jl 2012-01-19T02:25:04Z biological_process owl:Class
GO:0102563 biolink:NamedThing aurachin C monooxygenase activity Catalysis of the reaction: aurachin C + O2 + H+ + NAD(P)H <=> aurachin C epoxide + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-15029 molecular_function owl:Class
GO:0048461 biolink:NamedThing flower structural organization The process that contributes to the act of creating the structural organization of the flower. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti flower structural organisation GO:0048412 biological_process owl:Class
GO:0061570 biolink:NamedThing dCDP phosphorylation The process of introducing a phosphate group into dCDP to produce a dCTP. got7fsn_ti dph 2013-08-01T13:02:16Z biological_process owl:Class
GO:1990708 biolink:NamedThing conditioned place preference The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug. got7fsn_ti sl 2015-03-18T20:28:59Z biological_process owl:Class
GO:0008306 biolink:NamedThing associative learning Learning by associating a stimulus (the cause) with a particular outcome (the effect). got7fsn_ti classical conditioning|conditional learning|Pavlovian conditioning|conditional response Wikipedia:Learning#Associative_learning biological_process owl:Class
GO:0044589 biolink:NamedThing pectin binding Binding to pectin. got7fsn_ti jl 2012-04-26T01:26:56Z molecular_function owl:Class
GO:0048028 biolink:NamedThing galacturonan binding Binding to a simple or complex galacturonan. Galacturonan is any glycan composed solely of galacturonic acid residues, a specific type of glycuronan, and a constituent of some pectins. got7fsn_ti polygalacturonide binding molecular_function owl:Class
GO:0043970 biolink:NamedThing histone H3-K9 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone. got7fsn_ti histone H3K9 acetylation|histone H3 acetylation at K9 biological_process owl:Class
GO:0043966 biolink:NamedThing histone H3 acetylation The modification of histone H3 by the addition of an acetyl group. got7fsn_ti biological_process owl:Class
GO:0036192 biolink:NamedThing 3-hydroxyindolin-2-one monooxygenase activity Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O. got7fsn_ti 3-hydroxyindolin-2-one,NAD(P)H:oxygen oxidoreductase (2-hydroxy-2H-1,4-benzoxazin-3(4H)-one-forming) bf 2012-04-19T11:45:33Z RHEA:31927|KEGG_REACTION:R07422|EC:1.14.14.109 molecular_function owl:Class
GO:0016897 biolink:NamedThing exoribonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters. got7fsn_ti EC:3.1.14.- molecular_function owl:Class
GO:0004532 biolink:NamedThing exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. got7fsn_ti Reactome:R-HSA-429961 molecular_function owl:Class
GO:0036225 biolink:NamedThing cellular response to vitamin B1 starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine). got7fsn_ti cellular response to thiamin starvation|cellular response to vitamin B1 deprivation bf 2012-05-09T02:35:55Z biological_process owl:Class
GO:0007500 biolink:NamedThing mesodermal cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti mesoderm cell fate determination Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'. biological_process owl:Class
GO:0035896 biolink:NamedThing positive regulation of mast cell degranulation in other organism Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism. got7fsn_ti up-regulation of mast cell degranulation in other organism|upregulation of mast cell degranulation in other organism bf 2011-06-15T02:49:03Z biological_process owl:Class
GO:0035895 biolink:NamedThing modulation of mast cell degranulation in other organism Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. got7fsn_ti regulation of mast cell degranulation in other organism bf 2011-06-15T02:46:50Z biological_process owl:Class
GO:0009668 biolink:NamedThing plastid membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid. got7fsn_ti plastid membrane organization and biogenesis|plastid membrane organisation biological_process owl:Class
GO:0032395 biolink:NamedThing MHC class II receptor activity Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti T cell receptor activity|gamma-delta T cell receptor activity|alpha-beta T cell receptor activity Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves. molecular_function owl:Class
GO:0035165 biolink:NamedThing embryonic crystal cell differentiation The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. got7fsn_ti biological_process owl:Class
GO:0021630 biolink:NamedThing olfactory nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. got7fsn_ti CN I maturation biological_process owl:Class
GO:0071003 biolink:NamedThing penta-snRNP complex A ribonucleoprotein complex that is formed by the association of the U1, U2, U4/U6 and U5 small nuclear ribonucleoproteins. got7fsn_ti penta-RNP complex mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0097525 biolink:NamedThing spliceosomal snRNP complex A small ribonucleoprotein complex involved in formation of the spliceosome. got7fsn_ti pr 2013-10-18T15:57:45Z cellular_component owl:Class
GO:0003341 biolink:NamedThing cilium movement The directed, self-propelled movement of a cilium. got7fsn_ti flagellar motility|cilium beating|ciliary motility|flagellar movement|microtubule-based flagellum movement|flagellum movement Note that we deem cilium and microtubule-based flagellum to be equivalent. dph 2009-11-24T09:56:26Z GO:0036142 biological_process owl:Class
GO:0010584 biolink:NamedThing pollen exine formation The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine. got7fsn_ti biological_process owl:Class
GO:0010208 biolink:NamedThing pollen wall assembly The formation of reticulate pollen wall pattern consisting of two layers, exine and intine. got7fsn_ti pollen wall formation biological_process owl:Class
GO:0015986 biolink:NamedThing ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. got7fsn_ti chemiosmosis biological_process owl:Class
GO:0006754 biolink:NamedThing ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. got7fsn_ti ATP formation|ATP biosynthesis|ATP regeneration|ATP synthesis|ATP anabolism GO:0006758|GO:0006759 biological_process owl:Class
GO:0110156 biolink:NamedThing methylguanosine-cap decapping Cleavage of the 5'-methylguanosine-cap of an mRNA. The methylguanosine-cap is present at the 5'-end of eukaryotic mRNAs. Decapping inactivates translation initiation and promotes 5'-to-3' decay of mRNA. got7fsn_ti kmv 2019-07-08T17:31:07Z biological_process owl:Class
GO:0009080 biolink:NamedThing pyruvate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine. got7fsn_ti pyruvate family amino acid degradation|pyruvate family amino acid breakdown|pyruvate family amino acid catabolism biological_process owl:Class
GO:0009078 biolink:NamedThing pyruvate family amino acid metabolic process The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine. got7fsn_ti pyruvate family amino acid metabolism biological_process owl:Class
GO:0050865 biolink:NamedThing regulation of cell activation Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti biological_process owl:Class
GO:0051059 biolink:NamedThing NF-kappaB binding Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. got7fsn_ti molecular_function owl:Class
GO:0061629 biolink:NamedThing RNA polymerase II-specific DNA-binding transcription factor binding Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. got7fsn_ti RNA polymerase II transcription factor binding|RNA polymerase II sequence-specific DNA binding transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II repressing transcription factor binding|RNA polymerase II sequence-specific DNA-binding transcription factor binding https://github.com/geneontology/go-ontology/issues/19354 dph 2014-05-15T09:12:24Z GO:0001103|GO:0001085|GO:0001102 molecular_function owl:Class
GO:0071187 biolink:NamedThing protocadherin-alpha-v4-protocadherin-gamma-b4 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdhga1-Pcdhgb4 complex mah 2009-11-23T04:22:08Z cellular_component owl:Class
GO:0098543 biolink:NamedThing detection of other organism The series of events in which a stimulus from another organism is received and converted into a molecular signal. got7fsn_ti recognition of other organism involved in symbiotic interaction|recognition of other organism during symbiotic interaction https://github.com/geneontology/go-ontology/issues/17977 dos 2013-11-11T14:28:54Z GO:0051824 biological_process owl:Class
GO:0010412 biolink:NamedThing mannan metabolic process The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units. got7fsn_ti mannan metabolism biological_process owl:Class
GO:0050118 biolink:NamedThing N-acetyldiaminopimelate deacetylase activity Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + acetate. got7fsn_ti N-acetyl-L-diaminopimelic acid deacylase activity|N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity|N-acetyl-LL-diaminopimelate deacylase activity|6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity RHEA:20405|MetaCyc:N-ACETYLDIAMINOPIMELATE-DEACETYLASE-RXN|KEGG_REACTION:R02733|EC:3.5.1.47 molecular_function owl:Class
GO:1990255 biolink:NamedThing subsynaptic reticulum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane. got7fsn_ti tb 2013-12-13T23:05:21Z biological_process owl:Class
GO:0006996 biolink:NamedThing organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. got7fsn_ti organelle organization and biogenesis|single-organism organelle organization|single organism organelle organization|organelle organisation jl 2013-12-19T15:25:51Z GO:1902589 biological_process owl:Class
GO:0016993 biolink:NamedThing precorrin-8X methylmutase activity Catalysis of the reaction: precorrin-8X = hydrogenobyrinate. got7fsn_ti HBA synthase activity|hydrogenobyrinic acid-binding protein activity|precorrin isomerase activity|precorrin-8X 11,12-methylmutase activity RHEA:22512|MetaCyc:5.4.1.2-RXN|EC:5.4.99.61 molecular_function owl:Class
GO:0016867 biolink:NamedThing intramolecular transferase activity, transferring acyl groups Catalysis of the transfer of an acyl group from one position to another within a single molecule. got7fsn_ti EC:5.4.1.- molecular_function owl:Class
GO:0034867 biolink:NamedThing 2,4,4-trimethylpent-2-enoyl-CoA hydratase activity Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA. got7fsn_ti UM-BBD_reactionID:r1277 molecular_function owl:Class
GO:0004711 biolink:NamedThing ribosomal protein S6 kinase activity Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. got7fsn_ti molecular_function owl:Class
GO:0004674 biolink:NamedThing protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. got7fsn_ti protein threonine kinase activity|serine/threonine protein kinase activity|protein serine kinase activity|threonine-specific protein kinase activity|protein-serine kinase activity|protein phosphokinase activity|protein kinase (phosphorylating) activity|serine kinase activity|protein serine-threonine kinase activity|serine(threonine) protein kinase activity|serine-specific protein kinase activity|serine protein kinase activity https://github.com/geneontology/go-ontology/issues/20114 GO:0106311|GO:0004696|GO:0004695|GO:0004700 Reactome:R-HSA-75809|Reactome:R-HSA-5679205|Reactome:R-HSA-111919|Reactome:R-HSA-442832|Reactome:R-HSA-2029460|Reactome:R-HSA-193705|Reactome:R-HSA-5682101|Reactome:R-HSA-450474|Reactome:R-HSA-165726|Reactome:R-HSA-199298|Reactome:R-HSA-5672828|Reactome:R-HSA-5624492|Reactome:R-HSA-936951|Reactome:R-HSA-6799409|Reactome:R-HSA-2399977|Reactome:R-HSA-111970|Reactome:R-HSA-8873929|Reactome:R-HSA-450325|Reactome:R-HSA-2028673|Reactome:R-HSA-6798372|Reactome:R-HSA-201691|Reactome:R-HSA-5687183|RHEA:46608|Reactome:R-HSA-3229102|Reactome:R-HSA-9653503|Reactome:R-HSA-2028635|Reactome:R-HSA-9648089|Reactome:R-HSA-5687086|Reactome:R-HSA-195318|Reactome:R-HSA-5683801|Reactome:R-HSA-1445144|Reactome:R-HSA-3239014|Reactome:R-HSA-5668545|Reactome:R-HSA-8868666|Reactome:R-HSA-1225894|Reactome:R-HSA-8878050|Reactome:R-HSA-188350|Reactome:R-HSA-5672948|Reactome:R-HSA-5668984|Reactome:R-HSA-9619515|Reactome:R-HSA-428961|Reactome:R-HSA-3928608|Reactome:R-HSA-8868340|Reactome:R-HSA-5218821|Reactome:R-HSA-6795460|Reactome:R-HSA-5671763|Reactome:R-HSA-166245|Reactome:R-HSA-9619843|Reactome:R-HSA-1362270|Reactome:R-HSA-2399941|Reactome:R-HSA-448955|Reactome:R-HSA-5607722|Reactome:R-HSA-450222|Reactome:R-HSA-975861|Reactome:R-HSA-9610156|Reactome:R-HSA-975865|Reactome:R-HSA-1168635|Reactome:R-HSA-6805399|Reactome:R-HSA-937022|Reactome:R-HSA-399950|Reactome:R-HSA-5684887|Reactome:R-HSA-1181355|Reactome:R-HSA-170977|Reactome:R-HSA-5669250|Reactome:R-HSA-163416|Reactome:R-HSA-975125|Reactome:R-HSA-5685230|Reactome:R-HSA-5683964|Reactome:R-HSA-5213464|Reactome:R-HSA-450463|Reactome:R-HSA-198599|Reactome:R-HSA-8853444|Reactome:R-HSA-380272|Reactome:R-HSA-9645535|Reactome:R-HSA-9656214|Reactome:R-HSA-1549526|Reactome:R-HSA-6814409|Reactome:R-HSA-5674496|Reactome:R-HSA-5357831|Reactome:R-HSA-9612501|Reactome:R-HSA-1181149|Reactome:R-HSA-2730876|Reactome:R-HSA-2028583|Reactome:R-HSA-6795290|Reactome:R-HSA-6802973|Reactome:R-HSA-5632670|Reactome:R-HSA-374696|Reactome:R-HSA-400382|Reactome:R-HSA-199935|Reactome:R-HSA-176116|Reactome:R-HSA-3228469|Reactome:R-HSA-75028|Reactome:R-HSA-392752|Reactome:R-HSA-5682598|Reactome:R-HSA-9634702|Reactome:R-HSA-349444|Reactome:R-HSA-2399981|Reactome:R-HSA-139918|Reactome:R-HSA-913996|Reactome:R-HSA-975180|Reactome:R-HSA-6802919|Reactome:R-HSA-5693598|Reactome:R-HSA-8878054|Reactome:R-HSA-2294580|Reactome:R-HSA-5687094|Reactome:R-HSA-5675198|Reactome:R-HSA-3858480|Reactome:R-HSA-5213466|Reactome:R-HSA-2028589|Reactome:R-HSA-9613530|Reactome:R-HSA-187688|Reactome:R-HSA-9008822|Reactome:R-HSA-975170|Reactome:R-HSA-377186|Reactome:R-HSA-4551570|Reactome:R-HSA-211164|Reactome:R-HSA-2060328|Reactome:R-HSA-198371|Reactome:R-HSA-2028598|Reactome:R-HSA-8939963|Reactome:R-HSA-5692768|Reactome:R-HSA-2984226|Reactome:R-HSA-934559|Reactome:R-HSA-8868260|Reactome:R-HSA-199910|Reactome:R-HSA-3371531|Reactome:R-HSA-9012319|Reactome:R-HSA-6805126|Reactome:R-HSA-9023132|Reactome:R-HSA-446694|Reactome:R-HSA-8948039|Reactome:R-HSA-8944454|Reactome:R-HSA-3209160|Reactome:R-HSA-2422927|Reactome:R-HSA-6805640|Reactome:R-HSA-9694293|Reactome:R-HSA-170055|Reactome:R-HSA-1168641|Reactome:R-HSA-156723|Reactome:R-HSA-69685|Reactome:R-HSA-3928640|Reactome:R-HSA-448948|Reactome:R-HSA-389756|Reactome:R-HSA-8940100|Reactome:R-HSA-9612509|Reactome:R-HSA-3857329|Reactome:R-HSA-163010|Reactome:R-HSA-5687121|Reactome:R-HSA-5357472|Reactome:R-HSA-5627775|Reactome:R-HSA-5682983|Reactome:R-HSA-6800490|Reactome:R-HSA-5682026|Reactome:R-HSA-975874|Reactome:R-HSA-156699|Reactome:R-HSA-211583|Reactome:R-HSA-975160|Reactome:R-HSA-5610718|Reactome:R-HSA-2730896|Reactome:R-HSA-5218854|Reactome:R-HSA-2399966|Reactome:R-HSA-5635842|Reactome:R-HSA-2168079|Reactome:R-HSA-8877691|Reactome:R-HSA-9032751|Reactome:R-HSA-198609|Reactome:R-HSA-381091|Reactome:R-HSA-164151|Reactome:R-HSA-429016|Reactome:R-HSA-5668947|Reactome:R-HSA-5672978|Reactome:R-HSA-6802933|Reactome:R-HSA-8948146|Reactome:R-HSA-5668932|Reactome:R-HSA-8952289|Reactome:R-HSA-9032863|Reactome:R-HSA-975134|Reactome:R-HSA-202510|Reactome:R-HSA-166284|Reactome:R-HSA-5218826|Reactome:R-HSA-3000327|Reactome:R-HSA-3249371|Reactome:R-HSA-5685242|Reactome:R-HSA-2399996|Reactome:R-HSA-5672973|Reactome:R-HSA-5229343|Reactome:R-HSA-2243938|Reactome:R-HSA-9620004|Reactome:R-HSA-109823|Reactome:R-HSA-9612980|Reactome:R-HSA-5260201|Reactome:R-HSA-156678|Reactome:R-HSA-2730868|Reactome:R-HSA-6805276|Reactome:R-HSA-198270|Reactome:R-HSA-168140|Reactome:R-HSA-165758|Reactome:R-HSA-8852306|Reactome:R-HSA-209087|Reactome:R-HSA-5607732|Reactome:R-HSA-2028591|Reactome:R-HSA-9610153|Reactome:R-HSA-176298|Reactome:R-HSA-9627089|Reactome:R-HSA-5693551|Reactome:R-HSA-109862|Reactome:R-HSA-4332388|Reactome:R-HSA-3928616|Reactome:R-HSA-112342|Reactome:R-HSA-170076|Reactome:R-HSA-5607742|Reactome:R-HSA-3928625|Reactome:R-HSA-156673|Reactome:R-HSA-9610163|Reactome:R-HSA-2574840|Reactome:R-HSA-1592233|Reactome:R-HSA-912470|Reactome:R-HSA-9009208|Reactome:R-HSA-381111|Reactome:R-HSA-349455|Reactome:R-HSA-6804276|Reactome:R-HSA-6811454|Reactome:R-HSA-5218814|Reactome:R-HSA-5686704|Reactome:R-HSA-112381|Reactome:R-HSA-3769394|Reactome:R-HSA-9626880|Reactome:R-HSA-3222020|Reactome:R-HSA-2029454|Reactome:R-HSA-199917|Reactome:R-HSA-198611|Reactome:R-HSA-2399992|Reactome:R-HSA-4411383|Reactome:R-HSA-8863895|Reactome:R-HSA-109822|Reactome:R-HSA-200421|Reactome:R-HSA-2470508|Reactome:R-HSA-9632868|Reactome:R-HSA-109860|Reactome:R-HSA-2430535|Reactome:R-HSA-156682|Reactome:R-HSA-3132737|Reactome:R-HSA-2399985|Reactome:R-HSA-5218906|Reactome:R-HSA-6788392|Reactome:R-HSA-199839|Reactome:R-HSA-9656215|Reactome:R-HSA-6802935|Reactome:R-HSA-2993898|Reactome:R-HSA-9648883|Reactome:R-HSA-201677|Reactome:R-HSA-198746|Reactome:R-HSA-6805479|Reactome:R-HSA-198731|Reactome:R-HSA-9648888|Reactome:R-HSA-5693549|Reactome:R-HSA-1449597|Reactome:R-HSA-8850945|Reactome:R-HSA-139908|Reactome:R-HSA-9013978|Reactome:R-HSA-165182|Reactome:R-HSA-8863007|Reactome:R-HSA-5687101|Reactome:R-HSA-8868573|Reactome:R-HSA-1458463|Reactome:R-HSA-2029469|Reactome:R-HSA-399952|Reactome:R-HSA-2984258|Reactome:R-HSA-8948757|Reactome:R-HSA-195275|RHEA:17989|Reactome:R-HSA-6802911|Reactome:R-HSA-8863014|Reactome:R-HSA-187949|Reactome:R-HSA-9008480|Reactome:R-HSA-166286|Reactome:R-HSA-975853|Reactome:R-HSA-2562526|Reactome:R-HSA-2396007|Reactome:R-HSA-5675194|Reactome:R-HSA-9662823|Reactome:R-HSA-349426|Reactome:R-HSA-5684140|Reactome:R-HSA-8868344|Reactome:R-HSA-1181156|Reactome:R-HSA-6805785|Reactome:R-HSA-5671919|Reactome:R-HSA-199895|Reactome:R-HSA-3239019|Reactome:R-HSA-442739|Reactome:R-HSA-6798374|Reactome:R-HSA-5693536|Reactome:R-HSA-5610730|Reactome:R-HSA-195287|Reactome:R-HSA-399944|Reactome:R-HSA-202541|Reactome:R-HSA-201717|Reactome:R-HSA-5693575|Reactome:R-HSA-5693609|Reactome:R-HSA-6801666|Reactome:R-HSA-3928577|Reactome:R-HSA-5683792|EC:2.7.11.1|Reactome:R-HSA-2399999|Reactome:R-HSA-446701|Reactome:R-HSA-165766|Reactome:R-HSA-3371567|Reactome:R-HSA-2028679|Reactome:R-HSA-3857328|Reactome:R-HSA-9683664|Reactome:R-HSA-5675868|Reactome:R-HSA-9681627|Reactome:R-HSA-9652165|Reactome:R-HSA-450827|Reactome:R-HSA-3000310|Reactome:R-HSA-6805059|Reactome:R-HSA-8868567|Reactome:R-HSA-202222|Reactome:R-HSA-6804955|Reactome:R-HSA-174119|Reactome:R-HSA-5665868|Reactome:R-HSA-937059|Reactome:R-HSA-9633008|Reactome:R-HSA-2028555|Reactome:R-HSA-5683425|Reactome:R-HSA-5692775|Reactome:R-HSA-8853419|Reactome:R-HSA-419087|Reactome:R-HSA-2028675|Reactome:R-HSA-2990880|Reactome:R-HSA-2028661|Reactome:R-HSA-5607726|Reactome:R-HSA-2730856|Reactome:R-HSA-5357477|Reactome:R-HSA-3371435|Reactome:R-HSA-5632672|Reactome:R-HSA-2529020|Reactome:R-HSA-445072|Reactome:R-HSA-198756|Reactome:R-HSA-5635841|Reactome:R-HSA-5610732|Reactome:R-HSA-199929|Reactome:R-HSA-166119|Reactome:R-HSA-174174|Reactome:R-HSA-8870558|Reactome:R-HSA-77071|Reactome:R-HSA-6799097|Reactome:R-HSA-399978|Reactome:R-HSA-167098|Reactome:R-HSA-450490|Reactome:R-HSA-1632857|Reactome:R-HSA-9694620|Reactome:R-HSA-165718|Reactome:R-HSA-8868118|Reactome:R-HSA-4332358|Reactome:R-HSA-165777|Reactome:R-HSA-419197|Reactome:R-HSA-9673346|Reactome:R-HSA-4088134|Reactome:R-HSA-69891|Reactome:R-HSA-1638803|Reactome:R-HSA-199863|Reactome:R-HSA-193647|Reactome:R-HSA-5082405|Reactome:R-HSA-975878|Reactome:R-HSA-165692|Reactome:R-HSA-165162|Reactome:R-HSA-442724|Reactome:R-HSA-9007539|Reactome:R-HSA-399951|Reactome:R-HSA-399939|Reactome:R-HSA-198621|Reactome:R-HSA-8876446|Reactome:R-HSA-5578777|Reactome:R-HSA-5666160|Reactome:R-HSA-2466068|Reactome:R-HSA-6795473|Reactome:R-HSA-3928620|Reactome:R-HSA-9604328|Reactome:R-HSA-2400001|Reactome:R-HSA-5228811|Reactome:R-HSA-1168638|Reactome:R-HSA-5693540|Reactome:R-HSA-2399988|Reactome:R-HSA-2028629|Reactome:R-HSA-5672010|Reactome:R-HSA-5672008|Reactome:R-HSA-1454699|Reactome:R-HSA-2243942|Reactome:R-HSA-5610722|Reactome:R-HSA-162657|Reactome:R-HSA-419083|Reactome:R-HSA-69604|Reactome:R-HSA-162363|Reactome:R-HSA-170116|Reactome:R-HSA-4332363|Reactome:R-HSA-6805103|Reactome:R-HSA-429714|Reactome:R-HSA-5690250|Reactome:R-HSA-211650|Reactome:R-HSA-933525|Reactome:R-HSA-2730900|Reactome:R-HSA-5685156|Reactome:R-HSA-451152|Reactome:R-HSA-198347|Reactome:R-HSA-450499|Reactome:R-HSA-198640|Reactome:R-HSA-6801675|Reactome:R-HSA-5686578|Reactome:R-HSA-3222006|Reactome:R-HSA-8852317|Reactome:R-HSA-167084|Reactome:R-HSA-6799246|Reactome:R-HSA-8863011|Reactome:R-HSA-5687090|Reactome:R-HSA-918229|Reactome:R-HSA-6810233|Reactome:R-HSA-170087|Reactome:R-HSA-200143|Reactome:R-HSA-6799332|Reactome:R-HSA-198669|Reactome:R-HSA-109702|Reactome:R-HSA-451347|Reactome:R-HSA-75820|Reactome:R-HSA-2399982|Reactome:R-HSA-163418|Reactome:R-HSA-9022314|Reactome:R-HSA-69608|Reactome:R-HSA-6802943|Reactome:R-HSA-75010|Reactome:R-HSA-8933446|Reactome:R-HSA-5218916|Reactome:R-HSA-2028284|Reactome:R-HSA-5694441|Reactome:R-HSA-1358791|Reactome:R-HSA-6802926|Reactome:R-HSA-5624473|Reactome:R-HSA-202459|Reactome:R-HSA-202500|Reactome:R-HSA-419644|Reactome:R-HSA-2176475|Reactome:R-HSA-6804266|Reactome:R-HSA-2399969|Reactome:R-HSA-5684096|Reactome:R-HSA-195300|Reactome:R-HSA-202437|Reactome:R-HSA-199299|Reactome:R-HSA-5692779|Reactome:R-HSA-170126|Reactome:R-HSA-4411402|Reactome:R-HSA-8942836|Reactome:R-HSA-3772435|Reactome:R-HSA-195283|Reactome:R-HSA-3229152|Reactome:R-HSA-8856813|Reactome:R-HSA-8854908|Reactome:R-HSA-198613|Reactome:R-HSA-432110|Reactome:R-HSA-168053|Reactome:R-HSA-4793911|Reactome:R-HSA-9624526|Reactome:R-HSA-9699579|Reactome:R-HSA-5082387|Reactome:R-HSA-2214351|Reactome:R-HSA-2028670|Reactome:R-HSA-9633742|Reactome:R-HSA-6805285|Reactome:R-HSA-4608825 molecular_function owl:Class
GO:0004131 biolink:NamedThing cytosine deaminase activity Catalysis of the reaction: cytosine + H2O = uracil + NH3. got7fsn_ti cytosine aminohydrolase activity|isocytosine deaminase activity RHEA:20605|MetaCyc:CYTDEAM-RXN|EC:3.5.4.1 molecular_function owl:Class
GO:0044490 biolink:NamedThing positive regulation of voltage-gated sodium channel activity in other organism Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. got7fsn_ti jl 2012-02-01T12:21:26Z biological_process owl:Class
GO:0044488 biolink:NamedThing modulation of voltage-gated sodium channel activity in other organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. got7fsn_ti jl 2012-02-01T11:48:25Z biological_process owl:Class
GO:0007279 biolink:NamedThing pole cell formation Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells. got7fsn_ti See also the Cell Ontology term 'pole cell ; CL:0000301'. biological_process owl:Class
GO:0048703 biolink:NamedThing embryonic viscerocranium morphogenesis The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones. got7fsn_ti embryonic pharyngeal skeleton morphogenesis biological_process owl:Class
GO:0042631 biolink:NamedThing cellular response to water deprivation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water. got7fsn_ti cellular response to drought biological_process owl:Class
GO:0071462 biolink:NamedThing cellular response to water stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water. got7fsn_ti mah 2009-12-18T11:32:44Z biological_process owl:Class
GO:0001754 biolink:NamedThing eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms. got7fsn_ti biological_process owl:Class
GO:0048232 biolink:NamedThing male gamete generation Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction. got7fsn_ti biological_process owl:Class
GO:0007276 biolink:NamedThing gamete generation The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. got7fsn_ti gametogenesis GO:0009552 biological_process owl:Class
GO:0050767 biolink:NamedThing regulation of neurogenesis Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system. got7fsn_ti biological_process owl:Class
GO:0044829 biolink:NamedThing positive regulation by host of viral genome replication A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication. got7fsn_ti jl 2014-02-06T11:35:07Z biological_process owl:Class
GO:0044827 biolink:NamedThing modulation by host of viral genome replication A process in which a host organism modulates the frequency, rate or extent of viral genome replication. got7fsn_ti regulation by host of viral genome reproduction jl 2014-02-06T11:26:45Z biological_process owl:Class
GO:0015951 biolink:NamedThing purine ribonucleotide interconversion The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide. got7fsn_ti biological_process owl:Class
GO:0015950 biolink:NamedThing purine nucleotide interconversion The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide. got7fsn_ti biological_process owl:Class
GO:0009644 biolink:NamedThing response to high light intensity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. got7fsn_ti biological_process owl:Class
GO:0009642 biolink:NamedThing response to light intensity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus. got7fsn_ti biological_process owl:Class
GO:0039629 biolink:NamedThing T=219 icosahedral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins. got7fsn_ti bf 2012-08-03T16:29:00Z cellular_component owl:Class
GO:0019030 biolink:NamedThing icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure. got7fsn_ti quasispherical viral capsid cellular_component owl:Class
GO:0071986 biolink:NamedThing Ragulator complex A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signalling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). got7fsn_ti GTPase-containing complex for Gap1p sorting in the endosome|MAPKSP1/ROBLD3/C11orf59 complex|EGO complex|EGO-GSE complex|GSE complex|Rag GEF https://github.com/geneontology/go-ontology/issues/20822|https://github.com/geneontology/go-ontology/issues/21777 mah 2010-10-22T02:42:13Z GO:0034449|GO:0034448 cellular_component owl:Class
GO:0032045 biolink:NamedThing guanyl-nucleotide exchange factor complex A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. got7fsn_ti cellular_component owl:Class
GO:0044850 biolink:NamedThing menstrual cycle A type of ovulation cycle where the endometrium is shed if pregnancy does not occur. got7fsn_ti jl 2014-07-16T13:51:29Z Wikipedia:Menstrual_cycle biological_process owl:Class
GO:0035592 biolink:NamedThing establishment of protein localization to extracellular region The directed movement of a protein to a specific location within the extracellular region. got7fsn_ti establishment of protein localization in extracellular region|establishment of protein localisation in extracellular region bf 2010-11-09T10:25:08Z biological_process owl:Class
GO:0033422 biolink:NamedThing CCC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CCC codon. got7fsn_ti proline tRNA Note that in the standard genetic code, CCC codes for proline. molecular_function owl:Class
GO:0031174 biolink:NamedThing lifelong otolith mineralization The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added. got7fsn_ti biological_process owl:Class
GO:0036521 biolink:NamedThing modulation by symbiont of host protein localization to phagocytic vesicle Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host protein localisation to phagosome bf 2016-06-06T14:47:10Z biological_process owl:Class
GO:0044068 biolink:NamedThing modulation by symbiont of host cellular process Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism. got7fsn_ti regulation by symbiont of host cellular process|regulation of host cellular process by symbiont|modulation of host cellular process by symbiont biological_process owl:Class
GO:0034523 biolink:NamedThing 3-formylsalicylate oxidase activity Catalysis of the reaction: 3-formylsalicylic acid + O2 + H2O = 2-hydroxyisophthalic acid + hydrogen peroxide. got7fsn_ti UM-BBD_reactionID:r0777 molecular_function owl:Class
GO:0043614 biolink:NamedThing multi-eIF complex A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5. got7fsn_ti multifactor translation initiation factor (eIF) complex cellular_component owl:Class
GO:0072156 biolink:NamedThing distal tubule morphogenesis The process in which the anatomical structures of a distal tubule are generated and organized. The distal tubule is a nephron tubule that begins at the macula densa and extends to the connecting tubule. got7fsn_ti mah 2010-02-24T02:32:03Z biological_process owl:Class
GO:0072078 biolink:NamedThing nephron tubule morphogenesis The process in which the anatomical structures of a nephron tubule are generated and organized. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. got7fsn_ti mah 2010-02-01T02:25:14Z biological_process owl:Class
GO:0090709 biolink:NamedThing regulation of timing of plant organ formation Any process that modulates the rate, frequency or extent of plant organ formation at a consistent predetermined time point during development. got7fsn_ti tb 2016-10-05T12:49:58Z biological_process owl:Class
GO:1905428 biolink:NamedThing regulation of plant organ formation Any process that modulates the frequency, rate or extent of plant organ formation. got7fsn_ti tb 2016-09-07T18:57:47Z biological_process owl:Class
GO:0051358 biolink:NamedThing peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus. got7fsn_ti biosynthesis of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 2-imino-glutamic acid 5-imidazolinone glycine See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. RESID:AA0378 biological_process owl:Class
GO:0019756 biolink:NamedThing cyanogenic glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. got7fsn_ti cyanogenic glycoside synthesis|cyanogenic glycoside anabolism|cyanogenic glycoside formation|cyanogenic glycoside biosynthesis biological_process owl:Class
GO:0008110 biolink:NamedThing L-histidine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate. got7fsn_ti histidine-2-oxoglutarate aminotransferase activity|histidine aminotransferase activity|histidine transaminase activity KEGG_REACTION:R01161|RHEA:16565|MetaCyc:HISTTRANSAM-RXN|EC:2.6.1.38 molecular_function owl:Class
GO:0000133 biolink:NamedThing polarisome Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p. got7fsn_ti cellular_component owl:Class
GO:0019125 biolink:NamedThing peptidyl-phenylalanine racemization The racemization of peptidyl-phenylalanine. got7fsn_ti GO:0018089|GO:0018371 RESID:AA0194 biological_process owl:Class
GO:0035838 biolink:NamedThing growing cell tip The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs. got7fsn_ti growing cell end bf 2011-05-06T01:28:44Z cellular_component owl:Class
GO:0030427 biolink:NamedThing site of polarized growth Any part of a cell where non-isotropic growth takes place. got7fsn_ti GO:0030483|GO:0000134 cellular_component owl:Class
GO:0102744 biolink:NamedThing all-trans-geranyl-geranyl diphosphate reductase activity Catalysis of the reaction: H+ + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + NADPH = dihydrogeranylgeranyl-PP + NADP. got7fsn_ti MetaCyc:RXN-7658 molecular_function owl:Class
GO:0031982 biolink:NamedThing vesicle Any small, fluid-filled, spherical organelle enclosed by membrane. got7fsn_ti membrane-enclosed vesicle|membrane-bounded vesicle GO:0031988 Wikipedia:Vesicle_(biology)|NIF_Subcellular:sao221389602 cellular_component owl:Class
GO:0043227 biolink:NamedThing membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. got7fsn_ti membrane-enclosed organelle NIF_Subcellular:sao414196390 cellular_component owl:Class
GO:0102811 biolink:NamedThing geraniol 10-hydroxylase activity Catalysis of the reaction: geraniol + O2 + NADPH + H+ <=> (6E)-8-hydroxygeraniol + NADP + H2O. got7fsn_ti RHEA:32495|MetaCyc:RXN-8197|EC:1.14.14.83 molecular_function owl:Class
GO:0018589 biolink:NamedThing di-n-butyltin dioxygenase activity Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin. got7fsn_ti DBT dioxygenase activity UM-BBD_reactionID:r0645 molecular_function owl:Class
GO:0007036 biolink:NamedThing vacuolar calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings. got7fsn_ti biological_process owl:Class
GO:1990096 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to superoxide Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. got7fsn_ti pr 2013-05-07T12:25:34Z biological_process owl:Class
GO:1990095 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. got7fsn_ti pr 2013-05-07T12:10:32Z biological_process owl:Class
GO:0034421 biolink:NamedThing post-translational protein acetylation The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome. got7fsn_ti posttranslational protein amino acid acetylation|post-translational protein amino acid acetylation biological_process owl:Class
GO:0002541 biolink:NamedThing activation of plasma proteins involved in acute inflammatory response Any process activating plasma proteins by proteolysis as part of an acute inflammatory response. got7fsn_ti biological_process owl:Class
GO:0016051 biolink:NamedThing carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. got7fsn_ti carbohydrate formation|carbohydrate biosynthesis|carbohydrate anabolism|anabolic carbohydrate metabolic process|anabolic carbohydrate metabolism|carbohydrate synthesis GO:0006093 biological_process owl:Class
GO:0033164 biolink:NamedThing glycolipid 1,6-alpha-mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage. got7fsn_ti GDP-mannose:glycolipid 1,6-alpha-D-mannosyltransferase activity|GDP-mannose:oligosaccharide 1,6-alpha-D-mannosyltransferase activity|glycolipid 6-alpha-mannosyltransferase activity|initiation-specific alpha-1,6-mannosyltransferase activity|GDP-mannose:oligosaccharide 6-alpha-D-mannosyltransferase activity EC:2.4.1.232|MetaCyc:2.4.1.232-RXN molecular_function owl:Class
GO:0004376 biolink:NamedThing glycolipid mannosyltransferase activity Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage. got7fsn_ti glycolipid mannosyl transferase activity GO:0004580 Reactome:R-HSA-162873|Reactome:R-HSA-162821 molecular_function owl:Class
GO:0070463 biolink:NamedThing tubulin-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of a tubulin dimer to accelerate release of ADP and phosphate. got7fsn_ti tubulin-activated ATPase activity molecular_function owl:Class
GO:0140657 biolink:NamedThing ATP-dependent activity A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient. got7fsn_ti ATPase activity, coupled|ATPase-dependent activity|ATP hydrolysis-dependent activity https://github.com/geneontology/go-ontology/issues/21612 Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'. pg 2021-06-15T07:35:06Z molecular_function owl:Class
GO:0061785 biolink:NamedThing peptidoglycan endopeptidase activity An endopeptidase activity that uses peptidoglycan as a substrate. got7fsn_ti dph 2016-09-07T16:30:48Z molecular_function owl:Class
GO:0061783 biolink:NamedThing peptidoglycan muralytic activity A catalytic activity that contributes to the degradation of peptidoglycan. got7fsn_ti dph 2016-09-07T15:47:49Z molecular_function owl:Class
GO:0052680 biolink:NamedThing epi-isozizaene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-epi-isozizaene + diphosphate. got7fsn_ti (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-epi-isozizaene-forming] activity KEGG_REACTION:R07830|MetaCyc:RXN-9349|RHEA:25992|EC:4.2.3.37 molecular_function owl:Class
GO:0009560 biolink:NamedThing embryo sac egg cell differentiation The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana. got7fsn_ti female gamete generation|female gametophyte egg cell differentiation GO:0048233 biological_process owl:Class
GO:0042254 biolink:NamedThing ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis. got7fsn_ti ribosome biogenesis and assembly GO:0007046 biological_process owl:Class
GO:0022613 biolink:NamedThing ribonucleoprotein complex biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. got7fsn_ti ribonucleoprotein complex biogenesis and assembly|RNA-protein complex biogenesis biological_process owl:Class
GO:0007292 biolink:NamedThing female gamete generation Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction. got7fsn_ti biological_process owl:Class
GO:0071160 biolink:NamedThing cyanophycin synthetase activity (L-aspartate-adding) Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n + L-Asp = ADP + phosphate + [L-Asp(4-L-Arg)]n-L-Asp. got7fsn_ti mah 2009-11-17T05:18:17Z RHEA:13277|EC:6.3.2.29 molecular_function owl:Class
GO:0043860 biolink:NamedThing cyanophycin synthetase activity Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer). got7fsn_ti cphA EC:6.3.1.- molecular_function owl:Class
GO:0003320 biolink:NamedThing heart rudiment involution The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube. got7fsn_ti dph 2009-10-27T09:29:24Z biological_process owl:Class
GO:0003152 biolink:NamedThing morphogenesis of an epithelial fold involved in embryonic heart tube formation The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation. got7fsn_ti tb 2009-09-23T10:10:24Z biological_process owl:Class
GO:0001569 biolink:NamedThing branching involved in blood vessel morphogenesis The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. got7fsn_ti patterning of blood vessels biological_process owl:Class
GO:0023058 biolink:NamedThing adaptation of signaling pathway The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. got7fsn_ti adaptation of signalling pathway 2010-02-16T09:30:50Z biological_process owl:Class
GO:0052611 biolink:NamedThing beta-carotene 3-hydroxylase activity Catalysis of the reaction: beta-carotene + a reduced electron acceptor + oxygen = beta-cryptoxanthin + an oxidized electron acceptor + H2O. got7fsn_ti carotene beta-ring hydroxylase activity|beta-carotene hydroxylase activity|beta-carotene 3-hydroxylase activity MetaCyc:RXN-8025|RHEA:30323 molecular_function owl:Class
GO:0005982 biolink:NamedThing starch metabolic process The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose. got7fsn_ti starch metabolism biological_process owl:Class
GO:0006190 biolink:NamedThing inosine salvage Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis. got7fsn_ti adenine, hypoxanthine and their nucleoside salvage|guanine, xanthine and their nucleoside salvage biological_process owl:Class
GO:0045129 biolink:NamedThing NAD-independent histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone. got7fsn_ti AcuC molecular_function owl:Class
GO:0004407 biolink:NamedThing histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. got7fsn_ti EC:3.5.1.98|RHEA:58196|Reactome:R-HSA-3769447|Reactome:R-HSA-3782637|Reactome:R-HSA-2545253|Reactome:R-HSA-3782655|Reactome:R-HSA-427514|Reactome:R-HSA-433672|MetaCyc:3.5.1.98-RXN|Reactome:R-HSA-3777129|Reactome:R-HSA-6805650|Reactome:R-HSA-2545203 molecular_function owl:Class
GO:0002065 biolink:NamedThing columnar/cuboidal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. got7fsn_ti biological_process owl:Class
GO:0030855 biolink:NamedThing epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. got7fsn_ti biological_process owl:Class
GO:0003238 biolink:NamedThing conus arteriosus development The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. got7fsn_ti dph 2009-10-13T11:20:57Z biological_process owl:Class
GO:0050283 biolink:NamedThing serine-sulfate ammonia-lyase activity Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate. got7fsn_ti serine-sulphate ammonia-lyase activity|(L-SOS)lyase activity|L-serine-O-sulfate ammonia-lyase (pyruvate-forming) MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN|EC:4.3.1.10|RHEA:15605 molecular_function owl:Class
GO:0034654 biolink:NamedThing nucleobase-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. got7fsn_ti nucleobase, nucleoside, nucleotide and nucleic acid anabolism|nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis|nucleobase, nucleoside, nucleotide and nucleic acid synthesis|nucleobase, nucleoside, nucleotide and nucleic acid formation biological_process owl:Class
GO:0097747 biolink:NamedThing RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. got7fsn_ti pr 2016-12-02T11:48:55Z molecular_function owl:Class
GO:0015322 biolink:NamedThing secondary active oligopeptide transmembrane transporter activity Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. got7fsn_ti oligopeptide porter activity molecular_function owl:Class
GO:0052845 biolink:NamedThing inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. got7fsn_ti ai 2011-12-05T10:59:20Z MetaCyc:RXN-10964 molecular_function owl:Class
GO:0052842 biolink:NamedThing inositol diphosphate pentakisphosphate diphosphatase activity Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate. got7fsn_ti ai 2011-11-29T04:14:22Z Reactome:R-HSA-1855198|KEGG_REACTION:R05779|Reactome:R-HSA-2023971|RHEA:22384|EC:3.6.1.52 molecular_function owl:Class
GO:0036374 biolink:NamedThing glutathione hydrolase activity Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. got7fsn_ti glutathionase activity|gamma-glutamyltranspeptidase activity bf 2013-05-07T09:58:07Z Reactome:R-HSA-5602984|Reactome:R-HSA-9035966|Reactome:R-HSA-5433072|Reactome:R-HSA-9026916|Reactome:R-HSA-8943279|EC:3.4.19.13|RHEA:28807|Reactome:R-HSA-9026927|Reactome:R-HSA-9026907|Reactome:R-HSA-9026757|Reactome:R-HSA-9026912|Reactome:R-HSA-1222712|KEGG_REACTION:R00494|MetaCyc:RXN-12618|Reactome:R-HSA-266046 molecular_function owl:Class
GO:0008242 biolink:NamedThing omega peptidase activity Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes. got7fsn_ti peptidase activity, acting on peptides containing modified amino acids EC:3.4.19.2|MetaCyc:3.4.19.9-RXN|EC:3.4.19.-|EC:3.4.19.9|MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN molecular_function owl:Class
GO:0004147 biolink:NamedThing dihydrolipoamide branched chain acyltransferase activity Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain. got7fsn_ti dihydrolipoamide branched chain transacylase activity molecular_function owl:Class
GO:0030523 biolink:NamedThing dihydrolipoamide S-acyltransferase activity Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide. got7fsn_ti EC:2.3.1.12 molecular_function owl:Class
GO:0034093 biolink:NamedThing positive regulation of maintenance of sister chromatid cohesion Any process that increases the extent to which the association between sister chromatids of a replicated chromosome is maintained. got7fsn_ti biological_process owl:Class
GO:0045876 biolink:NamedThing positive regulation of sister chromatid cohesion Any process that activates or increases the frequency, rate or extent of sister chromatid cohesion. got7fsn_ti upregulation of sister chromatid cohesion|stimulation of sister chromatid cohesion|up regulation of sister chromatid cohesion|activation of sister chromatid cohesion|up-regulation of sister chromatid cohesion biological_process owl:Class
GO:0022870 biolink:NamedThing protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti mannose PTS transporter activity molecular_function owl:Class
GO:0102976 biolink:NamedThing versiconal reductase activity Catalysis of the reaction: versiconol + NADP <=> versiconal hemiacetal + NADPH + H+. got7fsn_ti RHEA:35699|MetaCyc:RXN-9491|EC:1.1.1.353 molecular_function owl:Class
GO:0080117 biolink:NamedThing secondary growth Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of secondary vascular tissues by the vascular cambium. got7fsn_ti cambial secondary growth Occurs in vascular plants, including gymnosperms and most dicotyledons. Commonly supplemented by activity of the cork cambium or phellogen (PO:0005599). Monocotyledons do not have secondary growth, but may undergo primary thickening (GO:0080192) or secondary thickening (GO:0080191), which can give the appearance of secondary growth. Primary and secondary growth can occur simultaneously in the same organism. dhl 2009-04-27T03:36:28Z biological_process owl:Class
GO:0080190 biolink:NamedThing lateral growth Growth of a plant axis (shoot axis or root) that originates from a lateral meristem. got7fsn_ti Includes thickening of plant axes (PO:0025004) due to the activity of a cambium (PO:0005597), known as secondary growth and found in most gymnosperms and dicotyledons, a primary thickening meristem (PO:0005039) as found in many monocotyledons, some ferns and some cycads, or secondary thickening meristem, (PO:0025414) as found in some monocotyledons. dhl 2012-12-06T15:42:28Z biological_process owl:Class
GO:0001741 biolink:NamedThing XY body A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. got7fsn_ti cellular_component owl:Class
GO:0003207 biolink:NamedThing cardiac chamber formation The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart. got7fsn_ti heart chamber formation dph 2009-10-13T09:29:13Z biological_process owl:Class
GO:0031929 biolink:NamedThing TOR signaling A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors. got7fsn_ti TOR signalling pathway|TOR signal transduction|TOR signaling cascade|target of rapamycin signaling pathway|TOR signaling pathway|target of rapamycin signalling pathway Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'. biological_process owl:Class
GO:0035556 biolink:NamedThing intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. got7fsn_ti protein kinase cascade|intracellular signaling pathway|intracellular signal transduction pathway|intracellular protein kinase cascade|signal transmission via intracellular cascade|intracellular signaling cascade|intracellular signaling chain|signal transduction via intracellular signaling cascade bf 2010-05-14T01:14:37Z GO:0007242|GO:0023013|GO:0007243|GO:0023034 biological_process owl:Class
GO:0038062 biolink:NamedThing protein tyrosine kinase collagen receptor activity Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. got7fsn_ti collagen RTK activity|discoidin domain receptor bf 2012-01-18T01:38:40Z molecular_function owl:Class
GO:0038064 biolink:NamedThing collagen receptor activity Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti transmembrane collagen receptor activity bf 2012-01-18T01:52:42Z molecular_function owl:Class
GO:0070251 biolink:NamedThing pristanate-CoA ligase activity Catalysis of the reaction: ATP + pristanate + CoA = AMP + diphosphate + pristanoyl-CoA. got7fsn_ti pristanate:CoA ligase (AMP-forming)|pristanoyl-CoA ligase activity RHEA:47264|Reactome:R-HSA-389632 molecular_function owl:Class
GO:1990649 biolink:NamedThing inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate. got7fsn_ti al 2015-02-23T11:12:10Z molecular_function owl:Class
GO:0052743 biolink:NamedThing inositol tetrakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. got7fsn_ti ai 2011-09-14T01:31:39Z molecular_function owl:Class
GO:0031899 biolink:NamedThing chromoplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma. got7fsn_ti cellular_component owl:Class
GO:0040030 biolink:NamedThing regulation of molecular function, epigenetic Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. got7fsn_ti regulation of protein activity, epigenetic biological_process owl:Class
GO:0065009 biolink:NamedThing regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. got7fsn_ti regulation of a molecular function biological_process owl:Class
GO:0042017 biolink:NamedThing interleukin-22 binding Binding to interleukin-22. got7fsn_ti IL-22 binding molecular_function owl:Class
GO:1903707 biolink:NamedThing negative regulation of hemopoiesis Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis. got7fsn_ti inhibition of blood cell formation|negative regulation of blood cell formation|inhibition of blood cell biosynthesis|down-regulation of blood cell biosynthesis|down-regulation of haemopoiesis|negative regulation of hematopoiesis|inhibition of hemopoiesis|downregulation of haemopoiesis|negative regulation of haemopoiesis|down regulation of hematopoiesis|down regulation of hemopoiesis|negative regulation of blood cell biosynthesis|down regulation of blood cell formation|downregulation of hemopoiesis|down regulation of haemopoiesis|downregulation of blood cell formation|inhibition of haemopoiesis|downregulation of hematopoiesis|inhibition of hematopoiesis|down-regulation of blood cell formation|down-regulation of hemopoiesis|down regulation of blood cell biosynthesis|downregulation of blood cell biosynthesis|down-regulation of hematopoiesis An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. pad 2014-12-04T15:34:21Z biological_process owl:Class
GO:0007469 biolink:NamedThing antennal development The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli. got7fsn_ti biological_process owl:Class
GO:0035114 biolink:NamedThing imaginal disc-derived appendage morphogenesis The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism. got7fsn_ti biological_process owl:Class
GO:0085041 biolink:NamedThing arbuscule Highly branched symbiont haustoria within host root cortex cells, responsible for nutrient exchange. got7fsn_ti See also: periarbuscular membrane ; GO:0085042. jl 2010-07-27T04:29:03Z cellular_component owl:Class
GO:0085035 biolink:NamedThing haustorium A projection from a cell or tissue that penetrates the host's cell wall and invaginates the host cell membrane. got7fsn_ti See also: extrahaustorial matrix ; GO:0085036 and extrahaustorial membrane ; GO:0085037. jl 2010-07-27T03:42:24Z cellular_component owl:Class
GO:0002150 biolink:NamedThing hypochlorous acid catabolic process The chemical reactions and pathways resulting in the breakdown of hypochlorous acid. got7fsn_ti HOCl catabolic process|hypochlorite catabolic process|hypochlorous acid catabolism|HClO catabolic process hjd 2009-10-13T10:36:09Z biological_process owl:Class
GO:0042000 biolink:NamedThing translocation of peptides or proteins into host The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti translocation of peptides or proteins into other organism during symbiotic interaction|transport of peptides or proteins into host|translocation of peptides or proteins into other organism involved in symbiotic interaction|transport of peptides or proteins into other organism during symbiotic interaction GO:0051808 biological_process owl:Class
GO:0007485 biolink:NamedThing imaginal disc-derived male genitalia development The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. got7fsn_ti male genital development biological_process owl:Class
GO:0007484 biolink:NamedThing imaginal disc-derived genitalia development The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. got7fsn_ti genital development biological_process owl:Class
GO:0018859 biolink:NamedThing 4-hydroxybenzoate-CoA ligase activity Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA. got7fsn_ti 4-hydroxybenzoate:CoA ligase (AMP-forming)|4-hydroxybenzoate-coenzyme A ligase (AMP-forming)|4-hydroxybenzoyl-CoA ligase activity|4-hydroxybenzoate-CoA synthetase activity|4-hydroxybenzoyl coenzyme A synthetase activity RHEA:23116|UM-BBD_reactionID:r0156|EC:6.2.1.27|MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN|KEGG_REACTION:R01300 molecular_function owl:Class
GO:0018173 biolink:NamedThing peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine. got7fsn_ti peptidyl-1-thioglycine synthesis from peptidyl-glycine|peptidyl-1-thioglycine anabolism from peptidyl-glycine|peptidyl-1-thioglycine formation from peptidyl-glycine RESID:AA0265 biological_process owl:Class
GO:0043316 biolink:NamedThing cytotoxic T cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. got7fsn_ti cytotoxic T-cell granule exocytosis|cytotoxic T lymphocyte degranulation|cytotoxic T-lymphocyte degranulation|cytotoxic T cell granule exocytosis|cytotoxic T-lymphocyte granule exocytosis|cytotoxic T lymphocyte granule exocytosis|cytotoxic T-cell degranulation biological_process owl:Class
GO:0002286 biolink:NamedThing T cell activation involved in immune response The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. got7fsn_ti T lymphocyte activation during immune response|T-cell activation during immune response|T cell activation during immune response|T-lymphocyte activation during immune response biological_process owl:Class
GO:0046331 biolink:NamedThing lateral inhibition Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells. got7fsn_ti biological_process owl:Class
GO:0044503 biolink:NamedThing modulation of G protein-coupled receptor activity in other organism The process in which an organism effects a change in the activity of a G protein-coupled receptor in a second organism. got7fsn_ti modulation of G-protein coupled receptor activity in other organism jl 2012-02-23T04:20:07Z biological_process owl:Class
GO:0044504 biolink:NamedThing modulation of receptor activity in other organism The process in which an organism effects a change in the activity of a receptor in a second organism. got7fsn_ti jl 2012-02-23T04:21:41Z biological_process owl:Class
GO:0090573 biolink:NamedThing RNA polymerase IV transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter. got7fsn_ti tb 2014-05-09T13:26:16Z cellular_component owl:Class
GO:0009931 biolink:NamedThing calcium-dependent protein serine/threonine kinase activity Calcium-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. got7fsn_ti These reactions are dependent on the presence of calcium ions. molecular_function owl:Class
GO:0010857 biolink:NamedThing calcium-dependent protein kinase activity Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. got7fsn_ti This reaction requires the presence of calcium. Reactome:R-HSA-9005561|Reactome:R-HSA-8986937 molecular_function owl:Class
GO:0001006 biolink:NamedThing RNA polymerase III type 3 promoter sequence-specific DNA binding Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae. got7fsn_ti RNA polymerase III type 3 promoter DNA binding krc 2010-08-18T06:02:26Z GO:0001032 molecular_function owl:Class
GO:0001016 biolink:NamedThing RNA polymerase III transcription regulatory region sequence-specific DNA binding Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. got7fsn_ti RNA polymerase III regulatory region DNA binding krc 2010-08-19T09:36:17Z molecular_function owl:Class
GO:0033612 biolink:NamedThing receptor serine/threonine kinase binding Binding to a receptor that possesses protein serine/threonine kinase activity. got7fsn_ti transmembrane receptor protein serine/threonine kinase ligand binding molecular_function owl:Class
GO:0060037 biolink:NamedThing pharyngeal system development The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear. got7fsn_ti biological_process owl:Class
GO:0048731 biolink:NamedThing system development The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. got7fsn_ti biological_process owl:Class
GO:1900558 biolink:NamedThing austinol metabolic process The chemical reactions and pathways involving austinol. got7fsn_ti austinol metabolism di 2012-05-15T06:26:58Z biological_process owl:Class
GO:1990593 biolink:NamedThing nascent polypeptide-associated complex binding Binding to nascent polypeptide-associated complex, a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. got7fsn_ti NAC binding|NACA binding mcc 2014-12-15T22:20:45Z molecular_function owl:Class
GO:0102321 biolink:NamedThing 2,2'-hydroxybiphenyl monooxygenase activity Catalysis of the reaction: biphenyl-2,2'-diol + O2 + NADH + H+ <=> biphenyl-2,2',3-triol + H2O + NAD. got7fsn_ti EC:1.14.13.44|MetaCyc:MONOMER-17239|RHEA:63512 molecular_function owl:Class
GO:0110054 biolink:NamedThing regulation of actin filament annealing Any process that modulates the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. got7fsn_ti kmv 2017-09-20T20:07:58Z biological_process owl:Class
GO:0110053 biolink:NamedThing regulation of actin filament organization Any process that modulates the frequency, rate or extent of actin filament organization. got7fsn_ti kmv 2017-09-20T19:52:57Z biological_process owl:Class
GO:0019824 biolink:NamedThing P6 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes. got7fsn_ti peroxisome vesicle Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'. cellular_component owl:Class
GO:0005777 biolink:NamedThing peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. got7fsn_ti peroxisomal|peroxisome vesicle GO:0019818 NIF_Subcellular:sao499555322|Wikipedia:Peroxisome cellular_component owl:Class
GO:1990861 biolink:NamedThing Ubp3-Bre5 deubiquitination complex A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p. got7fsn_ti Ubp3-Bre5 ubiquitin protease complex rb 2015-09-24T17:56:53Z cellular_component owl:Class
GO:0000045 biolink:NamedThing autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. got7fsn_ti PAS formation|autophagic vacuole assembly|autophagosome formation|autophagic vacuole formation|autophagosome biosynthesis biological_process owl:Class
GO:0035074 biolink:NamedThing pupation The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period. got7fsn_ti head eversion|prepupal-pupal transition Wikipedia:Pupa biological_process owl:Class
GO:0097043 biolink:NamedThing histone H3-K56 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone. got7fsn_ti pr 2011-04-19T05:18:29Z biological_process owl:Class
GO:0050285 biolink:NamedThing sinapine esterase activity Catalysis of the reaction: O-sinapoylcholine + H(2)O = choline + H(+) + sinapate. got7fsn_ti sinapoylcholine sinapohydrolase activity|aromatic choline esterase activity RHEA:10016|EC:3.1.1.49|MetaCyc:SINAPINE-ESTERASE-RXN|KEGG_REACTION:R02381 molecular_function owl:Class
GO:0042149 biolink:NamedThing cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose. got7fsn_ti biological_process owl:Class
GO:0042922 biolink:NamedThing neuromedin U receptor binding Binding to one or more specific sites on a neuromedin U receptor. got7fsn_ti molecular_function owl:Class
GO:0031967 biolink:NamedThing organelle envelope A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. got7fsn_ti cellular_component owl:Class
GO:0030706 biolink:NamedThing germarium-derived oocyte differentiation The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster. got7fsn_ti oocyte cell differentiation biological_process owl:Class
GO:0009994 biolink:NamedThing oocyte differentiation The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete. got7fsn_ti oocyte cell differentiation biological_process owl:Class
GO:0019135 biolink:NamedThing deoxyhypusine monooxygenase activity Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O. got7fsn_ti deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)|DOHH activity|deoxyhypusine dioxygenase activity|deoxyhypusine hydroxylase activity RHEA:14101|Reactome:R-HSA-204662|MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN|EC:1.14.99.29 molecular_function owl:Class
GO:0002711 biolink:NamedThing positive regulation of T cell mediated immunity Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. got7fsn_ti upregulation of T cell mediated immunity|positive regulation of T-cell mediated immunity|up regulation of T cell mediated immunity|activation of T cell mediated immunity|positive regulation of T-lymphocyte mediated immunity|positive regulation of T lymphocyte mediated immunity|up-regulation of T cell mediated immunity|stimulation of T cell mediated immunity biological_process owl:Class
GO:0052043 biolink:NamedThing modification by symbiont of host cellular component The process in which an organism effects a change in the structure or function of a host cellular component. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0010005 biolink:NamedThing cortical microtubule, transverse to long axis Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition. got7fsn_ti cellular_component owl:Class
GO:0055028 biolink:NamedThing cortical microtubule Arrays of microtubules underlying and connected to the plasma membrane in the cortical cytosol. got7fsn_ti cellular_component owl:Class
GO:0042463 biolink:NamedThing ocellus photoreceptor cell development Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus. got7fsn_ti non-eye photoreceptor development GO:0001749 biological_process owl:Class
GO:0042461 biolink:NamedThing photoreceptor cell development Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. got7fsn_ti photoreceptor morphogenesis GO:0046531 biological_process owl:Class
GO:0046027 biolink:NamedThing phospholipid:diacylglycerol acyltransferase activity Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol. got7fsn_ti PDAT activity|phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity EC:2.3.1.158|MetaCyc:2.3.1.158-RXN|RHEA:14057 molecular_function owl:Class
GO:2000255 biolink:NamedThing negative regulation of male germ cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation. got7fsn_ti dph 2010-11-18T09:29:47Z biological_process owl:Class
GO:0018745 biolink:NamedThing epoxide hydrolase A activity Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol. got7fsn_ti UM-BBD_enzymeID:e0049|EC:3.3.2.- molecular_function owl:Class
GO:0000226 biolink:NamedThing microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. got7fsn_ti microtubule cytoskeleton organisation|microtubule dynamics|microtubule cytoskeleton organization and biogenesis biological_process owl:Class
GO:0034911 biolink:NamedThing phthalate 3,4-dioxygenase activity Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+. got7fsn_ti UM-BBD_reactionID:r1444|EC:1.14.12.- molecular_function owl:Class
GO:0007207 biolink:NamedThing phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). got7fsn_ti muscarinic acetylcholine receptor, phospholipase C activating pathway|activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|muscarinic receptor signaling pathway via activation of PLC|activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway biological_process owl:Class
GO:0007213 biolink:NamedThing G protein-coupled acetylcholine receptor signaling pathway Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti acetylcholine receptor signalling, muscarinic pathway|muscarinic acetylcholine receptor signaling pathway|G-protein coupled acetylcholine receptor signaling pathway biological_process owl:Class
GO:0033273 biolink:NamedThing response to vitamin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. got7fsn_ti biological_process owl:Class
GO:0097706 biolink:NamedThing vascular endothelial cell response to oscillatory fluid shear stress Any response to oscillatory fluid shear stress that occurs in a vascular endothelial cell. got7fsn_ti blood vessel endothelial cell response to oscillatory fluid shear stress pr 2016-01-27T14:25:34Z biological_process owl:Class
GO:0097704 biolink:NamedThing cellular response to oscillatory fluid shear stress Any response to oscillatory fluid shear stress that occurs at the level of a cell. got7fsn_ti pr 2016-01-27T14:20:54Z biological_process owl:Class
GO:0051047 biolink:NamedThing positive regulation of secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue. got7fsn_ti upregulation of secretion|up-regulation of secretion|up regulation of secretion|activation of secretion|stimulation of secretion biological_process owl:Class
GO:0050580 biolink:NamedThing 2,5-didehydrogluconate reductase activity Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+. got7fsn_ti 2-dehydro-D-gluconate:NADP+ 2-oxidoreductase activity|YqhE reductase|2,5-diketo-D-gluconate reductase activity EC:1.1.1.274|MetaCyc:1.1.1.274-RXN|RHEA:23828 molecular_function owl:Class
GO:0050695 biolink:NamedThing benzoylformate decarboxylase activity Catalysis of the reaction: benzoylformate = benzaldehyde + CO2. got7fsn_ti phenylglyoxylate decarboxylase activity|benzoylformate carboxy-lyase activity|benzoylformate carboxy-lyase (benzaldehyde-forming) UM-BBD_reactionID:r1049|MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN|EC:4.1.1.7|RHEA:23368 molecular_function owl:Class
GO:0021942 biolink:NamedThing radial glia guided migration of Purkinje cell The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer. got7fsn_ti biological_process owl:Class
GO:0021932 biolink:NamedThing hindbrain radial glia guided cell migration The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain. got7fsn_ti biological_process owl:Class
GO:0050632 biolink:NamedThing propionyl-CoA C2-trimethyltridecanoyltransferase activity Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA. got7fsn_ti sterol carrier protein|sterol carrier protein X-related thiolase activity|3-oxopristanoyl-CoA thiolase activity|oxopristanoyl-CoA thiolase activity|peroxisomal 3-oxoacyl coenzyme A thiolase|4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA C2-4,8,12-trimethyltridecanoyltransferase activity|peroxisome sterol carrier protein thiolase|3-oxopristanoyl-CoA hydrolase activity|propionyl-CoA C(2)-trimethyltridecanoyltransferase activity|4,8,12-trimethyltridecanoyl-CoA:propanoyl-CoA 2-C-4,8,12-trimethyltridecanoyltransferase activity|SCPx GO:0004770 Reactome:R-HSA-2066781|RHEA:10408|MetaCyc:2.3.1.154-RXN|Reactome:R-HSA-390224|KEGG_REACTION:R05330|Reactome:R-HSA-193533|EC:2.3.1.176|Reactome:R-HSA-192341 molecular_function owl:Class
GO:0070985 biolink:NamedThing transcription factor TFIIK complex A transcription factor complex that forms part of the holo TFIIH complex. In Saccharomyces/human, TFIIK contains Ccl1p/Cyclin H, Tfb3p/MAT1 and Kin28p/CDK7. got7fsn_ti TFIIK complex|cyclin H-CDK7 complex|Mcs6/Mcs2/Pmh1 complex mah 2009-10-27T04:19:37Z cellular_component owl:Class
GO:0070117 biolink:NamedThing organellar chromatophore thylakoid lumen The volume enclosed by an organellar chromatophore thylakoid membrane. got7fsn_ti Paulinella-type chromatophore thylakoid lumen cellular_component owl:Class
GO:0061119 biolink:NamedThing regulation of positive chemotaxis to cAMP by chlorinated alkylphenone Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. got7fsn_ti dph 2010-05-17T07:53:58Z biological_process owl:Class
GO:0061118 biolink:NamedThing regulation of positive chemotaxis to cAMP Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. got7fsn_ti dph 2010-05-17T07:47:47Z biological_process owl:Class
GO:0019573 biolink:NamedThing D-arabinose catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate. got7fsn_ti D-arabinose breakdown to xylulose 5-phosphate|D-arabinose degradation to xylulose 5-phosphate MetaCyc:DARABCAT-PWY biological_process owl:Class
GO:0046905 biolink:NamedThing 15-cis-phytoene synthase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate -> 15-cis-phytoene + 2 diphosphate. got7fsn_ti phytoene synthase activity https://github.com/geneontology/go-ontology/issues/21165 Note that this should not be confused with 'geranylgeranyl-diphosphate geranylgeranyltransferase activity ; GO:0016767', EC:2.5.1.32. This activity is the second part of the formation of phytoene from geranylgeranyl-diphosphate, the first stage of which is catalyzed by EC:2.5.1.32. RHEA:34479 molecular_function owl:Class
GO:0097209 biolink:NamedThing epidermal lamellar body A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. got7fsn_ti pr 2012-01-04T02:34:27Z cellular_component owl:Class
GO:0042599 biolink:NamedThing lamellar body A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. got7fsn_ti Odland body|lamellar granule|membrane-coating granule|keratinosome NIF_Subcellular:sao1379604862 cellular_component owl:Class
GO:0008328 biolink:NamedThing ionotropic glutamate receptor complex A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. got7fsn_ti cellular_component owl:Class
GO:1990426 biolink:NamedThing mitotic recombination-dependent replication fork processing Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart. got7fsn_ti homologous recombination-dependent replication fork processing|homologous recombination dependent replication fork recovery mah 2014-07-24T09:42:54Z biological_process owl:Class
GO:0006421 biolink:NamedThing asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA. got7fsn_ti biological_process owl:Class
GO:0006418 biolink:NamedThing tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis. got7fsn_ti tRNA charging MetaCyc:TRNA-CHARGING-PWY biological_process owl:Class
GO:0004656 biolink:NamedThing procollagen-proline 4-dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. got7fsn_ti proline hydroxylase activity|protocollagen proline 4-hydroxylase activity|protocollagen proline hydroxylase activity|protocollagen hydroxylase activity|prolylprotocollagen dioxygenase activity|peptidyl proline hydroxylase activity|procollagen-proline,2-oxoglutarate-4-dioxygenase activity|prolyl hydroxylase activity|proline,2-oxoglutarate 4-dioxygenase activity|collagen proline hydroxylase activity|procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity|prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity|prolylprotocollagen hydroxylase activity|protocollagen prolyl hydroxylase activity|proline, 2-oxoglutarate dioxygenase activity|hydroxylase, collagen proline activity|protocollagen proline dioxygenase activity|prolyl 4-hydroxylase activity|proline protocollagen hydroxylase activity EC:1.14.11.2|MetaCyc:1.14.11.2-RXN|KEGG_REACTION:R03219|RHEA:18945|Reactome:R-HSA-1650808 molecular_function owl:Class
GO:0019798 biolink:NamedThing procollagen-proline dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2. got7fsn_ti molecular_function owl:Class
GO:0019350 biolink:NamedThing teichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. got7fsn_ti teichoic acid formation|teichoic acid anabolism|teichoic acid synthesis|teichoic acid biosynthesis MetaCyc:TEICHOICACID-PWY biological_process owl:Class
GO:0032792 biolink:NamedThing negative regulation of CREB transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB. got7fsn_ti inhibition of CREB transcription factor|CREB inhibitor biological_process owl:Class
GO:0043433 biolink:NamedThing negative regulation of DNA-binding transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. got7fsn_ti negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of androgen receptor activity|negative regulation of DNA binding transcription factor activity|negative regulation of transcription factor activity|inhibition of transcription factor activity|downregulation of transcription factor activity|down regulation of transcription factor activity|down-regulation of transcription factor activity|negative regulation of thyroid hormone receptor activity 2011-07-15T10:56:12Z GO:1904168|GO:2000824 biological_process owl:Class
GO:0042718 biolink:NamedThing yolk granule Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed. got7fsn_ti cellular_component owl:Class
GO:0016404 biolink:NamedThing 15-hydroxyprostaglandin dehydrogenase (NAD+) activity Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+. got7fsn_ti NAD-specific 15-hydroxyprostaglandin dehydrogenase activity|prostaglandin dehydrogenase activity|15-hydroxyprostaglandin dehydrogenase activity|15-hydroxyprostanoic dehydrogenase activity|11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity|NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)|15-OH-PGDH|(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity Reactome:R-HSA-9023968|MetaCyc:1.1.1.141-RXN|EC:1.1.1.141|RHEA:11876|Reactome:R-HSA-9024766|Reactome:R-HSA-2161779|Reactome:R-HSA-2161662 molecular_function owl:Class
GO:0048704 biolink:NamedThing embryonic skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized during the embryonic phase. got7fsn_ti embryonic skeletal morphogenesis biological_process owl:Class
GO:0048705 biolink:NamedThing skeletal system morphogenesis The process in which the anatomical structures of the skeleton are generated and organized. got7fsn_ti skeletal morphogenesis biological_process owl:Class
GO:1990246 biolink:NamedThing uniplex complex A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE. got7fsn_ti mitochondrial uniporter complex|mitochondrial uniporter holocomplex sp 2013-12-04T06:44:35Z cellular_component owl:Class
GO:0034704 biolink:NamedThing calcium channel complex An ion channel complex through which calcium ions pass. got7fsn_ti cellular_component owl:Class
GO:0051293 biolink:NamedThing establishment of spindle localization The directed movement of the spindle to a specific location in the cell. got7fsn_ti spindle positioning|establishment of spindle localisation biological_process owl:Class
GO:0097456 biolink:NamedThing terminal loop Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath. got7fsn_ti terminal loop of Schwann cell pr 2012-12-19T13:04:06Z NIF_Subcellular:sao924713546 cellular_component owl:Class
GO:0004567 biolink:NamedThing beta-mannosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. got7fsn_ti beta-D-mannosidase activity|mannanase activity|beta-mannoside mannohydrolase activity|mannase activity|beta-D-mannoside mannohydrolase activity|exo-beta-D-mannanase activity Reactome:R-HSA-8853710|MetaCyc:3.2.1.25-RXN|EC:3.2.1.25 molecular_function owl:Class
GO:0015923 biolink:NamedThing mannosidase activity Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. got7fsn_ti molecular_function owl:Class
GO:0001099 biolink:NamedThing basal RNA polymerase II transcription machinery binding Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. got7fsn_ti basal RNAP II transcription machinery binding Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. krc 2010-11-24T12:54:33Z molecular_function owl:Class
GO:0004298 biolink:NamedThing threonine-type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. got7fsn_ti multicatalytic proteinase (complex)|tricorn proteinase|proteasome endopeptidase complex|prosome|multicatalytic endopeptidase complex|tricorn protease|26S protease|MCP|ingensin|large multicatalytic protease|alkaline protease|threonine endopeptidase activity|lens neutral proteinase|multicatalytic proteinase EC:3.4.25.- molecular_function owl:Class
GO:0004175 biolink:NamedThing endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. got7fsn_ti elastase activity|endoprotease activity|proteasome endopeptidase activity|proteinase GO:0016809 Reactome:R-HSA-6784676|Reactome:R-HSA-4608855|Reactome:R-HSA-2130282|Reactome:R-HSA-5668520|Reactome:R-HSA-68825|Reactome:R-HSA-5362448|Reactome:R-HSA-3640874|Reactome:R-HSA-9008475|Reactome:R-HSA-5610758|Reactome:R-HSA-180573|Reactome:R-HSA-174203|Reactome:R-HSA-4641260|Reactome:R-HSA-8849797|Reactome:R-HSA-8934819|Reactome:R-HSA-450466|MetaCyc:RXN0-5195|Reactome:R-HSA-187574|Reactome:R-HSA-8854044|Reactome:R-HSA-188191|Reactome:R-HSA-8952408|Reactome:R-HSA-68948|Reactome:R-HSA-74730|Reactome:R-HSA-5607731|Reactome:R-HSA-5610757|Reactome:R-HSA-5658430|Reactome:R-HSA-5610760|Reactome:R-HSA-8939801|Reactome:R-HSA-1236935|Reactome:R-HSA-180603|Reactome:R-HSA-5358340|Reactome:R-HSA-983150|Reactome:R-HSA-174058|Reactome:R-HSA-174255|Reactome:R-HSA-264458|Reactome:R-HSA-5687112|Reactome:R-HSA-8866553|Reactome:R-HSA-5693081|Reactome:R-HSA-174105|Reactome:R-HSA-5387392|Reactome:R-HSA-9008110|Reactome:R-HSA-1168640|Reactome:R-HSA-209061|Reactome:R-HSA-9614271|Reactome:R-HSA-5635868|Reactome:R-HSA-8850992|Reactome:R-HSA-353125|Reactome:R-HSA-9010096|Reactome:R-HSA-4641256|Reactome:R-HSA-5610754|Reactome:R-HSA-3928656|Reactome:R-HSA-75825|Reactome:R-HSA-1234159|Reactome:R-HSA-69600|Reactome:R-HSA-5607724|Reactome:R-HSA-8866858|Reactome:R-HSA-8852354|Reactome:R-HSA-5635854|Reactome:R-HSA-193682|Reactome:R-HSA-9604642|Reactome:R-HSA-69016|Reactome:R-HSA-174202|EC:3.4.99.-|Reactome:R-HSA-8854071|Reactome:R-HSA-8957265|Reactome:R-HSA-211715|Reactome:R-HSA-983158|Reactome:R-HSA-9009362|Reactome:R-HSA-9011313|Reactome:R-HSA-5668481|Reactome:R-HSA-2213200|Reactome:R-HSA-6784628|Reactome:R-HSA-1433374|Reactome:R-HSA-1504193|Reactome:R-HSA-1236970|Reactome:R-HSA-5358460|Reactome:R-HSA-1251997 molecular_function owl:Class
GO:0000729 biolink:NamedThing DNA double-strand break processing The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang. got7fsn_ti biological_process owl:Class
GO:0034497 biolink:NamedThing protein localization to phagophore assembly site Any process in which a protein is transported to, or maintained at, the phagophore assembly site (PAS). got7fsn_ti protein localisation to phagophore assembly site|protein localization to pre-autophagosomal structure|protein localization to PAS biological_process owl:Class
GO:0070518 biolink:NamedThing alpha4-beta1 integrin-CD53 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD53, a member of the tetraspan family. got7fsn_ti ITGA4-ITGB1-CD53 complex cellular_component owl:Class
GO:0002051 biolink:NamedThing osteoblast fate commitment The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. got7fsn_ti biological_process owl:Class
GO:0001222 biolink:NamedThing transcription corepressor binding Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. got7fsn_ti RNA polymerase II transcription corepressor binding https://github.com/geneontology/go-ontology/issues/19354 krc 2012-04-16T03:27:26Z GO:0001226 molecular_function owl:Class
GO:0001221 biolink:NamedThing transcription coregulator binding Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. got7fsn_ti RNA polymerase II transcription coregulator binding|transcription cofactor binding|RNA polymerase II transcription cofactor binding https://github.com/geneontology/go-ontology/issues/19354 krc 2012-04-16T03:19:05Z GO:0001224 molecular_function owl:Class
GO:0014701 biolink:NamedThing junctional sarcoplasmic reticulum membrane The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane. got7fsn_ti cellular_component owl:Class
GO:0033017 biolink:NamedThing sarcoplasmic reticulum membrane The lipid bilayer surrounding the sarcoplasmic reticulum. got7fsn_ti cellular_component owl:Class
GO:0050016 biolink:NamedThing kynurenine 7,8-hydroxylase activity Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor. got7fsn_ti kynurenate 7,8-hydroxylase activity|kynurenic hydroxylase activity|kynurenate,hydrogen-donor:oxygen oxidoreductase (hydroxylating)|kynurenic acid hydroxylase activity MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN|EC:1.14.99.2|RHEA:11968 molecular_function owl:Class
GO:0050497 biolink:NamedThing alkylthioltransferase activity Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring alkylthio groups EC:2.8.4.- molecular_function owl:Class
GO:0016782 biolink:NamedThing transferase activity, transferring sulphur-containing groups Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring sulphur-containing groups https://github.com/geneontology/go-ontology/issues/20486 EC:2.8.-.- molecular_function owl:Class
GO:0052036 biolink:NamedThing suppression by symbiont of host inflammatory response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the inflammatory response of the host organism; the inflammatory response is the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti inhibition by symbiont of host inflammatory response|negative regulation by organism of inflammatory response of other organism involved in symbiotic interaction|down-regulation by symbiont of host inflammatory response|downregulation by symbiont of host inflammatory response|down regulation by symbiont of host inflammatory response|negative regulation by symbiont of host inflammatory response GO:0052260 biological_process owl:Class
GO:0044414 biolink:NamedThing suppression of host defenses by symbiont Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti down-regulation by organism of defense response of other organism during symbiotic interaction|inhibition by organism of defense response of other organism during symbiotic interaction|suppression of defense response of other organism|negative regulation by symbiont of host defense response|down-regulation by symbiont of host defense response|suppression of host defense response|suppression of defenses of other organism involved in symbiotic interaction|down regulation by organism of defense response of other organism during symbiotic interaction|suppression of defense response of other organism involved in symbiotic interaction|negative regulation of host defenses|negative regulation by organism of defense response of other organism involved in symbiotic interaction|negative regulation by organism of defense response of other organism during symbiotic interaction|downregulation by organism of defense response of other organism during symbiotic interaction|downregulation by symbiont of host defense response|down regulation by symbiont of host defense response|inhibition by symbiont of host defense response GO:0052261|GO:0051833|GO:0052037 biological_process owl:Class
GO:0018685 biolink:NamedThing alkane 1-monooxygenase activity Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. got7fsn_ti alkane hydroxylase activity|lauric acid omega-hydroxylase activity|alkane 1-hydroxylase activity|1-hydroxylase activity|alkane monooxygenase activity|alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity|omega-hydroxylase activity|fatty acid omega-hydroxylase activity|fatty acid (omega-1)-hydroxylase activity GO:0008393 RHEA:19341|EC:1.14.15.3|UM-BBD_enzymeID:e0022|MetaCyc:ALKANE-1-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0004876 biolink:NamedThing complement component C3a receptor activity Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti C3a anaphylatoxin receptor activity GO:0004943 molecular_function owl:Class
GO:1901275 biolink:NamedThing tartrate metabolic process The chemical reactions and pathways involving tartrate. got7fsn_ti tartrate metabolism yaf 2012-08-17T14:52:19Z biological_process owl:Class
GO:0097556 biolink:NamedThing left posteriolateral flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body. got7fsn_ti left posteriolateral cilium|left posterolateral cilium|left posterolateral flagellum Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T13:21:09Z cellular_component owl:Class
GO:0097729 biolink:NamedThing 9+2 motile cilium A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme). got7fsn_ti motile 9+2 cilium|sperm flagellum|conventional motile cilium This type of cilia may be present in solitary (so-called flagella, e.g. in sperm) or in multiple copies (so-called conventional motile cilia, e.g. in tracheal epithelium, ependyma or oviduct epithelium). pr 2016-09-27T15:26:34Z cellular_component owl:Class
GO:0021518 biolink:NamedThing spinal cord commissural neuron specification The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway. got7fsn_ti biological_process owl:Class
GO:0015874 biolink:NamedThing norepinephrine transport The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. got7fsn_ti levarterenol transport|noradrenaline transport biological_process owl:Class
GO:0051750 biolink:NamedThing delta3,5-delta2,4-dienoyl-CoA isomerase activity Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA. got7fsn_ti delta5-delta2,4-dienoyl-CoA isomerase activity|delta(3,5),delta(2,4)-dienoyl-coenzyme A isomerase activity GO:0008416 molecular_function owl:Class
GO:0021969 biolink:NamedThing corticospinal neuron axon guidance through the cerebral peduncle The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues. got7fsn_ti corticospinal neuron axon pathfinding through the cerebral peduncle biological_process owl:Class
GO:0034850 biolink:NamedThing isooctane monooxygenase activity Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol. got7fsn_ti UM-BBD_reactionID:r1269|EC:1.13.12.- molecular_function owl:Class
GO:0042883 biolink:NamedThing cysteine transport The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-cysteine transport biological_process owl:Class
GO:0097423 biolink:NamedThing mitochondrion-associated adherens complex An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans. got7fsn_ti mitochondrial adhaerens complex|MAC pr 2012-11-07T13:38:50Z NIF_Subcellular:sao1933817066 cellular_component owl:Class
GO:0004755 biolink:NamedThing saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH. got7fsn_ti epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)|aminoadipic semialdehyde-glutamic reductase activity|6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)|N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)|aminoadipate semialdehyde-glutamate reductase activity|saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity|saccharopine reductase activity|aminoadipic semialdehyde-glutamate reductase activity EC:1.5.1.10|MetaCyc:RXN3O-127|RHEA:10020|KEGG_REACTION:R02315 molecular_function owl:Class
GO:0004753 biolink:NamedThing saccharopine dehydrogenase activity Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor. got7fsn_ti lysine-ketoglutarate reductase activity|lysine-2-oxoglutarate reductase activity molecular_function owl:Class
GO:0004844 biolink:NamedThing uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. got7fsn_ti uracil-DNA glycosylase activity Reactome:R-HSA-110217|Reactome:R-HSA-110215 molecular_function owl:Class
GO:0051357 biolink:NamedThing peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. got7fsn_ti biosynthesis of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine|biosynthetic process of protein-protein cross-link via L-methionyl-L-tyrosyl-2-keto-5-iminopiperazine Note that this predicted modification is now thought not to exist. See the biological process term 'peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine ; GO:0051359'. RESID:AA0377 biological_process owl:Class
GO:0043655 biolink:NamedThing host extracellular space The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream. got7fsn_ti extracellular space of host|host extracellular space cellular_component owl:Class
GO:0018995 biolink:NamedThing host cellular component Any cellular component of a host cell. The host is an organism in which another organism, for instance a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection. got7fsn_ti host organism Wikipedia:Host_(biology) cellular_component owl:Class
GO:0018073 biolink:NamedThing protein bromination The addition of one or more bromine atoms to an amino acid residue in a protein. got7fsn_ti protein amino acid bromination biological_process owl:Class
GO:0052403 biolink:NamedThing negative regulation by host of symbiont catalytic activity Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by host of symbiont enzyme activity|down regulation by host of symbiont enzyme activity|downregulation by host of symbiont protein function|inhibition by host of symbiont protein function|downregulation by host of symbiont enzyme activity|down-regulation by host of symbiont protein function|inhibition by host of symbiont enzyme activity|inhibition of symbiont protein function|down-regulation by host of symbiont enzyme activity|inhibition of symbiont enzyme activity|negative regulation by host of symbiont molecular function|down regulation by host of symbiont protein function GO:0052405 biological_process owl:Class
GO:0030714 biolink:NamedThing anterior/posterior axis specification, follicular epithelium Polarization of the follicle cells of an insect ovary along the anterior/posterior axis. got7fsn_ti anterior/posterior axis determination, follicular epithelium biological_process owl:Class
GO:0050777 biolink:NamedThing negative regulation of immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. got7fsn_ti down regulation of immune response|downregulation of immune response|inhibition of immune response|down-regulation of immune response biological_process owl:Class
GO:0035877 biolink:NamedThing death effector domain binding Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD). got7fsn_ti DED binding For binding to the death domain, consider instead the term 'death domain binding ; GO:0070513'. bf 2011-05-31T09:40:46Z molecular_function owl:Class
GO:0086009 biolink:NamedThing membrane repolarization The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. got7fsn_ti tb 2011-11-10T08:13:18Z biological_process owl:Class
GO:0034220 biolink:NamedThing ion transmembrane transport A process in which an ion is transported across a membrane. got7fsn_ti ATP hydrolysis coupled ion transmembrane transport|transmembrane ion transport|ion membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. GO:0099131 biological_process owl:Class
GO:0005048 biolink:NamedThing signal sequence binding Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. got7fsn_ti signal sequence receptor|protein signal sequence binding|leader sequence binding GO:0008249 molecular_function owl:Class
GO:0042277 biolink:NamedThing peptide binding Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. got7fsn_ti molecular_function owl:Class
GO:0004402 biolink:NamedThing histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. got7fsn_ti histone acetokinase activity|H4/H2 histone acetyltransferase activity|histone lysine acetyltransferase activity|nucleosome-histone acetyltransferase activity|histone transacetylase activity|acetyl-CoA:histone acetyltransferase activity|H2A/H2B histone acetyltransferase activity|H3/H4 histone acetyltransferase activity|H4/H2A acetyltransferase activity|histone acetylase activity Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant. GO:0043166|GO:0046971|GO:0004403|GO:0004404|GO:0004406|GO:0004405 Reactome:R-HSA-3662335|MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN|Reactome:R-HSA-5144542|EC:2.3.1.48|Reactome:R-HSA-3697920|Reactome:R-HSA-3301345|Reactome:R-HSA-3301237|RHEA:21992|Reactome:R-HSA-3321975|Reactome:R-HSA-3321805|Reactome:R-HSA-3697008|Reactome:R-HSA-3662318|Reactome:R-HSA-3451147|Reactome:R-HSA-3318486|Reactome:R-HSA-5250938|Reactome:R-HSA-3318413|Reactome:R-HSA-3321883|Reactome:R-HSA-3318415 molecular_function owl:Class
GO:0010298 biolink:NamedThing dihydrocamalexic acid decarboxylase activity Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+. got7fsn_ti RHEA:34807|MetaCyc:RXN-8275 molecular_function owl:Class
GO:0002947 biolink:NamedThing tumor necrosis factor receptor superfamily complex A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily. got7fsn_ti TNF receptor superfamily complex hjd 2012-12-20T13:26:39Z cellular_component owl:Class
GO:0009712 biolink:NamedThing catechol-containing compound metabolic process The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. got7fsn_ti catechol metabolism|catechol metabolic process biological_process owl:Class
GO:0018958 biolink:NamedThing phenol-containing compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. got7fsn_ti phenol-containing compound metabolism|hydroxybenzene metabolic process|carbolic acid metabolic process|carbolic acid metabolism|hydroxybenzene metabolism Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. UM-BBD_pathwayID:phe biological_process owl:Class
GO:0010688 biolink:NamedThing negative regulation of ribosomal protein gene transcription by RNA polymerase II Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. got7fsn_ti negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter biological_process owl:Class
GO:0000122 biolink:NamedThing negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. got7fsn_ti negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter, global|inhibition of transcription from RNA polymerase II promoter|down regulation of transcription from RNA polymerase II promoter|downregulation of global transcription from RNA polymerase II promoter|negative regulation of gene-specific transcription from RNA polymerase II promoter|down-regulation of global transcription from RNA polymerase II promoter|down-regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from Pol II promoter|downregulation of transcription from RNA polymerase II promoter|inhibition of global transcription from RNA polymerase II promoter|negative regulation of global transcription from Pol II promoter|down regulation of global transcription from RNA polymerase II promoter GO:0010553|GO:0045816 biological_process owl:Class
GO:0034218 biolink:NamedThing ascospore wall chitin metabolic process The chemical reactions and pathways involving ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. got7fsn_ti ascospore wall chitin metabolism biological_process owl:Class
GO:0071966 biolink:NamedThing fungal-type cell wall polysaccharide metabolic process The chemical reactions and pathways involving the polysaccharides which make up the fungal-type cell wall. got7fsn_ti mah 2010-10-14T11:56:47Z biological_process owl:Class
GO:0008127 biolink:NamedThing quercetin 2,3-dioxygenase activity Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO. got7fsn_ti quercetin:oxygen 2,3-oxidoreductase (decyclizing)|flavonol 2,4-oxygenase activity|quercetinase activity Reactome:R-HSA-8953398|RHEA:15381|MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN|KEGG_REACTION:R02156|UM-BBD_reactionID:r0891|EC:1.13.11.24 molecular_function owl:Class
GO:0061820 biolink:NamedThing telomeric D-loop disassembly A telomere loop disassembly process that results in the disassembly of telomeric D-loops. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. got7fsn_ti dph biological_process owl:Class
GO:0090657 biolink:NamedThing telomeric loop disassembly The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication. got7fsn_ti t-loop disassembly|T loop disassembly tb 2015-07-07T13:53:40Z biological_process owl:Class
GO:0052697 biolink:NamedThing xenobiotic glucuronidation The modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion. got7fsn_ti phase II metabolism ai 2011-07-27T05:37:50Z biological_process owl:Class
GO:0019371 biolink:NamedThing cyclooxygenase pathway The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2. got7fsn_ti biological_process owl:Class
GO:0019369 biolink:NamedThing arachidonic acid metabolic process The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. got7fsn_ti arachidonic acid metabolism Wikipedia:Arachidonic_acid biological_process owl:Class
GO:0030959 biolink:NamedThing peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link. got7fsn_ti RESID:AA0367 biological_process owl:Class
GO:0035560 biolink:NamedThing pheophorbidase activity Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a. got7fsn_ti PPD activity|pheophoridase activity|phedase activity bf 2010-05-14T02:39:58Z RHEA:32483|EC:3.1.1.82 molecular_function owl:Class
GO:0018250 biolink:NamedThing peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG. got7fsn_ti peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine|peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine|peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine RESID:AA0181 biological_process owl:Class
GO:0018249 biolink:NamedThing protein dehydration The removal of a water group from a protein amino acid. got7fsn_ti protein amino acid dehydration biological_process owl:Class
GO:0106260 biolink:NamedThing DNA-DNA tethering activity Bridging together two regions of a DNA molecule. got7fsn_ti dsDNA bridging|double-stranded DNA bridging https://github.com/geneontology/go-ontology/issues/19385|https://github.com/geneontology/go-ontology/issues/20503 hjd 2020-05-07T19:53:35Z GO:0140564 molecular_function owl:Class
GO:0050978 biolink:NamedThing magnetoreception by sensory perception of electrical stimulus The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish. got7fsn_ti magnetoreception through electrical stimulus|magnetoreception by electrical stimulus|magnetoreception, using electrical stimulus|magnetoreception, sensory perception of electrical stimulus biological_process owl:Class
GO:0050958 biolink:NamedThing magnetoreception The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light. got7fsn_ti sensory perception of magnetic field|magnetoception Wikipedia:Magnetoception biological_process owl:Class
GO:0061726 biolink:NamedThing mitochondrion disassembly The disaggregation of a mitochondrion into its constituent components. got7fsn_ti mitochondrion degradation dph 2015-07-08T13:59:16Z biological_process owl:Class
GO:0043040 biolink:NamedThing tRNA aminoacylation for nonribosomal peptide biosynthetic process The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis. got7fsn_ti tRNA aminoacylation for nonribosomal peptide synthesis|tRNA aminoacylation for nonribosomal peptide anabolism|tRNA aminoacylation for nonribosomal peptide biosynthesis|tRNA aminoacylation for nonribosomal peptide formation biological_process owl:Class
GO:0043039 biolink:NamedThing tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. got7fsn_ti tRNA charging|aminoacyl-tRNA biosynthesis|aminoacyl-tRNA biosynthetic process biological_process owl:Class
GO:1990450 biolink:NamedThing linear polyubiquitin binding Binding to a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next. got7fsn_ti M1-linked ubiquitin chain binding bf 2014-08-06T11:10:26Z molecular_function owl:Class
GO:0043130 biolink:NamedThing ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. got7fsn_ti Reactome:R-HSA-983152|Reactome:R-HSA-1169404|Reactome:R-HSA-205008 molecular_function owl:Class
GO:0090652 biolink:NamedThing basolateral cytoplasm The region of the cytoplasm located at the basolateral side of the cell. Used in reference to animal polarized epithelial cells. got7fsn_ti tb 2015-07-01T15:46:19Z cellular_component owl:Class
GO:0061176 biolink:NamedThing type Ib terminal bouton Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the tonic release neurotransmitters that will induce the contraction of muscle. Type Ib terminal boutons are larger than type Is terminal boutons. got7fsn_ti type Ib terminal button dph 2010-07-13T09:20:04Z cellular_component owl:Class
GO:0061174 biolink:NamedThing type I terminal bouton Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters that will induce the contraction of muscle. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. got7fsn_ti type I terminal button dph 2010-07-13T09:13:05Z cellular_component owl:Class
GO:0050151 biolink:NamedThing oleate hydratase activity Catalysis of the reaction: (R)-10-hydroxystearate = H(2)O + oleate. got7fsn_ti (R)-10-hydroxystearate 10-hydro-lyase activity|(R)-10-hydroxystearate 10-hydro-lyase (oleate-forming) RHEA:21852|EC:4.2.1.53|KEGG_REACTION:R02813|MetaCyc:OLEATE-HYDRATASE-RXN molecular_function owl:Class
GO:0061658 biolink:NamedThing URM1 conjugating enzyme activity Isoenergetic transfer of URM1 from one protein to another via the reaction X-URM1 + Y -> Y-URM1 + X, where both the X-URM1 and Y-URM1 linkages are thioester bonds between the C-terminal amino acid of URM1 and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:37:26Z molecular_function owl:Class
GO:0062110 biolink:NamedThing negative regulation of DNA recombinase disassembly Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombinase complex disassembly, the disaggregation of a DNA recombinase complex into its constituent components. got7fsn_ti dph 2019-02-05T13:57:35Z biological_process owl:Class
GO:0009973 biolink:NamedThing adenylyl-sulfate reductase activity Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor. got7fsn_ti AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)|adenosine phosphosulfate reductase activity|adenylyl-sulphate reductase activity|APS reductase activity|APS-reductase|AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)|adenosine 5'-phosphosulfate reductase RHEA:24240|MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN|EC:1.8.99.2 molecular_function owl:Class
GO:0007450 biolink:NamedThing dorsal/ventral pattern formation, imaginal disc The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed. got7fsn_ti dorsoventral pattern formation, imaginal disc|dorsal-ventral pattern formation, imaginal disc biological_process owl:Class
GO:0007447 biolink:NamedThing imaginal disc pattern formation The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. got7fsn_ti biological_process owl:Class
GO:0043099 biolink:NamedThing pyrimidine deoxyribonucleoside salvage Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0046126 biolink:NamedThing pyrimidine deoxyribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). got7fsn_ti pyrimidine deoxyribonucleoside formation|pyrimidine deoxyribonucleoside synthesis|pyrimidine deoxyribonucleoside biosynthesis|pyrimidine deoxyribonucleoside anabolism biological_process owl:Class
GO:0060778 biolink:NamedThing primary leaflet morphogenesis The process in which the primary leaflet attains its shape. A primary leaflet is a leaflet that develops directly from the rachis. got7fsn_ti dph 2009-07-25T07:15:48Z biological_process owl:Class
GO:0060794 biolink:NamedThing leaflet morphogenesis The process in which the anatomical structures of the leaflet are generated and organized. got7fsn_ti dph 2009-08-04T02:58:14Z biological_process owl:Class
GO:0051565 biolink:NamedThing negative regulation of smooth endoplasmic reticulum calcium ion concentration Any process that decreases the concentration of calcium ions in the smooth endoplasmic reticulum. got7fsn_ti smooth ER calcium ion concentration reduction|reduction of calcium ion concentration in smooth endoplasmic reticulum|reduction of smooth endoplasmic reticulum calcium ion concentration|smooth endoplasmic reticulum calcium ion concentration reduction|reduction of smooth ER calcium ion concentration|reduction of calcium ion concentration in smooth ER biological_process owl:Class
GO:0032471 biolink:NamedThing negative regulation of endoplasmic reticulum calcium ion concentration Any process that decreases the concentration of calcium ions in the endoplasmic reticulum. got7fsn_ti endoplasmic reticulum calcium ion concentration reduction|reduction of calcium ion concentration in ER|reduction of endoplasmic reticulum calcium ion concentration|reduction of calcium ion concentration in endoplasmic reticulum|reduction of ER calcium ion concentration|ER calcium ion concentration reduction biological_process owl:Class
GO:0052542 biolink:NamedThing defense response by callose deposition Any process in which callose is transported to, and/or maintained in, a specific location during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. got7fsn_ti callose localization during defense response|callose deposition during defense response biological_process owl:Class
GO:0052545 biolink:NamedThing callose localization Any process in which callose is transported to, and/or maintained in, a specific location. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. got7fsn_ti callose localisation biological_process owl:Class
GO:0010399 biolink:NamedThing rhamnogalacturonan I backbone metabolic process The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone. got7fsn_ti rhamnogalacturonan I backbone metabolism biological_process owl:Class
GO:0010395 biolink:NamedThing rhamnogalacturonan I metabolic process The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone. got7fsn_ti rhamnogalacturonan I metabolism|RGI metabolism biological_process owl:Class
GO:0008881 biolink:NamedThing glutamate racemase activity Catalysis of the reaction: L-glutamate = D-glutamate. got7fsn_ti KEGG_REACTION:R00260|RHEA:12813|EC:5.1.1.3|MetaCyc:GLUTRACE-RXN molecular_function owl:Class
GO:0047661 biolink:NamedThing amino-acid racemase activity Catalysis of the reaction: an L-amino acid = a D-amino acid. got7fsn_ti L-amino acid racemase activity MetaCyc:AMINO-ACID-RACEMASE-RXN|RHEA:18317|EC:5.1.1.10 molecular_function owl:Class
GO:0010262 biolink:NamedThing somatic embryogenesis Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes. got7fsn_ti biological_process owl:Class
GO:0009793 biolink:NamedThing embryo development ending in seed dormancy The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana. got7fsn_ti embryogenesis biological_process owl:Class
GO:0031533 biolink:NamedThing mRNA cap methyltransferase complex A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping. got7fsn_ti mRNA (guanine-N7) methyltransferase complex|mRNA capping enzyme complex cellular_component owl:Class
GO:0033927 biolink:NamedThing glucan 1,4-alpha-maltohexaosidase activity Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltohexaose residues from the non-reducing chain ends. got7fsn_ti G6-amylase activity|maltohexaose-producing amylase activity|exo-maltohexaohydrolase activity|1,4-alpha-D-glucan maltohexaohydrolase activity MetaCyc:3.2.1.98-RXN|EC:3.2.1.98 molecular_function owl:Class
GO:0004733 biolink:NamedThing pyridoxamine-phosphate oxidase activity Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide. got7fsn_ti pyridoxamine 5'-phosphate oxidase activity|pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)|pyridoxine (pyridoxamine)phosphate oxidase activity|pyridoxaminephosphate oxidase deaminating|pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)|pyridoxine (pyridoxamine) 5'-phosphate oxidase activity|PMP oxidase activity|pyridoxal 5'-phosphate synthase activity|PdxH|pyridoxamine phosphate oxidase activity Reactome:R-HSA-965079|EC:1.4.3.5|MetaCyc:PMPOXI-RXN|Reactome:R-HSA-965019|RHEA:15817 molecular_function owl:Class
GO:0030029 biolink:NamedThing actin filament-based process Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. got7fsn_ti microfilament-based process biological_process owl:Class
GO:0035497 biolink:NamedThing cAMP response element binding Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. got7fsn_ti cyclic-AMP-responsive element binding|cyclic-AMP response element binding|cyclic AMP response element binding|CRE binding|cAMP-responsive element binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. bf 2010-04-29T09:26:47Z molecular_function owl:Class
GO:0000978 biolink:NamedThing RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. got7fsn_ti RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II promoter proximal region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to cis-regulatory sequences. In bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is usually a synonym for "enhancer". krc 2010-08-10T02:17:19Z GO:0000980 molecular_function owl:Class
GO:0016068 biolink:NamedThing type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. got7fsn_ti immediate hypersensitivity response Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity. Wikipedia:Type_I_hypersensitivity biological_process owl:Class
GO:0002524 biolink:NamedThing hypersensitivity An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system. got7fsn_ti hypersensitivity response Wikipedia:Hypersensitivity biological_process owl:Class
GO:0009855 biolink:NamedThing determination of bilateral symmetry The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry. got7fsn_ti determination of bilateral asymmetry biological_process owl:Class
GO:0102319 biolink:NamedThing 2-deoxystreptamine N-acetyl-D-glucosaminyltransferase activity Catalysis of the reaction: 2-deoxystreptamine(2+) + UDP-N-acetyl-alpha-D-glucosamine <=> H+ + 2'-N-acetylparomamine(2+) + UDP(3-). got7fsn_ti MetaCyc:RXN-13122|RHEA:33947|EC:2.4.1.283 molecular_function owl:Class
GO:0030522 biolink:NamedThing intracellular receptor signaling pathway Any series of molecular signals initiated by a ligand binding to an receptor located within a cell. got7fsn_ti intracellular receptor mediated signaling pathway|intracellular receptor-mediated signalling pathway|intracellular receptor-mediated signaling pathway biological_process owl:Class
GO:0046019 biolink:NamedThing regulation of transcription from RNA polymerase II promoter by pheromones Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter. got7fsn_ti regulation of transcription from Pol II promoter by pheromones biological_process owl:Class
GO:0021694 biolink:NamedThing cerebellar Purkinje cell layer formation The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. got7fsn_ti biological_process owl:Class
GO:0052702 biolink:NamedThing cellular modified histidine catabolic process The chemical reactions and pathways resulting in the breakdown of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. got7fsn_ti cellular histidine derivative degradation|cellular modified histidine degradation|modified histidine catabolic process|cellular modified histidine catabolism|cellular histidine derivative catabolism|histidine derivative catabolic process|cellular histidine derivative breakdown|cellular modified histidine breakdown|modified histidine catabolism|cellular histidine derivative catabolic process ai 2011-08-01T03:48:41Z biological_process owl:Class
GO:0120311 biolink:NamedThing ciliary pro-basal body maturation A process that is carried out at the cellular level which results in the conversion of an immature and partially assembled ciliary pro-basal body into a mature basal body that is capable of nucleating a cilium. got7fsn_ti flagellar probasal body maturation|flagellar pro-basal body maturation|pro-basal body maturation krc 2021-03-26T17:41:59Z biological_process owl:Class
GO:0044782 biolink:NamedThing cilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. got7fsn_ti microtubule-based flagellum organization Note that we deem cilium and microtubule-based flagellum to be equivalent. jl 2013-03-27T15:09:58Z biological_process owl:Class
GO:0048809 biolink:NamedThing analia morphogenesis The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0010759 biolink:NamedThing positive regulation of macrophage chemotaxis Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0071675 biolink:NamedThing regulation of mononuclear cell migration Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body. got7fsn_ti mah 2010-02-16T02:11:53Z biological_process owl:Class
GO:0005856 biolink:NamedThing cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. got7fsn_ti Wikipedia:Cytoskeleton cellular_component owl:Class
GO:0000034 biolink:NamedThing adenine deaminase activity Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3. got7fsn_ti ADase activity|adenine aminohydrolase activity|adenine aminase activity|adenase activity RHEA:23688|EC:3.5.4.2|MetaCyc:ADENINE-DEAMINASE-RXN molecular_function owl:Class
GO:0044363 biolink:NamedThing modulation of potassium channel activity in other organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism. got7fsn_ti jl 2011-10-27T02:19:32Z biological_process owl:Class
GO:0044561 biolink:NamedThing modulation of ion channel activity in other organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism. got7fsn_ti regulation of ion channel activity in other organism jl 2012-04-05T03:48:28Z biological_process owl:Class
GO:0048333 biolink:NamedThing mesodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell. got7fsn_ti mesoderm cell differentiation biological_process owl:Class
GO:0032488 biolink:NamedThing Cdc42 protein signal transduction A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state. got7fsn_ti Cdc42 signaling pathway|cdc42 signalling pathway|Cdc42 signaling biological_process owl:Class
GO:0007266 biolink:NamedThing Rho protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state. got7fsn_ti Rho mediated signal transduction biological_process owl:Class
GO:1990154 biolink:NamedThing enzyme IIA-maltose transporter complex A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter. got7fsn_ti maltose transporter inhibitor complex|EIIA(Glc)-maltose transporter complex|EIIA(Glc)-MalFGK2 complex bhm 2013-08-01T09:27:25Z cellular_component owl:Class
GO:0009407 biolink:NamedThing toxin catabolic process The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. got7fsn_ti toxin breakdown|toxin degradation|toxin catabolism biological_process owl:Class
GO:0030098 biolink:NamedThing lymphocyte differentiation The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin. got7fsn_ti lymphocyte cell differentiation|lymphocytic blood cell differentiation|lymphocyte development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. GO:0046650 biological_process owl:Class
GO:0046649 biolink:NamedThing lymphocyte activation A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti biological_process owl:Class
GO:0061102 biolink:NamedThing stomach neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium. got7fsn_ti gastric neuroendocrine cell differentiation dph 2010-04-28T09:47:07Z biological_process owl:Class
GO:0036258 biolink:NamedThing multivesicular body assembly The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. got7fsn_ti MVB formation|multivesicular body biogenesis|MVB biogenesis bf 2012-06-15T01:12:24Z biological_process owl:Class
GO:0045259 biolink:NamedThing proton-transporting ATP synthase complex A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. got7fsn_ti F1-F0 complex|proton-transporting F-type ATPase complex|hydrogen-transporting ATP synthase complex|hydrogen-translocating F-type ATPase complex GO:0045255 cellular_component owl:Class
GO:0048498 biolink:NamedThing establishment of petal orientation The process that determines the orientation of petals with reference to the central axis. got7fsn_ti biological_process owl:Class
GO:0045990 biolink:NamedThing carbon catabolite regulation of transcription A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. got7fsn_ti regulation of transcription by carbon catabolites biological_process owl:Class
GO:0032420 biolink:NamedThing stereocilium An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles. got7fsn_ti cellular_component owl:Class
GO:0043957 biolink:NamedThing acryloyl-CoA reductase (NADP+) activity Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+. got7fsn_ti acetyl-coenzyme A synthetase|AMP-dependent synthetase and ligase|enoyl-CoA hydratase/isomerase|acryloyl-CoA reductase (NADPH) activity|AMP-dependent synthetase and ligase:enoyl-CoA hydratase/isomerase|acrylyl-CoA reductase (NADPH) activity|acetyl-coenzyme A synthetase/GroES-like domain Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. EC:1.3.1.84|KEGG_REACTION:R00919|RHEA:26454|MetaCyc:RXN-9087 molecular_function owl:Class
GO:0006530 biolink:NamedThing asparagine catabolic process The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid. got7fsn_ti asparagine breakdown|asparagine degradation|asparagine catabolism biological_process owl:Class
GO:0009065 biolink:NamedThing glutamine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. got7fsn_ti glutamine family amino acid degradation|glutamine family amino acid catabolism|glutamine family amino acid breakdown biological_process owl:Class
GO:0004099 biolink:NamedThing chitin deacetylase activity Catalysis of the reaction: chitin + H2O = chitosan + acetate. got7fsn_ti chitin amidohydrolase activity MetaCyc:CHITIN-DEACETYLASE-RXN|RHEA:10464|EC:3.5.1.41 molecular_function owl:Class
GO:0009995 biolink:NamedThing soluble molecule recognition The recognition of soluble molecules in the environment. got7fsn_ti biological_process owl:Class
GO:1990124 biolink:NamedThing messenger ribonucleoprotein complex A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules. got7fsn_ti mRNA-protein complex|mRNP|messenger ribonucleoprotein particle|mRNP complex bf 2013-06-13T09:20:52Z cellular_component owl:Class
GO:0015293 biolink:NamedThing symporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. got7fsn_ti symport|porter activity|cotransporter activity molecular_function owl:Class
GO:0050820 biolink:NamedThing positive regulation of coagulation Any process that activates or increases the frequency, rate or extent of coagulation. got7fsn_ti up-regulation of coagulation|activation of coagulation|upregulation of coagulation|up regulation of coagulation|positive regulation of clotting|stimulation of coagulation biological_process owl:Class
GO:1903429 biolink:NamedThing regulation of cell maturation Any process that modulates the frequency, rate or extent of cell maturation. got7fsn_ti regulation of functional differentiation jl 2014-09-15T13:31:23Z biological_process owl:Class
GO:0060284 biolink:NamedThing regulation of cell development Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0018386 biolink:NamedThing N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine. got7fsn_ti RESID:AA0274 biological_process owl:Class
GO:0031365 biolink:NamedThing N-terminal protein amino acid modification The alteration of the N-terminal amino acid residue in a protein. got7fsn_ti peptide or protein amino-terminal blocking|peptide/protein amino-terminal blocking GO:0018409 biological_process owl:Class
GO:0051249 biolink:NamedThing regulation of lymphocyte activation Any process that modulates the frequency, rate or extent of lymphocyte activation. got7fsn_ti biological_process owl:Class
GO:0045858 biolink:NamedThing positive regulation of molecular function, epigenetic Any heritable epigenetic process that increases the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. got7fsn_ti up-regulation of protein activity, epigenetic|stimulation of protein activity, epigenetic|activation of protein activity, epigenetic|up regulation of protein activity, epigenetic|positive regulation of protein activity, epigenetic|upregulation of protein activity, epigenetic biological_process owl:Class
GO:0044093 biolink:NamedThing positive regulation of molecular function Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. got7fsn_ti jl 2009-04-21T04:11:06Z biological_process owl:Class
GO:0004341 biolink:NamedThing gluconolactonase activity Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. got7fsn_ti lactonase activity|D-glucono-1,5-lactone lactonohydrolase activity|gulonolactonase activity|aldonolactonase activity|glucono-delta-lactonase activity EC:3.1.1.17|RHEA:10440|MetaCyc:GLUCONOLACT-RXN molecular_function owl:Class
GO:0016851 biolink:NamedThing magnesium chelatase activity Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate. got7fsn_ti magnesium-protoporphyrin chelatase activity|protoporphyrin IX magnesium-chelatase activity|Mg-protoporphyrin IX magnesio-lyase activity|Mg-protoporphyrin IX magnesium-lyase activity|magnesium-protoporphyrin IX chelatase activity|protoporphyrin IX Mg-chelatase activity|Mg-protoporphyrin IX chelatase activity|Mg-chelatase activity|magnesium-chelatase activity Note that this was EC:4.99.1.1. MetaCyc:RXN1F-20|KEGG_REACTION:R03877|RHEA:13961|EC:6.6.1.1 molecular_function owl:Class
GO:0051003 biolink:NamedThing ligase activity, forming nitrogen-metal bonds, forming coordination complexes Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex. got7fsn_ti EC:6.6.1.- molecular_function owl:Class
GO:0045987 biolink:NamedThing positive regulation of smooth muscle contraction Any process that activates or increases the frequency, rate or extent of smooth muscle contraction. got7fsn_ti upregulation of smooth muscle contraction|stimulation of smooth muscle contraction|activation of smooth muscle contraction|up regulation of smooth muscle contraction|up-regulation of smooth muscle contraction biological_process owl:Class
GO:0045933 biolink:NamedThing positive regulation of muscle contraction Any process that activates or increases the frequency, rate or extent of muscle contraction. got7fsn_ti activation of muscle contraction|up-regulation of muscle contraction|upregulation of muscle contraction|stimulation of muscle contraction|up regulation of muscle contraction biological_process owl:Class
GO:0047075 biolink:NamedThing 2,5-dihydroxypyridine 5,6-dioxygenase activity Catalysis of the reaction: H2O + O2 + 2,5-dihydroxypyridine = formate + maleamate. got7fsn_ti pyridine-2,5-diol dioxygenase activity|2,5-dihydroxypyridine oxygenase activity|2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase activity UM-BBD_reactionID:r1443|MetaCyc:1.13.11.9-RXN|RHEA:27522|EC:1.13.11.9 molecular_function owl:Class
GO:0002417 biolink:NamedThing B cell antigen processing and presentation mediated by B cell receptor uptake of antigen B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor. got7fsn_ti B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen|B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen|B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen biological_process owl:Class
GO:0018094 biolink:NamedThing protein polyglycylation The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid. got7fsn_ti RESID:AA0201 biological_process owl:Class
GO:0030634 biolink:NamedThing carbon fixation by acetyl-CoA pathway A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2). got7fsn_ti acetyl CoA pathway|Ljungdahl-Wood pathway|reductive acetyl CoA pathway MetaCyc:CODH-PWY|Wikipedia:Wood-Ljungdahl_pathway biological_process owl:Class
GO:0006085 biolink:NamedThing acetyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. got7fsn_ti acetyl-CoA anabolism|acetyl-CoA biosynthesis|acetyl-CoA formation|acetyl-CoA synthesis MetaCyc:PWY-5173 biological_process owl:Class
GO:0060639 biolink:NamedThing positive regulation of salivary gland formation by mesenchymal-epithelial signaling Any process that induces the formation of the salivary gland field by means of the secretion of a signal by a mesenchymal cell and its reception and interpretation by an epithelial cell resulting in it adopting the identity of a salivary gland bud cell. got7fsn_ti positive regulation of salivary gland formation by mesenchymal-epithelial signalling dph 2009-05-20T04:26:43Z biological_process owl:Class
GO:0035795 biolink:NamedThing negative regulation of mitochondrial membrane permeability Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. got7fsn_ti negative regulation of transport across mitochondrial membrane|mitochondrial membrane impermeabilization|mitochondrial membrane impermeability bf 2011-04-11T01:45:26Z biological_process owl:Class
GO:1905709 biolink:NamedThing negative regulation of membrane permeability Any process that stops, prevents or reduces the frequency, rate or extent of the passage or uptake of molecules by a membrane. got7fsn_ti hbye 2016-11-18T13:10:42Z biological_process owl:Class
GO:0090606 biolink:NamedThing single-species surface biofilm formation A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface. got7fsn_ti multicellular pellicle formation tb 2014-09-16T14:47:11Z GO:0032022 biological_process owl:Class
GO:0090604 biolink:NamedThing surface biofilm formation A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. got7fsn_ti tb 2014-09-16T14:38:45Z biological_process owl:Class
GO:0001553 biolink:NamedThing luteinization The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation. got7fsn_ti luteal phase Wikipedia:Luteal_phase|Wikipedia:Luteinization biological_process owl:Class
GO:0033915 biolink:NamedThing mannan 1,2-(1,3)-alpha-mannosidase activity Catalysis of the hydrolysis of (1->2) and (1->3) linkages in mannan, releasing mannose. got7fsn_ti 1,2-1,3-alpha-D-mannan mannohydrolase activity|exo-1,2-1,3-alpha-mannosidase activity EC:3.2.1.77|MetaCyc:3.2.1.77-RXN molecular_function owl:Class
GO:0004559 biolink:NamedThing alpha-mannosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. got7fsn_ti alpha-D-mannoside mannohydrolase activity|1,2-alpha-D-mannosidase activity|1,2-alpha-mannosidase|p-nitrophenyl-alpha-mannosidase activity|alpha-D-mannopyranosidase activity|alpha-D-mannosidase activity|exo-alpha-mannosidase activity Reactome:R-HSA-6799545|EC:3.2.1.24|Reactome:R-HSA-9694656|Reactome:R-HSA-8853686|MetaCyc:3.2.1.24-RXN molecular_function owl:Class
GO:0060066 biolink:NamedThing oviduct development The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. got7fsn_ti Mullerian tract development|fallopian tube development biological_process owl:Class
GO:0072310 biolink:NamedThing glomerular epithelial cell development The process whose specific outcome is the progression of a glomerular epithelial cell over time, from its formation to the mature structure. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. got7fsn_ti mah 2010-04-09T06:47:31Z biological_process owl:Class
GO:0070482 biolink:NamedThing response to oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. got7fsn_ti biological_process owl:Class
GO:0003860 biolink:NamedThing 3-hydroxyisobutyryl-CoA hydrolase activity Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. got7fsn_ti HIB CoA deacylase activity|3-hydroxy-isobutyryl CoA hydrolase activity|3-hydroxy-2-methylpropanoyl-CoA hydrolase activity MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN|EC:3.1.2.4|Reactome:R-HSA-70881|RHEA:20888 molecular_function owl:Class
GO:0004760 biolink:NamedThing serine-pyruvate transaminase activity Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine. got7fsn_ti L-serine:pyruvate aminotransferase activity|hydroxypyruvate:L-alanine transaminase activity|serine-pyruvate aminotransferase, type 2A|serine-pyruvate aminotransferase, type 1|serine-pyruvate aminotransferase, type 2B|serine-pyruvate aminotransferase activity|serine--pyruvate aminotransferase activity|SPT GO:0004761|GO:0004763|GO:0004762 MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN|RHEA:22852|KEGG_REACTION:R00585|EC:2.6.1.51 molecular_function owl:Class
GO:0010371 biolink:NamedThing regulation of gibberellin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins. got7fsn_ti regulation of gibberellic acid biosynthetic process biological_process owl:Class
GO:0052205 biolink:NamedThing modulation of molecular function in other organism involved in symbiotic interaction The process in which an organism effects a change in the function of proteins in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modulation of molecular function in other organism during symbiotic interaction|modification of protein function in other organism during symbiotic interaction|modification of molecular function in other organism during symbiotic interaction biological_process owl:Class
GO:0061220 biolink:NamedThing mesonephric macula densa development The process whose specific outcome is the progression of the mesonephric macula densa over time, from its formation to the mature structure. The mesonephric macula densa is an area of specialized cells in the distal tubule of the mesonephros that makes contact with the vascular pole of the glomerulus. got7fsn_ti dph 2010-08-19T01:11:41Z biological_process owl:Class
GO:0072024 biolink:NamedThing macula densa development The process whose specific outcome is the progression of the macula densa over time, from its formation to the mature structure. The macula densa is an area of specialized cells in the distal tubule that makes contact with the vascular pole of the glomerulus. got7fsn_ti mah 2010-01-25T02:40:15Z biological_process owl:Class
GO:0051430 biolink:NamedThing corticotropin-releasing hormone receptor 1 binding Binding to a corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system. got7fsn_ti CRHR1 binding|type 1 corticotropin releasing factor receptor binding|type 1 corticotropin releasing factor receptor ligand|type 1 corticotropin-releasing factor receptor binding GO:0031743 molecular_function owl:Class
GO:0051429 biolink:NamedThing corticotropin-releasing hormone receptor binding Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. got7fsn_ti corticotropin-releasing factor receptor binding|CRH receptor binding|CRF receptor binding|corticotropin releasing factor receptor ligand|corticotropin releasing factor receptor binding|CRHR binding GO:0031742 molecular_function owl:Class
GO:0008817 biolink:NamedThing cob(I)yrinic acid a,c-diamide adenosyltransferase activity Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin. got7fsn_ti ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity|vitamin B12s adenosyltransferase activity|aquocob(I)alamin vitamin B12s adenosyltransferase activity|ATP:corrinoid adenosyltransferase activity|cob(I)alamin adenosyltransferase activity|CobA|aquacob(I)alamin adenosyltransferase activity|ATP:cob(I)alamin Co-beta-adenosyltransferase activity|ATP:cob(I)alamin cobeta-adenosyltransferase activity EC:2.5.1.17|Reactome:R-HSA-3159253|RHEA:14725|MetaCyc:COBALADENOSYLTRANS-RXN|Reactome:R-HSA-3322125 molecular_function owl:Class
GO:1990932 biolink:NamedThing 5.8S rRNA binding Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA. got7fsn_ti sl 2016-03-14T20:25:41Z molecular_function owl:Class
GO:0031154 biolink:NamedThing culmination involved in sorocarp development The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development. got7fsn_ti culmination during sorocarp development|culmination during fruiting body development|culminant development biological_process owl:Class
GO:0042972 biolink:NamedThing licheninase activity Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds. got7fsn_ti 1,3;1,4-beta-glucan 4-glucanohydrolase activity|1,3-1,4-beta-D-glucan 4-glucanohydrolase activity|1,3;1,4-beta-glucan endohydrolase activity|beta-(1->3), (1->4)-D-glucan 4-glucanohydrolase activity|lichenase activity|mixed linkage beta-glucanase activity|1,3-1,4-beta-glucan 4-glucanohydrolase activity|beta-glucanase activity|endo-beta-1,3-1,4 glucanase activity EC:3.2.1.73|MetaCyc:3.2.1.73-RXN molecular_function owl:Class
GO:0010390 biolink:NamedThing histone monoubiquitination The modification of histones by addition of a single ubiquitin group. got7fsn_ti biological_process owl:Class
GO:0016267 biolink:NamedThing O-glycan processing, core 1 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc. got7fsn_ti biological_process owl:Class
GO:0016266 biolink:NamedThing O-glycan processing The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure. got7fsn_ti biological_process owl:Class
GO:0005092 biolink:NamedThing GDP-dissociation inhibitor activity Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. got7fsn_ti GDI molecular_function owl:Class
GO:0030695 biolink:NamedThing GTPase regulator activity Binds to and modulates the activity of a GTPase. got7fsn_ti small GTPase regulator activity|small GTPase regulatory/interacting protein activity GO:0005083 molecular_function owl:Class
GO:0030757 biolink:NamedThing 3-methylquercitin 7-O-methyltransferase activity Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine. got7fsn_ti flavonol 7-methyltransferase activity|S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity|7-OMT activity|3-methylquercetin 7-O-methyltransferase activity|flavonol 7-O-methyltransferase activity|S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity EC:2.1.1.82|KEGG_REACTION:R05323|MetaCyc:2.1.1.82-RXN|RHEA:16181 molecular_function owl:Class
GO:0044837 biolink:NamedThing actomyosin contractile ring organization A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring. got7fsn_ti cytokinesis, actomyosin contractile ring organization jl 2014-02-26T15:31:31Z biological_process owl:Class
GO:0031032 biolink:NamedThing actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. got7fsn_ti actomyosin organization|actomyosin structure organisation|actomyosin structure organization and biogenesis Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. biological_process owl:Class
GO:0097038 biolink:NamedThing perinuclear endoplasmic reticulum The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. got7fsn_ti perinuclear ER pr 2011-04-12T10:51:05Z cellular_component owl:Class
GO:0005291 biolink:NamedThing high-affinity L-histidine transmembrane transporter activity Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity histidine permease activity|high affinity L-histidine transmembrane transporter activity molecular_function owl:Class
GO:0006277 biolink:NamedThing DNA amplification The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. got7fsn_ti biological_process owl:Class
GO:0018566 biolink:NamedThing 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate. got7fsn_ti 1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity UM-BBD_reactionID:r0324|EC:1.13.11.- molecular_function owl:Class
GO:0019878 biolink:NamedThing lysine biosynthetic process via aminoadipic acid The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway. got7fsn_ti lysine biosynthetic process, aminoadipic acid pathway|lysine biosynthetic process, aminoadipic pathway|lysine biosynthesis, aminoadipic acid pathway|lysine synthesis via aminoadipic acid|lysine anabolism via aminoadipic acid|lysine formation via aminoadipic acid|lysine biosynthesis, aminoadipic pathway biological_process owl:Class
GO:0009085 biolink:NamedThing lysine biosynthetic process The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid. got7fsn_ti lysine biosynthesis|lysine synthesis|lysine formation|lysine anabolism MetaCyc:PWY-5097 biological_process owl:Class
GO:0097682 biolink:NamedThing intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts. got7fsn_ti pr 2014-12-17T16:50:30Z molecular_function owl:Class
GO:0005217 biolink:NamedThing intracellular ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti molecular_function owl:Class
GO:0009852 biolink:NamedThing auxin catabolic process The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth. got7fsn_ti auxin breakdown|auxin degradation|auxin catabolism biological_process owl:Class
GO:0036026 biolink:NamedThing protein C inhibitor-PLAT complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator. got7fsn_ti SERPINA5-PLAT complex|protein C inhibitor-tPA complex|serpin A5-PLAT complex|protein C inhibitor-tissue-type plasminogen activator complex|plasma serine protease inhibitor-PLAT complex|PCI-PLAT complex bf 2011-10-19T01:30:56Z cellular_component owl:Class
GO:0042474 biolink:NamedThing middle ear morphogenesis The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window). got7fsn_ti biological_process owl:Class
GO:0044227 biolink:NamedThing methane-oxidizing organelle A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms. got7fsn_ti methane-oxidizing compartment|methanotroph intracytoplasmic membrane-bound compartment jl 2009-11-17T02:13:52Z cellular_component owl:Class
GO:0061864 biolink:NamedThing basement membrane constituent secretion The controlled release of molecules that form the basement membrane, including carbohydrates and glycoproteins by a cell. got7fsn_ti dph 2017-04-07T18:23:39Z biological_process owl:Class
GO:0070278 biolink:NamedThing extracellular matrix constituent secretion The controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell. got7fsn_ti ECM secretion|ECM constituent secretion biological_process owl:Class
GO:0140444 biolink:NamedThing cytoskeleton-nuclear membrane anchor activity The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane. got7fsn_ti nuclear membrane-cytoskeleton anchor activity|cytoskeleton nuclear membrane anchor activity|cytoskeletal protein-nuclear membrane adaptor activity|cytoskeletal protein-nuclear membrane anchor activity https://github.com/geneontology/go-ontology/issues/18283 pg 2020-03-24T14:57:59Z molecular_function owl:Class
GO:0043495 biolink:NamedThing protein-membrane adaptor activity The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. got7fsn_ti anchoring|protein membrane adaptor|protein membrane anchor|protein membrane adaptor activity https://github.com/geneontology/go-ontology/issues/19090 molecular_function owl:Class
GO:0018221 biolink:NamedThing peptidyl-serine palmitoylation The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine. got7fsn_ti peptidyl-serine O-palmitoylation Palmitoylation of a non-terminal serine residue always occurs on an oxygen (O) atom. RESID:AA0080 biological_process owl:Class
GO:0044826 biolink:NamedThing viral genome integration into host DNA The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses. got7fsn_ti viral genome integration jl 2014-02-04T16:58:43Z biological_process owl:Class
GO:0090461 biolink:NamedThing glutamate homeostasis Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell. got7fsn_ti tb 2012-09-24T14:22:02Z biological_process owl:Class
GO:0097269 biolink:NamedThing all-trans-decaprenyl-diphosphate synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate. got7fsn_ti (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity|2-trans,6-trans-farnesyl diphosphate activity pr 2012-03-20T01:00:23Z RHEA:27802|Reactome:R-HSA-2162253|EC:2.5.1.91 molecular_function owl:Class
GO:0047396 biolink:NamedThing glycosylphosphatidylinositol diacylglycerol-lyase activity Catalysis of the reaction: 6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 1,2-diacyl-sn-glycerol + 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate. got7fsn_ti GPI-PLC activity|GPI-specific phospholipase C activity|glycosylphosphatidylinositol-specific phospholipase C activity|6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) activity|variant-surface-glycoprotein phospholipase C activity|VSG-lipase activity|6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]|glycosylphosphatidylinositol-phospholipase C activity|glycosyl inositol phospholipid anchor-hydrolyzing enzyme activity|(glycosyl)phosphatidylinositol-specific phospholipase C activity MetaCyc:3.1.4.47-RXN|RHEA:14333|EC:4.6.1.14 molecular_function owl:Class
GO:0016849 biolink:NamedThing phosphorus-oxygen lyase activity Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. got7fsn_ti EC:4.6.-.- molecular_function owl:Class
GO:0071046 biolink:NamedThing nuclear polyadenylation-dependent ncRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA. got7fsn_ti nuclear poly(A)-dependent ncRNA catabolic process krc 2009-08-06T02:14:53Z biological_process owl:Class
GO:0102831 biolink:NamedThing stachyose synthase activity Catalysis of the reaction: 2 raffinose <=> stachyose + sucrose. got7fsn_ti MetaCyc:RXN-8287 molecular_function owl:Class
GO:0150002 biolink:NamedThing distal dendrite The dendrite of the dendritic tree that is farthest away from the neuronal cell body (the soma). got7fsn_ti cellular_component owl:Class
GO:0030425 biolink:NamedThing dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. got7fsn_ti NIF_Subcellular:sao1211023249|Wikipedia:Dendrite cellular_component owl:Class
GO:0031320 biolink:NamedThing hexitol dehydrogenase activity Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor. got7fsn_ti molecular_function owl:Class
GO:0007018 biolink:NamedThing microtubule-based movement A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. got7fsn_ti biological_process owl:Class
GO:0042701 biolink:NamedThing progesterone secretion The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta. got7fsn_ti biological_process owl:Class
GO:0046253 biolink:NamedThing anaerobic toluene biosynthetic process The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen. got7fsn_ti anaerobic toluene formation|anaerobic toluene synthesis|anaerobic toluene anabolism|anaerobic toluene biosynthesis This term was reinstated from obsolete. biological_process owl:Class
GO:0018971 biolink:NamedThing anaerobic toluene metabolic process The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen. got7fsn_ti anaerobic toluene metabolism UM-BBD_pathwayID:tol2 biological_process owl:Class
GO:0030981 biolink:NamedThing cortical microtubule cytoskeleton The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0030863 biolink:NamedThing cortical cytoskeleton The portion of the cytoskeleton that lies just beneath the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0044540 biolink:NamedThing L-cystine L-cysteine-lyase (deaminating) Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide. got7fsn_ti jl 2012-03-22T11:33:32Z KEGG_REACTION:R02408|RHEA:24927|EC:4.4.1.1 molecular_function owl:Class
GO:0032584 biolink:NamedThing growth cone membrane The portion of the plasma membrane surrounding a growth cone. got7fsn_ti cellular_component owl:Class
GO:0097215 biolink:NamedThing negative regulation of lysosomal membrane permeability Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. got7fsn_ti negative regulation of lysosome membrane permeability pr 2012-01-12T10:23:42Z biological_process owl:Class
GO:0097213 biolink:NamedThing regulation of lysosomal membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. got7fsn_ti regulation of lysosome membrane permeability pr 2012-01-12T10:19:44Z biological_process owl:Class
GO:0016085 biolink:NamedThing myoinhibitory hormone activity The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction. got7fsn_ti molecular_function owl:Class
GO:0005179 biolink:NamedThing hormone activity The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. got7fsn_ti cAMP generating peptide activity|lipopeptide hormone|peptide hormone|glycopeptide hormone Also consider annotating to 'receptor agonist activity ; GO:0048018'. molecular_function owl:Class
GO:0009885 biolink:NamedThing transmembrane histidine kinase cytokinin receptor activity Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. got7fsn_ti molecular_function owl:Class
GO:0009884 biolink:NamedThing cytokinin receptor activity Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0008906 biolink:NamedThing inosine kinase activity Catalysis of the reaction: ATP + inosine = ADP + IMP. got7fsn_ti ATP:inosine 5'-phosphotransferase activity|inosine kinase (phosphorylating)|inosine-guanosine kinase activity RHEA:21140|EC:2.7.1.73|MetaCyc:INOSINEKIN-RXN molecular_function owl:Class
GO:1990330 biolink:NamedThing IscS-IscU complex A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consisting of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group. got7fsn_ti bhm 2014-03-17T10:08:19Z cellular_component owl:Class
GO:1990228 biolink:NamedThing sulfurtransferase complex A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor). got7fsn_ti sulfur transfer complex|SufE complex|ThiF-ThiS complex|SufE dimer bhm 2013-11-12T09:08:23Z cellular_component owl:Class
GO:0005753 biolink:NamedThing mitochondrial proton-transporting ATP synthase complex A proton-transporting ATP synthase complex found in the mitochondrial membrane. got7fsn_ti mitochondrial respiratory chain complex V GO:0016470 cellular_component owl:Class
GO:0009848 biolink:NamedThing indoleacetic acid biosynthetic process via tryptophan The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan. got7fsn_ti indoleacetic acid synthesis via tryptophan|indoleacetic acid formation via tryptophan|indoleacetic acid anabolism via tryptophan|IAA biosynthetic process via tryptophan MetaCyc:PWY-581 biological_process owl:Class
GO:0009684 biolink:NamedThing indoleacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants. got7fsn_ti indoleacetic acid synthesis|indole-3-acetate biosynthetic process|IAA biosynthetic process|indole-3-acetate biosynthesis|indole-acetic acid biosynthesis|indole-acetic acid biosynthetic process|indoleacetic acid anabolism|indole acetic acid biosynthetic process|indoleacetic acid formation|indole acetic acid biosynthesis|indoleacetic acid biosynthesis biological_process owl:Class
GO:0102638 biolink:NamedThing [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl diphosphate = [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + diphosphoric acid. got7fsn_ti MetaCyc:RXN-15734|EC:2.5.1.105 molecular_function owl:Class
GO:0072501 biolink:NamedThing cellular divalent inorganic anion homeostasis Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell. got7fsn_ti Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular trivalent inorganic anion homeostasis' ; GO:0072502'). mah 2010-12-16T12:53:05Z biological_process owl:Class
GO:0030002 biolink:NamedThing cellular anion homeostasis Any process involved in the maintenance of an internal steady state of anions at the level of a cell. got7fsn_ti biological_process owl:Class
GO:0047834 biolink:NamedThing D-threo-aldose 1-dehydrogenase activity Catalysis of the reaction: a D-threo-aldose + NAD+ = a D-threo-aldono-1,5-lactone + NADH. got7fsn_ti D-threo-aldose:NAD+ 1-oxidoreductase activity|L-fucose (D-arabinose) dehydrogenase activity|(2S,3R)-aldose dehydrogenase activity|dehydrogenase, L-fucose|L-fucose dehydrogenase activity EC:1.1.1.122|RHEA:19645|MetaCyc:D-THREO-ALDOSE-1-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0060840 biolink:NamedThing artery development The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed. got7fsn_ti dph 2009-08-12T10:10:51Z biological_process owl:Class
GO:0001568 biolink:NamedThing blood vessel development The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. got7fsn_ti biological_process owl:Class
GO:0010783 biolink:NamedThing proboscis morphogenesis, eye-antennal disc-derived The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized. got7fsn_ti biological_process owl:Class
GO:0047537 biolink:NamedThing 2-aminohexanoate transaminase activity Catalysis of the reaction: L-2-aminohexanoate + 2-oxoglutarate = 2-oxohexanoate + L-glutamate. got7fsn_ti norleucine transaminase activity|2-aminohexanoate aminotransferase activity|norleucine aminotransferase activity|norleucine (leucine) aminotransferase activity|L-2-aminohexanoate:2-oxoglutarate aminotransferase activity|leucine L-norleucine: 2-oxoglutarate aminotransferase activity EC:2.6.1.67|MetaCyc:2-AMINOHEXANOATE-AMINOTRANSFERASE-RXN|RHEA:23600 molecular_function owl:Class
GO:0000093 biolink:NamedThing mitotic telophase The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0051326 biolink:NamedThing telophase The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. got7fsn_ti note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Telophase biological_process owl:Class
GO:0033173 biolink:NamedThing calcineurin-NFAT signaling cascade Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). got7fsn_ti calcineurin-NFAT signalling pathway|calcineurin-NFAT signaling pathway biological_process owl:Class
GO:0097720 biolink:NamedThing calcineurin-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. got7fsn_ti calcineurin-mediated signalling|calcineurin signaling pr 2016-08-25T15:22:21Z biological_process owl:Class
GO:0035514 biolink:NamedThing DNA demethylase activity Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule. got7fsn_ti bf 2010-04-30T02:36:43Z molecular_function owl:Class
GO:0060926 biolink:NamedThing cardiac pacemaker cell development The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. got7fsn_ti pacemaker cell development dph 2009-09-29T11:51:55Z biological_process owl:Class
GO:0090630 biolink:NamedThing activation of GTPase activity Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. got7fsn_ti Rab GTPase activation|Ran GTPase activation|Rho GTPase activation|Ral GTPase activation|Rap GTPase activation|Cdc42 GTPase activation|activation of Cdc42 GTPase activity|activation of Ran GTPase activity|activation of Rho GTPase activity|Ras GTPase activation|Rac GTPase activation|activation of Rab GTPase activity|activation of Ral GTPase activity|activation of ARF GTPase activity|ARF GTPase activation|activation of Ras GTPase activity|activation of Rap GTPase activity|activation of Rac GTPase activity tb 2015-02-11T16:09:19Z GO:0032856|GO:0032861|GO:0032860|GO:0032857|GO:0032859|GO:0032863|GO:0032864|GO:0032858|GO:0032862 biological_process owl:Class
GO:0043547 biolink:NamedThing positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase. got7fsn_ti positive regulation of Ral GTPase activity|up regulation of Rho GTPase activity|upregulation of Rho GTPase activity|stimulation of Ran GTPase activity|stimulation of Ras GTPase activity|up-regulation of Rho GTPase activity|up-regulation of Rap GTPase activity|stimulation of ARF GTPase activity|upregulation of Ran GTPase activity|positive regulation of Rap GTPase activity|upregulation of Cdc42 GTPase activity|up regulation of GTPase activity|stimulation of Rab GTPase activity|up-regulation of GTPase activity|stimulation of Cdc42 GTPase activity|stimulation of GTPase activity|positive regulation of Ras GTPase activity|stimulation of Rac GTPase activity|up regulation of Ras GTPase activity|up regulation of Ral GTPase activity|stimulation of Ral GTPase activity|stimulation of Rho GTPase activity|activation of GTPase activity|up-regulation of Cdc42 GTPase activity|upregulation of Rap GTPase activity|upregulation of ARF GTPase activity|up regulation of Ran GTPase activity|up regulation of Rac GTPase activity|up-regulation of Ras GTPase activity|stimulation of Rap GTPase activity|up-regulation of ARF GTPase activity|upregulation of Rac GTPase activity|up-regulation of Rab GTPase activity|up-regulation of Ran GTPase activity|up regulation of Cdc42 GTPase activity|up regulation of Rab GTPase activity|positive regulation of Rac GTPase activity|upregulation of GTPase activity|up regulation of Rap GTPase activity|upregulation of Ral GTPase activity|upregulation of Ras GTPase activity|up-regulation of Ral GTPase activity|positive regulation of Rab GTPase activity|positive regulation of ARF GTPase activity|positive regulation of Rho GTPase activity|positive regulation of Cdc42 GTPase activity|up regulation of ARF GTPase activity|positive regulation of Ran GTPase activity|up-regulation of Rac GTPase activity|upregulation of Rab GTPase activity GO:0032854|GO:0032851|GO:0032320|GO:0032321|GO:0032850|GO:0032852|GO:0032853|GO:0032855|GO:0043089 biological_process owl:Class
GO:0030697 biolink:NamedThing S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes. got7fsn_ti ribothymidyl synthase activity|tRNA (uracil-5-)-methyltransferase activity|transfer RNA uracil methylase activity|transfer RNA uracil 5-methyltransferase activity|S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity|RUMT|tRNA uracil 5-methyltransferase activity|RUMT activity|M5U-methyltransferase activity|tRNA:m(5)U54-methyltransferase activity|S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity|tRNA:m5U54-methyltransferase activity GO:0009021 EC:2.1.1.35|RHEA:42712|MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0022030 biolink:NamedThing telencephalon glial cell migration The orderly movement of glial cells through the telencephalon. got7fsn_ti biological_process owl:Class
GO:0022029 biolink:NamedThing telencephalon cell migration The orderly movement of a cell from one site to another at least one of which is located in the telencephalon. got7fsn_ti biological_process owl:Class
GO:0048161 biolink:NamedThing double layer follicle stage The stage in oogenesis when a double layer of distinct follicle cells surrounds the oocyte. An example of this process is found in Mus musculus. got7fsn_ti mammalian oogenesis stage 4 biological_process owl:Class
GO:1900816 biolink:NamedThing ochratoxin A metabolic process The chemical reactions and pathways involving ochratoxin A. got7fsn_ti Ochratoxin A metabolic process|Ochratoxin A metabolism di 2012-06-04T10:13:02Z biological_process owl:Class
GO:0019937 biolink:NamedThing protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid. got7fsn_ti RESID:AA0294 biological_process owl:Class
GO:0018419 biolink:NamedThing protein catenane formation The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain. got7fsn_ti biological_process owl:Class
GO:0071221 biolink:NamedThing cellular response to bacterial lipopeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus. got7fsn_ti mah 2009-12-03T01:28:03Z biological_process owl:Class
GO:0070339 biolink:NamedThing response to bacterial lipopeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipopeptide stimulus. got7fsn_ti biological_process owl:Class
GO:0060090 biolink:NamedThing molecular adaptor activity The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. got7fsn_ti protein-containing complex scaffold activity|protein complex scaffold activity|binding, bridging GO:0032947 molecular_function owl:Class
GO:0019979 biolink:NamedThing interleukin-4 binding Binding to interleukin-4. got7fsn_ti IL-4 binding molecular_function owl:Class
GO:0005596 biolink:NamedThing collagen type XIV trimer A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures. got7fsn_ti cellular_component owl:Class
GO:0031124 biolink:NamedThing mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule. got7fsn_ti mRNA 3' end processing biological_process owl:Class
GO:0006397 biolink:NamedThing mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. got7fsn_ti mRNA maturation biological_process owl:Class
GO:0072729 biolink:NamedThing cellular response to Gentian violet Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus. got7fsn_ti cellular response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride|cellular response to crystal violet mah 2012-05-31T11:23:40Z biological_process owl:Class
GO:0072728 biolink:NamedThing response to Gentian violet Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus. got7fsn_ti response to crystal violet|response to {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride mah 2012-05-31T11:23:25Z biological_process owl:Class
GO:0042380 biolink:NamedThing hydroxymethylbutenyl pyrophosphate reductase activity Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate. got7fsn_ti (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming) molecular_function owl:Class
GO:0035294 biolink:NamedThing determination of wing disc primordium Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc. got7fsn_ti biological_process owl:Class
GO:0007445 biolink:NamedThing determination of imaginal disc primordium Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment. got7fsn_ti biological_process owl:Class
GO:0044405 biolink:NamedThing detection of host The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti recognition of host biological_process owl:Class
GO:0001831 biolink:NamedThing trophectodermal cellular morphogenesis The morphogenesis of trophectoderm cells. got7fsn_ti trophectoderm cellular morphogenesis See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. biological_process owl:Class
GO:0032350 biolink:NamedThing regulation of hormone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone. got7fsn_ti regulation of hormone metabolism biological_process owl:Class
GO:0019222 biolink:NamedThing regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. got7fsn_ti regulation of organismal metabolic process|regulation of multicellular organismal metabolic process|regulation of metabolism GO:0044246 biological_process owl:Class
GO:0102398 biolink:NamedThing dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+. got7fsn_ti MetaCyc:RXN-13657 molecular_function owl:Class
GO:0010115 biolink:NamedThing regulation of abscisic acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid. got7fsn_ti regulation of abscisic acid formation|regulation of abscisic acid synthesis|regulation of abscisic acid biosynthesis|regulation of abscisic acid anabolism biological_process owl:Class
GO:0043455 biolink:NamedThing regulation of secondary metabolic process Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. got7fsn_ti regulation of secondary metabolism biological_process owl:Class
GO:0036222 biolink:NamedThing XTP diphosphatase activity Catalysis of the reaction: XTP + H2O <=> H+ + XDP + monophosphate. got7fsn_ti XTP pyrophosphohydrolase activity|XTP/dITP diphosphatase|XTPase activity|hypoxanthine/xanthine dNTP pyrophosphatase https://github.com/geneontology/go-ontology/issues/19078 While XTP is not produced by cells, deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP, XTP, and dXTP. XTPase contributes to the removal of these abnormal bases from the cellular pool of nucleotide triphosphates. bf 2012-05-08T01:47:59Z GO:0103024 RHEA:28610|KEGG_REACTION:R02720|MetaCyc:RXN0-1603|Reactome:R-HSA-2509831|MetaCyc:RXN0-5074|EC:3.6.1.66 molecular_function owl:Class
GO:0048848 biolink:NamedThing neurohypophysis morphogenesis The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. got7fsn_ti posterior pituitary morphogenesis|neurophysis morphogenesis|posterior pituitary gland morphogenesis biological_process owl:Class
GO:0001400 biolink:NamedThing mating projection base The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone. got7fsn_ti conjugation tube base|base of shmoo tip cellular_component owl:Class
GO:0035162 biolink:NamedThing embryonic hemopoiesis The stages of blood cell formation that take place within the embryo. got7fsn_ti embryonic haemopoiesis|embryonic hematopoiesis|embryonic haematopoiesis biological_process owl:Class
GO:0030097 biolink:NamedThing hemopoiesis The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. got7fsn_ti blood cell biosynthesis|haemopoiesis|hematopoiesis|blood cell formation Wikipedia:Haematopoiesis biological_process owl:Class
GO:0001101 biolink:NamedThing response to acid chemical Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. got7fsn_ti response to acid anion|response to acid|response to oxoanion This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. biological_process owl:Class
GO:0019864 biolink:NamedThing IgG binding Binding to an immunoglobulin of an IgG isotype. got7fsn_ti molecular_function owl:Class
GO:0045458 biolink:NamedThing recombination within rDNA repeats Genetic recombination within the DNA of the genes coding for ribosomal RNA. got7fsn_ti recombination within ribosomal DNA repeats Note that this term was reinstated from obsolete. biological_process owl:Class
GO:0047972 biolink:NamedThing guanidinopropionase activity Catalysis of the reaction: 3-guanidinopropanoate + H(2)O = beta-alanine + urea. got7fsn_ti GPase activity|GPH|3-guanidinopropanoate amidinopropionase activity EC:3.5.3.17|KEGG_REACTION:R00913|MetaCyc:GUANIDINOPROPIONASE-RXN|RHEA:16029 molecular_function owl:Class
GO:0097030 biolink:NamedThing CENP-A containing nucleosome binding Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). got7fsn_ti centromere-specific nucleosome binding|centromeric nucleosome binding pr 2011-04-01T03:19:35Z molecular_function owl:Class
GO:0045311 biolink:NamedThing invasive growth in response to pheromone The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus. got7fsn_ti biological_process owl:Class
GO:0036267 biolink:NamedThing invasive filamentous growth The growth of colonies in filamentous chains of cells into a substrate. got7fsn_ti invasive growth bf 2012-07-02T01:42:24Z biological_process owl:Class
GO:0010700 biolink:NamedThing negative regulation of norepinephrine secretion Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine. got7fsn_ti biological_process owl:Class
GO:0014061 biolink:NamedThing regulation of norepinephrine secretion Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. got7fsn_ti regulation of noradrenaline secretion biological_process owl:Class
GO:0044505 biolink:NamedThing positive regulation of G protein-coupled receptor activity in other organism A process that activates or increases the frequency, rate or extent of the activity of a G protein-coupled receptor in a second organism. got7fsn_ti positive regulation of G-protein coupled receptor activity in other organism|regulation of G-protein coupled receptor activity in other organism jl 2012-02-23T04:24:17Z biological_process owl:Class
GO:0097446 biolink:NamedThing protein localization to eisosome filament A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1. got7fsn_ti protein localization to linear eisosome pr 2012-12-17T09:37:49Z biological_process owl:Class
GO:0044380 biolink:NamedThing protein localization to cytoskeleton A process in which a protein is transported to, or maintained in, a location within the cytoskeleton. got7fsn_ti protein localisation to cytoskeleton jl 2011-12-13T11:43:24Z biological_process owl:Class
GO:0033894 biolink:NamedThing ribonuclease P4 activity Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor. got7fsn_ti EC:3.1.26.7|MetaCyc:3.1.26.7-RXN molecular_function owl:Class
GO:0046862 biolink:NamedThing chromoplast membrane Either of the lipid bilayers that surround a chromoplast and form the chromoplast envelope. got7fsn_ti cellular_component owl:Class
GO:0008398 biolink:NamedThing sterol 14-demethylase activity Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O. got7fsn_ti sterol 14-alpha-demethylase activity|cytochrome P450 CYP51|sterol 14alpha-demethylase activity|lanosterol 14-alpha-demethylase activity|sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)|lanosterol 14alpha-demethylase activity|obtusufoliol 14-demethylase activity|lanosterol 14-demethylase activity|cytochrome P450 51 activity MetaCyc:1.14.13.70-RXN|RHEA:14917|EC:1.14.13.70|Reactome:R-HSA-194678 molecular_function owl:Class
GO:0052927 biolink:NamedThing CTP:tRNA cytidylyltransferase activity Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3' cytidine end + diphosphate. got7fsn_ti KEGG_REACTION:R09383|EC:2.7.7.72 molecular_function owl:Class
GO:0070503 biolink:NamedThing selenium-containing prosthetic group metabolic process The chemical reactions and pathways involving a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments. got7fsn_ti selenium-containing prosthetic group metabolism biological_process owl:Class
GO:0033930 biolink:NamedThing keratan-sulfate endo-1,4-beta-galactosidase activity Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in keratan sulfate. got7fsn_ti keratan-sulfate 1,4-beta-D-galactanohydrolase activity|keratanase activity|keratan sulfate endogalactosidase activity|endo-beta-galactosidase activity EC:3.2.1.103|MetaCyc:3.2.1.103-RXN molecular_function owl:Class
GO:0015925 biolink:NamedThing galactosidase activity Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. got7fsn_ti molecular_function owl:Class
GO:0043836 biolink:NamedThing xanthine hydrolase activity Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate. got7fsn_ti xanthinase activity MetaCyc:R127-RXN molecular_function owl:Class
GO:0016316 biolink:NamedThing phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate. got7fsn_ti inositol polyphosphate 4-phosphatase type II activity|1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity GO:0004440 Reactome:R-HSA-1676164|Reactome:R-HSA-1676162|EC:3.1.3.66|MetaCyc:3.1.3.66-RXN molecular_function owl:Class
GO:0061414 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. got7fsn_ti dph 2012-01-23T11:31:27Z biological_process owl:Class
GO:0000436 biolink:NamedThing carbon catabolite activation of transcription from RNA polymerase II promoter Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter by carbon catabolites biological_process owl:Class
GO:0050913 biolink:NamedThing sensory perception of bitter taste The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti bitter taste perception biological_process owl:Class
GO:0050909 biolink:NamedThing sensory perception of taste The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process. got7fsn_ti sense of taste|gustation|taste perception|taste Wikipedia:Taste biological_process owl:Class
GO:0034061 biolink:NamedThing DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. got7fsn_ti DNA nucleotidyltransferase activity|deoxynucleate polymerase activity|deoxyribonucleate nucleotidyltransferase activity|deoxyribonucleic acid polymerase activity|deoxyribonucleic polymerase activity molecular_function owl:Class
GO:0020035 biolink:NamedThing cytoadherence to microvasculature, mediated by symbiont protein The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte. got7fsn_ti parasite-protein-mediated cytoadherence to microvasculature|symbiont-protein-mediated cytoadherence to microvasculature|heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein|cytoadherence to microvasculature, mediated by parasite protein https://github.com/geneontology/go-ontology/issues/18814 GO:0043706 biological_process owl:Class
GO:0044406 biolink:NamedThing adhesion of symbiont to host The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti adhesion to other organism during symbiotic interaction|adhesion to symbiont|adhesion to other organism involved in symbiotic interaction|adhesion to host|host adhesion This term can be used to annotate both symbiont and host organisms. Consider also annotating to biological process involved in interaction with symbiont ; GO:0051702. GO:0051856|GO:0051825 biological_process owl:Class
GO:0048495 biolink:NamedThing Roundabout binding Binding to Roundabout (ROBO) receptor, a transmembrane receptor. got7fsn_ti Roundabout receptor binding molecular_function owl:Class
GO:0039701 biolink:NamedThing microtubule-dependent intracellular transport of viral material towards cell periphery The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane. got7fsn_ti bf 2013-11-06T16:09:57Z VZ:1816 biological_process owl:Class
GO:0075519 biolink:NamedThing microtubule-dependent intracellular transport of viral material The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus. got7fsn_ti jl 2011-08-03T01:45:25Z biological_process owl:Class
GO:0045764 biolink:NamedThing positive regulation of cellular amino acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid. got7fsn_ti up regulation of amino acid metabolic process|upregulation of amino acid metabolic process|stimulation of amino acid metabolic process|up-regulation of amino acid metabolic process|activation of amino acid metabolic process|positive regulation of amino acid metabolism biological_process owl:Class
GO:0006521 biolink:NamedThing regulation of cellular amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids. got7fsn_ti regulation of amino acid metabolism biological_process owl:Class
GO:0060848 biolink:NamedThing endothelial cell fate determination A process involved in cell fate commitment of an endothelial cell. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. got7fsn_ti dph 2009-08-12T11:11:14Z biological_process owl:Class
GO:0008626 biolink:NamedThing granzyme-mediated apoptotic signaling pathway A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells. got7fsn_ti apoptotic signaling pathway in response to granzyme|induction of apoptosis by granzyme http://wiki.geneontology.org/index.php/Apoptosis_Curation_Manual#Other_children_of_apoptotic_signaling_pathway biological_process owl:Class
GO:0097190 biolink:NamedThing apoptotic signaling pathway A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. got7fsn_ti apoptotic signalling pathway|induction of apoptosis by extracellular signals This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways. pr 2011-11-23T09:30:23Z GO:0008624 biological_process owl:Class
GO:0150014 biolink:NamedThing apical distal dendrite Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma). got7fsn_ti bc 2017-12-21T12:03:28Z cellular_component owl:Class
GO:0097440 biolink:NamedThing apical dendrite A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. got7fsn_ti pr 2012-12-06T13:45:18Z NIF_Subcellular:sao273773228 cellular_component owl:Class
GO:1905605 biolink:NamedThing positive regulation of blood-brain barrier permeability Any process that increases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. got7fsn_ti up-regulation of blood-brain barrier permeability|activation of maintenance of permeability of blood-brain barrier|positive regulation of blood/brain barrier permeability|positive regulation of BBB permeability|up-regulation of blood/brain barrier permeability|activation of maintenance of permeability of BBB|upregulation of blood-brain barrier permeability|upregulation of blood/brain barrier permeability|upregulation of BBB permeability|up-regulation of BBB permeability als 2016-10-26T13:18:32Z biological_process owl:Class
GO:1905603 biolink:NamedThing regulation of blood-brain barrier permeability Any process that modulates blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. got7fsn_ti regulation of blood/brain barrier permeability|regulation of BBB permeability als 2016-10-26T13:18:16Z biological_process owl:Class
GO:0097418 biolink:NamedThing neurofibrillary tangle Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. got7fsn_ti star-shaped neurofibrillary tangle|flame-shaped neurofibrillary tangle Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267). pr 2012-11-06T16:49:35Z NIF_Subcellular:nlx_subcell_20090202|NIF_Subcellular:nlx_subcell_20090201|NIF_Subcellular:sao2409833926 cellular_component owl:Class
GO:0035118 biolink:NamedThing embryonic pectoral fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. got7fsn_ti biological_process owl:Class
GO:0035138 biolink:NamedThing pectoral fin morphogenesis The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. got7fsn_ti biological_process owl:Class
GO:0004124 biolink:NamedThing cysteine synthase activity Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate. got7fsn_ti OAS sulfhydrylase activity|O-acetylserine sulfhydrylase activity|O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity|3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity|O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity|O-acetyl-L-serine sulfohydrolase activity|O-acetylserine (thiol)-lyase activity|acetylserine sulfhydrylase activity|O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)|O-acetylserine (thiol)-lyase A activity|cysteine synthetase activity|O-acetyl-L-serine sulfhydrylase activity Note that this function was formerly 4.2.99.8. EC:2.5.1.47|MetaCyc:ACSERLY-RXN|RHEA:14829 molecular_function owl:Class
GO:0039635 biolink:NamedThing suppression by virus of host peptidoglycan biosynthetic process Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls. got7fsn_ti viral inhibition of host peptidoglycan biosynthesis bf 2012-08-10T14:58:12Z biological_process owl:Class
GO:0039636 biolink:NamedThing suppression by virus of host cell wall biogenesis Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts. got7fsn_ti bf 2012-08-10T15:04:12Z biological_process owl:Class
GO:0010189 biolink:NamedThing vitamin E biosynthetic process The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. got7fsn_ti alpha-tocopherol biosynthetic process|alpha-tocopherol biosynthesis|vitamin E synthesis|vitamin E biosynthesis|tocopherol biosynthetic process|vitamin E formation|tocopherol biosynthesis|vitamin E anabolism MetaCyc:PWY-1422 biological_process owl:Class
GO:0042362 biolink:NamedThing fat-soluble vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. got7fsn_ti fat-soluble vitamin biosynthesis|fat-soluble vitamin synthesis|fat-soluble vitamin formation|fat-soluble vitamin anabolism biological_process owl:Class
GO:0020009 biolink:NamedThing microneme A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell. got7fsn_ti sarconeme Wikipedia:Microneme cellular_component owl:Class
GO:0022858 biolink:NamedThing alanine transmembrane transporter activity Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. got7fsn_ti molecular_function owl:Class
GO:0051478 biolink:NamedThing mannosylglycerate metabolic process The chemical reactions and pathways involving mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. got7fsn_ti mannosylglycerate metabolism biological_process owl:Class
GO:0102087 biolink:NamedThing N-benzoyl-L-glutamate synthetase activity Catalysis of the reaction: benzoate + L-glutamate + ATP <=> H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10886 molecular_function owl:Class
GO:0034719 biolink:NamedThing SMN-Sm protein complex A protein complex formed by the association of several methylated Sm proteins with the SMN complex; the latter contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and unrip proteins; additional proteins, including galectin-1 and galectin-3, are also found in the SMN-SM complex. The SMN-Sm complex is involved in spliceosomal snRNP assembly in the cytoplasm. got7fsn_ti SMN-containing protein complex Note that this complex is sometimes referred to as the 'SMN complex', but it should not be confused with GO:0032797. cellular_component owl:Class
GO:0102938 biolink:NamedThing orcinol O-methyltransferase activity Catalysis of the reaction: orcinol + S-adenosyl-L-methionine = H+ + 3-methoxy-5-hydroxytoluene + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-9017|EC:2.1.1.6 molecular_function owl:Class
GO:1990276 biolink:NamedThing RNA 5'-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule. got7fsn_ti pr 2014-01-28T09:44:16Z molecular_function owl:Class
GO:0043401 biolink:NamedThing steroid hormone mediated signaling pathway A series of molecular signals mediated by a steroid hormone binding to a receptor. got7fsn_ti steroid hormone mediated signalling biological_process owl:Class
GO:0018959 biolink:NamedThing aerobic phenol-containing compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. got7fsn_ti aerobic phenol-containing compound metabolism UM-BBD_pathwayID:pba biological_process owl:Class
GO:0005010 biolink:NamedThing insulin-like growth factor-activated receptor activity Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti IGF receptor activity|insulin-like growth factor receptor activity|IGF-activated receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class
GO:0097326 biolink:NamedThing melanocyte adhesion The attachment of a melanocyte to another cell via adhesion molecules. got7fsn_ti pr 2012-06-08T10:12:03Z biological_process owl:Class
GO:0044107 biolink:NamedThing cellular alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells. got7fsn_ti jl 2009-07-15T01:36:19Z biological_process owl:Class
GO:0033966 biolink:NamedThing N-substituted formamide deformylase activity Catalysis of the reaction: N-benzylformamide + H2O = formate + benzylamine. got7fsn_ti NfdA|N-benzylformamide amidohydrolase activity MetaCyc:3.5.1.91-RXN|RHEA:12096 molecular_function owl:Class
GO:0047321 biolink:NamedThing diphosphate-protein phosphotransferase activity Catalysis of the reaction: microsomal-membrane protein + diphosphate = diphosphate + O-phospho-microsomal-membrane protein. got7fsn_ti diphosphate:microsomal-membrane-protein O-phosphotransferase activity|triphosphate:microsomal-membrane-protein phosphotransferase activity|pyrophosphate:protein phosphotransferase activity|triphosphate-protein phosphotransferase activity|pyrophosphate-protein phosphotransferase activity|DiPPT EC:2.7.99.1|MetaCyc:2.7.99.1-RXN molecular_function owl:Class
GO:0032581 biolink:NamedThing ER-dependent peroxisome organization A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum. got7fsn_ti endoplasmic reticulum-dependent peroxisome organization|ER-dependent peroxisome organisation|ER-dependent peroxisome biogenesis biological_process owl:Class
GO:0007031 biolink:NamedThing peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. got7fsn_ti peroxisome-assembly ATPase activity|peroxisome organization and biogenesis|peroxisome organisation biological_process owl:Class
GO:0048737 biolink:NamedThing imaginal disc-derived appendage development The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism. got7fsn_ti biological_process owl:Class
GO:0048736 biolink:NamedThing appendage development The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. got7fsn_ti biological_process owl:Class
GO:0014895 biolink:NamedThing smooth muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy. got7fsn_ti biological_process owl:Class
GO:0014896 biolink:NamedThing muscle hypertrophy The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy. got7fsn_ti Wikipedia:Muscle_hypertrophy biological_process owl:Class
GO:0106378 biolink:NamedThing 2-hydroxy-dATP hydrolase activity Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + diphosphate. got7fsn_ti hjd 2021-04-23T00:14:20Z RHEA:31583 molecular_function owl:Class
GO:0017157 biolink:NamedThing regulation of exocytosis Any process that modulates the frequency, rate or extent of exocytosis. got7fsn_ti biological_process owl:Class
GO:0044537 biolink:NamedThing regulation of circulating fibrinogen levels Any process that modulates the quantity of fibrinogen circulating in the bloodstream. got7fsn_ti jl 2012-03-21T03:15:09Z biological_process owl:Class
GO:0071453 biolink:NamedThing cellular response to oxygen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. got7fsn_ti cellular response to oxygen mah 2009-12-16T04:43:59Z biological_process owl:Class
GO:0097397 biolink:NamedThing cellular response to interleukin-32 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus. got7fsn_ti cellular response to IL-32 pr 2012-10-23T13:23:22Z biological_process owl:Class
GO:0009760 biolink:NamedThing C4 photosynthesis The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch. got7fsn_ti Wikipedia:C4_carbon_fixation biological_process owl:Class
GO:0015977 biolink:NamedThing carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). got7fsn_ti autotrophic CO2 fixation|autotrophic CO2 fixation pathway|carbon dioxide fixation|autotrophy Wikipedia:Carbon_fixation biological_process owl:Class
GO:0030662 biolink:NamedThing coated vesicle membrane The lipid bilayer surrounding a coated vesicle. got7fsn_ti cellular_component owl:Class
GO:0070840 biolink:NamedThing dynein complex binding Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. got7fsn_ti dynein binding mah 2009-07-31T01:22:47Z GO:0045502 molecular_function owl:Class
GO:0034944 biolink:NamedThing 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+. got7fsn_ti UM-BBD_reactionID:r0986 molecular_function owl:Class
GO:0050496 biolink:NamedThing peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide. got7fsn_ti peptidyl-L-glutamyl 5-omega-hydroxyceramide ester anabolism from peptidyl-glutamine|peptidyl-L-glutamyl 5-omega-hydroxyceramide ester formation from peptidyl-glutamine|peptidyl-L-glutamyl 5-omega-hydroxyceramide ester synthesis from peptidyl-glutamine RESID:AA0340 biological_process owl:Class
GO:0007000 biolink:NamedThing nucleolus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus. got7fsn_ti nucleolus organisation|nucleolus organization and biogenesis biological_process owl:Class
GO:0006997 biolink:NamedThing nucleus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. got7fsn_ti nucleus organization and biogenesis|nuclear organization|nuclear organisation|nuclear morphology|nuclear organization and biogenesis GO:0048287 biological_process owl:Class
GO:0004316 biolink:NamedThing 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. got7fsn_ti 3-oxoacyl-[acyl-carrier protein] reductase activity|beta-ketoacyl-acyl-carrier protein(ACP) reductase activity|(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity|NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity|beta-ketoacyl acyl carrier protein (ACP) reductase activity|3-ketoacyl acyl carrier protein reductase activity|beta-ketoacyl-acyl carrier protein reductase activity|beta-ketoacyl thioester reductase activity|3-oxoacyl-ACPreductase activity|beta-ketoacyl reductase activity|3-oxoacyl-ACP reductase activity|beta-ketoacyl-ACP reductase activity|3-oxoacyl-acyl-carrier-protein reductase activity https://github.com/geneontology/go-ontology/issues/21876 MetaCyc:RXN-11476|MetaCyc:RXN-10659|RHEA:17397|EC:1.1.1.100|MetaCyc:RXN-11480|MetaCyc:3-OXOACYL-ACP-REDUCT-RXN|Reactome:R-HSA-8862152 molecular_function owl:Class
GO:0030114 biolink:NamedThing slime layer A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids. got7fsn_ti Wikipedia:Slime_layer cellular_component owl:Class
GO:0030112 biolink:NamedThing glycocalyx A carbohydrate rich layer at the outermost periphery of a cell. got7fsn_ti Wikipedia:Glycocalyx cellular_component owl:Class
GO:0032866 biolink:NamedThing D-xylose:NADP reductase activity Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+. got7fsn_ti D-xylose reductase activity|xylose reductase activity MetaCyc:RXN-8773|RHEA:27445 molecular_function owl:Class
GO:0004032 biolink:NamedThing alditol:NADP+ 1-oxidoreductase activity Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. got7fsn_ti polyol dehydrogenase (NADP(+)) activity|aldose reductase activity|aldehyde reductase activity KEGG_REACTION:R02820|MetaCyc:ALDEHYDE-REDUCTASE-RXN|RHEA:12789|EC:1.1.1.21|Reactome:R-HSA-5652172|Reactome:R-HSA-196060 molecular_function owl:Class
GO:0021631 biolink:NamedThing optic nerve morphogenesis The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. got7fsn_ti CN II morphogenesis biological_process owl:Class
GO:0052614 biolink:NamedThing uracil oxygenase activity Catalysis of the reaction: uracil + NADH + O2 + H+ = ureidoacrylate peracid + NAD+. Ureidoacrylate peracid is spontaneously reduced by NADH to form ureidoacrylate. got7fsn_ti pyrimidine oxygenase activity 2010-08-26T10:11:11Z MetaCyc:RXN0-6444|RHEA:31587 molecular_function owl:Class
GO:0120104 biolink:NamedThing mitotic actomyosin contractile ring, proximal layer The region of the mitotic actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located. got7fsn_ti actomyosin contractile ring, proximal layer krc 2017-10-11T22:49:58Z cellular_component owl:Class
GO:0097241 biolink:NamedThing hematopoietic stem cell migration to bone marrow The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. got7fsn_ti progenitor cell homing|hematopoietic stem cell homing|hemopoietic stem cell migration to bone marrow pr 2012-02-09T01:08:32Z biological_process owl:Class
GO:0035701 biolink:NamedThing hematopoietic stem cell migration The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. got7fsn_ti hemopoietic stem cell migration bf 2011-02-28T03:20:36Z biological_process owl:Class
GO:0016896 biolink:NamedThing exoribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. got7fsn_ti exoribonuclease activity, producing 5' phosphomonoesters EC:3.1.13.-|Reactome:R-HSA-429860 molecular_function owl:Class
GO:0005025 biolink:NamedThing transforming growth factor beta receptor activity, type I Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. got7fsn_ti type I transforming growth factor beta receptor activity|type I TGFbeta receptor activity|type I TGF-beta receptor activity|transforming growth factor beta ligand binding to type I receptor molecular_function owl:Class
GO:0034666 biolink:NamedThing integrin alpha2-beta1 complex An integrin complex that comprises one alpha2 subunit and one beta1 subunit. got7fsn_ti ITGA2-ITGB1 complex|VLA-2 complex cellular_component owl:Class
GO:0140647 biolink:NamedThing P450-containing electron transport chain A electron transport chain in which one or more electron carriers operate to transfer electrons from donors to a cytochrome P450 protein or domain. Electron carriers operating in this chain include FAD-containing flavoproteins or domains, FMN domains, ferredoxins and cytochrome b5. The reduced cytochrome P450 functions as the terminal oxidase and participates in a wide range of biochemical pathways. got7fsn_ti P450-containing system https://github.com/geneontology/go-ontology/issues/21455 pg 2021-05-21T08:34:01Z Wikipedia:P450-containing_systems biological_process owl:Class
GO:0022900 biolink:NamedThing electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21455 Wikipedia:Electron_transport_chain biological_process owl:Class
GO:0045067 biolink:NamedThing positive extrathymic T cell selection The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. got7fsn_ti positive extrathymic T-cell selection|positive extrathymic T cell selection|positive extrathymic T lymphocyte selection|positive extrathymic T-lymphocyte selection biological_process owl:Class
GO:0043368 biolink:NamedThing positive T cell selection The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death. got7fsn_ti positive T lymphocyte selection|positive T-cell selection|positive T-lymphocyte selection biological_process owl:Class
GO:0005134 biolink:NamedThing interleukin-2 receptor binding Binding to an interleukin-2 receptor. got7fsn_ti IL-2|interleukin-2 receptor ligand molecular_function owl:Class
GO:0019215 biolink:NamedThing intermediate filament binding Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. got7fsn_ti molecular_function owl:Class
GO:0008016 biolink:NamedThing regulation of heart contraction Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. got7fsn_ti regulation of cardiac contraction biological_process owl:Class
GO:1903522 biolink:NamedThing regulation of blood circulation Any process that modulates the frequency, rate or extent of blood circulation. got7fsn_ti regulation of hemolymph circulation mr 2014-10-06T18:38:56Z biological_process owl:Class
GO:0045174 biolink:NamedThing glutathione dehydrogenase (ascorbate) activity Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide. got7fsn_ti dehydroascorbate reductase activity|dehydroascorbic acid reductase activity|GDOR|glutathione:dehydroascorbate oxidoreductase activity|DHA reductase activity|glutathione dehydroascorbate reductase activity|dehydroascorbic reductase activity|glutathione:dehydroascorbic acid oxidoreductase activity KEGG_REACTION:R01108|EC:1.8.5.1|MetaCyc:1.8.5.1-RXN|Reactome:R-HSA-198813|RHEA:24424 molecular_function owl:Class
GO:0015038 biolink:NamedThing glutathione disulfide oxidoreductase activity Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. got7fsn_ti glutathione disulphide oxidoreductase activity|glutaredoxin Reactome:R-HSA-111746 molecular_function owl:Class
GO:0003259 biolink:NamedThing cardioblast anterior-lateral migration The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti dph 2009-10-15T01:17:28Z biological_process owl:Class
GO:0003260 biolink:NamedThing cardioblast migration The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti dph 2009-10-15T01:52:25Z biological_process owl:Class
GO:0034200 biolink:NamedThing D,D-heptose 1,7-bisphosphate phosphatase activity Catalysis of the reaction: D-beta-D-heptose 1,7-bisphosphate + H2O = D-beta-D-heptose 1-phosphate + phosphate. got7fsn_ti RHEA:28518|MetaCyc:RXN0-4361 molecular_function owl:Class
GO:0060004 biolink:NamedThing reflex An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness. got7fsn_ti Wikipedia:Reflex biological_process owl:Class
GO:0052827 biolink:NamedThing inositol pentakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate. got7fsn_ti ai 2011-11-29T09:55:04Z molecular_function owl:Class
GO:0052745 biolink:NamedThing inositol phosphate phosphatase activity Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. got7fsn_ti ai 2011-09-14T01:50:04Z molecular_function owl:Class
GO:0032510 biolink:NamedThing endosome to lysosome transport via multivesicular body sorting pathway The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome. got7fsn_ti endosome to lysosome transport via MVB sorting pathway biological_process owl:Class
GO:0032262 biolink:NamedThing pyrimidine nucleotide salvage Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0070819 biolink:NamedThing menaquinone-dependent protoporphyrinogen oxidase activity Catalysis of the reaction: protoporphyrinogen IX + menaquinone = protoporphyrin IX + reduced menaquinone. got7fsn_ti protoporphyrinogen-IX:menaquinone oxidoreductase activity mah 2009-07-20T02:46:06Z molecular_function owl:Class
GO:0055062 biolink:NamedThing phosphate ion homeostasis Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0072506 biolink:NamedThing trivalent inorganic anion homeostasis Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell. got7fsn_ti Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'divalent inorganic anion homeostasis' ; GO:0072505'). mah 2010-12-16T01:39:39Z biological_process owl:Class
GO:0046944 biolink:NamedThing protein carbamoylation The addition of a carbamoyl group to a protein amino acid. A carbamoyl group is the acyl group -CO-NH2. got7fsn_ti protein amino acid carbamoylation biological_process owl:Class
GO:0097738 biolink:NamedThing substrate mycelium formation The process by which, in some fungal species, hyphae grow as a network of invasive thread-like filaments formed from chains of attached cells within a solid or semi-solid substrate. got7fsn_ti pr 2016-10-18T16:21:05Z biological_process owl:Class
GO:0072133 biolink:NamedThing metanephric mesenchyme morphogenesis The process in which the anatomical structures of a metanephric mesenchymal tissue are generated and organized. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. got7fsn_ti mah 2010-02-22T02:20:14Z biological_process owl:Class
GO:0072131 biolink:NamedThing kidney mesenchyme morphogenesis The process in which the anatomical structures of a kidney mesenchymal tissue are generated and organized. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. got7fsn_ti mah 2010-02-22T02:16:43Z biological_process owl:Class
GO:0045068 biolink:NamedThing negative extrathymic T cell selection The process of elimination of extrathymically maturing T cells which react strongly with self-antigens. got7fsn_ti negative extrathymic T lymphocyte selection|negative extrathymic T-cell selection|negative extrathymic T-lymphocyte selection biological_process owl:Class
GO:0043383 biolink:NamedThing negative T cell selection The process of elimination of immature T cells which react strongly with self-antigens. got7fsn_ti negative T-lymphocyte selection|negative T-cell selection|negative T lymphocyte selection biological_process owl:Class
GO:0060056 biolink:NamedThing mammary gland involution The tissue remodeling that removes differentiated mammary epithelia during weaning. got7fsn_ti biological_process owl:Class
GO:0030917 biolink:NamedThing midbrain-hindbrain boundary development The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. got7fsn_ti isthmus development|isthmic organizer development|MHB development|midbrain-hindbrain orgainizer development|isthmomesencephalic boundary development biological_process owl:Class
GO:0047053 biolink:NamedThing (S)-cheilanthifoline synthase activity Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-cheilanthifoline + [oxidized NADPH--hemoprotein reductase] + 2 H2O. got7fsn_ti (S)-scoulerine oxidase (methylenedioxy-bridge-forming) activity|(S)-scoulerine,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming) https://github.com/geneontology/go-ontology/issues/21133 MetaCyc:1.14.21.2-RXN|KEGG_REACTION:R03834|RHEA:20485|EC:1.14.19.65 molecular_function owl:Class
GO:0060320 biolink:NamedThing rejection of self pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the rejection of the self pollen by cells in the stigma. got7fsn_ti biological_process owl:Class
GO:0070913 biolink:NamedThing Ddb1-Wdr21 complex A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases. got7fsn_ti mah 2009-09-09T03:47:54Z cellular_component owl:Class
GO:0001522 biolink:NamedThing pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. got7fsn_ti pseudouridylation Wikipedia:Pseudouridine|Wikipedia:Pseudouridylation biological_process owl:Class
GO:0102694 biolink:NamedThing kinetin UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + 9-(alpha-D-glucosyl)kinetin + UDP. got7fsn_ti MetaCyc:RXN-4732 molecular_function owl:Class
GO:0018455 biolink:NamedThing alcohol dehydrogenase [NAD(P)+] activity Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+. got7fsn_ti aldehyde reductase (NADPH/NADH)|alcohol:NAD(P)+ oxidoreductase activity UM-BBD_reactionID:r0172|EC:1.1.1.71|RHEA:10736|MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN molecular_function owl:Class
GO:0060484 biolink:NamedThing lung-associated mesenchyme development The biological process whose specific outcome is the progression of a lung-associated mesenchyme from an initial condition to its mature state. This process begins with the formation of lung-associated mesenchyme and ends with the mature structure. Lung-associated mesenchyme is the tissue made up of loosely connected mesenchymal cells in the lung. got7fsn_ti pulmonary mesenchyme development|lung mesenchyme development biological_process owl:Class
GO:0060485 biolink:NamedThing mesenchyme development The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells. got7fsn_ti mesenchymal development biological_process owl:Class
GO:0030408 biolink:NamedThing glycine formimidoyltransferase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine. got7fsn_ti 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity|FIG formiminotransferase activity|formiminotransferase activity|glycine formiminotransferase activity|formiminoglycine formiminotransferase activity|formimidoyltransferase activity MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN|KEGG_REACTION:R02729|RHEA:24288|EC:2.1.2.4 molecular_function owl:Class
GO:0102277 biolink:NamedThing 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity Catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine. got7fsn_ti MetaCyc:RXN-12544 molecular_function owl:Class
GO:0031645 biolink:NamedThing negative regulation of nervous system process Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process. got7fsn_ti inhibition of neurological process|negative regulation of neurological system process|down regulation of neurological process|negative regulation of neurophysiological process|down-regulation of neurological process|negative regulation of neurological process|downregulation of neurological process biological_process owl:Class
GO:0070238 biolink:NamedThing activated T cell autonomous cell death A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen via the accumulation of pro-apoptotic gene products and decrease in anti-apoptotic gene products. got7fsn_ti activated T lymphocyte autonomous cell death|ACAD|activated T cell apoptosis|activated T-lymphocyte autonomous cell death|activated T-cell autonomous cell death|activated cell autonomous cell death biological_process owl:Class
GO:0102949 biolink:NamedThing 1,2-rhamnosyltransferase activity Catalysis of the reaction: isoorientin + an L-rhamonsylated rhamnosyl acceptor = isoorientin 2'-O-rhamnoside + a non rhamnosylated rhamnosyl acceptor. got7fsn_ti MetaCyc:RXN-9082 molecular_function owl:Class
GO:0070651 biolink:NamedThing nonfunctional rRNA decay An rRNA catabolic process that results in the targeted detection and degradation of aberrant rRNAs contained within translationally defective ribosomes, thereby acting as a quality-control system. got7fsn_ti NRD mah 2009-05-28T02:22:49Z biological_process owl:Class
GO:0016075 biolink:NamedThing rRNA catabolic process The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes. got7fsn_ti rRNA catabolism|rRNA degradation|rRNA breakdown biological_process owl:Class
GO:0071472 biolink:NamedThing cellular response to salt stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. got7fsn_ti cellular salinity response|cellular response to ionic osmotic stress mah 2009-12-18T11:48:23Z biological_process owl:Class
GO:0019980 biolink:NamedThing interleukin-5 binding Binding to interleukin-5. got7fsn_ti IL-5 binding molecular_function owl:Class
GO:0048839 biolink:NamedThing inner ear development The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0045511 biolink:NamedThing interleukin-25 binding Binding to interleukin-25. got7fsn_ti IL-25 binding molecular_function owl:Class
GO:1990846 biolink:NamedThing ribonucleoside-diphosphate reductase inhibitor activity Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase. got7fsn_ti vw 2015-09-04T18:13:15Z molecular_function owl:Class
GO:0051311 biolink:NamedThing meiotic metaphase plate congression The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis. got7fsn_ti metaphase plate congression during meiosis biological_process owl:Class
GO:0045183 biolink:NamedThing translation factor activity, non-nucleic acid binding A translation regulator activity that does not involve binding to nucleic acids. got7fsn_ti molecular_function owl:Class
GO:0055063 biolink:NamedThing sulfate ion homeostasis Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell. got7fsn_ti sulphate ion homeostasis|sulfate homeostasis GO:0080174 biological_process owl:Class
GO:0072505 biolink:NamedThing divalent inorganic anion homeostasis Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell. got7fsn_ti Note that this term was split from 'di-, tri-valent inorganic anion homeostasis ; GO:0055061' (sibling term 'trivalent inorganic anion homeostasis' ; GO:0072506'). mah 2010-12-16T01:39:00Z biological_process owl:Class
GO:0090644 biolink:NamedThing age-related resistance An innate immune response that is positively correlated with host plant development. As a plant develops, its innate resistance to pathogenic infections increases. The mechanisms involved in age-related resistance differ in nature or in aspects of regulation from the hypersensitive response (HR), systemic acquired resistance (SAR), or induced systemic resistance (ISR). got7fsn_ti developmental resistance|ARR|senescence-induced resistance|adult seedling resistance|mature seedling resistance|flowering-induced resistance|ontogenic resistance tb 2015-05-19T10:36:38Z biological_process owl:Class
GO:0038166 biolink:NamedThing angiotensin-activated signaling pathway The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti angiotensin II-mediated signaling pathway|angiotensin-mediated signaling pathway|angiotensin receptor signaling pathway bf 2012-05-14T03:09:03Z biological_process owl:Class
GO:0008078 biolink:NamedThing mesodermal cell migration The orderly movement of mesodermal cells from one site to another. got7fsn_ti mesoderm cell migration biological_process owl:Class
GO:0042827 biolink:NamedThing platelet dense granule Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. got7fsn_ti bull's eye body|platelet dense body cellular_component owl:Class
GO:0030141 biolink:NamedThing secretory granule A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules. got7fsn_ti secretory vesicle Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. cellular_component owl:Class
GO:0047107 biolink:NamedThing gamma-guanidinobutyraldehyde dehydrogenase activity Catalysis of the reaction: 4-guanidinobutanal + H(2)O + NAD(+) = 4-guanidinobutanoate + 2 H(+) + NADH. got7fsn_ti 4-guanidinobutanal:NAD+ 1-oxidoreductase activity|alpha-guanidinobutyraldehyde dehydrogenase activity|4-guanidinobutyraldehyde dehydrogenase activity|GBAL dehydrogenase activity MetaCyc:1.2.1.54-RXN|KEGG_REACTION:R03177|EC:1.2.1.54|RHEA:14381 molecular_function owl:Class
GO:0004029 biolink:NamedThing aldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. got7fsn_ti aldehyde:NAD+ oxidoreductase activity|NAD-dependent 4-hydroxynonenal dehydrogenase activity|NAD-linked aldehyde dehydrogenase activity|NAD-dependent aldehyde dehydrogenase activity|m-methylbenzaldehyde dehydrogenase activity|CoA-independent aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD+)|propionaldehyde dehydrogenase activity|NAD-aldehyde dehydrogenase activity Reactome:R-HSA-6808496|EC:1.2.1.3|Reactome:R-HSA-71723|Reactome:R-HSA-6808487|RHEA:16185|Reactome:R-HSA-6813749|Reactome:R-HSA-380608|Wikipedia:Aldehyde_dehydrogenase_(NAD+)|Reactome:R-HSA-5692261|Reactome:R-HSA-71691|Reactome:R-HSA-5696091|MetaCyc:ALDHDEHYDROG-RXN|Reactome:R-HSA-389609|UM-BBD_enzymeID:e0024 molecular_function owl:Class
GO:0000289 biolink:NamedThing nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. got7fsn_ti mRNA deadenylation|3' to 5' mRNA deadenylation|nuclear mRNA poly(A) tail shortening biological_process owl:Class
GO:0043250 biolink:NamedThing sodium-dependent organic anion transmembrane transporter activity Enables the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner. got7fsn_ti molecular_function owl:Class
GO:0034958 biolink:NamedThing aminohydroquinone monooxygenase activity Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3. got7fsn_ti UM-BBD_reactionID:r1497|EC:3.5.99.- molecular_function owl:Class
GO:0016810 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. got7fsn_ti hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds EC:3.5.-.-|Reactome:R-HSA-6803753 molecular_function owl:Class
GO:0097465 biolink:NamedThing somatic spine Spine emanating from the cell soma of a neuron. got7fsn_ti pr 2012-12-21T08:02:37Z NIF_Subcellular:sao2048514053 cellular_component owl:Class
GO:0044309 biolink:NamedThing neuron spine A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. got7fsn_ti spine jl 2010-02-05T04:25:10Z NIF_Subcellular:sao1145756102 cellular_component owl:Class
GO:0032358 biolink:NamedThing oxidized pyrimidine DNA binding Binding to a DNA region containing an oxidized pyrimidine residue. got7fsn_ti oxidised pyrimidine DNA binding|oxidized pyrimidine nucleobase DNA binding|oxidized pyrimidine base DNA binding molecular_function owl:Class
GO:0032356 biolink:NamedThing oxidized DNA binding Binding to a DNA region containing an oxidized residue. got7fsn_ti oxidised DNA binding molecular_function owl:Class
GO:0060464 biolink:NamedThing lung lobe formation The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung. got7fsn_ti biological_process owl:Class
GO:0019235 biolink:NamedThing sensory perception of slow pain The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction. got7fsn_ti biological_process owl:Class
GO:0019233 biolink:NamedThing sensory perception of pain The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. got7fsn_ti nociception|perception of physiological pain Wikipedia:Nociception biological_process owl:Class
GO:0061712 biolink:NamedThing tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine. got7fsn_ti dph 2015-06-23T08:47:10Z EC:2.8.4.5|MetaCyc:RXN-14531|RHEA:37075 molecular_function owl:Class
GO:0009902 biolink:NamedThing chloroplast relocation The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery. got7fsn_ti chloroplast movement biological_process owl:Class
GO:0051667 biolink:NamedThing establishment of plastid localization The directed movement of a plastid to a specific location in the cell. got7fsn_ti establishment of plastid localisation biological_process owl:Class
GO:0021556 biolink:NamedThing central nervous system formation The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. got7fsn_ti biological_process owl:Class
GO:0044486 biolink:NamedThing modulation of transmission of nerve impulse in other organism The process in which an organism effects a change in the transmission of a nerve impulse in another organism. got7fsn_ti modulation of conduction of nerve impulse in other organism|regulation of transmission of nerve impulse in other organism jl 2012-01-26T04:03:31Z biological_process owl:Class
GO:0120165 biolink:NamedThing perithecium development The process whose specific outcome is the progression of a perithecium over time, from its formation to the mature structure. Peritheicum is a flask-shaped fruiting body of certain molds and ascomycetous fungi having a pore for the escape of spores. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck. got7fsn_ti krc 2018-05-17T17:17:44Z biological_process owl:Class
GO:0030582 biolink:NamedThing reproductive fruiting body development The process whose specific outcome is the progression of a reproductive fruiting body over time, from its formation to the mature structure. A reproductive fruiting body is a multicellular reproductive structure that contains spores. got7fsn_ti fruiting body formation This term describes the development of a fruiting body that is a spore-bearing organ. It is not intended to describe the development of myxococcal fruiting bodies. biological_process owl:Class
GO:0002078 biolink:NamedThing membrane fusion involved in acrosome reaction The fusion of the plasma membrane of the sperm with the outer acrosomal membrane. got7fsn_ti membrane fusion involved in the acrosomal reaction biological_process owl:Class
GO:0032002 biolink:NamedThing interleukin-28 receptor complex A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1). got7fsn_ti IL-28 receptor complex cellular_component owl:Class
GO:0060177 biolink:NamedThing regulation of angiotensin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving angiotensin. got7fsn_ti regulation of angiotensin metabolism biological_process owl:Class
GO:0051246 biolink:NamedThing regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. got7fsn_ti regulation of protein metabolism biological_process owl:Class
GO:0043936 biolink:NamedThing asexual sporulation resulting in formation of a cellular spore The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. got7fsn_ti asexual sporulation resulting in the formation of a viable spore|asexual reproduction resulting in the formation of a cellular spore biological_process owl:Class
GO:0030436 biolink:NamedThing asexual sporulation The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi. got7fsn_ti asexual spore formation|mitotic spore formation|mitotic sporulation|asexual reproductive sporulation biological_process owl:Class
GO:0042255 biolink:NamedThing ribosome assembly The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. got7fsn_ti ribosomal subunit assembly GO:0042257 biological_process owl:Class
GO:0097196 biolink:NamedThing Shu complex A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p. got7fsn_ti pr 2011-12-01T05:11:08Z cellular_component owl:Class
GO:0051873 biolink:NamedThing killing by host of symbiont cells Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti disruption by host of symbiont cells https://github.com/geneontology/go-ontology/issues/18719 GO:0051852 biological_process owl:Class
GO:0051883 biolink:NamedThing killing of cells in other organism involved in symbiotic interaction Any process mediated by an organism that results in the death of cells in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti killing of cells in other organism during symbiotic interaction biological_process owl:Class
GO:0034304 biolink:NamedThing actinomycete-type spore formation The process in which differentiated, resting cells are formed from a substrate mycelium; characteristic of many members of the order Actinomycetales. got7fsn_ti biological_process owl:Class
GO:0051065 biolink:NamedThing CTP reductase activity Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. got7fsn_ti CTP reduction EC:1.17.4.- molecular_function owl:Class
GO:0008998 biolink:NamedThing ribonucleoside-triphosphate reductase activity Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin. got7fsn_ti 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity|2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity|ribonucleotide reductase activity MetaCyc:1.17.4.2-RXN|RHEA:12701|EC:1.17.4.2 molecular_function owl:Class
GO:0097475 biolink:NamedThing motor neuron migration The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. got7fsn_ti pr 2013-04-23T13:00:46Z biological_process owl:Class
GO:0140515 biolink:NamedThing mitotic nuclear bridge organization A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the mitotic nuclear bridge during closed mitosis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19948 pg 2020-09-09T14:04:33Z biological_process owl:Class
GO:0101024 biolink:NamedThing mitotic nuclear membrane organization A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis. got7fsn_ti nuclear membrane organization involved in mitotic nuclear division https://github.com/geneontology/go-ontology/issues/19949 This process only occurs in organisms which undergo 'closed mitosis' without nuclear breakdown. biological_process owl:Class
GO:0080016 biolink:NamedThing (-)-E-beta-caryophyllene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-E-beta-caryophyllene + diphosphate. got7fsn_ti EC:4.2.3.57|MetaCyc:RXN-8414|RHEA:28294 molecular_function owl:Class
GO:0010334 biolink:NamedThing sesquiterpene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons. got7fsn_ti molecular_function owl:Class
GO:0019821 biolink:NamedThing P3 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content. got7fsn_ti peroxisome vesicle Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. cellular_component owl:Class
GO:0051666 biolink:NamedThing actin cortical patch localization Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells. got7fsn_ti actin cortical patch localisation|establishment and maintenance of actin cortical patch localization biological_process owl:Class
GO:0051641 biolink:NamedThing cellular localization A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane. got7fsn_ti single-organism cellular localization|establishment and maintenance of cellular localization|localization within cell|establishment and maintenance of localization in cell or cell membrane|single organism cellular localization|cellular localisation|intracellular localization jl 2013-12-18T14:04:32Z GO:1902580 biological_process owl:Class
GO:0052895 biolink:NamedThing N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide. got7fsn_ti N1-acetylspermine oxidase activity MetaCyc:POLYAMINE-OXIDASE-RXN|EC:1.5.3.16 molecular_function owl:Class
GO:0018178 biolink:NamedThing peptidyl-threonine adenylylation The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine. got7fsn_ti peptidyl-threonine adenylation RESID:AA0267 biological_process owl:Class
GO:0075134 biolink:NamedThing induction by symbiont of host calcium or calmodulin-mediated signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of calcium or calmodulin-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host calcium or calmodulin-mediated signal transduction|positive regulation by symbiont of host Ca++ or calmodulin-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction ; GO:0075104". biological_process owl:Class
GO:0051391 biolink:NamedThing tRNA acetylation The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti biological_process owl:Class
GO:1990884 biolink:NamedThing RNA acetylation The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule. got7fsn_ti mah 2015-10-28T16:28:08Z biological_process owl:Class
GO:0070661 biolink:NamedThing leukocyte proliferation The expansion of a leukocyte population by cell division. got7fsn_ti mah 2009-05-28T05:25:28Z biological_process owl:Class
GO:0072298 biolink:NamedThing regulation of metanephric glomerulus development Any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. got7fsn_ti mah 2010-04-09T05:03:14Z biological_process owl:Class
GO:0044289 biolink:NamedThing mitochondrial inner-outer membrane contact site Sites of close apposition of the inner and outer mitochondrial membrane. got7fsn_ti contact site|bridge contact site https://github.com/geneontology/go-ontology/issues/18994 jl 2010-02-04T02:25:11Z GO:0044285 cellular_component owl:Class
GO:0007630 biolink:NamedThing jump response The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0018909 biolink:NamedThing dodecyl sulfate metabolic process The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants. got7fsn_ti dodecyl sulfate metabolism|dodecyl sulphate metabolic process|dodecyl sulphate metabolism UM-BBD_pathwayID:dds biological_process owl:Class
GO:0061051 biolink:NamedThing positive regulation of cell growth involved in cardiac muscle cell development Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. got7fsn_ti dph 2010-02-25T01:08:08Z biological_process owl:Class
GO:0051155 biolink:NamedThing positive regulation of striated muscle cell differentiation Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation. got7fsn_ti upregulation of striated muscle cell differentiation|activation of striated muscle cell differentiation|stimulation of striated muscle cell differentiation|up-regulation of striated muscle cell differentiation|up regulation of striated muscle cell differentiation biological_process owl:Class
GO:0042395 biolink:NamedThing ecdysis, collagen and cuticulin-based cuticle The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates. got7fsn_ti biological_process owl:Class
GO:0021568 biolink:NamedThing rhombomere 2 development The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0021546 biolink:NamedThing rhombomere development The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. got7fsn_ti biological_process owl:Class
GO:0036456 biolink:NamedThing L-methionine-(S)-S-oxide reductase activity Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O. got7fsn_ti bf 2013-11-27T11:07:19Z RHEA:19995 molecular_function owl:Class
GO:0033744 biolink:NamedThing L-methionine:thioredoxin-disulfide S-oxidoreductase activity Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. got7fsn_ti methionine-S-oxide reductase activity|acetylmethionine sulfoxide reductase activity|methionine sulfoxide reductase activity|L-methionine:oxidized-thioredoxin S-oxidoreductase activity|free-methionine (S)-S-oxide reductase activity|fSMsr|L-methionine-(S)-S-oxide reductase activity|methyl sulfoxide reductase I and II activity GO:0000317 KEGG_REACTION:R07606|MetaCyc:1.8.4.13-RXN|RHEA:19993|EC:1.8.4.13 molecular_function owl:Class
GO:0050162 biolink:NamedThing oxalate oxidase activity Catalysis of the reaction: 2 H(+) + O(2) + oxalate = 2 CO(2) + H(2)O(2). got7fsn_ti oxalate:oxygen oxidoreductase activity|oxalic acid oxidase activity|aero-oxalo dehydrogenase activity RHEA:21880|MetaCyc:OXALATE-OXIDASE-RXN|EC:1.2.3.4|KEGG_REACTION:R00273 molecular_function owl:Class
GO:0018744 biolink:NamedThing limonene-1,2-epoxide hydrolase activity Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide. got7fsn_ti limonene oxide hydrolase activity RHEA:10700|MetaCyc:3.3.2.8-RXN|UM-BBD_reactionID:r0734|EC:3.3.2.8 molecular_function owl:Class
GO:0030948 biolink:NamedThing negative regulation of vascular endothelial growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. got7fsn_ti down regulation of vascular endothelial growth factor receptor signaling pathway|inhibition of vascular endothelial growth factor receptor signaling pathway|downregulation of vascular endothelial growth factor receptor signaling pathway|negative regulation of vascular endothelial growth factor receptor signalling pathway|negative regulation of VEGF receptor signaling pathway|negative regulation of VEGF receptor signalling pathway|down-regulation of vascular endothelial growth factor receptor signaling pathway biological_process owl:Class
GO:0090288 biolink:NamedThing negative regulation of cellular response to growth factor stimulus Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. got7fsn_ti tb 2010-02-18T03:01:25Z biological_process owl:Class
GO:0071478 biolink:NamedThing cellular response to radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. got7fsn_ti cellular response to radiation stimulus|cellular response to electromagnetic radiation stimulus Note that 'radiation' refers to electromagnetic radiation of any wavelength. mah 2009-12-18T01:59:37Z biological_process owl:Class
GO:0071214 biolink:NamedThing cellular response to abiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. got7fsn_ti cellular response to abiotic stress Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. mah 2009-12-03T01:02:11Z biological_process owl:Class
GO:0075120 biolink:NamedThing suppression by symbiont of host G protein-coupled receptor signal transduction Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host G-protein coupled receptor protein signal transduction|negative regulation by symbiont of host signal transduction mediated by G-protein beta subunit|negative regulation by symbiont of host G protein-coupled receptor signal transduction|negative regulation by symbiont of host signal transduction mediated by G-protein gamma subunit|negative regulation by symbiont of host signal transduction mediated by G-protein alpha subunit Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075089". GO:0075126|GO:0075129|GO:0075123 biological_process owl:Class
GO:0075114 biolink:NamedThing suppression by symbiont of host transmembrane receptor-mediated signal transduction Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host transmembrane receptor-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont transmembrane receptor-mediated signal transduction ; GO:0075083". biological_process owl:Class
GO:0048596 biolink:NamedThing embryonic camera-type eye morphogenesis The process in which the anatomical structures of the eye are generated and organized during embryonic development. got7fsn_ti embryonic eye morphogenesis biological_process owl:Class
GO:0048048 biolink:NamedThing embryonic eye morphogenesis The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized. got7fsn_ti biological_process owl:Class
GO:0001097 biolink:NamedThing TFIIH-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. got7fsn_ti TFIIH-class transcription factor binding krc 2010-10-28T02:51:41Z molecular_function owl:Class
GO:0060688 biolink:NamedThing regulation of morphogenesis of a branching structure Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized. got7fsn_ti dph 2009-06-05T12:41:44Z biological_process owl:Class
GO:0022603 biolink:NamedThing regulation of anatomical structure morphogenesis Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis. got7fsn_ti regulation of morphogenesis biological_process owl:Class
GO:0001769 biolink:NamedThing establishment of B cell polarity The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell. got7fsn_ti establishment of B-cell polarity|B-cell polarization|establishment of B lymphocyte polarity|B cell polarization|establishment of B-lymphocyte polarity|B lymphocyte polarization Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. biological_process owl:Class
GO:0001767 biolink:NamedThing establishment of lymphocyte polarity The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell. got7fsn_ti lymphocyte polarization biological_process owl:Class
GO:0032140 biolink:NamedThing single adenine insertion binding Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine. got7fsn_ti molecular_function owl:Class
GO:0032138 biolink:NamedThing single base insertion or deletion binding Binding to a double-stranded DNA region containing a single base insertion or deletion. got7fsn_ti single base insertion binding molecular_function owl:Class
GO:0031232 biolink:NamedThing extrinsic component of external side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to external leaflet of plasma membrane|extrinsic to external side of plasma membrane cellular_component owl:Class
GO:1901276 biolink:NamedThing tartrate catabolic process The chemical reactions and pathways resulting in the breakdown of tartrate. got7fsn_ti tartrate catabolism|tartrate breakdown|tartrate degradation yaf 2012-08-17T14:52:40Z biological_process owl:Class
GO:0009056 biolink:NamedThing catabolic process The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. got7fsn_ti single-organism catabolic process|degradation|breakdown|catabolism|multicellular organismal catabolic process jl 2012-10-17T15:52:35Z GO:0044243|GO:0044712 Wikipedia:Catabolism biological_process owl:Class
GO:0070647 biolink:NamedThing protein modification by small protein conjugation or removal A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein. got7fsn_ti mah 2009-05-11T02:54:03Z biological_process owl:Class
GO:0038182 biolink:NamedThing G protein-coupled bile acid receptor activity Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G-protein coupled bile acid receptor activity|cell surface bile acid receptor|membrane bile acid receptor activity bf 2013-05-16T10:29:42Z Wikipedia:G_protein-coupled_bile_acid_receptor molecular_function owl:Class
GO:0033405 biolink:NamedThing UCU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCU codon. got7fsn_ti TCT codon-amino acid adaptor activity|serine tRNA Note that in the standard genetic code, TCT codes for serine. molecular_function owl:Class
GO:0033448 biolink:NamedThing AGG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AGG codon. got7fsn_ti arginine tRNA Note that in the standard genetic code, AGG codes for arginine. molecular_function owl:Class
GO:0008746 biolink:NamedThing NAD(P)+ transhydrogenase activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. got7fsn_ti NADH transhydrogenase|NADPH-NAD oxidoreductase|NADH-NADP-transhydrogenase|pyridine nucleotide transferase|NADPH:NAD+ transhydrogenase|nicotinamide adenine dinucleotide (phosphate) transhydrogenase|H+-thase|energy-linked transhydrogenase|NAD transhydrogenase|NADPH-NAD transhydrogenase RHEA:11692|Reactome:R-HSA-450971|KEGG_REACTION:R00112|EC:1.6.1.1 molecular_function owl:Class
GO:0016652 biolink:NamedThing oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP. got7fsn_ti oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor EC:1.6.1.- molecular_function owl:Class
GO:0051704 biolink:NamedThing multi-organism process A biological process which involves another organism of the same or different species. got7fsn_ti interaction between organisms|physiological interaction with other organism|physiological interaction between organisms GO:0051706 biological_process owl:Class
GO:0070431 biolink:NamedThing nucleotide-binding oligomerization domain containing 2 signaling pathway Any series of molecular signals generated as a consequence of binding to nucleotide-binding oligomerization domain containing 2 (NOD2). got7fsn_ti NOD2 signaling pathway|nucleotide-binding oligomerization domain containing 2 signalling pathway biological_process owl:Class
GO:0022612 biolink:NamedThing gland morphogenesis The process in which the anatomical structures of a gland are generated and organized. got7fsn_ti biological_process owl:Class
GO:0018538 biolink:NamedThing epoxide carboxylase activity Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+. got7fsn_ti molecular_function owl:Class
GO:0016651 biolink:NamedThing oxidoreductase activity, acting on NAD(P)H Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on NADH or NADPH|NAD(P)H dehydrogenase|oxidoreductase activity, acting on NADH or NADPH, other acceptor Reactome:R-HSA-109343|EC:1.6.-.-|Reactome:R-HSA-8956458 molecular_function owl:Class
GO:0018126 biolink:NamedThing protein hydroxylation The addition of a hydroxy group to a protein amino acid. got7fsn_ti protein amino acid hydroxylation biological_process owl:Class
GO:1900969 biolink:NamedThing negative regulation of sarcinapterin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of sarcinapterin metabolic process. got7fsn_ti downregulation of sarcinapterin metabolism|down regulation of sarcinapterin metabolic process|inhibition of sarcinapterin metabolic process|down-regulation of sarcinapterin metabolic process|downregulation of sarcinapterin metabolic process|negative regulation of sarcinapterin metabolism|down-regulation of sarcinapterin metabolism|down regulation of sarcinapterin metabolism|inhibition of sarcinapterin metabolism tt 2012-06-14T03:58:35Z biological_process owl:Class
GO:0045863 biolink:NamedThing negative regulation of pteridine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pteridine. got7fsn_ti down regulation of pteridine metabolic process|downregulation of pteridine metabolic process|inhibition of pteridine metabolic process|down-regulation of pteridine metabolic process|negative regulation of pteridine metabolism biological_process owl:Class
GO:0044625 biolink:NamedThing envenomation resulting in negative regulation of cell migration in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of cell migration in the bitten organism. got7fsn_ti jl 2012-07-04T05:07:16Z biological_process owl:Class
GO:0002901 biolink:NamedThing mature B cell apoptotic process Any apoptotic process in a B cell that is mature, having left the bone marrow. got7fsn_ti mature B-lymphocyte programmed cell death by apoptosis|apoptosis of mature B lymphocytes|programmed cell death, mature B lymphocytes|mature B-cell programmed cell death by apoptosis|programmed cell death of mature B-lymphocytes by apoptosis|apoptosis of mature B-lymphocytes|mature B lymphocyte apoptosis|programmed cell death of mature B-cells by apoptosis|mature B cell apoptosis|mature B-cell apoptosis|programmed cell death, mature B-lymphocytes|mature B-lymphocyte apoptosis|programmed cell death of mature B lymphocytes by apoptosis|mature B cell programmed cell death by apoptosis|programmed cell death of mature B cells by apoptosis|apoptosis of mature B cells|programmed cell death, mature B cells|apoptosis of mature B-cells|mature B lymphocyte programmed cell death by apoptosis|programmed cell death, mature B-cells biological_process owl:Class
GO:0001783 biolink:NamedThing B cell apoptotic process Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. got7fsn_ti programmed cell death of B-lymphocytes by apoptosis|programmed cell death, B-lymphocytes|B-lymphocyte programmed cell death by apoptosis|programmed cell death, B-cells|programmed cell death of B cells by apoptosis|B lymphocyte apoptosis|apoptosis of B lymphocytes|B-cell apoptosis|B-cell programmed cell death by apoptosis|apoptosis of B cells|B cell programmed cell death by apoptosis|programmed cell death, B lymphocytes|B lymphocyte programmed cell death by apoptosis|apoptosis of B-cells|programmed cell death of B lymphocytes by apoptosis|B cell apoptosis|programmed cell death of B-cells by apoptosis|programmed cell death, B cells|B-lymphocyte apoptosis|apoptosis of B-lymphocytes biological_process owl:Class
GO:0031288 biolink:NamedThing sorocarp morphogenesis The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum. got7fsn_ti fruiting body morphogenesis biological_process owl:Class
GO:0021961 biolink:NamedThing posterior commissure morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon. got7fsn_ti biological_process owl:Class
GO:0044359 biolink:NamedThing modulation of molecular function in other organism The process in which an organism effects a change in the function of proteins in a second organism. got7fsn_ti jl 2011-10-27T01:28:16Z biological_process owl:Class
GO:0009453 biolink:NamedThing energy taxis The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates. got7fsn_ti taxis in response to energy source|energytaxis biological_process owl:Class
GO:0042330 biolink:NamedThing taxis The directed movement of a motile cell or organism in response to an external stimulus. got7fsn_ti directed movement in response to stimulus Wikipedia:Taxis biological_process owl:Class
GO:0070414 biolink:NamedThing trehalose metabolism in response to heat stress The chemical reactions and pathways involving trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. got7fsn_ti trehalose metabolic process involved in response to heat stress biological_process owl:Class
GO:0002192 biolink:NamedThing IRES-dependent translational initiation of linear mRNA The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation. got7fsn_ti hjd 2011-08-11T02:32:45Z biological_process owl:Class
GO:0110017 biolink:NamedThing cap-independent translational initiation of linear mRNA The process where translation initiation recruits the 40S ribosomal subunits in a cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation. got7fsn_ti kmv 2017-06-08T15:13:55Z biological_process owl:Class
GO:0038020 biolink:NamedThing insulin receptor recycling The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. got7fsn_ti bf 2011-06-23T04:52:05Z biological_process owl:Class
GO:0001881 biolink:NamedThing receptor recycling The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal. got7fsn_ti biological_process owl:Class
GO:1990968 biolink:NamedThing modulation by host of RNA binding by virus A process in which a host organism modulates the frequency, rate or extent of a viral gene product binding to RNA. got7fsn_ti modulation by host of viral protein:RNA interaction Note that the bound RNA may originate from the virus or another organism, including the host. bf 2016-06-21T11:56:10Z biological_process owl:Class
GO:1905214 biolink:NamedThing regulation of RNA binding Any process that modulates the frequency, rate or extent of RNA binding. got7fsn_ti bf 2016-06-06T10:20:56Z biological_process owl:Class
GO:0140110 biolink:NamedThing transcription regulator activity A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons. got7fsn_ti https://github.com/geneontology/go-ontology/issues/13588 pg 2017-10-18T07:05:44Z molecular_function owl:Class
GO:0010621 biolink:NamedThing negative regulation of transcription by transcription factor localization Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor. got7fsn_ti negative regulation of transcription by transcription factor localisation biological_process owl:Class
GO:0097177 biolink:NamedThing mitochondrial ribosome binding Binding to a mitochondrial ribosome. got7fsn_ti pr 2011-10-11T03:03:03Z molecular_function owl:Class
GO:0043022 biolink:NamedThing ribosome binding Binding to a ribosome. got7fsn_ti ribosome receptor activity GO:0030376 molecular_function owl:Class
GO:0002425 biolink:NamedThing tolerance induction in urogenital tract Tolerance induction taking place in the urogenital tract. got7fsn_ti biological_process owl:Class
GO:0002427 biolink:NamedThing mucosal tolerance induction Tolerance induction taking place in the mucosal tissues. got7fsn_ti biological_process owl:Class
GO:0120044 biolink:NamedThing stereocilium base The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium. got7fsn_ti stereocilium taper krc 2017-05-15T20:45:06Z cellular_component owl:Class
GO:0031330 biolink:NamedThing negative regulation of cellular catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells. got7fsn_ti negative regulation of cellular degradation|negative regulation of cellular catabolism|inhibition of cellular catabolic process|down regulation of cellular catabolic process|down-regulation of cellular catabolic process|downregulation of cellular catabolic process|negative regulation of cellular breakdown biological_process owl:Class
GO:0009895 biolink:NamedThing negative regulation of catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. got7fsn_ti negative regulation of catabolism|down regulation of catabolic process|downregulation of catabolic process|inhibition of catabolic process|down-regulation of catabolic process|negative regulation of degradation|negative regulation of breakdown biological_process owl:Class
GO:0019490 biolink:NamedThing 2-aminobenzenesulfonate desulfonation The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. got7fsn_ti 2-aminobenzenesulphonate desulphonation MetaCyc:2ASDEG-PWY biological_process owl:Class
GO:0018868 biolink:NamedThing 2-aminobenzenesulfonate metabolic process The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. got7fsn_ti 2-aminobenzenesulfonate metabolism|2-aminobenzenesulphonate metabolism|2-aminobenzenesulphonate metabolic process UM-BBD_pathwayID:abs biological_process owl:Class
GO:0075503 biolink:NamedThing fusion of virus membrane with host macropinosome membrane Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm. got7fsn_ti viral entry into host cell via macropinocytosis followed by membrane fusion with the host macropinosome membrane|viral entry into host cell via macropinocytosis followed by membrane fusion with the endosome membrane jl 2010-06-02T02:45:47Z biological_process owl:Class
GO:0039654 biolink:NamedThing fusion of virus membrane with host endosome membrane Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell. got7fsn_ti fusion of virus membrane with host endosomal membrane|viral penetration via endocytosis followed by caveolae-mediated membrane fusion with the endosome membrane|viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane|viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane|viral entry into host cell via caveolae-mediated endocytosis followed by membrane fusion with the endosome membrane|viral penetration via endocytosis followed by clathrin-mediated membrane fusion with the endosome membrane|viral entry into host cell via endocytosis followed by membrane fusion with host endosome|viral entry into host cell via endocytosis followed by membrane fusion with the endosome membrane bf 2013-06-20T14:24:05Z GO:0075501|GO:0075517 VZ:992 biological_process owl:Class
GO:1990860 biolink:NamedThing Pho85-Pho80 CDK-cyclin complex A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin. got7fsn_ti rb 2015-09-24T17:53:50Z cellular_component owl:Class
GO:0008212 biolink:NamedThing mineralocorticoid metabolic process The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance. got7fsn_ti mineralocorticoid metabolism biological_process owl:Class
GO:0008202 biolink:NamedThing steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. got7fsn_ti steroid metabolism Wikipedia:Steroid_metabolism biological_process owl:Class
GO:0004510 biolink:NamedThing tryptophan 5-monooxygenase activity Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O. got7fsn_ti indoleacetic acid-5-hydroxylase activity|L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)|tryptophan 5-hydroxylase activity|L-tryptophan hydroxylase activity|tryptophan hydroxylase activity MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN|RHEA:16709|Reactome:R-HSA-209828|EC:1.14.16.4 molecular_function owl:Class
GO:0039612 biolink:NamedThing modulation by virus of host protein phosphorylation Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host. got7fsn_ti bf 2012-07-06T11:13:59Z biological_process owl:Class
GO:0019054 biolink:NamedThing modulation by virus of host cellular process The process in which a virus effects a change in the processes and activities of its host organism. got7fsn_ti regulation of cellular process in host by virus|modulation of cellular process in host by virus|regulation by virus of host cellular process|viral host cell process manipulation|regulation of host cellular process by virus|modification by virus of host cellular process|modulation by virus of host process biological_process owl:Class
GO:0021945 biolink:NamedThing positive regulation of cerebellar granule cell migration by calcium The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration. got7fsn_ti calcium-mediated up regulation of granule cell migration|calcium-mediated upregulation of granule cell migration|calcium-mediated up-regulation of granule cell migration|calcium-mediated activation of granule cell migration|calcium-mediated stimulation of granule cell migration|calcium-mediated positive regulation of granule cell migration biological_process owl:Class
GO:0030335 biolink:NamedThing positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration. got7fsn_ti stimulation of cell migration|activation of cell migration|upregulation of cell migration|up regulation of cell migration|up-regulation of cell migration biological_process owl:Class
GO:1990020 biolink:NamedThing recurrent axon collateral Axon collateral that ramifies in the area of the soma of the cell of origin. got7fsn_ti recurrent collateral pr 2013-01-10T16:04:31Z NIF_Subcellular:sao1642494436 cellular_component owl:Class
GO:0044303 biolink:NamedThing axon collateral Any of the smaller branches of an axon that emanate from the main axon cylinder. got7fsn_ti jl 2010-02-05T11:29:04Z NIF_Subcellular:sao1470140754 cellular_component owl:Class
GO:0061758 biolink:NamedThing 2-hydroxyglutarate dehydrogenase activity, forward reaction Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor -> 2-oxoglutarate + reduced acceptor. got7fsn_ti alpha-ketoglutarate reductase activity, reverse reaction dph 2016-03-07T08:28:58Z RHEA:21253 molecular_function owl:Class
GO:0047545 biolink:NamedThing 2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. got7fsn_ti hydroxyglutaric dehydrogenase activity|(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase|alpha-hydroxyglutarate oxidoreductase activity|(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase|alpha-hydroxyglutarate dehydrogenase (NAD+ specific)|L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase|L-alpha-hydroxyglutarate dehydrogenase activity|alpha-hydroxyglutarate dehydrogenase activity Reactome:R-HSA-880050|RHEA:21252|EC:1.1.99.2|MetaCyc:2-HYDROXYGLUTARATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0018750 biolink:NamedThing biuret amidohydrolase activity Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3. got7fsn_ti EC:3.5.1.84|UM-BBD_reactionID:r0846|RHEA:17525 molecular_function owl:Class
GO:0000138 biolink:NamedThing Golgi trans cisterna The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed. got7fsn_ti late Golgi cellular_component owl:Class
GO:0031985 biolink:NamedThing Golgi cisterna Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex. got7fsn_ti Golgi lamellae NIF_Subcellular:sao561419532 cellular_component owl:Class
GO:0031103 biolink:NamedThing axon regeneration The regrowth of axons following their loss or damage. got7fsn_ti biological_process owl:Class
GO:0061564 biolink:NamedThing axon development The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation). got7fsn_ti dph 2013-07-18T14:43:01Z biological_process owl:Class
GO:0048563 biolink:NamedThing post-embryonic animal organ morphogenesis Morphogenesis, during the post-embryonic phase, of an animal tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti biological_process owl:Class
GO:0016334 biolink:NamedThing establishment or maintenance of polarity of follicular epithelium Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet. got7fsn_ti biological_process owl:Class
GO:0071486 biolink:NamedThing cellular response to high light intensity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus. got7fsn_ti mah 2009-12-18T02:13:23Z biological_process owl:Class
GO:0071484 biolink:NamedThing cellular response to light intensity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus. got7fsn_ti mah 2009-12-18T02:11:03Z biological_process owl:Class
GO:0034947 biolink:NamedThing terephthalate decarboxylase activity Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-. got7fsn_ti UM-BBD_reactionID:r0321 molecular_function owl:Class
GO:1990033 biolink:NamedThing dendritic branch point The part of a dendritic tree where it branches, giving rise to a dendritic branch. got7fsn_ti branch point of dendrite pr 2013-02-07T13:01:01Z NIF_Subcellular:sao1348591767 cellular_component owl:Class
GO:0061845 biolink:NamedThing neuron projection branch point The location where a secondary projection arises from a neuron projection. got7fsn_ti cellular_component owl:Class
GO:0090535 biolink:NamedThing WICH complex An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair. got7fsn_ti tb 2013-02-11T14:07:14Z cellular_component owl:Class
GO:0031010 biolink:NamedThing ISWI-type complex Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair. got7fsn_ti cellular_component owl:Class
GO:0000776 biolink:NamedThing kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. got7fsn_ti condensed chromosome kinetochore|condensed nuclear chromosome kinetochore https://github.com/geneontology/go-ontology/issues/21126 Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore. GO:0000778|GO:0005699|GO:0000777 Wikipedia:Kinetochore cellular_component owl:Class
GO:0051702 biolink:NamedThing biological process involved in interaction with symbiont An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism. got7fsn_ti interaction with symbiont https://github.com/geneontology/go-ontology/issues/20191 biological_process owl:Class
GO:0039513 biolink:NamedThing suppression by virus of host catalytic activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. got7fsn_ti down-regulation by virus of host enzyme activity|inhibition by virus of host catalytic activity|downregulation by virus of host catalytic activity|negative regulation by virus of host catalytic activity bf 2011-06-16T02:32:49Z biological_process owl:Class
GO:0039516 biolink:NamedThing modulation by virus of host catalytic activity The process in which a virus effects a change in host enzyme activity. got7fsn_ti regulation of host catalytic activity by virus|modulation of catalytic activity of host by virus|regulation by virus of host catalytic activity bf 2011-06-16T02:59:35Z biological_process owl:Class
GO:0070449 biolink:NamedThing elongin complex A transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits. got7fsn_ti transcription factor B (SIII) complex|transcription elongation factor SIII complex|elongin (SIII) complex See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. cellular_component owl:Class
GO:0102422 biolink:NamedThing curcumin-4'-O-beta-D-gentiotrioside 1,6-glucosyltransferase activity Catalysis of the reaction: curcumin 4'-O-beta-D-gentiotrioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotetraside + UDP + H+. got7fsn_ti MetaCyc:RXN-13814 molecular_function owl:Class
GO:1990684 biolink:NamedThing protein-lipid-RNA complex A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other. got7fsn_ti miRNA-lipoprotein complex Examples of protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle' or GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs. pr 2015-03-11T14:24:33Z cellular_component owl:Class
GO:0140007 biolink:NamedThing KICSTOR complex A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2. got7fsn_ti pg 2017-03-10T12:47:30Z cellular_component owl:Class
GO:0098750 biolink:NamedThing FYXD domain binding Binding to a FXYD domain. got7fsn_ti molecular_function owl:Class
GO:0000234 biolink:NamedThing phosphoethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. got7fsn_ti phosphoethanolamine methyltransferase activity|S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity MetaCyc:2.1.1.103-RXN|RHEA:20365|EC:2.1.1.103|KEGG_REACTION:R02037 molecular_function owl:Class
GO:1990655 biolink:NamedThing 4 iron, 3 sulfur cluster binding Binding to a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria. got7fsn_ti 4Fe-3S cluster binding pr 2015-02-24T17:07:23Z molecular_function owl:Class
GO:0051536 biolink:NamedThing iron-sulfur cluster binding Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. got7fsn_ti Fe/S binding|iron sulfur cluster binding|iron-sulphur cluster binding|iron sulphur cluster binding molecular_function owl:Class
GO:0072181 biolink:NamedThing mesonephric duct formation The developmental process pertaining to the initial formation of a mesonephric duct. A mesonephric duct is a tube that drains the mesonephros. got7fsn_ti Wolffian duct formation mah 2010-02-26T02:38:03Z biological_process owl:Class
GO:0072179 biolink:NamedThing nephric duct formation The developmental process pertaining to the initial formation of a nephric duct. A nephric duct is a tube that drains a primitive kidney. got7fsn_ti mah 2010-02-26T02:35:55Z biological_process owl:Class
GO:0005796 biolink:NamedThing Golgi lumen The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. got7fsn_ti cellular_component owl:Class
GO:0000248 biolink:NamedThing C-5 sterol desaturase activity Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+. got7fsn_ti sterol-C5-desaturase activity Reactome:R-HSA-195664|Reactome:R-HSA-6807053 molecular_function owl:Class
GO:0045778 biolink:NamedThing positive regulation of ossification Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. got7fsn_ti stimulation of ossification|up regulation of ossification|positive regulation of bone biosynthesis|up-regulation of ossification|positive regulation of bone formation|activation of ossification|upregulation of ossification biological_process owl:Class
GO:0002557 biolink:NamedThing histamine secretion by basophil The regulated release of histamine by a basophil or group of basophils. got7fsn_ti biological_process owl:Class
GO:0002441 biolink:NamedThing histamine secretion involved in inflammatory response The regulated release of histamine by a cell as part of an inflammatory response. got7fsn_ti histamine secretion involved in acute inflammatory response biological_process owl:Class
GO:0060074 biolink:NamedThing synapse maturation The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development. got7fsn_ti synaptic maturation biological_process owl:Class
GO:0042249 biolink:NamedThing establishment of planar polarity of embryonic epithelium Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates. got7fsn_ti biological_process owl:Class
GO:0032033 biolink:NamedThing myosin II light chain binding Binding to a light chain of a myosin II complex. got7fsn_ti molecular_function owl:Class
GO:0032027 biolink:NamedThing myosin light chain binding Binding to a light chain of a myosin complex. got7fsn_ti molecular_function owl:Class
GO:0008918 biolink:NamedThing lipopolysaccharide 3-alpha-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide. got7fsn_ti UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity|LPS 3-alpha-galactosyltransferase activity|UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity|lipopolysaccharide galactosyltransferase activity|lipopolysaccharide 1,3-galactosyltransferase activity|UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity|UDP-galactose:polysaccharide galactosyltransferase activity|uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity|uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity|lipopolysaccharide-alpha-1,3-D-galactosyltransferase EC:2.4.1.44|MetaCyc:2.4.1.44-RXN molecular_function owl:Class
GO:0042113 biolink:NamedThing B cell activation The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti B-cell activation|B-lymphocyte activation|B lymphocyte activation biological_process owl:Class
GO:0050130 biolink:NamedThing N-methyl-2-oxoglutaramate hydrolase activity Catalysis of the reaction: N-methyl-2-oxoglutaramate + H(2)O = 2-oxoglutarate + methylammonium. got7fsn_ti 5-hydroxy-N-methylpyroglutamate synthase activity|N-methyl-2-oxoglutaramate methylamidohydrolase activity RHEA:24108|EC:3.5.1.36|MetaCyc:N-METHYL-2-OXOGLUTARAMATE-HYDROLASE-RXN|KEGG_REACTION:R01587 molecular_function owl:Class
GO:0046871 biolink:NamedThing N-acetylgalactosamine binding Binding to N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, the n-acetyl derivative of galactosamine. got7fsn_ti N-acetylgalactosamine lectin molecular_function owl:Class
GO:0097367 biolink:NamedThing carbohydrate derivative binding Binding to a carbohydrate derivative. got7fsn_ti pr 2012-08-02T13:03:39Z molecular_function owl:Class
GO:0043005 biolink:NamedThing neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. got7fsn_ti neuron process|nerve fiber|neuronal cell projection|neuron protrusion|neurite NIF_Subcellular:sao867568886 cellular_component owl:Class
GO:0097693 biolink:NamedThing ocelloid Eye-like subcellular structure found in dinoflagellates (a large group of single-celled eukaryotes). Consists of subcellular analogues to a cornea, lens, iris, and retina. Ocelloids are built from pre-existing organelles, including a cornea-like layer made of mitochondria and a retinal body made of anastomosing plastids. got7fsn_ti pr 2015-11-13T14:27:01Z cellular_component owl:Class
GO:0043229 biolink:NamedThing intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0009715 biolink:NamedThing chalcone biosynthetic process The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives. got7fsn_ti chalcone synthesis|chalcone biosynthesis|chalcone formation|chalcone anabolism biological_process owl:Class
GO:0009699 biolink:NamedThing phenylpropanoid biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid. got7fsn_ti phenylpropanoid formation|phenylpropanoid synthesis|phenylpropanoid anabolism|phenylpropanoid biosynthesis biological_process owl:Class
GO:0001503 biolink:NamedThing ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. got7fsn_ti bone formation|bone biosynthesis|osteogenesis Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. Wikipedia:Ossification biological_process owl:Class
GO:0001114 biolink:NamedThing protein-DNA-RNA complex A macromolecular complex containing protein, DNA, and RNA molecules. got7fsn_ti krc 2010-12-03T02:09:38Z cellular_component owl:Class
GO:0006192 biolink:NamedThing IDP phosphorylation The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP. got7fsn_ti biological_process owl:Class
GO:0046707 biolink:NamedThing IDP metabolic process The chemical reactions and pathways involving IDP, inosine 5'-diphosphate. got7fsn_ti IDP metabolism biological_process owl:Class
GO:0102061 biolink:NamedThing endo-beta-bergamotene synthase activity Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-endo-beta-bergamotene + diphosphoric acid. got7fsn_ti endo-beta-bergamontene synthase activity|(2Z,6Z)-farnesyl diphosphate <=> (+)-endo-beta-bergamotene|(+)-endo-beta-bergamotene synthase ((2Z,6Z)-farnesyl diphosphate cyclizing) MetaCyc:RXN-10483|EC:4.2.3.53|RHEA:30467 molecular_function owl:Class
GO:0047836 biolink:NamedThing D-tryptophan N-malonyltransferase activity Catalysis of the reaction: D-tryptophan + malonyl-CoA = N(2)-malonyl-D-tryptophan + CoA + H(+). got7fsn_ti malonyl-CoA:D-tryptophan N-malonyltransferase activity EC:2.3.1.112|KEGG_REACTION:R02482|RHEA:23320|MetaCyc:D-TRYPTOPHAN-N-MALONYLTRANSFERASE-RXN molecular_function owl:Class
GO:0047442 biolink:NamedThing 17-alpha-hydroxyprogesterone aldolase activity Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione. got7fsn_ti 17alpha-hydroxyprogesterone acetaldehyde-lyase activity|C-17/C-20 lyase activity|17alpha-hydroxyprogesterone acetaldehyde-lyase (4-androstene-3,17-dione-forming)|17-alpha-hydroxyprogesterone acetaldehyde-lyase activity|17alpha-hydroxyprogesterone aldolase activity RHEA:14753|EC:4.1.2.30|MetaCyc:4.1.2.30-RXN molecular_function owl:Class
GO:0003410 biolink:NamedThing anterior rotation of the optic cup A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis. got7fsn_ti dph 2009-12-21T02:49:48Z biological_process owl:Class
GO:0019410 biolink:NamedThing aerobic respiration, using carbon monoxide as electron donor The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation. got7fsn_ti biological_process owl:Class
GO:0009060 biolink:NamedThing aerobic respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. got7fsn_ti Wikipedia:Cellular_respiration#Aerobic_respiration|MetaCyc:PWY-3781 biological_process owl:Class
GO:0030336 biolink:NamedThing negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. got7fsn_ti down-regulation of cell migration|inhibition of cell migration|down regulation of cell migration|downregulation of cell migration biological_process owl:Class
GO:0007065 biolink:NamedThing male meiosis sister chromatid cohesion The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male. got7fsn_ti biological_process owl:Class
GO:0051177 biolink:NamedThing meiotic sister chromatid cohesion The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis. got7fsn_ti biological_process owl:Class
GO:0045060 biolink:NamedThing negative thymic T cell selection The process of elimination of immature T cells in the thymus which react strongly with self-antigens. got7fsn_ti negative thymic T-cell selection|negative thymic T lymphocyte selection|negative thymic T-lymphocyte selection biological_process owl:Class
GO:0045061 biolink:NamedThing thymic T cell selection The process of T cell selection that occurs in the thymus. got7fsn_ti thymic T lymphocyte selection|thymic T-cell selection|thymic T-lymphocyte selection biological_process owl:Class
GO:0051075 biolink:NamedThing S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA. got7fsn_ti S-adenosyl methionine:tRNA ribosyltransferase-isomerase activity RHEA:32155|EC:2.4.99.17 molecular_function owl:Class
GO:0016757 biolink:NamedThing glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). got7fsn_ti transglycosylase activity|transferase activity, transferring other glycosyl groups|transferase activity, transferring glycosyl groups|transglycosidase activity GO:0016932 Reactome:R-HSA-6785565|EC:2.4.-.-|Reactome:R-HSA-5173005 molecular_function owl:Class
GO:1900099 biolink:NamedThing negative regulation of plasma cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of plasma cell differentiation. got7fsn_ti downregulation of plasma cell differentiation|inhibition of plasma cell development|downregulation of plasma cell development|down-regulation of plasma cell differentiation|inhibition of plasma cell differentiation|negative regulation of plasma cell development|down-regulation of plasma cell development|down regulation of plasma cell differentiation|down regulation of plasma cell development bf 2012-02-15T10:46:05Z biological_process owl:Class
GO:0002698 biolink:NamedThing negative regulation of immune effector process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process. got7fsn_ti down-regulation of immune effector process|downregulation of immune effector process|inhibition of immune effector process|down regulation of immune effector process biological_process owl:Class
GO:0036382 biolink:NamedThing flavin reductase (NADH) activity Catalysis of the reaction: reduced flavin + NAD+ = flavin + NADH + H+. got7fsn_ti flavin:NADH oxidoreductase activity|NADH-dependent flavin reductase activity bf 2013-05-23T11:23:09Z EC:1.5.1.36|MetaCyc:1.5.1.36-RXN|KEGG_REACTION:R09662|RHEA:31303 molecular_function owl:Class
GO:0017045 biolink:NamedThing corticotropin-releasing hormone activity The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary. got7fsn_ti adrenocorticotropin-releasing hormone Wikipedia:Corticotropin-releasing_hormone molecular_function owl:Class
GO:0007221 biolink:NamedThing positive regulation of transcription of Notch receptor target The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain. got7fsn_ti N receptor target transcription factor activation|Notch receptor target transcription factor activation biological_process owl:Class
GO:0045944 biolink:NamedThing positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter, global|up regulation of transcription from RNA polymerase II promoter|activation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|up-regulation of transcription from RNA polymerase II promoter|upregulation of global transcription from RNA polymerase II promoter|activation of global transcription from RNA polymerase II promoter|upregulation of transcription from RNA polymerase II promoter|positive regulation of transcription from Pol II promoter|stimulation of transcription from RNA polymerase II promoter|positive regulation of global transcription from Pol II promoter|up-regulation of global transcription from RNA polymerase II promoter|up regulation of global transcription from RNA polymerase II promoter|positive regulation of gene-specific transcription from RNA polymerase II promoter|stimulation of global transcription from RNA polymerase II promoter GO:0010552|GO:0045817 biological_process owl:Class
GO:0033889 biolink:NamedThing N-sulfoglucosamine-3-sulfatase activity Catalysis of the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin. got7fsn_ti N-sulfo-3-sulfoglucosamine 3-sulfohydrolase activity|chondroitinsulfatase activity MetaCyc:3.1.6.15-RXN|EC:3.1.6.15 molecular_function owl:Class
GO:0014854 biolink:NamedThing response to inactivity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus. got7fsn_ti biological_process owl:Class
GO:0042210 biolink:NamedThing octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter. got7fsn_ti catabolism of octamethylcyclotetrasiloxane to DMSD|octamethylcyclotetrasiloxane degradation to dimethylsilanediol|octamethylcyclotetrasiloxane breakdown to dimethylsilanediol|catabolic process of octamethylcyclotetrasiloxane to DMSD UM-BBD_pathwayID:osi biological_process owl:Class
GO:0018947 biolink:NamedThing anaerobic organosilicon metabolic process The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen. got7fsn_ti anaerobic organosilicone metabolism|anaerobic organosilicone metabolic process|anaerobic organosilicon metabolism UM-BBD_pathwayID:osi biological_process owl:Class
GO:0046454 biolink:NamedThing dimethylsilanediol metabolic process The chemical reactions and pathways involving dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products. got7fsn_ti dimethylsilanediol metabolism biological_process owl:Class
GO:0090613 biolink:NamedThing 5'-deoxyadenosine deaminase activity Catalysis of the reaction: 5'deoxyadenosine + H2O = 5'deoxyinosine + NH3. got7fsn_ti tb 2014-10-23T15:59:38Z RHEA:42892|EC:3.5.4.41 molecular_function owl:Class
GO:0017062 biolink:NamedThing respiratory chain complex III assembly The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents. got7fsn_ti complex III biogenesis|cytochrome bc(1) complex biogenesis|cytochrome bc(1) complex assembly|coenzyme Q and cytochrome c reductase complex biogenesis|complex III assembly|coenzyme Q and cytochrome c reductase complex assembly biological_process owl:Class
GO:0017004 biolink:NamedThing cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. got7fsn_ti cytochrome biogenesis biological_process owl:Class
GO:0048208 biolink:NamedThing COPII vesicle coating The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. got7fsn_ti COPII coating of ER-derived vesicle|COPII vesicle coat assembly|COPII vesicle coat formation biological_process owl:Class
GO:0070333 biolink:NamedThing alpha6-beta4 integrin-Shc-Grb2 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the adaptor proteins Shc and Grb2. got7fsn_ti ITGA6-ITGB4-SHC-GRB2 complex cellular_component owl:Class
GO:0036506 biolink:NamedThing maintenance of unfolded protein Maintaining a protein in an unfolded, soluble state. got7fsn_ti bf 2015-06-11T10:17:36Z biological_process owl:Class
GO:0031647 biolink:NamedThing regulation of protein stability Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. got7fsn_ti biological_process owl:Class
GO:0030884 biolink:NamedThing exogenous lipid antigen binding Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids). got7fsn_ti molecular_function owl:Class
GO:0030882 biolink:NamedThing lipid antigen binding Binding to a lipid antigen. got7fsn_ti molecular_function owl:Class
GO:0070699 biolink:NamedThing type II activin receptor binding Binding to a type II activin receptor. got7fsn_ti mah 2009-06-04T04:16:26Z molecular_function owl:Class
GO:0070697 biolink:NamedThing activin receptor binding Binding to an activin receptor. got7fsn_ti mah 2009-06-04T04:02:13Z molecular_function owl:Class
GO:0019100 biolink:NamedThing male germ-line sex determination The determination of sex and sexual phenotype in a male organism's germ line. got7fsn_ti biological_process owl:Class
GO:0030238 biolink:NamedThing male sex determination The specification of male sex of an individual organism. got7fsn_ti biological_process owl:Class
GO:0021944 biolink:NamedThing neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration. got7fsn_ti biological_process owl:Class
GO:0099134 biolink:NamedThing chimeric sorocarp development Development of a sorocarp formed by aggregation of cells with different genotypes. got7fsn_ti biological_process owl:Class
GO:0030587 biolink:NamedThing sorocarp development The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum. got7fsn_ti fruiting body development|fruiting body formation|sorocarp biosynthesis|sorocarp formation biological_process owl:Class
GO:0060206 biolink:NamedThing estrous cycle phase The progression of physiological phases, occurring in the endometrium during the estrous cycle that recur at regular intervals during the reproductive years. The estrous cycle is an ovulation cycle where the endometrium is resorbed if pregnancy does not occur. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0044848 biolink:NamedThing biological phase A distinct period or stage in a biological process or cycle. got7fsn_ti Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. jl 2014-07-16T13:12:40Z biological_process owl:Class
GO:0044114 biolink:NamedThing development of symbiont in host The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti development of symbiont in host intercellular space|development of symbiont in host vascular tissue This term partially replaces the obsolete term 'growth or development of symbiont in host ; GO:0044412'. See also 'biological process involved in interaction with host ; GO:0051701. jl 2009-07-30T03:39:25Z GO:0044122|GO:0044124 biological_process owl:Class
GO:0001994 biolink:NamedThing norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure. got7fsn_ti norepinephrine-epinephrine vasoconstriction during control of blood pressure|norepinephrine-epinephrine vasoconstriction during blood pressure regulation|noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure|norepinephrine-epinephrine vasoconstriction during blood pressure control biological_process owl:Class
GO:0005018 biolink:NamedThing platelet-derived growth factor alpha-receptor activity Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity. got7fsn_ti alphaPDGF receptor activity|PDGF alpha-receptor activity molecular_function owl:Class
GO:0005017 biolink:NamedThing platelet-derived growth factor-activated receptor activity Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti PDGFR activity|platelet-derived growth factor receptor activity|PDGF-activated receptor activity|PDGF receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand PDGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class
GO:0072649 biolink:NamedThing interferon-kappa production The appearance of interferon-kappa due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IFNK production|IFN-kappa production|interferon-kappa secretion Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072650 biological_process owl:Class
GO:0032606 biolink:NamedThing type I interferon production The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti type I interferon secretion|interferon type I production|type I interferon biosynthetic process|type I IFN production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072641|GO:0045351 biological_process owl:Class
GO:0035567 biolink:NamedThing non-canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin. got7fsn_ti non-canonical Wnt receptor signaling pathway|beta-catenin-independent Wnt receptor signaling pathway|non-canonical Wnt receptor signalling pathway|non-canonical Wnt-activated signaling pathway This term should only be used when Wnt receptor signaling occurs via a beta-catenin-independent route but the downstream effectors are unknown. If the downstream effectors are known, consider instead annotating to one of the children, or requesting a new term. bf 2010-07-23T02:26:01Z biological_process owl:Class
GO:0045302 biolink:NamedThing choloylglycine hydrolase activity Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine. got7fsn_ti 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase activity|choloyltaurine hydrolase activity|glycocholase activity|bile salt hydrolase activity RHEA:19353|MetaCyc:CHOLOYLGLYCINE-HYDROLASE-RXN|EC:3.5.1.24 molecular_function owl:Class
GO:0015341 biolink:NamedThing zinc efflux active transmembrane transporter activity Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force. got7fsn_ti zinc efflux permease activity molecular_function owl:Class
GO:0022883 biolink:NamedThing zinc efflux transmembrane transporter activity Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti zinc efflux permease activity molecular_function owl:Class
GO:0102614 biolink:NamedThing germacrene A acid 8beta-hydroxylase activity Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + NADPH + O2 + H+ <=> 8beta-hydroxy-germacra-1(10),4,11(13)-trien-12-oate + NADP + H2O. got7fsn_ti MetaCyc:RXN-15460 molecular_function owl:Class
GO:0018217 biolink:NamedThing peptidyl-aspartic acid phosphorylation The phosphorylation of peptidyl-aspartic acid. got7fsn_ti biological_process owl:Class
GO:0018197 biolink:NamedThing peptidyl-aspartic acid modification The modification of peptidyl-aspartic acid. got7fsn_ti biological_process owl:Class
GO:1903053 biolink:NamedThing regulation of extracellular matrix organization Any process that modulates the frequency, rate or extent of extracellular matrix organization. got7fsn_ti regulation of extracellular matrix organization and biogenesis|regulation of extracellular matrix organisation rl 2014-05-23T17:15:41Z biological_process owl:Class
GO:0016668 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor|oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor|oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor|oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor GO:0016654 EC:1.8.1.- molecular_function owl:Class
GO:0061061 biolink:NamedThing muscle structure development The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms. got7fsn_ti dph 2010-03-09T08:55:14Z biological_process owl:Class
GO:0071881 biolink:NamedThing adenylate cyclase-inhibiting adrenergic receptor signaling pathway The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti adrenergic receptor, adenylyl cyclase inhibiting pathway|inhibition of adenylate cyclase activity by adrenergic receptor signalling pathway|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|adrenergic receptor, adenylate cyclase inhibiting pathway mah 2010-09-13T04:22:53Z biological_process owl:Class
GO:0048700 biolink:NamedThing acquisition of desiccation tolerance in seed The process in which a seed acquires tolerance to severe drying, before entering into a dry, either dormant or quiescent state. got7fsn_ti acquisition of desiccation tolerance biological_process owl:Class
GO:0097439 biolink:NamedThing acquisition of desiccation tolerance The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state. got7fsn_ti pr 2012-12-05T15:09:52Z biological_process owl:Class
GO:0008673 biolink:NamedThing 2-dehydro-3-deoxygluconokinase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+). got7fsn_ti ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity|2-keto-3-deoxygluconokinase activity|KDG kinase activity|2-keto-3-deoxy-D-gluconic acid kinase activity|2-keto-3-deoxygluconate kinase activity|3-deoxy-2-oxo-D-gluconate kinase activity|ketodeoxygluconokinase activity|2-keto-3-deoxygluconokinase (phosphorylating) KEGG_REACTION:R01541|MetaCyc:DEOXYGLUCONOKIN-RXN|EC:2.7.1.45|RHEA:14797 molecular_function owl:Class
GO:0071493 biolink:NamedThing cellular response to UV-B Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. got7fsn_ti cellular response to UVB light stimulus|cellular response to UV-B light stimulus|cellular response to medium wave ultraviolet radiation stimulus|cellular response to UV-B radiation stimulus|cellular response to UVB radiation stimulus|cellular response to medium wave ultraviolet light stimulus mah 2009-12-18T02:21:56Z biological_process owl:Class
GO:0080171 biolink:NamedThing lytic vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole. got7fsn_ti lytic vacuole biogenesis|lytic vacuole organization and biogenesis|lytic vacuole organisation|lytic vacuolar assembly dhl 2011-04-25T04:40:46Z biological_process owl:Class
GO:0065007 biolink:NamedThing biological regulation Any process that modulates a measurable attribute of any biological process, quality or function. got7fsn_ti regulation biological_process owl:Class
GO:0120306 biolink:NamedThing cellular response to actin cytoskeletal stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of perturbations or damage to the actin cytoskeleton. got7fsn_ti cellular response to latrunculin B|cellular response to actin cytoskeleton stress|response to latrunculin A|response to latrunculin B|cellular response to latrunculin A https://github.com/geneontology/go-ontology/issues/20189 krc 2021-02-12T21:44:37Z GO:1904805|GO:1903956|GO:1904804|GO:1903957 biological_process owl:Class
GO:0071565 biolink:NamedThing nBAF complex A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. got7fsn_ti mah 2010-01-20T03:41:19Z cellular_component owl:Class
GO:0016298 biolink:NamedThing lipase activity Catalysis of the hydrolysis of a lipid or phospholipid. got7fsn_ti EC:3.1.1.-|Reactome:R-HSA-163402|Reactome:R-HSA-163432 molecular_function owl:Class
GO:0097395 biolink:NamedThing response to interleukin-32 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus. got7fsn_ti response to IL-32 pr 2012-10-23T13:21:16Z biological_process owl:Class
GO:0010588 biolink:NamedThing cotyledon vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants. got7fsn_ti biological_process owl:Class
GO:0010051 biolink:NamedThing xylem and phloem pattern formation The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana. got7fsn_ti vascular tissue pattern formation biological_process owl:Class
GO:0061368 biolink:NamedThing behavioral response to formalin induced pain Any process that results in a change in the behaviour of an organism as a result of a formalin pain stimulus. got7fsn_ti dph 2010-10-21T03:29:48Z biological_process owl:Class
GO:0098874 biolink:NamedThing spike train A series of sequential, propagated action potentials occurring in a single cell. got7fsn_ti spike-train|burst of action potentials GO:0099603 biological_process owl:Class
GO:0035965 biolink:NamedThing cardiolipin acyl-chain remodeling Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids. got7fsn_ti cardiolipin maturation|cardiolipin acyl-chain remodelling|diphosphatidylglycerol remodeling bf 2011-08-03T11:17:49Z biological_process owl:Class
GO:0032048 biolink:NamedThing cardiolipin metabolic process The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. got7fsn_ti diphosphatidylglycerol metabolism|diphosphatidylglycerol metabolic process|cardiolipin metabolism biological_process owl:Class
GO:0004486 biolink:NamedThing methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+. got7fsn_ti 5,10-methylene-THF dehydrogenase activity|N5,N10-methylenetetrahydrofolate dehydrogenase activity EC:1.5.1.5|Reactome:R-HSA-200644|Reactome:R-HSA-200718 molecular_function owl:Class
GO:0010304 biolink:NamedThing PSII associated light-harvesting complex II catabolic process The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II. got7fsn_ti LHCII catabolism biological_process owl:Class
GO:0030754 biolink:NamedThing apigenin 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone. got7fsn_ti flavonoid methyltransferase activity|S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity|flavonoid O-methyltransferase activity RHEA:20429|MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN|EC:2.1.1.75 molecular_function owl:Class
GO:0034501 biolink:NamedThing protein localization to kinetochore Any process in which a protein is transported to, or maintained at, the kinetochore. got7fsn_ti protein localisation to kinetochore|condensin localization to kinetochore biological_process owl:Class
GO:0034502 biolink:NamedThing protein localization to chromosome Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. got7fsn_ti condensin localization to chromosome|protein localisation to chromosome biological_process owl:Class
GO:0031728 biolink:NamedThing CCR3 chemokine receptor binding Binding to a CCR3 chemokine receptor. got7fsn_ti CCR3 chemokine receptor ligand|eosinophil eotaxin receptor binding molecular_function owl:Class
GO:0071785 biolink:NamedThing endoplasmic reticulum cisternal network maintenance The organization process that preserves the endoplasmic reticulum (ER) cisternal network in a stable functional or structural state. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. got7fsn_ti ER cisternal network maintenance mah 2010-09-01T01:52:26Z biological_process owl:Class
GO:0071783 biolink:NamedThing endoplasmic reticulum cisternal network organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. got7fsn_ti ER cisternal network organization|ER cisternal network organisation|endoplasmic reticulum cisternal network organisation mah 2010-09-01T01:47:28Z biological_process owl:Class
GO:0034821 biolink:NamedThing citronellol dehydrogenase activity Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+. got7fsn_ti UM-BBD_reactionID:r1155 molecular_function owl:Class
GO:0048439 biolink:NamedThing flower morphogenesis The process in which the anatomical structures of the flower are generated and organized. got7fsn_ti GO:0048411 biological_process owl:Class
GO:1902929 biolink:NamedThing plasma membrane of growing cell tip Any plasma membrane part that is part of a growing cell tip. got7fsn_ti plasma membrane part of growing cell tip|growing cell tip plasma membrane part|plasma membrane part of growing cell end mah 2014-04-22T16:02:06Z cellular_component owl:Class
GO:0031520 biolink:NamedThing plasma membrane of cell tip The portion of the plasma membrane surrounding the cell tip. got7fsn_ti 'plasma membrane, cell tip' cellular_component owl:Class
GO:1990248 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to DNA damage Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage. got7fsn_ti pg 2013-12-04T13:28:04Z biological_process owl:Class
GO:0052593 biolink:NamedThing tryptamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: tryptamine + H2O + O2 = NH3 + indole acetaldehyde + hydrogen peroxide + H+. got7fsn_ti KEGG_REACTION:R02173|EC:1.4.3.21|MetaCyc:RXN-1401 molecular_function owl:Class
GO:0044465 biolink:NamedThing modulation of sensory perception of pain in other organism A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism. got7fsn_ti regulation of sensory perception of pain in another organism jl 2012-01-12T03:14:19Z biological_process owl:Class
GO:0034861 biolink:NamedThing benzothiazole-2-sulfonate hydrolase activity Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-. got7fsn_ti UM-BBD_reactionID:r1290|EC:3.13.1.- molecular_function owl:Class
GO:0046508 biolink:NamedThing hydrolase activity, acting on carbon-sulfur bonds Catalysis of the hydrolysis of any carbon-sulfur bond, C-S. got7fsn_ti hydrolase activity, acting on carbon-sulphur bonds EC:3.13.-.- molecular_function owl:Class
GO:0034794 biolink:NamedThing cyclopropanecarboxyl-CoA decyclase activity Catalysis of the reaction: cyclopropanecarboxyl-CoA = crotonoyl-CoA. got7fsn_ti EC:5.5.1.-|UM-BBD_reactionID:r1057 molecular_function owl:Class
GO:0016872 biolink:NamedThing intramolecular lyase activity The catalysis of certain rearrangements of a molecule to break or form a ring. got7fsn_ti EC:5.5.1.- molecular_function owl:Class
GO:0016132 biolink:NamedThing brassinosteroid biosynthetic process The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. got7fsn_ti brassinosteroid anabolism|brassinosteroid formation|brassinosteroid synthesis|brassinosteroid biosynthesis MetaCyc:PWY-699|MetaCyc:PWY-2582 biological_process owl:Class
GO:0042446 biolink:NamedThing hormone biosynthetic process The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. got7fsn_ti hormone anabolism|hormone biosynthesis|hormone synthesis|hormone formation biological_process owl:Class
GO:0034059 biolink:NamedThing response to anoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%. got7fsn_ti response to anoxic stress Note that this term should not be confused with 'response to hypoxia ; GO:0001666'. biological_process owl:Class
GO:0018258 biolink:NamedThing protein O-linked glycosylation via hydroxyproline The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline. got7fsn_ti protein amino acid O-linked glycosylation via hydroxyproline RESID:AA0212 biological_process owl:Class
GO:0045332 biolink:NamedThing phospholipid translocation The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. got7fsn_ti flippase|phospholipid scrambling Note that this term describes the transbilayer motion of individual phospholipid molecules, and should not be confused with 'phospholipid scrambling ; GO:0017121'. biological_process owl:Class
GO:0097035 biolink:NamedThing regulation of membrane lipid distribution Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane. got7fsn_ti pr 2011-04-08T02:01:19Z biological_process owl:Class
GO:0047636 biolink:NamedThing alanopine dehydrogenase activity Catalysis of the reaction: 2,2'-iminodipropanoate + H(2)O + NAD(+) = L-alanine + H(+) + NADH + pyruvate. got7fsn_ti alanopine:NAD oxidoreductase activity|ADH|2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)|alanopine: NAD oxidoreductase activity|alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase activity|meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase activity|ALPDH MetaCyc:ALANOPINE-DEHYDROGENASE-RXN|RHEA:17589|KEGG_REACTION:R00398|EC:1.5.1.17 molecular_function owl:Class
GO:0033823 biolink:NamedThing procollagen glucosyltransferase activity Catalysis of the reaction: UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen. got7fsn_ti collagen glucosyltransferase activity|UDP-glucose-collagenglucosyltransferase activity|collagen hydroxylysyl glucosyltransferase activity|uridine diphosphoglucose-collagen glucosyltransferase activity|galactosylhydroxylysyl glucosyltransferase activity|galactosylhydroxylysine glucosyltransferase activity|galactosylhydroxylysine-glucosyltransferase activity|UDP-glucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity|UDPglucose:5-(D-galactosyloxy)-L-lysine-procollagen D-glucosyltransferase activity Reactome:R-HSA-1981157|MetaCyc:PROCOLLAGEN-GLUCOSYLTRANSFERASE-RXN|RHEA:12576|EC:2.4.1.66 molecular_function owl:Class
GO:1990477 biolink:NamedThing MTREC complex Protein complex formed by an RNA binding protein Red1, an RNA helicase Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2. This complex is required for the recruitment of the nuclear exosome to Mmi1 nuclear focus. It is likely related to the human CBCN complex. This complex is also known as RNA silencing (NURS) complex. got7fsn_ti Mtl1-Red1 core complex|PAXT complex|NURS complex https://github.com/geneontology/go-ontology/issues/21207|https://github.com/geneontology/go-ontology/issues/19059 An example of this is the complex formed by Red1 and Mtl1 in S. pombe (UniProt symbols Q9UTR8 and O13799 respectively) in PMID:24210919 (inferred from direct assay). mah 2014-03-24T13:30:52Z GO:1990345 cellular_component owl:Class
GO:0047401 biolink:NamedThing trithionate hydrolase activity Catalysis of the reaction: H(2)O + trithionate = H(+) + sulfate + thiosulfate. got7fsn_ti trithionate thiosulfohydrolase activity MetaCyc:3.12.1.1-RXN|EC:3.12.1.1|RHEA:21884|KEGG_REACTION:R01930 molecular_function owl:Class
GO:0016828 biolink:NamedThing hydrolase activity, acting on acid sulfur-sulfur bonds Catalysis of the hydrolysis of any acid sulfur-sulfur bond. got7fsn_ti hydrolase activity, acting on acid sulphur-sulphur bonds EC:3.12.-.- molecular_function owl:Class
GO:0007391 biolink:NamedThing dorsal closure The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. got7fsn_ti biological_process owl:Class
GO:0035588 biolink:NamedThing G protein-coupled purinergic receptor signaling pathway The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. got7fsn_ti G-protein coupled purinergic receptor signaling pathway|G-protein coupled purinergic receptor signalling pathway bf 2010-10-22T11:11:53Z biological_process owl:Class
GO:0030506 biolink:NamedThing ankyrin binding Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. got7fsn_ti molecular_function owl:Class
GO:0060006 biolink:NamedThing angular vestibuloocular reflex A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness. got7fsn_ti biological_process owl:Class
GO:0021872 biolink:NamedThing forebrain generation of neurons The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons. got7fsn_ti generation of neurons in forebrain biological_process owl:Class
GO:0048699 biolink:NamedThing generation of neurons The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons. got7fsn_ti neuron generation biological_process owl:Class
GO:0016257 biolink:NamedThing N-glycan processing to secreted and cell-surface N-glycans The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus. got7fsn_ti biological_process owl:Class
GO:0089701 biolink:NamedThing U2AF complex A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point. got7fsn_ti U2 accessory factor|U2AF cellular_component owl:Class
GO:0120092 biolink:NamedThing crotonyl-CoA hydratase activity Catalysis of the reaction: Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. got7fsn_ti krc 2017-08-22T20:13:55Z RHEA:45584 molecular_function owl:Class
GO:0008984 biolink:NamedThing protein-glutamate methylesterase activity Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. got7fsn_ti methylesterase CheB activity|protein-L-glutamate-O5-methyl-ester acylhydrolase activity|protein-L-glutamate-5-O-methyl-ester acylhydrolase activity|CheB methylesterase activity|methyl-accepting chemotaxis protein methyl-esterase activity|chemotaxis-specific methylesterase activity MetaCyc:MCPMETEST-RXN|EC:3.1.1.61|RHEA:23236|RESID:AA0072 molecular_function owl:Class
GO:0070046 biolink:NamedThing synaptobrevin 2-SNAP-25-syntaxin-3 complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 3 (or orthologs thereof). got7fsn_ti Stx3-Snap25-Vamp2 complex|SNARE complex (Stx3, Snap25, Vamp2) cellular_component owl:Class
GO:0033937 biolink:NamedThing 3-deoxy-2-octulosonidase activity Catalysis of the endohydrolysis of the beta-ketopyranosidic linkages of 3-deoxy-D-manno-2-octulosonate in capsular polysaccharides. got7fsn_ti octulosylono hydrolase activity|capsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity|octulofuranosylono hydrolase activity|2-keto-3-deoxyoctonate hydrolase activity|octulopyranosylonohydrolase activity EC:3.2.1.124|MetaCyc:3.2.1.124-RXN molecular_function owl:Class
GO:0102905 biolink:NamedThing valencene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (+)-valencene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8608|RHEA:29511|EC:4.2.3.73 molecular_function owl:Class
GO:0070392 biolink:NamedThing detection of lipoteichoic acid The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. got7fsn_ti detection of LTA biological_process owl:Class
GO:0032490 biolink:NamedThing detection of molecule of bacterial origin The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal. got7fsn_ti detection of bacterium associated molecule|detection of bacterial associated molecule|detection of bacteria associated molecule biological_process owl:Class
GO:0009880 biolink:NamedThing embryonic pattern specification The process that results in the patterns of cell differentiation that will arise in an embryo. got7fsn_ti embryonic pattern biosynthesis|embryonic pattern formation|ventral/lateral system biological_process owl:Class
GO:0007389 biolink:NamedThing pattern specification process Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate. got7fsn_ti pattern formation|pattern biosynthesis biological_process owl:Class
GO:0140463 biolink:NamedThing chromatin-protein adaptor The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex. got7fsn_ti chromatin adaptor|chromatin adaptor activity|chromatin recruitment|chromatin receptor|protein-chromatin adaptor activity https://github.com/geneontology/go-ontology/issues/17064 pg 2020-05-08T12:31:39Z molecular_function owl:Class
GO:0051737 biolink:NamedThing GTP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephospho-DNA = GDP + 5'-phospho-DNA. got7fsn_ti GTP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity|GTP-dependent polydeoxyribonucleotide kinase activity|GTP-dependent DNA 5'-hydroxyl-kinase activity|GTP-dependent polynucleotide 5'-hydroxyl-kinase activity|GTP-dependent DNA kinase activity molecular_function owl:Class
GO:0051733 biolink:NamedThing polydeoxyribonucleotide kinase activity Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA. got7fsn_ti DNA kinase activity|DNA 5'-hydroxyl kinase activity molecular_function owl:Class
GO:0051110 biolink:NamedThing peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine). got7fsn_ti RESID:AA0372 biological_process owl:Class
GO:0051114 biolink:NamedThing peptidyl-histidine uridylylation The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine). got7fsn_ti RESID:AA0372 biological_process owl:Class
GO:0035570 biolink:NamedThing N-terminal peptidyl-serine methylation The methylation of the N-terminal serine of proteins. got7fsn_ti bf 2010-08-06T01:58:11Z biological_process owl:Class
GO:0014850 biolink:NamedThing response to muscle activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. got7fsn_ti biological_process owl:Class
GO:0014823 biolink:NamedThing response to activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. got7fsn_ti response to exercise biological_process owl:Class
GO:0034074 biolink:NamedThing marneral synthase activity Catalysis of the reaction: oxidosqualene = marneral. got7fsn_ti MetaCyc:RXN-9664|RHEA:31875 molecular_function owl:Class
GO:0031559 biolink:NamedThing oxidosqualene cyclase activity Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene. got7fsn_ti 2,3-oxidosqualene cyclase activity Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'. molecular_function owl:Class
GO:0018654 biolink:NamedThing 2-hydroxy-phenylacetate hydroxylase activity Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate. got7fsn_ti UM-BBD_reactionID:r0252|EC:1.14.13.- molecular_function owl:Class
GO:0044175 biolink:NamedThing host cell endosome membrane The lipid bilayer surrounding a host cell endosome. got7fsn_ti host endosome membrane jl 2009-09-04T03:04:04Z cellular_component owl:Class
GO:0102163 biolink:NamedThing 3-hydroxyacyl-CoA-acyl carrier protein transferase activity Catalysis of the reaction: coenzyme A + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a (3R)-3-hydroxyacyl-CoA + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-11785 molecular_function owl:Class
GO:0010668 biolink:NamedThing ectodermal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0060977 biolink:NamedThing coronary vasculature morphogenesis The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood. got7fsn_ti cardiac vasculature morphogenesis|cardiac blood vessel morphogenesis|heart vasculature morphogenesis|coronary blood vessel morphogenesis|heart blood vessel morphogenesis dph 2009-10-06T12:28:23Z biological_process owl:Class
GO:0048514 biolink:NamedThing blood vessel morphogenesis The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. got7fsn_ti biological_process owl:Class
GO:0097578 biolink:NamedThing sequestering of copper ion The process of binding or confining copper ions such that they are separated from other components of a biological system. got7fsn_ti copper ion retention|copper ion storage|sequestration of copper ion|copper ion sequestration|retention of copper ion|storage of copper ion|copper ion sequestering pr 2014-02-28T11:15:02Z biological_process owl:Class
GO:0006878 biolink:NamedThing cellular copper ion homeostasis Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell. got7fsn_ti copper homeostasis biological_process owl:Class
GO:0004367 biolink:NamedThing glycerol-3-phosphate dehydrogenase [NAD+] activity Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. got7fsn_ti NAD-alpha-glycerophosphate dehydrogenase activity|hydroglycerophosphate dehydrogenase activity|L-glycerol phosphate dehydrogenase activity|alpha-glycerol phosphate dehydrogenase (NAD) activity|L-alpha-glycerophosphate dehydrogenase activity|alpha-glycerophosphate dehydrogenase (NAD) activity|NADH-dihydroxyacetone phosphate reductase activity|glycerol phosphate dehydrogenase (NAD) activity|L-glycerophosphate dehydrogenase activity|NAD-L-glycerol-3-phosphate dehydrogenase activity|glycerol-3-phosphate dehydrogenase (NAD) activity|L-alpha-glycerol phosphate dehydrogenase activity|NAD-linked glycerol 3-phosphate dehydrogenase activity|NAD-dependent glycerol-3-phosphate dehydrogenase activity|glycerol 1-phosphate dehydrogenase activity|NAD-dependent glycerol phosphate dehydrogenase activity|glycerophosphate dehydrogenase (NAD) activity EC:1.1.1.8|MetaCyc:1.1.1.8-RXN|KEGG_REACTION:R00842|RHEA:11092|Reactome:R-HSA-75889 molecular_function owl:Class
GO:0047952 biolink:NamedThing glycerol-3-phosphate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+. got7fsn_ti L-glycerol-3-phosphate:NAD(P) oxidoreductase activity|sn-glycerol-3-phosphate:NAD(P)+ 2-oxidoreductase activity|glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)) activity|glycerol-3-phosphate dehydrogenase (NAD(P)+) activity bf 2013-09-30T10:37:46Z GO:0036439 KEGG_REACTION:R00844|MetaCyc:GLYC3PDEHYDROGBIOSYN-RXN|EC:1.1.1.94 molecular_function owl:Class
GO:0034011 biolink:NamedThing L-cysteate sulfo-lyase activity Catalysis of the reaction: L-cysteate + H(2)O = NH(4)(+) + pyruvate + sulfite. got7fsn_ti L-cysteate bisulfite-lyase (deaminating; pyruvate-forming) activity|CuyA|L-cysteate sulfo-lyase (deaminating) activity RHEA:13441|MetaCyc:4.4.1.25-RXN|KEGG_REACTION:R07634|EC:4.4.1.25 molecular_function owl:Class
GO:0120054 biolink:NamedThing intestinal motility Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth). got7fsn_ti krc 2017-06-13T20:42:24Z biological_process owl:Class
GO:0046899 biolink:NamedThing nucleoside triphosphate adenylate kinase activity Catalysis of the reaction: nucleoside triphosphate + AMP = nucleoside diphosphate + ADP. got7fsn_ti nucleoside-triphosphate-adenylate kinase activity|isozyme 3 of adenylate kinase activity|nucleoside-triphosphate:AMP phosphotransferase activity|GTP:AMP phosphotransferase|guanosine triphosphate-adenylate kinase|nucleoside triphosphate-adenosine monophosphate transphosphorylase activity EC:2.7.4.10|MetaCyc:2.7.4.10-RXN|Reactome:R-HSA-1008248|RHEA:13749 molecular_function owl:Class
GO:0031917 biolink:NamedThing negative regulation of synaptic metaplasticity A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. got7fsn_ti inhibition of synaptic metaplasticity|down regulation of synaptic metaplasticity|downregulation of synaptic metaplasticity|down-regulation of synaptic metaplasticity biological_process owl:Class
GO:0031914 biolink:NamedThing negative regulation of synaptic plasticity A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. got7fsn_ti inhibition of synaptic plasticity|down-regulation of synaptic plasticity|downregulation of synaptic plasticity|down regulation of synaptic plasticity biological_process owl:Class
GO:0080188 biolink:NamedThing gene silencing by RNA-directed DNA methylation A small RNA-based epigenetic gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism. got7fsn_ti RNA-directed DNA methylation|RdDM https://github.com/geneontology/go-ontology/issues/19328|https://github.com/geneontology/go-ontology/issues/22047 This process has been shown in plants and in yeasts, but so far has not been detected in vertebrates, organisms that lack RNA-dependent RNA polymerase. dhl 2012-05-22T02:22:50Z biological_process owl:Class
GO:0005801 biolink:NamedThing cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. got7fsn_ti cis Golgi network|Golgi cis face|forming face|cis face|Golgi cis-face The CGN is not considered part of the Golgi apparatus but is a separate organelle. NIF_Subcellular:sao632188024 cellular_component owl:Class
GO:1990475 biolink:NamedThing synaptic vesicle, recycling pool A synaptic vesicle belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state. got7fsn_ti recycling pool of synaptic vesicles pr 2014-09-02T09:08:22Z cellular_component owl:Class
GO:0008021 biolink:NamedThing synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. got7fsn_ti docked vesicle This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles. Wikipedia:Synaptic_vesicle|NIF_Subcellular:sao1071221672 cellular_component owl:Class
GO:0106124 biolink:NamedThing reservosome lumen The volume enclosed by the membranes of a reservosome. got7fsn_ti hjd 2018-05-03T17:54:46Z cellular_component owl:Class
GO:0019243 biolink:NamedThing methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step. got7fsn_ti methylglyoxal breakdown to D-lactate|glyoxalase system|D-lactate biosynthetic process from methylglyoxal|methylglyoxal detoxification|methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione|D-lactate biosynthesis from methylglyoxal|methylglyoxal degradation to D-lactate MetaCyc:PWY-5386 biological_process owl:Class
GO:0061727 biolink:NamedThing methylglyoxal catabolic process to lactate The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate. got7fsn_ti dph 2015-07-21T17:25:57Z biological_process owl:Class
GO:0048876 biolink:NamedThing chemical homeostasis within retina Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina. got7fsn_ti biological_process owl:Class
GO:0001895 biolink:NamedThing retina homeostasis A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. got7fsn_ti biological_process owl:Class
GO:0003067 biolink:NamedThing circadian regulation of systemic arterial blood pressure by hormone The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. got7fsn_ti biological_process owl:Class
GO:0048445 biolink:NamedThing carpel morphogenesis The process in which the anatomical structures of the carpel are generated and organized. got7fsn_ti GO:0048430 biological_process owl:Class
GO:0031424 biolink:NamedThing keratinization The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns. got7fsn_ti biological_process owl:Class
GO:0085029 biolink:NamedThing extracellular matrix assembly The aggregation, arrangement and bonding together of the extracellular matrix. got7fsn_ti jl 2010-07-14T12:52:49Z biological_process owl:Class
GO:0030198 biolink:NamedThing extracellular matrix organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. got7fsn_ti extracellular matrix organisation|extracellular matrix organization and biogenesis biological_process owl:Class
GO:1990937 biolink:NamedThing xylan acetylation The addition of one or more acetyl groups to a xylan molecule. got7fsn_ti tb 2016-03-30T22:10:22Z biological_process owl:Class
GO:0045491 biolink:NamedThing xylan metabolic process The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone. got7fsn_ti xylan metabolism biological_process owl:Class
GO:0048626 biolink:NamedThing myoblast fate specification The process in which a cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0035667 biolink:NamedThing TRIF-dependent toll-like receptor 4 signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. got7fsn_ti Toll/IL-1 receptor (TIR) domain-containing adaptor-dependent TLR4 signaling pathway|TRIF-dependent TLR4 signaling pathway|TRIF-dependent toll-like receptor 4 signalling pathway bf 2011-02-01T02:37:25Z biological_process owl:Class
GO:0050116 biolink:NamedThing N,N-dimethylformamidase activity Catalysis of the reaction: N,N-dimethylformamide + H(2)O = dimethylamine + formate. got7fsn_ti dimethylformamidase activity|N,N-dimethylformamide amidohydrolase activity|DMFase activity KEGG_REACTION:R02509|RHEA:19517|MetaCyc:NN-DIMETHYLFORMAMIDASE-RXN|EC:3.5.1.56 molecular_function owl:Class
GO:0102393 biolink:NamedThing decanoyl-[acp] 2-dehydrogenase activity Catalysis of the reaction: FAD + H+ + a decanoyl-HmqF protein <=> FADH2(2-) + a 2,3-dehydro-decanoyl-HmqF. got7fsn_ti MetaCyc:RXN-13624 molecular_function owl:Class
GO:0052890 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin. got7fsn_ti EC:1.3.8.- molecular_function owl:Class
GO:0043822 biolink:NamedThing ribonuclease M5 activity Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor. got7fsn_ti 5S ribosomal RNA maturation endonuclease activity|RNase M5 activity|5S ribosomal maturation nuclease activity EC:3.1.26.8|MetaCyc:3.1.26.8-RXN molecular_function owl:Class
GO:0060306 biolink:NamedThing regulation of membrane repolarization Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential, usually from positive to negative. got7fsn_ti biological_process owl:Class
GO:0017131 biolink:NamedThing uridine-rich cytoplasmic polyadenylylation element binding Binding to a U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation. got7fsn_ti uridine-rich cytoplasmic polyadenylation element binding|U-rich CPE binding molecular_function owl:Class
GO:0008187 biolink:NamedThing poly-pyrimidine tract binding Binding to a stretch of pyrimidines (cytosine or uracil) in an RNA molecule. got7fsn_ti molecular_function owl:Class
GO:1900575 biolink:NamedThing emodin biosynthetic process The chemical reactions and pathways resulting in the formation of emodin. got7fsn_ti emodin synthesis|emodin formation|emodin anabolism|emodin biosynthesis di 2012-05-15T06:42:14Z biological_process owl:Class
GO:0060438 biolink:NamedThing trachea development The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches. got7fsn_ti biological_process owl:Class
GO:0031530 biolink:NamedThing gonadotropin-releasing hormone receptor binding Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. got7fsn_ti gonadotrophin-releasing hormone receptor binding|GnRH receptor binding molecular_function owl:Class
GO:0051428 biolink:NamedThing peptide hormone receptor binding Binding to a receptor for a peptide hormone. got7fsn_ti polypeptide hormone receptor binding molecular_function owl:Class
GO:0047439 biolink:NamedThing 3-deoxy-D-manno-octulosonate aldolase activity Catalysis of the reaction: 3-deoxy-D-manno-octulosonate = D-arabinose + pyruvate. got7fsn_ti 3-deoxy-D-manno-octulosonate D-arabinose-lyase activity|KDOaldolase activity|3-deoxy-D-manno-octulosonic aldolase activity|3-deoxy-D-manno-octulosonate D-arabinose-lyase (pyruvate-forming)|3-deoxyoctulosonic aldolase activity|2-keto-3-deoxyoctonic aldolase activity|2-keto-3-deoxyoctonate aldolase activity MetaCyc:4.1.2.23-RXN|KEGG_REACTION:R01576|EC:4.1.2.23|RHEA:23340 molecular_function owl:Class
GO:0019681 biolink:NamedThing acetyl-CoA assimilation pathway The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell. got7fsn_ti acetyl-CoA catabolism to alpha-ketoglutarate|acetyl-CoA catabolic process to alpha-oxoglutarate|acetyl-CoA catabolism to alpha-oxoglutarate|acetyl-CoA catabolism to 2-ketoglutarate|acetyl-CoA catabolism to 2-oxoglutarate|acetyl-CoA catabolic process to 2-oxoglutarate|acetyl-CoA catabolic process to alpha-ketoglutarate|acetyl-CoA catabolic process to 2-ketoglutarate biological_process owl:Class
GO:0006103 biolink:NamedThing 2-oxoglutarate metabolic process The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism. got7fsn_ti alpha-oxoglutarate metabolism|2-ketoglutarate metabolism|2-oxoglutarate metabolism|alpha-ketoglutarate metabolism|alpha-ketoglutarate metabolic process|alpha-oxoglutarate metabolic process|2-ketoglutarate metabolic process biological_process owl:Class
GO:0080176 biolink:NamedThing xyloglucan 1,6-alpha-xylosidase activity Catalysis of the hydrolysis of xyloglucan side chains so as to remove unsubstituted D-xylose residues attached to the glucose located at the non-reducing terminus. got7fsn_ti dhl 2011-04-28T04:08:39Z molecular_function owl:Class
GO:0090559 biolink:NamedThing regulation of membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane. got7fsn_ti tb 2014-03-27T13:48:35Z biological_process owl:Class
GO:0044057 biolink:NamedThing regulation of system process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system. got7fsn_ti biological_process owl:Class
GO:0071955 biolink:NamedThing recycling endosome to Golgi transport The directed movement of substances from recycling endosomes to the Golgi. got7fsn_ti mah 2010-10-08T01:19:00Z biological_process owl:Class
GO:0042147 biolink:NamedThing retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. got7fsn_ti retrograde (endosome to Golgi) transport biological_process owl:Class
GO:0006571 biolink:NamedThing tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. got7fsn_ti tyrosine anabolism|tyrosine formation|tyrosine synthesis|tyrosine biosynthesis https://github.com/geneontology/go-ontology/issues/20583 biological_process owl:Class
GO:0009095 biolink:NamedThing aromatic amino acid family biosynthetic process, prephenate pathway The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate. got7fsn_ti aromatic amino acid family formation, prephenate pathway|aromatic amino acid family biosynthetic process via prephenate|aromatic amino acid family anabolism, prephenate pathway|aromatic amino acid family biosynthetic process via prephenate(2-)|aromatic amino acid family synthesis, prephenate pathway biological_process owl:Class
GO:0052908 biolink:NamedThing 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA. got7fsn_ti S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase activity https://github.com/geneontology/go-ontology/issues/14459 EC:2.1.1.182|RHEA:19609|MetaCyc:RXN-11633 molecular_function owl:Class
GO:0060983 biolink:NamedThing epicardium-derived cardiac vascular smooth muscle cell differentiation The process in which a relatively unspecialized cell derived from the epicardium acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers. got7fsn_ti dph 2009-10-06T03:05:33Z biological_process owl:Class
GO:0060947 biolink:NamedThing cardiac vascular smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a cardiac vascular smooth muscle cell. A cardiac vascular smooth muscle cell covers the heart vasculature and lacks transverse striations in its constituent fibers. got7fsn_ti heart vascular smooth muscle cell differentiation dph 2009-09-29T02:56:08Z biological_process owl:Class
GO:0102767 biolink:NamedThing flavanone 4'-O-methyltransferase activity Catalysis of the reaction: (S)-naringenin + S-adenosyl-L-methionine = 2 H+ + ponciretin + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.231|MetaCyc:RXN-7777|RHEA:31743 molecular_function owl:Class
GO:0071985 biolink:NamedThing multivesicular body sorting pathway A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded. got7fsn_ti mah 2010-10-22T12:04:16Z biological_process owl:Class
GO:0015549 biolink:NamedThing carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity Enables the transfer of carbonyl cyanide m-chlorophenylhydrazone from one side of a membrane to the other. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. got7fsn_ti carbonyl cyanide m-chlorophenylhydrazone transporter activity|CCCP transporter activity|carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity molecular_function owl:Class
GO:0034789 biolink:NamedThing 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + phthalate + H+. got7fsn_ti UM-BBD_reactionID:r1042 molecular_function owl:Class
GO:0061706 biolink:NamedThing glycolytic process from sucrose through glucose and fructose The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. got7fsn_ti dph 2015-06-11T13:40:32Z MetaCyc:PWY-1042 biological_process owl:Class
GO:0061704 biolink:NamedThing glycolytic process from sucrose The chemical reactions and pathways resulting in the breakdown of a sucrose into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. got7fsn_ti dph 2015-06-11T13:26:28Z biological_process owl:Class
GO:0005178 biolink:NamedThing integrin binding Binding to an integrin. got7fsn_ti integrin ligand molecular_function owl:Class
GO:0009867 biolink:NamedThing jasmonic acid mediated signaling pathway A series of molecular signals mediated by jasmonic acid. got7fsn_ti JA signaling|jasmonate signaling|jasmonic acid mediated signalling pathway biological_process owl:Class
GO:0097023 biolink:NamedThing fructose 6-phosphate aldolase activity Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate. got7fsn_ti pr 2011-03-29T04:54:05Z RHEA:28002 molecular_function owl:Class
GO:0039699 biolink:NamedThing viral mRNA cap methylation Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a viral mRNA. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs. got7fsn_ti IFIT mRNA restriction evasion by virus bf 2013-11-06T14:39:17Z biological_process owl:Class
GO:0046793 biolink:NamedThing induction by virus of phosphorylation of host RNA polymerase II Any process in which a virus activates the frequency, rate or extent of phosphorylation of host RNA polymerase II. got7fsn_ti virus-induced modification of host RNA polymerase II|induction by virus of modification of host RNA polymerase II biological_process owl:Class
GO:0019056 biolink:NamedThing modulation by virus of host transcription Any process in which a virus modulates the frequency, rate or extent of its host's transcription. got7fsn_ti modification by virus of host transcription|viral perturbation of host cell transcription biological_process owl:Class
GO:0061800 biolink:NamedThing fibronectin fibril A supramolecular fiber formed from fibronectin molecules. The fibrils are 5 to 25nm in diameter and can form branched meshworks. got7fsn_ti dph 2016-10-24T14:04:21Z cellular_component owl:Class
GO:0039604 biolink:NamedThing suppression by virus of host translation Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA. got7fsn_ti host translation shutoff by virus|viral inhibition of cellular protein synthesis|viral shutoff of host protein synthesis bf 2012-07-05T04:25:22Z VZ:1579 biological_process owl:Class
GO:0039657 biolink:NamedThing suppression by virus of host gene expression Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. got7fsn_ti host gene expression shutoff by virus bf 2013-06-20T15:29:55Z VZ:1582 biological_process owl:Class
GO:0047306 biolink:NamedThing D-methionine-pyruvate transaminase activity Catalysis of the reaction: D-methionine + pyruvate = 4-methylthio-2-oxobutanoate + L-alanine. got7fsn_ti D-methionine:pyruvate aminotransferase activity|D-methionine aminotransferase activity|D-methionine--pyruvate aminotransferase activity|D-methionine-pyruvate aminotransferase activity|D-methionine transaminase activity RHEA:23836|KEGG_REACTION:R03001|MetaCyc:2.6.1.41-RXN|EC:2.6.1.41 molecular_function owl:Class
GO:0019782 biolink:NamedThing ISG15 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti UBE1L molecular_function owl:Class
GO:0097594 biolink:NamedThing ventral disc dorsal microribbon Trilaminar structure extending perpendicularly into the cytoplasm along the length of ventral disc microtubules in Giardia species (trophozoite stage). Constituents of dorsal microribbons (also called dorsal ribbons or microribbons) include alpha-coiled-helix proteins approximately 29 to 38 kDa in size. These proteins line the edges of the microribbons but are not found in microtubules. Tubulins are not found in microribbons. got7fsn_ti ventral disk dorsal microribbon|dorsal ribbon|microribbon|dorsal microribbon Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-04-03T11:20:06Z cellular_component owl:Class
GO:0004132 biolink:NamedThing dCMP deaminase activity Catalysis of the reaction: dCMP + H2O = dUMP + NH3. got7fsn_ti deoxycytidine-5'-monophosphate aminohydrolase activity|deoxycytidine-5'-phosphate deaminase activity|deoxycytidine monophosphate deaminase activity|dCMP aminohydrolase activity|deoxycytidylate deaminase activity|deoxycytidylate aminohydrolase activity|deoxy-CMP-deaminase activity RHEA:22924|EC:3.5.4.12|MetaCyc:DCMP-DEAMINASE-RXN|Reactome:R-HSA-73596 molecular_function owl:Class
GO:0019083 biolink:NamedThing viral transcription The process by which a viral genome, or part of a viral genome, is transcribed within the host cell. got7fsn_ti biological_process owl:Class
GO:1990136 biolink:NamedThing linoleate 9S-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate. got7fsn_ti linoleate 9-lipoxygenase activity|9-lipoxygenase activity|linoleate:oxygen 9S-oxidoreductase activity|9S-lipoxygenase activity pr 2013-07-03T12:20:57Z EC:1.13.11.58|RHEA:30291 molecular_function owl:Class
GO:0010467 biolink:NamedThing gene expression The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. got7fsn_ti Wikipedia:Gene_expression biological_process owl:Class
GO:0036471 biolink:NamedThing cellular response to glyoxal Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus. got7fsn_ti bf 2014-07-21T11:14:33Z biological_process owl:Class
GO:0047828 biolink:NamedThing D-lyxose ketol-isomerase activity Catalysis of the reaction: D-lyxose = D-xylulose. got7fsn_ti D-lyxose isomerase activity|D-lyxose aldose-ketose-isomerase activity RHEA:14201|EC:5.3.1.15|KEGG_REACTION:R01898|MetaCyc:D-LYXOSE-KETOL-ISOMERASE-RXN molecular_function owl:Class
GO:0050976 biolink:NamedThing detection of mechanical stimulus involved in sensory perception of touch The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal. got7fsn_ti perception of touch, sensory transduction of mechanical stimulus|tactition, sensory detection of mechanical stimulus|perception of touch, sensory detection of mechanical stimulus|sensory detection of mechanical stimulus during perception of touch|perception of touch, detection of mechanical stimulus|sensory transduction of mechanical stimulus during perception of touch biological_process owl:Class
GO:0050974 biolink:NamedThing detection of mechanical stimulus involved in sensory perception The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception. got7fsn_ti sensory perception, sensory transduction of mechanical stimulus|sensory perception, sensory detection of mechanical stimulus|sensory transduction of mechanical stimulus during sensory perception|sensory detection of mechanical stimulus during sensory perception|sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus biological_process owl:Class
GO:0061025 biolink:NamedThing membrane fusion The membrane organization process that joins two lipid bilayers to form a single membrane. got7fsn_ti cellular membrane fusion|single-organism membrane fusion jl 2010-02-08T02:48:06Z GO:0006944|GO:0044801 Wikipedia:Lipid_bilayer_fusion biological_process owl:Class
GO:0033912 biolink:NamedThing 2,6-beta-fructan 6-levanbiohydrolase activity Catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain. got7fsn_ti 2,6-beta-D-fructan 6-levanbiohydrolase activity|2,6-beta-D-fructofuranan 6-(beta-D-fructosyl)-D-fructose-hydrolase activity|2,6-beta-D-fructan 6-beta-D-fructofuranosylfructohydrolase activity|beta-2,6-fructan-6-levanbiohydrolase activity|levanbiose-producing levanase activity EC:3.2.1.64|MetaCyc:3.2.1.64-RXN molecular_function owl:Class
GO:0102136 biolink:NamedThing 3-epi-6-deoxocathasterone C-23 hydroxylase activity Catalysis of the reaction: H+ + 3-epi-6-deoxocathasterone + reduced (NADPH-hemoprotein reducdtase) + O2 = 6=deoxotyphasterol + oxidized (NADPH-hemoprotein reductase) + H2O. got7fsn_ti EC:1.14.14.147|MetaCyc:RXN-11531|RHEA:27321 molecular_function owl:Class
GO:0050457 biolink:NamedThing decylcitrate synthase activity Catalysis of the reaction: H(2)O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+). got7fsn_ti (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA-acylating)|2-decylcitrate synthase activity|(2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate oxaloacetate-lyase (CoA- acylating) activity|dodecanoyl-CoA:oxaloacetate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming) MetaCyc:DECYLCITRATE-SYNTHASE-RXN|RHEA:16605|KEGG_REACTION:R03735|EC:2.3.3.2 molecular_function owl:Class
GO:0050793 biolink:NamedThing regulation of developmental process Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). got7fsn_ti biological_process owl:Class
GO:0035095 biolink:NamedThing behavioral response to nicotine Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus. got7fsn_ti behavioural response to nicotine biological_process owl:Class
GO:0030534 biolink:NamedThing adult behavior Behavior in a fully developed and mature organism. got7fsn_ti adult behavioural response to stimulus|adult behavioral response to stimulus|adult behaviour See also the biological process term 'behavior ; GO:0007610'. biological_process owl:Class
GO:0072682 biolink:NamedThing eosinophil extravasation The migration of an eosinophil from the blood vessels into the surrounding tissue. got7fsn_ti mah 2011-02-22T04:02:22Z biological_process owl:Class
GO:0072677 biolink:NamedThing eosinophil migration The movement of an eosinophil within or between different tissues and organs of the body. got7fsn_ti mah 2011-02-22T03:39:31Z biological_process owl:Class
GO:0035936 biolink:NamedThing testosterone secretion The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5. got7fsn_ti bf 2011-07-20T01:13:13Z biological_process owl:Class
GO:0046879 biolink:NamedThing hormone secretion The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. got7fsn_ti biological_process owl:Class
GO:1990326 biolink:NamedThing collagen type XXVIII trimer A collagen homotrimer of alpha1(XXVIII) chains. got7fsn_ti bhm 2014-03-16T23:15:28Z cellular_component owl:Class
GO:0033678 biolink:NamedThing 5'-3' DNA/RNA helicase activity Unwinding of a DNA/RNA duplex in the 5' to 3' direction, driven by ATP hydrolysis. got7fsn_ti ATP-dependent 5'-3' DNA/RNA helicase activity|ATP-dependent 5' to 3' DNA/RNA helicase activity|5' to 3' DNA/RNA helicase activity https://github.com/geneontology/go-ontology/issues/21612 GO:0033682 Reactome:R-HSA-163120 molecular_function owl:Class
GO:0033677 biolink:NamedThing DNA/RNA helicase activity Unwinding of a DNA/RNA duplex, i.e. a double helix in which a strand of DNA pairs with a complementary strand of RNA, driven by ATP hydrolysis. got7fsn_ti ATP-dependent DNA/RNA helicase activity https://github.com/geneontology/go-ontology/issues/21612 GO:0033680 molecular_function owl:Class
GO:0018801 biolink:NamedThing glutaconyl-CoA decarboxylase activity Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2). got7fsn_ti 4-carboxybut-2-enoyl-CoA carboxy-lyase activity|glutaconyl coenzyme A decarboxylase activity|4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)|pent-2-enoyl-CoA carboxy-lyase activity EC:7.2.4.5|KEGG_REACTION:R03028|RHEA:23972|MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN|UM-BBD_reactionID:r0199 molecular_function owl:Class
GO:0002568 biolink:NamedThing somatic diversification of T cell receptor genes The somatic process that results in the generation of sequence diversity of T cell receptor genes. got7fsn_ti somatic diversification of TCR genes biological_process owl:Class
GO:0033984 biolink:NamedThing indole-3-glycerol-phosphate lyase activity Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate. got7fsn_ti indole synthase activity|indole-3-glycerol phosphate lyase activity|BX1|tryptophan synthase alpha subunit activity|indole glycerol phosphate hydrolase activity|(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming) activity|TSA|tryptophan synthase alpha activity|(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate D-glyceraldehyde-3-phosphate-lyase activity|indoleglycerolphosphate aldolase activity|indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity|IGL KEGG_REACTION:R02340|MetaCyc:4.1.2.8-RXN|MetaCyc:RXN0-2381|EC:4.1.2.8|RHEA:14081 molecular_function owl:Class
GO:0000142 biolink:NamedThing cellular bud neck contractile ring A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae. got7fsn_ti neck ring cellular_component owl:Class
GO:0110085 biolink:NamedThing mitotic actomyosin contractile ring A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis. got7fsn_ti kmv 2018-02-12T17:04:02Z cellular_component owl:Class
GO:0005802 biolink:NamedThing trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. got7fsn_ti late Golgi|maturing face|TGN|trans Golgi network|trans face|Golgi trans face|Golgi trans-face There are different opinions about whether the TGN should be considered part of the Golgi apparatus or not. We follow Alberts et al, 1994 (ISBN:0815316194), who consider it to be a part. NIF_Subcellular:sao9456487 cellular_component owl:Class
GO:1990432 biolink:NamedThing siRNA 3'-end processing The process of forming the mature 3' end of a siRNA molecule. got7fsn_ti siRNA 3' end processing|small interfering RNA 3'-end processing jl 2014-07-29T15:38:38Z biological_process owl:Class
GO:0102541 biolink:NamedThing D-galactose 6-phosphate 1-epimerase activity Catalysis of the reaction: alpha-D-galactose 6-phosphate = beta-D-galactose 6-phosphate. got7fsn_ti MetaCyc:RXN-14816 molecular_function owl:Class
GO:0008421 biolink:NamedThing long-chain fatty-acyl-glutamate deacylase activity Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate. got7fsn_ti N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity|long-chain acylglutamate amidase activity|long-chain-fatty-acyl-glutamate deacylase activity|long-chain fatty acyl-glutamate deacylase activity|long-chain aminoacylase activity MetaCyc:3.5.1.55-RXN|EC:3.5.1.55|RHEA:17517 molecular_function owl:Class
GO:0097114 biolink:NamedThing NMDA glutamate receptor clustering The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane. got7fsn_ti NMDA receptor clustering|N-methyl-D-aspartate receptor clustering pr 2011-07-31T05:30:15Z biological_process owl:Class
GO:0033765 biolink:NamedThing steroid dehydrogenase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor, and in which one substrate is a sterol derivative. got7fsn_ti molecular_function owl:Class
GO:0016229 biolink:NamedThing steroid dehydrogenase activity Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. got7fsn_ti molecular_function owl:Class
GO:0048925 biolink:NamedThing lateral line system development The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear. got7fsn_ti biological_process owl:Class
GO:0048880 biolink:NamedThing sensory system development The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0098022 biolink:NamedThing viral capsid, fiber A type of capsid decoration composed of fiber structures. got7fsn_ti head/capsid fiber bm 2012-07-19T11:56:32Z cellular_component owl:Class
GO:0098021 biolink:NamedThing viral capsid, decoration Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential. got7fsn_ti decoration protein bm 2012-07-19T11:52:53Z cellular_component owl:Class
GO:0051721 biolink:NamedThing protein phosphatase 2A binding Binding to protein phosphatase 2A. got7fsn_ti protein phosphatase 2 binding molecular_function owl:Class
GO:0019903 biolink:NamedThing protein phosphatase binding Binding to a protein phosphatase. got7fsn_ti molecular_function owl:Class
GO:0004045 biolink:NamedThing aminoacyl-tRNA hydrolase activity Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. got7fsn_ti N-substituted aminoacyl transfer RNA hydrolase activity|aminoacyl-tRNA hydrolase reaction|peptidyl-tRNA hydrolase activity|aminoacyl-transfer ribonucleate hydrolase activity|D-tyrosyl-tRNA hydrolase activity|aminoacyl-tRNA aminoacylhydrolase activity GO:0019851|GO:0019850 MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN|EC:3.1.1.29|RHEA:54448 molecular_function owl:Class
GO:0030298 biolink:NamedThing receptor signaling protein tyrosine kinase activator activity Binds to and increases the activity of a receptor signaling protein tyrosine kinase. got7fsn_ti receptor signalling protein tyrosine kinase activator activity molecular_function owl:Class
GO:0030296 biolink:NamedThing protein tyrosine kinase activator activity Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. got7fsn_ti molecular_function owl:Class
GO:0032151 biolink:NamedThing mitotic septin complex A heterooligomeric septin complex that acts during mitotic cell division. got7fsn_ti cellular_component owl:Class
GO:0031105 biolink:NamedThing septin complex A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric. got7fsn_ti cellular_component owl:Class
GO:0038190 biolink:NamedThing VEGF-activated neuropilin signaling pathway A series of molecular signals initiated by the binding of vascular endothelial growth factor (VEGF) to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti vascular endothelial growth factor-activated neuropilin signaling pathway|VEGF-Npn-1 signaling bf 2013-08-01T16:06:49Z biological_process owl:Class
GO:0038084 biolink:NamedThing vascular endothelial growth factor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGF-activated signaling pathway|vascular endothelial growth factor signalling pathway|VEGF signaling In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0038084 is for annotation of any pathway in which the ligand VEGF binds and activates any cell surface receptor (VEGFR, PDGFR etc.). For annotation of signaling pathways where a VEGFR binds one of its physiological ligands (VEGF or an alternative growth factor), consider 'vascular endothelial growth factor receptor signaling pathway ; GO:0048010'. bf 2012-02-01T02:27:32Z biological_process owl:Class
GO:0060233 biolink:NamedThing oenocyte delamination The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet. got7fsn_ti biological_process owl:Class
GO:0060232 biolink:NamedThing delamination The process of negative regulation of cell adhesion that results in a cell or sheet of cells splitting off from an existing epithelial sheet. got7fsn_ti biological_process owl:Class
GO:0061034 biolink:NamedThing olfactory bulb mitral cell layer development The progression of the olfactory bulb mitral cell layer over time from its initial formation until its mature state. The mitral cell layer is composed of pyramidal neurons whose cell bodies are located between the granule cell layer and the plexiform layer. got7fsn_ti dph 2010-02-09T03:30:23Z biological_process owl:Class
GO:0018858 biolink:NamedThing benzoate-CoA ligase activity Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate. got7fsn_ti benzoate-coenzyme A ligase activity|benzoate:CoA ligase (AMP-forming)|benzoyl CoA synthetase (AMP forming)|benzoyl-coenzyme A synthetase activity KEGG_REACTION:R01422|MetaCyc:BENZOATE--COA-LIGASE-RXN|RHEA:10132|EC:6.2.1.25|UM-BBD_reactionID:r0189 molecular_function owl:Class
GO:0034630 biolink:NamedThing RITS complex localization Any process in which a RITS complex is transported to, or maintained in, a specific location. got7fsn_ti RITS complex localisation|establishment and maintenance of RITS complex localization biological_process owl:Class
GO:0043715 biolink:NamedThing 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P. got7fsn_ti mtnW|DK-MTP-1-P enolase activity|MasA|E-1 This function is part of the process of methionine salvage. EC:5.3.2.5|MetaCyc:R82-RXN|RHEA:18769 molecular_function owl:Class
GO:0002458 biolink:NamedThing peripheral T cell tolerance induction Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus. got7fsn_ti peripheral T-lymphocyte tolerance induction|peripheral T-cell tolerance induction|peripheral T lymphocyte tolerance induction biological_process owl:Class
GO:0002517 biolink:NamedThing T cell tolerance induction A process involving any mechanism for tolerance induction in T cells. got7fsn_ti T-lymphocyte tolerance induction|T-cell tolerance induction|T lymphocyte tolerance induction biological_process owl:Class
GO:0033093 biolink:NamedThing Weibel-Palade body A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. got7fsn_ti Wikipedia:Weibel-Palade_body cellular_component owl:Class
GO:0030136 biolink:NamedThing clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. got7fsn_ti NIF_Subcellular:sao148845161 cellular_component owl:Class
GO:0102674 biolink:NamedThing C4-demethylase activity Catalysis of the reaction: 24-methylenelophenol + a demethylated methyl acceptor <=> 9xi-episterol + a methylated methyl acceptor. got7fsn_ti MetaCyc:RXN-4181 molecular_function owl:Class
GO:0022839 biolink:NamedThing ion gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. got7fsn_ti molecular_function owl:Class
GO:0061205 biolink:NamedThing paramesonephric duct development The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin. got7fsn_ti Mullerian duct development dph 2010-07-30T10:54:47Z biological_process owl:Class
GO:0016501 biolink:NamedThing prostacyclin receptor activity Combining with prostacyclin (PGI(2)) to initiate a change in cell activity. got7fsn_ti PGI receptor activity|PGI(2) receptor activity|prostaglandin I receptor activity GO:0004959 molecular_function owl:Class
GO:0001826 biolink:NamedThing inner cell mass cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell. got7fsn_ti See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. biological_process owl:Class
GO:0033567 biolink:NamedThing DNA replication, Okazaki fragment processing The DNA metabolic process, occurring during lagging strand synthesis, by which RNA primers are removed from Okazaki fragments, the resulting gaps filled by DNA polymerization, and the ends ligated to form a continuous strand. got7fsn_ti biological_process owl:Class
GO:0071572 biolink:NamedThing histone H3-K56 deacetylation The modification of histone H3 by the removal of an acetyl group from lysine at position 56 of the histone. got7fsn_ti mah 2010-01-20T04:50:03Z biological_process owl:Class
GO:0070932 biolink:NamedThing histone H3 deacetylation The modification of histone H3 by the removal of one or more acetyl groups. got7fsn_ti mah 2009-09-16T04:50:55Z biological_process owl:Class
GO:0018355 biolink:NamedThing protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine. got7fsn_ti biological_process owl:Class
GO:0018247 biolink:NamedThing protein-phosphoribosyl dephospho-coenzyme A linkage The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position. got7fsn_ti RESID:AA0167 biological_process owl:Class
GO:0017125 biolink:NamedThing deoxycytidyl transferase activity Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA. got7fsn_ti deoxycytidyl transferase activity, template-dependent GO:0019986 Reactome:R-HSA-110308 molecular_function owl:Class
GO:0035991 biolink:NamedThing nitric oxide sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO). got7fsn_ti NO sensor activity bf 2011-08-26T04:32:16Z molecular_function owl:Class
GO:0070026 biolink:NamedThing nitric oxide binding Binding to nitric oxide (NO). got7fsn_ti NO binding|nitrosyl binding|nitrogen monoxide binding molecular_function owl:Class
GO:0019577 biolink:NamedThing aldaric acid metabolic process The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. got7fsn_ti aldaric acid metabolism biological_process owl:Class
GO:0005975 biolink:NamedThing carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. got7fsn_ti multicellular organismal carbohydrate metabolic process|single-organism carbohydrate metabolic process|carbohydrate metabolism jl 2012-10-23T15:40:34Z GO:0044723|GO:0044261 Wikipedia:Carbohydrate_metabolism biological_process owl:Class
GO:1990762 biolink:NamedThing cytoplasmic alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation. got7fsn_ti vw 2015-06-08T15:56:51Z biological_process owl:Class
GO:0006419 biolink:NamedThing alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA. got7fsn_ti biological_process owl:Class
GO:0072256 biolink:NamedThing metanephric glomerular mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular mesangial cell. got7fsn_ti mah 2010-03-19T04:07:10Z biological_process owl:Class
GO:0072152 biolink:NamedThing glomerular mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular mesangial cell. got7fsn_ti mah 2010-02-24T02:14:58Z biological_process owl:Class
GO:0010333 biolink:NamedThing terpene synthase activity Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units. got7fsn_ti molecular_function owl:Class
GO:0042960 biolink:NamedThing antimonite secondary active transmembrane transporter activity Enables the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti antimonite porter activity molecular_function owl:Class
GO:0061630 biolink:NamedThing ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. got7fsn_ti ubiquitin ligase activity involved in ER-associated degradation pathway|E3 involved in endoplasmic reticulum-associated degradation|ubiquitin protein ligase activity involved in ER-associated degradation pathway|ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition|ubiquitin protein ligase activity involved in ERAD pathway|ubiquitin protein ligase activity involved in chloroplast disassembly|ER-associated E3 ligase|APC-Cdc20 complex activity|APC-fizzy related complex activity|ubiquitin ligase activity|protein ubiquitination activity|E3 This enzyme catalyzes a transferase reaction. dph 2014-05-18T09:11:21Z GO:0090302|GO:1904822|GO:0090622|GO:1904264 Reactome:R-HSA-8854051|Reactome:R-HSA-9009308|Reactome:R-HSA-4608852|Reactome:R-HSA-8942101|Reactome:R-HSA-5674022|Reactome:R-HSA-5690827|Reactome:R-HSA-5632648|Reactome:R-HSA-1504190|Reactome:R-HSA-5682858|Reactome:R-HSA-8943040|Reactome:R-HSA-6804879|Reactome:R-HSA-8956684|Reactome:R-HSA-8943003|Reactome:R-HSA-8953946|Reactome:R-HSA-201445|Reactome:R-HSA-3640861|Reactome:R-HSA-9686969|Reactome:R-HSA-5610737|Reactome:R-HSA-6804724|Reactome:R-HSA-8948775|Reactome:R-HSA-68946|Reactome:R-HSA-8943080|Reactome:R-HSA-4641159|Reactome:R-HSA-5654677|Reactome:R-HSA-6804441|Reactome:R-HSA-8851011|Reactome:R-HSA-9604629|Reactome:R-HSA-6804253|Reactome:R-HSA-6782943|Reactome:R-HSA-9008479|Reactome:R-HSA-5654684|Reactome:R-HSA-8939706|Reactome:R-HSA-6807134|Reactome:R-HSA-3322429|Reactome:R-HSA-8875431|Reactome:R-HSA-8875183|Reactome:R-HSA-6798373|Reactome:R-HSA-9011300|Reactome:R-HSA-8848829|Reactome:R-HSA-6781867|Reactome:R-HSA-9021523|Reactome:R-HSA-8938773|Reactome:R-HSA-8952382|Reactome:R-HSA-8956026|Reactome:R-HSA-9706354|Reactome:R-HSA-936462|Reactome:R-HSA-9686920|Reactome:R-HSA-8866546|Reactome:R-HSA-8867288|Reactome:R-HSA-4641129|Reactome:R-HSA-6785361|Reactome:R-HSA-8877003|Reactome:R-HSA-8938815|Reactome:R-HSA-6807106|Reactome:R-HSA-5687081|Reactome:R-HSA-4641253|Reactome:R-HSA-990526|Reactome:R-HSA-5635856|Reactome:R-HSA-9008076|Reactome:R-HSA-5654679|Reactome:R-HSA-5635864|Reactome:R-HSA-8866856|Reactome:R-HSA-6790487|Reactome:R-HSA-5246693|Reactome:R-HSA-69015|Reactome:R-HSA-8948832|Reactome:R-HSA-5689111|Reactome:R-HSA-5658424|Reactome:R-HSA-4641246|Reactome:R-HSA-8939335|Reactome:R-HSA-5684071|Reactome:R-HSA-5654672|Reactome:R-HSA-934604|Reactome:R-HSA-8952419|Reactome:R-HSA-8876258|Reactome:R-HSA-936475|Reactome:R-HSA-8854628|Reactome:R-HSA-8854041|Reactome:R-HSA-6804942|Reactome:R-HSA-9706356|Reactome:R-HSA-1225956|Reactome:R-HSA-9009403|Reactome:R-HSA-9033485 molecular_function owl:Class
GO:0004842 biolink:NamedThing ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. got7fsn_ti E2|ubiquitin conjugating enzyme activity|ubiquitin protein ligase activity|E3|ubiquitin protein-ligase activity|ubiquitin ligase activity|ubiquitin-conjugating enzyme activity|anaphase-promoting complex activity GO:0004840|GO:0004841 Reactome:R-HSA-1253282|Reactome:R-HSA-5660753|Reactome:R-HSA-1234172|Reactome:R-HSA-2730904|Reactome:R-HSA-5610745|Reactome:R-HSA-3797226|Reactome:R-HSA-1852623|Reactome:R-HSA-9013069|Reactome:R-HSA-1912386|Reactome:R-HSA-5610746|Reactome:R-HSA-180540|Reactome:R-HSA-211734|Reactome:R-HSA-1234163|Reactome:R-HSA-9688831|Reactome:R-HSA-3781009|Reactome:R-HSA-2172172|Reactome:R-HSA-1358789|Reactome:R-HSA-8956106|Reactome:R-HSA-5693108|Reactome:R-HSA-182993|Reactome:R-HSA-183051|Reactome:R-HSA-2187368|Reactome:R-HSA-187575|Reactome:R-HSA-5362412|Reactome:R-HSA-168915|Reactome:R-HSA-2900765|Reactome:R-HSA-3134946|Reactome:R-HSA-741386|Reactome:R-HSA-174057|Reactome:R-HSA-983140|KEGG_REACTION:R03876|Reactome:R-HSA-2737728|Reactome:R-HSA-5655170|Reactome:R-HSA-1169402|Reactome:R-HSA-205118|Reactome:R-HSA-183036|Reactome:R-HSA-936942|Reactome:R-HSA-2169050|Reactome:R-HSA-201425|Reactome:R-HSA-3000335|Reactome:R-HSA-3249386|Reactome:R-HSA-5607756|Reactome:R-HSA-9645414|Reactome:R-HSA-180597|Reactome:R-HSA-936412|Reactome:R-HSA-1358792|Reactome:R-HSA-174227|Reactome:R-HSA-450358|Reactome:R-HSA-5607728|Reactome:R-HSA-5667111|Reactome:R-HSA-1169394|Reactome:R-HSA-5357757|Reactome:R-HSA-5652009|Reactome:R-HSA-183084|Reactome:R-HSA-69598|Reactome:R-HSA-1169398|Reactome:R-HSA-1977296|Reactome:R-HSA-983156|Reactome:R-HSA-75824|Reactome:R-HSA-5610742|Reactome:R-HSA-3780995|Reactome:R-HSA-173545|Reactome:R-HSA-2179276|Reactome:R-HSA-1169397|Reactome:R-HSA-3134804|Reactome:R-HSA-174195|Reactome:R-HSA-1980118|Reactome:R-HSA-9645394|Reactome:R-HSA-446877|Reactome:R-HSA-4332236|Reactome:R-HSA-1918092|Reactome:R-HSA-5483238|Reactome:R-HSA-9628444|Reactome:R-HSA-1363331|Reactome:R-HSA-9013974|Reactome:R-HSA-2682349|Reactome:R-HSA-183089|Reactome:R-HSA-870449|Reactome:R-HSA-202453|Reactome:R-HSA-2213017|Reactome:R-HSA-1169405|Reactome:R-HSA-9701000|Reactome:R-HSA-5691108|Reactome:R-HSA-209063|Reactome:R-HSA-5668534|Reactome:R-HSA-179417|Reactome:R-HSA-5667107|Reactome:R-HSA-918224|Reactome:R-HSA-5675470|Reactome:R-HSA-2769007|Reactome:R-HSA-5205682|Reactome:R-HSA-5607725|Reactome:R-HSA-5607757|Reactome:R-HSA-975118|Reactome:R-HSA-400267|Reactome:R-HSA-1169406|Reactome:R-HSA-1169395|Reactome:R-HSA-1980074|Reactome:R-HSA-182986|Reactome:R-HSA-174144|Reactome:R-HSA-264444|Reactome:R-HSA-3788724|Reactome:R-HSA-5668454|Reactome:R-HSA-2186747|Reactome:R-HSA-5684250|Reactome:R-HSA-975147|Reactome:R-HSA-451418|Reactome:R-HSA-1912357|Reactome:R-HSA-174104|Reactome:R-HSA-1918095|Reactome:R-HSA-8948709|Reactome:R-HSA-173542|Reactome:R-HSA-983153|Reactome:R-HSA-202534|Reactome:R-HSA-9014342|Reactome:R-HSA-174159|Reactome:R-HSA-1358790|Reactome:R-HSA-2186785|Reactome:R-HSA-936986 molecular_function owl:Class
GO:0017067 biolink:NamedThing tyrosine-ester sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+). got7fsn_ti aryl sulfotransferase IV|tyrosine-ester sulphotransferase activity|L-tyrosine methyl ester sulfotransferase activity|3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity GO:0008128 KEGG_REACTION:R04213|MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN|EC:2.8.2.9|RHEA:19977 molecular_function owl:Class
GO:0048796 biolink:NamedThing swim bladder maturation A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. got7fsn_ti gas bladder maturation biological_process owl:Class
GO:0102327 biolink:NamedThing 3-oxoacyl-CoA hydrolase activity Catalysis of the reaction: H2O + a 3-oxoacyl-CoA = H+ + coenzyme A + a 3-oxoacid. got7fsn_ti MetaCyc:RXN-13247 molecular_function owl:Class
GO:0016790 biolink:NamedThing thiolester hydrolase activity Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. got7fsn_ti thiolesterase activity EC:3.1.2.- molecular_function owl:Class
GO:2000871 biolink:NamedThing negative regulation of progesterone secretion Any process that stops, prevents or reduces the frequency, rate or extent of progesterone secretion. got7fsn_ti bf 2011-07-26T08:51:19Z biological_process owl:Class
GO:2000832 biolink:NamedThing negative regulation of steroid hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion. got7fsn_ti bf 2011-07-26T08:38:50Z biological_process owl:Class
GO:0071625 biolink:NamedThing vocalization behavior The behavior in which an organism produces sounds by a mechanism involving its respiratory system. got7fsn_ti vocalisation behaviour mah 2010-02-10T11:02:58Z biological_process owl:Class
GO:0007610 biolink:NamedThing behavior The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. got7fsn_ti behavioral response to stimulus|behaviour|single-organism behavior|behavioural response to stimulus 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews. 2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). jl 2012-09-20T14:06:08Z GO:0023032|GO:0044709|GO:0044708 Wikipedia:Behavior biological_process owl:Class
GO:0005158 biolink:NamedThing insulin receptor binding Binding to an insulin receptor. got7fsn_ti insulin receptor ligand molecular_function owl:Class
GO:0002509 biolink:NamedThing central tolerance induction to self antigen Tolerance induction in the central lymphoid organs directed at self antigens. got7fsn_ti biological_process owl:Class
GO:0048581 biolink:NamedThing negative regulation of post-embryonic development Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. got7fsn_ti inhibition of post-embryonic development|down regulation of post-embryonic development|downregulation of post-embryonic development|down-regulation of post-embryonic development biological_process owl:Class
GO:0140567 biolink:NamedThing transmembrane protein dislocase activity The activity of removing a protein from a membrane, by binding to a transmembrane helical fragment of a tail-anchored protein and releasing it from the the hydrophobic region of one or both lipid bilayers. got7fsn_ti transmembrane helix dislocase https://github.com/geneontology/go-ontology/issues/20237 pg 2020-12-15T07:13:21Z RHEA:66168 molecular_function owl:Class
GO:0140318 biolink:NamedThing protein transporter activity Directly binding to a specific protein and delivering it to a specific cellular location. got7fsn_ti protein transport chaperone|protein carrier activity https://github.com/geneontology/go-ontology/issues/17073 Examples of protein carriers include the soluble TIM chaperone complexes of S. cerevisiae Tim9-Tim10 and Tim8-Tim13, that provide a shuttle system between TOM and the membrane insertases TIM22 and SAM and, thus, ensure that precursors are kept in a translocation-competent conformation. pg 2019-04-01T10:41:38Z Reactome:R-HSA-9662747|Reactome:R-HSA-9662818 molecular_function owl:Class
GO:0004338 biolink:NamedThing glucan exo-1,3-beta-glucosidase activity Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose. got7fsn_ti exo-1,3-beta-D-glucanase activity|1,3-beta-glucan glucohydrolase activity|exo-beta-(1->3)-glucanohydrolase activity|exo (1->3)-beta-glucanase activity|exo-1,3-beta-glucanase activity|exo-1,3-beta-glucosidase activity|exo-beta-1,3-glucanase activity|exo-beta-1,3-D-glucanase activity|beta-1,3-glucan exo-hydrolase activity|glucan 1,3-beta-glucosidase activity|exo-beta-(1->3)-D-glucanase activity EC:3.2.1.58|MetaCyc:3.2.1.58-RXN molecular_function owl:Class
GO:0034150 biolink:NamedThing toll-like receptor 6 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 6. got7fsn_ti toll-like receptor 6 signalling pathway|TLR6 signaling pathway biological_process owl:Class
GO:0002224 biolink:NamedThing toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. got7fsn_ti toll-like receptor signalling pathway|TLR signaling pathway Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. biological_process owl:Class
GO:0045201 biolink:NamedThing maintenance of neuroblast polarity The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. got7fsn_ti maintenance of neuroblast cell polarity GO:0043341|GO:0043344 biological_process owl:Class
GO:0075192 biolink:NamedThing haustorium mother cell formation The process in which a symbiont cell is formed, separated from the tip of an infection hypha by a septum. The haustorium mother cell usually contains 2-4 fungal nuclei, and its function is to attach and penetrate the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti haustorium mother cell formation on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0075015 biolink:NamedThing formation of infection structure The formation of a symbiont structure that serves to infect its host organism. It includes physiological, developmental, and morphological changes of the symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti formation by symbiont of infection structure on or near host|formation of host infection structure|formation of host penetration structure|formation of infection structure on or near host https://github.com/geneontology/go-ontology/issues/20472|https://github.com/geneontology/go-ontology/issues/19014 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. biological_process owl:Class
GO:0102606 biolink:NamedThing octat-9-en-7-ol 5-monooxygenase activity Catalysis of the reaction: cyclooctat-9-en-7-ol + O2 + NADPH + H+ <=> cyclooctat-9-en-5,7-diol + H2O + NADP. got7fsn_ti MetaCyc:RXN-15431|RHEA:56820 molecular_function owl:Class
GO:0004782 biolink:NamedThing sulfinoalanine decarboxylase activity Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2. got7fsn_ti L-cysteinesulfinic acid decarboxylase activity|sulphinoalanine decarboxylase activity|CSADCase activity|cysteine-sulfinate decarboxylase activity|sulfoalanine decarboxylase activity|CADCase/CSADCase activity|cysteinesulfinic acid decarboxylase activity|cysteic decarboxylase activity|3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)|cysteinesulfinate decarboxylase activity|CSAD|3-sulfino-L-alanine carboxy-lyase activity RHEA:16877|Reactome:R-HSA-1655443|EC:4.1.1.29|MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN molecular_function owl:Class
GO:0035194 biolink:NamedThing post-transcriptional gene silencing by RNA Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger RNA (often mRNA) degradation or negatively regulate mRNA translation. got7fsn_ti sense-PTGS|RNA-mediated posttranscriptional gene silencing|posttranscriptional gene silencing by RNA biological_process owl:Class
GO:0016441 biolink:NamedThing posttranscriptional gene silencing The inactivation of gene expression by a posttranscriptional mechanism. got7fsn_ti quelling|PTGS|post-transcriptional gene silencing|cosuppression Wikipedia:Post_transcriptional_gene_silencing biological_process owl:Class
GO:0045486 biolink:NamedThing naringenin 3-dioxygenase activity Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2. got7fsn_ti flavanone 3-dioxygenase activity|flavanone 3-beta-hydroxylase activity|(2S)-flavanone 3-hydroxylase activity|flavanone synthase I activity|flavanone,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)|naringenin 3-hydroxylase activity|flavanone 3-hydroxylase activity|naringenin,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|flavanone 3beta-hydroxylase activity MetaCyc:NARINGENIN-3-DIOXYGENASE-RXN|RHEA:18621|EC:1.14.11.9 molecular_function owl:Class
GO:0032624 biolink:NamedThing interleukin-20 production The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-20 production|interleukin-20 biosynthetic process|interleukin-20 secretion|ZCYTO10 production GO:0042237|GO:0072618 biological_process owl:Class
GO:0052800 biolink:NamedThing bicyclic nitroimidazole catabolic process The chemical reactions and pathways resulting in the breakdown of a bicyclic nitroimidazole. got7fsn_ti bicyclic nitroimidazole catabolism|bicyclic nitroimidazole breakdown|bicyclic nitroimidazole degradation biological_process owl:Class
GO:0052804 biolink:NamedThing nitroimidazole catabolic process The chemical reactions and pathways resulting in the breakdown of nitroimidazoles, imidazole derivatives with a nitro group attached to one ring. got7fsn_ti nitroimidazole degradation|nitroimidazole breakdown|nitroimidazole catabolism biological_process owl:Class
GO:0021579 biolink:NamedThing medulla oblongata morphogenesis The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. got7fsn_ti medulla morphogenesis|myelencephalon morphogenesis biological_process owl:Class
GO:0043640 biolink:NamedThing benzoate catabolic process via hydroxylation The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol. got7fsn_ti benzoate breakdown via hydroxylation|benzoate degradation via hydroxylation MetaCyc:PWY-2503 biological_process owl:Class
GO:0043639 biolink:NamedThing benzoate catabolic process The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid. got7fsn_ti benzoate breakdown|benzoate catabolism|benzoate degradation biological_process owl:Class
GO:0003002 biolink:NamedThing regionalization The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. got7fsn_ti pattern formation biological_process owl:Class
GO:0036023 biolink:NamedThing embryonic skeletal limb joint morphogenesis The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb. got7fsn_ti bf 2011-10-13T04:57:39Z biological_process owl:Class
GO:0036022 biolink:NamedThing limb joint morphogenesis The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner. got7fsn_ti knee morphogenesis|leg joint morphogenesis bf 2011-10-13T04:52:59Z biological_process owl:Class
GO:0097036 biolink:NamedThing regulation of plasma membrane sterol distribution Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane. got7fsn_ti pr 2011-04-08T02:08:08Z biological_process owl:Class
GO:0033203 biolink:NamedThing DNA helicase A complex A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction. got7fsn_ti cellular_component owl:Class
GO:0039687 biolink:NamedThing viral DNA strand displacement replication A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA). got7fsn_ti bf 2013-10-17T14:48:40Z VZ:1940 biological_process owl:Class
GO:0009607 biolink:NamedThing response to biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. got7fsn_ti response to biotic stress Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0061638 biolink:NamedThing CENP-A containing chromatin The specialized chromatin located in the centromeric core region or the entire centromeric region in organisms with point centromeres, which is enriched for CENP-A-containing nucleosomes. This chromatin forms a 3-dimensional structure which provides a platform for kinetochore assembly and microtubule attachment. got7fsn_ti centromeric core region chromatin|centromeric core domain chromatin|chromatin containing CENP-A|nuclear CENP-A containing chromatin dph 2014-08-20T14:06:35Z GO:1904834 cellular_component owl:Class
GO:0000785 biolink:NamedThing chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. got7fsn_ti cytoplasmic chromatin|nuclear chromatin|chromosome scaffold Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. GO:0000789|GO:0005717|GO:0000790 NIF_Subcellular:sao1615953555 cellular_component owl:Class
GO:0003948 biolink:NamedThing N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+). got7fsn_ti aspartylglucosaminidase activity|glycosylasparaginase activity|N-aspartyl-beta-glucosaminidase activity|beta-aspartylglucosylamine amidohydrolase activity|aspartylglucosylaminase activity|N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity|4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity|aspartylglucosylamine deaspartylase activity|aspartylglucosylaminidase activity|aspartylglycosylamine amidohydrolase activity|glucosylamidase activity KEGG_REACTION:R03421|MetaCyc:3.5.1.26-RXN|EC:3.5.1.26|RHEA:11544 molecular_function owl:Class
GO:0047715 biolink:NamedThing hypotaurocyamine kinase activity Catalysis of the reaction: ATP + hypotaurocyamine = N(omega)-phosphohypotaurocyamine + ADP + 2 H(+). got7fsn_ti ATP:hypotaurocyamine N-phosphotransferase activity MetaCyc:HYPOTAUROCYAMINE-KINASE-RXN|RHEA:24008|EC:2.7.3.6|KEGG_REACTION:R03939 molecular_function owl:Class
GO:0005597 biolink:NamedThing collagen type XVI trimer A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils. got7fsn_ti cellular_component owl:Class
GO:0031339 biolink:NamedThing negative regulation of vesicle fusion Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion. got7fsn_ti down-regulation of vesicle fusion|downregulation of vesicle fusion|inhibition of vesicle fusion|down regulation of vesicle fusion biological_process owl:Class
GO:0031338 biolink:NamedThing regulation of vesicle fusion Any process that modulates the frequency, rate or extent of vesicle fusion. got7fsn_ti biological_process owl:Class
GO:0036188 biolink:NamedThing abieta-7,13-dien-18-al dehydrogenase activity Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+. got7fsn_ti abietadienal dehydrogenase bf 2012-04-18T01:46:19Z KEGG_REACTION:R06357|EC:1.2.1.74|MetaCyc:1.2.1.74-RXN|RHEA:26225 molecular_function owl:Class
GO:0050734 biolink:NamedThing hydroxycinnamoyltransferase activity Catalysis of the transfer of a hydroxycinnamoyl group to an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0042555 biolink:NamedThing MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication. got7fsn_ti mini-chromosome maintenance complex cellular_component owl:Class
GO:0006757 biolink:NamedThing ATP generation from ADP The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP. got7fsn_ti ADP phosphorylation biological_process owl:Class
GO:0035249 biolink:NamedThing synaptic transmission, glutamatergic The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. got7fsn_ti glutamatergic synaptic transmission biological_process owl:Class
GO:0001525 biolink:NamedThing angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. got7fsn_ti blood vessel formation from pre-existing blood vessels Wikipedia:Angiogenesis biological_process owl:Class
GO:0052918 biolink:NamedThing dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. got7fsn_ti MetaCyc:RXN-5469|KEGG_REACTION:R06261|RHEA:29539|EC:2.4.1.261 molecular_function owl:Class
GO:0000026 biolink:NamedThing alpha-1,2-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage. got7fsn_ti Reactome:R-HSA-4551297|Reactome:R-HSA-446215|Reactome:R-HSA-446216|Reactome:R-HSA-9035514|Reactome:R-HSA-4720478|Reactome:R-HSA-446187 molecular_function owl:Class
GO:0016243 biolink:NamedThing regulation of autophagosome size Any process that modulates the size of the autophagosome. got7fsn_ti regulation of autophagic vacuole size biological_process owl:Class
GO:1905037 biolink:NamedThing autophagosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome. got7fsn_ti autophagic vacuole organization|initial autophagic vacuole organization bf 2016-03-08T14:18:10Z biological_process owl:Class
GO:0043772 biolink:NamedThing acyl-phosphate glycerol-3-phosphate acyltransferase activity Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate. got7fsn_ti acylphosphate glycerol-3-phosphate acyltransferase activity|acylphosphate:glycerol-3-phosphate acyltransferase activity|acyl-phosphate:glycerol-3-phosphate acyltransferase activity molecular_function owl:Class
GO:0102058 biolink:NamedThing jasmonoyl-leucine synthetase activity Catalysis of the reaction: L-leucine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-leucine. got7fsn_ti MetaCyc:RXN-10459 molecular_function owl:Class
GO:0001654 biolink:NamedThing eye development The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. got7fsn_ti GO:0042460 Wikipedia:Eye_development biological_process owl:Class
GO:0007423 biolink:NamedThing sensory organ development The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure. got7fsn_ti sense organ development biological_process owl:Class
GO:0097657 biolink:NamedThing 3',5'-nucleotide bisphosphate phosphatase activity Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate. got7fsn_ti pr 2014-09-25T11:21:39Z RHEA:43532|EC:3.1.3.97 molecular_function owl:Class
GO:0034862 biolink:NamedThing 2,6-dihydroxybenzothiazole monooxygenase activity Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole. got7fsn_ti UM-BBD_reactionID:r1294 molecular_function owl:Class
GO:0016918 biolink:NamedThing retinal binding Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. got7fsn_ti red-sensitive opsin|vitamin A binding|violet-sensitive opsin|blue-sensitive opsin|opsin|long-wave-sensitive opsin|short-wave-sensitive opsin|retinaldehyde binding|green-sensitive opsin|UV-sensitive opsin molecular_function owl:Class
GO:0047419 biolink:NamedThing N-acetylgalactosamine-6-phosphate deacetylase activity Catalysis of the reaction: H2O + N-acetyl-D-galactosamine 6-phosphate = acetate + D-galactosamine 6-phosphate. got7fsn_ti RHEA:18149|EC:3.5.1.25|MetaCyc:3.5.1.80-RXN molecular_function owl:Class
GO:0004744 biolink:NamedThing retinal isomerase activity Catalysis of the reaction: all-trans-retinal = 11-cis-retinal. got7fsn_ti all-trans-retinal 11-cis-trans-isomerase activity|retinoid isomerase activity|retinene isomerase activity RHEA:24124|KEGG_REACTION:R02126|MetaCyc:RETINAL-ISOMERASE-RXN molecular_function owl:Class
GO:0005834 biolink:NamedThing heterotrimeric G-protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein. got7fsn_ti heterotrimeric G-protein GTPase activity|heterotrimeric G-protein GTPase, alpha-subunit|heterotrimeric G-protein GTPase, beta-subunit|heterotrimeric G-protein GTPase, gamma-subunit See also the molecular function term 'G protein-coupled receptor activity ; GO:0004930'. cellular_component owl:Class
GO:0102705 biolink:NamedThing serine decarboxylase activity Catalysis of the reaction: H+ + L-serine <=> ethanolaminium(1+) + carbon dioxide. got7fsn_ti MetaCyc:RXN-5641|RHEA:45824 molecular_function owl:Class
GO:0070375 biolink:NamedThing ERK5 cascade An intracellular protein kinase cascade containing at least ERK5 (also called BMK1; a MAPK), a MEK (a MAPKK) and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. got7fsn_ti ERK5 signaling pathway|BMK1 cascade|BMK signalling pathway|extracellular signal-regulated kinase 5 cascade|BMK cascade|big MAP kinase signaling cascade|MAPK7 cascade|BMK signaling pathway biological_process owl:Class
GO:0000165 biolink:NamedThing MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. got7fsn_ti MAPK signal transduction|mitogen-activated protein kinase cascade|MAP kinase kinase kinase cascade|ERK/MAPK cascade|MAPK signalling|MAP kinase cascade|MAPK signaling|MAPKKK cascade|MAPKKK cascade during sporulation MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. GO:0007255 Wikipedia:MAPK_cascade|Wikipedia:Mitogen-activated_protein_kinase biological_process owl:Class
GO:0090707 biolink:NamedThing establishment of plant organ orientation The process that determines the orientation of a plant organ or tissue with reference to an axis. got7fsn_ti tb 2016-10-05T12:42:47Z biological_process owl:Class
GO:0098776 biolink:NamedThing protein transport across the cell outer membrane The directed movement of proteins across the cell outer membrane. got7fsn_ti biological_process owl:Class
GO:0061580 biolink:NamedThing colon epithelial cell migration The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism. got7fsn_ti dph 2013-12-23T07:26:54Z biological_process owl:Class
GO:0061582 biolink:NamedThing intestinal epithelial cell migration The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism. got7fsn_ti dph 2013-12-23T07:30:55Z biological_process owl:Class
GO:0036143 biolink:NamedThing kringle domain binding Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors. got7fsn_ti bf 2012-03-09T09:49:43Z molecular_function owl:Class
GO:0009595 biolink:NamedThing detection of biotic stimulus The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal. got7fsn_ti perception of biotic stimulus GO:0009596 biological_process owl:Class
GO:0034928 biolink:NamedThing 1-hydroxypyrene 6,7-monooxygenase activity Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O. got7fsn_ti UM-BBD_reactionID:r0946 molecular_function owl:Class
GO:0042538 biolink:NamedThing hyperosmotic salinity response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. got7fsn_ti salt tolerance|response to hyperosmotic salt stress biological_process owl:Class
GO:0031813 biolink:NamedThing P2Y2 nucleotide receptor binding Binding to a P2Y2 nucleotide receptor. got7fsn_ti P2Y2 nucleotide receptor ligand molecular_function owl:Class
GO:0042622 biolink:NamedThing photoreceptor outer segment membrane The membrane surrounding the outer segment of a vertebrate photoreceptor. got7fsn_ti cellular_component owl:Class
GO:0060170 biolink:NamedThing ciliary membrane The portion of the plasma membrane surrounding a cilium. got7fsn_ti flagellum membrane|flagellar membrane|cilium membrane|cilial membrane Note that cilia and eukaryotic flagella are deemed to be equivalent. GO:0020017 cellular_component owl:Class
GO:0017087 biolink:NamedThing mitochondrial processing peptidase complex A protein complex consisting of a regulatory subunit (alpha-MPP) and a catalytic subunit (beta-MPP) that catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion. got7fsn_ti Note that monomeric mitochondrial processing peptidases have been observed. cellular_component owl:Class
GO:0004691 biolink:NamedThing cAMP-dependent protein kinase activity cAMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. got7fsn_ti 3',5' cAMP-dependent protein kinase activity|ATP:protein phosphotransferase (cAMP-dependent) activity|3',5'-cAMP-dependent protein kinase activity|cyclic AMP-dependent protein kinase activity|PKA|STK22|cAMP-dependent protein kinase, intrinsic catalyst activity|protein kinase A activity|AMPK|PKA C|adenosine 3',5'-cyclophosphate-dependent protein kinase activity This reaction requires the presence of cAMP. GO:0008602 Reactome:R-HSA-177275|Reactome:R-HSA-163672|Reactome:R-HSA-163676|Reactome:R-HSA-5610717|Reactome:R-HSA-5610720|Reactome:R-HSA-163773|Reactome:R-HSA-913451|Reactome:R-HSA-5687088|Reactome:R-HSA-5610741|EC:2.7.11.11|Reactome:R-HSA-5617179|Reactome:R-HSA-177284|Reactome:R-HSA-5617182|Reactome:R-HSA-432232|MetaCyc:2.7.11.11-RXN molecular_function owl:Class
GO:0004690 biolink:NamedThing cyclic nucleotide-dependent protein kinase activity cNMP-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. got7fsn_ti This reaction requires the presence of a cyclic nucleotide. molecular_function owl:Class
GO:0097323 biolink:NamedThing B cell adhesion The attachment of a B cell to another cell via adhesion molecules. got7fsn_ti pr 2012-06-06T01:59:19Z biological_process owl:Class
GO:0060008 biolink:NamedThing Sertoli cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Sertoli cell. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. got7fsn_ti biological_process owl:Class
GO:1990836 biolink:NamedThing lysosomal matrix A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome. got7fsn_ti sl 2015-08-25T17:04:12Z cellular_component owl:Class
GO:0047941 biolink:NamedThing glucuronolactone reductase activity Catalysis of the reaction: L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + H(+) + NADPH. got7fsn_ti KEGG_REACTION:R03183|MetaCyc:GLUCURONOLACTONE-REDUCTASE-RXN|EC:1.1.1.20|RHEA:18925 molecular_function owl:Class
GO:0075183 biolink:NamedThing infection cushion formation The process in which an organized mass of hyphae is formed and numerous infective hyphae develop from the hyphae mass. got7fsn_ti infection cushion formation on or near host biological_process owl:Class
GO:0097359 biolink:NamedThing UDP-glucosylation The covalent attachment of a UDP-glucose residue to a substrate molecule. got7fsn_ti pr 2012-07-06T02:26:35Z biological_process owl:Class
GO:0006011 biolink:NamedThing UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. got7fsn_ti UDP-glucose metabolism biological_process owl:Class
GO:0048309 biolink:NamedThing endoplasmic reticulum inheritance The partitioning of endoplasmic reticulum between daughter cells at cell division. got7fsn_ti ER inheritance biological_process owl:Class
GO:0043178 biolink:NamedThing alcohol binding Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group. got7fsn_ti molecular_function owl:Class
GO:1990605 biolink:NamedThing GU repeat RNA binding Binding to an RNA molecule containing GU repeats. got7fsn_ti al 2015-01-13T18:18:01Z molecular_function owl:Class
GO:0018639 biolink:NamedThing xylene monooxygenase activity Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol. got7fsn_ti UM-BBD_enzymeID:e0172|EC:1.14.13.- molecular_function owl:Class
GO:0018306 biolink:NamedThing iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide RESID:AA0289 biological_process owl:Class
GO:0018283 biolink:NamedThing iron incorporation into metallo-sulfur cluster The incorporation of iron into a metallo-sulfur cluster. got7fsn_ti iron incorporation into metallo-sulphur cluster biological_process owl:Class
GO:0017194 biolink:NamedThing N-terminal peptidyl-isoleucine acetylation The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed. got7fsn_ti RESID:AA0047 biological_process owl:Class
GO:0035525 biolink:NamedThing NF-kappaB p50/p65 complex A heterodimer of NF-kappa B p50 and p65 subunits. got7fsn_ti NF-kappa p105/RelA complex|NF-kappa B1/RelA complex|NF-kappa p50/RelA complex|NF-kappa B1/p65 complex|NF-kappa p105/p65 complex Note that the p50 subunit is encoded by NFKB1 gene in human and the p65 subunit is encoded by the RELA gene in human. Similar nomenclature is used in other vertebrate species. The p50 subunit has a precursor form p105 in some publications. bf 2010-05-05T10:45:13Z cellular_component owl:Class
GO:0071159 biolink:NamedThing NF-kappaB complex A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression. got7fsn_ti mah 2009-11-17T02:03:34Z cellular_component owl:Class
GO:0034549 biolink:NamedThing N-cyclopropylammelide alkylamino hydrolase activity Catalysis of the reaction: N-cyclopropylammelide + H2O = cyclopropylamine + cyanuric acid. got7fsn_ti UM-BBD_reactionID:r0827|KEGG_REACTION:R06972|MetaCyc:RXN-8020 molecular_function owl:Class
GO:0048262 biolink:NamedThing determination of dorsal/ventral asymmetry Determination of asymmetry from the dorsal to the ventral side; as, the dorsoventral axis. got7fsn_ti determination of adaxial/abaxial asymmetry|determination of dorsal-ventral asymmetry|determination of dorsoventral asymmetry biological_process owl:Class
GO:0062082 biolink:NamedThing HLA-E specific inhibitory MHC class Ib receptor activity Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. got7fsn_ti dph 2018-10-15T15:06:22Z molecular_function owl:Class
GO:0062080 biolink:NamedThing inhibitory MHC class Ib receptor activity Combining with a MHC class Ib protein complex to mediate signaling that inhibits activation of a lymphocyte. got7fsn_ti dph 2018-10-15T15:03:44Z molecular_function owl:Class
GO:0046558 biolink:NamedThing arabinan endo-1,5-alpha-L-arabinosidase activity Catalysis of the endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5) arabinans. got7fsn_ti 1,5-alpha-L-arabinan 1,5-alpha-L-arabinanohydrolase activity|endo-arabanase activity|endo-1,5-alpha-L-arabinanase activity|endo-alpha-1,5-arabanase activity MetaCyc:3.2.1.99-RXN|EC:3.2.1.99 molecular_function owl:Class
GO:0044529 biolink:NamedThing regulation of mitochondrial rRNA stability Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs. got7fsn_ti jl 2012-03-15T03:22:19Z biological_process owl:Class
GO:0044357 biolink:NamedThing regulation of rRNA stability Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs. got7fsn_ti regulation of ribosomal RNA stability jl 2011-08-31T09:57:54Z biological_process owl:Class
GO:1990427 biolink:NamedThing stereocilia tip-link density An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane. got7fsn_ti sl 2014-07-25T20:55:36Z cellular_component owl:Class
GO:0101012 biolink:NamedThing inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate 1-diphosphatase activity Catalysis of the reaction: myo-inositol 1,5-bisdiphosphate 2,3,4,6-tetrakisphosphate + H2O = myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + phosphate. got7fsn_ti inositol 1,5-bispyrophosphate 2,3,4,6-tetrakisphosphate 1-pyrophosphatase activity molecular_function owl:Class
GO:0003348 biolink:NamedThing cardiac endothelial cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. got7fsn_ti dph 2009-12-01T11:12:05Z biological_process owl:Class
GO:0035051 biolink:NamedThing cardiocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual. got7fsn_ti cardiac cell differentiation|heart cell differentiation biological_process owl:Class
GO:0042393 biolink:NamedThing histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. got7fsn_ti histone-specific chaperone activity molecular_function owl:Class
GO:0000009 biolink:NamedThing alpha-1,6-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage. got7fsn_ti 1,6-alpha-mannosyltransferase activity Reactome:R-HSA-449718|EC:2.4.1.232 molecular_function owl:Class
GO:0140065 biolink:NamedThing peptide butyryltransferase activity Catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide. got7fsn_ti protein butyryltransferase activity pg 2017-07-20T16:46:49Z molecular_function owl:Class
GO:0097490 biolink:NamedThing sympathetic neuron projection extension Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. got7fsn_ti sympathetic neuron protrusion extension|sympathetic neurite extension|sympathetic neuron process extension|sympathetic neuronal cell projection extension pr 2013-07-10T11:47:53Z biological_process owl:Class
GO:1990138 biolink:NamedThing neuron projection extension Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. got7fsn_ti neurite extension|neuron protrusion extension|neuronal cell projection extension|neuron process extension pr 2013-07-08T08:40:45Z biological_process owl:Class
GO:0090534 biolink:NamedThing calcium ion-transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in). got7fsn_ti tb 2013-02-07T15:52:58Z cellular_component owl:Class
GO:0090533 biolink:NamedThing cation-transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). got7fsn_ti tb 2013-02-07T15:50:28Z cellular_component owl:Class
GO:0044544 biolink:NamedThing envenomation resulting in plasminogen activation in other organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide. got7fsn_ti jl 2012-03-22T11:54:49Z biological_process owl:Class
GO:0044484 biolink:NamedThing envenomation resulting in fibrinolysis in other organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism. got7fsn_ti jl 2012-01-26T03:26:33Z biological_process owl:Class
GO:0003950 biolink:NamedThing NAD+ ADP-ribosyltransferase activity Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. got7fsn_ti poly(ADP-ribose)polymerase activity|NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity|poly(ADP-ribose) synthetase activity|poly(ADP-ribose) synthase activity|ADP-ribosyltransferase (polymerizing) activity|NAD ADP-ribosyltransferase activity|poly(adenosine diphosphate ribose) polymerase activity Reactome:R-HSA-5687653|MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN|EC:2.4.2.30|Reactome:R-HSA-5688276|Reactome:R-HSA-8938073|Reactome:R-HSA-2187325|Reactome:R-HSA-5651723|Reactome:R-HSA-9686061|Reactome:R-HSA-8948800|Reactome:R-HSA-9694773|Reactome:R-HSA-3640858 molecular_function owl:Class
GO:0018792 biolink:NamedThing bis(4-chlorophenyl)acetate decarboxylase activity Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM. got7fsn_ti DDA decarboxylase activity UM-BBD_reactionID:r0520 molecular_function owl:Class
GO:0060141 biolink:NamedThing positive regulation of syncytium formation by virus The process in which a virus increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. got7fsn_ti syncytium formation induced by viral infection biological_process owl:Class
GO:0060140 biolink:NamedThing modulation by virus of syncytium formation via plasma membrane fusion The formation in a cell that has been targeted by a virus of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. got7fsn_ti biological_process owl:Class
GO:0030986 biolink:NamedThing low molecular weight kininogen binding Binding to a kininogen of low molecular mass. got7fsn_ti LMW kininogen binding|LK binding molecular_function owl:Class
GO:0030984 biolink:NamedThing kininogen binding Binding to a kininogen, a kinin precursor. got7fsn_ti molecular_function owl:Class
GO:0006767 biolink:NamedThing water-soluble vitamin metabolic process The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water. got7fsn_ti water-soluble vitamin metabolism biological_process owl:Class
GO:0061674 biolink:NamedThing gap filling involved in double-strand break repair via nonhomologous end joining Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining. got7fsn_ti dph 2015-01-05T10:07:32Z biological_process owl:Class
GO:0021699 biolink:NamedThing cerebellar cortex maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. got7fsn_ti biological_process owl:Class
GO:0043303 biolink:NamedThing mast cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell. got7fsn_ti mast cell granule exocytosis https://github.com/geneontology/go-ontology/issues/15943 biological_process owl:Class
GO:0019601 biolink:NamedThing toluene oxidation via 2-hydroxytoluene The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol). got7fsn_ti MetaCyc:TOLUENE-DEG-2-OH-PWY biological_process owl:Class
GO:0006471 biolink:NamedThing protein ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. got7fsn_ti protein amino acid ADP-ribosylation RESID:AA0040|RESID:AA0231|RESID:AA0295|RESID:AA0169|RESID:AA0237|RESID:AA0168 biological_process owl:Class
GO:0018313 biolink:NamedThing peptide cross-linking via L-alanyl-5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water. got7fsn_ti RESID:AA0187 biological_process owl:Class
GO:0018253 biolink:NamedThing peptide cross-linking via 5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde. got7fsn_ti biosynthesis of protein-protein cross-link via 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine RESID:AA0187|RESID:AA0184|RESID:AA0188 biological_process owl:Class
GO:0002485 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules. got7fsn_ti TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway|TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway|endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent biological_process owl:Class
GO:0002484 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class I via ER pathway biological_process owl:Class
GO:0102035 biolink:NamedThing isobutyryl-CoA:FAD oxidoreductase activity Catalysis of the reaction: H+ + isobutyryl-CoA + FAD <=> methacrylyl-CoA + FADH2. got7fsn_ti EC:1.3.8.5|MetaCyc:MEPROPCOA-FAD-RXN molecular_function owl:Class
GO:0048235 biolink:NamedThing pollen sperm cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a haploid sperm cell within the plant gametophyte. got7fsn_ti sperm cell differentiation|male gamete generation|male gametophyte sperm cell differentiation GO:0048234 biological_process owl:Class
GO:0005229 biolink:NamedThing intracellular calcium activated chloride channel activity Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. got7fsn_ti Reactome:R-HSA-2744242|Reactome:R-HSA-9659568|Reactome:R-HSA-2744361|Reactome:R-HSA-2684901 molecular_function owl:Class
GO:0036153 biolink:NamedThing triglyceride acyl-chain remodeling Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains. got7fsn_ti triacylglycerol acyl-chain remodeling bf 2012-03-14T02:49:05Z biological_process owl:Class
GO:0036155 biolink:NamedThing acylglycerol acyl-chain remodeling Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains. got7fsn_ti glyceride acyl-chain remodeling bf 2012-03-14T02:55:00Z biological_process owl:Class
GO:0045481 biolink:NamedThing 6-endo-hydroxycineole dehydrogenase activity Catalysis of the reaction: 6-endo-hydroxycineole + NAD(+) = 6-oxocineole + H(+) + NADH. got7fsn_ti 6-endo-hydroxycineole:NAD+ 6-oxidoreductase activity EC:1.1.1.241|KEGG_REACTION:R02994|MetaCyc:6-ENDO-HYDROXYCINEOLE-DEHYDROGENASE-RXN|RHEA:11736 molecular_function owl:Class
GO:0010500 biolink:NamedThing transmitting tissue development The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary. got7fsn_ti biological_process owl:Class
GO:0048467 biolink:NamedThing gynoecium development The process whose specific outcome is the progression of the gynoecium over time, from its formation to the mature structure. The gynoecium is the collective name for the carpels of a flower. got7fsn_ti pistil development biological_process owl:Class
GO:0051742 biolink:NamedThing 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-methyl-6-solanyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-solanyl-1,4-benzoquinone + S-adenosyl-homocysteine. got7fsn_ti MSBQ methyltransferase activity MetaCyc:RXN-2762|RHEA:37999 molecular_function owl:Class
GO:0005289 biolink:NamedThing high-affinity arginine transmembrane transporter activity Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high-affinity arginine transporter activity|high affinity arginine transmembrane transporter activity molecular_function owl:Class
GO:0008767 biolink:NamedThing UDP-galactopyranose mutase activity Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose. got7fsn_ti UDPgalactopyranose mutase activity|UDP-D-galactopyranose furanomutase activity RHEA:24132|EC:5.4.99.9|MetaCyc:GALPMUT-RXN molecular_function owl:Class
GO:0016866 biolink:NamedThing intramolecular transferase activity Catalysis of the transfer of a functional group from one position to another within a single molecule. got7fsn_ti mutase activity|intramolecular transferase activity, transferring other groups EC:5.4.-.- molecular_function owl:Class
GO:0099703 biolink:NamedThing induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission. got7fsn_ti biological_process owl:Class
GO:0099533 biolink:NamedThing positive regulation of presynaptic cytosolic calcium concentration Any process that increases the concentration of calcium ions in the presynaptic cytosol. got7fsn_ti biological_process owl:Class
GO:0036437 biolink:NamedThing Isw1b complex An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p. got7fsn_ti bf 2013-09-18T16:53:07Z cellular_component owl:Class
GO:0016587 biolink:NamedThing Isw1 complex A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure. got7fsn_ti cellular_component owl:Class
GO:0007087 biolink:NamedThing mitotic nuclear pore complex reassembly The cell cycle process in which nuclear pore complexes reform during mitotic cell division. got7fsn_ti biological_process owl:Class
GO:0006900 biolink:NamedThing vesicle budding from membrane The evagination of a membrane, resulting in formation of a vesicle. got7fsn_ti nonselective vesicle assembly|membrane evagination|single-organism membrane budding|vesicle biosynthesis|vesicle formation|vesicle budding|single organism membrane budding jl 2013-12-19T15:26:17Z GO:0006902|GO:1902591 biological_process owl:Class
GO:0016050 biolink:NamedThing vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle. got7fsn_ti vesicle organisation|vesicle organization and biogenesis biological_process owl:Class
GO:0001194 biolink:NamedThing maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter. got7fsn_ti maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter krc 2011-09-02T02:37:59Z biological_process owl:Class
GO:0018625 biolink:NamedThing naphthalene 1,2-dioxygenase activity Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+. got7fsn_ti naphthalene dioxygenase activity|naphthalene oxygenase activity|naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating) EC:1.14.12.12|RHEA:19173|UM-BBD_enzymeID:e0002|MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN molecular_function owl:Class
GO:0075733 biolink:NamedThing intracellular transport of virus The directed movement of a virus, or part of a virus, within the host cell. got7fsn_ti egress of virus within host cell|movement of virus within host cell|viral genome transport in host cell|intracellular transport of viral material|intracellular virion transport|viral egress jl 2009-05-01T04:01:33Z GO:0046788|GO:0046795|GO:0046796 biological_process owl:Class
GO:0047805 biolink:NamedThing cytidylate cyclase activity Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H(+). got7fsn_ti cytidylyl cyclase activity|cytidyl cyclase activity|3'5'-cyclic-CMP synthase activity|CTP diphosphate-lyase (cyclizing)|CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)|3',5'-cyclic-CMP synthase activity MetaCyc:CYTIDYLATE-CYCLASE-RXN|KEGG_REACTION:R00574|RHEA:14737|EC:4.6.1.6 molecular_function owl:Class
GO:1990946 biolink:NamedThing meiosis I/meiosis II transition The cell cycle process in which a cell progresses from meiosis I to meiosis II. got7fsn_ti vw 2016-04-21T13:01:07Z biological_process owl:Class
GO:0044771 biolink:NamedThing meiotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase. got7fsn_ti cell cycle transition jl 2013-02-28T13:08:17Z biological_process owl:Class
GO:0048367 biolink:NamedThing shoot system development The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure. got7fsn_ti shoot development GO:0022621 biological_process owl:Class
GO:0051523 biolink:NamedThing cell growth mode switching, monopolar to bipolar The process in which a cell switches from monopolar cell growth to bipolar cell growth. got7fsn_ti NETO|new end take off biological_process owl:Class
GO:0061171 biolink:NamedThing establishment of bipolar cell polarity The specification and formation of bipolar intracellular organization or cell growth patterns. Bipolar organization is the organization that is a mirror image along an axis from a plane. got7fsn_ti dph 2010-06-30T08:49:38Z biological_process owl:Class
GO:0015544 biolink:NamedThing phenyl propionate uniporter activity Enables the transfer of phenyl propionate from one side of a membrane to the other. got7fsn_ti phenyl propionate permease activity molecular_function owl:Class
GO:0015292 biolink:NamedThing uniporter activity Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. got7fsn_ti single-species transporter activity|facilitated diffusion carrier|uniport molecular_function owl:Class
GO:0075054 biolink:NamedThing modulation of penetration peg formation Any process that modulates the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation of symbiont penetration peg initiation|modulation of symbiont penetration peg formation for entry into host https://github.com/geneontology/go-ontology/issues/18557 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. GO:0075058 biological_process owl:Class
GO:0052372 biolink:NamedThing modulation by symbiont of entry into host Any process in which an organism modulates the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modulation by organism of entry into other organism during symbiotic interaction|modulation by symbiont of entry into host|regulation by organism of entry into other organism involved in symbiotic interaction|regulation by organism of entry into other organism during symbiotic interaction https://github.com/geneontology/go-ontology/issues/19027 GO:0052371 biological_process owl:Class
GO:0030642 biolink:NamedThing cellular sulfate ion homeostasis Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell. got7fsn_ti sulphate ion homeostasis biological_process owl:Class
GO:0039556 biolink:NamedThing MDA-5 binding Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA. got7fsn_ti MDA5 binding bf 2012-03-09T04:12:33Z molecular_function owl:Class
GO:0002512 biolink:NamedThing central T cell tolerance induction Tolerance induction of T cells in the thymus. got7fsn_ti central T-cell tolerance induction|central T-lymphocyte tolerance induction|central T lymphocyte tolerance induction biological_process owl:Class
GO:0006058 biolink:NamedThing mannoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of a mannoprotein, a protein that contains covalently bound mannose residues. got7fsn_ti mannoprotein degradation|mannoprotein catabolism|mannoprotein breakdown biological_process owl:Class
GO:0006516 biolink:NamedThing glycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. got7fsn_ti glycoprotein catabolism|glycoprotein degradation|glycoprotein breakdown biological_process owl:Class
GO:0004356 biolink:NamedThing glutamate-ammonia ligase activity Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate. got7fsn_ti glutamylhydroxamic synthetase activity|L-glutamine synthetase activity|glutamine synthetase activity|L-glutamate:ammonia ligase (ADP-forming) Reactome:R-HSA-70606|KEGG_REACTION:R00253|MetaCyc:GLUTAMINESYN-RXN|EC:6.3.1.2|RHEA:16169 molecular_function owl:Class
GO:0016211 biolink:NamedThing ammonia ligase activity Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. got7fsn_ti EC:6.3.1.- molecular_function owl:Class
GO:0008113 biolink:NamedThing peptide-methionine (S)-S-oxide reductase activity Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. got7fsn_ti peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity|methionine S-oxide reductase (S-form oxidizing) activity|MsrA|methionine sulphoxide reductase A activity|peptide-methionine-(S)-S-oxide reductase activity|peptide Met(O) reductase activity|protein-methionine-S-oxide reductase activity|methionine sulfoxide (protein) reductase activity|methionine sulfoxide reductase activity|peptide methionine sulfoxide reductase activity|methionine sulfoxide reductase A activity|methionine S-oxide reductase activity GO:0033742|GO:0072561 Reactome:R-HSA-1222363|RHEA:14217|MetaCyc:RXN-8668|Reactome:R-HSA-5676940|MetaCyc:RXN-8669|EC:1.8.4.11 molecular_function owl:Class
GO:0004398 biolink:NamedThing histidine decarboxylase activity Catalysis of the reaction: L-histidine = histamine + CO2. got7fsn_ti L-histidine decarboxylase activity|L-histidine carboxy-lyase (histamine-forming)|L-histidine carboxy-lyase activity EC:4.1.1.22|Reactome:R-HSA-977301|RHEA:20840|MetaCyc:HISTIDINE-DECARBOXYLASE-RXN molecular_function owl:Class
GO:0042285 biolink:NamedThing xylosyltransferase activity Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid. got7fsn_ti molecular_function owl:Class
GO:0045807 biolink:NamedThing positive regulation of endocytosis Any process that activates or increases the frequency, rate or extent of endocytosis. got7fsn_ti up regulation of endocytosis|up-regulation of endocytosis|stimulation of endocytosis|activation of endocytosis|upregulation of endocytosis biological_process owl:Class
GO:0071476 biolink:NamedThing cellular hypotonic response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. got7fsn_ti cellular hypo-osmotic response mah 2009-12-18T11:52:59Z biological_process owl:Class
GO:0018500 biolink:NamedThing trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene. got7fsn_ti UM-BBD_reactionID:r0575 molecular_function owl:Class
GO:0002931 biolink:NamedThing response to ischemia Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. got7fsn_ti Ischemia always results in hypoxia; however, hypoxia can occur without ischemia. hjd 2012-04-20T02:57:51Z biological_process owl:Class
GO:0030678 biolink:NamedThing mitochondrial ribonuclease P complex A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species. The complex contains a single RNA molecule and a single protein molecule in yeast (PMID:12045094), but comprises three proteins and lacks an RNA component in humans. got7fsn_ti mitochondrial RNase P complex https://github.com/geneontology/go-ontology/issues/20778 cellular_component owl:Class
GO:0008654 biolink:NamedThing phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. got7fsn_ti phospholipid synthesis|phospholipid biosynthesis|phospholipid formation|phospholipid anabolism MetaCyc:PHOSLIPSYN-PWY|MetaCyc:LIPASYN-PWY|MetaCyc:PHOSLIPSYN2-PWY biological_process owl:Class
GO:0050934 biolink:NamedThing late stripe melanocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development). got7fsn_ti late stripe melanocyte cell differentiation|late stripe melanophore differentiation biological_process owl:Class
GO:0030318 biolink:NamedThing melanocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a melanocyte. got7fsn_ti melanophore differentiation|melanocyte cell differentiation biological_process owl:Class
GO:0071483 biolink:NamedThing cellular response to blue light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. got7fsn_ti cellular response to blue light stimulus mah 2009-12-18T02:09:48Z biological_process owl:Class
GO:0018167 biolink:NamedThing protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine. got7fsn_ti RESID:AA0259 biological_process owl:Class
GO:0017011 biolink:NamedThing protein-phycoerythrobilin linkage The linkage of the chromophore phycoerythrobilin to phycoerythrins. got7fsn_ti RESID:AA0132 biological_process owl:Class
GO:0008742 biolink:NamedThing L-ribulose-phosphate 4-epimerase activity Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate. got7fsn_ti L-ribulose 5-phosphate 4-epimerase activity|phosphoribulose isomerase activity|ribulose phosphate 4-epimerase activity|L-ribulose-5-phosphate 4-epimerase|L-ru5P activity|AraD|L-Ru5P EC:5.1.3.4|MetaCyc:RIBULPEPIM-RXN|RHEA:22368|KEGG_REACTION:R05850 molecular_function owl:Class
GO:0033952 biolink:NamedThing iota-carrageenase activity Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans. got7fsn_ti iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting) activity MetaCyc:3.2.1.157-RXN|EC:3.2.1.157 molecular_function owl:Class
GO:0047149 biolink:NamedThing thetin-homocysteine S-methyltransferase activity Catalysis of the reaction: L-homocysteine + dimethylsulfonioacetate = (methylthio)acetate + L-methionine + H(+). got7fsn_ti thetin-homocysteine methylpherase activity|dimethylthetin-homocysteine methyltransferase activity|dimethylsulfonioacetate:L-homocysteine S-methyltransferase activity KEGG_REACTION:R04153|EC:2.1.1.3|RHEA:22788|MetaCyc:2.1.1.3-RXN molecular_function owl:Class
GO:0051962 biolink:NamedThing positive regulation of nervous system development Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. got7fsn_ti up regulation of nervous system development|up-regulation of nervous system development|upregulation of nervous system development|activation of nervous system development|stimulation of nervous system development biological_process owl:Class
GO:0043430 biolink:NamedThing 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. got7fsn_ti 2-decaprenyl-6-methoxy-1,4-benzoquinone methylase activity Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. RHEA:44764|Reactome:R-HSA-2162188 molecular_function owl:Class
GO:0035601 biolink:NamedThing protein deacylation The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid. got7fsn_ti protein amino acid deacylation bf 2010-11-15T11:06:15Z biological_process owl:Class
GO:0098732 biolink:NamedThing macromolecule deacylation The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule. got7fsn_ti biological_process owl:Class
GO:0036308 biolink:NamedThing 16S rRNA (guanine(1516)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine. got7fsn_ti bf 2012-08-08T14:17:44Z molecular_function owl:Class
GO:0008990 biolink:NamedThing rRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. got7fsn_ti ribosomal ribonucleate guanine-2-methyltransferase activity|S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity|S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity EC:2.1.1.52|MetaCyc:RRNA-GUANINE-N2--METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0043424 biolink:NamedThing protein histidine kinase binding Binding to a protein histidine kinase. got7fsn_ti histidine-protein kinase binding|histidine kinase binding|protein-histidine kinase binding molecular_function owl:Class
GO:0043175 biolink:NamedThing RNA polymerase core enzyme binding Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. got7fsn_ti molecular_function owl:Class
GO:0070063 biolink:NamedThing RNA polymerase binding Binding to an RNA polymerase molecule or complex. got7fsn_ti molecular_function owl:Class
GO:0003191 biolink:NamedThing coronary sinus valve formation The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti dph 2009-10-08T01:09:04Z biological_process owl:Class
GO:0003188 biolink:NamedThing heart valve formation The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti dph 2009-10-08T12:20:15Z biological_process owl:Class
GO:0008853 biolink:NamedThing exodeoxyribonuclease III activity Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. got7fsn_ti Escherichia coli exonuclease III|E. coli exonuclease III activity|exonuclease III activity|E. coli exonuclease III|endoribonuclease III MetaCyc:3.1.11.2-RXN|EC:3.1.11.2 molecular_function owl:Class
GO:0016895 biolink:NamedThing exodeoxyribonuclease activity, producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. got7fsn_ti exonuclease VIII activity|exodeoxyribonuclease activity, producing 5' phosphomonoesters GO:0008858 EC:3.1.11.- molecular_function owl:Class
GO:0060875 biolink:NamedThing lateral semicircular canal development The progession of the lateral semicircular canal from its initial formation to the mature structure. got7fsn_ti dph 2009-08-13T09:43:25Z biological_process owl:Class
GO:0060872 biolink:NamedThing semicircular canal development The progression of the semicircular canal from its initial formation to the mature structure. got7fsn_ti dph 2009-08-13T09:36:37Z biological_process owl:Class
GO:0016995 biolink:NamedThing cholesterol oxidase activity Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2. got7fsn_ti 3beta-hydroxy steroid oxidoreductase activity|cholesterol-O2 oxidoreductase activity|cholesterol- O2 oxidoreductase activity|3beta-hydroxysteroid:oxygen oxidoreductase activity|cholesterol-O(2) oxidoreductase activity|cholesterol:oxygen oxidoreductase activity MetaCyc:CHOLESTEROL-OXIDASE-RXN|EC:1.1.3.6|RHEA:32183|KEGG_REACTION:R01459 molecular_function owl:Class
GO:0060204 biolink:NamedThing clathrin-sculpted glutamate transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted glutamate transport vesicle. got7fsn_ti clathrin sculpted glutamate transport vesicle lumen|clathrin sculpted glutamate constitutive secretory pathway transport vesicle lumen cellular_component owl:Class
GO:0036150 biolink:NamedThing phosphatidylserine acyl-chain remodeling Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. got7fsn_ti phosphatidyl-L-serine acyl-chain remodeling bf 2012-03-14T01:35:44Z biological_process owl:Class
GO:0006658 biolink:NamedThing phosphatidylserine metabolic process The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes. got7fsn_ti phosphatidylserine metabolism biological_process owl:Class
GO:0050001 biolink:NamedThing D-glutaminase activity Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate. got7fsn_ti D-glutamine amidohydrolase activity EC:3.5.1.35|MetaCyc:D-GLUTAMINASE-RXN|RHEA:22840 molecular_function owl:Class
GO:0018244 biolink:NamedThing protein N-linked glycosylation via tryptophan The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue. got7fsn_ti protein amino acid N-linked glycosylation via tryptophan RESID:AA0156 biological_process owl:Class
GO:0018211 biolink:NamedThing peptidyl-tryptophan modification The chemical alteration of a tryptophan residue in a peptide. got7fsn_ti biological_process owl:Class
GO:0106366 biolink:NamedThing guanosine kinase activity Catalysis of the reaction: ATP + guanosine = ADP + GMP. got7fsn_ti hjd 2021-02-23T21:18:12Z RHEA:27710|EC:2.7.1.73 molecular_function owl:Class
GO:0005633 biolink:NamedThing ascus lipid droplet Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins. got7fsn_ti ascus lipid particle cellular_component owl:Class
GO:0005811 biolink:NamedThing lipid droplet An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. got7fsn_ti lipid body|adiposome|lipid particle Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. cellular_component owl:Class
GO:0014815 biolink:NamedThing initiation of skeletal muscle satellite cell activation by growth factor signaling, involved in skeletal muscle regeneration Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. got7fsn_ti biological_process owl:Class
GO:0014718 biolink:NamedThing positive regulation of satellite cell activation involved in skeletal muscle regeneration Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. got7fsn_ti biological_process owl:Class
GO:0048677 biolink:NamedThing axon extension involved in regeneration Long distance growth of a single axon process involved in regeneration of the neuron. got7fsn_ti biological_process owl:Class
GO:0048682 biolink:NamedThing sprouting of injured axon The process involved in sprouting of an injured axon. got7fsn_ti biological_process owl:Class
GO:0052173 biolink:NamedThing response to defenses of other organism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the defenses of another organism. got7fsn_ti response to defenses of other organism during symbiotic interaction|response to defenses of other organism involved in symbiotic interaction https://github.com/geneontology/go-ontology/issues/17930 biological_process owl:Class
GO:0018791 biolink:NamedThing 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate. got7fsn_ti UM-BBD_reactionID:r0398 molecular_function owl:Class
GO:0047775 biolink:NamedThing citramalate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + citramalate = acetate + (3S)-citramalyl-CoA. got7fsn_ti acetyl-CoA:citramalate CoA-transferase activity MetaCyc:CITRAMALATE-COA-TRANSFERASE-RXN|RHEA:17621|EC:2.8.3.11 molecular_function owl:Class
GO:0008410 biolink:NamedThing CoA-transferase activity Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). got7fsn_ti Reactome:R-HSA-70713|EC:2.8.3.- molecular_function owl:Class
GO:0007446 biolink:NamedThing imaginal disc growth The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form. got7fsn_ti biological_process owl:Class
GO:0060388 biolink:NamedThing vitelline envelope A glycoprotein-based structure that lies outside the plasma membrane and surrounds the egg before fertilization. got7fsn_ti fertilization membrane cellular_component owl:Class
GO:0035805 biolink:NamedThing egg coat A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. got7fsn_ti zona pellucida|vitelline membrane bf 2011-04-19T02:07:23Z cellular_component owl:Class
GO:0018045 biolink:NamedThing C-terminal peptidyl-lysine amidation The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0092 biological_process owl:Class
GO:0033179 biolink:NamedThing proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. got7fsn_ti cellular_component owl:Class
GO:0072763 biolink:NamedThing cellular response to hesperadin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus. got7fsn_ti mah 2012-11-09T11:50:58Z biological_process owl:Class
GO:1901595 biolink:NamedThing response to hesperadin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus. got7fsn_ti mah 2012-11-07T17:16:57Z biological_process owl:Class
GO:0044193 biolink:NamedThing host cell mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope. got7fsn_ti jl 2009-10-15T04:18:44Z cellular_component owl:Class
GO:0039661 biolink:NamedThing host organelle outer membrane The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell. got7fsn_ti bf 2013-08-25T10:44:43Z cellular_component owl:Class
GO:0034282 biolink:NamedThing ent-pimara-8(14),15-diene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate. got7fsn_ti ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming] activity|ent-pimaradiene synthase activity RHEA:25540|EC:4.2.3.30|MetaCyc:RXN-7788|KEGG_REACTION:R09121 molecular_function owl:Class
GO:0044654 biolink:NamedThing starch alpha-glucosidase activity Catalysis of the reaction: starch + H2O = alpha-D-glucose. got7fsn_ti jl 2012-07-23T02:08:10Z EC:3.2.1.- molecular_function owl:Class
GO:0090599 biolink:NamedThing alpha-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. got7fsn_ti tb 2014-08-22T14:33:31Z EC:3.2.1.20|Reactome:R-HSA-9036729|Reactome:R-HSA-9036727 molecular_function owl:Class
GO:0055096 biolink:NamedThing low-density lipoprotein particle mediated signaling A series of molecular signals mediated by the detection of low-density lipoprotein particle. got7fsn_ti low-density lipoprotein particle-mediated signaling|low-density lipoprotein particle mediated signal transduction|low-density lipoprotein mediated signalling biological_process owl:Class
GO:0055095 biolink:NamedThing lipoprotein particle mediated signaling A series of molecular signals mediated by the detection of a lipoprotein particle. got7fsn_ti lipoprotein mediated signalling|lipoprotein particle-mediated signaling|lipoprotein particle mediated signal transduction biological_process owl:Class
GO:0045181 biolink:NamedThing glutamate synthase activity, NAD(P)H as acceptor Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+. got7fsn_ti glutamate synthase activity, NADH or NADPH as acceptor molecular_function owl:Class
GO:0015930 biolink:NamedThing glutamate synthase activity Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. got7fsn_ti molecular_function owl:Class
GO:0140297 biolink:NamedThing DNA-binding transcription factor binding Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. got7fsn_ti repressing transcription factor binding|transcription activator binding|activating transcription factor binding https://github.com/geneontology/go-ontology/issues/19354 pg 2018-11-28T12:48:20Z GO:0001107|GO:0033613|GO:0070491 molecular_function owl:Class
GO:0048069 biolink:NamedThing eye pigmentation Establishment of a pattern of pigment in the eye of an organism. got7fsn_ti Wikipedia:Eye_color biological_process owl:Class
GO:0102225 biolink:NamedThing 4,4'-diaponeurosporene desaturase activity Catalysis of the reaction: 4,4'-diaponeurosporene + FAD + H+ <=> 4,4'-diapolycopene + FADH2. got7fsn_ti MetaCyc:RXN-12258|RHEA:31407 molecular_function owl:Class
GO:0034278 biolink:NamedThing stemar-13-ene synthase activity Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate. got7fsn_ti 9alpha-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming) activity EC:4.2.3.33|KEGG_REACTION:R09115|RHEA:25552|MetaCyc:RXN-4882 molecular_function owl:Class
GO:0000500 biolink:NamedThing RNA polymerase I upstream activating factor complex A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p. got7fsn_ti UAF|RNA polymerase I upstream activation factor complex cellular_component owl:Class
GO:0000120 biolink:NamedThing RNA polymerase I transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I. got7fsn_ti RNA polymerase I transcription factor complex cellular_component owl:Class
GO:0033916 biolink:NamedThing beta-agarase activity Catalysis of the hydrolysis of (1->4)-beta-D-galactosidic linkages in agarose, giving the tetramer as the predominant product. got7fsn_ti agarose 4-glycanohydrolase activity|AgaB|AgaA|agarose 3-glycanohydrolase activity|agarase activity EC:3.2.1.81 molecular_function owl:Class
GO:0032100 biolink:NamedThing positive regulation of appetite Any process that increases appetite. got7fsn_ti up regulation of appetite|activation of appetite|stimulation of appetite|up-regulation of appetite|positive regulation of hunger|appetite stimulation|upregulation of appetite biological_process owl:Class
GO:0032097 biolink:NamedThing positive regulation of response to food Any process that activates, maintains, or increases the rate of a response to a food stimulus. got7fsn_ti upregulation of response to food|up-regulation of response to food|stimulation of response to food|up regulation of response to food|activation of response to food biological_process owl:Class
GO:0006575 biolink:NamedThing cellular modified amino acid metabolic process The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents. got7fsn_ti cellular modified amino acid metabolism|cellular amino acid derivative metabolism|modified amino acid metabolism|modified amino acid metabolic process|amino acid derivative metabolic process|cellular amino acid derivative metabolic process biological_process owl:Class
GO:0007020 biolink:NamedThing microtubule nucleation The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). got7fsn_ti Wikipedia:Microtubule_nucleation biological_process owl:Class
GO:0019328 biolink:NamedThing anaerobic gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen. got7fsn_ti anaerobic gallate breakdown|gallate fermentation|anaerobic gallic acid catabolism|anaerobic gallic acid catabolic process|anaerobic gallate catabolism|anaerobic gallate degradation MetaCyc:P3-PWY biological_process owl:Class
GO:0019396 biolink:NamedThing gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). got7fsn_ti gallate degradation|gallate metabolism|gallate catabolism|gallate metabolic process|gallic acid catabolic process|gallic acid metabolic process|gallic acid metabolism|gallic acid catabolism|gallate breakdown https://github.com/geneontology/go-ontology/issues/20974 GO:0018918 UM-BBD_pathwayID:gal biological_process owl:Class
GO:0055118 biolink:NamedThing negative regulation of cardiac muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction. got7fsn_ti biological_process owl:Class
GO:0045988 biolink:NamedThing negative regulation of striated muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction. got7fsn_ti down regulation of striated muscle contraction|inhibition of striated muscle contraction|downregulation of striated muscle contraction|down-regulation of striated muscle contraction biological_process owl:Class
GO:0019420 biolink:NamedThing dissimilatory sulfate reduction The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide. got7fsn_ti dissimilatory sulphate reduction MetaCyc:DISSULFRED-PWY biological_process owl:Class
GO:0043255 biolink:NamedThing regulation of carbohydrate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates. got7fsn_ti regulation of carbohydrate biosynthesis|regulation of carbohydrate synthesis|regulation of carbohydrate anabolism|regulation of carbohydrate formation biological_process owl:Class
GO:0009889 biolink:NamedThing regulation of biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. got7fsn_ti regulation of anabolism|regulation of biosynthesis|regulation of synthesis|regulation of formation biological_process owl:Class
GO:0102498 biolink:NamedThing maltose glucosidase activity Catalysis of the reaction: H2O + maltose = 2 glucose. got7fsn_ti MetaCyc:RXN-15910 molecular_function owl:Class
GO:0102094 biolink:NamedThing S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a demethylmenaquinol <=> S-adenosyl-L-homocysteine + H+ + a menaquinol. got7fsn_ti RHEA:26466|EC:2.1.1.163|MetaCyc:RXN-11046 molecular_function owl:Class
GO:1901571 biolink:NamedThing fatty acid derivative transport The directed movement of a fatty acid derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti pr 2012-11-04T17:13:49Z biological_process owl:Class
GO:0021635 biolink:NamedThing trigeminal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. got7fsn_ti CN V maturation biological_process owl:Class
GO:1904363 biolink:NamedThing negative regulation of calcitonin secretion Any process that stops, prevents or reduces the frequency, rate or extent of calcitonin secretion. got7fsn_ti inhibition of calcitonin secretion|down-regulation of calcitonin secretion|down regulation of calcitonin secretion|downregulation of calcitonin secretion sl 2015-06-15T17:54:58Z biological_process owl:Class
GO:0046722 biolink:NamedThing lactic acid secretion The controlled release of lactic acid, 2-hydroxypropanoic acid, by a cell or a tissue. got7fsn_ti lactate secretion biological_process owl:Class
GO:0035879 biolink:NamedThing plasma membrane lactate transport The directed movement of lactate across a plasma membrane. got7fsn_ti lactate plasma membrane transport bf 2011-05-31T02:54:32Z biological_process owl:Class
GO:0043884 biolink:NamedThing CO-methylating acetyl-CoA synthase activity Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA. got7fsn_ti ACS|CO-methylating acetyl-coenzyme A synthase activity|acetyl-CoA:corrinoid protein O-acetyltransferase activity|acetyl-CoA synthase activity MetaCyc:ACETYLSYNCLTH-RXN|EC:2.3.1.169|RHEA:45212 molecular_function owl:Class
GO:0030196 biolink:NamedThing cyanide hydratase activity Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide. got7fsn_ti formamide dehydratase activity|formamide hydro-lyase activity|formamide hydro-lyase (cyanide-forming) EC:4.2.1.66|RHEA:21720|MetaCyc:CYANIDE-HYDRATASE-RXN|KEGG_REACTION:R01408 molecular_function owl:Class
GO:0047560 biolink:NamedThing 3-dehydrosphinganine reductase activity Catalysis of the reaction: NADP(+) + sphinganine = 3-dehydrosphinganine + H(+) + NADPH. got7fsn_ti D-3-dehydrosphinganine reductase activity|D-erythro-dihydrosphingosine:NADP+ 3-oxidoreductase activity|3-oxosphinganine:NADPH oxidoreductase activity|D-3-oxosphinganine reductase activity|3-oxosphinganine reductase activity|DSR activity|KTS reductase activity|3-ketosphinganine reductase activity|D-3-oxosphinganine:B-NADPH oxidoreductase activity RHEA:22640|EC:1.1.1.102|MetaCyc:3-DEHYDROSPHINGANINE-REDUCTASE-RXN|KEGG_REACTION:R02978|Reactome:R-HSA-428123 molecular_function owl:Class
GO:0070670 biolink:NamedThing response to interleukin-4 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. got7fsn_ti response to IL-4 mah 2009-05-29T10:01:46Z biological_process owl:Class
GO:0004721 biolink:NamedThing phosphoprotein phosphatase activity Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. got7fsn_ti protein phosphatase-2B activity|protein phosphatase-2C activity|protein phosphatase-2A activity|protein phosphatase activity|protein phosphatase-1 activity|phosphoprotein phosphohydrolase activity Reactome:R-HSA-170161|Reactome:R-HSA-174110|Reactome:R-HSA-174124|Reactome:R-HSA-69199|Reactome:R-HSA-170153|MetaCyc:3.1.3.16-RXN|Reactome:R-HSA-1363274|Reactome:R-HSA-2529015|Reactome:R-HSA-170158|Reactome:R-HSA-1363276|Reactome:R-HSA-112383|Reactome:R-HSA-113503|Reactome:R-HSA-9636684|Reactome:R-HSA-178178|Reactome:R-HSA-167072 molecular_function owl:Class
GO:0030668 biolink:NamedThing merozoite dense granule membrane The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites. got7fsn_ti cellular_component owl:Class
GO:0071614 biolink:NamedThing linoleic acid epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts linoleic acid to a cis-epoxyoctadecenoic acid. got7fsn_ti linoleic acid monooxygenase activity mah 2010-02-05T06:05:22Z molecular_function owl:Class
GO:0000324 biolink:NamedThing fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. got7fsn_ti vacuole, cell cycle-correlated morphology cellular_component owl:Class
GO:0000322 biolink:NamedThing storage vacuole A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules. got7fsn_ti cellular_component owl:Class
GO:0034678 biolink:NamedThing integrin alpha8-beta1 complex An integrin complex that comprises one alpha8 subunit and one beta1 subunit. got7fsn_ti alpha8-beta1 integrin complex|ITGA8-ITGB1 complex cellular_component owl:Class
GO:0016643 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. got7fsn_ti oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor EC:1.4.7.- molecular_function owl:Class
GO:0051092 biolink:NamedThing positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB. got7fsn_ti activation of NF-kappaB transcription factor|activation of NF-kappaB|NF-kappaB activation biological_process owl:Class
GO:0051091 biolink:NamedThing positive regulation of DNA-binding transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. got7fsn_ti activation of transcription factor activity|positive regulation of DNA binding transcription factor activity|upregulation of transcription factor activity|positive regulation of transcription factor activity|up regulation of transcription factor activity|stimulation of transcription factor activity|up-regulation of transcription factor activity|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of thyroid hormone receptor activity rph 2015-04-22T12:22:16Z GO:1904169 biological_process owl:Class
GO:0090292 biolink:NamedThing nuclear matrix anchoring at nuclear membrane The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane. got7fsn_ti nucleoskeleton anchoring at nuclear membrane tb 2010-02-22T03:05:13Z biological_process owl:Class
GO:0043578 biolink:NamedThing nuclear matrix organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane. got7fsn_ti nuclear matrix organisation|nuclear matrix organization and biogenesis|nucleoskeleton organization biological_process owl:Class
GO:0106320 biolink:NamedThing (R)-limonene 1,2-monooxygenase NADPH activity Catalysis of the reaction: (4R)-limonene + NADPH + H+ + O2 = NADP+ + H2O + (4R)-limonene-1,2-epoxide. got7fsn_ti hjd 2020-09-23T15:20:57Z EC:1.14.13.107|RHEA:26097 molecular_function owl:Class
GO:0018635 biolink:NamedThing (R)-limonene 1,2-monooxygenase activity Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide. got7fsn_ti (+)-limonene 1,2-monooxygenase activity|(R)-limonene,NAD(P)H:oxygen oxidoreductase activity|(+)-limonene,NAD(P)H:oxygen oxidoreductase activity EC:1.14.13.107|MetaCyc:RXN-9407|UM-BBD_reactionID:r0733|KEGG_REACTION:R09393|KEGG_REACTION:R06398 molecular_function owl:Class
GO:0071129 biolink:NamedThing alphaV-beta3 integrin-LPP3 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to lipid phosphate phosphohydrolase-3. got7fsn_ti ITGAV-ITGB3-PPAP2B complex mah 2009-11-13T02:25:17Z cellular_component owl:Class
GO:0032208 biolink:NamedThing negative regulation of telomere maintenance via recombination Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. got7fsn_ti downregulation of telomere maintenance via recombination|inhibition of telomere maintenance via recombination|down regulation of telomere maintenance via recombination|down-regulation of telomere maintenance via recombination biological_process owl:Class
GO:0048239 biolink:NamedThing negative regulation of DNA recombination at telomere Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere. got7fsn_ti down regulation of telomeric recombination at telomere|negative regulation of telomeric recombination at telomere|down-regulation of telomeric recombination at telomere|suppression of telomeric recombination at telomere|inhibition of telomeric recombination at telomere|downregulation of telomeric recombination at telomere biological_process owl:Class
GO:0006928 biolink:NamedThing movement of cell or subcellular component The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. got7fsn_ti cellular component movement|cellular component motion|cell movement Note that in GO cellular components include whole cells (cell is_a cellular component). biological_process owl:Class
GO:0036169 biolink:NamedThing 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2. got7fsn_ti bf 2012-03-27T04:47:47Z Reactome:R-HSA-2162195 molecular_function owl:Class
GO:0010223 biolink:NamedThing secondary shoot formation The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs. got7fsn_ti auxiliary shoot formation|axillary shoot formation|axillary shoot system formation|shoot branching biological_process owl:Class
GO:0001763 biolink:NamedThing morphogenesis of a branching structure The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes. got7fsn_ti branching morphogenesis biological_process owl:Class
GO:0004309 biolink:NamedThing exopolyphosphatase activity Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate. got7fsn_ti exopolypase activity|metaphosphatase activity|polyphosphate phosphohydrolase activity|Gra-Pase activity|acid phosphoanhydride phosphohydrolase activity RHEA:21528|MetaCyc:EXOPOLYPHOSPHATASE-RXN|EC:3.6.1.11 molecular_function owl:Class
GO:0102628 biolink:NamedThing costunolide 3beta-hydroxylase activity Catalysis of the reaction: costunolide + NADPH + O2 + H+ <=> 3beta-hydroxycostunolide + NADP + H2O. got7fsn_ti MetaCyc:RXN-15533 molecular_function owl:Class
GO:0000758 biolink:NamedThing agglutination involved in conjugation with mutual genetic exchange The aggregation or adhesion of compatible mating types via complementary cell-cell interactions during conjugation without cellular fusion of a unicellular organism. got7fsn_ti agglutination involved in conjugation without cellular fusion|sexual flocculation biological_process owl:Class
GO:0004477 biolink:NamedThing methenyltetrahydrofolate cyclohydrolase activity Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. got7fsn_ti 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)|citrovorum factor cyclodehydrase activity|5,10-methenyl-THF cyclohydrolase activity|formyl-methenyl-methylenetetrahydrofolate synthetase (combined) EC:3.5.4.9|Reactome:R-HSA-6801328|RHEA:23700|Reactome:R-HSA-200661|MetaCyc:METHENYLTHFCYCLOHYDRO-RXN|Reactome:R-HSA-200740 molecular_function owl:Class
GO:0052154 biolink:NamedThing modulation by symbiont of host B-cell mediated immune response Any process in which a symbiont modulates the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction|regulation by organism of host B-cell mediated immune response GO:0052293 biological_process owl:Class
GO:0052553 biolink:NamedThing modulation by symbiont of host immune response Any process in which a symbiont modulates the frequency, rate or extent of the immune response of the host organism; the immune response is any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of immune response of other organism involved in symbiotic interaction GO:0052552 biological_process owl:Class
GO:0015954 biolink:NamedThing pyrimidine ribonucleotide interconversion The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide. got7fsn_ti biological_process owl:Class
GO:0009218 biolink:NamedThing pyrimidine ribonucleotide metabolic process The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti pyrimidine ribonucleotide metabolism biological_process owl:Class
GO:0046190 biolink:NamedThing aerobic phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. got7fsn_ti aerobic phenol-containing compound formation|aerobic phenol-containing compound anabolism|aerobic phenol-containing compound synthesis|aerobic phenol-containing compound biosynthesis biological_process owl:Class
GO:0046189 biolink:NamedThing phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. got7fsn_ti phenol-containing compound formation|phenol-containing compound biosynthesis|phenol-containing compound anabolism|phenol-containing compound synthesis biological_process owl:Class
GO:0060304 biolink:NamedThing regulation of phosphatidylinositol dephosphorylation Any process that modulates the frequency, rate or extent of the chemical reaction involving the removal of one or more phosphate groups from a phosphatidylinositol. got7fsn_ti regulation of phosphoinositide dephosphorylation biological_process owl:Class
GO:0060255 biolink:NamedThing regulation of macromolecule metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biological_process owl:Class
GO:0019777 biolink:NamedThing Atg12 transferase activity Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages. got7fsn_ti Atg12 conjugating enzyme activity|APG12 conjugating enzyme activity|APG12 ligase activity|Atg12 ligase activity Reactome:R-HSA-5681999 molecular_function owl:Class
GO:0097451 biolink:NamedThing glial limiting end-foot Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans. got7fsn_ti glial limiting endfoot pr 2012-12-17T13:36:34Z NIF_Subcellular:sao181458425 cellular_component owl:Class
GO:0097450 biolink:NamedThing astrocyte end-foot Terminal process of astrocyte abutting non-neuronal surfaces in the brain. got7fsn_ti astrocyte endfoot pr 2012-12-17T13:33:55Z NIF_Subcellular:sao388182739 cellular_component owl:Class
GO:0098777 biolink:NamedThing protein secretion by the type VIII secretion system Protein secretion through the outer membrane via the mechanism used for the secretion of curli subunits. got7fsn_ti T8SS This term is defined so as to leave open the possibility that things other than curli subunits are secreted via same secretory system as that used by curli subunits. biological_process owl:Class
GO:0102681 biolink:NamedThing isoamylase (maltodextrin-releasing) activity Catalysis of the reaction: n H2O + a glycogen <=> n a maltodextrin. got7fsn_ti MetaCyc:RXN-4301 molecular_function owl:Class
GO:0045469 biolink:NamedThing negative regulation of R8 cell spacing in compound eye Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye. got7fsn_ti inhibition of R8 spacing|downregulation of R8 spacing|down regulation of R8 spacing|down-regulation of R8 spacing biological_process owl:Class
GO:0045468 biolink:NamedThing regulation of R8 cell spacing in compound eye Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc. got7fsn_ti R8 cell spacing in compound eye|regulation of R8 spacing biological_process owl:Class
GO:0060658 biolink:NamedThing nipple morphogenesis The process in which the nipple is generated and organized. got7fsn_ti dph 2009-05-29T10:45:44Z biological_process owl:Class
GO:0090605 biolink:NamedThing submerged biofilm formation A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription. got7fsn_ti solid substrate biofilm formation tb 2014-09-16T14:44:46Z biological_process owl:Class
GO:1990349 biolink:NamedThing gap junction-mediated intercellular transport The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells. got7fsn_ti hjd 2014-03-25T18:05:44Z biological_process owl:Class
GO:0010496 biolink:NamedThing intercellular transport The movement of substances between cells. got7fsn_ti single-organism intercellular transport|single organism intercellular transport jl 2013-12-19T13:24:56Z GO:1902585 biological_process owl:Class
GO:0002771 biolink:NamedThing inhibitory killer cell immunoglobulin-like receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response. got7fsn_ti inhibitory killer cell immunoglobulin-like receptor signalling pathway|KIR signaling pathway|killer cell inhibitory receptor signaling pathway biological_process owl:Class
GO:0051361 biolink:NamedThing peptide cross-linking via L-lysine 5-imidazolinone glycine The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. got7fsn_ti biosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via L-lysine 5-imidazolinone glycine See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. RESID:AA0381 biological_process owl:Class
GO:0060652 biolink:NamedThing mammary gland cord morphogenesis The process in which anatomical structures of the mammary gland cord are generated and organized. Mammary gland cords form when the mammary gland bud invades the mammary fat. got7fsn_ti mammary gland sprout morphogenesis dph 2009-05-29T09:06:56Z biological_process owl:Class
GO:0097324 biolink:NamedThing melanocyte migration The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. got7fsn_ti pr 2012-06-08T10:08:18Z biological_process owl:Class
GO:0140587 biolink:NamedThing chromatin loop anchoring activity Bridging together two DNA loop anchors together, maintaining a chromatin loop. got7fsn_ti DNA loop binding|chromosomal loop binding https://github.com/geneontology/go-ontology/issues/20204 pg 2021-02-04T14:53:13Z molecular_function owl:Class
GO:0090148 biolink:NamedThing membrane fission A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. got7fsn_ti membrane scission tb 2009-12-08T03:06:36Z biological_process owl:Class
GO:0090106 biolink:NamedThing pancreatic E cell fate commitment The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell. got7fsn_ti tb 2009-11-18T11:51:41Z biological_process owl:Class
GO:0051077 biolink:NamedThing secondary cell septum Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum. got7fsn_ti secondary septum cellular_component owl:Class
GO:0000935 biolink:NamedThing division septum A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments. got7fsn_ti septum surface|cell septum surface|complete septum|divison septum https://github.com/geneontology/go-ontology/issues/19434 GO:0043187 cellular_component owl:Class
GO:0090377 biolink:NamedThing seed trichome initiation The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis. got7fsn_ti seed trichome fate commitment These processes continue up to 3 days post-anthesis (DPA) in Gossypium spp. tb 2010-09-15T02:13:59Z biological_process owl:Class
GO:0019129 biolink:NamedThing peptidyl-leucine racemization The racemization of peptidyl-leucine. got7fsn_ti GO:0018093|GO:0018375 RESID:AA0197 biological_process owl:Class
GO:0032394 biolink:NamedThing MHC class Ib receptor activity Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. got7fsn_ti T cell receptor activity|alpha-beta T cell receptor activity|gamma-delta T cell receptor activity Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves. molecular_function owl:Class
GO:1990627 biolink:NamedThing mitochondrial inner membrane fusion The membrane organization process that joins two mitochondrial inner membranes to form a single membrane. got7fsn_ti mitochondrion inner membrane fusion vw 2015-02-02T11:37:56Z biological_process owl:Class
GO:0007007 biolink:NamedThing inner mitochondrial membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane. got7fsn_ti mitochondrial inner membrane organization|inner mitochondrial membrane organization and biogenesis|inner mitochondrial membrane organisation See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. biological_process owl:Class
GO:0005791 biolink:NamedThing rough endoplasmic reticulum The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae. got7fsn_ti rough ER|RER NIF_Subcellular:sao1881364067|Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum cellular_component owl:Class
GO:0005783 biolink:NamedThing endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). got7fsn_ti ER Wikipedia:Endoplasmic_reticulum|NIF_Subcellular:sao1036339110 cellular_component owl:Class
GO:0008273 biolink:NamedThing calcium, potassium:sodium antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). got7fsn_ti potassium-dependent sodium/calcium exchanger Reactome:R-HSA-2514891|Reactome:R-HSA-5626316|Reactome:R-HSA-5626270|Reactome:R-HSA-5626356|Reactome:R-HSA-5625841|Reactome:R-HSA-425678 molecular_function owl:Class
GO:0022821 biolink:NamedThing potassium ion antiporter activity Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. got7fsn_ti molecular_function owl:Class
GO:1990459 biolink:NamedThing transferrin receptor binding Binding to a transferrin receptor. got7fsn_ti tb 2014-08-18T20:14:24Z molecular_function owl:Class
GO:0045994 biolink:NamedThing positive regulation of translational initiation by iron Any process involving iron that activates or increases the rate of translational initiation. got7fsn_ti stimulation of translational initiation by iron|upregulation of translational initiation by iron|activation of translational initiation by iron|up regulation of translational initiation by iron|up-regulation of translational initiation by iron biological_process owl:Class
GO:0004749 biolink:NamedThing ribose phosphate diphosphokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+). got7fsn_ti ribose-phosphate pyrophosphokinase activity|ribophosphate pyrophosphokinase activity|ribose-5-phosphate pyrophosphokinase activity|pyrophosphoribosylphosphate synthetase activity|phosphoribosyl-diphosphate synthetase activity|PP-ribose P synthetase activity|ribose-phosphate diphosphokinase activity|phosphoribosyl diphosphate synthetase activity|PRPP synthetase activity|phosphoribosylpyrophosphate synthase activity|phosphoribosylpyrophosphate synthetase activity|ATP:D-ribose-5-phosphate diphosphotransferase activity|phosphoribosyl pyrophosphate synthetase activity|5-phosphoribose pyrophosphorylase activity|5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity|PPRibP synthetase activity|5-phosphoribosyl-1-pyrophosphate synthetase activity RHEA:15609|EC:2.7.6.1|Reactome:R-HSA-73580|KEGG_REACTION:R01049|MetaCyc:PRPPSYN-RXN|MetaCyc:PWY0-662|Reactome:R-HSA-111215 molecular_function owl:Class
GO:0016778 biolink:NamedThing diphosphotransferase activity Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). got7fsn_ti EC:2.7.6.- molecular_function owl:Class
GO:0032933 biolink:NamedThing SREBP signaling pathway A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription. got7fsn_ti sterol depletion response, SREBP target gene transcriptional activation|stimulation of sterol regulatory element binding protein target gene transcription|upregulation of sterol regulatory element binding protein target gene transcription|positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response|ER-nuclear sterol response pathway|positive regulation of sterol regulatory element binding protein target gene transcription|up-regulation of sterol regulatory element binding protein target gene transcription|SREBP target gene transcriptional activation|sterol regulatory element binding protein target gene transcriptional activation|positive regulation of transcription via sterol regulatory element binding|SREBP signalling|up regulation of sterol regulatory element binding protein target gene transcription|endoplasmic reticulum to nucleus sterol response pathway|SREBP-mediated signalling pathway|ER to nucleus sterol response pathway|endoplasmic reticulum-nuclear sterol response pathway|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway|sterol response element binding protein signaling pathway|activation of sterol regulatory element binding protein target gene transcription|SREBP-mediated signaling pathway GO:0035104|GO:0030967|GO:0006994 biological_process owl:Class
GO:0006984 biolink:NamedThing ER-nucleus signaling pathway Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation. got7fsn_ti ER-nuclear signaling pathway|endoplasmic reticulum to nucleus signaling pathway|ER to nucleus signalling pathway|endoplasmic reticulum-nuclear signaling pathway|ER to nucleus signaling pathway|ER-nuclear signalling pathway biological_process owl:Class
GO:0098960 biolink:NamedThing postsynaptic neurotransmitter receptor activity Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission. got7fsn_ti neurotransmitter receptor activity involved in chemical synaptic transmission molecular_function owl:Class
GO:0035623 biolink:NamedThing renal glucose absorption A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. got7fsn_ti glucose reabsorption|nephron glucose absorption bf 2010-12-08T04:14:23Z biological_process owl:Class
GO:1904659 biolink:NamedThing glucose transmembrane transport The process in which glucose is transported across a membrane. got7fsn_ti glucose transport vw 2015-09-04T17:20:16Z GO:0015758 biological_process owl:Class
GO:0022610 biolink:NamedThing biological adhesion The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions. got7fsn_ti biological_process owl:Class
GO:0047518 biolink:NamedThing 1-methyladenosine nucleosidase activity Catalysis of the reaction: 1-methyladenosine + H(2)O = 1-methyladenine + ribofuranose. got7fsn_ti 1-methyladenosine ribohydrolase activity|1-methyladenosine hydrolase activity MetaCyc:1-METHYLADENOSINE-NUCLEOSIDASE-RXN|KEGG_REACTION:R03885|RHEA:12865|EC:3.2.2.13 molecular_function owl:Class
GO:0039023 biolink:NamedThing pronephric duct morphogenesis The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney. got7fsn_ti bf 2010-07-02T10:18:09Z biological_process owl:Class
GO:0072178 biolink:NamedThing nephric duct morphogenesis The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. got7fsn_ti mah 2010-02-26T02:35:29Z biological_process owl:Class
GO:0007174 biolink:NamedThing epidermal growth factor catabolic process The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor. got7fsn_ti EGF catabolism|epidermal growth factor breakdown|EGF breakdown|epidermal growth factor ligand processing|epidermal growth factor catabolism|EGF receptor ligand processing|receptor-mediated EGF processing|intracellular EGF processing This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'. biological_process owl:Class
GO:0042059 biolink:NamedThing negative regulation of epidermal growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. got7fsn_ti inhibition of epidermal growth factor receptor signaling pathway|down-regulation of epidermal growth factor receptor signaling pathway|down regulation of epidermal growth factor receptor signaling pathway|negative regulation of EGF receptor signaling pathway|downregulation of epidermal growth factor receptor signaling pathway|negative regulation of EGFR signaling pathway|negative regulation of EGF receptor signalling pathway biological_process owl:Class
GO:0016163 biolink:NamedThing nitrogenase activity Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate. got7fsn_ti reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity|vanadium-iron nitrogenase activity|iron-iron nitrogenase activity|molybdenum-iron nitrogenase activity UM-BBD_enzymeID:e0395|RHEA:21448|MetaCyc:NITROGENASE-RXN|EC:1.18.6.1 molecular_function owl:Class
GO:0016732 biolink:NamedThing oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen. got7fsn_ti EC:1.18.6.- molecular_function owl:Class
GO:0009747 biolink:NamedThing hexokinase-dependent signaling A series of molecular signals mediated by hexose and dependent on the detection of hexokinase. got7fsn_ti hexokinase-dependent signalling biological_process owl:Class
GO:0050189 biolink:NamedThing phosphoenolpyruvate phosphatase activity Catalysis of the reaction: H(2)O + phosphoenolpyruvate = phosphate + pyruvate. got7fsn_ti PEP phosphatase activity|phosphoenolpyruvate phosphohydrolase activity EC:3.1.3.60|KEGG_REACTION:R00208|MetaCyc:PHOSPHOENOLPYRUVATE-PHOSPHATASE-RXN|RHEA:19997 molecular_function owl:Class
GO:0018344 biolink:NamedThing protein geranylgeranylation The covalent attachment of a geranylgeranyl group to a protein. got7fsn_ti C-terminal protein geranylgeranylation|protein amino acid geranylgeranylation GO:0018348 biological_process owl:Class
GO:0018342 biolink:NamedThing protein prenylation The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added. got7fsn_ti protein amino acid prenylation|C-terminal protein prenylation GO:0018346 biological_process owl:Class
GO:0047665 biolink:NamedThing aminolevulinate transaminase activity Catalysis of the reaction: 5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine. got7fsn_ti aminolevulinate aminotransferase activity|dioxovalerate transaminase activity|gamma,delta-dioxovaleric acid transaminase activity|5-aminolevulinate:pyruvate aminotransferase activity|alanine:4,5-dioxovalerate aminotransferase activity|gamma,delta-dioxovalerate aminotransferase activity|L-alanine:4,5-dioxovaleric acid transaminase activity|4,5-dioxovalerate aminotransferase activity|L-alanine-4,5-dioxovalerate aminotransferase activity|4,5-dioxovaleric transaminase activity|4,5-dioxovaleric acid transaminase activity|DOVA transaminase activity|5-aminolevulinic acid transaminase activity|alanine-gamma,delta-dioxovalerate aminotransferase activity|4,5-dioxovaleric acid aminotransferase activity|alanine-dioxovalerate aminotransferase activity|aminolevulinic acid transaminase activity|L-alanine:dioxovalerate transaminase activity KEGG_REACTION:R02271|MetaCyc:AMINOLEVULINATE-AMINOTRANSFERASE-RXN|EC:2.6.1.43|RHEA:12480 molecular_function owl:Class
GO:0043949 biolink:NamedThing regulation of cAMP-mediated signaling Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. got7fsn_ti regulation of cAMP-mediated signalling biological_process owl:Class
GO:0070208 biolink:NamedThing protein heterotrimerization The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical. got7fsn_ti protein heterotrimer formation|protein heterotrimer biosynthetic process|protein heterotrimer assembly|protein heterotrimer biosynthesis biological_process owl:Class
GO:0070206 biolink:NamedThing protein trimerization The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits. got7fsn_ti protein trimer assembly|protein trimer formation|protein trimer biosynthesis|protein trimer biosynthetic process biological_process owl:Class
GO:0009951 biolink:NamedThing polarity specification of dorsal/ventral axis Any process resulting in the establishment of polarity along the dorsal/ventral axis. got7fsn_ti polarity specification of dorsoventral axis|polarity specification of dorsal-ventral axis biological_process owl:Class
GO:0065001 biolink:NamedThing specification of axis polarity The pattern specification process in which the polarity of a body or organ axis is established and maintained. got7fsn_ti biological_process owl:Class
GO:0060707 biolink:NamedThing trophoblast giant cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a trophoblast giant cell of the placenta. Trophoblast giant cells are the cell of the placenta that line the maternal decidua. got7fsn_ti dph 2009-06-09T10:32:12Z biological_process owl:Class
GO:0060706 biolink:NamedThing cell differentiation involved in embryonic placenta development The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta. got7fsn_ti dph 2009-06-09T10:26:42Z biological_process owl:Class
BFO:0000015 biolink:NamedThing got7fsn_ti owl:Class
GO:0055073 biolink:NamedThing cadmium ion homeostasis Any process involved in the maintenance of an internal steady state of cadmium ions within an organism or cell. got7fsn_ti cadmium homeostasis biological_process owl:Class
GO:0072507 biolink:NamedThing divalent inorganic cation homeostasis Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell. got7fsn_ti Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'trivalent inorganic cation homeostasis' ; GO:0072508'). mah 2010-12-16T03:22:48Z biological_process owl:Class
GO:0003329 biolink:NamedThing pancreatic PP cell fate commitment The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. got7fsn_ti dph 2009-11-02T08:35:13Z biological_process owl:Class
GO:0004989 biolink:NamedThing octopamine receptor activity Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist. got7fsn_ti molecular_function owl:Class
GO:0008227 biolink:NamedThing G protein-coupled amine receptor activity Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti biogenic amine receptor|amine receptor activity, G-protein coupled|G-protein coupled amine receptor activity molecular_function owl:Class
GO:0048675 biolink:NamedThing axon extension Long distance growth of a single axon process involved in cellular development. got7fsn_ti axon extension involved in development GO:0048676 biological_process owl:Class
GO:0060539 biolink:NamedThing diaphragm development The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs. got7fsn_ti dph 2009-04-10T08:44:56Z biological_process owl:Class
GO:0060538 biolink:NamedThing skeletal muscle organ development The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue. got7fsn_ti dph 2009-04-10T08:25:12Z biological_process owl:Class
GO:0044563 biolink:NamedThing envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism. got7fsn_ti voltage-dependence of activation shift (to the left) jl 2012-04-05T04:06:29Z biological_process owl:Class
GO:0097314 biolink:NamedThing apoptosome assembly The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process. got7fsn_ti apoptosome formation pr 2012-05-28T03:39:49Z biological_process owl:Class
GO:0008685 biolink:NamedThing 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP. got7fsn_ti 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)|MECDP-synthase activity|2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)|MECP synthase activity MetaCyc:RXN0-302|EC:4.6.1.12|RHEA:23864|KEGG_REACTION:R05637 molecular_function owl:Class
GO:0044013 biolink:NamedThing H2B histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine. got7fsn_ti H2B histone lysine N-acetyltransferase activity molecular_function owl:Class
GO:0035721 biolink:NamedThing intraciliary retrograde transport The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins. got7fsn_ti intraflagellar retrograde transport Note that we deem cilium and microtubule-based flagellum to be equivalent. bf 2011-03-07T11:25:32Z biological_process owl:Class
GO:0060026 biolink:NamedThing convergent extension The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis. got7fsn_ti Wikipedia:Convergent_extension biological_process owl:Class
GO:0032135 biolink:NamedThing DNA insertion or deletion binding Binding to a double-stranded DNA region containing an insertion or a deletion. got7fsn_ti insertion binding|DNA insertion binding molecular_function owl:Class
GO:0008296 biolink:NamedThing 3'-5'-exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. got7fsn_ti 3'-5' exodeoxyribonuclease activity Reactome:R-HSA-9023943 molecular_function owl:Class
GO:0033711 biolink:NamedThing 4-phosphoerythronate dehydrogenase activity Catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH. got7fsn_ti erythronate-4-phosphate dehydrogenase activity|PdxB 4PE dehydrogenase activity|4PE dehydrogenase activity|4-phospho-D-erythronate:NAD+ 2-oxidoreductase activity|PdxB|4-O-phosphoerythronate dehydrogenase activity RHEA:18829|EC:1.1.1.290|KEGG_REACTION:R04210|MetaCyc:ERYTHRON4PDEHYDROG-RXN molecular_function owl:Class
GO:0045617 biolink:NamedThing negative regulation of keratinocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation. got7fsn_ti down-regulation of keratinocyte differentiation|down regulation of keratinocyte differentiation|inhibition of keratinocyte differentiation|downregulation of keratinocyte differentiation biological_process owl:Class
GO:0045616 biolink:NamedThing regulation of keratinocyte differentiation Any process that modulates the frequency, rate or extent of keratinocyte differentiation. got7fsn_ti biological_process owl:Class
GO:0090553 biolink:NamedThing unicellular trichome tip A cell projection part that is the apical most portion of a unicellular trichome apex. got7fsn_ti tb 2013-04-25T11:56:56Z cellular_component owl:Class
GO:0007179 biolink:NamedThing transforming growth factor beta receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti TGFbeta receptor signalling pathway|TGF-beta receptor signalling pathway|TGFbeta receptor signaling pathway|TGF-beta receptor signaling pathway|transforming growth factor beta receptor signalling pathway biological_process owl:Class
GO:0007178 biolink:NamedThing transmembrane receptor protein serine/threonine kinase signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti transmembrane receptor protein serine/threonine kinase signalling pathway biological_process owl:Class
GO:0033165 biolink:NamedThing interphotoreceptor matrix A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance. got7fsn_ti cellular_component owl:Class
GO:0044657 biolink:NamedThing pore formation in membrane of other organism during symbiotic interaction The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction. got7fsn_ti jl 2012-08-01T13:12:10Z biological_process owl:Class
GO:0035915 biolink:NamedThing pore formation in membrane of other organism The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism. got7fsn_ti pore complex assembly in other organism|pore biosynthesis in other organism|pore formation in other organism|pore-forming toxin activity|pore complex biogenesis in other organism bf 2011-07-01T11:45:01Z biological_process owl:Class
GO:0007418 biolink:NamedThing ventral midline development The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate. got7fsn_ti biological_process owl:Class
GO:0061395 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. got7fsn_ti dph 2011-12-14T08:53:20Z biological_process owl:Class
GO:0034607 biolink:NamedThing turning behavior involved in mating The sharp ventral turn performed by the male as he approaches either the hermaphrodite head or tail, whilst trying to locate his partner's vulva. Turning occurs via a sharp ventral coil of the male's tail. got7fsn_ti turning behavior during mating biological_process owl:Class
GO:0060179 biolink:NamedThing male mating behavior The specific behavior of a male organism that is associated with reproduction. got7fsn_ti biological_process owl:Class
GO:0044315 biolink:NamedThing protein secretion by the type VII secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system. got7fsn_ti jl 2010-06-02T11:57:05Z biological_process owl:Class
GO:0034394 biolink:NamedThing protein localization to cell surface A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. got7fsn_ti protein localisation at cell surface|protein localization at cell surface biological_process owl:Class
GO:0043052 biolink:NamedThing thermotaxis The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature. got7fsn_ti taxis in response to temperature stimulus Wikipedia:Thermotaxis biological_process owl:Class
GO:0019287 biolink:NamedThing isopentenyl diphosphate biosynthetic process, mevalonate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates. got7fsn_ti isopentenyl diphosphate biosynthetic process via mevalonate|isopentenyl diphosphate anabolism, mevalonate pathway|isopentenyl diphosphate formation, mevalonate pathway|acetate-mevalonate pathway|Ac-MVA pathway|isopentenyl diphosphate synthesis, mevalonate pathway biological_process owl:Class
GO:0009240 biolink:NamedThing isopentenyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids. got7fsn_ti IPP biosynthesis|isopentenyl diphosphate anabolism|isopentenyl diphosphate synthesis|IPP biosynthetic process|isopentenyl pyrophosphate biosynthesis|isopentenyl diphosphate formation|isopentenyl diphosphate biosynthesis|isopentenyl pyrophosphate biosynthetic process biological_process owl:Class
GO:0009111 biolink:NamedThing vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti vitamin degradation|vitamin breakdown|vitamin catabolism biological_process owl:Class
GO:0038174 biolink:NamedThing interleukin-17A receptor activity Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti bf 2012-06-12T11:01:25Z molecular_function owl:Class
GO:0030368 biolink:NamedThing interleukin-17 receptor activity Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-17 receptor activity|IL-17R Wikipedia:Interleukin-17_receptor molecular_function owl:Class
GO:0019122 biolink:NamedThing peptidyl-D-alanine racemization The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine. got7fsn_ti alanine racemization See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'. RESID:AA0191 biological_process owl:Class
GO:0050670 biolink:NamedThing regulation of lymphocyte proliferation Any process that modulates the frequency, rate or extent of lymphocyte proliferation. got7fsn_ti biological_process owl:Class
GO:0033484 biolink:NamedThing nitric oxide homeostasis A homeostatic process involved in the maintenance of an internal steady state of nitric oxide within an organism or cell. got7fsn_ti NO homeostasis biological_process owl:Class
GO:0033483 biolink:NamedThing gas homeostasis A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0034293 biolink:NamedThing sexual sporulation The formation of spores derived from the products of meiosis. got7fsn_ti meiotic sporulation|meiotic spore formation|sexual spore formation biological_process owl:Class
GO:0043934 biolink:NamedThing sporulation The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. got7fsn_ti Wikipedia:Spore biological_process owl:Class
GO:0034588 biolink:NamedThing piRNA catabolic process The chemical reactions and pathways resulting in the breakdown of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. got7fsn_ti piRNA breakdown|piRNA degradation|Piwi-associated RNA catabolic process|piRNA catabolism biological_process owl:Class
GO:0034661 biolink:NamedThing ncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of non-coding RNA transcripts (ncRNAs). Includes the breakdown of cryptic unstable transcripts (CUTs). got7fsn_ti ncRNA degradation|ncRNA breakdown|ncRNA catabolism biological_process owl:Class
GO:0034492 biolink:NamedThing hydrogenosome lumen The volume enclosed by the hydrogenosome membrane. got7fsn_ti cellular_component owl:Class
GO:0021552 biolink:NamedThing midbrain-hindbrain boundary structural organization The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. got7fsn_ti MHB structural organization|isthmus structural organization|midbrain-hindbrain boundary structural organisation biological_process owl:Class
GO:0007594 biolink:NamedThing puparial adhesion The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation. got7fsn_ti puparial glue biological_process owl:Class
GO:0022609 biolink:NamedThing multicellular organism adhesion to substrate The attachment of a multicellular organism to a surface or material. got7fsn_ti biological_process owl:Class
GO:1990474 biolink:NamedThing synaptic vesicle, readily releasable pool A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton. got7fsn_ti readily releasable pool of synaptic vesicles|RRP pr 2014-09-02T09:02:41Z cellular_component owl:Class
GO:0031804 biolink:NamedThing type 7 metabotropic glutamate receptor binding Binding to a type 7 metabotropic glutamate receptor. got7fsn_ti type 7 metabotropic glutamate receptor ligand molecular_function owl:Class
GO:0060012 biolink:NamedThing synaptic transmission, glycinergic The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. got7fsn_ti glycinergic synaptic transmission biological_process owl:Class
GO:0018071 biolink:NamedThing NAD(P)-cysteine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine. got7fsn_ti molecular_function owl:Class
GO:0061566 biolink:NamedThing CMP phosphorylation The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP. got7fsn_ti dph 2013-08-01T12:52:39Z biological_process owl:Class
GO:0017182 biolink:NamedThing peptidyl-diphthamide metabolic process The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue. got7fsn_ti peptidyl-diphthamide metabolism biological_process owl:Class
GO:0050851 biolink:NamedThing antigen receptor-mediated signaling pathway A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell. got7fsn_ti antigen receptor-mediated signalling pathway biological_process owl:Class
GO:0002429 biolink:NamedThing immune response-activating cell surface receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response. got7fsn_ti immune response-activating cell surface receptor signalling pathway|activation of immune response by cell surface receptor signaling pathway biological_process owl:Class
GO:0106101 biolink:NamedThing ER-dependent peroxisome localization A process in which a protein is transported to, or maintained at, a location in a peroxisome via the endoplasmic reticulum. got7fsn_ti hjd 2018-02-15T17:54:20Z biological_process owl:Class
GO:0072662 biolink:NamedThing protein localization to peroxisome A process in which a protein is transported to, or maintained at, a location in a peroxisome. got7fsn_ti protein localisation to peroxisome mah 2011-02-14T02:50:04Z biological_process owl:Class
GO:0090120 biolink:NamedThing lysosome to ER cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum. got7fsn_ti lysosome to endoplasmic reticulum cholesterol transport tb 2009-12-07T12:22:12Z biological_process owl:Class
GO:0090119 biolink:NamedThing vesicle-mediated cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles. got7fsn_ti tb 2009-12-07T12:14:37Z biological_process owl:Class
GO:0106175 biolink:NamedThing phagolysosome vesicle membrane The lipid bylayer surrounding a phagolysosome. got7fsn_ti hjd 2019-02-11T19:12:53Z cellular_component owl:Class
GO:0007313 biolink:NamedThing maternal specification of dorsal/ventral axis, oocyte, soma encoded Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster. got7fsn_ti maternal specification of dorsoventral axis, oocyte, soma encoded|maternal determination of dorsal/ventral axis, oocyte, soma encoded|maternal specification of dorsal-ventral axis, oocyte, soma encoded GO:0048125 biological_process owl:Class
GO:0009826 biolink:NamedThing unidimensional cell growth The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. got7fsn_ti cell elongation|polar cell growth|polarized cell growth|cell growth along one axis|cell growth in one dimension|cell morphogenesis by unidimensional growth Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children. biological_process owl:Class
GO:0102375 biolink:NamedThing 11-oxo-beta-amyrin 30-oxidase activity Catalysis of the reaction: 11-oxo-beta-amyrin + 3 NADPH + 3 O2 + 2 H+ <=> glycyrrhetinic acid + 3 NADP + 4 H2O. got7fsn_ti RHEA:35499|EC:1.14.14.115|MetaCyc:RXN-13506 molecular_function owl:Class
GO:0098535 biolink:NamedThing de novo centriole assembly involved in multi-ciliated epithelial cell differentiation Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation. got7fsn_ti de novo centriole assembly|centriole amplification|deuterosome pathway|de novo centriole assembly via deuterosome|deuterosome-mediated centriole biogenesis|deuterosomal basal body biogenesis|multiciliation|multiciliogenesis In most eukaryotic cells, 'centriole' (GO:0005814) and 'ciliary basal body' (GO:0036064) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. dos 2013-10-22T16:03:13Z biological_process owl:Class
GO:0097742 biolink:NamedThing de novo centriole assembly Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects. got7fsn_ti de novo basal body biogenesis|de novo basal body generation|multiciliogenesis|acentriolar basal body biogenesis|de novo basal body assembly|de novo basal body amplification|de novo centriole amplification|de novo ciliary basal body assembly|multiciliation pr 2016-10-19T15:13:50Z biological_process owl:Class
GO:0048366 biolink:NamedThing leaf development The process whose specific outcome is the progression of the leaf over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0048827 biolink:NamedThing phyllome development The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants. got7fsn_ti biological_process owl:Class
GO:0000458 biolink:NamedThing endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. got7fsn_ti biological_process owl:Class
GO:0000449 biolink:NamedThing endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. got7fsn_ti biological_process owl:Class
GO:0006488 biolink:NamedThing dolichol-linked oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P. got7fsn_ti N-linked glycan precursor biosynthesis|dolichol-linked oligosaccharide synthesis|dolichol-linked oligosaccharide formation|dolichol-linked oligosaccharide biosynthesis|dolichol-linked oligosaccharide anabolism|N-linked glycan precursor biosynthetic process|oligosaccharide-PP-dolichol assembly biological_process owl:Class
GO:0006490 biolink:NamedThing oligosaccharide-lipid intermediate biosynthetic process The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation. got7fsn_ti oligosaccharide-lipid intermediate assembly|oligosaccharide-lipid intermediate biosynthetic process biological_process owl:Class
GO:0097147 biolink:NamedThing NOXA-BCL-2 complex A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:50:14Z cellular_component owl:Class
GO:0055078 biolink:NamedThing sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0055065 biolink:NamedThing metal ion homeostasis Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0000402 biolink:NamedThing crossed form four-way junction DNA binding Binding to a DNA segment containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands. got7fsn_ti crossed form Holliday junction binding molecular_function owl:Class
GO:0000400 biolink:NamedThing four-way junction DNA binding Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. got7fsn_ti forked DNA binding|Holliday junction binding molecular_function owl:Class
GO:0060756 biolink:NamedThing foraging behavior Behavior by which an organism locates food. got7fsn_ti dph 2009-06-22T02:46:25Z biological_process owl:Class
GO:0016006 biolink:NamedThing Nebenkern A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20737 cellular_component owl:Class
GO:0016007 biolink:NamedThing mitochondrial derivative The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20737 cellular_component owl:Class
GO:0047141 biolink:NamedThing glutathione-cystine transhydrogenase activity Catalysis of the reaction: cystine + 2 reduced glutathione = oxidized glutathione + 2 L-cysteine. got7fsn_ti GSH-cystine transhydrogenase|NADPH-dependent GSH-cystine transhydrogenase|glutathione:cystine oxidoreductase EC:1.8.4.4|MetaCyc:1.8.4.4-RXN|RHEA:12613 molecular_function owl:Class
GO:0009269 biolink:NamedThing response to desiccation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. got7fsn_ti desiccation tolerance biological_process owl:Class
GO:0009414 biolink:NamedThing response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water. got7fsn_ti response to drought|response to thirst|response to dehydration|drought tolerance biological_process owl:Class
GO:0016798 biolink:NamedThing hydrolase activity, acting on glycosyl bonds Catalysis of the hydrolysis of any glycosyl bond. got7fsn_ti glycosylase|glycosidase activity|N-glycosylase Reactome:R-HSA-1793176|EC:3.2.-.-|Reactome:R-HSA-2065233 molecular_function owl:Class
GO:0060734 biolink:NamedThing regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to endoplasmic reticulum stress. got7fsn_ti regulation of eIF2 alpha phosphorylation by ER stress|regulation of ER stress-induced eIF2 alpha phosphorylation|regulation of eIF2 alpha phosphorylation by endoplasmic reticulum stress dph 2009-06-12T02:15:16Z biological_process owl:Class
GO:0080135 biolink:NamedThing regulation of cellular response to stress Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti dhl 2009-05-06T05:02:52Z biological_process owl:Class
GO:0033945 biolink:NamedThing oligoxyloglucan reducing-end-specific cellobiohydrolase activity Catalysis of the hydrolysis of cellobiose from the reducing end of xyloglucans consisting of a beta-(1->4) linked glucan carrying alpha-D-xylosyl groups on O-6 of the glucose residues. To be a substrate, the first residue must be unsubstituted, the second residue may bear a xylosyl group, whether further glycosylated or not, and the third residue, which becomes the new terminus by the action of the enzyme, is preferably xylosylated, but this xylose residue must not be further substituted. got7fsn_ti oligoxyloglucan reducing end-specific cellobiohydrolase activity|oligoxyloglucan reducing-end cellobiohydrolase activity EC:3.2.1.150|MetaCyc:3.2.1.150-RXN molecular_function owl:Class
GO:0000912 biolink:NamedThing assembly of actomyosin apparatus involved in cytokinesis The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis. got7fsn_ti formation of actomyosin apparatus involved in cytokinesis|cytokinesis, formation of actomyosin apparatus|actomyosin apparatus assembly involved in cytokinesis biological_process owl:Class
GO:0045517 biolink:NamedThing interleukin-20 receptor binding Binding to an interleukin-20 receptor. got7fsn_ti IL-20|interleukin-20 receptor ligand molecular_function owl:Class
GO:0090382 biolink:NamedThing phagosome maturation A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. got7fsn_ti tb 2010-10-19T11:10:34Z biological_process owl:Class
GO:0034707 biolink:NamedThing chloride channel complex An ion channel complex through which chloride ions pass. got7fsn_ti cellular_component owl:Class
GO:0043997 biolink:NamedThing histone acetyltransferase activity (H4-K12 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). got7fsn_ti histone lysine N-acetyltransferase activity (H4-K12 specific) molecular_function owl:Class
GO:0010485 biolink:NamedThing H4 histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4. got7fsn_ti molecular_function owl:Class
GO:0021534 biolink:NamedThing cell proliferation in hindbrain The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain. got7fsn_ti biological_process owl:Class
GO:0022879 biolink:NamedThing protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti trehalose PTS transporter activity molecular_function owl:Class
GO:0048734 biolink:NamedThing proboscis morphogenesis The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head. got7fsn_ti biological_process owl:Class
GO:0048149 biolink:NamedThing behavioral response to ethanol Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus. got7fsn_ti behavioural response to ethanol biological_process owl:Class
GO:0090529 biolink:NamedThing cell septum assembly The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. got7fsn_ti cell septum assembly involved in cell cycle cytokinesis tb 2013-02-06T10:26:38Z GO:0090530 biological_process owl:Class
GO:0032506 biolink:NamedThing cytokinetic process A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells). got7fsn_ti biological_process owl:Class
GO:0004791 biolink:NamedThing thioredoxin-disulfide reductase activity Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide. got7fsn_ti thioredoxin reductase (NADPH) activity|thioredoxin disulfide reductase activity|NADPH2:oxidized thioredoxin oxidoreductase activity|thioredoxin-disulphide reductase activity|NADPH--thioredoxin reductase activity|thioredoxin:NADP+ oxidoreductase activity|NADPH:oxidized thioredoxin oxidoreductase activity|NADP--thioredoxin reductase activity RHEA:20345|Reactome:R-HSA-1222485|Reactome:R-HSA-73646|Reactome:R-HSA-3323050|EC:1.8.1.9|KEGG_REACTION:R02016|MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN|Reactome:R-HSA-9617735 molecular_function owl:Class
GO:0004421 biolink:NamedThing hydroxymethylglutaryl-CoA synthase activity Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). got7fsn_ti acetoacetyl coenzyme A transacetase activity|3-hydroxy-3-methylglutaryl-CoA synthase activity|3-hydroxy-3-methylglutaryl coenzyme A synthetase activity|HMG-CoA synthase activity|beta-hydroxy-beta-methylglutaryl-CoA synthase activity|3-hydroxy-3-methylglutaryl CoA synthetase activity|(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)|hydroxymethylglutaryl coenzyme A synthase activity|hydroxymethylglutaryl coenzyme A-condensing enzyme|3-hydroxy-3-methylglutaryl-coenzyme A synthase activity|acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)|hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity|3-hydroxy-3-methylglutaryl coenzyme A synthase activity|(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity Note that this function was formerly EC:4.1.3.5. Reactome:R-HSA-191323|KEGG_REACTION:R01978|RHEA:10188|MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN|Reactome:R-HSA-73918|EC:2.3.3.10 molecular_function owl:Class
GO:0031613 biolink:NamedThing nuclear proteasome regulatory particle, lid subcomplex The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell. got7fsn_ti cellular_component owl:Class
GO:0120229 biolink:NamedThing protein localization to motile cilium A process in which a protein is transported to, or maintained in, a location within a motile cilium. got7fsn_ti protein localization to nonmotile primary cilium https://github.com/geneontology/go-ontology/issues/19588 krc 2020-06-05T23:43:04Z biological_process owl:Class
GO:0061512 biolink:NamedThing protein localization to cilium A process in which a protein is transported to, or maintained in, a location within a cilium. got7fsn_ti dph 2013-03-22T15:41:44Z biological_process owl:Class
GO:0050588 biolink:NamedThing apo-beta-carotenoid-14',13'-dioxygenase activity Catalysis of the reaction: 8'-apo-beta-carotenol + O(2) = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal. got7fsn_ti apo-b-carotenoid-14',13'-dioxygenase activity|8'-apo-beta-carotenol:O2 oxidoreductase activity MetaCyc:1.13.12.12-RXN|EC:1.13.11.67|KEGG_REACTION:R08889|RHEA:26023 molecular_function owl:Class
GO:0051219 biolink:NamedThing phosphoprotein binding Binding to a phosphorylated protein. got7fsn_ti phosphorylated protein binding molecular_function owl:Class
GO:0048761 biolink:NamedThing collenchyma cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles. got7fsn_ti biological_process owl:Class
GO:0010090 biolink:NamedThing trichome morphogenesis The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana. got7fsn_ti trichome cell morphogenesis during differentiation GO:0048272 biological_process owl:Class
GO:0000904 biolink:NamedThing cell morphogenesis involved in differentiation The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. got7fsn_ti biological_process owl:Class
GO:0018049 biolink:NamedThing C-terminal peptidyl-serine amidation The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0096 biological_process owl:Class
GO:0032777 biolink:NamedThing Piccolo NuA4 histone acetyltransferase complex A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. got7fsn_ti cellular_component owl:Class
GO:0035267 biolink:NamedThing NuA4 histone acetyltransferase complex A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). got7fsn_ti TIP60 histone acetylase complex|TIP60 histone acetyltransferase complex cellular_component owl:Class
GO:0042696 biolink:NamedThing menarche The beginning of the menstrual cycle; the first menstrual cycle in an individual. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Menarche biological_process owl:Class
GO:0022601 biolink:NamedThing menstrual cycle phase The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0046293 biolink:NamedThing formaldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde. got7fsn_ti formaldehyde anabolism|formaldehyde synthesis|methanal biosynthesis|formaldehyde formation|formaldehyde biosynthesis|methanal biosynthetic process biological_process owl:Class
GO:0061037 biolink:NamedThing negative regulation of cartilage development Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. got7fsn_ti dph 2010-02-09T03:41:35Z biological_process owl:Class
GO:0061035 biolink:NamedThing regulation of cartilage development Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. got7fsn_ti dph 2010-02-09T03:41:35Z biological_process owl:Class
GO:0071567 biolink:NamedThing UFM1 hydrolase activity Catalysis of the hydrolysis of UFM1, a small ubiquitin-related modifier, from previously modified substrates. got7fsn_ti mah 2010-01-20T04:08:34Z molecular_function owl:Class
GO:0019783 biolink:NamedThing ubiquitin-like protein-specific protease activity Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated. got7fsn_ti ubiquitin-specific protease activity involved in negative regulation of ERAD pathway|small conjugating protein-specific protease activity|ubiquitin-like-protein-specific protease activity|ubiquitin-like specific protease activity|ubiquitin-specific protease activity involved in positive regulation of ERAD pathway GO:1904455|GO:1904454 molecular_function owl:Class
GO:0000144 biolink:NamedThing cellular bud neck septin ring A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange. got7fsn_ti cellular_component owl:Class
GO:0032161 biolink:NamedThing cleavage apparatus septin structure Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis. got7fsn_ti cellular_component owl:Class
GO:0070329 biolink:NamedThing tRNA seleno-modification The substitution of a selenium atom for a sulfur atom in a ribonucleotide in a tRNA molecule. got7fsn_ti tRNA base modification to selenouridine biological_process owl:Class
GO:0001887 biolink:NamedThing selenium compound metabolic process The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine. got7fsn_ti selenium metabolism|selenium compound metabolism|selenium metabolic process biological_process owl:Class
GO:1990773 biolink:NamedThing matrix metallopeptidase secretion The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins. got7fsn_ti matrix metalloproteinase secretion|MMP secretion sl 2015-06-15T19:12:06Z biological_process owl:Class
GO:0035018 biolink:NamedThing adult chitin-based cuticle pattern formation The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster. got7fsn_ti adult cuticle pattern formation biological_process owl:Class
GO:0016801 biolink:NamedThing hydrolase activity, acting on ether bonds Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. got7fsn_ti EC:3.3.-.- molecular_function owl:Class
GO:0061808 biolink:NamedThing negative regulation of DNA recombination at centromere Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination at the centromere. got7fsn_ti negative regulation of centromeric recombination dph 2016-11-10T15:24:50Z biological_process owl:Class
GO:0045910 biolink:NamedThing negative regulation of DNA recombination Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombination. got7fsn_ti down-regulation of DNA recombination|downregulation of DNA recombination|inhibition of DNA recombination|down regulation of DNA recombination biological_process owl:Class
GO:0070792 biolink:NamedThing Hulle cell development The process whose specific outcome is the progression of Hulle cells over time, from their formation to the mature structures. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body. got7fsn_ti Hulle cell formation|Huelle cell development mah 2009-07-08T02:54:30Z biological_process owl:Class
GO:0061436 biolink:NamedThing establishment of skin barrier Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability. got7fsn_ti skin barrier development|epithelial barrier development|establishment of epithelial barrier dph 2012-03-02T09:14:26Z biological_process owl:Class
GO:0033561 biolink:NamedThing regulation of water loss via skin A process that modulates the rate or extent of water loss from an organism via the skin. got7fsn_ti skin barrier function biological_process owl:Class
GO:0018060 biolink:NamedThing N-terminal peptidyl-cysteine deamination The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. got7fsn_ti biological_process owl:Class
GO:0006487 biolink:NamedThing protein N-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. got7fsn_ti N-glycan biosynthesis|N-glycan metabolism|protein amino acid N-linked glycosylation RESID:AA0151|RESID:AA0156|RESID:AA0327 biological_process owl:Class
GO:0010881 biolink:NamedThing regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. got7fsn_ti biological_process owl:Class
GO:0010880 biolink:NamedThing regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. got7fsn_ti biological_process owl:Class
GO:0045276 biolink:NamedThing plasma membrane respiratory chain complex III A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species. got7fsn_ti plasma membrane coenzyme Q-cytochrome c reductase complex|plasma membrane coenzyme Q-cytochrome c oxidoreductase complex|ubiquinol-cytochrome c oxidoreductase complex|ubiquinol-cytochrome-c reductase complex|plasma membrane cytochrome bc1 complex|plasma membrane ubiquinol-cytochrome-c reductase complex|respiratory chain complex III GO:0045286 cellular_component owl:Class
GO:0098797 biolink:NamedThing plasma membrane protein complex Any protein complex that is part of the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0044187 biolink:NamedThing host cell lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions. got7fsn_ti jl 2009-10-15T03:26:00Z cellular_component owl:Class
GO:0060366 biolink:NamedThing lambdoid suture morphogenesis The process in which the lambdoid suture is generated and organized. got7fsn_ti biological_process owl:Class
GO:0047777 biolink:NamedThing (S)-citramalyl-CoA lyase activity Catalysis of the reaction: (3S)-citramalyl-CoA = acetyl-CoA + pyruvate. got7fsn_ti (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)|(3S)-citramalyl-CoA lyase activity|citramalyl coenzyme A lyase activity|citramalyl-CoA lyase activity|(+)-CMA-CoA lyase activity|(3S)-citramalyl-CoA pyruvate-lyase activity MetaCyc:CITRAMALYL-COA-LYASE-RXN|EC:4.1.3.25|KEGG_REACTION:R00237|RHEA:22612 molecular_function owl:Class
GO:0004615 biolink:NamedThing phosphomannomutase activity Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. got7fsn_ti mannose phosphomutase activity|D-mannose 1,6-phosphomutase activity|phosphomannose mutase activity|alpha-D-mannose 1,6-phosphomutase activity GO:0008971 RHEA:11140|KEGG_REACTION:R01818|Reactome:R-HSA-3781926|MetaCyc:PHOSMANMUT-RXN|Reactome:R-HSA-446201|EC:5.4.2.8 molecular_function owl:Class
GO:1990028 biolink:NamedThing intermediate voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by an intermediate voltage-gated channel. An intermediate voltage-gated channel is a channel whose open state is dependent on intermediate voltage across the membrane in which it is embedded. got7fsn_ti R-type calcium channel pr 2013-02-06T20:55:41Z molecular_function owl:Class
GO:0050459 biolink:NamedThing ethanolamine-phosphate phospho-lyase activity Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate. got7fsn_ti amino alcohol O-phosphate phospholyase activity|O-phosphoethanolamine-phospholyase activity|ethanolamine-phosphate phospho-lyase (deaminating)|O-phosphorylethanol-amine phospho-lyase activity|ethanolamine-phosphate phospho-lyase (deaminating; acetaldehyde-forming) EC:4.2.3.2|Reactome:R-HSA-5696415|KEGG_REACTION:R00748|RHEA:17889|MetaCyc:ETHANOLAMINE-PHOSPHATE-PHOSPHO-LYASE-RXN molecular_function owl:Class
GO:0075043 biolink:NamedThing melanization of appressorium wall The process in which melanin is produced in the appressorium of the symbiont. Melanization of the appressorium increases turgor pressure in the appressorium. got7fsn_ti maintenance of turgor in appressorium by melanization|melanization of appressorium to maintain turgor pressure https://github.com/geneontology/go-ontology/issues/21505 biological_process owl:Class
GO:0043476 biolink:NamedThing pigment accumulation The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus. got7fsn_ti pigment accumulation in response to external stimulus biological_process owl:Class
GO:0001738 biolink:NamedThing morphogenesis of a polarized epithelium The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis. got7fsn_ti epithelial polarization biological_process owl:Class
GO:0030119 biolink:NamedThing AP-type membrane coat adaptor complex Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa). got7fsn_ti clathrin adaptor cellular_component owl:Class
GO:0044388 biolink:NamedThing small protein activating enzyme binding Binding to a small protein activating enzyme, such as ubiquitin-activating enzyme. got7fsn_ti jl 2011-12-15T04:28:17Z molecular_function owl:Class
GO:0002108 biolink:NamedThing maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0000470 biolink:NamedThing maturation of LSU-rRNA Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0070178 biolink:NamedThing D-serine metabolic process The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. got7fsn_ti D-serine metabolism biological_process owl:Class
GO:0009069 biolink:NamedThing serine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine. got7fsn_ti serine family amino acid metabolism biological_process owl:Class
GO:0071473 biolink:NamedThing cellular response to cation stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. got7fsn_ti mah 2009-12-18T11:49:46Z biological_process owl:Class
GO:0043157 biolink:NamedThing response to cation stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment. got7fsn_ti biological_process owl:Class
GO:0102382 biolink:NamedThing rebaudioside B glucosyltransferase activity Catalysis of the reaction: rebaudioside B + UDP-alpha-D-glucose <=> rebaudioside A + UDP + H+. got7fsn_ti MetaCyc:RXN-13518 molecular_function owl:Class
GO:0061284 biolink:NamedThing specification of mesonephric proximal tubule identity The process in which the proximal tubule of the mesonephric nephron acquires its identity. got7fsn_ti dph 2010-09-02T01:44:24Z biological_process owl:Class
GO:0061282 biolink:NamedThing specification of mesonephric nephron tubule identity The process in which the tubules arranged along the proximal/distal axis of the mesonephric nephron acquire their identity. got7fsn_ti dph 2010-09-02T01:37:44Z biological_process owl:Class
GO:0120236 biolink:NamedThing negative regulation of posttranslational protein targeting to membrane, translocation Any process that stops, prevents or reduces the frequency, rate or extent of posttranslational protein translocation through the ER membrane. got7fsn_ti negative regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation|negative regulation of posttranslational endoplasmic reticulum membrane protein translocation|negative regulation of N-terminal signal peptide-independent translocation into the ER https://github.com/geneontology/go-ontology/issues/19791 krc 2020-08-03T17:12:53Z biological_process owl:Class
GO:0097188 biolink:NamedThing dentin mineralization The process in which calcium salts are deposited into the calcareous tooth structure known as dentin. got7fsn_ti dentine mineralization pr 2011-11-21T09:05:43Z biological_process owl:Class
GO:0034505 biolink:NamedThing tooth mineralization The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum. got7fsn_ti tooth calcification biological_process owl:Class
GO:0090639 biolink:NamedThing phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine. got7fsn_ti tb 2015-04-23T15:56:12Z biological_process owl:Class
GO:0006656 biolink:NamedThing phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. got7fsn_ti phosphatidylcholine formation|phosphatidylcholine anabolism|phosphatidylcholine biosynthesis|phosphatidylcholine synthesis biological_process owl:Class
GO:0106150 biolink:NamedThing zearalenone biosynthetic process The chemical reactions and pathways resulting in the formation of zearalenone, a mycotoxin produced by several Fusarium species, is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals. got7fsn_ti hjd 2018-09-14T17:08:18Z biological_process owl:Class
GO:0007388 biolink:NamedThing posterior compartment specification The process involved in the specification of cell identity in the posterior compartments of the segmented embryo. got7fsn_ti biological_process owl:Class
GO:0007386 biolink:NamedThing compartment pattern specification The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation. got7fsn_ti compartment specification biological_process owl:Class
GO:0034949 biolink:NamedThing 1,1-dichloroethane reductive dehalogenase activity Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl. got7fsn_ti UM-BBD_reactionID:r1008|EC:1.97.1.- molecular_function owl:Class
GO:0017176 biolink:NamedThing phosphatidylinositol N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. got7fsn_ti UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity|uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity|uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity EC:2.4.1.198|RHEA:14789|MetaCyc:2.4.1.198-RXN molecular_function owl:Class
GO:0008912 biolink:NamedThing lactaldehyde reductase activity Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+. got7fsn_ti propanediol oxidoreductase activity|lactaldehyde:propanediol oxidoreductase activity|propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity|(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity EC:1.1.1.77 molecular_function owl:Class
GO:0036483 biolink:NamedThing neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. got7fsn_ti endoplasmic reticulum stress-induced neuron apoptosis|ER stress-induced neuron intrinsic apoptotic signaling pathway|endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|ER stress-induced neuron apoptosis bf 2014-08-14T13:33:23Z biological_process owl:Class
GO:0070059 biolink:NamedThing intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. got7fsn_ti intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress|apoptosis in response to ER stress|apoptosis in response to endoplasmic reticulum stress|apoptosis triggered by ER stress|endoplasmic reticulum stress-induced apoptosis|ER stress-induced apoptosis biological_process owl:Class
GO:0060115 biolink:NamedThing vestibular receptor cell fate commitment The process in which a cell becomes committed to become a vestibular receptor cell. got7fsn_ti vestibular hair cell fate commitment biological_process owl:Class
GO:0060120 biolink:NamedThing inner ear receptor cell fate commitment The process in which a cell becomes committed to become an inner ear receptor cell. got7fsn_ti inner ear hair cell fate commitment biological_process owl:Class
GO:0035327 biolink:NamedThing transcriptionally active chromatin The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed. got7fsn_ti bf 2010-02-26T10:23:02Z cellular_component owl:Class
GO:0018822 biolink:NamedThing nitrile hydratase activity Catalysis of the reaction: an aliphatic amide = a nitrile + H2O. got7fsn_ti L-NHase activity|aliphatic nitrile hydratase activity|NHase activity|3-cyanopyridine hydratase activity|acrylonitrile hydratase activity|nitrile hydro-lyase activity|H-NHase activity|aliphatic-amide hydro-lyase (nitrile-forming) EC:4.2.1.84|MetaCyc:NITRILE-HYDRATASE-RXN|RHEA:12673|UM-BBD_enzymeID:e0067 molecular_function owl:Class
GO:0046353 biolink:NamedThing aminoglycoside 3-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 3-N-acetylaminoglycoside. This is acetylation of the 3-amino group of the central deoxystreptamine ring. got7fsn_ti acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase activity|acetyl-CoA:gentamicin-C N3'-acetyltransferase activity|3-N-aminoglycoside acetyltransferase activity|aminoglycoside acetyltransferase AAC(3)-I activity|aminoglycoside acetyltransferase AAC(3)-1|gentamycin 3'-N-acetyltransferase activity|gentamicin acetyltransferase I activity|gentamicin-(3)-N-acetyltransferase activity|gentamycin acetyltransferase I|gentamicin 3'-N-acetyltransferase activity|3'-aminoglycoside acetyltransferase activity GO:0016991 MetaCyc:GENTAMICIN-3-N-ACETYLTRANSFERASE-RXN|EC:2.3.1.60|EC:2.3.1.81|MetaCyc:AMINOGLYCOSIDE-N3-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:0004661 biolink:NamedThing protein geranylgeranyltransferase activity Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. got7fsn_ti protein-cysteine geranylgeranyltransferase activity GO:0018224 molecular_function owl:Class
GO:0008318 biolink:NamedThing protein prenyltransferase activity Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. got7fsn_ti GO:0008244 molecular_function owl:Class
GO:0103069 biolink:NamedThing 17-hydroxyprogesterone 21-hydroxylase activity Catalysis of the reaction: 17alpha-hydroxyprogesterone + O2 + reduced [NADPH--hemoprotein reductase] = 11-deoxycortisol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti MetaCyc:RXN66-356|RHEA:50308 molecular_function owl:Class
GO:0004509 biolink:NamedThing steroid 21-monooxygenase activity Catalysis of the reaction: A C(21) steroid + [reduced NADPH--hemoprotein reductase] + O(2) = a 21-hydroxy-C(21)-steroid + [oxidized NADPH--hemoprotein reductase] + H(2)O. got7fsn_ti cytochrome P450 CYP21A1|steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)|21-hydroxylase activity|cytochrome p450 XXIA1 activity|steroid 21-hydroxylase activity Reactome:R-HSA-193981|EC:1.14.14.16|Reactome:R-HSA-193964|MetaCyc:STEROID-21-MONOOXYGENASE-RXN|RHEA:65612|Reactome:R-HSA-5601976 molecular_function owl:Class
GO:0002770 biolink:NamedThing T cell inhibitory signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response. got7fsn_ti T-lymphocyte inhibitory signaling pathway|T cell inhibitory signalling pathway|T-cell inhibitory signaling pathway|T lymphocyte inhibitory signaling pathway biological_process owl:Class
GO:0009636 biolink:NamedThing response to toxic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. got7fsn_ti detoxification response|toxin resistance|toxin susceptibility/resistance biological_process owl:Class
GO:0008579 biolink:NamedThing JUN kinase phosphatase activity Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate. got7fsn_ti molecular_function owl:Class
GO:0008138 biolink:NamedThing protein tyrosine/serine/threonine phosphatase activity Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. got7fsn_ti dual-specificity protein phosphatase https://github.com/geneontology/go-ontology/issues/12183 Note that this term applies only to free amino acids. Consider 'protein serine/threonine phosphatase activity' or 'protein tyrosine/serine/threonine phosphatase activity' if you want to annotate a protein phosphatase. Reactome:R-HSA-5675376|Reactome:R-HSA-5675373|Reactome:R-HSA-9652816 molecular_function owl:Class
GO:0016472 biolink:NamedThing sodium ion-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis. got7fsn_ti sodium-transporting two-sector ATPase complex cellular_component owl:Class
GO:0042728 biolink:NamedThing flavin-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. got7fsn_ti riboflavin and derivative catabolism|vitamin B2 and derivative catabolic process|flavin-containing compound catabolic process degradation|vitamin B2 and derivative catabolism|flavin-containing compound catabolic process breakdown|flavin-containing compound catabolism|riboflavin and derivative catabolic process biological_process owl:Class
GO:0005821 biolink:NamedThing intermediate layer of spindle pole body Structure between the central and outer plaques of the spindle pole body. got7fsn_ti cellular_component owl:Class
GO:0050491 biolink:NamedThing sulcatone reductase activity Catalysis of the reaction: NAD(+) + sulcatol = H(+) + NADH + sulcatone. got7fsn_ti sulcatol:NAD+ oxidoreductase activity MetaCyc:1.1.1.260-RXN|EC:1.1.1.260|KEGG_REACTION:R05678|RHEA:24484 molecular_function owl:Class
GO:0090660 biolink:NamedThing cerebrospinal fluid circulation The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional. got7fsn_ti CSF circulation|CSF flow|cerebrospinal fluid flow tb 2015-09-11T15:49:59Z biological_process owl:Class
GO:0102456 biolink:NamedThing cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-sinapoyl-beta-D-glucose <=> cyanin betaine + trans-sinapate + H+. got7fsn_ti MetaCyc:RXN-13967 molecular_function owl:Class
GO:0060943 biolink:NamedThing neural crest-derived cardiac fibroblast cell development The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation from a neural crest cell to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T02:31:24Z biological_process owl:Class
GO:0060936 biolink:NamedThing cardiac fibroblast cell development The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T01:23:03Z biological_process owl:Class
GO:0030351 biolink:NamedThing inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate. got7fsn_ti Reactome:R-HSA-1855163 molecular_function owl:Class
GO:0072549 biolink:NamedThing monocoumaroyl dicaffeoyl spermidine meta-hydroxylase activity Catalysis of the reaction: monocoumaroyl dicaffeoyl spermidine + NADPH + O2 = tricaffeoyl spermidine + NADP+ + H2O. got7fsn_ti mah 2011-01-25T02:58:04Z molecular_function owl:Class
GO:0072533 biolink:NamedThing tri-(coumaroyl or caffeoyl) spermidine meta-hydroxylase activity Catalysis of the meta-hydroxylation of any of the three phenolic rings on tricoumaroyl spermidine or any of its mono- or dicaffeoyl spermidine derivatives. got7fsn_ti Note that the overall reaction representing three successive executions of this activity is N1,N5,N10-tricoumaroyl spermidine + 3 NADPH + 3 O2 = N1,N5,N10-tricaffeoyl spermidine + 3 NADP+ + 3 H2O; this corresponds to the MetaCyc reaction RXN-11260 (http://biocyc.org/META/NEW-IMAGE?type=REACTION&object=RXN-11260). mah 2011-01-12T02:03:07Z molecular_function owl:Class
GO:0021820 biolink:NamedThing extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells. got7fsn_ti organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration|extracellular matrix organisation in marginal zone involved in cerebral cortex radial glia guided migration biological_process owl:Class
GO:0102671 biolink:NamedThing 6a-hydroxymaackiain-3-O-methyltransferase activity Catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> H+ + (+)-pisatin + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.270|RHEA:35471|MetaCyc:RXN-4002 molecular_function owl:Class
GO:0046629 biolink:NamedThing gamma-delta T cell activation The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti gamma-delta T-lymphocyte activation|gamma-delta T lymphocyte activation|gamma-delta T-cell activation biological_process owl:Class
GO:0015800 biolink:NamedThing acidic amino acid transport The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0006865 biolink:NamedThing amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti GO:0006866 biological_process owl:Class
GO:0098005 biolink:NamedThing viral head-tail joining Process by which virus heads and tails are attached to each other. got7fsn_ti phage head tail joining|virus head-tail joining bm 2012-07-18T16:11:59Z biological_process owl:Class
GO:0061584 biolink:NamedThing hypocretin secretion The controlled release of hypocretin from a cell or a tissue. got7fsn_ti orexin secretion dph 2013-12-26T10:07:38Z biological_process owl:Class
GO:0002790 biolink:NamedThing peptide secretion The controlled release of a peptide from a cell or a tissue. got7fsn_ti biological_process owl:Class
GO:0044696 biolink:NamedThing killing by virus of host cell by post-segregational killing The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes. got7fsn_ti killing by virus of host cell by toxin-antitoxin system|killing by virus of host cell by PSK Note that this process occurs after the cell division partitioning event. jl 2012-08-16T13:58:18Z biological_process owl:Class
GO:0039633 biolink:NamedThing killing by virus of host cell Any process mediated by a virus that results in the death of a cell in the host organism. got7fsn_ti killing by virus of host cells|killing by phage of host cells bf 2012-08-10T14:44:40Z biological_process owl:Class
GO:0043063 biolink:NamedThing intercellular bridge organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another. got7fsn_ti intercellular bridge organization and biogenesis|intercellular bridge organisation biological_process owl:Class
GO:0043062 biolink:NamedThing extracellular structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite. got7fsn_ti extracellular structure organisation|extracellular structure organization and biogenesis biological_process owl:Class
GO:0048744 biolink:NamedThing negative regulation of skeletal muscle fiber development Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. got7fsn_ti negative regulation of skeletal muscle fibre development|down regulation of skeletal muscle fiber development|negative regulation of skeletal myofiber development|negative regulation of skeletal myofibre development|downregulation of skeletal muscle fiber development|down-regulation of skeletal muscle fiber development|inhibition of skeletal muscle fiber development biological_process owl:Class
GO:0051154 biolink:NamedThing negative regulation of striated muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation. got7fsn_ti down regulation of striated muscle cell differentiation|inhibition of striated muscle cell differentiation|down-regulation of striated muscle cell differentiation|downregulation of striated muscle cell differentiation biological_process owl:Class
GO:0099645 biolink:NamedThing neurotransmitter receptor localization to postsynaptic specialization membrane A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). got7fsn_ti neurotransmitter receptor localisation in postsynaptic specialization membrane biological_process owl:Class
GO:0099072 biolink:NamedThing regulation of postsynaptic membrane neurotransmitter receptor levels Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane. got7fsn_ti biological_process owl:Class
GO:0060717 biolink:NamedThing chorion development The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane. got7fsn_ti dph 2009-06-11T02:37:50Z biological_process owl:Class
GO:0042180 biolink:NamedThing cellular ketone metabolic process The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. got7fsn_ti ketone metabolism biological_process owl:Class
GO:0045325 biolink:NamedThing peptidyl-tryptophan hydroxylation The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan. got7fsn_ti RESID:AA0322 biological_process owl:Class
GO:0120103 biolink:NamedThing centriolar subdistal appendage A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68. got7fsn_ti subdistal appendage of mother centriole|subdistal appendage of centriole|subdistal appendage of basal body krc 2017-10-10T15:31:40Z cellular_component owl:Class
GO:0000113 biolink:NamedThing nucleotide-excision repair factor 4 complex One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p. got7fsn_ti NEF4 complex Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. cellular_component owl:Class
GO:0030857 biolink:NamedThing negative regulation of epithelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation. got7fsn_ti inhibition of epithelial cell differentiation|down-regulation of epithelial cell differentiation|downregulation of epithelial cell differentiation|down regulation of epithelial cell differentiation biological_process owl:Class
GO:0030856 biolink:NamedThing regulation of epithelial cell differentiation Any process that modulates the frequency, rate or extent of epithelial cell differentiation. got7fsn_ti biological_process owl:Class
GO:0031692 biolink:NamedThing alpha-1B adrenergic receptor binding Binding to an alpha-1B adrenergic receptor. got7fsn_ti alpha-1B adrenergic receptor ligand molecular_function owl:Class
GO:0033038 biolink:NamedThing bitter taste receptor activity Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. got7fsn_ti molecular_function owl:Class
GO:0072149 biolink:NamedThing glomerular visceral epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. got7fsn_ti podocyte cell fate commitment mah 2010-02-24T02:08:03Z biological_process owl:Class
GO:0003172 biolink:NamedThing sinoatrial valve development The progression of the sinoatrial valve over time, from its formation to the mature structure. got7fsn_ti SA valve development dph 2009-10-08T11:15:39Z biological_process owl:Class
GO:0003170 biolink:NamedThing heart valve development The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion. got7fsn_ti cardiac valve development dph 2009-10-08T10:50:09Z biological_process owl:Class
GO:0071489 biolink:NamedThing cellular response to red or far red light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti mah 2009-12-18T02:18:25Z biological_process owl:Class
GO:0031751 biolink:NamedThing D4 dopamine receptor binding Binding to a D4 dopamine receptor. got7fsn_ti D4 dopamine receptor ligand molecular_function owl:Class
GO:0050780 biolink:NamedThing dopamine receptor binding Binding to a dopamine receptor. got7fsn_ti molecular_function owl:Class
GO:0032838 biolink:NamedThing plasma membrane bounded cell projection cytoplasm All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection. got7fsn_ti cellular_component owl:Class
GO:0099568 biolink:NamedThing cytoplasmic region Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. got7fsn_ti cellular_component owl:Class
GO:0060462 biolink:NamedThing lung lobe development The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung. got7fsn_ti biological_process owl:Class
GO:0043792 biolink:NamedThing enamidase activity Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+). got7fsn_ti 6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase activity KEGG_REACTION:R07984|EC:3.5.2.18|MetaCyc:3.5.2.18-RXN|RHEA:17209 molecular_function owl:Class
GO:0009486 biolink:NamedThing cytochrome bo3 ubiquinol oxidase activity Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]. got7fsn_ti cytochrome o ubiquinol oxidase activity|cytochrome bo(3) oxidase|cytochrome bo oxidase https://github.com/geneontology/go-ontology/issues/20924 GO:0008827 RHEA:30251|EC:7.1.1.3|MetaCyc:RXN0-5268|TC:3.D.4.5.1 molecular_function owl:Class
GO:0009055 biolink:NamedThing electron transfer activity Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. got7fsn_ti electron transporter activity|electron carrier|electron acceptor activity|electron donor activity https://github.com/geneontology/go-ontology/issues/21334 Note that this term should only be be used for electron transfer that generates a transmembrane electrochemical gradient, e.g. components of the respiratory or photosynthetic electron transport chain. GO:0009053|GO:0009054 Reactome:R-HSA-169260|Reactome:R-HSA-2564826 molecular_function owl:Class
GO:0044199 biolink:NamedThing host cell nuclear envelope The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). got7fsn_ti jl 2009-10-21T10:56:11Z cellular_component owl:Class
GO:0097610 biolink:NamedThing cell surface furrow A furrow that may be found on the cell surface. Examples include the cingulum and sulcus found in some dinoflagellates. got7fsn_ti cell surface groove|furrow|groove pr 2014-06-09T11:22:38Z cellular_component owl:Class
GO:0052130 biolink:NamedThing negative aerotaxis The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen. got7fsn_ti biological_process owl:Class
GO:0050919 biolink:NamedThing negative chemotaxis The directed movement of a motile cell or organism towards a lower concentration of a chemical. got7fsn_ti chemoaversion|chemorepulsion biological_process owl:Class
GO:0038156 biolink:NamedThing interleukin-3-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-3 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-3-mediated signaling pathway|interleukin-3-mediated signalling pathway bf 2012-05-11T11:50:42Z biological_process owl:Class
GO:1990299 biolink:NamedThing Bub1-Bub3 complex localization to kinetochore A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. got7fsn_ti al 2014-02-26T09:29:13Z biological_process owl:Class
GO:0090527 biolink:NamedThing actin filament reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments. got7fsn_ti tb 2013-01-23T10:27:44Z biological_process owl:Class
GO:0106388 biolink:NamedThing 18S rRNA aminocarboxypropyltransferase activity Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine. got7fsn_ti hjd 2021-07-13T14:01:28Z RHEA:63296 molecular_function owl:Class
GO:0140102 biolink:NamedThing catalytic activity, acting on a rRNA Catalytic activity that acts to modify a ribosomal RNA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14225 pg 2017-09-15T19:00:57Z molecular_function owl:Class
GO:0043126 biolink:NamedThing regulation of 1-phosphatidylinositol 4-kinase activity Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase. got7fsn_ti regulation of PI4K activity biological_process owl:Class
GO:0043550 biolink:NamedThing regulation of lipid kinase activity Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. got7fsn_ti biological_process owl:Class
GO:0009850 biolink:NamedThing auxin metabolic process The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth. got7fsn_ti auxin metabolism biological_process owl:Class
GO:0002002 biolink:NamedThing regulation of angiotensin levels in blood The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation. got7fsn_ti regulation of blood angiotensin level|control of angiotensin levels in blood|control of blood angiotensin level https://github.com/geneontology/go-ontology/issues/15424 biological_process owl:Class
GO:0010817 biolink:NamedThing regulation of hormone levels Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. got7fsn_ti biological_process owl:Class
GO:0004098 biolink:NamedThing cerebroside-sulfatase activity Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate. got7fsn_ti arylsulfatase A activity|cerebroside-sulphatase activity|cerebroside sulfate sulfatase activity|cerebroside-3-sulfate 3-sulfohydrolase activity Reactome:R-HSA-1606807|EC:3.1.6.8|RHEA:21300|MetaCyc:CEREBROSIDE-SULFATASE-RXN molecular_function owl:Class
GO:0003848 biolink:NamedThing 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+). got7fsn_ti 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity|H2-pteridine-CH2OH pyrophosphokinase activity|7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity|ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity|7,8-dihydroxymethylpterin-pyrophosphokinase activity|6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity|6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity|hydroxymethyldihydropteridine pyrophosphokinase activity|7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity|HPPK MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN|RHEA:11412|KEGG_REACTION:R03503|EC:2.7.6.3 molecular_function owl:Class
GO:0052091 biolink:NamedThing modulation by symbiont of nutrient release from host Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0044003 biolink:NamedThing modulation by symbiont of host process The process in which a symbiont organism effects a change in the structure or processes of its host organism. got7fsn_ti modulation by symbiont of host system process|disruption by symbiont of host cell|pathogenesis|modification by symbiont of host biological process|regulation by symbiont of host system process|modification by symbiont of host morphology or physiology https://github.com/geneontology/go-ontology/issues/18719 GO:0044055|GO:0044004 biological_process owl:Class
GO:0001588 biolink:NamedThing dopamine neurotransmitter receptor activity, coupled via Gs Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. got7fsn_ti dopamine D1 receptor activity|dopamine D5 receptor activity GO:0001590|GO:0001589 molecular_function owl:Class
GO:0004952 biolink:NamedThing dopamine neurotransmitter receptor activity Combining with the neurotransmitter dopamine to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0002489 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent|TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway|TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway biological_process owl:Class
GO:0002488 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway biological_process owl:Class
GO:0000473 biolink:NamedThing maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0035758 biolink:NamedThing chemokine (C-C motif) ligand 21 binding Binding to chemokine (C-C motif) ligand 21. got7fsn_ti CCL21 binding bf 2011-03-25T02:03:53Z molecular_function owl:Class
GO:0042038 biolink:NamedThing peptidyl-histidine methylation, to form tele-methylhistidine The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine). got7fsn_ti peptidyl-histidine tele-methylation GO:0042261 RESID:AA0317 biological_process owl:Class
GO:0071721 biolink:NamedThing sodium-independent thromboxane transport The directed, sodium-independent, movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels. got7fsn_ti mah 2010-03-10T03:10:45Z biological_process owl:Class
GO:0035071 biolink:NamedThing salivary gland cell autophagic cell death The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis. got7fsn_ti salivary gland cell death|autophagic cell death of salivary gland cells|salivary gland cell programmed cell death by autophagy|programmed cell death of salivary gland cells by autophagy biological_process owl:Class
GO:0035781 biolink:NamedThing CD86 biosynthetic process The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival. got7fsn_ti CD86 synthesis|CD86 formation|CD86 biosynthesis|CD86 anabolism bf 2011-04-04T11:20:40Z biological_process owl:Class
GO:0009752 biolink:NamedThing detection of salicylic acid stimulus The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of salicylic acid stimulus biological_process owl:Class
GO:0009751 biolink:NamedThing response to salicylic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. got7fsn_ti response to salicylate|response to salicylic acid stimulus biological_process owl:Class
GO:0009525 biolink:NamedThing phragmosome A flattened membranous vesicle containing cell wall components. got7fsn_ti Wikipedia:Phragmosome cellular_component owl:Class
GO:0044784 biolink:NamedThing metaphase/anaphase transition of cell cycle The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle. got7fsn_ti jl 2013-05-02T13:09:34Z biological_process owl:Class
GO:0033045 biolink:NamedThing regulation of sister chromatid segregation Any process that modulates the frequency, rate or extent of sister chromatid segregation. got7fsn_ti biological_process owl:Class
GO:0007460 biolink:NamedThing R8 cell fate commitment The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium. got7fsn_ti restriction of R8 fate GO:0007461 biological_process owl:Class
GO:0001752 biolink:NamedThing compound eye photoreceptor fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. got7fsn_ti GO:0007459 biological_process owl:Class
GO:0072515 biolink:NamedThing trehalose transport in response to desiccation The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of a desiccation stimulus. A desiccation stimulus signals extreme dryness resulting from the prolonged deprivation of water. got7fsn_ti mah 2010-12-21T11:30:31Z biological_process owl:Class
GO:0072514 biolink:NamedThing trehalose transport in response to water deprivation The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, that occurs as a result of deprivation of water. got7fsn_ti mah 2010-12-21T11:26:14Z biological_process owl:Class
GO:0034356 biolink:NamedThing NAD biosynthesis via nicotinamide riboside salvage pathway The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside. got7fsn_ti nicotinamide riboside salvage pathway|NR salvage pathway biological_process owl:Class
GO:0009435 biolink:NamedThing NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. got7fsn_ti oxidized nicotinamide adenine dinucleotide biosynthesis|reduced NAD biosynthesis|oxidized nicotinamide adenine dinucleotide biosynthetic process|nicotinamide adenine dinucleotide biosynthetic process|NAD (oxidized) biosynthesis|nicotinamide adenine dinucleotide biosynthesis|NADH biosynthetic process|NAD (reduced) biosynthetic process|reduced nicotinamide adenine dinucleotide biosynthesis|reduced nicotinamide adenine dinucleotide biosynthetic process|NAD anabolism|NAD formation|NAD (oxidized) biosynthetic process|NAD (reduced) biosynthesis|oxidized NAD biosynthesis|oxidized NAD biosynthetic process|NAD synthesis|NAD biosynthesis|NADH biosynthesis|reduced NAD biosynthetic process GO:0006736 biological_process owl:Class
GO:0043713 biolink:NamedThing (R)-2-hydroxyisocaproate dehydrogenase activity Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+. got7fsn_ti molecular_function owl:Class
GO:0050908 biolink:NamedThing detection of light stimulus involved in visual perception The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. got7fsn_ti sensory detection of light stimulus during visual perception|sensory detection of light during visual perception|sensory transduction of light stimulus during visual perception|sensory transduction of light during visual perception|visual perception, sensory transduction of light stimulus|visual perception, sensory transduction during perception of light|visual perception, detection of light stimulus biological_process owl:Class
GO:0031865 biolink:NamedThing EP2 subtype prostaglandin E2 receptor binding Binding to an EP2 subtype prostaglandin E2 receptor. got7fsn_ti EP2 subtype prostaglandin E2 receptor ligand|prostanoid EP2 receptor binding molecular_function owl:Class
GO:0039702 biolink:NamedThing viral budding via host ESCRT complex Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process. got7fsn_ti host-assisted viral budding|viral budding through the ESCRT machinery bf 2013-11-06T16:51:53Z VZ:1536 biological_process owl:Class
GO:0046755 biolink:NamedThing viral budding A viral process by which enveloped viruses acquire a host-derived membrane enriched in viral proteins to form their external envelope. The process starts when nucleocapsids, assembled or in the process of being built, induce formation of a membrane curvature in the host plasma or organelle membrane and wrap up in the forming bud. The process ends when the bud is eventually pinched off by membrane scission to release the enveloped particle into the lumenal or extracellular space. got7fsn_ti virus budding|viral capsid envelopment|virion budding GO:0046744 VZ:1947 biological_process owl:Class
GO:0031104 biolink:NamedThing dendrite regeneration The regrowth of dendrites in response to their loss or damage. got7fsn_ti biological_process owl:Class
GO:0016358 biolink:NamedThing dendrite development The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0004140 biolink:NamedThing dephospho-CoA kinase activity Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+). got7fsn_ti 3'-dephospho-CoA kinase activity|ATP:dephospho-CoA 3'-phosphotransferase activity|dephosphocoenzyme A kinase (phosphorylating)|dephosphocoenzyme A kinase activity RHEA:18245|KEGG_REACTION:R00130|MetaCyc:DEPHOSPHOCOAKIN-RXN|EC:2.7.1.24|Reactome:R-HSA-196773 molecular_function owl:Class
GO:0072233 biolink:NamedThing metanephric thick ascending limb development The process whose specific outcome is the progression of the metanephric thick ascending limb over time, from its formation to the mature structure. The metanephric thick ascending limb is the last part of the metanephric loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule. got7fsn_ti metanephric TAL development mah 2010-03-18T03:39:36Z biological_process owl:Class
GO:0072023 biolink:NamedThing thick ascending limb development The process whose specific outcome is the progression of the thick ascending limb over time, from its formation to the mature structure. The thick ascending limb is the last part of the loop of Henle. Its thick, mitochondria-rich epithelium characterizes the outer medulla, and is responsible for very avid active salt transport. At the macula densa, the thick ascending limb connects to the distal convoluted tubule. got7fsn_ti TAL development mah 2010-01-25T02:39:51Z GO:0072026 biological_process owl:Class
GO:1902463 biolink:NamedThing protein localization to cell leading edge A process in which a protein is transported to, or maintained in, a location within a cell leading edge. got7fsn_ti protein localization in cell leading edge|protein localisation in cell leading edge|protein localisation to cell leading edge jl 2013-10-22T12:36:07Z biological_process owl:Class
GO:0005093 biolink:NamedThing Rab GDP-dissociation inhibitor activity Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. got7fsn_ti molecular_function owl:Class
GO:0043955 biolink:NamedThing 3-hydroxypropionyl-CoA synthetase activity Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate. got7fsn_ti acetyl-coenzyme A synthetase/GroES-like domain|enoyl-CoA hydratase/isomerase|acetyl-coenzyme A synthetase|AMP-dependent synthetase and ligase|3-hydroxy propionyl-CoA synthetase activity|AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. RHEA:26534|EC:6.2.1.36 molecular_function owl:Class
GO:0051826 biolink:NamedThing negative regulation of synapse structural plasticity Any process that stops, prevents, or reduces the frequency, rate or extent of synapse structural plasticity. got7fsn_ti down regulation of synapse structural plasticity|downregulation of synapse structural plasticity|inhibition of synapse structural plasticity|down-regulation of synapse structural plasticity biological_process owl:Class
GO:0051129 biolink:NamedThing negative regulation of cellular component organization Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. got7fsn_ti negative regulation of cell organisation|downregulation of cell organization|down-regulation of cell organization|inhibition of cell organization|negative regulation of cellular component organization and biogenesis|down regulation of cell organization biological_process owl:Class
GO:0035660 biolink:NamedThing MyD88-dependent toll-like receptor 4 signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. got7fsn_ti MyD88-dependent toll-like receptor 4 signalling pathway|MyD88-dependent TLR4 signaling pathway bf 2011-02-01T10:10:04Z biological_process owl:Class
GO:0034142 biolink:NamedThing toll-like receptor 4 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 4. got7fsn_ti TLR4 signaling pathway|toll-like receptor 4 signalling pathway biological_process owl:Class
GO:0015367 biolink:NamedThing oxoglutarate:malate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out). got7fsn_ti 2-oxoglutarate/malate carrier protein Reactome:R-HSA-376851|Reactome:R-HSA-198440 molecular_function owl:Class
GO:0015140 biolink:NamedThing malate transmembrane transporter activity Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. got7fsn_ti dicarboxylate (succinate/fumarate/malate) antiporter activity molecular_function owl:Class
GO:0006903 biolink:NamedThing vesicle targeting The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo. got7fsn_ti biological_process owl:Class
GO:0019887 biolink:NamedThing protein kinase regulator activity Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. got7fsn_ti molecular_function owl:Class
GO:0019207 biolink:NamedThing kinase regulator activity Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. got7fsn_ti molecular_function owl:Class
GO:0033113 biolink:NamedThing cyanelle membrane Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope. got7fsn_ti cellular_component owl:Class
GO:0016590 biolink:NamedThing ACF complex An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair. got7fsn_ti ATP-utilizing chromatin assembly and remodeling factor complex cellular_component owl:Class
GO:0034889 biolink:NamedThing endosulfan hemisulfate sulfatase activity Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate. got7fsn_ti UM-BBD_reactionID:r1384 molecular_function owl:Class
GO:0016787 biolink:NamedThing hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. got7fsn_ti Reactome:R-HSA-2029475|Reactome:R-HSA-6788295|Reactome:R-HSA-5694583|Reactome:R-HSA-1236938|Reactome:R-HSA-8938314|Reactome:R-HSA-5695964|EC:3.-.-.-|Reactome:R-HSA-8952137|Reactome:R-HSA-6786190 molecular_function owl:Class
GO:0070253 biolink:NamedThing somatostatin secretion The regulated release of somatostatin from secretory granules in the D cells of the pancreas. got7fsn_ti biological_process owl:Class
GO:0060430 biolink:NamedThing lung saccule development The biological process whose specific outcome is the progression of a lung saccule from an initial condition to its mature state. The lung saccule is the primitive gas exchange portion of the lung composed of type I and type II cells. got7fsn_ti lung saccular development biological_process owl:Class
GO:0098753 biolink:NamedThing anchored component of the cytoplasmic side of the plasma membrane The component of the plasma membrane consisting of gene products and protein complexes with covalently attached hydrophobic anchors products that penetrate only the cytoplasmic side of the membrane. got7fsn_ti Examples include many myristoylated proteins. cellular_component owl:Class
GO:0031235 biolink:NamedThing intrinsic component of the cytoplasmic side of the plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only. got7fsn_ti intrinsic to internal side of plasma membrane|intrinsic to internal leaflet of plasma membrane|intrinsic to cytoplasmic side of plasma membrane cellular_component owl:Class
GO:0045606 biolink:NamedThing positive regulation of epidermal cell differentiation Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation. got7fsn_ti positive regulation of hypodermal cell differentiation|upregulation of epidermal cell differentiation|up-regulation of epidermal cell differentiation|stimulation of epidermal cell differentiation|activation of epidermal cell differentiation|up regulation of epidermal cell differentiation biological_process owl:Class
GO:0045604 biolink:NamedThing regulation of epidermal cell differentiation Any process that modulates the frequency, rate or extent of epidermal cell differentiation. got7fsn_ti regulation of hypodermal cell differentiation biological_process owl:Class
GO:0035235 biolink:NamedThing ionotropic glutamate receptor signaling pathway A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti ionotropic glutamate receptor signalling pathway biological_process owl:Class
GO:0007215 biolink:NamedThing glutamate receptor signaling pathway A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti glutamate signaling pathway|glutamate signalling pathway biological_process owl:Class
GO:0031672 biolink:NamedThing A band The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line. got7fsn_ti Q disc|transverse disc|A disc|anisotropic disc Wikipedia:Sarcomere#bands cellular_component owl:Class
GO:0010172 biolink:NamedThing embryonic body morphogenesis The process in which the anatomical structures of the embryonic soma are generated and organized. got7fsn_ti biological_process owl:Class
GO:0010171 biolink:NamedThing body morphogenesis The process in which the anatomical structures of the soma are generated and organized. got7fsn_ti biological_process owl:Class
GO:0010478 biolink:NamedThing chlororespiration A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool. got7fsn_ti biological_process owl:Class
GO:0022904 biolink:NamedThing respiratory electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. got7fsn_ti dihydrolipoylprotein reduction|electron transfer|dihydrolipoamide reduction|oxidized glutathione reduction|dihydrobiopterin reduction|dihydropteridine reduction|protein-disulfide reduction|6-phosphofructokinase reduction|other pathways of electron transport Wikipedia:Electron_transfer biological_process owl:Class
GO:0042588 biolink:NamedThing zymogen granule A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. got7fsn_ti cellular_component owl:Class
GO:0050611 biolink:NamedThing arsenate reductase (azurin) activity Catalysis of the reaction: H(2)O + arsenite + 2 oxidized azurin = 2 H(+) + 2 reduced azurin + arsenate. got7fsn_ti arsenite:azurin oxidoreductase activity|arsenite oxidase activity GO:0018691 UM-BBD_reactionID:r0634|RHEA:18701|MetaCyc:1.20.98.1-RXN|EC:1.20.9.1 molecular_function owl:Class
GO:0052882 biolink:NamedThing oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein. got7fsn_ti EC:1.20.9.- molecular_function owl:Class
GO:0042251 biolink:NamedThing maintenance of polarity of larval imaginal disc epithelium The maintenance of an established polarized larval imaginal disc epithelium. got7fsn_ti biological_process owl:Class
GO:0016336 biolink:NamedThing establishment or maintenance of polarity of larval imaginal disc epithelium Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium. got7fsn_ti biological_process owl:Class
GO:0007073 biolink:NamedThing positive regulation of transcription involved in exit from mitosis, from RNA polymerase I promoter Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. got7fsn_ti activation of transcription on exit from mitosis, from RNA polymerase I promoter|activation of transcription on exit from mitosis, from Pol I promoter biological_process owl:Class
GO:0033820 biolink:NamedThing DNA alpha-glucosyltransferase activity Catalysis of the transfer of an alpha-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA. got7fsn_ti uridine diphosphoglucose-deoxyribonucleate alpha-glucosyltransferase activity|UDP-glucose:DNA alpha-D-glucosyltransferase activity|T4-HMC-alpha-glucosyl transferase activity|UDPglucose-DNA alpha-glucosyltransferase activity|T6-HMC-alpha-glucosyl transferase activity|T2-HMC-alpha-glucosyl transferase activity MetaCyc:2.4.1.26-RXN|EC:2.4.1.26 molecular_function owl:Class
GO:0097310 biolink:NamedThing cap2 mRNA methylation Methylation of the ribose of the first and second nucleotides of a 5'-capped mRNA. got7fsn_ti cap2 mRNA capping pr 2012-05-23T04:05:07Z biological_process owl:Class
GO:0036451 biolink:NamedThing cap mRNA methylation Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA. got7fsn_ti bf 2013-11-06T14:36:00Z biological_process owl:Class
GO:0048873 biolink:NamedThing homeostasis of number of cells within a tissue Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue. got7fsn_ti biological_process owl:Class
GO:0045545 biolink:NamedThing syndecan binding Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. got7fsn_ti molecular_function owl:Class
GO:0043394 biolink:NamedThing proteoglycan binding Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. got7fsn_ti molecular_function owl:Class
GO:0071766 biolink:NamedThing Actinobacterium-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Actinobacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. Actinobacterial cell walls contain characteristic mycolic acids, of which some are covalently linked to the cell wall peptidoglycan and others accumulate at the cell surface. got7fsn_ti mah 2010-03-29T04:12:51Z biological_process owl:Class
GO:0009273 biolink:NamedThing peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. got7fsn_ti cell envelope biosynthesis|cell wall assembly|cell wall biosynthetic process|cell wall formation|cell wall synthesis|cell wall anabolism|cell envelope biosynthetic process biological_process owl:Class
GO:0051286 biolink:NamedThing cell tip The region at the end of the longest axis of a cylindrical or elongated cell. got7fsn_ti cell end Note that this term differs from 'cell pole ; GO:0060187' in that it is applicable to the thin ends of elongated cells, such as the ends of axons or dendrites. cellular_component owl:Class
GO:0060187 biolink:NamedThing cell pole Either of two different areas at opposite ends of an axis of a cell. got7fsn_ti Note that this term differs from 'cell tip ; GO:0051286' in that it is applicable to a broad range of cell shapes including spherical and cuboidal. cellular_component owl:Class
GO:0044300 biolink:NamedThing cerebellar mossy fiber An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations. got7fsn_ti cerebellar mossy fibre jl 2010-02-05T11:16:40Z NIF_Subcellular:nlx_subcell_20090209 cellular_component owl:Class
GO:0004481 biolink:NamedThing methylene-fatty-acyl-phospholipid synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid. got7fsn_ti S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)|unsaturated-phospholipid methyltransferase activity|cyclopropane synthetase activity EC:2.1.1.16|MetaCyc:2.1.1.16-RXN|RHEA:17549 molecular_function owl:Class
GO:0007059 biolink:NamedThing chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. got7fsn_ti chromosome transmission|chromosome division Wikipedia:Chromosome_segregation biological_process owl:Class
GO:0015325 biolink:NamedThing acetyl-CoA:CoA antiporter activity Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out). got7fsn_ti molecular_function owl:Class
GO:0008521 biolink:NamedThing acetyl-CoA transmembrane transporter activity Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. got7fsn_ti acetyl-CoA transporter activity Reactome:R-HSA-5649742|Reactome:R-HSA-727759 molecular_function owl:Class
GO:0042722 biolink:NamedThing alpha-beta T cell activation by superantigen The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region. got7fsn_ti alpha-beta T-lymphocyte activation by superantigen|alpha-beta T lymphocyte activation by superantigen|alpha-beta T-cell activation by superantigen biological_process owl:Class
GO:0046631 biolink:NamedThing alpha-beta T cell activation The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti alpha-beta T-cell activation|alpha-beta T lymphocyte activation|alpha-beta T-lymphocyte activation biological_process owl:Class
GO:0048393 biolink:NamedThing intermediate mesodermal cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an intermediate mesoderm cell. got7fsn_ti intermediate mesoderm cell fate commitment biological_process owl:Class
GO:0015054 biolink:NamedThing gastrin receptor activity Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. got7fsn_ti cholecystokinin-B receptor activity molecular_function owl:Class
GO:0034207 biolink:NamedThing steroid acetylation The addition of an acetyl group to a steroid molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti biological_process owl:Class
GO:1990192 biolink:NamedThing collecting lymphatic vessel constriction A decrease in the diameter of collecting lymphatic vessels. got7fsn_ti lymphatic vessel myogenic constriction sl 2013-09-12T14:46:05Z biological_process owl:Class
GO:1990186 biolink:NamedThing regulation of lymphatic vessel size Any process that modulates the size of lymphatic vessels. got7fsn_ti regulation of collecting lymphatic vessel size sl 2013-09-11T15:41:16Z biological_process owl:Class
GO:0016028 biolink:NamedThing rhabdomere The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction. got7fsn_ti cellular_component owl:Class
GO:0048475 biolink:NamedThing coated membrane A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes. got7fsn_ti cellular_component owl:Class
GO:0034628 biolink:NamedThing 'de novo' NAD biosynthetic process from aspartate The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. got7fsn_ti de novo NAD biosynthetic process from aspartate biological_process owl:Class
GO:0034627 biolink:NamedThing 'de novo' NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan or aspartate from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. got7fsn_ti de novo NAD biosynthetic process biological_process owl:Class
GO:0018031 biolink:NamedThing peptidyl-lysine N6-palmitoyltransferase activity Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule. got7fsn_ti EC:2.3.1.- molecular_function owl:Class
GO:0018006 biolink:NamedThing N-terminal protein amino acid glucuronylation The glucuronylation of the N-terminal amino acid of proteins. got7fsn_ti biological_process owl:Class
GO:0050659 biolink:NamedThing N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. got7fsn_ti GalNAc4S-6ST|3'-phosphoadenylyl-sulfate:dermatan 6'-sulfotransferase activity|N-acetylgalactosamine 4-sulfate 6-O-sulphotransferase activity Consider instead annotating to the individual reactions: 'chondroitin 6-sulfotransferase activity ; GO:0008459' and 'dermatan 6-sulfotransferase activity ; GO:0036443'. KEGG_REACTION:R02181|Reactome:R-HSA-2018659|MetaCyc:RXN-7954|MetaCyc:RXN-7953|EC:2.8.2.33|KEGG_REACTION:R07288 molecular_function owl:Class
GO:0031748 biolink:NamedThing D1 dopamine receptor binding Binding to a D1 dopamine receptor. got7fsn_ti D1A dopamine receptor binding|D1 dopamine receptor ligand molecular_function owl:Class
GO:0016907 biolink:NamedThing G protein-coupled acetylcholine receptor activity Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti metabotropic acetylcholine receptor activity|G protein coupled acetylcholine receptor activity|muscarinic acetylcholine receptor activity|acetylcholine receptor activity, G-protein coupled|G-protein coupled acetylcholine receptor activity GO:0004981 molecular_function owl:Class
GO:0015464 biolink:NamedThing acetylcholine receptor activity Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'. molecular_function owl:Class
GO:0033788 biolink:NamedThing leucoanthocyanidin reductase activity Catalysis of the reaction: (2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+. got7fsn_ti (2R,3S)-catechin:NADP+ 4-oxidoreductase activity|leucocyanidin reductase activity RHEA:10616|EC:1.17.1.3|MetaCyc:RXN-1484 molecular_function owl:Class
GO:0106240 biolink:NamedThing labd-13Z-ene-9,15,16-triol synthase activity Catalysis of the reaction:O2 + peregrinol + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + labd-13Z-ene-9,15,16-triol + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti hjd 2019-12-19T17:43:00Z RHEA:62192 molecular_function owl:Class
GO:0004051 biolink:NamedThing arachidonate 5-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. got7fsn_ti C-5-lipoxygenase activity|arachidonic acid 5-lipoxygenase activity|arachidonate:oxygen 5-oxidoreductase activity|leukotriene-A(4) synthase activity|5Delta-lipoxygenase activity|arachidonic 5-lipoxygenase activity|leukotriene A4 synthase|5-lipoxygenase activity|5-delta-lipoxygenase activity|delta5-lipoxygenase activity|leukotriene-A4 synthase activity|delta(5)-lipoxygenase activity|LTA synthase activity Reactome:R-HSA-9018863|Reactome:R-HSA-9026405|Reactome:R-HSA-9018894|Reactome:R-HSA-9020264|Reactome:R-HSA-9020251|Reactome:R-HSA-9020282|Reactome:R-HSA-9025999|Reactome:R-HSA-9020278|RHEA:32307|Reactome:R-HSA-266051|Reactome:R-HSA-9027624|MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN|Reactome:R-HSA-9025996|Reactome:R-HSA-9020256|Reactome:R-HSA-9025995|Reactome:R-HSA-265296|Reactome:R-HSA-9026005|Reactome:R-HSA-9018859|Reactome:R-HSA-9027628|Reactome:R-HSA-9018858|Reactome:R-HSA-9020259|Reactome:R-HSA-9020277|EC:1.13.11.34|Reactome:R-HSA-9024997|Reactome:R-HSA-9027633|Reactome:R-HSA-9020255 molecular_function owl:Class
GO:0050159 biolink:NamedThing orsellinate decarboxylase activity Catalysis of the reaction: o-orsellinate + H(+) = CO(2) + orcinol. got7fsn_ti orsellinate carboxy-lyase (orcinol-forming)|orsellinate carboxy-lyase activity MetaCyc:ORSELLINATE-DECARBOXYLASE-RXN|KEGG_REACTION:R02831|RHEA:16733|EC:4.1.1.58 molecular_function owl:Class
GO:0072094 biolink:NamedThing metanephric renal vesicle induction Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the metanephric renal vesicle. got7fsn_ti positive regulation of metanephros formation mah 2010-02-10T01:23:20Z biological_process owl:Class
GO:0072216 biolink:NamedThing positive regulation of metanephros development Any process that increases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti mah 2010-03-18T01:40:12Z biological_process owl:Class
GO:0016071 biolink:NamedThing mRNA metabolic process The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. got7fsn_ti mRNA metabolism biological_process owl:Class
GO:0036009 biolink:NamedThing protein-glutamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine. got7fsn_ti bf 2011-10-03T02:27:05Z Reactome:R-HSA-6800138 molecular_function owl:Class
GO:0015834 biolink:NamedThing peptidoglycan-associated peptide transport The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains. got7fsn_ti muropeptide transport|murein peptide transport|peptidoglycan peptide transport biological_process owl:Class
GO:0015833 biolink:NamedThing peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0016824 biolink:NamedThing hydrolase activity, acting on acid halide bonds Catalysis of the hydrolysis of any acid halide bond. got7fsn_ti EC:3.8.-.- molecular_function owl:Class
GO:0045814 biolink:NamedThing negative regulation of gene expression, epigenetic Any epigenetic process that stops, prevents or reduces the rate of gene expression. got7fsn_ti downregulation of gene expression, epigenetic|down-regulation of gene expression, epigenetic|down regulation of gene expression, epigenetic|inhibition of gene expression, epigenetic biological_process owl:Class
GO:0022804 biolink:NamedThing active transmembrane transporter activity Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. got7fsn_ti pump activity|carrier activity|permease activity|active carrier activity molecular_function owl:Class
GO:0050144 biolink:NamedThing nucleoside deoxyribosyltransferase activity Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1. got7fsn_ti nucleoside:purine(pyrimidine) deoxy-D-ribosyltransferase activity|trans-deoxyribosylase activity|nucleoside deoxyribosyltransferase II [purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase]|nucleoside trans-N-deoxyribosylase activity|deoxyribose transferase activity|trans-N-deoxyribosylase activity|purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyl transferase activity|trans-N-glycosidase activity|nucleoside deoxyribosyltransferase I (purine nucleoside:purine deoxyribosyltransferase: strictly specific for transfer between purine bases) MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN|EC:2.4.2.6 molecular_function owl:Class
GO:0010180 biolink:NamedThing thioglucosidase binding Binding to a thioglucosidase enzyme. got7fsn_ti myrosinase binding molecular_function owl:Class
GO:0120026 biolink:NamedThing host cell uropod A host cell membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively. got7fsn_ti host cell uropodium krc 2017-03-22T21:33:31Z cellular_component owl:Class
GO:0034842 biolink:NamedThing thiophene-2-carboxylate-CoA ligase activity Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi. got7fsn_ti UM-BBD_reactionID:r1234 molecular_function owl:Class
GO:0008235 biolink:NamedThing metalloexopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. got7fsn_ti molecular_function owl:Class
GO:0039724 biolink:NamedThing suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E). got7fsn_ti suppression by virus of host IKBKE activity|inhibition of host IKBKE by virus https://github.com/geneontology/go-ontology/issues/21985 bf 2014-01-06T12:15:03Z biological_process owl:Class
GO:0039537 biolink:NamedThing suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. This is a mechanism by which the virus evades the host innate immune response. got7fsn_ti suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signalling pathway|suppression by virus of host RIG-I/MDA5 signaling pathway|suppression by virus of host RIG-like receptor signaling pathway|suppression by virus of host RIG-like helicase signaling pathway|suppression by virus of host cytoplasmic pattern recognition receptor signaling pathway in response to virus|suppression by virus of host RIG-I-like receptor (RLR) signaling pathway|suppression by virus of host RLR signaling pathway bf 2012-01-03T11:47:05Z biological_process owl:Class
GO:0050607 biolink:NamedThing mycothiol-dependent formaldehyde dehydrogenase activity Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+. got7fsn_ti NAD/factor-dependent formaldehyde dehydrogenase activity|formaldehyde:NAD+ oxidoreductase (mycothiol-formylating) EC:1.1.1.306|MetaCyc:1.2.1.66-RXN|RHEA:28502 molecular_function owl:Class
GO:1902362 biolink:NamedThing melanocyte apoptotic process Any apoptotic process in a melanocyte, the main structural component of the epidermis. got7fsn_ti melanophore apoptosis|melanophore apoptotic process|melanocyte apoptosis pr 2013-08-15T16:35:45Z biological_process owl:Class
GO:0044686 biolink:NamedThing cysteate synthase activity Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-. got7fsn_ti jl 2012-08-15T14:16:05Z RHEA:26486|MetaCyc:RXN-11108|EC:2.5.1.76 molecular_function owl:Class
GO:0036090 biolink:NamedThing cleavage furrow ingression Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed. got7fsn_ti cleavage furrow contraction Consider also annotating to 'contractile ring contraction involved in cell cycle cytokinesis ; GO:0000916'. bf 2012-01-10T02:46:05Z biological_process owl:Class
GO:0099024 biolink:NamedThing plasma membrane invagination An infolding of the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0072375 biolink:NamedThing medium-term memory The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster). got7fsn_ti MTM|middle-term memory mah 2010-11-22T11:26:54Z biological_process owl:Class
GO:0007613 biolink:NamedThing memory The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). got7fsn_ti Wikipedia:Memory biological_process owl:Class
GO:0030583 biolink:NamedThing myxococcal fruiting body development The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure. got7fsn_ti fruiting body development in response to starvation|fruiting body development in cellular response to starvation For example, as seen in myxobacterium. It is not intended to describe fruiting body development as is Dictyostelium. GO:0055084 biological_process owl:Class
GO:0043828 biolink:NamedThing tRNA 2-selenouridine synthase activity Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA). got7fsn_ti RHEA:42716|MetaCyc:RXN0-2281|EC:2.9.1.3 molecular_function owl:Class
GO:0018357 biolink:NamedThing protein-phycourobilin linkage via phycourobilin-bis-L-cysteine The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine. got7fsn_ti GO:0018383 RESID:AA0260 biological_process owl:Class
GO:0017010 biolink:NamedThing protein-phycourobilin linkage The linkage of the chromophore phycourobilin to phycoerythrins. got7fsn_ti RESID:AA0260 biological_process owl:Class
GO:0047478 biolink:NamedThing aspartate-ammonia ligase (ADP-forming) activity Catalysis of the reaction: L-aspartate + ATP + NH(4)(+) = L-asparagine + ADP + 2 H(+) + phosphate. got7fsn_ti asparagine synthetase (adenosine diphosphate-forming)|asparagine synthetase (ADP-forming) activity|L-aspartate:ammonia ligase (ADP-forming) MetaCyc:6.3.1.4-RXN|EC:6.3.1.4|RHEA:14197|KEGG_REACTION:R00482 molecular_function owl:Class
GO:0061754 biolink:NamedThing negative regulation of circulating fibrinogen levels Any process that reduces the quantity of fibrinogen circulating in the bloodstream. got7fsn_ti dph 2016-02-29T16:19:09Z biological_process owl:Class
GO:0098529 biolink:NamedThing neuromuscular junction development, skeletal muscle fiber A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber. got7fsn_ti biological_process owl:Class
GO:0007528 biolink:NamedThing neuromuscular junction development A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction. got7fsn_ti neuromuscular junction organization|neuromuscular junction stability|NMJ stability biological_process owl:Class
GO:0042467 biolink:NamedThing orthokinesis The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased. got7fsn_ti biological_process owl:Class
GO:0004335 biolink:NamedThing galactokinase activity Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+). got7fsn_ti ATP:D-galactose 1-phosphotransferase activity|galactokinase (phosphorylating)|ATP:D-galactose-1-phosphotransferase activity KEGG_REACTION:R01092|MetaCyc:GALACTOKIN-RXN|EC:2.7.1.6|RHEA:13553|Reactome:R-HSA-70355|Reactome:R-HSA-5610026 molecular_function owl:Class
GO:0048723 biolink:NamedThing clypeus development The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head. got7fsn_ti biological_process owl:Class
GO:0005590 biolink:NamedThing collagen type VII trimer A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin. got7fsn_ti cellular_component owl:Class
GO:0030934 biolink:NamedThing anchoring collagen complex Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures. got7fsn_ti connecting collagen|linking collagen cellular_component owl:Class
GO:0018152 biolink:NamedThing peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link. got7fsn_ti RESID:AA0270 biological_process owl:Class
GO:0018151 biolink:NamedThing peptide cross-linking via L-histidyl-L-tyrosine The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link. got7fsn_ti biological_process owl:Class
GO:0042208 biolink:NamedThing propylene catabolic process The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. got7fsn_ti propylene catabolism|propylene breakdown|propylene degradation UM-BBD_pathwayID:pro biological_process owl:Class
GO:0047707 biolink:NamedThing biotin-CoA ligase activity Catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA. got7fsn_ti biotinyl-CoA synthetase activity|biotin CoA synthetase activity|biotin:CoA ligase (AMP-forming)|biotinyl coenzyme A synthetase activity EC:6.2.1.11|MetaCyc:BIOTIN--COA-LIGASE-RXN|RHEA:19681 molecular_function owl:Class
GO:0102818 biolink:NamedThing lycopene cleavage oxygenase activity Catalysis of the reaction: lycopene + 2 O2 <=> 2 sulcatone + bixin aldehyde. got7fsn_ti MetaCyc:RXN-8236 molecular_function owl:Class
GO:0102871 biolink:NamedThing 1-16:0-2-18:1-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-16:0-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-palmitoyl-2-linoleoyl-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8360|EC:1.14.19.22 molecular_function owl:Class
GO:0006699 biolink:NamedThing bile acid biosynthetic process The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile. got7fsn_ti bile acid anabolism|bile acid biosynthesis|bile acid formation|bile acid synthesis biological_process owl:Class
GO:0008206 biolink:NamedThing bile acid metabolic process The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. got7fsn_ti bile acid metabolism biological_process owl:Class
GO:0010648 biolink:NamedThing negative regulation of cell communication Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti biological_process owl:Class
GO:0080007 biolink:NamedThing S-nitrosoglutathione reductase activity Catalysis of the reaction: glutathione N-hydroxysulfenamide + NADH + H+ = S-nitrosoglutathione + NAD+. got7fsn_ti MetaCyc:RXN-10742 molecular_function owl:Class
GO:0071475 biolink:NamedThing cellular hyperosmotic salinity response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. got7fsn_ti cellular response to hyperosmotic salt stress mah 2009-12-18T11:52:06Z biological_process owl:Class
GO:0071474 biolink:NamedThing cellular hyperosmotic response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. got7fsn_ti cellular HOG response|cellular hypertonic response|cellular response to hypertonicity mah 2009-12-18T11:51:36Z biological_process owl:Class
GO:0090655 biolink:NamedThing double-stranded/single-stranded junction telomeric DNA binding Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang. got7fsn_ti tb 2015-07-02T11:33:39Z molecular_function owl:Class
GO:0042162 biolink:NamedThing telomeric DNA binding Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. got7fsn_ti telomere binding|telomeric repeat binding molecular_function owl:Class
GO:0051755 biolink:NamedThing meiotic sister chromatid arm separation The cell cycle process in which sister chromatid arms are physically detached from each other during meiosis. got7fsn_ti biological_process owl:Class
GO:0001967 biolink:NamedThing suckling behavior Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. got7fsn_ti nursing behavior biological_process owl:Class
GO:0007631 biolink:NamedThing feeding behavior Behavior associated with the intake of food. got7fsn_ti injection of substance into other organism during feeding on blood of other organism|feeding from xylem of other organism|behavioural response to food|feeding from plant phloem|feeding from phloem of other organism|feeding behaviour|taking of blood meal|feeding on blood of other organism|behavioral response to food|hematophagy|feeding from tissue of other organism|eating|feeding from vascular tissue of another organism|feeding on or from other organism|feeding on plant sap https://github.com/geneontology/go-ontology/issues/18547 See also the biological process term 'behavior ; GO:0007610'. jl 2011-10-27T03:53:33Z GO:0044369|GO:0044367|GO:0044366|GO:0044370|GO:0044371|GO:0044368|GO:0044372 Wikipedia:List_of_feeding_behaviours biological_process owl:Class
GO:0005652 biolink:NamedThing nuclear lamina The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane. got7fsn_ti NIF_Subcellular:sao1455996588|Wikipedia:Nuclear_lamina cellular_component owl:Class
GO:0006238 biolink:NamedThing CMP salvage Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis. got7fsn_ti cytidine monophosphate salvage biological_process owl:Class
GO:0009224 biolink:NamedThing CMP biosynthetic process The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate. got7fsn_ti CMP formation|CMP anabolism|CMP synthesis|CMP biosynthesis biological_process owl:Class
GO:0043667 biolink:NamedThing pollen wall The wall surrounding a mature pollen grain; a multilayered structure consisting of a pectocellulosic intine surrounded by a sporopollenin-based exine, which itself contains two layers, the inner nexine and the outer sexine. got7fsn_ti microspore wall cellular_component owl:Class
GO:0097608 biolink:NamedThing transverse flagellum A motile cilium found in dinoflagellates. It coils around the cell and provides the forward thrust for motility. It is often contained in a furrow called the cingulum, and emerges from a flagellar pore located in the cingulum. got7fsn_ti transverse cilium Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate. pr 2014-06-09T11:14:37Z cellular_component owl:Class
GO:0002194 biolink:NamedThing hepatocyte cell migration The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes. got7fsn_ti hjd 2011-08-30T04:27:39Z biological_process owl:Class
GO:1900571 biolink:NamedThing diorcinol catabolic process The chemical reactions and pathways resulting in the breakdown of diorcinol. got7fsn_ti diorcinol breakdown|diorcinol degradation|diorcinol catabolism di 2012-05-15T06:35:22Z biological_process owl:Class
GO:0008345 biolink:NamedThing larval locomotory behavior Locomotory behavior in a larval (immature) organism. got7fsn_ti larval locomotory behaviour See also the biological process term 'locomotory behavior ; GO:0007626'. biological_process owl:Class
GO:0007626 biolink:NamedThing locomotory behavior The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. got7fsn_ti locomotory behaviour|locomotion in response to stimulus|behavior via locomotion|locomotory behavioural response to stimulus|locomotory behavioral response to stimulus biological_process owl:Class
GO:0018287 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide RESID:AA0139 biological_process owl:Class
GO:0018855 biolink:NamedThing 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA. got7fsn_ti RHEA:33419|UM-BBD_reactionID:r0429|EC:6.2.1.38 molecular_function owl:Class
GO:0051631 biolink:NamedThing regulation of acetylcholine uptake Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter acetylcholine into a cell. got7fsn_ti regulation of acetylcholine import biological_process owl:Class
GO:0044619 biolink:NamedThing positive regulation of relaxation of uterine smooth muscle in other organism The process in which an organism increases the extent of relaxation of smooth muscle in the uterus of a second organism. got7fsn_ti jl 2012-07-04T02:51:26Z biological_process owl:Class
GO:1900721 biolink:NamedThing positive regulation of uterine smooth muscle relaxation Any process that activates or increases the frequency, rate or extent of uterine smooth muscle relaxation. got7fsn_ti up-regulation of uterine smooth muscle relaxation|positive regulation of smooth muscle relaxation of the uterus|up regulation of smooth muscle relaxation of the uterus|activation of smooth muscle relaxation of the uterus|up-regulation of smooth muscle relaxation of the uterus|up regulation of uterine smooth muscle relaxation|upregulation of uterine smooth muscle relaxation|activation of uterine smooth muscle relaxation|upregulation of smooth muscle relaxation of the uterus jl 2012-05-24T03:12:57Z biological_process owl:Class
GO:0031523 biolink:NamedThing Myb complex A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression. got7fsn_ti Myeloblastosis proto-oncogene protein complex cellular_component owl:Class
GO:0002029 biolink:NamedThing desensitization of G protein-coupled receptor signaling pathway The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway. got7fsn_ti desensitization of G-protein coupled receptor protein signaling pathway|desensitisation of G-protein coupled receptor protein signalling pathway biological_process owl:Class
GO:0045744 biolink:NamedThing negative regulation of G protein-coupled receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway. got7fsn_ti negative regulation of G-protein coupled receptor protein signalling pathway|downregulation of G-protein coupled receptor protein signaling pathway|negative regulation of G-protein-coupled receptor protein signalling pathway|inhibition of G-protein coupled receptor protein signaling pathway|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of GPCR protein signaling pathway|negative regulation of GPCR protein signalling pathway|down regulation of G-protein coupled receptor protein signaling pathway|negative regulation of G protein coupled receptor protein signaling pathway|down-regulation of G-protein coupled receptor protein signaling pathway|negative regulation of G protein coupled receptor protein signalling pathway biological_process owl:Class
GO:0019758 biolink:NamedThing glycosinolate biosynthetic process The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. got7fsn_ti glycosinolate biosynthesis|glycosinolate synthesis|glycosinolate formation|glycosinolate anabolism biological_process owl:Class
GO:1990697 biolink:NamedThing protein depalmitoleylation The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein. got7fsn_ti sp 2015-03-13T08:55:31Z biological_process owl:Class
GO:0042159 biolink:NamedThing lipoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. got7fsn_ti lipoprotein degradation|lipoprotein breakdown|lipoprotein catabolism biological_process owl:Class
GO:0102746 biolink:NamedThing tetrahydrogeranylgeranyl-PP reductase activity Catalysis of the reaction: H+ + tetrahydrogeranylgeranyl-PP + NADPH = (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + NADP. got7fsn_ti MetaCyc:RXN-7660 molecular_function owl:Class
GO:0010088 biolink:NamedThing phloem development The formation of the principal food-conducting tissue of a vascular plant. got7fsn_ti phloem histogenesis biological_process owl:Class
GO:0006562 biolink:NamedThing proline catabolic process The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. got7fsn_ti proline breakdown|proline degradation|proline catabolism biological_process owl:Class
GO:0070826 biolink:NamedThing paraferritin complex A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme. got7fsn_ti mah 2009-07-23T03:05:08Z cellular_component owl:Class
GO:0030727 biolink:NamedThing germarium-derived female germ-line cyst formation Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster. got7fsn_ti germarium-derived female germline cyst formation biological_process owl:Class
GO:0048135 biolink:NamedThing female germ-line cyst formation Formation of a group of interconnected cells derived from a single female gonial founder cell. got7fsn_ti female germline cyst formation biological_process owl:Class
GO:0003272 biolink:NamedThing endocardial cushion formation The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. got7fsn_ti dph 2009-10-20T08:53:19Z biological_process owl:Class
GO:0044623 biolink:NamedThing positive regulation of cell migration in other organism Any process that activates or increases the frequency, rate or extent of cell migration in a second organism. got7fsn_ti jl 2012-07-04T04:44:59Z biological_process owl:Class
GO:0043564 biolink:NamedThing Ku70:Ku80 complex Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK. got7fsn_ti Ku70:Ku80 heterodimer cellular_component owl:Class
GO:0034015 biolink:NamedThing L-ribulose-5-phosphate 3-epimerase activity Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate. got7fsn_ti UlaE|SgaU|L-xylulose 5-phosphate 3-epimerase activity EC:5.1.3.22|MetaCyc:LXULRU5P-RXN|RHEA:18497 molecular_function owl:Class
GO:0005956 biolink:NamedThing protein kinase CK2 complex A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. got7fsn_ti casein kinase II complex Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. cellular_component owl:Class
GO:0106262 biolink:NamedThing 1-acylglycerophosphoethanolamine O-acyltransferase activity Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA. got7fsn_ti hjd 2020-05-18T15:09:57Z RHEA:32995 molecular_function owl:Class
GO:0045317 biolink:NamedThing equator specification The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves. got7fsn_ti biological_process owl:Class
GO:0051965 biolink:NamedThing positive regulation of synapse assembly Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. got7fsn_ti positive regulation of synaptogenesis|activation of synapse assembly|upregulation of synapse assembly|positive regulation of synapse biogenesis|up-regulation of synapse assembly|up regulation of synapse assembly|stimulation of synapse assembly biological_process owl:Class
GO:0044089 biolink:NamedThing positive regulation of cellular component biogenesis Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. got7fsn_ti biological_process owl:Class
GO:0102724 biolink:NamedThing UDP-glucose:curcumin monoglucoside glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + curcumin monoglucoside = H+ + curcumin diglucoside + UDP. got7fsn_ti MetaCyc:RXN-7063 molecular_function owl:Class
GO:0046921 biolink:NamedThing alpha-(1->6)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->6) linkage. got7fsn_ti alpha-(1,6)-fucosyltransferase activity|alpha(1,6)-fucosyltransferase activity|alpha-1,6-fucosyltransferase activity molecular_function owl:Class
GO:0008417 biolink:NamedThing fucosyltransferase activity Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. got7fsn_ti Reactome:R-HSA-9033949 molecular_function owl:Class
GO:0032801 biolink:NamedThing receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. got7fsn_ti receptor degradation|receptor breakdown|receptor catabolism biological_process owl:Class
GO:0043112 biolink:NamedThing receptor metabolic process The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. got7fsn_ti receptor metabolism biological_process owl:Class
GO:0075275 biolink:NamedThing telium development The process that leads to the development of a telium, which is a teliospore-bearing sorus of the rust fungi. got7fsn_ti biological_process owl:Class
GO:0047105 biolink:NamedThing 4-trimethylammoniobutyraldehyde dehydrogenase activity Catalysis of the reaction: NAD+ + 4-trimethylammoniobutanal = NADH + 4-trimethylammoniobutanoate. got7fsn_ti 4-trimethylammoniobutanal:NAD+ 1-oxidoreductase activity|4-N-trimethylaminobutyraldehyde dehydrogenase activity|4-trimethylaminobutyraldehyde dehydrogenase activity MetaCyc:1.2.1.47-RXN|RHEA:17985|EC:1.2.1.47 molecular_function owl:Class
GO:0004827 biolink:NamedThing proline-tRNA ligase activity Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). got7fsn_ti prolinyl-tRNA ligase activity|proline translase activity|prolyl-s-RNA synthetase activity|prolyl-transferRNA synthetase activity|prolyl-transfer ribonucleic acid synthetase activity|prolyl-tRNA synthetase activity|L-proline:tRNAPro ligase (AMP-forming)|prolyl-transfer ribonucleate synthetase activity MetaCyc:PROLINE--TRNA-LIGASE-RXN|EC:6.1.1.15|Reactome:R-HSA-380198|Reactome:R-HSA-379865|RHEA:14305 molecular_function owl:Class
GO:0004812 biolink:NamedThing aminoacyl-tRNA ligase activity Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. got7fsn_ti ligase activity, forming aminoacyl-tRNA and related compounds|aminoacyl-tRNA synthetase auxiliary protein activity|aminoacyl-tRNA synthetase activity Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. GO:0017100|GO:0016876 EC:6.1.1.- molecular_function owl:Class
GO:0060827 biolink:NamedThing regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Any process that modulates the rate, frequency, or extent of Wnt signaling through beta-catenin that results in the formation of the neural plate anterior/posterior pattern. got7fsn_ti regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern formation|regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation|regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation dph 2009-08-11T01:48:52Z biological_process owl:Class
GO:0050176 biolink:NamedThing phenylalanine N-acetyltransferase activity Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+). got7fsn_ti acetyl-CoA-L-phenylalanine alpha-N-acetyltransferase activity|acetyl-CoA:L-phenylalanine N-acetyltransferase activity EC:2.3.1.53|KEGG_REACTION:R00693|RHEA:17801|MetaCyc:PHENYLALANINE-N-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:1990196 biolink:NamedThing MacAB-TolC complex The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC. got7fsn_ti macrolide transporter MacAB-TolC complex bhm 2013-09-23T11:29:28Z cellular_component owl:Class
GO:1990195 biolink:NamedThing macrolide transmembrane transporter complex A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes. got7fsn_ti AcrAB-TolC complex|macrolide transporter complex|MacAB-TolC complex|macrolide transporter bhm 2013-09-23T11:22:26Z cellular_component owl:Class
GO:0052742 biolink:NamedThing phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. got7fsn_ti ai 2011-09-14T01:21:47Z molecular_function owl:Class
GO:0070096 biolink:NamedThing mitochondrial outer membrane translocase complex assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial outer membrane translocase complex. got7fsn_ti mitochondrion outer membrane translocase complex assembly|TOM complex assembly biological_process owl:Class
GO:0046230 biolink:NamedThing 2-aminobenzenesulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines. got7fsn_ti 2-aminobenzenesulfonate catabolism|2-aminobenzenesulfonate degradation|2-aminobenzenesulphonate catabolism|2-aminobenzenesulphonate catabolic process|2-aminobenzenesulfonate breakdown biological_process owl:Class
GO:0009310 biolink:NamedThing amine catabolic process The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. got7fsn_ti amine catabolism|amine breakdown|amine degradation biological_process owl:Class
GO:0046997 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a flavin. got7fsn_ti EC:1.5.8.- molecular_function owl:Class
GO:0000735 biolink:NamedThing removal of nonhomologous ends The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur. got7fsn_ti biological_process owl:Class
GO:0000376 biolink:NamedThing RNA splicing, via transesterification reactions with guanosine as nucleophile Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile. got7fsn_ti biological_process owl:Class
GO:0000375 biolink:NamedThing RNA splicing, via transesterification reactions Splicing of RNA via a series of two transesterification reactions. got7fsn_ti spliceosomal catalysis|RNA splicing factor activity, transesterification mechanism|pre-mRNA splicing factor activity Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. GO:0031202|GO:0000385 biological_process owl:Class
GO:0043961 biolink:NamedThing succinyl-CoA:(R)-citramalate CoA-transferase activity Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA. got7fsn_ti L-carnitine dehydratase/bile acid-inducible protein F|succinyl-CoA:R-citramalate CoA transferase|succinyl-CoA:(R)-citramalate CoA transferase activity MetaCyc:RXN-8966|EC:2.8.3.20|RHEA:38279 molecular_function owl:Class
GO:0008713 biolink:NamedThing ADP-heptose-lipopolysaccharide heptosyltransferase activity Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. got7fsn_ti ADP-heptose:LPS heptosyltransferase activity RHEA:28538|MetaCyc:RXN0-5061 molecular_function owl:Class
GO:0008920 biolink:NamedThing lipopolysaccharide heptosyltransferase activity Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+. got7fsn_ti LPS heptosyltransferase activity molecular_function owl:Class
GO:0034290 biolink:NamedThing holin activity A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly or indirectly allows murein hydrolyases to access their cell wall substrate. got7fsn_ti molecular_function owl:Class
GO:0090015 biolink:NamedThing positive regulation of leaflet formation by auxin mediated signaling pathway Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin. got7fsn_ti positive regulation of leaflet formation by auxin mediated signalling pathway tb 2009-07-29T11:18:45Z biological_process owl:Class
GO:0009734 biolink:NamedThing auxin-activated signaling pathway A series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. got7fsn_ti auxin mediated signalling|auxin signal transduction|auxin mediated signaling pathway|auxin-regulated transcription|auxin signaling biological_process owl:Class
GO:0051652 biolink:NamedThing maintenance of chromosome location Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of chromosome localization biological_process owl:Class
GO:0051657 biolink:NamedThing maintenance of organelle location Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of organelle localization biological_process owl:Class
GO:0022010 biolink:NamedThing central nervous system myelination The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. got7fsn_ti myelination in central nervous system biological_process owl:Class
GO:0032291 biolink:NamedThing axon ensheathment in central nervous system The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. got7fsn_ti ensheathment of axons in central nervous system biological_process owl:Class
GO:0061585 biolink:NamedThing hypocretin secretion, neurotransmission The controlled release of a peptide from a cell or a tissue in which the peptide acts as a neurotransmitter. got7fsn_ti orexin secretion, neurotransmission dph 2013-12-26T10:09:37Z biological_process owl:Class
GO:0003872 biolink:NamedThing 6-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate. got7fsn_ti 6-phosphofructokinase reduction|fructose 6-phosphate kinase activity|nucleotide triphosphate-dependent phosphofructokinase activity|phosphohexokinase activity|D-fructose-6-phosphate 1-phosphotransferase activity|phospho-1,6-fructokinase activity|ATP-dependent phosphofructokinase activity|PFK|phosphofructokinase (phosphorylating)|ATP:D-fructose-6-phosphate 1-phosphotransferase activity|phosphofructokinase I activity|6-phosphofructose 1-kinase activity|fructose 6-phosphokinase activity MetaCyc:6PFRUCTPHOS-RXN|RHEA:16109|Reactome:R-HSA-70467|EC:2.7.1.11 molecular_function owl:Class
GO:0008443 biolink:NamedThing phosphofructokinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. got7fsn_ti molecular_function owl:Class
GO:0042605 biolink:NamedThing peptide antigen binding Binding to an antigen peptide. got7fsn_ti exogenous peptide antigen binding|endogenous peptide antigen binding Note that this term can be used to describe the binding of a peptide to an MHC molecule. GO:0042607|GO:0042606 molecular_function owl:Class
GO:0003823 biolink:NamedThing antigen binding Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. got7fsn_ti B cell receptor activity|immunoglobulin|antibody|opsonin activity molecular_function owl:Class
GO:0047290 biolink:NamedThing (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity Catalysis of the reaction: alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R + CMP-N-acetyl-beta-neuraminate = alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-D-galactosaminyl-R + CMP. got7fsn_ti (alpha-N-acetylneuraminyl-2,3-alpha-galactosyl-1,3)-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity|SIAT7|CMP-N-acetylneuraminate:(alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3)-N-acetyl-D-galactosaminide alpha-2,6-N-acetylneuraminyl-transferase activity|(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity|sialyltransferase 3C activity|alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase activity|ST6GALNAC activity|cytidine monophosphoacetylneuraminate-(alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide-alpha-2,6-sialyltransferase activity|sialyltransferase 7D activity|NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase activity Reactome:R-HSA-981809|MetaCyc:2.4.99.7-RXN|EC:2.4.99.7|RHEA:53896|KEGG_REACTION:R04635 molecular_function owl:Class
GO:0008828 biolink:NamedThing dATP pyrophosphohydrolase activity Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate. got7fsn_ti 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity|2-hydroxy-ATP pyrophosphatase activity|2-hydroxy-(d)ATP pyrophosphatase activity|2-hydroxy-adenosine triphosphate pyrophosphatase activity https://github.com/geneontology/go-ontology/issues/20656 jl 2012-10-18T13:22:38Z GO:0044713|GO:0044714 EC:3.6.1.56|Reactome:R-HSA-2395818|Reactome:R-HSA-2395872|MetaCyc:RXN0-384 molecular_function owl:Class
GO:0097227 biolink:NamedThing sperm annulus The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity. got7fsn_ti pr 2012-01-25T01:26:17Z cellular_component owl:Class
GO:0038063 biolink:NamedThing collagen-activated tyrosine kinase receptor signaling pathway A series of molecular signals initiated by the binding of collagen to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti collagen-activated RTK signaling pathway|DDR signaling pathway|discoidin domain receptor signaling pathway|collagen-activated tyrosine kinase receptor signalling pathway bf 2012-01-18T01:43:20Z biological_process owl:Class
GO:0038065 biolink:NamedThing collagen-activated signaling pathway A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti collagen-activated signalling pathway bf 2012-01-18T01:57:37Z biological_process owl:Class
GO:0000366 biolink:NamedThing intergenic mRNA trans splicing The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing. got7fsn_ti intergenic nuclear mRNA trans splicing biological_process owl:Class
GO:0000365 biolink:NamedThing mRNA trans splicing, via spliceosome The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. got7fsn_ti nuclear mRNA trans splicing, via U2-type spliceosome|nuclear mRNA trans splicing, via spliceosome biological_process owl:Class
GO:0044489 biolink:NamedThing negative regulation of voltage-gated sodium channel activity in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism. got7fsn_ti jl 2012-02-01T12:21:02Z biological_process owl:Class
GO:0045914 biolink:NamedThing negative regulation of catecholamine metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. got7fsn_ti downregulation of catecholamine metabolic process|negative regulation of catecholamine metabolism|inhibition of catecholamine metabolic process|down regulation of catecholamine metabolic process|down-regulation of catecholamine metabolic process biological_process owl:Class
GO:0004117 biolink:NamedThing calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin. got7fsn_ti Reactome:R-HSA-111955 molecular_function owl:Class
GO:0004114 biolink:NamedThing 3',5'-cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. got7fsn_ti 3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity|cyclic 3',5'-nucleotide phosphodiesterase activity|3',5'-nucleotide phosphodiesterase activity|nucleoside-3',5-monophosphate phosphodiesterase activity|3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity|3',5'-cyclonucleotide phosphodiesterase activity|3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity|3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity|cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity|cyclic 3',5'-mononucleotide phosphodiesterase activity|cyclic 3',5-nucleotide monophosphate phosphodiesterase activity|nucleoside 3',5'-cyclic phosphate diesterase activity|PDE|3',5' cyclic-nucleotide phosphodiesterase activity|cyclic nucleotide phosphodiesterase activity|cyclic AMP phosphodiesterase activity|cyclic 3',5'-phosphodiesterase activity RHEA:14653|EC:3.1.4.17|Reactome:R-HSA-162425|MetaCyc:3.1.4.17-RXN molecular_function owl:Class
GO:0019820 biolink:NamedThing P2 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed. got7fsn_ti peroxisome vesicle Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. cellular_component owl:Class
GO:0030232 biolink:NamedThing insulin control element activator complex Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription. got7fsn_ti ICE activator complex cellular_component owl:Class
GO:0051359 biolink:NamedThing peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor. got7fsn_ti biosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine|biosynthesis of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. RESID:AA0379 biological_process owl:Class
GO:0002459 biolink:NamedThing adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae). got7fsn_ti adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains|adaptive immune response based on somatic recombination of VLR built from LRR domains|adaptive immune response in jawless fish biological_process owl:Class
GO:0002250 biolink:NamedThing adaptive immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). got7fsn_ti immune memory response|acquired immune response Wikipedia:Adaptive_immune_system biological_process owl:Class
GO:0047920 biolink:NamedThing geissoschizine dehydrogenase activity Catalysis of the reaction: geissoschizine + NADP(+) = 4,21-dehydrogeissoschizine + H(+) + NADPH. got7fsn_ti geissoschizine:NADP+ 4,21-oxidoreductase activity KEGG_REACTION:R03860|EC:1.3.1.36|RHEA:11376|MetaCyc:GEISSOSCHIZINE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0047085 biolink:NamedThing hydroxyphenylacetonitrile 2-monooxygenase activity Catalysis of the reaction: 4-hydroxyphenylacetonitrile + H(+) + NADPH + O(2) = 4-hydroxymandelonitrile + H(2)O + NADP(+). got7fsn_ti 4-hydroxyphenylacetonitrile hydroxylase activity|4-hydroxyphenylacetonitrile monooxygenase activity|4-hydroxyphenylacetonitrile,NADPH:oxygen oxidoreductase (2-hydroxylating) RHEA:23740|KEGG_REACTION:R02708|MetaCyc:1.14.13.42-RXN molecular_function owl:Class
GO:0015940 biolink:NamedThing pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. got7fsn_ti pantothenate synthesis|pantothenate biosynthetic process from 2-dehydropantolactone|pantothenate biosynthesis|pantothenate synthesis from valine|vitamin B5 biosynthetic process|pantothenate anabolism|pantothenate biosynthetic process from 2-oxypantoyl lactone|vitamin B5 biosynthesis|pantothenate biosynthesis from valine|pantothenate anabolism from 2-oxypantoyl lactone|pantothenate biosynthesis from 2-oxypantoyl lactone|pantothenate formation from valine|pantothenate anabolism from valine|pantothenate formation from 2-oxypantoyl lactone|pantothenate biosynthetic process from valine|pantothenate synthesis from 2-oxypantoyl lactone|pantothenate formation GO:0033318|GO:0033317 MetaCyc:PWY-4221|MetaCyc:PANTOSYN-PWY|MetaCyc:PANTO-PWY|MetaCyc:PWY-3961 biological_process owl:Class
GO:0030270 biolink:NamedThing formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran. got7fsn_ti FTR|formylmethanofuran-tetrahydromethanopterin formyltransferase activity|formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity|formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity|N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity|formylmethanofuran:tetrahydromethanopterin formyltransferase activity GO:0018714 RHEA:18061|EC:2.3.1.101|MetaCyc:2.3.1.101-RXN|UM-BBD_reactionID:r0346|KEGG_REACTION:R03390 molecular_function owl:Class
GO:0008232 biolink:NamedThing activator ecdysone receptor complex A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes. got7fsn_ti activator ecdysone receptor holocomplex cellular_component owl:Class
GO:0008230 biolink:NamedThing ecdysone receptor holocomplex A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes. got7fsn_ti cellular_component owl:Class
GO:1990019 biolink:NamedThing protein storage vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a protein storage vacuole, a storage vacuole that contains a lytic vacuole. got7fsn_ti tb 2012-12-20T21:00:09Z biological_process owl:Class
GO:0036202 biolink:NamedThing ent-cassa-12,15-diene 11-hydroxylase activity Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O. got7fsn_ti ent-cassadiene C11alpha-hydroxylase activity bf 2012-04-20T02:34:13Z KEGG_REACTION:R09866|EC:1.14.14.112|RHEA:31967 molecular_function owl:Class
GO:0060960 biolink:NamedThing cardiac neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron of the heart. got7fsn_ti heart neuron fate commitment dph 2009-09-30T10:23:47Z biological_process owl:Class
GO:0035898 biolink:NamedThing parathyroid hormone secretion The regulated release of parathyroid hormone into the circulatory system. got7fsn_ti PTH secretion|parathormone secretion|parathyrin secretion bf 2011-06-22T09:28:54Z biological_process owl:Class
GO:0060986 biolink:NamedThing endocrine hormone secretion The regulated release of a hormone into the circulatory system. got7fsn_ti dph 2010-01-11T09:03:48Z biological_process owl:Class
GO:0035313 biolink:NamedThing wound healing, spreading of epidermal cells The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis. got7fsn_ti biological_process owl:Class
GO:0044319 biolink:NamedThing wound healing, spreading of cells The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface. got7fsn_ti cell migration involved in wound healing epiboly jl 2010-07-14T02:10:01Z biological_process owl:Class
GO:0034470 biolink:NamedThing ncRNA processing Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules. got7fsn_ti biological_process owl:Class
GO:0032456 biolink:NamedThing endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. got7fsn_ti retrograde transport of endocytic vesicles|retrograde transport, endosome to plasma membrane https://github.com/geneontology/go-ontology/issues/20747 sp 2013-06-18T10:52:50Z GO:1990126 biological_process owl:Class
GO:0016197 biolink:NamedThing endosomal transport The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. got7fsn_ti endosome transport|endosome localization|endosome localisation GO:0032439 biological_process owl:Class
GO:0033130 biolink:NamedThing acetylcholine receptor binding Binding to an acetylcholine receptor. got7fsn_ti molecular_function owl:Class
GO:0045198 biolink:NamedThing establishment of epithelial cell apical/basal polarity The specification and formation of the apicobasal polarity of an epithelial cell. got7fsn_ti biological_process owl:Class
GO:0030859 biolink:NamedThing polarized epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis. got7fsn_ti biological_process owl:Class
GO:0043989 biolink:NamedThing histone H4-S1 phosphorylation The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone. got7fsn_ti histone H4S1 phosphorylation|histone H4 phosphorylation at S1 biological_process owl:Class
GO:0035404 biolink:NamedThing histone-serine phosphorylation The modification of histones by addition of a phosphate group to a serine residue. got7fsn_ti histone serine phosphorylation bf 2010-03-24T10:08:25Z biological_process owl:Class
GO:0070479 biolink:NamedThing nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction. got7fsn_ti 5'-3' NMD|5'-3' nonsense-mediated mRNA decay|5'-3' nonsense-mediated decay|nuclear-transcribed mRNA breakdown, 5'-3' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA degradation, 5'-3' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA catabolism, 5'-3' exonucleolytic nonsense-mediated decay biological_process owl:Class
GO:0070480 biolink:NamedThing exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-independent decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs independent of deadenylation, but requires decapping followed by transcript decay. got7fsn_ti exonucleolytic nuclear-transcribed mRNA degradation involved in deadenylation-independent decay|exonucleolytic nuclear-transcribed mRNA breakdown involved in deadenylation-independent decay|exonucleolytic nuclear-transcribed mRNA catabolism involved in deadenylation-independent decay biological_process owl:Class
GO:0031807 biolink:NamedThing H1 histamine receptor binding Binding to a H1 histamine receptor. got7fsn_ti H1 histamine receptor ligand molecular_function owl:Class
GO:0031806 biolink:NamedThing G protein-coupled histamine receptor binding Binding to a G protein-coupled (metabotropic) histamine receptor. got7fsn_ti G-protein coupled histamine receptor binding|metabotropic histamine receptor ligand|metabotropic histamine receptor binding molecular_function owl:Class
GO:0070571 biolink:NamedThing negative regulation of neuron projection regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. got7fsn_ti growth cone collapse mah 2009-04-15T01:43:19Z biological_process owl:Class
GO:0010977 biolink:NamedThing negative regulation of neuron projection development Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). got7fsn_ti negative regulation of neurite biosynthesis|negative regulation of neurite development|negative regulation of neurite growth|growth cone collapse|negative regulation of neurite formation tb 2009-06-01T10:47:42Z biological_process owl:Class
GO:0048531 biolink:NamedThing beta-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. got7fsn_ti molecular_function owl:Class
GO:0008378 biolink:NamedThing galactosyltransferase activity Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. got7fsn_ti Reactome:R-HSA-1964501 molecular_function owl:Class
GO:0080146 biolink:NamedThing L-cysteine desulfhydrase activity Catalysis of the reaction: L-cysteine + H2O = ammonia + pyruvate + hydrogen sulfide + H+. got7fsn_ti dhl 2010-01-27T04:50:43Z Reactome:R-HSA-1614591|MetaCyc:LCYSDESULF-RXN|Reactome:R-HSA-1614614|RHEA:24931|EC:4.4.1.1 molecular_function owl:Class
GO:0038133 biolink:NamedThing ERBB2-ERBB3 signaling pathway A series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission. got7fsn_ti ERBB2-ERBB3 signalling pathway|HER2-HER3 signaling pathway bf 2012-03-30T11:10:44Z biological_process owl:Class
GO:0038129 biolink:NamedThing ERBB3 signaling pathway A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission. got7fsn_ti HER3 signaling pathway|receptor tyrosine-protein kinase erbB-3 signaling pathway|ERBB3 signalling pathway bf 2012-03-30T10:42:28Z biological_process owl:Class
GO:0070081 biolink:NamedThing clathrin-sculpted monoamine transport vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing monoamines. got7fsn_ti clathrin sculpted monoamine transport vesicle|clathrin sculpted monoamine constitutive secretory pathway transport vesicle cellular_component owl:Class
GO:0060198 biolink:NamedThing clathrin-sculpted vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release. got7fsn_ti clathrin sculpted vesicle cellular_component owl:Class
GO:0090727 biolink:NamedThing positive regulation of brood size Any process that increases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. got7fsn_ti tb 2016-12-19T15:07:32Z biological_process owl:Class
GO:0060378 biolink:NamedThing regulation of brood size Any process that modulates brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. got7fsn_ti biological_process owl:Class
GO:0000754 biolink:NamedThing adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae. got7fsn_ti adaptation to pheromone during conjugation with cellular fusion|desensitization to pheromone during conjugation with cellular fusion|adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion GO:0030453|GO:0007331 biological_process owl:Class
GO:0102650 biolink:NamedThing cyclo-acetoacetyl-L-tryptophan synthetase activity Catalysis of the reaction: acetoacetyl-ACP + L-tryptophan + ATP <=> cyclo-acetoacetyl-L-tryptophan + AMP + diphosphoric acid + 2 H+ + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-15811 molecular_function owl:Class
GO:0032288 biolink:NamedThing myelin assembly The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system. got7fsn_ti myelin formation biological_process owl:Class
GO:0010927 biolink:NamedThing cellular component assembly involved in morphogenesis The cellular component assembly that is part of the initial shaping of the component during its developmental progression. got7fsn_ti biological_process owl:Class
GO:0009846 biolink:NamedThing pollen germination The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture. got7fsn_ti biological_process owl:Class
GO:0070211 biolink:NamedThing Snt2C complex A histone deacetylase complex that is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains Snt2p, Ecm5p and Rpd3p. got7fsn_ti cellular_component owl:Class
GO:0016360 biolink:NamedThing sensory organ precursor cell fate determination The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti sense organ precursor cell fate determination biological_process owl:Class
GO:0035176 biolink:NamedThing social behavior Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group. got7fsn_ti social behaviour|cooperative behavior Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior. Wikipedia:Social_behavior biological_process owl:Class
GO:0098933 biolink:NamedThing disruption by symbiont of host cell envelope The process by which a symbiont breaks down the cell wall of its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0052008 biolink:NamedThing disruption by symbiont of host cellular component The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti catabolism of host structural constituent by organism|catabolism of host cellular component by organism|disassembly by symbiont of host cellular component|degradation of host cellular component by organism|disassembly by organism of host cellular component biological_process owl:Class
GO:0106258 biolink:NamedThing L-serine-phosphatidylcholine phosphatidyltransferase activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phosphocholine + L-serine = 1,2-diacyl-sn-glycero-3-phospho-L-serine + choline. got7fsn_ti hjd 2020-04-21T17:31:56Z RHEA:45088 molecular_function owl:Class
GO:0005943 biolink:NamedThing phosphatidylinositol 3-kinase complex, class IA A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. got7fsn_ti class IA PI3K complex|phosphoinositide 3-kinase complex, class IA|1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex|1-phosphatidylinositol-4-phosphate kinase, class IA complex GO:0035030 cellular_component owl:Class
GO:0097651 biolink:NamedThing phosphatidylinositol 3-kinase complex, class I A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast. got7fsn_ti class I phosphatidylinositol 3-kinase complex|class I PI3K complex pr 2014-09-16T11:19:58Z cellular_component owl:Class
GO:0061411 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to cold Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. got7fsn_ti dph 2012-01-12T12:31:33Z biological_process owl:Class
GO:0061244 biolink:NamedThing mesonephric S-shaped body morphogenesis The process in which the mesonephric S-shaped body is generated and organized. The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros. got7fsn_ti dph 2010-08-19T03:23:55Z biological_process owl:Class
GO:0072050 biolink:NamedThing S-shaped body morphogenesis The process in which the S-shaped body is generated and organized. The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron. got7fsn_ti mah 2010-01-25T03:45:19Z biological_process owl:Class
GO:1900606 biolink:NamedThing tensidol B metabolic process The chemical reactions and pathways involving tensidol B. got7fsn_ti tensidol B metabolism di 2012-05-15T06:58:21Z biological_process owl:Class
GO:0007307 biolink:NamedThing eggshell chorion gene amplification Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster. got7fsn_ti biological_process owl:Class
GO:0006486 biolink:NamedThing protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. got7fsn_ti protein amino acid glycosylation|protein-carbohydrate complex assembly GO:0065006 biological_process owl:Class
GO:0043413 biolink:NamedThing macromolecule glycosylation The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. got7fsn_ti biological_process owl:Class
GO:0044538 biolink:NamedThing host cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell. got7fsn_ti jl 2012-03-21T03:26:33Z cellular_component owl:Class
GO:0097267 biolink:NamedThing omega-hydroxylase P450 pathway The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation. got7fsn_ti P450 omega-hydroxylase pathway pr 2012-03-15T12:58:15Z biological_process owl:Class
GO:0075226 biolink:NamedThing encysted zoospore germination The physiological, developmental and morphological changes that occur in an encysted zoospore, that germinates by developing a germ tube that may penetrate the host directly or indirectly through an appressorium. An encysted zoospore is a zoospore which has shed its flagellum and whose membrane has fused to form a walled cyst. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti encysted zoospore germination on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0009847 biolink:NamedThing spore germination The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall). got7fsn_ti spore germination on or near host GO:0075005 biological_process owl:Class
GO:0102852 biolink:NamedThing 1-18:3-2-16:0-phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:3-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8319 molecular_function owl:Class
GO:0005894 biolink:NamedThing interleukin-3 receptor complex A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5. got7fsn_ti IL-3 receptor complex cellular_component owl:Class
GO:0016979 biolink:NamedThing lipoate-protein ligase activity Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP. got7fsn_ti lipoate-protein ligase activity (lipoylation of glycine cleavage complex)|lipoate-protein ligase A activity|lipoate-protein ligase B activity GO:0016978|GO:0008916|GO:0102315 EC:6.3.1.20|RHEA:49288|MetaCyc:RXN-13039|MetaCyc:RXN0-1141|MetaCyc:RXN-8655|MetaCyc:RXN-8654 molecular_function owl:Class
GO:0004608 biolink:NamedThing phosphatidylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine. got7fsn_ti S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity|phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity|LMTase activity|lipid methyl transferase activity|phosphatidylethanolamine methyltransferase activity|PEMT|phosphatidylethanolamine-N-methylase activity MetaCyc:2.1.1.17-RXN|EC:2.1.1.17|RHEA:11164|Reactome:R-HSA-1483174|KEGG_REACTION:R02056 molecular_function owl:Class
GO:0018578 biolink:NamedThing protocatechuate 3,4-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate. got7fsn_ti protocatechuic acid oxidase activity|protocatechuic 3,4-oxygenase activity|protocatechuic 3,4-dioxygenase activity|protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)|protocatechuate oxygenase activity MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN|EC:1.13.11.3|RHEA:10084|UM-BBD_reactionID:r0143 molecular_function owl:Class
GO:0051012 biolink:NamedThing microtubule sliding The movement of one microtubule along another microtubule. got7fsn_ti microtubule translocation biological_process owl:Class
GO:0031129 biolink:NamedThing inductive cell-cell signaling Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate. got7fsn_ti inductive cell-cell signalling biological_process owl:Class
GO:0047875 biolink:NamedThing ecdysone oxidase activity Catalysis of the reaction: Ecdysone + O(2) = 3-dehydroecdysone + H(2)O(2). got7fsn_ti beta-ecdysone oxidase activity|ecdysone:oxygen 3-oxidoreductase activity KEGG_REACTION:R02373|RHEA:11796|EC:1.1.3.16|MetaCyc:ECDYSONE-OXIDASE-RXN molecular_function owl:Class
GO:0044578 biolink:NamedThing butyryl-CoA biosynthetic process The chemical reactions and pathway resulting in the formation of butyryl-CoA. got7fsn_ti butyryl-CoA biosynthesis jl 2012-04-19T04:23:26Z biological_process owl:Class
GO:0006633 biolink:NamedThing fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. got7fsn_ti fatty acid synthesis|fatty acid anabolism|fatty acid biosynthesis|fatty acid formation GO:0000037 Wikipedia:Fatty_acid_synthesis|MetaCyc:FASYN-INITIAL-PWY|MetaCyc:PWY-5156|MetaCyc:PWY-4381 biological_process owl:Class
GO:0004954 biolink:NamedThing prostanoid receptor activity Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0004953 biolink:NamedThing icosanoid receptor activity Combining with an icosanoid to initiate a change in cell activity. got7fsn_ti eicosanoid receptor activity molecular_function owl:Class
GO:0035144 biolink:NamedThing anal fin morphogenesis The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. got7fsn_ti biological_process owl:Class
GO:0035141 biolink:NamedThing medial fin morphogenesis The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. got7fsn_ti median fin morphogenesis|unpaired fin morphogenesis biological_process owl:Class
GO:0106048 biolink:NamedThing spermidine deacetylation The modification of acetylspermadine by the removal of acetyl groups. got7fsn_ti N8-acetylspermidine deacetylation hjd 2017-08-01T18:39:17Z biological_process owl:Class
GO:0106047 biolink:NamedThing polyamine deacetylation The modification of acetylpolyamine by the removal of acetyl groups. got7fsn_ti hjd 2017-08-01T18:36:46Z biological_process owl:Class
GO:0102604 biolink:NamedThing naringenin,NADPH:oxygen oxidoreductase activity Catalysis of the reaction: (S)-naringenin(1-) + O2 + NADPH + H+ <=> 2-hydroxy-2,3-dihydrogenistein-7-olate + NADP + H2O. got7fsn_ti RHEA:35487|EC:1.14.14.87|MetaCyc:RXN-1541 molecular_function owl:Class
GO:0048830 biolink:NamedThing adventitious root development The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot. got7fsn_ti biological_process owl:Class
GO:0030370 biolink:NamedThing intercellular adhesion molecule-3 receptor binding Binding to a receptor for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1. got7fsn_ti intercellular adhesion molecule-3 receptor ligand|ICAM-3 receptor ligand|ICAM-3 receptor binding molecular_function owl:Class
GO:0030778 biolink:NamedThing columbamine O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine. got7fsn_ti S-adenosyl-L-methionine:columbamine O-methyltransferase activity KEGG_REACTION:R03721|RHEA:15373|MetaCyc:2.1.1.118-RXN|EC:2.1.1.118 molecular_function owl:Class
GO:0005736 biolink:NamedThing RNA polymerase I complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. got7fsn_ti DNA-directed RNA polymerase I complex|DNA-directed RNA polymerase I activity cellular_component owl:Class
GO:0034975 biolink:NamedThing protein folding in endoplasmic reticulum A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation). got7fsn_ti protein folding in ER|oxidative protein folding biological_process owl:Class
GO:0006457 biolink:NamedThing protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. got7fsn_ti co-chaperonin activity|chaperonin ATPase activity|glycoprotein-specific chaperone activity|non-chaperonin molecular chaperone ATPase activity|chaperone activity|protein complex assembly, multichaperone pathway|chaperonin-mediated tubulin folding|alpha-tubulin folding|beta-tubulin folding|co-chaperone activity GO:0007024|GO:0007022|GO:0007025 Wikipedia:Protein_folding biological_process owl:Class
GO:0009250 biolink:NamedThing glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. got7fsn_ti glucan synthesis|glucan formation|glucan anabolism|glucan biosynthesis biological_process owl:Class
GO:0014002 biolink:NamedThing astrocyte development The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. got7fsn_ti astrocyte cell development biological_process owl:Class
GO:0034245 biolink:NamedThing mitochondrial DNA-directed RNA polymerase complex A DNA-directed RNA polymerase complex located in the mitochondrion. Mitochondrial RNA polymerase is composed of two subunits, a catalytic core, which resembles the enzymes from bacteriophage T7 and T3, and a specificity factor required for promoter recognition, which is similar to members of the eubacterial sigma factor family. In S. cerevisiae, these are encoded by the nuclear genes RPO41 and MTF1 and the specificity factor, required for promoter recognition and initiation, is not present in the elongating form. got7fsn_ti mitochondrial RNA polymerase complex|mitochondrial RNA polymerase holoenzyme complex cellular_component owl:Class
GO:0110072 biolink:NamedThing apical constriction involved in ventral furrow formation The actin-mediated process that results in contraction of the apical end of a polarized columnar epithelial cell, contributing to formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation. got7fsn_ti kmv 2017-12-06T17:04:49Z biological_process owl:Class
GO:0003384 biolink:NamedThing apical constriction involved in gastrulation The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation. got7fsn_ti dph 2009-12-09T07:35:38Z biological_process owl:Class
GO:0070939 biolink:NamedThing Dsl1/NZR complex A multisubunit tethering complex, i.e. a protein complex involved in mediating the initial interaction between vesicles and the membranes with which they fuse, that is involved in trafficking from the Golgi apparatus to the ER. In Saccharomyces cerevisiae the Dsl1p complex contains Dsl1p, Tip20p, and Sec39p. got7fsn_ti Dsl1p complex|CATCHR family complex|NZR complex See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. mah 2009-09-22T03:41:38Z cellular_component owl:Class
GO:0052873 biolink:NamedThing FMN reductase (NADPH) activity Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+. got7fsn_ti NADPH(2) dehydrogenase (FMN) activity|NADPH:FMN oxidoreductase activity|NADPH dehydrogenase (FMN) activity|NADPH2 dehydrogenase (FMN)|NADPH-FMN reductase activity|NADPH(2):FMN oxidoreductase activity|NADPH-dependent FMN reductase activity|SsuE|FMNH2:NADP+ oxidoreductase activity|flavin mononucleotide reductase activity|flavine mononucleotide reductase activity|NADPH2:FMN oxidoreductase activity|NADPH:flavin oxidoreductase activity EC:1.5.1.38|EC:1.5.1.39|Reactome:R-HSA-1222399|KEGG_REACTION:R05706|RHEA:21624 molecular_function owl:Class
GO:0070186 biolink:NamedThing growth hormone activity The action characteristic of growth hormone, a peptide hormone that is secreted by the anterior pituitary or the placenta into the circulation, and binds to membrane receptors in target tissues to stimulate body growth. got7fsn_ti pituitary growth hormone activity|GH activity|placental growth hormone activity molecular_function owl:Class
GO:0033134 biolink:NamedThing ubiquitin activating enzyme binding Binding to a ubiquitin activating enzyme, any of the E1 proteins. got7fsn_ti molecular_function owl:Class
GO:0010721 biolink:NamedThing negative regulation of cell development Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0098953 biolink:NamedThing receptor diffusion trapping The process by which a membrane receptor, diffusing freely within the plasma membeane, becomes trapped in some plasma membrane region. This can happen when a receptor bind, directly or indirectly, to some component of the underlying matrix. got7fsn_ti biological_process owl:Class
GO:0042377 biolink:NamedThing vitamin K catabolic process The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. got7fsn_ti naphthoquinone catabolic process|naphthoquinone catabolism|vitamin K degradation|vitamin K catabolism|vitamin K breakdown biological_process owl:Class
GO:0061026 biolink:NamedThing cardiac muscle tissue regeneration The regrowth of cardiac muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. got7fsn_ti dph 2010-02-09T08:25:51Z biological_process owl:Class
GO:0042246 biolink:NamedThing tissue regeneration The regrowth of lost or destroyed tissues. got7fsn_ti biological_process owl:Class
GO:0010996 biolink:NamedThing response to auditory stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus. got7fsn_ti response to sound|response to sound stimulus tb 2009-06-10T11:09:38Z biological_process owl:Class
GO:0009612 biolink:NamedThing response to mechanical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. got7fsn_ti mechanical stimulus response|chemi-mechanical coupling biological_process owl:Class
GO:0070867 biolink:NamedThing mating projection tip membrane The portion of the plasma membrane surrounding a mating projection tip. got7fsn_ti mating projection membrane fusion domain|shmoo tip membrane mah 2009-08-19T04:05:58Z cellular_component owl:Class
GO:1990595 biolink:NamedThing mast cell secretagogue receptor activity Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells. got7fsn_ti sp 2014-12-22T10:04:43Z molecular_function owl:Class
GO:0048720 biolink:NamedThing posterior cibarial plate morphogenesis The process in which the anatomical structures of the posterior cibarial plate are generated and organized. got7fsn_ti biological_process owl:Class
GO:0050268 biolink:NamedThing coniferyl-alcohol dehydrogenase activity Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH. got7fsn_ti coniferyl-alcohol:NADP+ oxidoreductase activity MetaCyc:RXN-2602|RHEA:22444|EC:1.1.1.194 molecular_function owl:Class
GO:0003148 biolink:NamedThing outflow tract septum morphogenesis The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. got7fsn_ti tb 2009-09-22T07:51:01Z biological_process owl:Class
GO:0060411 biolink:NamedThing cardiac septum morphogenesis The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart. got7fsn_ti heart septum morphogenesis GO:0003280 biological_process owl:Class
GO:0050218 biolink:NamedThing propionate-CoA ligase activity Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA. got7fsn_ti propanoate:CoA ligase (AMP-forming)|propionyl-CoA synthetase activity RHEA:20373|MetaCyc:PROPIONATE--COA-LIGASE-RXN|EC:6.2.1.17 molecular_function owl:Class
GO:0031689 biolink:NamedThing A3 adenosine receptor binding Binding to an A3 adenosine receptor. got7fsn_ti A3 adenosine receptor ligand molecular_function owl:Class
GO:0031685 biolink:NamedThing adenosine receptor binding Binding to an adenosine receptor. got7fsn_ti adenosine receptor ligand molecular_function owl:Class
GO:0051305 biolink:NamedThing chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes. got7fsn_ti chromosome movement to spindle pole|chromosome migration to spindle pole|chromosome movement biological_process owl:Class
GO:0009538 biolink:NamedThing photosystem I reaction center A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. got7fsn_ti photosystem I reaction centre cellular_component owl:Class
GO:0047864 biolink:NamedThing dimethylaniline-N-oxide aldolase activity Catalysis of the reaction: N,N-dimethylaniline N-oxide = N-methylaniline + formaldehyde. got7fsn_ti microsomal oxidase II|N,N-dimethylaniline-N-oxide formaldehyde-lyase (N-methylaniline-forming)|N,N-dimethylaniline-N-oxide formaldehyde-lyase activity|microsomal N-oxide dealkylase activity RHEA:19321|MetaCyc:DIMETHYLANILINE-N-OXIDE-ALDOLASE-RXN|EC:4.1.2.24|KEGG_REACTION:R03345 molecular_function owl:Class
GO:0000447 biolink:NamedThing endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. got7fsn_ti endonucleolytic cleavage at A2 biological_process owl:Class
GO:0000479 biolink:NamedThing endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae. got7fsn_ti biological_process owl:Class
GO:0018623 biolink:NamedThing benzoate 1,2-dioxygenase activity Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+. got7fsn_ti benzoate dioxygenase activity|benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)|benzoic hydroxylase activity|benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)|benzoate hydroxylase activity RHEA:12633|UM-BBD_enzymeID:e0154|EC:1.14.12.10|MetaCyc:BENZOATE-12-DIOXYGENASE-RXN molecular_function owl:Class
GO:0102203 biolink:NamedThing brassicasterol glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol <=> UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+. got7fsn_ti RHEA:61840|MetaCyc:RXN-12125|EC:2.4.1.173 molecular_function owl:Class
GO:0102717 biolink:NamedThing DIBOA-glucoside oxygenase activity Catalysis of the reaction: DIBOA-beta-D-glucoside + O2 + 2-oxoglutarate <=> TRIBOA-beta-D-glucoside + succinate + carbon dioxide. got7fsn_ti RHEA:32115|EC:1.14.11.59|MetaCyc:RXN-6685 molecular_function owl:Class
GO:0070327 biolink:NamedThing thyroid hormone transport The directed movement of thyroid hormone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti triiodothyronine transport|thyroxine transport biological_process owl:Class
GO:0009914 biolink:NamedThing hormone transport The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0140231 biolink:NamedThing anterograde axonal transport of neurotransmitter receptor complex The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons. got7fsn_ti pg 2018-07-09T09:41:37Z biological_process owl:Class
GO:0099641 biolink:NamedThing anterograde axonal protein transport The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons. got7fsn_ti anterograde axon cargo transport biological_process owl:Class
GO:0051615 biolink:NamedThing histamine uptake The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. got7fsn_ti histamine import biological_process owl:Class
GO:0001504 biolink:NamedThing neurotransmitter uptake The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. got7fsn_ti neurotransmitter import|neurotransmitter recycling|neurotransmitter import into neuron|neurotransmitter import into glial cell biological_process owl:Class
GO:0050097 biolink:NamedThing methylaspartate mutase activity Catalysis of the reaction: threo-3-methyl-L-aspartate = L-glutamate. got7fsn_ti glutamate mutase activity|glutamic isomerase activity|beta-methylaspartate-glutamate mutase activity|glutamic acid mutase activity|b-methylaspartate-glutamate mutase activity|glutamic mutase activity|L-threo-3-methylaspartate carboxy-aminomethylmutase activity|methylaspartic acid mutase activity|glutamate isomerase activity|glutamic acid isomerase activity EC:5.4.99.1|RHEA:12857|KEGG_REACTION:R00262|MetaCyc:METHYLASPARTATE-MUTASE-RXN molecular_function owl:Class
GO:0008872 biolink:NamedThing glucarate dehydratase activity Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O. got7fsn_ti D-glucarate hydro-lyase activity|D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)|D-glucarate dehydratase activity MetaCyc:GLUCARDEHYDRA-RXN|EC:4.2.1.40|RHEA:14573 molecular_function owl:Class
GO:0046010 biolink:NamedThing positive regulation of circadian sleep/wake cycle, non-REM sleep Any process that activates or increases the duration or quality of non-rapid eye movement (NREM) sleep. got7fsn_ti stimulation of circadian sleep/wake cycle, non-REM sleep|up regulation of circadian sleep/wake cycle, non-REM sleep|positive regulation of non-REM sleep|activation of circadian sleep/wake cycle, non-REM sleep|upregulation of circadian sleep/wake cycle, non-REM sleep|up-regulation of circadian sleep/wake cycle, non-REM sleep biological_process owl:Class
GO:0050448 biolink:NamedThing beta-cyclopiazonate dehydrogenase activity Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2). got7fsn_ti beta-cyclopiazonate:acceptor oxidoreductase (cyclizing)|beta-cyclopiazonate oxidocyclase activity|beta-cyclopiazonate:(acceptor) oxidoreductase (cyclizing)|b-cyclopiazonate dehydrogenase activity|beta-cyclopiazonic oxidocyclase activity KEGG_REACTION:R04080|RHEA:14525|EC:1.21.99.1|MetaCyc:BETA-CYCLOPIAZONATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0007300 biolink:NamedThing ovarian nurse cell to oocyte transport Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster. got7fsn_ti nurse cell to oocyte transport biological_process owl:Class
GO:0106367 biolink:NamedThing dGTP dependent (deoxy)nucleoside -phosphate kinase activity Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP. got7fsn_ti hjd 2021-03-11T20:06:53Z RHEA:62128 molecular_function owl:Class
GO:0097391 biolink:NamedThing chemokine (C-X-C motif) ligand 13 production The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CXCL13 production pr 2012-10-23T07:58:28Z biological_process owl:Class
GO:0002034 biolink:NamedThing maintenance of blood vessel diameter homeostasis by renin-angiotensin The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system. got7fsn_ti renin-angiotensin regulation of blood vessel size|regulation of blood vessel diameter by renin-angiotensin|regulation of blood vessel size by renin-angiotensin https://github.com/geneontology/go-ontology/issues/12253 biological_process owl:Class
GO:0003081 biolink:NamedThing regulation of systemic arterial blood pressure by renin-angiotensin The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system. got7fsn_ti blood pressure regulation by renin-angiotensin biological_process owl:Class
GO:0007612 biolink:NamedThing learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience. got7fsn_ti Wikipedia:Learning biological_process owl:Class
GO:0007611 biolink:NamedThing learning or memory The acquisition and processing of information and/or the storage and retrieval of this information over time. got7fsn_ti biological_process owl:Class
GO:0103000 biolink:NamedThing UDP-glucose:4-hydroxylamino-2,6-dinitrotoluene-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 4-hydroxylamino-2,6-dinitrotoluene <=> 4-hydroxylamino-2,6-dinitrotoluene-O-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-9748 molecular_function owl:Class
GO:0097277 biolink:NamedThing cellular urea homeostasis Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell. got7fsn_ti pr 2012-03-22T02:57:08Z biological_process owl:Class
GO:0097274 biolink:NamedThing urea homeostasis Any biological process involved in the maintenance of an internal steady state of urea. got7fsn_ti pr 2012-03-22T02:53:39Z biological_process owl:Class
GO:0033658 biolink:NamedThing modification by symbiont of host chloroplast thylakoid The process in which an organism effects a change in the structure or function of the host cell chloroplast thylakoid. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0033657 biolink:NamedThing modification by symbiont of host chloroplast part The process in which an organism effects a change in the structure or function of a component of the host cell chloroplast. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0047119 biolink:NamedThing 2-methyl-branched-chain-enoyl-CoA reductase activity Catalysis of the reaction: 2-methylbutanoyl-CoA + NAD(+) = 2-methylbut-2-enoyl-CoA + H(+) + NADH. got7fsn_ti 2-methyl-branched-chain-acyl-CoA:NAD+ 2-oxidoreductase activity EC:1.3.1.52|RHEA:24532|MetaCyc:1.3.1.52-RXN|KEGG_REACTION:R03169 molecular_function owl:Class
GO:0098860 biolink:NamedThing actin filament bundle of stereocilium A bundle of hundreds of cross-linked actin filaments (an actin cable), that is the supporting structure of a stereocilium. Filaments are oriented such that the the plus (barbed) ends are at the tip of the protrusion and are capped by a tip complex which bridges to the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0097518 biolink:NamedThing parallel actin filament bundle An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity. got7fsn_ti pr 2013-10-16T15:42:17Z cellular_component owl:Class
GO:0047650 biolink:NamedThing alkylglycerone kinase activity Catalysis of the reaction: O-alkylglycerone + ATP = O-alkylglycerone phosphate + ADP + 2 H(+). got7fsn_ti alkyldihydroxyacetone kinase (phosphorylating)|alkyldihydroxyacetone kinase activity|ATP:O-alkylglycerone phosphotransferase activity EC:2.7.1.84|MetaCyc:ALKYLGLYCERONE-KINASE-RXN|KEGG_REACTION:R03944|RHEA:23088 molecular_function owl:Class
GO:0048096 biolink:NamedThing chromatin-mediated maintenance of transcription Maintenance of transcription by remodelling of chromatin into an 'open configuration'. Once established, this regulation is mitotically stable and is maintained over many cell divisions. It is also heritable. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21730 Note that this process is the opposite of chromatin silencing. This regulation is exemplified by members of the trithorax group, which maintain the active state of homeotic gene transcription. Do not confuse with GO:0140673 ; label "chromatin maintenance during transcription elongation, which describes the reforming of chromatin after RNA polymerase II passage. biological_process owl:Class
GO:0045893 biolink:NamedThing positive regulation of transcription, DNA-templated Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. got7fsn_ti stimulation of transcription, DNA-dependent|transcription activator activity|positive regulation of gene-specific transcription|up regulation of transcription, DNA-dependent|upregulation of transcription, DNA-dependent|activation of transcription, DNA-dependent|stimulation of gene-specific transcription|activation of gene-specific transcription|positive regulation of cellular transcription, DNA-dependent|up regulation of gene-specific transcription|positive regulation of transcription, DNA-dependent|up-regulation of gene-specific transcription|up-regulation of transcription, DNA-dependent|upregulation of gene-specific transcription GO:0045941|GO:0061020|GO:0043193 biological_process owl:Class
GO:0035325 biolink:NamedThing Toll-like receptor binding Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. got7fsn_ti TLR binding bf 2010-02-26T10:11:55Z molecular_function owl:Class
GO:0016182 biolink:NamedThing synaptic vesicle budding from endosome Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes. got7fsn_ti synaptic vesicle budding involved in synaptic vesicle exocytosis|endosome to synaptic vesicle budding biological_process owl:Class
GO:0047806 biolink:NamedThing cytochrome-c3 hydrogenase activity Catalysis of the reaction: 2 H2 + ferricytochrome c3 = 4 H+ + ferrocytochrome c3. got7fsn_ti cytochrome hydrogenase activity|hydrogen:ferricytochrome-c3 oxidoreductase activity|H2:ferricytochrome c3 oxidoreductase activity|H(2):ferricytochrome c3 oxidoreductase activity|cytochrome c3 reductase activity EC:1.12.2.1|UM-BBD_enzymeID:e0481|RHEA:20625|MetaCyc:CYTOCHROME-C3-HYDROGENASE-RXN molecular_function owl:Class
GO:0016697 biolink:NamedThing oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome. got7fsn_ti GO:0016698 EC:1.12.2.- molecular_function owl:Class
GO:0048574 biolink:NamedThing long-day photoperiodism, flowering A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light that exceeds the critical day length. The critical day length varies between species. Although the term is long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 minus the critical day length. got7fsn_ti response to long-day, flowering|short-night photoperiodism, flowering|long-day photoperiodic control of inflorescence development|long-day photoperiodic control of flowering|long-day photoperiodic control of flowering time|response to short-night, flowering biological_process owl:Class
GO:0048571 biolink:NamedThing long-day photoperiodism Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that exceeds a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term long-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness falls short of the number of hours defined by 24 hours minus the critical day length. got7fsn_ti response to long-day photoperiod|short-night photoperiodism|response to short-night|response to long-day biological_process owl:Class
GO:0010341 biolink:NamedThing gibberellin carboxyl-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester. got7fsn_ti molecular_function owl:Class
GO:0010340 biolink:NamedThing carboxyl-O-methyltransferase activity Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. got7fsn_ti molecular_function owl:Class
GO:0034289 biolink:NamedThing detection of maltose stimulus The series of events in which a maltose stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of maltose stimulus biological_process owl:Class
GO:0034286 biolink:NamedThing response to maltose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a maltose stimulus. got7fsn_ti response to maltose stimulus biological_process owl:Class
GO:0055019 biolink:NamedThing negative regulation of cardiac muscle fiber development Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development. got7fsn_ti downregulation of cardiac muscle fiber development|down-regulation of cardiac muscle fiber development|down regulation of cardiac muscle fiber development|negative regulation of cardiac muscle fibre development|negative regulation of heart muscle fiber development|inhibition of cardiac muscle fiber development biological_process owl:Class
GO:0019705 biolink:NamedThing protein-cysteine S-myristoyltransferase activity Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]. got7fsn_ti RHEA:59736 molecular_function owl:Class
GO:0019107 biolink:NamedThing myristoyltransferase activity Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. got7fsn_ti Reactome:R-HSA-162914|Reactome:R-HSA-141367 molecular_function owl:Class
GO:0000347 biolink:NamedThing THO complex The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. got7fsn_ti cellular_component owl:Class
GO:0001675 biolink:NamedThing acrosome assembly The formation of the acrosome from the spermatid Golgi. got7fsn_ti acrosome formation biological_process owl:Class
GO:0072106 biolink:NamedThing regulation of ureteric bud formation Any process that modulates the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. got7fsn_ti mah 2010-02-12T02:34:40Z biological_process owl:Class
GO:0090183 biolink:NamedThing regulation of kidney development Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti regulation of nephrogenesis tb 2009-12-18T10:50:56Z biological_process owl:Class
GO:0033431 biolink:NamedThing CGA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CGA codon. got7fsn_ti arginine tRNA Note that in the standard genetic code, CGA codes for arginine. molecular_function owl:Class
GO:0031735 biolink:NamedThing CCR10 chemokine receptor binding Binding to a CCR10 chemokine receptor. got7fsn_ti CCR10 chemokine receptor ligand molecular_function owl:Class
GO:1990027 biolink:NamedThing S bouton Synaptic bouton found in the ventral horn of the spinal cord. S boutons range in diameter from 0.5 to 8 um and contain spherical synaptic vesicles. got7fsn_ti pr 2013-02-06T10:35:12Z NIF_Subcellular:nlx_subcell_100207 cellular_component owl:Class
GO:0018263 biolink:NamedThing isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine. got7fsn_ti RESID:AA0216 biological_process owl:Class
GO:0140081 biolink:NamedThing glycosylated region protein binding Binding to a glycosylated region of a protein. got7fsn_ti pg 2017-07-25T10:58:31Z molecular_function owl:Class
GO:0035626 biolink:NamedThing juvenile hormone mediated signaling pathway A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity. got7fsn_ti juvenile hormone-mediated signaling pathway|juvenile hormone mediated signalling pathway bf 2010-12-08T04:45:25Z biological_process owl:Class
GO:0032989 biolink:NamedThing cellular component morphogenesis The process in which cellular structures, including whole cells or cell parts, are generated and organized. got7fsn_ti cellular structure morphogenesis biological_process owl:Class
GO:0071355 biolink:NamedThing cellular response to interleukin-9 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus. got7fsn_ti cellular response to IL-9 mah 2009-12-11T02:51:26Z biological_process owl:Class
GO:0047915 biolink:NamedThing ganglioside galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine = UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine. got7fsn_ti GM1-synthase activity|uridine diphosphogalactose-ceramide galactosyltransferase activity|UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase activity|UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity|uridine diphosphogalactose-GM2 galactosyltransferase activity|UDPgalactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase activity|UDP-galactose-GM2 galactosyltransferase activity|UDP-galactose-GM2 ganglioside galactosyltransferase activity|uridine diphosphate D-galactose:glycolipid galactosyltransferase activity|UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase activity|UDPgalactose-ceramide galactosyltransferase activity EC:2.4.1.62|MetaCyc:GANGLIOSIDE-GALACTOSYLTRANSFERASE-RXN|RHEA:16773 molecular_function owl:Class
GO:0003318 biolink:NamedThing cell migration to the midline involved in heart development The orderly movement of a cell toward the midline that contributes to the progression of the heart over time. got7fsn_ti dph 2009-10-27T09:15:43Z biological_process owl:Class
GO:0050571 biolink:NamedThing 1,5-anhydro-D-fructose reductase activity Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH. got7fsn_ti 1,5-anhydro-D-glucitol:NADP+ oxidoreductase activity|AF reductase activity MetaCyc:1.1.1.263-RXN|KEGG_REACTION:R05682|RHEA:20665|EC:1.1.1.263 molecular_function owl:Class
GO:0009756 biolink:NamedThing carbohydrate mediated signaling A series of molecular signals mediated by the detection of carbohydrate. got7fsn_ti carbohydrate mediated signalling biological_process owl:Class
GO:0043987 biolink:NamedThing histone H3-S10 phosphorylation The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone. got7fsn_ti histone H3S10 phosphorylation|histone H3 phosphorylation at S10 GO:0043986 biological_process owl:Class
GO:0008236 biolink:NamedThing serine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). got7fsn_ti serine protease activity Reactome:R-HSA-3132753|Reactome:R-HSA-6801766|Reactome:R-HSA-1461993|Reactome:R-HSA-2022383 molecular_function owl:Class
GO:0017171 biolink:NamedThing serine hydrolase activity Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). got7fsn_ti molecular_function owl:Class
GO:0072150 biolink:NamedThing juxtaglomerulus cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a juxtaglomerulus cell. got7fsn_ti mah 2010-02-24T02:09:49Z biological_process owl:Class
GO:0043233 biolink:NamedThing organelle lumen The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen. got7fsn_ti cellular_component owl:Class
GO:0047879 biolink:NamedThing erythronolide synthase activity Catalysis of the reaction: 6 malonyl-CoA + propionyl-CoA = 7 CoA + 6-deoxyerythronolide B. got7fsn_ti malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing)|erythronolide condensing enzyme activity MetaCyc:ERYTHRONOLIDE-SYNTHASE-RXN|RHEA:23068|EC:2.3.1.94 molecular_function owl:Class
GO:0008932 biolink:NamedThing lytic endotransglycosylase activity Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends. got7fsn_ti murein lytic endotransglycosylase E activity EC:2.4.99.- molecular_function owl:Class
GO:0008933 biolink:NamedThing lytic transglycosylase activity Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. got7fsn_ti peptidoglycan lytic transglycosylase activity|murein transglycosylase B activity EC:3.2.1.- molecular_function owl:Class
GO:0039563 biolink:NamedThing suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1). got7fsn_ti inhibition by virus of host STAT1 activity|inhibition of host STAT1 by virus|suppression by virus of host STAT1 activity https://github.com/geneontology/go-ontology/issues/21963 This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. bf 2012-03-12T02:35:39Z biological_process owl:Class
GO:0039562 biolink:NamedThing suppression by virus of host JAK-STAT cascade via inhibition of STAT activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes. got7fsn_ti inhibition by virus of host STAT activity|suppression by virus of host signal transducer and activator of transcription activity|suppression by virus of host STAT activity https://github.com/geneontology/go-ontology/issues/21963 This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. bf 2012-03-12T02:28:39Z biological_process owl:Class
GO:1990710 biolink:NamedThing MutS complex A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations. got7fsn_ti MutS mismatch repair complex An example of this is MutS in E. coli (UniProt symbol P23909) in PMID:21666597 (inferred from physical interaction). bhm 2015-03-25T11:42:56Z cellular_component owl:Class
GO:0032300 biolink:NamedThing mismatch repair complex Any complex formed of proteins that act in mismatch repair. got7fsn_ti cellular_component owl:Class
GO:0008463 biolink:NamedThing formylmethionine deformylase activity Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate. got7fsn_ti N-formyl-L-methionine amidohydrolase activity EC:3.5.1.31|RHEA:17781|MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN|KEGG_REACTION:R00653 molecular_function owl:Class
GO:0018614 biolink:NamedThing ethylbenzene dioxygenase activity Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene. got7fsn_ti UM-BBD_reactionID:r0247|EC:1.14.12.- molecular_function owl:Class
GO:0044101 biolink:NamedThing (R)-citramalyl-CoA lyase activity Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA. got7fsn_ti R-citramalyl-CoA lyase activity|Ccl jl 2009-07-09T03:14:15Z EC:4.1.3.46|MetaCyc:RXN-8967 molecular_function owl:Class
GO:0008888 biolink:NamedThing glycerol dehydrogenase [NAD+] activity Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH. got7fsn_ti glycerol dehydrogenase activity|NAD-linked glycerol dehydrogenase activity RHEA:13769|MetaCyc:GLYCDEH-RXN|EC:1.1.1.6|KEGG_REACTION:R01034 molecular_function owl:Class
GO:1990042 biolink:NamedThing glycerol dehydrogenase [NAD(P)+] activity Catalysis of an oxidation-reduction (redox) reaction in which glycerol is converted into glycerone and NAD+ or NADP is reduced. got7fsn_ti glycerol dehydrogenase activity, NAD or NADP as acceptor rb 2013-02-14T00:34:45Z molecular_function owl:Class
GO:0003285 biolink:NamedThing septum secundum development The progression of the septum secundum over time, from its initial formation to the mature structure. got7fsn_ti dph 2009-10-20T10:21:13Z biological_process owl:Class
GO:0003283 biolink:NamedThing atrial septum development The progression of the atrial septum over time, from its initial formation to the mature structure. got7fsn_ti dph 2009-10-20T10:10:38Z biological_process owl:Class
GO:0019595 biolink:NamedThing non-phosphorylated glucose catabolic process The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose. got7fsn_ti non-phosphorylated glucose breakdown|non-phosphorylated glucose catabolism|non-phosphorylated glucose degradation MetaCyc:NPGLUCAT-PWY biological_process owl:Class
GO:0046430 biolink:NamedThing non-phosphorylated glucose metabolic process The chemical reactions and pathways involving non-phosphorylated forms of glucose. got7fsn_ti non-phosphorylated glucose metabolism biological_process owl:Class
GO:0050608 biolink:NamedThing vanillin dehydrogenase activity Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate. got7fsn_ti vanillin:NAD+ oxidoreductase activity MetaCyc:1.2.1.67-RXN|RHEA:13309|KEGG_REACTION:R05699|EC:1.2.1.67 molecular_function owl:Class
GO:0030677 biolink:NamedThing ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. got7fsn_ti RNase P complex Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA. cellular_component owl:Class
GO:0080165 biolink:NamedThing callose deposition in phloem sieve plate Any process in which callose is transported to, and/or maintained in, phloem sieve plate. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. got7fsn_ti dhl 2010-09-23T04:12:49Z biological_process owl:Class
GO:0004056 biolink:NamedThing argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. got7fsn_ti arginine-succinate lyase activity|argininosuccinic acid lyase activity|arginosuccinase activity|omega-N-(L-arginino)succinate arginine-lyase activity|N-(L-argininosuccinate) arginine-lyase activity|2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)|2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming) EC:4.3.2.1|MetaCyc:ARGSUCCINLYA-RXN|RHEA:24020|Reactome:R-HSA-70573 molecular_function owl:Class
GO:0070880 biolink:NamedThing fungal-type cell wall beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. got7fsn_ti fungal-type cell wall beta-glucan anabolism|fungal-type cell wall beta-glucan synthesis|fungal-type cell wall beta-glucan formation|fungal-type cell wall beta-glucan biosynthesis mah 2009-08-21T02:48:24Z biological_process owl:Class
GO:0051278 biolink:NamedThing fungal-type cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall. got7fsn_ti chitin- and beta-glucan-containing cell wall polysaccharide biosynthetic process|cell wall polysaccharide synthesis|cell wall polysaccharide anabolism|cell wall polysaccharide formation biological_process owl:Class
GO:0071224 biolink:NamedThing cellular response to peptidoglycan Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. got7fsn_ti mah 2009-12-03T01:36:38Z biological_process owl:Class
GO:0071219 biolink:NamedThing cellular response to molecule of bacterial origin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. got7fsn_ti cellular response to bacterial associated molecule|cellular response to bacteria associated molecule|cellular response to bacterium associated molecule mah 2009-12-03T01:22:00Z biological_process owl:Class
GO:0070446 biolink:NamedThing negative regulation of oligodendrocyte progenitor proliferation Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation. got7fsn_ti negative regulation of oligodendrocyte precursor proliferation biological_process owl:Class
GO:0014014 biolink:NamedThing negative regulation of gliogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia. got7fsn_ti inhibition of gliogenesis|down regulation of gliogenesis|downregulation of gliogenesis|down-regulation of gliogenesis biological_process owl:Class
GO:1900557 biolink:NamedThing emericellamide biosynthetic process The chemical reactions and pathways resulting in the formation of emericellamide. got7fsn_ti emericellamide biosynthesis|emericellamide synthesis|emericellamide anabolism|emericellamide formation di 2012-05-15T01:33:31Z biological_process owl:Class
GO:0061107 biolink:NamedThing seminal vesicle development The progression of the seminal vesicle over time, from its formation to the mature structure. The seminal vesicle is a gland that contributes to the production of semen. got7fsn_ti dph 2010-04-30T10:17:30Z biological_process owl:Class
GO:0008700 biolink:NamedThing 4-hydroxy-2-oxoglutarate aldolase activity Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. got7fsn_ti 4-hydroxy-2-ketoglutarate aldolase activity|2-keto-4-hydroxybutyrate aldolase activity|2-keto-4-hydroxyglutaric aldolase activity|4-hydroxy-2-ketoglutaric aldolase activity|4-hydroxy-2-oxoglutarate glyoxylate-lyase activity|KHG-aldolase activity|hydroxyketoglutarate aldolase activity|DL-4-hydroxy-2-ketoglutarate aldolase activity|2-oxo-4-hydroxyglutaric aldolase activity|hydroxyketoglutaric aldolase activity|4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)|2-keto-4-hydroxyglutarate aldolase activity|2-oxo-4-hydroxyglutarate aldolase activity EC:4.1.3.16|RHEA:18169|Reactome:R-HSA-6784423|MetaCyc:4OH2OXOGLUTARALDOL-RXN molecular_function owl:Class
GO:0080189 biolink:NamedThing primary growth Growth of a plant structure from the time of its initiation by an apical meristem until its expansion is completed. got7fsn_ti Has its inception in the apical meristems (PO:0020144) and continues in their derivative meristems - protoderm (PO:0006210) and procambium (PO:0025275) - even in older tissues. Primary and secondary growth can occur simultaneously in the same organism. dhl 2012-12-06T15:20:41Z biological_process owl:Class
GO:0008428 biolink:NamedThing ribonuclease inhibitor activity Binds to and stops, prevents or reduces the activity of ribonuclease. got7fsn_ti molecular_function owl:Class
GO:0009062 biolink:NamedThing fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. got7fsn_ti fatty acid catabolism|fatty acid degradation|fatty acid breakdown Wikipedia:Fatty_acid_degradation biological_process owl:Class
GO:0021762 biolink:NamedThing substantia nigra development The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis). got7fsn_ti biological_process owl:Class
GO:0021928 biolink:NamedThing basket cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0021923 biolink:NamedThing cell proliferation in hindbrain ventricular zone The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity. got7fsn_ti biological_process owl:Class
GO:0080046 biolink:NamedThing quercetin 4'-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 4'-hydroxy group of a quercetin molecule. got7fsn_ti MetaCyc:RXN-10788 molecular_function owl:Class
GO:0052482 biolink:NamedThing defense response by cell wall thickening A type of cell wall modification, in which the cell wall is reinforced and made thicker, that occurs as part of the defense response of an organism. got7fsn_ti cell wall thickening during defense response biological_process owl:Class
GO:0017007 biolink:NamedThing protein-bilin linkage The covalent linkage of bilin and a protein. got7fsn_ti biological_process owl:Class
GO:0031142 biolink:NamedThing induction of conjugation upon nitrogen starvation The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation. got7fsn_ti biological_process owl:Class
GO:0097232 biolink:NamedThing lamellar body membrane The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome. got7fsn_ti pr 2012-01-26T10:28:42Z cellular_component owl:Class
GO:0009585 biolink:NamedThing red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. got7fsn_ti phytochrome signaling pathway|red-sensitive opsin biological_process owl:Class
GO:0032625 biolink:NamedThing interleukin-21 production The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-21 production|interleukin-21 biosynthetic process|interleukin-21 secretion GO:0042238|GO:0072619 biological_process owl:Class
GO:0097581 biolink:NamedThing lamellipodium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments. got7fsn_ti pr 2014-02-28T16:08:56Z biological_process owl:Class
GO:0030030 biolink:NamedThing cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon. got7fsn_ti cell surface structure organization and biogenesis|cell projection organization and biogenesis|cell projection organisation biological_process owl:Class
GO:0005575 biolink:NamedThing cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). got7fsn_ti subcellular entity|cell or subcellular entity|cellular component Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. GO:0008372 NIF_Subcellular:sao1337158144 cellular_component owl:Class
GO:0102838 biolink:NamedThing 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8298|EC:1.14.19.23 molecular_function owl:Class
GO:0018131 biolink:NamedThing oxazole or thiazole biosynthetic process The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position. got7fsn_ti oxazole or thiazole synthesis|oxazole or thiazole formation|oxazole or thiazole anabolism|oxazole or thiazole biosynthesis biological_process owl:Class
GO:0018130 biolink:NamedThing heterocycle biosynthetic process The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). got7fsn_ti heterocycle biosynthesis|heterocycle formation|heterocycle anabolism|heterocycle synthesis biological_process owl:Class
GO:0035006 biolink:NamedThing melanization defense response The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin. got7fsn_ti melanization defence response biological_process owl:Class
GO:0006582 biolink:NamedThing melanin metabolic process The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. got7fsn_ti melanin metabolism biological_process owl:Class
GO:0140493 biolink:NamedThing very long-chain fatty acid beta-oxidation A fatty acid beta-oxidation pathway acting on fatty acid which has a chain length greater than C22 in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti https://github.com/geneontology/go-ontology/issues/19735 pg 2020-07-10T08:39:22Z biological_process owl:Class
GO:0042760 biolink:NamedThing very long-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22. got7fsn_ti very-long-chain fatty acid catabolic process|very-long-chain fatty acid catabolism|very-long-chain fatty acid degradation|very-long-chain fatty acid breakdown biological_process owl:Class
GO:0035367 biolink:NamedThing positive regulation of thymine transport Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti positive regulation of 5-methyluracil transport bf 2010-03-11T10:24:25Z biological_process owl:Class
GO:0032241 biolink:NamedThing positive regulation of nucleobase-containing compound transport Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|activation of nucleobase, nucleoside, nucleotide and nucleic acid transport|up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport biological_process owl:Class
GO:0046029 biolink:NamedThing mannitol dehydrogenase activity Catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH. got7fsn_ti MTD activity|NAD-dependent mannitol dehydrogenase activity|mannitol:NAD+ 1-oxidoreductase activity RHEA:15029|MetaCyc:1.1.1.255-RXN|EC:1.1.1.255|KEGG_REACTION:R07135 molecular_function owl:Class
GO:0052390 biolink:NamedThing induction by symbiont of host innate immune response The activation by a symbiont of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation of host innate immune response|activation by organism of host innate immune response|activation by symbiont of host innate immunity|stimulation by symbiont of host innate immunity|up regulation by symbiont of host innate immunity|positive regulation of innate immune response in other organism|induction of host innate immunity|up-regulation by symbiont of host innate immunity|induction by organism of host innate immune response|induction by organism of innate immune response in other organism involved in symbiotic interaction|positive regulation by symbiont of host innate immunity|upregulation by symbiont of host innate immunity|induction by symbiont of host innate immunity|activation by organism of host innate immunity|positive regulation by symbiont of host innate immune response GO:0052305|GO:0052166|GO:0052382 biological_process owl:Class
GO:0042074 biolink:NamedThing cell migration involved in gastrulation The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). got7fsn_ti biological_process owl:Class
GO:0106059 biolink:NamedThing tRNA (cytidine 56-2'-O)-methyltransferase Catalysis of the reaction: S-adenosyl-L-methionine + cytidine56 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine56 in tRNA. got7fsn_ti hjd 2017-10-05T19:02:22Z molecular_function owl:Class
GO:0052666 biolink:NamedThing tRNA (cytosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylcytosine. got7fsn_ti S-adenosyl-L-methionine:tRNA (cytosine-2'-O-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA cytosine-2'-O-methyltransferase activity|transfer ribonucleate cytosine 2'-methyltransferase activity|tRNA cytosine 2'-methyltransferase activity|tRNA (cytosine 2')-methyltransferase activity|tRNA cytosine-2'-O-methyltransferase activity ai 2010-10-11T01:05:47Z Reactome:R-HSA-6788684|MetaCyc:RXN0-5143|Reactome:R-HSA-9024159|Reactome:R-HSA-6788668 molecular_function owl:Class
GO:0060088 biolink:NamedThing auditory receptor cell stereocilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of auditory hair cells. got7fsn_ti auditory receptor cell stereocilium organization and biogenesis|auditory receptor cell stereocilium organisation biological_process owl:Class
GO:0060122 biolink:NamedThing inner ear receptor cell stereocilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells. got7fsn_ti inner ear receptor stereocilium organisation|inner ear hair cell receptor stereocilium organization|inner ear receptor stereocilium organization and biogenesis biological_process owl:Class
GO:0015234 biolink:NamedThing thiamine transmembrane transporter activity Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. got7fsn_ti thiamine uptake transmembrane transporter activity|thiamin transmembrane transporter activity|thiamin permease activity|thiamin uptake transporter activity|vitamin B1 transporter activity|thiamine permease activity GO:0015403|GO:0015402 RHEA:34919|Reactome:R-HSA-199626 molecular_function owl:Class
GO:0018310 biolink:NamedThing protein-FMN linkage via S-(6-FMN)-L-cysteine The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine. got7fsn_ti RESID:AA0220 biological_process owl:Class
GO:0043469 biolink:NamedThing regulation of D-xylose catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose. got7fsn_ti biological_process owl:Class
GO:0043471 biolink:NamedThing regulation of cellular carbohydrate catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells. got7fsn_ti biological_process owl:Class
GO:1990724 biolink:NamedThing galectin complex A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes. got7fsn_ti galectin-2 complex|galectin-1 complex An example of this is Galectin-1 in human (P09382) in PMID:15476813 (inferred from physical interaction). bhm 2015-04-07T15:03:15Z cellular_component owl:Class
GO:0048254 biolink:NamedThing snoRNA localization Any process in which small nucleolar RNA is transported to, or maintained in, a specific location. got7fsn_ti small nucleolar RNA localization|snoRNA localisation|establishment and maintenance of snoRNA localization biological_process owl:Class
GO:0006403 biolink:NamedThing RNA localization A process in which RNA is transported to, or maintained in, a specific location. got7fsn_ti establishment and maintenance of RNA localization|RNA localisation biological_process owl:Class
GO:0022873 biolink:NamedThing protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti maltose PTS transporter activity molecular_function owl:Class
GO:0005363 biolink:NamedThing maltose transmembrane transporter activity Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. got7fsn_ti maltose porter activity GO:0015581 RHEA:33171 molecular_function owl:Class
GO:0005338 biolink:NamedThing nucleotide-sugar transmembrane transporter activity Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. got7fsn_ti GO:0005339 Reactome:R-HSA-744230|Reactome:R-HSA-744231 molecular_function owl:Class
GO:0042138 biolink:NamedThing meiotic DNA double-strand break formation The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination. got7fsn_ti biological_process owl:Class
GO:0090305 biolink:NamedThing nucleic acid phosphodiester bond hydrolysis The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis. got7fsn_ti nucleic acid cleavage tb 2010-04-07T10:26:30Z biological_process owl:Class
GO:0060199 biolink:NamedThing clathrin-sculpted glutamate transport vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing glutamate. got7fsn_ti clathrin sculpted glutamate transport vesicle|clathrin sculpted glutamate constitutive secretory pathway transport vesicle cellular_component owl:Class
GO:0080008 biolink:NamedThing Cul4-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. got7fsn_ti cellular_component owl:Class
GO:0046893 biolink:NamedThing iron incorporation into hydrogenase diiron subcluster via L-cysteine ligation The incorporation of iron into an L-cysteinyl diiron subcluster, found in Fe-hydrogenase. got7fsn_ti RESID:AA0334 biological_process owl:Class
GO:0021743 biolink:NamedThing hypoglossal nucleus development The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0007379 biolink:NamedThing segment specification The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes. got7fsn_ti biological_process owl:Class
GO:0033979 biolink:NamedThing box H/ACA RNA metabolic process The chemical reactions and pathways involving box H/ACA type small nucleolar RNA. got7fsn_ti box H/ACA sRNA metabolic process|box H/ACA snoRNA metabolic process https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0016074 biolink:NamedThing sno(s)RNA metabolic process The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA. got7fsn_ti box C/D sRNA metabolic process|snoRNA metabolism biological_process owl:Class
GO:0007156 biolink:NamedThing homophilic cell adhesion via plasma membrane adhesion molecules The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell. got7fsn_ti biological_process owl:Class
GO:0014076 biolink:NamedThing response to fluoxetine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor. got7fsn_ti response to selective serotonin reuptake inhibitor|response to SSRI Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0036276 biolink:NamedThing response to antidepressant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. bf 2012-07-09T02:12:44Z biological_process owl:Class
GO:0106351 biolink:NamedThing aspartate dehydrogenase NAD activity Catalysis of the reaction: L-aspartate + H2O + NAD+ = oxaloacetate + NH3 + NADH+ H+. got7fsn_ti hjd 2021-01-20T17:39:50Z RHEA:11788 molecular_function owl:Class
GO:0033735 biolink:NamedThing aspartate dehydrogenase activity Catalysis of the reaction: L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+. got7fsn_ti L-aspartate:NAD(P)+ oxidoreductase (deaminating) activity|NADH2-dependent aspartate dehydrogenase activity|NADP+-dependent aspartate dehydrogenase activity|NAD-dependent aspartate dehydrogenase activity MetaCyc:1.4.1.21-RXN|KEGG_REACTION:R07165|EC:1.4.1.21|KEGG_REACTION:R07164 molecular_function owl:Class
GO:0002501 biolink:NamedThing peptide antigen assembly with MHC protein complex The binding of a peptide to the antigen binding groove of an MHC protein complex. got7fsn_ti biological_process owl:Class
GO:0048688 biolink:NamedThing negative regulation of sprouting of injured axon Any process that stops, prevents, or reduces the frequency, rate or extent of sprouting of an injured axon. got7fsn_ti down regulation of sprouting of injured axon|downregulation of sprouting of injured axon|down-regulation of sprouting of injured axon|inhibition of sprouting of injured axon biological_process owl:Class
GO:0048681 biolink:NamedThing negative regulation of axon regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration. got7fsn_ti downregulation of axon regeneration|down-regulation of axon regeneration|down regulation of axon regeneration|inhibition of axon regeneration biological_process owl:Class
GO:0016781 biolink:NamedThing phosphotransferase activity, paired acceptors Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors. got7fsn_ti EC:2.7.9.- molecular_function owl:Class
GO:0003421 biolink:NamedThing growth plate cartilage axis specification The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth. got7fsn_ti growth plate cartilage axis determination dph 2009-12-22T09:16:33Z biological_process owl:Class
GO:0044847 biolink:NamedThing iron acquisition from host The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell. got7fsn_ti acquisition by organism of nutrients from host via siderophores|iron acquisition|iron acquisition by symbiont from host heme|acquisition by symbiont of nutrients from host via siderophores|heme acquisition|iron acquisition by symbiont from host https://github.com/geneontology/go-ontology/issues/17896 jl 2014-05-13T13:40:59Z GO:0052099 biological_process owl:Class
GO:0044002 biolink:NamedThing acquisition of nutrients from host The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0016335 biolink:NamedThing morphogenesis of larval imaginal disc epithelium The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized. got7fsn_ti biological_process owl:Class
GO:0044177 biolink:NamedThing host cell Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. got7fsn_ti host Golgi apparatus jl 2009-09-04T03:14:38Z cellular_component owl:Class
GO:0000947 biolink:NamedThing amino acid catabolic process to alcohol via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. got7fsn_ti biological_process owl:Class
GO:0044632 biolink:NamedThing negative regulation of complement activation, lectin pathway in other organism Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism. got7fsn_ti jl 2012-07-05T01:18:43Z biological_process owl:Class
GO:2000134 biolink:NamedThing negative regulation of G1/S transition of mitotic cell cycle Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. got7fsn_ti mah 2010-09-29T09:38:51Z biological_process owl:Class
GO:0031021 biolink:NamedThing interphase microtubule organizing center A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus. got7fsn_ti interphase microtubule organising center|iMTOC|interphase MTOC cellular_component owl:Class
GO:0043060 biolink:NamedThing meiotic metaphase I plate congression The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I. got7fsn_ti biological_process owl:Class
GO:0036036 biolink:NamedThing cardiac neural crest cell delamination The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube. got7fsn_ti bf 2011-11-02T05:23:29Z biological_process owl:Class
GO:0036032 biolink:NamedThing neural crest cell delamination The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube. got7fsn_ti neural crest cell emigration|neural crest cell individualization|neural crest cell segregation bf 2011-10-31T03:50:30Z biological_process owl:Class
GO:0044377 biolink:NamedThing RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. got7fsn_ti RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II proximal promoter region sequence-specific DNA binding, bending|RNA polymerase II promoter proximal region sequence-specific DNA binding, bending|RNA polymerase II proximal promoter sequence-specific DNA binding, bending jl 2011-12-08T01:38:21Z molecular_function owl:Class
GO:0044374 biolink:NamedThing sequence-specific DNA binding, bending The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. got7fsn_ti DNA bending involving sequence-specific DNA binding jl 2011-12-01T04:05:59Z molecular_function owl:Class
GO:0052923 biolink:NamedThing all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate. got7fsn_ti SPP synthase activity|SPP-synthase activity|solPP synthase activity|nonaprenyl diphosphate synthase activity|solanesyl-diphosphate synthase activity|solanesyl diphosphate synthetase activity MetaCyc:TRANS-OCTAPRENYLTRANSTRANSFERASE-RXN|EC:2.5.1.84|RHEA:27563|KEGG_REACTION:R09250 molecular_function owl:Class
GO:0019884 biolink:NamedThing antigen processing and presentation of exogenous antigen The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex. got7fsn_ti antigen presentation, exogenous antigen biological_process owl:Class
GO:0035867 biolink:NamedThing alphav-beta3 integrin-IGF-1-IGF1R complex A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits. got7fsn_ti bf 2011-05-25T03:06:30Z cellular_component owl:Class
GO:0043207 biolink:NamedThing response to external biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things. got7fsn_ti biological_process owl:Class
GO:0061457 biolink:NamedThing mesonephric cell migration involved in male gonad development The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development. got7fsn_ti dph 2012-08-22T17:31:00Z biological_process owl:Class
GO:0033425 biolink:NamedThing CAU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAU codon. got7fsn_ti histidine tRNA|CAT codon-amino acid adaptor activity Note that in the standard genetic code, CAT codes for histidine. molecular_function owl:Class
GO:0000482 biolink:NamedThing maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0000481 biolink:NamedThing maturation of 5S rRNA Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0003122 biolink:NamedThing norepinephrine-mediated vasodilation A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings. got7fsn_ti regulation of vasodilation by circulating noradrenaline|regulation of vasodilation by circulating norepinephrine|regulation of vasodilation by neuronal norepinephrine|regulation of vasodilation by neuronal noradrenaline|regulation of vasodilation by norepinephrine|regulation of vasodilation by noradrenaline GO:0003126|GO:0003125 biological_process owl:Class
GO:2000360 biolink:NamedThing negative regulation of binding of sperm to zona pellucida Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida. got7fsn_ti negative regulation of ZPG binding yaf 2011-02-03T02:42:54Z biological_process owl:Class
GO:0031859 biolink:NamedThing platelet activating factor receptor binding Binding to a platelet activating factor receptor. got7fsn_ti platelet activating factor receptor ligand molecular_function owl:Class
GO:0002228 biolink:NamedThing natural killer cell mediated immunity The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines. got7fsn_ti NK cell mediated immunity biological_process owl:Class
GO:0002449 biolink:NamedThing lymphocyte mediated immunity Any process involved in the carrying out of an immune response by a lymphocyte. got7fsn_ti cell-mediated immunity|cellular immune response biological_process owl:Class
GO:0032357 biolink:NamedThing oxidized purine DNA binding Binding to a DNA region containing an oxidized purine residue. got7fsn_ti oxidized purine nucleobase DNA binding|oxidized purine base DNA binding|oxidised purine DNA binding molecular_function owl:Class
GO:0030564 biolink:NamedThing tRNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0030561 biolink:NamedThing RNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0047012 biolink:NamedThing sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity Catalysis of the reaction: NAD(P)+ + 3-beta-hydroxy-4-alpha-methyl-5-alpha-cholest-7-ene-4-beta-carboxylate = NAD(P)H + H+ + CO2 + 4-alpha-methyl-5-alpha-cholest-7-en-3-one. got7fsn_ti 3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity|3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase activity|3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) activity|sterol 4-alpha-carboxylic decarboxylase activity|3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) MetaCyc:1.1.1.170-RXN|EC:1.1.1.170 molecular_function owl:Class
GO:1990728 biolink:NamedThing mitotic spindle assembly checkpoint MAD1-MAD2 complex A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex. got7fsn_ti MAD1-MAD2 complex An example of this is MAD1 in human (Q9Y6D9) in PMID:12006501 (inferred from physical interaction). bhm 2015-04-15T10:14:17Z cellular_component owl:Class
GO:0019938 biolink:NamedThing peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions. got7fsn_ti GO:0042266 RESID:AA0294 biological_process owl:Class
GO:0018420 biolink:NamedThing peptide cross-linking via N6-(L-isoaspartyl)-L-lysine The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues. got7fsn_ti RESID:AA0294 biological_process owl:Class
GO:0007299 biolink:NamedThing ovarian follicle cell-cell adhesion The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster. got7fsn_ti ovarian follicle cell adhesion|follicle cell adhesion biological_process owl:Class
GO:0044501 biolink:NamedThing modulation of signal transduction in other organism The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism. got7fsn_ti jl 2012-02-23T03:48:19Z biological_process owl:Class
GO:0047452 biolink:NamedThing protoaphin-aglucone dehydratase (cyclizing) activity Catalysis of the reaction: protoaphin aglucone = H(2)O + xanthoaphin. got7fsn_ti protoaphin dehydratase (cyclizing)|protoaphin dehydratase activity|protoaphin-aglucone hydro-lyase (cyclizing; xanthoaphin-forming)|protoaphin-aglucone hydro-lyase (cyclizing) RHEA:23876|EC:4.2.1.73|MetaCyc:4.2.1.73-RXN|KEGG_REACTION:R03742 molecular_function owl:Class
GO:1903318 biolink:NamedThing negative regulation of protein maturation Any process that stops, prevents or reduces the frequency, rate or extent of protein maturation. got7fsn_ti down regulation of protein maturation|inhibition of protein maturation|downregulation of protein maturation|down-regulation of protein maturation vw 2014-08-18T12:59:15Z biological_process owl:Class
GO:0016934 biolink:NamedThing extracellularly glycine-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. got7fsn_ti glycine-inhibited chloride channel activity|glycine receptor|extracellular-glycine-gated chloride channel activity GO:0004891 Reactome:R-HSA-975389 molecular_function owl:Class
GO:0016933 biolink:NamedThing extracellularly glycine-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. got7fsn_ti extracellular-glycine-gated ion channel activity|glycine receptor molecular_function owl:Class
GO:0060071 biolink:NamedThing Wnt signaling pathway, planar cell polarity pathway The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity. got7fsn_ti Wnt receptor signalling pathway, planar cell polarity pathway|Wnt receptor signaling pathway, planar cell polarity pathway|Wnt-JNK signaling pathway|non-canonical Wnt signaling pathway|Wnt-PCP signaling pathway|planar cell polarity pathway|Wnt-activated signaling pathway, planar cell polarity pathway|PCP pathway biological_process owl:Class
GO:0035198 biolink:NamedThing miRNA binding Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. got7fsn_ti microRNA binding molecular_function owl:Class
GO:1990931 biolink:NamedThing mRNA N6-methyladenosine dioxygenase activity Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde. got7fsn_ti RNA N6-methyladenosine dioxygenase activity|mRNA N(6)-methyladenine demethylase|mRNA N(6)-methyladenosine dioxygenase activity https://github.com/geneontology/go-ontology/issues/21812 sp 2016-03-10T08:10:10Z RHEA:49520|EC:1.14.11.53 molecular_function owl:Class
GO:0035515 biolink:NamedThing oxidative RNA demethylase activity Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. got7fsn_ti 2-oxoglutarate-dependent RNA demethylase https://github.com/geneontology/go-ontology/issues/21160 bf 2010-04-30T02:37:08Z Reactome:R-HSA-8857692 molecular_function owl:Class
GO:0004905 biolink:NamedThing type I interferon receptor activity Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. got7fsn_ti interferon-delta receptor activity|type I IFN receptor activity|interferon-beta receptor activity|interferon-alpha/beta receptor activity|interferon-zeta receptor activity|interferon-alpha receptor activity|interferon-tau receptor activity|interferon-kappa receptor activity|interferon-omega receptor activity|interferon-epsilon receptor activity molecular_function owl:Class
GO:0004904 biolink:NamedThing interferon receptor activity Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IFN receptor activity molecular_function owl:Class
GO:0070900 biolink:NamedThing mitochondrial tRNA modification The covalent alteration of one or more nucleotides within a mitochondrial tRNA molecule to produce a mitochondrial tRNA molecule with a sequence that differs from that coded genetically. got7fsn_ti mah 2009-09-02T03:16:53Z biological_process owl:Class
GO:0070525 biolink:NamedThing tRNA threonylcarbamoyladenosine metabolic process The chemical reactions and pathways involving tRNA threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. got7fsn_ti t6A metabolism|threonylcarbamoyladenosine metabolism|t6A metabolic process biological_process owl:Class
GO:0075016 biolink:NamedThing appressorium formation The process in which a swollen, flattened portion of a symbiont filament is formed on or near its host organism, to adhere to and for the purpose of penetrating the host surface. got7fsn_ti formation of an appressorium by symbiont on or near host|appressorium formation on or near host|appressorium formation for entry into host, on or near host biological_process owl:Class
GO:0032600 biolink:NamedThing chemokine receptor transport out of membrane raft The directed movement of a chemokine receptor out of a membrane raft. got7fsn_ti chemokine receptor translocation out of membrane raft|chemokine receptor transport out of lipid raft biological_process owl:Class
GO:0032599 biolink:NamedThing protein transport out of membrane raft The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. got7fsn_ti protein translocation out of membrane raft|protein transport out of lipid raft|receptor transport out of membrane raft|receptor translocation out of membrane raft biological_process owl:Class
GO:0072262 biolink:NamedThing metanephric glomerular mesangial cell proliferation involved in metanephros development The multiplication or reproduction of glomerular mesangial cells in the metanephros, resulting in the expansion of the population. got7fsn_ti mah 2010-03-30T02:27:27Z biological_process owl:Class
GO:0072110 biolink:NamedThing glomerular mesangial cell proliferation The multiplication or reproduction of glomerular mesangial cells, resulting in the expansion of the population. got7fsn_ti mah 2010-02-22T10:45:47Z biological_process owl:Class
GO:0070975 biolink:NamedThing FHA domain binding Binding to a FHA domain of a protein. The FHA domain is a phosphopeptide recognition domain found in many regulatory proteins, and consists of approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich. got7fsn_ti Forkhead-associated domain binding mah 2009-10-02T01:09:20Z molecular_function owl:Class
GO:0004779 biolink:NamedThing sulfate adenylyltransferase activity Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate. got7fsn_ti sulphate adenylyltransferase activity molecular_function owl:Class
GO:0006526 biolink:NamedThing arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. got7fsn_ti arginine anabolism|arginine formation|arginine biosynthesis|arginine synthesis MetaCyc:ARGSYN-PWY|MetaCyc:ARGININE-SYN4-PWY|MetaCyc:ARGSYNBSUB-PWY biological_process owl:Class
GO:0009084 biolink:NamedThing glutamine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. got7fsn_ti glutamine family amino acid formation|glutamine family amino acid biosynthesis|glutamine family amino acid synthesis|glutamine family amino acid anabolism biological_process owl:Class
GO:0035599 biolink:NamedThing aspartic acid methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid. got7fsn_ti Note that peptidyl-L-beta-methylthioaspartic acid is typical of bacterial ribosomal protein S12. bf 2010-11-12T01:31:23Z RESID:AA0232 molecular_function owl:Class
GO:0045334 biolink:NamedThing clathrin-coated endocytic vesicle A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. got7fsn_ti NIF_Subcellular:sao1243595998 cellular_component owl:Class
GO:0018117 biolink:NamedThing protein adenylylation The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid. got7fsn_ti protein adenylation|protein AMPylation|protein amino acid adenylylation GO:0018176 biological_process owl:Class
GO:0030692 biolink:NamedThing Noc4p-Nop14p complex A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis. got7fsn_ti Nop7 complex|Nop7 subcomplex Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654' and/or 'nuclear pore ; GO:0005643'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. cellular_component owl:Class
GO:0030689 biolink:NamedThing Noc complex Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis. got7fsn_ti Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found. cellular_component owl:Class
GO:0071456 biolink:NamedThing cellular response to hypoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. got7fsn_ti cellular response to lowered oxygen tension|cellular response to hypoxic stress Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. mah 2009-12-16T04:45:20Z biological_process owl:Class
GO:0102865 biolink:NamedThing delta6-acyl-lipid desaturase activity Catalysis of the reaction: a gamma-linolenoyl-[glycerolipid] + 2 ferrocytochrome b5 + O(2) + 2 H(+) <=> a (9Z,12Z)-octadeca-9,12-dien-6-ynoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H(2)O. got7fsn_ti MetaCyc:RXN-8343|EC:1.14.19.38|RHEA:46536 molecular_function owl:Class
GO:0019498 biolink:NamedThing n-octane oxidation The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA. got7fsn_ti MetaCyc:P221-PWY biological_process owl:Class
GO:0018939 biolink:NamedThing n-octane metabolic process The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System. got7fsn_ti n-octane metabolism UM-BBD_pathwayID:oct biological_process owl:Class
GO:0030926 biolink:NamedThing calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site. got7fsn_ti RESID:AA0366 biological_process owl:Class
GO:0030925 biolink:NamedThing calcium incorporation into metallo-oxygen cluster The incorporation of calcium into a metallo-oxygen cluster. got7fsn_ti biological_process owl:Class
GO:0043773 biolink:NamedThing coenzyme F420-0 gamma-glutamyl ligase activity Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates. got7fsn_ti F420-0 gamma-glutamyl ligase activity molecular_function owl:Class
GO:0039628 biolink:NamedThing T=169 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins. got7fsn_ti T=169 icosahedral capsid bf 2012-08-03T16:27:55Z cellular_component owl:Class
GO:0140622 biolink:NamedThing ER-to-endosome phospholipid transfer complex Lipid transfer complex that is responsible for the non-vesicular transport of phospholipids, such as phosphatidylserine, from the endoplasmic reticulum to the endosome. It resides in the endosomal (acceptor) membrane and binds to specific lipids on the donor membrane at the ER-endosome contact site. got7fsn_ti https://github.com/geneontology/go-ontology/issues/15338 pg 2021-03-10T11:27:24Z cellular_component owl:Class
GO:0098796 biolink:NamedThing membrane protein complex Any protein complex that is part of a membrane. got7fsn_ti cellular_component owl:Class
GO:0036119 biolink:NamedThing response to platelet-derived growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus. got7fsn_ti response to platelet-derived growth factor stimulus|response to PDGF stimulus bf 2012-02-20T02:48:00Z biological_process owl:Class
GO:0007135 biolink:NamedThing meiosis II The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II. got7fsn_ti meiosis II nuclear division Wikipedia:Meiosis#Meiosis_II biological_process owl:Class
GO:0140013 biolink:NamedThing meiotic nuclear division One of the two nuclear divisions that occur as part of the meiotic cell cycle. got7fsn_ti meiosis https://github.com/geneontology/go-ontology/issues/19910 pg 2017-03-23T09:40:00Z biological_process owl:Class
GO:0038178 biolink:NamedThing complement component C5a signaling pathway A series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor. got7fsn_ti complement component C5a-induced signaling pathway bf 2012-09-21T10:55:00Z biological_process owl:Class
GO:0061327 biolink:NamedThing anterior Malpighian tubule development The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut. got7fsn_ti dph 2010-09-28T01:23:18Z biological_process owl:Class
GO:0140425 biolink:NamedThing galactose import across plasma membrane The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18788 pg 2020-02-10T08:46:09Z biological_process owl:Class
GO:0021536 biolink:NamedThing diencephalon development The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. got7fsn_ti biological_process owl:Class
GO:0000900 biolink:NamedThing translation repressor activity, mRNA regulatory element binding Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid. got7fsn_ti translation repressor activity, nucleic acid binding https://github.com/geneontology/go-ontology/issues/15049 molecular_function owl:Class
GO:0030371 biolink:NamedThing translation repressor activity Antagonizes ribosome-mediated translation of mRNA into a polypeptide. got7fsn_ti molecular_function owl:Class
GO:0032039 biolink:NamedThing integrator complex A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II. got7fsn_ti https://github.com/geneontology/go-ontology/issues/15979 cellular_component owl:Class
GO:0004698 biolink:NamedThing calcium-dependent protein kinase C activity Calcium-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. got7fsn_ti calcium-dependent PKC activity|conventional protein kinase C activity This reaction requires diacylglycerol and calcium. Reactome:R-HSA-114684|Reactome:R-HSA-114683|Reactome:R-HSA-421007|Reactome:R-HSA-416639|EC:2.7.11.13 molecular_function owl:Class
GO:0048344 biolink:NamedThing paraxial mesodermal cell fate determination The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0010198 biolink:NamedThing synergid death Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles. got7fsn_ti synergid degeneration|synergid cell death GO:0048470 biological_process owl:Class
GO:0051270 biolink:NamedThing regulation of cellular component movement Any process that modulates the frequency, rate or extent of the movement of a cellular component. got7fsn_ti regulation of cellular component motion|regulation of cell movement biological_process owl:Class
GO:0005462 biolink:NamedThing UDP-N-acetylglucosamine transmembrane transporter activity Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. got7fsn_ti Reactome:R-HSA-741450|Reactome:R-HSA-742354|Reactome:R-HSA-5653622 molecular_function owl:Class
GO:0004115 biolink:NamedThing 3',5'-cyclic-AMP phosphodiesterase activity Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. got7fsn_ti 3',5'-cyclic-AMP-specific phosphodiesterase activity|3',5' cAMP-specific phosphodiesterase activity|cyclic AMP-specific phosphodiesterase activity|cAMP-specific phosphodiesterase activity|adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity|3',5'-cAMP-specific phosphodiesterase activity Reactome:R-HSA-9644869|MetaCyc:RXN0-5038|RHEA:25277|EC:3.1.4.53|Reactome:R-HSA-9629675|Reactome:R-HSA-111962|Reactome:R-HSA-9705507|Reactome:R-HSA-418553 molecular_function owl:Class
GO:1990170 biolink:NamedThing stress response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus. got7fsn_ti stress response to cadmium|response to cadmium toxicity|response to cadmium ion stress pr 2013-08-14T12:55:45Z biological_process owl:Class
GO:0046686 biolink:NamedThing response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. got7fsn_ti response to cadmium|cadmium sensitivity/resistance biological_process owl:Class
GO:0033275 biolink:NamedThing actin-myosin filament sliding The sliding movement of actin thin filaments and myosin thick filaments past each other. got7fsn_ti actin filament sliding biological_process owl:Class
GO:0070252 biolink:NamedThing actin-mediated cell contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body. got7fsn_ti biological_process owl:Class
GO:1990074 biolink:NamedThing polyuridylation-dependent mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20568 tb 2013-04-16T22:51:46Z biological_process owl:Class
GO:0043632 biolink:NamedThing modification-dependent macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule. got7fsn_ti biological_process owl:Class
GO:0021662 biolink:NamedThing rhombomere 4 structural organization The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 4 structural organisation biological_process owl:Class
GO:0031839 biolink:NamedThing type 1 neuromedin U receptor binding Binding to a type 1 neuromedin U receptor. got7fsn_ti type 1 neuromedin U receptor ligand molecular_function owl:Class
GO:0000954 biolink:NamedThing methionine catabolic process to 3-methylthiopropanoate The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. got7fsn_ti biological_process owl:Class
GO:0000948 biolink:NamedThing amino acid catabolic process to carboxylic acid via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. got7fsn_ti biological_process owl:Class
GO:0070205 biolink:NamedThing 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Catalysis of the reaction: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-2-succinyl-6-hydroxycyclohexa-2,4-diene-1-carboxylate + pyruvate. got7fsn_ti 6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase activity|MenH|SHCHC synthase activity|YfbB|2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase activity EC:4.2.99.20|RHEA:25597|KEGG_REACTION:R08166|MetaCyc:RXN-9310 molecular_function owl:Class
GO:0016835 biolink:NamedThing carbon-oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond. got7fsn_ti other carbon-oxygen lyase activity EC:4.2.-.- molecular_function owl:Class
GO:0034178 biolink:NamedThing toll-like receptor 13 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 13. got7fsn_ti toll-like receptor 13 signalling pathway|TLR13 signaling pathway biological_process owl:Class
GO:0051302 biolink:NamedThing regulation of cell division Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. got7fsn_ti biological_process owl:Class
GO:0007197 biolink:NamedThing adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway|muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway|inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway biological_process owl:Class
GO:0047599 biolink:NamedThing 8-oxocoformycin reductase activity Catalysis of the reaction: coformycin + NADP(+) = 8-oxocoformycin + 2 H(+) + NADPH. got7fsn_ti coformycin:NADP+ 8-oxidoreductase activity|8-ketodeoxycoformycin reductase activity RHEA:23168|EC:1.1.1.235|MetaCyc:8-OXOCOFORMYCIN-REDUCTASE-RXN|KEGG_REACTION:R03667 molecular_function owl:Class
GO:0018708 biolink:NamedThing thiol S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether. got7fsn_ti S-adenosyl-L-methionine:thiol S-methyltransferase activity|TMT|thiol methyltransferase activity RHEA:18277|MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN|UM-BBD_enzymeID:e0146|Reactome:R-HSA-175976|EC:2.1.1.9 molecular_function owl:Class
GO:0030501 biolink:NamedThing positive regulation of bone mineralization Any process that activates or increases the frequency, rate or extent of bone mineralization. got7fsn_ti stimulation of bone mineralization|up regulation of bone mineralization|activation of bone mineralization|up-regulation of bone mineralization|upregulation of bone mineralization biological_process owl:Class
GO:0071346 biolink:NamedThing cellular response to interferon-gamma Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far. got7fsn_ti cellular response to type II interferon|cellular response to immune interferon|cellular response to gamma-interferon|cellular response to type II IFN mah 2009-12-11T02:48:00Z biological_process owl:Class
GO:0001825 biolink:NamedThing blastocyst formation The initial formation of a blastocyst from a solid ball of cells known as a morula. got7fsn_ti See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. biological_process owl:Class
GO:0071938 biolink:NamedThing vitamin A transport The directed movement any form of vitamin A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid. got7fsn_ti vitamin A uptake and transport mah 2010-09-30T04:15:10Z biological_process owl:Class
GO:0051180 biolink:NamedThing vitamin transport The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti vitamin or cofactor transport biological_process owl:Class
GO:0009989 biolink:NamedThing cell-matrix recognition Cell recognition that involves the interaction of the cell with the extracellular matrix. got7fsn_ti biological_process owl:Class
GO:0008037 biolink:NamedThing cell recognition The process in which a cell in an organism interprets its surroundings. got7fsn_ti recognition of surroundings by cell biological_process owl:Class
GO:1990715 biolink:NamedThing mRNA CDS binding Binding to an mRNA molecule coding sequence (CDS). got7fsn_ti mRNA coding region binding|mRNA coding sequence binding kmv 2015-03-27T20:59:49Z molecular_function owl:Class
GO:0046159 biolink:NamedThing ocellus pigment catabolic process The chemical reactions and pathways resulting in the breakdown of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. got7fsn_ti ocellus pigment degradation|ocellus pigment catabolism|ocellus pigment breakdown biological_process owl:Class
GO:0046149 biolink:NamedThing pigment catabolic process The chemical reactions and pathways resulting in the breakdown of a pigment, any general or particular coloring matter in living organisms, e.g. melanin. got7fsn_ti pigment degradation|pigment breakdown|pigment catabolism biological_process owl:Class
GO:0030849 biolink:NamedThing autosome Any chromosome other than a sex chromosome. got7fsn_ti Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. Wikipedia:Autosome cellular_component owl:Class
GO:0005694 biolink:NamedThing chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. got7fsn_ti prophase chromosome|chromatid|interphase chromosome Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. Wikipedia:Chromosome cellular_component owl:Class
GO:0090189 biolink:NamedThing regulation of branching involved in ureteric bud morphogenesis Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. got7fsn_ti tb 2009-12-18T11:11:17Z biological_process owl:Class
GO:0006932 biolink:NamedThing substrate-dependent cell migration, cell contraction The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves. got7fsn_ti substrate-bound cell migration, cell contraction biological_process owl:Class
GO:0060327 biolink:NamedThing cytoplasmic actin-based contraction involved in cell motility The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell from one place to another. got7fsn_ti biological_process owl:Class
GO:0050653 biolink:NamedThing chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate. got7fsn_ti chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process|chondroitin sulfate proteoglycan synthesis, polysaccharide chain synthesis|chondroitin sulfate proteoglycan chain elongation|chondroitin sulfate proteoglycan formation, polysaccharide chain biosynthesis|chondroitin sulfate proteoglycan formation, polysaccharide chain formation|chondroitin sulfate proteoglycan anabolism, polysaccharide chain anabolism|chondroitin sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis biological_process owl:Class
GO:0002778 biolink:NamedThing antibacterial peptide production The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0002775 biolink:NamedThing antimicrobial peptide production The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0030225 biolink:NamedThing macrophage differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. got7fsn_ti macrophage cell differentiation biological_process owl:Class
GO:0002573 biolink:NamedThing myeloid leukocyte differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage. got7fsn_ti myeloid leucocyte differentiation biological_process owl:Class
GO:0018079 biolink:NamedThing protein halogenation The addition of a halogen to a protein amino acid. got7fsn_ti protein amino acid halogenation biological_process owl:Class
GO:0018083 biolink:NamedThing peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases. got7fsn_ti peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine|peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine|peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine RESID:AA0185 biological_process owl:Class
GO:0047569 biolink:NamedThing 3-oxoadipate CoA-transferase activity Catalysis of the reaction: succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA. got7fsn_ti 3-oxoadipate succinyl-CoA transferase activity|beta-ketoadipate:succinyl-CoA transferase activity|succinyl-CoA:3-oxoadipate CoA-transferase activity|3-oxoadipate coenzyme A-transferase activity RHEA:12048|EC:2.8.3.6|UM-BBD_reactionID:r1050|MetaCyc:3-OXOADIPATE-COA-TRANSFERASE-RXN molecular_function owl:Class
GO:0050237 biolink:NamedThing pyridoxine 4-oxidase activity Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2. got7fsn_ti pyridoxin 4-oxidase activity|pyridoxine:oxygen 4-oxidoreductase activity|pyridoxol 4-oxidase activity MetaCyc:PYRIDOXINE-4-OXIDASE-RXN|RHEA:15033|EC:1.1.3.12 molecular_function owl:Class
GO:0072136 biolink:NamedThing metanephric mesenchymal cell proliferation involved in metanephros development The multiplication or reproduction of cells, resulting in the expansion of a metanephric mesenchymal cell population. got7fsn_ti mah 2010-02-22T02:34:56Z biological_process owl:Class
GO:0072203 biolink:NamedThing cell proliferation involved in metanephros development The multiplication or reproduction of cells, resulting in the expansion of the population in the metanephros. got7fsn_ti mah 2010-03-18T10:42:27Z biological_process owl:Class
GO:0072113 biolink:NamedThing head kidney development The process whose specific outcome is the progression of the head kidney over time, from its formation to the mature structure. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. It is analogous to the mammalian bone marrow and the primary site of definitive hematopoiesis. got7fsn_ti mah 2010-02-22T11:09:38Z biological_process owl:Class
GO:0048534 biolink:NamedThing hematopoietic or lymphoid organ development The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. got7fsn_ti hemopoietic or lymphoid organ development|haemopoietic or lymphoid organ development|haematopoietic or lymphoid organ development biological_process owl:Class
GO:0030791 biolink:NamedThing arsenite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate. got7fsn_ti S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity|S-adenosyl-L-methionine:arsenite As-methyltransferase activity|S-adenosyl-L-methionine:arsenic(III) methyltransferase activity Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792). Reactome:R-HSA-5696213|EC:2.1.1.137|Reactome:R-HSA-5696220|RHEA:15293|UM-BBD_reactionID:r0805|MetaCyc:2.1.1.137-RXN molecular_function owl:Class
GO:0038085 biolink:NamedThing vascular endothelial growth factor binding Binding to a vascular endothelial growth factor. got7fsn_ti VEGF binding bf 2012-02-01T02:36:36Z molecular_function owl:Class
GO:0036358 biolink:NamedThing lipoteichoic acid D-alanylation The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA). got7fsn_ti D-alanyl lipoteichoic acid formation|D-alanyl LTA formation|LTA D-alanylation bf 2012-09-19T15:09:05Z biological_process owl:Class
GO:0070400 biolink:NamedThing teichoic acid D-alanylation The formation of a D-alanyl ester of teichoic acid. Alanylation of teichoic acids modulates the properties of the bacterial cell wall and modulates the inflammatory properties of the teichoic acid. got7fsn_ti teichoic acid alanylation biological_process owl:Class
GO:0001565 biolink:NamedThing phorbol ester receptor activity Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0070094 biolink:NamedThing positive regulation of glucagon secretion Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon. got7fsn_ti activation of glucagon secretion|up-regulation of glucagon secretion|upregulation of glucagon secretion|stimulation of glucagon secretion|up regulation of glucagon secretion biological_process owl:Class
GO:0070092 biolink:NamedThing regulation of glucagon secretion Any process that modulates the frequency, rate or extent of the regulated release of glucagon. got7fsn_ti biological_process owl:Class
GO:0035917 biolink:NamedThing negative regulation of calcium channel activity in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism. got7fsn_ti inhibition of calcium channel activity in other organism|downregulation of calcium channel activity in other organism|down-regulation of calcium channel activity in other organism bf 2011-07-01T11:52:55Z biological_process owl:Class
GO:0031203 biolink:NamedThing posttranslational protein targeting to membrane, docking The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex. got7fsn_ti posttranslational protein membrane targeting, docking|Sec-translated protein complex assembly|protein docking during posttranslational protein targeting to membrane biological_process owl:Class
GO:0097503 biolink:NamedThing sialylation The covalent attachment of sialic acid to a substrate molecule. got7fsn_ti pr 2013-09-20T09:53:10Z biological_process owl:Class
GO:0043374 biolink:NamedThing CD8-positive, alpha-beta T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell. got7fsn_ti CD8-positive, alpha-beta T-cell differentiation|CD8-positive, alpha-beta T-lymphocyte differentiation|CD8-positive, alpha-beta T lymphocyte differentiation|CD8-positive, alpha-beta T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0051555 biolink:NamedThing flavonol biosynthetic process The chemical reactions and pathways resulting in the formation of flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities. got7fsn_ti MetaCyc:PWY-3101 biological_process owl:Class
GO:0051553 biolink:NamedThing flavone biosynthetic process The chemical reactions and pathways resulting in the formation of flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). got7fsn_ti 2-phenylchromone biosynthetic process|2-phenyl-4H-1-benzopyran-4-one biosynthetic process|2-phenyl-4H-1-benzopyran-4-one biosynthesis|2-phenylchromone biosynthesis biological_process owl:Class
GO:0015467 biolink:NamedThing G-protein activated inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. got7fsn_ti G-protein-activated inward rectifier potassium channel activity|G protein activated inward rectifier potassium channel activity|G-protein enhanced inward rectifier potassium channel activity|G protein enhanced inward rectifier potassium channel activity|G-protein-enhanced inward rectifier potassium channel activity GO:0015273 Reactome:R-HSA-1013020 molecular_function owl:Class
GO:0005242 biolink:NamedThing inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. got7fsn_ti Kir channel activity Reactome:R-HSA-1296046|Reactome:R-HSA-1296045|Reactome:R-HSA-5678261|Reactome:R-HSA-5678418|Reactome:R-HSA-1369017 molecular_function owl:Class
GO:1990727 biolink:NamedThing tubulin folding cofactor complex A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur. got7fsn_ti pr 2015-04-08T10:29:43Z cellular_component owl:Class
GO:0098542 biolink:NamedThing defense response to other organism Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism. got7fsn_ti defence response to pathogen, incompatible interaction|resistance response to pathogen|defense response, incompatible interaction|defence response incompatible interaction https://github.com/geneontology/go-ontology/issues/18737 dos 2013-11-11T12:59:11Z GO:0009814 biological_process owl:Class
GO:0000700 biolink:NamedThing mismatch base pair DNA N-glycosylase activity Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. got7fsn_ti molecular_function owl:Class
GO:0001183 biolink:NamedThing transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I. got7fsn_ti krc 2011-08-15T03:57:25Z biological_process owl:Class
GO:0006362 biolink:NamedThing transcription elongation from RNA polymerase I promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I. got7fsn_ti RNA elongation from Pol I promoter|RNA polymerase I transcription elongation factor activity biological_process owl:Class
GO:0010587 biolink:NamedThing miRNA catabolic process The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. got7fsn_ti microRNA catabolic process biological_process owl:Class
GO:0052839 biolink:NamedThing inositol diphosphate tetrakisphosphate kinase activity Catalysis of the reaction: Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate. got7fsn_ti ai 2011-11-29T04:14:22Z Reactome:R-HSA-1855230|Reactome:R-HSA-1855193 molecular_function owl:Class
GO:0044618 biolink:NamedThing modulation of relaxation of uterine smooth muscle in other organism The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism. got7fsn_ti regulation of relaxation of uterine smooth muscle in other organism jl 2012-07-04T01:56:04Z biological_process owl:Class
GO:0044617 biolink:NamedThing modulation of relaxation of smooth muscle in other organism The process in which an organism effects a change in the relaxation of smooth muscle in a second organism. got7fsn_ti regulation of relaxation of smooth muscle in other organism jl 2012-07-04T01:55:37Z biological_process owl:Class
GO:0031979 biolink:NamedThing plasma membrane-derived thylakoid lumen The volume enclosed by a plasma membrane-derived thylakoid. got7fsn_ti plasma membrane thylakoid lumen cellular_component owl:Class
GO:1990793 biolink:NamedThing substance P secretion, neurotransmission The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter. got7fsn_ti sl 2015-07-09T19:43:36Z biological_process owl:Class
GO:1990772 biolink:NamedThing substance P secretion The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity. got7fsn_ti sl 2015-06-15T18:17:30Z biological_process owl:Class
GO:1902738 biolink:NamedThing regulation of chondrocyte differentiation involved in endochondral bone morphogenesis Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. got7fsn_ti mr 2014-02-26T15:36:15Z biological_process owl:Class
GO:0018408 biolink:NamedThing peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine). got7fsn_ti RESID:AA0178 biological_process owl:Class
GO:0018078 biolink:NamedThing peptidyl-thyronine iodination The iodination of peptidyl-thyronine, formed from tyrosine. got7fsn_ti RESID:AA0178|RESID:AA0177 biological_process owl:Class
GO:0098633 biolink:NamedThing collagen fibril binding Binding to a collagen fibril. got7fsn_ti molecular_function owl:Class
GO:0070848 biolink:NamedThing response to growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. got7fsn_ti response to growth factor stimulus mah 2009-08-04T04:24:18Z biological_process owl:Class
GO:0072552 biolink:NamedThing monoferuloyl di-(hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the reaction: monoferuloyl di-(hydroxyferuloyl) spermidine + NADPH + O2 = tri-(hydroxyferuloyl) spermidine + NADP+ + H2O. got7fsn_ti mah 2011-01-25T03:15:31Z molecular_function owl:Class
GO:0052814 biolink:NamedThing medium-chain-aldehyde dehydrogenase activity Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons. got7fsn_ti medium-chain-aldehyde:NAD+ oxidoreductase activity|medium-chain aliphatic aldehyde dehydrogenase activity|medium-chain fatty aldehyde dehydrogenase activity 2011-10-25T03:04:41Z EC:1.2.1.- molecular_function owl:Class
GO:0061607 biolink:NamedThing peptide alpha-N-propionyltransferase activity Catalysis of the reaction: propionyl-CoA + peptide = CoA + N-alpha-propionylpeptide. This reaction is the propionylation of the N-terminal amino acid residue of a peptide or protein. got7fsn_ti N-terminal propionyltransferase activity dph 2014-02-11T14:24:35Z molecular_function owl:Class
GO:0071081 biolink:NamedThing alpha3-beta1 integrin-CD63 complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD63. got7fsn_ti ITGA3-ITGB1-CD63 complex mah 2009-11-06T04:43:43Z cellular_component owl:Class
GO:0000751 biolink:NamedThing mitotic cell cycle G1 arrest in response to pheromone The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti cell cycle arrest in response to pheromone GO:0030571 biological_process owl:Class
GO:0045930 biolink:NamedThing negative regulation of mitotic cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle. got7fsn_ti inhibition of progression through mitotic cell cycle|down-regulation of progression through mitotic cell cycle|down regulation of progression through mitotic cell cycle|negative regulation of progression through mitotic cell cycle|negative regulation of mitotic cell cycle progression|downregulation of progression through mitotic cell cycle biological_process owl:Class
GO:0048045 biolink:NamedThing trans-pentaprenyltranstransferase activity Catalysis of the reaction: all-trans-pentaprenyl diphosphate + isopentenyl diphosphate = all-trans-hexaprenyl diphosphate + diphosphate. got7fsn_ti all-trans-pentaprenyl-diphosphate:isopentenyl-diphosphate pentaprenyltranstransferase activity|hexaprenyl diphosphate synthase activity|all-trans-hexaprenyl-diphosphate synthase activity|hexaprenyl pyrophosphate synthetase activity KEGG_REACTION:R05613|RHEA:22632 molecular_function owl:Class
GO:0071127 biolink:NamedThing alpha9-beta1 integrin-osteopontin complex A protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin. got7fsn_ti ITGA9-ITGB1-SPP1 complex mah 2009-11-13T02:24:09Z cellular_component owl:Class
GO:0051062 biolink:NamedThing UDP reductase activity Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin. got7fsn_ti UDP reduction RHEA:28026|MetaCyc:UDPREDUCT-RXN molecular_function owl:Class
GO:0090659 biolink:NamedThing walking behavior The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. got7fsn_ti locomotor gait pattern tb 2015-08-27T16:34:28Z biological_process owl:Class
GO:0008818 biolink:NamedThing cobalamin 5'-phosphate synthase activity Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP. got7fsn_ti RHEA:23560|MetaCyc:COBALAMIN5PSYN-RXN molecular_function owl:Class
GO:0033426 biolink:NamedThing CAC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAC codon. got7fsn_ti histidine tRNA Note that in the standard genetic code, CAC codes for histidine. molecular_function owl:Class
GO:0050881 biolink:NamedThing musculoskeletal movement The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system. got7fsn_ti biological_process owl:Class
GO:0050905 biolink:NamedThing neuromuscular process Any process pertaining to the functions of the nervous and muscular systems of an organism. got7fsn_ti neuromotor process|neuromuscular physiological process biological_process owl:Class
GO:0030130 biolink:NamedThing clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. got7fsn_ti clathrin coat of TGN vesicle cellular_component owl:Class
GO:0075342 biolink:NamedThing disruption by symbiont of host cell PML body The breakdown, by the symbiont, of a PML body within a host cell. A PML body is a nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia). The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti disassembly by symbiont of host cell PML NB|degradation by symbiont of host cell PML body|disassembly by symbiont of host cell PML nuclear body|catabolism by symbiont of host cell PML body|disassembly by symbiont of host cell PML body|disassembly by symbiont of host cell PML body during symbiotic interaction biological_process owl:Class
GO:0018759 biolink:NamedThing methenyltetrahydromethanopterin cyclohydrolase activity Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+). got7fsn_ti 5,10-methenyltetrahydromethanopterin cyclohydrolase activity|5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)|N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity|methenyl-H4MPT cyclohydrolase activity|methenyl-H(4)MPT cyclohydrolase activity EC:3.5.4.27|KEGG_REACTION:R03464|UM-BBD_reactionID:r0347|MetaCyc:3.5.4.27-RXN|RHEA:19053 molecular_function owl:Class
GO:1990414 biolink:NamedThing replication-born double-strand break repair via sister chromatid exchange The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks. got7fsn_ti replication-born DSB repair by SCE rb 2014-07-10T21:20:34Z biological_process owl:Class
GO:0000724 biolink:NamedThing double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. got7fsn_ti homologous recombinational repair|homology-directed repair|HDR|HRR|Rhp51-dependent recombinational repair|Rad51-dependent recombinational repair GO:0016924 biological_process owl:Class
GO:0048190 biolink:NamedThing wing disc dorsal/ventral pattern formation The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing. got7fsn_ti wing disc dorsal-ventral pattern formation|wing disc dorsoventral pattern formation biological_process owl:Class
GO:0035222 biolink:NamedThing wing disc pattern formation The process giving rise to the pattern of cell differentiation in the wing imaginal disc. got7fsn_ti biological_process owl:Class
GO:0018697 biolink:NamedThing carbonyl sulfide nitrogenase activity Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide. got7fsn_ti carbonyl sulphide nitrogenase activity EC:1.18.6.1|UM-BBD_reactionID:r0600 molecular_function owl:Class
GO:0043076 biolink:NamedThing megasporocyte nucleus The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents. got7fsn_ti megaspore mother cell nucleus cellular_component owl:Class
GO:0005634 biolink:NamedThing nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. got7fsn_ti horsetail nucleus|cell nucleus Wikipedia:Cell_nucleus|NIF_Subcellular:sao1702920020 cellular_component owl:Class
GO:1990689 biolink:NamedThing endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport. got7fsn_ti ERGIC-derived vesicle fusion with cis-Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with cis-Golgi cisterna membrane|ERGIC-derived vesicle fusion with Golgi cis cisterna membrane|ER-Golgi intermediate compartment derived vesicle fusion with cis-Golgi cisterna membrane|ER-Golgi intermediate compartment derived vesicle fusion with Golgi cis cisterna membrane bhm 2015-03-12T09:41:48Z biological_process owl:Class
GO:1990670 biolink:NamedThing vesicle fusion with Golgi cis cisterna membrane The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles. got7fsn_ti bhm 2015-03-02T11:25:19Z biological_process owl:Class
GO:0023028 biolink:NamedThing MHC class I protein binding, via lateral surface Binding to a major histocompatibility complex class I molecules via the lateral surface. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0042288 biolink:NamedThing MHC class I protein binding Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. got7fsn_ti major histocompatibility complex class I ligand|T cell receptor activity|major histocompatibility complex class I binding|gamma-delta T cell receptor activity|alpha-beta T cell receptor activity Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. molecular_function owl:Class
GO:0071202 biolink:NamedThing Kv4.3-DPP10 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.3. got7fsn_ti Kv4.3-DPPY channel complex mah 2009-11-23T05:21:37Z CORUM:598 cellular_component owl:Class
GO:0047938 biolink:NamedThing glucose-6-phosphate 1-epimerase activity Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate. got7fsn_ti D-glucose-6-phosphate 1-epimerase activity|glucose-6 phosphate 1-epimerase activity RHEA:16249|MetaCyc:GLUCOSE-6-PHOSPHATE-1-EPIMERASE-RXN|EC:5.1.3.15 molecular_function owl:Class
GO:0052878 biolink:NamedThing linoleate 8R-lipoxygenase activity Catalysis of the reaction: O(2) + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate. got7fsn_ti 5,8-linoleate diol synthase (bifunctional enzyme) activity|7,8-LDS (bifunctional enzyme) activity|7,8-linoleate diol synthase (bifunctional enzyme) activity|5,8-LDS (bifunctional enzyme) activity|linoleate diol synthase activity MetaCyc:1.13.11.44-RXN|KEGG_REACTION:R07061|EC:1.13.11.60|RHEA:25395 molecular_function owl:Class
GO:0071706 biolink:NamedThing tumor necrosis factor superfamily cytokine production The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti TNFSF cytokine production|TNF superfamily production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. mah 2010-03-09T02:40:35Z biological_process owl:Class
GO:0034941 biolink:NamedThing pyrrole-2-carboxylate decarboxylase activity Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2. got7fsn_ti EC:4.1.1.93|UM-BBD_reactionID:r0970 molecular_function owl:Class
GO:0047346 biolink:NamedThing aldose-1-phosphate adenylyltransferase activity Catalysis of the reaction: aldose 1-phosphate + ADP = phosphate + ADP-aldose. got7fsn_ti adenosine diphosphate glucose:orthophosphate adenylyltransferase activity|ADP sugar phosphorylase activity|ADPaldose phosphorylase activity|ADP-sugar phosphorylase activity|ADP-aldose phosphorylase activity|adenosine diphosphosugar phosphorylase activity|ADP:alpha-D-aldose-1-phosphate adenylyltransferase activity|ADP:aldose-1-phosphate adenylyltransferase activity|sugar-1-phosphate adenylyltransferase activity MetaCyc:2.7.7.36-RXN|EC:2.7.7.36 molecular_function owl:Class
GO:1990199 biolink:NamedThing MsbA transporter complex An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD). got7fsn_ti MsbA dimer|MsbA complex bhm 2013-10-01T07:49:41Z cellular_component owl:Class
GO:0043190 biolink:NamedThing ATP-binding cassette (ABC) transporter complex A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. got7fsn_ti ABC-type efflux porter complex|ABC-type efflux permease complex|mating pheromone exporter|ABC-type uptake permease complex GO:0043192|GO:0043191 cellular_component owl:Class
GO:0021501 biolink:NamedThing prechordal plate formation The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells. got7fsn_ti biological_process owl:Class
GO:0047106 biolink:NamedThing 4-hydroxyphenylacetaldehyde dehydrogenase activity Catalysis of the reaction: NAD+ + (4-hydroxyphenyl)acetaldehyde + H2O = NADH + 4-hydroxyphenylacetate. got7fsn_ti 4-HPAL dehydrogenase activity|4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase activity MetaCyc:1.2.1.53-RXN|EC:1.2.1.53|RHEA:17273 molecular_function owl:Class
GO:0006237 biolink:NamedThing deoxycytidine salvage Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0061818 biolink:NamedThing tRNA folding The process of assisting in the folding of tRNAs into the correct tertiary structure. got7fsn_ti dph 2016-12-13T15:54:40Z biological_process owl:Class
GO:0034337 biolink:NamedThing RNA folding The process of assisting in the covalent and noncovalent assembly of single or multimeric RNAs into the correct tertiary structure. got7fsn_ti RNA chaperone biological_process owl:Class
GO:0001981 biolink:NamedThing baroreceptor detection of arterial stretch The series of events by which the change in diameter of an artery is detected and converted to a molecular signal. got7fsn_ti biological_process owl:Class
GO:0070259 biolink:NamedThing tyrosyl-DNA phosphodiesterase activity Catalysis of the hydrolysis of phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between a DNA topoisomerase and DNA. got7fsn_ti See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. molecular_function owl:Class
GO:0098881 biolink:NamedThing exocytic insertion of neurotransmitter receptor to plasma membrane The exocytic fusion of neurotransmitter receptor-containing vesicles with plasma membrane, resulting in the integration of neurotransmitter receptors into the plasma membrane. This process includes tethering and docking steps that prepare vesicles for fusion. got7fsn_ti neurotransmitter receptor insertion biological_process owl:Class
GO:0090522 biolink:NamedThing vesicle tethering involved in exocytosis The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. got7fsn_ti vesicle tethering to plasma membrane tb 2013-01-08T15:07:50Z biological_process owl:Class
GO:0008630 biolink:NamedThing intrinsic apoptotic signaling pathway in response to DNA damage A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. got7fsn_ti DNA damage response, signal transduction resulting in induction of apoptosis biological_process owl:Class
GO:0001127 biolink:NamedThing transcription open complex formation at bacterial-type RNA polymerase promoter Any process involved in the melting of the DNA hybrid of the core promoter region within a bacterial-type RNA polymerase promoter to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. got7fsn_ti transcriptional open complex formation at bacterial-type RNA polymerase promoter krc 2010-12-06T04:04:16Z biological_process owl:Class
GO:0001112 biolink:NamedThing DNA-templated transcription open complex formation Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. got7fsn_ti promoter melting|DNA-dependent transcriptional open complex formation|DNA-templated transcriptional open complex formation krc 2010-12-02T02:15:04Z biological_process owl:Class
GO:0050032 biolink:NamedThing L-rhamnonate dehydratase activity Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O. got7fsn_ti L-rhamnonate hydro-lyase activity|L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming) KEGG_REACTION:R03774|EC:4.2.1.90|MetaCyc:L-RHAMNONATE-DEHYDRATASE-RXN|RHEA:23080 molecular_function owl:Class
GO:0018364 biolink:NamedThing peptidyl-glutamine methylation The addition of a methyl group to a glutamine residue in a protein. got7fsn_ti biological_process owl:Class
GO:0043041 biolink:NamedThing amino acid activation for nonribosomal peptide biosynthetic process Activation of an amino acid for incorporation into a peptide by a nonribosomal process. got7fsn_ti nonribosomal amino acid activation biological_process owl:Class
GO:0043038 biolink:NamedThing amino acid activation The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule. got7fsn_ti biological_process owl:Class
GO:0042741 biolink:NamedThing endogenous antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism. got7fsn_ti endogenous antibiotic catabolism|endogenous antibiotic degradation|endogenous antibiotic breakdown biological_process owl:Class
GO:0004902 biolink:NamedThing granulocyte colony-stimulating factor receptor activity Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti granulocyte colony stimulating factor receptor activity|G-CSF receptor activity|CSF3R GO:0030524 molecular_function owl:Class
GO:0019332 biolink:NamedThing aerobic respiration, using nitrite as electron donor The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species. got7fsn_ti nitrite oxidation MetaCyc:P282-PWY biological_process owl:Class
GO:0019696 biolink:NamedThing toluene oxidation via toluene-cis-1,2-dihydrodiol The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol. got7fsn_ti MetaCyc:TOLUENE-DEG-DIOL-PWY biological_process owl:Class
GO:0140027 biolink:NamedThing establishment of contractile vacuole localization The directed movement of the contractile vacuole to a specific location. got7fsn_ti pg 2017-05-02T10:23:26Z biological_process owl:Class
GO:0051656 biolink:NamedThing establishment of organelle localization The directed movement of an organelle to a specific location. got7fsn_ti establishment of organelle localisation biological_process owl:Class
GO:0140447 biolink:NamedThing cytokine precursor processing The cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine. got7fsn_ti interleukin maturation|interleukin processing https://github.com/geneontology/go-ontology/issues/19216 pg 2020-04-03T12:49:29Z biological_process owl:Class
GO:0140448 biolink:NamedThing signaling receptor ligand precursor processing The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand. got7fsn_ti ligand maturation|signal maturation https://github.com/geneontology/go-ontology/issues/19216 pg 2020-04-03T13:30:04Z GO:0035638 biological_process owl:Class
GO:0010322 biolink:NamedThing regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent). got7fsn_ti regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway biological_process owl:Class
GO:0032504 biolink:NamedThing multicellular organism reproduction The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. got7fsn_ti biological_process owl:Class
GO:0000003 biolink:NamedThing reproduction The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms. got7fsn_ti reproductive physiological process GO:0050876|GO:0019952 Wikipedia:Reproduction biological_process owl:Class
GO:0048001 biolink:NamedThing erythrose-4-phosphate dehydrogenase activity Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + NAD(+) = 4-phospho-D-erythronate + 2 H(+) + NADH. got7fsn_ti D-erythrose 4-phosphate:NAD+ oxidoreductase activity|E4PDH|GapB|Epd dehydrogenase activity|E4P dehydrogenase activity|erythrose 4-phosphate dehydrogenase activity GO:0033724 KEGG_REACTION:R01825|RHEA:12056|EC:1.2.1.72|MetaCyc:ERYTH4PDEHYDROG-RXN molecular_function owl:Class
GO:0051661 biolink:NamedThing maintenance of centrosome location Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of centrosome localization biological_process owl:Class
GO:0061054 biolink:NamedThing dermatome development The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. got7fsn_ti dph 2010-03-02T12:07:37Z biological_process owl:Class
GO:0000808 biolink:NamedThing origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. got7fsn_ti origin of replication recognition complex|ORC Wikipedia:Origin_recognition_complex cellular_component owl:Class
GO:0043919 biolink:NamedThing agmatine aminopropyltransferase activity Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine. got7fsn_ti agmatine aminopropyl transferase activity EC:2.5.1.104 molecular_function owl:Class
GO:0052723 biolink:NamedThing inositol hexakisphosphate 1-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 1-diphospho-1D-myo-inositol (2,3,4,5,6)pentakisphosphate. got7fsn_ti ai 2011-08-16T11:47:36Z MetaCyc:RXN-10972|RHEA:37459|EC:2.7.4.21|KEGG_REACTION:R05799 molecular_function owl:Class
GO:0001207 biolink:NamedThing histone displacement The removal of histones, including histone dimers, from nucleosomes within chromatin. got7fsn_ti krc 2012-03-27T10:56:56Z biological_process owl:Class
GO:0061510 biolink:NamedThing asymmetric protein localization to new mitotic spindle pole body Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically. got7fsn_ti dph 2013-02-21T13:49:54Z biological_process owl:Class
GO:0061492 biolink:NamedThing asymmetric protein localization to old or new spindle pole body Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically. got7fsn_ti dph 2012-12-06T15:23:15Z biological_process owl:Class
GO:0047790 biolink:NamedThing creatinine deaminase activity Catalysis of the reaction: creatinine + H2O = N-methylhydantoin + NH3. got7fsn_ti creatinine desiminase activity|creatinine hydrolase|creatinine iminohydrolase activity MetaCyc:CREATININE-DEAMINASE-RXN|EC:3.5.4.21|RHEA:12681 molecular_function owl:Class
GO:0120295 biolink:NamedThing histone serotonyltransferase activity Catalysis of the reaction: L-glutaminyl-[histone] + serotonin = 5-serotonyl-L-glutamyl-[histone] + NH4(+). got7fsn_ti https://github.com/geneontology/go-ontology/issues/20685 krc 2021-01-19T02:13:19Z molecular_function owl:Class
GO:0120294 biolink:NamedThing peptide serotonyltransferase activity Catalysis of the reaction: L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+). got7fsn_ti https://github.com/geneontology/go-ontology/issues/20685 krc 2021-01-19T02:07:56Z RHEA:66552 molecular_function owl:Class
GO:0003294 biolink:NamedThing atrial ventricular junction remodeling The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle. got7fsn_ti atrioventricular junction remodeling|atrio-ventricular junction remodeling dph 2009-10-22T08:35:36Z biological_process owl:Class
GO:0019409 biolink:NamedThing aerobic respiration, using ammonia as electron donor The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite. got7fsn_ti aerobic ammonia oxidation to nitrite via hydrazine MetaCyc:AMMOXID-PWY biological_process owl:Class
GO:0046564 biolink:NamedThing oxalate decarboxylase activity Catalysis of the reaction: H(+) + oxalate = CO(2) + formate. got7fsn_ti oxalate carboxy-lyase (formate-forming)|oxalate carboxy-lyase activity MetaCyc:OXALATE-DECARBOXYLASE-RXN|RHEA:16509|KEGG_REACTION:R00522|EC:4.1.1.2 molecular_function owl:Class
GO:0033981 biolink:NamedThing D-dopachrome decarboxylase activity Catalysis of the reaction: D-dopachrome + H(+) = 5,6-dihydroxyindole + CO(2). got7fsn_ti phenylpyruvate tautomerase II activity|dopachrome decarboxylase activity|dopachrome conversion activity|D-dopachrome carboxy-lyase (5,6-dihydroxyindole-forming) activity|D-dopachrome carboxy-lyase activity|D-dopachrome tautomerase activity|D-tautomerase activity GO:0030928 KEGG_REACTION:R07313|MetaCyc:4.1.1.84-RXN|EC:4.1.1.84|RHEA:18441 molecular_function owl:Class
GO:0050826 biolink:NamedThing response to freezing Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. got7fsn_ti antifreeze activity|ice nucleation inhibitor activity biological_process owl:Class
GO:0030504 biolink:NamedThing inorganic diphosphate transmembrane transporter activity Enables the transfer of inorganic diphosphate across a membrane. got7fsn_ti inorganic pyrophosphate transporter activity Reactome:R-HSA-5226964 molecular_function owl:Class
GO:0015103 biolink:NamedThing inorganic anion transmembrane transporter activity Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. got7fsn_ti molecular_function owl:Class
GO:0030875 biolink:NamedThing rDNA protrusion Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining. got7fsn_ti ribosomal DNA protrusion Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern. cellular_component owl:Class
GO:0043182 biolink:NamedThing vacuolar sequestering of sodium ion The process of transporting sodium ions into, and confining within, a vacuole. got7fsn_ti sodium ion (Na+) retention in vacuole|sequestration of sodium ion (Na+) in vacuole|vacuolar sequestering of sodium ion (Na+)|vacuolar sodium ion (Na+) retention|vacuolar sodium ion (Na+) storage|sodium ion (Na+) storage in vacuole|vacuolar sequestration of sodium ion (Na+)|sequestering of sodium ion (Na+) in vacuole biological_process owl:Class
GO:0043181 biolink:NamedThing vacuolar sequestering The process of transporting a substance into, and confining within, a vacuole. got7fsn_ti vacuolar sequestration|storage in vacuole|retention in vacuole|sequestering in vacuole|vacuolar retention|sequestration in vacuole|vacuolar storage biological_process owl:Class
GO:0050065 biolink:NamedThing lysine-pyruvate 6-transaminase activity Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine. got7fsn_ti Lys-AT|lysine-pyruvate aminotransferase activity|lysine--pyruvate 6-aminotransferase activity|L-lysine:pyruvate aminotransferase activity MetaCyc:LYSINE--PYRUVATE-6-AMINOTRANSFERASE-RXN|KEGG_REACTION:R00453|MetaCyc:PWY-5324|EC:2.6.1.71|RHEA:19393 molecular_function owl:Class
GO:0051594 biolink:NamedThing detection of glucose The series of events in which a glucose stimulus is received by a cell and converted into a molecular signal. got7fsn_ti glucose perception|glucose sensing|glucose detection biological_process owl:Class
GO:0009732 biolink:NamedThing detection of hexose stimulus The series of events in which a stimulus from a hexose is received and converted into a molecular signal. got7fsn_ti perception of hexose stimulus biological_process owl:Class
GO:0140651 biolink:NamedThing futile creatine cycle The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21517 pg 2021-05-26T06:40:18Z biological_process owl:Class
GO:0120316 biolink:NamedThing sperm flagellum assembly The assembly and organization of the sperm flagellum, the microtubule-based axoneme and associated structures that are part of a sperm flagellum (or cilium). got7fsn_ti krc 2021-04-29T01:27:27Z biological_process owl:Class
GO:0072360 biolink:NamedThing vascular cord development The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis. got7fsn_ti mah 2010-11-16T11:46:55Z biological_process owl:Class
GO:0042715 biolink:NamedThing dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans. got7fsn_ti dosage compensation complex assembly during dosage compensation by hypoactivation of X chromosome biological_process owl:Class
GO:0071110 biolink:NamedThing histone biotinylation The modification of a histone by the addition of a biotinyl group. got7fsn_ti mah 2009-11-13T01:22:59Z biological_process owl:Class
GO:1990888 biolink:NamedThing 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+. got7fsn_ti sl 2015-10-28T22:31:13Z molecular_function owl:Class
GO:0007406 biolink:NamedThing negative regulation of neuroblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. got7fsn_ti inhibition of neuroblast proliferation|downregulation of neuroblast proliferation|down-regulation of neuroblast proliferation|down regulation of neuroblast proliferation|suppression of neuroblast proliferation biological_process owl:Class
GO:0002342 biolink:NamedThing central B cell deletion The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection. got7fsn_ti central B-lymphocyte deletion|central B lymphocyte deletion|central B-cell deletion biological_process owl:Class
GO:0002516 biolink:NamedThing B cell deletion The apoptotic death of B cells which is part of B cell tolerance induction. got7fsn_ti B-lymphocyte deletion|B-cell deletion|B lymphocyte deletion biological_process owl:Class
GO:0036122 biolink:NamedThing BMP binding Binding to a member of the bone morphogenetic protein (BMP) family. got7fsn_ti bone morphogenetic protein binding bf 2012-02-20T02:59:34Z molecular_function owl:Class
GO:0043732 biolink:NamedThing 6-hydroxynicotinate dehydrogenase activity Catalysis of the reaction: 6-hydroxynicotinate + H(2)O + O(2) = 2,6-dihydroxynicotinate + H(2)O(2). got7fsn_ti 6-hydroxynicotinate:O2 oxidoreductase activity|6-hydroxynicotinate hydroxylase activity|6-hydroxynicotinic acid hydroxylase activity|6-hydroxynicotinic acid dehydrogenase activity MetaCyc:RXN-7585|KEGG_REACTION:R07221|EC:1.17.3.3|RHEA:22808 molecular_function owl:Class
GO:0016727 biolink:NamedThing oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. got7fsn_ti EC:1.17.3.- molecular_function owl:Class
GO:0018275 biolink:NamedThing N-terminal peptidyl-cysteine acetylation The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine. got7fsn_ti peptidyl-cysteine N-acetylation GO:0017191 RESID:AA0043 biological_process owl:Class
GO:1903531 biolink:NamedThing negative regulation of secretion by cell Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell. got7fsn_ti downregulation of secretion by cell|inhibition of secretion by cell|down-regulation of cellular secretion|negative regulation of cellular secretion|inhibition of cellular secretion|down-regulation of secretion by cell|down regulation of cellular secretion|down regulation of secretion by cell|downregulation of cellular secretion pm 2014-10-08T13:25:08Z biological_process owl:Class
GO:1990273 biolink:NamedThing snRNA 5'-end processing Any process involved in forming the mature 5' end of an snRNA molecule. got7fsn_ti al 2014-01-15T15:32:06Z biological_process owl:Class
GO:0016180 biolink:NamedThing snRNA processing Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. got7fsn_ti biological_process owl:Class
GO:0034044 biolink:NamedThing exomer complex A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues. got7fsn_ti cellular_component owl:Class
GO:0018171 biolink:NamedThing peptidyl-cysteine oxidation The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid. got7fsn_ti RESID:AA0205|RESID:AA0262 biological_process owl:Class
GO:1904252 biolink:NamedThing negative regulation of bile acid metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of bile acid metabolic process. got7fsn_ti down regulation of bile acid metabolic process|negative regulation of bile acid metabolism|downregulation of bile acid metabolism|downregulation of bile acid metabolic process|inhibition of bile acid metabolic process|inhibition of bile acid metabolism|down-regulation of bile acid metabolic process|down-regulation of bile acid metabolism|down regulation of bile acid metabolism bf 2015-05-20T11:04:35Z biological_process owl:Class
GO:0031324 biolink:NamedThing negative regulation of cellular metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. got7fsn_ti down regulation of cellular metabolic process|inhibition of cellular metabolic process|down-regulation of cellular metabolic process|negative regulation of cellular metabolism|downregulation of cellular metabolic process biological_process owl:Class
GO:1903708 biolink:NamedThing positive regulation of hemopoiesis Any process that activates or increases the frequency, rate or extent of hemopoiesis. got7fsn_ti positive regulation of blood cell formation|activation of blood cell biosynthesis|upregulation of blood cell biosynthesis|upregulation of haemopoiesis|up regulation of hematopoiesis|up-regulation of hemopoiesis|positive regulation of haemopoiesis|positive regulation of blood cell biosynthesis|upregulation of hematopoiesis|upregulation of blood cell formation|up-regulation of blood cell biosynthesis|up regulation of haemopoiesis|upregulation of hemopoiesis|up regulation of blood cell biosynthesis|activation of hemopoiesis|up-regulation of haemopoiesis|activation of hematopoiesis|positive regulation of hematopoiesis|up regulation of hemopoiesis|up-regulation of hematopoiesis|up regulation of blood cell formation|activation of blood cell formation|activation of haemopoiesis|up-regulation of blood cell formation An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. pad 2014-12-04T15:34:30Z biological_process owl:Class
GO:0009641 biolink:NamedThing shade avoidance Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome. got7fsn_ti Wikipedia:Shade_avoidance biological_process owl:Class
GO:0055020 biolink:NamedThing positive regulation of cardiac muscle fiber development Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development. got7fsn_ti up regulation of cardiac muscle fiber development|activation of cardiac muscle fiber development|upregulation of cardiac muscle fiber development|positive regulation of cardiac muscle fibre development|positive regulation of heart muscle fiber development|stimulation of cardiac muscle fiber development|up-regulation of cardiac muscle fiber development biological_process owl:Class
GO:0075243 biolink:NamedThing oospore formation The process in which male and female gametangia develop and fuse to form an oospore, a thick-walled resting spore of Oomycetes and certain algae and fungi. got7fsn_ti biological_process owl:Class
GO:0043935 biolink:NamedThing sexual sporulation resulting in formation of a cellular spore The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. got7fsn_ti biological_process owl:Class
GO:0032188 biolink:NamedThing establishment of actomyosin contractile ring localization The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis. got7fsn_ti establishment of contractile ring localization involved in cytokinesis during cell cycle|cytokinesis site selection by contractile ring positioning|contractile ring positioning|actomyosin ring positioning|establishment of contractile ring localization involved in cell cycle cytokinesis|establishment of contractile ring localisation involved in cell cycle cytokinesis biological_process owl:Class
GO:0032187 biolink:NamedThing actomyosin contractile ring localization The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle. got7fsn_ti contractile ring localisation involved in cell cycle cytokinesis|contractile ring localization involved in cell cycle cytokinesis biological_process owl:Class
GO:0032482 biolink:NamedThing Rab protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. got7fsn_ti biological_process owl:Class
GO:0007265 biolink:NamedThing Ras protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. got7fsn_ti Ras mediated signal transduction biological_process owl:Class
GO:0102605 biolink:NamedThing cyclooctat-9-en-5,7-diol C18-monooxygenase activity Catalysis of the reaction: cyclooctat-9-en-5,7-diol + O2 + NADPH + H+ <=> cyclooctatin + H2O + NADP. got7fsn_ti MetaCyc:RXN-15430|RHEA:56824 molecular_function owl:Class
GO:0103030 biolink:NamedThing ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity Catalysis of the reaction: H+ + methylglyoxal + NADH = hydroxyacetone + NAD. got7fsn_ti RHEA:35615|MetaCyc:RXN0-5213 molecular_function owl:Class
GO:0008093 biolink:NamedThing cytoskeletal anchor activity The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way. got7fsn_ti cytoskeletal adaptor activity https://github.com/geneontology/go-ontology/issues/19119|https://github.com/geneontology/go-ontology/issues/17668 molecular_function owl:Class
GO:0072295 biolink:NamedThing specification of metanephric distal tubule identity The process in which the distal tubule of the metanephric nephron acquires its identity. got7fsn_ti mah 2010-04-09T04:01:42Z biological_process owl:Class
GO:0072084 biolink:NamedThing specification of distal tubule identity The process in which the distal tubule of the kidney nephron acquires its identity. got7fsn_ti mah 2010-02-01T02:47:53Z biological_process owl:Class
GO:0042265 biolink:NamedThing peptidyl-asparagine hydroxylation The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine. got7fsn_ti peptidyl-aspartic acid/asparagine hydroxylation biological_process owl:Class
GO:0071166 biolink:NamedThing ribonucleoprotein complex localization Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell. got7fsn_ti RNP localization|ribonucleoprotein complex localisation|cellular ribonucleoprotein complex localization|establishment and maintenance of ribonucleoprotein complex localization mah 2009-11-19T04:46:05Z biological_process owl:Class
GO:0004111 biolink:NamedThing creatine kinase activity Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). got7fsn_ti MB-CK|MiMi-CK|MM-CK|BB-CK|CK-MB|creatine phosphokinase activity|CK-MM|adenosine triphosphate-creatine transphosphorylase activity|ATP:creatine N-phosphotransferase activity|ATP:creatine phosphotransferase activity|CK-BB|creatine phosphotransferase activity|CKMiMi|Mi-CK|phosphocreatine kinase activity|CK Reactome:R-HSA-200326|EC:2.7.3.2|Reactome:R-HSA-200318|RHEA:17157|MetaCyc:CREATINE-KINASE-RXN|KEGG_REACTION:R01881 molecular_function owl:Class
GO:0047530 biolink:NamedThing 2,4-diaminopentanoate dehydrogenase activity Catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+. got7fsn_ti 2,4-diaminopentanoate:NAD(P)+ oxidoreductase (deaminating)|2,4-diaminopentanoic acid C4 dehydrogenase activity EC:1.4.1.12|MetaCyc:24-DIAMINOPENTANOATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0060585 biolink:NamedThing positive regulation of prostaglandin-endoperoxide synthase activity Any process that increases the rate, frequency or extent of prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. got7fsn_ti positive regulation of (PG)H synthase activity|positive regulation of fatty acid cyclooxygenase activity|positive regulation of PG synthetase activity|positive regulation of prostaglandin synthetase activity dph 2009-05-08T02:12:34Z biological_process owl:Class
GO:0051353 biolink:NamedThing positive regulation of oxidoreductase activity Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. got7fsn_ti stimulation of oxidoreductase activity|ribonucleotide reductase activating enzyme activity|activation of oxidoreductase activity|up-regulation of oxidoreductase activity|up regulation of oxidoreductase activity|upregulation of oxidoreductase activity|oxidoreductase activator GO:0009391 biological_process owl:Class
GO:0044159 biolink:NamedThing host thylakoid A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. got7fsn_ti jl 2009-08-11T04:15:34Z cellular_component owl:Class
GO:1990825 biolink:NamedThing sequence-specific mRNA binding Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif. got7fsn_ti sl 2015-08-19T17:42:50Z molecular_function owl:Class
GO:0047841 biolink:NamedThing dehydrogluconokinase activity Catalysis of the reaction: 2-dehydro-D-gluconate + ATP = 6-phospho-2-dehydro-D-gluconate + ADP + 2 H(+). got7fsn_ti 2-ketogluconate kinase activity|dehydogluconokinase activity|ketogluconokinase activity|ATP:2-dehydro-D-gluconate 6-phosphotransferase activity|2-ketogluconokinase activity|ketogluconokinase (phosphorylating) RHEA:10788|KEGG_REACTION:R02658|EC:2.7.1.13|MetaCyc:DEHYDOGLUCONOKINASE-RXN molecular_function owl:Class
GO:0004445 biolink:NamedThing inositol-polyphosphate 5-phosphatase activity Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. got7fsn_ti Ins(1,4,5)P(3) 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity|D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity|inositol 1,4,5-trisphosphate phosphatase activity|inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity|5PTase activity|Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity|InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity|type II inositol polyphosphate 5-phosphatase activity|InsP3/Ins(1,3,4,5)P4 5-phosphatase activity|inositol trisphosphate phosphomonoesterase activity|type II inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol phosphate 5-phosphomonoesterase activity|inositol polyphosphate-5-phosphatase activity|L-myo-inositol 1,4,5-trisphosphate-monoesterase activity|type I inositol-polyphosphate phosphatase activity|1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity|D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity|Ins(1,4,5)P3 5-phosphatase activity|myo-inositol-1,4,5-trisphosphate 5-phosphatase activity|inosine triphosphatase activity|inositol triphosphate 5-phosphomonoesterase activity Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'. EC:3.1.3.56 molecular_function owl:Class
GO:0006338 biolink:NamedThing chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. got7fsn_ti ATP-dependent chromatin remodelling|ATP-dependent chromatin remodeling|chromatin modelling|chromatin modeling|chromatin remodelling https://github.com/geneontology/go-ontology/issues/21732 GO:0043044 biological_process owl:Class
GO:0006561 biolink:NamedThing proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. got7fsn_ti proline formation|proline biosynthesis|proline anabolism|proline synthesis MetaCyc:PWY-3341|MetaCyc:PROSYN-PWY biological_process owl:Class
GO:0000325 biolink:NamedThing plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana. got7fsn_ti vacuole, cell cycle-independent morphology cellular_component owl:Class
GO:0033651 biolink:NamedThing host cell plastid Any member of a family of organelles as found in the cytoplasm of host cells, which are membrane-bounded and contain DNA. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cellular_component owl:Class
GO:0070820 biolink:NamedThing tertiary granule A secretory granule that contains cathepsin and gelatinase and is readily exocytosed upon cell activation; found primarily in mature neutrophil cells. got7fsn_ti gelatinase granule mah 2009-07-20T03:57:00Z cellular_component owl:Class
GO:0035578 biolink:NamedThing azurophil granule lumen The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. got7fsn_ti primary granule lumen bf 2010-10-05T01:30:33Z cellular_component owl:Class
GO:0034774 biolink:NamedThing secretory granule lumen The volume enclosed by the membrane of a secretory granule. got7fsn_ti cellular_component owl:Class
GO:0140507 biolink:NamedThing granzyme-mediated programmed cell death signaling pathway A series of molecular signals induced by granzymes which triggers the cell death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of cell death is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce cell death in target cells. got7fsn_ti granzyme-mediated cell death signaling pathway https://github.com/geneontology/go-ontology/issues/19901|http://wiki.geneontology.org/index.php/Apoptosis_Curation_Manual#Other_children_of_apoptotic_signaling_pathway pg 2020-08-27T13:51:40Z biological_process owl:Class
GO:0034691 biolink:NamedThing integrin alphaE-beta7 complex An integrin complex that comprises one alphaE subunit and one beta7 subunit. got7fsn_ti Itgae-Itgb7 complex cellular_component owl:Class
GO:0045806 biolink:NamedThing negative regulation of endocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis. got7fsn_ti downregulation of endocytosis|inhibition of endocytosis|down regulation of endocytosis|down-regulation of endocytosis biological_process owl:Class
GO:0055059 biolink:NamedThing asymmetric neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials. got7fsn_ti biological_process owl:Class
GO:0045499 biolink:NamedThing chemorepellent activity Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. got7fsn_ti chemorepellant activity molecular_function owl:Class
GO:0019922 biolink:NamedThing protein-chromophore linkage via peptidyl-cysteine The covalent linking of a chromophore to a protein via peptidyl-cysteines. got7fsn_ti biological_process owl:Class
GO:0034294 biolink:NamedThing sexual spore wall assembly The aggregation, arrangement and bonding together of a set of components to form a sexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis. got7fsn_ti sexual spore wall formation biological_process owl:Class
GO:0042244 biolink:NamedThing spore wall assembly The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore. got7fsn_ti spore coat biosynthetic process|spore wall formation|spore coat biosynthesis biological_process owl:Class
GO:0102306 biolink:NamedThing benzil reductase [(S)-benzoin-forming] activity Catalysis of the reaction: (S)-benzoin + NADP(3-) <=> benzil + NADPH(4-) + H+. got7fsn_ti EC:1.1.1.320|MetaCyc:RXN-12898|RHEA:25968 molecular_function owl:Class
GO:0048207 biolink:NamedThing vesicle targeting, rough ER to cis-Golgi The process in which vesicles are directed to specific destination membranes during transport from the rough endoplasmic reticulum to the cis-Golgi. got7fsn_ti vesicle targeting, rough endoplasmic reticulum to cis-Golgi|rough ER to cis-Golgi targeting|rough endoplasmic reticulum to cis-Golgi targeting biological_process owl:Class
GO:0048199 biolink:NamedThing vesicle targeting, to, from or within Golgi The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation. got7fsn_ti vesicle targeting, to, from or within dictyosome|Golgi vesicle targeting|dictyosome vesicle targeting biological_process owl:Class
GO:0032347 biolink:NamedThing regulation of aldosterone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. got7fsn_ti biological_process owl:Class
GO:0033973 biolink:NamedThing dCTP deaminase (dUMP-forming) activity Catalysis of the reaction: dCTP + 2 H(2)O = diphosphate + dUMP + H(+) + NH(4)(+). got7fsn_ti dCTP aminohydrolase (dUMP-forming) activity EC:3.5.4.30|RHEA:19205|MetaCyc:3.5.4.30-RXN|KEGG_REACTION:R07307 molecular_function owl:Class
GO:0033675 biolink:NamedThing pericanalicular vesicle A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes. got7fsn_ti cellular_component owl:Class
GO:0071165 biolink:NamedThing GINS complex assembly The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks. got7fsn_ti mah 2009-11-19T03:37:20Z biological_process owl:Class
GO:0071428 biolink:NamedThing rRNA-containing ribonucleoprotein complex export from nucleus The directed movement of a ribonucleoprotein complex that contains ribosomal RNA from the nucleus to the cytoplasm. got7fsn_ti rRNA-containing ribonucleoprotein complex export from cell nucleus|rRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm|rRNA-containing RNP export from nucleus|rRNA-containing ribonucleoprotein complex nucleus export mah 2009-12-16T10:15:07Z biological_process owl:Class
GO:0019902 biolink:NamedThing phosphatase binding Binding to a phosphatase. got7fsn_ti molecular_function owl:Class
GO:0010174 biolink:NamedThing nucleoside transmembrane transporter activity, against a concentration gradient Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient. got7fsn_ti concentrative nucleoside transporter activity molecular_function owl:Class
GO:0015089 biolink:NamedThing high-affinity copper ion transmembrane transporter activity Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity copper transporter activity|high affinity copper ion transmembrane transporter activity molecular_function owl:Class
GO:0018484 biolink:NamedThing 4-hydroxybenzaldehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+. got7fsn_ti p-hydroxybenzaldehyde dehydrogenase activity|3-hydroxybenzaldehyde:NAD+ oxidoreductase activity UM-BBD_reactionID:r0273|MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN|RHEA:20305|EC:1.2.1.64 molecular_function owl:Class
GO:0050244 biolink:NamedThing pyruvate oxidase (CoA-acetylating) activity Catalysis of the reaction: CoA + H(+) + O(2) + pyruvate = acetyl-CoA + CO(2) + H(2)O(2). got7fsn_ti pyruvate:oxygen 2-oxidoreductase (CoA-acetylating) EC:1.2.3.6|MetaCyc:PYRUVATE-OXIDASE-COA-ACETYLATING-RXN|RHEA:21912|KEGG_REACTION:R00211 molecular_function owl:Class
GO:0042697 biolink:NamedThing menopause Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Menopause biological_process owl:Class
GO:0034881 biolink:NamedThing citrazinate hydrolase activity Catalysis of the reaction: citrazinate + H2O = cis-aconitamide. got7fsn_ti UM-BBD_reactionID:r1343 molecular_function owl:Class
GO:0070788 biolink:NamedThing conidiophore stalk development The process whose specific outcome is the progression of the conidiophore stalk over time, from its formation to the mature structure. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. got7fsn_ti mah 2009-07-08T01:31:44Z biological_process owl:Class
GO:0140655 biolink:NamedThing mitochondrial proliferation The multiplication of mitochondria, resulting in the expansion of the number of mitochondria within a cell. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21537 pg 2021-06-04T10:23:02Z biological_process owl:Class
GO:0002758 biolink:NamedThing innate immune response-activating signal transduction A series of molecular signals generated as a consequence of a pathogen or microbial effector binding to a plant 'resistance-gene' receptor to activate a plant immune response, usually plant-type hypersensitive response. got7fsn_ti defense response signaling pathway, resistance gene-independent|effector-triggered immune signaling|effector-triggered immunity|defense response signalling pathway, resistance gene-dependent|defense response signaling pathway, resistance gene-dependent|defence response signalling pathway, resistance gene-dependent|defence response signaling pathway, resistance gene-independent|effector triggered immunity|defence response signalling pathway, resistance gene-independent|defence response signaling pathway, resistance gene-dependent https://github.com/geneontology/go-ontology/issues/18733|https://github.com/geneontology/go-ontology/issues/18587|https://github.com/geneontology/go-ontology/issues/19850|https://github.com/geneontology/go-ontology/issues/18586 GO:0010204|GO:0009870 biological_process owl:Class
GO:0002218 biolink:NamedThing activation of innate immune response Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species. got7fsn_ti GO:0002219 biological_process owl:Class
GO:0102588 biolink:NamedThing cyanidin 3-O-glucoside 6''-O-malonyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + malonyl-CoA <=> cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + coenzyme A. got7fsn_ti MetaCyc:RXN-15335|EC:2.3.1.171 molecular_function owl:Class
GO:0048451 biolink:NamedThing petal formation The process that gives rise to the petal. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048419 biological_process owl:Class
GO:0019928 biolink:NamedThing peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid. got7fsn_ti RESID:AA0314 biological_process owl:Class
GO:0003119 biolink:NamedThing regulation of vasoconstriction by neuronal epinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings. got7fsn_ti regulation of vasoconstriction by neuronal adrenaline biological_process owl:Class
GO:0003115 biolink:NamedThing regulation of vasoconstriction by epinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings. got7fsn_ti biological_process owl:Class
GO:0000823 biolink:NamedThing inositol-1,4,5-trisphosphate 6-kinase activity Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+). got7fsn_ti inositol polyphosphate multikinase activity|inositol trisphosphate 6-kinase activity|ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity|IpmK MetaCyc:2.7.1.151-RXN|EC:2.7.1.151|KEGG_REACTION:R05800 molecular_function owl:Class
GO:0051766 biolink:NamedThing inositol trisphosphate kinase activity Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. got7fsn_ti molecular_function owl:Class
GO:0006849 biolink:NamedThing plasma membrane pyruvate transport The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane. got7fsn_ti biological_process owl:Class
GO:1901475 biolink:NamedThing pyruvate transmembrane transport The directed movement of pyruvate across a membrane. got7fsn_ti pyruvate membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. tb 2012-10-04T20:52:54Z biological_process owl:Class
GO:0018042 biolink:NamedThing C-terminal peptidyl-histidine amidation The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0089 biological_process owl:Class
GO:0035739 biolink:NamedThing CD4-positive, alpha-beta T cell proliferation The expansion of a CD4-positive, alpha-beta T cell population by cell division. got7fsn_ti bf 2011-03-17T02:12:48Z biological_process owl:Class
GO:0046633 biolink:NamedThing alpha-beta T cell proliferation The expansion of an alpha-beta T cell population by cell division. got7fsn_ti alpha-beta T-cell proliferation|alpha-beta T-lymphocyte proliferation|alpha-beta T lymphocyte proliferation biological_process owl:Class
GO:0089717 biolink:NamedThing spanning component of membrane The component of a membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane. got7fsn_ti cellular_component owl:Class
GO:0016021 biolink:NamedThing integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to membrane|transmembrane Wikipedia:Transmembrane_protein cellular_component owl:Class
GO:0098979 biolink:NamedThing polyadic synapse A synapse consisting of a single presynapse and multiple postsynapses. These postsynapses may come from the same cell of from different cells. Polyadic synapses are common in arthropod and nematode central nervous systems. got7fsn_ti cellular_component owl:Class
GO:0045202 biolink:NamedThing synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. got7fsn_ti electrotonic synapse|mixed synapse|synaptic junction NIF_Subcellular:sao914572699|Wikipedia:Chemical_synapse cellular_component owl:Class
GO:0060262 biolink:NamedThing negative regulation of N-terminal protein palmitoylation Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein. got7fsn_ti biological_process owl:Class
GO:0050748 biolink:NamedThing negative regulation of lipoprotein metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. got7fsn_ti negative regulation of lipoprotein metabolism|down regulation of lipoprotein metabolic process|downregulation of lipoprotein metabolic process|down-regulation of lipoprotein metabolic process|inhibition of lipoprotein metabolic process biological_process owl:Class
GO:0010397 biolink:NamedThing apiogalacturonan metabolic process The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(1->3)-D-apiose) side chains via O-2 or O-3 links. got7fsn_ti apiogalacturonan metabolism biological_process owl:Class
GO:0009521 biolink:NamedThing photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. got7fsn_ti reaction center|reaction centre GO:0030090 Wikipedia:Photosystem cellular_component owl:Class
GO:0050407 biolink:NamedThing [glycogen-synthase-D] phosphatase activity Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate. got7fsn_ti uridine diphosphoglucose-glycogen glucosyltransferase phosphatase activity|UDP-glycogen glucosyltransferase phosphatase activity|UDP-glucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity|glycogen synthase D phosphatase activity|UDPglucose:glycogen 4-alpha-D-glucosyltransferase-D phosphohydrolase activity|glycogen synthase phosphatase activity|glycogen synthetase phosphatase activity|glycogen-synthase-D phosphatase activity|phosphatase type 2oC|Mg2+ dependent glycogen synthase phosphatase activity|glycogen glucosyltransferase phosphatase activity|UDPglucose-glycogen glucosyltransferase phosphatase activity EC:3.1.3.42|MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN molecular_function owl:Class
GO:0019065 biolink:NamedThing receptor-mediated endocytosis of virus by host cell Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell. got7fsn_ti receptor mediated endocytosis by host of virus particle|viral entry into host cell via receptor-mediated endocytosis|receptor mediated endocytosis of virus particle by host|virus receptor-mediated endocytosis by host|receptor-mediated endocytosis of virus by host|receptor mediated endocytosis of virus by host|viral receptor mediated endocytosis biological_process owl:Class
GO:0006898 biolink:NamedThing receptor-mediated endocytosis An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles. got7fsn_ti receptor mediated endocytosis Wikipedia:Receptor-mediated_endocytosis biological_process owl:Class
GO:0031241 biolink:NamedThing periplasmic side of cell outer membrane The side (leaflet) of the outer membrane that faces the periplasm of the cell. got7fsn_ti internal side of cell outer membrane|internal leaflet of cell outer membrane|internal side of outer membrane In GO, 'internal side' still refers to part of the membrane and does not refer to components beyond (inside of) the membrane. cellular_component owl:Class
GO:0098552 biolink:NamedThing side of membrane A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. got7fsn_ti dos 2013-12-03T11:28:04Z cellular_component owl:Class
GO:0048479 biolink:NamedThing style development The process whose specific outcome is the progression of the style over time, from its formation to the mature structure. The style is an elongated part of a carpel, or group of fused carpels, and it lies between the ovary and the stigma. got7fsn_ti biological_process owl:Class
GO:0035146 biolink:NamedThing tube fusion The joining of specific branches of a tubular system to form a continuous network. got7fsn_ti biological_process owl:Class
GO:0048674 biolink:NamedThing collateral sprouting of injured axon The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons. got7fsn_ti biological_process owl:Class
GO:0048668 biolink:NamedThing collateral sprouting The process in which outgrowths develop from the shafts of existing axons. got7fsn_ti axon branching biological_process owl:Class
GO:0090325 biolink:NamedThing regulation of locomotion involved in locomotory behavior Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. got7fsn_ti tb 2010-05-14T10:24:29Z biological_process owl:Class
GO:0016204 biolink:NamedThing determination of muscle attachment site The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site. got7fsn_ti biological_process owl:Class
GO:0071990 biolink:NamedThing maintenance of protein location to spindle pole body Any process in which a protein is maintained in a specific location at the spindle pole body, and is prevented from moving elsewhere. got7fsn_ti maintenance of protein location at spindle pole body|maintenance of protein location in spindle pole body mah 2010-10-25T11:02:31Z biological_process owl:Class
GO:0072595 biolink:NamedThing maintenance of protein localization in organelle Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle. got7fsn_ti maintenance of protein localization to organelle|maintenance of protein localisation to organelle mah 2011-02-14T02:09:13Z biological_process owl:Class
GO:0004334 biolink:NamedThing fumarylacetoacetase activity Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+). got7fsn_ti 4-fumarylacetoacetate fumarylhydrolase activity|beta-diketonase activity|fumarylacetoacetate hydrolase activity UM-BBD_reactionID:r0107|Reactome:R-HSA-71181|EC:3.7.1.2|KEGG_REACTION:R01364|MetaCyc:FUMARYLACETOACETASE-RXN|RHEA:10244 molecular_function owl:Class
GO:0071048 biolink:NamedThing nuclear retention of unspliced pre-mRNA at the site of transcription The process involved in retention of incorrectly or incompletely spliced pre-mRNA within the nucleus at the site of transcription. got7fsn_ti krc 2009-08-11T02:19:03Z biological_process owl:Class
GO:0071033 biolink:NamedThing nuclear retention of pre-mRNA at the site of transcription The process involved in retention of aberrant or improperly formed mRNAs, e.g. those that are incorrectly or incompletely spliced or that have incorrectly formed 3'-ends, within the nucleus at the site of transcription. got7fsn_ti krc 2009-07-28T04:35:54Z biological_process owl:Class
GO:0004924 biolink:NamedThing oncostatin-M receptor activity Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0043953 biolink:NamedThing protein transport by the Tat complex The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex. got7fsn_ti twin-arginine translocation pathway|protein secretion by the TAT complex|protein translocation by the twin-arginine translocation complex|protein translocation by the TAT complex Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'TAT protein translocation system complex ; GO:0033281'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. biological_process owl:Class
GO:0060063 biolink:NamedThing Spemann organizer formation at the embryonic shield Formation of the specialized region of the embryonic shield of the embryo that acts as the main signaling center establishing the teleost body plan. got7fsn_ti Spemann-Mangold organizer formation at the embryonic shield|Spemann's organizer formation at the embryonic shield Occurs in Teleost fish. biological_process owl:Class
GO:0060061 biolink:NamedThing Spemann organizer formation Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan. got7fsn_ti Spemann's organizer formation|Spemann-Mangold organizer formation biological_process owl:Class
GO:0016008 biolink:NamedThing major mitochondrial derivative The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20737 cellular_component owl:Class
GO:0042243 biolink:NamedThing asexual spore wall assembly The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species. got7fsn_ti asexual spore wall formation biological_process owl:Class
GO:0010213 biolink:NamedThing non-photoreactive DNA repair A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated. got7fsn_ti light-independent DNA repair biological_process owl:Class
GO:0006281 biolink:NamedThing DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. got7fsn_ti Wikipedia:DNA_repair biological_process owl:Class
GO:0042539 biolink:NamedThing hypotonic salinity response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. got7fsn_ti response to hypotonic salt stress biological_process owl:Class
GO:0006971 biolink:NamedThing hypotonic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell. got7fsn_ti hypo-osmotic response biological_process owl:Class
GO:0007463 biolink:NamedThing R2/R5 cell fate commitment The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres. got7fsn_ti biological_process owl:Class
GO:0102901 biolink:NamedThing isopimaradienol hydroxylase activity Catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 <=> isopimaradiene-diol + NADP + H2O. got7fsn_ti MetaCyc:RXN-8536 molecular_function owl:Class
GO:0050834 biolink:NamedThing molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide. got7fsn_ti RESID:AA0355 biological_process owl:Class
GO:0009271 biolink:NamedThing phage shock A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage. got7fsn_ti biological_process owl:Class
GO:0010456 biolink:NamedThing cell proliferation in dorsal spinal cord The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population. got7fsn_ti biological_process owl:Class
GO:0061578 biolink:NamedThing Lys63-specific deubiquitinase activity Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein. got7fsn_ti dph 2013-11-15T19:13:12Z Reactome:R-HSA-5691411|Reactome:R-HSA-741411|Reactome:R-HSA-8869506|Reactome:R-HSA-936390|Reactome:R-HSA-5690856|Reactome:R-HSA-5696547|Reactome:R-HSA-936381|Reactome:R-HSA-5357845|Reactome:R-HSA-5691439|Reactome:R-HSA-5691431|Reactome:R-HSA-688136 molecular_function owl:Class
GO:0101005 biolink:NamedThing deubiquitinase activity Catalysis of the hydrolysis of ubiquitin from proteins. got7fsn_ti ubiquitinyl hydrolase activity|deubiquitinase activity https://github.com/geneontology/go-ontology/issues/17398 There are two main classes of deubiquitinating enzymes: cysteine proteases (i.e., thiol dependent) and metalloproteases. mec 2016-02-08T09:39:38Z GO:1904265 Reactome:R-HSA-9674127 molecular_function owl:Class
GO:0051563 biolink:NamedThing smooth endoplasmic reticulum calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the smooth endoplasmic reticulum of a cell or between the smooth endoplasmic reticulum and its surroundings. got7fsn_ti smooth ER calcium ion concentration regulation|calcium ion homeostasis in smooth endoplasmic reticulum|regulation of calcium ion concentration in smooth ER|regulation of smooth ER calcium ion concentration|regulation of smooth endoplasmic reticulum calcium ion concentration|smooth endoplasmic reticulum calcium ion concentration regulation|regulation of calcium ion concentration in smooth endoplasmic reticulum|calcium ion homeostasis in smooth ER|smooth ER calcium ion homeostasis biological_process owl:Class
GO:0032469 biolink:NamedThing endoplasmic reticulum calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings. got7fsn_ti ER calcium ion concentration regulation|endoplasmic reticulum calcium ion concentration regulation|regulation of ER calcium ion concentration|regulation of calcium ion concentration in ER|regulation of endoplasmic reticulum calcium ion concentration|ER calcium ion homeostasis|regulation of calcium ion concentration in endoplasmic reticulum|calcium ion homeostasis in endoplasmic reticulum|calcium ion homeostasis in ER biological_process owl:Class
GO:0070757 biolink:NamedThing interleukin-35-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-35-mediated signalling pathway|IL-35-mediated signaling pathway mah 2009-06-23T01:55:02Z biological_process owl:Class
GO:0102096 biolink:NamedThing decaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate:dTDP-alpha-L-rhamnose rhamnosyltransferase activity Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + N-acetyl-alpha-D-glucosaminyl-diphospho-trans,octacis-decaprenol <=> dTDP(3-) + alpha-L-Rhap-(1->3)-alpha-D-GlcpNAc-1-diphospho-trans,octacis-decaprenol + H+. got7fsn_ti RHEA:34487|MetaCyc:RXN-11070|EC:2.4.1.289 molecular_function owl:Class
GO:1901440 biolink:NamedThing poly(hydroxyalkanoate) metabolic process The chemical reactions and pathways involving poly(hydroxyalkanoate). got7fsn_ti poly(hydroxyalkanoate) metabolism tt 2012-10-02T01:47:26Z biological_process owl:Class
GO:0017159 biolink:NamedThing pantetheine hydrolase activity Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine. got7fsn_ti vanin|(R)-pantetheine amidohydrolase activity|vanin-1|pantetheinase activity Reactome:R-HSA-8938300|EC:3.5.1.92|RHEA:13445|MetaCyc:3.5.1.92-RXN|KEGG_REACTION:R02973 molecular_function owl:Class
GO:0071279 biolink:NamedThing cellular response to cobalt ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. got7fsn_ti mah 2009-12-10T03:55:55Z biological_process owl:Class
GO:0032025 biolink:NamedThing response to cobalt ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus. got7fsn_ti biological_process owl:Class
GO:0102458 biolink:NamedThing cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> cyanin betaine + vanillate + H+. got7fsn_ti MetaCyc:RXN-13970|EC:2.4.1.299 molecular_function owl:Class
GO:0034725 biolink:NamedThing DNA replication-dependent nucleosome disassembly The controlled breakdown of nucleosomes on newly replicated DNA, coupled to strand elongation. got7fsn_ti biological_process owl:Class
GO:0008659 biolink:NamedThing (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O. got7fsn_ti (3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity|(3R)-hydroxymyristoyl-ACP dehydratase activity EC:4.2.1.59|RHEA:41892 molecular_function owl:Class
GO:0042441 biolink:NamedThing eye pigment metabolic process The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. got7fsn_ti eye pigment metabolism biological_process owl:Class
GO:0043324 biolink:NamedThing pigment metabolic process involved in developmental pigmentation The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism. got7fsn_ti pigment metabolism during developmental pigmentation|pigment metabolic process during developmental pigmentation biological_process owl:Class
GO:0004575 biolink:NamedThing sucrose alpha-glucosidase activity Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose. got7fsn_ti sucrose hydrolysis|beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis|sucrase activity|sucrose alpha-glucohydrolase activity|alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis|sucrase(invertase)|sucrose-alpha-D-glucohydrolase activity|intestinal sucrase activity|sucrose alpha-D-glucohydrolase activity|sucrase-isomaltase activity Reactome:R-HSA-5659926|Reactome:R-HSA-189069|RHEA:33795|MetaCyc:RXN-1461|KEGG_REACTION:R00802|EC:3.2.1.48 molecular_function owl:Class
GO:0004564 biolink:NamedThing beta-fructofuranosidase activity Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside. got7fsn_ti beta-D-fructofuranoside fructohydrolase activity|invertase activity|beta-h-fructosidase activity|invertin activity|fructosylinvertase activity|maxinvert L 1000 activity|acid invertase activity|glucosucrase activity|saccharase activity|beta-fructosidase activity|alkaline invertase activity MetaCyc:RXN-9985|EC:3.2.1.26 molecular_function owl:Class
GO:0008256 biolink:NamedThing protein histidine pros-kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine. got7fsn_ti ATP:protein-L-histidine N-pros-phosphotransferase activity|ATP:protein-L-histidine Npi-phosphotransferase activity|protein-histidine pros-kinase activity|HK2 RHEA:22720|EC:2.7.13.1|MetaCyc:2.7.13.1-RXN molecular_function owl:Class
GO:0004673 biolink:NamedThing protein histidine kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. got7fsn_ti HK1|EnvZ|histidine protein kinase activity|histidine kinase activity|protein kinase (histidine) (ambiguous)|Sln1p|ATP:protein-L-histidine N-phosphotransferase activity|histidine kinase (ambiguous)|protein-histidine kinase activity|HP165|histidine protein kinase (ambiguous)|protein histidine kinase (ambiguous)|protein kinase (histidine) GO:0008896 MetaCyc:2.7.13.3-RXN|EC:2.7.13.3 molecular_function owl:Class
GO:0090596 biolink:NamedThing sensory organ morphogenesis Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti tb 2014-08-22T13:23:20Z biological_process owl:Class
GO:0016581 biolink:NamedThing NuRD complex An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. got7fsn_ti NRD complex|nucleosome remodeling and histone deacetylation complex|Mi-2 complex cellular_component owl:Class
GO:0005667 biolink:NamedThing transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. got7fsn_ti nuclear transcription factor complex|cytoplasmic transcription factor complex|transcription factor complex jl 2013-08-28T12:11:37Z GO:0044798|GO:0044797 cellular_component owl:Class
GO:0033854 biolink:NamedThing glutamate-prephenate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-arogenate = L-glutamate + prephenate. got7fsn_ti L-arogenate:2-oxoglutarate aminotransferase activity|PAT|prephenate transaminase activity|L-glutamate:prephenate aminotransferase activity MetaCyc:PREPHENATE-TRANSAMINE-RXN|RHEA:22880|KEGG_REACTION:R07276|EC:2.6.1.79 molecular_function owl:Class
GO:0019263 biolink:NamedThing adamantanone catabolic process The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists. got7fsn_ti adamantanone catabolism|adamantanone breakdown|adamantanone degradation MetaCyc:P481-PWY biological_process owl:Class
GO:0098508 biolink:NamedThing endothelial to hematopoietic transition The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium. got7fsn_ti dos 2013-09-24T15:20:39Z biological_process owl:Class
GO:0099643 biolink:NamedThing signal release from synapse Any signal release from a synapse. got7fsn_ti biological_process owl:Class
GO:0018547 biolink:NamedThing nitroglycerin reductase activity Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative. got7fsn_ti NG reductase activity UM-BBD_enzymeID:e0038 molecular_function owl:Class
GO:0016663 biolink:NamedThing oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen. got7fsn_ti EC:1.7.3.- molecular_function owl:Class
GO:0007344 biolink:NamedThing pronuclear fusion The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome. got7fsn_ti biological_process owl:Class
GO:0000741 biolink:NamedThing karyogamy The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. got7fsn_ti nuclear fusion during karyogamy|nuclear fusion GO:0007335 Wikipedia:Karyogamy biological_process owl:Class
GO:0009991 biolink:NamedThing response to extracellular stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus. got7fsn_ti biological_process owl:Class
GO:0034674 biolink:NamedThing integrin alpha5-beta1 complex An integrin complex that comprises one alpha5 subunit and one beta1 subunit. got7fsn_ti VLA-5 complex|alpha5-beta1 integrin complex|ITGA5-ITGB1 complex cellular_component owl:Class
GO:0039008 biolink:NamedThing pronephric nephron tubule morphogenesis The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron. got7fsn_ti bf 2010-07-02T09:45:55Z biological_process owl:Class
GO:0099576 biolink:NamedThing regulation of protein catabolic process at postsynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0042176 biolink:NamedThing regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. got7fsn_ti regulation of protein degradation|regulation of protein catabolism|regulation of protein breakdown biological_process owl:Class
GO:0071674 biolink:NamedThing mononuclear cell migration The movement of a mononuclear cell within or between different tissues and organs of the body. got7fsn_ti mah 2010-02-16T02:11:00Z biological_process owl:Class
GO:0034265 biolink:NamedThing isopentenyl adenine biosynthetic process The chemical reactions and pathways resulting in the formation of the cytokinin 6-isopentenyladenine. got7fsn_ti isopentenyl adenine anabolism|isopentenyl adenine biosynthesis|isopentenyl adenine formation|isopentenyladenine biosynthetic process|isopentenyl adenine synthesis biological_process owl:Class
GO:0009691 biolink:NamedThing cytokinin biosynthetic process The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. got7fsn_ti cytokinin synthesis|cytokinin formation|cytokinin biosynthesis|cytokinin anabolism biological_process owl:Class
GO:0000271 biolink:NamedThing polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. got7fsn_ti polysaccharide synthesis|polysaccharide formation|polysaccharide anabolism|glycan biosynthesis|polysaccharide biosynthesis|glycan biosynthetic process biological_process owl:Class
GO:0005976 biolink:NamedThing polysaccharide metabolic process The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. got7fsn_ti polysaccharide metabolism|glycan metabolism|multicellular organismal polysaccharide metabolic process|glycan metabolic process GO:0044263 biological_process owl:Class
GO:0001196 biolink:NamedThing regulation of mating-type specific transcription from RNA polymerase II promoter Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti krc 2011-11-23T09:25:32Z biological_process owl:Class
GO:0019708 biolink:NamedThing peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins. got7fsn_ti peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine|peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine|peptidyl-glycine cholesteryl ester formation from peptidyl-glycine RESID:AA0309 biological_process owl:Class
GO:0008203 biolink:NamedThing cholesterol metabolic process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. got7fsn_ti cholesterol metabolism biological_process owl:Class
GO:0002483 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. got7fsn_ti endogenous peptide antigen processing and presentation biological_process owl:Class
GO:0048002 biolink:NamedThing antigen processing and presentation of peptide antigen The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. got7fsn_ti peptide antigen processing and presentation|antigen presentation, peptide antigen biological_process owl:Class
GO:0050801 biolink:NamedThing ion homeostasis Any process involved in the maintenance of an internal steady state of ions within an organism or cell. got7fsn_ti negative regulation of crystal formation|electrolyte homeostasis|regulation of ion homeostasis GO:2000021 biological_process owl:Class
GO:0051073 biolink:NamedThing adenosylcobinamide-GDP ribazoletransferase activity Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin. got7fsn_ti adenosylcobinamide-GDP:alpha-ribazole ribazoletransferase activity|cobalamin-5'-phosphate synthase activity|cobalamin (5'-phosphate) synthase activity|cobalamin synthase activity|CobS MetaCyc:COBALAMINSYN-RXN|EC:2.7.8.26|RHEA:16049 molecular_function owl:Class
GO:0072069 biolink:NamedThing DCT cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the kidney as it progresses from its formation to the mature state. got7fsn_ti distal convoluted tubule cell differentiation mah 2010-01-25T04:17:22Z biological_process owl:Class
GO:0061005 biolink:NamedThing cell differentiation involved in kidney development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the kidney as it progresses from its formation to the mature state. got7fsn_ti dph 2010-01-21T09:13:55Z biological_process owl:Class
GO:0051310 biolink:NamedThing metaphase plate congression The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle. got7fsn_ti chromosome congression biological_process owl:Class
GO:0032885 biolink:NamedThing regulation of polysaccharide biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides. got7fsn_ti biological_process owl:Class
GO:0050182 biolink:NamedThing phosphate butyryltransferase activity Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA. got7fsn_ti butanoyl-CoA:phosphate butanoyltransferase activity|phosphotransbutyrylase activity KEGG_REACTION:R01174|MetaCyc:PHOSPHATE-BUTYRYLTRANSFERASE-RXN|EC:2.3.1.19|RHEA:20892 molecular_function owl:Class
GO:0033708 biolink:NamedThing isocitrate-homoisocitrate dehydrogenase activity Catalysis of the reactions: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH, and (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+. got7fsn_ti isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating) activity|homoisocitrate-isocitrate dehydrogenase activity|PH1722 EC:1.1.1.286|MetaCyc:RXN-7969 molecular_function owl:Class
GO:0047769 biolink:NamedThing arogenate dehydratase activity Catalysis of the reaction: L-arogenate = L-phenylalanine + H2O + CO2. got7fsn_ti L-arogenate hydro-lyase (decarboxylating)|L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)|carboxycyclohexadienyl dehydratase activity MetaCyc:CARBOXYCYCLOHEXADIENYL-DEHYDRATASE-RXN|EC:4.2.1.91|RHEA:12536 molecular_function owl:Class
GO:0033879 biolink:NamedThing acetylajmaline esterase activity Catalysis of the reactions: 17-O-acetylajmaline + H2O = ajmaline + acetate, and 17-O-acetylnorajmaline + H2O = norajmaline + acetate. got7fsn_ti 2beta(R)-17-O-acetylajmalan:acetylesterase activity|AAE|acetylajmalan esterase activity|17-O-acetylajmaline O-acetylhydrolase activity MetaCyc:RXN-8652|MetaCyc:RXN-8653|EC:3.1.1.80 molecular_function owl:Class
GO:1900581 biolink:NamedThing (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process The chemical reactions and pathways resulting in the formation of (17Z)-protosta-17(20),24-dien-3beta-ol. got7fsn_ti (17Z)-protosta-17(20),24-dien-3beta-ol formation|(17Z)-protosta-17(20),24-dien-3beta-ol synthesis|(17Z)-protosta-17(20),24-dien-3beta-ol anabolism|(17Z)-protosta-17(20),24-dien-3beta-ol biosynthesis di 2012-05-15T06:47:38Z biological_process owl:Class
GO:1990133 biolink:NamedThing molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex A heterodimeric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin (MPT) cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; Moco biosynthesis and its constituent molecules are evolutionarily conserved. got7fsn_ti bhm 2013-06-26T10:54:21Z cellular_component owl:Class
GO:0042247 biolink:NamedThing establishment of planar polarity of follicular epithelium Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates. got7fsn_ti biological_process owl:Class
GO:0080029 biolink:NamedThing cellular response to boron-containing substance levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of boron-containing substances. got7fsn_ti cellular response to boron levels biological_process owl:Class
GO:0070887 biolink:NamedThing cellular response to chemical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. mah 2009-08-27T04:41:45Z biological_process owl:Class
GO:1905169 biolink:NamedThing regulation of protein localization to phagocytic vesicle Any process that modulates the frequency, rate or extent of protein localization to phagocytic vesicle. got7fsn_ti regulation of protein localization in phagocytic vesicle|regulation of protein localisation to phagocytic vesicle|regulation of protein recruitment to phagosome|regulation of protein localisation to phagosome|regulation of protein localisation in phagocytic vesicle bf 2016-05-02T18:38:13Z biological_process owl:Class
GO:0031863 biolink:NamedThing prostaglandin D2 receptor binding Binding to a prostaglandin D2 receptor. got7fsn_ti prostaglandin D2 receptor ligand|prostanoid DP receptor binding molecular_function owl:Class
GO:1990130 biolink:NamedThing GATOR1 complex A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. got7fsn_ti SEACIT complex|IML1 complex https://github.com/geneontology/go-ontology/issues/21778 The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131. rb 2013-06-25T17:34:40Z cellular_component owl:Class
GO:0106237 biolink:NamedThing arachidonate 12(R)-lipoxygenase activity Catalysis of the reaction: arachidonate + O(2)=(5Z,8Z,10E,12R,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. got7fsn_ti hjd 2019-12-18T21:03:02Z RHEA:41336 molecular_function owl:Class
GO:0042832 biolink:NamedThing defense response to protozoan Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism. got7fsn_ti defense response to protozoan, incompatible interaction|defence response to protozoon|defence response to protozoa|resistance response to pathogenic protozoa|defense response to protozoon|defense response to protozoa|defense response to pathogenic protozoa|resistance response to pathogenic protozoan|defence response to pathogenic protozoa GO:0009818 biological_process owl:Class
GO:0001562 biolink:NamedThing response to protozoan Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. got7fsn_ti response to protozoon|response to protozoa|resistance to pathogenic protozoa GO:0042833 biological_process owl:Class
GO:0090717 biolink:NamedThing adaptive immune memory response involving T cells and B cells An immune response mediated by reactivated memory T cells and B cells and directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response. got7fsn_ti tb 2016-11-11T12:35:19Z biological_process owl:Class
GO:0002460 biolink:NamedThing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. got7fsn_ti biological_process owl:Class
GO:0001326 biolink:NamedThing replication of extrachromosomal circular DNA Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication. got7fsn_ti biological_process owl:Class
GO:2000385 biolink:NamedThing positive regulation of ectoderm development Any process that activates or increases the frequency, rate or extent of ectoderm development. got7fsn_ti vk 2011-02-15T03:17:39Z biological_process owl:Class
GO:0002942 biolink:NamedThing tRNA m2,2-guanine biosynthesis The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position. got7fsn_ti hjd 2012-11-16T16:07:20Z biological_process owl:Class
GO:0048094 biolink:NamedThing male pigmentation Establishment of a pattern of pigment in males. got7fsn_ti biological_process owl:Class
GO:0003331 biolink:NamedThing positive regulation of extracellular matrix constituent secretion Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells. got7fsn_ti dph 2009-11-02T02:11:22Z biological_process owl:Class
GO:1903532 biolink:NamedThing positive regulation of secretion by cell Any process that activates or increases the frequency, rate or extent of secretion by cell. got7fsn_ti upregulation of secretion by cell|upregulation of cellular secretion|activation of cellular secretion|up regulation of secretion by cell|up regulation of cellular secretion|positive regulation of cellular secretion|up-regulation of cellular secretion|activation of secretion by cell|up-regulation of secretion by cell pm 2014-10-08T13:25:17Z biological_process owl:Class
GO:0018282 biolink:NamedThing metal incorporation into metallo-sulfur cluster The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide. got7fsn_ti metal incorporation into metallo-sulphur cluster biological_process owl:Class
GO:0002110 biolink:NamedThing cotranscriptional mitochondrial rRNA nucleotide insertion The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis. got7fsn_ti biological_process owl:Class
GO:0030327 biolink:NamedThing prenylated protein catabolic process The chemical reactions and pathways resulting in the breakdown of prenylated proteins. got7fsn_ti prenylated protein breakdown|prenylated protein degradation|prenylated protein catabolism biological_process owl:Class
GO:0019941 biolink:NamedThing modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. got7fsn_ti modification-dependent protein breakdown|protein degradation tagging activity|modification-dependent proteolysis|protein-ligand-dependent protein catabolic process|protein-ligand-dependent protein catabolism|modification-initiated proteolysis|modification-dependent protein catabolism|modification-initiated protein catabolism|modification-initiated protein catabolic process|modification-dependent protein degradation biological_process owl:Class
GO:0036161 biolink:NamedThing calcitonin secretion The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell. got7fsn_ti bf 2012-03-26T01:30:32Z biological_process owl:Class
GO:0016029 biolink:NamedThing subrhabdomeral cisterna A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase. got7fsn_ti submicrovillar cisterna|SMC cellular_component owl:Class
GO:0120082 biolink:NamedThing smooth endoplasmic reticulum cisterna A subcompartment of the smooth endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity. got7fsn_ti krc 2017-07-05T23:32:11Z cellular_component owl:Class
GO:0045792 biolink:NamedThing negative regulation of cell size Any process that reduces cell size. got7fsn_ti down-regulation of cell size|down regulation of cell size|inhibition of cell size|downregulation of cell size biological_process owl:Class
GO:0008361 biolink:NamedThing regulation of cell size Any process that modulates the size of a cell. got7fsn_ti cell size control biological_process owl:Class
GO:0035323 biolink:NamedThing male germline ring canal An intercellular bridge that connects the germline cells of a male cyst. got7fsn_ti spermatocyte ring canal|testicular ring canal bf 2010-02-25T11:05:14Z cellular_component owl:Class
GO:0045172 biolink:NamedThing germline ring canal Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells. got7fsn_ti cellular_component owl:Class
GO:0106330 biolink:NamedThing sialate 9-O-acetylesterase activity Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-acetylneuraminate. got7fsn_ti hjd 2020-09-30T19:38:44Z RHEA:22600|EC:3.1.1.53 molecular_function owl:Class
GO:0034609 biolink:NamedThing spicule insertion Insertion of the male copulatory spicules into the hermaphrodite. Spicule insertion behavior initiates when the male cloaca contacts the vulva. During most mating encounters, the spicule tips will prod the vulva continuously until they partially penetrate, which then causes the protractors to contract completely so that the spicules extend through the vulva. got7fsn_ti biological_process owl:Class
GO:0014825 biolink:NamedThing stomach fundus smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch. got7fsn_ti biological_process owl:Class
GO:0014847 biolink:NamedThing proximal stomach smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach. got7fsn_ti biological_process owl:Class
GO:0034439 biolink:NamedThing lipoprotein lipid oxidation The modification of a lipoprotein by oxidation of the lipid group. got7fsn_ti biological_process owl:Class
GO:0034440 biolink:NamedThing lipid oxidation The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. got7fsn_ti biological_process owl:Class
GO:0045940 biolink:NamedThing positive regulation of steroid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids. got7fsn_ti up regulation of steroid metabolic process|stimulation of steroid metabolic process|upregulation of steroid metabolic process|positive regulation of steroid metabolism|up-regulation of steroid metabolic process|activation of steroid metabolic process biological_process owl:Class
GO:0045834 biolink:NamedThing positive regulation of lipid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids. got7fsn_ti activation of lipid metabolic process|upregulation of lipid metabolic process|up-regulation of lipid metabolic process|stimulation of lipid metabolic process|positive regulation of lipid metabolism|up regulation of lipid metabolic process biological_process owl:Class
GO:0035909 biolink:NamedThing aorta morphogenesis The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. got7fsn_ti bf 2011-06-24T11:11:11Z biological_process owl:Class
GO:0070915 biolink:NamedThing lysophosphatidic acid receptor activity Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti LPA receptor activity mah 2009-09-10T05:05:13Z molecular_function owl:Class
GO:0045125 biolink:NamedThing bioactive lipid receptor activity Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. got7fsn_ti molecular_function owl:Class
GO:0005927 biolink:NamedThing muscle tendon junction A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons. got7fsn_ti myotendinous junction cellular_component owl:Class
GO:0030055 biolink:NamedThing cell-substrate junction A cell junction that forms a connection between a cell and the extracellular matrix. got7fsn_ti cell-matrix junction cellular_component owl:Class
GO:0022835 biolink:NamedThing transmitter-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts. got7fsn_ti neurotransmitter-gated channel activity|extracellular substance gated channel activity molecular_function owl:Class
GO:0022834 biolink:NamedThing ligand-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti molecular_function owl:Class
GO:0005977 biolink:NamedThing glycogen metabolic process The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages. got7fsn_ti glycogen metabolism biological_process owl:Class
GO:0006112 biolink:NamedThing energy reserve metabolic process The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. got7fsn_ti energy reserve metabolism biological_process owl:Class
GO:0035869 biolink:NamedThing ciliary transition zone A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm. got7fsn_ti connecting cilium|cilial transition zone|cilium transition zone Depending on the species, this region may have a distinct geometrically shaped electron-dense structure within the axonemal lumen visible in electron microscopy images; most animals don't display this inner structure. The axoneme extends through the ciliary transition zone, but only consists of the outer doublets. The central pair, axonemal spokes, and dynein complexes are not found in this part of the ciliary shaft. Note that the connecting cilium of the photoreceptor cells is thought to be equivalent to the transition zone. bf 2011-05-25T03:09:58Z cellular_component owl:Class
GO:0047011 biolink:NamedThing 2-dehydropantolactone reductase (A-specific) activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+. got7fsn_ti 2-dehydropantoyl-lactone reductase (A-specific) activity|ketopantoyl lactone reductase activity|(R)-pantolactone:NADP+ oxidoreductase (A-specific)|2-ketopantoyl lactone reductase activity|2-oxopantoyl lactone reductase MetaCyc:1.1.1.168-RXN|EC:1.1.1.168 molecular_function owl:Class
GO:0010629 biolink:NamedThing negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. got7fsn_ti This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. biological_process owl:Class
GO:0072242 biolink:NamedThing metanephric DCT cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric distal convoluted tubule cell. got7fsn_ti metanephric distal convoluted tubule cell fate commitment mah 2010-03-19T03:27:00Z biological_process owl:Class
GO:0072146 biolink:NamedThing DCT cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a distal convoluted tubule cell. got7fsn_ti distal convoluted tubule cell fate commitment mah 2010-02-24T01:59:04Z biological_process owl:Class
GO:0060138 biolink:NamedThing fetal process involved in parturition A reproductive process occurring in the embryo that results in birth. got7fsn_ti biological_process owl:Class
GO:0020008 biolink:NamedThing rhoptry A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole. got7fsn_ti paired organelles|toxoneme Wikipedia:Rhoptry cellular_component owl:Class
GO:0032808 biolink:NamedThing lacrimal gland development The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. got7fsn_ti biological_process owl:Class
GO:0030076 biolink:NamedThing light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. got7fsn_ti antenna complex Wikipedia:Light-harvesting_complex cellular_component owl:Class
GO:0016554 biolink:NamedThing cytidine to uridine editing The conversion of a cytosine residue to uridine in an RNA molecule by deamination. got7fsn_ti biological_process owl:Class
GO:0016553 biolink:NamedThing base conversion or substitution editing Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s). got7fsn_ti base conversion/substitution editing biological_process owl:Class
GO:0050745 biolink:NamedThing peptide cross-linking via L-cysteinyl-5-imidazolinone glycine The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water. got7fsn_ti RESID:AA0188 biological_process owl:Class
GO:0043915 biolink:NamedThing L-seryl-tRNA(Sec) kinase activity Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec). got7fsn_ti O-phosphoseryl-tRNA(Sec) kinase activity MetaCyc:RXN-10038|EC:2.7.1.164|RHEA:25037 molecular_function owl:Class
GO:0018480 biolink:NamedThing 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+. got7fsn_ti 5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity|carboxymethylhydroxymuconic semialdehyde dehydrogenase activity EC:1.2.1.60|RHEA:15681|UM-BBD_reactionID:r0365|MetaCyc:CHMS-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0060230 biolink:NamedThing lipoprotein lipase activator activity Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein. got7fsn_ti molecular_function owl:Class
GO:0045581 biolink:NamedThing negative regulation of T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation. got7fsn_ti negative regulation of T-lymphocyte differentiation|down regulation of T cell differentiation|inhibition of T cell differentiation|negative regulation of T cell development|negative regulation of T-cell differentiation|negative regulation of T lymphocyte differentiation|downregulation of T cell differentiation|down-regulation of T cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0045580 biolink:NamedThing regulation of T cell differentiation Any process that modulates the frequency, rate or extent of T cell differentiation. got7fsn_ti regulation of T-cell differentiation|regulation of T lymphocyte differentiation|regulation of T-lymphocyte differentiation|regulation of T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0030850 biolink:NamedThing prostate gland development The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. got7fsn_ti prostate development biological_process owl:Class
GO:0015313 biolink:NamedThing fluconazole:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out). got7fsn_ti fluconazole:hydrogen antiporter activity molecular_function owl:Class
GO:0045119 biolink:NamedThing azole:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances. got7fsn_ti bicyclomycin/sulfathiazole:hydrogen antiporter activity|azole:hydrogen antiporter activity molecular_function owl:Class
GO:0021825 biolink:NamedThing substrate-dependent cerebral cortex tangential migration The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions. got7fsn_ti biological_process owl:Class
GO:0021800 biolink:NamedThing cerebral cortex tangential migration The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. got7fsn_ti biological_process owl:Class
GO:0021742 biolink:NamedThing abducens nucleus development The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0097218 biolink:NamedThing sieve plate A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas. got7fsn_ti Typical of angiosperms. Part of sieve tube member (PO:0000289). pr 2012-01-13T05:42:48Z cellular_component owl:Class
GO:1902556 biolink:NamedThing phosphatidylinositol transporter complex A protein complex which is capable of phosphatidylinositol transporter activity. got7fsn_ti Ire1 complex dimer|Ire1 complex homooligomer|Ire1 complex homodimer An example is PDR16 in S. cerevisiae (UniProt ID P53860) in PMID:9890948 (inferred from direct assay). bhm 2013-12-06T16:12:25Z cellular_component owl:Class
GO:1990351 biolink:NamedThing transporter complex A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. got7fsn_ti An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). bhm 2014-03-26T14:23:27Z cellular_component owl:Class
GO:0044833 biolink:NamedThing modulation by virus of host protein transport Any viral process that modulates the frequency, rate or extent of protein transport in its host organism. got7fsn_ti jl 2014-02-06T13:25:52Z biological_process owl:Class
GO:0032036 biolink:NamedThing myosin heavy chain binding Binding to a heavy chain of a myosin complex. got7fsn_ti molecular_function owl:Class
GO:0033938 biolink:NamedThing 1,6-alpha-L-fucosidase activity Catalysis of the hydrolysis of (1->6) linkages between alpha-L-fucose and N-acetyl-D-glucosamine in glycopeptides such as immunoglobulin G glycopeptide and fucosyl-asialo-agalacto-fetuin. got7fsn_ti 1,6-L-fucosyl-N-acetyl-D-glucosaminylglycopeptide fucohydrolase activity EC:3.2.1.127|MetaCyc:3.2.1.127-RXN molecular_function owl:Class
GO:0004560 biolink:NamedThing alpha-L-fucosidase activity Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. got7fsn_ti alpha-fucosidase activity|alpha-L-fucoside fucohydrolase activity RHEA:12288|MetaCyc:ALPHA-L-FUCOSIDASE-RXN|Reactome:R-HSA-5693807|EC:3.2.1.51 molecular_function owl:Class
GO:0048464 biolink:NamedThing flower calyx development The process whose specific outcome is the progression of the flower calyx over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0048438 biolink:NamedThing floral whorl development The process whose specific outcome is the progression of a floral whorl over time, from its formation to the mature structure. A floral whorl is a circular arrangement of parts of a flower arising from a stem of a plant. got7fsn_ti collective phyllome structure development Consider instead annotating to one of the more specific child terms, or to 'floral organ development ; GO:0048438' or one of its child terms. GO:0048413 biological_process owl:Class
GO:0090713 biolink:NamedThing immunological memory process Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory. got7fsn_ti tb 2016-11-11T12:20:30Z biological_process owl:Class
GO:0004315 biolink:NamedThing 3-oxoacyl-[acyl-carrier-protein] synthase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. got7fsn_ti beta-ketoacyl-acyl carrier protein synthase activity|beta-ketoacyl-acyl-carrier-protein synthase I|beta-ketoacyl synthetase activity|beta-ketoacylsynthase activity|beta-ketoacyl-ACP synthetase activity|acyl-malonyl acyl carrier protein-condensing enzyme activity|beta-ketoacyl-ACP synthase I activity|beta-ketoacyl-acyl-carrier-protein synthase II activity|fatty acid condensing enzyme activity|ketoacyl-ACP synthase activity|beta-ketoacyl-ACP synthase II activity|3-oxoacyl-acyl-carrier-protein synthase activity|KAS I activity|acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)|KASI|acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity|3-ketoacyl-acyl carrier protein synthase activity|beta-ketoacyl acyl carrier protein synthase activity|beta-ketoacyl-[acyl carrier protein] synthase activity|condensing enzyme activity|KAS II|KASII|3-oxoacyl-ACP synthase activity|3-oxoacyl-acyl carrier protein synthase I activity|beta-ketoacyl-acyl carrier protein synthetase activity|3-oxoacyl-[acyl-carrier protein] synthase activity|3-oxoacyl:ACP synthase I https://github.com/geneontology/go-ontology/issues/21801 GO:0033817 MetaCyc:2.3.1.179-RXN|EC:2.3.1.179|EC:2.3.1.41|MetaCyc:3-OXOACYL-ACP-SYNTH-RXN|RHEA:22836 molecular_function owl:Class
GO:0000349 biolink:NamedThing generation of catalytic spliceosome for first transesterification step Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome. got7fsn_ti spliceosomal C1 complex biosynthesis|formation of catalytic spliceosome for first transesterification step|catalytic spliceosome assembly for first transesterification step|spliceosomal A2-2 complex formation|spliceosomal C1 complex formation|U12-type catalytic spliceosome formation for first transesterification step|U2-type catalytic spliceosome formation for first transesterification step|spliceosomal A2-2 complex biosynthesis Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian). GO:0000357|GO:0000356 biological_process owl:Class
GO:0022618 biolink:NamedThing ribonucleoprotein complex assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. got7fsn_ti RNA-protein complex assembly|protein-RNA complex assembly|RNP complex assembly biological_process owl:Class
GO:0006508 biolink:NamedThing proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. got7fsn_ti peptidolysis|ATP-dependent proteolysis This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. Wikipedia:Proteolysis biological_process owl:Class
GO:0031030 biolink:NamedThing negative regulation of septation initiation signaling Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling. got7fsn_ti negative regulation of septation initiation signalling|negative regulation of septation initiation network|negative regulation of septation initiation signaling cascade|downregulation of septation initiation signaling|down regulation of septation initiation signaling|down-regulation of septation initiation signaling|inhibition of septation initiation signaling biological_process owl:Class
GO:0010974 biolink:NamedThing negative regulation of division septum assembly Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. got7fsn_ti negative regulation of division septum formation|inhibition of division septum assembly involved in cell cycle cytokinesis tb 2009-06-01T10:32:32Z GO:1901139|GO:1902469 biological_process owl:Class
GO:0047077 biolink:NamedThing Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity Catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin. got7fsn_ti Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)|Photinus luciferin 4-monooxygenase (adenosine triphosphate-hydrolyzing)|Photinus-luciferin:oxygen 4-oxidoreductase (decarboxylating, ATP-hydrolysing)|luciferase (firefly luciferin)|firefly luciferase activity|luciferase activity|firefly luciferin luciferase activity|Photinus pyralis luciferase activity EC:1.13.12.7|RHEA:10732|MetaCyc:1.13.12.7-RXN molecular_function owl:Class
GO:0034804 biolink:NamedThing benzo(a)pyrene 11,12-epoxidase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide. got7fsn_ti UM-BBD_reactionID:r1119 molecular_function owl:Class
GO:0032883 biolink:NamedThing regulation of chitin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin. got7fsn_ti regulation of chitin formation|regulation of chitin biosynthesis|regulation of chitin synthesis|regulation of chitin anabolism biological_process owl:Class
GO:0017199 biolink:NamedThing N-terminal peptidyl-threonine acetylation The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase. got7fsn_ti See also the molecular function term 'peptide alpha-N-acetyltransferase activity ; GO:0004596'. RESID:AA0052 biological_process owl:Class
GO:0120257 biolink:NamedThing peptidyl-threonine acetylation The acetylation of peptidyl-threonine. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19957 krc 2020-09-08T18:01:01Z biological_process owl:Class
GO:0097027 biolink:NamedThing ubiquitin-protein transferase activator activity Binds to and increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. got7fsn_ti pr 2011-03-31T05:19:23Z molecular_function owl:Class
GO:0055106 biolink:NamedThing ubiquitin-protein transferase regulator activity Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. got7fsn_ti molecular_function owl:Class
GO:0036244 biolink:NamedThing cellular response to neutral pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti bf 2012-05-28T10:21:03Z biological_process owl:Class
GO:0071467 biolink:NamedThing cellular response to pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti mah 2009-12-18T11:41:54Z biological_process owl:Class
GO:0050177 biolink:NamedThing phenylpyruvate decarboxylase activity Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2. got7fsn_ti phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)|phenylpyruvate carboxy-lyase activity RHEA:14185|EC:4.1.1.43|MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN molecular_function owl:Class
GO:0102366 biolink:NamedThing 7-beta-hydroxytaxusin 2-alpha-hydroxylase activity Catalysis of the reaction: 7-beta-hydroxytaxusin + NADPH + O2 + H+ = 2alpha, 7-beta-dihydroxytaxusin + NADP + H2O. got7fsn_ti MetaCyc:RXN-13487 molecular_function owl:Class
GO:0051754 biolink:NamedThing meiotic sister chromatid cohesion, centromeric The cell cycle process in which centromeres of sister chromatids are joined during meiosis. got7fsn_ti sister chromatid cohesion at centromere at meiosis I|meiotic sister chromatid cohesion at centromere|centromeric meiotic sister chromatin cohesion biological_process owl:Class
GO:0070601 biolink:NamedThing centromeric sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome. got7fsn_ti sister chromatid cohesion at centromere mah 2009-04-28T04:31:00Z biological_process owl:Class
GO:0043565 biolink:NamedThing sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. got7fsn_ti sequence specific DNA binding molecular_function owl:Class
GO:0003677 biolink:NamedThing DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). got7fsn_ti microtubule/chromatin interaction|plasmid binding|structure specific DNA binding|structure-specific DNA binding GO:0043566 molecular_function owl:Class
GO:0044481 biolink:NamedThing envenomation resulting in proteolysis in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism. got7fsn_ti jl 2012-01-19T03:01:16Z biological_process owl:Class
GO:0102432 biolink:NamedThing quercetin 7-O-methyltransferase activity Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine <=> rhamnetin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13906 molecular_function owl:Class
GO:0044717 biolink:NamedThing 8-hydroxy-dADP phosphatase activity Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate. got7fsn_ti jl 2012-10-18T13:33:32Z Reactome:R-HSA-2395965 molecular_function owl:Class
GO:0017110 biolink:NamedThing nucleoside-diphosphatase activity Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. got7fsn_ti NDPase activity|inosine diphosphatase|nucleoside-diphosphate phosphohydrolase activity|nucleoside diphosphatase activity|inosine 5'-diphosphatase|nucleoside diphosphate phosphohydrolase activity|apyrase activity|nucleoside diphosphate phosphatase activity|nucleoside 5'-diphosphatase activity|type L nucleoside diphosphatase|type B nucleoside diphosphatase Reactome:R-HSA-8851129|Reactome:R-HSA-8851550|Reactome:R-HSA-8851356|MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN|Reactome:R-HSA-2395876|EC:3.6.1.6|Reactome:R-HSA-8850854|RHEA:36799|Reactome:R-HSA-8851225|Reactome:R-HSA-8851396 molecular_function owl:Class
GO:0031508 biolink:NamedThing pericentric heterochromatin assembly The assembly of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of centromeric DNA. got7fsn_ti centromeric silencing|centromeric heterochromatin formation|chromatin silencing at pericentric region|heterochromatic silencing at centromere|centromeric heterochromatin biosynthesis|chromatin silencing at centromere|centric heterochromatin formation|centromere chromatin silencing|chromatin silencing at centromere outer repeat region https://github.com/geneontology/go-ontology/issues/18954|https://github.com/geneontology/go-ontology/issues/19112 mah 2013-07-17T15:21:38Z GO:1990141|GO:0030702 biological_process owl:Class
GO:0047206 biolink:NamedThing UDP-N-acetylmuramoylpentapeptide-lysine N6-alanyltransferase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + L-alanyl-tRNA = UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNA. got7fsn_ti L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine 6-N-alanyltransferase activity|UDP-N-acetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity|alanyl-transfer ribonucleate-uridine diphosphoacetylmuramoylpentapeptide transferase activity|uridine diphosphoacetylmuramoylpentapeptide lysine N(6)-alanyltransferase activity|UDP-N-acetylmuramoylpentapeptide lysine N6-alanyltransferase activity|uridine diphosphoacetylmuramoylpentapeptide lysine N6-alanyltransferase activity|L-alanyl-tRNA:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine N6-alanyltransferase activity MetaCyc:2.3.2.10-RXN|RHEA:12432|EC:2.3.2.10 molecular_function owl:Class
GO:0016755 biolink:NamedThing aminoacyltransferase activity Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring amino-acyl groups|aminoacyltransferase activity EC:2.3.2.- molecular_function owl:Class
GO:0051427 biolink:NamedThing hormone receptor binding Binding to a receptor for a hormone. got7fsn_ti molecular_function owl:Class
GO:0102376 biolink:NamedThing lupeol 28-oxidase activity Catalysis of the reaction: lupeol + 3 NADPH + 3 O2 + 3 H+ <=> betulinic acid + 3 NADP + 4 H2O. got7fsn_ti MetaCyc:RXN-13507 molecular_function owl:Class
GO:0042824 biolink:NamedThing MHC class I peptide loading complex A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules. got7fsn_ti PLC|peptide-loading complex Note that although this complex is located in the endoplasmic reticulum, there is some evidence that it may also be found in the Golgi. cellular_component owl:Class
GO:0004349 biolink:NamedThing glutamate 5-kinase activity Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+). got7fsn_ti ATP-L-glutamate 5-phosphotransferase activity|ATP:L-glutamate 5-phosphotransferase activity|gamma-glutamate kinase activity|glutamate kinase activity|gamma-glutamyl kinase activity|ATP:gamma-L-glutamate phosphotransferase activity KEGG_REACTION:R00239|RHEA:14877|MetaCyc:GLUTKIN-RXN|EC:2.7.2.11 molecular_function owl:Class
GO:0009728 biolink:NamedThing detection of gibberellic acid stimulus The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of gibberellic acid stimulus biological_process owl:Class
GO:0005047 biolink:NamedThing signal recognition particle binding Binding to a signal recognition particle. got7fsn_ti signal recognition particle receptor|docking protein See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'. molecular_function owl:Class
GO:0043021 biolink:NamedThing ribonucleoprotein complex binding Binding to a complex of RNA and protein. got7fsn_ti ribonucleoprotein binding|RNP binding|protein-RNA complex binding molecular_function owl:Class
GO:0007617 biolink:NamedThing mating behavior The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. got7fsn_ti mating behaviour Wikipedia:Mating_behaviour biological_process owl:Class
GO:0019098 biolink:NamedThing reproductive behavior The specific behavior of an organism that is associated with reproduction. got7fsn_ti multi-organism reproductive behavior|reproductive behaviour|reproductive behavior in a multicellular organism|single-organism reproductive behavior|multicellular organism reproductive behavior jl 2012-09-19T16:01:37Z GO:0044704|GO:0033057|GO:0044705 biological_process owl:Class
GO:0000495 biolink:NamedThing box H/ACA RNA 3'-end processing Any process involved in forming the mature 3' end of a box H/ACA RNA molecule. got7fsn_ti box H/ACA RNA 3' end processing|box H/ACA snoRNA 3'-end processing|box H/ACA sRNA 3'-end processing https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0034964 biolink:NamedThing box H/ACA RNA processing Any process involved in the conversion of a primary box H/ACA type small RNA transcript into a mature box H/ACA RNA. got7fsn_ti box H/ACA sRNA processing|box H/ACA snoRNA processing https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:2000995 biolink:NamedThing negative regulation of mannan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process. got7fsn_ti negative regulation of mannan breakdown|negative regulation of mannan catabolism|negative regulation of mannan degradation tt 2011-08-08T03:19:11Z biological_process owl:Class
GO:2000925 biolink:NamedThing negative regulation of cellodextrin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellodextrin metabolic process. got7fsn_ti negative regulation of cellodextrin metabolism tt 2011-08-01T12:39:56Z biological_process owl:Class
GO:0009029 biolink:NamedThing tetraacyldisaccharide 4'-kinase activity Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a). got7fsn_ti lipid-A 4'-kinase activity|ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity RHEA:20700|KEGG_REACTION:R04657|MetaCyc:TETRAACYLDISACC4KIN-RXN|EC:2.7.1.130 molecular_function owl:Class
GO:0072479 biolink:NamedThing response to mitotic cell cycle spindle assembly checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle spindle assembly checkpoint signaling. got7fsn_ti response to Dma1-dependent checkpoint signalling|mitotic cell cycle spindle assembly checkpoint effector process|response to Dma1-dependent checkpoint signaling|response to signal involved in mitotic cell cycle spindle assembly checkpoint mah 2010-12-09T12:11:31Z GO:0044811 biological_process owl:Class
GO:0072485 biolink:NamedThing response to spindle assembly checkpoint signaling A process that occurs in response to signals generated as a result of spindle assembly checkpoint signaling. got7fsn_ti spindle assembly checkpoint effector process|response to signal involved in spindle assembly checkpoint mah 2010-12-09T12:19:35Z biological_process owl:Class
GO:1905773 biolink:NamedThing 8-hydroxy-2'-deoxyguanosine DNA binding Binding to 8-hydroxy-2'-deoxyguanosine an oxidized purine residue found in damaged DNA. got7fsn_ti nc 2016-12-21T15:57:27Z molecular_function owl:Class
GO:0106275 biolink:NamedThing NADP+-protein-arginine ADP-ribosyltransferase activity Catalysis of the reaction: NADP+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine. got7fsn_ti hjd 2020-07-02T01:39:04Z RHEA:54884|EC:2.4.2.31 molecular_function owl:Class
GO:0003956 biolink:NamedThing NAD(P)+-protein-arginine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine. got7fsn_ti NAD(P)+-arginine ADP-ribosyltransferase activity|NAD(P)-arginine ADP-ribosyltransferase activity|mono(ADP-ribosyl)transferase activity|mono(ADPribosyl)transferase activity|NAD+:L-arginine ADP-D-ribosyltransferase activity|NAD(P)+:L-arginine ADP-D-ribosyltransferase activity|protein-arginine ADP-ribosyltransferase activity|NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity|NAD(P)(+)--arginine ADP-ribosyltransferase activity|ADP-ribosyltransferase activity|peptidyl-arginine ADP-ribosylation activity|NAD(+):L-arginine ADP-D-ribosyltransferase activity MetaCyc:2.4.2.31-RXN|Reactome:R-HSA-1972385|EC:2.4.2.31 molecular_function owl:Class
GO:0046526 biolink:NamedThing D-xylulose reductase activity Catalysis of the reaction: NAD(+) + xylitol = D-xylulose + H(+) + NADH. got7fsn_ti xylitol dehydrogenase activity RHEA:20433|KEGG_REACTION:R01896|EC:1.1.1.9|MetaCyc:D-XYLULOSE-REDUCTASE-RXN|Reactome:R-HSA-5662471 molecular_function owl:Class
GO:0021818 biolink:NamedThing modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. got7fsn_ti modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:0047705 biolink:NamedThing bilirubin oxidase activity Catalysis of the reaction: 2 bilirubin + O(2) = 2 biliverdin + 2 H(2)O. got7fsn_ti bilirubin:oxygen oxidoreductase activity|bilirubin oxidase M-1 KEGG_REACTION:R02394|RHEA:20980|MetaCyc:BILIRUBIN-OXIDASE-RXN|EC:1.3.3.5 molecular_function owl:Class
GO:0016634 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. got7fsn_ti EC:1.3.3.- molecular_function owl:Class
GO:0048884 biolink:NamedThing neuromast development The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals. got7fsn_ti biological_process owl:Class
GO:0060275 biolink:NamedThing maintenance of stationary phase in response to starvation The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment. got7fsn_ti biological_process owl:Class
GO:0047155 biolink:NamedThing 3-hydroxymethylcephem carbamoyltransferase activity Catalysis of the reaction: a 3-hydroxymethylceph-3-em-4-carboxylate + carbamoyl-phosphate = phosphate + a 3-carbamoyloxymethylcephem. got7fsn_ti carbamoyl-phosphate:3-hydroxymethylceph-3-em-4-carboxylate carbamoyltransferase activity|3'-hydroxymethylcephem-O-carbamoyltransferase activity GO:0045447 MetaCyc:2.1.3.7-RXN|EC:2.1.3.7 molecular_function owl:Class
GO:0016743 biolink:NamedThing carboxyl- or carbamoyltransferase activity Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). got7fsn_ti carboxyl- and carbamoyltransferase activity EC:2.1.3.- molecular_function owl:Class
GO:0016201 biolink:NamedThing synaptic target inhibition The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source. got7fsn_ti biological_process owl:Class
GO:0004311 biolink:NamedThing farnesyltranstransferase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. got7fsn_ti geranylgeranyl pyrophosphate synthase activity|geranylgeranyl-diphosphate synthase activity|geranylgeranyl pyrophosphate synthetase activity|farnesyltransferase activity|trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity|geranylgeranyl-PP synthetase activity The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. KEGG_REACTION:R02061|RHEA:17653|MetaCyc:FARNESYLTRANSTRANSFERASE-RXN|EC:2.5.1.29 molecular_function owl:Class
GO:0043586 biolink:NamedThing tongue development The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. got7fsn_ti lingua development|glossa development biological_process owl:Class
GO:1990190 biolink:NamedThing peptide-glutamate-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide. got7fsn_ti tb 2013-09-11T20:21:25Z molecular_function owl:Class
GO:0021934 biolink:NamedThing hindbrain tangential cell migration The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration. got7fsn_ti hindbrain neurophilic migration biological_process owl:Class
GO:0021535 biolink:NamedThing cell migration in hindbrain The orderly movement of a cell that will reside in the hindbrain. got7fsn_ti biological_process owl:Class
GO:0044816 biolink:NamedThing Nsk1-Dlc1 complex A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation. got7fsn_ti jl 2013-10-21T14:38:16Z cellular_component owl:Class
GO:0052074 biolink:NamedThing positive regulation by symbiont of host salicylic acid-mediated defense response Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti induction by organism of host salicylic acid-mediated defense response|up regulation by symbiont of host salicylic acid-mediated defense response|stimulation by symbiont of host salicylic acid-mediated defense response|positive regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction|induction by organism of host SA-mediated defense response|up-regulation by symbiont of host salicylic acid-mediated defense response|upregulation by symbiont of host salicylic acid-mediated defense response|positive regulation by organism of host SA-mediated defense response|activation by symbiont of host salicylic acid-mediated defense response GO:0052272 biological_process owl:Class
GO:0085026 biolink:NamedThing tubovesicular membrane network A complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains. got7fsn_ti TVM network|TVN jl 2010-07-09T03:55:41Z cellular_component owl:Class
GO:0070277 biolink:NamedThing iodide oxidation The chemical reactions and pathways by which iodide is converted to diiodine, with the concomitant loss of electrons. got7fsn_ti biological_process owl:Class
GO:0070276 biolink:NamedThing halogen metabolic process The chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds. got7fsn_ti halogen metabolism biological_process owl:Class
GO:0047244 biolink:NamedThing N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-N-acetyl-D-mannosamine = N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP. got7fsn_ti N-acetylmannosaminyltransferase activity|uridine diphosphoacetyl-mannosamineacetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminyltransferase activity|UDP-N-acetyl-D-mannosamine:N-acetyl-beta-D-glucosaminyldiphosphoundecaprenol beta-1,4-N-acetylmannosaminyltransferase activity|UDP-N-acetylmannosamine:N-acetylglucosaminyl diphosphorylundecaprenol N-acetylmannosaminyltransferase activity EC:2.4.1.187|RHEA:16053|MetaCyc:TEICHOICSYN2-RXN molecular_function owl:Class
GO:0072028 biolink:NamedThing nephron morphogenesis The process in which the anatomical structures of the nephron are generated and organized. A nephron is the functional unit of the kidney. got7fsn_ti mah 2010-01-25T02:45:52Z biological_process owl:Class
GO:0050041 biolink:NamedThing lactate aldolase activity Catalysis of the reaction: (S)-lactate = acetaldehyde + formate. got7fsn_ti (S)-lactate acetaldehyde-lyase activity|(S)-lactate acetaldehyde-lyase (formate-forming)|lactate synthase activity EC:4.1.2.36|RHEA:17909|MetaCyc:LACTATE-ALDOLASE-RXN|KEGG_REACTION:R00753 molecular_function owl:Class
GO:0008302 biolink:NamedThing female germline ring canal formation, actin assembly Recruitment and organization of actin filaments in female germline ring canals. got7fsn_ti ring canal formation, actin assembly|nurse cell ring canal formation, actin assembly|ovarian ring canal formation, actin assembly biological_process owl:Class
GO:0004847 biolink:NamedThing urea carboxylase activity Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate. got7fsn_ti urea carboxylase (hydrolyzing) activity|urease (ATP-hydrolysing)|urea amidolyase activity|UALase activity|urea carboxylase (hydrolysing)|urea:carbon-dioxide ligase (ADP-forming)|urease (ATP-hydrolyzing) activity|UCA activity|ATP--urea amidolyase activity KEGG_REACTION:R00774|EC:6.3.4.6|RHEA:20896|MetaCyc:UREA-CARBOXYLASE-RXN molecular_function owl:Class
GO:0061304 biolink:NamedThing retinal blood vessel morphogenesis The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure. got7fsn_ti dph 2010-09-16T09:02:59Z biological_process owl:Class
GO:0070765 biolink:NamedThing gamma-secretase complex A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein. got7fsn_ti CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)|gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)|gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)|gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)|presenilin complex|PS2 complex|PS1 complex|gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) https://github.com/geneontology/go-ontology/issues/20317 mah 2009-06-29T01:33:19Z cellular_component owl:Class
GO:1990705 biolink:NamedThing cholangiocyte proliferation The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. got7fsn_ti hepatoblast proliferation 2015-03-16T23:23:50Z biological_process owl:Class
GO:0050673 biolink:NamedThing epithelial cell proliferation The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances. got7fsn_ti biological_process owl:Class
GO:0014046 biolink:NamedThing dopamine secretion The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone. got7fsn_ti biological_process owl:Class
GO:0018447 biolink:NamedThing chloral hydrate dehydrogenase activity Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol. got7fsn_ti UM-BBD_enzymeID:e0229 molecular_function owl:Class
GO:0047643 biolink:NamedThing alginate synthase activity Catalysis of the reaction: GDP-D-mannuronate + alginate(n) = GDP + alginate(n+1). got7fsn_ti mannuronosyl transferase activity|GDP-D-mannuronate:alginate D-mannuronyltransferase activity EC:2.4.1.33|MetaCyc:ALGINATE-SYNTHASE-RXN|RHEA:46876 molecular_function owl:Class
GO:0043502 biolink:NamedThing regulation of muscle adaptation Any process that modulates the frequency, rate or extent of muscle adaptation. got7fsn_ti regulation of muscle plasticity biological_process owl:Class
GO:0061129 biolink:NamedThing negative regulation of positive chemotaxis to cAMP by DIF-2 Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. got7fsn_ti dph 2010-05-17T08:50:33Z biological_process owl:Class
GO:0061125 biolink:NamedThing negative regulation of positive chemotaxis to cAMP by chlorinated alkylphenone Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. got7fsn_ti dph 2010-05-17T08:36:55Z biological_process owl:Class
GO:0052735 biolink:NamedThing tRNA (cytosine-3-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine. got7fsn_ti S-adenosyl-L-methionine:tRNA cytosine-3-methyltransferase activity|transfer ribonucleate cytosine 3-methyltransferase activity|tRNA cytosine 3-methyltransferase activity|S-adenosyl-L-methionine:tRNA (cytosine-3-)-methyltransferase activity|tRNA (cytosine 3)-methyltransferase activity|tRNA cytosine-3-methyltransferase activity molecular_function owl:Class
GO:0016427 biolink:NamedThing tRNA (cytosine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine. got7fsn_ti molecular_function owl:Class
GO:0004318 biolink:NamedThing enoyl-[acyl-carrier-protein] reductase (NADH) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. got7fsn_ti enoyl-[acyl-carrier protein] reductase (NADH) activity|NADH-enoyl acyl carrier protein reductase activity|acyl-acyl-carrier-protein:NAD+ oxidoreductase|NADH-specific enoyl-ACP reductase activity|enoyl-ACP reductase (NADH) activity|enoyl-acyl-carrier-protein reductase (NADH) MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN|EC:1.3.1.9 molecular_function owl:Class
GO:0031286 biolink:NamedThing negative regulation of sorocarp stalk cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum. got7fsn_ti down regulation of stalk cell differentiation|downregulation of stalk cell differentiation|down-regulation of stalk cell differentiation|negative regulation of stalk cell differentiation|inhibition of stalk cell differentiation biological_process owl:Class
GO:0075262 biolink:NamedThing negative regulation of spore-bearing organ development Any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores. got7fsn_ti biological_process owl:Class
GO:0048555 biolink:NamedThing generative cell nucleus The nucleus of the generative cell, a cell contained within the pollen grain that will divide to produce two haploid sperm cells. got7fsn_ti sperm cell nucleus|male germ cell nucleus cellular_component owl:Class
GO:0050279 biolink:NamedThing sepiapterin deaminase activity Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3. got7fsn_ti sepiapterin aminohydrolase activity RHEA:14025|EC:3.5.4.24|MetaCyc:SEPIAPTERIN-DEAMINASE-RXN molecular_function owl:Class
GO:0004467 biolink:NamedThing long-chain fatty acid-CoA ligase activity Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. got7fsn_ti long-chain fatty acid activation|long-chain acyl-coenzyme A synthetase activity|acyl-CoA synthetase activity|thiokinase|long-chain-fatty-acid-CoA ligase activity|acyl-activating enzyme activity|LCFA synthetase activity|pristanoyl-CoA synthetase|long-chain fatty acyl coenzyme A synthetase activity|acyl-CoA ligase activity|long-chain acyl CoA synthetase activity|long chain fatty acyl-CoA synthetase activity|long-chain-fatty-acyl-CoA synthetase activity|stearoyl-CoA synthetase|long-chain acyl-CoA synthetase activity|fatty acid thiokinase (long-chain) activity|lignoceroyl-CoA synthase activity https://github.com/geneontology/go-ontology/issues/20462|https://github.com/geneontology/go-ontology/issues/18967 GO:0003996 RHEA:15421|Reactome:R-HSA-193711|Reactome:R-HSA-192137|Reactome:R-HSA-5696004|Reactome:R-HSA-2046085|Reactome:R-HSA-2046098|MetaCyc:PWY-5143|Reactome:R-HSA-201035|Reactome:R-HSA-193743|Reactome:R-HSA-193766|Reactome:R-HSA-548843|MetaCyc:ACYLCOASYN-RXN|Reactome:R-HSA-193727|Reactome:R-HSA-159425|EC:6.2.1.3|Reactome:R-HSA-193407|Reactome:R-HSA-193424|UM-BBD_enzymeID:e0025|Reactome:R-HSA-193401 molecular_function owl:Class
GO:0015645 biolink:NamedThing fatty acid ligase activity Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP. got7fsn_ti fatty acid CoA ligase activity|fatty acyl-coenzyme A synthetase activity|fatty-acid ligase activity molecular_function owl:Class
GO:0007228 biolink:NamedThing positive regulation of hh target transcription factor activity Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited. got7fsn_ti activation of hh target transcription factor|positive regulation of hedgehog target transcription factor biological_process owl:Class
GO:0140429 biolink:NamedThing positive regulation of mitotic sister chromatid biorientation Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid biorientation, the mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. got7fsn_ti repair of mitotic merotelic kinetochore attachment defects|correction of merotelic kinetochore attachment, mitotic|correction of syntelic kinetochore attachment, mitotic|repair of mitotic merotelic kinetochore attachment defect|repair of mitotic mono-orientation defect|correction of mono-orientation defects|repair of mitotic mono-orientation defects https://github.com/geneontology/go-ontology/issues/18815 jl 2015-01-05T16:54:39Z GO:1990598|GO:0098783 biological_process owl:Class
GO:0140273 biolink:NamedThing repair of mitotic kinetochore microtubule attachment defect The mitotic cell cycle process where kinetochore microtubule attachment defects are corrected. got7fsn_ti correction of mitotic kinetochore microtubule attachment defects|repair of mitotic kinetochore microtubule attachment defects pg 2018-10-01T11:29:24Z biological_process owl:Class
GO:0052003 biolink:NamedThing suppression by symbiont of defense-related host salicylic acid-mediated signal transduction pathway Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation of host SA-mediated defense response|down-regulation by symbiont of host salicylic acid-mediated defense response|inhibition by symbiont of host salicylic acid-mediated defense response|suppression of host SA mediated defense response|negative regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|downregulation by symbiont of host salicylic acid-mediated defense response|down-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|down regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|negative modulation by organism of defense-related host SA-mediated signal transduction pathway|negative regulation by symbiont of host salicylic acid-mediated defense response|downregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|down regulation by symbiont of host salicylic acid-mediated defense response|negative regulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction|negative regulation by organism of defense-related salicylic acid-mediated signal transduction pathway of other organism involved in symbiotic interaction|negative modulation by organism of defense-related host salicylic acid-mediated signal transduction pathway|negative regulation by organism of defense-related host SA-mediated signal transduction pathway|suppression by organism of host salicylic acid-mediated defense response|inhibition by symbiont of defense-related host salicylic acid-mediated signal transduction pathway GO:0052004|GO:0052252|GO:0052253 biological_process owl:Class
GO:0019553 biolink:NamedThing glutamate catabolic process via L-citramalate The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate. got7fsn_ti glutamate breakdown via L-citramalate|glutamate degradation via L-citramalate MetaCyc:GLUDEG-II-PWY biological_process owl:Class
GO:0006538 biolink:NamedThing glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid. got7fsn_ti glutamate deamidation|glutamic acid catabolism|glutamic acid catabolic process|glutamate catabolism|glutamate degradation|glutamate breakdown GO:0019459 biological_process owl:Class
GO:0034008 biolink:NamedThing R-linalool synthase activity Catalysis of the reaction: geranyl diphosphate + H(2)O = (R)-linalool + diphosphate. got7fsn_ti (-)-3R-linalool synthase activity|(3R)-linalool synthase activity|geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming] activity KEGG_REACTION:R07632|MetaCyc:4.2.3.26-RXN|EC:4.2.3.26|RHEA:15809 molecular_function owl:Class
GO:0000497 biolink:NamedThing DNA template activity Binding to nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule. got7fsn_ti base pairing with DNA Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. molecular_function owl:Class
GO:0015778 biolink:NamedThing hexuronide transport The directed movement of hexuronide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate. got7fsn_ti biological_process owl:Class
GO:0008643 biolink:NamedThing carbohydrate transport The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. got7fsn_ti sugar transport GO:0008644|GO:0006861 biological_process owl:Class
GO:0036421 biolink:NamedThing extrinsic component of external side of mycolate outer membrane The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to external side of MOM|extrinsic to external side of mycolate outer membrane|extrinsic to external side of mycomembrane bf 2013-09-05T20:23:45Z cellular_component owl:Class
GO:0031242 biolink:NamedThing extrinsic component of external side of cell outer membrane The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to external side of cell outer membrane|extrinsic to external leaflet of cell outer membrane|extrinsic to external side of outer membrane cellular_component owl:Class
GO:0030851 biolink:NamedThing granulocyte differentiation The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils. got7fsn_ti granulocyte cell differentiation biological_process owl:Class
GO:0006370 biolink:NamedThing 7-methylguanosine mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. got7fsn_ti 5' mRNA capping|mRNA capping|5'-end mRNA processing|5'-end processing|5' end capping biological_process owl:Class
GO:0009452 biolink:NamedThing 7-methylguanosine RNA capping The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. got7fsn_ti m(7)G RNA capping|RNA capping biological_process owl:Class
GO:0061379 biolink:NamedThing inferior colliculus development The process whose specific outcome is the progression of the inferior colliculus over time, from its formation to the mature structure. The inferior colliculus (IC) (Latin, lower hill) is the principal midbrain nucleus of the auditory pathway and receives input from several more peripheral brainstem nuclei in the auditory pathway, as well as inputs from the auditory cortex. The inferior colliculus has three subdivisions: the central nucleus (CIC), a dorsal cortex (DCIC) by which it is surrounded, and an external cortex (ICX) which is located laterally. got7fsn_ti dph 2010-11-09T09:49:24Z biological_process owl:Class
GO:0001830 biolink:NamedThing trophectodermal cell fate commitment The cell fate commitment of precursor cells that will become trophectoderm cells. got7fsn_ti trophectoderm cell fate commitment See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. biological_process owl:Class
GO:0010289 biolink:NamedThing homogalacturonan biosynthetic process The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. got7fsn_ti MetaCyc:PWY-1061 biological_process owl:Class
GO:0052325 biolink:NamedThing cell wall pectin biosynthetic process The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall. got7fsn_ti cell wall pectin biosynthesis|pectin biosynthesis during cell wall organization and biogenesis biological_process owl:Class
GO:0018201 biolink:NamedThing peptidyl-glycine modification The modification of peptidyl-glycine. got7fsn_ti biological_process owl:Class
GO:0034985 biolink:NamedThing Ecsit-NDUFAF1 complex Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed. got7fsn_ti cellular_component owl:Class
GO:0045251 biolink:NamedThing electron transfer flavoprotein complex A protein complex facilitating the electron transfer from an acyl-CoA molecule to ubiquinone via its flavin adenine dinucleotide (FAD) cofactor. Usually contains an alpha and a beta subunit and the structural cofactor adenosine monophosphate (AMP). Part of a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the electron transport system. got7fsn_ti ETF complex cellular_component owl:Class
GO:0019203 biolink:NamedThing carbohydrate phosphatase activity Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. got7fsn_ti Reactome:R-HSA-3781011|Reactome:R-HSA-3791349|Reactome:R-HSA-3781018 molecular_function owl:Class
GO:0007259 biolink:NamedThing receptor signaling pathway via JAK-STAT Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. got7fsn_ti JAK-STAT cascade|JAK-STAT signal transduction Wikipedia:JAK-STAT_signaling_pathway biological_process owl:Class
GO:0097696 biolink:NamedThing receptor signaling pathway via STAT An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins. got7fsn_ti kinase activated-STAT cascade|kinase-STAT cascade|STAT signalling pathway In most species, STAT proteins are activated by members of the JAK (Janus Activated Kinase) family of tyrosine kinases; the term GO:0007259 'JAK-STAT cascade' describes this specificity. In other cases, such as D. discoideum, no JAK orthologs are known, and STAT proteins are activated by tyrosine kinase-like proteins. pr 2015-12-22T10:40:14Z biological_process owl:Class
GO:0046463 biolink:NamedThing acylglycerol biosynthetic process The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. got7fsn_ti acylglycerol formation|acylglycerol synthesis|acylglycerol anabolism|acylglycerol biosynthesis biological_process owl:Class
GO:0046460 biolink:NamedThing neutral lipid biosynthetic process The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity. got7fsn_ti neutral lipid formation|neutral lipid biosynthesis|neutral lipid anabolism|neutral lipid synthesis biological_process owl:Class
GO:0010026 biolink:NamedThing trichome differentiation The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana. got7fsn_ti trichome cell differentiation GO:0048271 biological_process owl:Class
GO:0040012 biolink:NamedThing regulation of locomotion Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. got7fsn_ti biological_process owl:Class
GO:0044842 biolink:NamedThing gut granule lumen The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. got7fsn_ti jl 2014-03-25T12:02:32Z cellular_component owl:Class
GO:0050433 biolink:NamedThing regulation of catecholamine secretion Any process that modulates the frequency, rate or extent of the regulated release of catecholamines. got7fsn_ti biological_process owl:Class
GO:0006089 biolink:NamedThing lactate metabolic process The chemical reactions and pathways involving lactate, the anion of lactic acid. got7fsn_ti 2-hydroxypropanoate metabolism|2-hydroxypropanoate metabolic process|alpha-hydroxypropionate metabolism|lactate metabolism|alpha-hydroxypropionate metabolic process biological_process owl:Class
GO:0006929 biolink:NamedThing substrate-dependent cell migration The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate. got7fsn_ti substrate-bound cell migration biological_process owl:Class
GO:0047768 biolink:NamedThing carboxy-cis,cis-muconate cyclase activity Catalysis of the reaction: 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate. got7fsn_ti 3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)|3-carboxymuconate cyclase activity|3-carboxy-cis,cis-muconate lactonizing enzyme activity MetaCyc:CARBOXY-CISCIS-MUCONATE-CYCLASE-RXN|RHEA:14977|EC:5.5.1.5|KEGG_REACTION:R03308 molecular_function owl:Class
GO:0009975 biolink:NamedThing cyclase activity Catalysis of a ring closure reaction. got7fsn_ti molecular_function owl:Class
GO:0071932 biolink:NamedThing replication fork reversal Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved. got7fsn_ti mah 2010-09-29T02:34:22Z biological_process owl:Class
GO:0102806 biolink:NamedThing 4-coumaroyl-CoA:cyanidin-3,5-diglucoside-6''-O-acyltransferase activity Catalysis of the reaction: 4-coumaryl-CoA + cyanin betaine <=> shisonin + coenzyme A. got7fsn_ti MetaCyc:RXN-8170 molecular_function owl:Class
GO:0031769 biolink:NamedThing glucagon receptor binding Binding to a glucagon receptor. got7fsn_ti glucagon receptor ligand molecular_function owl:Class
GO:0008923 biolink:NamedThing lysine decarboxylase activity Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2). got7fsn_ti L-lysine carboxy-lyase (cadaverine-forming)|L-lysine carboxy-lyase activity MetaCyc:LYSDECARBOX-RXN|EC:4.1.1.18|MetaCyc:PWY0-461|RHEA:22352|KEGG_REACTION:R00462 molecular_function owl:Class
GO:0035005 biolink:NamedThing 1-phosphatidylinositol-4-phosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). got7fsn_ti C2-domain-containing phosphoinositide 3-kinase activity|phosphatidylinositol 3-kinase activity, class II|phosphatidylinositol-4-phosphate 3-kinase activity|ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase activity|phosphatidylinositol 3-kinase activity, class I|phosphatidylinositol 3-kinase, class I, catalyst activity|type II phosphoinositide 3-kinase activity Reactome:R-HSA-1675928|Reactome:R-HSA-1676109|MetaCyc:2.7.1.154-RXN|Reactome:R-HSA-8868072|RHEA:18373|Reactome:R-HSA-1676206|EC:2.7.1.154|KEGG_REACTION:R05795 molecular_function owl:Class
GO:0035004 biolink:NamedThing phosphatidylinositol 3-kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. got7fsn_ti phosphoinositide 3-kinase activity Reactome:R-HSA-2045911|Reactome:R-HSA-9670433|Wikipedia:Phosphoinositide_3-kinase|Reactome:R-HSA-1433514|Reactome:R-HSA-9028519 molecular_function owl:Class
GO:0009289 biolink:NamedThing pilus A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. got7fsn_ti fimbria|fimbrium|fimbriae|pili Wikipedia:Pilus cellular_component owl:Class
GO:0042995 biolink:NamedThing cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon. got7fsn_ti cellular process|cellular projection|cell process cellular_component owl:Class
GO:0035042 biolink:NamedThing fertilization, exchange of chromosomal proteins Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity. got7fsn_ti sperm-specific histone replacement|sperm-specific histone exchange biological_process owl:Class
GO:0043486 biolink:NamedThing histone exchange The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits. got7fsn_ti histone replacement|histone chaperone Note that this term also includes the exchange of sperm-specific histones or protamines with histones, occurring during spermatogenesis and fertilization. biological_process owl:Class
GO:0071200 biolink:NamedThing Kv4.2-DPP6 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.2. got7fsn_ti Kv4.2-DPPX channel complex mah 2009-11-23T05:18:31Z CORUM:603 cellular_component owl:Class
GO:0004741 biolink:NamedThing [pyruvate dehydrogenase (lipoamide)] phosphatase activity Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate. got7fsn_ti pyruvate dehydrogenase (lipoamide)-phosphatase activity|pyruvate dehydrogenase (lipoamide) phosphatase activity|phosphopyruvate dehydrogenase phosphatase activity|pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity|[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity|pyruvate dehydrogenase phosphatase activity GO:0019906 Reactome:R-HSA-204169|RHEA:12669|MetaCyc:3.1.3.43-RXN|EC:3.1.3.43 molecular_function owl:Class
GO:0071206 biolink:NamedThing establishment of protein localization to juxtaparanode region of axon The directed movement of a protein to the juxtaparanode region of an axon. got7fsn_ti establishment of protein localisation to juxtaparanode region of axon mah 2009-11-25T01:15:23Z biological_process owl:Class
GO:0047538 biolink:NamedThing 2-carboxy-D-arabinitol-1-phosphatase activity Catalysis of the reaction: 2-carboxy-D-arabinitol 1-phosphate + H(2)O = 2-carboxy-D-arabinitol + phosphate. got7fsn_ti 2-carboxyarabinitol 1-phosphatase activity|2-carboxy-D-arabinitol-1-phosphate 1-phosphohydrolase activity|2-carboxy-D-arabinitol 1-phosphate phosphohydrolase activity RHEA:17837|KEGG_REACTION:R04167|EC:3.1.3.63|MetaCyc:2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RXN molecular_function owl:Class
GO:0060113 biolink:NamedThing inner ear receptor cell differentiation The process in which relatively unspecialized cells, acquire specialized structural and/or functional features of inner ear receptor cells. Inner ear receptor cells are mechanorecptors found in the inner ear responsible for transducing signals involved in balance and sensory perception of sound. got7fsn_ti inner ear hair cell differentiation biological_process owl:Class
GO:0042490 biolink:NamedThing mechanoreceptor differentiation The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. got7fsn_ti biological_process owl:Class
GO:0034681 biolink:NamedThing integrin alpha11-beta1 complex An integrin complex that comprises one alpha11 subunit and one beta1 subunit. got7fsn_ti ITGA11-ITGB1 complex|alpha11-beta1 integrin complex cellular_component owl:Class
GO:0099008 biolink:NamedThing viral entry via permeabilization of inner membrane The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane. got7fsn_ti viral penetration via permeabilization of host membrane VZ:985 biological_process owl:Class
GO:0140267 biolink:NamedThing viral entry via permeabilization of host membrane The entry of a virus into the cytoplasm of a host cell, triggered by an interaction between the bilayer of a host membrane and a membrane-penetration capsid protein. Results in release of the virus contents into the host cell cytoplasm. got7fsn_ti pg 2018-09-25T14:33:03Z biological_process owl:Class
GO:0050048 biolink:NamedThing L-leucine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate. got7fsn_ti leucine-alpha-ketoglutarate transaminase activity|leucine 2-oxoglutarate transaminase activity|leucine aminotransferase activity|leucine transaminase activity|L-leucine aminotransferase activity EC:2.6.1.6|RHEA:18321|MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:0051480 biolink:NamedThing regulation of cytosolic calcium ion concentration Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings. got7fsn_ti regulation of calcium ion concentration in cytoplasm|regulation of cytosolic calcium ion concentration|calcium ion homeostasis in cytoplasm|cytoplasmic calcium ion homeostasis|cytosolic calcium ion concentration regulation|regulation of calcium ion concentration in cytosol|cytoplasmic calcium ion concentration regulation|calcium ion homeostasis in cytosol|regulation of cytoplasmic calcium ion concentration biological_process owl:Class
GO:0031851 biolink:NamedThing kappa-type opioid receptor binding Binding to a kappa-type opioid receptor. got7fsn_ti dynorphin receptor binding|kappa-type opioid receptor ligand molecular_function owl:Class
GO:0018303 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide RESID:AA0285 biological_process owl:Class
GO:0051173 biolink:NamedThing positive regulation of nitrogen compound metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. got7fsn_ti positive regulation of nitrogen metabolic process|activation of nitrogen metabolic process|up regulation of nitrogen metabolic process|upregulation of nitrogen metabolic process|up-regulation of nitrogen metabolic process|stimulation of nitrogen metabolic process|positive regulation of nitrogen metabolism biological_process owl:Class
GO:0001846 biolink:NamedThing opsonin binding Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. got7fsn_ti Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. molecular_function owl:Class
GO:0051551 biolink:NamedThing aurone biosynthetic process The chemical reactions and pathways resulting in the formation of aurones, a series of yellow plant pigments. got7fsn_ti benzalcoumaran-3-one biosynthetic process|benzalcoumaran-3-one biosynthesis biological_process owl:Class
GO:0009813 biolink:NamedThing flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. got7fsn_ti flavonoid formation|flavonoid biosynthesis|flavonoid anabolism|flavonoid synthesis Wikipedia:Flavonoid|MetaCyc:PWY1F-FLAVSYN biological_process owl:Class
GO:0051992 biolink:NamedThing UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine + di-trans,poly-cis-undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol. got7fsn_ti Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. ai 2010-07-06T12:10:01Z MetaCyc:PHOSNACMURPENTATRANS-RXN|RHEA:28386|EC:2.7.8.13 molecular_function owl:Class
GO:0019072 biolink:NamedThing viral genome packaging The encapsulation of the viral genome within the capsid. got7fsn_ti biological_process owl:Class
GO:0008418 biolink:NamedThing protein-N-terminal asparagine amidohydrolase activity Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein. got7fsn_ti molecular_function owl:Class
GO:0045475 biolink:NamedThing locomotor rhythm The rhythm of the locomotor activity of an organism during its 24 hour activity cycle. got7fsn_ti circadian locomotor activity rhythm biological_process owl:Class
GO:0046703 biolink:NamedThing natural killer cell lectin-like receptor binding Binding to a lectin-like natural killer cell receptor. got7fsn_ti KLRC4 receptor binding|NKG2D receptor binding|NK cell lectin-like receptor binding molecular_function owl:Class
GO:0050287 biolink:NamedThing sorbose 5-dehydrogenase (NADP+) activity Catalysis of the reaction: L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH. got7fsn_ti reduced nicotinamide adenine dinucleotide phosphate-linked reductase activity|sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|5-keto-D-fructose reductase activity|5-ketofructose reductase activity|L-sorbose:NADP+ 5-oxidoreductase activity EC:1.1.1.123|RHEA:15001|KEGG_REACTION:R01694|MetaCyc:SORBOSE-5-DEHYDROGENASE-NADP+-RXN molecular_function owl:Class
GO:0072134 biolink:NamedThing nephrogenic mesenchyme morphogenesis The process in which the anatomical structures of a nephrogenic mesenchymal tissue are generated and organized. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron. got7fsn_ti mah 2010-02-22T02:21:16Z biological_process owl:Class
GO:0140301 biolink:NamedThing pollen-stigma interaction The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae. got7fsn_ti pg 2019-02-22T13:58:21Z biological_process owl:Class
GO:0009875 biolink:NamedThing pollen-pistil interaction The interaction between a pollen grain and pistil. got7fsn_ti pollen-gynoecium interaction biological_process owl:Class
GO:0060519 biolink:NamedThing cell adhesion involved in prostatic bud elongation The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the elongation of the primary prostatic bud. got7fsn_ti biological_process owl:Class
GO:0007155 biolink:NamedThing cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. got7fsn_ti single organism cell adhesion|cell adhesion molecule activity dos 2014-04-15T15:59:10Z GO:0098602 Wikipedia:Cell_adhesion biological_process owl:Class
GO:0062180 biolink:NamedThing 25-hydroxycholecalciferol-23-hydroxylase activity Catalysis of the reaction: calcidiol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized [adrenodoxin]. got7fsn_ti dph 2019-11-26T17:12:22Z RHEA:46616 molecular_function owl:Class
GO:0062179 biolink:NamedThing vitamin D 23-hydroxylase activity Catalysis of the hydroxylation of C-23 of any form of vitamin D. got7fsn_ti dph 2019-11-26T17:10:29Z molecular_function owl:Class
GO:0031123 biolink:NamedThing RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. got7fsn_ti RNA 3' end processing biological_process owl:Class
GO:0047376 biolink:NamedThing all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity Catalysis of the reaction: all-trans-retinyl palmitate + H2O = all-trans-retinol + H+ + palmitate. got7fsn_ti retinyl-palmitate palmitohydrolase activity|all-trans-retinyl-palmitate acylhydrolase activity|all-trans-retinyl-palmitate hydrolase activity Reactome:R-HSA-2404140|KEGG_REACTION:R02368|MetaCyc:3.1.1.64-RXN|RHEA:13933|Reactome:R-HSA-2429643 molecular_function owl:Class
GO:0042724 biolink:NamedThing thiamine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds. got7fsn_ti thiamin and derivative biosynthesis|vitamin B1 and derivative biosynthesis|thiamine and derivative biosynthesis|thiamine-containing compound anabolism|vitamin B1 and derivative biosynthetic process|thiamine-containing compound synthesis|thiamin-containing compound biosynthetic process|thiamine-containing compound formation|thiamin and derivative biosynthetic process|thiamine-containing compound biosynthesis|thiamine and derivative biosynthetic process biological_process owl:Class
GO:0047235 biolink:NamedThing sucrose 6F-alpha-galactotransferase activity Catalysis of the reaction: sucrose + UDP-galactose = 6F-alpha-D-galactosylsucrose + UDP. got7fsn_ti UDPgalactose:sucrose 6F-alpha-D-galactosyltransferase activity|UDP-galactose:sucrose 6F-alpha-D-galactosyltransferase activity|uridine diphosphogalactose-sucrose 6F-alpha-galactosyltransferase activity|UDPgalactose:sucrose 6fru-alpha-galactosyltransferase activity|sucrose 6(F)-alpha-galactosyltransferase activity|sucrose 6F-alpha-galactosyltransferase activity MetaCyc:2.4.1.167-RXN|EC:2.4.1.167|RHEA:10088 molecular_function owl:Class
GO:0031003 biolink:NamedThing actin tubule A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together. got7fsn_ti cellular_component owl:Class
GO:0032432 biolink:NamedThing actin filament bundle An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness. got7fsn_ti actin cable GO:0030482|GO:0000141 cellular_component owl:Class
GO:0033726 biolink:NamedThing aldehyde ferredoxin oxidoreductase activity Catalysis of the reaction: an aldehyde + H2O + 2 oxidized ferredoxin = an acid + 2 H+ + 2 reduced ferredoxin. got7fsn_ti tungsten-containing aldehyde ferredoxin oxidoreductase activity|aldehyde:ferredoxin oxidoreductase activity|AOR EC:1.2.7.5|MetaCyc:1.2.7.5-RXN|RHEA:16421 molecular_function owl:Class
GO:0016625 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. got7fsn_ti oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor EC:1.2.7.- molecular_function owl:Class
GO:0061817 biolink:NamedThing endoplasmic reticulum-plasma membrane tethering The attachment of an endoplasmic reticulum membrane to the plasma membrane via molecular tethers. got7fsn_ti ER-plasma membrane tethering dph 2016-12-05T14:43:58Z biological_process owl:Class
GO:0022810 biolink:NamedThing membrane potential driven uniporter activity Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. got7fsn_ti porter molecular_function owl:Class
GO:0070469 biolink:NamedThing respirasome The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. got7fsn_ti respiratory chain|membrane electron transport chain https://github.com/geneontology/go-ontology/issues/12846 cellular_component owl:Class
GO:0072076 biolink:NamedThing nephrogenic mesenchyme development The biological process whose specific outcome is the progression of a nephrogenic mesenchyme from an initial condition to its mature state. This process begins with the formation of nephrogenic mesenchyme and ends with the mature structure. Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron. got7fsn_ti mah 2010-01-25T04:40:44Z biological_process owl:Class
GO:0072074 biolink:NamedThing kidney mesenchyme development The biological process whose specific outcome is the progression of a kidney mesenchyme from an initial condition to its mature state. This process begins with the formation of kidney mesenchyme and ends with the mature structure. Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney. got7fsn_ti mah 2010-01-25T04:39:04Z biological_process owl:Class
GO:0098857 biolink:NamedThing membrane microdomain A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. got7fsn_ti cellular_component owl:Class
GO:0070121 biolink:NamedThing Kupffer's vesicle development The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period. got7fsn_ti KV development biological_process owl:Class
GO:0004333 biolink:NamedThing fumarate hydratase activity Catalysis of the reaction: (S)-malate = fumarate + H(2)O. got7fsn_ti (S)-malate hydro-lyase activity|fumarase activity|L-malate hydro-lyase activity|(S)-malate hydro-lyase (fumarate-forming) Reactome:R-HSA-451033|MetaCyc:FUMHYDR-RXN|RHEA:12460|Reactome:R-HSA-70982|EC:4.2.1.2|KEGG_REACTION:R01082 molecular_function owl:Class
GO:0071050 biolink:NamedThing sno(s)RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of snoRNA class molecule (referred to as an sRNA in Archaea). In eukaryotes, this occurs in conjunction with termination of transcription of precursor snoRNA molecules and may occur post-transcriptionally on incorrectly processed molecules targeted for degradation. got7fsn_ti sRNA polyadenylation|snoRNA polyadenylation https://github.com/geneontology/go-ontology/issues/20416 krc 2009-08-25T03:33:44Z biological_process owl:Class
GO:0140069 biolink:NamedThing histone butyryltransferase activity Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone. got7fsn_ti pg 2017-07-20T16:56:33Z molecular_function owl:Class
GO:0008297 biolink:NamedThing single-stranded DNA exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. got7fsn_ti ssDNA-specific exodeoxyribonuclease activity|single-stranded DNA specific exodeoxyribonuclease activity molecular_function owl:Class
GO:0010407 biolink:NamedThing non-classical arabinogalactan protein metabolic process The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains. got7fsn_ti non-classical arabinogalactan protein metabolism biological_process owl:Class
GO:0010405 biolink:NamedThing arabinogalactan protein metabolic process The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures. got7fsn_ti arabinogalactan protein metabolism biological_process owl:Class
GO:0030785 biolink:NamedThing [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine. got7fsn_ti S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity|RuBisCO methyltransferase activity|RuBisCO LSMT activity|ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity|ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity|ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity|S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity MetaCyc:2.1.1.127-RXN|EC:2.1.1.127|RHEA:50996 molecular_function owl:Class
GO:0005850 biolink:NamedThing eukaryotic translation initiation factor 2 complex Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. got7fsn_ti eIF-2|eIF2 Wikipedia:EIF-2 cellular_component owl:Class
GO:0006417 biolink:NamedThing regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. got7fsn_ti regulation of protein biosynthesis|regulation of protein formation|regulation of protein anabolism|regulation of protein synthesis GO:0006445 biological_process owl:Class
GO:0010608 biolink:NamedThing posttranscriptional regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. got7fsn_ti biological_process owl:Class
GO:0031483 biolink:NamedThing myosin XIII complex A myosin complex containing one or more class XIII myosin heavy chains and associated light chains. got7fsn_ti cellular_component owl:Class
GO:0007486 biolink:NamedThing imaginal disc-derived female genitalia development The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster. got7fsn_ti female genital development biological_process owl:Class
GO:0033734 biolink:NamedThing (R)-benzylsuccinyl-CoA dehydrogenase activity Catalysis of the reaction: (R)-2-benzylsuccinyl-CoA + 2 electron-transferring flavoprotein = (E)-2-benzylidenesuccinyl-CoA + 2 reduced electron-transferring flavoprotein. got7fsn_ti BbsG|(R)-benzylsuccinyl-CoA:acceptor oxidoreductase activity|(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase activity RHEA:20876|EC:1.3.8.3|UM-BBD_reactionID:r0330 molecular_function owl:Class
GO:0046883 biolink:NamedThing regulation of hormone secretion Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell. got7fsn_ti biological_process owl:Class
GO:0009086 biolink:NamedThing methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. got7fsn_ti methionine formation|methionine synthesis|methionine anabolism|methionine biosynthesis biological_process owl:Class
GO:0009067 biolink:NamedThing aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. got7fsn_ti aspartate family amino acid anabolism|aspartate family amino acid biosynthesis|aspartate family amino acid synthesis|aspartate family amino acid formation biological_process owl:Class
GO:1901135 biolink:NamedThing carbohydrate derivative metabolic process The chemical reactions and pathways involving carbohydrate derivative. got7fsn_ti carbohydrate derivative metabolism bf 2012-07-12T04:05:09Z biological_process owl:Class
GO:0040038 biolink:NamedThing polar body extrusion after meiotic divisions The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes. got7fsn_ti biological_process owl:Class
GO:0033206 biolink:NamedThing meiotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells. got7fsn_ti cytokinesis after meiosis biological_process owl:Class
GO:0010582 biolink:NamedThing floral meristem determinacy The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate). got7fsn_ti biological_process owl:Class
GO:0010022 biolink:NamedThing meristem determinacy The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate). got7fsn_ti biological_process owl:Class
GO:0099127 biolink:NamedThing envenomation resulting in positive regulation of argininosuccinate synthase activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of the cytosolic argininosuccinate synthase in the bitten organism. got7fsn_ti biological_process owl:Class
GO:0080183 biolink:NamedThing response to photooxidative stress Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as the result of a photooxidative stress, the light-dependent generation of active oxygen species. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. got7fsn_ti dhl 2011-08-10T04:26:11Z biological_process owl:Class
GO:0003224 biolink:NamedThing left ventricular compact myocardium morphogenesis The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized. got7fsn_ti dph 2009-10-13T10:43:36Z biological_process owl:Class
GO:0003223 biolink:NamedThing ventricular compact myocardium morphogenesis The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized. got7fsn_ti dph 2009-10-13T10:34:21Z biological_process owl:Class
GO:0001069 biolink:NamedThing regulatory region RNA binding Binding to a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. got7fsn_ti krc 2010-10-21T04:17:01Z molecular_function owl:Class
GO:0060346 biolink:NamedThing bone trabecula formation The process of creating a trabecula in the bone. A trabecula is a tissue element in the form of a small beam, strut or rod. got7fsn_ti skeletal trabecula biogenesis|skeletal trabecula formation|bone trabeculation|skeletal trabeculation|bone trabecula biogenesis biological_process owl:Class
GO:0048236 biolink:NamedThing plant-type sporogenesis The formation of plant spores derived from the products of meiosis. The spore gives rise to gametophytes. got7fsn_ti plant spore formation biological_process owl:Class
GO:0051321 biolink:NamedThing meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. got7fsn_ti meiosis Note that this term should not be confused with 'GO:0140013 ; meiotic nuclear division'. 'GO:0051321 ; meiotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140013 meiotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle. GO:0007126 Wikipedia:Meiosis biological_process owl:Class
GO:0090122 biolink:NamedThing cholesterol ester hydrolysis involved in cholesterol transport The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport. got7fsn_ti tb 2009-12-07T01:06:54Z biological_process owl:Class
GO:0004767 biolink:NamedThing sphingomyelin phosphodiesterase activity Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+). got7fsn_ti sphingomyelinase activity|sphingomyelin cholinephosphohydrolase activity GO:0030231|GO:0030230 Reactome:R-HSA-1606273|RHEA:19253|MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN|Reactome:R-HSA-1606288|KEGG_REACTION:R02541|Reactome:R-HSA-1640164|Reactome:R-HSA-1605797|EC:3.1.4.12|Reactome:R-HSA-193706 molecular_function owl:Class
GO:0001098 biolink:NamedThing basal transcription machinery binding Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. got7fsn_ti Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. krc 2010-11-24T12:50:49Z molecular_function owl:Class
GO:0004362 biolink:NamedThing glutathione-disulfide reductase (NADPH) activity Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. got7fsn_ti GSSG reductase activity|GSH reductase activity|oxidized glutathione reduction|glutathione:NADP+ oxidoreductase activity|glutathione reductase activity|NADPH:oxidized-glutathione oxidoreductase activity|glutathione-disulfide reductase activity|NADPH-GSSG reductase activity|NADPH-glutathione reductase activity|glutathione-disulphide reductase activity|glutathione S-reductase activity glutathione-disulfide reductase activity Note that this function was formerly EC:1.6.4.2. Reactome:R-HSA-71682|RHEA:11740|MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN|Reactome:R-HSA-3323079|EC:1.8.1.7 molecular_function owl:Class
GO:0016209 biolink:NamedThing antioxidant activity Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. got7fsn_ti molecular_function owl:Class
GO:0009785 biolink:NamedThing blue light signaling pathway The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm. got7fsn_ti blue light signalling pathway biological_process owl:Class
GO:0071078 biolink:NamedThing fibronectin-tissue transglutaminase complex A protein complex that consists of fibronectin bound to tissue transglutaminase, and is involved in cell adhesion. got7fsn_ti FN-TGM2 complex mah 2009-11-06T04:42:22Z cellular_component owl:Class
GO:0102702 biolink:NamedThing 2-carene synthase activity Catalysis of the reaction: geranyl diphosphate <=> (+)-2-carene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-5122 molecular_function owl:Class
GO:1990646 biolink:NamedThing cellular response to prolactin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. got7fsn_ti sl 2015-02-18T16:53:11Z biological_process owl:Class
GO:1990637 biolink:NamedThing response to prolactin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation. got7fsn_ti sl 2015-02-10T23:47:11Z biological_process owl:Class
GO:0018401 biolink:NamedThing peptidyl-proline hydroxylation to 4-hydroxy-L-proline The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase. got7fsn_ti See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'. RESID:AA0030 biological_process owl:Class
GO:0033518 biolink:NamedThing myo-inositol hexakisphosphate dephosphorylation The process of removing one or more phosphate group from myo-inositol hexakisphosphate. got7fsn_ti phytate dephosphorylation MetaCyc:PWY-4781|MetaCyc:PWY-4702 biological_process owl:Class
GO:0046855 biolink:NamedThing inositol phosphate dephosphorylation The process of removing a phosphate group from any mono- or polyphosphorylated inositol. got7fsn_ti myo-inositol phosphate dephosphorylation biological_process owl:Class
GO:0102214 biolink:NamedThing omega-hydroxy fatty acyl-CoA synthetase activity Catalysis of the reaction: coenzyme A + ATP + an omega-hydroxy fatty acid = diphosphoric acid + AMP + a omega-hydroxyacyl-CoA. got7fsn_ti MetaCyc:RXN-12185 molecular_function owl:Class
GO:0018002 biolink:NamedThing N-terminal peptidyl-glutamic acid acetylation The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid. got7fsn_ti See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. RESID:AA0044 biological_process owl:Class
GO:1905604 biolink:NamedThing negative regulation of blood-brain barrier permeability Any process that decreases blood-brain barrier permeability, the quality of the blood-brain barrier that allows for a controlled passage of substances (e.g. macromolecules, small molecules, ions) into and out of the brain. got7fsn_ti downregulation of BBB permeability|down-regulation of blood/brain barrier permeability|downregulation of blood/brain barrier permeability|downregulation of blood-brain barrier permeability|down-regulation of blood-brain barrier permeability|inhibition of maintenance of permeability of blood-brain barrier|inhibition of maintenance of permeability of BBB|down-regulation of BBB permeability|negative regulation of blood/brain barrier permeability|negative regulation of BBB permeability als 2016-10-26T13:18:25Z biological_process owl:Class
GO:0070331 biolink:NamedThing CD20-Lck-Fyn complex A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck and Fyn. got7fsn_ti cellular_component owl:Class
GO:0005759 biolink:NamedThing mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. got7fsn_ti mitochondrial stroma|mitochondrial lumen GO:0031980 Wikipedia:Mitochondrial_matrix|NIF_Subcellular:sao1804523077 cellular_component owl:Class
GO:0046314 biolink:NamedThing phosphocreatine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase. got7fsn_ti phosphocreatine anabolism|phosphocreatine synthesis|phosphocreatine formation|phosphocreatine biosynthesis biological_process owl:Class
GO:0006603 biolink:NamedThing phosphocreatine metabolic process The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle. got7fsn_ti phosphocreatine metabolism biological_process owl:Class
GO:0003975 biolink:NamedThing UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol. got7fsn_ti chitobiosylpyrophosphoryldolichol synthase activity|UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity|uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity|UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity|UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity|UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity|UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity|N-acetylglucosamine-1-phosphate transferase activity|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity|UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity|GlcNAc-1-P transferase activity|dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity Reactome:R-HSA-446191|EC:2.7.8.15|RHEA:13289|MetaCyc:2.7.8.15-RXN|Reactome:R-HSA-4549334 molecular_function owl:Class
GO:0047622 biolink:NamedThing adenosine nucleosidase activity Catalysis of the reaction: adenosine + H2O = D-ribose + adenine. got7fsn_ti adenosine hydrolase activity|N-ribosyladenine ribohydrolase activity|adenosine ribohydrolase activity|adenosinase activity|ANase activity MetaCyc:ADENOSINE-NUCLEOSIDASE-RXN|RHEA:18669|EC:3.2.2.7 molecular_function owl:Class
GO:0008477 biolink:NamedThing purine nucleosidase activity Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose. got7fsn_ti N-ribosyl purine ribohydrolase activity|N-D-ribosylpurine ribohydrolase activity|purine nucleoside hydrolase activity|purine ribonucleosidase activity|purine beta-ribosidase activity|ribonucleoside hydrolase activity|IAG-NH activity|IAG-nucleoside hydrolase activity|purine-specific nucleoside N-ribohydrolase activity|nucleosidase activity|purine-nucleoside ribohydrolase activity|nucleoside hydrolase activity|nucleosidase g activity|purine nucleosidase reaction|inosine-adenosine-guanosine preferring nucleoside hydrolase activity RHEA:23344|MetaCyc:PURINE-NUCLEOSIDASE-RXN|EC:3.2.2.1 molecular_function owl:Class
GO:0061740 biolink:NamedThing protein targeting to lysosome involved in chaperone-mediated autophagy The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor. got7fsn_ti dph 2015-10-21T08:41:29Z biological_process owl:Class
GO:0006622 biolink:NamedThing protein targeting to lysosome The process of directing proteins towards the lysosome using signals contained within the protein. got7fsn_ti protein-lysosome targeting biological_process owl:Class
GO:0045435 biolink:NamedThing lycopene epsilon cyclase activity Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene). got7fsn_ti lycopene cyclase molecular_function owl:Class
GO:0033276 biolink:NamedThing transcription factor TFTC complex A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity. got7fsn_ti cellular_component owl:Class
GO:0070461 biolink:NamedThing SAGA-type complex A histone acetyltransferase complex that acetylates nucleosomal histones H2B, H3, or H4 and is required for the expression of a subset of Pol II-transcribed genes. This complex includes the acetyltransferases GCN5/KAT2A or PCAF/KAT2B, several proteins of the ADA, SGF and SPT families, and several TBP-associate proteins (TAFs). got7fsn_ti SAGA family complex cellular_component owl:Class
GO:0055117 biolink:NamedThing regulation of cardiac muscle contraction Any process that modulates the frequency, rate or extent of cardiac muscle contraction. got7fsn_ti biological_process owl:Class
GO:0006942 biolink:NamedThing regulation of striated muscle contraction Any process that modulates the frequency, rate or extent of striated muscle contraction. got7fsn_ti biological_process owl:Class
GO:0033881 biolink:NamedThing bile-acid-CoA hydrolase activity Catalysis of the reaction: deoxycholoyl-CoA + H(2)O = CoA + deoxycholate + H(+). got7fsn_ti bile acid-coenzyme A hydrolase activity|deoxycholoyl-CoA hydrolase activity KEGG_REACTION:R07295|RHEA:17693|EC:3.1.2.26|MetaCyc:BACOAHYDRO-RXN molecular_function owl:Class
GO:0031044 biolink:NamedThing O-glycan processing, core 8 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc. got7fsn_ti biological_process owl:Class
GO:0010622 biolink:NamedThing specification of ovule identity The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0005706 biolink:NamedThing polytene chromosome ectopic fiber A thread-like connection joining two regions of ectopically paired polytene chromosomes. got7fsn_ti polytene chromosome ectopic fibre cellular_component owl:Class
GO:0097601 biolink:NamedThing retina blood vessel maintenance A retina homeostatic process preventing the degeneration of a retina blood vessel. got7fsn_ti maintenance of retina blood vessel|maintenance of retinal blood vessel|maintenance of choriocapillaris pr 2014-05-11T18:42:24Z biological_process owl:Class
GO:0061079 biolink:NamedThing left horn of sinus venosus development The progression of the left horn of the sinus venosus from its initial formation to the mature structure. got7fsn_ti dph 2010-04-08T02:40:27Z biological_process owl:Class
GO:0097102 biolink:NamedThing endothelial tip cell fate specification The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels. got7fsn_ti angiogenic tip cell fate specification pr 2011-07-27T10:29:00Z biological_process owl:Class
GO:0097101 biolink:NamedThing blood vessel endothelial cell fate specification The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels. got7fsn_ti pr 2011-07-27T10:24:32Z biological_process owl:Class
GO:0050221 biolink:NamedThing prostaglandin-E2 9-reductase activity Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. got7fsn_ti PGE2 9-ketoreductase activity|9-ketoprostaglandin reductase activity|PGE-9-ketoreductase activity|PGE(2) 9-oxoreductase activity|PGE(2) 9-ketoreductase activity|prostaglandin E2-9-oxoreductase activity|reductase, 15-hydroxy-9-oxoprostaglandin|PGE2 9-oxoreductase activity|PGE2-9-ketoreductase activity|prostaglandin E 9-ketoreductase activity|9-keto-prostaglandin E2 reductase activity|PGE2-9-OR|9-keto-prostaglandin E(2) reductase activity|prostaglandin-E(2) 9-oxoreductase activity|prostaglandin-E2 9-oxoreductase activity|(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 9-oxidoreductase activity EC:1.1.1.189|Reactome:R-HSA-2161651|MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN|RHEA:24508 molecular_function owl:Class
GO:0002456 biolink:NamedThing T cell mediated immunity Any process involved in the carrying out of an immune response by a T cell. got7fsn_ti cell-mediated immunity|cellular immune response|T-cell mediated immunity|T lymphocyte mediated immunity|T-lymphocyte mediated immunity biological_process owl:Class
GO:0002455 biolink:NamedThing humoral immune response mediated by circulating immunoglobulin An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus. got7fsn_ti humoral defence mechanism|humoral immune response mediated by circulating antibody|circulating antibody mediated immune response|circulating immunoglobulin mediated immune response biological_process owl:Class
GO:0006959 biolink:NamedThing humoral immune response An immune response mediated through a body fluid. got7fsn_ti Wikipedia:Humoral_immunity biological_process owl:Class
GO:0007376 biolink:NamedThing cephalic furrow formation Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome. got7fsn_ti biological_process owl:Class
GO:0033712 biolink:NamedThing 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity Catalysis of the reaction: 1,5-anhydro-D-mannitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH. got7fsn_ti AFR|1,5-anhydro-D-mannitol:NADP+ oxidoreductase activity MetaCyc:1.1.1.292-RXN|RHEA:24208|EC:1.1.1.292|KEGG_REACTION:R08194 molecular_function owl:Class
GO:0010230 biolink:NamedThing alternative respiration Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa. got7fsn_ti biological_process owl:Class
GO:0016407 biolink:NamedThing acetyltransferase activity Catalysis of the transfer of an acetyl group to an acceptor molecule. got7fsn_ti acetylase activity Reactome:R-HSA-73736|Reactome:R-HSA-6792712|Reactome:R-HSA-5660660|Reactome:R-HSA-5628871|Reactome:R-HSA-5682044|Reactome:R-HSA-6805638 molecular_function owl:Class
GO:0035474 biolink:NamedThing selective angioblast sprouting The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel. got7fsn_ti bf 2010-04-23T10:03:55Z biological_process owl:Class
GO:0019554 biolink:NamedThing glutamate catabolic process to oxaloacetate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate. got7fsn_ti glutamate breakdown to oxaloacetate|glutamate degradation to oxaloacetate biological_process owl:Class
GO:0043650 biolink:NamedThing dicarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. got7fsn_ti dicarboxylic acid synthesis|dicarboxylate biosynthetic process|dicarboxylate biosynthesis|dicarboxylic acid biosynthesis|dicarboxylic acid formation|dicarboxylic acid anabolism biological_process owl:Class
GO:0098932 biolink:NamedThing disruption by virus of host cell wall peptidoglycan during virus entry A process carried out by a virus that breaks down peptidoglycans in the cell wall of its host during viral entry. got7fsn_ti degradation of host cell wall peptidoglycan by virus|degradation of host peptidoglycans during virus entry|disassembly by virus of host cell wall peptidoglycan|catabolism of host cell wall peptidoglycan by virus VZ:3940 biological_process owl:Class
GO:0019048 biolink:NamedThing modulation by virus of host process The process in which a virus effects a change in the structure or processes of its host organism. got7fsn_ti disruption by virus of host cell|modulation by virus of host morphology or physiology|viral interaction with host|modulation by virus of host anatomy or process|host-virus interaction|virus-host interaction|viral-host process|modulation by virus of host anatomical structure or process|virus-host process https://github.com/geneontology/go-ontology/issues/18605|https://github.com/geneontology/go-ontology/issues/18719 jl 2012-08-01T13:41:00Z GO:0044661|GO:0044792 VZ:886 biological_process owl:Class
GO:0019174 biolink:NamedThing tetrahydrothiophene 1-oxide reductase activity Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor. got7fsn_ti MetaCyc:THTOREDUCT-RXN molecular_function owl:Class
GO:0050317 biolink:NamedThing tagatose kinase activity Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H(+). got7fsn_ti ATP:D-tagatose 6-phosphotransferase activity|D-tagatose 6-phosphate kinase activity|tagatose 6-phosphate kinase (phosphorylating) RHEA:15513|MetaCyc:TAGATOSE-KINASE-RXN|EC:2.7.1.101|KEGG_REACTION:R02927 molecular_function owl:Class
GO:0002079 biolink:NamedThing inner acrosomal membrane The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane. got7fsn_ti Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. cellular_component owl:Class
GO:0098035 biolink:NamedThing viral DNA genome packaging via site-specific sequence recognition The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites by a viral terminase. got7fsn_ti bm 2012-07-20T11:36:49Z biological_process owl:Class
GO:0019073 biolink:NamedThing viral DNA genome packaging The packing of viral DNA into a capsid. got7fsn_ti biological_process owl:Class
GO:0033418 biolink:NamedThing CUC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CUC codon. got7fsn_ti leucine tRNA|CTC codon-amino acid adaptor activity Note that in the standard genetic code, CTC codes for leucine. molecular_function owl:Class
GO:0102672 biolink:NamedThing fatty acid alpha-oxygenase activity Catalysis of the reaction: O2 + a 2,3,4-saturated fatty acid <=> a 2(R)-hydroperoxy fatty acid. got7fsn_ti MetaCyc:RXN-4121 molecular_function owl:Class
GO:0033446 biolink:NamedThing AGC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AGC codon. got7fsn_ti serine tRNA Note that in the standard genetic code, AGC codes for serine. molecular_function owl:Class
GO:0001126 biolink:NamedThing bacterial-type RNA polymerase preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription. got7fsn_ti bacterial-type RNA polymerase transcriptional preinitiation complex formation|bacterial-type RNA polymerase transcription PIC biosynthesis|bacterial-type RNA polymerase transcription PIC formation krc 2010-12-06T03:54:45Z biological_process owl:Class
GO:0070897 biolink:NamedThing transcription preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription. got7fsn_ti DNA-templated transcriptional preinitiation complex assembly|transcription PIC formation|transcriptional preinitiation complex formation|transcription PIC biosynthesis|DNA-dependent transcriptional preinitiation complex assembly mah 2009-09-01T04:33:47Z biological_process owl:Class
GO:0004435 biolink:NamedThing phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+). got7fsn_ti phosphoinositide phospholipase C activity|phosphatidylinositol-4,5-bisphosphate hydrolysis|1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity|1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity|triphosphoinositide phosphodiesterase activity|PI-PLC activity|monophosphatidylinositol phosphodiesterase activity|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity|phosphoinositidase C activity KEGG_REACTION:R03435|Reactome:R-HSA-1855221|Reactome:R-HSA-1855177|MetaCyc:3.1.4.11-RXN|Reactome:R-HSA-622382|Reactome:R-HSA-5607735|Reactome:R-HSA-1855214|EC:3.1.4.11|Reactome:R-HSA-111879|Reactome:R-HSA-167686|RHEA:33179|Reactome:R-HSA-202407|Reactome:R-HSA-2730847|Reactome:R-HSA-9032478 molecular_function owl:Class
GO:0004629 biolink:NamedThing phospholipase C activity Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. got7fsn_ti lipophosphodiesterase C|phosphatidase C|lecithinase C activity GO:0042298 Reactome:R-HSA-1112666|EC:3.1.4.3|Reactome:R-HSA-5362553|Reactome:R-HSA-114689|Reactome:R-HSA-399998|Reactome:R-HSA-398193|MetaCyc:PHOSPHOLIPASE-C-RXN|Reactome:R-HSA-114688 molecular_function owl:Class
GO:1900766 biolink:NamedThing emericellin biosynthetic process The chemical reactions and pathways resulting in the formation of emericellin. got7fsn_ti Variecoxanthone B formation|emericellin biosynthesis|Variecoxanthone B biosynthetic process|emericellin synthesis|Variecoxanthone B synthesis|Variecoxanthone B biosynthesis|emericellin formation|emericellin anabolism|Variecoxanthone B anabolism di 2012-06-04T09:18:29Z biological_process owl:Class
GO:0051681 biolink:NamedThing 6-alpha-maltosylglucose catabolic process The chemical reactions and pathways resulting in the breakdown of 6-alpha-maltosylglucose, also known as isopanose. got7fsn_ti isopanose catabolism|isopanose catabolic process biological_process owl:Class
GO:0033549 biolink:NamedThing MAP kinase phosphatase activity Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. got7fsn_ti MAPK phosphatase activity molecular_function owl:Class
GO:0043662 biolink:NamedThing peribacteroid fluid The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome. got7fsn_ti cellular_component owl:Class
GO:0033309 biolink:NamedThing SBF transcription complex A protein complex that binds to the Swi4/6 cell cycle box (SCB) promoter element, consensus sequence CRCGAAA, and activates transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Swi4p and the activator Swi6p, and is associated with additional proteins known as Whi5p and Msa1p. got7fsn_ti SBF complex cellular_component owl:Class
GO:0050620 biolink:NamedThing phycocyanobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. got7fsn_ti (3Z)-phycocyanobilin:ferredoxin oxidoreductase activity EC:1.3.7.5|RHEA:15309|MetaCyc:1.3.7.5-RXN molecular_function owl:Class
GO:0016636 biolink:NamedThing oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. got7fsn_ti oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor EC:1.3.7.- molecular_function owl:Class
GO:0097609 biolink:NamedThing longitudinal flagellum A motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus. got7fsn_ti longitudinal cilium Note that we deem cilium and microtubule-based flagellum to be equivalent. In this case community usage refers to 'flagellum' rather than 'cilium', hence the primary term name, but the cilium parentage is deliberate. pr 2014-06-09T11:21:10Z cellular_component owl:Class
GO:0010071 biolink:NamedThing root meristem specification The specification of a meristem which will give rise to a primary or lateral root. got7fsn_ti biological_process owl:Class
GO:1990725 biolink:NamedThing cord factor receptor activity Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti trehalose 6,6'-dimycolate receptor activity|TMD receptor activity hjd 2015-04-07T20:53:31Z Wikipedia:Cord_factor molecular_function owl:Class
GO:0001778 biolink:NamedThing plasma membrane repair The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress. got7fsn_ti biological_process owl:Class
GO:0007009 biolink:NamedThing plasma membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. got7fsn_ti plasma membrane organization and biogenesis|plasma membrane organisation biological_process owl:Class
GO:0052788 biolink:NamedThing d-4,5 unsaturated beta-glucuronyl hydrolase activity Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue. got7fsn_ti unsaturated beta-glucuronyl hydrolase activity ai 2011-10-04T12:59:37Z molecular_function owl:Class
GO:0018142 biolink:NamedThing protein-DNA covalent cross-linking The formation of a covalent cross-link between DNA and a protein. got7fsn_ti DNA-protein covalent cross-linking biological_process owl:Class
GO:0006626 biolink:NamedThing protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. got7fsn_ti protein-mitochondrial targeting|protein targeting to mitochondria|protein import into mitochondrion|mitochondrial translocation|mitochondrial protein import GO:0043681 biological_process owl:Class
GO:0072655 biolink:NamedThing establishment of protein localization to mitochondrion The directed movement of a protein to the mitochondrion or a part of the mitochondrion. got7fsn_ti establishment of protein localization in mitochondrion|establishment of protein localisation to mitochondrion mah 2011-02-14T02:28:54Z biological_process owl:Class
GO:0034174 biolink:NamedThing toll-like receptor 12 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 12. got7fsn_ti TLR12 signaling pathway|toll-like receptor 12 signalling pathway biological_process owl:Class
GO:0033730 biolink:NamedThing arogenate dehydrogenase (NADP+) activity Catalysis of the reaction: L-arogenate + NADP+ = L-tyrosine + NADPH + CO2. got7fsn_ti TyrAAT2|L-arogenate:NADP+ oxidoreductase (decarboxylating) activity|TyrAa|pretyrosine dehydrogenase activity|arogenic dehydrogenase activity|TyrAAT1 MetaCyc:1.3.1.78-RXN|EC:1.3.1.78|RHEA:15417 molecular_function owl:Class
GO:0033731 biolink:NamedThing arogenate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2. got7fsn_ti pretyrosine dehydrogenase activity|arogenic dehydrogenase activity|L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) activity EC:1.3.1.79|MetaCyc:1.3.1.79-RXN molecular_function owl:Class
GO:0090133 biolink:NamedThing mesendoderm migration The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm. got7fsn_ti tb 2009-12-07T03:22:08Z biological_process owl:Class
GO:0090132 biolink:NamedThing epithelium migration The process in which the population of cells that make up an epithelium undergo directed movement. got7fsn_ti tb 2009-12-07T03:19:34Z biological_process owl:Class
GO:0072012 biolink:NamedThing glomerulus vasculature development The biological process whose specific outcome is the progression of a glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the glomerulus vasculature and ends with the mature structure. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus. got7fsn_ti glomerulus capillary development mah 2010-01-25T02:05:04Z biological_process owl:Class
GO:0102173 biolink:NamedThing 24-methylenecycloartanol 4alpha-methyl oxidase activity Catalysis of the reaction: 24-methylenecycloartanol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O. got7fsn_ti RHEA:58836|MetaCyc:RXN-11926 molecular_function owl:Class
GO:0019983 biolink:NamedThing interleukin-9 binding Binding to interleukin-9. got7fsn_ti IL-9 binding molecular_function owl:Class
GO:0019590 biolink:NamedThing L-arabitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate. got7fsn_ti L-arabitol and xylitol degradation|L-arabitol degradation to xylulose 5-phosphate|L-arabitol breakdown to xylulose 5-phosphate|L-arabitol utilization MetaCyc:LARABITOLUTIL-PWY biological_process owl:Class
GO:0102916 biolink:NamedThing sesamin synthase activity Catalysis of the reaction: H+ + (+)-piperitol + NADPH + O2 <=> (+)-sesamin + NADP + 2 H2O. got7fsn_ti MetaCyc:RXN-8696|EC:1.14.19.74 molecular_function owl:Class
GO:0050123 biolink:NamedThing N-acylmannosamine 1-dehydrogenase activity Catalysis of the reaction: N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + H(+) + NADH. got7fsn_ti N-acetyl-D-mannosamine dehydrogenase activity|N-acyl-D-mannosamine:NAD+ 1-oxidoreductase activity|N-acyl-D-mannosamine dehydrogenase activity|N-acylmannosamine dehydrogenase activity KEGG_REACTION:R02651|RHEA:11540|MetaCyc:N-ACYLMANNOSAMINE-1-DEHYDROGENASE-RXN|EC:1.1.1.233 molecular_function owl:Class
GO:0018120 biolink:NamedThing peptidyl-arginine ADP-ribosylation The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine. got7fsn_ti RESID:AA0168 biological_process owl:Class
GO:0018800 biolink:NamedThing 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. got7fsn_ti HpaG-2|HpaG2|5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity|5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)|OPET decarboxylase activity|5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity|5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity RHEA:14397|MetaCyc:4.1.1.68-RXN|UM-BBD_reactionID:r0367|EC:4.1.1.68 molecular_function owl:Class
GO:0097393 biolink:NamedThing telomeric repeat-containing RNA transcription The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome. got7fsn_ti TERRA transcription pr 2012-10-23T10:06:17Z biological_process owl:Class
GO:0009112 biolink:NamedThing nucleobase metabolic process The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. got7fsn_ti nucleobase metabolism biological_process owl:Class
GO:0061042 biolink:NamedThing vascular wound healing Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. got7fsn_ti dph 2010-02-25T10:18:26Z biological_process owl:Class
GO:0060055 biolink:NamedThing angiogenesis involved in wound healing Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. got7fsn_ti biological_process owl:Class
GO:0046752 biolink:NamedThing viral capsid precursor transport to host cell nucleus Any process in which viral capsid precursors are transported to a specific location in the nucleus, thus accumulating the necessary components for assembly of a capsid. got7fsn_ti localization of viral capsid precursors in nucleus|viral capsid precursor localization to host cell nucleus|nuclear localization of viral capsid precursors|viral capsid precursor localisation in host cell nucleus|establishment and maintenance of viral capsid precursor localization in nucleus|viral capsid precursor localization in host cell nucleus biological_process owl:Class
GO:0090635 biolink:NamedThing extracellular core region of desmosome The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner. got7fsn_ti desmoglea tb 2015-04-20T16:10:51Z cellular_component owl:Class
GO:1901164 biolink:NamedThing negative regulation of trophoblast cell migration Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration. got7fsn_ti inhibition of trophoblast cell migration|down-regulation of trophoblast cell migration|downregulation of trophoblast cell migration|down regulation of trophoblast cell migration vk 2012-07-19T07:53:28Z biological_process owl:Class
GO:0002344 biolink:NamedThing B cell affinity maturation The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen. got7fsn_ti B-cell affinity maturation|B lymphocyte affinity maturation|B-lymphocyte affinity maturation biological_process owl:Class
GO:0002343 biolink:NamedThing peripheral B cell selection Any B cell selection process that occurs in the periphery. got7fsn_ti peripheral B lymphocyte selection|peripheral B-cell selection|peripheral B-lymphocyte selection biological_process owl:Class
GO:0071748 biolink:NamedThing monomeric IgA immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti monomeric IgA2 antibody|monomeric IgA antibody|monomeric IgA1 antibody Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0071746 biolink:NamedThing IgA immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgA1 antibody|IgA2 antibody|IgA antibody Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0046191 biolink:NamedThing aerobic phenol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen. got7fsn_ti aerobic phenol-containing compound catabolism|aerobic phenol-containing compound breakdown|aerobic phenol-containing compound degradation biological_process owl:Class
GO:0019336 biolink:NamedThing phenol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. got7fsn_ti phenol-containing compound catabolism|phenol-containing compound degradation|phenol-containing compound breakdown MetaCyc:PHENOLDEG-PWY biological_process owl:Class
GO:0102149 biolink:NamedThing farnesylcysteine lyase activity Catalysis of the reaction: S-[(2E,6E)-farnesyl]-L-cysteine + O2 + H2O <=> (2-trans,6-trans)-farnesal + L-cysteine + hydrogen peroxide. got7fsn_ti EC:1.8.3.6|RHEA:30231|MetaCyc:RXN-11623 molecular_function owl:Class
GO:0016670 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. got7fsn_ti oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor EC:1.8.3.- molecular_function owl:Class
GO:0017189 biolink:NamedThing N-terminal peptidyl-alanine acetylation The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase. got7fsn_ti See also the molecular function terms 'peptide alpha-N-acetyltransferase activity ; GO:0004596' and 'ribosomal-protein-alanine N-acetyltransferase activity ; GO:0008999'. RESID:AA0041 biological_process owl:Class
GO:0032250 biolink:NamedThing negative regulation of adenosine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti inhibition of adenosine transport|downregulation of adenosine transport|down-regulation of adenosine transport|down regulation of adenosine transport biological_process owl:Class
GO:0032247 biolink:NamedThing negative regulation of purine nucleoside transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti downregulation of purine nucleoside transport|down regulation of purine nucleoside transport|down-regulation of purine nucleoside transport|inhibition of purine nucleoside transport biological_process owl:Class
GO:0019136 biolink:NamedThing deoxynucleoside kinase activity Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. got7fsn_ti multifunctional deoxynucleoside kinase activity|multispecific deoxynucleoside kinase activity|ms-dNK|multisubstrate deoxyribonucleoside kinase activity|D. melanogaster deoxynucleoside kinase activity|ATP:deoxynucleoside 5'-phosphotransferase activity|Dm-dNK|Ms-dNK activity MetaCyc:2.7.1.145-RXN|RHEA:12140|EC:2.7.1.145 molecular_function owl:Class
GO:0030007 biolink:NamedThing cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell. got7fsn_ti GO:0017079 biological_process owl:Class
GO:0055075 biolink:NamedThing potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0034236 biolink:NamedThing protein kinase A catalytic subunit binding Binding to one or both of the catalytic subunits of protein kinase A. got7fsn_ti PKA catalytic subunit binding molecular_function owl:Class
GO:0051018 biolink:NamedThing protein kinase A binding Binding to a protein kinase A. got7fsn_ti PKA binding|protein kinase A anchoring activity Note that this term is a direct child of 'protein binding ; GO:0005515' because it encompasses binding to either the catalytic or regulatory subunit of protein kinase A, and the latter does not have kinase activity. molecular_function owl:Class
GO:0046289 biolink:NamedThing isoflavonoid phytoalexin metabolic process The chemical reactions and pathways involving isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. got7fsn_ti isoflavonoid phytoalexin metabolism biological_process owl:Class
GO:0046287 biolink:NamedThing isoflavonoid metabolic process The chemical reactions and pathways involving isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids, containing a flavan skeleton. They are differentiated from flavonoids by the point of attachment of the aromatic ring group. got7fsn_ti isoflavonoid metabolism biological_process owl:Class
GO:0010056 biolink:NamedThing atrichoblast fate specification The process involved in the specification of an atrichoblast. got7fsn_ti biological_process owl:Class
GO:0030624 biolink:NamedThing U6atac snRNA binding Binding to a U6atac small nuclear RNA (U6atac snRNA). got7fsn_ti molecular_function owl:Class
GO:0004453 biolink:NamedThing juvenile-hormone esterase activity Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone. got7fsn_ti JH esterase activity|juvenile hormone analog esterase activity|JH-esterase activity|juvenile hormone carboxyesterase activity|methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity EC:3.1.1.59|RHEA:16393|MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN molecular_function owl:Class
GO:1903231 biolink:NamedThing mRNA binding involved in posttranscriptional gene silencing Any mRNA binding that is involved in posttranscriptional gene silencing. got7fsn_ti mRNA binding involved in post-transcriptional gene silencing|mRNA binding involved in PTGS|mRNA binding involved in quelling|mRNA binding involved in cosuppression jl 2014-07-31T10:30:43Z molecular_function owl:Class
GO:0150100 biolink:NamedThing RNA binding involved in posttranscriptional gene silencing Any RNA binding that is involved in posttranscriptional gene silencing. got7fsn_ti RNA binding involved in cosuppression|RNA binding involved in PTGS|RNA binding involved in quelling|RNA binding involved in post-transcriptional gene silencing bc 2019-03-11T11:48:27Z molecular_function owl:Class
GO:0070388 biolink:NamedThing procollagen-proline 4-dioxygenase complex, alpha(III) type A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type III isoform. got7fsn_ti prolyl 4-hydroxylase complex (alpha(III)-type)|procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(III) type cellular_component owl:Class
GO:0016222 biolink:NamedThing procollagen-proline 4-dioxygenase complex A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase. got7fsn_ti procollagen-proline, 2-oxoglutarate-4-dioxygenase complex|prolyl 4-hydroxylase complex cellular_component owl:Class
GO:0008759 biolink:NamedThing UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. got7fsn_ti EC:3.5.1.108 molecular_function owl:Class
GO:0034995 biolink:NamedThing SC5b-7 complex A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly. got7fsn_ti cellular_component owl:Class
GO:0072202 biolink:NamedThing cell differentiation involved in metanephros development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephros as it progresses from its formation to the mature state. got7fsn_ti mah 2010-03-18T10:40:14Z biological_process owl:Class
GO:0051469 biolink:NamedThing vesicle fusion with vacuole The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole. got7fsn_ti heterotypic vacuole fusion (non-autophagic)|heterotypic vacuole fusion, non-autophagic GO:0042146 biological_process owl:Class
GO:0006906 biolink:NamedThing vesicle fusion Fusion of the membrane of a transport vesicle with its target membrane. got7fsn_ti biological_process owl:Class
GO:0033886 biolink:NamedThing cellulose-polysulfatase activity Catalysis of the hydrolysis of the 2- and 3-sulfate groups of the polysulfates of cellulose and charonin. got7fsn_ti cellulose-sulfate sulfohydrolase activity MetaCyc:3.1.6.7-RXN|EC:3.1.6.7 molecular_function owl:Class
GO:0032159 biolink:NamedThing septin cap A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. got7fsn_ti cellular_component owl:Class
GO:0052053 biolink:NamedThing negative regulation by symbiont of host catalytic activity Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti inhibition of host enzyme activity|down-regulation by symbiont of host enzyme activity|downregulation by symbiont of host enzyme activity|down regulation by symbiont of host enzyme activity|negative regulation by symbiont of host enzyme activity|inhibition by symbiont of host enzyme activity|negative regulation by symbiont of host molecular function GO:0052056 biological_process owl:Class
GO:0021629 biolink:NamedThing olfactory nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. got7fsn_ti CN I structural organization|olfactory nerve structural organisation biological_process owl:Class
GO:0043714 biolink:NamedThing (R)-citramalate synthase activity Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA. got7fsn_ti citramalate synthase MetaCyc:RXN-7743|EC:2.3.1.182|RHEA:19045 molecular_function owl:Class
GO:0004506 biolink:NamedThing squalene monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+). got7fsn_ti squalene oxydocyclase activity|squalene-2,3-epoxidase activity|squalene-2,3-epoxide cyclase activity|squalene hydroxylase activity|squalene 2,3-oxidocyclase activity|squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity|squalene epoxidase activity RHEA:25282|MetaCyc:SQUALENE-MONOOXYGENASE-RXN|Reactome:R-HSA-191299|KEGG_REACTION:R02874|EC:1.14.14.17 molecular_function owl:Class
GO:0007430 biolink:NamedThing terminal branching, open tracheal system Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster. got7fsn_ti terminal branching of trachea, cytoplasmic projection extension biological_process owl:Class
GO:0097179 biolink:NamedThing protease inhibitor complex A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity. got7fsn_ti peptidase inhibitor complex pr 2011-10-16T08:53:44Z cellular_component owl:Class
GO:0033557 biolink:NamedThing Slx1-Slx4 complex A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes. got7fsn_ti cellular_component owl:Class
GO:0038202 biolink:NamedThing TORC1 signaling A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. got7fsn_ti TORC1 signal transduction bf 2013-12-09T14:43:29Z biological_process owl:Class
GO:0050931 biolink:NamedThing pigment cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte. got7fsn_ti chromatophore differentiation|pigmented cell differentiation Note that the chromatophore mentioned here is distinct from the pigment bearing structure found in certain photosynthetic bacteria and cyanobacteria. It is also different from the plant chromoplast, which is also sometimes called a chromatophore. GO:0043358|GO:0043357 biological_process owl:Class
GO:0001880 biolink:NamedThing Mullerian duct regression The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos. got7fsn_ti biological_process owl:Class
GO:0060033 biolink:NamedThing anatomical structure regression The developmental process in which an anatomical stucture is destroyed as a part of its normal progression. got7fsn_ti histolysis|tissue death biological_process owl:Class
GO:0002062 biolink:NamedThing chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. got7fsn_ti biological_process owl:Class
GO:0006303 biolink:NamedThing double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear. got7fsn_ti NHEJ biological_process owl:Class
GO:0006302 biolink:NamedThing double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. got7fsn_ti Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'. biological_process owl:Class
GO:0002202 biolink:NamedThing somatic diversification of variable lymphocyte receptors of jawless fish The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish. got7fsn_ti Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762). biological_process owl:Class
GO:0097221 biolink:NamedThing M/G1 phase-specific MADS box-forkhead transcription factor complex A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2. got7fsn_ti PBF transcription complex|pombe cell cycle box binding factor complex|PBF complex|PCB binding factor complex pr 2012-01-18T08:18:27Z cellular_component owl:Class
GO:0018228 biolink:NamedThing peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification. got7fsn_ti peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine|peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine RESID:AA0104 biological_process owl:Class
GO:0055082 biolink:NamedThing cellular chemical homeostasis Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell. got7fsn_ti biological_process owl:Class
GO:0102451 biolink:NamedThing kaempferide 3-O-methyltransferase activity Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 3,4'-dimethylkaempferol + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13937 molecular_function owl:Class
GO:1990399 biolink:NamedThing epithelium regeneration The regrowth of lost or destroyed epithelium. got7fsn_ti regeneration of epithelium sl 2014-06-12T17:14:42Z biological_process owl:Class
GO:0060489 biolink:NamedThing planar dichotomous subdivision of terminal units involved in lung branching morphogenesis The process in which a lung bud bifurcates parallel to the plane of the previous bud. got7fsn_ti biological_process owl:Class
GO:0060448 biolink:NamedThing dichotomous subdivision of terminal units involved in lung branching The process in which a lung bud bifurcates. got7fsn_ti bud bifurcation involved in lung branching biological_process owl:Class
GO:0048562 biolink:NamedThing embryonic organ morphogenesis Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti biological_process owl:Class
GO:0008725 biolink:NamedThing DNA-3-methyladenine glycosylase activity Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site. got7fsn_ti DNA glycosidase I activity|3-methyladenine DNA glycosylase I|DNA-3-methyladenine glycosylase I activity|alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)|deoxyribonucleate 3-methyladenine glycosidase I|DNA-3-methyladenine glycosidase I activity MetaCyc:3.2.2.21-RXN|EC:3.2.2.21|EC:3.2.2.20|MetaCyc:3.2.2.20-RXN molecular_function owl:Class
GO:0043733 biolink:NamedThing DNA-3-methylbase glycosylase activity Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site. got7fsn_ti Mag III|DNA-3-methyladenine glycosylase III|MagIII molecular_function owl:Class
GO:0009853 biolink:NamedThing photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. got7fsn_ti MetaCyc:PWY-181|Wikipedia:Photorespiration biological_process owl:Class
GO:0070659 biolink:NamedThing inner ear sensory epithelium regeneration The regrowth of lost or destroyed inner ear sensory epithelia. got7fsn_ti mah 2009-05-28T04:21:09Z biological_process owl:Class
GO:0021529 biolink:NamedThing spinal cord oligodendrocyte cell differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0034859 biolink:NamedThing benzothiazole monooxygenase activity Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole. got7fsn_ti UM-BBD_reactionID:r1292 molecular_function owl:Class
GO:0050185 biolink:NamedThing phosphatidylinositol deacylase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+). got7fsn_ti 1-phosphatidyl-D-myo-inositol 2-acylhydrolase activity|phosphatidylinositol phospholipase A2 activity KEGG_REACTION:R03360|EC:3.1.1.52|MetaCyc:PHOSPHATIDYLINOSITOL-DEACYLASE-RXN|RHEA:18001 molecular_function owl:Class
GO:0052874 biolink:NamedThing FMN reductase (NADH) activity Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+. got7fsn_ti NADH2 dehydrogenase (FMN)|NADH2:FMN oxidoreductase activity|NADH dehydrogenase (FMN) activity|SsuE|flavin mononucleotide reductase activity|NADH(2):FMN oxidoreductase activity|NADH-dependent FMN reductase activity|FMNH2:NAD+ oxidoreductase activity|NADH:flavin oxidoreductase activity|NADH-FMN reductase activity|NADH:FMN oxidoreductase activity|flavine mononucleotide reductase activity|NADH(2) dehydrogenase (FMN) activity EC:1.5.1.39|RHEA:21620|KEGG_REACTION:R05705 molecular_function owl:Class
GO:0098624 biolink:NamedThing 3'-phosphoadenylylselenate reductase activity Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+. got7fsn_ti PAPSe reductase activity Reactome:R-HSA-2408548 molecular_function owl:Class
GO:0032620 biolink:NamedThing interleukin-17 production The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CTLA-8 production|IL-17 production|Cytotoxic T-lymphocyte-associated antigen 8 production|interleukin-17 secretion|interleukin-17 biosynthetic process GO:0072615|GO:0042235 biological_process owl:Class
GO:0120039 biolink:NamedThing plasma membrane bounded cell projection morphogenesis The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized. got7fsn_ti https://github.com/geneontology/go-ontology/issues/13298 krc 2017-04-28T23:39:37Z biological_process owl:Class
GO:0048858 biolink:NamedThing cell projection morphogenesis The process in which the anatomical structures of a cell projection are generated and organized. got7fsn_ti biological_process owl:Class
GO:0060117 biolink:NamedThing auditory receptor cell development The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti auditory hair cell development biological_process owl:Class
GO:0060119 biolink:NamedThing inner ear receptor cell development The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti inner ear hair cell development biological_process owl:Class
GO:0048060 biolink:NamedThing negative gravitaxis The directed movement of a motile cell or organism away from the source of gravity. got7fsn_ti negative geotactic behaviour|negative gravitactic behaviour|negative taxis in response to gravity|negative geotactic behavior|negative gravitactic behavior|negative taxis in response to gravitytaxis in response to gravitational stimulus GO:0048063 biological_process owl:Class
GO:0042332 biolink:NamedThing gravitaxis The directed movement of a motile cell or organism in response to gravity. got7fsn_ti geotactic behaviour|taxis in response to gravitational stimulus|gravitactic behaviour|geotaxis|geotactic behavior|taxis in response to gravity|gravitactic behavior GO:0048062 biological_process owl:Class
GO:0102688 biolink:NamedThing dihydrozeatin UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + 9-(alpha-D-glucosyl)dihydrozeatin + UDP. got7fsn_ti MetaCyc:RXN-4725 molecular_function owl:Class
GO:0044860 biolink:NamedThing protein localization to plasma membrane raft A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft. got7fsn_ti jl 2014-07-23T16:25:01Z biological_process owl:Class
GO:1903044 biolink:NamedThing protein localization to membrane raft A process in which a protein is transported to, or maintained in, a location within a membrane raft. got7fsn_ti protein localisation to membrane raft|protein localization in membrane raft|protein localisation in membrane raft dl 2014-05-21T10:49:03Z biological_process owl:Class
GO:0033114 biolink:NamedThing cyanelle thylakoid lumen The volume enclosed by a cyanelle thylakoid membrane. got7fsn_ti cellular_component owl:Class
GO:0102180 biolink:NamedThing 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity Catalysis of the reaction: 4alpha-hydroxymethyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NAD + 2 H2O. got7fsn_ti RHEA:59036|MetaCyc:RXN-11936 molecular_function owl:Class
GO:0061060 biolink:NamedThing negative regulation of peptidoglycan recognition protein signaling pathway Any process that decreases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. got7fsn_ti negative regulation of peptidoglycan recognition protein signalling pathway dph 2010-03-02T12:38:42Z biological_process owl:Class
GO:0002832 biolink:NamedThing negative regulation of response to biotic stimulus Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus. got7fsn_ti inhibition of response to biotic stimulus|down-regulation of response to biotic stimulus|downregulation of response to biotic stimulus|down regulation of response to biotic stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0060832 biolink:NamedThing oocyte animal/vegetal axis specification The establishment, maintenance and elaboration of the animal/vegetal axis in the oocyte. The animal/vegetal axis of an oocyte is defined by the placement of the nucleus in the oocyte and can sometimes be identified by the asymmetric placement of other substances such as yolk in the oocyte. The pole of the egg that is closest to the nucleus defines the animal end, with the axis passing through the nucleus. got7fsn_ti dph 2009-08-11T03:11:06Z biological_process owl:Class
GO:0009295 biolink:NamedThing nucleoid The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined. got7fsn_ti Wikipedia:Nucleoid cellular_component owl:Class
GO:0071705 biolink:NamedThing nitrogen compound transport The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti mah 2010-03-08T03:56:28Z biological_process owl:Class
GO:0036410 biolink:NamedThing Mst2 histone acetyltransferase complex A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6. got7fsn_ti Mst2 complex|Mst2 histone H3K14 acetyltransferase complex|Mst2 H3K14 acetyltransferase complex bf 2013-08-21T10:11:32Z cellular_component owl:Class
GO:0047760 biolink:NamedThing butyrate-CoA ligase activity Catalysis of the reaction: ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA. got7fsn_ti fatty acid activating enzyme|butanoate:CoA ligase (AMP-forming)|acyl-activating enzyme activity|butyryl-CoA synthetase activity|medium chain acyl-CoA synthetase activity|short-chain acyl-CoA synthetase activity|fatty acid thiokinase (medium chain) activity|butyryl-coenzyme A synthetase activity|fatty acyl coenzyme A synthetase activity|L-(+)-3-hydroxybutyryl CoA ligase activity MetaCyc:BUTYRATE--COA-LIGASE-RXN|RHEA:24336|EC:6.2.1.2|Reactome:R-HSA-8875013 molecular_function owl:Class
GO:0007425 biolink:NamedThing epithelial cell fate determination, open tracheal system The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster. got7fsn_ti tracheal epithelial cell fate determination|tracheal cell fate determination|tracheal placode cell fate determination GO:0046846 biological_process owl:Class
GO:0043083 biolink:NamedThing synaptic cleft The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. got7fsn_ti NIF_Subcellular:sao243541954 cellular_component owl:Class
GO:0005576 biolink:NamedThing extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. got7fsn_ti extracellular Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. Wikipedia:Extracellular cellular_component owl:Class
GO:0052699 biolink:NamedThing ergothioneine biosynthetic process The chemical reactions and pathways resulting in the formation of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties. got7fsn_ti ergothioneine biosynthesis|ergothioneine anabolism|2-mercaptoergothioneine trimethylbetaine biosynthetic process|ergothioneine formation|(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate biosynthetic process|2-mercaptoergothioneine trimethylbetaine formation|2-mercaptoergothioneine trimethylbetaine anabolism|2-mercaptoergothioneine trimethylbetaine synthesis|2-mercaptoergothioneine trimethylbetaine biosynthesis|ergothioneine synthesis ai 2011-08-01T03:56:19Z biological_process owl:Class
GO:0052703 biolink:NamedThing cellular modified histidine biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. got7fsn_ti cellular histidine derivative anabolism|cellular modified histidine synthesis|histidine derivative biosynthetic process|cellular modified histidine anabolism|cellular histidine derivative biosynthetic process|cellular modified histidine biosynthesis|cellular histidine derivative biosynthesis|cellular histidine derivative formation|cellular modified histidine formation|cellular histidine derivative synthesis ai 2011-08-01T03:49:39Z biological_process owl:Class
GO:0055079 biolink:NamedThing aluminum ion homeostasis Any process involved in the maintenance of an internal steady state of aluminum ions within an organism or cell. got7fsn_ti aluminium ion homeostasis biological_process owl:Class
GO:0044208 biolink:NamedThing 'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP). got7fsn_ti jl 2009-10-22T02:48:30Z biological_process owl:Class
GO:0006167 biolink:NamedThing AMP biosynthetic process The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate. got7fsn_ti AMP formation|AMP anabolism|AMP synthesis|AMP biosynthesis biological_process owl:Class
GO:0044352 biolink:NamedThing pinosome A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis. got7fsn_ti pinocytic vesicle jl 2011-08-11T10:51:13Z NIF_Subcellular:sao1925368674 cellular_component owl:Class
GO:0005768 biolink:NamedThing endosome A vacuole to which materials ingested by endocytosis are delivered. got7fsn_ti NIF_Subcellular:sao1720343330|Wikipedia:Endosome cellular_component owl:Class
GO:0009047 biolink:NamedThing dosage compensation by hyperactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0007549 biolink:NamedThing dosage compensation Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes. got7fsn_ti Wikipedia:Dosage_compensation biological_process owl:Class
GO:0048579 biolink:NamedThing negative regulation of long-day photoperiodism, flowering Any process that stops, prevents or reduces long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. got7fsn_ti down regulation of long-day photoperiodism, flowering|inhibition of long-day photoperiodism, flowering|downregulation of long-day photoperiodism, flowering|down-regulation of long-day photoperiodism, flowering biological_process owl:Class
GO:0060776 biolink:NamedThing simple leaf morphogenesis The leaf morphogenesis process which results in the shaping of a simple leaf. A simple leaf is a leaf in which the lamina is undivided. got7fsn_ti dph 2009-07-25T07:08:44Z biological_process owl:Class
GO:0008310 biolink:NamedThing single-stranded DNA 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. got7fsn_ti ssDNA-specific 3'-5' exodeoxyribonuclease activity|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity molecular_function owl:Class
GO:0033161 biolink:NamedThing mitogen-activated protein kinase kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase. got7fsn_ti MAPKKKK binding molecular_function owl:Class
GO:0030377 biolink:NamedThing urokinase plasminogen activator receptor activity Combining with the urokinase plasminogen activator to initiate a change in cell activity. got7fsn_ti U-plasminogen activator receptor activity|urokinase plasminogen activator receptor|uPAR Wikipedia:Urokinase_receptor molecular_function owl:Class
GO:0002474 biolink:NamedThing antigen processing and presentation of peptide antigen via MHC class I The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. got7fsn_ti peptide antigen processing and presentation via MHC class I biological_process owl:Class
GO:0019969 biolink:NamedThing interleukin-10 binding Binding to interleukin-10. got7fsn_ti IL-10 binding molecular_function owl:Class
GO:0032891 biolink:NamedThing negative regulation of organic acid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti downregulation of organic acid transport|down regulation of organic acid transport|inhibition of organic acid transport|down-regulation of organic acid transport biological_process owl:Class
GO:0002776 biolink:NamedThing antimicrobial peptide secretion The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. got7fsn_ti biological_process owl:Class
GO:0061956 biolink:NamedThing penetration of cumulus oophorus The infiltration by sperm of the cumulus oophorus to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. got7fsn_ti penetration of cumulus cells layer|penetration of cumulus mass dph 2017-11-10T20:14:18Z biological_process owl:Class
GO:1900797 biolink:NamedThing cordyol C metabolic process The chemical reactions and pathways involving cordyol C. got7fsn_ti cordyol C metabolism di 2012-06-04T09:47:48Z biological_process owl:Class
GO:0046364 biolink:NamedThing monosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. got7fsn_ti monosaccharide formation|monosaccharide synthesis|monosaccharide biosynthesis|monosaccharide anabolism biological_process owl:Class
GO:0060984 biolink:NamedThing epicardium-derived cardiac vascular smooth muscle cell development The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell that was derived from the epicardium over time, from its formation to the mature state. got7fsn_ti dph 2009-10-06T03:07:09Z biological_process owl:Class
GO:0060948 biolink:NamedThing cardiac vascular smooth muscle cell development The process whose specific outcome is the progression of a cardiac vascular smooth muscle cell over time, from its formation to the mature state. got7fsn_ti heart vascular smooth muscle cell development dph 2009-09-29T03:00:24Z biological_process owl:Class
GO:0000007 biolink:NamedThing low-affinity zinc ion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti molecular_function owl:Class
GO:0039504 biolink:NamedThing suppression by virus of host adaptive immune response Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory). got7fsn_ti inhibition of host adaptive immune response by virus|negative regulation by virus of host adaptive immunity|suppression by virus of host acquired immune response|negative regulation by virus of host adaptive immune response bf 2011-05-11T04:41:54Z biological_process owl:Class
GO:0002820 biolink:NamedThing negative regulation of adaptive immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response. got7fsn_ti inhibition of adaptive immune response|downregulation of adaptive immune response|down-regulation of adaptive immune response|down regulation of adaptive immune response biological_process owl:Class
GO:0010362 biolink:NamedThing negative regulation of anion channel activity by blue light Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity. got7fsn_ti negative regulation by blue light of anion channel activity|inhibition by blue light of anion channel activity biological_process owl:Class
GO:0010360 biolink:NamedThing negative regulation of anion channel activity Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity. got7fsn_ti biological_process owl:Class
GO:0052921 biolink:NamedThing acetone-cyanohydrin acetone-lyase (cyanide-forming) activity Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + acetone. got7fsn_ti RHEA:11932|KEGG_REACTION:R01553|EC:4.1.2.46|MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN molecular_function owl:Class
GO:0052919 biolink:NamedThing aliphatic (R)-hydroxynitrile lyase activity Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide. got7fsn_ti (R)-oxynitrilase activity|(R)-hydroxynitrile lyase activity|(R)-HNL activity EC:4.1.2.46 molecular_function owl:Class
GO:0036131 biolink:NamedThing prostaglandin D2 11-ketoreductase activity Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+. got7fsn_ti prostaglandin 11-keto reductase|PGD2 11-ketoreductase bf 2012-03-05T10:27:29Z EC:1.1.1.188|RHEA:45316|KEGG_REACTION:R02799|Reactome:R-HSA-2161614 molecular_function owl:Class
GO:0034714 biolink:NamedThing type III transforming growth factor beta receptor binding Binding to a type III transforming growth factor beta receptor. got7fsn_ti TGF-beta type III binding|transforming growth factor beta ligand binding to type III receptor|type IIII TGF-beta binding|transforming growth factor beta receptor type III binding|betaglycan binding molecular_function owl:Class
GO:0005160 biolink:NamedThing transforming growth factor beta receptor binding Binding to a transforming growth factor beta receptor. got7fsn_ti TGFbeta receptor binding|activin|TGF-beta receptor binding|transforming growth factor beta receptor ligand|inhibin|transforming growth factor beta|transforming growth factor beta receptor anchoring activity|transforming growth factor beta ligand binding to type II receptor|transforming growth factor beta ligand binding to type I receptor molecular_function owl:Class
GO:0097361 biolink:NamedThing CIA complex The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity. got7fsn_ti cytosolic iron-sulfur protein assembly complex pr 2012-07-20T02:07:22Z cellular_component owl:Class
GO:0048917 biolink:NamedThing posterior lateral line ganglion development The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear. got7fsn_ti gPLL development biological_process owl:Class
GO:0048336 biolink:NamedThing positive regulation of mesodermal cell fate determination Any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination. got7fsn_ti stimulation of mesodermal cell fate determination|up regulation of mesodermal cell fate determination|up-regulation of mesodermal cell fate determination|activation of mesodermal cell fate determination|upregulation of mesodermal cell fate determination biological_process owl:Class
GO:0045597 biolink:NamedThing positive regulation of cell differentiation Any process that activates or increases the frequency, rate or extent of cell differentiation. got7fsn_ti stimulation of cell differentiation|up regulation of cell differentiation|upregulation of cell differentiation|activation of cell differentiation|up-regulation of cell differentiation biological_process owl:Class
GO:0120126 biolink:NamedThing response to copper ion starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of copper ion. got7fsn_ti krc 2018-02-12T19:49:19Z biological_process owl:Class
GO:0072426 biolink:NamedThing response to G2 DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling. got7fsn_ti response to signal involved in G2/M transition DNA damage checkpoint|G2/M transition DNA damage checkpoint effector process mah 2010-12-08T04:26:35Z biological_process owl:Class
GO:0072423 biolink:NamedThing response to DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling. got7fsn_ti response to signal involved in DNA damage checkpoint|DNA damage checkpoint effector process mah 2010-12-08T04:20:25Z biological_process owl:Class
GO:0002363 biolink:NamedThing alpha-beta T cell lineage commitment The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell. got7fsn_ti alpha-beta T-lymphocyte lineage commitment|alpha-beta T-cell lineage commitment|alpha-beta T lymphocyte lineage commitment biological_process owl:Class
GO:0002360 biolink:NamedThing T cell lineage commitment The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell. got7fsn_ti T-cell lineage commitment|T lymphocyte lineage commitment|T-lymphocyte lineage commitment biological_process owl:Class
GO:0000418 biolink:NamedThing RNA polymerase IV complex RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex. got7fsn_ti DNA-directed RNA polymerase IV complex|DNA-directed RNA polymerase IVa complex GO:0000420 cellular_component owl:Class
GO:0000378 biolink:NamedThing RNA exon ligation The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction. got7fsn_ti Note that this is not a part of spliceosomal RNA splicing. biological_process owl:Class
GO:0016070 biolink:NamedThing RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. got7fsn_ti RNA metabolism biological_process owl:Class
GO:1990671 biolink:NamedThing vesicle fusion with Golgi medial cisterna membrane The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles. got7fsn_ti bhm 2015-03-02T11:31:01Z biological_process owl:Class
GO:0048280 biolink:NamedThing vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. got7fsn_ti biological_process owl:Class
GO:1990203 biolink:NamedThing MdtBC Complex A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane. got7fsn_ti multidrug efflux pump MdtBC bhm 2013-10-04T21:22:18Z cellular_component owl:Class
GO:1902495 biolink:NamedThing transmembrane transporter complex A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. got7fsn_ti bhm 2013-11-13T16:23:04Z cellular_component owl:Class
GO:0102099 biolink:NamedThing FAD-dependent urate hydroxylase activity Catalysis of the reaction: 7,9-dihydro-1H-purine-2,6,8(3H)-trione + NADH + H+ + O2 <=> 5-hydroxyisouric acid + NAD + H2O. got7fsn_ti RHEA:27329|MetaCyc:RXN-11186|EC:1.14.13.113 molecular_function owl:Class
GO:0099514 biolink:NamedThing synaptic vesicle cytoskeletal transport The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. got7fsn_ti biological_process owl:Class
GO:0030705 biolink:NamedThing cytoskeleton-dependent intracellular transport The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell. got7fsn_ti biological_process owl:Class
GO:0033583 biolink:NamedThing rhabdomere membrane The portion of the plasma membrane surrounding the rhabdomere. got7fsn_ti cellular_component owl:Class
GO:0047628 biolink:NamedThing ADP-thymidine kinase activity Catalysis of the reaction: ADP + thymidine = AMP + thymidine 5'-phosphate. got7fsn_ti adenosine diphosphate-thymidine phosphotransferase activity|ADP:dThd phosphotransferase activity|ADP:thymidine 5'-phosphotransferase activity RHEA:13413|EC:2.7.1.118|MetaCyc:ADP--THYMIDINE-KINASE-RXN molecular_function owl:Class
GO:0048904 biolink:NamedThing anterior lateral line neuromast cupula development The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. got7fsn_ti biological_process owl:Class
GO:0048887 biolink:NamedThing cupula development The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. got7fsn_ti biological_process owl:Class
GO:0009399 biolink:NamedThing nitrogen fixation The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide. got7fsn_ti MetaCyc:N2FIX-PWY|Wikipedia:Nitrogen_fixation biological_process owl:Class
GO:0072255 biolink:NamedThing metanephric glomerular mesangial cell development The process whose specific outcome is the progression of a glomerular mesangial cell in the metanephros over time, from its formation to the mature structure. got7fsn_ti mah 2010-03-19T04:06:58Z biological_process owl:Class
GO:0052128 biolink:NamedThing positive energy taxis The directed movement of a motile cell or organism towards a higher level of a physical stimulus involved in energy generation, such as light, oxygen, and oxidizable substrates. got7fsn_ti biological_process owl:Class
GO:0006019 biolink:NamedThing deoxyribose 5-phosphate phosphorylation The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate. got7fsn_ti biological_process owl:Class
GO:0046389 biolink:NamedThing deoxyribose 5-phosphate metabolic process The chemical reactions and pathways involving deoxyribose 5-phosphate, the phosphorylated sugar 5-phospho-2-deoxyribose. got7fsn_ti deoxyribose 5-phosphate metabolism biological_process owl:Class
GO:0044727 biolink:NamedThing DNA demethylation of male pronucleus The active DNA demethylation of the paternal genome that takes place before the first cell division. got7fsn_ti jl 2012-10-24T14:25:35Z biological_process owl:Class
GO:0043045 biolink:NamedThing DNA methylation involved in embryo development The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression. got7fsn_ti de novo DNA methylation biological_process owl:Class
GO:0051783 biolink:NamedThing regulation of nuclear division Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. got7fsn_ti biological_process owl:Class
GO:0001888 biolink:NamedThing glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan. got7fsn_ti UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity|alpha-1,4-N-acetylglucosaminyltransferase activity|glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|alpha-N-acetylglucosaminyltransferase I activity|UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity|alpha1,4-N-acetylglucosaminyltransferase activity RHEA:16221|MetaCyc:2.4.1.223-RXN|EC:2.4.1.223 molecular_function owl:Class
GO:0102272 biolink:NamedThing homophytochelatin synthase activity (polymer-forming) Catalysis of the reaction: glutathionate + a poly gamma-glutamylcysteine-beta-alanine = glycine + a poly gamma-glutamylcysteine-beta-alanine. got7fsn_ti MetaCyc:RXN-12528 molecular_function owl:Class
GO:0071223 biolink:NamedThing cellular response to lipoteichoic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. got7fsn_ti cellular response to LTA mah 2009-12-03T01:31:00Z biological_process owl:Class
GO:0061110 biolink:NamedThing dense core granule biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a dense core granule. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the dense core granule. got7fsn_ti dph 2010-05-01T09:40:11Z biological_process owl:Class
GO:0044085 biolink:NamedThing cellular component biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. got7fsn_ti cellular component biogenesis at cellular level GO:0071843 biological_process owl:Class
GO:0019956 biolink:NamedThing chemokine binding Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. got7fsn_ti molecular_function owl:Class
GO:0007507 biolink:NamedThing heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. got7fsn_ti cardiac development|dorsal vessel development GO:0007511 Wikipedia:Heart_development biological_process owl:Class
GO:0002950 biolink:NamedThing ceramide phosphoethanolamine synthase activity Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine. got7fsn_ti hjd 2016-08-16T13:41:21Z Reactome:R-HSA-8959462 molecular_function owl:Class
GO:0070198 biolink:NamedThing protein localization to chromosome, telomeric region Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome. got7fsn_ti protein localisation to chromosome, telomeric region|protein localization to telomere biological_process owl:Class
GO:0042746 biolink:NamedThing circadian sleep/wake cycle, wakefulness The part of the circadian sleep/wake cycle where the organism is not asleep. got7fsn_ti biological_process owl:Class
GO:0022410 biolink:NamedThing circadian sleep/wake cycle process A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm. got7fsn_ti biological_process owl:Class
GO:0048327 biolink:NamedThing axial mesodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti axial mesoderm cell fate specification biological_process owl:Class
GO:0007501 biolink:NamedThing mesodermal cell fate specification The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti mesoderm cell fate specification Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'. biological_process owl:Class
GO:0061968 biolink:NamedThing maintenance of left/right asymmetry The organization process that preserves the asymmetry in an organism's body plan or part of an organism with respect to the left and right halves. got7fsn_ti dph 2018-02-12T16:38:47Z biological_process owl:Class
GO:0051678 biolink:NamedThing pullulan catabolic process The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. got7fsn_ti biological_process owl:Class
GO:0047246 biolink:NamedThing luteolin-7-O-glucuronide 7-O-glucuronosyltransferase activity Catalysis of the reaction: luteolin 7-O-beta-D-glucosiduronate + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP. got7fsn_ti uridine diphosphoglucuronate-luteolin 7-O-glucuronide glucuronosyltransferase activity|luteolin-7-O-glucuronide 2''-O-glucuronosyltransferase activity|LMT activity|UDP-glucuronate:luteolin-7-O-beta-D-glucuronide 2''-O-glucuronosyltransferase activity|UDP-glucuronate:luteolin 7-O-glucuronide-glucuronosyltransferase activity EC:2.4.1.190|KEGG_REACTION:R06827|MetaCyc:2.4.1.190-RXN|RHEA:14149 molecular_function owl:Class
GO:0015020 biolink:NamedThing glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. got7fsn_ti UDP-glucuronyltransferase activity|uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|phenyl-UDP-glucuronosyltransferase activity|UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity|UDP glucuronyltransferase activity|1-naphthol glucuronyltransferase activity|3alpha-hydroxysteroid UDP-glucuronosyltransferase activity|bilirubin UDPGT activity|UDP-glucuronosyltransferase activity|GT activity|uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity|uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity|UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)|17-beta-hydroxysteroid UDP-glucuronosyltransferase activity|bilirubin uridine diphosphoglucuronyltransferase activity|p-nitrophenol UDP-glucuronosyltransferase activity|uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity|PNP-UDPGT|ciramadol UDP-glucuronyltransferase activity|bilirubin UDP-glucuronosyltransferase activity|uridine diphosphate glucuronyltransferase activity|4-nitrophenol UDP-glucuronyltransferase activity|uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity|UDP glucuronic acid transferase activity|17-OH steroid UDPGT activity|p-hydroxybiphenyl UDP glucuronyltransferase activity|3-OH androgenic UDPGT activity|uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity|4-methylumbelliferone UDP-glucuronosyltransferase activity|UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity|uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity|UDP glucuronate-estriol glucuronosyltransferase activity|17beta-hydroxysteroid UDP-glucuronosyltransferase activity|1-naphthol-UDP-glucuronosyltransferase activity|3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity|4-nitrophenol UDPGT activity|p-nitrophenol UDP-glucuronyltransferase activity|4-hydroxybiphenyl UDP-glucuronosyltransferase activity|UDP glucuronate-estradiol-glucuronosyltransferase activity|UDPGT activity|UDP-glucuronate-bilirubin glucuronyltransferase activity|uridine diphosphoglucuronate-estriol glucuronosyltransferase activity|bilirubin monoglucuronide glucuronyltransferase activity|UDPGA-glucuronyltransferase activity|p-phenylphenol glucuronyltransferase activity|estriol UDPglucuronosyltransferase activity|estrone UDPglucuronosyltransferase activity|morphine glucuronyltransferase activity|bilirubin glucuronyltransferase activity|pnp-UDPGT activity|p-nitrophenylglucuronosyltransferase activity|uridine 5'-diphosphoglucuronyltransferase activity|UDPGA transferase activity|uridine diphosphoglucuronyltransferase activity|uridine diphosphoglucuronosyltransferase activity|UDP glucuronosyltransferase activity GO:0003981 Reactome:R-HSA-9036102|Reactome:R-HSA-159179|RHEA:21032|Reactome:R-HSA-5604954|Reactome:R-HSA-5604975|Reactome:R-HSA-159194|Reactome:R-HSA-9036104|Reactome:R-HSA-5617143|MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN|Reactome:R-HSA-174931|Reactome:R-HSA-9638097|Reactome:R-HSA-174916|Reactome:R-HSA-2162099|Reactome:R-HSA-9632038|Reactome:R-HSA-8941701|Reactome:R-HSA-9632039|EC:2.4.1.17 molecular_function owl:Class
GO:0070167 biolink:NamedThing regulation of biomineral tissue development Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. got7fsn_ti biological_process owl:Class
GO:0060349 biolink:NamedThing bone morphogenesis The process in which bones are generated and organized. got7fsn_ti biological_process owl:Class
GO:0004160 biolink:NamedThing dihydroxy-acid dehydratase activity Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. got7fsn_ti dihydroxy acid dehydrase activity|DHAD|alpha,beta-dihydroxyisovalerate dehydratase activity|2,3-dihydroxyisovalerate dehydratase activity|acetohydroxyacid dehydratase activity|alpha,beta-dihydroxyacid dehydratase activity|2,3-dihydroxy-acid hydro-lyase activity|2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming) MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN|EC:4.2.1.9|RHEA:20936 molecular_function owl:Class
GO:0030832 biolink:NamedThing regulation of actin filament length Any process that controls the length of actin filaments in a cell. got7fsn_ti Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:0032956 biolink:NamedThing regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. got7fsn_ti regulation of actin cytoskeleton organisation|regulation of actin cytoskeleton organization and biogenesis biological_process owl:Class
GO:0009081 biolink:NamedThing branched-chain amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. got7fsn_ti branched chain family amino acid metabolism biological_process owl:Class
GO:0018147 biolink:NamedThing molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide). got7fsn_ti RESID:AA0248 biological_process owl:Class
GO:0050844 biolink:NamedThing peptidyl-selenocysteine modification The modification of peptidyl-selenocysteine. got7fsn_ti biological_process owl:Class
GO:0018938 biolink:NamedThing 2-nitropropane metabolic process The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol. got7fsn_ti 2-nitropropane metabolism MetaCyc:PWY-723|UM-BBD_pathwayID:npp biological_process owl:Class
GO:0044684 biolink:NamedThing dihydromethanopterin reductase activity Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP. got7fsn_ti jl 2012-08-15T13:57:55Z RHEA:42804|EC:1.5.99.15 molecular_function owl:Class
GO:0043808 biolink:NamedThing lyso-ornithine lipid acyltransferase activity Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]. got7fsn_ti molecular_function owl:Class
GO:0001640 biolink:NamedThing adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. got7fsn_ti adenylyl cyclase inhibiting metabotropic glutamate receptor activity|adenylate cyclase inhibiting metabotropic glutamate receptor activity molecular_function owl:Class
GO:0008066 biolink:NamedThing glutamate receptor activity Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0018077 biolink:NamedThing protein iodination The addition of one or more iodine atoms to an amino acid residue in a protein. got7fsn_ti protein amino acid iodination biological_process owl:Class
GO:0004793 biolink:NamedThing threonine aldolase activity Catalysis of the reaction: L-threonine = glycine + acetaldehyde. got7fsn_ti L-threonine acetaldehyde-lyase (glycine-forming)|L-threonine acetaldehyde-lyase activity|L-threonine aldolase activity EC:4.1.2.5|MetaCyc:THREONINE-ALDOLASE-RXN|RHEA:19625 molecular_function owl:Class
GO:0006304 biolink:NamedThing DNA modification The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. got7fsn_ti biological_process owl:Class
GO:0080004 biolink:NamedThing thalian-diol desaturase activity Catalysis of the reaction: a thalian-diol = a desaturated thalian-diol. This reaction is the introduction of a double bond to a thalian-diol molecule at carbon 15. got7fsn_ti EC:1.14.21.-|MetaCyc:RXN-9637 molecular_function owl:Class
GO:0009022 biolink:NamedThing tRNA nucleotidyltransferase activity Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. got7fsn_ti RNase PH activity|tRNA:phosphate nucleotidyltransferase activity|phosphate-dependent exonuclease activity|ribonuclease PH activity Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN|RHEA:10628|EC:2.7.7.56 molecular_function owl:Class
GO:0030334 biolink:NamedThing regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration. got7fsn_ti biological_process owl:Class
GO:0046199 biolink:NamedThing cresol catabolic process The chemical reactions and pathways resulting in the breakdown of cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote. got7fsn_ti cresol degradation|cresol breakdown|cresol catabolism biological_process owl:Class
GO:0102780 biolink:NamedThing sitosterol hydroxylase activity Catalysis of the reaction: H+ + sitosterol + O2 + NADPH <=> (22alpha)-hydroxy-sitosterol + H2O + NADP. got7fsn_ti MetaCyc:RXN-7876 molecular_function owl:Class
GO:0008797 biolink:NamedThing aspartate ammonia-lyase activity Catalysis of the reaction: L-aspartate = fumarate + NH3. got7fsn_ti L-aspartase activity|L-aspartate ammonia-lyase activity|aspartase activity|L-aspartate ammonia-lyase (fumarate-forming)|fumaric aminase activity RHEA:16601|EC:4.3.1.1|MetaCyc:ASPARTASE-RXN molecular_function owl:Class
GO:0019834 biolink:NamedThing phospholipase A2 inhibitor activity Binds to and stops, prevents or reduces the activity of phospholipase A2. got7fsn_ti molecular_function owl:Class
GO:0050601 biolink:NamedThing myristoyl-CoA 11-(Z) desaturase activity Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O. got7fsn_ti Z/E11-desaturase|fatty acid delta(11)-desaturase|delta(11)-palmitoyl-CoA desaturase|delta(11)-fatty-acid desaturase|delta(11) desaturase MetaCyc:1.14.99.32-RXN|RHEA:25852|EC:1.14.19.5 molecular_function owl:Class
GO:0009007 biolink:NamedThing site-specific DNA-methyltransferase (adenine-specific) activity Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. got7fsn_ti N-6 adenine-specific DNA methylase activity|EcoRI methylase|DNA adenine methylase|restriction-modification system activity|modification methylase activity EC:2.1.1.72|MetaCyc:2.1.1.72-RXN|RHEA:15197 molecular_function owl:Class
GO:0048139 biolink:NamedThing female germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the female gonad. got7fsn_ti biological_process owl:Class
GO:0048138 biolink:NamedThing germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst. got7fsn_ti biological_process owl:Class
GO:0044631 biolink:NamedThing positive regulation of complement activation, lectin pathway in other organism Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism. got7fsn_ti jl 2012-07-05T01:17:33Z biological_process owl:Class
GO:0001870 biolink:NamedThing positive regulation of complement activation, lectin pathway Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway. got7fsn_ti upregulation of complement activation, lectin pathway|stimulation of complement activation, lectin pathway|activation of complement activation, lectin pathway|up regulation of complement activation, lectin pathway|positive regulation of complement cascade, lectin pathway|up-regulation of complement activation, lectin pathway biological_process owl:Class
GO:0060843 biolink:NamedThing venous endothelial cell differentiation The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins. got7fsn_ti dph 2009-08-12T10:43:40Z biological_process owl:Class
GO:0072324 biolink:NamedThing ascus epiplasm Ascus cytoplasm that is not packaged into ascospores. got7fsn_ti Note that this term is an is_a child of 'cell part' because the epiplasm is extracellular to the spore (each of which is a cell) but within the ascus structure, and originated from cytoplasm. mah 2010-10-28T04:37:46Z cellular_component owl:Class
GO:0007383 biolink:NamedThing specification of segmental identity, antennal segment The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'. biological_process owl:Class
GO:0007380 biolink:NamedThing specification of segmental identity, head The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0009302 biolink:NamedThing sno(s)RNA transcription The synthesis of snoRNA class RNA (also referred to as sRNA in Archaea) from a DNA template. got7fsn_ti sRNA transcription|snoRNA transcription https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0008301 biolink:NamedThing DNA binding, bending The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. got7fsn_ti DNA bending involving DNA binding|DNA bending activity molecular_function owl:Class
GO:0032294 biolink:NamedThing peripheral nervous system non-myelinated axon ensheathment The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons. got7fsn_ti ensheathment of non-myelinated axons in peripheral nervous system biological_process owl:Class
GO:0032285 biolink:NamedThing non-myelinated axon ensheathment The process in which a non-myelinating glial cell membrane closes around an axon. got7fsn_ti ensheathment of non-myelinated axons biological_process owl:Class
GO:0044347 biolink:NamedThing cell wall polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides. got7fsn_ti cell wall polysaccharide breakdown jl 2011-07-28T01:24:57Z biological_process owl:Class
GO:0016998 biolink:NamedThing cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. got7fsn_ti cell wall breakdown|cell wall catabolism|cellular cell wall macromolecule degradation|cellular cell wall macromolecule catabolic process|cellular cell wall macromolecule breakdown|cell wall degradation|cellular cell wall macromolecule catabolism GO:0044039 biological_process owl:Class
GO:0061516 biolink:NamedThing monocyte proliferation The expansion of a monocyte population by cell division. got7fsn_ti dph 2013-04-18T13:14:24Z biological_process owl:Class
GO:0004797 biolink:NamedThing thymidine kinase activity Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. got7fsn_ti ATP:thymidine 5'-phosphotransferase activity|2'-deoxythymidine kinase activity|deoxythymidine kinase (phosphorylating)|thymidine kinase (phosphorylating) EC:2.7.1.21|MetaCyc:THYKI-RXN|RHEA:19129 molecular_function owl:Class
GO:0044383 biolink:NamedThing host chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell. got7fsn_ti jl 2011-12-13T03:58:38Z cellular_component owl:Class
GO:0033647 biolink:NamedThing host intracellular organelle Organized structure of distinctive morphology and function, occurring within the host cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cellular_component owl:Class
GO:0090632 biolink:NamedThing N-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity Catalysis of the reaction: CTP + Neu5Gc = diphosphate + CMP-Neu5Gc. got7fsn_ti CMP-Neu5Gc synthetase activity tb 2015-03-19T15:05:54Z molecular_function owl:Class
GO:0061685 biolink:NamedThing diphthine methylesterase activity Catalysis of the reaction: diphthine methyl ester + H2O <=> diphthine + H+ + methanol. got7fsn_ti dph 2015-03-04T16:00:21Z EC:3.1.1.97|RHEA:42656 molecular_function owl:Class
GO:0001680 biolink:NamedThing tRNA 3'-terminal CCA addition Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition. got7fsn_ti CCA tRNA nucleotidyltransferase activity|transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity|tRNA adenylyl(cytidylyl)transferase activity|CTP:tRNA cytidylyltransferase activity|ATP(CTP):tRNA nucleotidyltransferase activity|transfer ribonucleic adenylyl (cytidylyl) transferase activity|transfer ribonucleate nucleotidyltransferase activity|ribonucleic cytidylyltransferase activity|ATP(CTP)-tRNA nucleotidyltransferase activity|-C-C-A pyrophosphorylase activity|CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity|CCA-adding enzyme activity|transfer ribonucleate adenylyltransferase activity|transfer ribonucleate adenyltransferase activity|ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity|tRNA cytidylyltransferase activity|CTP(ATP):tRNA nucleotidyltransferase activity|transfer ribonucleate cytidylyltransferase activity|transfer-RNA nucleotidyltransferase activity|transfer ribonucleic acid nucleotidyl transferase activity|tRNA-nucleotidyltransferase activity|transfer RNA adenylyltransferase activity|tRNA CCA-diphosphorylase activity MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN|KEGG_REACTION:R09382 biological_process owl:Class
GO:0042780 biolink:NamedThing tRNA 3'-end processing The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA. got7fsn_ti tRNA 3' processing biological_process owl:Class
GO:0017096 biolink:NamedThing acetylserotonin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine. got7fsn_ti hydroxyindole methyltransferase activity|acetylserotonin methyltransferase activity|N-acetylserotonin O-methyltransferase activity|hydroxyindole O-methyltransferase activity|S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity GO:0017097 MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN|RHEA:15573|EC:2.1.1.4 molecular_function owl:Class
GO:0097667 biolink:NamedThing SCF-Rcy1/Pof6 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe). got7fsn_ti pr 2014-10-06T10:28:09Z cellular_component owl:Class
GO:0102170 biolink:NamedThing 5-epi-aristolochene-1,3-dihydroxylase activity Catalysis of the reaction: (+)-5-epi-aristolochene + 2 NADPH + 2 H+ + 2 O2 <=> capsidiol + 2 NADP + 2 H2O. got7fsn_ti RHEA:28226|MetaCyc:RXN-11908|EC:1.14.14.149 molecular_function owl:Class
GO:0030157 biolink:NamedThing pancreatic juice secretion The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach. got7fsn_ti biological_process owl:Class
GO:0050972 biolink:NamedThing detection of mechanical stimulus involved in echolocation The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave. got7fsn_ti echolocation, sensory detection of mechanical stimulus|sensory detection of mechanical stimulus during echolocation|echolocation, detection of mechanical stimulus|echolocation, sensory transduction of mechanical stimulus|sensory transduction of mechanical stimulus during echolocation biological_process owl:Class
GO:0010635 biolink:NamedThing regulation of mitochondrial fusion Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. got7fsn_ti biological_process owl:Class
GO:0071744 biolink:NamedThing IgE B cell receptor complex An IgE immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti membrane-bound IgE|surface IgE Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0050728 biolink:NamedThing negative regulation of inflammatory response Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. got7fsn_ti inhibition of inflammatory response|anti-inflammatory response|down-regulation of inflammatory response|down regulation of inflammatory response|downregulation of inflammatory response GO:0030236 biological_process owl:Class
GO:0031348 biolink:NamedThing negative regulation of defense response Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response. got7fsn_ti down regulation of defense response|down-regulation of defense response|inhibition of defense response|downregulation of defense response biological_process owl:Class
GO:0042902 biolink:NamedThing peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan. got7fsn_ti RESID:AA0345 biological_process owl:Class
GO:0009033 biolink:NamedThing trimethylamine-N-oxide reductase activity Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O. got7fsn_ti trimethylamine oxidase activity|trimethylamine N-oxide reductase|trimethylamine oxide reductase|NADH:trimethylamine-N-oxide oxidoreductase RHEA:22024|MetaCyc:TMAOREDUCT-RXN molecular_function owl:Class
GO:0070295 biolink:NamedThing renal water absorption A renal system process in which water is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. got7fsn_ti renal water reabsorption|nephron water absorption biological_process owl:Class
GO:0003097 biolink:NamedThing renal water transport The directed movement of water (H2O) by the renal system. got7fsn_ti biological_process owl:Class
GO:1904319 biolink:NamedThing negative regulation of smooth muscle contraction involved in micturition Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition. got7fsn_ti down-regulation of urinary bladder smooth muscle contraction involved in micturition|down regulation of urinary bladder smooth muscle contraction involved in micturition|down-regulation of smooth muscle contraction involved in micturition|inhibition of smooth muscle contraction involved in urination|negative regulation of urinary bladder smooth muscle contraction involved in micturition|down regulation of smooth muscle contraction involved in micturition|downregulation of smooth muscle contraction involved in urination|down regulation of smooth muscle contraction involved in urination|down-regulation of smooth muscle contraction involved in urination|negative regulation of smooth muscle contraction involved in urination|inhibition of urinary bladder smooth muscle contraction involved in micturition|downregulation of urinary bladder smooth muscle contraction involved in micturition|inhibition of smooth muscle contraction involved in micturition|downregulation of smooth muscle contraction involved in micturition sl 2015-06-10T18:46:17Z biological_process owl:Class
GO:0008098 biolink:NamedThing 5S rRNA primary transcript binding Binding to an unprocessed 5S ribosomal RNA transcript. got7fsn_ti molecular_function owl:Class
GO:0008097 biolink:NamedThing 5S rRNA binding Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. got7fsn_ti molecular_function owl:Class
GO:0050505 biolink:NamedThing hydroquinone glucosyltransferase activity Catalysis of the reaction: hydroquinone + UDP-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP. got7fsn_ti UDPglucose:hydroquinone-O-beta-D-glucosyltransferase activity|hydroquinone:O-glucosyltransferase activity|UDP-glucose:hydroquinone-O-beta-D-glucosyltransferase activity|arbutin synthase activity RHEA:12560|KEGG_REACTION:R05769|MetaCyc:2.4.1.218-RXN|EC:2.4.1.218 molecular_function owl:Class
GO:0061239 biolink:NamedThing mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti dph 2010-08-19T03:06:46Z biological_process owl:Class
GO:0072037 biolink:NamedThing mesenchymal stem cell differentiation involved in nephron morphogenesis The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephron. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti mah 2010-01-25T03:07:39Z biological_process owl:Class
GO:0007253 biolink:NamedThing cytoplasmic sequestering of NF-kappaB The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus. got7fsn_ti maintenance of NF-kappaB location in cytoplasm|cytoplasmic NF-kappaB sequestration|cytoplasmic NF-kappaB retention|cytoplasmic retention of NF-kappaB|cytoplasmic sequestration of NF-kappaB|cytoplasmic NF-kappaB storage|cytoplasmic storage of NF-kappaB biological_process owl:Class
GO:0032088 biolink:NamedThing negative regulation of NF-kappaB transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. got7fsn_ti inhibition of NF-kappaB transcription factor|NF-kappaB inhibitor biological_process owl:Class
GO:0001878 biolink:NamedThing response to yeast Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species. got7fsn_ti defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. biological_process owl:Class
GO:0030224 biolink:NamedThing monocyte differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. got7fsn_ti monocyte cell differentiation biological_process owl:Class
GO:0019241 biolink:NamedThing citrulline catabolic process The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins. got7fsn_ti citrulline degradation|citrulline catabolism|citrulline breakdown MetaCyc:CITRULLINE-DEG-PWY biological_process owl:Class
GO:0032881 biolink:NamedThing regulation of polysaccharide metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides. got7fsn_ti biological_process owl:Class
GO:0002275 biolink:NamedThing myeloid cell activation involved in immune response A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. got7fsn_ti myeloid cell activation during immune response biological_process owl:Class
GO:0002366 biolink:NamedThing leukocyte activation involved in immune response A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. got7fsn_ti immune cell activation during immune response|leucocyte activation during immune response|leukocyte activation during immune response biological_process owl:Class
GO:0044806 biolink:NamedThing G-quadruplex DNA unwinding The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'. got7fsn_ti jl 2013-09-10T16:16:16Z biological_process owl:Class
GO:0032392 biolink:NamedThing DNA geometric change The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases. got7fsn_ti Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo. biological_process owl:Class
GO:0017108 biolink:NamedThing 5'-flap endonuclease activity Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. got7fsn_ti 5' flap endonuclease activity Reactome:R-HSA-110363|Reactome:R-HSA-5687664|Reactome:R-HSA-174441|Reactome:R-HSA-174446|Reactome:R-HSA-69152|Reactome:R-HSA-5651782 molecular_function owl:Class
GO:0044553 biolink:NamedThing modulation of biological quality in other organism Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. got7fsn_ti regulation of biological quality in other organism jl 2012-03-29T02:35:03Z biological_process owl:Class
GO:1903489 biolink:NamedThing positive regulation of lactation Any process that activates or increases the frequency, rate or extent of lactation. got7fsn_ti up-regulation of lactation|up regulation of lactation|upregulation of lactation|activation of lactation mr 2014-09-24T14:44:30Z biological_process owl:Class
GO:1903487 biolink:NamedThing regulation of lactation Any process that modulates the frequency, rate or extent of lactation. got7fsn_ti mr 2014-09-24T14:44:13Z biological_process owl:Class
GO:0018032 biolink:NamedThing protein amidation Addition of an amide group from a glycine to a protein amino acid. got7fsn_ti protein amino acid amidation biological_process owl:Class
GO:0050654 biolink:NamedThing chondroitin sulfate proteoglycan metabolic process The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. got7fsn_ti chondroitin sulfate proteoglycan metabolism|chondroitin sulphate proteoglycan metabolic process|chondroitin sulphate proteoglycan metabolism biological_process owl:Class
GO:0006029 biolink:NamedThing proteoglycan metabolic process The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. got7fsn_ti proteoglycan sulfate transfer|proteoglycan metabolism biological_process owl:Class
GO:0097462 biolink:NamedThing Lewy neurite Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease. got7fsn_ti pr 2012-12-21T07:57:58Z NIF_Subcellular:sao601362597 cellular_component owl:Class
GO:0051111 biolink:NamedThing peptidyl-histidine adenylylation The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine). got7fsn_ti RESID:AA0371 biological_process owl:Class
GO:1903055 biolink:NamedThing positive regulation of extracellular matrix organization Any process that activates or increases the frequency, rate or extent of extracellular matrix organization. got7fsn_ti up-regulation of extracellular matrix organisation|activation of extracellular matrix organization|up regulation of extracellular matrix organisation|up regulation of extracellular matrix organization|up regulation of extracellular matrix organization and biogenesis|activation of extracellular matrix organisation|upregulation of extracellular matrix organization|up-regulation of extracellular matrix organization|upregulation of extracellular matrix organisation|positive regulation of extracellular matrix organisation|positive regulation of extracellular matrix organization and biogenesis|up-regulation of extracellular matrix organization and biogenesis|activation of extracellular matrix organization and biogenesis|upregulation of extracellular matrix organization and biogenesis rl 2014-05-23T17:15:53Z biological_process owl:Class
GO:0090439 biolink:NamedThing tetraketide alpha-pyrone synthase activity Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A . got7fsn_ti tb 2012-08-09T14:35:06Z molecular_function owl:Class
GO:0002464 biolink:NamedThing peripheral tolerance induction to nonself antigen Tolerance induction to nonself antigens in the periphery. got7fsn_ti biological_process owl:Class
GO:0002462 biolink:NamedThing tolerance induction to nonself antigen Tolerance induction in response to nonself antigens. got7fsn_ti biological_process owl:Class
GO:0018850 biolink:NamedThing chloromuconate cycloisomerase activity Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate. got7fsn_ti 2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)|muconate cycloisomerase II activity RHEA:11032|EC:5.5.1.7|UM-BBD_enzymeID:e0065 molecular_function owl:Class
GO:0004075 biolink:NamedThing biotin carboxylase activity Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. got7fsn_ti biotin carboxylase (component of acetyl CoA carboxylase) activity|biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity EC:6.3.4.14|RHEA:13501|MetaCyc:BIOTIN-CARBOXYL-RXN molecular_function owl:Class
GO:0043110 biolink:NamedThing rDNA spacer replication fork barrier binding Binding to replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription. got7fsn_ti RFB binding molecular_function owl:Class
GO:0031634 biolink:NamedThing replication fork barrier binding Binding to replication fork barriers, sites that inhibit the progress of replication forks. got7fsn_ti molecular_function owl:Class
GO:0055067 biolink:NamedThing monovalent inorganic cation homeostasis Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0018245 biolink:NamedThing protein O-linked glycosylation via tyrosine The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen. got7fsn_ti protein amino acid O-linked glycosylation via tyrosine RESID:AA0157 biological_process owl:Class
GO:0033855 biolink:NamedThing nicotianamine aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + nicotianamine = 3''-deamino-3''-oxonicotianamine + L-glutamate. got7fsn_ti NAAT-III|NAAT|NAAT-I|NAAT-II|nicotianamine:2-oxoglutarate aminotransferase activity|nicotianamine transaminase activity KEGG_REACTION:R07277|RHEA:22104|MetaCyc:2.6.1.80-RXN|EC:2.6.1.80 molecular_function owl:Class
GO:0072517 biolink:NamedThing host cell viral assembly compartment A membrane-bounded compartment that forms in the cytoplasm of the host cell, in which virus assembly takes place. got7fsn_ti virion assembly compartment|viral assembly site|host cell virion assembly compartment|host cell viral assembly site|viral assembly compartment mah 2010-12-21T03:08:42Z GO:0072516 cellular_component owl:Class
GO:0035847 biolink:NamedThing uterine epithelium development The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. got7fsn_ti uterus epithelial development bf 2011-05-10T10:57:45Z biological_process owl:Class
GO:0016822 biolink:NamedThing hydrolase activity, acting on acid carbon-carbon bonds Catalysis of the hydrolysis of any acid carbon-carbon bond. got7fsn_ti EC:3.7.-.- molecular_function owl:Class
GO:0005725 biolink:NamedThing intercalary heterochromatin Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes. got7fsn_ti cellular_component owl:Class
GO:0000792 biolink:NamedThing heterochromatin A compact and highly condensed form of chromatin. got7fsn_ti nuclear heterochromatin GO:0005720 Wikipedia:Heterochromatin|NIF_Subcellular:sao581845896 cellular_component owl:Class
GO:0038130 biolink:NamedThing ERBB4 signaling pathway A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti receptor tyrosine-protein kinase erbB-4 signaling pathway|ERBB4 signalling pathway|HER4 signaling pathway bf 2012-03-30T10:44:08Z biological_process owl:Class
GO:0051364 biolink:NamedThing N-terminal peptidyl-proline N-formylation The formylation of the N-terminal proline of proteins to form the derivative N-formylproline. got7fsn_ti RESID:AA0384 biological_process owl:Class
GO:0031831 biolink:NamedThing type 5B serotonin receptor binding Binding to a type 5B serotonin receptor. got7fsn_ti type 5B serotonin receptor ligand|5-hydroxytryptamine 5B receptor binding molecular_function owl:Class
GO:0014862 biolink:NamedThing regulation of skeletal muscle contraction by chemo-mechanical energy conversion Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres. got7fsn_ti biological_process owl:Class
GO:0014819 biolink:NamedThing regulation of skeletal muscle contraction Any process that modulates the frequency, rate or extent of skeletal muscle contraction. got7fsn_ti biological_process owl:Class
GO:0035665 biolink:NamedThing TIRAP-dependent toll-like receptor 4 signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. got7fsn_ti TIRAP-dependent TLR4 signaling pathway|MAL-dependent toll-like receptor 4 signaling pathway|MyD88 adapter-like dependent toll-like receptor 4 signaling pathway|TIRAP-dependent toll-like receptor 4 signalling pathway bf 2011-02-01T02:33:48Z biological_process owl:Class
GO:0051670 biolink:NamedThing inulinase activity Catalysis of the endohydrolysis of 2,1-beta-D-fructosidic linkages in inulin. got7fsn_ti exoinulinase activity|inulase activity|endo-inulinase activity|2,1-beta-D-fructan fructanohydrolase activity|indoinulinase activity EC:3.2.1.7|MetaCyc:3.2.1.7-RXN molecular_function owl:Class
GO:0051126 biolink:NamedThing negative regulation of actin nucleation Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. got7fsn_ti downregulation of actin nucleation|inhibition of actin nucleation|down regulation of actin nucleation|down-regulation of actin nucleation biological_process owl:Class
GO:0051494 biolink:NamedThing negative regulation of cytoskeleton organization Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures. got7fsn_ti down regulation of cytoskeleton organization|down-regulation of cytoskeleton organization|inhibition of cytoskeleton organization|negative regulation of cytoskeleton organization and biogenesis|negative regulation of cytoskeleton organisation|downregulation of cytoskeleton organization biological_process owl:Class
GO:0034408 biolink:NamedThing ascospore wall beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores. got7fsn_ti ascospore wall beta-glucan metabolism biological_process owl:Class
GO:0070879 biolink:NamedThing fungal-type cell wall beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. got7fsn_ti fungal-type cell wall beta-glucan metabolism mah 2009-08-21T02:46:09Z biological_process owl:Class
GO:0018067 biolink:NamedThing peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA). got7fsn_ti peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine|peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine|peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine RESID:AA0146 biological_process owl:Class
GO:0035369 biolink:NamedThing pre-B cell receptor complex An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti pre-BCR Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome. bf 2010-03-11T10:46:10Z cellular_component owl:Class
GO:0050802 biolink:NamedThing circadian sleep/wake cycle, sleep The part of the circadian sleep/wake cycle where the organism is asleep. got7fsn_ti biological_process owl:Class
GO:0097003 biolink:NamedThing adipokinetic hormone receptor activity Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. got7fsn_ti AKH receptor activity pr 2011-03-14T10:24:08Z molecular_function owl:Class
GO:0080015 biolink:NamedThing sabinene synthase activity Catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate. got7fsn_ti MetaCyc:RXN-5103|EC:4.2.3.- molecular_function owl:Class
GO:0080178 biolink:NamedThing 5-carbamoylmethyl uridine residue modification The chemical reactions and pathways involving the addition of a 5-carbamoylmethyl group to a uridine residue in RNA. got7fsn_ti 5-carbamoylmethyluridine metabolic process dhl 2011-04-28T04:36:23Z biological_process owl:Class
GO:0043174 biolink:NamedThing nucleoside salvage Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0007443 biolink:NamedThing Malpighian tubule morphogenesis The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut. got7fsn_ti See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'. biological_process owl:Class
GO:0061333 biolink:NamedThing renal tubule morphogenesis The process in which the renal tubule is generated by specification of cell fate, through the maintenance of cell polarity, regulated cell proliferation and morphogenetic cell rearrangements, shape changes and growth. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. got7fsn_ti dph 2010-09-28T01:43:04Z biological_process owl:Class
GO:0102782 biolink:NamedThing cholestanol hydroxylase activity Catalysis of the reaction: H+ + epidihydrocholesterin + O2 + NADPH = (22alpha)-hydroxy-cholestanol + H2O + NADP. got7fsn_ti MetaCyc:RXN-7878 molecular_function owl:Class
GO:0002870 biolink:NamedThing T cell anergy Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction. got7fsn_ti T lymphocyte anergy|T-lymphocyte anergy|T-cell anergy biological_process owl:Class
GO:0002249 biolink:NamedThing lymphocyte anergy Any process contributing to lymphocyte anergy, a state of functional inactivation. got7fsn_ti biological_process owl:Class
GO:0050484 biolink:NamedThing GMP 5'-nucleotidase activity Catalysis of the reaction: 5'-GMP + H2O = guanosine + phosphate. got7fsn_ti IMP-GMP specific 5'-nucleotidase activity|GMP 5' nucleotidase activity MetaCyc:RXN-7609|RHEA:27714 molecular_function owl:Class
GO:0008253 biolink:NamedThing 5'-nucleotidase activity Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. got7fsn_ti 5'-AMP nucleotidase|5'-ribonucleotide phosphohydrolase activity|adenosine monophosphatase|adenosine 5'-phosphatase|snake venom 5'-nucleotidase|5'-mononucleotidase activity|thimidine monophosphate nucleotidase|AMP phosphohydrolase|AMP phosphatase|5'-adenylic phosphatase|5' nucleotidase activity|AMPase|5'-AMPase|UMPase|uridine 5'-nucleotidase Reactome:R-HSA-8940074|Reactome:R-HSA-109480|MetaCyc:5-NUCLEOTID-RXN|Reactome:R-HSA-109380|Reactome:R-HSA-109415|Reactome:R-HSA-109387|Reactome:R-HSA-5694126|Reactome:R-HSA-109449|Reactome:R-HSA-109514|RHEA:12484|Reactome:R-HSA-74248|Reactome:R-HSA-109470|Reactome:R-HSA-8940070|EC:3.1.3.5|Reactome:R-HSA-109278|Reactome:R-HSA-109291 molecular_function owl:Class
GO:0001875 biolink:NamedThing lipopolysaccharide immune receptor activity Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. got7fsn_ti lipopolysaccharide receptor activity|endotoxin receptor activity|LPS receptor activity molecular_function owl:Class
GO:0038187 biolink:NamedThing pattern recognition receptor activity Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response. got7fsn_ti microbe-associated molecular pattern receptor activity|PAMP receptor activity|PRR activity|PRR|MAMP receptor activity|pathogen associated molecular pattern receptor activity|signaling pattern recognition receptor activity|macrophage receptor activity https://github.com/geneontology/go-ontology/issues/17995|https://github.com/geneontology/go-ontology/issues/18588 bf 2013-05-29T15:24:44Z GO:0008329 Wikipedia:Pattern_recognition_receptor molecular_function owl:Class
GO:0035749 biolink:NamedThing myelin sheath adaxonal region The region of the myelin sheath nearest to the axon. got7fsn_ti bf 2011-03-23T10:17:42Z cellular_component owl:Class
GO:0051938 biolink:NamedThing L-glutamate import The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle. got7fsn_ti L-glutamate uptake biological_process owl:Class
GO:0070029 biolink:NamedThing alphav-beta3 integrin-osteopontin complex A protein complex that consists of an alphav-beta3 integrin complex bound to osteopontin. got7fsn_ti ITGAV-ITGB3-SPP1 complex cellular_component owl:Class
GO:0002330 biolink:NamedThing pre-B cell receptor expression The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, starting with the recombination of an immunuglobulin heavy chain locus, including expression of the surrogate light chain, the association of the surrogate light chain with the heavy chain, and expression of the complete pre-B cell receptor on the cell surface. pre-B cell receptor expression is a key checkpoint in the transition of pro-B cell to pre-B cell. got7fsn_ti biological_process owl:Class
GO:0042613 biolink:NamedThing MHC class II protein complex A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen. got7fsn_ti cellular_component owl:Class
GO:0042611 biolink:NamedThing MHC protein complex A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. got7fsn_ti cellular_component owl:Class
GO:0009563 biolink:NamedThing synergid differentiation The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell. got7fsn_ti synergid cell differentiation biological_process owl:Class
GO:0070465 biolink:NamedThing alpha1-beta1 integrin-alpha3(VI) complex A protein complex that consists of an alpha1-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain. got7fsn_ti ITGA1-ITGB1-COL6A3 complex cellular_component owl:Class
GO:0048810 biolink:NamedThing female analia morphogenesis The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0070930 biolink:NamedThing trans-translation-dependent protein tagging A protein modification process in which a polypeptide is added to a nascent polypeptide cotranslationally by trans-translation. got7fsn_ti protein modification by trans-translation|cotranslational protein tagging|co-translational protein tagging Note that this term is not a child of 'co-translational protein modification process ; GO:0043686' because co-translational protein modification implies modification of a previously incorporated amino acid in a nascent chain, rather than addition of new sequence to the C-terminus. mah 2009-09-16T04:10:49Z biological_process owl:Class
GO:0018534 biolink:NamedThing nitrilotriacetate dehydrogenase activity Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate. got7fsn_ti EC:1.5.99.-|UM-BBD_reactionID:r0588 molecular_function owl:Class
GO:0018025 biolink:NamedThing calmodulin-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine. got7fsn_ti S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity|S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity|S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity EC:2.1.1.60|MetaCyc:2.1.1.60-RXN|Reactome:R-HSA-6786205|RHEA:21556 molecular_function owl:Class
GO:0016279 biolink:NamedThing protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. got7fsn_ti Reactome:R-HSA-212263|Reactome:R-HSA-8932276|Reactome:R-HSA-8865237|Reactome:R-HSA-8932275|Reactome:R-HSA-8932413|Reactome:R-HSA-8931974|Reactome:R-HSA-8932221|Reactome:R-HSA-8932243|Reactome:R-HSA-8931858 molecular_function owl:Class
GO:0030331 biolink:NamedThing estrogen receptor binding Binding to an estrogen receptor. got7fsn_ti molecular_function owl:Class
GO:0021576 biolink:NamedThing hindbrain formation The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. got7fsn_ti biological_process owl:Class
GO:0042702 biolink:NamedThing uterine wall growth The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels. got7fsn_ti biological_process owl:Class
GO:0045962 biolink:NamedThing positive regulation of development, heterochronic Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and increases the rate at which this time point is reached. got7fsn_ti stimulation of development, heterochronic|up-regulation of development, heterochronic|activation of development, heterochronic|upregulation of development, heterochronic|up regulation of development, heterochronic biological_process owl:Class
GO:0040034 biolink:NamedThing regulation of development, heterochronic Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached. got7fsn_ti developmental timing|heterochronic regulation of development|temporal regulation of development biological_process owl:Class
GO:0102003 biolink:NamedThing Delta8-sphingolipid desaturase activity Catalysis of the reaction: phytosphingosine(1+) + O2 + a reduced electron acceptor <=> 4-hydroxy-trans-8-sphingenine + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.4|MetaCyc:1.14.19.4-RXN molecular_function owl:Class
GO:0052631 biolink:NamedThing sphingolipid delta-8 desaturase activity Catalysis of the formation of a double bond between C8 and C9 of the long chain base of a sphingolipid. For example, sphinganine (d18:0) = 8-sphingenine (d18:1delta8); phytosphinganine (t18:0) = 8-phytosphingenine (t18:1delta8); and 4-sphingenine (18:1delta4) = 4,8-sphingadienine (d18:2delta4,8). got7fsn_ti RHEA:46268|MetaCyc:RXN-7798 molecular_function owl:Class
GO:0043079 biolink:NamedThing antipodal cell nucleus The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents. got7fsn_ti cellular_component owl:Class
GO:0106303 biolink:NamedThing mannogen metabolic process The chemical reactions and pathways involving mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. got7fsn_ti mannogen metabolism|beta-1,2-mannan metabolic process hjd 2020-09-09T13:49:42Z biological_process owl:Class
GO:0043604 biolink:NamedThing amide biosynthetic process The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. got7fsn_ti biological_process owl:Class
GO:0035751 biolink:NamedThing regulation of lysosomal lumen pH Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. got7fsn_ti bf 2011-03-23T10:23:41Z biological_process owl:Class
GO:0051453 biolink:NamedThing regulation of intracellular pH Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion. got7fsn_ti pH regulation in cell|regulation of cell pH|cell pH regulation|cellular pH regulation biological_process owl:Class
GO:0033783 biolink:NamedThing 25-hydroxycholesterol 7alpha-hydroxylase activity Catalysis of the reactions: cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O, and cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 = cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O. got7fsn_ti CYP7B1 oxysterol 7alpha-hydroxylase activity|25-hydroxycholesterol 7alpha-monooxygenase activity|cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity|CYP7B1 MetaCyc:RXN-7981|RHEA:19041|MetaCyc:RXN-7980|EC:1.14.14.29 molecular_function owl:Class
GO:0018890 biolink:NamedThing cyanamide metabolic process The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism. got7fsn_ti cyanamide metabolism UM-BBD_pathwayID:cnm biological_process owl:Class
GO:0071178 biolink:NamedThing MAML2-RBP-Jkappa-ICN4 complex A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML2-RBP-Jkappa-Notch4 complex mah 2009-11-23T02:49:21Z cellular_component owl:Class
GO:0103086 biolink:NamedThing methylthiopentylmalate isomerase activity Catalysis of the reaction: 2-(5'-methylthio)pentylmalate <=> 3-(5'-methylthio)pentylmalate. got7fsn_ti MetaCyc:RXNQT-4170 molecular_function owl:Class
GO:0106045 biolink:NamedThing guanine deglycation, methylglyoxal removal The removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine. got7fsn_ti hjd 2017-08-01T18:17:28Z biological_process owl:Class
GO:0106044 biolink:NamedThing guanine deglycation The removal of a sugar or dicarbonyl from a glycated guanine. got7fsn_ti hjd 2017-08-01T18:15:28Z biological_process owl:Class
GO:0033072 biolink:NamedThing vancomycin biosynthetic process The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria. got7fsn_ti vancomycin anabolism|vancomycin biosynthesis|vancomycin formation|vancomycin synthesis biological_process owl:Class
GO:0019184 biolink:NamedThing nonribosomal peptide biosynthetic process The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione. got7fsn_ti nonribosomal peptide biosynthesis|non-ribosomal peptide formation|non-ribosomal peptide synthesis|nonribosomal peptide synthesis|non-ribosomal peptide biosynthetic process|nonribosomal peptide anabolism|nonribosomal peptide synthetase|non-ribosomal peptide biosynthesis|nonribosomal peptide formation biological_process owl:Class
GO:0034525 biolink:NamedThing 1-naphthaldehyde dehydrogenase activity Catalysis of the reaction: 1-naphthaldehyde + NAD+ + H2O = 1-naphthoic acid + NADH + H+. got7fsn_ti UM-BBD_reactionID:r0787 molecular_function owl:Class
GO:0034587 biolink:NamedThing piRNA metabolic process The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. got7fsn_ti Piwi-associated RNA metabolic process|piRNA metabolism biological_process owl:Class
GO:0034660 biolink:NamedThing ncRNA metabolic process The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs). got7fsn_ti ncRNA metabolism biological_process owl:Class
GO:0009682 biolink:NamedThing induced systemic resistance A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling. got7fsn_ti biological_process owl:Class
GO:0005164 biolink:NamedThing tumor necrosis factor receptor binding Binding to a tumor necrosis factor receptor. got7fsn_ti TNF receptor binding|tumor necrosis factor|tumor necrosis factor receptor ligand molecular_function owl:Class
GO:0032813 biolink:NamedThing tumor necrosis factor receptor superfamily binding Binding to a member of the tumor necrosis factor receptor superfamily. got7fsn_ti TNF receptor superfamily binding molecular_function owl:Class
GO:0055105 biolink:NamedThing ubiquitin-protein transferase inhibitor activity Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase. got7fsn_ti molecular_function owl:Class
GO:0097486 biolink:NamedThing multivesicular body lumen The volume enclosed by the outermost membrane of a multivesicular body. got7fsn_ti pr 2013-07-08T20:32:56Z cellular_component owl:Class
GO:0031906 biolink:NamedThing late endosome lumen The volume enclosed by the membrane of a late endosome. got7fsn_ti cellular_component owl:Class
GO:0009165 biolink:NamedThing nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). got7fsn_ti nucleotide formation|nucleotide anabolism|nucleotide biosynthesis|nucleotide synthesis biological_process owl:Class
GO:0071482 biolink:NamedThing cellular response to light stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. got7fsn_ti mah 2009-12-18T02:03:49Z biological_process owl:Class
GO:0031814 biolink:NamedThing P2Y4 nucleotide receptor binding Binding to a P2Y4 nucleotide receptor. got7fsn_ti P2Y4 nucleotide receptor ligand molecular_function owl:Class
GO:1990071 biolink:NamedThing TRAPPII protein complex A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. got7fsn_ti bhm 2013-03-28T14:24:08Z cellular_component owl:Class
GO:0030008 biolink:NamedThing TRAPP complex A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active. got7fsn_ti TRAPP2|transport protein particle|TRAPP1|transport protein particle complex Wikipedia:TRAPP_complex cellular_component owl:Class
GO:0033517 biolink:NamedThing myo-inositol hexakisphosphate metabolic process The chemical reactions and pathways involving phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds. got7fsn_ti phytate metabolism|phytate metabolic process|myo-inositol hexakisphosphate metabolism biological_process owl:Class
GO:0046956 biolink:NamedThing positive phototaxis The directed movement of a cell or organism towards a source of light. got7fsn_ti positive phototactic behavior|positive taxis in response to light|positive phototactic behaviour GO:0046954 biological_process owl:Class
GO:0036215 biolink:NamedThing response to stem cell factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus. got7fsn_ti response to hematopoietic growth factor KL|response to KIT ligand|response to stem cell factor stimulus|response to SCF bf 2012-04-27T10:26:37Z biological_process owl:Class
GO:0034848 biolink:NamedThing naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA. got7fsn_ti UM-BBD_reactionID:r1261 molecular_function owl:Class
GO:0047422 biolink:NamedThing N-acyl-D-aspartate deacylase activity Catalysis of the reaction: N-acyl-D-aspartate + H(2)O = D-aspartate + a carboxylate. got7fsn_ti N-acyl-D-aspartate amidohydrolase activity RHEA:18285|KEGG_REACTION:R02182|MetaCyc:3.5.1.83-RXN|EC:3.5.1.83 molecular_function owl:Class
GO:2000196 biolink:NamedThing positive regulation of female gonad development Any process that activates or increases the frequency, rate or extent of female gonad development. got7fsn_ti positive regulation of ovarian development|positive regulation of ovary development yaf 2010-10-19T10:45:41Z biological_process owl:Class
GO:2000243 biolink:NamedThing positive regulation of reproductive process Any process that activates or increases the frequency, rate or extent of reproductive process. got7fsn_ti mah 2010-11-10T02:44:08Z biological_process owl:Class
GO:0021654 biolink:NamedThing rhombomere boundary formation The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0035333 biolink:NamedThing Notch receptor processing, ligand-dependent The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD). got7fsn_ti Notch S2 cleavage|Notch S3 cleavage bf 2010-02-26T02:31:31Z biological_process owl:Class
GO:0031293 biolink:NamedThing membrane protein intracellular domain proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. got7fsn_ti membrane protein solubilization biological_process owl:Class
GO:0150060 biolink:NamedThing amylin receptor 2 signaling pathway A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 2 (AMY2), a G protein-coupled receptor complex, on the surface of the target cell. The AMY2 signaling pathway can also be initiated by adrenomedullin (AM/ADM). got7fsn_ti AMY2 signaling pathway bc 2018-06-21T11:00:22Z biological_process owl:Class
GO:0097647 biolink:NamedThing amylin receptor signaling pathway A series of molecular signals initiated by an extracellular amylin combining with a dimeric amylin receptor on the surface of the target cell. got7fsn_ti amilyn receptor signalling pathway pr 2014-09-09T17:49:52Z biological_process owl:Class
GO:0038115 biolink:NamedThing chemokine (C-C motif) ligand 19 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti C-C chemokine receptor type 7 signaling pathway|chemokine (C-C motif) ligand 19 signalling pathway|CCL19-mediated signaling pathway The C-C chemokine CCL19 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL19-activated CCR7 signaling pathway ; GO:0038119'. bf 2012-03-22T11:28:32Z biological_process owl:Class
GO:0070098 biolink:NamedThing chemokine-mediated signaling pathway A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti chemokine-mediated signalling pathway biological_process owl:Class
GO:0039528 biolink:NamedThing cytoplasmic pattern recognition receptor signaling pathway in response to virus Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. got7fsn_ti RIG-I/MDA5 signaling pathway|virus-induced cytoplasmic pattern recognition receptor signaling pathway|RIG-like receptor signaling pathway|RLR signaling pathway|RLH signaling pathway|cytoplasmic pattern recognition receptor signalling pathway in response to virus|cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway|RIG-like helicase signaling pathway|RIG-I-like receptor (RLR) signaling pathway This term should be used for annotation when it is not known which cytoplasmic pattern recognition receptor (PRR) has detected the viral RNA. If the PRR is known, consider instead the child terms. The RIG-like family is composed of at least RIG-I (retinoic acid inducible gene I; also known as DDX58), melanoma differentiation-associated gene 5 (MDA5; also known as helicard or IFIH1) and LGP2. bf 2011-12-20T02:43:15Z biological_process owl:Class
GO:0098586 biolink:NamedThing cellular response to virus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. got7fsn_ti dos 2014-01-24T14:54:08Z biological_process owl:Class
GO:0019516 biolink:NamedThing lactate oxidation The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons. got7fsn_ti biological_process owl:Class
GO:0031001 biolink:NamedThing response to brefeldin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus. got7fsn_ti biological_process owl:Class
GO:0046677 biolink:NamedThing response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. got7fsn_ti antibiotic susceptibility/resistance biological_process owl:Class
GO:0102210 biolink:NamedThing rhamnogalacturonan endolyase activity Catalysis of the reaction: H2O + a rhamnogalacturonan type I <=> [rhamnogalacturonan I oligosaccharide]-alpha-L-rhamnose + 4-deoxy-4,5-unsaturated D-galactopyranosyluronate-[rhamnogalacturonan I oligosaccharide]. got7fsn_ti EC:4.2.2.23|MetaCyc:RXN-12173 molecular_function owl:Class
GO:0016837 biolink:NamedThing carbon-oxygen lyase activity, acting on polysaccharides Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide. got7fsn_ti EC:4.2.2.- molecular_function owl:Class
GO:0005589 biolink:NamedThing collagen type VI trimer A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils. got7fsn_ti cellular_component owl:Class
GO:0072564 biolink:NamedThing blood microparticle formation The cellular component organization process in which microparticles bud off from a parent cell. A microparticle is a phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. got7fsn_ti microparticle generation|microparticle release mah 2011-01-28T02:15:50Z biological_process owl:Class
GO:0048290 biolink:NamedThing isotype switching to IgA isotypes The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus. got7fsn_ti isotype switch recombination to IgA isotypes|class switching to IgA isotypes biological_process owl:Class
GO:0045190 biolink:NamedThing isotype switching The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. got7fsn_ti class switch recombination|class switching|isotype switch recombination Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'. Wikipedia:Immunoglobulin_class_switching biological_process owl:Class
GO:0004825 biolink:NamedThing methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). got7fsn_ti methionyl-tRNA synthetase activity|methionyl-transfer RNA synthetase activity|methionine translase activity|methionyl-transfer ribonucleic acid synthetase activity|methionyl-transfer ribonucleate synthetase activity|L-methionine:tRNAMet ligase (AMP-forming)|MetRS activity EC:6.1.1.10|RHEA:13481|MetaCyc:METHIONINE--TRNA-LIGASE-RXN|Reactome:R-HSA-379994|Reactome:R-HSA-380157 molecular_function owl:Class
GO:0102053 biolink:NamedThing (-)-jasmonoyl-isoleucine synthetase activity Catalysis of the reaction: (-)-jasmonate + L-isoleucine + ATP(4-) <=> H+ + (-)-jasmonoyl-L-isoleucine + AMP(2-) + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10435 molecular_function owl:Class
GO:0006286 biolink:NamedThing base-excision repair, base-free sugar-phosphate removal Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme. got7fsn_ti biological_process owl:Class
GO:0032996 biolink:NamedThing Bcl3-Bcl10 complex A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus. got7fsn_ti cellular_component owl:Class
GO:0033176 biolink:NamedThing proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. got7fsn_ti hydrogen-translocating V-type ATPase complex cellular_component owl:Class
GO:0034287 biolink:NamedThing detection of monosaccharide stimulus The series of events in which a stimulus from a monosaccharide is received and converted into a molecular signal. got7fsn_ti perception of monosaccharide stimulus biological_process owl:Class
GO:0034284 biolink:NamedThing response to monosaccharide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus. got7fsn_ti response to monosaccharide stimulus biological_process owl:Class
GO:0010816 biolink:NamedThing calcitonin catabolic process The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin. got7fsn_ti biological_process owl:Class
GO:0018660 biolink:NamedThing 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O. got7fsn_ti 4 HPA 3-hydroxylase activity|p-hydroxyphenylacetate hydroxylase activity|4-hydroxyphenylacetate 3-hydroxylase activity|4-hydroxyphenylacetate 3-monooxygenase activity|p-hydroxyphenylacetate 3-hydroxylase activity KEGG_REACTION:R02698|EC:1.14.14.9|RHEA:16681 molecular_function owl:Class
GO:0034232 biolink:NamedThing ascospore wall chitin catabolic process The chemical reactions and pathways resulting in the breakdown of ascospore wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of ascospores. got7fsn_ti ascospore wall chitin degradation|ascospore wall chitin breakdown|ascospore wall chitin catabolism biological_process owl:Class
GO:0071854 biolink:NamedThing cell wall macromolecule catabolic process involved in fungal-type cell wall disassembly The chemical reactions and pathways that result in the breakdown of macromolecules that form part of a cell wall, and contributes to the breakdown of the fungal-type cell wall. got7fsn_ti mah 2010-09-10T03:12:08Z biological_process owl:Class
GO:0008192 biolink:NamedThing RNA guanylyltransferase activity Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule. got7fsn_ti molecular_function owl:Class
GO:0036354 biolink:NamedThing 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+. got7fsn_ti bf 2012-09-19T14:46:31Z RHEA:19733|MetaCyc:RXN-8787 molecular_function owl:Class
GO:0002372 biolink:NamedThing myeloid dendritic cell cytokine production Any process that contributes to cytokine production by a myeloid dendritic cell. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0061082 biolink:NamedThing myeloid leukocyte cytokine production Any process that contributes to cytokine production by a myeloid cell. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. dph 2010-04-13T11:29:42Z biological_process owl:Class
GO:0000719 biolink:NamedThing photoreactive repair The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines. got7fsn_ti pyrimidine-dimer repair by photolyase biological_process owl:Class
GO:0006290 biolink:NamedThing pyrimidine dimer repair The repair of UV-induced T-T, C-T and C-C dimers. got7fsn_ti biological_process owl:Class
GO:0010943 biolink:NamedThing NADPH pyrophosphatase activity Catalysis of the reaction: NADPH + H2O = NMNH + ADP. got7fsn_ti molecular_function owl:Class
GO:0004551 biolink:NamedThing nucleotide diphosphatase activity Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. got7fsn_ti nucleotide pyrophosphatase activity|nucleotide-sugar pyrophosphatase activity|dinucleotide nucleotidohydrolase activity Reactome:R-HSA-196955|MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN|EC:3.6.1.9 molecular_function owl:Class
GO:0051604 biolink:NamedThing protein maturation Any process leading to the attainment of the full functional capacity of a protein. got7fsn_ti biological_process owl:Class
GO:0015869 biolink:NamedThing protein-DNA complex transport The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti DNA-protein complex transport biological_process owl:Class
GO:0006886 biolink:NamedThing intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. got7fsn_ti copper-induced intracellular protein transport GO:0032779 biological_process owl:Class
GO:0007440 biolink:NamedThing foregut morphogenesis The process in which the anatomical structures of the foregut are generated and organized. got7fsn_ti biological_process owl:Class
GO:0018257 biolink:NamedThing peptidyl-lysine formylation The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine. got7fsn_ti RESID:AA0211 biological_process owl:Class
GO:0018256 biolink:NamedThing protein formylation The addition of a formyl group to a protein amino acid. got7fsn_ti protein amino acid formylation biological_process owl:Class
GO:1990127 biolink:NamedThing intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered. got7fsn_ti pr 2013-06-19T13:55:06Z biological_process owl:Class
GO:0008627 biolink:NamedThing intrinsic apoptotic signaling pathway in response to osmotic stress A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered. got7fsn_ti induction of apoptosis by ionic changes biological_process owl:Class
GO:0010069 biolink:NamedThing zygote asymmetric cytokinesis in embryo sac The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana. got7fsn_ti biological_process owl:Class
GO:0010070 biolink:NamedThing zygote asymmetric cell division The division of the zygote into two daughter cells that will adopt developmentally distinct potentials. got7fsn_ti zygote asymmetric cytokinesis biological_process owl:Class
GO:0070725 biolink:NamedThing Yb body A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell. got7fsn_ti mah 2009-06-15T05:17:28Z cellular_component owl:Class
GO:0009915 biolink:NamedThing phloem sucrose loading The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink. got7fsn_ti biological_process owl:Class
GO:0110126 biolink:NamedThing phloem loading The process of loading solutes into the sieve tube or companion cell of the phloem for long distance transport from source to sink. got7fsn_ti kmv 2018-09-07T21:24:54Z biological_process owl:Class
GO:0042792 biolink:NamedThing mitochondrial rRNA transcription The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template. got7fsn_ti rRNA transcription from mitochondrial promoter biological_process owl:Class
GO:0006390 biolink:NamedThing mitochondrial transcription The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase. got7fsn_ti transcription from mitochondrial promoter https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0021706 biolink:NamedThing locus ceruleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. got7fsn_ti biological_process owl:Class
GO:0051732 biolink:NamedThing polyribonucleotide kinase activity Catalysis of the reaction: NTP + 5'-dephospho-RNA = NDP + 5'-phospho-RNA. got7fsn_ti 5'-hydroxyl polyribonucleotide kinase activity|RNA kinase activity|5'-hydroxyl RNA kinase activity|RNA 5'-hydroxyl kinase activity molecular_function owl:Class
GO:0051731 biolink:NamedThing polynucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: NTP + 5'-dephosphopolynucleotide = NDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. got7fsn_ti polynucleotide kinase activity|5'-hydroxyl polynucleotide kinase activity|5'-dephosphopolynucleotide kinase activity|polynucleotide 5'-hydroxy-kinase activity|PNK|polynucleotide 5'-hydroxyl kinase (phosphorylating) activity molecular_function owl:Class
GO:0032920 biolink:NamedThing putrescine acetylation The modification of putrescine by addition of acetyl groups. got7fsn_ti biological_process owl:Class
GO:0009445 biolink:NamedThing putrescine metabolic process The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine. got7fsn_ti putrescine metabolism biological_process owl:Class
GO:0061503 biolink:NamedThing tRNA threonylcarbamoyladenosine dehydratase Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A. got7fsn_ti dph 2013-01-22T14:22:14Z molecular_function owl:Class
GO:0061910 biolink:NamedThing autophagosome-endosome fusion The process in which an autophagosome fuses with an endosome to create an intermediate autophagic organelle called amphisome. got7fsn_ti dph 2017-06-29T17:10:43Z biological_process owl:Class
GO:0061774 biolink:NamedThing cohesin unloading Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA. got7fsn_ti DNA exit from the cohesin ring dph 2016-07-13T12:40:25Z biological_process owl:Class
GO:0045875 biolink:NamedThing negative regulation of sister chromatid cohesion Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid cohesion. got7fsn_ti down-regulation of sister chromatid cohesion|inhibition of sister chromatid cohesion|down regulation of sister chromatid cohesion|downregulation of sister chromatid cohesion biological_process owl:Class
GO:0034957 biolink:NamedThing 3-nitrophenol nitroreductase activity Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O. got7fsn_ti UM-BBD_reactionID:r1495 molecular_function owl:Class
GO:0046857 biolink:NamedThing oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti EC:1.7.1.- molecular_function owl:Class
GO:0034967 biolink:NamedThing Set3 complex A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p. got7fsn_ti HDAC3 complex|SET3C cellular_component owl:Class
GO:0047337 biolink:NamedThing dolichyl-diphosphate-polyphosphate phosphotransferase activity Catalysis of the reaction: dolichyl diphosphate + long-chain-polyphosphate = dolichol-phosphate + long-chain-polyphosphate. got7fsn_ti dolichyl-diphosphate:polyphosphate phosphotransferase activity|dolichylpyrophosphate:polyphosphate phosphotransferase activity EC:2.7.4.20|RHEA:19417|MetaCyc:2.7.4.20-RXN molecular_function owl:Class
GO:0007637 biolink:NamedThing proboscis extension reflex The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a nutritional stimulus. got7fsn_ti proboscis extension in response to nutritional stimulus|behavioral response to nutritional stimulus, proboscis extension biological_process owl:Class
GO:0061653 biolink:NamedThing ISG15 conjugating enzyme activity Isoenergetic transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y -> Y-ISG15 + X, where both the X-ISG15 and Y-ISG15 linkages are thioester bonds between the C-terminal amino acid of ISG15 and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:24:50Z molecular_function owl:Class
GO:0007488 biolink:NamedThing histoblast morphogenesis The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen. got7fsn_ti histoblast metamorphosis biological_process owl:Class
GO:0102130 biolink:NamedThing malonyl-CoA methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a malonyl-[acp] = S-adenosyl-L-homocysteine + a malonyl-[acp] methyl ester. got7fsn_ti EC:2.1.1.197|MetaCyc:RXN-11475|RHEA:17105 molecular_function owl:Class
GO:0043353 biolink:NamedThing enucleate erythrocyte differentiation The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus. got7fsn_ti enucleate red blood cell differentiation|enucleate RBC differentiation biological_process owl:Class
GO:0030218 biolink:NamedThing erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. got7fsn_ti erythropoiesis|red blood cell differentiation|erythrocyte cell differentiation|RBC differentiation Wikipedia:Erythropoiesis biological_process owl:Class
GO:0098618 biolink:NamedThing selenomethionine-tRNA ligase activity Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met). got7fsn_ti Reactome:R-HSA-2408546 molecular_function owl:Class
GO:0021999 biolink:NamedThing neural plate anterior/posterior regionalization The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate. got7fsn_ti neural plate anterior/posterior pattern formation biological_process owl:Class
GO:0034880 biolink:NamedThing citrazinate dehydrogenase activity Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1339 molecular_function owl:Class
GO:0016721 biolink:NamedThing oxidoreductase activity, acting on superoxide radicals as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor. got7fsn_ti EC:1.15.-.- molecular_function owl:Class
GO:0002447 biolink:NamedThing eosinophil mediated immunity Any process involved in the carrying out of an immune response by an eosinophil. got7fsn_ti biological_process owl:Class
GO:0120086 biolink:NamedThing (3S)-(+)-asterisca-2(9),6-diene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (3S)-(+)-asterisca-2(9),6-diene. got7fsn_ti asterisca-2(9),6-diene synthase activity krc 2017-08-02T14:55:38Z molecular_function owl:Class
GO:0004972 biolink:NamedThing NMDA glutamate receptor activity An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages. got7fsn_ti N-methyl-D-aspartate selective glutamate receptor activity|NMDA receptor The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product. Wikipedia:NMDA_receptor molecular_function owl:Class
GO:0004970 biolink:NamedThing ionotropic glutamate receptor activity Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. got7fsn_ti Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. molecular_function owl:Class
GO:0014822 biolink:NamedThing detection of wounding The series of events by which an injury stimulus is received and converted into a molecular signal. got7fsn_ti detection of injury biological_process owl:Class
GO:2000935 biolink:NamedThing positive regulation of cellotriose metabolic process Any process that activates or increases the frequency, rate or extent of cellotriose metabolic process. got7fsn_ti positive regulation of cellotriose metabolism tt 2011-08-01T12:44:24Z biological_process owl:Class
GO:0061714 biolink:NamedThing folic acid receptor activity Combining selectively with extracellular folic acid and delivering it into the cell via endocytosis. got7fsn_ti folate receptor activity dph 2015-06-23T13:36:07Z molecular_function owl:Class
GO:0038024 biolink:NamedThing cargo receptor activity Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. got7fsn_ti endocytic receptor activity|receptor activity|receptor activity involved in receptor-mediated endocytosis|transport receptor activity Notes: (1) this term and its child terms are intended for receptors that bind to and internalize molecules by receptor-mediated endocytosis. For receptors that are coupled to a signal transduction pathway, consider instead the term 'signaling receptor activity ; GO:0038023' and its children. (2) Cargo receptors transport substances by vesicular transport, not by transmembrane transport. For transmembrane transporters, consider instead the term 'transmembrane transporter activity ; GO:0022857. bf 2011-08-01T02:50:45Z Reactome:R-HSA-3000122|Reactome:R-HSA-350168 molecular_function owl:Class
GO:0006589 biolink:NamedThing octopamine biosynthetic process The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. got7fsn_ti octopamine formation|octopamine synthesis|octopamine biosynthesis|octopamine anabolism biological_process owl:Class
GO:0042136 biolink:NamedThing neurotransmitter biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. got7fsn_ti neurotransmitter synthesis|neurotransmitter biosynthetic process and storage|neurotransmitter anabolism|neurotransmitter formation|neurotransmitter biosynthesis|neurotransmitter biosynthesis and storage biological_process owl:Class
GO:0045760 biolink:NamedThing positive regulation of action potential Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti activation of action potential|up regulation of action potential|up-regulation of action potential|stimulation of action potential|upregulation of action potential biological_process owl:Class
GO:0062101 biolink:NamedThing peptidyl-aspartic acid 3-dioxygenase activity Catalysis of the reaction: protein L-aspartate + 2-oxoglutarate + O2 = protein 3-hydroxy-L-aspartate + succinate + CO2. got7fsn_ti peptide-aspartate beta-dioxygenase activity|aspartyl/asparaginyl beta-hydroxylase activity|aspartylpeptide beta-dioxygenase activity|aspartate beta-hydroxylase activity|peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity https://github.com/geneontology/go-ontology/issues/17842 dph 2018-12-06T14:01:15Z GO:0004597 RHEA:11508|MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN|EC:1.14.11.16 molecular_function owl:Class
GO:0045682 biolink:NamedThing regulation of epidermis development Any process that modulates the frequency, rate or extent of epidermis development. got7fsn_ti regulation of epidermal development|regulation of hypodermis development biological_process owl:Class
GO:0072164 biolink:NamedThing mesonephric tubule development The progression of a mesonephric tubule over time, from its initial formation to the mature structure. A mesonephric tubule is an epithelial tube that is part of the mesonephros. got7fsn_ti mah 2010-02-26T01:45:58Z biological_process owl:Class
GO:1902107 biolink:NamedThing positive regulation of leukocyte differentiation Any process that activates or increases the frequency, rate or extent of leukocyte differentiation. got7fsn_ti up regulation of leucocyte differentiation|upregulation of leukocyte differentiation|positive regulation of leucocyte differentiation|up regulation of immune cell differentiation|up regulation of leukocyte differentiation|activation of leucocyte differentiation|upregulation of immune cell differentiation|up-regulation of leukocyte differentiation|activation of immune cell differentiation|up-regulation of leucocyte differentiation|up-regulation of immune cell differentiation|upregulation of leucocyte differentiation|activation of leukocyte differentiation|positive regulation of immune cell differentiation pr 2013-05-02T17:32:52Z biological_process owl:Class
GO:0006807 biolink:NamedThing nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. got7fsn_ti nitrogen compound metabolism biological_process owl:Class
GO:0002431 biolink:NamedThing Fc receptor mediated stimulatory signaling pathway A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region. got7fsn_ti Fc receptor mediated stimulatory signalling pathway|Fc-receptor mediated stimulatory signaling pathway biological_process owl:Class
GO:0031710 biolink:NamedThing neuromedin B receptor binding Binding to a neuromedin B receptor. got7fsn_ti neuromedin B receptor ligand molecular_function owl:Class
GO:0002237 biolink:NamedThing response to molecule of bacterial origin Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin. got7fsn_ti response to bacterium associated molecule|response to bacterial associated molecule|response to bacteria associated molecule biological_process owl:Class
GO:0031158 biolink:NamedThing negative regulation of aggregate size involved in sorocarp development Any process that decreases the size of the aggregate formed during sorocarp formation. got7fsn_ti down regulation of aggregate size|down-regulation of aggregate size|inhibition of aggregate size|downregulation of aggregate size biological_process owl:Class
GO:1905332 biolink:NamedThing positive regulation of morphogenesis of an epithelium Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium. got7fsn_ti activation of epithelium morphogenesis|up-regulation of epithelium morphogenesis|up regulation of epithelium morphogenesis|up regulation of morphogenesis of an epithelium|positive regulation of epithelium morphogenesis|activation of morphogenesis of an epithelium|up-regulation of morphogenesis of an epithelium|upregulation of epithelium morphogenesis|upregulation of morphogenesis of an epithelium An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). bhm 2016-07-22T07:14:05Z biological_process owl:Class
GO:0002773 biolink:NamedThing B cell inhibitory signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response. got7fsn_ti B cell inhibitory signalling pathway|B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway|B-cell inhibitory signaling pathway biological_process owl:Class
GO:0043643 biolink:NamedThing tetracycline metabolic process The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). got7fsn_ti tetracyclin metabolic process|tetracycline metabolism|tetracyclin metabolism biological_process owl:Class
GO:0004077 biolink:NamedThing biotin-[acetyl-CoA-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)). got7fsn_ti biotin holoenzyme synthetase activity|biotin:apocarboxylase ligase activity|biotin-acetyl coenzyme A carboxylase synthetase activity|biotin-acetyl-CoA carboxylase synthetase|HCS|acetyl-CoA carboxylase biotin holoenzyme synthetase activity|acetyl coenzyme A holocarboxylase synthetase activity|acetyl CoA holocarboxylase synthetase activity|biotin--[acetyl-CoA carboxylase] synthetase activity|biotin-acetyl-CoA-carboxylase ligase activity|biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)|biotin--protein ligase activity RHEA:11756|MetaCyc:BIOTINLIG-RXN|EC:6.3.4.15 molecular_function owl:Class
GO:0000951 biolink:NamedThing methionine catabolic process to 3-methylthiopropanol The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. got7fsn_ti biological_process owl:Class
GO:0005128 biolink:NamedThing erythropoietin receptor binding Binding to an erythropoietin receptor. got7fsn_ti erythropoietin receptor ligand|erythropoietin molecular_function owl:Class
GO:0140635 biolink:NamedThing neutrophil dispersal The movement of a neutrophil away from the site of wound or infection following its initial migration to the site. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21081 pg 2021-04-13T07:06:25Z biological_process owl:Class
GO:1990266 biolink:NamedThing neutrophil migration The movement of a neutrophil within or between different tissues and organs of the body. got7fsn_ti sl 2014-01-10T00:17:47Z biological_process owl:Class
GO:0030847 biolink:NamedThing termination of RNA polymerase II transcription, exosome-dependent The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end. got7fsn_ti transcription termination from Pol II promoter, RNA polymerase(A)-independent|transcription termination from Pol II promoter, poly(A)-independent|termination of RNA polymerase II transcription, poly(A)-independent biological_process owl:Class
GO:0006369 biolink:NamedThing termination of RNA polymerase II transcription The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. got7fsn_ti transcription termination from Pol II promoter|RNA polymerase II transcription termination factor activity|transcription termination from RNA polymerase II promoter|RNA polymerase II transcription termination|RNA 3'-end formation by RNA polymerase II GO:0019224 biological_process owl:Class
GO:0071711 biolink:NamedThing basement membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane. got7fsn_ti basement membrane organisation Note that this term has no relationship to 'membrane organization ; GO:0061024' because the basement membrane is not a lipid bilayer. mah 2010-03-10T11:57:10Z biological_process owl:Class
GO:0016476 biolink:NamedThing regulation of embryonic cell shape Any process that modulates the surface configuration of an embryonic cell. got7fsn_ti shape changes of embryonic cells biological_process owl:Class
GO:0016545 biolink:NamedThing male courtship behavior, veined wing vibration The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster. got7fsn_ti male courtship behavior, wing vibration|male courtship behaviour, wing vibration|male courtship behaviour, veined wing vibration biological_process owl:Class
GO:0048065 biolink:NamedThing male courtship behavior, veined wing extension The process during courtship where the male insect extends his wings. An example of this process is found in Drosophila melanogaster. got7fsn_ti male courtship behaviour, wing extension|male courtship behavior, wing extension|male courtship behaviour, veined wing extension biological_process owl:Class
GO:0043916 biolink:NamedThing DNA-7-methylguanine glycosylase activity Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site. got7fsn_ti MetaCyc:3.2.2.21-RXN|EC:3.2.2.21 molecular_function owl:Class
GO:0003905 biolink:NamedThing alkylbase DNA N-glycosylase activity Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site. got7fsn_ti DNA-3-methyladenine glycosidase II activity|deoxyribonucleate 3-methyladenine glycosidase II|DNA glycosidase II activity|alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)|DNA-3-methyladenine glycosylase II|alkylbase DNA glycosidase activity|3-methyladenine DNA glycosylase II|AlkA GO:0004036 EC:3.2.2.21|MetaCyc:3.2.2.21-RXN molecular_function owl:Class
GO:0004521 biolink:NamedThing endoribonuclease activity Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. got7fsn_ti endonuclease G activity Reactome:R-HSA-425923|Reactome:R-HSA-6791223|Reactome:R-HSA-9023909|Reactome:R-HSA-5601910|Reactome:R-HSA-9023912|Reactome:R-HSA-5601887|Reactome:R-HSA-6814555|Reactome:R-HSA-9009936|Reactome:R-HSA-426520|Reactome:R-HSA-927836|Reactome:R-HSA-9009941 molecular_function owl:Class
GO:0102014 biolink:NamedThing beta-D-galactose-importing ATPase activity Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O <=> ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+. got7fsn_ti MetaCyc:ABC-18-RXN|RHEA:30011 molecular_function owl:Class
GO:0015407 biolink:NamedThing ABC-type monosaccharide transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported. got7fsn_ti ATPase-coupled monosaccharide transmembrane transporter activity|monosaccharide ABC transporter|ATP-dependent monosaccharide transmembrane transporter activity|monosaccharide-importing ATPase activity|monosaccharide-transporting ATPase activity https://github.com/geneontology/go-ontology/issues/17289 MetaCyc:3.6.3.17-RXN|EC:7.5.2.- molecular_function owl:Class
GO:0052167 biolink:NamedThing modulation by symbiont of host innate immune response Any process in which a symbiont modulates the frequency, rate or extent of the innate immune response of the host organism; the innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host innate immunity|modulation of host innate immune response|modulation by organism of innate immune response in other organism involved in symbiotic interaction GO:0052306 biological_process owl:Class
GO:0006431 biolink:NamedThing methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0003234 biolink:NamedThing bulbus arteriosus formation The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart. got7fsn_ti dph 2009-10-13T11:10:02Z biological_process owl:Class
GO:0039714 biolink:NamedThing cytoplasmic viral factory A viral factory located in the cytoplasm of a host cell. got7fsn_ti bf 2013-12-19T15:16:15Z cellular_component owl:Class
GO:0039713 biolink:NamedThing viral factory An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments. got7fsn_ti virus factory bf 2013-12-19T14:53:47Z VZ:1951 cellular_component owl:Class
GO:0002084 biolink:NamedThing protein depalmitoylation The removal of palymitoyl groups from a lipoprotein. got7fsn_ti biological_process owl:Class
GO:0098734 biolink:NamedThing macromolecule depalmitoylation The removal of palymitoyl groups from a macromolecule. got7fsn_ti biological_process owl:Class
GO:0032922 biolink:NamedThing circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours. got7fsn_ti diurnal variation of gene expression|circadian regulation of protein expression|diurnal variation of protein expression biological_process owl:Class
GO:0062205 biolink:NamedThing miltiradiene synthase activity Catalysis of the reaction: (+)-copalyl diphosphate = diphosphate + miltiradiene. got7fsn_ti multiradiene synthase activity dph 2020-01-03T14:05:49Z GO:0102353 MetaCyc:RXN-13338|EC:4.2.3.131|RHEA:33983 molecular_function owl:Class
GO:0070111 biolink:NamedThing organellar chromatophore A bacteroid-containing symbiosome in which the bacterial component is a genetically highly reduced cyanobacterium that is photosynthetically active and incapable of an independent existence outside its host. The chromatophore functions as a photosynthetic organelle, and has been found and characterized in the amoeba Paulinella chromatophora. got7fsn_ti Paulinella-type chromatophore cellular_component owl:Class
GO:0043660 biolink:NamedThing bacteroid-containing symbiosome A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants. got7fsn_ti cellular_component owl:Class
GO:0047519 biolink:NamedThing quinate dehydrogenase (quinone) activity Catalysis of the reaction: (-)-quinate + pyrroloquinoline-quinone = (-)-3-dehydroquinate + pyrroloquinoline-quinol. got7fsn_ti quinate:quinone 3-oxidoreductase activity|NAD(P)-independent quinate dehydrogenase activity|quinate:pyrroloquinoline-quinone 5-oxidoreductase activity MetaCyc:1.1.99.25-RXN|RHEA:23672|EC:1.1.5.8|KEGG_REACTION:R01873 molecular_function owl:Class
GO:0010227 biolink:NamedThing floral organ abscission The controlled shedding of floral organs. got7fsn_ti biological_process owl:Class
GO:0035161 biolink:NamedThing imaginal disc lineage restriction Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment. got7fsn_ti biological_process owl:Class
GO:0038192 biolink:NamedThing gastric inhibitory peptide signaling pathway The series of molecular signals generated as a consequence of a gastric inhibitory peptide (GIP) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti gastric inhibitory polypeptide receptor signaling pathway|glucose-dependent insulinotropic polypeptide signaling|GIP signaling bf 2013-09-02T15:57:49Z biological_process owl:Class
GO:0043779 biolink:NamedThing cobalt-precorrin-5A acetaldehyde-lyase activity Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde. got7fsn_ti cobalt-precorrin 5A acetaldehyde-lyase activity MetaCyc:RXN-8763|RHEA:26281 molecular_function owl:Class
GO:0016829 biolink:NamedThing lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. got7fsn_ti other lyase activity EC:4.-.-.-|Reactome:R-HSA-5696408|Reactome:R-HSA-6782895 molecular_function owl:Class
GO:0090434 biolink:NamedThing oleoyl-CoA ligase activity Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA. got7fsn_ti oleoyl-CoA synthetase activity tb 2012-07-25T03:31:31Z molecular_function owl:Class
GO:0019836 biolink:NamedThing hemolysis by symbiont of host erythrocytes The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti hemolysis by symbiont of host red blood cells|hemolysin activity|hemolysis by symbiont of host RBCs|regulation of cytolysis of host cells by symbiont|haemolysis in host|pathogenesis biological_process owl:Class
GO:0052331 biolink:NamedThing hemolysis in other organism involved in symbiotic interaction The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another, where two organisms are in a symbiotic interaction. got7fsn_ti hemolysis of cells in other organism during symbiotic interaction|hemolysis by organism of RBCs in other organism during symbiotic interaction|haemolysis in other organism involved in symbiotic interaction|hemolysis by organism of red blood cells in other organism during symbiotic interaction|hemolysis by organism of erythrocytes in other organism during symbiotic interaction|hemolysis of cells in other organism involved in symbiotic interaction|hemolysin activity biological_process owl:Class
GO:0090735 biolink:NamedThing DNA repair complex assembly The aggregation, arrangement and bonding together of a set of components to form a DNA repair complex. got7fsn_ti tb 2017-02-06T16:42:27Z biological_process owl:Class
GO:0010065 biolink:NamedThing primary meristem tissue development The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium. got7fsn_ti primary meristem histogenesis biological_process owl:Class
GO:0048508 biolink:NamedThing embryonic meristem development The process whose specific outcome is the progression of the embryonic meristem over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0021935 biolink:NamedThing cerebellar granule cell precursor tangential migration The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium. got7fsn_ti biological_process owl:Class
GO:1990392 biolink:NamedThing EFF-1 complex A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer. got7fsn_ti An example of this is eff-1 in C. elegans (G5ECA1) in PMID:24725407 (inferred from direct assay). bhm 2014-06-04T14:45:02Z cellular_component owl:Class
GO:0070324 biolink:NamedThing thyroid hormone binding Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. got7fsn_ti triiodothyronine binding|thyroxine binding molecular_function owl:Class
GO:0002434 biolink:NamedThing immune complex clearance A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. got7fsn_ti biological_process owl:Class
GO:0031556 biolink:NamedThing transcriptional attenuation by ribosome A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch. got7fsn_ti ribosome-mediated transcriptional attenuation biological_process owl:Class
GO:0031555 biolink:NamedThing transcriptional attenuation Regulation of transcription through variation in where transcription termination occurs. got7fsn_ti Wikipedia:Attenuator_(genetics) biological_process owl:Class
GO:0005614 biolink:NamedThing interstitial matrix A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens. got7fsn_ti cellular_component owl:Class
GO:0047718 biolink:NamedThing indanol dehydrogenase activity Catalysis of the reaction: indan-1-ol + NAD(P)+ = indanone + NAD(P)H + H+. got7fsn_ti indan-1-ol:NAD(P)+ 1-oxidoreductase activity EC:1.1.1.112|MetaCyc:INDANOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0004126 biolink:NamedThing cytidine deaminase activity Catalysis of the reaction: cytidine + H2O = uridine + NH3. got7fsn_ti cytosine nucleoside deaminase activity|cytidine aminohydrolase activity MetaCyc:CYTIDEAM2-RXN|RHEA:16069|Reactome:R-HSA-83677|Reactome:R-HSA-73608|EC:3.5.4.5 molecular_function owl:Class
GO:0004897 biolink:NamedThing ciliary neurotrophic factor receptor activity Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti CNTF receptor activity|gp130 molecular_function owl:Class
GO:0033197 biolink:NamedThing response to vitamin E Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus. got7fsn_ti response to DL-alpha-tocopheryl acetate|response to O-Acetyl-alpha-tocopherol|response to DL-alpha-tocopherol acetate biological_process owl:Class
GO:1901700 biolink:NamedThing response to oxygen-containing compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. got7fsn_ti response to oxygen molecular entity pr 2012-12-13T15:11:37Z biological_process owl:Class
GO:0072527 biolink:NamedThing pyrimidine-containing compound metabolic process The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. got7fsn_ti pyrimidine and derivative metabolic process|pyrimidine-containing compound metabolism mah 2011-01-04T03:27:19Z biological_process owl:Class
GO:0009918 biolink:NamedThing sterol delta7 reductase activity Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol. got7fsn_ti sterol delta-7 reductase activity MetaCyc:RXN-707 molecular_function owl:Class
GO:0001018 biolink:NamedThing mitochondrial promoter sequence-specific DNA binding Binding to a DNA region that controls the transcription of the mitochondrial DNA. got7fsn_ti LSPs binding|mitochondrial heavy strand promoter sense binding|LSP non-coding strand binding|mitochondrial proximal promoter sequence-specific DNA binding|mitochondrial RNA polymerase regulatory region DNA binding|mitochondrial RNA polymerase regulatory region sequence-specific DNA binding|LSPas binding|mitochondrial light strand promoter sense binding|HSPas binding|LSP coding strand binding|HSP coding strand binding|mitochondrial RNA polymerase core promoter sequence-specific DNA binding|mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding|mitochondrial light strand promoter anti-sense binding|HSPs binding|mitochondrial heavy strand promoter anti-sense binding|HSP non-coding strand binding krc 2010-08-25T04:11:49Z GO:0070362|GO:0001045|GO:0000997|GO:0070364|GO:0070363|GO:0070361|GO:0001044 molecular_function owl:Class
GO:0000976 biolink:NamedThing transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. got7fsn_ti transcription regulatory region sequence-specific DNA binding|regulatory region DNA binding|transcription regulatory region DNA binding https://github.com/geneontology/go-ontology/issues/19312|https://github.com/geneontology/go-ontology/issues/20791 Note that this term is meant to also capture non-specific binding to regulatory regions. Also, to minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. krc 2010-08-10T11:00:02Z GO:0000975|GO:0044212 molecular_function owl:Class
GO:0000422 biolink:NamedThing autophagy of mitochondrion The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. got7fsn_ti mitochondrion autophagy|mitophagy Wikipedia:Autophagy_(cellular)#Selective_autophagy|Wikipedia:Mitophagy biological_process owl:Class
GO:0006914 biolink:NamedThing autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. got7fsn_ti GO:0016238 Wikipedia:Autophagy_(cellular) biological_process owl:Class
GO:0061953 biolink:NamedThing mRNA (adenine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA. got7fsn_ti dph 2017-11-08T13:26:35Z molecular_function owl:Class
GO:0008298 biolink:NamedThing intracellular mRNA localization Any process in which mRNA is transported to, or maintained in, a specific location within the cell. got7fsn_ti mRNA positioning, intracellular|intracellular mRNA positioning|establishment and maintenance of intracellular RNA localization|mRNA localization, intracellular|intracellular mRNA localisation biological_process owl:Class
GO:0038175 biolink:NamedThing negative regulation of SREBP signaling pathway in response to increased oxygen levels Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels. got7fsn_ti negative regulation of SREBP-mediated signaling pathway in presence of oxygen|negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels bf 2012-07-20T01:28:59Z biological_process owl:Class
GO:2000639 biolink:NamedThing negative regulation of SREBP signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway. got7fsn_ti negative regulation of SREBP-mediated signalling pathway|negative regulation of SREBP-mediated signaling pathway vk 2011-04-20T02:46:02Z biological_process owl:Class
GO:0010222 biolink:NamedThing stem vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the stem of vascular plants. got7fsn_ti biological_process owl:Class
GO:1990664 biolink:NamedThing Nkx-2.5 complex A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes. got7fsn_ti NKX2.5 complex|Nkx-2.5 homodimer complex|NKX.2-5 homodimer complex|NKX2E homodimer complex An example of this is Nkx-2.5 in human (UniProt symbol P52952) in PMID:22849347 (inferred from direct assay). ame 2015-02-27T12:22:06Z cellular_component owl:Class
GO:0044846 biolink:NamedThing negative regulation by symbiont of indole acetic acid levels in host Any process in which an organism reduces the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of IAA levels in host|negative regulation by symbiont of auxin levels in host jl 2014-05-13T11:08:04Z biological_process owl:Class
GO:0044032 biolink:NamedThing modulation by symbiont of indole acetic acid levels in host The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of IAA levels in host|modulation by symbiont of auxin levels in host Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate indole acetic acid levels in the host, consider annotating to 'auxin homeostasis ; GO:0010252'. biological_process owl:Class
GO:0046600 biolink:NamedThing negative regulation of centriole replication Any process that stops, prevents, or reduces the frequency, rate or extent of centriole replication. got7fsn_ti down-regulation of centriole replication|inhibition of centriole replication|downregulation of centriole replication|down regulation of centriole replication biological_process owl:Class
GO:0046934 biolink:NamedThing phosphatidylinositol-4,5-bisphosphate 3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). got7fsn_ti type I phosphoinositide 3-kinase activity|phosphatidylinositol 3-kinase activity, class I|phosphatidylinositol 3-kinase, class I, catalyst activity|phosphatidylinositol 3-kinase activity, class II|ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase activity Reactome:R-HSA-2029271|Reactome:R-HSA-8852019|Reactome:R-HSA-9672177|Reactome:R-HSA-5654701|Reactome:R-HSA-5654692|Reactome:R-HSA-202365|KEGG_REACTION:R04545|Reactome:R-HSA-9665407|Reactome:R-HSA-2730870|Reactome:R-HSA-1250462|Reactome:R-HSA-437162|Reactome:R-HSA-392300|Reactome:R-HSA-2424480|Reactome:R-HSA-5654709|Reactome:R-HSA-5655289|Reactome:R-HSA-5654717|Reactome:R-HSA-5655290|MetaCyc:2.7.1.153-RXN|Reactome:R-HSA-177939|Reactome:R-HSA-1839107|Reactome:R-HSA-1226014|Reactome:R-HSA-9664940|Reactome:R-HSA-1306957|Reactome:R-HSA-5654714|Reactome:R-HSA-1839091|Reactome:R-HSA-5637801|Reactome:R-HSA-186800|Reactome:R-HSA-2316434|Reactome:R-HSA-5655235|Reactome:R-HSA-389158|Reactome:R-HSA-9021627|RHEA:21292|Reactome:R-HSA-5654690|Reactome:R-HSA-1250370|Reactome:R-HSA-5654697|Reactome:R-HSA-5654705|Reactome:R-HSA-198266|Reactome:R-HSA-9603445|Reactome:R-HSA-2076220|Reactome:R-HSA-1676048|Reactome:R-HSA-5655323|Reactome:R-HSA-5218819|Reactome:R-HSA-9672162|Reactome:R-HSA-1306979|Reactome:R-HSA-2394007|Reactome:R-HSA-9664664|EC:2.7.1.153|Reactome:R-HSA-8853323 molecular_function owl:Class
GO:0051606 biolink:NamedThing detection of stimulus The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal. got7fsn_ti stimulus sensing|perception of stimulus|stimulus detection biological_process owl:Class
GO:0120107 biolink:NamedThing bacterial-type flagellum rotor complex The rotor complex of the bacterial-type flagellum consists of a membrane-anchored ring and the motor switch complex, which participates in the conversion of proton/Na+ energy into the mechanical work of rotation and controls the direction of flagellar rotation. got7fsn_ti krc 2017-10-17T20:54:45Z cellular_component owl:Class
GO:0050495 biolink:NamedThing peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine. got7fsn_ti peptidyl-glycyl-phosphatidylethanolamine anabolism from peptidyl-glycine|peptidyl-glycyl-phosphatidylethanolamine synthesis from peptidyl-glycine|peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine RESID:AA0346 biological_process owl:Class
GO:0005934 biolink:NamedThing cellular bud tip The end of a cellular bud distal to the site of attachment to the mother cell. got7fsn_ti cellular_component owl:Class
GO:0005618 biolink:NamedThing cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21669 Not to be used for manual annotation. Please choose a more specific term: for bacteria, annotate to GO:0009274; peptidoglycan-based cell wall, for plants: annotate to GO:0009505 ; plant-type cell wall, for fungi: GO:0009277 ; fungal-type cell wall, and for archae, use GO:0030115 S-layer (see PMID:31214995). Wikipedia:Cell_wall cellular_component owl:Class
GO:0016893 biolink:NamedThing endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. got7fsn_ti endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters|5'-endonuclease activity Note that this activity can catalyze cleavage of DNA or RNA. EC:3.1.30.- molecular_function owl:Class
GO:0004519 biolink:NamedThing endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. got7fsn_ti Reactome:R-HSA-5358518|Reactome:R-HSA-5358512|Reactome:R-HSA-72180|Reactome:R-HSA-5693533|Reactome:R-HSA-5690990 molecular_function owl:Class
GO:0071700 biolink:NamedThing olfactory placode maturation A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory placode to attain its fully functional state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. got7fsn_ti mah 2010-03-02T01:10:54Z biological_process owl:Class
GO:0002491 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class II The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class II biological_process owl:Class
GO:0001119 biolink:NamedThing protein-DNA-RNA complex remodeling The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex. got7fsn_ti krc 2010-12-03T04:15:52Z biological_process owl:Class
GO:0034367 biolink:NamedThing protein-containing complex remodeling The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex. got7fsn_ti macromolecular complex remodeling biological_process owl:Class
GO:0004622 biolink:NamedThing lysophospholipase activity Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. got7fsn_ti lysophopholipase L2|lysophospholipase A1|lysophosphatidylcholine hydrolase activity|lecithinase B activity|lysophosphatidase activity|lysolecithinase activity|phosphatidase B|lecitholipase activity|2-lysophosphatidylcholine acylhydrolase activity|phospholipase B activity GO:0045126 Reactome:R-HSA-1482571|Reactome:R-HSA-8847912|Reactome:R-HSA-1482685|MetaCyc:LYSOPHOSPHOLIPASE-RXN|Reactome:R-HSA-1482629|Reactome:R-HSA-1482696|RHEA:15177|Reactome:R-HSA-6814254|Reactome:R-HSA-6814766|Reactome:R-HSA-6814778|EC:3.1.1.5|Reactome:R-HSA-1482612|Reactome:R-HSA-1482545 molecular_function owl:Class
GO:0034386 biolink:NamedThing 4-aminobutyrate:2-oxoglutarate transaminase activity Catalysis of the reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate. got7fsn_ti GABA-2-oxoglutarate transaminase activity|GABA-oxoglutarate aminotransferase activity|GABA-alpha-ketoglutarate transaminase activity|gamma-aminobutyrate:alpha-oxoglutarate aminotransferase activity|GABA-alpha-oxoglutarate aminotransferase activity|gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase activity|4-aminobutyrate-2-ketoglutarate aminotransferase activity|GABA-2-oxoglutarate aminotransferase activity|4-aminobutyrate-2-oxoglutarate transaminase activity|GABA-alpha-ketoglutarate aminotransferase activity|gamma-aminobutyrate-alpha-ketoglutarate aminotransferase activity|GABA-alpha-ketoglutaric acid transaminase activity|4-aminobutyric acid 2-ketoglutaric acid aminotransferase activity|4-aminobutyrate-2-oxoglutarate aminotransferase activity|gamma-aminobutyric acid-2-oxoglutarate transaminase activity|gamma-aminobutyric acid-alpha-ketoglutarate transaminase activity|4-aminobutanoate:2-oxoglutarate aminotransferase activity|GABA-oxoglutarate transaminase activity|gamma-aminobutyrate-alpha-ketoglutarate transaminase activity MetaCyc:GABATRANSAM-RXN|EC:2.6.1.19 molecular_function owl:Class
GO:0031472 biolink:NamedThing propanediol degradation polyhedral organelle An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase. got7fsn_ti cellular_component owl:Class
GO:0031469 biolink:NamedThing polyhedral organelle An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. got7fsn_ti BAC|bacterial microcompartment https://github.com/geneontology/go-ontology/issues/16852 cellular_component owl:Class
GO:0032120 biolink:NamedThing ascospore-type prospore membrane formation The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed. got7fsn_ti FSM biosynthesis|forespore membrane formation|FSM formation|prospore membrane biogenesis|ascospore-type prospore membrane assembly|forespore membrane biosynthesis|FSM assembly https://github.com/geneontology/go-ontology/issues/14712 GO:0099097 biological_process owl:Class
GO:0048000 biolink:NamedThing isoflavone 3'-hydroxylase activity Catalysis of the reaction: formononetin + NADPH + O2 = calycosin + NADP+ + H2O. got7fsn_ti formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating)|isoflavone 3'-monooxygenase activity EC:1.14.14.88|RHEA:22960|MetaCyc:RXN-3762 molecular_function owl:Class
GO:0018699 biolink:NamedThing 1,1,1-trichloroethane reductive dehalogenase activity Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl. got7fsn_ti EC:1.97.1.-|UM-BBD_reactionID:r1007 molecular_function owl:Class
GO:0051214 biolink:NamedThing RNAi-mediated antiviral immunity against RNA virus Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing. In plants, DCL4 is the primary Dicer to detect RNA viruses. got7fsn_ti RNA virus-induced gene silencing|RNA VIGS|RNA virus induced gene silencing https://github.com/geneontology/go-ontology/issues/19958 biological_process owl:Class
GO:0009616 biolink:NamedThing RNAi-mediated antiviral immune response RNA-mediated post-transcriptional gene silencing mechanism that protects against foreign organism invasion by restricting viral replication and dissemination. got7fsn_ti RNAi-mediated antiviral immunity|viral triggering of virus induced gene silencing|virus-induced gene silencing|VIGS|virus induced gene silencing|viral gene silencing in virus induced gene silencing https://github.com/geneontology/go-ontology/issues/19958 Virus induced gene silencing (VIGS) is used as a technique to control plant gene expression; when used in that context, this does not represent a normal biological process and is outside the scope of GO. GO:0060150|GO:0060145 biological_process owl:Class
GO:0001563 biolink:NamedThing detection of protozoan The series of events in which a stimulus from a protozoan is received and converted into a molecular signal. got7fsn_ti detection of protozoa|perception of protozoa|detection of protozoon biological_process owl:Class
GO:0005853 biolink:NamedThing eukaryotic translation elongation factor 1 complex A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. got7fsn_ti cellular_component owl:Class
GO:0044072 biolink:NamedThing negative regulation by symbiont of host cell cycle The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery. got7fsn_ti biological_process owl:Class
GO:0044071 biolink:NamedThing modulation by symbiont of host cell cycle The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery. got7fsn_ti regulation by symbiont of host cell cycle|modulation of host cell cycle by symbiont|modification by symbiont of host cell cycle biological_process owl:Class
GO:0015057 biolink:NamedThing thrombin-activated receptor activity A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. got7fsn_ti thrombin receptor activity, G-protein coupled|thrombin receptor activity GO:0010655 molecular_function owl:Class
GO:0016232 biolink:NamedThing HNK-1 sulfotransferase activity Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R). got7fsn_ti HNK-1 sulphotransferase activity Reactome:R-HSA-6786048 molecular_function owl:Class
GO:0031159 biolink:NamedThing positive regulation of aggregate size involved in sorocarp development Any process that increases the size of the aggregate formed during sorocarp formation. got7fsn_ti up-regulation of aggregate size|up regulation of aggregate size|activation of aggregate size|stimulation of aggregate size|upregulation of aggregate size biological_process owl:Class
GO:0071920 biolink:NamedThing cleavage body A nuclear body that contains proteins involved in pre-mRNA 3'-end cleavage and polyadenylation, such as DDX1, CSTF2 and CPSFs, as well as the transcription factors TFIIE and TFIIF. Cleavage bodies are localized adjacent to Cajal bodies and are involved in mRNA3'-end processing. got7fsn_ti mah 2010-09-28T10:35:05Z cellular_component owl:Class
GO:1990258 biolink:NamedThing histone glutamine methylation The modification of a histone by addition of a methyl group to an glutamine residue. got7fsn_ti sp 2014-01-02T15:08:02Z biological_process owl:Class
GO:0071220 biolink:NamedThing cellular response to bacterial lipoprotein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus. got7fsn_ti mah 2009-12-03T01:26:36Z biological_process owl:Class
GO:0052605 biolink:NamedThing gamma-tocopherol cyclase activity Catalysis of the reaction: 2,3-dimethyl-6-phytyl-1,4-benzoquinone = gamma-tocopherol. got7fsn_ti RHEA:37983|MetaCyc:RXN-2543|KEGG_REACTION:R07502 molecular_function owl:Class
GO:0140423 biolink:NamedThing effector-mediated suppression of host pattern-triggered immunity signaling A process mediated by a molecule secreted by a symbiont that results in the suppression of a pattern-triggered immunity PTI signaling pathway. PTI signaling pathways are found in plants. got7fsn_ti effector-mediated suppression of PTI signalling|effector-mediated suppression of pattern-triggered immunity signaling|effector-mediated suppression of host PRR signalling|effector-mediated suppression of host pattern recognition receptor signaling|effector-mediated suppression of host PRR signaling https://github.com/geneontology/go-ontology/issues/18683 pg 2020-02-03T09:50:33Z biological_process owl:Class
GO:0052034 biolink:NamedThing effector-mediated suppression of host pattern-triggered immunity A process mediated by a molecule secreted by a symbiont that results in the suppression of the innate immune response of the host organism via recognition of a microbe-associated molecular pattern. The innate immune response is the host's first line of defense against infection. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti suppression of pathogen-associated molecular pattern-induced host innate immunity|negative regulation by organism of pathogen-associated molecular pattern-induced innate immune response of other organism involved in symbiotic interaction|down-regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity|suppression of general elicitor-induced host innate immunity|suppression of MAMP induced host innate immunity|suppression of PAMP induced host innate immunity|suppression of PAMP-induced host innate immunity|negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immunity|downregulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity|suppression by symbiont of microbe-associated molecular pattern-induced host innate immune response|negative regulation by symbiont of microbe-associated molecular pattern-induced host innate immune response|suppression of MAMP-induced host innate immunity|down regulation by symbiont of pathogen-associated molecular pattern-induced host innate immunity|suppression of general elicitor induced host innate immunity|inhibition by symbiont of pathogen-associated molecular pattern-induced host innate immunity https://github.com/geneontology/go-ontology/issues/21161 GO:0052258 biological_process owl:Class
GO:0005042 biolink:NamedThing netrin receptor activity Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0000709 biolink:NamedThing meiotic joint molecule formation The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA. got7fsn_ti biological_process owl:Class
GO:0061533 biolink:NamedThing norepinephrine secretion, neurotransmission The regulated release of norepinephrine by a cell, in which the norepinephrine acts as a neurotransmitter. got7fsn_ti noradrenaline secretion, neurotransmission dph 2013-06-21T16:05:08Z biological_process owl:Class
GO:0048243 biolink:NamedThing norepinephrine secretion The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system. got7fsn_ti noradrenaline secretion biological_process owl:Class
GO:0038139 biolink:NamedThing ERBB4-EGFR complex A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1). got7fsn_ti EGFR-ERBB4 complex|ERBB4:EGFR heterodimer bf 2012-03-30T01:59:41Z cellular_component owl:Class
GO:0005584 biolink:NamedThing collagen type I trimer A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils. got7fsn_ti Wikipedia:Collagen_type_I cellular_component owl:Class
GO:0038016 biolink:NamedThing insulin receptor internalization A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell. got7fsn_ti insulin receptor endocytosis bf 2011-06-23T04:24:52Z biological_process owl:Class
GO:0031623 biolink:NamedThing receptor internalization A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0045579 biolink:NamedThing positive regulation of B cell differentiation Any process that activates or increases the frequency, rate or extent of B cell differentiation. got7fsn_ti up-regulation of B cell differentiation|upregulation of B cell differentiation|positive regulation of B-cell differentiation|up regulation of B cell differentiation|positive regulation of B-lymphocyte differentiation|positive regulation of B cell development|stimulation of B cell differentiation|activation of B cell differentiation|positive regulation of B lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:1901096 biolink:NamedThing regulation of autophagosome maturation Any process that modulates the frequency, rate or extent of autophagosome maturation. got7fsn_ti regulation of amphisome-lysosome fusion|regulation of autolysosome formation|regulation of fusion of autophagosome with lysosome|regulation of autophagosome maturation|regulation of autophagosome fusion|regulation of autophagic vacuole fusion lb 2012-07-10T07:22:01Z GO:1902452 biological_process owl:Class
GO:0008922 biolink:NamedThing long-chain fatty acid [acyl-carrier-protein] ligase activity Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22. got7fsn_ti long-chain-fatty-acid-acyl-carrier-protein ligase activity|acyl-acyl carrier protein synthetase|long-chain-fatty-acid-ACP ligase activity|acyl-ACP synthetase activity|stearoyl-ACP synthetase activity|long-chain-fatty-acid-[acyl-carrier protein] ligase activity|acyl-acyl-carrier-proteinsynthetase activity|long-chain fatty acid-[acyl-carrier-protein] ligase activity|long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity|long-chain-fatty-acid-[acyl-carrier-protein] ligase activity|acyl-[acyl-carrier-protein] synthetase activity|acyl-acyl-carrier-protein synthetase activity GO:0010300 KEGG_REACTION:R07325|RHEA:45588|MetaCyc:ACYLACPSYNTH-RXN|EC:6.2.1.20 molecular_function owl:Class
GO:0001980 biolink:NamedThing regulation of systemic arterial blood pressure by ischemic conditions The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system. got7fsn_ti CNS ischemic response|ischemic regulation of systemic arterial blood pressure|ischemic control of blood pressure biological_process owl:Class
GO:0044662 biolink:NamedThing disruption by virus of host cell membrane A process by which a virus has a negative effect on the functioning of a host cellular membrane. got7fsn_ti disruption by virus of host cell membrane|disruption by organism of host cell membrane jl 2012-08-01T13:44:52Z biological_process owl:Class
GO:0052025 biolink:NamedThing modification by symbiont of host cell membrane The process in which an organism effects a change in the structure or function of a host cellular membrane. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modification by symbiont of host cell membrane biological_process owl:Class
GO:0002423 biolink:NamedThing natural killer cell mediated immune response to tumor cell An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell. got7fsn_ti biological_process owl:Class
GO:0002418 biolink:NamedThing immune response to tumor cell An immune system process that functions in the response of an organism to a tumor cell. got7fsn_ti biological_process owl:Class
GO:0009933 biolink:NamedThing meristem structural organization Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue. got7fsn_ti meristem organization|meristem organisation biological_process owl:Class
GO:0047417 biolink:NamedThing N-carbamoyl-D-amino acid hydrolase activity Catalysis of the reaction: H2O + N-carbamoyl-D-amino acid = CO2 + NH3 + D-amino acid. got7fsn_ti N-carbamoyl-D-amino acid amidohydrolase activity RHEA:11000|EC:3.5.1.77|MetaCyc:3.5.1.77-RXN molecular_function owl:Class
GO:0055080 biolink:NamedThing cation homeostasis Any process involved in the maintenance of an internal steady state of cations within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0008764 biolink:NamedThing UDP-N-acetylmuramoylalanine-D-glutamate ligase activity Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. got7fsn_ti UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)|uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity|D-glutamate ligase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity|D-glutamate-adding enzyme activity|UDP-Mur-NAC-L-Ala:D-Glu ligase activity|MurD synthetase activity KEGG_REACTION:R02783|MetaCyc:UDP-NACMURALA-GLU-LIG-RXN|EC:6.3.2.9|RHEA:16429 molecular_function owl:Class
GO:0044747 biolink:NamedThing mature miRNA 3'-end processing Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends. got7fsn_ti miRNA 3' end terminal trimming|miRNA 3'-end processing|miRNA trimming jl 2012-11-15T13:45:21Z biological_process owl:Class
GO:1990467 biolink:NamedThing NuA3a histone acetyltransferase complex A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p. got7fsn_ti rb 2014-08-25T23:07:45Z cellular_component owl:Class
GO:0033100 biolink:NamedThing NuA3 histone acetyltransferase complex A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p. got7fsn_ti cellular_component owl:Class
GO:0002064 biolink:NamedThing epithelial cell development The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. got7fsn_ti biological_process owl:Class
GO:0004381 biolink:NamedThing fucosylgalactoside 3-alpha-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. got7fsn_ti histo-blood substance B-dependent galactosyltransferase activity|UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity|UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity|UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity|blood-group substance B-dependent galactosyltransferase activity|UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity|blood-group substance beta-dependent galactosyltransferase activity|histo-blood substance beta-dependent galactosyltransferase activity|fucosylglycoprotein 3-alpha-galactosyltransferase activity|B transferase activity|[blood group substance] alpha-galactosyltransferase activity|histo-blood group B transferase activity|UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity|UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity|UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity MetaCyc:2.4.1.37-RXN|Reactome:R-HSA-9034053|RHEA:14349|Reactome:R-HSA-9033961|EC:2.4.1.37 molecular_function owl:Class
GO:0103040 biolink:NamedThing aldose sugar dehydrogenase activity Catalysis of the reaction: H2O + an aldose + an oxidized electron acceptor = H+ + an aldonate + a reduced electron acceptor. got7fsn_ti MetaCyc:RXN0-6371 molecular_function owl:Class
GO:0071431 biolink:NamedThing tRNA-containing ribonucleoprotein complex export from nucleus The directed movement of a ribonucleoprotein complex that contains transfer RNA from the nucleus to the cytoplasm. got7fsn_ti tRNA-containing ribonucleoprotein complex nucleus export|tRNA-containing RNP export from nucleus|tRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm|tRNA-containing ribonucleoprotein complex export from cell nucleus mah 2009-12-16T10:27:03Z biological_process owl:Class
GO:0071194 biolink:NamedThing Kv4.2-KChIP3 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2. got7fsn_ti mah 2009-11-23T04:58:41Z CORUM:608 cellular_component owl:Class
GO:0048792 biolink:NamedThing spontaneous exocytosis of neurotransmitter The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell. got7fsn_ti spontaneous synaptic vesicle exocytosis biological_process owl:Class
GO:0102997 biolink:NamedThing progesterone 5beta- reductase activity Catalysis of the reaction: H+ + progesterone + NADPH <=> 5beta-pregnane-3,20-dione + NADP. got7fsn_ti MetaCyc:RXN-9726 molecular_function owl:Class
GO:0036398 biolink:NamedThing TCR signalosome A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology. got7fsn_ti LAT signalosome|linker for activation of T cells signalosome bf 2013-07-18T13:52:24Z cellular_component owl:Class
GO:0099571 biolink:NamedThing postsynaptic cytoskeleton The portion of the cytoskeleton contained within the postsynapse. got7fsn_ti cellular_component owl:Class
GO:0097119 biolink:NamedThing postsynaptic density protein 95 clustering The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. got7fsn_ti Dlg4 clustering|post-synaptic density protein 95 clustering|PSD-95 clustering pr 2011-07-31T05:49:44Z biological_process owl:Class
GO:0072657 biolink:NamedThing protein localization to membrane A process in which a protein is transported to, or maintained in, a specific location in a membrane. got7fsn_ti protein localization in membrane|protein localisation in membrane mah 2011-02-14T02:35:18Z biological_process owl:Class
GO:0042784 biolink:NamedThing evasion of host immune response via regulation of host complement system Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti active immune evasion via regulation of host complement system|active immune evasion via modulation of host complement system|active evasion of host immune response via regulation of host complement system|active evasion of immune response of other organism via regulation of complement system of other organism involved in symbiotic interaction GO:0051811 biological_process owl:Class
GO:0042783 biolink:NamedThing evasion of host immune response A process by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti passive evasion of immune response of other organism involved in symbiotic interaction|mitigation of host immune response|immune evasion|active evasion of immune response of other organism involved in symbiotic interaction|passive evasion of host immune response|evasion or tolerance of host immune response|active immune evasion|active evasion of host immune response|passive immune evasion https://github.com/geneontology/go-ontology/issues/17894|https://github.com/geneontology/go-ontology/issues/18357 GO:0020012|GO:0042782|GO:0051810|GO:0051809|GO:0051805 biological_process owl:Class
GO:0035355 biolink:NamedThing Toll-like receptor 2-Toll-like receptor 6 protein complex A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6). got7fsn_ti TLR6:TLR2 complex|TLR2:TLR6 heterodimer|TLR2-TLR6 protein complex|toll-like receptor TLR6:TLR2 heterodimeric complex bf 2010-03-04T04:37:00Z GO:0038126 cellular_component owl:Class
GO:0007567 biolink:NamedThing parturition The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs. got7fsn_ti giving birth|egg laying biological_process owl:Class
GO:0044703 biolink:NamedThing multi-organism reproductive process A biological process that directly contributes to the process of producing new individuals, involving another organism. got7fsn_ti jl 2012-09-19T15:56:30Z biological_process owl:Class
GO:0006836 biolink:NamedThing neurotransmitter transport The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. got7fsn_ti sodium:neurotransmitter transport biological_process owl:Class
GO:0070290 biolink:NamedThing N-acylphosphatidylethanolamine-specific phospholipase D activity Catalysis of the release of N-acylethanolamine from N-acyl-phosphatidylethanolamine (NAPE) to generate N-acylethanolamine (NAE). got7fsn_ti N-acyl-phosphatidylethanolamine-specific phospholipase D activity|NAPE-specific phospholipase D activity Reactome:R-HSA-2466831|EC:3.1.4.4 molecular_function owl:Class
GO:0031489 biolink:NamedThing myosin V binding Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. got7fsn_ti molecular_function owl:Class
GO:0060801 biolink:NamedThing negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway The transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast. got7fsn_ti negative regulation of trophoblast cell differentiation by transforming growth factor beta signalling pathway dph 2009-08-06T01:24:24Z biological_process owl:Class
GO:0070369 biolink:NamedThing beta-catenin-TCF7L2 complex A protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. got7fsn_ti beta-catenin-TCF4 complex cellular_component owl:Class
GO:0045443 biolink:NamedThing juvenile hormone secretion The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. got7fsn_ti biological_process owl:Class
GO:0090295 biolink:NamedThing nitrogen catabolite repression of transcription A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. got7fsn_ti nitrogen catabolite repression|negative regulation of transcription by nitrogen catabolites tb 2010-02-24T02:31:53Z biological_process owl:Class
GO:0090293 biolink:NamedThing nitrogen catabolite regulation of transcription A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. got7fsn_ti regulation of transcription by nitrogen catabolites tb 2010-02-24T02:31:53Z biological_process owl:Class
GO:0097733 biolink:NamedThing photoreceptor cell cilium A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment. got7fsn_ti photoreceptor cilium pr 2016-09-30T10:50:11Z cellular_component owl:Class
GO:0097731 biolink:NamedThing 9+0 non-motile cilium A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). got7fsn_ti 9+0 immotile cilium|primary cilium|non-motile 9+0 cilium This type of cilia may be present in solitary (authentic primary cilia in many cell types) or in multiple copies (e.g. in Grueneberg ganglion neurons). pr 2016-09-29T14:05:03Z cellular_component owl:Class
GO:0102659 biolink:NamedThing UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 4-methylthiobutylhydroximate <=> H+ + 3-methylthiopropyl-desulfoglucosinolate + UDP. got7fsn_ti EC:2.4.1.195|MetaCyc:RXN-2208 molecular_function owl:Class
GO:1990446 biolink:NamedThing U1 snRNP binding Binding to a U1 small nuclear ribonucleoprotein particle. got7fsn_ti mah 2014-08-06T09:29:44Z molecular_function owl:Class
GO:0090177 biolink:NamedThing establishment of planar polarity involved in neural tube closure Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. got7fsn_ti tb 2009-12-14T10:38:46Z biological_process owl:Class
GO:0009371 biolink:NamedThing positive regulation of transcription by pheromones Any process involving pheromones that activates or increases the rate of transcription. got7fsn_ti up regulation of transcription by pheromones|activation of transcription by pheromones|upregulation of transcription by pheromones|up-regulation of transcription by pheromones|stimulation of transcription by pheromones biological_process owl:Class
GO:1990887 biolink:NamedThing 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+. got7fsn_ti sl 2015-10-28T22:17:54Z molecular_function owl:Class
GO:0000974 biolink:NamedThing Prp19 complex A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. got7fsn_ti nineteen complex|NTC|Prp19/CDC5 complex krc 2009-10-12T10:01:30Z cellular_component owl:Class
GO:0102587 biolink:NamedThing cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-O-(glucosyl)-p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoylglucose glucosyltransferase activity Catalysis of the reaction: cyanidin 3-O-[2''-O-(2'''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[6-O-(4-O-beta-D-glucosyl-p-coumaroyl)-2-O-(2-O-sinapoyl-beta-D-xylosyl)-beta-D-glucosyl]-5-O-(6-O-malonyl-beta-D-glucoside) + trans-sinapate + H+. got7fsn_ti MetaCyc:RXN-15333 molecular_function owl:Class
GO:0034980 biolink:NamedThing FHL2-CREB complex A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation. got7fsn_ti cellular_component owl:Class
GO:0033202 biolink:NamedThing DNA helicase complex A protein complex that possesses DNA helicase activity. got7fsn_ti cellular_component owl:Class
GO:0102002 biolink:NamedThing valine N-monooxygenase (oxime forming) activity Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O. got7fsn_ti RHEA:28606|MetaCyc:1.14.13.118-RXN|EC:1.14.14.38 molecular_function owl:Class
GO:0034916 biolink:NamedThing 2-methylhexanoyl-CoA dehydrogenase activity Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-. got7fsn_ti UM-BBD_reactionID:r0928|EC:1.3.99.- molecular_function owl:Class
GO:0036339 biolink:NamedThing lymphocyte adhesion to endothelial cell of high endothelial venule The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream. got7fsn_ti lymphocyte adhesion to HEV cell|lymphocyte adhesion to high endothelial venule For the transition of leukocytes from rolling to adhered, consider instead annotating to 'leukocyte adhesive activation ; GO:0050902'. bf 2012-09-10T16:00:23Z biological_process owl:Class
GO:0140468 biolink:NamedThing HRI-mediated signaling A series of reactions in which a signal is passed on to downstream proteins within the cell via HRI (also known as EIF2AK1), an intracellular protein kinase that is activated by stress signals, such as heme deficiency, oxidative stress, osmotic shock, mitochondrial dysfunction and heat shock. got7fsn_ti EIF2AK1-mediated signaling https://github.com/geneontology/go-ontology/issues/19153 pg 2020-05-26T08:46:15Z biological_process owl:Class
GO:0140467 biolink:NamedThing integrated stress response signaling The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. got7fsn_ti ISR https://github.com/geneontology/go-ontology/issues/19153 pg 2020-05-26T08:04:10Z Wikipedia:Integrated_stress_response biological_process owl:Class
GO:0047488 biolink:NamedThing heparin lyase activity Catalysis of the eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their nonreducing ends. got7fsn_ti heparan sulfate lyase activity|heparinase activity|heparin eliminase activity EC:4.2.2.7|MetaCyc:4.2.2.7-RXN molecular_function owl:Class
GO:0030732 biolink:NamedThing methionine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine. got7fsn_ti S-adenosylmethionine transmethylase activity|methionine methyltransferase activity|S-adenosylmethionine-methionine methyltransferase activity|S-adenosyl methionine:methionine methyl transferase activity|S-adenosyl-L-methionine:L-methionine S-methyltransferase activity RHEA:13761|MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN|EC:2.1.1.12 molecular_function owl:Class
GO:0003861 biolink:NamedThing 3-isopropylmalate dehydratase activity Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. got7fsn_ti alpha-IPM isomerase activity|beta-isopropylmalate dehydratase activity|(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)|alpha-isopropylmalate isomerase activity|(2R,3S)-3-isopropylmalate hydro-lyase activity|isopropylmalate isomerase activity EC:4.2.1.33|RHEA:32287|MetaCyc:3-ISOPROPYLMALISOM-RXN molecular_function owl:Class
GO:0050870 biolink:NamedThing positive regulation of T cell activation Any process that activates or increases the frequency, rate or extent of T cell activation. got7fsn_ti positive regulation of T-lymphocyte activation|positive regulation of T lymphocyte activation|up regulation of T cell activation|upregulation of T cell activation|stimulation of T cell activation|up-regulation of T cell activation|positive regulation of T-cell activation|activation of T cell activation biological_process owl:Class
GO:0047384 biolink:NamedThing [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase activity Catalysis of the reaction: H2O + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate = phosphate + [hydroxymethylglutaryl-CoA reductase (NADPH)]. got7fsn_ti hydroxymethylglutaryl-CoA reductase (NADPH)-phosphate phosphohydrolase activity|hydroxymethylglutaryl-CoA reductase (NADPH)-phosphatase activity|reductase phosphatase activity MetaCyc:3.1.3.47-RXN|EC:3.1.3.47 molecular_function owl:Class
GO:0050286 biolink:NamedThing sorbitol-6-phosphatase activity Catalysis of the reaction: D-glucitol 6-phosphate + H(2)O = D-glucitol + phosphate. got7fsn_ti sorbitol-6-phosphate phosphatase activity|sorbitol-6-phosphate phosphohydrolase activity RHEA:24580|EC:3.1.3.50|KEGG_REACTION:R02866|MetaCyc:SORBITOL-6-PHOSPHATASE-RXN molecular_function owl:Class
GO:0033774 biolink:NamedThing basal labyrinth A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane. got7fsn_ti cellular_component owl:Class
GO:0072151 biolink:NamedThing mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesangial cell. got7fsn_ti mah 2010-02-24T02:11:13Z biological_process owl:Class
GO:0052618 biolink:NamedThing coenzyme F420-0:L-glutamate ligase activity Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate. got7fsn_ti RHEA:30555|MetaCyc:RXN-8080|EC:6.3.2.31 molecular_function owl:Class
GO:0021770 biolink:NamedThing parahippocampal gyrus development The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex. got7fsn_ti hippocampal gyrus development Wikipedia:parahippocampal_gyrus biological_process owl:Class
GO:0008036 biolink:NamedThing diuretic hormone receptor activity Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0015144 biolink:NamedThing carbohydrate transmembrane transporter activity Enables the transfer of carbohydrate from one side of a membrane to the other. got7fsn_ti carbohydrate transporter activity|sugar transporter GO:1901476 molecular_function owl:Class
GO:0034793 biolink:NamedThing cyclopropanecarboxylate-CoA ligase activity Catalysis of the reaction: cyclopropanecarboxylate + CoASH = cyclopropanecarboxyl-CoA + OH-. got7fsn_ti UM-BBD_reactionID:r1056 molecular_function owl:Class
GO:0047271 biolink:NamedThing glycosaminoglycan galactosyltransferase activity Catalysis of the reaction: glycosaminoglycan + UDP-galactose = D-galactosylglycosaminoglycan + UDP. got7fsn_ti UDPgalactose:glycosaminoglycan D-galactosyltransferase activity|uridine diphosphogalactose-mucopolysaccharide galactosyltransferase activity|UDP-galactose:glycosaminoglycan D-galactosyltransferase activity EC:2.4.1.74|MetaCyc:2.4.1.74-RXN molecular_function owl:Class
GO:0071266 biolink:NamedThing 'de novo' L-methionine biosynthetic process The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid, from simpler components. got7fsn_ti 'de novo' L-methionine synthesis|'de novo' L-methionine anabolism|'de novo' L-methionine formation|'de novo' L-methionine biosynthesis mah 2009-12-09T04:34:41Z biological_process owl:Class
GO:0071265 biolink:NamedThing L-methionine biosynthetic process The chemical reactions and pathways resulting in the formation of L-methionine, the L-enantiomer of (2S)-2-amino-4-(methylsulfanyl)butanoic acid. got7fsn_ti L-methionine anabolism|L-methionine biosynthesis|L-methionine synthesis|L-methionine formation mah 2009-12-09T04:28:15Z biological_process owl:Class
GO:0044375 biolink:NamedThing regulation of peroxisome size Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. got7fsn_ti jl 2011-12-01T04:37:59Z biological_process owl:Class
GO:0047198 biolink:NamedThing cysteine-S-conjugate N-acetyltransferase activity Catalysis of the reaction: S-substituted L-cysteine + acetyl-CoA = S-substituted N-acetyl-L-cysteine + CoA + H(+). got7fsn_ti acetyl-CoA:S-substituted L-cysteine N-acetyltransferase activity EC:2.3.1.80|RHEA:19213|KEGG_REACTION:R04950|MetaCyc:2.3.1.80-RXN|Reactome:R-HSA-5433066 molecular_function owl:Class
GO:1990784 biolink:NamedThing response to dsDNA Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. got7fsn_ti response to double-stranded DNA sl 2015-06-24T17:54:13Z biological_process owl:Class
GO:0045836 biolink:NamedThing positive regulation of meiotic nuclear division Any process that activates or increases the frequency, rate or extent of meiosis. got7fsn_ti activation of meiosis|up-regulation of meiosis|upregulation of meiosis|positive regulation of meiosis|up regulation of meiosis|stimulation of meiosis biological_process owl:Class
GO:0040020 biolink:NamedThing regulation of meiotic nuclear division Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes. got7fsn_ti regulation of meiosis biological_process owl:Class
GO:0005705 biolink:NamedThing polytene chromosome interband A stretch of less tightly packed chromatin along the polytene chromosome, found between bands. got7fsn_ti cellular_component owl:Class
GO:0034399 biolink:NamedThing nuclear periphery The portion of the nuclear lumen proximal to the inner nuclear membrane. got7fsn_ti cellular_component owl:Class
GO:0009555 biolink:NamedThing pollen development The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates. got7fsn_ti pollen grain formation|microgametophyte development|formation of generative and vegetative cells|male gametophyte development|male gametophyte formation GO:0048231|GO:0009564 biological_process owl:Class
GO:0048229 biolink:NamedThing gametophyte development The process whose specific outcome is the progression of the gametophyte over time, from its formation to the mature structure. The gametophyte is the gamete-producing individual or phase in the life cycle having alternation of generations. An example of this process is found in Arabidopsis thaliana. got7fsn_ti gametogenesis biological_process owl:Class
GO:0099154 biolink:NamedThing serotonergic synapse A synapse that uses serotonin as a neurotransmitter. got7fsn_ti dos 2017-07-05T14:22:05Z cellular_component owl:Class
GO:0016152 biolink:NamedThing mercury (II) reductase activity Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH. got7fsn_ti mercury(II) reductase activity|Hg:NADP+ oxidoreductase activity|mer A|reduced NADP:mercuric ion oxidoreductase activity|mercuric reductase activity|mercuric ion reductase activity|mercury reductase activity|mercurate(II) reductase activity GO:0018692 KEGG_REACTION:R02807|EC:1.16.1.1|MetaCyc:MERCURY-II-REDUCTASE-RXN|UM-BBD_reactionID:r0406|RHEA:23856 molecular_function owl:Class
GO:0001886 biolink:NamedThing endothelial cell morphogenesis The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell. got7fsn_ti biological_process owl:Class
GO:0003382 biolink:NamedThing epithelial cell morphogenesis The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state. got7fsn_ti dph 2009-12-09T07:21:06Z biological_process owl:Class
GO:0044579 biolink:NamedThing butyryl-CoA biosynthetic process from acetyl-CoA The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA. got7fsn_ti butyryl-CoA biosynthesis from acetyl-CoA jl 2012-04-19T04:25:07Z biological_process owl:Class
GO:0006084 biolink:NamedThing acetyl-CoA metabolic process The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. got7fsn_ti acetyl coenzyme A metabolism|acetyl coenzyme A metabolic process|acetyl-CoA metabolism biological_process owl:Class
GO:0051741 biolink:NamedThing 2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone + S-adenosyl-methionine = 2,3-dimethyl-6-phytyl-1,4-benzoquinone + S-adenosyl-homocysteine. got7fsn_ti MPBQ methyltransferase activity MetaCyc:RXN-2542|RHEA:37979 molecular_function owl:Class
GO:0031707 biolink:NamedThing endothelin A receptor binding Binding to an endothelin A receptor. got7fsn_ti endothelin A receptor ligand|endothelin-1 receptor binding molecular_function owl:Class
GO:0035517 biolink:NamedThing PR-DUB complex A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively. got7fsn_ti Polycomb repressive deubiquitinase complex bf 2010-05-04T04:19:02Z cellular_component owl:Class
GO:0031519 biolink:NamedThing PcG protein complex A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure. got7fsn_ti Polycomb Group protein complex cellular_component owl:Class
GO:0019988 biolink:NamedThing charged-tRNA amino acid modification The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine. got7fsn_ti pre-translational protein modification|charged tRNA modification|pre-translational amino acid modification|pretranslation protein modification|charged-tRNA modification|pretranslational amino acid modification|charged tRNA amino acid modification GO:0030630 biological_process owl:Class
GO:1990000 biolink:NamedThing amyloid fibril formation The generation of amyloid fibrils, insoluble fibrous protein aggregates exhibiting beta sheet structure, from proteins. got7fsn_ti amyloid fibril assembly|amyloid structure assembly|amyloid structure formation Although deposition of amyloid fibrils is associated with diseases, e.g. Alzheimer's disease, amyloid formation is a normal process. Disease occurs when the balance between amyloid formation and clearance is disrupted (reviewed e.g. in PMID:29654159 and PMID:28937655). An example of a normal amyloid complex is composed of human RIP1 and RIP3 kinases (PMID:22817896). pr 2012-11-27T16:01:02Z biological_process owl:Class
GO:0061450 biolink:NamedThing trophoblast cell migration Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst. got7fsn_ti dph 2012-07-10T08:38:37Z biological_process owl:Class
GO:0015968 biolink:NamedThing stringent response A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation. got7fsn_ti Wikipedia:Stringent_response biological_process owl:Class
GO:0097383 biolink:NamedThing dIDP diphosphatase activity Catalysis of the reaction: dIDP + H2O = dIMP + phosphate. got7fsn_ti deoxyinosine-diphosphatase activity pr 2012-10-11T16:04:40Z RHEA:35211|Reactome:R-HSA-2509793 molecular_function owl:Class
GO:0097382 biolink:NamedThing deoxynucleoside-diphosphatase activity Catalysis of the reaction: a deoxynucleoside diphosphate + H2O = a deoxynucleotide + phosphate. got7fsn_ti pr 2012-10-11T16:03:22Z molecular_function owl:Class
GO:0070044 biolink:NamedThing synaptobrevin 2-SNAP-25-syntaxin-1a complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 1a (or orthologs thereof). got7fsn_ti Snap25-Stx1a-Vamp2 complex|SNARE complex (Stx1a, SNAP25, VAMP)|SNARE complex (Snap25, Stx1a, Vamp2)|Stx1a-SNAP25-VAMP complex cellular_component owl:Class
GO:0102622 biolink:NamedThing linuron hydrolase activity Catalysis of the reaction: linuron + H2O <=> N,O-dimethylhydroxylamine + carbon dioxide + 3,4-dichloroaniline. got7fsn_ti MetaCyc:RXN-15526 molecular_function owl:Class
GO:0048773 biolink:NamedThing erythrophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance. got7fsn_ti erythrophore cell differentiation biological_process owl:Class
GO:0097547 biolink:NamedThing synaptic vesicle protein transport vesicle A cytoplasmic vesicle composed of both tubulovesicular and clear core vesicles that transport synaptic vesicle-associated proteins. Proteins carried by synaptic vesicle protein transport vesicles (STVs) include synaptophysin, synapsin Ia, synaptotagmin and synaptobrevin/vesicle-associated membrane protein 2 (VAMP2). STVs are packaged via the trans-Golgi network before being transported through the axon. got7fsn_ti STV This term should not be confused with GO:0008021 'synaptic vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles. pr 2013-12-20T09:22:03Z cellular_component owl:Class
GO:0016990 biolink:NamedThing arginine deiminase activity Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3. got7fsn_ti citrulline iminase activity|L-arginine deiminase activity|L-arginine iminohydrolase activity|arginine dihydrolase activity RHEA:19597|EC:3.5.3.6|MetaCyc:ARGININE-DEIMINASE-RXN molecular_function owl:Class
GO:0042132 biolink:NamedThing fructose 1,6-bisphosphate 1-phosphatase activity Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. got7fsn_ti FBPase activity|fructose 1,6-diphosphatase activity|D-fructose-1,6-bisphosphate 1-phosphohydrolase activity|fructose 1,6-diphosphate phosphatase activity|fructose 1,6-bisphosphate phosphatase activity|D-fructose 1,6-diphosphatase activity|hexose bisphosphatase activity|D-fructose-1,6-bisphosphate phosphatase activity|fructose diphosphatase activity|fructose bisphosphate phosphatase activity|hexosediphosphatase activity|fructose-1,6-bisphosphatase activity|fructose 1,6-bisphosphatase activity|fructose diphosphate phosphatase activity|fructose-bisphosphatase activity|hexose diphosphatase activity EC:3.1.3.11|MetaCyc:F16BDEPHOS-RXN|RHEA:11064|Reactome:R-HSA-70479 molecular_function owl:Class
GO:0072263 biolink:NamedThing metanephric intraglomerular mesangial cell proliferation The multiplication or reproduction of intraglomerular glomerular mesangium cells in the metanephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. got7fsn_ti mah 2010-03-30T02:27:53Z biological_process owl:Class
GO:0072123 biolink:NamedThing intraglomerular mesangial cell proliferation The multiplication or reproduction of intraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. got7fsn_ti mah 2010-02-22T01:44:29Z biological_process owl:Class
GO:0071086 biolink:NamedThing alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface proteins CD9 and CD47, and the heterodimeric platelet glycoprotein Ib. got7fsn_ti ITGA2b-ITGB3-CD9-GP1b-CD47 complex mah 2009-11-06T04:45:08Z cellular_component owl:Class
GO:0090665 biolink:NamedThing glycoprotein complex A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. got7fsn_ti An example is the Dictyostelium multi protein pspB complex, which is secreted from prespore vesicles and incorporated into the spore coat. tb 2015-12-11T17:45:23Z cellular_component owl:Class
GO:0032369 biolink:NamedThing negative regulation of lipid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti inhibition of lipid transport|down-regulation of lipid transport|down regulation of lipid transport|downregulation of lipid transport biological_process owl:Class
GO:0032368 biolink:NamedThing regulation of lipid transport Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0047490 biolink:NamedThing pectin lyase activity Catalysis of the reaction: a pectin = an oligosaccharide with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronate end + a pectin. This reaction is the eliminative cleavage of (1->4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their nonreducing ends. got7fsn_ti PL activity|pectolyase activity|endo-pectin lyase activity|PNL activity|pectin trans-eliminase activity|polymethylgalacturonic transeliminase activity|PMGL activity|(1->4)-6-O-methyl-alpha-D-galacturonan lyase activity|pectin methyltranseliminase activity EC:4.2.2.10|MetaCyc:4.2.2.10-RXN molecular_function owl:Class
GO:0039526 biolink:NamedThing modulation by virus of host apoptotic process Any process in which a virus modulates the frequency, rate or extent of apoptosis of infected host cells. got7fsn_ti modulation by virus of host apoptosis|regulation by virus of host apoptosis|modulation of host cell apoptosis by virus bf 2011-06-22T05:22:53Z VZ:1581 biological_process owl:Class
GO:0034083 biolink:NamedThing type III polyketide synthase complex A polyketide synthase complex that consists of two identical ketosynthase polypeptides. got7fsn_ti type III polyketide synthase|type III PKS|type III PKS complex cellular_component owl:Class
GO:0034081 biolink:NamedThing polyketide synthase complex A protein complex that carries out enzymatic reactions involved in the biosynthesis of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones. got7fsn_ti PKS complex|PKS cellular_component owl:Class
GO:0071629 biolink:NamedThing cytoplasm protein quality control by the ubiquitin-proteasome system The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are targeted to cytoplasmic proteasomes for degradation. got7fsn_ti cytoplasm-associated proteasomal ubiquitin-dependent protein breakdown|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolism|cytoplasm-associated proteasomal ubiquitin-dependent protein degradation|ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. mah 2010-02-11T03:06:57Z biological_process owl:Class
GO:0140455 biolink:NamedThing cytoplasm protein quality control The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the cytoplasm, which are either targeted to cytoplasmic proteasomes for degradation or protected by chaperones to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19172 pg 2020-04-20T15:46:20Z biological_process owl:Class
GO:0031956 biolink:NamedThing medium-chain fatty acid-CoA ligase activity Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12. got7fsn_ti medium-chain-fatty-acid-CoA ligase activity|medium-chain fatty acid activation|medium-chain fatty-acid-CoA ligase activity https://github.com/geneontology/go-ontology/issues/18967 EC:6.2.1.2|RHEA:48340 molecular_function owl:Class
GO:0090732 biolink:NamedThing cofilin-actin rod A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and disulfide cross-linked cofilin multimers. got7fsn_ti tb 2017-01-31T17:44:04Z cellular_component owl:Class
GO:0031002 biolink:NamedThing actin rod A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions. got7fsn_ti cellular_component owl:Class
GO:0030149 biolink:NamedThing sphingolipid catabolic process The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). got7fsn_ti sphingolipid breakdown|sphingolipid degradation|sphingolipid catabolism biological_process owl:Class
GO:0046466 biolink:NamedThing membrane lipid catabolic process The chemical reactions and pathways resulting in the breakdown of membrane lipids, any lipid found in or associated with a biological membrane. got7fsn_ti membrane lipid degradation|membrane lipid breakdown|membrane lipid catabolism|membrane lipid peroxidation biological_process owl:Class
GO:0150024 biolink:NamedThing oxidised low-density lipoprotein particle clearance The process in which an oxidised low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. got7fsn_ti ox-LDL particle clearance|oxidised LDL particle clearance|oxLDL particle clearance|oxidized low-density lipoprotein particle clearance|oxidized LDL particle clearance bc 2018-02-05T16:14:05Z biological_process owl:Class
GO:0034381 biolink:NamedThing plasma lipoprotein particle clearance The process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. got7fsn_ti lipoprotein particle clearance biological_process owl:Class
GO:0044719 biolink:NamedThing regulation of imaginal disc-derived wing size Any process that modulates the size of an imaginal disc-derived wing. got7fsn_ti jl 2012-10-18T13:49:12Z biological_process owl:Class
GO:0061484 biolink:NamedThing hematopoietic stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells. got7fsn_ti dph 2012-12-04T09:41:02Z biological_process owl:Class
GO:0099046 biolink:NamedThing clearance of foreign intracellular nucleic acids A defense process that protects an organism from DNA or RNA from an invading organism. got7fsn_ti biological_process owl:Class
GO:0043203 biolink:NamedThing axon hillock Portion of the neuronal cell soma from which the axon originates. got7fsn_ti NIF_Subcellular:sao627227260|Wikipedia:Axon_hillock cellular_component owl:Class
GO:0047140 biolink:NamedThing glutathione-CoA-glutathione transhydrogenase activity Catalysis of the reaction: oxidized glutathione + CoA = reduced glutathione + CoA-glutathione. got7fsn_ti glutathione-coenzyme A glutathione disulfide transhydrogenase activity|glutathione:coenzyme A-glutathione transhydrogenase activity|CoA:glutathione-disulfide oxidoreductase activity|glutathione coenzyme A-glutathione transhydrogenase activity|coenzyme A:oxidized-glutathione oxidoreductase activity|coenzyme A:glutathione-disulfide oxidoreductase activity RHEA:13125|EC:1.8.4.3|MetaCyc:1.8.4.3-RXN molecular_function owl:Class
GO:1990787 biolink:NamedThing negative regulation of hh target transcription factor activity Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling. got7fsn_ti negative regulation of hedgehog target transcription factor bhm 2015-06-26T09:54:29Z biological_process owl:Class
GO:0051090 biolink:NamedThing regulation of DNA-binding transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. got7fsn_ti regulation of DNA binding transcription factor activity|regulation of thyroid hormone receptor activity|regulation of transcription factor activity|regulation of androgen receptor activity|regulation of sequence-specific DNA binding transcription factor activity GO:1904167|GO:2000823 biological_process owl:Class
GO:0047069 biolink:NamedThing 7,8-dihydroxykynurenate 8,8a-dioxygenase activity Catalysis of the reaction: 7,8-dihydroxykynurenate + O(2) = 5-(3-carboxylato-3-oxoprop-1-en-1-yl)-4,6-dihydroxypyridine-2-carboxylate + H(+). got7fsn_ti 7,8-dihydroxykynurenate:oxygen 8,8alpha-oxidoreductase (decyclizing)|7,8-dihydroxykynurenate:oxygen 8,8a-oxidoreductase (decyclizing)|7,8-dihydroxykynurenate oxygenase activity|7,8-dihydroxykynurenate 8,8alpha-dioxygenase activity EC:1.13.11.10|MetaCyc:1.13.11.10-RXN|RHEA:23400|KEGG_REACTION:R03253 molecular_function owl:Class
GO:0018190 biolink:NamedThing protein octanoylation The modification of a protein amino acid by formation of an ester or amide with octanoic acid. got7fsn_ti protein amino acid octanoylation biological_process owl:Class
GO:0050019 biolink:NamedThing L-arabinitol 4-dehydrogenase activity Catalysis of the reaction: L-arabinitol + NAD(+) = L-xylulose + H(+) + NADH. got7fsn_ti EC:1.1.1.12|RHEA:16381|KEGG_REACTION:R01903|MetaCyc:L-ARABINITOL-4-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0071027 biolink:NamedThing nuclear RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus. got7fsn_ti nuclear aberrant RNA catabolic process|nuclear RNA quality control krc 2009-07-28T03:45:02Z biological_process owl:Class
GO:0071025 biolink:NamedThing RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs. got7fsn_ti aberrant RNA catabolic process|RNA quality control krc 2009-07-28T03:10:28Z biological_process owl:Class
GO:0090539 biolink:NamedThing peptide pheromone export by transmembrane transport The directed movement of a peptide pheromone across a membrane and out of a cell. got7fsn_ti peptide pheromone export by membrane transport tb 2013-02-11T15:44:51Z biological_process owl:Class
GO:0000770 biolink:NamedThing peptide pheromone export The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones. got7fsn_ti a-factor export GO:0007325 biological_process owl:Class
GO:0090503 biolink:NamedThing RNA phosphodiester bond hydrolysis, exonucleolytic The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. got7fsn_ti tb 2012-10-22T12:05:27Z biological_process owl:Class
GO:0090501 biolink:NamedThing RNA phosphodiester bond hydrolysis The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis. got7fsn_ti tb 2012-10-22T12:05:27Z biological_process owl:Class
GO:0034062 biolink:NamedThing 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end. got7fsn_ti ribonucleate nucleotidyltransferase activity|ribonucleic transcriptase activity|ribonucleic acid transcriptase activity|RNA transcriptase activity|ribonucleic polymerase activity|RNA polymerase activity|ribonucleic acid nucleotidyltransferase|C RNA formation factors|C ribonucleic acid formation factors|RNA nucleotidyltransferase activity|ribonucleic acid polymerase activity|ribonucleate polymerase activity|transcriptase Reactome:R-HSA-6786881|Reactome:R-HSA-5696807 molecular_function owl:Class
GO:0047243 biolink:NamedThing flavanone 7-O-beta-glucosyltransferase activity Catalysis of the reaction: a flavanone + UDP-D-glucose = a flavanone 7-O-beta-D-glucoside + UDP. got7fsn_ti naringenin 7-O-glucosyltransferase activity|hesperetin 7-O-glucosyl-transferase activity|UDPglucose:flavanone 7-O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-flavanone 7-O-glucosyltransferase activity|UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase activity MetaCyc:2.4.1.185-RXN|EC:2.4.1.185 molecular_function owl:Class
GO:0140591 biolink:NamedThing nuclear envelope budding The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20782 pg 2021-02-08T08:31:06Z biological_process owl:Class
GO:0051168 biolink:NamedThing nuclear export The directed movement of substances out of the nucleus. got7fsn_ti substance nuclear export|export from nucleus|nucleus export biological_process owl:Class
GO:0009428 biolink:NamedThing bacterial-type flagellum basal body, distal rod, P ring One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the peptidoglycan layer. got7fsn_ti flagellin-based flagellum basal body, distal rod, P ring|flagellar basal body, distal rod, P ring cellular_component owl:Class
GO:0061522 biolink:NamedThing 1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA. got7fsn_ti dph 2013-04-18T14:37:32Z molecular_function owl:Class
GO:0031127 biolink:NamedThing alpha-(1,2)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage. got7fsn_ti alpha-1,2-fucosyltransferase activity|alpha-(1->2)-fucosyltransferase activity molecular_function owl:Class
GO:0000987 biolink:NamedThing cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter. got7fsn_ti enhancer sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|enhancer binding|promoter proximal region sequence-specific DNA binding|cis-regulatory region binding|core promoter proximal region DNA binding|core promoter proximal region sequence-specific DNA binding bf 2010-02-26T10:17:00Z GO:0001159|GO:0001158|GO:0035326 molecular_function owl:Class
GO:0045967 biolink:NamedThing negative regulation of growth rate Any process that reduces the rate of growth of all or part of an organism. got7fsn_ti downregulation of growth rate|down-regulation of growth rate|inhibition of growth rate|down regulation of growth rate Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. biological_process owl:Class
GO:0040009 biolink:NamedThing regulation of growth rate Any process that modulates the rate of growth of all or part of an organism. got7fsn_ti Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. biological_process owl:Class
GO:0004515 biolink:NamedThing nicotinate-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+. got7fsn_ti ATP:nicotinate-nucleotide adenylyltransferase activity|deamido-NAD+ pyrophosphorylase activity|deamido-NAD(+) diphosphorylase activity|NaMN-ATase activity|deamido-NAD(+) pyrophosphorylase activity|nicotinate mononucleotide adenylyltransferase activity|nicotinic acid mononucleotide adenylyltransferase|deamidonicotinamide adenine dinucleotide pyrophosphorylase activity|ATP:nicotinate-ribonucleotide adenylyltransferase activity MetaCyc:NICONUCADENYLYLTRAN-RXN|Reactome:R-HSA-200512|Reactome:R-HSA-197235|RHEA:22860|Reactome:R-HSA-200474|EC:2.7.7.18 molecular_function owl:Class
GO:0047654 biolink:NamedThing alliin lyase activity Catalysis of the reaction: an S-alkyl-L-cysteine S-oxide = an alkyl sulfenate + 2-aminoacrylate. got7fsn_ti alliinase activity|alkylcysteine sulfoxide lyase activity|S-alkylcysteine sulfoxide lyase activity|alliin alkyl-sulfenate-lyase activity|cysteine sulfoxide lyase activity|cysteine sulphoxide lyase activity|S-alkyl-L-cysteine S-oxide alkyl-sulfenate-lyase (2-aminoacrylate-forming)|L-cysteine sulfoxide lyase activity MetaCyc:ALLIIN-LYASE-RXN|EC:4.4.1.4|RHEA:20141 molecular_function owl:Class
GO:0045211 biolink:NamedThing postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. got7fsn_ti post-synaptic membrane cellular_component owl:Class
GO:0097060 biolink:NamedThing synaptic membrane A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. got7fsn_ti pr 2011-06-07T11:22:09Z cellular_component owl:Class
GO:0102543 biolink:NamedThing epsilon-rhodomycinone methylesterase activity Catalysis of the reaction: epsilon-rhodomycinone + H2O <=> 15-demethoxy-epsilon-rhodomycinone + methanol + H+. got7fsn_ti MetaCyc:RXN-14865|EC:3.1.1.95 molecular_function owl:Class
GO:0016917 biolink:NamedThing GABA receptor activity Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. got7fsn_ti gamma-aminobutyric acid receptor activity|gamma-aminobutyrate binding|GABA binding|4-aminobutanoate receptor activity|gamma-aminobutyric acid binding|4-aminobutyrate receptor activity See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. molecular_function owl:Class
GO:0070460 biolink:NamedThing thyroid-stimulating hormone secretion The regulated release of thyroid-stimulating hormone, a peptide hormone that stimulates the activity of the thyroid gland, from secretory granules in the anterior pituitary. got7fsn_ti thyroid stimulating hormone secretion|TSH secretion biological_process owl:Class
GO:0102526 biolink:NamedThing 8-demethylnovobiocic acid C8-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 8-desmethylnovobiocic acid <=> S-adenosyl-L-homocysteine + novobiocic acid + H+. got7fsn_ti EC:2.1.1.284|RHEA:36651|MetaCyc:RXN-14543 molecular_function owl:Class
GO:0004858 biolink:NamedThing dUTP pyrophosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase. got7fsn_ti molecular_function owl:Class
GO:0042442 biolink:NamedThing melatonin catabolic process The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine). got7fsn_ti melatonin degradation|melatonin breakdown|melatonin catabolism GO:0042449 biological_process owl:Class
GO:0047333 biolink:NamedThing dihydrostreptomycin-6-phosphate 3'-alpha-kinase activity Catalysis of the reaction: ATP + dihydrostreptomycin 6-phosphate = ADP + dihydrostreptomycin 3'alpha,6-bisphosphate + 2 H(+). got7fsn_ti dihydrostreptomycin 6-phosphate kinase (phosphorylating)|dihydrostreptomycin-6-phosphate 3'alpha-kinase activity|ATP:dihydrostreptomycin-6-P 3'alpha-phosphotransferase activity|ATP:dihydrostreptomycin-6-phosphate 3'alpha-phosphotransferase activity EC:2.7.1.88|KEGG_REACTION:R03395|RHEA:16281|MetaCyc:2.7.1.88-RXN molecular_function owl:Class
GO:0034071 biolink:NamedThing aminoglycoside phosphotransferase activity Catalysis of the reaction: ATP + aminoglycoside = ADP + phosphoaminoglycoside. got7fsn_ti aminoglycoside kinase activity EC:2.7.1.- molecular_function owl:Class
GO:0097258 biolink:NamedThing 20-hydroxy-leukotriene B4 omega oxidase activity Catalysis of the reaction: 20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase]. got7fsn_ti 20-hydroxy-leukotriene B4 omega-oxidase activity|20-hydroxy-leukotriene B4 omega-oxidation pr 2012-03-07T03:37:53Z RHEA:48668|Reactome:R-HSA-2161745 molecular_function owl:Class
GO:0017184 biolink:NamedThing peptidyl-diphthamide catabolic process The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue. got7fsn_ti peptidyl-diphthamide degradation|peptidyl-diphthamide catabolism|peptidyl-diphthamide breakdown biological_process owl:Class
GO:0033883 biolink:NamedThing pyridoxal phosphatase activity Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate. got7fsn_ti PNP phosphatase activity|pyridoxal-5'-phosphate phosphohydrolase activity|PLP phosphatase activity|vitamin B6-phosphate phosphatase activity|vitamin B6 (pyridoxine) phosphatase activity MetaCyc:3.1.3.74-RXN|EC:3.1.3.74|RHEA:20533 molecular_function owl:Class
GO:0097432 biolink:NamedThing hippocampal pyramidal neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus. got7fsn_ti pr 2012-11-22T09:33:31Z biological_process owl:Class
GO:0021859 biolink:NamedThing pyramidal neuron differentiation The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron. got7fsn_ti projection neuron differentiation biological_process owl:Class
GO:0033990 biolink:NamedThing ectoine synthase activity Catalysis of the reaction: N(4)-acetyl-L-2,4-diaminobutyrate = ectoine + H(2)O. got7fsn_ti EctC|N4-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity|L-ectoine synthase activity|4-N-acetyl-L-2,4-diaminobutanoate hydro-lyase (L-ectoine-forming) activity|N-acetyldiaminobutyrate dehydratase activity|N-acetyldiaminobutanoate dehydratase activity MetaCyc:R103-RXN|RHEA:17281|EC:4.2.1.108|KEGG_REACTION:R06979 molecular_function owl:Class
GO:0072222 biolink:NamedThing metanephric early distal convoluted tubule development The process whose specific outcome is the progression of the metanephric early distal convoluted tubule over time, from its formation to the mature structure. The metanephric early distal convoluted tubule contains metanephric DCT cells and is vasopressin-insensitive. got7fsn_ti mah 2010-03-18T03:35:46Z biological_process owl:Class
GO:0072067 biolink:NamedThing early distal convoluted tubule development The process whose specific outcome is the progression of the early distal convoluted tubule over time, from its formation to the mature structure. The early distal convoluted tubule contains DCT cells and is vasopressin-insensitive. got7fsn_ti mah 2010-01-25T04:15:17Z biological_process owl:Class
GO:0047713 biolink:NamedThing galactitol 2-dehydrogenase activity Catalysis of the reaction: galactitol + NAD(+) = D-tagatose + H(+) + NADH. got7fsn_ti MetaCyc:GALACTITOL-2-DEHYDROGENASE-RXN|EC:1.1.1.16|KEGG_REACTION:R02928|RHEA:20685 molecular_function owl:Class
GO:0061273 biolink:NamedThing mesonephric distal tubule morphogenesis The process in which the anatomical structures of a mesonephric distal tubule are generated and organized. The mesonephric distal tubule is a mesonephric nephron tubule that begins at the macula densa and extends to the mesonephric connecting tubule. got7fsn_ti dph 2010-09-02T12:12:00Z biological_process owl:Class
GO:0075035 biolink:NamedThing appressorium maturation The process in which specialized features of the symbiont appressorium are acquired post initiation, to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti maturation of appressorium on or near host|appressorium maturation on or near host|maturation of symbiont appressorium on or near host biological_process owl:Class
GO:0098995 biolink:NamedThing disruption by virus of host envelope lipopolysaccharide during virus entry The breakdown of lipopolysaccharides in a host cell envelope during virus entry into a host cell. For example a phage entering a gram-negative bacterium may actively break down outer membrane lipopolysaccharides. got7fsn_ti degradation of host lipopolysaccharide during virus entry|disassembly by virus of outer membrane lipopolysaccharide during viral entry|degradation of host cell envelope lipopolysaccharide during viral entry VZ:3939 biological_process owl:Class
GO:0061899 biolink:NamedThing 11-cis-retinal 3,4-desaturase activity Catalysis of the reaction: 11-cis-retinal + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized [adrenodoxin]. got7fsn_ti dph 2017-06-12T15:03:57Z molecular_function owl:Class
GO:1990868 biolink:NamedThing response to chemokine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. got7fsn_ti sl 2015-09-25T16:37:00Z biological_process owl:Class
GO:1990172 biolink:NamedThing G protein-coupled receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a G protein-coupled receptor. got7fsn_ti G-protein coupled receptor catabolic process sp 2013-08-22T10:16:58Z biological_process owl:Class
GO:0098884 biolink:NamedThing postsynaptic neurotransmitter receptor internalization A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle. got7fsn_ti postsynaptic neurotransmitter receptor endocytosis https://github.com/geneontology/synapse/issues/230 biological_process owl:Class
GO:0008758 biolink:NamedThing UDP-2,3-diacylglucosamine hydrolase activity Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP. got7fsn_ti MetaCyc:LIPIDXSYNTHESIS-RXN|RHEA:25213 molecular_function owl:Class
GO:0046948 biolink:NamedThing hydroxylysine catabolic process The chemical reactions and pathways resulting in the breakdown of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. got7fsn_ti hydroxylysine degradation|hydroxylysine catabolism|hydroxylysine breakdown biological_process owl:Class
GO:0009068 biolink:NamedThing aspartate family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. got7fsn_ti aspartate family amino acid breakdown|aspartate family amino acid degradation|aspartate family amino acid catabolism biological_process owl:Class
GO:0097193 biolink:NamedThing intrinsic apoptotic signaling pathway A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). got7fsn_ti intrinsic apoptosis|induction of apoptosis by intracellular signals|intrinsic apoptotic signalling pathway|intrinsic apoptotic pathway|mitochondrial-mediated apoptotic pathway The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595. pr 2011-11-23T09:40:50Z GO:0008629 biological_process owl:Class
GO:0048101 biolink:NamedThing calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. The reaction is calmodulin and calcium-sensitive. got7fsn_ti calcium- and calmodulin-regulated cGMP-specific phosphodiesterase activity|calcium/calmodulin-regulated cGMP-specific phosphodiesterase activity|calcium- and calmodulin-regulated cGMP phosphodiesterase activity|calcium- and calmodulin-regulated cyclic-GMP phosphodiesterase activity molecular_function owl:Class
GO:0047555 biolink:NamedThing 3',5'-cyclic-GMP phosphodiesterase activity Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. got7fsn_ti guanosine cyclic 3',5'-phosphate phosphodiesterase activity|cyclic guanosine 3',5'-monophosphate phosphodiesterase activity|cyclic 3',5'-GMP phosphodiesterase activity|cyclic GMP phosphodiesterase activity|cGMP-PDE|3',5'-cyclic-GMP 5'-nucleotidohydrolase activity|cGMP phosphodiesterase activity|cGMP-specific phosphodiesterase activity|cyclic guanosine 3',5'-phosphate phosphodiesterase activity|3',5' cyclic-GMP phosphodiesterase activity GO:0004116 MetaCyc:35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN|Reactome:R-HSA-74059|EC:3.1.4.35|RHEA:16957|Reactome:R-HSA-4086392|Reactome:R-HSA-418456 molecular_function owl:Class
GO:0030787 biolink:NamedThing inositol 4-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity|myo-inositol 6-O-methyltransferase activity|myo-inositol 4-O-methyltransferase activity|S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity MetaCyc:2.1.1.129-RXN|RHEA:23248|EC:2.1.1.129|KEGG_REACTION:R01190 molecular_function owl:Class
GO:0033409 biolink:NamedThing UAU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UAU codon. got7fsn_ti tyrosine tRNA|TAT codon-amino acid adaptor activity Note that in the standard genetic code, TAT codes for tyrosine. molecular_function owl:Class
GO:0071840 biolink:NamedThing cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. got7fsn_ti cellular component organisation or biogenesis at cellular level|cellular component organization or biogenesis at cellular level|cellular component organisation or biogenesis mah 2010-09-10T01:39:16Z GO:0071841 biological_process owl:Class
GO:0033904 biolink:NamedThing dextranase activity Catalysis of the endohydrolysis of 1,6-alpha-D-glucosidic linkages in dextran. got7fsn_ti DL 2|alpha-D-1,6-glucan-6-glucanohydrolase activity|1,6-alpha-D-glucan 6-glucanohydrolase activity|alpha-1,6-glucan-6-glucanohydrolase activity|dextran hydrolase activity|dextranase DL 2 activity|endodextranase activity|endo-dextranase activity EC:3.2.1.11|MetaCyc:3.2.1.11-RXN molecular_function owl:Class
GO:0043729 biolink:NamedThing 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate. got7fsn_ti molecular_function owl:Class
GO:0044165 biolink:NamedThing host cell endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). got7fsn_ti host endoplasmic reticulum jl 2009-09-04T11:08:09Z cellular_component owl:Class
GO:0060060 biolink:NamedThing post-embryonic retina morphogenesis in camera-type eye The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage. got7fsn_ti biological_process owl:Class
GO:0019907 biolink:NamedThing cyclin-dependent protein kinase activating kinase holoenzyme complex A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. got7fsn_ti CDK-activating kinase complex|CAK complex cellular_component owl:Class
GO:0018996 biolink:NamedThing molting cycle, collagen and cuticulin-based cuticle The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans. got7fsn_ti collagen and cuticulin-based cuticle molting cycle biological_process owl:Class
GO:0042303 biolink:NamedThing molting cycle The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc. got7fsn_ti biological_process owl:Class
GO:1902426 biolink:NamedThing deactivation of mitotic spindle assembly checkpoint A positive regulation of the mitotic metaphase/anaphase transition that results from deactivation of the mitotic spindle assembly checkpoint. got7fsn_ti inhibition of mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic cell cycle spindle assembly checkpoint|downregulation of Mad2-dependent checkpoint|down regulation of mitotic cell cycle spindle assembly checkpoint|down regulation of mitotic spindle assembly checkpoint|down-regulation of mitotic spindle assembly checkpoint|negative regulation of mitotic spindle assembly checkpoint|down-regulation of Mad2-dependent checkpoint|inhibition of mitotic spindle assembly checkpoint|down regulation of Mad2-dependent checkpoint|inhibition of Mad2-dependent checkpoint|downregulation of mitotic cell cycle spindle assembly checkpoint|negative regulation of Mad2-dependent checkpoint|downregulation of mitotic spindle assembly checkpoint|mitotic spindle assembly deactivation|down-regulation of mitotic cell cycle spindle assembly checkpoint|mitotic spindle assembly checkpoint silencing A mitotic spindle assembly checkpoint is either activated or switched off; no other means of reducing the frequency, rate or extent of this process are currently known. dph 2013-09-20T18:42:07Z biological_process owl:Class
GO:0045931 biolink:NamedThing positive regulation of mitotic cell cycle Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. got7fsn_ti up-regulation of progression through mitotic cell cycle|positive regulation of progression through mitotic cell cycle|stimulation of progression through mitotic cell cycle|activation of progression through mitotic cell cycle|up regulation of progression through mitotic cell cycle|positive regulation of mitotic cell cycle progression|upregulation of progression through mitotic cell cycle biological_process owl:Class
GO:0102367 biolink:NamedThing 2-alpha-hydroxytaxusin 7-beta-hydroxylase activity Catalysis of the reaction: 2alpha-hydroxytaxusin + NADPH + O2 + H+ <=> 2alpha, 7beta-dihydroxytaxusin + NADP + H2O. got7fsn_ti MetaCyc:RXN-13488 molecular_function owl:Class
GO:0048758 biolink:NamedThing companion cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member. got7fsn_ti biological_process owl:Class
GO:0048760 biolink:NamedThing plant parenchymal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure. got7fsn_ti parenchymal cell differentiation biological_process owl:Class
GO:0004805 biolink:NamedThing trehalose-phosphatase activity Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate. got7fsn_ti trehalose 6-phosphatase activity|trehalose-6-phosphate phosphohydrolase activity|trehalose 6-phosphate phosphatase activity|trehalose phosphatase activity EC:3.1.3.12|MetaCyc:TREHALOSEPHOSPHA-RXN|RHEA:23420 molecular_function owl:Class
GO:0044576 biolink:NamedThing pentose catabolic process to ethanol The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol. got7fsn_ti pentose catabolism to ethanol jl 2012-04-19T03:46:37Z biological_process owl:Class
GO:0006115 biolink:NamedThing ethanol biosynthetic process The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. got7fsn_ti ethanol anabolism|ethanol formation|ethanol biosynthesis|ethanol synthesis biological_process owl:Class
GO:0070549 biolink:NamedThing negative regulation of translation involved in RNA interference A process of negative regulation of translation that is mediated by the association of small interfering RNAs (siRNAs) with a cognate target mRNA. got7fsn_ti RNA interference, negative regulation of translation|inhibition of translation involved in RNA interference|down-regulation of translation involved in RNA interference|down regulation of translation involved in RNA interference|downregulation of translation involved in RNA interference biological_process owl:Class
GO:0040033 biolink:NamedThing negative regulation of translation, ncRNA-mediated Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein. got7fsn_ti inhibition of mRNA translation, ncRNA-mediated|downregulation of mRNA translation, ncRNA-mediated|down-regulation of mRNA translation, ncRNA-mediated|down regulation of mRNA translation, ncRNA-mediated biological_process owl:Class
GO:0022616 biolink:NamedThing DNA strand elongation The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand. got7fsn_ti https://github.com/geneontology/go-ontology/issues/12633 biological_process owl:Class
GO:0032632 biolink:NamedThing interleukin-3 production The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-3 production|interleukin-3 secretion|interleukin-3 biosynthetic process GO:0042223|GO:0072601 biological_process owl:Class
GO:0120282 biolink:NamedThing autolysosome lumen The volume that is enclosed within the autolysosome single-membrane. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20239 krc 2020-11-17T02:53:51Z cellular_component owl:Class
GO:0005775 biolink:NamedThing vacuolar lumen The volume enclosed within the vacuolar membrane. got7fsn_ti cellular_component owl:Class
GO:0004427 biolink:NamedThing inorganic diphosphatase activity Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate. got7fsn_ti pyrophosphate phosphohydrolase activity|diphosphate phosphohydrolase activity|inorganic pyrophosphatase activity Reactome:R-HSA-71732|Reactome:R-HSA-6788912|Reactome:R-HSA-449937|EC:3.6.1.1|MetaCyc:INORGPYROPHOSPHAT-RXN|RHEA:24576|KEGG_REACTION:R00004 molecular_function owl:Class
GO:0102489 biolink:NamedThing GTP phosphohydrolase activity Catalysis of the reaction: GTP + 2 H2O = GMP + 2 hydrogenphosphate + 2 H+. got7fsn_ti EC:3.6.1.5|MetaCyc:RXN-14201 molecular_function owl:Class
GO:1990587 biolink:NamedThing FtsQBL complex A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ. got7fsn_ti FtsB-FtsL-FtsQ complex An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction). bhm 2014-12-15T09:25:09Z cellular_component owl:Class
GO:1990586 biolink:NamedThing divisome complex A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells. got7fsn_ti bhm 2014-12-15T09:13:38Z cellular_component owl:Class
GO:0071335 biolink:NamedThing hair follicle cell proliferation The multiplication or reproduction of hair follicle cells, resulting in the expansion of a cell population. got7fsn_ti mah 2009-12-11T10:49:53Z biological_process owl:Class
GO:0047721 biolink:NamedThing indoleacetate-lysine synthetase activity Catalysis of the reaction: (indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + 2 H(+) + phosphate. got7fsn_ti (indol-3-yl)acetate:L-lysine ligase (ADP-forming)|indoleacetate:L-lysine ligase (ADP-forming)|N-(indole-3-acetyl)-L-lysine synthetase activity|indoleacetate-lysine ligase activity|IAA-lysine synthetase activity KEGG_REACTION:R03095|EC:6.3.2.20|MetaCyc:INDOLEACETATE--LYSINE-LIGASE-RXN|RHEA:14857 molecular_function owl:Class
GO:0010279 biolink:NamedThing indole-3-acetic acid amido synthetase activity Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate. got7fsn_ti IAA amino acid conjugate synthetase activity|IAA amido synthetase activity|IAA amino acid synthetase activity molecular_function owl:Class
GO:0016532 biolink:NamedThing superoxide dismutase copper chaperone activity A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity. got7fsn_ti See also the molecular function term 'superoxide dismutase activity ; GO:0004784'. molecular_function owl:Class
GO:0016531 biolink:NamedThing copper chaperone activity Directly binding to and delivering copper ions to a target protein. got7fsn_ti molecular_function owl:Class
GO:0033857 biolink:NamedThing diphosphoinositol-pentakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate. got7fsn_ti PPIP5K2|PP-InsP5 kinase activity|PPIP5K|VIP1|VIP2|ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase activity|PP-IP5 kinase activity|PPIP5K1 EC:2.7.4.24 molecular_function owl:Class
GO:0004693 biolink:NamedThing cyclin-dependent protein serine/threonine kinase activity Cyclin-dependent catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. got7fsn_ti cyclin-dependent protein kinase, intrinsic catalyst activity|cyclin-A associated kinase activity|D-type cyclin kinase activity|cyclin-dependent kinase activity|neuronal cdc2-like kinase activity|Cdk-activating protein kinase activity|cyclin D-cdk6 kinase activity|CDK activity|cyclin-dependent kinase 6 activity|cyclin-dependent kinase-2 activity|cdk-activating kinase activity|cdc2 kinase activity|cyclin-dependent kinase-4 activity|ATP:cyclin phosphotransferase activity|cyclin E kinase activity|CDK, catalytic subunit activity|cyclin D-dependent kinase activity|cyclin-dependent protein kinase activity|CDK This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). GO:0016537 Reactome:R-HSA-6805109|Reactome:R-HSA-69227|Reactome:R-HSA-69756|Reactome:R-HSA-2430533|Reactome:R-HSA-180047|Reactome:R-HSA-187959|Reactome:R-HSA-5244669|Reactome:R-HSA-187520|Reactome:R-HSA-174122|Reactome:R-HSA-9008412|Reactome:R-HSA-5195402|MetaCyc:2.7.11.22-RXN|Reactome:R-HSA-2468287|Reactome:R-HSA-69754|Reactome:R-HSA-4086410|Reactome:R-HSA-9624800|Reactome:R-HSA-2984220|Reactome:R-HSA-69005|Reactome:R-HSA-1226095|Reactome:R-HSA-2990882|Reactome:R-HSA-2172183|Reactome:R-HSA-6793661|Reactome:R-HSA-174132|Reactome:R-HSA-68944|Reactome:R-HSA-1226094|Reactome:R-HSA-6797606|Reactome:R-HSA-2245218|Reactome:R-HSA-187948|Reactome:R-HSA-9686521|Reactome:R-HSA-5692755|Reactome:R-HSA-188390|Reactome:R-HSA-380278|Reactome:R-HSA-1912391|Reactome:R-HSA-2220971|Reactome:R-HSA-187916|Reactome:R-HSA-174079|Reactome:R-HSA-4088024|Reactome:R-HSA-2468293|EC:2.7.11.22|Reactome:R-HSA-2294600|Reactome:R-HSA-2514854|Reactome:R-HSA-3788705|Reactome:R-HSA-174251|Reactome:R-HSA-9009282 molecular_function owl:Class
GO:0097472 biolink:NamedThing cyclin-dependent protein kinase activity Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. got7fsn_ti This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). pr 2013-03-06T13:46:04Z molecular_function owl:Class
GO:0018599 biolink:NamedThing 2-hydroxyisobutyrate 3-monooxygenase activity Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate. got7fsn_ti UM-BBD_reactionID:r0619 molecular_function owl:Class
GO:0072402 biolink:NamedThing response to DNA integrity checkpoint signaling A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling. got7fsn_ti response to signal involved in DNA integrity checkpoint|DNA integrity checkpoint effector process mah 2010-12-08T03:32:17Z biological_process owl:Class
GO:0045905 biolink:NamedThing positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. got7fsn_ti activation of translational termination|up-regulation of translational termination|upregulation of translational termination|stimulation of translational termination|up regulation of translational termination biological_process owl:Class
GO:0007529 biolink:NamedThing establishment of synaptic specificity at neuromuscular junction The biological process in which a synapse between a motor neuron and a muscle is initially formed. got7fsn_ti biological_process owl:Class
GO:0034990 biolink:NamedThing nuclear mitotic cohesin complex A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. got7fsn_ti Note that this term should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i. e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. cellular_component owl:Class
GO:0000798 biolink:NamedThing nuclear cohesin complex A cohesin complex required for cohesion between sister chromatids that remain in the nucleus. got7fsn_ti Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. cellular_component owl:Class
GO:0071597 biolink:NamedThing cellular birth scar Crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation. got7fsn_ti mah 2010-02-02T02:42:44Z cellular_component owl:Class
GO:0021675 biolink:NamedThing nerve development The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0030685 biolink:NamedThing nucleolar preribosome Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis. got7fsn_ti cellular_component owl:Class
GO:0006186 biolink:NamedThing dGDP phosphorylation The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP. got7fsn_ti biological_process owl:Class
GO:0009216 biolink:NamedThing purine deoxyribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar. got7fsn_ti purine deoxyribonucleoside triphosphate biosynthesis|purine deoxyribonucleoside triphosphate formation|purine deoxyribonucleoside triphosphate anabolism|purine deoxyribonucleoside triphosphate synthesis biological_process owl:Class
GO:0031209 biolink:NamedThing SCAR complex A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction. got7fsn_ti WAVE complex|WAVE regulatory complex|WRC cellular_component owl:Class
GO:0009927 biolink:NamedThing histidine phosphotransfer kinase activity Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator. got7fsn_ti https://github.com/geneontology/go-ontology/issues/15611 molecular_function owl:Class
GO:0060089 biolink:NamedThing molecular transducer activity A compound molecular function in which an effector function is controlled by one or more regulatory components. got7fsn_ti molecular_function owl:Class
GO:0000814 biolink:NamedThing ESCRT II complex An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes. got7fsn_ti endosomal sorting complex required for transport cellular_component owl:Class
GO:0036452 biolink:NamedThing ESCRT complex An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes. got7fsn_ti endosomal sorting complex required for transport bf 2013-11-06T16:25:52Z Wikipedia:ESCRT cellular_component owl:Class
GO:0050816 biolink:NamedThing phosphothreonine residue binding Binding to a phosphorylated threonine residue within a protein. got7fsn_ti phosphothreonine binding molecular_function owl:Class
GO:0045309 biolink:NamedThing protein phosphorylated amino acid binding Binding to a phosphorylated amino acid residue within a protein. got7fsn_ti phosphoprotein amino acid binding molecular_function owl:Class
GO:0004451 biolink:NamedThing isocitrate lyase activity Catalysis of the reaction: isocitrate = glyoxylate + succinate. got7fsn_ti threo-DS-isocitrate glyoxylate-lyase activity|isocitrate glyoxylate-lyase activity|isocitratase activity|isocitrate glyoxylate-lyase (succinate-forming)|ICL activity|isocitritase activity|isocitrase activity MetaCyc:ISOCIT-CLEAV-RXN|RHEA:13245|KEGG_REACTION:R00479|EC:4.1.3.1 molecular_function owl:Class
GO:0032923 biolink:NamedThing organic phosphonate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. got7fsn_ti organophosphonate biosynthetic process biological_process owl:Class
GO:0042816 biolink:NamedThing vitamin B6 metabolic process The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. got7fsn_ti vitamin B6 metabolism biological_process owl:Class
GO:0048072 biolink:NamedThing compound eye pigmentation Establishment of a pattern of pigment in the compound eye. got7fsn_ti biological_process owl:Class
GO:0047157 biolink:NamedThing myelin-proteolipid O-palmitoyltransferase activity Catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA. got7fsn_ti palmitoyl-CoA:[myelin-proteolipid] O-palmitoyltransferase activity|myelin PLP acyltransferase activity|acyl-protein synthase activity|[myelin-proteolipid] O-palmitoyltransferase activity https://github.com/geneontology/go-ontology/issues/21319 EC:2.3.1.100|MetaCyc:2.3.1.100-RXN molecular_function owl:Class
GO:0032609 biolink:NamedThing interferon-gamma production The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. got7fsn_ti interferon-gamma secretion|IFNG production|type II IFN production|interferon-gamma biosynthetic process|type II interferon production GO:0072643|GO:0042095 biological_process owl:Class
GO:0061059 biolink:NamedThing positive regulation of peptidoglycan recognition protein signaling pathway Any process that increases the rate, frequency, or extent of the peptidoglycan recognition protein signaling pathway. got7fsn_ti positive regulation of peptidoglycan recognition protein signalling pathway dph 2010-03-02T12:37:44Z biological_process owl:Class
GO:0002833 biolink:NamedThing positive regulation of response to biotic stimulus Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus. got7fsn_ti up regulation of response to biotic stimulus|up-regulation of response to biotic stimulus|upregulation of response to biotic stimulus|activation of response to biotic stimulus|stimulation of response to biotic stimulus Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0031820 biolink:NamedThing P2Y11 nucleotide receptor binding Binding to a P2Y11 nucleotide receptor. got7fsn_ti P2Y11 nucleotide receptor ligand molecular_function owl:Class
GO:0071038 biolink:NamedThing nuclear polyadenylation-dependent tRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA. got7fsn_ti nuclear poly(A)-dependent tRNA catabolic process krc 2009-07-29T01:08:14Z biological_process owl:Class
GO:0106354 biolink:NamedThing tRNA surveillance The set of processes involved in identifying and degrading defective or aberrant tRNAs. got7fsn_ti hjd 2021-01-27T16:29:46Z biological_process owl:Class
GO:0048148 biolink:NamedThing behavioral response to cocaine Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus. got7fsn_ti behavioural response to cocaine biological_process owl:Class
GO:0051601 biolink:NamedThing exocyst localization Any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. got7fsn_ti establishment and maintenance of exocyst localization|exocyst localisation biological_process owl:Class
GO:0014864 biolink:NamedThing detection of muscle activity The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0014865 biolink:NamedThing detection of activity The series of events in which an activity stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0003413 biolink:NamedThing chondrocyte differentiation involved in endochondral bone morphogenesis The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage. got7fsn_ti dph 2009-12-22T08:39:58Z biological_process owl:Class
GO:0033840 biolink:NamedThing NDP-glucose-starch glucosyltransferase activity Catalysis of the reaction: NDP-glucose + (1,4-alpha-D-glucosyl)n = NDP + (1,4-alpha-D-glucosyl)n+1. got7fsn_ti waxy protein|GBSS|NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|granule-bound starch synthase activity|starch synthase II activity|NDPglucose-starch glucosyltransferase activity|GBSSI|granule-bound starch synthase II activity|GBSSII|starch granule-bound nucleoside diphosphate glucose-starch glucosyltransferase activity|granule-bound starch synthase I activity MetaCyc:2.4.1.242-RXN|EC:2.4.1.242|RHEA:15873 molecular_function owl:Class
GO:0004934 biolink:NamedThing mating-type alpha-factor pheromone receptor activity Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity. got7fsn_ti class D G-protein-coupled receptor activity|class D G protein coupled receptor activity|class D G-protein coupled receptor activity|class D GPCR activity molecular_function owl:Class
GO:0036318 biolink:NamedThing peptide pheromone receptor activity Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity. got7fsn_ti bf 2012-08-30T16:45:14Z molecular_function owl:Class
GO:0048204 biolink:NamedThing vesicle targeting, inter-Golgi cisterna The process in which vesicles are directed to specific destination membranes during transport from one Golgi cisterna to another. got7fsn_ti inter-Golgi cisterna targeting biological_process owl:Class
GO:0061693 biolink:NamedThing alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine. got7fsn_ti dph 2015-05-06T10:04:04Z MetaCyc:RXN0-6732|EC:2.7.8.37|RHEA:34679 molecular_function owl:Class
GO:0009716 biolink:NamedThing flavonoid phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. got7fsn_ti flavonoid phytoalexin biosynthesis|flavonoid phytoalexin synthesis|flavonoid phytoalexin formation|flavonoid phytoalexin anabolism biological_process owl:Class
GO:0052315 biolink:NamedThing phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of phytoalexins, any of a range of substances produced by plants as part of their defense response. got7fsn_ti phytoalexin biosynthesis biological_process owl:Class
GO:0018658 biolink:NamedThing salicylate 1-monooxygenase activity Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2. got7fsn_ti salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)|salicylic hydroxylase activity|salicylate hydroxylase activity|salicylate 1-hydroxylase activity|salicylate hydroxylase (decarboxylating)|salicylate monooxygenase activity RHEA:11004|EC:1.14.13.1|UM-BBD_enzymeID:e0149|MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0006876 biolink:NamedThing cellular cadmium ion homeostasis Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell. got7fsn_ti cadmium homeostasis biological_process owl:Class
GO:0008109 biolink:NamedThing N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. got7fsn_ti uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase|N-acetylglucosaminyltransferase activity|UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity|galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity MetaCyc:2.4.1.150-RXN|RHEA:17413|EC:2.4.1.150 molecular_function owl:Class
GO:0006525 biolink:NamedThing arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. got7fsn_ti arginine metabolism Wikipedia:Arginine biological_process owl:Class
GO:0009064 biolink:NamedThing glutamine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. got7fsn_ti glutamine family amino acid metabolism biological_process owl:Class
GO:0070824 biolink:NamedThing SHREC complex A histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures. got7fsn_ti Snf2/HDAC containing repressor complex|Snf2/Hdac repressive complex https://github.com/geneontology/go-ontology/issues/20938 mah 2009-07-20T05:02:12Z cellular_component owl:Class
GO:0030476 biolink:NamedThing ascospore wall assembly The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti spore wall assembly GO:0007152 biological_process owl:Class
GO:0071940 biolink:NamedThing fungal-type cell wall assembly The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall. got7fsn_ti fungal-type cell wall formation mah 2010-09-30T04:59:36Z biological_process owl:Class
GO:0045066 biolink:NamedThing regulatory T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types. got7fsn_ti regulatory T-lymphocyte differentiation|suppressor T lymphocyte differentiation|suppressor T-cell differentiation|regulatory T lymphocyte differentiation|suppressor T cell differentiation|suppressor T-lymphocyte differentiation|regulatory T-cell differentiation|regulatory T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0036171 biolink:NamedThing filamentous growth of a population of unicellular organisms in response to chemical stimulus The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus. got7fsn_ti bf 2012-03-27T03:53:28Z biological_process owl:Class
GO:0047453 biolink:NamedThing ATP-dependent NAD(P)H-hydrate dehydratase activity Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ATP = ADP + 3 H(+) + NADH + phosphate. got7fsn_ti (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ATP-hydrolysing; NADH-forming)|(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing)|ATP-dependent H4NAD(P)OH dehydratase activity|ATP-dependent H(4)NAD(P)OH dehydratase activity|reduced nicotinamide adenine dinucleotide hydrate dehydratase activity RHEA:19017|KEGG_REACTION:R00129|Reactome:R-HSA-6806967|EC:4.2.1.93|MetaCyc:4.2.1.93-RXN molecular_function owl:Class
GO:0030682 biolink:NamedThing mitigation of host defenses by symbiont A process by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti evasion or tolerance of defense response of other organism during symbiotic interaction|avoidance of defenses of other organism involved in symbiotic interaction|evasion or tolerance of host defense response|evasion or tolerance of defenses of other organism during symbiotic interaction|evasion or tolerance of defenses of other organism|evasion or tolerance of host defenses|evasion or tolerance of defenses of other organism involved in symbiotic interaction|evasion of host defence response|evasion of other organism defence response|avoidance of host defences|evasion or tolerance of defense response of other organism involved in symbiotic interaction|avoidance of defenses of other organism during symbiotic interaction|avoidance of host defenses GO:0051834|GO:0051832|GO:0051807|GO:0044415|GO:0044413 biological_process owl:Class
GO:0061829 biolink:NamedThing basal tubulobulbar complex Actin-based structures involved in establishing the blood-testis barrier of the Sertoli cell. got7fsn_ti basal TBC dph 2017-01-15T10:42:31Z cellular_component owl:Class
GO:0045861 biolink:NamedThing negative regulation of proteolysis Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. got7fsn_ti inhibition of proteolysis|negative regulation of peptidolysis|down-regulation of proteolysis|downregulation of proteolysis|down regulation of proteolysis biological_process owl:Class
GO:0032269 biolink:NamedThing negative regulation of cellular protein metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. got7fsn_ti down regulation of cellular protein metabolic process|inhibition of cellular protein metabolic process|negative regulation of cellular protein metabolism|down-regulation of cellular protein metabolic process|downregulation of cellular protein metabolic process biological_process owl:Class
GO:0016157 biolink:NamedThing sucrose synthase activity Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. got7fsn_ti uridine diphosphoglucose-fructose glucosyltransferase activity|UDP-glucose-fructose glucosyltransferase activity|sucrose synthetase activity|sucrose-UDP glucosyltransferase activity|UDPglucose-fructose glucosyltransferase activity|sucrose-uridine diphosphate glucosyltransferase activity|NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity EC:2.4.1.13|MetaCyc:SUCROSE-SYNTHASE-RXN molecular_function owl:Class
GO:0009087 biolink:NamedThing methionine catabolic process The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. got7fsn_ti methionine breakdown|methionine catabolism|methionine degradation UM-BBD_pathwayID:met biological_process owl:Class
GO:0001604 biolink:NamedThing urotensin II receptor activity Combining with urotensin II to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0047644 biolink:NamedThing alizarin 2-beta-glucosyltransferase activity Catalysis of the reaction: alizarin + UDP-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + H(+) + UDP. got7fsn_ti alizarin 2-b-glucosyltransferase activity|UDPglucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyl-transferase activity|uridine diphosphoglucose-alizarin glucosyltransferase activity|UDP-glucose:1,2-dihydroxy-9,10-anthraquinone 2-O-beta-D-glucosyltransferase activity EC:2.4.1.103|MetaCyc:ALIZARIN-2-BETA-GLUCOSYLTRANSFERASE-RXN|KEGG_REACTION:R03573|RHEA:20677 molecular_function owl:Class
GO:0048808 biolink:NamedThing male genitalia morphogenesis The process in which the anatomical structures of male genitalia are generated and organized. got7fsn_ti male genital morphogenesis biological_process owl:Class
GO:0033037 biolink:NamedThing polysaccharide localization Any process in which a polysaccharide is transported to, or maintained in, a specific location. got7fsn_ti polysaccharide localisation biological_process owl:Class
GO:0015104 biolink:NamedThing antimonite transmembrane transporter activity Enables the transfer of antimonite from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0043624 biolink:NamedThing cellular protein complex disassembly The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups. got7fsn_ti biological_process owl:Class
GO:0032984 biolink:NamedThing protein-containing complex disassembly The disaggregation of a protein-containing macromolecular complex into its constituent components. got7fsn_ti cellular macromolecule complex disassembly|macromolecule complex disassembly|protein complex disassembly GO:0034623|GO:0043241 biological_process owl:Class
GO:0106380 biolink:NamedThing purine ribonucleotide salvage Any process which produces a purine ribonucleotide from derivatives of it, without de novo synthesis. got7fsn_ti hjd 2021-06-11T14:06:34Z biological_process owl:Class
GO:0033059 biolink:NamedThing cellular pigmentation The deposition or aggregation of coloring matter in a cell. got7fsn_ti biological_process owl:Class
GO:0047919 biolink:NamedThing GDP-mannose 6-dehydrogenase activity Catalysis of the reaction: GDP-alpha-D-mannose + H(2)O + 2 NAD(+) = GDP-D-mannuronate + 3 H(+) + 2 NADH. got7fsn_ti GDPmannose 6-dehydrogenase activity|guanosine diphospho-D-mannose dehydrogenase activity|GDP-D-mannose:NAD+ 6-oxidoreductase activity|GDP mannose dehydrogenase activity|guanosine diphosphomannose dehydrogenase activity RHEA:21728|EC:1.1.1.132|KEGG_REACTION:R00880|MetaCyc:GDP-MANNOSE-6-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0050977 biolink:NamedThing magnetoreception by sensory perception of chemical stimulus The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli. got7fsn_ti magnetoreception, sensory perception of chemical stimulus|magnetoreception by chemical stimulus|magnetoreception, using chemical stimulus|magnetoreception through chemical stimulus biological_process owl:Class
GO:0042799 biolink:NamedThing histone methyltransferase activity (H4-K20 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein. got7fsn_ti histone lysine N-methyltransferase activity (H4-K20 specific)|histone H4 lysine 20-specific methyltransferase activity|histone methylase activity (H4-K20 specific) Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies. Reactome:R-HSA-2301205|Reactome:R-HSA-5682965 molecular_function owl:Class
GO:0018024 biolink:NamedThing histone-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. got7fsn_ti S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity|protein methyltransferase II activity|histone-lysine N-methylase activity|protein (lysine) methyltransferase activity|protein methylase III activity|S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity|protein methylase 3 activity|histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity Reactome:R-HSA-5634729|Reactome:R-HSA-5638332|Reactome:R-HSA-5638141|Reactome:R-HSA-5638157|Reactome:R-HSA-3788745|Reactome:R-HSA-5159245|Reactome:R-HSA-5649799|RESID:AA0075|Reactome:R-HSA-5634750|Reactome:R-HSA-5651657|Reactome:R-HSA-5638333|RESID:AA0076|Reactome:R-HSA-4827382|Reactome:R-HSA-5423038|RHEA:10024|Reactome:R-HSA-5244692|Reactome:R-HSA-5637686|EC:2.1.1.354|Reactome:R-HSA-3788748|Reactome:R-HSA-5649800|Reactome:R-HSA-5649801|MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN|Reactome:R-HSA-4827383|RESID:AA0074|Reactome:R-HSA-5634802|Reactome:R-HSA-5649802|Reactome:R-HSA-5651654|Reactome:R-HSA-5649764 molecular_function owl:Class
GO:0046286 biolink:NamedThing flavonoid phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection. got7fsn_ti flavonoid phytoalexin degradation|flavonoid phytoalexin catabolism|flavonoid phytoalexin breakdown biological_process owl:Class
GO:0052316 biolink:NamedThing phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of phytoalexins, any of a range of substances produced by plants as part of their defense response. got7fsn_ti phytoalexin catabolism biological_process owl:Class
GO:0008009 biolink:NamedThing chemokine activity The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. got7fsn_ti molecular_function owl:Class
GO:0005125 biolink:NamedThing cytokine activity The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. got7fsn_ti paracrine activity|autocrine activity https://github.com/geneontology/go-ontology/issues/19116 molecular_function owl:Class
GO:0061790 biolink:NamedThing dense core granule docking The initial attachment of a dense core granule membrane to the plasma membrane. got7fsn_ti dph 2016-09-08T15:51:49Z biological_process owl:Class
GO:0006904 biolink:NamedThing vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. got7fsn_ti vesicle docking during exocytosis biological_process owl:Class
GO:0102484 biolink:NamedThing esculetin glucosyltransferase activity Catalysis of the reaction: esculetin + UDP-alpha-D-glucose(2-) <=> esculin + UDP(3-) + H+. got7fsn_ti MetaCyc:RXN-14182 molecular_function owl:Class
GO:0047655 biolink:NamedThing allyl-alcohol dehydrogenase activity Catalysis of the reaction: allyl alcohol + NADP(+) = acrolein + H(+) + NADPH. got7fsn_ti allyl-alcohol:NADP+ oxidoreductase activity RHEA:12168|MetaCyc:ALLYL-ALCOHOL-DEHYDROGENASE-RXN|EC:1.1.1.54|KEGG_REACTION:R03572 molecular_function owl:Class
GO:0102794 biolink:NamedThing cinnamaldehyde:oxygen oxidoreductase activity Catalysis of the reaction: cinnamaldehyde + O2 + H2O = H+ + trans-cinnamate + hydrogen peroxide. got7fsn_ti EC:1.2.3.9|MetaCyc:RXN-8089 molecular_function owl:Class
GO:0007476 biolink:NamedThing imaginal disc-derived wing morphogenesis The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying. got7fsn_ti wing morphogenesis biological_process owl:Class
GO:0000213 biolink:NamedThing tRNA-intron endonuclease activity Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. got7fsn_ti tRNA-intron endoribonuclease activity|splicing endonuclease activity|tRNA splicing endonuclease activity|tRNA-splicing endonuclease activity|transfer ribonucleate intron endoribonuclease activity|transfer splicing endonuclease activity|tRNATRPintron endonuclease activity MetaCyc:3.1.27.9-RXN|EC:3.1.27.9 molecular_function owl:Class
GO:0047863 biolink:NamedThing dimethylallylcistransferase activity Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + neryl diphosphate. got7fsn_ti neryl-diphosphate synthase activity|dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallylcistransferase activity MetaCyc:DIMETHYLALLYLCISTRANSFERASE-RXN|EC:2.5.1.28|KEGG_REACTION:R01659|RHEA:11328 molecular_function owl:Class
GO:0002242 biolink:NamedThing defense response to parasitic plant Reactions triggered in response to the presence of a parasitic plant that act to protect an organism. got7fsn_ti biological_process owl:Class
GO:0005981 biolink:NamedThing regulation of glycogen catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. got7fsn_ti regulation of glycogen breakdown|regulation of glycogen catabolism|regulation of glycogen degradation|regulation of glycogenolysis biological_process owl:Class
GO:0032035 biolink:NamedThing myosin II tail binding Binding to the tail region of a myosin II heavy chain. got7fsn_ti molecular_function owl:Class
GO:0032029 biolink:NamedThing myosin tail binding Binding to the tail region of a myosin heavy chain. got7fsn_ti molecular_function owl:Class
GO:0045163 biolink:NamedThing clustering of voltage-gated potassium channels The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode. got7fsn_ti clustering of voltage-dependent potassium channels|voltage-gated potassium channel clustering|Kv channel clustering|clustering of voltage gated potassium channels biological_process owl:Class
GO:0045161 biolink:NamedThing neuronal ion channel clustering The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. got7fsn_ti biological_process owl:Class
GO:0031162 biolink:NamedThing sulfur incorporation into metallo-sulfur cluster The incorporation of exogenous sulfur into a metallo-sulfur cluster. got7fsn_ti sulphur incorporation into metallo-sulphur cluster biological_process owl:Class
GO:0033541 biolink:NamedThing fatty acid beta-oxidation, unsaturated, odd number A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti MetaCyc:PWY-5137 biological_process owl:Class
GO:0070763 biolink:NamedThing Delta1 complex A protein complex that consists of homodimer of the Notch ligand Delta1. got7fsn_ti Delta1 homodimer complex mah 2009-06-29T01:04:12Z cellular_component owl:Class
GO:0047839 biolink:NamedThing dATP(dGTP)-DNA purinetransferase activity Catalysis of the reaction: dATP + depurinated DNA = ribose triphosphate + DNA. got7fsn_ti dATP(dGTP)--DNA purine transferase activity|dATP(dGTP):depurinated-DNA purine transferase activity MetaCyc:DATPDGTP--DNA-PURINE-TRANSFERASE-RXN|EC:2.6.99.1 molecular_function owl:Class
GO:0071726 biolink:NamedThing cellular response to diacyl bacterial lipopeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus. got7fsn_ti cellular response to diacylated bacterial lipoprotein Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. mah 2010-03-17T02:17:02Z biological_process owl:Class
GO:0052741 biolink:NamedThing (R)-limonene 6-monooxygenase activity Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+. got7fsn_ti (+)-limonene 6-monooxygenase activity|(+)-limonene-6-hydroxylase activity|(R)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity EC:1.14.14.53|RHEA:18957|MetaCyc:1.14.13.84-RXN|KEGG_REACTION:R06119 molecular_function owl:Class
GO:0019113 biolink:NamedThing limonene monooxygenase activity Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene. got7fsn_ti EC:1.14.13.- molecular_function owl:Class
GO:0019966 biolink:NamedThing interleukin-1 binding Binding to interleukin-1. got7fsn_ti IL-1 binding molecular_function owl:Class
GO:1990516 biolink:NamedThing ribonucleotide excision repair The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase. got7fsn_ti al 2014-10-14T12:24:37Z biological_process owl:Class
GO:0070716 biolink:NamedThing mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication A mismatch repair process that corrects errors introduced that ensures the accuracy of DNA replication. got7fsn_ti mismatch repair involved in maintenance of fidelity during DNA-dependent DNA replication mah 2009-06-09T04:00:29Z biological_process owl:Class
GO:0046232 biolink:NamedThing carbazole catabolic process The chemical reactions and pathways resulting in the breakdown of carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen. got7fsn_ti carbazole breakdown|carbazole catabolism|carbazole degradation biological_process owl:Class
GO:0040027 biolink:NamedThing negative regulation of vulval development Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. got7fsn_ti downregulation of vulval development|down-regulation of vulval development|down regulation of vulval development|inhibition of vulval development biological_process owl:Class
GO:0061064 biolink:NamedThing negative regulation of nematode larval development Any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. got7fsn_ti dph 2010-03-11T01:04:39Z biological_process owl:Class
GO:0010225 biolink:NamedThing response to UV-C Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. got7fsn_ti response to UVC radiation stimulus|response to shortwave ultraviolet radiation stimulus|response to UV-C light stimulus|response to UV-C radiation stimulus|response to UVC light stimulus|response to germicidal ultraviolet radiation stimulus|response to shortwave ultraviolet light stimulus|response to germicidal ultraviolet light stimulus biological_process owl:Class
GO:0030950 biolink:NamedThing establishment or maintenance of actin cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures. got7fsn_ti biological_process owl:Class
GO:0009907 biolink:NamedThing response to photoperiod, red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. got7fsn_ti biological_process owl:Class
GO:0009648 biolink:NamedThing photoperiodism Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species. got7fsn_ti response to night length|response to day length|response to photoperiod Wikipedia:Photoperiodism biological_process owl:Class
GO:1901080 biolink:NamedThing regulation of relaxation of smooth muscle Any process that modulates the frequency, rate or extent of relaxation of smooth muscle. got7fsn_ti regulation of smooth muscle relaxation jl 2012-07-04T10:45:09Z biological_process owl:Class
GO:0102682 biolink:NamedThing N6-(Delta2-isopentenyl)-adenosine 5'-monophosphate phosphoribohydrolase activity Catalysis of the reaction: N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O <=> N(6)-dimethylallyladenine + D-ribofuranose 5-phosphate. got7fsn_ti MetaCyc:RXN-4313|RHEA:48560 molecular_function owl:Class
GO:0120196 biolink:NamedThing negative regulation of anther dehiscence Any process that stops, prevents, or reduces the frequency, rate or extent of anther dehiscence. got7fsn_ti krc 2019-04-09T22:03:16Z biological_process owl:Class
GO:2000241 biolink:NamedThing regulation of reproductive process Any process that modulates the frequency, rate or extent of reproductive process. got7fsn_ti mah 2010-11-10T02:44:02Z biological_process owl:Class
GO:0072326 biolink:NamedThing vulval cell fate determination The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell regardless of its environment; upon determination, the cell fate cannot be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. got7fsn_ti mah 2010-11-01T02:04:46Z biological_process owl:Class
GO:0003039 biolink:NamedThing detection of reduced oxygen by carotid body chemoreceptor signaling The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body. got7fsn_ti detection of reduced oxygen by carotid body chemoreceptor signalling biological_process owl:Class
GO:0003020 biolink:NamedThing detection of reduced oxygen by chemoreceptor signaling The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. got7fsn_ti detection of reduced oxygen by chemoreceptor signalling biological_process owl:Class
GO:0005362 biolink:NamedThing low-affinity glucose:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low-affinity glucose-sodium cotransporter activity Reactome:R-HSA-429567 molecular_function owl:Class
GO:0005412 biolink:NamedThing glucose:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). got7fsn_ti sodium/glucose symporter activity Reactome:R-HSA-8932955|Reactome:R-HSA-5656356|Reactome:R-HSA-429613|Reactome:R-HSA-5658163|Reactome:R-HSA-189208 molecular_function owl:Class
GO:0007212 biolink:NamedThing dopamine receptor signaling pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands. got7fsn_ti dopamine receptor signalling pathway biological_process owl:Class
GO:0048353 biolink:NamedThing primary endosperm nucleus Nucleus resulting from the fusion of the male gamete and two polar nuclei in the central cell of the embryo sac. got7fsn_ti cellular_component owl:Class
GO:0102377 biolink:NamedThing steviol 13-O glucosyltransferase activity Catalysis of the reaction: steviol + UDP-alpha-D-glucose = steviolmonoside + UDP + H+. got7fsn_ti MetaCyc:RXN-13511 molecular_function owl:Class
GO:0000321 biolink:NamedThing re-entry into mitotic cell cycle after pheromone arrest The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti biological_process owl:Class
GO:0000320 biolink:NamedThing re-entry into mitotic cell cycle The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state. got7fsn_ti biological_process owl:Class
GO:0044172 biolink:NamedThing host cell endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport. got7fsn_ti host ER-Golgi intermediate compartment|host cell ER-Golgi intermediate compartment jl 2009-09-04T02:44:07Z cellular_component owl:Class
GO:0043138 biolink:NamedThing 3'-5' DNA helicase activity Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. got7fsn_ti ATP-dependent 3'-5' DNA helicase activity|ATP-dependent 3' to 5' DNA helicase activity|3' to 5' DNA helicase activity GO:0043140 Reactome:R-HSA-9684118|Reactome:R-HSA-167097|Reactome:R-HSA-9613497|Reactome:R-HSA-9613498|Reactome:R-HSA-75949|Reactome:R-HSA-174438|Reactome:R-HSA-9613494|Reactome:R-HSA-9613490 molecular_function owl:Class
GO:0003678 biolink:NamedThing DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis. got7fsn_ti ATP-dependent DNA helicase activity GO:0003679|GO:0004003 Reactome:R-HSA-5693589|EC:3.6.4.12 molecular_function owl:Class
GO:0010145 biolink:NamedThing fructan metabolic process The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues. got7fsn_ti levan metabolic process|fructan metabolism biological_process owl:Class
GO:0044761 biolink:NamedThing negative regulation by symbiont of host cholinergic synaptic transmission Any process in which a symbiont organism negatively regulates cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism. got7fsn_ti jl 2012-12-06T15:43:53Z biological_process owl:Class
GO:0032223 biolink:NamedThing negative regulation of synaptic transmission, cholinergic Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. got7fsn_ti downregulation of synaptic transmission, cholinergic|inhibition of synaptic transmission, cholinergic|down regulation of synaptic transmission, cholinergic|down-regulation of synaptic transmission, cholinergic biological_process owl:Class
GO:0061104 biolink:NamedThing adrenal chromaffin cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an adrenal chromaffin cell. An adrenal chromaffin cell is a neuroendocrine cell that stores epinephrine secretory vesicles. got7fsn_ti dph 2010-04-29T08:27:53Z biological_process owl:Class
GO:0010488 biolink:NamedThing UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP. got7fsn_ti molecular_function owl:Class
GO:0048804 biolink:NamedThing imaginal disc-derived female genitalia morphogenesis The process in which the anatomical structures of female genitalia are generated and organized from the genital disc. got7fsn_ti female genital morphogenesis biological_process owl:Class
GO:0048807 biolink:NamedThing female genitalia morphogenesis The process in which the anatomical structures of female genitalia are generated and organized. got7fsn_ti female genital morphogenesis biological_process owl:Class
GO:0018878 biolink:NamedThing aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen. got7fsn_ti aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism biological_process owl:Class
GO:0018877 biolink:NamedThing beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health. got7fsn_ti beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism UM-BBD_pathwayID:hch biological_process owl:Class
GO:0031366 biolink:NamedThing N-terminal peptidyl-asparagine deamination The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein. got7fsn_ti biological_process owl:Class
GO:0031364 biolink:NamedThing N-terminal protein amino acid deamination, from side chain The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein. got7fsn_ti biological_process owl:Class
GO:0098571 biolink:NamedThing lumenal side of plastid thylakoid membrane The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface. got7fsn_ti cellular_component owl:Class
GO:0071228 biolink:NamedThing cellular response to tumor cell Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell. got7fsn_ti mah 2009-12-03T02:04:43Z biological_process owl:Class
GO:0106176 biolink:NamedThing clathrin-coated endocytic vesicle lumen The volume enclosed by the membrane of a clathrin-coated endocytic vesicle. got7fsn_ti hjd 2019-02-12T15:44:51Z cellular_component owl:Class
GO:0071682 biolink:NamedThing endocytic vesicle lumen The volume enclosed by the membrane of an endocytic vesicle. got7fsn_ti mah 2010-02-18T04:21:53Z cellular_component owl:Class
GO:0015948 biolink:NamedThing methanogenesis The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. got7fsn_ti methane biosynthesis|methane biosynthetic process Wikipedia:Methanogenesis|UM-BBD_pathwayID:meth biological_process owl:Class
GO:0034417 biolink:NamedThing bisphosphoglycerate 3-phosphatase activity Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 2-phospho-D-glycerate + phosphate. got7fsn_ti 2,3-bisphospho-D-glycerate 3-phosphohydrolase activity MetaCyc:RXN-11102|RHEA:27381|KEGG_REACTION:R09532|EC:3.1.3.80 molecular_function owl:Class
GO:0034416 biolink:NamedThing bisphosphoglycerate phosphatase activity Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate. got7fsn_ti 2,3-diphosphoglycerate phosphatase activity|diphosphoglycerate phosphatase activity|glycerate-2,3-diphosphate phosphatase activity|2,3-bisphosphoglycerate phosphatase activity|2,3-diphosphoglyceric acid phosphatase activity molecular_function owl:Class
GO:0102882 biolink:NamedThing beta-acoradiene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-acoradiene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8423 molecular_function owl:Class
GO:0032972 biolink:NamedThing regulation of muscle filament sliding speed Any process that modulates the velocity of muscle filament sliding. got7fsn_ti biological_process owl:Class
GO:0032971 biolink:NamedThing regulation of muscle filament sliding Any process that modulates the frequency, rate or extent of muscle filament sliding. got7fsn_ti biological_process owl:Class
GO:0102697 biolink:NamedThing trans-zeatin-O-glucoside UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + O-beta-D-glucosyl-trans-zeatin = H+ + trans-zeatin-O-glucoside-7-N-glucoside + UDP. got7fsn_ti MetaCyc:RXN-4736 molecular_function owl:Class
GO:0005640 biolink:NamedThing nuclear outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. got7fsn_ti nucleus outer envelope|perinuclear membrane NIF_Subcellular:sao1617136075 cellular_component owl:Class
GO:0031965 biolink:NamedThing nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. got7fsn_ti NIF_Subcellular:sao1687101204 cellular_component owl:Class
GO:0098754 biolink:NamedThing detoxification Any process that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. got7fsn_ti biological_process owl:Class
GO:0006429 biolink:NamedThing leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0009541 biolink:NamedThing etioplast prolamellar body A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast. got7fsn_ti cellular_component owl:Class
GO:0035621 biolink:NamedThing ER to Golgi ceramide transport The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid. got7fsn_ti non-vesicular ceramide trafficking|ER to Golgi ceramide translocation|endoplasmic reticulum to Golgi ceramide transport bf 2010-12-08T12:36:35Z biological_process owl:Class
GO:0032365 biolink:NamedThing intracellular lipid transport The directed movement of lipids within cells. got7fsn_ti biological_process owl:Class
GO:0003101 biolink:NamedThing regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system. got7fsn_ti regulation of blood pressure by circulating adrenaline-noradrenaline biological_process owl:Class
GO:0046064 biolink:NamedThing dCMP biosynthetic process The chemical reactions and pathways resulting in the formation of dCMP, deoxycytidine monophosphate. got7fsn_ti dCMP anabolism|dCMP biosynthesis|dCMP synthesis|dCMP formation biological_process owl:Class
GO:0042042 biolink:NamedThing tungsten incorporation into tungsten-molybdopterin complex The incorporation of tungsten into a tungsten-molybdopterin complex. got7fsn_ti biological_process owl:Class
GO:0042040 biolink:NamedThing metal incorporation into metallo-molybdopterin complex The incorporation of a metal into a metallo-molybdopterin complex. got7fsn_ti biological_process owl:Class
GO:0047807 biolink:NamedThing cytokinin 7-beta-glucosyltransferase activity Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-7-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event. got7fsn_ti cytokinin 7-glucosyltransferase activity|uridine diphosphoglucose-zeatin 7-glucosyltransferase activity|cytokinin 7-b-glucosyltransferase activity|UDP-glucose:zeatin 7-glucosyltransferase activity|UDP-glucose-zeatin 7-glucosyltransferase activity|UDPglucose:zeatin 7-glucosyltransferase activity EC:2.4.1.118|KEGG_REACTION:R04071|RHEA:23272|MetaCyc:CYTOKININ-7-BETA-GLUCOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0018766 biolink:NamedThing dihydrophloroglucinol hydrolase activity Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate. got7fsn_ti UM-BBD_reactionID:r0008|MetaCyc:R6-RXN|KEGG_REACTION:R07831 molecular_function owl:Class
GO:0034815 biolink:NamedThing cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+. got7fsn_ti EC:4.1.3.-|UM-BBD_reactionID:r1135 molecular_function owl:Class
GO:0019185 biolink:NamedThing snRNA-activating protein complex A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters. got7fsn_ti SNAPc cellular_component owl:Class
GO:0051738 biolink:NamedThing xanthophyll binding Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen. got7fsn_ti molecular_function owl:Class
GO:0021771 biolink:NamedThing lateral geniculate nucleus development The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina. got7fsn_ti LGN development biological_process owl:Class
GO:0031729 biolink:NamedThing CCR4 chemokine receptor binding Binding to a CCR4 chemokine receptor. got7fsn_ti CCR4 chemokine receptor ligand molecular_function owl:Class
GO:0071752 biolink:NamedThing secretory dimeric IgA immunoglobulin complex A dimeric form of secretory IgA immunoglobulin complex. got7fsn_ti secretory dimeric IgA antibody|secretory dimeric IgA1 antibody Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0071751 biolink:NamedThing secretory IgA immunoglobulin complex A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component. got7fsn_ti sIgA antibody|secretory IgA antibody|sIgA1 antibody Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. In human only the IgA1 isotype in the polymeric form is capable of becoming secretory IgA. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0047014 biolink:NamedThing glycerol-3-phosphate 1-dehydrogenase [NADP+] activity Catalysis of the reaction: sn-glycerol 3-phosphate + NADP(+) = D-glyceraldehyde 3-phosphate + H(+) + NADPH. got7fsn_ti NADPH-dependent glycerin-3-phosphate dehydrogenase activity|glycerin-3-phosphate dehydrogenase activity|L-glycerol 3-phosphate:NADP oxidoreductase activity|sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase activity|glycerol phosphate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity MetaCyc:1.1.1.177-RXN|KEGG_REACTION:R00845|EC:1.1.1.177|RHEA:19773 molecular_function owl:Class
GO:0045002 biolink:NamedThing double-strand break repair via single-strand annealing Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats. got7fsn_ti biological_process owl:Class
GO:0102974 biolink:NamedThing hydroxyversicolorone reductase activity Catalysis of the reaction: versicolorone + NADP = hydroxyversicolorone + NADPH. got7fsn_ti MetaCyc:RXN-9489|RHEA:35691|EC:1.1.1.353 molecular_function owl:Class
GO:0010138 biolink:NamedThing pyrimidine ribonucleotide salvage The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis. got7fsn_ti MetaCyc:PWY0-163 biological_process owl:Class
GO:0071983 biolink:NamedThing exit from reproductive diapause The dormancy process that results in exit from reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. got7fsn_ti mah 2010-10-21T04:48:12Z biological_process owl:Class
GO:0071981 biolink:NamedThing exit from diapause The dormancy process that results in exit from diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. got7fsn_ti mah 2010-10-21T04:45:40Z biological_process owl:Class
GO:1990660 biolink:NamedThing calprotectin complex A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. got7fsn_ti calprotectin heterodimer An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). bhm 2015-02-25T14:03:17Z cellular_component owl:Class
GO:0048456 biolink:NamedThing stamen structural organization The process that contributes to the act of creating the structural organization of the stamen. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti stamen structural organisation GO:0048428 biological_process owl:Class
GO:0045008 biolink:NamedThing depyrimidination The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar. got7fsn_ti biological_process owl:Class
GO:0006285 biolink:NamedThing base-excision repair, AP site formation The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired. got7fsn_ti biological_process owl:Class
GO:0052603 biolink:NamedThing 1-chloro-4-nitrosobenzene nitroreductase activity Catalysis of the reaction: 1-chloro-4-nitrosobenzene + NADPH + H+ = 1-chloro-4-hydroxylaminobenzene + NADP+ + H2O. got7fsn_ti UM-BBD_enzymeID:e0245|MetaCyc:RXN-8834 molecular_function owl:Class
GO:0060432 biolink:NamedThing lung pattern specification process Any developmental process that results in the creation of defined areas or spaces within the lung, to which cells respond and eventually are instructed to differentiate. got7fsn_ti biological_process owl:Class
GO:0016049 biolink:NamedThing cell growth The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. got7fsn_ti non-developmental growth of a unicellular organism|metabolic process resulting in cell growth|cellular growth|non-developmental cell growth|metabolism resulting in cell growth|cell expansion|growth of cell GO:0048591 biological_process owl:Class
GO:0009828 biolink:NamedThing plant-type cell wall loosening The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana. got7fsn_ti cellulose and pectin-containing cell wall loosening biological_process owl:Class
GO:0009827 biolink:NamedThing plant-type cell wall modification The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana. got7fsn_ti cellulose and pectin-containing cell wall modification biological_process owl:Class
GO:0008502 biolink:NamedThing melatonin receptor activity Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin. got7fsn_ti molecular_function owl:Class
GO:0036132 biolink:NamedThing 13-prostaglandin reductase activity Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin. got7fsn_ti prostaglandin delta13-reductase activity|15-oxo-delta13-prostaglandin reductase activity|15-ketoprostaglandin delta13-reductase activity|delta13-15-ketoprostaglandin reductase activity|prostaglandin 13-reductase activity|15-oxoprostaglandin 13-reductase activity Note that this is the reverse of the reaction described in '15-oxoprostaglandin 13-oxidase activity ; GO:0047522'. bf 2012-03-05T10:42:22Z EC:1.3.1.48|KEGG_REACTION:R04556|Reactome:R-HSA-2161692|KEGG_REACTION:R04557 molecular_function owl:Class
GO:0001806 biolink:NamedThing type IV hypersensitivity An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation. got7fsn_ti delayed hypersensitivity response|delayed-type hypersensitivity GO:0016069 Wikipedia:Type_IV_hypersensitivity biological_process owl:Class
GO:0001163 biolink:NamedThing RNA polymerase I transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I. got7fsn_ti RNA polymerase I regulatory region DNA binding https://github.com/geneontology/go-ontology/issues/19312 krc 2011-01-31T04:12:06Z GO:0001013 molecular_function owl:Class
GO:0034713 biolink:NamedThing type I transforming growth factor beta receptor binding Binding to a type I transforming growth factor beta receptor. got7fsn_ti babo binding|transforming growth factor beta receptor type I binding|sax binding|tkv binding|saxophone ligand|transforming growth factor beta ligand binding to type I receptor|sax ligand|babo ligand|thickveins binding|tkv ligand|TGF-beta type I binding|thickveins ligand|type I TGF-beta binding|baboon binding|saxophone binding|baboon receptor ligand|baboon ligand GO:0005103|GO:0005116|GO:0005120 molecular_function owl:Class
GO:0102508 biolink:NamedThing cyanidin 3,7-diglucoside glucosidase activity Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + H2O <=> cyanidin 3-O-beta-D-glucoside betaine + beta-D-glucose. got7fsn_ti MetaCyc:RXN-14435 molecular_function owl:Class
GO:0046925 biolink:NamedThing peptide cross-linking via 2-(S-L-cysteinyl)-D-phenylalanine The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-D-phenylalanine. got7fsn_ti RESID:AA0341 biological_process owl:Class
GO:0022017 biolink:NamedThing neuroblast division in pallium The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons. got7fsn_ti biological_process owl:Class
GO:0021873 biolink:NamedThing forebrain neuroblast division The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast. got7fsn_ti biological_process owl:Class
GO:0035270 biolink:NamedThing endocrine system development Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes. got7fsn_ti biological_process owl:Class
GO:0062154 biolink:NamedThing N6-mAMP deaminase activity Catalysis of the reaction: H(+) + H2O + N6-methyl-AMP = IMP + methylamine. got7fsn_ti MAPDA dph 2019-09-20T13:16:37Z RHEA:16001 molecular_function owl:Class
GO:0034054 biolink:NamedThing suppression by symbiont of host defense-related programmed cell death Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti inhibition of hypersensitive response|negative regulation by symbiont of plant HR|negative regulation by symbiont of plant hypersensitive response|negative regulation by symbiont of host defense-related programmed cell death|down-regulation by symbiont of host defense-related programmed cell death|down regulation by symbiont of host defense-related programmed cell death|inhibition of HR|negative regulation by symbiont of host defense-related PCD|inhibition by symbiont of host defense-related PCD|inhibition by symbiont of host defense-related programmed cell death|downregulation by symbiont of host defense-related programmed cell death|inhibition of host defense-related PCD|suppression by symbiont of host defense-related programmed cell death|suppression of HR Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of plant-type hypersensitive response ; GO:0034051'. biological_process owl:Class
GO:0052041 biolink:NamedThing negative regulation by symbiont of host programmed cell death Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti inhibition of host programmed cell death|down-regulation by symbiont of host programmed cell death|inhibition by symbiont of host programmed cell death|suppression by symbiont of host programmed cell death|down regulation by symbiont of host programmed cell death|suppression by symbiont of host PCD|downregulation by symbiont of host programmed cell death biological_process owl:Class
GO:0048912 biolink:NamedThing glial cell migration in anterior lateral line nerve The movement of a glial cell along the axons in the anterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0048896 biolink:NamedThing lateral line nerve glial cell migration The movement of a glial cell along the axons in a lateral line nerve. got7fsn_ti glial cell migration in lateral line nerve biological_process owl:Class
GO:0000992 biolink:NamedThing RNA polymerase III cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes. got7fsn_ti krc 2010-08-11T03:49:28Z molecular_function owl:Class
GO:0047646 biolink:NamedThing alkanal monooxygenase (FMN-linked) activity Catalysis of the reaction: R-CHO + reduced FMN + O2 = R-COOH + FMN + H2O + light. got7fsn_ti aldehyde monooxygenase activity|bacterial luciferase activity|vibrio fischeri luciferase activity|alkanal,reduced-FMN:oxygen oxidoreductase (1-hydroxylating, luminescing) RHEA:17181|EC:1.14.14.3|MetaCyc:ALKANAL-MONOOXYGENASE-FMN-LINKED-RXN molecular_function owl:Class
GO:0140303 biolink:NamedThing intramembrane lipid transporter activity Enables the transport of a lipid from a region of a membrane to a different region on the same membrane. got7fsn_ti flippase activity|translocase activity https://github.com/geneontology/go-ontology/issues/19477|https://github.com/geneontology/go-ontology/issues/17648 pg 2019-03-01T20:14:09Z molecular_function owl:Class
GO:0005319 biolink:NamedThing lipid transporter activity Enables the directed movement of lipids into, out of or within a cell, or between cells. got7fsn_ti apolipoprotein|lipophorin Reactome:R-HSA-5688397|Reactome:R-HSA-8848053|Reactome:R-HSA-5683672|Reactome:R-HSA-174786|Reactome:R-HSA-1369028|Reactome:R-HSA-8866329|Reactome:R-HSA-5682285|Reactome:R-HSA-5682311|Reactome:R-HSA-5683714|Reactome:R-HSA-6801250|Reactome:R-HSA-1369052 molecular_function owl:Class
GO:0099637 biolink:NamedThing neurotransmitter receptor transport The directed movement of neurotransmitter receptors. got7fsn_ti biological_process owl:Class
GO:0045578 biolink:NamedThing negative regulation of B cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation. got7fsn_ti down-regulation of B cell differentiation|down regulation of B cell differentiation|negative regulation of B cell development|inhibition of B cell differentiation|negative regulation of B lymphocyte differentiation|downregulation of B cell differentiation|negative regulation of B-cell differentiation|negative regulation of B-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0045620 biolink:NamedThing negative regulation of lymphocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation. got7fsn_ti negative regulation of lymphocyte development|inhibition of lymphocyte differentiation|down regulation of lymphocyte differentiation|downregulation of lymphocyte differentiation|down-regulation of lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0036011 biolink:NamedThing imaginal disc-derived leg segmentation Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint. got7fsn_ti bf 2011-10-07T04:37:17Z biological_process owl:Class
GO:0035285 biolink:NamedThing appendage segmentation Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented. got7fsn_ti biological_process owl:Class
GO:0021660 biolink:NamedThing rhombomere 3 formation The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0021594 biolink:NamedThing rhombomere formation The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. got7fsn_ti biological_process owl:Class
GO:0021655 biolink:NamedThing rhombomere 2 morphogenesis The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0042023 biolink:NamedThing DNA endoreduplication Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes. got7fsn_ti DNA endoreplication|DNA re-duplication Note that this term is only to be used in situations were this process occurs normally. Not to be used to describe mutant or diseased states. biological_process owl:Class
GO:0009448 biolink:NamedThing gamma-aminobutyric acid metabolic process The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. got7fsn_ti gamma-aminobutyric acid metabolism|4-aminobutyrate metabolism|4-aminobutanoate metabolism|4-aminobutyrate metabolic process|4-aminobutanoate metabolic process|GABA metabolism|GABA metabolic process See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. biological_process owl:Class
GO:0030117 biolink:NamedThing membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. got7fsn_ti cellular_component owl:Class
GO:0060603 biolink:NamedThing mammary gland duct morphogenesis The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk. got7fsn_ti dph 2009-05-15T09:22:25Z biological_process owl:Class
GO:0001991 biolink:NamedThing regulation of systemic arterial blood pressure by circulatory renin-angiotensin The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen. got7fsn_ti control of blood pressure by circulatory renin-angiotensin|renin-angiotensin blood pressure control|circulatory renin-angiotensin regulation of blood pressure|circulatory renin-angiotensin blood pressure regulation|circulatory renin-angiotensin control of blood pressure biological_process owl:Class
GO:0046937 biolink:NamedThing phytochelatin metabolic process The chemical reactions and pathways involving phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. got7fsn_ti phytochelatin metabolism|cadystin metabolism|cadystin metabolic process biological_process owl:Class
GO:0002385 biolink:NamedThing mucosal immune response An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. got7fsn_ti immune response in mucosal-associated lymphoid tissue|immune response in MALT|immune response in urogenital tract GO:0002422|GO:0002386 biological_process owl:Class
GO:0030773 biolink:NamedThing 6-hydroxymellein O-methyltransferase activity Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+). got7fsn_ti 6-hydroxymellein methyltransferase activity|S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN|KEGG_REACTION:R03934|RHEA:15201|EC:2.1.1.108 molecular_function owl:Class
GO:0042932 biolink:NamedThing chrysobactin transport The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0070612 biolink:NamedThing histone methyltransferase activity (H2A-R3 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H2A)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H2A)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H2A. got7fsn_ti histone-arginine N-methyltransferase activity (H2A-R3 specific)|histone methylase activity (H2A-R3 specific) mah 2009-04-29T02:06:45Z molecular_function owl:Class
GO:0047520 biolink:NamedThing 11-cis-retinyl-palmitate hydrolase activity Catalysis of the reaction: 11-cis-retinyl palmitate + H(2)O = 11-cis-retinol + H(+) + palmitate. got7fsn_ti RPH|11-cis-retinol palmitate esterase activity|11-cis-retinyl-palmitate acylhydrolase activity KEGG_REACTION:R03049|RHEA:19697|MetaCyc:11-CIS-RETINYL-PALMITATE-HYDROLASE-RXN|Reactome:R-HSA-2465941|EC:3.1.1.63 molecular_function owl:Class
GO:0043853 biolink:NamedThing methanol-CoM methyltransferase complex A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol. got7fsn_ti methanol: CoM methyltransferase complex|methanol-coenzyme M methyltransferase complex|methanol:coenzyme M methyltransferase complex|methanol: coenzyme M methyltransferase complex|methanol:CoM methyltransferase complex MetaCyc:CPLX-421 cellular_component owl:Class
GO:0031753 biolink:NamedThing endothelial differentiation G protein-coupled receptor binding Binding to an endothelial differentiation G protein-coupled receptor. got7fsn_ti endothelial differentiation G-protein coupled receptor binding|endothelial differentiation G-protein coupled receptor ligand molecular_function owl:Class
GO:0005267 biolink:NamedThing potassium channel activity Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti Reactome:R-HSA-1299304|Reactome:R-HSA-1296039|Reactome:R-HSA-1299359|Reactome:R-HSA-1296037|Reactome:R-HSA-1299297|Reactome:R-HSA-1296348|Reactome:R-HSA-1299338|Reactome:R-HSA-1299318|Reactome:R-HSA-1296035|Reactome:R-HSA-2534365|Reactome:R-HSA-5578910|Reactome:R-HSA-1296024 molecular_function owl:Class
GO:0102551 biolink:NamedThing homogentisate geranylgeranyl transferase activity Catalysis of the reaction: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + homogentisate + H+ <=> diphosphoric acid + 2-methyl-6-geranylgeranyl-1,4-benzoquinol + carbon dioxide. got7fsn_ti RHEA:38003|EC:2.5.1.116|MetaCyc:RXN-14929 molecular_function owl:Class
GO:0070045 biolink:NamedThing synaptobrevin 2-SNAP-25-syntaxin-2 complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 2 (or orthologs thereof). got7fsn_ti Stx2-Snap25-Vamp2 complex|SNARE complex (Stx2, Snap25, Vamp2) cellular_component owl:Class
GO:0019879 biolink:NamedThing peptidyl-thyronine biosynthetic process from peptidyl-tyrosine The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine. got7fsn_ti peptidyl-thyronine synthesis from peptidyl-tyrosine|peptidyl-thyronine anabolism from peptidyl-tyrosine|peptidyl-thyronine formation from peptidyl-tyrosine See also the biological process term 'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine ; GO:0018250'. biological_process owl:Class
GO:0022031 biolink:NamedThing telencephalon astrocyte cell migration The orderly movement of an astrocyte cell through the telencephalon. got7fsn_ti biological_process owl:Class
GO:0043615 biolink:NamedThing astrocyte cell migration The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord. got7fsn_ti astrocytic glial cell migration|astrocyte migration biological_process owl:Class
GO:0102656 biolink:NamedThing 1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-1727 molecular_function owl:Class
GO:0060228 biolink:NamedThing phosphatidylcholine-sterol O-acyltransferase activator activity Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. got7fsn_ti LCAT activator activity molecular_function owl:Class
GO:0086022 biolink:NamedThing SA node cell-atrial cardiac muscle cell adhesion involved in cell communication The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate. got7fsn_ti SA cardiac muscle cell-atrial cardiac muscle cell adhesion involved in cell communication|SA cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication|sinus node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication|sinoatrial node cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication|SAN cardiomyocyte-atrial cardiomyocyte adhesion involved in cell communication tb 2011-11-10T09:26:52Z biological_process owl:Class
GO:0004319 biolink:NamedThing enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+. got7fsn_ti enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)|enoyl acyl-carrier-protein reductase activity|enoyl-acyl-carrier-protein reductase (NADPH, B-specific)|acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)|enoyl-ACP reductase (NADPH, B-specific) activity|reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)|enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity|NADPH 2-enoyl Co A reductase activity EC:1.3.1.10|MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN molecular_function owl:Class
GO:0031931 biolink:NamedThing TORC1 complex A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p. got7fsn_ti TORC1|mTORC1|dTORC1|rapamycin and nutrient-sensitive TOR complex|dTOR/dRaptor complex|TORC 1 complex|nutrient sensitive complex|TOR complex 1 Wikipedia:MTORC1 cellular_component owl:Class
GO:0033887 biolink:NamedThing chondro-4-sulfatase activity Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 4-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate. got7fsn_ti 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity RHEA:11444|KEGG_REACTION:R03517|EC:3.1.6.9|MetaCyc:CHONDRO-4-SULFATASE-RXN molecular_function owl:Class
GO:0120159 biolink:NamedThing rRNA pseudouridine synthase activity Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. got7fsn_ti 16S rRNA pseudouridine(516) synthase|21S rRNA pseudouridine(2819) synthase|23S rRNA pseudouridine(955/2504/2580) synthase|23S rRNA pseudouridine(2604) synthase|23S rRNA pseudouridine(2457) synthase|23S rRNA pseudouridine(1911/1915/1917) synthase|23S rRNA pseudouridine(746) synthase|23S rRNA pseudouridine(2605) synthase krc 2018-05-11T21:24:19Z EC:5.4.99.24|EC:5.4.99.23|EC:5.4.99.20|EC:5.4.99.19|EC:5.4.99.21|EC:5.4.99.22|EC:5.4.99.29|EC:5.4.99.43 molecular_function owl:Class
GO:0018593 biolink:NamedThing 4-chlorophenoxyacetate monooxygenase activity Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol. got7fsn_ti UM-BBD_reactionID:r0281 molecular_function owl:Class
GO:0099401 biolink:NamedThing caveola bulb The region of a caveola that extends into the cytoplasm, excluding the neck (rim). This region is associated with intracellular caveola proteins. got7fsn_ti caveola crater cellular_component owl:Class
GO:0033947 biolink:NamedThing mannosylglycoprotein endo-beta-mannosidase activity Catalysis of the hydrolysis of the alpha-D-mannosyl-(1->6)-beta-D-mannosyl-(1->4)-beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequence of glycoprotein to alpha-D-mannosyl-(1->6)-D-mannose and beta-D-N-acetylglucosaminyl-(1->4)-beta-D-N-acetylglucosaminyl sequences. got7fsn_ti endo-beta-mannosidase activity MetaCyc:3.2.1.152-RXN|EC:3.2.1.152 molecular_function owl:Class
GO:0039010 biolink:NamedThing specification of pronephric distal tubule identity The process in which the distal tubule of the pronephric nephron acquires its identity. got7fsn_ti bf 2010-07-02T09:51:28Z biological_process owl:Class
GO:1990420 biolink:NamedThing establishment of septation initiation network asymmetry The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies. got7fsn_ti establishment of SIN asymmetry al 2014-07-16T13:51:36Z biological_process owl:Class
GO:0031028 biolink:NamedThing septation initiation signaling The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis. got7fsn_ti septation initiation signalling|SIN|septation initiation signaling cascade|septation initiation network biological_process owl:Class
GO:0004873 biolink:NamedThing asialoglycoprotein receptor activity Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane. got7fsn_ti molecular_function owl:Class
GO:0090490 biolink:NamedThing L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O. got7fsn_ti tb 2012-10-16T16:27:19Z molecular_function owl:Class
GO:0030661 biolink:NamedThing chitosome membrane The lipid bilayer surrounding a chitosome. got7fsn_ti cellular_component owl:Class
GO:0004742 biolink:NamedThing dihydrolipoyllysine-residue acetyltransferase activity Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. got7fsn_ti acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity|lipoate transacetylase activity|transacetylase X activity|enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity|dihydrolipoamide S-acetyltransferase activity|lipoylacetyltransferase activity|dihydrolipoic transacetylase activity|dihydrolipoate acetyltransferase activity|lipoic acid acetyltransferase activity|lipoate acetyltransferase activity|lipoic acetyltransferase activity|thioltransacetylase A activity|lipoic transacetylase activity|acetyl-CoA:dihydrolipoamide S-acetyltransferase activity|dihydrolipoyl acetyltransferase activity|acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity EC:2.3.1.12 molecular_function owl:Class
GO:0032050 biolink:NamedThing clathrin heavy chain binding Binding to a clathrin heavy chain. got7fsn_ti molecular_function owl:Class
GO:0030276 biolink:NamedThing clathrin binding Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. got7fsn_ti molecular_function owl:Class
GO:0033212 biolink:NamedThing iron import into cell The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. got7fsn_ti iron assimilation|ferrous iron uptake|ferrous ion import|ferrous iron import mah 2009-05-01T04:19:14Z GO:0070627 biological_process owl:Class
GO:0006879 biolink:NamedThing cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell. got7fsn_ti iron homeostasis biological_process owl:Class
GO:0071485 biolink:NamedThing cellular response to absence of light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli. got7fsn_ti cellular response to darkness mah 2009-12-18T02:13:12Z biological_process owl:Class
GO:0031325 biolink:NamedThing positive regulation of cellular metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. got7fsn_ti upregulation of cellular metabolic process|stimulation of cellular metabolic process|activation of cellular metabolic process|up regulation of cellular metabolic process|positive regulation of cellular metabolism|up-regulation of cellular metabolic process biological_process owl:Class
GO:0002757 biolink:NamedThing immune response-activating signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response. got7fsn_ti biological_process owl:Class
GO:0050579 biolink:NamedThing vellosimine dehydrogenase activity Catalysis of the reaction: 10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine. got7fsn_ti 10-deoxysarpagine:NADP+ oxidoreductase activity MetaCyc:1.1.1.273-RXN|RHEA:20029|KEGG_REACTION:R05827|EC:1.1.1.273 molecular_function owl:Class
GO:0102875 biolink:NamedThing 1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-18:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8366|EC:1.14.19.35 molecular_function owl:Class
GO:0050671 biolink:NamedThing positive regulation of lymphocyte proliferation Any process that activates or increases the rate or extent of lymphocyte proliferation. got7fsn_ti up-regulation of lymphocyte proliferation|stimulation of lymphocyte proliferation|activation of lymphocyte proliferation|up regulation of lymphocyte proliferation|upregulation of lymphocyte proliferation biological_process owl:Class
GO:0032946 biolink:NamedThing positive regulation of mononuclear cell proliferation Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation. got7fsn_ti stimulation of mononuclear cell proliferation|activation of mononuclear cell proliferation|up regulation of mononuclear cell proliferation|positive regulation of peripheral blood mononuclear cell proliferation|positive regulation of PBMC proliferation|upregulation of mononuclear cell proliferation|up-regulation of mononuclear cell proliferation biological_process owl:Class
GO:0050203 biolink:NamedThing oxalate-CoA ligase activity Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA. got7fsn_ti oxalyl-CoA synthetase activity|oxalyl coenzyme A synthetase activity|oxalate:CoA ligase (AMP-forming) MetaCyc:OXALATE--COA-LIGASE-RXN|RHEA:18293|EC:6.2.1.8|KEGG_REACTION:R01558 molecular_function owl:Class
GO:0140614 biolink:NamedThing 1,8-dihydroxynaphthalene-melanin biosynthetic process The chemical reactions and pathways resulting in the formation of dihydroxy naphthalene (DHN)-melanin. got7fsn_ti DHN-melanin biosynthesis https://github.com/geneontology/go-ontology/issues/20974 pg 2021-03-04T11:54:05Z biological_process owl:Class
GO:0052828 biolink:NamedThing inositol-3,4-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate. got7fsn_ti ai 2011-11-29T09:57:00Z RHEA:43388|Reactome:R-HSA-1855202 molecular_function owl:Class
GO:0016312 biolink:NamedThing inositol bisphosphate phosphatase activity Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate. got7fsn_ti RHEA:57840|Reactome:R-HSA-6809565|Reactome:R-HSA-6809561 molecular_function owl:Class
GO:0031580 biolink:NamedThing membrane raft distribution The process that establishes the spatial arrangement of membrane rafts within a cellular membrane. got7fsn_ti lipid raft distribution biological_process owl:Class
GO:0044535 biolink:NamedThing very-long-chain fatty acyl-CoA oxidase activity Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. got7fsn_ti very-long-chain acyl-CoA oxidase activity|very long chain fatty-acyl-CoA oxidase activity|VLC fatty-acyl-CoA oxidase activity jl 2012-03-21T02:04:42Z EC:1.3.3.- molecular_function owl:Class
GO:0022619 biolink:NamedThing generative cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte. got7fsn_ti biological_process owl:Class
GO:0016160 biolink:NamedThing amylase activity Catalysis of the hydrolysis of amylose or an amylose derivative. got7fsn_ti molecular_function owl:Class
GO:0019646 biolink:NamedThing aerobic electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient. got7fsn_ti ubiquinone-8-O2 electron transport|succinate-O2 electron transport|NADH-O2 electron transport GO:0006137|GO:0006138|GO:0006136 biological_process owl:Class
GO:0018359 biolink:NamedThing protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine. got7fsn_ti protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine GO:0018385 RESID:AA0266 biological_process owl:Class
GO:0014853 biolink:NamedThing regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. got7fsn_ti regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction biological_process owl:Class
GO:0098815 biolink:NamedThing modulation of excitatory postsynaptic potential Any process that modulates the frequency, rate or extent of excitatory postsynaptic potential (EPSP). EPSP is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. got7fsn_ti biological_process owl:Class
GO:0110011 biolink:NamedThing regulation of basement membrane organization Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane. got7fsn_ti kmv biological_process owl:Class
GO:0120117 biolink:NamedThing T cell meandering migration The random-like motility observed for T cells in lymph nodes which enhances surveillance of antigens presented by major histocompatibility complex (MHC) molecules on antigen presenting cells (APCs). got7fsn_ti T cell meandering search|lymph node surveillance krc 2017-11-22T18:13:01Z biological_process owl:Class
GO:1990006 biolink:NamedThing amorphous vesicle A cytoplasmic membrane-bounded vesicle first described in dendrites, categorized by smooth membranes, electron-lucent interiors and irregular shapes. Sometimes occurs in clumps. Amorphous vesicles have been found to contain material taken up from the extracellular space, therefore suggesting that they may be part of the endosomal pathway. got7fsn_ti pr 2012-12-11T14:55:36Z NIF_Subcellular:sao1531915298 cellular_component owl:Class
GO:0010160 biolink:NamedThing formation of animal organ boundary The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. got7fsn_ti organ boundary specification GO:0048862 biological_process owl:Class
GO:0015929 biolink:NamedThing hexosaminidase activity Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. got7fsn_ti MetaCyc:3.2.1.52-RXN molecular_function owl:Class
GO:0090369 biolink:NamedThing ornithine carbamoyltransferase inhibitor activity Binds to and stops, prevents, or reduces the activity of ornithine carbamoyltransferase. got7fsn_ti tb 2010-07-12T11:19:55Z molecular_function owl:Class
GO:0022416 biolink:NamedThing chaeta development The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell. got7fsn_ti bristle development biological_process owl:Class
GO:0014730 biolink:NamedThing skeletal muscle regeneration at neuromuscular junction The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers. got7fsn_ti biological_process owl:Class
GO:0043403 biolink:NamedThing skeletal muscle tissue regeneration The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. got7fsn_ti myofiber turnover biological_process owl:Class
GO:0060886 biolink:NamedThing clearance of cells from fusion plate by epithelial to mesenchymal transition The process of epithelial to mesenchymal transition that contributes to the shaping of the semicircular canal by effectively removing epithelial cells from the fusion plate, forming the loops of the canals. got7fsn_ti dph 2009-08-13T12:34:19Z biological_process owl:Class
GO:0044491 biolink:NamedThing positive regulation of molecular function in other organism Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism. got7fsn_ti jl 2012-02-01T12:21:51Z biological_process owl:Class
GO:0050205 biolink:NamedThing oxamate carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate. got7fsn_ti oxamic transcarbamylase activity|carbamoyl-phosphate:oxamate carbamoyltransferase activity KEGG_REACTION:R02937|RHEA:22984|MetaCyc:OXAMATE-CARBAMOYLTRANSFERASE-RXN|EC:2.1.3.5 molecular_function owl:Class
GO:0090666 biolink:NamedThing scaRNA localization to Cajal body A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body. got7fsn_ti tb 2015-12-15T10:57:05Z biological_process owl:Class
GO:0090670 biolink:NamedThing RNA localization to Cajal body A process in which an RNA is transported to, or maintained in, a Cajal body. got7fsn_ti tb 2015-12-17T14:04:40Z biological_process owl:Class
GO:0043670 biolink:NamedThing foot layer The inner layer of the ectexine. got7fsn_ti nexine 1 cellular_component owl:Class
GO:0008291 biolink:NamedThing acetylcholine metabolic process The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. got7fsn_ti acetylcholine metabolism biological_process owl:Class
GO:0042133 biolink:NamedThing neurotransmitter metabolic process The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. got7fsn_ti neurotransmitter metabolism biological_process owl:Class
GO:0060048 biolink:NamedThing cardiac muscle contraction Muscle contraction of cardiac muscle tissue. got7fsn_ti heart muscle contraction biological_process owl:Class
GO:0000393 biolink:NamedThing spliceosomal conformational changes to generate catalytic conformation Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation. got7fsn_ti 3'-splice site cleavage, exon ligation biological_process owl:Class
GO:0004948 biolink:NamedThing calcitonin receptor activity Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti molecular_function owl:Class
GO:0071113 biolink:NamedThing alphaIIb-beta3 integrin-ICAM-4 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell adhesion molecule ICAM-4. got7fsn_ti ITGAIIb-ITGB3-ICAM4 complex mah 2009-11-13T02:17:59Z cellular_component owl:Class
GO:0048651 biolink:NamedThing polyphenic determination, influence by environmental factors The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental cues. got7fsn_ti biological_process owl:Class
GO:1990781 biolink:NamedThing response to immobilization stress combined with electrical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile. got7fsn_ti sl 2015-06-23T20:30:42Z biological_process owl:Class
GO:0051602 biolink:NamedThing response to electrical stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. got7fsn_ti response to electricity biological_process owl:Class
GO:0050453 biolink:NamedThing cob(II)alamin reductase activity Catalysis of the reaction: 2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH. got7fsn_ti NADH:cob(II)alamin oxidoreductase activity|vitamin B12 reduction|vitamin B12 reductase activity|NADH2:cob(II)alamin oxidoreductase activity|vitamin B(12r) reductase activity|cob(I)alamin:NAD+ oxidoreductase activity|vitamin B12r reductase activity|B(12r) reductase activity|B12r reductase activity MetaCyc:COBIIALAMIN-REDUCTASE-RXN|KEGG_REACTION:R00099|EC:1.16.1.4|Reactome:R-HSA-3149560|RHEA:17481 molecular_function owl:Class
GO:0140693 biolink:NamedThing molecular condensate scaffold activity Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21937 pg 2021-08-09T15:13:52Z molecular_function owl:Class
GO:0044814 biolink:NamedThing glycolytic fermentation via PFL pathway The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli. got7fsn_ti jl 2013-09-18T16:56:02Z biological_process owl:Class
GO:0070047 biolink:NamedThing synaptobrevin 2-SNAP-25-syntaxin-4 complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof). got7fsn_ti Stx4-Snap25-Vamp2 complex|SNARE complex (Stx4, Snap25, Vamp2) cellular_component owl:Class
GO:0032111 biolink:NamedThing activation of protein histidine kinase activity Any process that initiates the activity of an inactive protein histidine kinase. got7fsn_ti protein histidine kinase activator biological_process owl:Class
GO:0010864 biolink:NamedThing positive regulation of protein histidine kinase activity Any process that increases the frequency, rate or extent of protein histidine kinase activity. got7fsn_ti biological_process owl:Class
GO:0030919 biolink:NamedThing peptidyl-serine O-acetylation The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine. got7fsn_ti RESID:AA0364 biological_process owl:Class
GO:0140683 biolink:NamedThing histone H3-di/monomethyl-lysine-9 demethylase activity Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone H3K9me demethylase activity|histone H3K9me2 demethylase activity https://github.com/geneontology/go-ontology/issues/21089 pg 2021-07-09T06:03:06Z RHEA:60188|EC:1.14.11.65 molecular_function owl:Class
GO:0033505 biolink:NamedThing floor plate morphogenesis The process in which the anatomical structure of the floor plate is generated and organized. got7fsn_ti biological_process owl:Class
GO:0097566 biolink:NamedThing left tetrad Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the left lateral basal body pair and the left middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally). got7fsn_ti Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T16:30:43Z cellular_component owl:Class
GO:0106172 biolink:NamedThing COPI-coated vesicle lumen The volume enclosed by the membrane of a COPI-coated endocytic vesicle. got7fsn_ti hjd 2019-02-11T18:04:08Z cellular_component owl:Class
GO:0052859 biolink:NamedThing glucan endo-1,4-beta-glucosidase activity Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans. got7fsn_ti endo-(1->4)-beta-D-glucanase activity|endo-1,4-beta-glucanase activity|beta-1,4-glucan 4-glucanohydrolase activity|beta-1->4-glucan hydrolase activity|1,4-beta-D-glucan glucanohydrolase activity|beta-1,4-glucan hydrolase activity|endo-1,4-beta-D-glucanase activity|endo-beta-1,4-glucanase activity|beta-1,4-glucanase activity|endo-(1,4)-beta-D-glucanase activity ai 2011-12-06T03:48:44Z EC:3.2.1.- molecular_function owl:Class
GO:0018731 biolink:NamedThing 1-oxa-2-oxocycloheptane lactonase activity Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate. got7fsn_ti UM-BBD_reactionID:r0167 molecular_function owl:Class
GO:0018461 biolink:NamedThing fluoren-9-ol dehydrogenase activity Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+. got7fsn_ti 9-fluorenol dehydrogenase activity|fluoren-9-ol:NAD(P)+ oxidoreductase activity UM-BBD_reactionID:r0408|EC:1.1.1.256|MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0048907 biolink:NamedThing anterior lateral line ganglion development The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear. got7fsn_ti gALL development biological_process owl:Class
GO:0106153 biolink:NamedThing phosphorylated histone binding Binding to a histone in which a residue has been modified by phosphorylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. got7fsn_ti hjd 2018-09-19T17:23:06Z molecular_function owl:Class
GO:0140031 biolink:NamedThing phosphorylation-dependent protein binding Binding to a protein upon phosphorylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require phosphorylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of phosphorylation. It may be that the phosphorylation causes a conformational change that allows binding of the protein to another region; this type of phosphorylation-dependent protein binding is valid for annotation to this term. pg 2017-05-17T15:15:19Z molecular_function owl:Class
GO:0009248 biolink:NamedThing K antigen biosynthetic process The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens. got7fsn_ti K antigen biosynthesis|K antigen formation|K antigen synthesis|K antigen anabolism biological_process owl:Class
GO:0046375 biolink:NamedThing K antigen metabolic process The chemical reactions and pathways involving K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens. got7fsn_ti K antigen metabolism biological_process owl:Class
GO:0031838 biolink:NamedThing haptoglobin-hemoglobin complex A protein complex formed by the stable binding of a haptoglobin to hemoglobin. got7fsn_ti cellular_component owl:Class
GO:0071839 biolink:NamedThing apoptotic process in bone marrow cell The apoptotic process in cells in the bone marrow. got7fsn_ti programmed cell death, bone marrow cells|bone marrow cell programmed cell death by apoptosis|killing of bone marrow cells|programmed cell death of bone marrow cells by apoptosis|apoptotic process in bone marrow cell|bone marrow cell apoptosis|apoptosis in bone marrow mah 2010-09-10T12:19:18Z biological_process owl:Class
GO:0052111 biolink:NamedThing modification by symbiont of host structure The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0016586 biolink:NamedThing RSC-type complex A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. got7fsn_ti Polybromo- and BAF containing complex|PBAF complex|SWI/SNF complex B https://github.com/geneontology/go-ontology/issues/14106 mah 2009-04-29T01:07:26Z GO:0070604 cellular_component owl:Class
GO:0034423 biolink:NamedThing autophagosome lumen The volume enclosed within the autophagosome double-membrane. got7fsn_ti autophagic vacuole lumen Note that this term should be used for annotating gene products with caution: it should be used only to annotate gene products demonstrated to reside and function normally in the autophagic vacuole lumen, not for molecules that are temporarily found in the lumen prior to degradation. cellular_component owl:Class
GO:0090141 biolink:NamedThing positive regulation of mitochondrial fission Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. got7fsn_ti positive regulation of mitochondrial division tb 2009-12-08T02:20:48Z biological_process owl:Class
GO:0006940 biolink:NamedThing regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. got7fsn_ti biological_process owl:Class
GO:0046919 biolink:NamedThing pyruvyltransferase activity Catalysis of the transfer of a pyruvyl (oxopropanoyl) group from one compound to another. got7fsn_ti molecular_function owl:Class
GO:0070746 biolink:NamedThing interleukin-35 binding Binding to interleukin-35. got7fsn_ti IL-35 binding mah 2009-06-23T01:15:36Z molecular_function owl:Class
GO:1903012 biolink:NamedThing positive regulation of bone development Any process that activates or increases the frequency, rate or extent of bone development. got7fsn_ti activation of bone development|up regulation of bone development|up-regulation of bone development|upregulation of bone development mr 2014-05-13T22:42:06Z biological_process owl:Class
GO:1901137 biolink:NamedThing carbohydrate derivative biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrate derivative. got7fsn_ti carbohydrate derivative anabolism|carbohydrate derivative formation|carbohydrate derivative biosynthesis|carbohydrate derivative synthesis bf 2012-07-12T04:05:39Z biological_process owl:Class
GO:0030840 biolink:NamedThing negative regulation of intermediate filament polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization. got7fsn_ti down-regulation of intermediate filament polymerization|down regulation of intermediate filament polymerization|inhibition of intermediate filament polymerization|negative regulation of intermediate filament polymerization and/or depolymerization|downregulation of intermediate filament polymerization Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843'). biological_process owl:Class
GO:0046204 biolink:NamedThing nor-spermidine metabolic process The chemical reactions and pathways involving nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. got7fsn_ti nor-spermidine metabolism biological_process owl:Class
GO:0034814 biolink:NamedThing 7,8-dihydroxy benzo(a)pyrene dioxygenase activity Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r1138 molecular_function owl:Class
GO:0072071 biolink:NamedThing kidney interstitial fibroblast differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblast of the kidney as it progresses from its formation to the mature state. got7fsn_ti kidney interstitial cell differentiation mah 2010-01-25T04:34:31Z biological_process owl:Class
GO:0060010 biolink:NamedThing Sertoli cell fate commitment The process in which the cellular identity of Sertoli cells is acquired and determined. got7fsn_ti biological_process owl:Class
GO:0036013 biolink:NamedThing cyanelle outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope. got7fsn_ti bf 2011-10-10T01:50:56Z cellular_component owl:Class
GO:0045466 biolink:NamedThing R7 cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor. got7fsn_ti biological_process owl:Class
GO:0001751 biolink:NamedThing compound eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell. got7fsn_ti biological_process owl:Class
GO:0033062 biolink:NamedThing Rhp55-Rhp57 complex A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces). got7fsn_ti Rad55-Rad57 complex cellular_component owl:Class
GO:0016444 biolink:NamedThing somatic cell DNA recombination Recombination occurring within or between DNA molecules in somatic cells. got7fsn_ti biological_process owl:Class
GO:0046292 biolink:NamedThing formaldehyde metabolic process The chemical reactions and pathways involving formaldehyde (methanal, H2C=O), a colorless liquid or gas with a pungent odor, commonly used as a fixative or an antibacterial agent. got7fsn_ti formaldehyde metabolism|methanal metabolism|methanal metabolic process biological_process owl:Class
GO:0008795 biolink:NamedThing NAD+ synthase activity Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. got7fsn_ti NAD synthase activity|diphosphopyridine nucleotide synthetase activity|NAD(+) synthetase activity|nicotinamide adenine dinucleotide synthetase activity|NAD synthetase activity|NAD synthase (AMP-forming)|deamido-NAD+:ammonia ligase (AMP-forming)|NAD+ synthetase activity GO:0016965|GO:0008749 EC:6.3.1.5|MetaCyc:NAD-SYNTH-NH3-RXN|RHEA:21188 molecular_function owl:Class
GO:1990151 biolink:NamedThing protein localization to cell tip A process in which a protein is transported to, or maintained in, a location at the cell tip. got7fsn_ti protein localisation to cell tip mah 2013-07-31T14:56:40Z biological_process owl:Class
GO:0060571 biolink:NamedThing morphogenesis of an epithelial fold The morphogenetic process in which an epithelial sheet bends along a linear axis. got7fsn_ti epithelial folding|folding of an epithelial sheet dph 2009-04-30T09:27:17Z biological_process owl:Class
GO:0051458 biolink:NamedThing corticotropin secretion The regulated release of corticotropin by a cell. Corticotropin hormone is a polypeptide hormone synthesized and secreted from corticotropes in the anterior lobe of the pituitary gland in response to corticotropin-releasing hormone (CRH) released by the hypothalamus. got7fsn_ti adrenotropin secretion|adrenocorticotropin secretion|adrenocorticotropic hormone secretion|ACTH secretion|corticotropic hormone secretion|adrenotropic hormone secretion biological_process owl:Class
GO:0005656 biolink:NamedThing nuclear pre-replicative complex A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins. got7fsn_ti pre-replicative complex|pre-RC|eukaryotic pre-replicative complex cellular_component owl:Class
GO:0036387 biolink:NamedThing pre-replicative complex A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. got7fsn_ti pre-replication complex|pre-RC This term describes pre-replicative complexes across organisms. bf 2013-06-05T16:14:52Z cellular_component owl:Class
GO:0004658 biolink:NamedThing propionyl-CoA carboxylase activity Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA. got7fsn_ti propanoyl-CoA:carbon-dioxide ligase (ADP-forming)|propionyl coenzyme A carboxylase activity|PCCase activity Reactome:R-HSA-71031|EC:6.4.1.3|MetaCyc:PROPIONYL-COA-CARBOXY-RXN|RHEA:23720 molecular_function owl:Class
GO:0016421 biolink:NamedThing CoA carboxylase activity Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti molecular_function owl:Class
GO:0018305 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide RESID:AA0288 biological_process owl:Class
GO:0006097 biolink:NamedThing glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. got7fsn_ti glyoxylate bypass MetaCyc:GLYOXYLATE-BYPASS|Wikipedia:Glyoxylate_cycle biological_process owl:Class
GO:0061678 biolink:NamedThing Entner-Doudoroff pathway A cellular carbohydrate catabolic process that converts a carbohydrate to pyruvate and either glyceraldehyde or glyceraldehyde-3 phosphate by dehydration and aldol cleavage via a gluconate or 6-phosphogluconate intermediate. got7fsn_ti dph 2015-01-16T15:28:25Z MetaCyc:Entner-Doudoroff-Pathways biological_process owl:Class
GO:1990404 biolink:NamedThing protein ADP-ribosylase activity The transfer, from NAD, of ADP-ribose to a protein amino acid residue. got7fsn_ti ribosylase activity pg 2014-06-24T07:04:44Z molecular_function owl:Class
GO:0018760 biolink:NamedThing thiocyanate hydrolase activity Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+). got7fsn_ti thiocyanate aminohydrolase activity EC:3.5.5.8|RHEA:21464|MetaCyc:RXN-1761|KEGG_REACTION:R05780|UM-BBD_reactionID:r0598 molecular_function owl:Class
GO:0016815 biolink:NamedThing hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN. got7fsn_ti EC:3.5.5.- molecular_function owl:Class
GO:0060431 biolink:NamedThing primary lung bud formation The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds. got7fsn_ti lung formation biological_process owl:Class
GO:0060572 biolink:NamedThing morphogenesis of an epithelial bud The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding. got7fsn_ti dph 2009-04-30T09:38:35Z biological_process owl:Class
GO:0003146 biolink:NamedThing heart jogging The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis. got7fsn_ti cardiac jogging tb 2009-09-22T06:11:41Z biological_process owl:Class
GO:0046252 biolink:NamedThing toluene biosynthetic process The chemical reactions and pathways resulting in the formation of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products. got7fsn_ti toluene synthesis|toluene formation|toluene biosynthesis|toluene anabolism This term was reinstated from obsolete. biological_process owl:Class
GO:0002151 biolink:NamedThing G-quadruplex RNA binding Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. got7fsn_ti G quartet RNA binding|G quartet binding|G-quartet binding|G quadruplex binding The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure. hjd 2009-10-22T01:38:02Z molecular_function owl:Class
GO:0006033 biolink:NamedThing chitin localization A process in which chitin is transported to, or maintained in, a specific location. got7fsn_ti establishment and maintenance of chitin localization|chitin localisation biological_process owl:Class
GO:0001094 biolink:NamedThing TFIID-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. got7fsn_ti TFIID-class transcription factor binding krc 2010-10-28T02:48:33Z molecular_function owl:Class
GO:0045507 biolink:NamedThing interleukin-25 receptor activity Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-25 receptor activity|IL-25R molecular_function owl:Class
GO:0102278 biolink:NamedThing N,N'-diacetylchitobiose synthase activity Catalysis of the reaction: n H2O + chitin <=> N,N'-diacetylchitobiose. got7fsn_ti MetaCyc:RXN-12554 molecular_function owl:Class
GO:0070064 biolink:NamedThing proline-rich region binding Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. got7fsn_ti molecular_function owl:Class
GO:0055120 biolink:NamedThing striated muscle dense body A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere. got7fsn_ti cellular_component owl:Class
GO:0001673 biolink:NamedThing male germ cell nucleus The nucleus of a male germ cell, a reproductive cell in males. got7fsn_ti male germ-cell nucleus GO:0043081 cellular_component owl:Class
GO:0043073 biolink:NamedThing germ cell nucleus The nucleus of a germ cell, a reproductive cell in multicellular organisms. got7fsn_ti germ-cell nucleus cellular_component owl:Class
GO:0042092 biolink:NamedThing type 2 immune response An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects. got7fsn_ti T-helper 2 type immune response|Th2 immune response biological_process owl:Class
GO:0033779 biolink:NamedThing 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity Catalysis of the reaction: 5beta-cholestane-3alpha,7alpha-diol + H(+) + NADPH + O(2) = 5beta-cholestane-3alpha,7alpha,12alpha-triol + H(2)O + NADP(+). got7fsn_ti 5beta-cholestane-3alpha,7alpha-diol 12alpha-monooxygenase activity|5beta-cholestane-3alpha,7alpha-diol,NADPH:oxygen oxidoreductase (12alpha-hydroxylating) activity|CYP8B1|sterol 12alpha-hydroxylase activity|cytochrome P450 8B1 MetaCyc:1.14.13.96-RXN|RHEA:15261|KEGG_REACTION:R07204|EC:1.14.14.139 molecular_function owl:Class
GO:0000330 biolink:NamedThing plant-type vacuole lumen The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana. got7fsn_ti lumen of vacuole with cell cycle-independent morphology cellular_component owl:Class
GO:0090549 biolink:NamedThing response to carbon starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source. got7fsn_ti tb 2013-04-22T13:57:16Z biological_process owl:Class
GO:0070256 biolink:NamedThing negative regulation of mucus secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. got7fsn_ti negative regulation of mucus production biological_process owl:Class
GO:0045822 biolink:NamedThing negative regulation of heart contraction Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. got7fsn_ti inhibition of heart contraction|down-regulation of heart contraction|downregulation of heart contraction|down regulation of heart contraction|negative regulation of cardiac contraction biological_process owl:Class
GO:0061281 biolink:NamedThing specification of mesonephric connecting tubule identity The process in which the connecting tubule of the mesonephric nephron acquires its identity. got7fsn_ti specification of mesonephric collecting tubule identity dph 2010-09-02T01:26:09Z biological_process owl:Class
GO:0072085 biolink:NamedThing specification of connecting tubule identity The process in which the connecting tubule of the kidney nephron acquires its identity. got7fsn_ti mah 2010-02-01T02:49:11Z biological_process owl:Class
GO:0080185 biolink:NamedThing effector-mediated induction of plant hypersensitive response by symbiont A symbiont process in which a molecule secreted by the symbiont activates a resistance gene-dependent defense response signaling pathway in the plant host, in order to activate a hypersensitive response to induce necrosis. In the plant, this process involves the direct or indirect recognition of the symbiont effector protein for example through plant resistance receptor or R proteins (or R genes). got7fsn_ti induction by organism of pathogen-race/host plant cultivar-specific resistance in host|positive regulation by organism of defense response in host by specific elicitors|positive regulation by symbiont of host resistance gene-dependent defense response|induction by organism of defense response in host by specific elicitors|induction by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction|avirulence protein|activation of hypersensitive response|activation by organism of defense response in host by specific elicitors|positive regulation by symbiont of plant hypersensitive response|ETI-triggered of host innate immune response|activation by organism of host resistance gene-dependent defense response|activation by symbiont of host resistance gene-dependent defense response|induction by symbiont of host resistance gene-dependent defense response|effector-triggered immunity|positive regulation by organism of host gene-for-gene resistance|necrotrophic effector|positive regulation by symbiont of plant HR|effector-triggered necrosis|induction by organism of host gene-for-gene resistance|activation by organism of host gene-for-gene resistance|activation of HR|effector-triggered induction of host innate immune response|effector-triggered induction of plant hypersensitive response by symbiont|induction of effector-triggered immunity (ETI)|ETI triggered of host innate immune response https://github.com/geneontology/go-ontology/issues/18694 dhl 2011-08-10T04:33:53Z GO:0052101|GO:0052286|GO:0052527|GO:0052423 Wikipedia:Effector-triggered_immunity biological_process owl:Class
GO:0052158 biolink:NamedThing modulation by symbiont of host resistance gene-dependent defense response Any process in which a symbiont modulates the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of host gene-for-gene resistance|modulation by organism of pathogen-race/host plant cultivar-specific resistance in symbiont|modulation by organism of defense response in host by specific elicitors|modulation by organism of resistance gene-dependent defense response of other organism involved in symbiotic interaction GO:0052297 biological_process owl:Class
GO:0002873 biolink:NamedThing positive regulation of natural killer cell tolerance induction Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction. got7fsn_ti up regulation of natural killer cell tolerance induction|activation of natural killer cell tolerance induction|positive regulation of NK cell tolerance induction|up-regulation of natural killer cell tolerance induction|upregulation of natural killer cell tolerance induction|stimulation of natural killer cell tolerance induction biological_process owl:Class
GO:0002673 biolink:NamedThing regulation of acute inflammatory response Any process that modulates the frequency, rate, or extent of an acute inflammatory response. got7fsn_ti biological_process owl:Class
GO:0050311 biolink:NamedThing sulfite reductase (ferredoxin) activity Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin. got7fsn_ti ferredoxin-sulfite reductase activity|sulphite reductase (ferredoxin) activity|hydrogen-sulfide:ferredoxin oxidoreductase activity MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN|EC:1.8.7.1|RHEA:23132 molecular_function owl:Class
GO:0016673 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. got7fsn_ti oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor EC:1.8.7.- molecular_function owl:Class
GO:0052920 biolink:NamedThing (2R)-2-hydroxy-2-methylbutanenitrile lyase activity Catalysis of the reaction: (2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide. got7fsn_ti MetaCyc:RXN-11733|RHEA:28170|KEGG_REACTION:R09358|EC:4.1.2.46 molecular_function owl:Class
GO:0097727 biolink:NamedThing blepharoplast An intracellular non-membrane-bounded organelle found in multi-ciliated sperm cells of some primitive land plants, and consisting of many radially arranged ninefold symmetric cylinders. The blepharoplast is involved in de novo formation of multiple centrioles; it enlarges and then disintegrates into many procentrioles, which elongate and ultimately nucleate cilia on the surface of the sperm cell. got7fsn_ti The blepharoplast should not be confused with a basal body; rather, it acts as the precursor assembly zone for multiple basal bodies. pr 2016-09-23T10:57:18Z cellular_component owl:Class
GO:0019654 biolink:NamedThing acetate fermentation The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP. got7fsn_ti MetaCyc:P142-PWY biological_process owl:Class
GO:0006083 biolink:NamedThing acetate metabolic process The chemical reactions and pathways involving acetate, the anion of acetic acid. got7fsn_ti acetate metabolism biological_process owl:Class
GO:0033571 biolink:NamedThing lactoferrin transport The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0006826 biolink:NamedThing iron ion transport The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti ferric iron transport|ferric ion import|iron transport|iron ion import|ferric ion transport|ferric iron uptake|ferrous iron transport|ferrous ion transport|ferric iron import pr 2012-04-18T03:33:45Z GO:0097286|GO:0015682|GO:0015681|GO:0033216|GO:0015684 biological_process owl:Class
GO:0052740 biolink:NamedThing 1-acyl-2-lysophosphatidylserine acylhydrolase activity Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate. got7fsn_ti phosphatidylserine-specific phospholipase A1 activity EC:3.1.1.32 molecular_function owl:Class
GO:0061812 biolink:NamedThing cyclic ADP-ribose hydrolase Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR). got7fsn_ti dph 2016-11-11T13:32:43Z molecular_function owl:Class
GO:0009664 biolink:NamedThing plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. got7fsn_ti plant-type cell wall organization and biogenesis|plant-type cell wall organisation|cellulose and pectin-containing cell wall organization and biogenesis|cell wall organization and biogenesis biological_process owl:Class
GO:0016754 biolink:NamedThing sinapoylglucose-malate O-sinapoyltransferase activity Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate. got7fsn_ti 1-sinapoylglucose-L-malate sinapoyltransferase activity|1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity|sinapoylglucose:malate sinapoyltransferase activity MetaCyc:2.3.1.92-RXN|EC:2.3.1.92|RHEA:12625|KEGG_REACTION:R03323 molecular_function owl:Class
GO:0016753 biolink:NamedThing O-sinapoyltransferase activity Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:1990102 biolink:NamedThing DnaA-DiaA complex A protein-DNA complex containing a tetramer of DiaA attached to multiple DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA. got7fsn_ti DnaA-DiaA-DNA complex bhm 2013-05-14T12:33:59Z cellular_component owl:Class
GO:1990077 biolink:NamedThing primosome complex Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms. Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart. got7fsn_ti primosome bhm 2013-04-26T11:55:28Z cellular_component owl:Class
GO:1900540 biolink:NamedThing fumonisin catabolic process The chemical reactions and pathways resulting in the breakdown of fumonisin. got7fsn_ti fumonisin degradation|fumonisin catabolism|fumonisin breakdown tb 2012-05-11T12:54:12Z biological_process owl:Class
GO:0035985 biolink:NamedThing senescence-associated heterochromatin focus A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes. got7fsn_ti senescence-associated heterochromatin foci|SAHF bf 2011-08-25T04:36:40Z cellular_component owl:Class
GO:0034230 biolink:NamedThing enkephalin processing The formation of mature enkephalin, a pentapeptide hormone involved in regulating pain and nociception in the body by proteolytic processing of enkephalin propeptide. got7fsn_ti enkephalin formation|peptide enkephalin formation|peptide enkephalin processing biological_process owl:Class
GO:0018276 biolink:NamedThing isopeptide cross-linking via N6-glycyl-L-lysine The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination. got7fsn_ti See also the biological process term 'peptide cross-linking via S-glycyl-L-cysteine ; GO:0018255'. RESID:AA0125 biological_process owl:Class
GO:0042794 biolink:NamedThing plastid rRNA transcription The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase. got7fsn_ti rRNA transcription from plastid promoter https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0042793 biolink:NamedThing plastid transcription The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase. got7fsn_ti transcription from plastid promoter https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0140643 biolink:NamedThing hydroxymethylglutaryl-CoA reductase (NADH) activity Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) <=> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH. got7fsn_ti beta-hydroxy-beta-methylglutaryl CoA-reductase activity|3-hydroxy-3-methylglutaryl coenzyme A reductase activity|beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity|hydroxymethylglutaryl coenzyme A reductase activity|HMG-CoA reductase activity https://github.com/geneontology/go-ontology/issues/21411 Note that this activity is not present in eukaryotes, see PMID:29224355. pg 2021-05-11T16:00:35Z KEGG_REACTION:R02081|MetaCyc:HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN|EC:1.1.1.88|RHEA:14833 molecular_function owl:Class
GO:0061180 biolink:NamedThing mammary gland epithelium development The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. got7fsn_ti breast epithelium development dph 2010-07-14T08:18:24Z biological_process owl:Class
GO:0060429 biolink:NamedThing epithelium development The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. got7fsn_ti biological_process owl:Class
GO:0097370 biolink:NamedThing protein O-GlcNAcylation via threonine The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine. got7fsn_ti pr 2012-08-06T16:57:37Z biological_process owl:Class
GO:0097669 biolink:NamedThing SCF-Skp2 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Skp2 in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:28:52Z cellular_component owl:Class
GO:0050316 biolink:NamedThing T2-induced deoxynucleotide kinase activity Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP. got7fsn_ti ATP:(d)NMP phosphotransferase activity EC:2.7.4.12|MetaCyc:GMKALT-RXN|RHEA:12697 molecular_function owl:Class
GO:0071479 biolink:NamedThing cellular response to ionizing radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. got7fsn_ti cellular response to ionizing radiation stimulus|cellular response to ionising radiation mah 2009-12-18T02:00:31Z biological_process owl:Class
GO:0004162 biolink:NamedThing dimethylnitrosamine demethylase activity Catalysis of the removal of a methyl group from N-nitrosodimethylamine. got7fsn_ti N-nitrosodimethylamine demethylase activity molecular_function owl:Class
GO:0032507 biolink:NamedThing maintenance of protein location in cell Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere. got7fsn_ti maintenance of protein localization in cell biological_process owl:Class
GO:0044364 biolink:NamedThing disruption of cells of other organism A process in which an organism has a negative effect on the functioning of the second organism's cells. got7fsn_ti jl 2011-10-27T02:27:48Z biological_process owl:Class
GO:0021844 biolink:NamedThing interneuron sorting involved in substrate-independent cerebral cortex tangential migration The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures. got7fsn_ti biological_process owl:Class
GO:0034715 biolink:NamedThing pICln-Sm protein complex A protein complex that contains pICln (CLNS1A) and several Sm proteins, including SmD1, SmD2, SmE, SmF, and SmG. got7fsn_ti 6S pICln complex cellular_component owl:Class
GO:0021960 biolink:NamedThing anterior commissure morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum. got7fsn_ti biological_process owl:Class
GO:0002335 biolink:NamedThing mature B cell differentiation The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen. got7fsn_ti mature B lymphocyte differentiation|mature cell development|mature B-cell differentiation|mature B-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0006424 biolink:NamedThing glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0007183 biolink:NamedThing SMAD protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. got7fsn_ti SMAD protein heteromerization biological_process owl:Class
GO:1990179 biolink:NamedThing protein localization to actomyosin contractile ring A process in which a protein is transported to, or maintained at, the actomyosin contractile ring. got7fsn_ti protein localisation to actomyosin contractile ring mah 2013-08-30T16:13:54Z biological_process owl:Class
GO:0071880 biolink:NamedThing adenylate cyclase-activating adrenergic receptor signaling pathway The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). got7fsn_ti adrenergic receptor, adenylate cyclase activating pathway|activation of adenylate cyclase activity by adrenergic receptor signalling pathway|adrenergic receptor, adenylyl cyclase activating pathway|activation of adenylate cyclase activity by adrenergic receptor signaling pathway mah 2010-09-13T04:21:28Z biological_process owl:Class
GO:0071875 biolink:NamedThing adrenergic receptor signaling pathway A series of molecular signals generated as a consequence of an adrenergic receptor binding to one of its physiological ligands. got7fsn_ti adrenoceptor signaling pathway|adrenergic receptor signalling pathway mah 2010-09-13T03:44:44Z biological_process owl:Class
GO:0047132 biolink:NamedThing dihydrobenzophenanthridine oxidase activity Catalysis of the reaction: O2 + dihydrosanguinarine = H2O2 + sanguinarine. got7fsn_ti dihydrobenzophenanthridine:oxygen oxidoreductase activity EC:1.5.3.12|MetaCyc:1.5.3.12-RXN|RHEA:16621 molecular_function owl:Class
GO:0071860 biolink:NamedThing proctolin receptor binding Binding to a proctolin receptor. got7fsn_ti mah 2010-09-10T03:24:19Z molecular_function owl:Class
GO:0097146 biolink:NamedThing NOXA-BCL-xl complex A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:49:00Z cellular_component owl:Class
GO:0019115 biolink:NamedThing benzaldehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+. got7fsn_ti EC:1.2.1.- molecular_function owl:Class
GO:0004030 biolink:NamedThing aldehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. got7fsn_ti ALDH|aldehyde:NAD(P)+ oxidoreductase activity MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN|Reactome:R-HSA-5692283|Reactome:R-HSA-5696080|Reactome:R-HSA-6808464|EC:1.2.1.5 molecular_function owl:Class
GO:0006999 biolink:NamedThing nuclear pore organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore. got7fsn_ti nuclear pore complex organization and biogenesis|nuclear pore organization and biogenesis|nuclear pore organisation biological_process owl:Class
GO:0046584 biolink:NamedThing enniatin metabolic process The chemical reactions and pathways involving enniatins, any of various cyclodepsipeptide antibiotics from Fusarium species that function as ionophores. got7fsn_ti enniatin metabolism biological_process owl:Class
GO:0061070 biolink:NamedThing female urethra development The progression of the female urethra over time from its initial formation to the mature structure. The female urethra is a renal system organ that carries urine from the bladder to outside the body, exiting above the vaginal opening. got7fsn_ti dph 2010-03-12T08:29:43Z biological_process owl:Class
GO:0061068 biolink:NamedThing urethra development The progression of the urethra over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. got7fsn_ti dph 2010-03-12T08:24:52Z biological_process owl:Class
GO:0000994 biolink:NamedThing RNA polymerase III core binding Binding to an RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. got7fsn_ti krc 2010-08-11T03:58:58Z molecular_function owl:Class
GO:0030744 biolink:NamedThing luteolin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+). got7fsn_ti o-diphenol m-O-methyltransferase activity|S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity|S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity|luteolin methyltransferase activity|o-dihydric phenol methyltransferase activity|o-dihydric phenol meta-O-methyltransferase activity|luteolin 3'-O-methyltransferase activity RHEA:14589|MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN|EC:2.1.1.42|KEGG_REACTION:R03587 molecular_function owl:Class
GO:0004787 biolink:NamedThing thiamine-diphosphatase activity Catalysis of the reaction: TPP + H2O = TMP + phosphate. got7fsn_ti TPPase activity|thiamin-pyrophosphatase activity|thiaminpyrophosphatase activity|thiamine pyrophosphatase activity|thiamin pyrophosphatase activity RHEA:27998 molecular_function owl:Class
GO:0050451 biolink:NamedThing CoA-disulfide reductase activity Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+. got7fsn_ti CoA-disulfide reductase (NAD(P)H) activity|coenzyme A disulfide reductase activity|CoA:NAD(P)+ oxidoreductase activity|NADH:CoA-disulfide oxidoreductase activity|CoA-disulfide reductase (NADH2)|CoA-disulfide reductase (NADH) activity|CoA:NAD+ oxidoreductase activity|CoADR activity|NADH2:CoA-disulfide oxidoreductase activity|CoA-disulfide reductase [NAD(P)H]|CoA-disulphide reductase activity EC:1.8.1.14|MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN|RHEA:14705 molecular_function owl:Class
GO:0052590 biolink:NamedThing sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity Catalysis of the reaction: sn-glycerol 3-phosphate + a ubiquinone = glycerone phosphate + a ubiquinol. got7fsn_ti Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. MetaCyc:RXN0-5258|EC:1.1.5.3 molecular_function owl:Class
GO:0004368 biolink:NamedThing glycerol-3-phosphate dehydrogenase (quinone) activity Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol. got7fsn_ti sn-glycerol-3-phosphate dehydrogenase activity|sn-glycerol-3-phosphate:quinone oxidoreductase activity|flavin-linked glycerol-3-phosphate dehydrogenase|glycerol-3-phosphate CoQ reductase|FAD-dependent glycerol-3-phosphate dehydrogenase|glycerophosphate dehydrogenase activity|L-glycerophosphate dehydrogenase activity Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. MetaCyc:RXN0-5260|Reactome:R-HSA-188467|MetaCyc:RXN-9927|RHEA:18977|EC:1.1.5.3 molecular_function owl:Class
GO:0032174 biolink:NamedThing cellular bud neck septin collar A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck. got7fsn_ti cellular_component owl:Class
GO:0007622 biolink:NamedThing rhythmic behavior The specific behavior of an organism that recur with measured regularity. got7fsn_ti rhythmic behaviour|rhythmic behavioral response to stimulus|rhythmic behavioural response to stimulus biological_process owl:Class
GO:0044545 biolink:NamedThing NSL complex A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1. got7fsn_ti non-specific lethal complex jl 2012-03-22T12:49:18Z cellular_component owl:Class
GO:0019665 biolink:NamedThing anaerobic amino acid catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP. got7fsn_ti amino acid fermentation biological_process owl:Class
GO:0001067 biolink:NamedThing transcription regulatory region nucleic acid binding Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. got7fsn_ti regulatory region nucleic acid binding https://github.com/geneontology/go-ontology/issues/20791 krc 2010-10-21T04:08:56Z molecular_function owl:Class
GO:0003676 biolink:NamedThing nucleic acid binding Binding to a nucleic acid. got7fsn_ti base pairing GO:0000496 molecular_function owl:Class
GO:0044059 biolink:NamedThing modulation by symbiont of host endocrine process The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism. got7fsn_ti regulation by symbiont of host endocrine process biological_process owl:Class
GO:0044060 biolink:NamedThing regulation of endocrine process Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. got7fsn_ti regulation of endocrine system process biological_process owl:Class
GO:0043165 biolink:NamedThing Gram-negative-bacterium-type cell outer membrane assembly The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. got7fsn_ti cell outer membrane biogenesis biological_process owl:Class
GO:0002746 biolink:NamedThing antigen processing and presentation following pinocytosis Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis. got7fsn_ti biological_process owl:Class
GO:0035516 biolink:NamedThing oxidative DNA demethylase activity Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O(2) = a nucleobase within DNA + formaldehyde + succinate + CO(2). got7fsn_ti N1-methyladenine demethylase activity|2-oxoglutarate-dependent DNA demethylase|N3-methylcytosine demethylase activity|1-ethyladenine demethylase activity https://github.com/geneontology/go-ontology/issues/21159 bf 2010-04-30T02:38:16Z GO:0103052|GO:0103051|GO:0103053 EC:1.14.11.33|MetaCyc:RXN0-985|MetaCyc:RXN0-984|RHEA:30299|MetaCyc:RXN0-986 molecular_function owl:Class
GO:0072714 biolink:NamedThing response to selenite ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus. got7fsn_ti mah 2012-04-19T02:46:28Z biological_process owl:Class
GO:0070944 biolink:NamedThing neutrophil-mediated killing of bacterium The directed killing of a bacterium by a neutrophil. got7fsn_ti neutrophil mediated killing of bacterium mah 2009-10-01T01:55:56Z biological_process owl:Class
GO:0070943 biolink:NamedThing neutrophil-mediated killing of symbiont cell The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti neutrophil mediated killing of symbiont cell mah 2009-10-01T01:52:03Z biological_process owl:Class
GO:0019237 biolink:NamedThing centromeric DNA binding Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. got7fsn_ti centromere binding molecular_function owl:Class
GO:1990837 biolink:NamedThing sequence-specific double-stranded DNA binding Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. got7fsn_ti sequence-specific dsDNA binding sl 2015-08-25T17:30:06Z molecular_function owl:Class
GO:0102667 biolink:NamedThing indole-3-acetyl-beta-1-D-glucose hydrolase activity Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose. got7fsn_ti MetaCyc:RXN-3165 molecular_function owl:Class
GO:0016788 biolink:NamedThing hydrolase activity, acting on ester bonds Catalysis of the hydrolysis of any ester bond. got7fsn_ti esterase activity Reactome:R-HSA-9023619|Reactome:R-HSA-162729|Reactome:R-HSA-9023617|EC:3.1.-.- molecular_function owl:Class
GO:0048459 biolink:NamedThing floral whorl structural organization The process that contributes to the act of creating the structural organization of the floral whorl. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti floral whorl structural organisation GO:0048416 biological_process owl:Class
GO:0070435 biolink:NamedThing Shc-EGFR complex A protein complex that contains the epidermal growth factor receptor (EGFR) and the adaptor protein Shc, and is involved in linking EGFR activation to the p21-Ras pathway. got7fsn_ti Shc-Egfr complex, EGF stimulated cellular_component owl:Class
GO:0010701 biolink:NamedThing positive regulation of norepinephrine secretion Any process that increases the frequency, rate or extent of the regulated release of norepinephrine. got7fsn_ti biological_process owl:Class
GO:0070531 biolink:NamedThing BRCA1-A complex A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. got7fsn_ti cellular_component owl:Class
GO:0072330 biolink:NamedThing monocarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. got7fsn_ti monocarboxylic acid synthesis|monocarboxylic acid biosynthesis|monocarboxylic acid anabolism|monocarboxylic acid formation mah 2010-11-02T04:51:32Z biological_process owl:Class
GO:0032787 biolink:NamedThing monocarboxylic acid metabolic process The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). got7fsn_ti monocarboxylic acid metabolism|monocarboxylate metabolic process biological_process owl:Class
GO:0047388 biolink:NamedThing [glutamine synthetase]-adenylyl-L-tyrosine phosphorylase Catalysis of the reaction: adenylyl-[L-glutamate:ammonia ligase (ADP-forming)] + H2O = AMP + [L-glutamate:ammonia ligase (ADP-forming)]. got7fsn_ti adenylyl(glutamine synthetase) hydrolase activity|adenylyl-glutamate-ammonia ligase hydrolase activity|adenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity|adenylyl-[glutamate-ammonia ligase] hydrolase activity|adenylyl-glutamine-synthetasehydrolase activity Formerly EC:3.1.4.15. RHEA:43716|EC:2.7.7.89|MetaCyc:3.1.4.15-RXN|KEGG_REACTION:R03474 molecular_function owl:Class
GO:0008787 biolink:NamedThing allose kinase activity Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate. got7fsn_ti allokinase activity|D-allokinase activity|ATP:D-allose 6-phosphotransferase activity|D-allose-6-kinase activity|allokinase (phosphorylating) MetaCyc:ALLOSE-KINASE-RXN|EC:2.7.1.55|RHEA:14805 molecular_function owl:Class
GO:0010285 biolink:NamedThing L,L-diaminopimelate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H(2)O + H(+). got7fsn_ti LL-diaminopimelate aminotransferase activity|LL-DAP aminotransferase activity|LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity|LL-diaminopimelate transaminase activity|LL-DAP-AT activity GO:0043742 KEGG_REACTION:R07613|EC:2.6.1.83|RHEA:23988|MetaCyc:RXN-7737 molecular_function owl:Class
GO:0072356 biolink:NamedThing chromosome passenger complex localization to kinetochore A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. got7fsn_ti chromosome passenger complex localisation to kinetochore|CPC localization to kinetochore|chromosomal passenger complex localization to kinetochore|CPC complex localization to kinetochore mah 2010-11-15T11:30:38Z biological_process owl:Class
GO:0045492 biolink:NamedThing xylan biosynthetic process The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone. got7fsn_ti xylan biosynthesis|xylan anabolism|xylan formation|xylan synthesis biological_process owl:Class
GO:0070592 biolink:NamedThing cell wall polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of a polysaccharide destined to form part of a cell wall. got7fsn_ti cell wall polysaccharide synthesis|cell wall polysaccharide anabolism|cell wall polysaccharide biosynthesis mah 2009-04-28T01:25:54Z biological_process owl:Class
GO:0070611 biolink:NamedThing histone methyltransferase activity (H3-R2 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 2) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 2). This reaction is the addition of a methyl group to arginine at position 2 of histone H3. got7fsn_ti histone-arginine N-methyltransferase activity (H3-R2 specific)|histone methylase activity (H3-R2 specific) mah 2009-04-29T02:04:44Z molecular_function owl:Class
GO:0003181 biolink:NamedThing atrioventricular valve morphogenesis The process in which the structure of the atrioventricular valve is generated and organized. got7fsn_ti AV valve morphogenesis dph 2009-10-08T11:31:59Z biological_process owl:Class
GO:0050863 biolink:NamedThing regulation of T cell activation Any process that modulates the frequency, rate or extent of T cell activation. got7fsn_ti regulation of T lymphocyte activation|regulation of T-lymphocyte activation|regulation of T-cell activation biological_process owl:Class
GO:0071258 biolink:NamedThing cellular response to gravity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. got7fsn_ti cellular response to gravitational stimulus mah 2009-12-04T03:31:36Z biological_process owl:Class
GO:0060641 biolink:NamedThing mammary gland duct regression in males The process in which the epithelium of the mammary duct is destroyed in males. got7fsn_ti dph 2009-05-20T04:50:57Z biological_process owl:Class
GO:0071104 biolink:NamedThing response to interleukin-9 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-9 stimulus. got7fsn_ti response to IL-9 mah 2009-11-09T12:50:25Z biological_process owl:Class
GO:0048924 biolink:NamedThing posterior lateral line neuromast mantle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. got7fsn_ti biological_process owl:Class
GO:0048888 biolink:NamedThing neuromast mantle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. got7fsn_ti biological_process owl:Class
GO:0034324 biolink:NamedThing O-hexanoyltransferase activity Catalysis of the transfer of a hexyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0034327 biolink:NamedThing hexanoyltransferase activity Catalysis of the transfer of a hexanoyl (CH3-[CH2]4-CO-) group to an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0003247 biolink:NamedThing post-embryonic cardiac muscle cell growth involved in heart morphogenesis The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart. got7fsn_ti dph 2009-10-13T11:50:29Z biological_process owl:Class
GO:0047475 biolink:NamedThing phenylacetate-CoA ligase activity Catalysis of the reaction: ATP + CoA + phenylacetate = AMP + diphosphate + H(+) + phenylacetyl-CoA. got7fsn_ti phenylacetyl-CoA ligase (AMP-forming)|phenacyl coenzyme A synthetase activity|phenylacetate:CoA ligase (AMP-forming)|PA-CoA ligase activity|phenylacetyl-CoA ligase activity KEGG_REACTION:R02539|MetaCyc:PHENYLACETATE--COA-LIGASE-RXN|EC:6.2.1.30|RHEA:20956 molecular_function owl:Class
GO:0071620 biolink:NamedThing phosphorylation of RNA polymerase II C-terminal domain serine 5 residues The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans). got7fsn_ti mah 2010-02-09T02:39:52Z biological_process owl:Class
GO:0070816 biolink:NamedThing phosphorylation of RNA polymerase II C-terminal domain The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex. got7fsn_ti generation of hyperphosphorylated CTD of RNA polymerase II|generation of II(0) form of RNA polymerase II|CTD domain phosphorylation of RNA polymerase II|hyperphosphorylation of RNA polymerase II C-terminal domain mah 2009-07-13T04:01:19Z GO:0016245 biological_process owl:Class
GO:1905742 biolink:NamedThing Ras guanyl-nucleotide exchange factor complex A protein complex which is capable of Ras guanyl-nucleotide exchange factor activity. got7fsn_ti rjd 2016-12-06T10:24:29Z cellular_component owl:Class
GO:0002104 biolink:NamedThing endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. got7fsn_ti biological_process owl:Class
GO:0002103 biolink:NamedThing endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. got7fsn_ti biological_process owl:Class
GO:0070260 biolink:NamedThing 5'-tyrosyl-DNA phosphodiesterase activity Catalysis of the hydrolysis of 5'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase II and DNA. got7fsn_ti See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. molecular_function owl:Class
GO:0004660 biolink:NamedThing protein farnesyltransferase activity Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. got7fsn_ti CAAX farnesyltransferase activity|protein-cysteine farnesyltransferase activity|farnesyl-diphosphate:protein-cysteine farnesyltransferase activity|FTase activity The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate. GO:0018223 Reactome:R-HSA-9647978|Reactome:R-HSA-2530501|RHEA:13345|MetaCyc:2.5.1.58-RXN|EC:2.5.1.58 molecular_function owl:Class
GO:0140590 biolink:NamedThing effector-mediated suppression of host defenses A process mediated by a molecule secreted by a symbiont that results in the supression of a defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti effector-mediated suppression of host defenses by symbiont https://github.com/geneontology/go-ontology/issues/20813 pg 2021-02-08T07:26:05Z biological_process owl:Class
GO:0071024 biolink:NamedThing SL snRNP A ribonucleoprotein complex that contains spliced leader (SL) RNA and associated proteins. got7fsn_ti mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0042126 biolink:NamedThing nitrate metabolic process The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid. got7fsn_ti nitrate metabolism biological_process owl:Class
GO:0003033 biolink:NamedThing detection of hypoxic conditions in blood by aortic body chemoreceptor signaling The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies. got7fsn_ti detection of hypoxic conditions in blood by aortic body chemoreceptor signalling biological_process owl:Class
GO:0002007 biolink:NamedThing detection of hypoxic conditions in blood by chemoreceptor signaling The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies. got7fsn_ti detection of hypoxic conditions in blood by chemoreceptor signalling biological_process owl:Class
GO:0016661 biolink:NamedThing oxidoreductase activity, acting on other nitrogenous compounds as donors Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors EC:1.7.-.- molecular_function owl:Class
GO:0032143 biolink:NamedThing single thymine insertion binding Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine. got7fsn_ti molecular_function owl:Class
GO:0102308 biolink:NamedThing erythromycin D 3''-o-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin D <=> S-adenosyl-L-homocysteine + erythromycin B + H+. got7fsn_ti EC:2.1.1.254|MetaCyc:RXN-12924|RHEA:32651 molecular_function owl:Class
GO:0032517 biolink:NamedThing SOD1-calcineurin complex A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1. got7fsn_ti cellular_component owl:Class
GO:0008327 biolink:NamedThing methyl-CpG binding Binding to a methylated cytosine/guanine dinucleotide. got7fsn_ti molecular_function owl:Class
GO:0050741 biolink:NamedThing protein-FMN linkage via O3-riboflavin phosphoryl-L-serine The formation of a protein-FMN linkage via O3-riboflavin phosphoryl-L-serine. got7fsn_ti RESID:AA0350 biological_process owl:Class
GO:0004757 biolink:NamedThing sepiapterin reductase activity Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+. got7fsn_ti 7,8-dihydrobiopterin:NADP+ oxidoreductase activity MetaCyc:SEPIAPTERIN-REDUCTASE-RXN|RHEA:18953|Reactome:R-HSA-1497869|EC:1.1.1.153|Reactome:R-HSA-1475414 molecular_function owl:Class
GO:0047927 biolink:NamedThing gibberellin-44 dioxygenase activity Catalysis of the reaction: gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2. got7fsn_ti (gibberellin-44), 2-oxoglutarate:oxygen oxidoreductase activity|oxygenase, gibberellin A44 oxidase activity|gibberellin A44 oxidase activity|(gibberellin-44),2-oxoglutarate:oxygen oxidoreductase activity EC:1.14.11.12|MetaCyc:RXN1F-168|RHEA:16033 molecular_function owl:Class
GO:0050964 biolink:NamedThing detection of electrical stimulus involved in electroception The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal. got7fsn_ti detection of electrical stimulus during electroreception|electroception, detection of electrical stimulus|sensory transduction of electrical stimulus during electroception|electroception, sensory transduction of electrical stimulus|electroception, sensory detection of electrical stimulus|electroception, sensory transduction|sensory detection of electrical stimulus during electroception biological_process owl:Class
GO:0061132 biolink:NamedThing pancreas induction The close range interaction of two or more cells or tissues that causes the cells of the gut to change their fates and specify the development of the pancreas. got7fsn_ti dph 2010-05-17T09:45:32Z biological_process owl:Class
GO:0042118 biolink:NamedThing endothelial cell activation The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti biological_process owl:Class
GO:1903143 biolink:NamedThing adrenomedullin receptor complex A transmembrane, G protein-coupled signalling receptor complex which is capable of adrenomedullin receptor activity. got7fsn_ti adrenomedullin receptor AM1 complex|adrenomedullin receptor AM2 complex An example of this is RAMP2 in human (O60895) in PMID:22102369 (inferred from direct assay). bhm 2014-07-02T08:56:47Z cellular_component owl:Class
GO:0038037 biolink:NamedThing G protein-coupled receptor dimeric complex A protein complex that contains two G protein-coupled receptors. got7fsn_ti GPCR dimer|G-protein coupled receptor dimer|G-protein coupled receptor dimeric complex bf 2011-11-02T04:42:44Z cellular_component owl:Class
GO:0043015 biolink:NamedThing gamma-tubulin binding Binding to the microtubule constituent protein gamma-tubulin. got7fsn_ti gamma tubulin binding molecular_function owl:Class
GO:0015631 biolink:NamedThing tubulin binding Binding to monomeric or multimeric forms of tubulin, including microtubules. got7fsn_ti molecular_function owl:Class
GO:0044358 biolink:NamedThing envenomation resulting in hemorrhagic damage to other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism. got7fsn_ti jl 2011-10-26T04:24:59Z biological_process owl:Class
GO:0038179 biolink:NamedThing neurotrophin signaling pathway A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons. got7fsn_ti neurotrophin receptor signaling pathway There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors. bf 2013-03-27T17:22:44Z biological_process owl:Class
GO:0035107 biolink:NamedThing appendage morphogenesis The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch. got7fsn_ti biological_process owl:Class
GO:1902432 biolink:NamedThing protein localization to division septum A process in which a protein is transported to, or maintained in, a location within a division septum. got7fsn_ti protein localization in division septum|protein localisation to division septum|protein localisation in division septum mah 2013-09-30T14:29:51Z biological_process owl:Class
GO:0046951 biolink:NamedThing ketone body biosynthetic process The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA. got7fsn_ti ketone body biosynthesis|ketone body synthesis|ketone body anabolism|ketone body formation biological_process owl:Class
GO:0042381 biolink:NamedThing hemolymph coagulation Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response. got7fsn_ti hemolymph clotting biological_process owl:Class
GO:0007599 biolink:NamedThing hemostasis The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. got7fsn_ti Wikipedia:Hemostasis biological_process owl:Class
GO:0034521 biolink:NamedThing 1-naphthoic acid dioxygenase activity Catalysis of the reaction: 1-naphthoic acid + NADH + O2 + H+ = cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene + NAD+. got7fsn_ti EC:1.14.12.-|UM-BBD_reactionID:r0773 molecular_function owl:Class
GO:0071617 biolink:NamedThing lysophospholipid acyltransferase activity Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. got7fsn_ti mah 2010-02-08T04:53:37Z molecular_function owl:Class
GO:0062011 biolink:NamedThing mitochondrial respiratory chain complex IV pre-assembly complex A protein complex that contributes to and regulates mitochondrial respiratory chain complex IV (COX) formation. It acts by regulating mitochondrial COX1 translation and by promoting the assembly of COX components. got7fsn_ti COX1 preassemply complex|COX pre-assemply complex dph 2018-02-28T14:50:26Z cellular_component owl:Class
GO:0101031 biolink:NamedThing chaperone complex A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. got7fsn_ti An example of this is HSP90AB1 in human (P08238) in PMID:21855797 (inferred from direct assay). cellular_component owl:Class
GO:0015190 biolink:NamedThing L-leucine transmembrane transporter activity Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. got7fsn_ti L-leucine transporter activity|leucine/valine/isoleucine permease activity|leucine/isoleucine/valine porter activity molecular_function owl:Class
GO:0050890 biolink:NamedThing cognition The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory. got7fsn_ti Wikipedia:Cognition biological_process owl:Class
GO:0098819 biolink:NamedThing depolarization of postsynaptic membrane A process that depolarizes a postsynaptic membrane relative to its resting potential. This has an excitatory effect on the post-synaptic cell, moving the membrane potential towards the firing threshold. got7fsn_ti biological_process owl:Class
GO:0060078 biolink:NamedThing regulation of postsynaptic membrane potential Any process that modulates the potential difference across a post-synaptic membrane. got7fsn_ti regulation of post-synaptic membrane potential biological_process owl:Class
GO:0005212 biolink:NamedThing structural constituent of eye lens The action of a molecule that contributes to the structural integrity of the lens of an eye. got7fsn_ti molecular_function owl:Class
GO:0043820 biolink:NamedThing propionyl-CoA dehydrogenase activity Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA. got7fsn_ti EC:1.3.99.- molecular_function owl:Class
GO:1990064 biolink:NamedThing ground tissue pattern formation The regionalization process that gives rise to the patterning of the ground tissue. got7fsn_ti ground tissue patterning tb 2013-03-21T23:24:44Z biological_process owl:Class
GO:1990212 biolink:NamedThing positive regulation by symbiont of ethylene levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-09T19:03:10Z biological_process owl:Class
GO:0052024 biolink:NamedThing positive regulation by symbiont of hormone or growth regulator levels in host The increase by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti upregulation by symbiont of hormone or growth regulator levels in host|stimulation by symbiont of hormone or growth regulator levels in host|activation by symbiont of hormone or growth regulator levels in host|up-regulation by symbiont of hormone or growth regulator levels in host|positive modulation of hormone or growth regulator levels in host|positive regulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction|up regulation by symbiont of hormone or growth regulator levels in host GO:0052513 biological_process owl:Class
GO:0035458 biolink:NamedThing cellular response to interferon-beta Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. got7fsn_ti cellular response to beta-1 interferon|cellular response to fibroblast interferon|cellular response to fiblaferon bf 2010-04-16T11:10:40Z biological_process owl:Class
GO:0035070 biolink:NamedThing salivary gland histolysis The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly. got7fsn_ti salivary gland regression biological_process owl:Class
GO:0016796 biolink:NamedThing exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. got7fsn_ti exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters Note that this activity can catalyze cleavage of DNA or RNA. EC:3.1.15.- molecular_function owl:Class
GO:0030892 biolink:NamedThing mitotic cohesin complex A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex. got7fsn_ti cellular_component owl:Class
GO:0008278 biolink:NamedThing cohesin complex A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). got7fsn_ti cohesin core heterodimer|14S cohesin|SMC/kleisin ring complex|9S cohesin|SMC complex|Smc1-Smc3 complex GO:0008280|GO:0043222|GO:0008279 cellular_component owl:Class
GO:0090700 biolink:NamedThing maintenance of plant organ identity The process in which the identity of a plant organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti tb 2016-08-29T15:01:08Z biological_process owl:Class
GO:0035944 biolink:NamedThing perforin production The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. bf 2011-07-27T11:44:21Z biological_process owl:Class
GO:0043228 biolink:NamedThing non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. got7fsn_ti biological condensate|non-membrane-enclosed organelle https://github.com/geneontology/go-ontology/issues/21881 NIF_Subcellular:sao1456184038 cellular_component owl:Class
GO:0019629 biolink:NamedThing propionate catabolic process, 2-methylcitrate cycle The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle. got7fsn_ti propionate degradation, 2-methylcitrate cycle|propionate breakdown, 2-methylcitrate cycle biological_process owl:Class
GO:0019543 biolink:NamedThing propionate catabolic process The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid. got7fsn_ti propionate breakdown|propionate catabolism|propionate degradation biological_process owl:Class
GO:0031579 biolink:NamedThing membrane raft organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. got7fsn_ti lipid raft organization|membrane raft organization and biogenesis|membrane raft organisation biological_process owl:Class
GO:0014028 biolink:NamedThing notochord formation The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column. got7fsn_ti biological_process owl:Class
GO:0000953 biolink:NamedThing branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids. got7fsn_ti branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway biological_process owl:Class
GO:0009932 biolink:NamedThing cell tip growth Growth that occurs specifically at the tip of a cell. got7fsn_ti biological_process owl:Class
GO:0062200 biolink:NamedThing RAM/MOR signaling pathway An intracellular signaling pathway that regulates interphase polarized growth and cell separation at the end of cytokinesis through activation of the NDR1/2-related kinase. got7fsn_ti morphogenesis Orb6 network|RAM signaling pathway|MOR signaling pathway dph 2019-12-17T20:21:12Z biological_process owl:Class
GO:1900030 biolink:NamedThing regulation of pectin biosynthetic process Any process that modulates the frequency, rate or extent of pectin biosynthetic process. got7fsn_ti regulation of pectin biosynthesis|regulation of pectin formation|regulation of pectin anabolism|regulation of pectin synthesis tb 2012-01-13T02:03:37Z biological_process owl:Class
GO:0015183 biolink:NamedThing L-aspartate transmembrane transporter activity Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. got7fsn_ti glutamate/aspartate:sodium symporter activity|L-aspartate transporter activity|glutamate/aspartate porter activity molecular_function owl:Class
GO:0015172 biolink:NamedThing acidic amino acid transmembrane transporter activity Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3. got7fsn_ti acidic amino acid transporter activity Reactome:R-HSA-372448 molecular_function owl:Class
GO:0031797 biolink:NamedThing type 2 metabotropic GABA receptor binding Binding to a type 2 metabotropic GABA receptor. got7fsn_ti type 2 metabotropic GABA receptor ligand molecular_function owl:Class
GO:0031795 biolink:NamedThing G protein-coupled GABA receptor binding Binding to a G protein-coupled (metabotropic) GABA receptor. got7fsn_ti G-protein coupled GABA receptor binding|GABAB receptor binding|metabotropic GABA receptor binding|metabotropic GABA receptor ligand molecular_function owl:Class
GO:0052843 biolink:NamedThing inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. got7fsn_ti ai 2011-12-05T10:42:00Z MetaCyc:RXN-10977 molecular_function owl:Class
GO:0061622 biolink:NamedThing glycolytic process through glucose-1-phosphate The chemical reactions and pathways through a glucose-1-phosphate intermediate that result in the catabolism of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. got7fsn_ti dph 2014-04-28T08:08:01Z biological_process owl:Class
GO:0097256 biolink:NamedThing phenyllactate dehydrogenase activity Catalysis of the reaction: (R)-3-phenyllactate + NAD+ = 3-phenylpyruvate + H+ + NADH. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21412 This enzymatic activity is usually negligible, but may become prominent when phenylalanine levels are abnormally high as in the human disease phenylketonuria (PKU). pr 2012-03-07T11:39:39Z RHEA:38351|EC:1.1.1.110 molecular_function owl:Class
GO:0048575 biolink:NamedThing short-day photoperiodism, flowering A change from vegetative to reproductive phase as a result of detection of, or exposure to, a period of light that falls short of the critical day length. The critical day length varies between species. Although the term is short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 minus the critical day length. got7fsn_ti short-day photoperiodic control of flowering|short-day photoperiodic control of flowering time|long-night photoperiodism, flowering|short-day photoperiodic control of inflorescence development|response to long-night, flowering|response to short-day, flowering biological_process owl:Class
GO:0048573 biolink:NamedThing photoperiodism, flowering A change from the vegetative to the reproductive phase as a result of detection of, or exposure to, a period of light or dark of a given length. The length of the period of light or dark required to initiate the change is set relative to a particular duration known as the 'critical day length'. The critical day length varies between species. got7fsn_ti response to photoperiod, flowering|response to night length, flowering|photoperiodic control of flowering time|photoperiodic control of inflorescence development|response to day length, flowering biological_process owl:Class
GO:0034499 biolink:NamedThing late endosome to Golgi transport The directed movement of substances from late endosomes to the Golgi. got7fsn_ti prevacuolar endosome to Golgi transport|PVE to Golgi transport biological_process owl:Class
GO:0033746 biolink:NamedThing histone H3-methyl-arginine-2 demethylase activity Catalysis of the removal of the methyl group from a modified arginine residue at position 2 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone H3R2me demethylase activity|histone demethylase activity (H3-R2 specific) https://github.com/geneontology/go-ontology/issues/21089 molecular_function owl:Class
GO:0046678 biolink:NamedThing response to bacteriocin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacteriocin stimulus. A bacteriocin is a protein substance released by certain bacteria that kills but does not lyse closely related strains of bacteria. Specific bacteriocins attach to specific receptors on cell walls and induce specific metabolic block, e.g. cessation of nucleic acid or protein synthesis of oxidative phosphorylation. got7fsn_ti bacteriocin susceptibility/resistance biological_process owl:Class
GO:0103037 biolink:NamedThing L-glyceraldehyde 3-phosphate reductase activity Catalysis of the reaction: sn-glycerol 3-phosphate + NADP = H+ + L-glyceraldehyde 3-phosphate + NADPH. got7fsn_ti MetaCyc:RXN0-5410 molecular_function owl:Class
GO:0120208 biolink:NamedThing telodendria Telodendria are projections that originate from the axon pedicle and form gap junctions with other neurons. got7fsn_ti krc 2019-05-20T23:50:28Z cellular_component owl:Class
GO:0036086 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter in response to iron deficiency bf 2012-01-05T01:45:26Z biological_process owl:Class
GO:0033217 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. got7fsn_ti regulation of transcription from RNA polymerase II promoter in response to iron deficiency biological_process owl:Class
GO:0018828 biolink:NamedThing halohydrin hydrogen-halide-lyase A activity Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane. got7fsn_ti UM-BBD_enzymeID:e0048 molecular_function owl:Class
GO:0019181 biolink:NamedThing halohydrin hydrogen-halide-lyase activity Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide. got7fsn_ti molecular_function owl:Class
GO:0090294 biolink:NamedThing nitrogen catabolite activation of transcription A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources. got7fsn_ti positive regulation of transcription by nitrogen catabolites tb 2010-02-24T02:31:53Z biological_process owl:Class
GO:0033403 biolink:NamedThing UUA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UUA codon. got7fsn_ti leucine tRNA|TTA codon-amino acid adaptor activity Note that in the standard genetic code, TTA codes for leucine. molecular_function owl:Class
GO:0030869 biolink:NamedThing RENT complex A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit. got7fsn_ti cellular_component owl:Class
GO:0005677 biolink:NamedThing chromatin silencing complex Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing. got7fsn_ti cellular_component owl:Class
GO:0035366 biolink:NamedThing negative regulation of thymine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti negative regulation of 5-methyluracil transport bf 2010-03-11T10:23:42Z biological_process owl:Class
GO:0032240 biolink:NamedThing negative regulation of nucleobase-containing compound transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport biological_process owl:Class
GO:0034299 biolink:NamedThing reproductive blastospore formation The formation of a spore following the marked enlargement of part of a cell before separation by a septum. Blastospores are a type of asexual spore found in some fungi, most notably the class Glomeromycota. got7fsn_ti blastoconidium formation Note that this term should not be confused with the usage of 'blastospore' to mean any yeast-form fungal cell, as in Candida species. biological_process owl:Class
GO:0048315 biolink:NamedThing conidium formation The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. got7fsn_ti conidia biosynthesis|conidia formation biological_process owl:Class
GO:0030766 biolink:NamedThing 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline. got7fsn_ti 11-demethyl-17-deacetylvindoline 11-methyltransferase activity|S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity|tabersonine 16-O-methyltransferase activity|S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity RHEA:20992|EC:2.1.1.94|MetaCyc:2.1.1.94-RXN molecular_function owl:Class
GO:0097351 biolink:NamedThing toxin sequestering activity Binding to a toxic protein, disabling its function. There may be more than one antitoxin to a toxic protein. Instances of this activity are known only in prokaryotes, where the toxic protein may be a ribonuclease, a DNA gyrase, or other. got7fsn_ti toxin-antitoxin pair type I binding|toxin-antitoxin pair type II binding pr 2012-06-28T11:41:38Z molecular_function owl:Class
GO:0047470 biolink:NamedThing (1,4)-alpha-D-glucan 1-alpha-D-glucosylmutase activity Catalysis of the reaction: 4-[(1->4)-alpha-D-glucosyl](n-1)-D-glucose = 1-alpha-D-[(1->4)-alpha-D-glucosyl](n-1)-alpha-D-glucopyranoside. got7fsn_ti (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase|malto-oligosyltrehalose synthase activity|maltodextrin alpha-D-glucosyltransferase activity RHEA:13621|MetaCyc:5.4.99.15-RXN|EC:5.4.99.15 molecular_function owl:Class
GO:0061402 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to acidic pH Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter in response to acidity dph 2012-01-10T03:06:32Z biological_process owl:Class
GO:0071468 biolink:NamedThing cellular response to acidic pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti cellular response to acidity This term should be used to annotate instances where a cell is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0071229 'cellular response to acid chemical'. mah 2009-12-18T11:42:35Z biological_process owl:Class
GO:0070537 biolink:NamedThing histone H2A K63-linked deubiquitination A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX. got7fsn_ti biological_process owl:Class
GO:0070536 biolink:NamedThing protein K63-linked deubiquitination A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein. got7fsn_ti biological_process owl:Class
GO:0071406 biolink:NamedThing cellular response to methylmercury Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. got7fsn_ti cellular response to MeHg+|cellular response to CH3-Hg+ mah 2009-12-14T02:55:12Z biological_process owl:Class
GO:0051597 biolink:NamedThing response to methylmercury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylmercury stimulus. got7fsn_ti response to CH3-Hg+|response to MeHg+ biological_process owl:Class
GO:0097229 biolink:NamedThing sperm end piece The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane. got7fsn_ti pr 2012-01-25T01:29:04Z cellular_component owl:Class
GO:0120202 biolink:NamedThing rod photoreceptor disc membrane Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment. got7fsn_ti krc 2019-05-07T23:27:06Z cellular_component owl:Class
GO:0050009 biolink:NamedThing isopropanol dehydrogenase (NADP+) activity Catalysis of the reaction: NADP(+) + propan-2-ol = acetone + H(+) + NADPH. got7fsn_ti propan-2-ol:NADP+ oxidoreductase activity RHEA:21792|MetaCyc:ISOPROPANOL-DEHYDROGENASE-NADP+-RXN|EC:1.1.1.80|KEGG_REACTION:R01550 molecular_function owl:Class
GO:0047178 biolink:NamedThing glycerophospholipid acyltransferase (CoA-dependent) activity Catalysis of the reaction: 1-radyl-2-lyso-sn-glycero-3-phosphoethanolamine + 1-radyl-2-acyl-sn-glycero-3-phosphocholine = 1-radyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acyl-sn-glycero-3-phosphoethanolamine. got7fsn_ti 1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent) MetaCyc:2.3.1.148-RXN|EC:2.3.1.148|RHEA:20972 molecular_function owl:Class
GO:0034274 biolink:NamedThing Atg12-Atg5-Atg16 complex A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p. got7fsn_ti cellular_component owl:Class
GO:0045787 biolink:NamedThing positive regulation of cell cycle Any process that activates or increases the rate or extent of progression through the cell cycle. got7fsn_ti up regulation of progression through cell cycle|activation of progression through cell cycle|positive regulation of progression through cell cycle|upregulation of progression through cell cycle|stimulation of progression through cell cycle|positive regulation of cell cycle progression|up-regulation of progression through cell cycle biological_process owl:Class
GO:0060908 biolink:NamedThing plasmid copy number maintenance The maintenance of the number of copies of extrachromosomal plasmid DNA. got7fsn_ti dph 2009-09-04T02:49:08Z biological_process owl:Class
GO:0006276 biolink:NamedThing plasmid maintenance The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division. got7fsn_ti biological_process owl:Class
GO:0033645 biolink:NamedThing host cell endomembrane system A collection of membranous structures involved in transport within the host cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cellular_component owl:Class
GO:0008568 biolink:NamedThing microtubule-severing ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. got7fsn_ti katanin activity|ATP phosphohydrolase (tubulin-dimerizing) See also the cellular component term 'katanin complex ; GO:0008352'. EC:5.6.1.1|Reactome:R-HSA-9668419|MetaCyc:3.6.4.3-RXN molecular_function owl:Class
GO:0043654 biolink:NamedThing recognition of apoptotic cell The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis. got7fsn_ti detection of apoptotic cell|detection of apoptotic cell corpse|recognition of cell corpse|recognition of apoptotic cell corpse|detection of cell corpse biological_process owl:Class
GO:0006910 biolink:NamedThing phagocytosis, recognition The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell. got7fsn_ti recognition of phagocytosed substance by phagocytic cell Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'. biological_process owl:Class
GO:0033795 biolink:NamedThing betaine reductase activity Catalysis of the reaction: acetyl phosphate + trimethylamine + thioredoxin disulfide = N,N,N-trimethylglycine + phosphate + thioredoxin. got7fsn_ti acetyl-phosphate trimethylamine:thioredoxin disulfide oxidoreductase (N,N,N-trimethylglycine-forming) activity EC:1.21.4.4|RHEA:11848 molecular_function owl:Class
GO:0050485 biolink:NamedThing oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide. got7fsn_ti oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulphide as acceptor EC:1.21.4.- molecular_function owl:Class
GO:0000161 biolink:NamedThing osmosensory signaling MAPK cascade A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K. got7fsn_ti osmolarity sensing, activation of MAPKKK activity|activation of MAPKKK activity involved in osmosensory signaling pathway|Hog1 MAPK pathway|inactivation of MAPK activity involved in osmosensory signaling pathway|termination of MAPK activity during osmolarity sensing|osmolarity sensing, MAPKKK cascade|MAPKKK cascade involved in osmosensory signalling pathway|activation of MAPK activity involved in osmosensory signaling pathway|High Osmolarity Glycerol (HOG) MAPK pathway|MAPK cascade involved in osmosensory signaling pathway|activation of MAPKKK activity during osmolarity sensing|osmolarity sensing, activation of MAP kinase kinase kinase activity|activation of MAPKK activity during osmolarity sensing|activation of Pbs2 kinase|osmolarity sensing, activation of MAP kinase kinase activity|MAPKKK cascade involved in osmosensory signaling pathway|osmolarity sensing, activation of MAPK activity|activation of MAPKK activity involved in osmosensory signaling pathway|MAPKKK cascade during osmolarity sensing|Hog1/Sty1 stress-activated MAPK cascade|osmolarity sensing, activation of MAPKK activity https://github.com/geneontology/go-ontology/issues/20380 GO:0000173|GO:0000167|GO:0000168|GO:0000169|GO:0007233 biological_process owl:Class
GO:0007231 biolink:NamedThing osmosensory signaling pathway The series of molecular signals initiated in response to osmotic change. got7fsn_ti osmolarity sensing signalling pathway|osmolarity sensing|signal transduction during osmotic stress|osmolarity sensing signaling pathway|osmosensory signalling pathway|osmosensory signal transduction https://github.com/geneontology/go-ontology/issues/20368 biological_process owl:Class
GO:0019900 biolink:NamedThing kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. got7fsn_ti molecular_function owl:Class
GO:0051216 biolink:NamedThing cartilage development The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. got7fsn_ti cartilage formation|chondrogenesis|cartilage organ development|cartilage biosynthesis|cartilage element development|cartilage biogenesis Wikipedia:Chondrogenesis biological_process owl:Class
GO:0047262 biolink:NamedThing polygalacturonate 4-alpha-galacturonosyltransferase activity Catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP. got7fsn_ti uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity|UDP galacturonate-polygalacturonate alpha-galacturonosyltransferase activity|UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase activity GO:0050375 EC:2.4.1.43|MetaCyc:2.4.1.43-RXN|RHEA:13573 molecular_function owl:Class
GO:0097298 biolink:NamedThing regulation of nucleus size Any process that modulates the size of the nucleus. got7fsn_ti regulation of nuclear size|regulation of nuclear volume pr 2012-05-03T06:21:43Z biological_process owl:Class
GO:0090714 biolink:NamedThing innate immunity memory response An immune response mediated by the innate immune system and directed against a previously encountered immunologic stimulus, being quicker and quantitatively better compared with the initial response to that stimulus. got7fsn_ti tb 2016-11-11T12:23:03Z biological_process owl:Class
GO:0070696 biolink:NamedThing transmembrane receptor protein serine/threonine kinase binding Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity. got7fsn_ti mah 2009-06-04T03:57:42Z molecular_function owl:Class
GO:0002946 biolink:NamedThing tRNA C5-cytosine methylation The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine. got7fsn_ti tRNA 5-methylcytosine biosynthesis hjd 2012-12-07T14:23:13Z biological_process owl:Class
GO:0042492 biolink:NamedThing gamma-delta T cell differentiation The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex. got7fsn_ti gamma-delta T-cell differentiation|gamma-delta T-lymphocyte differentiation|gamma-delta T lymphocyte differentiation|gamma-delta T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0030653 biolink:NamedThing beta-lactam antibiotic metabolic process The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. got7fsn_ti beta-lactam antibiotic metabolism biological_process owl:Class
GO:0072338 biolink:NamedThing cellular lactam metabolic process The chemical reactions and pathways involving lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. got7fsn_ti cellular lactam metabolism mah 2010-11-04T04:31:21Z biological_process owl:Class
GO:0060157 biolink:NamedThing urinary bladder development The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion. got7fsn_ti biological_process owl:Class
GO:0043407 biolink:NamedThing negative regulation of MAP kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity. got7fsn_ti inhibition of MAPK activity|down-regulation of MAPK activity|downregulation of MAPK activity|down regulation of MAPK activity|negative regulation of mitogen-activated protein kinase activity|negative regulation of mitogen activated protein kinase activity biological_process owl:Class
GO:0061897 biolink:NamedThing all-trans retinal 3,4-desaturase activity Catalysis of the reaction: all-trans-retinal + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized [adrenodoxin]. got7fsn_ti dph 2017-06-12T14:56:58Z molecular_function owl:Class
GO:0014899 biolink:NamedThing cardiac muscle atrophy A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation. got7fsn_ti biological_process owl:Class
GO:0009765 biolink:NamedThing photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. got7fsn_ti energy dissipation biological_process owl:Class
GO:0045844 biolink:NamedThing positive regulation of striated muscle tissue development Any process that activates or increases the frequency, rate or extent of striated muscle development. got7fsn_ti up-regulation of striated muscle development|activation of striated muscle development|stimulation of striated muscle development|upregulation of striated muscle development|up regulation of striated muscle development biological_process owl:Class
GO:0048636 biolink:NamedThing positive regulation of muscle organ development Any process that activates, maintains or increases the rate of muscle development. got7fsn_ti up regulation of muscle development|up-regulation of muscle development|upregulation of muscle development|activation of muscle development|stimulation of muscle development biological_process owl:Class
GO:0071599 biolink:NamedThing otic vesicle development The process whose specific outcome is the progression of the otic vesicle over time, from its formation to the mature structure. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. got7fsn_ti mah 2010-02-04T04:07:17Z biological_process owl:Class
GO:0051683 biolink:NamedThing establishment of Golgi localization The directed movement of the Golgi to a specific location. got7fsn_ti establishment of Golgi body localization|establishment of Golgi apparatus localization|establishment of Golgi localisation biological_process owl:Class
GO:0031076 biolink:NamedThing embryonic camera-type eye development The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure. got7fsn_ti embryonic eye development biological_process owl:Class
GO:0106117 biolink:NamedThing acidocalcisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an acidocalcisome. An acidocalcisome is an electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. got7fsn_ti acidocalcisome organisation|volutin granule organization|polyphosphate vacuole organization|acidocalcisome organization and biogenesis|metachromatic granule organization|acidocalcisome biogenesis hjd 2018-04-19T17:18:01Z biological_process owl:Class
GO:0071946 biolink:NamedThing cis-acting DNA replication termination A DNA replication termination process that is initiated by protein binding to a binding site on the same chromosome, but remote from the termination site, via DNA looping or chromosome kissing. got7fsn_ti cis acting DNA replication termination mah 2010-10-06T01:08:48Z biological_process owl:Class
GO:0046945 biolink:NamedThing N-terminal peptidyl-alanine N-carbamoylation The carbamylation of the N-terminal alanine of proteins to form the derivative N-carbamoyl-L-alanine. got7fsn_ti N-terminal peptidyl-alanine N-carbamylation RESID:AA0343 biological_process owl:Class
GO:0033934 biolink:NamedThing glucan 1,4-alpha-maltotriohydrolase activity Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotriose residues from the non-reducing chain ends. got7fsn_ti 1,4-alpha-D-glucan maltotriohydrolase activity|exo-maltotriohydrolase activity|maltotriohydrolase activity MetaCyc:3.2.1.116-RXN|EC:3.2.1.116 molecular_function owl:Class
GO:0052876 biolink:NamedThing methylamine dehydrogenase (amicyanin) activity Catalysis of the reaction: 2O + methylamine + 2 oxidized [amicyanin] = formaldehyde + 2 H+ + NH4+ + 2 reduced [amicyanin]. got7fsn_ti primary-amine dehydrogenase|methylamine:amicyanin oxidoreductase (deaminating) activity|methylamine dehydrogenase activity|amine dehydrogenase|MADH activity https://github.com/geneontology/go-ontology/issues/21650 RHEA:30207|KEGG_REACTION:R00606|UM-BBD_reactionID:r0075|EC:1.4.9.1 molecular_function owl:Class
GO:0090018 biolink:NamedThing posterior neural plate formation The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate. got7fsn_ti tb 2009-07-29T11:32:08Z biological_process owl:Class
GO:0033714 biolink:NamedThing secondary-alcohol oxidase activity Catalysis of the reaction: O(2) + secondary alcohol = H(2)O(2) + ketone. got7fsn_ti secondary-alcohol:oxygen oxidoreductase activity|secondary alcohol oxidase activity|polyvinyl alcohol oxidase activity KEGG_REACTION:R02277|MetaCyc:SECONDARY-ALCOHOL-OXIDASE-RXN|EC:1.1.3.18|RHEA:23180 molecular_function owl:Class
GO:0097384 biolink:NamedThing cellular lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells. got7fsn_ti cellular lipid synthesis|cellular lipid anabolism|cellular lipid biosynthesis|cellular lipid formation pr 2012-10-16T16:47:09Z biological_process owl:Class
GO:0098882 biolink:NamedThing structural constituent of presynaptic active zone The action of a molecule that contributes to the structural integrity of a presynaptic active zone. got7fsn_ti structural constituent of active zone molecular_function owl:Class
GO:0010354 biolink:NamedThing homogentisate prenyltransferase activity Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid. got7fsn_ti molecular_function owl:Class
GO:0030308 biolink:NamedThing negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth. got7fsn_ti inhibition of cell growth|down regulation of cell growth|downregulation of cell growth|down-regulation of cell growth biological_process owl:Class
GO:0010234 biolink:NamedThing anther wall tapetum cell fate specification The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti tapetal cell fate specification biological_process owl:Class
GO:0047999 biolink:NamedThing hyponitrite reductase activity Catalysis of the reaction: 2 hydroxylamine + 2 NAD(+) = 2 H(+) + hyponitrous acid + 2 NADH. got7fsn_ti NADH2:hyponitrite oxidoreductase activity|NADH:hyponitrite oxidoreductase activity|hydroxylamine:NAD+ oxidoreductase activity MetaCyc:HYPONITRITE-REDUCTASE-RXN|EC:1.7.1.5|KEGG_REACTION:R00023|RHEA:19337 molecular_function owl:Class
GO:0031326 biolink:NamedThing regulation of cellular biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. got7fsn_ti regulation of cellular synthesis|regulation of cellular biosynthesis|regulation of cellular formation|regulation of cellular anabolism biological_process owl:Class
GO:0010643 biolink:NamedThing cell communication by chemical coupling The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels. got7fsn_ti biological_process owl:Class
GO:0043783 biolink:NamedThing oxidoreductase activity, acting on metal ions, flavin as acceptor Catalysis of an oxidation-reduction in which the metal ion is reduced and flavin acts as an electron acceptor. got7fsn_ti oxidoreductase activity, oxidizing metal ions with flavin as acceptor|oxidoreductase activity, reducing metal ions, flavin as acceptor https://github.com/geneontology/go-ontology/issues/20675|https://github.com/geneontology/go-ontology/issues/20682 EC:1.16.8.- molecular_function owl:Class
GO:0016722 biolink:NamedThing oxidoreductase activity, acting on metal ions Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. got7fsn_ti oxidoreductase activity, reducing metal ions|oxidoreductase activity, oxidizing metal ions https://github.com/geneontology/go-ontology/issues/20675 EC:1.16.-.-|Reactome:R-HSA-917805 molecular_function owl:Class
GO:0034409 biolink:NamedThing ascospore wall (1->3)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores. got7fsn_ti ascospore wall 1,3-beta-glucan metabolic process|ascospore wall beta-1,3 glucan metabolism|ascospore wall 1,3-beta-D-glucan metabolic process|ascospore wall beta-1,3 glucan metabolic process|ascospore wall 1,3-beta-glucan metabolism biological_process owl:Class
GO:0010344 biolink:NamedThing seed oilbody biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination. got7fsn_ti seed oil body organization|spherosome biogenesis|oleosome biogenesis biological_process owl:Class
GO:0070342 biolink:NamedThing brown fat cell proliferation The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species. got7fsn_ti brown adipose cell proliferation|brown adipocyte proliferation biological_process owl:Class
GO:0000720 biolink:NamedThing pyrimidine dimer repair by nucleotide-excision repair The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. got7fsn_ti Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'. biological_process owl:Class
GO:0006289 biolink:NamedThing nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). got7fsn_ti pyrimidine-dimer repair, DNA damage excision|NER|intrastrand cross-link repair Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. GO:0045001 biological_process owl:Class
GO:0000837 biolink:NamedThing Doa10p ubiquitin ligase complex A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p. got7fsn_ti Ssm4p ubiquitin ligase complex cellular_component owl:Class
GO:0000835 biolink:NamedThing ER ubiquitin ligase complex A ubiquitin ligase complex found in the ER. got7fsn_ti cellular_component owl:Class
GO:0018788 biolink:NamedThing atrazine chlorohydrolase activity Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+). got7fsn_ti AtzA MetaCyc:3.8.1.8-RXN|UM-BBD_reactionID:r0113|KEGG_REACTION:R05558|EC:3.8.1.8|RHEA:11312 molecular_function owl:Class
GO:0106157 biolink:NamedThing peptidyl-arginine 3-dioxygenase activity Catalyzes the reaction: 2-oxoglutarate + [protein]-L-arginine + O2 = [protein]-(3R)-3-hydroxy-L-arginine + CO2 + succinate. got7fsn_ti L-arginine 3-hydroxylase activity https://github.com/geneontology/go-ontology/issues/16689 hjd 2018-11-26T15:05:57Z GO:0140554 RHEA:56744 molecular_function owl:Class
GO:0001992 biolink:NamedThing regulation of systemic arterial blood pressure by vasopressin The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport. got7fsn_ti blood pressure regulation by vasopressin|vasopressin control of blood pressure biological_process owl:Class
GO:0031011 biolink:NamedThing Ino80 complex A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity. got7fsn_ti INO80 chromatin remodeling complex cellular_component owl:Class
GO:0097346 biolink:NamedThing INO80-type complex A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. got7fsn_ti pr 2012-06-20T11:26:55Z cellular_component owl:Class
GO:0006024 biolink:NamedThing glycosaminoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars. got7fsn_ti glycosaminoglycan synthesis|glycosaminoglycan formation|glycosaminoglycan anabolism|glycosaminoglycan biosynthesis biological_process owl:Class
GO:0030203 biolink:NamedThing glycosaminoglycan metabolic process The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties. got7fsn_ti glycosaminoglycan metabolism biological_process owl:Class
GO:0002768 biolink:NamedThing immune response-regulating cell surface receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response. got7fsn_ti immune response-regulating cell surface receptor signalling pathway biological_process owl:Class
GO:0032593 biolink:NamedThing insulin-responsive compartment A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2. got7fsn_ti IRC|GSC|GLUT4 storage compartment cellular_component owl:Class
GO:1900100 biolink:NamedThing positive regulation of plasma cell differentiation Any process that activates or increases the frequency, rate or extent of plasma cell differentiation. got7fsn_ti up regulation of plasma cell differentiation|up-regulation of plasma cell development|activation of plasma cell differentiation|up-regulation of plasma cell differentiation|upregulation of plasma cell differentiation|activation of plasma cell development|up regulation of plasma cell development|upregulation of plasma cell development|positive regulation of plasma cell development bf 2012-02-15T10:46:08Z biological_process owl:Class
GO:0070878 biolink:NamedThing primary miRNA binding Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. got7fsn_ti pri-miRNA binding|primary microRNA binding mah 2009-08-20T04:11:36Z molecular_function owl:Class
GO:0071694 biolink:NamedThing maintenance of protein location in extracellular region Any process in which a protein is maintained in a specific location within the extracellular region and is prevented from moving elsewhere. got7fsn_ti mah 2010-02-25T04:04:41Z biological_process owl:Class
GO:0018508 biolink:NamedThing cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+. got7fsn_ti benzoate cis-diol dehydrogenase activity UM-BBD_enzymeID:e0219 molecular_function owl:Class
GO:0008084 biolink:NamedThing imaginal disc growth factor receptor binding Binding to an imaginal disc growth factor receptor. got7fsn_ti imaginal disc growth factor molecular_function owl:Class
GO:0002355 biolink:NamedThing detection of tumor cell The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0052164 biolink:NamedThing symbiont defense to host-produced reactive oxygen species Any process in which a symbiont modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of defense-related host reactive oxygen intermediate production|modulation by organism of defense-related host oxidative burst|response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction|evasion or tolerance of defense-related host oxidative burst|evasion or tolerance by organism of host-produced reactive oxygen species|evasion or tolerance by organism of reactive oxygen species produced during host defense response|evasion by symbiont of cellular damage caused by host oxidative burst|modulation by organism of defense-related host active oxygen species production|modulation by symbiont of defense-related host reactive oxygen species production|modulation by organism of defense-related host ROI production|evasion or tolerance by symbiont of host-produced reactive oxygen species|modulation by organism of defense-related host ROS production|evasion or tolerance of host-produced active oxygen species|evasion or tolerance of host-produced reactive oxygen intermediates|modulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction|evasion or tolerance of reactive oxygen species produced by host|evasion or tolerance of host-produced ROIs|modulation by organism of defense-related host respiratory burst|modulation by organism of defense-related host metabolic burst|modulation by organism of defense-related host reactive oxidative species production|evasion or tolerance by organism of reactive oxygen species produced by other organism involved in symbiotic interaction|evasion or tolerance of host-produced ROS|evasion or tolerance by symbiont of reactive oxygen species produced by other organism involved in symbiotic interaction|evasion or tolerance of defense-related host metabolic burst|evasion or tolerance of defense-related host respiratory burst|modulation by organism of defense-related host AOS production|evasion or tolerance of host-produced AOS|response to defense-related host reactive oxygen species production https://github.com/geneontology/go-ontology/issues/18697 GO:0052567|GO:0052303|GO:0052059|GO:0052550|GO:0052385 biological_process owl:Class
GO:0072244 biolink:NamedThing metanephric glomerular epithelium development The process whose specific outcome is the progression of the metanephric glomerular epithelium over time, from its formation to the mature structure. The metanephric glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus in the metanephros. The metanephric glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. got7fsn_ti mah 2010-03-19T03:38:47Z biological_process owl:Class
GO:0072207 biolink:NamedThing metanephric epithelium development The process whose specific outcome is the progression of an epithelium in the metanephros over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. got7fsn_ti mah 2010-03-18T11:50:37Z biological_process owl:Class
GO:0009922 biolink:NamedThing fatty acid elongase activity Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C). got7fsn_ti Reactome:R-HSA-548800|Reactome:R-HSA-548830|MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN|Reactome:R-HSA-2046094|Reactome:R-HSA-548815|Reactome:R-HSA-548814|Reactome:R-HSA-2046095|Reactome:R-HSA-2046090|Reactome:R-HSA-2046083|Reactome:R-HSA-2046100|Reactome:R-HSA-2046088 molecular_function owl:Class
GO:0007304 biolink:NamedThing chorion-containing eggshell formation The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster. got7fsn_ti eggshell formation biological_process owl:Class
GO:0030703 biolink:NamedThing eggshell formation Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration. got7fsn_ti biological_process owl:Class
GO:0036172 biolink:NamedThing thiamine salvage A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis. got7fsn_ti bf 2012-03-29T10:31:05Z MetaCyc:PWY-6897|MetaCyc:PWY-6898|MetaCyc:PWY-6896 biological_process owl:Class
GO:0009228 biolink:NamedThing thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. got7fsn_ti thiamine biosynthesis|vitamin B1 biosynthesis|thiamine formation|vitamin B1 biosynthetic process|thiamin anabolism|thiamine synthesis|thiamin biosynthetic process MetaCyc:THISYN-PWY biological_process owl:Class
GO:0098765 biolink:NamedThing meiosis II cell cycle phase A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division). got7fsn_ti This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0010313 biolink:NamedThing phytochrome binding Binding to a phytochrome. got7fsn_ti molecular_function owl:Class
GO:0039579 biolink:NamedThing suppression by virus of host ISG15 activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives. got7fsn_ti bf VZ:723 biological_process owl:Class
GO:0039507 biolink:NamedThing suppression by virus of host molecular function Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein. got7fsn_ti inhibition of host protein function|down-regulation by virus of host protein function|negative regulation by virus of host protein function|down regulation by virus of host protein function|inhibition by virus of host protein function|negative regulation by virus of host molecular function bf 2011-06-02T02:47:03Z biological_process owl:Class
GO:0009904 biolink:NamedThing chloroplast accumulation movement The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis. got7fsn_ti low-fluence-rate response biological_process owl:Class
GO:0042976 biolink:NamedThing activation of Janus kinase activity The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. got7fsn_ti activation of JAK protein by tyrosine phosphorylation|tyrosine phosphorylation of JAK2 protein|tyrosine phosphorylation of JAK1 protein|tyrosine phosphorylation of JAK protein|activation of JAK1 protein|activation of JAK2 protein|activation of JAK1 kinase activity|positive regulation of JAK protein activity by tyrosine phosphorylation|activation of JAK2 kinase activity|activation of JAK protein GO:0042977|GO:0010531 biological_process owl:Class
GO:0030163 biolink:NamedThing protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. got7fsn_ti pheromone catabolic process|protein catabolism|protein breakdown|pheromone catabolism|protein degradation|multicellular organismal protein catabolic process This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. GO:0044254 Wikipedia:Protein_catabolism biological_process owl:Class
GO:0005771 biolink:NamedThing multivesicular body A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. got7fsn_ti MVB|MVE|multivesicular endosome NIF_Subcellular:sao2045955158 cellular_component owl:Class
GO:0005770 biolink:NamedThing late endosome A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. got7fsn_ti PVC|prevacuolar compartment NIF_Subcellular:nlx_subcell_20090702 cellular_component owl:Class
GO:0015425 biolink:NamedThing ATPase-coupled nonpolar-amino acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in). got7fsn_ti leucine/isoleucine/valine porter activity|ATP-dependent nonpolar-amino acid transporter activity|nonpolar-amino acid-transporting ATPase activity|nonpolar-amino acid ABC transporter|nonpolar-amino-acid-transporting ATPase activity|nonpolar amino acid-transporting ATPase activity MetaCyc:3.6.3.22-RXN|TC:3.A.1.4.1|EC:7.4.2.2 molecular_function owl:Class
GO:0016241 biolink:NamedThing regulation of macroautophagy Any process that modulates the frequency, rate or extent of macroautophagy. got7fsn_ti regulation of starvation-induced autophagy biological_process owl:Class
GO:0003092 biolink:NamedThing renal water retention The process in which renal water excretion is decreased. got7fsn_ti negative regulation of renal water excretion biological_process owl:Class
GO:0035811 biolink:NamedThing negative regulation of urine volume Any process that decreases the amount of urine excreted from the body over a unit of time. got7fsn_ti reduction of urinary volume|decrease in urine flow|antidiuresis bf 2011-04-20T01:21:01Z biological_process owl:Class
GO:0021705 biolink:NamedThing locus ceruleus formation The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. got7fsn_ti biological_process owl:Class
GO:0034614 biolink:NamedThing cellular response to reactive oxygen species Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. got7fsn_ti cellular response to ROS|cellular response to AOS|cellular response to reactive oxygen intermediate|cellular response to active oxygen species|cellular response to ROI|cellular response to reactive oxidative species biological_process owl:Class
GO:0009378 biolink:NamedThing four-way junction helicase activity Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. got7fsn_ti ATP-dependent four-way junction helicase activity|Holliday junction helicase activity|ATP-dependent four-way junction DNA helicase activity|ATP-dependent Holliday junction helicase activity pr 2013-08-07T13:36:54Z GO:1990163 molecular_function owl:Class
GO:0033453 biolink:NamedThing GCU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCU codon. got7fsn_ti alanine tRNA|GCT codon-amino acid adaptor activity Note that in the standard genetic code, GCT codes for alanine. molecular_function owl:Class
GO:0010439 biolink:NamedThing regulation of glucosinolate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. got7fsn_ti biological_process owl:Class
GO:0071829 biolink:NamedThing plasma lipoprotein particle disassembly The disaggregation of a plasma lipoprotein particle into its constituent components. got7fsn_ti mah 2010-09-08T11:14:21Z biological_process owl:Class
GO:0071827 biolink:NamedThing plasma lipoprotein particle organization A protein-lipid complex subunit organization process that results in the formation, disassembly, or alteration of a plasma lipoprotein particle. A plasma lipoprotein particle is a spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. got7fsn_ti plasma lipoprotein particle organisation mah 2010-09-08T10:32:26Z biological_process owl:Class
GO:0047146 biolink:NamedThing sterigmatocystin 7-O-methyltransferase activity Catalysis of the reaction: sterigmatocystin + S-adenosyl-L-methionine = 7-O-methylsterigmatocystin + S-adenosyl-homocysteine. got7fsn_ti O-methyltransferase II activity|S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase activity|sterigmatocystin methyltransferase activity|S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase activity|sterigmatocystin 8-O-methyltransferase activity RHEA:15561|EC:2.1.1.110|MetaCyc:2.1.1.110-RXN molecular_function owl:Class
GO:1990948 biolink:NamedThing ubiquitin ligase inhibitor activity Binds to and stops, prevents or reduces the activity of a ubiquitin ligase. got7fsn_ti APC-Cdc20 complex inhibitor activity|mitotic anaphase-promoting complex inhibitor activity vw 2016-04-21T16:36:54Z GO:0061637|GO:0090645 molecular_function owl:Class
GO:0097250 biolink:NamedThing mitochondrial respirasome assembly The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex. got7fsn_ti mitochondrial respiratory chain supercomplex assembly|mitochondrial respiratory supercomplex assembly https://github.com/geneontology/go-ontology/issues/12846 pr 2012-02-23T05:18:41Z biological_process owl:Class
GO:0009440 biolink:NamedThing cyanate catabolic process The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid. got7fsn_ti cyanate degradation|cyanate breakdown|cyanate catabolism biological_process owl:Class
GO:1901441 biolink:NamedThing poly(hydroxyalkanoate) biosynthetic process The chemical reactions and pathways resulting in the formation of poly(hydroxyalkanoate). got7fsn_ti poly(hydroxyalkanoate) biosynthesis|poly(hydroxyalkanoate) formation|poly(hydroxyalkanoate) synthesis|poly(hydroxyalkanoate) anabolism tt 2012-10-02T01:48:33Z biological_process owl:Class
GO:0031583 biolink:NamedThing phospholipase D-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA). got7fsn_ti activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway|phospholipase D-activating G-protein coupled receptor signaling pathway|G-protein signalling, phospholipase D activating pathway This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase D (PLD) activation. biological_process owl:Class
GO:0006627 biolink:NamedThing protein processing involved in protein targeting to mitochondrion The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments. got7fsn_ti mitochondrial processing|mitochondrial protein processing during import biological_process owl:Class
GO:0034982 biolink:NamedThing mitochondrial protein processing The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import. got7fsn_ti mitochondrial protein modification biological_process owl:Class
GO:0038162 biolink:NamedThing erythropoietin-mediated signaling pathway A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti EPO-R signaling pathway|erythropoietin receptor signaling pathway bf 2012-05-14T02:28:38Z biological_process owl:Class
GO:0050744 biolink:NamedThing protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine The formation of a protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine. got7fsn_ti RESID:AA0353 biological_process owl:Class
GO:0036527 biolink:NamedThing peptidyl-arginine deglycation The removal of a sugar or dicarbonyl from an arginine residue of a glycated protein. got7fsn_ti deglycation of N-acetylarginine bf 2016-08-04T10:36:30Z biological_process owl:Class
GO:0036525 biolink:NamedThing protein deglycation The removal of a sugar or dicarbonyl from a glycated protein. got7fsn_ti glycated protein repair Glycation is a non enzymatic covalent addition of a sugar or dicarbonyl (methylglyoxal, glyoxal) to a protein. Deglycation repairs the glycated amino acids. bf 2016-08-04T10:28:54Z biological_process owl:Class
GO:0061735 biolink:NamedThing DNM1L-mediated stimulation of mitophagy in response to mitochondrial depolarization A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a DNM1L-family molecule. got7fsn_ti dynamin-like protein-mediated stimulation of mitophagy in response to mitochondrial depolarization dph 2015-09-14T14:00:43Z biological_process owl:Class
GO:0098779 biolink:NamedThing positive regulation of mitophagy in response to mitochondrial depolarization Any process that activates or increases the frequency, rate or extent of mitophagy in response to mitochondrial depolarization. got7fsn_ti positive regulation of macromitophagy in response to mitochondrial depolarization biological_process owl:Class
GO:2001154 biolink:NamedThing regulation of glycolytic fermentation to ethanol Any process that modulates the frequency, rate or extent of glucose catabolic process to ethanol. got7fsn_ti regulation of ethanol fermentation|regulation of glucose fermentation to ethanol mcc 2011-10-27T02:39:00Z biological_process owl:Class
GO:0035219 biolink:NamedThing prothoracic disc development Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle. got7fsn_ti biological_process owl:Class
GO:0031295 biolink:NamedThing T cell costimulation The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation. got7fsn_ti T-cell costimulation|T lymphocyte costimulation|T-cell co-stimulation|T cell co-stimulation|T-lymphocyte costimulation biological_process owl:Class
GO:0002388 biolink:NamedThing immune response in Peyer's patch Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine. got7fsn_ti biological_process owl:Class
GO:0002387 biolink:NamedThing immune response in gut-associated lymphoid tissue Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules. got7fsn_ti immune response in GALT biological_process owl:Class
GO:0019456 biolink:NamedThing L-cysteine catabolic process via cystine, using cysteine transaminase The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3). got7fsn_ti L-cysteine breakdown via cystine, using cysteine transaminase|L-cysteine degradation via cystine, using cysteine transaminase biological_process owl:Class
GO:0043551 biolink:NamedThing regulation of phosphatidylinositol 3-kinase activity Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring. got7fsn_ti regulation of phosphoinositide 3-kinase activity biological_process owl:Class
GO:0000145 biolink:NamedThing exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. got7fsn_ti Sec6/8 complex|exocyst complex Wikipedia:Exocyst cellular_component owl:Class
GO:0044560 biolink:NamedThing envenomation resulting in modulation of ion channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism. got7fsn_ti envenomation resulting in regulation of ion channel activity in other organism jl 2012-04-05T03:46:35Z biological_process owl:Class
GO:0022855 biolink:NamedThing protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti glucose PTS transporter activity molecular_function owl:Class
GO:0008625 biolink:NamedThing extrinsic apoptotic signaling pathway via death domain receptors A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered. got7fsn_ti death receptor-mediated apoptosis|induction of apoptosis via death receptors|induction of apoptosis via death domain receptors Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013. biological_process owl:Class
GO:0043421 biolink:NamedThing anthranilate catabolic process The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate). got7fsn_ti 2-aminobenzoate degradation|ortho-aminobenzoic acid catabolism|anthranilate breakdown|ortho-aminobenzoic acid catabolic process|2-aminobenzoate catabolic process|anthranilate degradation|anthranilic acid catabolic process|anthranilate catabolism|2-aminobenzoate catabolism|anthranilic acid catabolism|2-aminobenzoate breakdown GO:0019259 MetaCyc:2AMINOBENZDEG-PWY biological_process owl:Class
GO:0010103 biolink:NamedThing stomatal complex morphogenesis The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells. got7fsn_ti biological_process owl:Class
GO:1990612 biolink:NamedThing Sad1-Kms1 LINC complex A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair. got7fsn_ti jl 2015-01-20T13:10:49Z cellular_component owl:Class
GO:0034993 biolink:NamedThing meiotic nuclear membrane microtubule tethering complex A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links links the nuclear lumen to cytoplasmic microtubules during meiosis. got7fsn_ti LINC complex|SUN-KASH complex|LInker of Nucleoskeleton and Cytoskeleton complex cellular_component owl:Class
GO:0102783 biolink:NamedThing beta-carotene oxygenase activity Catalysis of the reaction: beta-carotene + 2 O2 = 2 beta-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. got7fsn_ti MetaCyc:RXN-7883 molecular_function owl:Class
GO:0000463 biolink:NamedThing maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0007096 biolink:NamedThing regulation of exit from mitosis Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity. got7fsn_ti biological_process owl:Class
GO:1901990 biolink:NamedThing regulation of mitotic cell cycle phase transition Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition. got7fsn_ti mitotic cell cycle control jl 2013-03-19T16:14:38Z biological_process owl:Class
GO:0047736 biolink:NamedThing cellobiose epimerase activity Catalysis of the reaction: cellobiose = D-glucosyl-D-mannose. got7fsn_ti cellobiose 2-epimerase activity EC:5.1.3.11|MetaCyc:CELLOBIOSE-EPIMERASE-RXN|RHEA:23384 molecular_function owl:Class
GO:0061439 biolink:NamedThing kidney vasculature morphogenesis The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form. got7fsn_ti dph 2012-03-08T12:30:11Z biological_process owl:Class
GO:0010437 biolink:NamedThing 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond. got7fsn_ti molecular_function owl:Class
GO:0045902 biolink:NamedThing negative regulation of translational fidelity Any process that decreases the ability of the translational apparatus to interpret the genetic code. got7fsn_ti downregulation of translational fidelity|inhibition of translational fidelity|down-regulation of translational fidelity|down regulation of translational fidelity biological_process owl:Class
GO:0017148 biolink:NamedThing negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. got7fsn_ti protein biosynthetic process inhibitor activity|down-regulation of protein biosynthetic process|negative regulation of protein synthesis|downregulation of protein biosynthetic process|negative regulation of protein anabolism|down regulation of protein biosynthetic process|inhibition of protein biosynthetic process|negative regulation of protein biosynthetic process|negative regulation of protein formation|protein biosynthesis inhibitor activity|negative regulation of protein biosynthesis GO:0016478 biological_process owl:Class
GO:0035089 biolink:NamedThing establishment of apical/basal cell polarity The specification and formation of the polarity of a cell along its apical/basal axis. got7fsn_ti biological_process owl:Class
GO:0036467 biolink:NamedThing 5-hydroxy-L-tryptophan decarboxylase activity Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin. got7fsn_ti 5-hydroxytryptophan decarboxylase activity bf 2014-07-21T09:22:24Z RHEA:18533 molecular_function owl:Class
GO:0004058 biolink:NamedThing aromatic-L-amino-acid decarboxylase activity Catalysis of the reaction: L-amino acid + H+ = R-H + CO2. got7fsn_ti aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)|aromatic-L-amino-acid carboxy-lyase activity|tryptophan decarboxylase activity|L-DOPA decarboxylase activity|aromatic amino acid decarboxylase activity|5-hydroxytryptophan decarboxylase activity|DOPA decarboxylase activity|hydroxytryptophan decarboxylase activity GO:0016400 EC:4.1.1.28|MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN|Reactome:R-HSA-209859|Reactome:R-HSA-209924 molecular_function owl:Class
GO:0039573 biolink:NamedThing suppression by virus of host complement activation Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase. got7fsn_ti inhibition of host complement activation by virus|inhibition of host complement cascade by virus|inhibition of host complement factors by virus bf VZ:811 biological_process owl:Class
GO:0043103 biolink:NamedThing hypoxanthine salvage Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis. got7fsn_ti guanine, xanthine and their nucleoside salvage|adenine, hypoxanthine and their nucleoside salvage biological_process owl:Class
GO:0043096 biolink:NamedThing purine nucleobase salvage Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis. got7fsn_ti purine base salvage biological_process owl:Class
GO:0002442 biolink:NamedThing serotonin secretion involved in inflammatory response The regulated release of serotonin by a cell as part of an inflammatory response. got7fsn_ti serotonin release involved in inflammatory response|serotonin secretion involved in acute inflammatory response biological_process owl:Class
GO:0021795 biolink:NamedThing cerebral cortex cell migration The orderly movement of cells from one site to another in the cerebral cortex. got7fsn_ti biological_process owl:Class
GO:0080167 biolink:NamedThing response to karrikin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a karrikin stimulus. Karrikins are signaling molecules in smoke from burning vegetation that trigger seed germination for many angiosperms (flowering plants). got7fsn_ti dhl 2010-09-23T05:07:22Z biological_process owl:Class
GO:0009628 biolink:NamedThing response to abiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus. got7fsn_ti response to abiotic stress https://github.com/geneontology/go-ontology/issues/16572 Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. biological_process owl:Class
GO:0009955 biolink:NamedThing adaxial/abaxial pattern specification The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. got7fsn_ti adaxial/abaxial pattern formation biological_process owl:Class
GO:0015188 biolink:NamedThing L-isoleucine transmembrane transporter activity Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid. got7fsn_ti leucine/isoleucine/valine porter activity|isoleucine/valine:sodium symporter activity|leucine/valine/isoleucine permease activity|L-isoleucine transporter activity molecular_function owl:Class
GO:0033598 biolink:NamedThing mammary gland epithelial cell proliferation The multiplication or reproduction of mammary gland epithelial cells, resulting in the expansion of a cell population. Mammary gland epithelial cells make up the covering of surfaces of the mammary gland. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. got7fsn_ti biological_process owl:Class
GO:0003279 biolink:NamedThing cardiac septum development The progression of a cardiac septum over time, from its initial formation to the mature structure. got7fsn_ti heart septum development dph 2009-10-20T09:45:13Z biological_process owl:Class
GO:1903942 biolink:NamedThing positive regulation of respiratory gaseous exchange Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange. got7fsn_ti up-regulation of respiratory gaseous exchange|activation of respiratory gaseous exchange|upregulation of respiratory gaseous exchange|up regulation of respiratory gaseous exchange sl 2015-02-17T20:26:35Z biological_process owl:Class
GO:0015015 biolink:NamedThing heparan sulfate proteoglycan biosynthetic process, enzymatic modification The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization. got7fsn_ti heparan sulphate proteoglycan biosynthesis, enzymatic modification|heparan sulfate proteoglycan anabolism, enzymatic modification|heparan sulfate proteoglycan formation, enzymatic modification|heparan sulfate proteoglycan synthesis, enzymatic modification|heparin proteoglycan biosynthetic process, enzymatic modification|heparan sulphate proteoglycan biosynthetic process, enzymatic modification biological_process owl:Class
GO:0030201 biolink:NamedThing heparan sulfate proteoglycan metabolic process The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. got7fsn_ti heparin proteoglycan metabolic process|heparan sulphate proteoglycan metabolic process|heparan sulphate proteoglycan metabolism|heparan sulfate proteoglycan metabolism biological_process owl:Class
GO:0003299 biolink:NamedThing muscle hypertrophy in response to stress The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis. got7fsn_ti dph 2009-10-22T09:26:10Z biological_process owl:Class
GO:0009891 biolink:NamedThing positive regulation of biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances. got7fsn_ti positive regulation of biosynthesis|positive regulation of anabolism|upregulation of biosynthetic process|up regulation of biosynthetic process|stimulation of biosynthetic process|activation of biosynthetic process|positive regulation of synthesis|positive regulation of formation|up-regulation of biosynthetic process biological_process owl:Class
GO:0002171 biolink:NamedThing low-affinity IgA receptor activity Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti low affinity IgA receptor activity hjd 2010-05-06T05:01:41Z molecular_function owl:Class
GO:0048721 biolink:NamedThing clypeus morphogenesis The process in which the anatomical structures of the clypeus are generated and organized. got7fsn_ti biological_process owl:Class
GO:0009243 biolink:NamedThing O antigen biosynthetic process The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. got7fsn_ti O antigen formation|O antigen anabolism|O antigen biosynthesis|O antigen synthesis biological_process owl:Class
GO:0071070 biolink:NamedThing alpha4-beta1 integrin-thrombospondin-2 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2. got7fsn_ti ITGA4-ITGB1-THBS2 complex mah 2009-11-03T04:05:56Z cellular_component owl:Class
GO:0043894 biolink:NamedThing acetyl-CoA synthetase acetyltransferase activity Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate. got7fsn_ti Pat|protein acetyltransferase activity|Pat enzyme molecular_function owl:Class
GO:0106050 biolink:NamedThing tRNA 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing a 2'-O-nucleotide. got7fsn_ti hjd 2017-08-11T20:30:31Z molecular_function owl:Class
GO:0047565 biolink:NamedThing 3-hydroxypropionate dehydrogenase (NAD+) activity Catalysis of the reaction: 3-hydroxypropanoate + NAD(+) = 3-oxopropanoate + H(+) + NADH. got7fsn_ti 3-hydroxypropanoate:NAD+ oxidoreductase activity KEGG_REACTION:R01608|EC:1.1.1.59|RHEA:13357|MetaCyc:3-HYDROXYPROPIONATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0050450 biolink:NamedThing citrate (Re)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group. got7fsn_ti citrate oxaloacetate-lyase ((pro-3R)-CH(2)COO(-)->acetyl-CoA) activity|acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]|(R)-citrate synthase activity|Re-citrate-synthase activity|citrate oxaloacetate-lyase [(pro-3R)-CH2COO-rightacetyl-CoA] EC:2.3.3.3|MetaCyc:CITRATE-RE-SYNTHASE-RXN molecular_function owl:Class
GO:0036440 biolink:NamedThing citrate synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA. got7fsn_ti bf 2013-09-30T16:21:50Z KEGG_REACTION:R00351|RHEA:16845 molecular_function owl:Class
GO:1990737 biolink:NamedThing response to manganese-induced endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus. got7fsn_ti response to Mn-induced ER stress|response to manganese-induced ER stress|manganese-induced ER stress response bf 2015-04-30T13:48:45Z biological_process owl:Class
GO:0034976 biolink:NamedThing response to endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. got7fsn_ti cellular response to endoplasmic reticulum stress|ER stress response|response to ER stress biological_process owl:Class
GO:0019679 biolink:NamedThing propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle. got7fsn_ti propionate metabolism, methylcitrate cycle MetaCyc:PWY0-42 biological_process owl:Class
GO:0019541 biolink:NamedThing propionate metabolic process The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants. got7fsn_ti propanoate metabolism|propanoate metabolic process|propionate metabolism biological_process owl:Class
GO:0032280 biolink:NamedThing symmetric synapse A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory. got7fsn_ti Gray's type II synapse The term 'symmetric' in this name refers only to gross morphology. There is no implication of functional symmetry. cellular_component owl:Class
GO:0098984 biolink:NamedThing neuron to neuron synapse A synapse in which pre and post-synaptic cells are neurons. got7fsn_ti cellular_component owl:Class
GO:0050093 biolink:NamedThing methanol dehydrogenase activity Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH. got7fsn_ti methanol:NAD+ oxidoreductase activity RHEA:19401|EC:1.1.1.244|MetaCyc:METHANOL-DEHYDROGENASE-RXN|KEGG_REACTION:R00605 molecular_function owl:Class
GO:0015813 biolink:NamedThing L-glutamate transmembrane transport The directed movement of L-glutamate across a membrane. got7fsn_ti mitochondrial aspartate/glutamate transport|L-glutamate transport GO:0089711 biological_process owl:Class
GO:0050309 biolink:NamedThing sugar-terminal-phosphatase activity Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate. got7fsn_ti sugar-omega-phosphate phosphohydrolase activity|xylitol-5-phosphatase activity EC:3.1.3.58 molecular_function owl:Class
GO:0061080 biolink:NamedThing right horn of sinus venosus development The progression of the right horn of the sinus venosus from its formation to the mature structure. got7fsn_ti dph 2010-04-08T02:45:10Z biological_process owl:Class
GO:0007162 biolink:NamedThing negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. got7fsn_ti down-regulation of cell adhesion|downregulation of cell adhesion|cell adhesion receptor inhibitor activity|down regulation of cell adhesion|inhibition of cell adhesion biological_process owl:Class
GO:0031626 biolink:NamedThing beta-endorphin binding Binding to beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin. got7fsn_ti molecular_function owl:Class
GO:0032837 biolink:NamedThing distributive segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally. got7fsn_ti biological_process owl:Class
GO:0045132 biolink:NamedThing meiotic chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. got7fsn_ti biological_process owl:Class
GO:0070042 biolink:NamedThing rRNA (uridine-N3-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methyluridine. got7fsn_ti molecular_function owl:Class
GO:0016436 biolink:NamedThing rRNA (uridine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine. got7fsn_ti molecular_function owl:Class
GO:0032310 biolink:NamedThing prostaglandin secretion The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue. got7fsn_ti prostacyclin secretion biological_process owl:Class
GO:0031053 biolink:NamedThing primary miRNA processing Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule. got7fsn_ti primary microRNA processing|pri-miRNA processing biological_process owl:Class
GO:0006194 biolink:NamedThing dIDP phosphorylation The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP. got7fsn_ti biological_process owl:Class
GO:0047252 biolink:NamedThing beta-mannosylphosphodecaprenol-mannooligosaccharide 6-mannosyltransferase activity Catalysis of the reaction: (1->6)-alpha-D-mannosyloligosaccharide + beta-D-mannosylphosphodecaprenol = (1->6)-alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-oligosaccharide + decaprenol phosphate. got7fsn_ti beta-D-mannosylphosphodecaprenol:1,6-alpha-D-mannosyloligosaccharide 1,6-alpha-D-mannosyltransferase activity|mannosylphospholipid-methylmannoside alpha-1,6-mannosyltransferase activity EC:2.4.1.199|MetaCyc:2.4.1.199-RXN molecular_function owl:Class
GO:0000030 biolink:NamedThing mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. got7fsn_ti Reactome:R-HSA-162797|Reactome:R-HSA-446198|Reactome:R-HSA-4720497|Reactome:R-HSA-162830 molecular_function owl:Class
GO:0140114 biolink:NamedThing cellular detoxification of fluoride Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14391 pg 2017-10-23T15:39:43Z biological_process owl:Class
GO:0007378 biolink:NamedThing amnioserosa formation Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift. got7fsn_ti biological_process owl:Class
GO:0004556 biolink:NamedThing alpha-amylase activity Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. got7fsn_ti endoamylase activity|1,4-alpha-D-glucan glucanohydrolase activity|taka-amylase A|glycogenase activity|alpha amylase activity MetaCyc:RXN-1825|Reactome:R-HSA-191114|Reactome:R-HSA-188979|EC:3.2.1.1|MetaCyc:ALPHA-AMYL-RXN|MetaCyc:RXN-1823 molecular_function owl:Class
GO:0045330 biolink:NamedThing aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. got7fsn_ti molecular_function owl:Class
GO:0000350 biolink:NamedThing generation of catalytic spliceosome for second transesterification step Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing. got7fsn_ti spliceosomal C2 complex biosynthesis|spliceosomal A2-3 complex formation|formation of spliceosomal C1 complex|formation of catalytic spliceosome for second transesterification step|spliceosomal A2-3 complex biosynthesis|lariat formation, 5'-splice site cleavage|formation of catalytic U12-type spliceosome for second transesterification step|catalytic spliceosome assembly for second transesterification step|spliceosomal C2 complex formation|formation of spliceosomal A2-2 complex|formation of catalytic U2-type spliceosome for second transesterification step Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian). GO:0000359|GO:0000358 biological_process owl:Class
GO:0002394 biolink:NamedThing tolerance induction in gut-associated lymphoid tissue Tolerance induction taking place in the gut-associated lymphoid tissue (GALT). got7fsn_ti oral tolerance|tolerance induction in GALT biological_process owl:Class
GO:0002401 biolink:NamedThing tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT). got7fsn_ti tolerance induction in MALT biological_process owl:Class
GO:0044542 biolink:NamedThing plasminogen activation in other organism The chemical reactions and pathways performed by an organism resulting in the processing of inactive plasminogen to active plasmin in another organism. got7fsn_ti jl 2012-03-22T11:40:03Z biological_process owl:Class
GO:0044541 biolink:NamedThing zymogen activation in other organism The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism. got7fsn_ti jl 2012-03-22T11:39:41Z biological_process owl:Class
GO:0043197 biolink:NamedThing dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. got7fsn_ti sessile dendritic spine|dendrite spine|branched dendritic spine|stubby dendritic spine|mushroom dendritic spine|thin dendritic spine Wikipedia:Dendritic_spine|NIF_Subcellular:sao1799103720 cellular_component owl:Class
GO:0098794 biolink:NamedThing postsynapse The part of a synapse that is part of the post-synaptic cell. got7fsn_ti cellular_component owl:Class
GO:0031996 biolink:NamedThing thioesterase binding Binding to a thioesterase. got7fsn_ti thiolesterase binding molecular_function owl:Class
GO:0070294 biolink:NamedThing renal sodium ion absorption A renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. got7fsn_ti nephron sodium ion absorption|renal sodium ion reabsorption biological_process owl:Class
GO:0004048 biolink:NamedThing anthranilate phosphoribosyltransferase activity Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate. got7fsn_ti anthranilate-PP-ribose-P phosphoribosyltransferase activity|N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity|PRT|phosphoribosylanthranilate transferase activity|phosphoribosyl-anthranilate diphosphorylase activity|phosphoribosylanthranilate pyrophosphorylase activity|anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity|phosphoribosyl-anthranilate pyrophosphorylase activity|anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity RHEA:11768|MetaCyc:PRTRANS-RXN|EC:2.4.2.18|KEGG_REACTION:R01073 molecular_function owl:Class
GO:0050315 biolink:NamedThing synephrine dehydratase activity Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium. got7fsn_ti 1-(4-hydroxyphenyl)-2-(methylamino)ethanol hydro-lyase (methylamine-forming) EC:4.2.1.88|RHEA:32203|KEGG_REACTION:R03359|MetaCyc:SYNEPHRINE-DEHYDRATASE-RXN molecular_function owl:Class
GO:0015481 biolink:NamedThing maltose transporting porin activity Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. got7fsn_ti maltoporin Wikipedia:Maltoporin molecular_function owl:Class
GO:0046916 biolink:NamedThing cellular transition metal ion homeostasis Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. got7fsn_ti biological_process owl:Class
GO:0033605 biolink:NamedThing positive regulation of catecholamine secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine. got7fsn_ti up regulation of catecholamine secretion|activation of catecholamine secretion|upregulation of catecholamine secretion|stimulation of catecholamine secretion|up-regulation of catecholamine secretion biological_process owl:Class
GO:0009714 biolink:NamedThing chalcone metabolic process The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives. got7fsn_ti chalcone metabolism biological_process owl:Class
GO:0009698 biolink:NamedThing phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. got7fsn_ti phenylpropanoid metabolism MetaCyc:PWY1F-467 biological_process owl:Class
GO:0033330 biolink:NamedThing kaempferol O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol. got7fsn_ti kaempferol O-glucoside synthesit|kaempferol O-glucoside anabolism|kaempferol O-glucoside biosynthesis|kaempferol O-glucoside formation MetaCyc:PWY-5320 biological_process owl:Class
GO:0033329 biolink:NamedThing kaempferol O-glucoside metabolic process The chemical reactions and pathways involving O-glucosylated derivatives of kaempferol. got7fsn_ti kaempferol O-glucoside metabolism biological_process owl:Class
GO:0103023 biolink:NamedThing ITPase activity Catalysis of the reaction: ITP + H2O <=> H+ + IDP + hydrogenphosphate. got7fsn_ti MetaCyc:RXN0-5073|RHEA:28330 molecular_function owl:Class
GO:0097004 biolink:NamedThing adipokinetic hormone binding Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. got7fsn_ti AKH binding pr 2011-03-14T12:50:02Z molecular_function owl:Class
GO:0004081 biolink:NamedThing bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate. got7fsn_ti Ap4Aase activity|bis(5'-guanosyl)-tetraphosphatase activity|Ap4A hydrolase activity|diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase|diadenosine P1,P4-tetraphosphatase activity|bis(5'-adenosyl)-tetraphosphatase activity|Ap(4)A hydrolase activity|dinucleosidetetraphosphatase (asymmetrical) activity|diguanosinetetraphosphatase (asymmetrical) activity|diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity|diadenosinetetraphosphatase (asymmetrical) activity|Ap(4)Aase activity|dinucleoside tetraphosphatase activity|diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity|P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity|1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity EC:3.6.1.17|MetaCyc:3.6.1.17-RXN|Reactome:R-HSA-5696197|RHEA:22484 molecular_function owl:Class
GO:0008796 biolink:NamedThing bis(5'-nucleosyl)-tetraphosphatase activity Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides. got7fsn_ti molecular_function owl:Class
GO:0030374 biolink:NamedThing nuclear receptor coactivator activity A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. got7fsn_ti ligand-dependent nuclear receptor transcription coactivator activity|transcription factor activity, ligand-activated RNA polymerase II transcription factor binding|ligand-dependent nuclear receptor transcription co-activator activity|ligand-activated RNA polymerase II transcription factor binding transcription factor activity|nuclear receptor transcription coactivator activity https://github.com/geneontology/go-ontology/issues/20253|https://github.com/geneontology/go-ontology/issues/20464 For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. bf 2011-11-29T01:53:30Z GO:0038049 molecular_function owl:Class
GO:0003713 biolink:NamedThing transcription coactivator activity A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. got7fsn_ti transcription co-activator activity|RNA polymerase II transcription co-activator activity|RNA polymerase II transcription coactivator activity|RNA polymerase II transcription mediator activity|transcription coactivator activity https://github.com/geneontology/go-ontology/issues/15998|https://github.com/geneontology/go-ontology/issues/20464|https://github.com/geneontology/go-ontology/issues/20253|https://github.com/geneontology/go-ontology/issues/15665 For usage guidance, see comment in GO:0003712 ; transcription coregulator activity. krc 2010-11-24T03:08:19Z GO:0001105 molecular_function owl:Class
GO:0106018 biolink:NamedThing phosphatidylinositol-3,5-bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. got7fsn_ti hjd 2017-05-10T14:19:13Z molecular_function owl:Class
GO:0005080 biolink:NamedThing protein kinase C binding Binding to protein kinase C. got7fsn_ti PKC alpha binding|protein kinase C delta binding|PKC eta binding|PKC binding|protein kinase C eta binding|PKC delta binding|protein kinase C alpha binding GO:0072568|GO:0072569|GO:0097024 molecular_function owl:Class
GO:0034447 biolink:NamedThing very-low-density lipoprotein particle clearance The process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. got7fsn_ti VLDL clearance biological_process owl:Class
GO:0047611 biolink:NamedThing acetylspermidine deacetylase activity Catalysis of the reaction: N(8)-acetylspermidine + H(2)O = acetate + spermidine. got7fsn_ti N(1)-acetylspermidine amidohydrolase activity|N8-acetylspermidine deacetylase activity|N-acetylspermidine deacetylase activity|8-N-acetylspermidine amidohydrolase activity|N(8)-monoacetylspermidine deacetylase activity|N8-acetylspermidine amidohydrolase activity|N(8)-acetylspermidine deacetylase activity|N(8)-acetylspermidine amidohydrolase activity|N8-monoacetylspermidine deacetylase activity|N1-acetylspermidine amidohydrolase activity KEGG_REACTION:R07300|RHEA:23928|EC:3.5.1.48|MetaCyc:ACETYLSPERMIDINE-DEACETYLASE-RXN molecular_function owl:Class
GO:0047295 biolink:NamedThing geranylgeranylglycerol-phosphate geranylgeranyltransferase activity Catalysis of the reaction: sn-3-O-(geranylgeranyl)glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = 2,3-di-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate. got7fsn_ti geranylgeranyltransferase II|geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity|geranylgeranyloxyglycerol phosphate geranylgeranyltransferase activity EC:2.5.1.42|MetaCyc:2.5.1.42-RXN|KEGG_REACTION:R04520|RHEA:18109 molecular_function owl:Class
GO:0051444 biolink:NamedThing negative regulation of ubiquitin-protein transferase activity Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. got7fsn_ti ubiquitin transferase inhibitor|anaphase-promoting complex inhibition|anaphase promoting complex inhibition|anaphase-promoting complex inhibitor|negative regulation of ubiquitin transferase activity|anaphase promoting complex inhibitor|APC inhibitor|SCF complex inhibitor|inhibition of ubiquitin transferase activity|down-regulation of ubiquitin transferase activity|down regulation of ubiquitin transferase activity|APC inhibition|downregulation of ubiquitin transferase activity biological_process owl:Class
GO:0031397 biolink:NamedThing negative regulation of protein ubiquitination Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. got7fsn_ti down regulation of protein ubiquitination|down-regulation of protein ubiquitination|inhibition of protein ubiquitination|downregulation of protein ubiquitination biological_process owl:Class
GO:0090162 biolink:NamedThing establishment of epithelial cell polarity The specification and formation of anisotropic intracellular organization of an epithelial cell. got7fsn_ti tb 2009-12-08T08:58:27Z biological_process owl:Class
GO:1905330 biolink:NamedThing regulation of morphogenesis of an epithelium Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium. got7fsn_ti regulation of epithelium morphogenesis An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). bhm 2016-07-22T07:13:49Z biological_process owl:Class
GO:0005140 biolink:NamedThing interleukin-9 receptor binding Binding to an interleukin-9 receptor. got7fsn_ti interleukin-9 receptor ligand|IL-9 molecular_function owl:Class
GO:0032359 biolink:NamedThing provirus excision The molecular events that lead to the excision of a viral genome from the host genome. got7fsn_ti prophage excision biological_process owl:Class
GO:0060218 biolink:NamedThing hematopoietic stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. got7fsn_ti haematopoietic stem cell differentiation|haemopoietic stem cell differentiation|hemopoietic stem cell differentiation biological_process owl:Class
GO:0042284 biolink:NamedThing sphingolipid delta-4 desaturase activity Catalysis of the reaction: a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ -> a sphingosine ceramide (aka (4E)-sphing-4-enine ceramide) + 2 ferricytochrome b5 + 2 H2O. got7fsn_ti delta-4 sphingolipid desaturase activity https://github.com/geneontology/go-ontology/issues/21105 RHEA:46544|EC:1.14.19.17|Reactome:R-HSA-428259 molecular_function owl:Class
GO:0047704 biolink:NamedThing bile-salt sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate. got7fsn_ti 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase activity|bile-salt sulphotransferase activity|bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity|glycolithocholate sulfotransferase activity|bile acid sulfotransferase I activity|bile salt:3'phosphoadenosine-5'-phosphosulfate:sulfotransferase activity|BAST I activity RHEA:14013|EC:2.8.2.14|MetaCyc:BILE-SALT-SULFOTRANSFERASE-RXN molecular_function owl:Class
GO:0042351 biolink:NamedThing 'de novo' GDP-L-fucose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271). got7fsn_ti 'de novo' GDP-L-fucose synthesis|'de novo' GDP-L-fucose biosynthesis|'de novo' GDP-L-fucose anabolism|GDP-L-fucose biosynthetic process, de novo pathway|GDP-L-fucose biosynthesis, de novo pathway|'de novo' GDP-L-fucose formation MetaCyc:PWY-66 biological_process owl:Class
GO:0042350 biolink:NamedThing GDP-L-fucose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate. got7fsn_ti GDP-L-fucose formation|GDP-L-fucose synthesis|GDP-L-fucose anabolism|GDP-L-fucose biosynthesis biological_process owl:Class
GO:0035448 biolink:NamedThing extrinsic component of thylakoid membrane The component of a thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti peripheral to thylakoid membrane|extrinsic to thylakoid membrane bf 2010-04-16T10:11:32Z cellular_component owl:Class
GO:0019898 biolink:NamedThing extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti peripheral membrane protein|extrinsic to membrane Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. GO:0030396 Wikipedia:Peripheral_membrane_protein cellular_component owl:Class
GO:0016606 biolink:NamedThing LYSP100-associated nuclear domain A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies. got7fsn_ti LANDs cellular_component owl:Class
GO:0060427 biolink:NamedThing lung connective tissue development The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs. got7fsn_ti pulmonary connective tissue development biological_process owl:Class
GO:0043117 biolink:NamedThing positive regulation of vascular permeability Any process that increases the extent to which blood vessels can be pervaded by fluid. got7fsn_ti activation of vascular permeability|stimulation of vascular permeability|up-regulation of vascular permeability|up regulation of vascular permeability|upregulation of vascular permeability biological_process owl:Class
GO:0051993 biolink:NamedThing abscisic acid glucose ester beta-glucosidase activity Catalysis of the reaction: abscisic acid glucose ester + H2O = abscisic acid + beta-D-glucose. got7fsn_ti ABA-GE beta-glucosidase activity ai 2010-07-16T02:16:59Z MetaCyc:RXN-11469|EC:3.2.1.175|RHEA:31347 molecular_function owl:Class
GO:0038041 biolink:NamedThing cross-receptor inhibition within G protein-coupled receptor heterodimer Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit. got7fsn_ti cross-receptor inhibition within G-protein coupled receptor heterodimer bf 2011-11-02T04:52:24Z biological_process owl:Class
GO:2000272 biolink:NamedThing negative regulation of signaling receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity. got7fsn_ti negative regulation of receptor activity|negative regulation of signalling receptor activity bf 2010-12-02T09:28:47Z biological_process owl:Class
GO:0005963 biolink:NamedThing magnesium-dependent protein serine/threonine phosphatase complex An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase. got7fsn_ti cellular_component owl:Class
GO:0008474 biolink:NamedThing palmitoyl-(protein) hydrolase activity Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. got7fsn_ti palmitoyl-[protein] hydrolase|palmitoyl-protein thiolesterase activity|palmitoyl-protein hydrolase activity|palmitoyl-protein thioesterase activity Reactome:R-HSA-8933328|Reactome:R-HSA-203613|EC:3.1.2.22|Reactome:R-HSA-9647994|Reactome:R-HSA-5690517|RHEA:19233|MetaCyc:3.1.2.22-RXN molecular_function owl:Class
GO:0098599 biolink:NamedThing palmitoyl hydrolase activity Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate. got7fsn_ti dos 2014-04-11T17:57:36Z Reactome:R-HSA-9027670|Reactome:R-HSA-5690046 molecular_function owl:Class
GO:0008989 biolink:NamedThing rRNA (guanine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine. got7fsn_ti S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity|ribosomal ribonucleate guanine 1-methyltransferase activity|S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0018741 biolink:NamedThing alkyl sulfatase activity Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol. got7fsn_ti alkyl sulphatase activity UM-BBD_reactionID:r0602|EC:3.1.6.- molecular_function owl:Class
GO:0043470 biolink:NamedThing regulation of carbohydrate catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates. got7fsn_ti biological_process owl:Class
GO:0009894 biolink:NamedThing regulation of catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances. got7fsn_ti regulation of degradation|regulation of breakdown|regulation of catabolism biological_process owl:Class
GO:0044158 biolink:NamedThing host cell wall The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. got7fsn_ti jl 2009-08-11T04:09:23Z cellular_component owl:Class
GO:0010049 biolink:NamedThing acquisition of plant reproductive competence The process in which a plant acquires the ability to respond to a floral inductive signal. got7fsn_ti acquisition of reproductive competence biological_process owl:Class
GO:0043013 biolink:NamedThing negative regulation of fusion of sperm to egg plasma membrane Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane. got7fsn_ti inhibition of fusion of sperm to egg plasma membrane|negative regulation of sperm-oocyte fusion|downregulation of fusion of sperm to egg plasma membrane|inhibition of sperm-oocyte fusion|down regulation of fusion of sperm to egg plasma membrane|down-regulation of fusion of sperm to egg plasma membrane biological_process owl:Class
GO:0047301 biolink:NamedThing valine-3-methyl-2-oxovalerate transaminase activity Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + L-valine = 3-methyl-2-oxobutanoate + L-isoleucine. got7fsn_ti valine--3-methyl-2-oxovalerate aminotransferase activity|valine-2-keto-methylvalerate aminotransferase activity|valine-3-methyl-2-oxovalerate aminotransferase activity|valine--isoleucine aminotransferase activity|valine--isoleucine transaminase activity|L-valine:(S)-3-methyl-2-oxopentanoate aminotransferase activity RHEA:11468|MetaCyc:2.6.1.32-RXN|EC:2.6.1.32|KEGG_REACTION:R02200 molecular_function owl:Class
GO:1990356 biolink:NamedThing sumoylated E2 ligase complex A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase. got7fsn_ti An example of this is UBC9 in human (UniProt symbol P63279) in PMID:18691969 (inferred from direct assay). bhm 2014-04-02T14:06:56Z cellular_component owl:Class
GO:0050091 biolink:NamedThing melilotate 3-monooxygenase activity Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+). got7fsn_ti melilotic hydroxylase activity|2-hydroxyphenylpropionic hydroxylase activity|2-hydroxyphenylpropionate hydroxylase activity|melilotate hydroxylase activity|3-(2-hydroxyphenyl)propanoate,NADH:oxygen oxidoreductase (3-hydroxylating) EC:1.14.13.4|KEGG_REACTION:R03369|MetaCyc:MELILOTATE-3-MONOOXYGENASE-RXN|RHEA:17669 molecular_function owl:Class
GO:0050082 biolink:NamedThing maltose phosphorylase activity Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate. got7fsn_ti maltose:phosphate 1-beta-D-glucosyltransferase activity MetaCyc:MALTOSE-PHOSPHORYLASE-RXN|RHEA:21116|EC:2.4.1.8 molecular_function owl:Class
GO:0016263 biolink:NamedThing glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan. got7fsn_ti Core 1 GalT|UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity|UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity|uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity RHEA:15621|Reactome:R-HSA-6785524|EC:2.4.1.122|Reactome:R-HSA-1964505|MetaCyc:2.4.1.122-RXN molecular_function owl:Class
GO:0008403 biolink:NamedThing 25-hydroxycholecalciferol-24-hydroxylase activity Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol. got7fsn_ti cytochrome P450 CYP24|25-hydroxyvitamin D3 24-hydroxylase activity GO:0030344 molecular_function owl:Class
GO:0032390 biolink:NamedThing MutLbeta complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1. got7fsn_ti MLH1/PMS1 complex|MMR complex cellular_component owl:Class
GO:0110070 biolink:NamedThing cellularization cleavage furrow A plasma membrane invagination at the site of separation of a multi-nucleate cell or syncytium into individual cells. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14543|https://github.com/geneontology/go-ontology/issues/21737 kmv 2017-11-22T20:10:14Z cellular_component owl:Class
GO:0098590 biolink:NamedThing plasma membrane region A membrane that is a (regional) part of the plasma membrane. got7fsn_ti region of plasma membrane Note that this term should not be used for direct manual annotation as it should always be possible to choose a more specific subclass. dos 2014-03-06T11:55:32Z cellular_component owl:Class
GO:0042093 biolink:NamedThing T-helper cell differentiation The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell. got7fsn_ti T-helper cell development|helper T cell differentiation biological_process owl:Class
GO:0002294 biolink:NamedThing CD4-positive, alpha-beta T cell differentiation involved in immune response The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. got7fsn_ti CD4-positive, alpha-beta T cell differentiation during immune response|CD4-positive, alpha-beta T-cell differentiation during immune response|CD4-positive, alpha-beta T-lymphocyte differentiation during immune response|CD4-positive, alpha-beta T lymphocyte differentiation during immune response|CD4-positive, alpha-beta T cell development involved in immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0070317 biolink:NamedThing negative regulation of G0 to G1 transition A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase. got7fsn_ti maintenance of G0 phase|maintenance of cell cycle quiescence|maintenance of cell quiescence|maintenance of G0 arrest biological_process owl:Class
GO:0032983 biolink:NamedThing kainate selective glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits. got7fsn_ti cellular_component owl:Class
GO:0004080 biolink:NamedThing biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)). got7fsn_ti propionyl coenzyme A holocarboxylase synthetase activity|biotin-propionyl coenzyme A carboxylase synthetase activity|holocarboxylase synthetase activity|biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity|biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)|propionyl-CoA holocarboxylase synthetase activity|biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity MetaCyc:6.3.4.10-RXN|RHEA:11204|EC:6.3.4.10 molecular_function owl:Class
GO:0031639 biolink:NamedThing plasminogen activation The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide. got7fsn_ti cleavage of plasminogen to plasmin biological_process owl:Class
GO:0015043 biolink:NamedThing leghemoglobin reductase activity Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin. got7fsn_ti ferric leghemoglobin reductase activity|NAD(P)H:ferrileghemoglobin oxidoreductase activity MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN|EC:1.6.2.6 molecular_function owl:Class
GO:0016653 biolink:NamedThing oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. got7fsn_ti oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor|oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor EC:1.6.2.- molecular_function owl:Class
GO:0031074 biolink:NamedThing nucleocytoplasmic transport complex Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores. got7fsn_ti nucleocytoplasmic shuttling complex cellular_component owl:Class
GO:0042100 biolink:NamedThing B cell proliferation The expansion of a B cell population by cell division. Follows B cell activation. got7fsn_ti B-lymphocyte proliferation|B-cell proliferation|B lymphocyte proliferation GO:0042114 biological_process owl:Class
GO:0097480 biolink:NamedThing establishment of synaptic vesicle localization The directed movement of a synaptic vesicle or vesicles to a specific location. got7fsn_ti establishment of synaptic vesicle localisation pr 2013-05-22T14:32:12Z biological_process owl:Class
GO:0005903 biolink:NamedThing brush border The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. got7fsn_ti Wikipedia:Brush_border cellular_component owl:Class
GO:0048275 biolink:NamedThing N-terminal peptidyl-arginine acetylation The acetylation of the N-terminal arginine of proteins; catalyzed by an uncharacterized arginyl-peptide alpha-N-acetyltransferase. got7fsn_ti RESID:AA0354 biological_process owl:Class
GO:0040004 biolink:NamedThing collagen and cuticulin-based cuticle attachment to epithelium Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans. got7fsn_ti cuticular attachment to epithelium biological_process owl:Class
GO:0102640 biolink:NamedThing paspalinine synthase activity Catalysis of the reaction: paspalicine + O2 + NADPH + H+ <=> paspalinine + NADP + H2O. got7fsn_ti MetaCyc:RXN-15738 molecular_function owl:Class
GO:0033314 biolink:NamedThing mitotic DNA replication checkpoint signaling A signal transduction process that contributes to a mitotic DNA replication checkpoint. got7fsn_ti S-M checkpoint|mitotic DNA replication checkpoint|signal transduction involved in mitotic G2/M transition decatenation checkpoint|S-phase checkpoint|mitotic cell cycle DNA replication checkpoint|signal transduction involved in mitotic DNA replication checkpoint|signal transduction involved in S-M checkpoint|S-M DNA replication checkpoint GO:0072459|GO:0072446|GO:0031574|GO:0072443 biological_process owl:Class
GO:0000076 biolink:NamedThing DNA replication checkpoint signaling A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. got7fsn_ti signal transduction involved in DNA replication checkpoint|DNA replication checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072437 biological_process owl:Class
GO:0050145 biolink:NamedThing nucleoside monophosphate kinase activity Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. got7fsn_ti nucleotide kinase activity|nucleoside-phosphate kinase activity|ATP:nucleoside-phosphate phosphotransferase activity|nucleoside monophosphate kinase activity|NMP-kinase activity GO:0019201 Reactome:R-HSA-73548|Reactome:R-HSA-73635|Reactome:R-HSA-6788798|EC:2.7.4.4|Reactome:R-HSA-75125|MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN|Reactome:R-HSA-75126|Reactome:R-HSA-2162092|Reactome:R-HSA-6788810|RHEA:24036 molecular_function owl:Class
GO:0052023 biolink:NamedThing modulation by symbiont of salicylic acid levels in host The alteration by an organism of the levels of salicylic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of salicylic acid levels in other organism involved in symbiotic interaction GO:0052469 biological_process owl:Class
GO:0052019 biolink:NamedThing modulation by symbiont of host hormone or growth regulator levels The alteration by an organism of the levels of hormones or growth regulators in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of hormone or growth regulator levels in other organism involved in symbiotic interaction GO:0052186 biological_process owl:Class
GO:0061806 biolink:NamedThing regulation of DNA recombination at centromere Any process that modulates the frequency, rate or extent of DNA recombination within centromeric DNA. got7fsn_ti regulation of centromeric recombination dph 2016-11-10T15:17:11Z biological_process owl:Class
GO:0000018 biolink:NamedThing regulation of DNA recombination Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. got7fsn_ti biological_process owl:Class
GO:0015471 biolink:NamedThing nucleoside-specific channel forming porin activity Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. got7fsn_ti molecular_function owl:Class
GO:0060121 biolink:NamedThing vestibular receptor cell stereocilium organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of vestibular hair cells. got7fsn_ti vestibular hair cell stereocilium organization|vestibular receptor cell stereocilium organization and biogenesis|vestibular receptor cell stereocilium organisation biological_process owl:Class
GO:0050616 biolink:NamedThing secologanin synthase activity Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O. got7fsn_ti loganin:oxygen oxidoreductase (ring-cleaving) EC:1.14.19.62|RHEA:20585|MetaCyc:1.3.3.9-RXN molecular_function owl:Class
GO:0047451 biolink:NamedThing 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxyoctanoyl-[acyl-carrier protein] = H2O + 2-octenoyl-[acyl-carrier protein]. got7fsn_ti 3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity|3-hydroxyoctanoyl-ACP dehydratase activity|D-3-hydroxyoctanoyl-[acyl carrier protein] dehydratase activity|(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase activity|3-hydroxyoctanoyl-[acyl-carrier protein] dehydratase activity|D-3-hydroxyoctanoyl-acyl carrier protein dehydratase activity|beta-hydroxyoctanoyl-acyl carrier protein dehydrase activity|beta-hydroxyoctanoyl-ACP-dehydrase activity|beta-hydroxyoctanoyl thioester dehydratase activity|(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] hydro-lyase activity|(3R)-3-hydroxyoctanoyl-acyl-carrier-protein hydro-lyase (oct-2-enoyl-acyl-carrier protein-forming) RHEA:41844|MetaCyc:4.2.1.59-RXN|EC:4.2.1.59|KEGG_REACTION:R04537 molecular_function owl:Class
GO:1903793 biolink:NamedThing positive regulation of anion transport Any process that activates or increases the frequency, rate or extent of anion transport. got7fsn_ti up regulation of anion transport|upregulation of anion transport|activation of anion transport|up-regulation of anion transport sl 2015-01-12T21:50:30Z biological_process owl:Class
GO:0043270 biolink:NamedThing positive regulation of ion transport Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti stimulation of ion transport|upregulation of ion transport|up regulation of ion transport|activation of ion transport|up-regulation of ion transport biological_process owl:Class
GO:0004602 biolink:NamedThing glutathione peroxidase activity Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. got7fsn_ti GSH peroxidase activity|glutathione:hydrogen-peroxide oxidoreductase activity|reduced glutathione peroxidase activity|non-selenium glutathione peroxidase activity|selenium-glutathione peroxidase activity GO:0016224 Reactome:R-HSA-3341277|Reactome:R-HSA-2161959|Reactome:R-HSA-3343700|Reactome:R-HSA-2161946|Reactome:R-HSA-6799695|Reactome:R-HSA-3341397|Reactome:R-HSA-2161999|Reactome:R-HSA-3323013|MetaCyc:GLUTATHIONE-PEROXIDASE-RXN|EC:1.11.1.9|RHEA:16833|Reactome:R-HSA-2161791|Reactome:R-HSA-71676 molecular_function owl:Class
GO:0002204 biolink:NamedThing somatic recombination of immunoglobulin genes involved in immune response The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response. got7fsn_ti somatic recombination of immunoglobulin genes during immune response|somatic recombination of antibody genes during immune response biological_process owl:Class
GO:0032177 biolink:NamedThing cellular bud neck split septin rings Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated. got7fsn_ti cellular_component owl:Class
GO:0071360 biolink:NamedThing cellular response to exogenous dsRNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus. got7fsn_ti cellular response to exogenous double-stranded RNA|cellular response to viral dsRNA mah 2009-12-11T03:02:00Z biological_process owl:Class
GO:0008120 biolink:NamedThing ceramide glucosyltransferase activity Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. got7fsn_ti glucosylceramide synthase activity|uridine diphosphoglucose-ceramide glucosyltransferase activity|ceramide:UDP-glucose glucosyltransferase activity|UDP-glucose:N-acylsphingosine D-glucosyltransferase activity|UDP-glucose-ceramide glucosyltransferase activity|UDP-glucose:ceramide glucosyltransferase activity|ceramide:UDPGlc glucosyltransferase activity|UDPglucose:N-acylsphingosine D-glucosyltransferase activity MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN|RHEA:12088|Reactome:R-HSA-1638104|EC:2.4.1.80 molecular_function owl:Class
GO:0035470 biolink:NamedThing positive regulation of vascular wound healing Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. got7fsn_ti bf 2010-04-22T10:49:09Z biological_process owl:Class
GO:0090303 biolink:NamedThing positive regulation of wound healing Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. got7fsn_ti tb 2010-03-22T02:12:03Z biological_process owl:Class
GO:0051619 biolink:NamedThing inhibition of histamine uptake Any process that prevents the activation of the directed movement of histamine into a cell. got7fsn_ti inhibition of histamine import biological_process owl:Class
GO:0018290 biolink:NamedThing iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase. got7fsn_ti iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide RESID:AA0141 biological_process owl:Class
GO:0018291 biolink:NamedThing molybdenum incorporation into iron-sulfur cluster The incorporation of molybdenum into an iron-sulfur cluster. got7fsn_ti molybdenum incorporation into iron-sulphur cluster biological_process owl:Class
GO:0017162 biolink:NamedThing aryl hydrocarbon receptor binding Binding to an aryl hydrocarbon receptor. got7fsn_ti molecular_function owl:Class
GO:0000346 biolink:NamedThing transcription export complex The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. got7fsn_ti TREX complex cellular_component owl:Class
GO:0061730 biolink:NamedThing C-rich strand telomeric DNA binding Binding to C-rich, single-stranded, telomere-associated DNA. got7fsn_ti dph 2015-08-20T09:08:27Z molecular_function owl:Class
GO:0051816 biolink:NamedThing acquisition of nutrients from other organism during symbiotic interaction The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0045456 biolink:NamedThing ecdysteroid biosynthetic process The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. got7fsn_ti ecdysteroid formation|ecdysteroid anabolism|ecdysteroid synthesis|ecdysteroid biosynthesis biological_process owl:Class
GO:0090021 biolink:NamedThing positive regulation of posterior neural plate formation by Wnt signaling pathway The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation. got7fsn_ti positive regulation of posterior neural plate formation by Wnt receptor signalling pathway|positive regulation of posterior neural plate formation by Wnt receptor signaling pathway|positive regulation of posterior neural plate formation by Wnt-activated signaling pathway tb 2009-07-29T11:44:13Z biological_process owl:Class
GO:0090058 biolink:NamedThing metaxylem development The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed. got7fsn_ti tb 2009-08-11T03:05:15Z biological_process owl:Class
GO:0051655 biolink:NamedThing maintenance of vesicle location Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of vesicle localization biological_process owl:Class
GO:0016642 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group. got7fsn_ti oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor EC:1.4.4.- molecular_function owl:Class
GO:0034872 biolink:NamedThing trans-geranyl-CoA isomerase activity Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA. got7fsn_ti UM-BBD_reactionID:r1310|EC:5.2.1.- molecular_function owl:Class
GO:0046269 biolink:NamedThing toluene-4-sulfonate catabolic process The chemical reactions and pathways resulting in the breakdown of toluene-4-sulfonate, 4-methylbenzenesulfonate, the anion of sulfonic acid attached to a methylbenzene molecule. got7fsn_ti toluene-4-sulfonate catabolism|toluene-4-sulfonate breakdown|toluene-4-sulphonate catabolism|4-toluenesulfonate catabolism|4-toluenesulfonate catabolic process|toluene-4-sulfonate degradation|toluene-4-sulphonate catabolic process biological_process owl:Class
GO:0032201 biolink:NamedThing telomere maintenance via semi-conservative replication The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication. got7fsn_ti equal telomere replication|telomeric replication fork progression|telomeric fork progression biological_process owl:Class
GO:0000723 biolink:NamedThing telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. got7fsn_ti regulation of telomere length biological_process owl:Class
GO:0060575 biolink:NamedThing intestinal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine. got7fsn_ti dph 2009-05-06T08:17:56Z biological_process owl:Class
GO:1903776 biolink:NamedThing regulation of double-strand break repair via single-strand annealing, removal of nonhomologous ends Any process that modulates the frequency, rate or extent of double-strand break repair via single-strand annealing, removal of nonhomologous ends. got7fsn_ti al 2015-01-06T17:08:24Z biological_process owl:Class
GO:0051052 biolink:NamedThing regulation of DNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. got7fsn_ti regulation of DNA metabolism biological_process owl:Class
GO:0061260 biolink:NamedThing mesonephric mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the mesonephros as it progresses from its formation to the mature state. got7fsn_ti dph 2010-08-30T02:25:08Z biological_process owl:Class
GO:0072007 biolink:NamedThing mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesangial cells of the kidney as it progresses from its formation to the mature state. got7fsn_ti mah 2010-01-25T01:59:09Z biological_process owl:Class
GO:0042003 biolink:NamedThing masculinization of hermaphrodite soma Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans. got7fsn_ti biological_process owl:Class
GO:0042001 biolink:NamedThing hermaphrodite somatic sex determination The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans. got7fsn_ti GO:0042002 biological_process owl:Class
GO:0071017 biolink:NamedThing U12-type catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the U11 and U4atac snRNPs from the precatalytic spliceosome; the U12, U5 and U6atac snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U12, and U5 and U6atac snRNPs. got7fsn_ti minor catalytic step 1 spliceosome|mammalian U12-type spliceosomal complex B*|AT-AC catalytic step 1 spliceosome|yeast U12-type spliceosomal complex A1|U12-type activated spliceosome|mammalian U12-type spliceosomal complex B2 mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0071012 biolink:NamedThing catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs. got7fsn_ti mammalian spliceosomal complex B2|activated spliceosome|mammalian spliceosomal complex B*|yeast spliceosomal complex A1 mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0018072 biolink:NamedThing peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit. got7fsn_ti peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid|peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid|peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid RESID:AA0170 biological_process owl:Class
GO:0042328 biolink:NamedThing heparan sulfate N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate. got7fsn_ti heparan sulphate N-acetylglucosaminyltransferase activity|heparin N-acetylglucosaminyltransferase activity molecular_function owl:Class
GO:0010144 biolink:NamedThing pyridoxal phosphate biosynthetic process from pyridoxamine The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine. got7fsn_ti vitamin B6 biosynthesis from pyridoxamine|pyridoxal 5'-phosphate salvage from pyridoxamine|pyridoxal phosphate anabolism from pyridoxamine|pyridoxal phosphate synthesis from pyridoxamine|vitamin B6 biosynthetic process from pyridoxamine|pyridoxal phosphate formation from pyridoxamine biological_process owl:Class
GO:0009443 biolink:NamedThing pyridoxal 5'-phosphate salvage Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis. got7fsn_ti pyridoxal 5' phosphate salvage MetaCyc:PLPSAL-PWY biological_process owl:Class
GO:0000940 biolink:NamedThing outer kinetochore The region of a kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions. got7fsn_ti condensed chromosome outer kinetochore|outer kinetochore of condensed chromosome|condensed nuclear chromosome outer kinetochore|outer kinetochore plate|outer kinetochore of condensed nuclear chromosome https://github.com/geneontology/go-ontology/issues/21126 GO:0000942 cellular_component owl:Class
GO:0004618 biolink:NamedThing phosphoglycerate kinase activity Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+). got7fsn_ti phosphoglyceric acid kinase activity|glycerophosphate kinase activity|3-PGK|3-phosphoglyceric kinase activity|phosphoglyceric kinase activity|3-phosphoglycerate kinase activity|ATP:3-phospho-D-glycerate 1-phosphotransferase activity|phosphoglycerokinase activity|3-phosphoglyceric acid phosphokinase activity|3-phosphoglyceric acid kinase activity|ATP:D-3-phosphoglycerate 1-phosphotransferase activity|3-phosphoglycerate phosphokinase activity|ATP-3-phospho-D-glycerate-1-phosphotransferase activity|glycerate 3-phosphate kinase activity|PGK KEGG_REACTION:R01512|MetaCyc:PHOSGLYPHOS-RXN|EC:2.7.2.3|RHEA:14801|Reactome:R-HSA-70486|Reactome:R-HSA-71850 molecular_function owl:Class
GO:0060496 biolink:NamedThing mesenchymal-epithelial cell signaling involved in lung development Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell and contributes to the development of the lung. got7fsn_ti mesenchymal-epithelial cell signalling involved in lung development biological_process owl:Class
GO:0022401 biolink:NamedThing negative adaptation of signaling pathway The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus. got7fsn_ti negative adaptation of signal transduction pathway|negative adaptation of signalling pathway biological_process owl:Class
GO:0015985 biolink:NamedThing energy coupled proton transport, down electrochemical gradient The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP. got7fsn_ti biological_process owl:Class
GO:0070050 biolink:NamedThing neuron cellular homeostasis The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. got7fsn_ti neuron maintenance biological_process owl:Class
GO:0051022 biolink:NamedThing Rho GDP-dissociation inhibitor binding Binding to a Rho GDP-dissociation inhibitor protein. got7fsn_ti Rho GDI binding molecular_function owl:Class
GO:0051021 biolink:NamedThing GDP-dissociation inhibitor binding Binding to a GDP-dissociation inhibitor protein. got7fsn_ti GDI binding molecular_function owl:Class
GO:0031900 biolink:NamedThing chromoplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope. got7fsn_ti cellular_component owl:Class
GO:0009527 biolink:NamedThing plastid outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope. got7fsn_ti cellular_component owl:Class
GO:0075606 biolink:NamedThing transport of viral material towards nucleus The directed movement of a virus, or part of a virus, towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane. got7fsn_ti viral genome transport to host cell nucleus|transport of viral material to nucleus|cytoplasmic inwards viral transport This process does not include the viral material crossing the nuclear membrane. For transport of viral material into the nucleus, consider instead: 'viral penetration into host nucleus ; GO:0075732'. jl 2009-11-05T03:33:36Z VZ:990 biological_process owl:Class
GO:0010920 biolink:NamedThing negative regulation of inositol phosphate biosynthetic process Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. got7fsn_ti negative regulation of inositol phosphate biosynthesis biological_process owl:Class
GO:0001873 biolink:NamedThing polysaccharide immune receptor activity Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. got7fsn_ti polysaccharide receptor activity molecular_function owl:Class
GO:0045745 biolink:NamedThing positive regulation of G protein-coupled receptor signaling pathway Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity. got7fsn_ti positive regulation of G protein coupled receptor protein signaling pathway|positive regulation of G-protein-coupled receptor protein signalling pathway|positive regulation of G-protein-coupled receptor protein signaling pathway|upregulation of G-protein coupled receptor protein signaling pathway|up-regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|positive regulation of GPCR protein signalling pathway|positive regulation of G protein coupled receptor protein signalling pathway|up regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signalling pathway|activation of G-protein coupled receptor protein signaling pathway|stimulation of G-protein coupled receptor protein signaling pathway|positive regulation of GPCR protein signaling pathway biological_process owl:Class
GO:0032332 biolink:NamedThing positive regulation of chondrocyte differentiation Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation. got7fsn_ti upregulation of chondrocyte differentiation|stimulation of chondrocyte differentiation|activation of chondrocyte differentiation|up regulation of chondrocyte differentiation|up-regulation of chondrocyte differentiation biological_process owl:Class
GO:0061036 biolink:NamedThing positive regulation of cartilage development Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. got7fsn_ti dph 2010-02-09T03:41:35Z biological_process owl:Class
GO:0050539 biolink:NamedThing maleimide hydrolase activity Catalysis of the reaction: H(2)O + maleimide = H(+) + maleamate. got7fsn_ti imidase activity|cyclic imide hydrolase activity|cyclic-imide amidohydrolase (decyclicizing)|cyclic-imide amidohydrolase (decyclizing) KEGG_REACTION:R05781|MetaCyc:3.5.2.16-RXN|EC:3.5.2.16|RHEA:24476 molecular_function owl:Class
GO:0102739 biolink:NamedThing (gibberellin-36), 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A36 + O2 + 2-oxoglutarate <=> H+ + gibberellin A4 + succinate + 2 carbon dioxide. got7fsn_ti MetaCyc:RXN-7591 molecular_function owl:Class
GO:0016236 biolink:NamedThing macroautophagy The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded. got7fsn_ti autophagy Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities. GO:0034262 biological_process owl:Class
GO:0042084 biolink:NamedThing 5-methyltetrahydrofolate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate. got7fsn_ti molecular_function owl:Class
GO:0000478 biolink:NamedThing endonucleolytic cleavage involved in rRNA processing Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA. got7fsn_ti endonucleolytic cleavage during rRNA processing biological_process owl:Class
GO:0001519 biolink:NamedThing peptide amidation The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions. got7fsn_ti biological_process owl:Class
GO:0031179 biolink:NamedThing peptide modification The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide. got7fsn_ti biological_process owl:Class
GO:0048624 biolink:NamedThing plantlet formation on parent plant The process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed. got7fsn_ti vegetative vivipary|vivipary biological_process owl:Class
GO:0061322 biolink:NamedThing disseminated nephrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a disseminated nephrocyte. A disseminated nephrocyte is an insect renal cell that filters hemolymph and is found at scattered locations in the fat body or other tissues. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. got7fsn_ti dph 2010-09-24T12:30:46Z biological_process owl:Class
GO:0061319 biolink:NamedThing nephrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a nephrocyte. A nephrocyte is an insect renal cell that filters hemolymph. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. got7fsn_ti dph 2010-09-24T12:23:29Z biological_process owl:Class
GO:0061583 biolink:NamedThing colon epithelial cell chemotaxis The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti dph 2013-12-23T07:46:57Z biological_process owl:Class
GO:0080019 biolink:NamedThing fatty-acyl-CoA reductase (alcohol-forming) activity Catalysis of the reaction: a very long chain fatty acyl-CoA + NADPH + H+ = a very long chain primary alcohol + NADP+ + CoA. got7fsn_ti fatty acyl CoA reductase (alcohol-forming) activity|fatty acyl-CoA reductase (alcohol-forming) activity molecular_function owl:Class
GO:0102594 biolink:NamedThing cyanidin 7-O-glucoside acyltransferase(acyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3,7-di-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose. got7fsn_ti MetaCyc:RXN-15372 molecular_function owl:Class
GO:0034007 biolink:NamedThing S-linalool synthase activity Catalysis of the reaction: geranyl diphosphate + H(2)O = (S)-linalool + diphosphate. got7fsn_ti 3S-linalool synthase activity|geranyl-diphosphate diphosphate-lyase [(3S)-linalool-forming] activity|LIS MetaCyc:4.2.3.25-RXN|RHEA:24116|EC:4.2.3.25|KEGG_REACTION:R07631 molecular_function owl:Class
GO:0080045 biolink:NamedThing quercetin 3'-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3'-hydroxy group of a quercetin molecule. got7fsn_ti molecular_function owl:Class
GO:0002308 biolink:NamedThing CD8-positive, alpha-beta cytotoxic T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell. got7fsn_ti CD8-positive, alpha-beta cytotoxic T cell development|CD8-positive, alpha-beta cytotoxic T-cell differentiation|CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation|CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0045065 biolink:NamedThing cytotoxic T cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell. got7fsn_ti cytotoxic T cell development|cytotoxic T-cell selection|cytotoxic T lymphocyte selection|cytotoxic T-lymphocyte selection Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0042171 biolink:NamedThing lysophosphatidic acid acyltransferase activity Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid. got7fsn_ti LPAAT activity molecular_function owl:Class
GO:0060654 biolink:NamedThing mammary gland cord elongation The process in which the mammary gland sprout grows along its axis. got7fsn_ti dph 2009-05-29T09:26:15Z biological_process owl:Class
GO:0060751 biolink:NamedThing branch elongation involved in mammary gland duct branching The developmental growth process in which a branch of a mammary gland duct elongates. got7fsn_ti mammary gland duct branch elongation dph 2009-06-22T11:02:44Z biological_process owl:Class
GO:0050204 biolink:NamedThing oxalomalate lyase activity Catalysis of the reaction: 3-oxalomalate = glyoxylate + oxaloacetate. got7fsn_ti 3-oxalomalate glyoxylate-lyase activity|3-oxalomalate glyoxylate-lyase (oxaloacetate-forming) RHEA:22032|KEGG_REACTION:R00477|EC:4.1.3.13|MetaCyc:OXALOMALATE-LYASE-RXN molecular_function owl:Class
GO:0007548 biolink:NamedThing sex differentiation The establishment of the sex of an organism by physical differentiation. got7fsn_ti Wikipedia:Sexual_differentiation biological_process owl:Class
GO:0032466 biolink:NamedThing negative regulation of cytokinesis Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. got7fsn_ti negative regulation of cell cycle cytokinesis|downregulation of cytokinesis|down-regulation of cytokinesis|inhibition of cytokinesis|down regulation of cytokinesis GO:0071776 biological_process owl:Class
GO:0000471 biolink:NamedThing endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events. got7fsn_ti biological_process owl:Class
GO:0061765 biolink:NamedThing modulation by virus of host NIK/NF-kappaB signaling Any process in which a virus effect a change in the frequency, rate or extent of NIK/NF-kappaB signaling in the host. got7fsn_ti dph 2016-04-19T10:41:22Z biological_process owl:Class
GO:0021583 biolink:NamedThing pons morphogenesis The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. got7fsn_ti biological_process owl:Class
GO:0006269 biolink:NamedThing DNA replication, synthesis of RNA primer The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. got7fsn_ti replication priming biological_process owl:Class
GO:0032774 biolink:NamedThing RNA biosynthetic process The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. got7fsn_ti RNA biosynthesis|RNA formation|RNA synthesis|RNA anabolism Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. biological_process owl:Class
GO:0009090 biolink:NamedThing homoserine biosynthetic process The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid. got7fsn_ti homoserine biosynthesis|homoserine anabolism|homoserine synthesis|homoserine formation MetaCyc:HOMOSERSYN-PWY biological_process owl:Class
GO:0046725 biolink:NamedThing negative regulation by virus of viral protein levels in host cell Any process where the infecting virus reduces the levels of viral proteins in a cell. got7fsn_ti inhibition of viral protein levels in host cell|downregulation of viral protein levels in host cell|down regulation of viral protein levels in host cell|down-regulation of viral protein levels in host cell|negative regulation of viral protein levels biological_process owl:Class
GO:0034858 biolink:NamedThing 2-hydroxybenzothiazole monooxygenase activity Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole. got7fsn_ti UM-BBD_reactionID:r1291 molecular_function owl:Class
GO:0046093 biolink:NamedThing deoxycytidine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA. got7fsn_ti deoxycytidine synthesis|deoxycytidine anabolism|deoxycytidine formation|deoxycytidine biosynthesis biological_process owl:Class
GO:0045932 biolink:NamedThing negative regulation of muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction. got7fsn_ti inhibition of muscle contraction|downregulation of muscle contraction|down regulation of muscle contraction|down-regulation of muscle contraction biological_process owl:Class
GO:0002291 biolink:NamedThing T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response. got7fsn_ti T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell biological_process owl:Class
GO:0010931 biolink:NamedThing macrophage tolerance induction A process involving any mechanism for tolerance induction in macrophages. got7fsn_ti biological_process owl:Class
GO:0071710 biolink:NamedThing membrane macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a membrane in a cell. got7fsn_ti membrane macromolecule anabolism|membrane macromolecule biosynthesis|membrane macromolecule synthesis|membrane macromolecule formation mah 2010-03-10T11:29:52Z biological_process owl:Class
GO:0070589 biolink:NamedThing cellular component macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule that is destined to form part of a specific cellular component. got7fsn_ti cellular component macromolecule biosynthesis mah 2009-04-28T11:01:25Z biological_process owl:Class
GO:0034433 biolink:NamedThing steroid esterification A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol). got7fsn_ti biological_process owl:Class
GO:0102761 biolink:NamedThing eriodictyol 3'-O-methyltransferase activity Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + homoeriodictyol + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-7753|RHEA:60948 molecular_function owl:Class
GO:0001707 biolink:NamedThing mesoderm formation The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts. got7fsn_ti biological_process owl:Class
GO:0001704 biolink:NamedThing formation of primary germ layer The formation of the ectoderm, mesoderm and endoderm during gastrulation. got7fsn_ti biological_process owl:Class
GO:0000451 biolink:NamedThing rRNA 2'-O-methylation The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis. got7fsn_ti biological_process owl:Class
GO:0031167 biolink:NamedThing rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0031177 biolink:NamedThing phosphopantetheine binding Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). got7fsn_ti molecular_function owl:Class
GO:0080109 biolink:NamedThing indole-3-acetonitrile nitrile hydratase activity Catalysis of the reaction: indole-3-acetonitrile + H2O = indole-3-acetamide. got7fsn_ti dhl 2009-04-23T04:37:57Z KEGG_REACTION:R04020|MetaCyc:RXN-7567|EC:4.2.1.84 molecular_function owl:Class
GO:0075001 biolink:NamedThing adhesion of symbiont infection structure to host The attachment of an infection structure of the symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti attachment of symbiont infection structure to host|adhesion of symbiont infection structure to host during symbiotic interaction Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products of the symbiont involved in this process. biological_process owl:Class
GO:0002420 biolink:NamedThing natural killer cell mediated cytotoxicity directed against tumor cell target The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. got7fsn_ti NK cell mediated cytotoxicity directed against tumor cell target Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. biological_process owl:Class
GO:0051550 biolink:NamedThing aurone metabolic process The chemical reactions and pathways involving aurones, a series of plant flavonoids that provide a yellow colour to flowers. They have the basic skeletal structure of two benzene rings joined by a linear C3 chain (C6-C3-C6). Aurones exist mostly as 6-O-glucosides. got7fsn_ti benzalcoumaran-3-one metabolism|benzalcoumaran-3-one metabolic process|aurone metabolism biological_process owl:Class
GO:0042440 biolink:NamedThing pigment metabolic process The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin. got7fsn_ti pigment metabolism biological_process owl:Class
GO:0045926 biolink:NamedThing negative regulation of growth Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism. got7fsn_ti downregulation of growth|inhibition of growth|down-regulation of growth|down regulation of growth biological_process owl:Class
GO:0032472 biolink:NamedThing Golgi calcium ion transport The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus. got7fsn_ti Golgi calcium transport biological_process owl:Class
GO:0006816 biolink:NamedThing calcium ion transport The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti calcium transport|sodium:calcium exchange|mitochondrial sodium/calcium ion exchange biological_process owl:Class
GO:0044862 biolink:NamedThing protein transport out of plasma membrane raft The directed movement of a protein out of a plasma membrane raft. got7fsn_ti jl 2014-07-23T16:32:56Z biological_process owl:Class
GO:0016460 biolink:NamedThing myosin II complex A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. got7fsn_ti conventional myosin cellular_component owl:Class
GO:0050595 biolink:NamedThing 7-deoxyloganin 7-hydroxylase activity Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O. got7fsn_ti 7-deoxyloganin,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) MetaCyc:1.14.13.74-RXN|RHEA:11452|EC:1.14.13.74 molecular_function owl:Class
GO:0032987 biolink:NamedThing protein-lipid complex disassembly The disaggregation of a protein-lipid complex into its constituent components. got7fsn_ti biological_process owl:Class
GO:0071825 biolink:NamedThing protein-lipid complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-lipid complex. got7fsn_ti protein-lipid complex subunit organisation mah 2010-09-08T10:04:36Z biological_process owl:Class
GO:0102813 biolink:NamedThing UDP-D-glucose:cyanidin 3-(p-coumaroyl)-glucoside 5-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-(p-coumaroyl)-glucoside = shisonin + UDP + H+. got7fsn_ti MetaCyc:RXN-8205 molecular_function owl:Class
GO:2000167 biolink:NamedThing regulation of planar cell polarity pathway involved in neural tube closure Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure. got7fsn_ti dph 2010-10-05T01:08:53Z biological_process owl:Class
GO:0090733 biolink:NamedThing tenascin complex A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R. got7fsn_ti Tenascin-R|Tenascin-X|Tenascin-C|Tenascin-W|Tenascin-N An example is Tenascin-N (Q9UQP3) in PMID:17909022 (IDA). tb 2017-02-01T16:29:55Z cellular_component owl:Class
GO:0098637 biolink:NamedThing protein complex involved in cell-matrix adhesion Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion. got7fsn_ti cellular_component owl:Class
GO:0106147 biolink:NamedThing fraxetin biosynthesis The chemical reactions and pathways resulting in the formation of fraxetin. got7fsn_ti hjd 2018-09-07T18:32:47Z biological_process owl:Class
GO:0009805 biolink:NamedThing coumarin biosynthetic process The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids. got7fsn_ti coumarin anabolism|coumarin formation|coumarin biosynthesis|coumarin synthesis MetaCyc:PWY-5176 biological_process owl:Class
GO:0031801 biolink:NamedThing type 4 metabotropic glutamate receptor binding Binding to a type 4 metabotropic glutamate receptor. got7fsn_ti type 4 metabotropic glutamate receptor ligand molecular_function owl:Class
GO:0007052 biolink:NamedThing mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. got7fsn_ti mitotic spindle organization and biogenesis in nucleus|mitotic spindle organization and biogenesis|mitotic spindle organisation in nucleus|mitotic spindle organisation|spindle organization and biogenesis during mitosis|spindle organization and biogenesis in nucleus during mitosis|mitotic spindle organization in nucleus|mitotic spindle stabilization|mitotic spindle organization and biogenesis in cell nucleus https://github.com/geneontology/go-ontology/issues/15341 In fission yeast most mitotic spindle organization occurs in the nucleus. GO:0030472|GO:0000071|GO:0043148 biological_process owl:Class
GO:1902850 biolink:NamedThing microtubule cytoskeleton organization involved in mitosis Any microtubule cytoskeleton organization that is involved in mitosis. got7fsn_ti microtubule dynamics involved in mitosis|microtubule cytoskeleton organisation involved in mitosis|microtubule cytoskeleton organization and biogenesis involved in mitosis vw 2014-04-02T14:19:38Z biological_process owl:Class
GO:0017117 biolink:NamedThing single-stranded DNA-dependent ATP-dependent DNA helicase complex A protein complex that possesses single-stranded DNA-dependent DNA helicase activity. got7fsn_ti ssDNA-dependent ATP-dependent DNA helicase complex cellular_component owl:Class
GO:0080163 biolink:NamedThing regulation of protein serine/threonine phosphatase activity Any process that modulates the frequency, rate or extent of protein serine/threonine phosphatase activity: catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. got7fsn_ti regulation of protein phosphatase type 2c activity dhl 2010-09-23T03:51:37Z biological_process owl:Class
GO:0043666 biolink:NamedThing regulation of phosphoprotein phosphatase activity Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein. got7fsn_ti regulation of protein phosphatase type 2A activity|regulation of protein phosphatase type 2B activity|regulation of protein phosphatase type 2 activity|regulation of calcineurin activity|regulation of protein phosphatase 3 activity GO:0034047|GO:0032512 biological_process owl:Class
GO:1990767 biolink:NamedThing prostaglandin receptor internalization The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle. got7fsn_ti sl 2015-06-10T19:14:08Z biological_process owl:Class
GO:0002031 biolink:NamedThing G protein-coupled receptor internalization The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle. got7fsn_ti G-protein coupled receptor internalization biological_process owl:Class
GO:0099111 biolink:NamedThing microtubule-based transport A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. got7fsn_ti biological_process owl:Class
GO:0047089 biolink:NamedThing dihydrochelirubine 12-monooxygenase activity Catalysis of the reaction: dihydrochelirubine + H(+) + NADPH + O(2) = 12-hydroxydihydrochelirubine + H(2)O + NADP(+). got7fsn_ti dihydrochelirubine,NADPH:oxygen oxidoreductase (12-hydroxylating)|dihydrochelirubine 12-hydroxylase activity KEGG_REACTION:R04708|MetaCyc:1.14.13.57-RXN|EC:1.14.14.101|RHEA:10156 molecular_function owl:Class
GO:0106313 biolink:NamedThing methylenetetrahydrofolate reductase NADPH activity Catalysis of the reaction: 5-methyltetrahydrofolate + NADP + = 5,10-methylenetetrahydrofolate + NADPH + H+. got7fsn_ti hjd 2020-09-23T14:20:27Z RHEA:19817 molecular_function owl:Class
GO:0004489 biolink:NamedThing methylenetetrahydrofolate reductase (NAD(P)H) activity Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. got7fsn_ti methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity|5-methyltetrahydrofolate:NADP(+) oxidoreductase activity|5,10-CH2-H4folate reductase activity|MetF|5,10-methylenetetrahydropteroylglutamate reductase activity|5-methyltetrahydrofolate:NAD(+) oxidoreductase activity|5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity|N(5),N(10)-methylenetetrahydrofolate reductase activity|N5,10-methylenetetrahydrofolate reductase activity|5-methyltetrahydrofolate:(acceptor) oxidoreductase activity|5-methyltetrahydrofolate:NAD+ oxidoreductase activity|5-methyltetrahydrofolate:NAD oxidoreductase activity|5,10-methylenetetrahydrofolate reductase (NADPH) activity|methylenetetrahydrofolate reductase activity|methylenetetrahydrofolate reductase (NADPH(2)) activity|5,10-methylenetetrahydrofolate reductase (FADH(2)) activity|MTHFR activity|5,10-CH(2)-H(4)folate reductase activity|5,10-methylenetetrahydrofolate reductase (FADH) activity|5-methyltetrahydrofolate:NADP+ oxidoreductase activity|methylenetetrahydrofolic acid reductase activity|5,10-methylenetetrahydrofolate reductase activity|methylenetetrahydrofolate reductase [NAD(P)H]|methylenetetrahydrofolate reductase (NADPH2)|methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|N5,N10-methylenetetrahydrofolate reductase activity|5,10-methylenetetrahydrofolate reductase (FADH2) activity|N(5,10)-methylenetetrahydrofolate reductase activity|5,10-methylenetetrahydrofolic acid reductase activity GO:0008702 KEGG_REACTION:R01224|KEGG_REACTION:R07168|MetaCyc:1.5.1.20-RXN|Reactome:R-HSA-200676|EC:1.5.1.20 molecular_function owl:Class
GO:0070761 biolink:NamedThing pre-snoRNP complex A ribonucleoprotein complex that contains a precursor small nucleolar RNA (pre-snoRNA) and associated proteins, and forms during small nucleolar ribonucleoprotein complex (snoRNP) assembly. Pre-snoRNP complexes may contain proteins not found in the corresponding mature snoRNP complexes. got7fsn_ti pre-small nucleolar ribonucleoprotein complex mah 2009-06-23T02:32:10Z cellular_component owl:Class
GO:0008399 biolink:NamedThing naphthalene hydroxylase activity Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide. got7fsn_ti cytochrome P450 CYP2F2 molecular_function owl:Class
GO:1990359 biolink:NamedThing stress response to zinc ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a zinc ion stimulus. got7fsn_ti response to zinc ion stress|response to zinc toxicity|stress response to zinc kmv 2014-04-14T15:54:05Z biological_process owl:Class
GO:0097501 biolink:NamedThing stress response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus. got7fsn_ti response to excess metal ion|response to metal toxicity|response to metal ion stress|response to metal ion toxicity pr 2013-08-15T10:37:45Z biological_process owl:Class
GO:0002223 biolink:NamedThing stimulatory C-type lectin receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation. got7fsn_ti stimulatory Ly49 family receptor signaling pathway|stimulatory C-type lectin receptor signalling pathway biological_process owl:Class
GO:1990858 biolink:NamedThing cellular response to lectin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. got7fsn_ti This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity. sl 2015-09-24T15:34:42Z biological_process owl:Class
GO:0090110 biolink:NamedThing COPII-coated vesicle cargo loading The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi. got7fsn_ti cargo loading into COPII-coated vesicle|cargo loading into COPII vesicle|cargo selection into COPII-coated vesicle|COPII coat-cargo complex assembly tb 2009-12-06T08:28:34Z biological_process owl:Class
GO:0008397 biolink:NamedThing sterol 12-alpha-hydroxylase activity Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O. got7fsn_ti cytochrome P450 CYP8B1 molecular_function owl:Class
GO:0090463 biolink:NamedThing lysine homeostasis Any process involved in the maintenance of an internal steady state of lysine within an organism or cell. got7fsn_ti tb 2012-09-24T14:22:02Z biological_process owl:Class
GO:0009513 biolink:NamedThing etioplast A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions. got7fsn_ti Wikipedia:Etioplast cellular_component owl:Class
GO:0080090 biolink:NamedThing regulation of primary metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. got7fsn_ti dhl 2009-04-22T04:30:52Z biological_process owl:Class
GO:0097685 biolink:NamedThing dinoflagellate apical groove A cell surface furrow (or groove) found on a dinoflagellate apex. It typically loops around the apex. got7fsn_ti apical groove The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. pr 2014-12-18T09:34:52Z cellular_component owl:Class
GO:0004112 biolink:NamedThing cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. got7fsn_ti molecular_function owl:Class
GO:0000032 biolink:NamedThing cell wall mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues. got7fsn_ti cell wall mannoprotein synthesis|cell wall mannoprotein anabolism|cell wall mannoprotein formation|cell wall mannoprotein biosynthesis biological_process owl:Class
GO:0006057 biolink:NamedThing mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of a mannoprotein, a protein that contains covalently bound mannose residues. got7fsn_ti mannoprotein anabolism|mannoprotein biosynthesis|mannoprotein synthesis|mannoprotein formation biological_process owl:Class
GO:0048358 biolink:NamedThing mucilage pectin biosynthetic process The chemical reactions and pathways resulting in the formation of the pectin component of mucilage. got7fsn_ti mucilage pectin formation|mucilage pectin synthesis|mucilage pectin anabolism|mucilage pectin biosynthesis biological_process owl:Class
GO:0045489 biolink:NamedThing pectin biosynthetic process The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. got7fsn_ti pectin formation|pectin anabolism|pectin synthesis|pectin biosynthesis biological_process owl:Class
GO:0035100 biolink:NamedThing ecdysone binding Binding to 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting. got7fsn_ti molecular_function owl:Class
GO:0061413 biolink:NamedThing regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. got7fsn_ti dph 2012-01-23T11:13:06Z biological_process owl:Class
GO:0008897 biolink:NamedThing holo-[acyl-carrier-protein] synthase activity Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. got7fsn_ti phosphopantetheinyl transferase|acyl carrier protein holoprotein (holo-ACP) synthetase activity|acyl carrier protein synthase activity|P-pant transferase activity|holo-ACP synthase activity|holo-ACP synthetase activity|coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity|phosphopantetheinyltransferase activity|4'-phosphopantetheinyltransferase activity|holo-[peptidyl-carrier protein] synthase activity|alpha-aminoadipate reductase phosphopantetheinyl transferase activity|PPTase activity|CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity|alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity|ACPS activity|acyl carrier protein synthetase activity|CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity|holo-[acyl-carrier-protein] synthase activity|4'-phosphopantetheinyl transferase activity|alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity|holosynthase activity|L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity|AcpS|holo-acyl-carrier-protein synthase activity https://github.com/geneontology/go-ontology/issues/18113 GO:0008958 MetaCyc:HOLO-ACP-SYNTH-RXN|EC:2.7.8.7|Reactome:R-HSA-199202|RHEA:12068 molecular_function owl:Class
GO:0098601 biolink:NamedThing selenomethionine adenosyltransferase activity Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine. got7fsn_ti dos 2014-04-15T15:15:03Z Reactome:R-HSA-2408551|RHEA:31211 molecular_function owl:Class
GO:0021788 biolink:NamedThing chemoattraction of branchiomotor neuron axon in neural tube The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti positive chemotaxis of branchiomotor neuron axon in neural tube biological_process owl:Class
GO:0021792 biolink:NamedThing chemoattraction of branchiomotor axon The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti positive chemotaxis of branchiomotor axon biological_process owl:Class
GO:0071598 biolink:NamedThing neuronal ribonucleoprotein granule A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli. got7fsn_ti neuronal RNA granule|neuronal RNP granule mah 2010-02-04T04:01:57Z cellular_component owl:Class
GO:0036464 biolink:NamedThing cytoplasmic ribonucleoprotein granule A ribonucleoprotein granule located in the cytoplasm. got7fsn_ti Staufen granule bf 2014-06-18T09:44:44Z cellular_component owl:Class
GO:0097082 biolink:NamedThing vascular associated smooth muscle cell fate specification The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. got7fsn_ti vascular smooth muscle cell fate specification pr 2011-06-20T03:56:21Z biological_process owl:Class
GO:0042694 biolink:NamedThing muscle cell fate specification The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0097280 biolink:NamedThing histamine secretion mediated by immunoglobulin Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface. got7fsn_ti pr 2012-03-26T01:30:25Z biological_process owl:Class
GO:0002437 biolink:NamedThing inflammatory response to antigenic stimulus An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. got7fsn_ti biological_process owl:Class
GO:0002630 biolink:NamedThing positive regulation of proteolysis associated with antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. got7fsn_ti stimulation of proteolysis associated with antigen processing and presentation|activation of proteolysis associated with antigen processing and presentation|upregulation of proteolysis associated with antigen processing and presentation|up-regulation of proteolysis associated with antigen processing and presentation|up regulation of proteolysis associated with antigen processing and presentation biological_process owl:Class
GO:0045732 biolink:NamedThing positive regulation of protein catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. got7fsn_ti positive regulation of protein degradation|up regulation of protein catabolic process|activation of protein catabolic process|positive regulation of protein breakdown|upregulation of protein catabolic process|up-regulation of protein catabolic process|stimulation of protein catabolic process|positive regulation of protein catabolism biological_process owl:Class
GO:0009777 biolink:NamedThing photosynthetic phosphorylation Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation. got7fsn_ti photosynthetic ATP synthesis biological_process owl:Class
GO:0016310 biolink:NamedThing phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. got7fsn_ti Wikipedia:Phosphorylation biological_process owl:Class
GO:0047547 biolink:NamedThing 2-methylcitrate dehydratase activity Catalysis of the reaction: (2S,3S)-2-methylcitrate = cis-2-methylaconitate + H(2)O. got7fsn_ti prpD|2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity|2-methylcitrate hydro-lyase activity|(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] RHEA:17725|EC:4.2.1.79|KEGG_REACTION:R04424|MetaCyc:2-METHYLCITRATE-DEHYDRATASE-RXN molecular_function owl:Class
GO:0021688 biolink:NamedThing cerebellar molecular layer formation The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. got7fsn_ti biological_process owl:Class
GO:0047410 biolink:NamedThing N-formylmethionylaminoacyl-tRNA deformylase activity Catalysis of the reaction: H2O + charged-fMet-tRNAs = L-methionylaminoacyl-tRNA + formate. got7fsn_ti N-formyl-L-methionylaminoacyl-tRNA amidohydrolase activity MetaCyc:3.5.1.27-RXN molecular_function owl:Class
GO:0010178 biolink:NamedThing IAA-amino acid conjugate hydrolase activity Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid. got7fsn_ti molecular_function owl:Class
GO:0018274 biolink:NamedThing peptide cross-linking via L-lysinoalanine The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link. got7fsn_ti RESID:AA0123 biological_process owl:Class
GO:0021772 biolink:NamedThing olfactory bulb development The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex. got7fsn_ti biological_process owl:Class
GO:1990729 biolink:NamedThing primary miRNA modification The covalent alteration of one or more nucleotides within a primary miRNA molecule to produce a primary miRNA molecule with a sequence that differs from that coded genetically. got7fsn_ti sp 2015-04-16T06:19:22Z biological_process owl:Class
GO:0046896 biolink:NamedThing N-terminal peptidyl-leucine methylation The methylation of the N-terminal leucine of proteins to form the derivative N-methyl-L-leucine. got7fsn_ti RESID:AA0337 biological_process owl:Class
GO:0052892 biolink:NamedThing aromatic (S)-hydroxynitrile lyase activity Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide. got7fsn_ti (S)-hydroxynitrile lyase activity|(S)-cyanohydrin producing hydroxynitrile lyase activity|(S)-oxynitrilase activity|(S)-selective hydroxynitrile lyase activity|hydroxynitrile lyase activity|oxynitrilase activity|(S)-cyanohydrin carbonyl-lyase (cyanide forming) activity MetaCyc:RXN-11732|RHEA:54660|EC:4.1.2.47|KEGG_REACTION:R09359 molecular_function owl:Class
GO:0008733 biolink:NamedThing L-arabinose isomerase activity Catalysis of the reaction: L-arabinose = L-ribulose. got7fsn_ti L-arabinose ketol-isomerase activity|L-arabinose aldose-ketose-isomerase activity RHEA:14821|EC:5.3.1.4|KEGG_REACTION:R01761|MetaCyc:ARABISOM-RXN molecular_function owl:Class
GO:1990099 biolink:NamedThing pre-primosome complex Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component. got7fsn_ti pre-primosome|pre-priming complex|preprimosome|prereplication complex|preprimosome complex|pre-replication complex bhm 2013-05-14T10:53:42Z cellular_component owl:Class
GO:0070553 biolink:NamedThing nicotinic acid receptor activity Combining with nicotinic acid to initiate a change in cell activity. got7fsn_ti niacin receptor activity molecular_function owl:Class
GO:0070711 biolink:NamedThing RNA adenosine-uridine insertion The modification of an RNA molecule by insertion of an adenosine-uridine dinucleotide. got7fsn_ti RNA AU insertion mah 2009-06-08T05:16:39Z biological_process owl:Class
GO:0070707 biolink:NamedThing RNA dinucleotide insertion The modification of an RNA molecule by insertion of a dinucleotide. got7fsn_ti mah 2009-06-08T04:50:59Z biological_process owl:Class
GO:0106369 biolink:NamedThing GTP dependent (deoxy)nucleoside -phosphate kinase activity Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP. got7fsn_ti hjd 2021-03-11T20:12:21Z RHEA:62124 molecular_function owl:Class
GO:0033933 biolink:NamedThing branched-dextran exo-1,2-alpha-glucosidase activity Catalysis of the hydrolysis of (1->2)-alpha-D-glucosidic linkages at the branch points of dextrans and related polysaccharides, producing free D-glucose. got7fsn_ti dextran alpha-1,2 debranching enzyme|1,2-alpha-D-glucosyl-branched-dextran 2-glucohydrolase activity|dextran 1,2-alpha-glucosidase activity MetaCyc:3.2.1.115-RXN|EC:3.2.1.115 molecular_function owl:Class
GO:0099557 biolink:NamedThing trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0070845 biolink:NamedThing polyubiquitinated misfolded protein transport The directed movement of misfolded polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. got7fsn_ti misfolded polyubiquitinated protein transport|polyubiquitylated misfolded protein transport mah 2009-07-31T12:52:26Z biological_process owl:Class
GO:0070844 biolink:NamedThing polyubiquitinated protein transport The directed movement of polyubiquitinated proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. got7fsn_ti polyubiquitylated protein transport mah 2009-07-31T12:51:10Z biological_process owl:Class
GO:0052335 biolink:NamedThing modification by host of symbiont cytoskeleton The process in which an organism effects a change in the structure or function of the symbiont cytoskeleton. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0052187 biolink:NamedThing modification by host of symbiont cellular component The process in which an organism effects a change in the structure or function of a symbiont cellular component. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:1990502 biolink:NamedThing dense core granule maturation Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis. got7fsn_ti dense core vesicle maturation kmv 2014-09-30T20:35:11Z biological_process owl:Class
GO:0050503 biolink:NamedThing trehalose 6-phosphate phosphorylase activity Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate. got7fsn_ti trehalose 6-phosphate:phosphate beta-D-glucosyltransferase activity RHEA:20864|MetaCyc:2.4.1.216-RXN|EC:2.4.1.216 molecular_function owl:Class
GO:0014063 biolink:NamedThing negative regulation of serotonin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. got7fsn_ti downregulation of serotonin secretion|down regulation of serotonin secretion|down-regulation of serotonin secretion|inhibition of serotonin secretion|positive regulation of serotonin release biological_process owl:Class
GO:0097502 biolink:NamedThing mannosylation The covalent attachment of a mannose residue to a substrate molecule. got7fsn_ti pr 2013-09-20T09:47:40Z biological_process owl:Class
GO:0070085 biolink:NamedThing glycosylation The covalent attachment and further modification of carbohydrate residues to a substrate molecule. got7fsn_ti Wikipedia:Glycosylation biological_process owl:Class
GO:0075713 biolink:NamedThing establishment of integrated proviral latency A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage. got7fsn_ti provirus integration|prophage integration jl 2009-05-07T02:28:41Z GO:0019047 VZ:980 biological_process owl:Class
GO:0019043 biolink:NamedThing establishment of viral latency A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects. got7fsn_ti phage lysogeny|lysogenic commitment GO:0075601 biological_process owl:Class
GO:0010036 biolink:NamedThing response to boron-containing substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus. got7fsn_ti response to boron biological_process owl:Class
GO:1990457 biolink:NamedThing pexophagosome A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy. got7fsn_ti dhl 2014-08-15T18:51:53Z cellular_component owl:Class
GO:0045335 biolink:NamedThing phagocytic vesicle A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. got7fsn_ti phagosome Wikipedia:Phagosome cellular_component owl:Class
GO:0006696 biolink:NamedThing ergosterol biosynthetic process The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. got7fsn_ti ergosterol biosynthesis|ergosterol anabolism|ergosterol synthesis|ergosterol formation biological_process owl:Class
GO:0042242 biolink:NamedThing cobyrinic acid a,c-diamide synthase activity Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide. got7fsn_ti cobyrinate a,c-diamide synthase activity|CobB|cobyrinate a,c diamide synthase activity|cobyrinate a c diamide synthase activity|cobyrinate a c-diamide synthase activity GO:0043775 RHEA:26289|EC:6.3.5.11 molecular_function owl:Class
GO:0016884 biolink:NamedThing carbon-nitrogen ligase activity, with glutamine as amido-N-donor Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16422 GO:0016003 EC:6.3.5.- molecular_function owl:Class
GO:0060201 biolink:NamedThing clathrin-sculpted acetylcholine transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted acetylcholine transport vesicle. got7fsn_ti clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle membrane|clathrin sculpted acetylcholine transport vesicle membrane cellular_component owl:Class
GO:0045247 biolink:NamedThing cytosolic electron transfer flavoprotein complex A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors. got7fsn_ti cellular_component owl:Class
GO:0061652 biolink:NamedThing FAT10 conjugating enzyme activity Isoenergetic transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y -> Y-FAT10 + X, where both the X-FAT10 and Y-FAT10 linkages are thioester bonds between the C-terminal amino acid of FAT10 and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:21:50Z molecular_function owl:Class
GO:0051707 biolink:NamedThing response to other organism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism. got7fsn_ti GO:0042828|GO:0009613 biological_process owl:Class
GO:0031787 biolink:NamedThing H9 melatonin receptor binding Binding to a H9 melatonin receptor. got7fsn_ti H9 melatonin receptor ligand molecular_function owl:Class
GO:0008311 biolink:NamedThing double-stranded DNA 3'-5' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. got7fsn_ti double-stranded DNA specific 3'-5' exodeoxyribonuclease activity molecular_function owl:Class
GO:0120325 biolink:NamedThing NuRD complex binding Binding to a NuRD complex. got7fsn_ti krc 2021-08-03T21:15:31Z molecular_function owl:Class
GO:0070700 biolink:NamedThing BMP receptor binding Binding to a BMP receptor. got7fsn_ti bone morphogenetic protein receptor binding mah 2009-06-04T04:24:16Z molecular_function owl:Class
GO:0043116 biolink:NamedThing negative regulation of vascular permeability Any process that reduces the extent to which blood vessels can be pervaded by fluid. got7fsn_ti down regulation of vascular permeability|downregulation of vascular permeability|down-regulation of vascular permeability|inhibition of vascular permeability biological_process owl:Class
GO:0003029 biolink:NamedThing detection of hypoxic conditions in blood by carotid body chemoreceptor signaling The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies. got7fsn_ti detection of hypoxic conditions in blood by carotid body chemoreceptor signalling biological_process owl:Class
GO:0034925 biolink:NamedThing pyrene 4,5-monooxygenase activity Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O. got7fsn_ti UM-BBD_reactionID:r0941 molecular_function owl:Class
GO:0102263 biolink:NamedThing tRNA-dihydrouridine17 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil17 in tRNA + NAD(P) <=> H+ + a uracil17 in tRNA + NAD(P)H. got7fsn_ti EC:1.3.1.88|MetaCyc:RXN-12455 molecular_function owl:Class
GO:0050110 biolink:NamedThing mucinaminylserine mucinaminidase activity Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine. got7fsn_ti endo-beta-N-acetyl-D-galactosaminidase activity|endo-beta-N-acetylgalactosaminidase|D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine mucinaminohydrolase activity MetaCyc:3.2.1.110-RXN|KEGG_REACTION:R04527|EC:3.2.1.97 molecular_function owl:Class
GO:0035489 biolink:NamedThing guanine/guanine mispair binding Binding to a double-stranded DNA region containing a G/G mispair. got7fsn_ti G/G mispair binding bf 2010-04-23T11:16:55Z molecular_function owl:Class
GO:0070946 biolink:NamedThing neutrophil-mediated killing of gram-positive bacterium The directed killing of a gram-positive bacterium by a neutrophil. got7fsn_ti neutrophil mediated killing of gram-positive bacterium mah 2009-10-01T02:04:15Z biological_process owl:Class
GO:0050700 biolink:NamedThing CARD domain binding Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. got7fsn_ti molecular_function owl:Class
GO:0001567 biolink:NamedThing cholesterol 25-hydroxylase activity Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O. got7fsn_ti cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity|cholesterol 25-monooxygenase activity EC:1.14.99.38|RHEA:21104|KEGG_REACTION:R07218|MetaCyc:1.14.99.38-RXN molecular_function owl:Class
GO:0070089 biolink:NamedThing chloride-activated potassium channel activity Enables the chloride concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. got7fsn_ti molecular_function owl:Class
GO:0050294 biolink:NamedThing steroid sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate. got7fsn_ti 3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase activity|steroid alcohol sulfotransferase|steroid sulphotransferase activity Reactome:R-HSA-176521|EC:2.8.2.15|MetaCyc:STEROID-SULFOTRANSFERASE-RXN|Reactome:R-HSA-176517|Reactome:R-HSA-176631 molecular_function owl:Class
GO:0045939 biolink:NamedThing negative regulation of steroid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. got7fsn_ti down-regulation of steroid metabolic process|downregulation of steroid metabolic process|down regulation of steroid metabolic process|inhibition of steroid metabolic process|negative regulation of steroid metabolism biological_process owl:Class
GO:0019218 biolink:NamedThing regulation of steroid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids. got7fsn_ti regulation of steroid metabolism biological_process owl:Class
GO:0043293 biolink:NamedThing apoptosome A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms. got7fsn_ti Wikipedia:Apoptosome cellular_component owl:Class
GO:0044675 biolink:NamedThing formyl-methanofuran dehydrogenase (tungsten enzyme) complex A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis. got7fsn_ti jl 2012-08-09T10:54:49Z cellular_component owl:Class
GO:0036414 biolink:NamedThing histone citrullination The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein. got7fsn_ti histone deimination bf 2013-08-22T14:04:26Z biological_process owl:Class
GO:0015979 biolink:NamedThing photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. got7fsn_ti Wikipedia:Photosynthesis biological_process owl:Class
GO:0050277 biolink:NamedThing sedoheptulokinase activity Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate. got7fsn_ti ATP:sedoheptulose 7-phosphotransferase activity|sedoheptulokinase (phosphorylating)|heptulokinase activity RHEA:23844|Reactome:R-HSA-8959719|KEGG_REACTION:R01844|EC:2.7.1.14|MetaCyc:SEDOHEPTULOKINASE-RXN molecular_function owl:Class
GO:0102446 biolink:NamedThing rhamnetin 3-O-methyltransferase activity Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-13932 molecular_function owl:Class
GO:0021954 biolink:NamedThing central nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. got7fsn_ti biological_process owl:Class
GO:0048666 biolink:NamedThing neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0002413 biolink:NamedThing tolerance induction to tumor cell A process of tolerance induction which leads to immunological tolerance of a tumor. got7fsn_ti biological_process owl:Class
GO:0002465 biolink:NamedThing peripheral tolerance induction Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. got7fsn_ti biological_process owl:Class
GO:0031766 biolink:NamedThing type 3 galanin receptor binding Binding to a type 3 galanin receptor. got7fsn_ti type 3 galanin receptor ligand molecular_function owl:Class
GO:0031763 biolink:NamedThing galanin receptor binding Binding to a galanin receptor. got7fsn_ti galanin receptor ligand molecular_function owl:Class
GO:0043898 biolink:NamedThing 2,3-dihydroxybiphenyl 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid. got7fsn_ti 2,3-dihydroxybiphenyl-1,2-dioxygenase activity|BphC molecular_function owl:Class
GO:0043532 biolink:NamedThing angiostatin binding Binding to angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis. got7fsn_ti molecular_function owl:Class
GO:0140358 biolink:NamedThing P-type transmembrane transporter activity Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. got7fsn_ti E1-E2 ATPase|P-type ATPase https://github.com/geneontology/go-ontology/issues/21273|https://github.com/geneontology/go-ontology/issues/20529 pg 2019-06-25T19:07:46Z TC:3.A.3|Wikipedia:P-type_ATPase molecular_function owl:Class
GO:0042626 biolink:NamedThing ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. got7fsn_ti P-P-bond-hydrolysis-driven transporter|ATPase activity, coupled to movement of substances|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|P-P-bond-hydrolysis-driven transmembrane transporter activity|ATP-dependent transmembrane transporter activity|ATP-coupled transmembrane transporter activity|ATPase activity, coupled to transmembrane movement of substances https://github.com/geneontology/go-ontology/issues/19965|https://github.com/geneontology/go-ontology/issues/17373|https://github.com/geneontology/go-ontology/issues/14642 GO:0016820|GO:0043492|GO:0015405 Reactome:R-HSA-2161506|Reactome:R-HSA-1467457|Reactome:R-HSA-9033505|Reactome:R-HSA-2161538|Reactome:R-HSA-9033499 molecular_function owl:Class
GO:0097557 biolink:NamedThing right posteriolateral flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body. got7fsn_ti right posterolateral flagellum|right posterolateral cilium|right posteriolateral cilium Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T13:24:55Z cellular_component owl:Class
GO:0052029 biolink:NamedThing suppression by symbiont of host signal transduction pathway Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the host signal transduction pathways, the cascade of processes by which a signal interacts with a receptor. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by organism of signal transduction in other organism involved in symbiotic interaction|negative regulation by symbiont of host signal transduction pathway|inhibition by symbiont of host signal transduction pathway|down regulation by symbiont of host signal transduction pathway|down-regulation by symbiont of host signal transduction pathway|negative modulation by organism of host signal transduction pathway|downregulation by symbiont of host signal transduction pathway GO:0052493 biological_process owl:Class
GO:0032441 biolink:NamedThing pheophorbide a oxygenase activity Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O. got7fsn_ti MetaCyc:RXN-7740|RHEA:48140|EC:1.14.15.17 molecular_function owl:Class
GO:0016730 biolink:NamedThing oxidoreductase activity, acting on iron-sulfur proteins as donors Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on iron-sulphur proteins as donors EC:1.18.-.- molecular_function owl:Class
GO:0043812 biolink:NamedThing phosphatidylinositol-4-phosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate. got7fsn_ti phosphatidylinositol 4-phosphate phosphatase activity molecular_function owl:Class
GO:0052744 biolink:NamedThing phosphatidylinositol monophosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate. got7fsn_ti ai 2011-09-14T01:36:39Z molecular_function owl:Class
GO:0080014 biolink:NamedThing thalianol hydroxylase activity Catalysis of the reaction: a thalianol = a thalian-diol. This reaction is the addition of a hydroxyl group to thalianol ((13R,14R,17E)-podioda-8,17,21-trien-3beta-ol) to create a thalian-diol ((13R,14R,17E)-podioda-8,17,21-trien-3beta,X-diol), where the hydroxyl group may be attached at one of several different available carbons in ring B or C of thalianol, indicated by the X. got7fsn_ti In Field and Osbourn 2008 (PMID:18356490), thalianol is referred to as (3S,13S,3R)-malabarica-8,17,21-trien-3-ol and thalian-diol is referred to as (3S,13S,14R)-malabarica-8,17,21-trien-3,?-diol, but the error in this naming system was pointed out in Kolesnikova 2007 (PMID:17474751). The new names used in the definition have been approved by the authors (Field and Osbourn 2008). EC:1.14.13.-|MetaCyc:RXN-9631 molecular_function owl:Class
GO:0061836 biolink:NamedThing intranuclear rod A macromolecular fiber consisting of actin and cofilin that is formed in the nucleus as a consequence of chemical or mechanical stress conditions. got7fsn_ti intranuclear actin rod cellular_component owl:Class
GO:0099512 biolink:NamedThing supramolecular fiber A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. got7fsn_ti fibril GO:0043205 cellular_component owl:Class
GO:0047087 biolink:NamedThing protopine 6-monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + protopine = 6-hydroxyprotopine + H(2)O + NADP(+). got7fsn_ti protopine 6-hydroxylase activity|protopine,NADPH:oxygen oxidoreductase (6-hydroxylating) EC:1.14.14.98|RHEA:22644|MetaCyc:1.14.13.55-RXN|KEGG_REACTION:R04699 molecular_function owl:Class
GO:0001501 biolink:NamedThing skeletal system development The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). got7fsn_ti skeletal development biological_process owl:Class
GO:0021938 biolink:NamedThing smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells. got7fsn_ti hh signaling pathway involved in regulation of granule cell precursor cell proliferation|hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation|smoothened signalling pathway in regulation of granule cell precursor cell proliferation biological_process owl:Class
GO:0007224 biolink:NamedThing smoothened signaling pathway A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. got7fsn_ti hh signaling pathway|smoothened signalling pathway|Sonic hedgehog signaling pathway|hedgehog signaling pathway|hh signalling pathway|Shh signaling pathway Wikipedia:Hedgehog_signaling_pathway biological_process owl:Class
GO:0014744 biolink:NamedThing positive regulation of muscle adaptation Any process that activates or increases the frequency, rate or extent of muscle adaptation. got7fsn_ti positive regulation of muscle plasticity biological_process owl:Class
GO:0010137 biolink:NamedThing ureide biosynthetic process The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots. got7fsn_ti ureide biosynthesis|ureide synthesis|ureide anabolism|ureide formation MetaCyc:URSIN-PWY biological_process owl:Class
GO:0010135 biolink:NamedThing ureide metabolic process The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants. got7fsn_ti ureide metabolism biological_process owl:Class
GO:1990892 biolink:NamedThing mitotic chromosome arm condensation The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells. got7fsn_ti vw 2015-11-03T14:16:59Z biological_process owl:Class
GO:0007076 biolink:NamedThing mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells. got7fsn_ti biological_process owl:Class
GO:0140691 biolink:NamedThing RNA folding chaperone Binding to an RNA or an RNA-containing complex to assist the folding process. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21913 pg 2021-08-04T07:48:29Z molecular_function owl:Class
GO:0018707 biolink:NamedThing 1-phenanthrol methyltransferase activity Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene. got7fsn_ti UM-BBD_reactionID:r0493 molecular_function owl:Class
GO:0018852 biolink:NamedThing dichloromuconate cycloisomerase activity Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate. got7fsn_ti 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN|EC:5.5.1.11|UM-BBD_reactionID:r0277|RHEA:17437 molecular_function owl:Class
GO:0047096 biolink:NamedThing androst-4-ene-3,17-dione monooxygenase activity Catalysis of the reaction: AH(2) + androst-4-ene-3,17-dione + O(2) = A + H(2)O + testololactone. got7fsn_ti androst-4-ene-3,17-dione 17-oxidoreductase activity|androst-4-ene-3,17-dione hydroxylase activity|androstene-3,17-dione hydroxylase activity|4-androstene-3,17-dione monooxygenase activity|androst-4-ene-3,17-dione-hydrogen-donor:oxygen oxidoreductase (13-hydroxylating, lactonizing)|androstenedione monooxygenase activity KEGG_REACTION:R01833|RHEA:22696|EC:1.14.99.12|MetaCyc:1.14.99.12-RXN molecular_function owl:Class
GO:0035149 biolink:NamedThing lumen formation, open tracheal system Creation of the central hole of a tube in an open tracheal system through which gases flow. got7fsn_ti tracheal lumen formation biological_process owl:Class
GO:0035148 biolink:NamedThing tube formation Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow. got7fsn_ti tube lumen formation|lumen formation in an anatomical structure biological_process owl:Class
GO:0042428 biolink:NamedThing serotonin metabolic process The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. got7fsn_ti serotonin metabolism biological_process owl:Class
GO:0018020 biolink:NamedThing peptidyl-glutamic acid methylation The addition of a methyl group to a glutamic acid residue in a protein. got7fsn_ti biological_process owl:Class
GO:0048054 biolink:NamedThing R2/R5 cell differentiation The process in which relatively unspecialized cells acquire the specialized features of R2 and R5 photoreceptors. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0080177 biolink:NamedThing plastoglobule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids. got7fsn_ti plastoglobule organisation dhl 2011-04-28T04:13:07Z biological_process owl:Class
GO:0097378 biolink:NamedThing dorsal spinal cord interneuron axon guidance The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord. got7fsn_ti dorsal interneuron axon guidance pr 2012-10-01T10:20:48Z biological_process owl:Class
GO:0120135 biolink:NamedThing distal portion of axoneme The portion of the axoneme that is close to the tip of the cilium. got7fsn_ti distal part of axoneme krc 2018-03-10T01:45:34Z cellular_component owl:Class
GO:0070207 biolink:NamedThing protein homotrimerization The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits. got7fsn_ti protein homotrimer assembly|protein homotrimer biosynthetic process|protein homotrimer formation|protein homotrimer biosynthesis biological_process owl:Class
GO:0047820 biolink:NamedThing D-glutamate cyclase activity Catalysis of the reaction: D-glutamate = 5-oxo-D-proline + H(2)O. got7fsn_ti D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)|D-glutamate hydro-lyase (cyclizing) RHEA:22360|MetaCyc:D-GLUTAMATE-CYCLASE-RXN|EC:4.2.1.48|KEGG_REACTION:R01583 molecular_function owl:Class
GO:0048647 biolink:NamedThing polyphenic determination The process in which individuals that have the potential to develop any of several possible distinct developmental paths have their individual developmental fates determined in response to environmental and/or genetic cues. got7fsn_ti biological_process owl:Class
GO:0035700 biolink:NamedThing astrocyte chemotaxis The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti bf 2011-02-28T03:17:52Z biological_process owl:Class
GO:0047350 biolink:NamedThing glucuronate-1-phosphate uridylyltransferase activity Catalysis of the reaction: 1-phospho-alpha-D-glucuronate + UTP = diphosphate + UDP-alpha-D-glucuronate. got7fsn_ti UTP:1-phospho-alpha-D-glucuronate uridylyltransferase activity|UDP-D-glucuronic acid pyrophosphorylase activity|uridine diphosphoglucuronic pyrophosphorylase activity|UTP:glucuronate-1-phosphate uridylyltransferase activity|UDP-glucuronic acid pyrophosphorylase activity|UDP-glucuronate pyrophosphorylase activity KEGG_REACTION:R01381|RHEA:16325|EC:2.7.7.44|MetaCyc:2.7.7.44-RXN molecular_function owl:Class
GO:0070569 biolink:NamedThing uridylyltransferase activity Catalysis of the transfer of an uridylyl group to an acceptor. got7fsn_ti uridyl transferase activity|uridyltransferase activity mah 2009-04-15T11:06:07Z molecular_function owl:Class
GO:0046691 biolink:NamedThing intracellular canaliculus An apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates. got7fsn_ti canalicular membrane cellular_component owl:Class
GO:0072093 biolink:NamedThing metanephric renal vesicle formation The developmental process pertaining to the initial formation of the metanephros. got7fsn_ti metanephros formation mah 2010-02-10T01:17:11Z biological_process owl:Class
GO:0072033 biolink:NamedThing renal vesicle formation The developmental process pertaining to the initial formation of the renal vesicle from condensed mesenchymal cells. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. got7fsn_ti nephron epithelium formation mah 2010-01-25T02:57:03Z biological_process owl:Class
GO:0035593 biolink:NamedThing positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region. got7fsn_ti positive regulation of Wnt receptor signalling pathway by establishment of Wnt protein localization in extracellular region|positive regulation of Wnt signaling range|positive regulation of Wnt diffusion|positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization in extracellular region|positive regulation of Wnt-activated signaling pathway by establishment of Wnt protein localization to extracellular region|positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localisation in extracellular region|positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region bf 2010-11-09T10:29:44Z biological_process owl:Class
GO:0060406 biolink:NamedThing positive regulation of penile erection Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. got7fsn_ti biological_process owl:Class
GO:0060405 biolink:NamedThing regulation of penile erection Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. got7fsn_ti biological_process owl:Class
GO:0110120 biolink:NamedThing gamma-tubulin complex localization to nuclear side of mitotic spindle pole body Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body. got7fsn_ti kmv 2018-07-27T15:42:46Z biological_process owl:Class
GO:0102560 biolink:NamedThing 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> D-ribofuranose 2,5-bisphosphate + H+. got7fsn_ti phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase EC:3.1.4.57|RHEA:41612|MetaCyc:RXN-14995 molecular_function owl:Class
GO:0047292 biolink:NamedThing trihydroxypterocarpan dimethylallyltransferase activity Catalysis of the reaction: (6AS,11AS)-3,6A,9-trihydroxypterocarpan + dimethylallyl-pyrophosphate = glyceollin + diphosphate. got7fsn_ti dimethylallylpyrophosphate:trihydroxypterocarpan dimethylallyl transferase activity|dimethylallylpyrophosphate:3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity|dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethylallyltransferase activity|dimethylallyl-diphosphate:(6aS,11aS)-3,6a,9-trihydroxypterocarpan dimethyltransferase activity EC:2.5.1.36|MetaCyc:2.5.1.36-RXN molecular_function owl:Class
GO:0042811 biolink:NamedThing pheromone biosynthetic process The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process. got7fsn_ti pheromone biosynthesis|pheromone formation|pheromone anabolism|pheromone synthesis biological_process owl:Class
GO:0042030 biolink:NamedThing ATPase inhibitor activity Binds to and stops, prevents or reduces an ATP hydrolysis activity. got7fsn_ti adenosinetriphosphatase inhibitor https://github.com/geneontology/go-ontology/issues/20955 molecular_function owl:Class
GO:0140678 biolink:NamedThing molecular function inhibitor activity A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21782 pg 2021-07-07T07:24:32Z molecular_function owl:Class
GO:0048749 biolink:NamedThing compound eye development The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye. got7fsn_ti insect-type retina development GO:0007456 biological_process owl:Class
GO:1990688 biolink:NamedThing Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. got7fsn_ti Golgi vesicle fusion with ER-Golgi intermediate compartment membrane|Golgi vesicle fusion with ERGIC membrane bhm 2015-03-12T09:34:21Z biological_process owl:Class
GO:1990668 biolink:NamedThing vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles. got7fsn_ti vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment membrane|vesicle fusion with ER-Golgi intermediate compartment membrane|vesicle fusion with ER-Golgi intermediate compartment (ERGIC) membrane|vesicle fusion with ERGIC membrane bhm 2015-03-02T11:17:32Z biological_process owl:Class
GO:0062051 biolink:NamedThing lipopolysaccharide transport system A protein-containing complex that functions to transport lipopolysaccharide from its site of synthesis at the cytoplasmic membrane across the periplasm to the outer membrane in an ATP-dependent manner. got7fsn_ti dph 2018-06-04T18:44:40Z cellular_component owl:Class
GO:0035226 biolink:NamedThing glutamate-cysteine ligase catalytic subunit binding Binding to the catalytic subunit of glutamate-cysteine ligase. got7fsn_ti molecular_function owl:Class
GO:0043847 biolink:NamedThing DNA polymerase III, clamp loader chi/psi subcomplex A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB). got7fsn_ti DNA polymerase III, DnaX complex, chi/psi subcomplex cellular_component owl:Class
GO:0001171 biolink:NamedThing reverse transcription A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis. got7fsn_ti krc 2011-03-14T03:51:08Z Wikipedia:Reverse_transcription biological_process owl:Class
GO:0006278 biolink:NamedThing RNA-dependent DNA biosynthetic process A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand. got7fsn_ti biological_process owl:Class
GO:0072504 biolink:NamedThing cellular trivalent inorganic cation homeostasis Any process involved in the maintenance of an internal steady state of trivalent cations at the level of a cell. got7fsn_ti Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular divalent inorganic cation homeostasis' ; GO:0072503'). mah 2010-12-16T01:26:43Z biological_process owl:Class
GO:0030003 biolink:NamedThing cellular cation homeostasis Any process involved in the maintenance of an internal steady state of cations at the level of a cell. got7fsn_ti biological_process owl:Class
GO:0150051 biolink:NamedThing postsynaptic Golgi apparatus The network of the Golgi apparatus structures located within the postsynapse. got7fsn_ti Golgi outpost bc 2018-05-08T15:42:56Z cellular_component owl:Class
GO:0005794 biolink:NamedThing Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. got7fsn_ti Golgi|Golgi ribbon|Golgi complex Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. Wikipedia:Golgi_apparatus|NIF_Subcellular:sao451912436 cellular_component owl:Class
GO:0015271 biolink:NamedThing outward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. got7fsn_ti molecular_function owl:Class
GO:0018817 biolink:NamedThing 2-oxo-hept-3-ene-1,7-dioate hydratase activity Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. got7fsn_ti HpaH|2-oxo-hepta-3-ene-1,7-dioate hydratase activity|2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN|RHEA:42072|UM-BBD_reactionID:r0369 molecular_function owl:Class
GO:0033238 biolink:NamedThing regulation of cellular amine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines. got7fsn_ti regulation of amine metabolism biological_process owl:Class
GO:0010945 biolink:NamedThing CoA pyrophosphatase activity Catalysis of the reaction: coenzyme A or its derivatives + H2O = 3',5'-ADP + 4'-phosphopantetheine. got7fsn_ti conezyme A pyrophosphatase activity tb 2009-04-22T02:06:40Z Reactome:R-HSA-6810474|Reactome:R-HSA-6809354 molecular_function owl:Class
GO:0047763 biolink:NamedThing caffeate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate. got7fsn_ti S-adenosyl-L-methionine:caffeic acid-O-methyltransferase activity|S-adenosyl-L-methionine:3,4-dihydroxy-trans-cinnamate 3-O-methyltransferase activity|caffeate 3-O-methyltransferase activity|caffeate methyltransferase activity RHEA:20225|MetaCyc:RXN-1104|EC:2.1.1.68 molecular_function owl:Class
GO:0034904 biolink:NamedThing 5-chloro-2-oxopent-4-enoate hydratase activity Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate. got7fsn_ti UM-BBD_reactionID:r1436 molecular_function owl:Class
GO:0072296 biolink:NamedThing specification of metanephric loop of Henle identity The process in which the loop of Henle of the metanephric nephron acquires its identity. got7fsn_ti specification of metanephric intermediate tubule identity mah 2010-04-09T04:08:05Z biological_process owl:Class
GO:0017130 biolink:NamedThing poly(C) RNA binding Binding to a sequence of cytosine residues in an RNA molecule. got7fsn_ti poly(rC) binding|poly(C) binding molecular_function owl:Class
GO:0004158 biolink:NamedThing dihydroorotate oxidase activity Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate. got7fsn_ti (S)-dihydroorotate:oxygen oxidoreductase activity|4,5-L-dihydroorotate:oxygen oxidoreductase activity RHEA:15441 molecular_function owl:Class
GO:0033563 biolink:NamedThing dorsal/ventral axon guidance The process in which the migration of an axon growth cone is directed to a specific target site along the dorsal-ventral body axis in response to a combination of attractive and repulsive cues. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. got7fsn_ti dorsal/ventral axon pathfinding|dorsal-ventral axon guidance|dorsoventral axon guidance biological_process owl:Class
GO:0090584 biolink:NamedThing protein-phosphocysteine-galactitol-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0140549 biolink:NamedThing spore inner membrane The membrane surrounding the spore core (endospore core) that separates it from its external environment. got7fsn_ti spore membrane https://github.com/geneontology/go-ontology/issues/20359 pg 2020-11-12T10:00:15Z cellular_component owl:Class
GO:0080027 biolink:NamedThing response to herbivore Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a herbivore. got7fsn_ti biological_process owl:Class
GO:0007504 biolink:NamedThing larval fat body development The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life. got7fsn_ti biological_process owl:Class
GO:0031882 biolink:NamedThing type 5 somatostatin receptor binding Binding to a type 5 somatostatin receptor. got7fsn_ti type 5 somatostatin receptor ligand molecular_function owl:Class
GO:0031877 biolink:NamedThing somatostatin receptor binding Binding to a somatostatin receptor. got7fsn_ti somatostatin receptor ligand molecular_function owl:Class
GO:0019445 biolink:NamedThing tyrosine catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate. got7fsn_ti tyrosine breakdown to fumarate|tyrosine degradation to fumarate MetaCyc:TYRFUMCAT-PWY biological_process owl:Class
GO:0030135 biolink:NamedThing coated vesicle Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. got7fsn_ti GO:0005909 NIF_Subcellular:sao1985096626 cellular_component owl:Class
GO:0046151 biolink:NamedThing eye pigment catabolic process The chemical reactions and pathways resulting in the breakdown of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye. got7fsn_ti eye pigment catabolism|eye pigment degradation|eye pigment breakdown biological_process owl:Class
GO:0061315 biolink:NamedThing canonical Wnt signaling pathway involved in positive regulation of cardiac muscle cell proliferation The canonical Wnt signaling pathway that contributes to an expansion of the population of cardiac muscle cells. got7fsn_ti canonical Wnt receptor signaling pathway involved in positive regulation of cardiac muscle cell proliferation|canonical Wnt-activated signaling pathway involved in positive regulation of cardiac muscle cell proliferation|canonical Wnt receptor signalling pathway involved in positive regulation of cardiac muscle cell proliferation dph 2010-09-24T08:53:58Z biological_process owl:Class
GO:0102984 biolink:NamedThing sulfoacetaldehyde dehydrogenase activity Catalysis of the reaction: sulfonatoacetaldehyde + H2O + NAD <=> sulfonatoacetate + NADH + 2 H+. got7fsn_ti MetaCyc:RXN-9592|RHEA:25637|EC:1.2.1.73 molecular_function owl:Class
GO:0005922 biolink:NamedThing connexin complex An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. got7fsn_ti connexon complex|connexon NIF_Subcellular:sao445019788 cellular_component owl:Class
GO:0010102 biolink:NamedThing lateral root morphogenesis The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. got7fsn_ti biological_process owl:Class
GO:0048931 biolink:NamedThing posterior lateral line nerve glial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0048895 biolink:NamedThing lateral line nerve glial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0000485 biolink:NamedThing cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0000483 biolink:NamedThing endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species. got7fsn_ti biological_process owl:Class
GO:0052856 biolink:NamedThing NADHX epimerase activity Catalysis of the reaction: (R)-NADHX = (S)-NADHX. got7fsn_ti RHEA:32215|EC:5.1.99.6 molecular_function owl:Class
GO:0035943 biolink:NamedThing estrone secretion The regulated release of estrone into the circulatory system. got7fsn_ti 3-hydroxy-1,3,5(10)-estratrien-17-one secretion|folliculin secretion bf 2011-07-25T02:18:40Z biological_process owl:Class
GO:0030748 biolink:NamedThing amine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine. got7fsn_ti tryptamine methyltransferase|S-adenosyl-L-methionine:amine N-methyltransferase activity|tryptamine N-methyltransferase activity|arylamine N-methyltransferase activity|nicotine N-methyltransferase activity MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN|EC:2.1.1.49 molecular_function owl:Class
GO:0018240 biolink:NamedThing protein S-linked glycosylation via cysteine The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine. got7fsn_ti protein amino acid S-linked glycosylation via cysteine RESID:AA0152 biological_process owl:Class
GO:0051692 biolink:NamedThing cellular oligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells. got7fsn_ti cellular oligosaccharide breakdown|cellular oligosaccharide degradation|cellular oligosaccharide catabolism biological_process owl:Class
GO:0051691 biolink:NamedThing cellular oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages, as carried out by individual cells. got7fsn_ti cellular oligosaccharide metabolism biological_process owl:Class
GO:0043905 biolink:NamedThing Ser-tRNA(Thr) hydrolase activity Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr). got7fsn_ti Ser-tRNAThr hydrolase activity EC:3.1.1.- molecular_function owl:Class
GO:0097019 biolink:NamedThing neurotransmitter receptor catabolic process The chemical reactions and pathways resulting in the breakdown of neurotransmitter receptors. got7fsn_ti neurotransmitter receptor catabolism|neurotransmitter receptor breakdown|neurotransmitter receptor degradation pr 2011-03-23T04:16:11Z biological_process owl:Class
GO:0032454 biolink:NamedThing histone H3-methyl-lysine-9 demethylase activity Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein. got7fsn_ti H3K49 demethylase activity|histone demethylase activity (H3-K9 specific) https://github.com/geneontology/go-ontology/issues/21089 Reactome:R-HSA-9011985|Reactome:R-HSA-9011949|Reactome:R-HSA-997263 molecular_function owl:Class
GO:0005586 biolink:NamedThing collagen type III trimer A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils. got7fsn_ti cellular_component owl:Class
GO:0033593 biolink:NamedThing BRCA2-MAGE-D1 complex A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth. got7fsn_ti cellular_component owl:Class
GO:0090538 biolink:NamedThing peptide pheromone secretion The regulated release of a peptide pheromone from a cell. got7fsn_ti tb 2013-02-11T15:38:29Z biological_process owl:Class
GO:0030920 biolink:NamedThing peptidyl-serine acetylation The acetylation of peptidyl-serine. got7fsn_ti biological_process owl:Class
GO:0043652 biolink:NamedThing engulfment of apoptotic cell The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte. got7fsn_ti engulfment of cell corpse|engulfment of apoptotic cell corpse This term should be used to annotate gene products from the engulfing cell that facilitate phagocytosis of apoptotic cells. It should not be mistaken with GO:0070782 'phosphatidylserine exposure on apoptotic cell surface', a process occurring in apoptotic cells that acts as a signal for engulfing cells. If gene products involved in such instances of phosphatidylserine exposure are shown to have a positive effect on engulfment, they may be annotated to GO:1901076 'positive regulation of engulfment of apoptotic cell'. biological_process owl:Class
GO:0006911 biolink:NamedThing phagocytosis, engulfment The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis. got7fsn_ti phagosome biosynthesis|phagosome formation biological_process owl:Class
GO:0018226 biolink:NamedThing peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic. got7fsn_ti peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine|peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine RESID:AA0102 biological_process owl:Class
GO:0005295 biolink:NamedThing neutral amino acid:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in). got7fsn_ti neutral amino acid-sodium cotransporter|sodium/neutral amino acid transporter GO:0005282 molecular_function owl:Class
GO:0046682 biolink:NamedThing response to cyclodiene Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclodiene stimulus. A cyclodiene is any organic insecticide (as dieldrin or chlordane) with a chlorinated methylene group forming a bridge across a 6-membered carbon ring. got7fsn_ti cyclodiene susceptibility/resistance|cyclodiene resistance biological_process owl:Class
GO:0017085 biolink:NamedThing response to insecticide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects. got7fsn_ti insecticide susceptibility/resistance|insecticide resistance biological_process owl:Class
GO:0051132 biolink:NamedThing NK T cell activation The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti NKT cell activation|NK T-lymphocyte activation|NK T lymphocyte activation|natural T cell activation|NT cell activation|NK T-cell activation|natural killer T cell activation Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments. biological_process owl:Class
GO:0035729 biolink:NamedThing cellular response to hepatocyte growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. got7fsn_ti cellular response to HGF stimulus bf 2011-03-10T03:04:19Z biological_process owl:Class
GO:0035728 biolink:NamedThing response to hepatocyte growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. got7fsn_ti response to HGF stimulus|response to hepatocyte growth factor stimulus bf 2011-03-10T03:02:47Z biological_process owl:Class
GO:0050574 biolink:NamedThing 2-(R)-hydroxypropyl-CoM dehydrogenase activity Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH. got7fsn_ti 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase activity|2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity RHEA:13249|EC:1.1.1.268|MetaCyc:1.1.1.268-RXN|KEGG_REACTION:R05689|UM-BBD_reactionID:r0852 molecular_function owl:Class
GO:0043716 biolink:NamedThing 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene. got7fsn_ti 2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity|HK-MTPenyl-1-P phosphatase activity MetaCyc:R83-RXN|RHEA:14481|KEGG_REACTION:R07394 molecular_function owl:Class
GO:0004181 biolink:NamedThing metallocarboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 MetaCyc:CARBOXYPEPTIDASE-H-RXN|Reactome:R-HSA-9023163|MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN|EC:3.4.17.6|MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN|EC:3.4.17.4|Reactome:R-HSA-2028294|EC:3.4.17.21|MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN|MetaCyc:CARBOXYPEPTIDASE-B-RXN|EC:3.4.17.22|EC:3.4.17.-|EC:3.4.17.10|Reactome:R-HSA-8955712|EC:3.4.17.1|MetaCyc:CARBOXYPEPTIDASE-A-RXN|MetaCyc:3.4.17.17-RXN|Reactome:R-HSA-2022378|Reactome:R-HSA-9023159|MetaCyc:3.4.17.22-RXN|EC:3.4.17.17|Reactome:R-HSA-8852809|EC:3.4.17.3|Reactome:R-HSA-8866105|Reactome:R-HSA-2022379|EC:3.4.17.2 molecular_function owl:Class
GO:0004180 biolink:NamedThing carboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 MetaCyc:3.4.17.11-RXN|EC:3.4.17.11|Reactome:R-HSA-1247910|RHEA:28783 molecular_function owl:Class
GO:0008401 biolink:NamedThing retinoic acid 4-hydroxylase activity Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. got7fsn_ti cytochrome P450 CYP261 Reactome:R-HSA-5602050|Reactome:R-HSA-211923|Reactome:R-HSA-211874|Reactome:R-HSA-212007|Reactome:R-HSA-5362525|Reactome:R-HSA-5602063 molecular_function owl:Class
GO:0090671 biolink:NamedThing telomerase RNA localization to Cajal body A process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body. got7fsn_ti tb 2015-12-17T14:06:21Z biological_process owl:Class
GO:0010147 biolink:NamedThing fructan catabolic process The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues. got7fsn_ti fructan degradation|fructan catabolism|fructan breakdown|levan catabolism|levan catabolic process MetaCyc:PWY-862 biological_process owl:Class
GO:0070093 biolink:NamedThing negative regulation of glucagon secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon. got7fsn_ti down regulation of glucagon secretion|inhibition of glucagon secretion|downregulation of glucagon secretion|down-regulation of glucagon secretion biological_process owl:Class
GO:0045157 biolink:NamedThing electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis. got7fsn_ti cytochrome molecular_function owl:Class
GO:0060073 biolink:NamedThing micturition The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body. got7fsn_ti urination|urine voiding Wikipedia:Urination biological_process owl:Class
GO:0002017 biolink:NamedThing regulation of blood volume by renal aldosterone The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume. got7fsn_ti renal regulation of blood volume by aldosterone|aldosterone mediated control of body fluids|aldosterone mediated regulation of blood volume biological_process owl:Class
GO:0001977 biolink:NamedThing renal system process involved in regulation of blood volume A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system. got7fsn_ti renal blood volume control of blood pressure|renal regulation of blood volume biological_process owl:Class
GO:0002384 biolink:NamedThing hepatic immune response An immune response taking place in the liver. got7fsn_ti biological_process owl:Class
GO:0002251 biolink:NamedThing organ or tissue specific immune response An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues. got7fsn_ti immune response in organ or tissue biological_process owl:Class
GO:0004513 biolink:NamedThing neolactotetraosylceramide alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide. got7fsn_ti cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity|SAT-3|CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity|sialyltransferase 3 EC:2.4.99.10|MetaCyc:2.4.99.10-RXN|RHEA:18913 molecular_function owl:Class
GO:0010429 biolink:NamedThing methyl-CpNpN binding Binding to a methylated cytosine/unspecified/unspecified trinucleotide. got7fsn_ti molecular_function owl:Class
GO:0000166 biolink:NamedThing nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. got7fsn_ti molecular_function owl:Class
GO:0016886 biolink:NamedThing ligase activity, forming phosphoric ester bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti EC:6.5.-.- molecular_function owl:Class
GO:0016874 biolink:NamedThing ligase activity Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. got7fsn_ti synthetase activity https://github.com/geneontology/go-ontology/issues/19380 EC:6.-.-.- molecular_function owl:Class
GO:0001064 biolink:NamedThing single subunit type RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti T3/T7 type RNA polymerase activity krc 2010-10-19T03:47:56Z molecular_function owl:Class
GO:0003899 biolink:NamedThing DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti DNA-directed RNA polymerase III activity|DNA-dependent ribonucleate nucleotidyltransferase activity|transcriptase|RNA polymerase II activity|DNA-dependent RNA nucleotidyltransferase activity|DNA-directed RNA polymerase activity|DNA-dependent RNA polymerase activity|C RNA formation factors|DNA-directed RNA polymerase I activity|deoxyribonucleic acid-dependent ribonucleic acid polymerase activity|RNA polymerase III activity|nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity|DNA-directed RNA polymerase II activity|RNA polymerase I activity|C ribonucleic acid formation factors|RNA nucleotidyltransferase (DNA-directed) activity GO:0000129 Reactome:R-HSA-174425|Reactome:R-HSA-75873|Reactome:R-HSA-167136|Reactome:R-HSA-6781824|Reactome:R-HSA-167115|Reactome:R-HSA-167117|Reactome:R-HSA-75869|EC:2.7.7.6|Reactome:R-HSA-5601926|Reactome:R-HSA-203901|Reactome:R-HSA-9697084|Reactome:R-HSA-111264|Reactome:R-HSA-9670149|Reactome:R-HSA-427366|MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN|Reactome:R-HSA-167113|Reactome:R-HSA-76576|Reactome:R-HSA-9697085|Reactome:R-HSA-68913|Reactome:R-HSA-74986|Reactome:R-HSA-75850|Reactome:R-HSA-167121 molecular_function owl:Class
GO:0061040 biolink:NamedThing female gonad morphogenesis The process in which a female gonad is generated and organized. got7fsn_ti ovary morphogenesis dph 2010-02-22T11:29:28Z biological_process owl:Class
GO:0035262 biolink:NamedThing gonad morphogenesis The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals. got7fsn_ti biological_process owl:Class
GO:0071693 biolink:NamedThing protein transport within extracellular region The directed movement of proteins in the extracellular region, by means of some agent such as a transporter or pore. got7fsn_ti mah 2010-02-25T04:02:35Z biological_process owl:Class
GO:0001742 biolink:NamedThing oenocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments. got7fsn_ti oenocyte cell differentiation biological_process owl:Class
GO:0098755 biolink:NamedThing maintenance of seed dormancy by absisic acid The process by which seed dormancy is maintained by the presence of absisic acid. got7fsn_ti biological_process owl:Class
GO:0010231 biolink:NamedThing maintenance of seed dormancy Any process that maintains a seed in a dormant state. got7fsn_ti biological_process owl:Class
GO:0031120 biolink:NamedThing snRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an snRNA molecule. got7fsn_ti biological_process owl:Class
GO:0050514 biolink:NamedThing homospermidine synthase (spermidine-specific) activity Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine. got7fsn_ti spermidine:putrescine 4-aminobutyltransferase (propane-1,3-diamine-forming) MetaCyc:2.5.1.45-RXN|RHEA:11236|EC:2.5.1.45 molecular_function owl:Class
GO:0102928 biolink:NamedThing beta-solanine rhamnosyltransferase activity Catalysis of the reaction: beta-solanine + UDP-L-rhamnose = solanine + UDP. got7fsn_ti MetaCyc:RXN-8884 molecular_function owl:Class
GO:0019148 biolink:NamedThing D-cysteine desulfhydrase activity Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate. got7fsn_ti D-cysteine sulfide-lyase (deaminating)|D-cysteine sulfide-lyase (deaminating; pyruvate-forming)|D-cysteine lyase activity MetaCyc:DCYSDESULF-RXN|RHEA:11268|EC:4.4.1.15 molecular_function owl:Class
GO:0018361 biolink:NamedThing peptidyl-glutamine 2-methylation The methylation of glutamine to form 2-methyl-L-glutamine. got7fsn_ti RESID:AA0273 biological_process owl:Class
GO:0047996 biolink:NamedThing hydroxyphytanate oxidase activity Catalysis of the reaction: (2S)-2-hydroxyphytanate + O(2) = 2-oxophytanate + H(2)O(2). got7fsn_ti L-2-hydroxyphytanate:oxygen 2-oxidoreductase KEGG_REACTION:R07151|MetaCyc:HYDROXYPHYTANATE-OXIDASE-RXN|EC:1.1.3.27|RHEA:21680 molecular_function owl:Class
GO:0002136 biolink:NamedThing tRNA wobble base lysidine biosynthesis The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine. got7fsn_ti Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP. biological_process owl:Class
GO:0002101 biolink:NamedThing tRNA wobble cytosine modification The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified. got7fsn_ti biological_process owl:Class
GO:0035188 biolink:NamedThing hatching The emergence of an immature organism from a protective structure. got7fsn_ti biological_process owl:Class
GO:0071684 biolink:NamedThing organism emergence from protective structure The developmental process in which an organism emerges from a surrounding protective structure such as an egg or pupa case. got7fsn_ti mah 2010-02-19T04:23:55Z biological_process owl:Class
GO:0035447 biolink:NamedThing mycothiol synthase activity Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol. got7fsn_ti acetyl-CoA:Cys-GlcN-Ins acetyltransferase bf 2010-04-14T11:40:26Z MetaCyc:MONOMER-9684 molecular_function owl:Class
GO:0140221 biolink:NamedThing pathogen-containing vacuole membrane Host-derived membrane of a pathogen-containing vacuole. got7fsn_ti pathogen inclusion membrane|pathogen-containing compartment membrane https://github.com/geneontology/go-ontology/issues/15580 pg 2018-04-20T06:18:25Z cellular_component owl:Class
GO:0036392 biolink:NamedThing chemokine (C-C motif) ligand 20 production The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti C-C motif chemokine 20 production|CCL-20 production|CCL20 production bf 2013-06-17T14:42:07Z biological_process owl:Class
GO:0046315 biolink:NamedThing phosphocreatine catabolic process The chemical reactions and pathways resulting in the breakdown of phosphocreatine, a phosphagen of creatine which is synthesized and broken down by creatine phosphokinase. got7fsn_ti phosphocreatine breakdown|phosphocreatine catabolism|phosphocreatine degradation biological_process owl:Class
GO:0046406 biolink:NamedThing magnesium protoporphyrin IX methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + magnesium protoporphyrin IX = S-adenosyl-L-homocysteine + H(+) + magnesium protoporphyrin IX 13-monomethyl ester. got7fsn_ti (-)-S-adenosyl-L-methionine:magnesium-protoporphyrin IX methyltransferase activity|S-adenosyl-L-methionine:magnesium-protoporphyrin O-methyltransferase activity|S-adenosyl-L-methionine:Mg protoporphyrin methyltransferase activity|magnesium-protoporphyrin O-methyltransferase activity|S-adenosylmethionine-magnesium protoporphyrin methyltransferase activity|S-adenosyl-L-methionine:magnesium-protoporphyrin-IX O-methyltransferase activity|Mg-protoporphyrin IX methyltransferase activity|S-adenosylmethioninemagnesium protoporphyrin methyltransferase activity RHEA:17809|MetaCyc:RXN-MG-PROTOPORPHYRIN-METHYLESTER-SYN|KEGG_REACTION:R04237|EC:2.1.1.11 molecular_function owl:Class
GO:0046701 biolink:NamedThing insecticide catabolic process The chemical reactions and pathways resulting in the breakdown of insecticides, chemicals used to kill insects. got7fsn_ti insecticide catabolism|insecticide breakdown|insecticide degradation biological_process owl:Class
GO:0035801 biolink:NamedThing adrenal cortex development The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens). got7fsn_ti adrenal gland cortex development bf 2011-04-18T10:25:39Z biological_process owl:Class
GO:0097137 biolink:NamedThing BAD-BCL-xl complex A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:36:06Z cellular_component owl:Class
GO:0051932 biolink:NamedThing synaptic transmission, GABAergic The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. got7fsn_ti GABAergic synaptic transmission|synaptic transmission, gamma-aminobutyric acid mediated|synaptic transmission, gamma-aminobutyric acid-ergic|synaptic transmission, GABA mediated biological_process owl:Class
GO:0018339 biolink:NamedThing peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12. got7fsn_ti peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid|peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid|peptidyl-aspartic acid methylthiolation|peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid RESID:AA0232 biological_process owl:Class
GO:0031943 biolink:NamedThing regulation of glucocorticoid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. got7fsn_ti regulation of glucocorticoid metabolism biological_process owl:Class
GO:0048497 biolink:NamedThing maintenance of floral organ identity The process in which the identity of a floral organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0047083 biolink:NamedThing 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + trans-5-O-(4-coumaroyl)-D-quinate = H2O + NADP+ + trans-5-O-caffeoyl-D-quinate. got7fsn_ti trans-5-O-(4-coumaroyl)-D-quinate,NADPH:oxygen oxidoreductase (3'-hydroxylating)|coumaroylquinate(coumaroylshikimate) 3'-monooxygenase activity|5-O-(4-coumaroyl)-D-quinate/shikimate 3'-hydroxylase activity EC:1.14.14.96|MetaCyc:1.14.13.36-RXN|RHEA:16265 molecular_function owl:Class
GO:0036320 biolink:NamedThing mating-type P-factor pheromone receptor activity Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus. got7fsn_ti P-factor mating pheromone receptor activity|P-factor receptor activity bf 2012-08-30T16:55:30Z molecular_function owl:Class
GO:0071517 biolink:NamedThing maintenance of imprinting at mating-type locus Any process involved in preserving the structure of a stable single-strand DNA lesion that triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication. got7fsn_ti mating type determination, maintenance of imprinting mah 2010-01-06T01:17:05Z biological_process owl:Class
GO:0072283 biolink:NamedThing metanephric renal vesicle morphogenesis The process in which the anatomical structures of the metanephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells. got7fsn_ti mah 2010-04-01T03:28:00Z biological_process owl:Class
GO:0072077 biolink:NamedThing renal vesicle morphogenesis The process in which the anatomical structures of the renal vesicle are generated and organized. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. got7fsn_ti mah 2010-02-01T02:21:06Z biological_process owl:Class
GO:0047596 biolink:NamedThing 6-methylsalicylate decarboxylase activity Catalysis of the reaction: 6-methylsalicylate + H(+) = 3-cresol + CO(2). got7fsn_ti 6-MSA decarboxylase activity|6-methylsalicylate carboxy-lyase (3-cresol-forming)|6-methylsalicylic acid (2,6-cresotic acid) decarboxylase activity|6-methylsalicylate carboxy-lyase activity RHEA:23112|EC:4.1.1.52|MetaCyc:6-METHYLSALICYLATE-DECARBOXYLASE-RXN|KEGG_REACTION:R03567 molecular_function owl:Class
GO:0034703 biolink:NamedThing cation channel complex An ion channel complex through which cations pass. got7fsn_ti cellular_component owl:Class
GO:0097436 biolink:NamedThing entry into dormancy The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. got7fsn_ti induction of dormancy pr 2012-12-05T14:55:49Z biological_process owl:Class
GO:0102555 biolink:NamedThing octanoyl transferase activity (acting on glycine-cleavage complex H protein) Catalysis of the reaction: [glycine cleavage system lipoyl-carrier protein]-L-lysine + octanoyl-ACP = H+ + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + a holo-[acyl-carrier protein]. got7fsn_ti EC:2.3.1.181|MetaCyc:RXN-14966|RHEA:17665 molecular_function owl:Class
GO:0016415 biolink:NamedThing octanoyltransferase activity Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. got7fsn_ti EC:2.3.1.181 molecular_function owl:Class
GO:0014834 biolink:NamedThing skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells. got7fsn_ti satellite cell compartment self-renewal involved in skeletal muscle regeneration|satellite cell population maintenance|satellite cell self-renewal biological_process owl:Class
GO:0098727 biolink:NamedThing maintenance of cell number Any process by which the numbers of cells of a particular type or in a tissue are maintained. got7fsn_ti biological_process owl:Class
GO:0004589 biolink:NamedThing orotate reductase (NADH) activity Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate. got7fsn_ti (S)-dihydroorotate:NAD+ oxidoreductase activity RHEA:13513|KEGG_REACTION:R01869|MetaCyc:OROTATE-REDUCTASE-NADH-RXN|EC:1.3.1.14 molecular_function owl:Class
GO:0019607 biolink:NamedThing phenylethylamine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. got7fsn_ti phenylethylamine degradation|phenylethylamine catabolism|phenylethylamine breakdown MetaCyc:2PHENDEG-PWY biological_process owl:Class
GO:0048877 biolink:NamedThing homeostasis of number of retina cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina. got7fsn_ti biological_process owl:Class
GO:0051239 biolink:NamedThing regulation of multicellular organismal process Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs. got7fsn_ti biological_process owl:Class
GO:0071075 biolink:NamedThing CUGBP1-eIF2 complex A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation. got7fsn_ti mah 2009-11-06T01:43:30Z cellular_component owl:Class
GO:0031719 biolink:NamedThing type 2 cannabinoid receptor binding Binding to a type 2 cannabinoid receptor. got7fsn_ti type 2 cannabinoid receptor ligand molecular_function owl:Class
GO:0031717 biolink:NamedThing cannabinoid receptor binding Binding to a cannabinoid receptor. got7fsn_ti cannabinoid receptor ligand molecular_function owl:Class
GO:0060024 biolink:NamedThing rhythmic synaptic transmission Any process involved in the generation of rhythmic, synchronous synaptic inputs in a neural circuit. got7fsn_ti biological_process owl:Class
GO:0050804 biolink:NamedThing modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. got7fsn_ti regulation of synaptic transmission|modulation of synaptic transmission|regulation of chemical synaptic transmission biological_process owl:Class
GO:0070257 biolink:NamedThing positive regulation of mucus secretion Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. got7fsn_ti positive regulation of mucus production biological_process owl:Class
GO:0098855 biolink:NamedThing HCN channel complex A cation ion channel with a preference for K+ over Na+ ions, which is activated by membrane hyperpolarization, and consists of a tetramer of HCN family members. Some members of this family (HCN1, HCN2 and HCN4) are also activated when cAMP binds to their cyclic nucleotide binding domain (CNBD). Channel complexes of this family play an important role in the control of pacemaker activity in the heart. got7fsn_ti HCN1 channel complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel complex|potassium/sodium hyperpolarization-activated channel 3 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 tetramer|K/Na hyperpolarization-activated cyclic nucleotide-gated channel 2 complex|HCN2 channel complex|HCN4 channel complex|HCN3 channel complex|K/Na hyperpolarization-activated cyclic nucleotide-gated channel 4 complex|K/Na hyperpolarization-activated channel 3 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 tetramer|K/Na hyperpolarization-activated cyclic nucleotide-gated channel 1 complex|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 complex|K/Na hyperpolarization-activated cyclic nucleotide-gated channel complex GO:1990746|GO:1990759 cellular_component owl:Class
GO:0097087 biolink:NamedThing interleukin-17A production The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-17A biosynthetic process|IL-17A production bc 2011-06-23T11:31:10Z GO:0150154 biological_process owl:Class
GO:0097352 biolink:NamedThing autophagosome maturation Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling. got7fsn_ti autophagic vacuole fusion|autophagosome fusion|autophagic vacuole maturation pr 2012-06-28T03:12:18Z GO:0000046 biological_process owl:Class
GO:0061779 biolink:NamedThing Tapasin-ERp57 complex Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role. got7fsn_ti dph 2016-08-05T12:12:08Z cellular_component owl:Class
GO:0009383 biolink:NamedThing rRNA (cytosine-C5-)-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA. got7fsn_ti rRNA m5C967 methyltransferase activity|rRNA (cytosine-C5-967)-methyltransferase activity Reactome:R-HSA-6793057|Reactome:R-HSA-6790944 molecular_function owl:Class
GO:0003028 biolink:NamedThing regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. got7fsn_ti aortic body chemoreceptor regulation of systemic arterial blood pressure|aortic body chemoreceptor response to lowering of systemic arterial blood pressure|regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling biological_process owl:Class
GO:0001979 biolink:NamedThing regulation of systemic arterial blood pressure by chemoreceptor signaling The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. got7fsn_ti chemoreceptor control of blood pressure|regulation of systemic arterial blood pressure by chemoreceptor signalling|chemoreceptor regulation of systemic arterial blood pressure biological_process owl:Class
GO:0010376 biolink:NamedThing stomatal complex formation The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells. got7fsn_ti biological_process owl:Class
GO:0009020 biolink:NamedThing tRNA (guanosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine. got7fsn_ti tRNA guanosine 2'-methyltransferase activity|transfer ribonucleate guanosine 2'-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity|tRNA (Gm18) methyltransferase activity|S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity|tRNA (guanosine 2')-methyltransferase activity|tRNA (Gm18) 2'-O-methyltransferase activity|tRNA guanosine-2'-O-methyltransferase activity RHEA:20077|MetaCyc:2.1.1.34-RXN|EC:2.1.1.34|Reactome:R-HSA-9024161 molecular_function owl:Class
GO:0050247 biolink:NamedThing raucaffricine beta-glucosidase activity Catalysis of the reaction: H(2)O + raucaffricine = D-glucose + vomilenine. got7fsn_ti raucaffricine beta-D-glucohydrolase activity|raucaffricine b-glucosidase activity|raucaffricine glucosidase activity|raucaffricine beta-D-glucosidase activity EC:3.2.1.125|RHEA:14557|MetaCyc:RAUCAFFRICINE-BETA-GLUCOSIDASE-RXN|KEGG_REACTION:R03703 molecular_function owl:Class
GO:0033608 biolink:NamedThing formyl-CoA transferase activity Catalysis of the reaction: formyl-CoA + oxalate = formate + oxalyl-CoA. got7fsn_ti formyl-coenzyme A transferase activity|formyl-CoA:oxalate CoA-transferase activity|formyl-CoA oxalate CoA-transferase activity KEGG_REACTION:R07290|EC:2.8.3.16|RHEA:16545|MetaCyc:RXN0-1382 molecular_function owl:Class
GO:0005161 biolink:NamedThing platelet-derived growth factor receptor binding Binding to a platelet-derived growth factor receptor. got7fsn_ti platelet-derived growth factor|PDGFR binding|platelet-derived growth factor receptor ligand|PDGF receptor binding|PDGF molecular_function owl:Class
GO:0061555 biolink:NamedThing ganglion structural organization The process that contributes to creating the structural organization of a ganglion. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti ganglia structural organization dph 2013-07-10T08:54:39Z biological_process owl:Class
GO:0070633 biolink:NamedThing transepithelial transport The directed movement of a substance from one side of an epithelium to the other. got7fsn_ti mah 2009-05-06T03:31:02Z biological_process owl:Class
GO:0019414 biolink:NamedThing aerobic respiration, using sulfur or sulfate as electron donor An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized. got7fsn_ti aerobic respiration, using sulphur or sulphate as electron donor biological_process owl:Class
GO:0140059 biolink:NamedThing dendrite arborization The process in which the anatomical structures of a dendritic tree are generated and organized into dendritic branches. got7fsn_ti pg 2017-07-12T15:12:07Z biological_process owl:Class
GO:0048813 biolink:NamedThing dendrite morphogenesis The process in which the anatomical structures of a dendrite are generated and organized. got7fsn_ti biological_process owl:Class
GO:0034800 biolink:NamedThing trinitrophenol dihydride denitratase activity Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP. got7fsn_ti TNP dihydride denitratase activity|2,4,6-trinitrophenol dihydride denitratase activity EC:1.7.99.-|UM-BBD_reactionID:r1067 molecular_function owl:Class
GO:0150057 biolink:NamedThing amylin receptor complex 2 A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 2. Amylin receptor complex 2 (AMY2) also serves as a receptor for adrenomedullin (AM/ADM). got7fsn_ti AMY2 complex bc 2018-06-21T10:51:35Z cellular_component owl:Class
GO:1903440 biolink:NamedThing amylin receptor complex A protein complex which is capable of amylin receptor activity. got7fsn_ti pr 2014-09-16T13:25:20Z cellular_component owl:Class
GO:0004699 biolink:NamedThing calcium-independent protein kinase C activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium. got7fsn_ti calcium-independent PKC activity|novel protein kinase C activity Reactome:R-HSA-5607740 molecular_function owl:Class
GO:0004697 biolink:NamedThing protein kinase C activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. got7fsn_ti PKC activity|PKCgamma|nPKCtheta|cPKC|nPKCepsilon|Pkc1p|cPKCbeta|diacylglycerol-activated phospholipid-dependent protein kinase C activity|PKCbeta|STK24|PKC|cPKCgamma|PKCdelta|nPKCeta|nPKCdelta|PKCzeta|PKCepsilon|nPKC|ATP:protein phosphotransferase (diacylglycerol-dependent) activity|protein kinase Cepsilon activity|cPKCalpha|PKCalpha|diacylglycerol-activated phospholipid-dependent PKC activity GO:0004701 Reactome:R-HSA-2179413|Reactome:R-HSA-5218823|Reactome:R-HSA-5623667|Reactome:R-HSA-5229194|Reactome:R-HSA-5671749|Reactome:R-HSA-5138432|Reactome:R-HSA-2730863|Reactome:R-HSA-5218805|Reactome:R-HSA-927889|EC:2.7.11.13|Reactome:R-HSA-9010681|Reactome:R-HSA-193703|Reactome:R-HSA-450533|Reactome:R-HSA-8934446|Reactome:R-HSA-9021357|Reactome:R-HSA-751040|MetaCyc:2.7.11.13-RXN|Reactome:R-HSA-374664|Reactome:R-HSA-909552|Reactome:R-HSA-450550|Reactome:R-HSA-9626817|Reactome:R-HSA-198314|Reactome:R-HSA-1433508|Reactome:R-HSA-9632858|Reactome:R-HSA-74615|Reactome:R-HSA-5625784|Reactome:R-HSA-429698 molecular_function owl:Class
GO:0090096 biolink:NamedThing positive regulation of metanephric cap mesenchymal cell proliferation Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. got7fsn_ti tb 2009-11-13T10:40:32Z biological_process owl:Class
GO:0090184 biolink:NamedThing positive regulation of kidney development Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti positive regulation of nephrogenesis tb 2009-12-18T10:52:01Z biological_process owl:Class
GO:0010154 biolink:NamedThing fruit development The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant. got7fsn_ti biological_process owl:Class
GO:0035237 biolink:NamedThing corazonin receptor activity Combining with the neuropeptide corazonin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0000829 biolink:NamedThing inositol heptakisphosphate kinase activity Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown. got7fsn_ti Reactome:R-HSA-1855182|Reactome:R-HSA-1855194|Reactome:R-HSA-1855157 molecular_function owl:Class
GO:0006853 biolink:NamedThing carnitine shuttle The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine. got7fsn_ti See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. Wikipedia:Carnitine#Role_in_fatty_acid_metabolism biological_process owl:Class
GO:0033227 biolink:NamedThing dsRNA transport The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0060893 biolink:NamedThing limb granular cell fate specification The process in which a cell becomes capable of differentiating autonomously into an limb granular cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti dph 2009-08-13T01:44:14Z biological_process owl:Class
GO:0097344 biolink:NamedThing Rix1 complex A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes. got7fsn_ti IPI complex pr 2012-06-18T01:38:49Z cellular_component owl:Class
GO:0070193 biolink:NamedThing synaptonemal complex organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis. got7fsn_ti synaptonemal complex organisation biological_process owl:Class
GO:0052898 biolink:NamedThing N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2). got7fsn_ti RHEA:25864|EC:1.5.3.15 molecular_function owl:Class
GO:0045010 biolink:NamedThing actin nucleation The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament. got7fsn_ti actin filament nucleation biological_process owl:Class
GO:0001184 biolink:NamedThing promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. got7fsn_ti krc 2011-08-15T04:03:52Z biological_process owl:Class
GO:0001182 biolink:NamedThing promoter clearance from RNA polymerase I promoter Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. got7fsn_ti krc 2011-08-15T03:49:28Z biological_process owl:Class
GO:0047911 biolink:NamedThing galacturan 1,4-alpha-galacturonidase activity Catalysis of the reaction: [(1->4)-alpha-D-galacturonide](n) + H2O = [(1->4)-alpha-D-galacturonide](n-1) + D-galacturonate. got7fsn_ti poly(1,4-alpha-D-galacturonide) galacturonohydrolase activity|exo-D-galacturonanase activity|exo-D-galacturonase activity|exopoly-D-galacturonase activity|exo-polygalacturonase activity|galacturan alpha-1,4-galacturonidase activity|poly(galacturonate) hydrolase activity|exopolygalacturonase activity EC:3.2.1.67|RHEA:14117|MetaCyc:GALACTURAN-14-ALPHA-GALACTURONIDASE-RXN molecular_function owl:Class
GO:0032918 biolink:NamedThing spermidine acetylation The modification of spermidine by addition of acetyl groups. got7fsn_ti biological_process owl:Class
GO:0008216 biolink:NamedThing spermidine metabolic process The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane. got7fsn_ti spermidine metabolism biological_process owl:Class
GO:1990789 biolink:NamedThing thyroid gland epithelial cell proliferation The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population. got7fsn_ti Hurthle cell proliferation|thyroid follicular cell proliferation sl 2015-07-02T18:50:01Z biological_process owl:Class
GO:0031964 biolink:NamedThing beta-alanyl-histamine hydrolase activity Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine. got7fsn_ti carcinine hydrolase activity molecular_function owl:Class
GO:0097545 biolink:NamedThing axonemal outer doublet Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium. got7fsn_ti axoneme outer doublet|outer doublet|outer-doublet microtubules pr 2013-12-12T11:19:29Z cellular_component owl:Class
GO:0044092 biolink:NamedThing negative regulation of molecular function Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. got7fsn_ti jl 2009-04-21T04:07:27Z biological_process owl:Class
GO:0002750 biolink:NamedThing antigen processing and presentation following macropinocytosis Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis. got7fsn_ti biological_process owl:Class
GO:0038113 biolink:NamedThing interleukin-9-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-9-mediated signalling pathway|IL-9-mediated signaling pathway bf 2012-03-22T10:20:33Z biological_process owl:Class
GO:0098688 biolink:NamedThing parallel fiber to Purkinje cell synapse An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. got7fsn_ti dos 2017-02-21T18:32:05Z cellular_component owl:Class
GO:0061143 biolink:NamedThing alveolar primary septum development The progression of a primary alveolar septum over time, from its formation to the mature structure. A primary alveolar septum is a specialized epithelium that surrounds the saccule as it forms. got7fsn_ti dph 2010-05-25T10:21:27Z biological_process owl:Class
GO:0060428 biolink:NamedThing lung epithelium development The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung. got7fsn_ti pulmonary epithelium development biological_process owl:Class
GO:0048939 biolink:NamedThing anterior lateral line nerve glial cell development The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0048937 biolink:NamedThing lateral line nerve glial cell development The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:2000294 biolink:NamedThing positive regulation of defecation Any process that activates or increases the frequency, rate or extent of defecation. got7fsn_ti bf 2010-12-21T09:23:16Z biological_process owl:Class
GO:0060292 biolink:NamedThing long-term synaptic depression A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. got7fsn_ti LTD|long term depression|long term synaptic depression biological_process owl:Class
GO:0048167 biolink:NamedThing regulation of synaptic plasticity A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. got7fsn_ti Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:0009017 biolink:NamedThing succinylglutamate desuccinylase activity Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate. got7fsn_ti AstE|N-succinyl-L-glutamate amidohydrolase activity|N2-succinylglutamate desuccinylase activity|SGDS MetaCyc:SUCCGLUDESUCC-RXN|KEGG_REACTION:R00411|RHEA:15169|EC:3.5.1.96 molecular_function owl:Class
GO:0047664 biolink:NamedThing aminoimidazolase activity Catalysis of the reaction:4-aminoimidazole + H20 = imidazol-4-one + NH(3). got7fsn_ti 4-aminoimidazole hydrolase activity|4-aminoimidazole aminohydrolase activity EC:3.5.4.8|RHEA:22348|MetaCyc:R13-RXN molecular_function owl:Class
GO:0043153 biolink:NamedThing entrainment of circadian clock by photoperiod The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night). got7fsn_ti photoentrainment of circadian clock biological_process owl:Class
GO:0034664 biolink:NamedThing Ig heavy chain-bound endoplasmic reticulum chaperone complex A protein complex that is located in the endoplasmic reticulum (ER) and is formed by the association of an immunoglobulin heavy chain with the proteins of the ER chaperone complex; the latter include BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. got7fsn_ti Ig heavy chain-bound ER chaperone complex|immunoglobulin heavy chain-bound endoplasmic reticulum chaperone complex cellular_component owl:Class
GO:0050207 biolink:NamedThing plasmanylethanolamine desaturase activity Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O. got7fsn_ti alkylacylglycerophosphoethanolamine desaturase activity|alkylacylglycero-phosphorylethanolamine dehydrogenase activity|plasmenylethanolamine desaturase activity|O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine,hydrogen-donor:oxygen oxidoreductase activity|dehydrogenase, alkyl-acylglycerophosphorylethanolamine|1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity|1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase activity RHEA:22956|EC:1.14.19.77|MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN molecular_function owl:Class
GO:0034190 biolink:NamedThing apolipoprotein receptor binding Binding to an apolipoprotein receptor. got7fsn_ti molecular_function owl:Class
GO:0018273 biolink:NamedThing protein-chromophore linkage via peptidyl-N6-retinal-L-lysine The modification of peptidyl-lysine to form N6-retinal-L-lysine. got7fsn_ti RESID:AA0120 biological_process owl:Class
GO:0071558 biolink:NamedThing histone H3-tri/di-methyl-lysine-27 demethylase activity Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone H3K27me2 demethylase activity|histone H3K27me3 demethylase activity|histone demethylase activity (H3-K27 specific) mah 2010-01-15T11:33:17Z RHEA:60224|EC:1.14.11.68|Reactome:R-HSA-3222593|Reactome:R-HSA-5617431|Reactome:R-HSA-5617887 molecular_function owl:Class
GO:0039671 biolink:NamedThing evasion by virus of host natural killer cell activity Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells. got7fsn_ti evasion by virus of host natural killer cell response|viral immunoevasion of host NK cell|evasion by virus of host NK cell killing|modulation of host NK-cell activity by virus|suppression by virus of host natural killer cell function|protection by virus against host NK cell cytotoxicity bf 2013-09-25T11:04:53Z biological_process owl:Class
GO:0019228 biolink:NamedThing neuronal action potential An action potential that occurs in a neuron. got7fsn_ti generation of action potential biological_process owl:Class
GO:0006648 biolink:NamedThing dihydrosphingosine-1-P pathway A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase. got7fsn_ti biological_process owl:Class
GO:0006646 biolink:NamedThing phosphatidylethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. got7fsn_ti phosphatidylethanolamine formation|phosphatidylethanolamine anabolism|phosphatidylethanolamine synthesis|phosphatidylethanolamine biosynthesis biological_process owl:Class
GO:0072318 biolink:NamedThing clathrin coat disassembly The disaggregation of a clathrin coat into its constituent components; results in stripping or removing the clathrin coat from clathrin-coated vesicles (CCV) before fusing with their targets. CVVs transport cargo from plasma membrane and trans-Golgi to the endosomal system. got7fsn_ti clathrin-coat disassembly|clathrin-coat uncoating|clathrin-coated vesicle uncoating mah 2010-10-26T12:03:37Z biological_process owl:Class
GO:0072319 biolink:NamedThing vesicle uncoating A protein depolymerization process that results in the disassembly of vesicle coat proteins. got7fsn_ti vesicle coat disassembly mah 2010-10-26T12:09:21Z biological_process owl:Class
GO:0047849 biolink:NamedThing dextransucrase activity Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = D-fructose + 1,6-alpha-D-glucosyl(n+1). got7fsn_ti sucrose 6-glucosyltransferase activity|sucrose-1,6-alpha-glucan glucosyltransferase activity|sucrose:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity|CEP|SGE EC:2.4.1.5|MetaCyc:DEXTRANSUCRASE-RXN molecular_function owl:Class
GO:0098791 biolink:NamedThing Golgi apparatus subcompartment A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus. got7fsn_ti Golgi subcompartment cellular_component owl:Class
GO:0002466 biolink:NamedThing peripheral tolerance induction to self antigen Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues. got7fsn_ti biological_process owl:Class
GO:0090114 biolink:NamedThing COPII-coated vesicle budding The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle. got7fsn_ti ER vesicle budding|COPII vesicle budding|ER exit tb 2009-12-06T09:21:16Z biological_process owl:Class
GO:0031948 biolink:NamedThing positive regulation of glucocorticoid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. got7fsn_ti up-regulation of glucocorticoid biosynthetic process|upregulation of glucocorticoid biosynthetic process|activation of glucocorticoid biosynthetic process|up regulation of glucocorticoid biosynthetic process|stimulation of glucocorticoid biosynthetic process biological_process owl:Class
GO:0050070 biolink:NamedThing lysolecithin acylmutase activity Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine. got7fsn_ti lysolecithin 2,3-acylmutase activity|lysolecithin migratase activity MetaCyc:LYSOLECITHIN-ACYLMUTASE-RXN|KEGG_REACTION:R03334|RHEA:24356|EC:5.4.1.1 molecular_function owl:Class
GO:0009254 biolink:NamedThing peptidoglycan turnover The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall. got7fsn_ti murein turnover GO:0009287 biological_process owl:Class
GO:0000270 biolink:NamedThing peptidoglycan metabolic process The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network. got7fsn_ti peptidoglycan metabolism|murein metabolic process|murein metabolism GO:0009284 biological_process owl:Class
GO:0035139 biolink:NamedThing pelvic fin morphogenesis The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. got7fsn_ti biological_process owl:Class
GO:0097509 biolink:NamedThing oxanine DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination. got7fsn_ti oxanine-DNA glycosylase activity pr 2013-09-26T16:03:58Z molecular_function owl:Class
GO:0034512 biolink:NamedThing box C/D RNA binding Binding to a box C/D small nucleolar RNA. got7fsn_ti box C/D snoRNA binding|box C/D sRNA binding https://github.com/geneontology/go-ontology/issues/20416 molecular_function owl:Class
GO:0048707 biolink:NamedThing instar larval or pupal morphogenesis The process, occurring during instar larval or pupal development, by which anatomical structures are generated and organized. got7fsn_ti biological_process owl:Class
GO:0016711 biolink:NamedThing flavonoid 3'-monooxygenase activity Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O. got7fsn_ti flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)|flavonoid 3'-hydroxylase activity|flavonoid 3-monooxygenase|NADPH:flavonoid-3'-hydroxylase activity|flavonoid 3-hydroxylase EC:1.14.14.82|RHEA:16337|MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0032286 biolink:NamedThing central nervous system myelin maintenance The process in which the structure and material content of mature central nervous system myelin is kept in a functional state. got7fsn_ti myelin maintenance in central nervous system biological_process owl:Class
GO:0043217 biolink:NamedThing myelin maintenance The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath. got7fsn_ti biological_process owl:Class
GO:0060600 biolink:NamedThing dichotomous subdivision of an epithelial terminal unit The process in which an epithelial cord, rod or tube bifurcates at its end. got7fsn_ti primary branching of an epithelium dph 2009-05-14T02:14:50Z biological_process owl:Class
GO:0018856 biolink:NamedThing benzoyl acetate-CoA ligase activity Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA. got7fsn_ti SABIO-RK:5058|KEGG_REACTION:R05452|UM-BBD_reactionID:r0242 molecular_function owl:Class
GO:0043722 biolink:NamedThing 4-hydroxyphenylacetate decarboxylase activity Catalysis of the reaction: (4-hydroxyphenyl)acetate + H(+) = 4-cresol + CO(2). got7fsn_ti 4-Hpd activity|4-hydroxyphenylacetate carboxy-lyase activity|p-hydroxyphenylacetate decarboxylase activity|p-Hpd activity|4-(hydroxyphenyl)acetate carboxy-lyase (4-methylphenol-forming) MetaCyc:4.1.1.83-RXN|EC:4.1.1.83|RHEA:22732|KEGG_REACTION:R07312 molecular_function owl:Class
GO:0048483 biolink:NamedThing autonomic nervous system development The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands. got7fsn_ti biological_process owl:Class
GO:0097242 biolink:NamedThing amyloid-beta clearance The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors. got7fsn_ti beta-amyloid clearance pr 2012-02-16T05:32:29Z biological_process owl:Class
GO:0038094 biolink:NamedThing Fc-gamma receptor signaling pathway A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region. got7fsn_ti Fc-gamma receptor signalling pathway bf 2012-02-16T05:22:46Z biological_process owl:Class
GO:0102280 biolink:NamedThing choline monooxygenase activity (NADP-dependent) Catalysis of the reaction: choline + NADP = betaine aldehyde + NADPH + H+. got7fsn_ti MetaCyc:RXN-12582 molecular_function owl:Class
GO:0002351 biolink:NamedThing serotonin production involved in inflammatory response The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti serotonin production involved in acute inflammatory response biological_process owl:Class
GO:0002532 biolink:NamedThing production of molecular mediator involved in inflammatory response The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti production of molecular mediator involved in acute inflammatory response|production of cellular mediator of acute inflammation biological_process owl:Class
GO:0030354 biolink:NamedThing melanin-concentrating hormone activity The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals. got7fsn_ti molecular_function owl:Class
GO:0001652 biolink:NamedThing granular component A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm. got7fsn_ti pars granulosa NIF_Subcellular:sao1217793903 cellular_component owl:Class
GO:0018353 biolink:NamedThing protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine. got7fsn_ti GO:0018380 RESID:AA0131 biological_process owl:Class
GO:0017009 biolink:NamedThing protein-phycocyanobilin linkage The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin. got7fsn_ti RESID:AA0131 biological_process owl:Class
GO:0031970 biolink:NamedThing organelle envelope lumen The region between the inner and outer lipid bilayers of an organelle envelope. got7fsn_ti organelle intermembrane space cellular_component owl:Class
GO:0031974 biolink:NamedThing membrane-enclosed lumen The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen. got7fsn_ti cellular_component owl:Class
GO:0000419 biolink:NamedThing RNA polymerase V complex RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits. got7fsn_ti DNA-directed RNA polymerase V complex|DNA-directed RNA polymerase IVb complex GO:0080137 cellular_component owl:Class
GO:0015433 biolink:NamedThing ABC-type peptide antigen transporter activity Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate. got7fsn_ti ATP-dependent peptide antigen transmembrane transporter activity|peptide antigen transporter activity|major histocompatibility peptide transporter activity|ATPase-coupled peptide antigen transmembrane transporter activity|peptide antigen-transporting ATPase activity|peptide antigen ABC transporter Reactome:R-HSA-983144|TC:3.A.1.209.1|Reactome:R-HSA-1236949 molecular_function owl:Class
GO:0015440 biolink:NamedThing ABC-type peptide transporter activity Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria. got7fsn_ti peptide ABC transporter|ATPase-coupled peptide transmembrane transporter activity|ATP-dependent peptide transmembrane transporter activity|peptide-transporting ATPase activity EC:7.4.2.5|RHEA:14429|MetaCyc:3.6.3.43-RXN molecular_function owl:Class
GO:1990067 biolink:NamedThing intrachromosomal DNA recombination The process of DNA recombination occurring within a single chromosome. got7fsn_ti intrastrand DNA recombination tb 2013-03-27T21:11:35Z biological_process owl:Class
GO:0044871 biolink:NamedThing negative regulation by host of viral glycoprotein metabolic process A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process. got7fsn_ti jl 2014-09-18T14:28:48Z biological_process owl:Class
GO:0044870 biolink:NamedThing modulation by host of viral glycoprotein metabolic process A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process. got7fsn_ti jl 2014-09-18T14:26:19Z biological_process owl:Class
GO:0044518 biolink:NamedThing positive regulation of vasoactive intestinal polypeptide receptor activity in other organism A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism. got7fsn_ti positive regulation of VIP receptor activity in other organism jl 2012-02-26T11:50:34Z biological_process owl:Class
GO:0044517 biolink:NamedThing modulation of vasoactive intestinal polypeptide receptor activity in other organism The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism. got7fsn_ti regulation of vasoactive intestinal polypeptide receptor activity in other organism|modulation of VIP receptor activity in other organism jl 2012-02-26T11:48:32Z biological_process owl:Class
GO:0045323 biolink:NamedThing interleukin-1 receptor complex A protein complex that binds interleukin-1; comprises an alpha and a beta subunit. got7fsn_ti IL-1 receptor complex cellular_component owl:Class
GO:0046849 biolink:NamedThing bone remodeling The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. got7fsn_ti bone remodelling Wikipedia:Bone_remodeling biological_process owl:Class
GO:0062105 biolink:NamedThing RNA 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide. got7fsn_ti dph 2019-01-23T14:23:00Z RHEA:58956 molecular_function owl:Class
GO:0043771 biolink:NamedThing cytidine kinase activity Catalysis of the reaction: ATP + cytidine = ADP + CMP. got7fsn_ti molecular_function owl:Class
GO:0021586 biolink:NamedThing pons maturation A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. got7fsn_ti biological_process owl:Class
GO:0001642 biolink:NamedThing group III metabotropic glutamate receptor activity A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. got7fsn_ti molecular_function owl:Class
GO:0038007 biolink:NamedThing netrin-activated signaling pathway A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. got7fsn_ti netrin-mediated signaling pathway|netrin signaling pathway|netrin-activated signal transduction pathway|netrin-activated signalling pathway bf 2011-06-10T02:24:59Z biological_process owl:Class
GO:0008911 biolink:NamedThing lactaldehyde dehydrogenase activity Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+. got7fsn_ti nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity|(S)-lactaldehyde:NAD+ oxidoreductase activity|L-lactaldehyde:NAD oxidoreductase activity RHEA:14277|MetaCyc:LACTALDDEHYDROG-RXN|EC:1.2.1.22 molecular_function owl:Class
GO:0000215 biolink:NamedThing tRNA 2'-phosphotransferase activity Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate. got7fsn_ti Tpt1|2'-phosphotransferase activity|yeast 2'-phosphotransferase activity|Tpt1p|2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity|2'-phospho-tRNA:NAD+ phosphotransferase activity GO:0008665 MetaCyc:2.7.1.160-RXN|EC:2.7.1.160|RHEA:23324 molecular_function owl:Class
GO:0060576 biolink:NamedThing intestinal epithelial cell development The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure. got7fsn_ti dph 2009-05-06T08:20:24Z biological_process owl:Class
GO:0002066 biolink:NamedThing columnar/cuboidal epithelial cell development The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. got7fsn_ti biological_process owl:Class
GO:0008885 biolink:NamedThing glutathionylspermidine synthase activity Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate. got7fsn_ti gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]|glutathione:spermidine ligase (ADP-forming) activity|GSP synthetase activity|glutathionylspermidine synthetase activity|gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity EC:6.3.1.8|RHEA:21272|MetaCyc:GSPSYN-RXN molecular_function owl:Class
GO:0061586 biolink:NamedThing positive regulation of transcription by transcription factor localization Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor. got7fsn_ti dph 2014-01-31T08:43:43Z biological_process owl:Class
GO:0102303 biolink:NamedThing resveratrol 3,5-O-dimethyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + trans-resveratrol <=> 2 S-adenosyl-L-homocysteine + pterostilbene + 2 H+. got7fsn_ti MetaCyc:RXN-12805|RHEA:32103|EC:2.1.1.240 molecular_function owl:Class
GO:0021712 biolink:NamedThing candelabrum cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0071382 biolink:NamedThing cellular response to prostaglandin I stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus. got7fsn_ti mah 2009-12-11T03:45:10Z biological_process owl:Class
GO:0071379 biolink:NamedThing cellular response to prostaglandin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. got7fsn_ti mah 2009-12-11T03:33:52Z biological_process owl:Class
GO:0022034 biolink:NamedThing rhombomere cell proliferation The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population. got7fsn_ti biological_process owl:Class
GO:0009583 biolink:NamedThing detection of light stimulus The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal. got7fsn_ti perception of light|detection of light biological_process owl:Class
GO:0052667 biolink:NamedThing phosphomethylethanolamine N-methyltransferase activity Catalysis of the reaction: N-methylethanolamine phosphate + S-adenosyl-L-methionine = N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+). got7fsn_ti N-methylethanolamine phosphate N-methyltransferase activity|S-adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase activity ai 2011-04-11T11:36:47Z KEGG_REACTION:R06868|RHEA:25321|MetaCyc:RXN-5642|EC:2.1.1.103 molecular_function owl:Class
GO:0150020 biolink:NamedThing basal dendrite arborization The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches. got7fsn_ti bc 2017-12-22T11:32:31Z biological_process owl:Class
GO:0150019 biolink:NamedThing basal dendrite morphogenesis The process in which the anatomical structures of a basal dendrite are generated and organized. got7fsn_ti bc 2017-12-22T11:26:07Z biological_process owl:Class
GO:0030496 biolink:NamedThing midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. got7fsn_ti Wikipedia:Midbody_(cell_biology) cellular_component owl:Class
GO:0003959 biolink:NamedThing NADPH dehydrogenase activity Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor. got7fsn_ti NADPH2 diaphorase activity|TPNH dehydrogenase activity|triphosphopyridine nucleotide diaphorase activity|OYE|NADPH-dehydrogenase activity|triphosphopyridine diaphorase activity|dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity|reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity|NADPH2-dehydrogenase activity|old yellow enzyme|NADPH:(acceptor) oxidoreductase activity|NADPH diaphorase activity|NADPH:acceptor oxidoreductase activity|TPNH-diaphorase activity GO:0016660|GO:0008468 RHEA:13149|EC:1.6.99.1|Reactome:R-HSA-9027631|Reactome:R-HSA-9018867|MetaCyc:NADPH-DEHYDROGENASE-RXN|Reactome:R-HSA-9027625|Reactome:R-HSA-9018901|UM-BBD_enzymeID:e0523|Reactome:R-HSA-9027632 molecular_function owl:Class
GO:0007364 biolink:NamedThing establishment of terminal gap gene boundary Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes. got7fsn_ti biological_process owl:Class
GO:0072278 biolink:NamedThing metanephric comma-shaped body morphogenesis The process in which the metanephric comma-shaped body is generated and organized. The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros. got7fsn_ti mah 2010-04-01T03:14:42Z biological_process owl:Class
GO:0072049 biolink:NamedThing comma-shaped body morphogenesis The process in which the comma-shaped body is generated and organized. The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron. got7fsn_ti mah 2010-01-25T03:44:48Z biological_process owl:Class
GO:0021709 biolink:NamedThing cerebellar basket cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0140568 biolink:NamedThing extraction of mislocalized protein from membrane The removal of a mislocalized protein from a cellular membrane. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20237 pg 2020-12-15T07:35:10Z biological_process owl:Class
GO:0032333 biolink:NamedThing activin secretion The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone. got7fsn_ti biological_process owl:Class
GO:0102807 biolink:NamedThing cyanidin 3-O-glucoside 2''-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-O-sophoroside + UDP + H+. got7fsn_ti MetaCyc:RXN-8176 molecular_function owl:Class
GO:0003035 biolink:NamedThing detection of increased carbon dioxide by carotid body chemoreceptor signaling The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body. got7fsn_ti detection of increased carbon dioxide by carotid body chemoreceptor signalling biological_process owl:Class
GO:0015251 biolink:NamedThing ammonium channel activity Enables the facilitated diffusion of ammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti molecular_function owl:Class
GO:0005261 biolink:NamedThing cation channel activity Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient. got7fsn_ti non-selective cation channel activity|cation diffusion facilitator activity GO:0015281|GO:0015338 Reactome:R-HSA-1296043|Reactome:R-HSA-1168376|Reactome:R-HSA-2089943|Reactome:R-HSA-169683|Reactome:R-HSA-426223|Reactome:R-HSA-4420052 molecular_function owl:Class
GO:1900588 biolink:NamedThing violaceol I metabolic process The chemical reactions and pathways involving violaceol I. got7fsn_ti violaceol I metabolism di 2012-05-15T06:50:48Z biological_process owl:Class
GO:1990533 biolink:NamedThing Dom34-Hbs1 complex A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay. got7fsn_ti Dom34:Hbs1 complex mcc 2014-11-07T20:49:03Z cellular_component owl:Class
GO:0007130 biolink:NamedThing synaptonemal complex assembly The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination. got7fsn_ti synaptonemal complex formation biological_process owl:Class
GO:0140675 biolink:NamedThing ATP-dependent histone unloader activity Removing a histone or a histone complex from DNA. got7fsn_ti histone unloader activity|histone unloading activity https://github.com/geneontology/go-ontology/issues/21733 pg 2021-06-29T12:43:10Z molecular_function owl:Class
GO:0010676 biolink:NamedThing positive regulation of cellular carbohydrate metabolic process Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. got7fsn_ti biological_process owl:Class
GO:0045913 biolink:NamedThing positive regulation of carbohydrate metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate. got7fsn_ti activation of carbohydrate metabolic process|positive regulation of carbohydrate metabolism|up regulation of carbohydrate metabolic process|upregulation of carbohydrate metabolic process|stimulation of carbohydrate metabolic process|up-regulation of carbohydrate metabolic process biological_process owl:Class
GO:0071173 biolink:NamedThing spindle assembly checkpoint signaling A signaling process that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle. got7fsn_ti signal transduction involved in spindle assembly checkpoint|spindle assembly checkpoint|SAC https://github.com/geneontology/go-ontology/issues/20935 Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic). mah 2009-11-23T12:36:57Z GO:0072486 biological_process owl:Class
GO:0031577 biolink:NamedThing spindle checkpoint signaling A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle. got7fsn_ti spindle checkpoint|signal transduction involved in spindle checkpoint https://github.com/geneontology/go-ontology/issues/20935 Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term. GO:0072416 Wikipedia:Spindle_checkpoint biological_process owl:Class
GO:0046792 biolink:NamedThing suppression by virus of host cell cycle arrest Viral interference in host cell processes that lead cell cycle arrest, allowing cell division to occur. got7fsn_ti viral inhibition of cell cycle arrest|negative regulation by virus of cell cycle arrest biological_process owl:Class
GO:0019055 biolink:NamedThing modification by virus of host cell cycle regulation Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication. got7fsn_ti viral perturbation of cell cycle regulation biological_process owl:Class
GO:0035922 biolink:NamedThing foramen ovale closure The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow. got7fsn_ti foramen ovale of heart closure bf 2011-07-05T01:39:54Z biological_process owl:Class
GO:0016409 biolink:NamedThing palmitoyltransferase activity Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. got7fsn_ti Reactome:R-HSA-203567|Reactome:R-HSA-5686304 molecular_function owl:Class
GO:0001674 biolink:NamedThing female germ cell nucleus The nucleus of the female germ cell, a reproductive cell in females. got7fsn_ti female germ-cell nucleus GO:0043080 cellular_component owl:Class
GO:0050864 biolink:NamedThing regulation of B cell activation Any process that modulates the frequency, rate or extent of B cell activation. got7fsn_ti regulation of B lymphocyte activation|regulation of B-lymphocyte activation|regulation of B-cell activation biological_process owl:Class
GO:0009275 biolink:NamedThing Gram-positive-bacterium-type cell wall A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria. got7fsn_ti cell wall of Gram-positive Bacteria|20-80nm peptidoglycan-based cell wall cellular_component owl:Class
GO:0009274 biolink:NamedThing peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. got7fsn_ti peptidoglycan|murein sacculus|envelope cellular_component owl:Class
GO:0044001 biolink:NamedThing migration in host The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti migration within host biological_process owl:Class
GO:0034582 biolink:NamedThing 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxy-4-methyloctanoyl-CoA = 4-methyl-3-oxooctanoyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0926 molecular_function owl:Class
GO:0072251 biolink:NamedThing metanephric juxtaglomerulus cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the metanephros as it progresses from its formation to the mature state. got7fsn_ti mah 2010-03-19T03:54:35Z biological_process owl:Class
GO:0060927 biolink:NamedThing cardiac pacemaker cell fate commitment The commitment of cells to pacemaker cell fates and their capacity to differentiate into pacemaker cells. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions. got7fsn_ti pacemaker cell fate commitment dph 2009-09-29T11:54:22Z biological_process owl:Class
GO:0060923 biolink:NamedThing cardiac muscle cell fate commitment The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. got7fsn_ti cardiomyocyte cell fate commitment|heart muscle cell fate commitment dph 2009-09-29T11:13:32Z biological_process owl:Class
GO:0072590 biolink:NamedThing N-acetyl-L-aspartate-L-glutamate ligase activity Catalysis of the reaction: ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetylaspartyl-glutamate. got7fsn_ti mah 2011-02-10T03:20:41Z Reactome:R-HSA-8942575 molecular_function owl:Class
GO:0052585 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound. got7fsn_ti 2010-08-13T10:29:06Z EC:1.4.5.- molecular_function owl:Class
GO:0046510 biolink:NamedThing UDP-sulfoquinovose:DAG sulfoquinovosyltransferase activity Catalysis of the reaction: UDP-sulfoquinovose + 1,2-diacylglycerol = sulfoquinovosyldiacylglycerol + UDP. got7fsn_ti sulfolipid synthase|UDP-sulphoquinovose:DAG sulphoquinovosyltransferase activity MetaCyc:RXN-1224|RHEA:49468 molecular_function owl:Class
GO:1990859 biolink:NamedThing cellular response to endothelin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). got7fsn_ti sl 2015-09-24T15:39:48Z biological_process owl:Class
GO:0071375 biolink:NamedThing cellular response to peptide hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. got7fsn_ti cellular response to polypeptide hormone stimulus mah 2009-12-11T03:24:18Z biological_process owl:Class
GO:0046205 biolink:NamedThing nor-spermidine catabolic process The chemical reactions and pathways resulting in the breakdown of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. got7fsn_ti nor-spermidine breakdown|nor-spermidine catabolism|nor-spermidine degradation biological_process owl:Class
GO:0006598 biolink:NamedThing polyamine catabolic process The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. got7fsn_ti polyamine catabolism|polyamine breakdown|polyamine degradation biological_process owl:Class
GO:0001730 biolink:NamedThing 2'-5'-oligoadenylate synthetase activity Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA. got7fsn_ti (2-5')oligo(A) synthetase activity|2'-5' oligoadenylate synthetase activity|oligo-2',5'-adenylate synthetase activity|2-5A synthetase activity EC:2.7.7.84|Reactome:R-HSA-8985091|Reactome:R-HSA-8985104|MetaCyc:RXN-10798|MetaCyc:RXN-13648|Reactome:R-HSA-8983680|RHEA:34407 molecular_function owl:Class
GO:0061798 biolink:NamedThing GTP 3',8'-cyclase activity Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate. got7fsn_ti dph 2016-10-06T14:26:11Z MetaCyc:RXN-8340|RHEA:49576|EC:4.1.99.22 molecular_function owl:Class
GO:0018991 biolink:NamedThing oviposition The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water. got7fsn_ti post-mating oviposition|egg-laying|egg laying GO:0060403 Wikipedia:Oviposition biological_process owl:Class
GO:0033791 biolink:NamedThing 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity Catalysis of the reaction: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O + acceptor = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + reduced acceptor. got7fsn_ti 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate 24-hydroxylase activity|trihydroxycoprostanoyl-CoA oxidase activity|(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA:acceptor 24-oxidoreductase (24R-hydroxylating) activity|THC-CoA oxidase activity|THCA-CoA oxidase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA oxidase activity MetaCyc:1.17.99.3-RXN|RHEA:15733|EC:1.17.99.3 molecular_function owl:Class
GO:0102342 biolink:NamedThing 3-oxo-cerotoyl-CoA reductase activity Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA + NADP <=> 3-oxohexacosanoyl-CoA + NADPH + H+. got7fsn_ti MetaCyc:RXN-13301|EC:1.1.1.330 molecular_function owl:Class
GO:0097626 biolink:NamedThing low-affinity L-arginine transmembrane transporter activity Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low affinity L-arginine transmembrane transporter activity pr 2014-08-20T14:24:22Z molecular_function owl:Class
GO:0097625 biolink:NamedThing low-affinity basic amino acid transmembrane transporter activity Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low affinity basic amino acid transmembrane transporter activity pr 2014-08-20T14:23:18Z molecular_function owl:Class
GO:0045455 biolink:NamedThing ecdysteroid metabolic process The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females. got7fsn_ti ecdysteroid metabolism biological_process owl:Class
GO:0102238 biolink:NamedThing geraniol kinase activity (ATP-dependent) activity Catalysis of the reaction: geraniol + ATP = geranyl monophosphate + ADP + H+. got7fsn_ti MetaCyc:RXN-12307 molecular_function owl:Class
GO:0052670 biolink:NamedThing geraniol kinase activity Catalysis of the reaction: geraniol + nucleoside triphosphate = geranyl monophosphate + nucleoside diphosphate. got7fsn_ti geraniol phosphotransferase activity ai 2011-04-11T03:14:02Z molecular_function owl:Class
GO:0018481 biolink:NamedThing 4-hydroxymuconic-semialdehyde dehydrogenase activity Catalysis of the reaction: cis,trans-4-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 2 H(+) + maleylacetate + NADH. got7fsn_ti 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity EC:1.2.1.61|RHEA:22420|MetaCyc:1.2.1.61-RXN|UM-BBD_reactionID:r0229|KEGG_REACTION:R05236 molecular_function owl:Class
GO:0010905 biolink:NamedThing negative regulation of UDP-glucose catabolic process Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. got7fsn_ti negative regulation of UDP-glucose catabolism biological_process owl:Class
GO:0010677 biolink:NamedThing negative regulation of cellular carbohydrate metabolic process Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. got7fsn_ti biological_process owl:Class
GO:0018722 biolink:NamedThing 1-phenanthrol sulfotransferase activity Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate. got7fsn_ti 1-phenanthrol sulphotransferase activity UM-BBD_reactionID:r0565 molecular_function owl:Class
GO:0019111 biolink:NamedThing phenanthrol sulfotransferase activity Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate. got7fsn_ti phenanthrol sulphotransferase activity molecular_function owl:Class
GO:0031125 biolink:NamedThing rRNA 3'-end processing Any process involved in forming the mature 3' end of an rRNA molecule. got7fsn_ti rRNA 3' end processing biological_process owl:Class
GO:0019121 biolink:NamedThing peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan. got7fsn_ti RESID:AA0218 biological_process owl:Class
GO:0010458 biolink:NamedThing exit from mitosis The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. got7fsn_ti exit from mitotic division|mitotic exit biological_process owl:Class
GO:0044772 biolink:NamedThing mitotic cell cycle phase transition The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase. got7fsn_ti jl 2013-02-28T13:09:33Z biological_process owl:Class
GO:0042621 biolink:NamedThing poly(3-hydroxyalkanoate) biosynthetic process The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. got7fsn_ti PHA biosynthesis|poly(3-hydroxyalkanoate) biosynthesis|PHA biosynthetic process|poly(3-hydroxyalkanoate) formation|poly(3-hydroxyalkanoate) anabolism|poly(3-hydroxyalkanoate) synthesis biological_process owl:Class
GO:0050036 biolink:NamedThing L-threonate 3-dehydrogenase activity Catalysis of the reaction: L-threonate + NAD(+) = 3-dehydro-L-threonate + H(+) + NADH. got7fsn_ti threonate dehydrogenase activity|L-threonic acid dehydrogenase activity|L-threonate:NAD+ 3-oxidoreductase activity EC:1.1.1.129|KEGG_REACTION:R03733|MetaCyc:L-THREONATE-3-DEHYDROGENASE-RXN|RHEA:23376 molecular_function owl:Class
GO:0004400 biolink:NamedThing histidinol-phosphate transaminase activity Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. got7fsn_ti imidazolylacetolphosphate transaminase activity|imidazolylacetolphosphate aminotransferase activity|histidinol-phosphate aminotransferase activity|IAP transaminase activity|glutamic-imidazoleacetol phosphate transaminase activity|imidazoleacetol phosphate transaminase activity|imidazole acetol-phosphate transaminase activity|histidinol phosphate aminotransferase activity|L-histidinol phosphate aminotransferase activity|L-histidinol-phosphate:2-oxoglutarate aminotransferase activity|histidine:imidazoleacetol phosphate transaminase activity EC:2.6.1.9|MetaCyc:HISTAMINOTRANS-RXN|RHEA:23744 molecular_function owl:Class
GO:0034467 biolink:NamedThing esterosome lumen The volume enclosed by the membrane of an esterosome. got7fsn_ti cellular_component owl:Class
GO:0052871 biolink:NamedThing alpha-tocopherol omega-hydroxylase activity Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O . got7fsn_ti alpha-tocopherol 13-hydroxylase activity ai 2012-01-30T03:06:27Z MetaCyc:RXN-11003 molecular_function owl:Class
GO:0052870 biolink:NamedThing tocopherol omega-hydroxylase activity Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13'-hydroxy-tocopherol + NADP+ + H2O . got7fsn_ti tocopherol 13-hydroxylase activity ai 2012-01-30T03:06:27Z molecular_function owl:Class
GO:0004766 biolink:NamedThing spermidine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. got7fsn_ti putrescine aminopropyltransferase activity|aminopropyltransferase activity|spermidine synthetase activity|SpeE|S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity EC:2.5.1.16|RHEA:12721|MetaCyc:SPERMIDINESYN-RXN|Reactome:R-HSA-351215 molecular_function owl:Class
GO:0106305 biolink:NamedThing mannogen catabolic process The chemical reactions and pathways resulting in the breakdown of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. got7fsn_ti beta-1,2-mannan catabolism|mannogen breakdown|mannogen degradation|beta-1,2-mannan catabolic process|mannogen catabolism hjd 2020-09-09T13:55:16Z biological_process owl:Class
GO:0097164 biolink:NamedThing ammonium ion metabolic process The chemical reactions and pathways involving the ammonium ion. got7fsn_ti ammonium ion metabolism|ammonium metabolic process pr 2011-09-28T04:21:30Z biological_process owl:Class
GO:0033338 biolink:NamedThing medial fin development The process whose specific outcome is the progression of a medial fin over time, from its formation to the mature structure. got7fsn_ti median fin development biological_process owl:Class
GO:0033333 biolink:NamedThing fin development The process whose specific outcome is the progression of a fin over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0047679 biolink:NamedThing arginine racemase activity Catalysis of the reaction: L-arginine = D-arginine. got7fsn_ti MetaCyc:ARGININE-RACEMASE-RXN|EC:5.1.1.9|RHEA:18069 molecular_function owl:Class
GO:0050059 biolink:NamedThing lombricine kinase activity Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine. got7fsn_ti ATP:lombricine N-phosphotransferase activity RHEA:23292|EC:2.7.3.5|MetaCyc:LOMBRICINE-KINASE-RXN molecular_function owl:Class
GO:0048765 biolink:NamedThing root hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a root hair cell. got7fsn_ti biological_process owl:Class
GO:0048764 biolink:NamedThing trichoblast maturation A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state. got7fsn_ti biological_process owl:Class
GO:0052638 biolink:NamedThing indole-3-butyrate beta-glucosyltransferase activity Catalysis of the reaction: indole-3-butyrate + UDP-D-glucose = indole-3-butyryl-beta-1-D-glucose + UDP. got7fsn_ti UDP-glucose:(indol-3-yl)butyrate beta-D-glucosyltransferase activity|uridine diphosphoglucose-indolebutyrate glucosyltransferase activity|UDPglucose:indole-3-butyrate beta-D-glucosyltransferase activity|IBA-Glc synthetase activity|indole-3-butyric acid glucosyltransferase activity|indol-3-ylbutyrylglucose synthase activity|UDPG-indol-3-ylbutyryl glucosyl transferase activity|IBA-glucose synthase activity|UDP-glucose:indol-3-ylbutyrate glucosyl-transferase activity|UDP-glucose:indol-3-ylbutyrate glucosyltransferase activity|IBAGlu synthase activity RHEA:62708|MetaCyc:RXN-11655 molecular_function owl:Class
GO:0052579 biolink:NamedThing (+)-pulegone reductase, (+)-isomenthone as substrate, activity Catalysis of the reaction: (+)-isomenthone + NADP+ = (+)-pulegone + NADPH + H+. got7fsn_ti (+)-isomenthone:NADP+ oxidoreductase activity ai 2010-08-09T04:28:00Z EC:1.3.1.81|MetaCyc:RXN-5164 molecular_function owl:Class
GO:0070643 biolink:NamedThing vitamin D 25-hydroxylase activity Catalysis of the hydroxylation of C-25 of any form of vitamin D. got7fsn_ti vitamin D2 25-hydroxylase activity|calciferol 25-hydroxylase activity|ergocalciferol 25-hydroxylase activity|cholecalciferol 25-hydroxylase activity mah 2009-05-08T03:42:29Z molecular_function owl:Class
GO:0097705 biolink:NamedThing vascular endothelial cell response to pulsatile fluid shear stress Any response to pulsatile fluid shear stress that occurs in a vascular endothelial cell. got7fsn_ti blood vessel endothelial cell response to pulsatile fluid shear stress pr 2016-01-27T14:22:44Z biological_process owl:Class
GO:0097699 biolink:NamedThing vascular endothelial cell response to fluid shear stress Any response to fluid shear stress in a vascular endothelial cell. got7fsn_ti blood vessel endothelial cell response to fluid shear stress pr 2016-01-27T12:37:32Z biological_process owl:Class
GO:0032020 biolink:NamedThing ISG15-protein conjugation The covalent addition to a protein of ISG15, a ubiquitin-like protein. got7fsn_ti biological_process owl:Class
GO:0042641 biolink:NamedThing actomyosin Any complex of actin, myosin, and accessory proteins. got7fsn_ti actomyosin structure|actomyosin complex cellular_component owl:Class
GO:0045135 biolink:NamedThing poly(beta-D-mannuronate) lyase activity Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. got7fsn_ti alginate lyase I activity|alginate lyase activity|poly(beta-D-1,4-mannuronide) lyase activity|alginase I|alginase activity|poly(mana) alginate lyase activity EC:4.2.2.3|MetaCyc:4.2.2.3-RXN molecular_function owl:Class
GO:0086014 biolink:NamedThing atrial cardiac muscle cell action potential An action potential that occurs in an atrial cardiac muscle cell. got7fsn_ti tb 2011-11-10T08:49:13Z biological_process owl:Class
GO:0086002 biolink:NamedThing cardiac muscle cell action potential involved in contraction An action potential that occurs in a cardiac muscle cell and is involved in its contraction. got7fsn_ti tb 2011-11-10T07:45:11Z biological_process owl:Class
GO:0072237 biolink:NamedThing metanephric proximal tubule development The process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. got7fsn_ti mah 2010-03-18T03:46:54Z biological_process owl:Class
GO:0072234 biolink:NamedThing metanephric nephron tubule development The progression of a metanephric nephron tubule over time, from its initial formation to the mature structure. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros. got7fsn_ti mah 2010-03-18T03:41:23Z biological_process owl:Class
GO:0045686 biolink:NamedThing negative regulation of glial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation. got7fsn_ti negative regulation of neuroglia differentiation|down-regulation of glial cell differentiation|inhibition of glial cell differentiation|negative regulation of glia cell differentiation|down regulation of glial cell differentiation|downregulation of glial cell differentiation biological_process owl:Class
GO:0010114 biolink:NamedThing response to red light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti response to red light stimulus biological_process owl:Class
GO:0070210 biolink:NamedThing Rpd3L-Expanded complex A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins. got7fsn_ti Clr6-LE complex cellular_component owl:Class
GO:0044083 biolink:NamedThing modulation by symbiont of host Rho protein signal transduction Any process in which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism. got7fsn_ti modulation of host Rho protein signalling by symbiont|regulation by symbiont of host Rho protein signal transduction|modulation by symbiont of host Rho protein mediated signal transduction|modulation by symbiont of host Rho protein-mediated signal transduction|modulation of host Rho protein signal transduction by symbiont|modulation of host Rho protein signaling by symbiont biological_process owl:Class
GO:0044082 biolink:NamedThing modulation by symbiont of host small GTPase mediated signal transduction Any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism. got7fsn_ti regulation by symbiont of host small GTPase mediated signal transduction|modulation of host small GTPase mediated signal transduction by symbiont biological_process owl:Class
GO:0110129 biolink:NamedThing SHREC2 complex A histone deacetylase complex formed by the association of an HP1 protein with a SHREC complex. The SHREC2 complex is required for deacetylation of H3K14, and mediates transcriptional gene silencing by limiting RNA polymerase II access to heterochromatin. In fission yeast, the complex contains the SHREC subunits Clr1, Clr2, Clr3, and Mit1, and the HP1 protein Chp2. got7fsn_ti kmv 2018-09-25T21:25:41Z cellular_component owl:Class
GO:0006704 biolink:NamedThing glucocorticoid biosynthetic process The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. got7fsn_ti glucocorticoid anabolism|glucocorticoid formation|glucocorticoid synthesis|glucocorticoid biosynthesis biological_process owl:Class
GO:0006694 biolink:NamedThing steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. got7fsn_ti steroid biosynthesis|steroidogenesis|steroid synthesis|steroid anabolism|steroid formation Wikipedia:Steroid_metabolisms#Steroid_biosynthesis biological_process owl:Class
GO:0018398 biolink:NamedThing peptidyl-phenylalanine bromination to L-3'-bromophenylalanine The bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine. got7fsn_ti RESID:AA0175 biological_process owl:Class
GO:0060394 biolink:NamedThing negative regulation of pathway-restricted SMAD protein phosphorylation Any process that decreases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. got7fsn_ti biological_process owl:Class
GO:0090101 biolink:NamedThing negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. got7fsn_ti negative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway tb 2009-11-13T10:56:52Z biological_process owl:Class
GO:0015189 biolink:NamedThing L-lysine transmembrane transporter activity Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. got7fsn_ti lysine permease activity|histidine/arginine/lysine/ornithine porter activity|L-lysine permease GO:0005293 molecular_function owl:Class
GO:0044627 biolink:NamedThing modulation of complement activation, classical pathway in other organism A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism. got7fsn_ti regulation of complement activation, classical pathway in other organism jl 2012-07-05T12:55:53Z biological_process owl:Class
GO:0052617 biolink:NamedThing ent-kaur-16-en-19-al oxidase activity Catalysis of the reaction: NADPH + ent-kaur-16-en-19-al + oxygen = H2O + NADP+ + ent-kaurenoate. got7fsn_ti EC:1.14.14.86|RHEA:10928|MetaCyc:RXN-7580 molecular_function owl:Class
GO:0007480 biolink:NamedThing imaginal disc-derived leg morphogenesis The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0070513 biolink:NamedThing death domain binding Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB. got7fsn_ti For binding to the death effector domain, consider instead the term 'death effector domain binding ; GO:0035877'. molecular_function owl:Class
GO:0034336 biolink:NamedThing misfolded RNA binding Binding to an RNA molecule that has assumed an incorrect conformation. got7fsn_ti RNA chaperone molecular_function owl:Class
GO:0030120 biolink:NamedThing vesicle coat A membrane coat found on a coated vesicle. got7fsn_ti NIF_Subcellular:sao1177708494 cellular_component owl:Class
GO:0051435 biolink:NamedThing BH4 domain binding Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein. got7fsn_ti molecular_function owl:Class
GO:0051400 biolink:NamedThing BH domain binding Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. got7fsn_ti Bcl-2 homology domain binding molecular_function owl:Class
GO:0071573 biolink:NamedThing shelterin complex assembly The aggregation, arrangement and bonding together of a set of components to form a shelterin complex. A shelterin complex is a nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. got7fsn_ti Pot1-Tpz1 complex assembly|Pot1 complex assembly|telosome assembly|shelterin complex formation mah 2010-01-26T01:45:20Z biological_process owl:Class
GO:0045514 biolink:NamedThing interleukin-16 receptor binding Binding to an interleukin-16 receptor. got7fsn_ti IL-16|interleukin-16 receptor ligand molecular_function owl:Class
GO:0048472 biolink:NamedThing threonine-phosphate decarboxylase activity Catalysis of the reaction: O-phospho-L-threonine + H(+) = (R)-1-aminopropan-2-yl phosphate + CO(2). got7fsn_ti L-threonine O-3-phosphate carboxy-lyase [(R)-1-aminopropan-2-yl-phosphate-forming]|CobD|L-threonine O-3-phosphate carboxy-lyase activity|L-threonine-O-3-phosphate decarboxylase activity RHEA:11492|MetaCyc:4.1.1.81-RXN|EC:4.1.1.81|KEGG_REACTION:R06530 molecular_function owl:Class
GO:0045006 biolink:NamedThing DNA deamination The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil. got7fsn_ti biological_process owl:Class
GO:0060792 biolink:NamedThing sweat gland development The progression of the sweat gland over time, from its formation to the mature structure. Sweat glands secrete an aqueous solution that is used in thermoregulation. got7fsn_ti dph 2009-08-04T12:35:12Z biological_process owl:Class
GO:0120212 biolink:NamedThing sperm head-tail coupling apparatus A centrosome-based structure consisting of two cylindrical microtubule-based centrioles and associated components which anchors the flagellum to the sperm head. got7fsn_ti HTCA|head-tail coupling apparatus krc 2019-06-07T23:08:46Z cellular_component owl:Class
GO:0060080 biolink:NamedThing inhibitory postsynaptic potential A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. got7fsn_ti IPSP|regulation of inhibitory post-synaptic membrane potential biological_process owl:Class
GO:0009906 biolink:NamedThing response to photoperiod, blue light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. got7fsn_ti biological_process owl:Class
GO:0016290 biolink:NamedThing palmitoyl-CoA hydrolase activity Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. got7fsn_ti fatty acyl thioesterase I|long-chain fatty-acyl-CoA hydrolase activity|palmityl thioesterase activity|palmityl thioesterase I|palmityl-CoA deacylase activity|palmitoyl-CoA deacylase activity|palmitoyl coenzyme A hydrolase activity|palmitoyl thioesterase activity GO:0016293 MetaCyc:PWY-5148|EC:3.1.2.2|MetaCyc:PALMITOYL-COA-HYDROLASE-RXN|RHEA:16645 molecular_function owl:Class
GO:0047617 biolink:NamedThing acyl-CoA hydrolase activity Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. got7fsn_ti acyl-CoA thioesterase I activity|acyl-CoA thioesterase activity|acyl-CoA thioesterase II activity|thioesterase II|acyl-CoA thiolesterase activity|acyl coenzyme A thioesterase activity|acyl coenzyme A hydrolase activity|thioesterase B GO:0016292|GO:0008778|GO:0016291 EC:3.1.2.20|Reactome:R-HSA-5690043|Reactome:R-HSA-5690066|RHEA:16781|MetaCyc:ACYL-COA-HYDROLASE-RXN|Reactome:R-HSA-5690042 molecular_function owl:Class
GO:0019785 biolink:NamedThing ISG15-specific protease activity Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates. got7fsn_ti Reactome:R-HSA-1678841|Reactome:R-HSA-5653786 molecular_function owl:Class
GO:0080068 biolink:NamedThing 5-methylthiopentyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 5-methylthiopentyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 5-methylthiopentyl-glucosinolate + adenosine 3',5'-bisphosphate. got7fsn_ti dhl 2009-04-13T04:06:59Z MetaCyc:RXNQT-4330 molecular_function owl:Class
GO:0047364 biolink:NamedThing desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + desulfoglucotropeolin = adenosine 3',5'-diphosphate + glucotropeolin + H(+). got7fsn_ti PAPS-desulfoglucosinolate sulfotransferase activity|desulphoglucosinolate sulphotransferase activity|3'-phosphoadenosine-5'-phosphosulfate:desulfoglucosinolate sulfotransferase activity|3'-phosphoadenylyl-sulfate:desulfoglucosinolate sulfotransferase activity EC:2.8.2.24|MetaCyc:2.8.2.24-RXN|KEGG_REACTION:R03214|RHEA:20281 molecular_function owl:Class
GO:0102167 biolink:NamedThing [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-serine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-serine. got7fsn_ti MetaCyc:RXN-11892|RHEA:48876|EC:3.2.1.169 molecular_function owl:Class
GO:0035916 biolink:NamedThing modulation of calcium channel activity in other organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism. got7fsn_ti bf 2011-07-01T11:51:38Z biological_process owl:Class
GO:0017025 biolink:NamedThing TBP-class protein binding Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). got7fsn_ti TBP binding|TBP-related factor (TRF) protein binding|TATA-binding protein binding molecular_function owl:Class
GO:0106210 biolink:NamedThing culmorin biosynthetic process The chemical reactions and pathways resulting in the formation of culmorin, a sesquiterpenoid fungal metabolite and mycotoxin produced by some ascomycete species such as Fusarium culmorum, F. graminearum, F. venenatum and Leptosphaeria oraemaris. got7fsn_ti culmorin formation|culmorin synthesis|culmorin anabolism|culmorin biosynthesis hjd 2019-05-13T17:30:41Z biological_process owl:Class
GO:0044849 biolink:NamedThing estrous cycle A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. got7fsn_ti jl 2014-07-16T13:41:42Z Wikipedia:Estrous_cycle biological_process owl:Class
GO:0032070 biolink:NamedThing regulation of deoxyribonuclease activity Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. got7fsn_ti deoxyribonuclease regulator|DNase regulator biological_process owl:Class
GO:0070545 biolink:NamedThing PeBoW complex A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively. got7fsn_ti cellular_component owl:Class
GO:0072286 biolink:NamedThing metanephric connecting tubule development The process whose specific outcome is the progression of the metanephric connecting tubule over time, from its formation to the mature structure. The metanephric connecting tubule is a tubular segment of the metanephric nephron; it connects the distal convoluted tubule to the collecting duct in the metanephros. got7fsn_ti metanephric connecting duct development mah 2010-04-09T03:30:09Z biological_process owl:Class
GO:0048318 biolink:NamedThing axial mesoderm development The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. got7fsn_ti biological_process owl:Class
GO:0007498 biolink:NamedThing mesoderm development The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue. got7fsn_ti biological_process owl:Class
GO:0008696 biolink:NamedThing 4-amino-4-deoxychorismate lyase activity Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate. got7fsn_ti ADC lyase activity|para-aminobenzoic acid (PABA) synthase|para-aminobenzoic acid synthase|enzyme X activity|4-amino-4-deoxychorismate pyruvate-lyase activity|4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)|p-aminobenzoate synthetase|aminodeoxychorismate lyase activity Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. RHEA:16201|MetaCyc:ADCLY-RXN|KEGG_REACTION:R05553|EC:4.1.3.38 molecular_function owl:Class
GO:0047112 biolink:NamedThing pyruvate oxidase activity Catalysis of the reaction: H(+) + O(2) + phosphate + pyruvate = acetyl phosphate + CO(2) + H(2)O(2). got7fsn_ti phosphate-dependent pyruvate oxidase activity|pyruvic oxidase activity|pyruvate:oxygen 2-oxidoreductase (phosphorylating) MetaCyc:1.2.3.3-RXN|KEGG_REACTION:R00207|RHEA:20848|EC:1.2.3.3 molecular_function owl:Class
GO:0016852 biolink:NamedThing sirohydrochlorin cobaltochelatase activity Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+. got7fsn_ti sirohydrochlorin cobalt-lyase activity|cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)|CbiX|anaerobic cobalt chelatase activity|CbiK|CbiXS MetaCyc:4.99.1.3-RXN|RHEA:15893|EC:4.99.1.3 molecular_function owl:Class
GO:0000403 biolink:NamedThing Y-form DNA binding Binding to a DNA segment shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end. got7fsn_ti splayed Y-form DNA binding|forked DNA binding molecular_function owl:Class
GO:0004026 biolink:NamedThing alcohol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester. got7fsn_ti alcohol acetyltransferase activity|acetyl-CoA:alcohol O-acetyltransferase activity|AATASE activity EC:2.3.1.84|MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN|RHEA:17229 molecular_function owl:Class
GO:0008871 biolink:NamedThing aminoglycoside 2''-nucleotidyltransferase activity Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside. got7fsn_ti NTP:gentamicin 2''-nucleotidyltransferase activity|gentamicin 2''-nucleotidyltransferase activity|gentamicin 2''- adenylyltransferase activity|gentamycin 2''-nucleotidyltransferase activity|2''-aminoglycoside nucleotidyltransferase activity EC:2.7.7.46|MetaCyc:2.7.7.46-RXN molecular_function owl:Class
GO:0034068 biolink:NamedThing aminoglycoside nucleotidyltransferase activity Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + nucleotidylaminoglycoside. got7fsn_ti streptomycin adenylate synthetase activity|streptomycin adenylylase activity|streptomycin adenylyltransferase activity|streptomycin adenyltransferase activity|aminoglycoside adenylyltransferase activity|streptomycin-spectinomycin adenylyltransferase activity molecular_function owl:Class
GO:0031699 biolink:NamedThing beta-3 adrenergic receptor binding Binding to a beta-3 adrenergic receptor. got7fsn_ti beta-3 adrenergic receptor ligand molecular_function owl:Class
GO:0018525 biolink:NamedThing 4-hydroxybenzoyl-CoA reductase activity Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin. got7fsn_ti 4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity|4-hydroxybenzoyl-coA reductase (dehydroxylating) activity KEGG_REACTION:R05316|UM-BBD_reactionID:r0158|MetaCyc:OHBENZCOARED-RXN|RHEA:29603|EC:1.1.7.1 molecular_function owl:Class
GO:0098581 biolink:NamedThing detection of external biotic stimulus The series of events in which an external biotic stimulus is detected and converted into a molecular signal. An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated. got7fsn_ti detection of exogenous biotic stimulus dos 2014-01-22T14:20:16Z biological_process owl:Class
GO:0102284 biolink:NamedThing L-threo-sphinganine reductase activity Catalysis of the reaction: L-threo-sphinganine + NADP <=> H+ + NADPH + 3-dehydrosphinganinium(1+). got7fsn_ti MetaCyc:RXN-12645 molecular_function owl:Class
GO:0010434 biolink:NamedThing bract formation The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. got7fsn_ti biological_process owl:Class
GO:0007208 biolink:NamedThing phospholipase C-activating serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). got7fsn_ti activation of phospholipase C activity by serotonin receptor signalling pathway|serotonin receptor, phospholipase C activating pathway|activation of phospholipase C activity by serotonin receptor signaling pathway biological_process owl:Class
GO:0000477 biolink:NamedThing generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. got7fsn_ti processing at C1 biological_process owl:Class
GO:0000967 biolink:NamedThing rRNA 5'-end processing Any process involved in forming the mature 5' end of an rRNA molecule. got7fsn_ti rRNA 5' end processing biological_process owl:Class
GO:0031024 biolink:NamedThing interphase microtubule organizing center assembly The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center. got7fsn_ti interphase microtubule organising center formation|interphase microtubule organizing centre assembly|interphase microtubule organizing center biogenesis|interphase microtubule organising center biosynthesis biological_process owl:Class
GO:0031023 biolink:NamedThing microtubule organizing center organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow. got7fsn_ti microtubule organising center organisation|microtubule organizing center organization and biogenesis biological_process owl:Class
GO:0019603 biolink:NamedThing toluene oxidation via 4-hydroxytoluene The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol). got7fsn_ti MetaCyc:TOLUENE-DEG-4-OH-PWY biological_process owl:Class
GO:0051081 biolink:NamedThing nuclear membrane disassembly The controlled breakdown of the nuclear membranes, for example during cellular division. got7fsn_ti nuclear envelope disassembly|nuclear envelope degradation|nuclear envelope catabolism|nuclear envelope breakdown biological_process owl:Class
GO:0030397 biolink:NamedThing membrane disassembly The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. got7fsn_ti membrane catabolism|membrane breakdown|membrane degradation biological_process owl:Class
GO:0097421 biolink:NamedThing liver regeneration The regrowth of lost or destroyed liver. got7fsn_ti pr 2012-11-07T10:22:43Z biological_process owl:Class
GO:0001889 biolink:NamedThing liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. got7fsn_ti biological_process owl:Class
GO:0031758 biolink:NamedThing Edg-5 sphingosine 1-phosphate receptor binding Binding to an Edg-5 sphingosine 1-phosphate receptor. got7fsn_ti Edg-5 sphingosine 1-phosphate receptor ligand molecular_function owl:Class
GO:0071740 biolink:NamedThing IgD B cell receptor complex An IgD immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti membrane-bound IgD|surface IgD Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0052489 biolink:NamedThing negative regulation by host of symbiont programmed cell death Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti down-regulation by host of symbiont programmed cell death|downregulation by host of symbiont programmed cell death|inhibition of symbiont programmed cell death|down regulation by host of symbiont programmed cell death|inhibition by host of symbiont programmed cell death biological_process owl:Class
GO:0051711 biolink:NamedThing negative regulation of killing of cells of other organism Any process that stops, prevents, or reduces the frequency, rate or extent of the killing by an organism of cells in another organism. got7fsn_ti down-regulation of killing of cells of another organism|negative regulation of killing of cells of another organism|down regulation of killing of cells of another organism|inhibition of killing of cells of another organism|negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction|downregulation of killing of cells of another organism https://github.com/geneontology/go-ontology/issues/20287 GO:0052490 biological_process owl:Class
GO:0097552 biolink:NamedThing mitochondrial double-strand break repair via homologous recombination The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences. got7fsn_ti mtDSB repair via homologous recombination Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable. pr 2014-01-22T10:09:10Z biological_process owl:Class
GO:0097551 biolink:NamedThing mitochondrial double-strand break repair The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. got7fsn_ti mtDSB repair Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable. pr 2014-01-22T10:06:54Z biological_process owl:Class
GO:0032047 biolink:NamedThing mitosome A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria. got7fsn_ti crypton In Giardia species, mitosomes are sometimes present between the two nuclei. Wikipedia:Mitosome cellular_component owl:Class
GO:0102140 biolink:NamedThing heparan sulfate N-deacetylase activity Catalysis of the reaction: H2O + [heparan sulfate]-N-acetyl-alpha-D-glucosamine = acetate + H+ + [heparan sulfate]-alpha-D-glucosamine. got7fsn_ti MetaCyc:RXN-11557 molecular_function owl:Class
GO:0001505 biolink:NamedThing regulation of neurotransmitter levels Any process that modulates levels of neurotransmitter. got7fsn_ti biological_process owl:Class
GO:0050446 biolink:NamedThing azobenzene reductase activity Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+. got7fsn_ti NADPH2:4-(dimethylamino)azobenzene oxidoreductase activity|NADPH-dependent azoreductase activity|NADPH:4-(dimethylamino)azobenzene oxidoreductase activity|dimethylaminobenzene reductase activity|azo-dye reductase activity|azoreductase activity|N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase activity|orange I azoreductase activity|azo reductase activity|p-dimethylaminoazobenzene azoreductase activity|new coccine (NC)-reductase|nicotinamide adenine dinucleotide (phosphate) azoreductase activity|NAD(P)H:1-(4'-sulfophenylazo)-2-naphthol oxidoreductase activity|NADPH2-dependent azoreductase activity|dibromopropylaminophenylazobenzoic azoreductase activity|NC-reductase activity|New coccine (NC)-reductase activity|methyl red azoreductase activity|N,N-dimethyl-4-phenylazoaniline azoreductase activity|orange II azoreductase activity|p-aminoazobenzene reductase activity RHEA:16269|UM-BBD_reactionID:r0808|MetaCyc:AZOBENZENE-REDUCTASE-RXN|EC:1.7.1.6 molecular_function owl:Class
GO:0071526 biolink:NamedThing semaphorin-plexin signaling pathway A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. got7fsn_ti semaphorin-plexin signalling pathway mah 2010-01-07T03:48:07Z biological_process owl:Class
GO:0072194 biolink:NamedThing kidney smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle in the kidney over time, from its formation to the mature structure. got7fsn_ti mah 2010-03-01T02:05:30Z biological_process owl:Class
GO:0048745 biolink:NamedThing smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0015079 biolink:NamedThing potassium ion transmembrane transporter activity Enables the transfer of potassium ions (K+) from one side of a membrane to the other. got7fsn_ti potassium transporter activity|potassium uptake transmembrane transporter activity|potassium uptake permease activity GO:0015388|GO:0022817 RHEA:29463 molecular_function owl:Class
GO:0035677 biolink:NamedThing posterior lateral line neuromast hair cell development The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti bf 2011-02-14T11:04:57Z biological_process owl:Class
GO:0035675 biolink:NamedThing neuromast hair cell development The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti bf 2011-02-14T11:01:42Z biological_process owl:Class
GO:0043446 biolink:NamedThing cellular alkane metabolic process The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells. got7fsn_ti alkane metabolism biological_process owl:Class
GO:0034428 biolink:NamedThing nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction. got7fsn_ti 5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process biological_process owl:Class
GO:0033793 biolink:NamedThing aureusidin synthase activity Catalysis of the reactions: 2',4,4',6'-tetrahydroxychalcone + O2 = aureusidin + H2O, and 2',3,4,4',6'-pentahydroxychalcone + 1/2 O2 = aureusidin + H2O. got7fsn_ti 2',4,4',6'-tetrahydroxychalcone:oxygen oxidoreductase activity molecular_function owl:Class
GO:0046993 biolink:NamedThing oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is oxygen. got7fsn_ti EC:1.21.3.- molecular_function owl:Class
GO:0000710 biolink:NamedThing meiotic mismatch repair A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis. got7fsn_ti biological_process owl:Class
GO:0052494 biolink:NamedThing occlusion by host of symbiont vascular system The process in which an organism reduces the flow of fluid within its symbiont's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0035002 biolink:NamedThing liquid clearance, open tracheal system The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system. got7fsn_ti tracheal liquid clearance biological_process owl:Class
GO:0042045 biolink:NamedThing epithelial fluid transport The directed movement of fluid across epithelia. got7fsn_ti biological_process owl:Class
GO:0002411 biolink:NamedThing T cell tolerance induction to tumor cell A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor. got7fsn_ti biological_process owl:Class
GO:0002424 biolink:NamedThing T cell mediated immune response to tumor cell An immune response mediated by a T cell triggered in response to the presence of a tumor cell. got7fsn_ti Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. biological_process owl:Class
GO:0035967 biolink:NamedThing cellular response to topologically incorrect protein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. got7fsn_ti cellular response to misfolded or unfolded protein bf 2011-08-03T11:44:50Z biological_process owl:Class
GO:0035852 biolink:NamedThing horizontal cell localization Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina. got7fsn_ti horizontal cell localisation|retinal horizontal cell positioning|laminar positioning of retinal horizontal cell|horizontal cell positioning bf 2011-05-11T01:56:40Z biological_process owl:Class
GO:0051674 biolink:NamedThing localization of cell Any process in which a cell is transported to, and/or maintained in, a specific location. got7fsn_ti establishment and maintenance of cell localization|localisation of cell|establishment and maintenance of localization of cell|cell localization biological_process owl:Class
GO:0038123 biolink:NamedThing toll-like receptor TLR1:TLR2 signaling pathway A series of molecular signals initiated by the binding of a heterodimeric TLR1:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti TLR2:TLR1 signaling pathway|toll-like receptor TLR1:TLR2 signalling pathway bf 2012-03-23T10:20:13Z biological_process owl:Class
GO:0030372 biolink:NamedThing high molecular weight B cell growth factor receptor binding Binding to a high molecular weight B cell growth factor receptor. got7fsn_ti high molecular weight B-cell growth factor receptor binding|high molecular weight B lymphocyte growth factor receptor binding|high molecular weight B-lymphocyte growth factor receptor binding|high molecular weight B cell growth factor receptor ligand molecular_function owl:Class
GO:0016429 biolink:NamedThing tRNA (adenine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. got7fsn_ti transfer ribonucleate adenine 1-methyltransferase activity|adenine-1-methylase activity|1-methyladenine transfer RNA methyltransferase activity|S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity|transfer RNA (adenine-1) methyltransferase activity|S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity Reactome:R-HSA-6787594|Reactome:R-HSA-6783492|Reactome:R-HSA-6787525 molecular_function owl:Class
GO:0016426 biolink:NamedThing tRNA (adenine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine. got7fsn_ti molecular_function owl:Class
GO:1990761 biolink:NamedThing growth cone lamellipodium A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments. got7fsn_ti sl 2015-06-05T22:31:19Z cellular_component owl:Class
GO:0030027 biolink:NamedThing lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. got7fsn_ti Wikipedia:Lamellipodia cellular_component owl:Class
GO:0031535 biolink:NamedThing plus-end directed microtubule sliding The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules. got7fsn_ti biological_process owl:Class
GO:0032034 biolink:NamedThing myosin II head/neck binding Binding to the head/neck region of a myosin II heavy chain. got7fsn_ti molecular_function owl:Class
GO:0032038 biolink:NamedThing myosin II heavy chain binding Binding to a heavy chain of a myosin II complex. got7fsn_ti molecular_function owl:Class
GO:1990619 biolink:NamedThing histone H3-K9 deacetylation The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone. got7fsn_ti al 2015-01-23T17:27:16Z biological_process owl:Class
GO:0007281 biolink:NamedThing germ cell development The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. got7fsn_ti germ-cell development|primordial germ cell development biological_process owl:Class
GO:0016737 biolink:NamedThing oxidoreductase activity, acting on reduced flavodoxin as donor Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti EC:1.19.-.- molecular_function owl:Class
GO:0052906 biolink:NamedThing tRNA (guanine(37)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine. got7fsn_ti transfer RNA (m(1)G(37)) methyltransferase activity|tRNA-(N(1)G37) methyltransferase activity|tRNA (m(1)G(37)) methyltransferase activity EC:2.1.1.228|RHEA:36899|MetaCyc:RXN-12458 molecular_function owl:Class
GO:0042082 biolink:NamedThing GSI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage. got7fsn_ti GPI/GSI anchor biosynthesis|GSI anchor anabolism|GPI/GSI anchor biosynthetic process|GSI anchor synthesis|GSI anchor formation|GSI anchor biosynthesis biological_process owl:Class
GO:0102643 biolink:NamedThing scalarane-17alpha-19-diol synthase activity Catalysis of the reaction: scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O. got7fsn_ti MetaCyc:RXN-15755 molecular_function owl:Class
GO:0061502 biolink:NamedThing early endosome to recycling endosome transport The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes. got7fsn_ti dph 2013-01-04T07:24:56Z biological_process owl:Class
GO:0043145 biolink:NamedThing sno(s)RNA 3'-end cleavage The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional. got7fsn_ti sRNA 3'-end cleavage|snoRNA 3'-end cleavage|sno(s)RNA 3' end cleavage https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0090502 biolink:NamedThing RNA phosphodiester bond hydrolysis, endonucleolytic The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. got7fsn_ti tb 2012-10-22T12:05:27Z biological_process owl:Class
GO:1990259 biolink:NamedThing histone-glutamine methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine. got7fsn_ti sp 2014-01-02T15:10:29Z molecular_function owl:Class
GO:0043767 biolink:NamedThing pyrrolysyl-tRNA synthetase activity Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl). got7fsn_ti PylRS|pyrrolysine-tRNA ligase activity RHEA:19277|EC:6.1.1.26|MetaCyc:6.1.1.26-RXN molecular_function owl:Class
GO:0005846 biolink:NamedThing nuclear cap binding complex A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export. got7fsn_ti snRNA cap binding complex|NCBP-NIP1 complex|mRNA cap binding complex|CBC Note that this complex can be found in the cytoplasm as well as the nucleus. cellular_component owl:Class
GO:0061720 biolink:NamedThing 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA). got7fsn_ti dph 2015-07-01T08:47:30Z biological_process owl:Class
GO:1902777 biolink:NamedThing 6-sulfoquinovose(1-) catabolic process The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-). got7fsn_ti 6-sulfoquinovose(1-) degradation|6-sulfoquinovose(1-) breakdown|6-sulfoquinovose(1-) catabolism dph 2014-03-18T17:46:03Z biological_process owl:Class
GO:0098822 biolink:NamedThing peptidyl-cysteine modification to L-cysteine persulfide The modification of peptidyl-cysteine to form peptidyl-L-cysteine persulfide. got7fsn_ti RESID:AA0269 biological_process owl:Class
GO:0035496 biolink:NamedThing lipopolysaccharide-1,5-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide. got7fsn_ti UDP-D-galactose:(glucosyl)lipopolysaccharide-1,5-D-galactosyltransferase|LPS-1,5-galactosyltransferase activity bf 2010-04-26T03:00:21Z molecular_function owl:Class
GO:0019825 biolink:NamedThing oxygen binding Binding to oxygen (O2). got7fsn_ti cytochrome P450|cytochrome P450 activity molecular_function owl:Class
GO:0000298 biolink:NamedThing endopolyphosphatase activity Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. got7fsn_ti polyphosphate polyphosphohydrolase activity|polyphosphate depolymerase activity|polyphosphatase activity|metaphosphatase activity|polymetaphosphatase activity RHEA:22452|MetaCyc:ENDOPOLYPHOSPHATASE-RXN|EC:3.6.1.10 molecular_function owl:Class
GO:0102569 biolink:NamedThing FR-33289 synthase activity Catalysis of the reaction: FR-900098 + 2-oxoglutarate(2-) + O2 <=> FR-33289 + succinate(2-) + carbon dioxide. got7fsn_ti MetaCyc:RXN-15082 molecular_function owl:Class
GO:0018389 biolink:NamedThing N-terminal peptidyl-valine deamination The deamination of the N-terminal valine residue of a protein to form isobutyrate. got7fsn_ti biological_process owl:Class
GO:0030419 biolink:NamedThing nicotianamine catabolic process The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. got7fsn_ti nicotianamine degradation|nicotianamine catabolism|nicotianamine breakdown biological_process owl:Class
GO:0022828 biolink:NamedThing phosphorylation-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts. got7fsn_ti molecular_function owl:Class
GO:0002453 biolink:NamedThing peripheral B cell anergy Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells. got7fsn_ti peripheral B-lymphocyte anergy|peripheral B lymphocyte anergy|peripheral B-cell anergy biological_process owl:Class
GO:0002515 biolink:NamedThing B cell anergy Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction. got7fsn_ti B-cell anergy|B-lymphocyte anergy|B lymphocyte anergy biological_process owl:Class
GO:0021681 biolink:NamedThing cerebellar granular layer development The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. got7fsn_ti biological_process owl:Class
GO:0030252 biolink:NamedThing growth hormone secretion The regulated release of growth hormone from secretory granules into the blood. got7fsn_ti somatotropin secretion biological_process owl:Class
GO:0033968 biolink:NamedThing glutaryl-7-aminocephalosporanic-acid acylase activity Catalysis of the reaction: (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate. got7fsn_ti glutaryl-7-aminocephalosporanic acid acylase activity|(7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase activity|glutaryl-7-ACA acylase activity|GCA|CA|GA|GL-7-ACA acylase activity|cephalosporin C acylase activity|7beta-(4-carboxybutanamido)cephalosporanic acid acylase activity|cephalosporin acylase activity RHEA:23508|MetaCyc:3.5.1.93-RXN|EC:3.5.1.93 molecular_function owl:Class
GO:0008876 biolink:NamedThing quinoprotein glucose dehydrogenase activity Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol. got7fsn_ti glucose dehydrogenase (pyrroloquinoline-quinone) activity|D-glucose:ubiquinone oxidoreductase activity|quinoprotein D-glucose dehydrogenase activity|glucose dehydrogenase (PQQ-dependent) activity|D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity Formerly EC:1.1.99.17. EC:1.1.5.2|MetaCyc:GLUCDEHYDROG-RXN|RHEA:22152 molecular_function owl:Class
GO:0007136 biolink:NamedThing meiotic prophase II The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0001161 biolink:NamedThing intronic transcription regulatory region sequence-specific DNA binding Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within. got7fsn_ti intronic transcription regulatory region DNA binding https://github.com/geneontology/go-ontology/issues/19312 To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. krc 2011-01-28T03:44:02Z GO:0044213 molecular_function owl:Class
GO:0034222 biolink:NamedThing regulation of cell wall chitin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin in a cell wall. got7fsn_ti regulation of cell wall chitin metabolism biological_process owl:Class
GO:0018734 biolink:NamedThing butyrolactone hydrolase activity Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate. got7fsn_ti UM-BBD_reactionID:r0016 molecular_function owl:Class
GO:0071087 biolink:NamedThing alpha11-beta1 integrin-collagen type I complex A protein complex that consists of an alpha11-beta1 integrin complex bound to a type I collagen. got7fsn_ti ITGA11-ITGB1-COL1A1 complex mah 2009-11-06T04:45:27Z cellular_component owl:Class
GO:0046835 biolink:NamedThing carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. got7fsn_ti biological_process owl:Class
GO:0007475 biolink:NamedThing apposition of dorsal and ventral imaginal disc-derived wing surfaces The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing. got7fsn_ti apposition of dorsal and ventral wing surfaces biological_process owl:Class
GO:0009635 biolink:NamedThing response to herbicide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants. got7fsn_ti herbicide susceptibility/resistance biological_process owl:Class
GO:0047633 biolink:NamedThing agmatine kinase activity Catalysis of the reaction: agmatine + ATP = N(4)-phosphoagmatine + ADP + 3 H(+). got7fsn_ti phosphagen phosphokinase activity|ATP:agmatine 4-N-phosphotransferase activity|ATP:agmatine N4-phosphotransferase activity EC:2.7.3.10|RHEA:15953|MetaCyc:AGMATINE-KINASE-RXN|KEGG_REACTION:R01417 molecular_function owl:Class
GO:0032453 biolink:NamedThing histone H3-methyl-lysine-4 demethylase activity Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein. got7fsn_ti histone H3K4 demethylase activity|histone demethylase activity (H3-K4 specific) https://github.com/geneontology/go-ontology/issues/21089 molecular_function owl:Class
GO:0102224 biolink:NamedThing GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose hydrolase/2-epimerase activity Catalysis of the reaction: GDP-2,4-diacetamido-2,4,6-trideoxy-alpha-D-glucopyranose + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + GDP + H+. got7fsn_ti RHEA:46316|MetaCyc:RXN-12236 molecular_function owl:Class
GO:0072277 biolink:NamedThing metanephric glomerular capillary formation The process that gives rise to a metanephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti mah 2010-04-01T02:47:56Z biological_process owl:Class
GO:0072104 biolink:NamedThing glomerular capillary formation The process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti mah 2010-02-10T02:40:40Z biological_process owl:Class
GO:0031876 biolink:NamedThing secretin receptor binding Binding to a secretin receptor. got7fsn_ti secretin receptor ligand molecular_function owl:Class
GO:0016942 biolink:NamedThing insulin-like growth factor binding protein complex A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development. got7fsn_ti IGF binding protein complex cellular_component owl:Class
GO:0036454 biolink:NamedThing growth factor complex A protein complex that has growth factor activity. got7fsn_ti bf 2013-11-07T11:27:16Z cellular_component owl:Class
GO:0090432 biolink:NamedThing myristoyl-CoA ligase activity Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA. got7fsn_ti myristoyl-CoA synthetase activity tb 2012-07-25T03:31:31Z molecular_function owl:Class
GO:0018695 biolink:NamedThing 4-cresol dehydrogenase (hydroxylating) activity Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor. got7fsn_ti p-cresol methylhydroxylase activity|4-cresol dehydrogenase activity|p-cresol-(acceptor) oxidoreductase (hydroxylating) activity|4-cresol:acceptor oxidoreductase (methyl-hydroxylating) UM-BBD_reactionID:r0272|EC:1.17.9.1|MetaCyc:1.17.99.1-RXN|RHEA:15141 molecular_function owl:Class
GO:0002389 biolink:NamedThing tolerance induction in Peyer's patch Tolerance induction taking place in the Peyer's patches. got7fsn_ti biological_process owl:Class
GO:0030274 biolink:NamedThing LIM domain binding Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. got7fsn_ti molecular_function owl:Class
GO:0033736 biolink:NamedThing L-lysine 6-oxidase activity Catalysis of the reaction: L-lysine + H(2)O + O(2) = allysine + H(2)O(2) + NH(4)(+). got7fsn_ti marinocine|L-lysine-epsilon-oxidase activity|L-lysine:oxygen 6-oxidoreductase (deaminating) activity|LodA|Lod RHEA:22548|EC:1.4.3.20|KEGG_REACTION:R07598|MetaCyc:1.4.3.20-RXN molecular_function owl:Class
GO:0098778 biolink:NamedThing curli subunit secretion coupled to curli assembly The secretion of soluble curli subunits through the outer membrane, coupled to nucleation of curli fiber formation at the membrane surface. got7fsn_ti extracellular nucleation-precipitation pathway biological_process owl:Class
GO:0005952 biolink:NamedThing cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. got7fsn_ti PKA|adenosine 3',5'-cyclophosphate-dependent protein kinase complex|3',5'-cAMP-dependent protein kinase complex|cyclic AMP-dependent protein kinase complex|3',5' cAMP-dependent protein kinase complex cellular_component owl:Class
GO:0070500 biolink:NamedThing poly-gamma-glutamate metabolic process The chemical reactions and pathways involving poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds. got7fsn_ti poly-gamma-glutamate metabolism biological_process owl:Class
GO:0051722 biolink:NamedThing protein C-terminal methylesterase activity Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. got7fsn_ti protein phosphatase methylesterase activity Reactome:R-HSA-8856951 molecular_function owl:Class
GO:0060319 biolink:NamedThing primitive erythrocyte differentiation Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis. got7fsn_ti primitive erythropoiesis|primitive RBC differentiation|primitive red blood cell differentiation biological_process owl:Class
GO:0072075 biolink:NamedThing metanephric mesenchyme development The biological process whose specific outcome is the progression of a metanephric mesenchyme from an initial condition to its mature state. This process begins with the formation of metanephric mesenchyme and ends with the mature structure. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros. got7fsn_ti mah 2010-01-25T04:40:11Z biological_process owl:Class
GO:0008043 biolink:NamedThing intracellular ferritin complex A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains. got7fsn_ti cellular_component owl:Class
GO:0070288 biolink:NamedThing ferritin complex A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain. got7fsn_ti cellular_component owl:Class
GO:0008285 biolink:NamedThing negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation. got7fsn_ti down regulation of cell proliferation|negative regulation of cell proliferation|downregulation of cell proliferation|inhibition of cell proliferation|down-regulation of cell proliferation biological_process owl:Class
GO:0043369 biolink:NamedThing CD4-positive or CD8-positive, alpha-beta T cell lineage commitment The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells. got7fsn_ti CD4-positive or CD8-positive, alpha-beta T-lymphocyte lineage commitment|CD4-positive or CD8-positive, alpha-beta T lymphocyte lineage commitment|CD4-positive or CD8-positive, alpha-beta T-cell lineage commitment|CD4-positive/CD8-positive, alpha-beta T cell lineage commitment biological_process owl:Class
GO:0010669 biolink:NamedThing epithelial structure maintenance A tissue homeostatic process required for the maintenance of epithelial structure. got7fsn_ti biological_process owl:Class
GO:0006883 biolink:NamedThing cellular sodium ion homeostasis Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. got7fsn_ti biological_process owl:Class
GO:0030004 biolink:NamedThing cellular monovalent inorganic cation homeostasis Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell. got7fsn_ti biological_process owl:Class
GO:0002312 biolink:NamedThing B cell activation involved in immune response The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti B cell activation during immune response|B lymphocyte activation during immune response|B-cell activation during immune response|B-lymphocyte activation during immune response biological_process owl:Class
GO:0002285 biolink:NamedThing lymphocyte activation involved in immune response A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. got7fsn_ti lymphocyte activation during immune response biological_process owl:Class
GO:0019249 biolink:NamedThing lactate biosynthetic process The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid. got7fsn_ti lactate formation|lactate biosynthesis|lactate synthesis|lactate anabolism biological_process owl:Class
GO:0000434 biolink:NamedThing carbon catabolite repression of transcription from RNA polymerase II promoter by galactose Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. got7fsn_ti inhibition of transcription from RNA polymerase II promoter by galactose|down-regulation of transcription from RNA polymerase II promoter by galactose|downregulation of transcription from RNA polymerase II promoter by galactose|down regulation of transcription from RNA polymerase II promoter by galactose biological_process owl:Class
GO:0000437 biolink:NamedThing carbon catabolite repression of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. got7fsn_ti negative regulation of transcription from RNA polymerase II promoter by carbon catabolites biological_process owl:Class
GO:0019395 biolink:NamedThing fatty acid oxidation The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. got7fsn_ti MetaCyc:FAO-PWY biological_process owl:Class
GO:0006631 biolink:NamedThing fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. got7fsn_ti fatty acid metabolism Wikipedia:Fatty_acid_metabolism biological_process owl:Class
GO:0018563 biolink:NamedThing 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate. got7fsn_ti UM-BBD_reactionID:r0310|EC:1.13.11.- molecular_function owl:Class
GO:0042069 biolink:NamedThing regulation of catecholamine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines. got7fsn_ti regulation of catecholamine metabolism biological_process owl:Class
GO:0102860 biolink:NamedThing 1-18:1-2-18:2-phosphatidylcholine synthase activity Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:1-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8327|EC:1.14.19.22 molecular_function owl:Class
GO:0032145 biolink:NamedThing succinate-semialdehyde dehydrogenase binding Binding to succinate-semialdehyde dehydrogenase. got7fsn_ti succinic semialdehyde dehydrogenase binding molecular_function owl:Class
GO:0080154 biolink:NamedThing regulation of fertilization Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). got7fsn_ti dhl 2010-09-01T03:44:27Z biological_process owl:Class
GO:0002683 biolink:NamedThing negative regulation of immune system process Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process. got7fsn_ti inhibition of immune system process|down regulation of immune system process|downregulation of immune system process|down-regulation of immune system process biological_process owl:Class
GO:0042857 biolink:NamedThing chrysobactin metabolic process The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). got7fsn_ti chrysobactin metabolism biological_process owl:Class
GO:0031676 biolink:NamedThing plasma membrane-derived thylakoid membrane The pigmented membrane of a plasma membrane-derived thylakoid. got7fsn_ti plasma membrane thylakoid membrane cellular_component owl:Class
GO:0042651 biolink:NamedThing thylakoid membrane The pigmented membrane of any thylakoid. got7fsn_ti cellular_component owl:Class
GO:0018101 biolink:NamedThing protein citrullination The hydrolysis of peptidyl-arginine to form peptidyl-citrulline. got7fsn_ti peptidyl-citrulline synthesis from peptidyl-arginine|deimination|peptidyl-citrulline biosynthetic process from peptidyl-arginine|peptidyl-citrulline anabolism from peptidyl-arginine|peptidyl-citrulline formation from peptidyl-arginine Citrullination is distinct from the formation of the free amino acid citrulline (e.g. as part of the urea cycle). RESID:AA0214 biological_process owl:Class
GO:0021779 biolink:NamedThing oligodendrocyte cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte. got7fsn_ti biological_process owl:Class
GO:0034951 biolink:NamedThing o-hydroxylaminobenzoate mutase activity Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate. got7fsn_ti MetaCyc:RXN-8846|UM-BBD_reactionID:r1026|EC:5.4.99.- molecular_function owl:Class
GO:0061371 biolink:NamedThing determination of heart left/right asymmetry Determination of the asymmetric location of the heart with respect to the left and right halves of the organism. got7fsn_ti determination of cardiac left/right asymmetry dph 2010-11-03T02:13:58Z biological_process owl:Class
GO:0001999 biolink:NamedThing renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure The physiological response of the kidneys to a decrease in blood flow. got7fsn_ti renal response to blood flow during renin-angiotensin control of blood pressure biological_process owl:Class
GO:0033856 biolink:NamedThing pyridoxine 5'-phosphate synthase activity Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = 2 H(2)O + H(+) + phosphate + pyridoxine 5'-phosphate. got7fsn_ti PNP synthase activity|pyridoxine 5-phosphate phospho lyase activity|1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing) activity RHEA:15265|EC:2.6.99.2|MetaCyc:PDXJ-RXN|KEGG_REACTION:R05838 molecular_function owl:Class
GO:0016769 biolink:NamedThing transferase activity, transferring nitrogenous groups Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring other nitrogenous groups EC:2.6.-.- molecular_function owl:Class
GO:0033432 biolink:NamedThing CGG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CGG codon. got7fsn_ti arginine tRNA Note that in the standard genetic code, CGG codes for arginine. molecular_function owl:Class
GO:0044487 biolink:NamedThing envenomation resulting in modulation of transmission of nerve impulse in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism. got7fsn_ti envenomation resulting in modulation of conduction of nerve impulse in other organism jl 2012-01-26T05:01:54Z biological_process owl:Class
GO:0033540 biolink:NamedThing fatty acid beta-oxidation using acyl-CoA oxidase A fatty acid beta-oxidation pathway in which the initial step, which converts an acyl-CoA to a trans-2-enoyl-CoA, is catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti MetaCyc:PWY-5136 biological_process owl:Class
GO:0046150 biolink:NamedThing melanin catabolic process The chemical reactions and pathways resulting in the breakdown of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. got7fsn_ti melanin catabolism|melanin breakdown|melanin degradation biological_process owl:Class
GO:0017071 biolink:NamedThing intracellular cyclic nucleotide activated cation channel complex A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts. got7fsn_ti cellular_component owl:Class
GO:0035142 biolink:NamedThing dorsal fin morphogenesis The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. got7fsn_ti biological_process owl:Class
GO:0043969 biolink:NamedThing histone H2B acetylation The modification of histone H2B by the addition of an acetyl group. got7fsn_ti biological_process owl:Class
GO:0016573 biolink:NamedThing histone acetylation The modification of a histone by the addition of an acetyl group. got7fsn_ti biological_process owl:Class
GO:0071786 biolink:NamedThing endoplasmic reticulum tubular network organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section. got7fsn_ti ER tubular network organisation|ER tubular network organization|endoplasmic reticulum tubular network organisation mah 2010-09-01T01:53:51Z biological_process owl:Class
GO:0019655 biolink:NamedThing glycolytic fermentation to ethanol The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose. got7fsn_ti ethanol fermentation|alcoholic fermentation|glucose fermentation to ethanol|glucose catabolic process to ethanol Wikipedia:Ethanol_fermentation biological_process owl:Class
GO:1990794 biolink:NamedThing basolateral part of cell The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells. got7fsn_ti sl 2015-07-09T20:31:50Z cellular_component owl:Class
GO:0002408 biolink:NamedThing myeloid dendritic cell chemotaxis The movement of a myeloid dendritic cell in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0002407 biolink:NamedThing dendritic cell chemotaxis The movement of a dendritic cell in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0004061 biolink:NamedThing arylformamidase activity Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. got7fsn_ti formamidase II|kynurenine formamidase activity|formylase activity|aryl-formylamine amidohydrolase activity|formylkynureninase activity|formylkynurenine formamidase activity|formamidase I EC:3.5.1.9|MetaCyc:ARYLFORMAMIDASE-RXN|Reactome:R-HSA-71189|RHEA:13009 molecular_function owl:Class
GO:0004055 biolink:NamedThing argininosuccinate synthase activity Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. got7fsn_ti arginine succinate synthetase activity|arginosuccinate synthetase activity|argininosuccinic acid synthetase activity|L-citrulline:L-aspartate ligase (AMP-forming)|argininosuccinate synthetase activity|citrulline--aspartate ligase activity RHEA:10932|Reactome:R-HSA-70577|EC:6.3.4.5|MetaCyc:ARGSUCCINSYN-RXN molecular_function owl:Class
GO:0021600 biolink:NamedThing abducens nerve structural organization The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. got7fsn_ti abducens nerve structural organisation|CN VI structural organization biological_process owl:Class
GO:0043482 biolink:NamedThing cellular pigment accumulation The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus. got7fsn_ti biological_process owl:Class
GO:0001677 biolink:NamedThing formation of translation initiation ternary complex Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). got7fsn_ti translation initiation ternary complex assembly biological_process owl:Class
GO:0002165 biolink:NamedThing instar larval or pupal development The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0019465 biolink:NamedThing aspartate transamidation The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group. got7fsn_ti MetaCyc:ASPARTATE-DEG1-PWY|MetaCyc:ASPARTATESYN-PWY biological_process owl:Class
GO:0006533 biolink:NamedThing aspartate catabolic process The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. got7fsn_ti aspartate catabolism|aspartate degradation|aspartate breakdown biological_process owl:Class
GO:0003408 biolink:NamedThing optic cup formation involved in camera-type eye development The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle. got7fsn_ti dph 2009-12-21T02:37:12Z biological_process owl:Class
GO:0042324 biolink:NamedThing hypocretin receptor binding Binding to a hypocretin receptor. got7fsn_ti orexin receptor binding|hypocretin receptor ligand|orexin receptor ligand molecular_function owl:Class
GO:0070258 biolink:NamedThing inner membrane pellicle complex A membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell. got7fsn_ti inner membrane complex cellular_component owl:Class
GO:0071964 biolink:NamedThing establishment of cell polarity regulating cell shape Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell. got7fsn_ti mah 2011-06-22T03:10:08Z biological_process owl:Class
GO:0106223 biolink:NamedThing germacrene A hydroxylase activity Catalysis of the reaction:(+)-(R)-germacrene A + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = germacra-1(10),4,11(13)-trien-12-oate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. got7fsn_ti germacrene A alcohol dehydrogenase activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.1.1.314. hjd 2019-09-06T16:36:25Z GO:0102260 EC:1.14.14.95|RHEA:30303|MetaCyc:RXN-12449 molecular_function owl:Class
GO:0032041 biolink:NamedThing NAD-dependent histone deacetylase activity (H3-K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. got7fsn_ti EC:3.5.1.98 molecular_function owl:Class
GO:0017136 biolink:NamedThing NAD-dependent histone deacetylase activity Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. got7fsn_ti SIR2 molecular_function owl:Class
GO:0034870 biolink:NamedThing pinacolone 5-monooxygenase activity Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one. got7fsn_ti UM-BBD_reactionID:r12979 molecular_function owl:Class
GO:0047404 biolink:NamedThing glucuronosyl-disulfoglucosamine glucuronidase activity Catalysis of the reaction: H2O + 3-D-glucuronosyl-N2-,6-disulfo-beta-D-glucosamine = glucuronate + N2,6-disulfo-D-glucosamine. got7fsn_ti glucuronosyl-disulphoglucosamine glucuronidase activity|3-D-glucuronsyl-N2,6-disulfo-beta-D-glucosamine glucuronohydrolase activity|3-D-glucuronsyl-2-N,6-disulfo-beta-D-glucosamine glucuronohydrolase activity RHEA:15073|EC:3.2.1.56|MetaCyc:3.2.1.56-RXN molecular_function owl:Class
GO:0051744 biolink:NamedThing 3,8-divinyl protochlorophyllide a 8-vinyl reductase activity Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+. got7fsn_ti RHEA:48884|MetaCyc:RXN1F-72 molecular_function owl:Class
GO:0050354 biolink:NamedThing triokinase activity Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+). got7fsn_ti ATP:D-glyceraldehyde 3-phosphotransferase activity|triose kinase activity|D-triokinase activity|trio triose kinase (phosphorylating) Reactome:R-HSA-70349|RHEA:13941|EC:2.7.1.28|MetaCyc:TRIOKINASE-RXN|KEGG_REACTION:R01059 molecular_function owl:Class
GO:0033773 biolink:NamedThing isoflavone 2'-hydroxylase activity Catalysis of the reaction: an isoflavone + O2 + reduced [NADPH-hemoprotein reductase] = a 2'-hydroxyisoflavone + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. got7fsn_ti CYP81E1|CYP Ge-3|isoflavone 2'-monooxygenase activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.14.13.89. MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN|RHEA:18849|EC:1.14.14.90 molecular_function owl:Class
GO:0004072 biolink:NamedThing aspartate kinase activity Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+). got7fsn_ti beta-aspartokinase activity|ATP:L-aspartate 4-phosphotransferase activity|aspartokinase activity|aspartic kinase activity KEGG_REACTION:R00480|MetaCyc:ASPARTATEKIN-RXN|EC:2.7.2.4|RHEA:23776 molecular_function owl:Class
GO:0047124 biolink:NamedThing L-erythro-3,5-diaminohexanoate dehydrogenase activity Catalysis of the reaction: (3S,5S)-3,5-diaminohexanoate + H(2)O + NAD(+) = (S)-5-amino-3-oxo-hexanoate + H(+) + NADH + NH(4)(+). got7fsn_ti L-erythro-3,5-diaminohexanoate:NAD+ oxidoreductase (deaminating)|L-3,5-diaminohexanoate dehydrogenase activity EC:1.4.1.11|MetaCyc:1.4.1.11-RXN|KEGG_REACTION:R03349|RHEA:19633 molecular_function owl:Class
GO:0010451 biolink:NamedThing floral meristem growth The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower. got7fsn_ti biological_process owl:Class
GO:0060291 biolink:NamedThing long-term synaptic potentiation A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. got7fsn_ti LTP|long-term potentiation biological_process owl:Class
GO:0098731 biolink:NamedThing skeletal muscle satellite stem cell maintenance involved in skeletal muscle regeneration Any process by which the number of skeletal muscle satellite stem cells in a skeletal muscle is maintained during skeletal muscle regeneration. There are at least two mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. got7fsn_ti biological_process owl:Class
GO:0032386 biolink:NamedThing regulation of intracellular transport Any process that modulates the frequency, rate or extent of the directed movement of substances within cells. got7fsn_ti biological_process owl:Class
GO:0103090 biolink:NamedThing methylthiohexylmalate dehydrogenase activity Catalysis of the reaction: 3-(6'-methylthio)hexylmalate <=> H+ + 2-oxo-9-methylthiononanoate + carbon dioxide. got7fsn_ti MetaCyc:RXNQT-4174 molecular_function owl:Class
GO:0005687 biolink:NamedThing U4 snRNP A ribonucleoprotein complex that contains small nuclear RNA U4, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4 snRNP, most of which remain associated with the U4 snRNA both while the U4 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. got7fsn_ti snRNP U4 cellular_component owl:Class
GO:0006892 biolink:NamedThing post-Golgi vesicle-mediated transport The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles. got7fsn_ti post-Golgi transport biological_process owl:Class
GO:0014729 biolink:NamedThing regulation of the velocity of shortening of skeletal muscle modulating contraction Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres. got7fsn_ti regulation of the velocity of shortening of skeletal muscle during contraction biological_process owl:Class
GO:0033269 biolink:NamedThing internode region of axon An axon part that is located between the nodes of Ranvier and surrounded by compact myelin sheath. got7fsn_ti internode NIF_Subcellular:sao206157942 cellular_component owl:Class
GO:0047001 biolink:NamedThing 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity Catalysis of the reaction: NAD+ + 2-dehydro-3-deoxy-D-gluconate = NADH + (4S)-4,6-dihydroxy-2,5-dioxohexanoate. got7fsn_ti 2-dehydro-3-deoxy-D-gluconate:NAD+ 5-oxidoreductase activity|2-keto-3-deoxy-D-gluconate (3-deoxy-D-glycero-2,5-hexodiulosonic acid) dehydrogenase activity|2-keto-3-deoxygluconate dehydrogenase activity|2-keto-3-deoxygluconate 5-dehydrogenase activity|2-keto-3-deoxygluconate (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity MetaCyc:1.1.1.127-RXN|EC:1.1.1.127|RHEA:24232 molecular_function owl:Class
GO:0102887 biolink:NamedThing beta-sesquiphellandrene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-sesquiphellandrene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8430|EC:4.2.3.123|RHEA:32699 molecular_function owl:Class
GO:0070120 biolink:NamedThing ciliary neurotrophic factor-mediated signaling pathway A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti ciliary neurotrophic factor-mediated signalling pathway|CNTF-mediated signaling pathway biological_process owl:Class
GO:0047310 biolink:NamedThing glutamine-scyllo-inositol transaminase activity Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate. got7fsn_ti glutamine--scyllo-inosose aminotransferase activity|glutamine-scyllo-inosose transaminase activity|glutamine-scyllo-inosose aminotransferase activity|glutamine scyllo-inosose aminotransferase activity|glutamine--scyllo-inosose transaminase activity|L-glutamine-keto-scyllo-inositol aminotransferase activity|L-glutamine:2,4,6/3,5-pentahydroxycyclohexanone aminotransferase activity|L-glutamine-scyllo-inosose transaminase activity KEGG_REACTION:R02781|RHEA:22920|EC:2.6.1.50|MetaCyc:2.6.1.50-RXN molecular_function owl:Class
GO:0002253 biolink:NamedThing activation of immune response Any process that initiates an immune response. got7fsn_ti biological_process owl:Class
GO:0060749 biolink:NamedThing mammary gland alveolus development The progression of the mammary gland alveolus over time, from its formation to its mature state. The mammary gland alveolus is a sac-like structure that is found in the mature gland. got7fsn_ti dph 2009-06-22T10:52:12Z biological_process owl:Class
GO:0090378 biolink:NamedThing seed trichome elongation The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell. got7fsn_ti The increase in length of the seed trichome without cell division. Elongation is defined to be from 5 to 20 DPA in Gossypium spp. tb 2010-09-15T02:20:47Z biological_process owl:Class
GO:0015882 biolink:NamedThing L-ascorbic acid transmembrane transport The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. got7fsn_ti vitamin C transport|L-ascorbate transport|L-ascorbic acid transport biological_process owl:Class
GO:0106375 biolink:NamedThing deoxynucleoside triphosphate hydrolase activity Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate. got7fsn_ti hjd 2021-04-15T20:44:33Z RHEA:46148 molecular_function owl:Class
GO:0016793 biolink:NamedThing triphosphoric monoester hydrolase activity Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. got7fsn_ti EC:3.1.5.-|Reactome:R-HSA-8866601 molecular_function owl:Class
GO:0080182 biolink:NamedThing histone H3-K4 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone. got7fsn_ti dhl 2011-08-10T04:18:36Z biological_process owl:Class
GO:0009439 biolink:NamedThing cyanate metabolic process The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid. got7fsn_ti cyanate metabolism MetaCyc:CYANCAT-PWY biological_process owl:Class
GO:0008020 biolink:NamedThing G protein-coupled photoreceptor activity Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G protein coupled photoreceptor activity|G-protein coupled photoreceptor activity|photoreceptor activity, G-protein coupled GO:0004975 molecular_function owl:Class
GO:0097612 biolink:NamedThing dinoflagellate sulcus A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell. got7fsn_ti longitudinal furrow|longitudinal groove|sulcus The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side). pr 2014-06-09T11:31:05Z cellular_component owl:Class
GO:0035995 biolink:NamedThing detection of muscle stretch The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal. got7fsn_ti bf 2011-08-30T01:53:35Z biological_process owl:Class
GO:0042797 biolink:NamedThing tRNA transcription by RNA polymerase III The synthesis of transfer RNA (tRNA) from a DNA template by RNA polymerase III (Pol III), originating at a Pol III promoter. got7fsn_ti tRNA transcription from Pol III promoter|tRNA transcription from RNA polymerase III promoter https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0006383 biolink:NamedThing transcription by RNA polymerase III The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter. got7fsn_ti transcription from RNA polymerase III type 3 promoter|transcription from RNA polymerase III type 2 promoter|transcription from Pol III promoter|transcription from RNA polymerase III promoter|U6 snRNA transcription (mammalian)|U2 snRNA transcription (S. cerevisiae)|transcription from a RNA polymerase III hybrid type promoter|RNA polymerase III transcription factor activity https://github.com/geneontology/go-ontology/issues/14854|https://github.com/geneontology/go-ontology/issues/9617 krc 2010-08-18T06:37:56Z GO:0001035|GO:0001009|GO:0001041 biological_process owl:Class
GO:0045519 biolink:NamedThing interleukin-23 receptor binding Binding to an interleukin-23 receptor. got7fsn_ti interleukin-23 receptor ligand|IL-23 molecular_function owl:Class
GO:0021664 biolink:NamedThing rhombomere 5 morphogenesis The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0047696 biolink:NamedThing beta-adrenergic receptor kinase activity Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor. got7fsn_ti beta-adrenergic receptor-specific kinase activity|GRK2|adrenergic receptor kinase activity|STK15|BARK1|betaARK1|beta2ARK|beta-adrenergic-receptor kinase activity|beta-ARK 1|beta-adrenoceptor kinase activity|beta-adrenoceptor kinase 2 activity|beta-adrenergic-receptor kinase (phosphorylating) activity|beta-AR kinase activity|beta-adrenoceptor kinase 1 activity|beta-receptor kinase activity|[b-adrenergic-receptor] kinase activity|ADRBK1|beta-ARK 2|ATP:beta-adrenergic-receptor phosphotransferase activity|GRK3|beta-ARK RHEA:19429|EC:2.7.11.15|Reactome:R-HSA-8866268|Reactome:R-HSA-8851797 molecular_function owl:Class
GO:0021764 biolink:NamedThing amygdala development The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure. got7fsn_ti biological_process owl:Class
GO:0031972 biolink:NamedThing chloroplast intermembrane space The region between the inner and outer lipid bilayers of a chloroplast envelope. got7fsn_ti chloroplast envelope lumen cellular_component owl:Class
GO:0009529 biolink:NamedThing plastid intermembrane space The region between the inner and outer lipid bilayers of the plastid envelope. got7fsn_ti plastid envelope lumen cellular_component owl:Class
GO:0102507 biolink:NamedThing cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + 4-hydroxybenzoic acid + H+. got7fsn_ti MetaCyc:RXN-14434|EC:2.4.1.300 molecular_function owl:Class
GO:0030099 biolink:NamedThing myeloid cell differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages. got7fsn_ti biological_process owl:Class
GO:0102147 biolink:NamedThing 3'-O-methyltricetin O methyl transferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3'-O-methyltricetin = H+ + S-adenosyl-L-homocysteine + 3',5'-di-O-methyltricetin. got7fsn_ti RHEA:27497|MetaCyc:RXN-11583 molecular_function owl:Class
GO:0003945 biolink:NamedThing N-acetyllactosamine synthase activity Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. got7fsn_ti acetyllactosamine synthetase activity|beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity|lactose synthetase A protein|beta-1,4-GalT|N-acetylglucosamine (beta-1,4)galactosyltransferase activity|UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity|uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity|UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity|N-acetyllactosamine synthetase activity|UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity|UDP-galactose-N-acetylglucosamine galactosyltransferase activity|beta-1,4-galactosyltransferase activity|NAL synthetase activity|beta-(1,4)-galactosyltransferase activity|Gal-T|UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity|UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity|lactosamine synthetase activity|N-acetylglucosamine beta-(1,4)-galactosyltransferase activity|UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity|UDP-beta-1,4-galactosyltransferase activity|UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity|UDP-galactose-acetylglucosamine galactosyltransferase activity|lactosamine synthase activity|UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity|UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN|EC:2.4.1.90|RHEA:17745 molecular_function owl:Class
GO:0032267 biolink:NamedThing tRNA(Ile)-lysidine synthase activity Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine. got7fsn_ti tRNA(Ile)-2-lysyl-cytidine synthase activity|tRNA(Ile)-lysidine synthetase activity EC:6.3.4.- molecular_function owl:Class
GO:0080124 biolink:NamedThing pheophytinase activity Catalysis of the reaction: pheophytin + H2O = phytol + pheophorbide. got7fsn_ti pheophytin pheophorbide hydrolase activity dhl 2009-04-28T04:16:11Z molecular_function owl:Class
GO:0004831 biolink:NamedThing tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). got7fsn_ti L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity|tyrosine translase activity|tyrosine-transfer RNA ligase activity|tyrosyl-tRNA ligase activity|tyrosyl-tRNA synthetase activity|tyrosyl-transfer RNA synthetase activity|tyrosine-transfer ribonucleate synthetase activity|L-tyrosine-tRNATyr ligase (AMP-forming)|tyrosine tRNA synthetase activity|tyrosyl-transfer ribonucleic acid synthetase activity|tyrosyl-transfer ribonucleate synthetase activity|L-tyrosine:tRNATyr ligase (AMP-forming) Reactome:R-HSA-379980|EC:6.1.1.1|RHEA:10220|Reactome:R-HSA-380170|MetaCyc:TYROSINE--TRNA-LIGASE-RXN|KEGG_REACTION:R02918 molecular_function owl:Class
GO:0060737 biolink:NamedThing prostate gland morphogenetic growth The differential increase in size or mass of the prostate gland that contributes to the gland attaining its form. got7fsn_ti prostate gland growth involved in morphogenesis dph 2009-06-15T09:24:40Z biological_process owl:Class
GO:0045515 biolink:NamedThing interleukin-18 receptor binding Binding to an interleukin-18 receptor. got7fsn_ti interleukin-18 receptor ligand|IL-18 molecular_function owl:Class
GO:0047648 biolink:NamedThing alkylamidase activity Catalysis of the reaction: N-methylhexanamide + H(2)O = hexanoate + methylammonium. got7fsn_ti N-methylhexanamide amidohydrolase activity EC:3.5.1.39|KEGG_REACTION:R03620|RHEA:20081|MetaCyc:ALKYLAMIDASE-RXN molecular_function owl:Class
GO:0007314 biolink:NamedThing oocyte anterior/posterior axis specification Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte anterior/posterior axis determination GO:0048112 biological_process owl:Class
GO:0008265 biolink:NamedThing Mo-molybdopterin cofactor sulfurase activity Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase. got7fsn_ti molybdopterin synthase sulfurylase activity|Mo-molybdopterin cofactor sulphurase activity|molybdopterin cofactor sulfurase activity EC:2.8.1.9|Reactome:R-HSA-947499 molecular_function owl:Class
GO:0017017 biolink:NamedThing MAP kinase tyrosine/serine/threonine phosphatase activity Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. got7fsn_ti dual-specificity MAP kinase phosphatase activity molecular_function owl:Class
GO:0052112 biolink:NamedThing occlusion by symbiont of host xylem The process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0052110 biolink:NamedThing occlusion by symbiont of host vascular system The process in which an organism reduces the flow of fluid within its host's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0071358 biolink:NamedThing cellular response to type III interferon Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far. got7fsn_ti cellular response to type III IFN|cellular response to interferon-lambda mah 2009-12-11T02:52:00Z biological_process owl:Class
GO:0039722 biolink:NamedThing suppression by virus of host toll-like receptor signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism. got7fsn_ti inhibition of host TLR pathway by virus|suppression by virus of host TLR signaling pathway bf 2014-01-06T11:39:58Z biological_process owl:Class
GO:0071987 biolink:NamedThing WD40-repeat domain binding Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain. got7fsn_ti WD domain binding|beta-transducin repeat domain binding mah 2010-10-22T02:53:29Z molecular_function owl:Class
GO:0070645 biolink:NamedThing Ubisch body A small, granular structure that is found in the extracellular matrix of cell of the secretory tapetal layer that surrounds developing pollen grains. Ubisch bodies have a sporopollenin coat, are attached to the peritapetal wall, and may play a role in pollen development. got7fsn_ti orbicule mah 2009-05-11T11:35:33Z cellular_component owl:Class
GO:0003855 biolink:NamedThing 3-dehydroquinate dehydratase activity Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O. got7fsn_ti 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)|dehydroquinate dehydratase activity|5-dehydroquinase activity|5-dehydroquinate dehydratase activity|5-dehydroquinate hydro-lyase activity|3-dehydroquinate hydro-lyase activity|3-dehydroquinate hydrolase activity|DHQase|3-dehydroquinase activity|dehydroquinase activity EC:4.2.1.10|KEGG_REACTION:R03084|MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN|RHEA:21096 molecular_function owl:Class
GO:2000643 biolink:NamedThing positive regulation of early endosome to late endosome transport Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport. got7fsn_ti vk 2011-04-21T11:20:09Z biological_process owl:Class
GO:0048522 biolink:NamedThing positive regulation of cellular process Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. got7fsn_ti up-regulation of cellular process|positive regulation of cellular physiological process|upregulation of cellular process|activation of cellular process|up regulation of cellular process|stimulation of cellular process GO:0051242 biological_process owl:Class
GO:0048245 biolink:NamedThing eosinophil chemotaxis The movement of an eosinophil in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0006306 biolink:NamedThing DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. got7fsn_ti Wikipedia:DNA_methylation biological_process owl:Class
GO:0030903 biolink:NamedThing notochord development The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. got7fsn_ti biological_process owl:Class
GO:0005230 biolink:NamedThing extracellular ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti molecular_function owl:Class
GO:0044198 biolink:NamedThing zf-TRAF domain binding Binding to a TRAF-type zinc finger domain of a protein. got7fsn_ti zinc finger TRAF-type domain binding|TRAF-type zinc finger domain binding|zinc-finger-TRAF domain binding jl 2009-10-20T04:09:08Z molecular_function owl:Class
GO:0038099 biolink:NamedThing nodal receptor complex assembly The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals). got7fsn_ti ActRIIB.ALK4.EGF-CFC complex formation|nodal receptor complex formation bf 2012-02-17T11:16:40Z biological_process owl:Class
GO:0060788 biolink:NamedThing ectodermal placode formation The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. got7fsn_ti dph 2009-08-04T12:15:57Z biological_process owl:Class
GO:0061688 biolink:NamedThing glycolytic process via Entner-Doudoroff Pathway A glycolytic process in which the glucose is catabolized to pyruvate by first entering the Entner-Doudoroff pathway to yield pyruvate and glyceraldehyde-3-phosphate. The glyceraldehyde-3-phosphate is subsequently converted to pyruvate by the core glycolytic enzymes. got7fsn_ti gluconate pathway dph 2015-03-12T14:39:00Z biological_process owl:Class
GO:0006096 biolink:NamedThing glycolytic process The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. got7fsn_ti Embden-Meyerhof-Parnas pathway|glycolysis|anaerobic glycolysis|modifed Embden-Meyerhof pathway|Embden-Meyerhof pathway GO:0019641|GO:0019642 MetaCyc:GLYCOLYSIS-VARIANTS biological_process owl:Class
GO:0140494 biolink:NamedThing migrasome A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration. got7fsn_ti pg 2020-07-10T15:09:40Z cellular_component owl:Class
GO:0008913 biolink:NamedThing lauroyltransferase activity Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another. got7fsn_ti lauroyl transferase activity molecular_function owl:Class
GO:0097083 biolink:NamedThing vascular associated smooth muscle cell fate determination The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. got7fsn_ti vascular smooth muscle cell fate determination pr 2011-06-20T04:00:28Z biological_process owl:Class
GO:0007521 biolink:NamedThing muscle cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0070515 biolink:NamedThing alphaIIb-beta3 integrin-talin complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to talin. got7fsn_ti ITGA2b-ITGB3-TLN1 complex cellular_component owl:Class
GO:0016749 biolink:NamedThing N-succinyltransferase activity Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0008972 biolink:NamedThing phosphomethylpyrimidine kinase activity Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. got7fsn_ti hydroxymethylpyrimidine phosphokinase activity|ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity EC:2.7.4.7|RHEA:19893|MetaCyc:PYRIMSYN3-RXN molecular_function owl:Class
GO:0038164 biolink:NamedThing thrombopoietin receptor activity Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti bf 2012-05-14T02:46:58Z molecular_function owl:Class
GO:0052761 biolink:NamedThing exo-1,4-beta-D-glucosaminidase activity Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units. got7fsn_ti chitosan glucosaminohydrolase activity|exo-beta-D-glucosaminidase activity|exochitosanase activity|chitosan exo-1,4-beta-D-glucosaminidase activity ai 2011-09-28T03:30:54Z KEGG_REACTION:R08715|MetaCyc:3.2.1.165-RXN|EC:3.2.1.165 molecular_function owl:Class
GO:0061847 biolink:NamedThing response to cholecystokinin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus. got7fsn_ti biological_process owl:Class
GO:0043434 biolink:NamedThing response to peptide hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. got7fsn_ti response to peptide hormone stimulus|response to polypeptide hormone stimulus biological_process owl:Class
GO:0003957 biolink:NamedThing NAD(P)+ transhydrogenase (B-specific) activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+. got7fsn_ti nicotinamide nucleotide transhydrogenase activity|NADH transhydrogenase|NADPH-NAD oxidoreductase|NADH-NADP-transhydrogenase|pyridine nucleotide transferase|non-energy-linked transhydrogenase activity|NAD(P) transhydrogenase (B-specific) activity|NADPH:NAD+ transhydrogenase|nicotinamide adenine dinucleotide (phosphate) transhydrogenase|H+-thase|NADPH-NAD transhydrogenase|NADPH:NAD+ oxidoreductase (B-specific)|pyridine nucleotide transhydrogenase activity|NAD transhydrogenase MetaCyc:PYRNUTRANSHYDROGEN-RXN|EC:1.6.1.1 molecular_function owl:Class
GO:0015078 biolink:NamedThing proton transmembrane transporter activity Enables the transfer of a proton from one side of a membrane to the other. got7fsn_ti hydrogen ion transmembrane transporter activity|proton transporter activity Reactome:R-HSA-917841|Reactome:R-HSA-74723|Reactome:R-HSA-164834|Reactome:R-HSA-170026|Reactome:R-HSA-1222516 molecular_function owl:Class
GO:0004514 biolink:NamedThing nicotinate-nucleotide diphosphorylase (carboxylating) activity Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate. got7fsn_ti NAD pyrophosphorylase activity|quinolinic acid phosphoribosyltransferase activity|quinolinic phosphoribosyltransferase activity|nicotinate mononucleotide pyrophosphorylase (carboxylating)|nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)|quinolinate phosphoribosyltransferase (decarboxylating) activity|QAPRTase activity|nicotinate-nucleotide pyrophosphorylase (carboxylating) activity RHEA:12733|Reactome:R-HSA-197268|KEGG_REACTION:R03348|EC:2.4.2.19|MetaCyc:QUINOPRIBOTRANS-RXN molecular_function owl:Class
GO:0008586 biolink:NamedThing imaginal disc-derived wing vein morphogenesis The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized. got7fsn_ti wing vein morphogenesis biological_process owl:Class
GO:0072592 biolink:NamedThing oxygen metabolic process The chemical reactions and pathways involving diatomic oxygen (O2). got7fsn_ti oxygen metabolism|diatomic oxygen metabolic process mah 2011-02-11T10:46:51Z biological_process owl:Class
GO:0004372 biolink:NamedThing glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. got7fsn_ti serine transhydroxymethylase activity|serine aldolase activity|serine hydroxymethyltransferase activity|L-serine hydroxymethyltransferase activity|serine hydroxymethylase activity|5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity|allothreonine aldolase activity Reactome:R-HSA-200651|RHEA:15481|Reactome:R-HSA-200735|Reactome:R-HSA-71249|Reactome:R-HSA-5694137|MetaCyc:GLYOHMETRANS-RXN|EC:2.1.2.1 molecular_function owl:Class
GO:0018105 biolink:NamedThing peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. got7fsn_ti RESID:AA0037 biological_process owl:Class
GO:0044185 biolink:NamedThing host cell late endosome membrane The lipid bilayer surrounding a host cell late endosome. got7fsn_ti jl 2009-10-15T03:00:39Z cellular_component owl:Class
GO:1990320 biolink:NamedThing collagen type XXI trimer A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle. got7fsn_ti bhm 2014-03-14T16:40:14Z cellular_component owl:Class
GO:1990267 biolink:NamedThing response to transition metal nanoparticle Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle. got7fsn_ti response to colloidal metal|response to neutral metal atoms sl 2014-01-10T17:16:41Z biological_process owl:Class
GO:0004903 biolink:NamedThing growth hormone receptor activity Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0002131 biolink:NamedThing wobble position cytosine ribose methylation The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. got7fsn_ti biological_process owl:Class
GO:0002130 biolink:NamedThing wobble position ribose methylation The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position. got7fsn_ti biological_process owl:Class
GO:0098770 biolink:NamedThing FBXO family protein binding Binding to a member of the FBXO protein family. Members of this family have an F-box protein motif of approximately 50 amino acids that functions as a site of protein-protein interaction. got7fsn_ti molecular_function owl:Class
GO:0022880 biolink:NamedThing protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti N-acetylglucosamine PTS transporter activity molecular_function owl:Class
GO:0015572 biolink:NamedThing N-acetylglucosamine transmembrane transporter activity Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. got7fsn_ti N-acetylchitosamine transmembrane transporter activity|N-Acetyl-D-glucosamine permease|D-GlcNAc transmembrane transporter activity|N-acetyl-D-glucosamine transmembrane transporter activity|N-acetylglucosamine permease activity GO:0015580 molecular_function owl:Class
GO:0018141 biolink:NamedThing peptide cross-linking via L-lysine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti RESID:AA0245 biological_process owl:Class
GO:0140418 biolink:NamedThing effector-mediated modulation of host process by symbiont A process mediated by a molecule secreted by a symbiont that results in the modulation (either activation or suppresion) of a host structure or process. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti effector-dependent modulation of host process by symbiont|effector mediated modulation of host process by symbiont|effector triggered modulation of host process by symbiont https://github.com/geneontology/go-ontology/issues/20971|https://github.com/geneontology/go-ontology/issues/18605 pg 2020-01-29T21:24:42Z biological_process owl:Class
GO:0007294 biolink:NamedThing germarium-derived oocyte fate determination The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte cell fate determination|maintenance of oocyte identity GO:0016350 biological_process owl:Class
GO:0030716 biolink:NamedThing oocyte fate determination The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti oocyte cell fate determination biological_process owl:Class
GO:0051751 biolink:NamedThing alpha-1,4-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->4) linkage. got7fsn_ti molecular_function owl:Class
GO:0042748 biolink:NamedThing circadian sleep/wake cycle, non-REM sleep All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions. got7fsn_ti biological_process owl:Class
GO:0048283 biolink:NamedThing indeterminate inflorescence morphogenesis The process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems. got7fsn_ti biological_process owl:Class
GO:0071374 biolink:NamedThing cellular response to parathyroid hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. got7fsn_ti mah 2009-12-11T03:19:29Z biological_process owl:Class
GO:0071107 biolink:NamedThing response to parathyroid hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a parathyroid hormone stimulus. got7fsn_ti response to parathyroid hormone stimulus mah 2009-11-12T10:58:45Z biological_process owl:Class
GO:0044238 biolink:NamedThing primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. got7fsn_ti primary metabolism biological_process owl:Class
GO:0003726 biolink:NamedThing double-stranded RNA adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. got7fsn_ti double-stranded RNA specific editase activity GO:0003971 Reactome:R-HSA-77614|Reactome:R-HSA-77615 molecular_function owl:Class
GO:0004000 biolink:NamedThing adenosine deaminase activity Catalysis of the reaction: adenosine + H2O = inosine + NH3. got7fsn_ti adenosine aminohydrolase activity|adenosine deaminase reaction Reactome:R-HSA-2161195|Reactome:R-HSA-2161187|Reactome:R-HSA-74241|RHEA:24408|MetaCyc:ADENODEAMIN-RXN|Reactome:R-HSA-5693346|EC:3.5.4.4 molecular_function owl:Class
GO:0042764 biolink:NamedThing ascospore-type prospore An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi. got7fsn_ti cellular_component owl:Class
GO:0042763 biolink:NamedThing intracellular immature spore A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants. got7fsn_ti forespore cellular_component owl:Class
GO:0031670 biolink:NamedThing cellular response to nutrient Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus. got7fsn_ti biological_process owl:Class
GO:0007604 biolink:NamedThing phototransduction, UV The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers. got7fsn_ti UV-sensitive opsin|phototransduction, ultraviolet radiation|phototransduction, UV light|phototransduction, UV radiation|phototransduction, ultraviolet light biological_process owl:Class
GO:1901512 biolink:NamedThing (-)-microperfuranone biosynthetic process The chemical reactions and pathways resulting in the formation of (-)-microperfuranone. got7fsn_ti (-)-microperfuranone synthesis|(-)-microperfuranone biosynthesis|(-)-microperfuranone anabolism|(-)-microperfuranone formation di 2012-10-18T06:54:18Z biological_process owl:Class
GO:1901503 biolink:NamedThing ether biosynthetic process The chemical reactions and pathways resulting in the formation of ether. got7fsn_ti ether biosynthesis|ether formation|ether synthesis|ether anabolism pr 2012-10-17T09:42:47Z biological_process owl:Class
GO:0046217 biolink:NamedThing indole phytoalexin metabolic process The chemical reactions and pathways involving indole phytoalexins, any indole compound produced by plants as part of their defense response. got7fsn_ti indole phytoalexin metabolism biological_process owl:Class
GO:0052314 biolink:NamedThing phytoalexin metabolic process The chemical reactions and pathways involving phytoalexins, any of a range of substances produced by plants as part of their defense response. got7fsn_ti phytoalexin metabolism biological_process owl:Class
GO:0097660 biolink:NamedThing SCF-Cdc4 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Cdc4 in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:23:13Z cellular_component owl:Class
GO:2000382 biolink:NamedThing positive regulation of mesoderm development Any process that activates or increases the frequency, rate or extent of mesoderm development. got7fsn_ti vk 2011-02-15T03:10:12Z biological_process owl:Class
GO:2000380 biolink:NamedThing regulation of mesoderm development Any process that modulates the frequency, rate or extent of mesoderm development. got7fsn_ti vk 2011-02-15T03:09:46Z biological_process owl:Class
GO:0085037 biolink:NamedThing extrahaustorial membrane The membrane surrounding the symbiont haustorium during symbiosis, derived from the host plasma membrane. got7fsn_ti See also: haustorium ; GO:0085035 and extrahaustorial matrix ; GO:0085036. jl 2010-07-27T04:00:49Z cellular_component owl:Class
GO:0071011 biolink:NamedThing precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. got7fsn_ti mammalian spliceosomal complex B|yeast spliceosomal complex A2-1|mammalian spliceosomal complex B1 mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:2000946 biolink:NamedThing negative regulation of amylopectin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin catabolic process. got7fsn_ti negative regulation of Amylopectin catabolism tt 2011-08-01T02:15:27Z biological_process owl:Class
GO:2000882 biolink:NamedThing negative regulation of starch catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of starch catabolic process. got7fsn_ti negative regulation of starch degradation|negative regulation of starch catabolism|negative regulation of starch breakdown bf 2011-07-27T03:23:46Z biological_process owl:Class
GO:0022011 biolink:NamedThing myelination in peripheral nervous system The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. got7fsn_ti peripheral nervous system myelination biological_process owl:Class
GO:0042552 biolink:NamedThing myelination The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. got7fsn_ti myelinogenesis Wikipedia:Myelin biological_process owl:Class
GO:0034899 biolink:NamedThing trimethylamine monooxygenase activity Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O. got7fsn_ti KEGG_REACTION:R05623|UM-BBD_reactionID:r1407|EC:1.14.13.148|RHEA:31979 molecular_function owl:Class
GO:0106211 biolink:NamedThing inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate. got7fsn_ti 5-PP-InsP4 activity|5-diphospho-myo-inositol 1,3,4,6-tetrakisphosphate diphosphatase activity|5-diphosphoinositol 1,3,4,6-tetrakisphosphate diphosphatase activity hjd 2019-06-06T19:26:38Z RHEA:59500 molecular_function owl:Class
GO:0052840 biolink:NamedThing inositol diphosphate tetrakisphosphate diphosphatase activity Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate. got7fsn_ti ai 2011-11-29T04:14:22Z MetaCyc:RXN-10963|EC:3.6.1.52|Reactome:R-HSA-1855166 molecular_function owl:Class
GO:0106314 biolink:NamedThing nitrite reductase NADPH activity Catalysis of the reaction: ammonium hydroxide + 3 NADP+ + H2O = nitrite + 3 NADPH + 3 H+. got7fsn_ti hjd 2020-09-23T14:28:27Z RHEA:24632 molecular_function owl:Class
GO:0008942 biolink:NamedThing nitrite reductase [NAD(P)H] activity Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+. got7fsn_ti nitrite reductase [NAD(P)H2]|nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity|NAD(P)H2:nitrite oxidoreductase activity|NADPH-nitrite reductase activity|NAD(P)H:nitrite oxidoreductase activity|assimilatory nitrite reductase activity|ammonium-hydroxide:NAD(P)+ oxidoreductase activity|NADH-nitrite oxidoreductase activity Note that this function was formerly EC:1.6.6.4. MetaCyc:NITRITREDUCT-RXN|EC:1.7.1.4|KEGG_REACTION:R00789|KEGG_REACTION:R00787 molecular_function owl:Class
GO:0033373 biolink:NamedThing maintenance of protease location in mast cell secretory granule A process in which a protease is maintained in a secretory granule in a mast cell and prevented from moving elsewhere. got7fsn_ti maintenance of protease localization in mast cell secretory granule|mast cell protease retention biological_process owl:Class
GO:0033370 biolink:NamedThing maintenance of protein location in mast cell secretory granule A process in which a protein is maintained in a secretory granule in a mast cell and prevented from moving elsewhere. got7fsn_ti mast cell protein retention|maintenance of protein localization in mast cell secretory granule biological_process owl:Class
GO:0052690 biolink:NamedThing trichloro-p-hydroquinone reductive dehalogenase activity Catalysis of the reaction: 2,3,6-trichlorohydroquinone + 2 glutathione = 2,6-dichlorohydroquinone + glutathione disulfide + HCl. got7fsn_ti trichlorohydroquinone reductive dehalogenase activity|pentaerythritol tetranitrate reductase activity|tetrachlorohydroquinone reductive dehalogenase activity|xenobiotic reductase activity UM-BBD_reactionID:r0315|RHEA:56832 molecular_function owl:Class
GO:0002824 biolink:NamedThing positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. got7fsn_ti biological_process owl:Class
GO:0003221 biolink:NamedThing right ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized. got7fsn_ti right ventricle myocardium morphogenesis dph 2009-10-13T10:26:33Z biological_process owl:Class
GO:0055010 biolink:NamedThing ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac ventricle muscle is generated and organized. got7fsn_ti cardiac ventricle muscle morphogenesis|ventricular heart muscle morphogenesis biological_process owl:Class
GO:0102428 biolink:NamedThing kaempferol-3-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-alpha-D-glucose <=> kaempferol-3-gentiobioside + UDP. got7fsn_ti MetaCyc:RXN-13830 molecular_function owl:Class
GO:0003796 biolink:NamedThing lysozyme activity Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. got7fsn_ti N,O-diacetylmuramidase activity|peptidoglycan N-acetylmuramoylhydrolase activity|1,4-N-acetylmuramidase activity|L-7001|muramidase activity|mucopeptide N-acetylmuramoylhydrolase activity|PR1-lysozyme|globulin G|globulin G1|lysozyme g|mucopeptide glucohydrolase activity MetaCyc:3.2.1.17-RXN|Reactome:R-HSA-8862320|EC:3.2.1.17 molecular_function owl:Class
GO:0018829 biolink:NamedThing 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. got7fsn_ti DDD dehydrochlorinase activity EC:4.5.1.-|UM-BBD_reactionID:r0513 molecular_function owl:Class
GO:0016848 biolink:NamedThing carbon-halide lyase activity Catalysis of the breakage of a bond between carbon and any halogen atom. got7fsn_ti EC:4.5.-.- molecular_function owl:Class
GO:0010583 biolink:NamedThing response to cyclopentenone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid. got7fsn_ti biological_process owl:Class
GO:0060488 biolink:NamedThing orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis The process in which a lung bud bifurcates perpendicular to the plane of the previous bud. got7fsn_ti perpendicular dichotomous subdivision of terminal units involved in lung branching morphogenesis biological_process owl:Class
GO:0007195 biolink:NamedThing adenylate cyclase-inhibiting dopamine receptor signaling pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti dopamine receptor, adenylate cyclase inhibiting pathway|inhibition of adenylate cyclase activity by dopamine receptor signalling pathway|dopamine receptor, adenylyl cyclase inhibiting pathway|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway biological_process owl:Class
GO:0061299 biolink:NamedThing retina vasculature morphogenesis in camera-type eye The process in which the vasculature of the retina is generated and organized. got7fsn_ti retinal vasculature morphogenesis dph 2010-09-06T03:28:25Z biological_process owl:Class
GO:0031864 biolink:NamedThing EP1 subtype prostaglandin E2 receptor binding Binding to an EP1 subtype prostaglandin E2 receptor. got7fsn_ti prostanoid EP1 receptor binding|EP1 subtype prostaglandin E2 receptor ligand molecular_function owl:Class
GO:0002093 biolink:NamedThing auditory receptor cell morphogenesis Any process that alters the size or shape of an auditory receptor cell. got7fsn_ti hair cell morphogenesis biological_process owl:Class
GO:0102534 biolink:NamedThing apigenin-7,4'-dimethyl ether 6-hydroxylase activity Catalysis of the reaction: apigenin-7,4'-dimethyl ether + O2 + NADPH + H+ <=> ladanein + H2O + NADP. got7fsn_ti MetaCyc:RXN-14751 molecular_function owl:Class
GO:0033713 biolink:NamedThing choline:oxygen 1-oxidoreductase activity Catalysis of the reaction: choline + O2 = betaine aldehyde + hydrogen peroxide. got7fsn_ti choline oxidase activity RHEA:13505|MetaCyc:CHOLINE-OXIDASE-RXN|EC:1.1.3.17 molecular_function owl:Class
GO:0000054 biolink:NamedThing ribosomal subunit export from nucleus The directed movement of a ribosomal subunit from the nucleus into the cytoplasm. got7fsn_ti ribosomal subunit transport from nucleus to cytoplasm|ribosomal subunit-nucleus export|ribosome export from nucleus|ribosomal subunit export out of nucleus|ribosomal subunit export from cell nucleus biological_process owl:Class
GO:0036260 biolink:NamedThing RNA capping The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts. got7fsn_ti bf 2012-06-15T02:10:23Z biological_process owl:Class
GO:0004931 biolink:NamedThing extracellularly ATP-gated cation channel activity Enables the transmembrane transfer of a cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. got7fsn_ti purinoceptor|purinoreceptor|P2X receptor Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'. Reactome:R-HSA-877187 molecular_function owl:Class
GO:0035381 biolink:NamedThing ATP-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. got7fsn_ti bf 2010-03-18T01:21:45Z molecular_function owl:Class
GO:0048373 biolink:NamedThing lateral mesodermal cell fate determination The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti lateral plate mesodermal cell fate determination|lateral mesoderm cell fate determination|lateral plate mesoderm cell fate determination biological_process owl:Class
GO:0031607 biolink:NamedThing nuclear proteasome core complex, beta-subunit complex The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell. got7fsn_ti cellular_component owl:Class
GO:0052096 biolink:NamedThing formation of syncytium involving giant cell for nutrient acquisition The assembly of a syncytium, a multi-nucleate and physiologically active aggregation of fused root cells induced by a symbiotic nematode in a plant host. The syncytium exclusively provides the nematode with nourishment during its sedentary life, for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti formation by symbiont of syncytium involving giant cell for nutrient acquisition from host|formation by organism of syncytium involving giant cell for nutrient acquisition from host https://github.com/geneontology/go-ontology/issues/20305 biological_process owl:Class
GO:0052093 biolink:NamedThing formation of specialized structure for nutrient acquisition The assembly of a symbiotic cellular or anatomical structure for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti formation by organism of specialized structure for nutrient acquisition from host|formation of specialized structure for nutrient acquisition from host|formation by symbiont of specialized structure for nutrient acquisition from host https://github.com/geneontology/go-ontology/issues/20305 biological_process owl:Class
GO:0018641 biolink:NamedThing 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. got7fsn_ti UM-BBD_reactionID:r0048|EC:1.14.13.- molecular_function owl:Class
GO:1902577 biolink:NamedThing protein localization to medial cortical node A process in which a protein is transported to, or maintained in, a location within a medial cortical node. got7fsn_ti protein localisation to medial cortical node|protein localisation in medial cortical node|protein localization in medial cortical node mah 2013-12-17T14:09:28Z biological_process owl:Class
GO:0052819 biolink:NamedThing heteroglycan 2-alpha-mannosyltransferase activity Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP. got7fsn_ti GDP mannose 2-alpha-mannosyltransferase activity|heteropolysaccharide 2-alpha-mannosyltransferase activity|GDP-mannose:heteroglycan 2-alpha-D-mannosyltransferase activity|guanosine diphosphomannose-heteroglycan 2-alpha-mannosyltransferase activity ai 2011-10-27T12:36:19Z KEGG_REACTION:R03768|MetaCyc:2.4.1.48-RXN|EC:2.4.1.48 molecular_function owl:Class
GO:0047264 biolink:NamedThing heteroglycan alpha-mannosyltransferase activity Catalysis of the reaction: heteroglycan + GDP-mannose = alpha-D-mannosylheteroglycan + GDP. got7fsn_ti GDP-mannose:heteroglycan 2-(or 3-)-alpha-D-mannosyltransferase activity|heteropolysaccharide alpha-mannosyltransferase activity|GDP mannose alpha-mannosyltransferase activity|guanosine diphosphomannose-heteroglycan alpha-mannosyltransferase activity EC:2.4.1.48 molecular_function owl:Class
GO:0008388 biolink:NamedThing testosterone 15-alpha-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O. got7fsn_ti cytochrome P450 CYP2A4 molecular_function owl:Class
GO:0032348 biolink:NamedThing negative regulation of aldosterone biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. got7fsn_ti inhibition of aldosterone biosynthetic process|down-regulation of aldosterone biosynthetic process|downregulation of aldosterone biosynthetic process|down regulation of aldosterone biosynthetic process biological_process owl:Class
GO:0032345 biolink:NamedThing negative regulation of aldosterone metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. got7fsn_ti down regulation of aldosterone metabolic process|inhibition of aldosterone metabolic process|downregulation of aldosterone metabolic process|down-regulation of aldosterone metabolic process|negative regulation of aldosterone metabolism biological_process owl:Class
GO:0004409 biolink:NamedThing homoaconitate hydratase activity Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O. got7fsn_ti homoaconitase activity|(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]|2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity|Lys4|LysF|cis-homoaconitase activity|HACN activity KEGG_REACTION:R04371|MetaCyc:HOMOACONITATE-HYDRATASE-RXN|RHEA:15485|EC:4.2.1.36 molecular_function owl:Class
GO:0097505 biolink:NamedThing Rad6-Rad18 complex A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity. got7fsn_ti pr 2013-09-26T13:42:58Z cellular_component owl:Class
GO:0103096 biolink:NamedThing CYP79F1 dihomomethionine monooxygenase activity Catalysis of the reaction: dihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 5-methylthiopentanaldoxime + 3 H2O + carbon dioxide + 2 NADP. got7fsn_ti MetaCyc:RXNQT-4309|RHEA:32719 molecular_function owl:Class
GO:0004581 biolink:NamedThing dolichyl-phosphate beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate. got7fsn_ti polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity|UDP-glucose:dolichyl phosphate glucosyltransferase activity|UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity|UDP-glucose:dolichyl monophosphate glucosyltransferase activity|UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity|uridine diphosphoglucose-dolichol glucosyltransferase activity|UDP-glucose dolichyl-phosphate glucosyltransferase activity|UDP-glucose:dolicholphosphoryl glucosyltransferase activity|UDP-glucose:dolichol phosphate glucosyltransferase activity MetaCyc:2.4.1.117-RXN|RHEA:15401|Reactome:R-HSA-446214|EC:2.4.1.117 molecular_function owl:Class
GO:0035815 biolink:NamedThing positive regulation of renal sodium excretion Any process that increases the amount of sodium excreted in urine over a unit of time. got7fsn_ti natriuresis The amount of sodium excreted in urine over a unit of time can be increased by increasing the volume of urine produced (diuresis) and/or by increasing the concentration of sodium in the urine. bf 2011-04-20T01:29:26Z biological_process owl:Class
GO:0047966 biolink:NamedThing glycosulfatase activity Catalysis of the reaction: D-glucose 6-sulfate + H(2)O = D-glucose + H(+) + sulfate. got7fsn_ti glucosulfatase activity|sugar-sulfate sulfohydrolase activity|glycosulphatase activity KEGG_REACTION:R00534|EC:3.1.6.3|MetaCyc:GLYCOSULFATASE-RXN|RHEA:19145 molecular_function owl:Class
GO:0038153 biolink:NamedThing CCL2-activated CCR4 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CCL2/CCR4 signaling pathway bf 2012-05-11T11:44:48Z biological_process owl:Class
GO:0038148 biolink:NamedThing chemokine (C-C motif) ligand 2 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CCL2 signaling pathway bf 2012-05-11T11:36:08Z biological_process owl:Class
GO:0030330 biolink:NamedThing DNA damage response, signal transduction by p53 class mediator A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage. got7fsn_ti p53 signaling pathway|TP53 signaling pathway|p53-mediated DNA damage response|DNA damage response, activation of p53 GO:0006976 biological_process owl:Class
GO:0097708 biolink:NamedThing intracellular vesicle Any vesicle that is part of the intracellular region. got7fsn_ti pr 2016-03-29T17:39:45Z cellular_component owl:Class
GO:0002475 biolink:NamedThing antigen processing and presentation via MHC class Ib The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. got7fsn_ti biological_process owl:Class
GO:0018084 biolink:NamedThing peptidyl-lactic acid biosynthetic process from peptidyl-serine The modification of N-terminal peptidyl-serine to lactic acid. got7fsn_ti peptidyl-lactic acid formation from peptidyl-serine|peptidyl-lactic acid anabolism from peptidyl-serine|peptidyl-lactic acid synthesis from peptidyl-serine RESID:AA0186 biological_process owl:Class
GO:0102544 biolink:NamedThing ornaline synthase activity Catalysis of the reaction: L-ornithinium(1+) + 2-oxoglutarate + NADPH + H+ <=> ornaline + NADP + H2O. got7fsn_ti MetaCyc:RXN-14880 molecular_function owl:Class
GO:0032455 biolink:NamedThing nerve growth factor processing The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor. got7fsn_ti NGF processing|beta-nerve growth factor processing biological_process owl:Class
GO:0039613 biolink:NamedThing suppression by virus of host protein phosphorylation Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host. got7fsn_ti viral inhibition of host protein phosphorylation bf 2012-07-06T11:15:56Z biological_process owl:Class
GO:0033194 biolink:NamedThing response to hydroperoxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. got7fsn_ti biological_process owl:Class
GO:0031099 biolink:NamedThing regeneration The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass). got7fsn_ti Wikipedia:Regeneration_(biology) biological_process owl:Class
GO:0045301 biolink:NamedThing tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin. got7fsn_ti tRNA-(ms2io6A)-hydroxylase activity|tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyladenosine)-hydroxylase activity|2-methylthio-cis-ribozeatin hydroxylase activity molecular_function owl:Class
GO:0047288 biolink:NamedThing monosialoganglioside sialyltransferase activity Catalysis of the reaction: D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP-N-acetylneuraminate = N-acetylneuraminyl-D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide + CMP. got7fsn_ti CMP-N-acetylneuraminate:D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetylneuraminyltransferase activity RHEA:18021|EC:2.4.99.2|MetaCyc:2.4.99.2-RXN molecular_function owl:Class
GO:0050599 biolink:NamedThing deacetoxycephalosporin-C synthase activity Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate. got7fsn_ti deacetoxycephalosporin C synthetase activity|DAOC synthase activity|penicillin N expandase activity|penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding)|DAOCS activity|expandase activity GO:0045441 EC:1.14.20.1|MetaCyc:1.14.20.1-RXN|KEGG_REACTION:R05301|RHEA:20748 molecular_function owl:Class
GO:0004578 biolink:NamedThing chitobiosyldiphosphodolichol beta-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol. got7fsn_ti GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity|guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity|GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity Reactome:R-HSA-446218|RHEA:13865|EC:2.4.1.142|MetaCyc:2.4.1.142-RXN|Reactome:R-HSA-4549382 molecular_function owl:Class
GO:0019187 biolink:NamedThing beta-1,4-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage. got7fsn_ti molecular_function owl:Class
GO:0018491 biolink:NamedThing 2-oxobutyrate synthase activity Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin. got7fsn_ti 2-ketobutyrate synthase activity|alpha-ketobutyrate-ferredoxin oxidoreductase activity|2-oxobutyrate-ferredoxin oxidoreductase activity|2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)|alpha-ketobutyrate synthase activity MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN|UM-BBD_reactionID:r0358|RHEA:32135 molecular_function owl:Class
GO:0007091 biolink:NamedThing metaphase/anaphase transition of mitotic cell cycle The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. got7fsn_ti mitotic metaphase/anaphase transition|metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological_process owl:Class
GO:0010965 biolink:NamedThing regulation of mitotic sister chromatid separation Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis. got7fsn_ti tb 2009-05-20T11:39:07Z biological_process owl:Class
GO:0031989 biolink:NamedThing bombesin receptor signaling pathway The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands. got7fsn_ti bombesin receptor signalling pathway biological_process owl:Class
GO:0030032 biolink:NamedThing lamellipodium assembly Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. got7fsn_ti lamellipodium formation|lamellipodium biogenesis|lamellipodium biosynthesis biological_process owl:Class
GO:0046797 biolink:NamedThing viral procapsid maturation The refolding and structural rearrangements of individual capsid subunits to transition from the intermediate procapsid, to the more stable capsid structure. got7fsn_ti capsid maturation|virion maturation|viral capsid maturation UniProtKB-KW:KW-1273 biological_process owl:Class
GO:0009028 biolink:NamedThing tartronate-semialdehyde synthase activity Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2). got7fsn_ti hydroxymalonic semialdehyde carboxylase activity|glyoxylate carboligase activity|glyoxylate carbo-ligase activity|glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)|tartronic semialdehyde carboxylase activity|tartronate semialdehyde carboxylase activity|glyoxylic carbo-ligase activity|glyoxylate carboxy-lyase (dimerizing)|glyoxalate carboligase activity EC:4.1.1.47|KEGG_REACTION:R00013|RHEA:10136|MetaCyc:GLYOCARBOLIG-RXN molecular_function owl:Class
GO:0072257 biolink:NamedThing metanephric nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the metanephric nephron tubule as it progresses from its formation to the mature state. got7fsn_ti mah 2010-03-19T04:11:02Z biological_process owl:Class
GO:0072160 biolink:NamedThing nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the nephron tubule as it progresses from its formation to the mature state. got7fsn_ti mah 2010-02-24T02:40:11Z biological_process owl:Class
GO:0070447 biolink:NamedThing positive regulation of oligodendrocyte progenitor proliferation Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation. got7fsn_ti positive regulation of oligodendrocyte precursor proliferation biological_process owl:Class
GO:0014015 biolink:NamedThing positive regulation of gliogenesis Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia. got7fsn_ti activation of gliogenesis|up-regulation of gliogenesis|up regulation of gliogenesis|upregulation of gliogenesis|stimulation of gliogenesis biological_process owl:Class
GO:0047302 biolink:NamedThing UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose transaminase activity Catalysis of the reaction: 2-oxoglutarate + UDP-2-acetamido-4-amino-2,4,6-trideoxy-D-glucose = L-glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose. got7fsn_ti UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity|uridine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity|UDP-4-amino-2-acetamido-2,4,6-trideoxyglucose transaminase activity|UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose:2-oxoglutarate aminotransferase activity MetaCyc:2.6.1.34-RXN|EC:2.6.1.34|KEGG_REACTION:R04529|RHEA:31663 molecular_function owl:Class
GO:0039647 biolink:NamedThing suppression by virus of host poly(A)-binding protein activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation. got7fsn_ti inhibition of host poly(A)-binding protein by virus|suppression by virus of host PABP activity bf 2012-10-09T15:14:07Z biological_process owl:Class
GO:0106371 biolink:NamedThing fluorescent chlorophyll catabolite monooxygenase (deformylase) activity Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] = formate + 2 H+ + oxidized [NADPH--hemoprotein reductase] + primary fluorescent dioxobilin-type chlorophyll catabolite. got7fsn_ti hjd 2021-04-01T16:32:56Z molecular_function owl:Class
GO:0032346 biolink:NamedThing positive regulation of aldosterone metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone. got7fsn_ti stimulation of aldosterone metabolic process|positive regulation of aldosterone metabolism|up-regulation of aldosterone metabolic process|upregulation of aldosterone metabolic process|up regulation of aldosterone metabolic process|activation of aldosterone metabolic process biological_process owl:Class
GO:0016740 biolink:NamedThing transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. got7fsn_ti Reactome:R-HSA-8868783|Reactome:R-HSA-1483089|Reactome:R-HSA-5668414|Reactome:R-HSA-1483186|EC:2.-.-.- molecular_function owl:Class
GO:0006776 biolink:NamedThing vitamin A metabolic process The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene. got7fsn_ti vitamin A metabolism biological_process owl:Class
GO:0006775 biolink:NamedThing fat-soluble vitamin metabolic process The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water. got7fsn_ti fat-soluble vitamin metabolism biological_process owl:Class
GO:0051878 biolink:NamedThing lateral element assembly The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements. got7fsn_ti biological_process owl:Class
GO:0102771 biolink:NamedThing sphingolipid very long chain fatty acid alpha-hydroxylase activity Catalysis of the reaction: O2 + NADPH + H+ + a dihydroceramide = NADP + H2O + an alpha hydroxydihydroceramide. got7fsn_ti MetaCyc:RXN-7796|RHEA:46512 molecular_function owl:Class
GO:0035174 biolink:NamedThing histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. got7fsn_ti histone-serine kinase activity molecular_function owl:Class
GO:0003973 biolink:NamedThing (S)-2-hydroxy-acid oxidase activity Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide. got7fsn_ti hydroxyacid oxidase A|very-long-chain-(S)-2-hydroxy-acid oxidase activity|medium-chain-(S)-2-hydroxy-acid oxidase activity|hydroxy-acid oxidase A activity|long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity|L-alpha-hydroxy acid oxidase|glycolate oxidase activity|L-2-hydroxy acid oxidase|hydroxy-acid oxidase B activity https://github.com/geneontology/go-ontology/issues/21795 GO:0052852|GO:0052853|GO:0008891|GO:0052854 MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN|EC:1.1.3.15|Reactome:R-HSA-6787811|Reactome:R-HSA-389842|RHEA:16789|MetaCyc:RXN-969 molecular_function owl:Class
GO:1990726 biolink:NamedThing Lsm1-7-Pat1 complex A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway. got7fsn_ti pr 2015-04-08T09:22:36Z cellular_component owl:Class
GO:0001840 biolink:NamedThing neural plate development The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. got7fsn_ti biological_process owl:Class
GO:1903039 biolink:NamedThing positive regulation of leukocyte cell-cell adhesion Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion. got7fsn_ti up regulation of leukocyte adhesion|activation of leukocyte adhesion|up-regulation of leukocyte adhesion|activation of leukocyte cell adhesion|up regulation of leukocyte cell adhesion|up-regulation of leukocyte cell-cell adhesion|upregulation of leukocyte adhesion|up regulation of leukocyte cell-cell adhesion|activation of leukocyte cell-cell adhesion|upregulation of leukocyte cell-cell adhesion|positive regulation of leukocyte adhesion|up-regulation of leukocyte cell adhesion|upregulation of leukocyte cell adhesion|positive regulation of leukocyte cell adhesion Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion rl 2014-05-19T15:30:15Z biological_process owl:Class
GO:0022409 biolink:NamedThing positive regulation of cell-cell adhesion Any process that activates or increases the rate or extent of cell adhesion to another cell. got7fsn_ti stimulation of cell-cell adhesion|up regulation of cell-cell adhesion|upregulation of cell-cell adhesion|activation of cell-cell adhesion|up-regulation of cell-cell adhesion biological_process owl:Class
GO:0098823 biolink:NamedThing peptidyl-cysteine modification to S-amindino-L-cysteine The amidinylation of peptidyl-cysteine to form peptidyl-S-amidino-L-cysteine. got7fsn_ti RESID:AA0335 biological_process owl:Class
GO:0072596 biolink:NamedThing establishment of protein localization to chloroplast The directed movement of a protein to a specific location in a chloroplast. got7fsn_ti establishment of protein localisation to chloroplast mah 2011-02-14T02:16:13Z biological_process owl:Class
GO:0046544 biolink:NamedThing development of secondary male sexual characteristics The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion. got7fsn_ti biological_process owl:Class
GO:0045136 biolink:NamedThing development of secondary sexual characteristics The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion. got7fsn_ti biological_process owl:Class
GO:0018255 biolink:NamedThing peptide cross-linking via S-glycyl-L-cysteine The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins. got7fsn_ti RESID:AA0206 biological_process owl:Class
GO:0051450 biolink:NamedThing myoblast proliferation The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0098771 biolink:NamedThing inorganic ion homeostasis Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0009627 biolink:NamedThing systemic acquired resistance The salicylic acid mediated response to a pathogen which confers broad spectrum resistance. got7fsn_ti salicylic acid-dependent systemic resistance Wikipedia:Systemic_acquired_resistance biological_process owl:Class
GO:0097275 biolink:NamedThing cellular ammonium homeostasis Any biological process involved in the maintenance of an internal steady state of ammonium at the level of the cell. got7fsn_ti cellular ammonia homeostasis pr 2012-03-22T02:54:38Z biological_process owl:Class
GO:0097272 biolink:NamedThing ammonium homeostasis Any biological process involved in the maintenance of an internal steady state of ammonium. got7fsn_ti ammonia homeostasis pr 2012-03-22T02:51:22Z biological_process owl:Class
GO:0003182 biolink:NamedThing coronary sinus valve morphogenesis The process in which the structure of the coronary sinus valve is generated and organized. got7fsn_ti dph 2009-10-08T11:33:31Z biological_process owl:Class
GO:0048613 biolink:NamedThing embryonic ectodermal digestive tract morphogenesis The process, occurring during the embryonic phase, by which the anatomical structures of the ectodermal digestive tract are generated and organized. got7fsn_ti embryonic ectodermal gut morphogenesis biological_process owl:Class
GO:0061983 biolink:NamedThing meiosis II cell cycle process A process that coontributes to the second meiotic division. The second meiotic division separates chromatids resulting in a haploid number of chromosomes. got7fsn_ti second meiotic division dph 2018-02-14T22:37:44Z biological_process owl:Class
GO:1903046 biolink:NamedThing meiotic cell cycle process A process that is part of the meiotic cell cycle. got7fsn_ti jl 2014-05-22T14:22:28Z biological_process owl:Class
GO:0018052 biolink:NamedThing C-terminal peptidyl-tyrosine amidation The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0099 biological_process owl:Class
GO:0003755 biolink:NamedThing peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). got7fsn_ti peptidyl-prolyl isomerase B reaction|FK506-sensitive peptidyl-prolyl cis-trans isomerase|peptidylprolyl cis-trans isomerase activity|parvulin|peptide bond isomerase activity|peptidylproline cis-trans-isomerase activity|cis-trans proline isomerase activity|peptidylprolyl isomerase activity|juglone-sensitive peptidyl-prolyl cis-trans isomerase activity|immunophilin|PPIase activity|rotamase activity|cyclophilin activity|cyclophilin-type peptidyl-prolyl cis-trans isomerase activity|juglone-sensitive cis-trans proline isomerase activity GO:0042028|GO:0004752 Reactome:R-HSA-2022073|EC:5.2.1.8|Reactome:R-HSA-9626816|MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN|RHEA:16237 molecular_function owl:Class
GO:0045052 biolink:NamedThing protein insertion into ER membrane by GPI attachment sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule. got7fsn_ti protein-ER insertion by GPI attachment sequence|GPI attachment sequence mediated protein insertion into ER membrane|protein insertion into ER membrane, GPI attachment sequence mediated|protein-endoplasmic reticulum insertion by GPI attachment sequence|protein insertion into endoplasmic reticulum membrane by GPI attachment sequence biological_process owl:Class
GO:0090094 biolink:NamedThing metanephric cap mesenchymal cell proliferation involved in metanephros development The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip. got7fsn_ti tb 2009-11-13T10:34:10Z biological_process owl:Class
GO:0010447 biolink:NamedThing response to acidic pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti response to acidity This term should be used to annotate instances where a cell or organism is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0001101 'response to acid chemical'. biological_process owl:Class
GO:0034189 biolink:NamedThing very-low-density lipoprotein particle binding Binding to a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. got7fsn_ti very-low-density lipoprotein binding|VLDL binding molecular_function owl:Class
GO:0014062 biolink:NamedThing regulation of serotonin secretion Any process that modulates the frequency, rate or extent of the regulated release of serotonin. got7fsn_ti regulation of serotonin release biological_process owl:Class
GO:0048669 biolink:NamedThing collateral sprouting in absence of injury The process in which outgrowths develop from the axons of intact undamaged neurons. got7fsn_ti biological_process owl:Class
GO:0070330 biolink:NamedThing aromatase activity Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. got7fsn_ti estrogen synthetase activity RHEA:17149|EC:1.14.14.1|UM-BBD_enzymeID:e0551|MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0102475 biolink:NamedThing 2-hydroxyeriodictyol 6C-glucoside dehydratase activity Catalysis of the reaction: 6C-beta-D-glucosyl-2-hydroxyeriodictyol <=> isoorientin + H2O. got7fsn_ti MetaCyc:RXN-14081 molecular_function owl:Class
GO:0004119 biolink:NamedThing cGMP-inhibited cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. got7fsn_ti molecular_function owl:Class
GO:1990398 biolink:NamedThing Cus cation efflux complex Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth. got7fsn_ti copper efflux complex|copper efflux system|silver efflux system|Cus cation efflux system|silver efflux complex An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209. bhm 2014-06-11T08:51:48Z cellular_component owl:Class
GO:1903113 biolink:NamedThing copper ion transmembrane transporter complex A protein complex which is capable of copper ion transmembrane transporter activity. got7fsn_ti An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:23122209 (inferred from direct assay). bhm 2014-06-10T09:54:48Z cellular_component owl:Class
GO:0047023 biolink:NamedThing androsterone dehydrogenase activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. got7fsn_ti 3(or 17)alpha-hydroxysteroid dehydrogenase activity|3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase activity|3(17)alpha-hydroxysteroid dehydrogenase activity|3(or 17)-alpha-hydroxysteroid dehydrogenase activity EC:1.1.1.209|MetaCyc:1.1.1.209-RXN molecular_function owl:Class
GO:0003249 biolink:NamedThing cell proliferation involved in heart valve morphogenesis The multiplication or reproduction of cells that contributes to the shaping of a heart valve. got7fsn_ti dph 2009-10-13T01:59:19Z biological_process owl:Class
GO:0061323 biolink:NamedThing cell proliferation involved in heart morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart. got7fsn_ti dph 2010-09-28T09:05:26Z biological_process owl:Class
GO:0006553 biolink:NamedThing lysine metabolic process The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid. got7fsn_ti lysine metabolism Wikipedia:Lysine biological_process owl:Class
GO:0009066 biolink:NamedThing aspartate family amino acid metabolic process The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. got7fsn_ti aspartate family amino acid metabolism biological_process owl:Class
GO:0047458 biolink:NamedThing beta-pyrazolylalanine synthase activity Catalysis of the reaction: O-acetyl-L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + acetate + H(+). got7fsn_ti BPA-synthase activity|O3-acetyl-L-serine acetate-lyase (adding pyrazole)|O(3)-acetyl-L-serine acetate-lyase (adding pyrazole) activity|O3-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity|beta-(1-pyrazolyl)alanine synthase activity|beta-pyrazolylalanine synthase (acetylserine) activity|beta-pyrazolealanine synthase activity|3-O-acetyl-L-serine:pyrazole 1-(2-amino-2-carboxyethyl)transferase activity|pyrazolealanine synthase activity|pyrazolylalaninase activity MetaCyc:2.5.1.51-RXN|EC:2.5.1.51|KEGG_REACTION:R03134|RHEA:13117 molecular_function owl:Class
GO:0097161 biolink:NamedThing DH domain binding Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket. got7fsn_ti pr 2011-09-27T10:06:09Z molecular_function owl:Class
GO:0035123 biolink:NamedThing embryonic dorsal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. got7fsn_ti biological_process owl:Class
GO:0102235 biolink:NamedThing 1-penten-3-one reductase activity Catalysis of the reaction: 1-penten-3-one + NADPH + H+ <=> 1-pentan-3-one + NADP. got7fsn_ti MetaCyc:RXN-12295 molecular_function owl:Class
GO:0042054 biolink:NamedThing histone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue. got7fsn_ti histone methylase activity EC:2.1.1.354 molecular_function owl:Class
GO:0006279 biolink:NamedThing premeiotic DNA replication The replication of DNA that precedes meiotic cell division. got7fsn_ti nuclear cell cycle DNA replication involved in meiotic cell cycle|meiotic cell cycle DNA replication|DNA replication during S phase involved in meiotic cell cycle|meiotic DNA replication|premeiotic DNA synthesis|meiotic nuclear cell cycle DNA replication|DNA replication involved in S-phase involved in meiotic cell cycle|meiotic DNA synthesis|DNA replication involved in S phase involved in meiotic cell cycle GO:1902968 biological_process owl:Class
GO:0033260 biolink:NamedThing nuclear DNA replication The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. got7fsn_ti DNA replication involved in S-phase|DNA replication during S phase|nuclear cell cycle DNA replication|DNA replication involved in S phase biological_process owl:Class
GO:0048500 biolink:NamedThing signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. got7fsn_ti Wikipedia:Signal_recognition_particle cellular_component owl:Class
GO:0071125 biolink:NamedThing alphaV-beta3 integrin-EGFR complex A protein complex that consists of an alphaV-beta3 integrin complex bound to epidermal growth factor receptor. got7fsn_ti ITGAV-ITGB3-EGFR complex mah 2009-11-13T02:23:18Z cellular_component owl:Class
GO:0060665 biolink:NamedThing regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling Any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium. got7fsn_ti regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signalling dph 2009-06-01T08:42:36Z biological_process owl:Class
GO:0071626 biolink:NamedThing mastication The process of biting and mashing food with the teeth prior to swallowing. got7fsn_ti chewing mah 2010-02-10T11:19:48Z biological_process owl:Class
GO:0044821 biolink:NamedThing meiotic telomere tethering at nuclear periphery The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle. got7fsn_ti jl 2013-11-19T16:18:09Z biological_process owl:Class
GO:0034398 biolink:NamedThing telomere tethering at nuclear periphery The process in which a telomere is maintained in a specific location at the nuclear periphery. got7fsn_ti biological_process owl:Class
GO:2000846 biolink:NamedThing regulation of corticosteroid hormone secretion Any process that modulates the frequency, rate or extent of corticosteroid hormone secretion. got7fsn_ti regulation of corticosteroid secretion bf 2011-07-26T08:43:38Z biological_process owl:Class
GO:0008962 biolink:NamedThing phosphatidylglycerophosphatase activity Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. got7fsn_ti PGP phosphatase activity|phosphatidylglycerol phosphate phosphatase activity|phosphatidylglycerol phosphatase activity|phosphatidylglycerophosphate phosphohydrolase activity EC:3.1.3.27|MetaCyc:PGPPHOSPHA-RXN|RHEA:16725|Reactome:R-HSA-1483197 molecular_function owl:Class
GO:0021736 biolink:NamedThing globose nucleus development The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0036411 biolink:NamedThing H-NS-Cnu complex A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes. got7fsn_ti bf 2013-08-22T10:19:24Z cellular_component owl:Class
GO:0017053 biolink:NamedThing transcription repressor complex A protein complex that possesses activity that prevents or downregulates transcription. got7fsn_ti nuclear transcriptional repressor complex|transcriptional repressor complex|cytoplasmic transcriptional repressor complex|transcription factor inhibitor complex tb 2014-05-09T13:23:51Z GO:0090568|GO:0090569 cellular_component owl:Class
GO:0106334 biolink:NamedThing 3'-deoxyribose phosphate lyase activity Catalysis of the conversion of a 3'-deoxyribose phosphate in DNA to a 3'-phosphate. got7fsn_ti 3'-dRP lyase activity|3'-dRP lyase hjd 2020-10-20T19:04:24Z molecular_function owl:Class
GO:0097301 biolink:NamedThing regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter Any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter|cellular potassium ion homeostasis by positive regulation of transcription from RNA polymerase II promoter pr 2012-05-09T09:03:02Z biological_process owl:Class
GO:0004097 biolink:NamedThing catechol oxidase activity Catalysis of the reaction: 2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone. This reaction catalyzes exclusively the oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. got7fsn_ti polyphenol oxidase activity|tyrosinase activity|diphenol oxidase activity|pyrocatechol oxidase|L-DOPA monooxygenase activity|L-dopa oxidase activity|phenolase activity|catecholase|dopamine monooxygenase activity|o-diphenol oxidoreductase|o-diphenolase activity https://github.com/geneontology/go-ontology/issues/21024 GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'. GO:0102316|GO:0036264|GO:0036263 MetaCyc:CATECHOL-OXIDASE-RXN|MetaCyc:RXN-13061|EC:1.10.3.1|RHEA:21632 molecular_function owl:Class
GO:0045046 biolink:NamedThing protein import into peroxisome membrane The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import. got7fsn_ti peroxisome membrane protein import|protein transport into peroxisome membrane biological_process owl:Class
GO:0048526 biolink:NamedThing imaginal disc-derived wing expansion The process of expanding or inflating the folded imaginal disc-derived pupal wing, and the adhering of the dorsal and ventral surfaces, to form the mature adult wing. got7fsn_ti wing expansion|wing inflation biological_process owl:Class
GO:0007062 biolink:NamedThing sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. got7fsn_ti sister chromatid alignment|coheson-mediated DNA tethering biological_process owl:Class
GO:0004818 biolink:NamedThing glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). got7fsn_ti L-glutamate:tRNAGlu ligase (AMP-forming) activity|glutamyl-transfer ribonucleic acid synthetase activity|glutamyl-tRNA synthetase activity|glutamic acid translase activity|glutamyl-transfer RNA synthetase activity|glutamyl-transfer ribonucleate synthetase activity|glutamate-tRNA synthetase activity MetaCyc:GLURS-RXN|RHEA:23540|Reactome:R-HSA-380216|EC:6.1.1.17|Reactome:R-HSA-379861 molecular_function owl:Class
GO:0004764 biolink:NamedThing shikimate 3-dehydrogenase (NADP+) activity Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. got7fsn_ti 5-dehydroshikimic reductase activity|shikimate:NADP(+) oxidoreductase activity|shikimate oxidoreductase activity|5-dehydroshikimate reductase activity|shikimate:NADP(+) 5-oxidoreductase activity|DHS reductase activity|dehydroshikimic reductase activity EC:1.1.1.282|RHEA:17737|MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN|EC:1.1.1.25|KEGG_REACTION:R06847 molecular_function owl:Class
GO:0019729 biolink:NamedThing peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. got7fsn_ti biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. RESID:AA0189 biological_process owl:Class
GO:0035789 biolink:NamedThing metanephric mesenchymal cell migration The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros. got7fsn_ti metanephric mesenchyme chemotaxis bf 2011-04-06T10:45:15Z biological_process owl:Class
GO:0035788 biolink:NamedThing cell migration involved in metanephros development The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ. got7fsn_ti cell migration involved in metanephric kidney development bf 2011-04-06T10:42:21Z biological_process owl:Class
GO:0003208 biolink:NamedThing cardiac ventricle morphogenesis The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. got7fsn_ti dph 2009-10-13T09:38:44Z biological_process owl:Class
GO:0033117 biolink:NamedThing esterosome A vesicle filled with crystalline protein that shows sequence similarities with various esterases. got7fsn_ti cellular_component owl:Class
GO:0047038 biolink:NamedThing D-arabinitol 2-dehydrogenase activity Catalysis of the reaction: D-arabinitol + NAD(+) = D-ribulose + H(+) + NADH. got7fsn_ti D-arabinitol 2-dehydrogenase (ribulose-forming) activity|D-arabinitol:NAD+ 2-oxidoreductase (D-ribulose-forming) RHEA:17389|MetaCyc:1.1.1.250-RXN|EC:1.1.1.250|KEGG_REACTION:R07134 molecular_function owl:Class
GO:0019976 biolink:NamedThing interleukin-2 binding Binding to interleukin-2. got7fsn_ti IL-2 binding molecular_function owl:Class
GO:0050565 biolink:NamedThing aerobactin synthase activity Catalysis of the reaction: 2 N(6)-acetyl-N(6)-hydroxy-L-lysine + 4 ATP + citrate + 2 H(2)O = 4 ADP + aerobactin + 8 H(+) + 4 phosphate. got7fsn_ti citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming)|citrate:N6-acetyl-N6-hydroxy-L-lysine ligase (ADP-forming) KEGG_REACTION:R04357|RHEA:11760|MetaCyc:6.3.2.27-RXN molecular_function owl:Class
GO:0047573 biolink:NamedThing 4-acetamidobutyrate deacetylase activity Catalysis of the reaction: 4-acetamidobutanoate + H2O = acetate + 4-aminobutanoate. got7fsn_ti 4-acetamidobutanoate amidohydrolase activity RHEA:15897|EC:3.5.1.63|MetaCyc:4-ACETAMIDOBUTYRATE-DEACETYLASE-RXN molecular_function owl:Class
GO:0008914 biolink:NamedThing leucyltransferase activity Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein. got7fsn_ti leucyl-tRNA--protein transferase activity|leucyl/phenylalanyl-tRNA--protein transferase activity|leucyl, phenylalanine-tRNA-protein transferase activity|leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity|L-leucyl-tRNA:protein leucyltransferase activity|leucyl-phenylalanine-transfer ribonucleate-protein transferase activity|L/F transferase activity EC:2.3.2.6|MetaCyc:LEUCYLTRANSFERASE-RXN|RHEA:12340 molecular_function owl:Class
GO:0102420 biolink:NamedThing sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity Catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate = coenzyme A + 1-C16:0-alpha,omega-dicarboxyl-2-lysophosphatidate. got7fsn_ti MetaCyc:RXN-13805|EC:2.3.1.15 molecular_function owl:Class
GO:0070616 biolink:NamedThing regulation of thiamine diphosphate biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate. got7fsn_ti regulation of thiamine diphosphate biosynthesis|regulation of thiamine diphosphate anabolism|regulation of thiamin diphosphate biosynthetic process|regulation of thiamine diphosphate formation|regulation of thiamine diphosphate synthesis mah 2009-04-29T03:37:35Z biological_process owl:Class
GO:0030656 biolink:NamedThing regulation of vitamin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti regulation of vitamin metabolism biological_process owl:Class
GO:0008782 biolink:NamedThing adenosylhomocysteine nucleosidase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine. got7fsn_ti S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity|S-adenosylhomocysteine hydrolase activity|S-adenosyl-L-homocysteine homocysteinylribohydrolase activity|S-adenosylhomocysteine nucleosidase activity|5'-methyladenosine nucleosidase activity|AdoHcy/MTA nucleosidase activity RHEA:17805|EC:3.2.2.9|MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN molecular_function owl:Class
GO:0021885 biolink:NamedThing forebrain cell migration The orderly movement of a cell from one site to another at least one of which is located in the forebrain. got7fsn_ti biological_process owl:Class
GO:0097002 biolink:NamedThing mitochondrial inner boundary membrane The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane. got7fsn_ti inner bounding mitochondrial membrane pr 2011-03-10T04:11:50Z NIF_Subcellular:sao18461326 cellular_component owl:Class
GO:1990305 biolink:NamedThing RAD6-UBR2 ubiquitin ligase complex A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation. got7fsn_ti RAD6-UBR2 complex This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:15504724 bhm 2014-03-03T22:14:32Z cellular_component owl:Class
GO:0052546 biolink:NamedThing cell wall pectin metabolic process The chemical reactions and pathways involving pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, as part of the organization and biogenesis of the cell wall. got7fsn_ti cell wall pectin metabolism|plant-type cell wall pectin metabolic process|pectin metabolism during cell wall biogenesis|cellulose and pectin-containing cell wall pectin metabolic process biological_process owl:Class
GO:1902694 biolink:NamedThing superoxide dismutase copper chaperone complex A protein complex which is capable of superoxide dismutase copper chaperone activity. got7fsn_ti An example of this is CCS1 in Saccharomyces cerevisiae S288c (UniProt symbol P40202) in PMID:10426947. bhm 2014-02-18T11:13:45Z cellular_component owl:Class
GO:1902695 biolink:NamedThing metallochaperone complex A protein complex which is capable of metallochaperone activity. got7fsn_ti bhm 2014-02-18T11:34:40Z cellular_component owl:Class
GO:0097273 biolink:NamedThing creatinine homeostasis Any biological process involved in the maintenance of an internal steady state of creatinine. got7fsn_ti pr 2012-03-22T02:52:50Z biological_process owl:Class
GO:1990615 biolink:NamedThing Kelch-containing formin regulatory complex A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p. got7fsn_ti Bud14-Kel1-Kel2 complex|KFRC complex mcc 2015-01-21T18:48:51Z cellular_component owl:Class
GO:0043843 biolink:NamedThing ADP-specific glucokinase activity Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate. got7fsn_ti ADP:D-glucose 6-phosphotransferase activity|ADP-dependent glucokinase activity RHEA:11460|Reactome:R-HSA-5696021|EC:2.7.1.147 molecular_function owl:Class
GO:0007277 biolink:NamedThing pole cell development The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0001660 biolink:NamedThing fever generation The heat generation process that results in a rise in body temperature above the normal, often as a response to infection. got7fsn_ti pyrexia Wikipedia:Fever biological_process owl:Class
GO:0031649 biolink:NamedThing heat generation Any homeostatic process in which an organism produces heat, thereby raising its internal temperature. got7fsn_ti biological_process owl:Class
GO:0018011 biolink:NamedThing N-terminal peptidyl-alanine methylation The methylation of the N-terminal alanine of proteins. got7fsn_ti RESID:AA0061|RESID:AA0062 biological_process owl:Class
GO:0098912 biolink:NamedThing membrane depolarization during atrial cardiac muscle cell action potential The process in which atrial cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti electrocardiogram PR interval|atrial cardiac muscle cell depolarization|atrial depolarization biological_process owl:Class
GO:0086012 biolink:NamedThing membrane depolarization during cardiac muscle cell action potential The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti tb 2011-11-10T08:20:33Z biological_process owl:Class
GO:0090031 biolink:NamedThing positive regulation of steroid hormone biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones. got7fsn_ti tb 2009-08-03T10:40:32Z biological_process owl:Class
GO:0044818 biolink:NamedThing mitotic G2/M transition checkpoint A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle. got7fsn_ti jl 2013-11-19T14:20:00Z biological_process owl:Class
GO:0080192 biolink:NamedThing primary thickening Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from the activity of a primary thickening meristem. got7fsn_ti Occurs in shoot axes and rarely in roots in many monocotyledons. dhl 2012-12-06T15:55:18Z biological_process owl:Class
GO:0002766 biolink:NamedThing innate immune response-inhibiting signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response. got7fsn_ti biological_process owl:Class
GO:0002765 biolink:NamedThing immune response-inhibiting signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response. got7fsn_ti biological_process owl:Class
GO:1900799 biolink:NamedThing cordyol C biosynthetic process The chemical reactions and pathways resulting in the formation of cordyol C. got7fsn_ti cordyol C synthesis|cordyol C anabolism|cordyol C biosynthesis|cordyol C formation di 2012-06-04T09:48:17Z biological_process owl:Class
GO:0097591 biolink:NamedThing ventral disc lateral crest Fibrillar repetitive structure surrounding the ventral disc edge in Giardia species (trophozoite stage). The composition of the lateral crest is not fully known yet. got7fsn_ti ventral disk lateral crest|lateral crest Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-04-03T10:47:48Z cellular_component owl:Class
GO:0043711 biolink:NamedThing pilus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. got7fsn_ti pilus organization and biogenesis|pilus organisation Note that this term should not be used for direct annotation. Please use one of the children, GO:0009297 ; pilus assembly or GO:0043108 ; pilus retraction. biological_process owl:Class
GO:0071352 biolink:NamedThing cellular response to interleukin-2 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-2 stimulus. got7fsn_ti cellular response to IL-2 mah 2009-12-11T02:50:48Z biological_process owl:Class
GO:0038134 biolink:NamedThing ERBB2-EGFR signaling pathway A series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. got7fsn_ti EGFR-HER2 signaling pathway|ERBB2-EGFR signalling pathway bf 2012-03-30T11:16:28Z biological_process owl:Class
GO:0038128 biolink:NamedThing ERBB2 signaling pathway A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair. got7fsn_ti receptor tyrosine-protein kinase erbB-2 signaling pathway|HER2 signaling pathway|ERBB2 signalling pathway|NEU signaling bf 2012-03-30T10:05:12Z biological_process owl:Class
GO:0140593 biolink:NamedThing host apoplast The apoplast region surrounding a host plant cell. Plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti host cell apoplast https://github.com/geneontology/go-ontology/issues/21343|https://github.com/geneontology/go-ontology/issues/20814 pg 2021-02-09T18:56:11Z cellular_component owl:Class
GO:0033258 biolink:NamedThing plastid DNA metabolic process The chemical reactions and pathways involving plastid DNA. got7fsn_ti plastid DNA metabolism biological_process owl:Class
GO:0001713 biolink:NamedThing ectodermal cell fate determination The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti ectoderm cell fate determination biological_process owl:Class
GO:0047179 biolink:NamedThing platelet-activating factor acetyltransferase activity Catalysis of the reaction: 1-radyl-2-acyl-sn-glycero-3-phospholipid + 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine = 1-alkyl-2-lyso-sn-glycero-3-phosphocholine + 1-radyl-2-acetyl-sn-glycero-3-phospholipid. got7fsn_ti PAF acetyltransferase activity|1-alkyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phospholipid acetyltransferase activity MetaCyc:2.3.1.149-RXN|RHEA:11048|EC:2.3.1.149 molecular_function owl:Class
GO:0102597 biolink:NamedThing 3alpha-hydroxy-ent-sandaracopimardiene 9-beta-monooxygenase activity Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin E + NADP + H2O. got7fsn_ti EC:1.14.14.122|RHEA:41468|MetaCyc:RXN-15381 molecular_function owl:Class
GO:1990537 biolink:NamedThing mitotic spindle polar microtubule Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone. got7fsn_ti vw 2014-11-14T15:32:38Z cellular_component owl:Class
GO:1990498 biolink:NamedThing mitotic spindle microtubule Any microtubule that is part of a mitotic spindle; anchored at one spindle pole. got7fsn_ti vw 2014-09-26T13:34:40Z cellular_component owl:Class
GO:0008870 biolink:NamedThing galactoside O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside. got7fsn_ti thiogalactoside acetyltransferase activity|acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity|galactoside acetyltransferase activity|thiogalactoside transacetylase activity MetaCyc:GALACTOACETYLTRAN-RXN|EC:2.3.1.18|RHEA:15713 molecular_function owl:Class
GO:0030944 biolink:NamedThing DDEL sequence binding Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. got7fsn_ti molecular_function owl:Class
GO:0046923 biolink:NamedThing ER retention sequence binding Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. got7fsn_ti endoplasmic reticulum retention sequence binding molecular_function owl:Class
GO:0097141 biolink:NamedThing BIM-BCL-2 complex A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:42:31Z cellular_component owl:Class
GO:0061952 biolink:NamedThing midbody abscission The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells. got7fsn_ti cytokinetic abscission|cell separation during cytokinesis dph 2017-11-07T19:44:37Z biological_process owl:Class
GO:0010738 biolink:NamedThing regulation of protein kinase A signaling Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. got7fsn_ti regulation of protein kinase A signaling cascade|regulation of protein kinase A signalling cascade|regulation of PKA signaling cascade biological_process owl:Class
GO:1902531 biolink:NamedThing regulation of intracellular signal transduction Any process that modulates the frequency, rate or extent of intracellular signal transduction. got7fsn_ti regulation of intracellular signaling cascade|regulation of intracellular protein kinase cascade|regulation of signal transduction via intracellular signaling cascade|regulation of intracellular signaling pathway|regulation of intracellular signal transduction pathway|regulation of signal transmission via intracellular cascade|regulation of intracellular signaling chain bf 2013-12-02T11:32:52Z GO:0010627 biological_process owl:Class
GO:0000170 biolink:NamedThing sphingosine hydroxylase activity Catalysis of the hydroxylation of sphingolipid long chain bases. got7fsn_ti Reactome:R-HSA-428260 molecular_function owl:Class
GO:0030585 biolink:NamedThing phosphoenolpyruvate carboxykinase (diphosphate) activity Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate. got7fsn_ti phosphoenolpyruvic carboxykinase (pyrophosphate)|phosphopyruvate carboxylase (pyrophosphate)|phosphoenolpyruvate carboxytransphosphorylase activity|diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)|phosphoenolpyruvate carboxykinase (pyrophosphate) activity|phosphoenolpyruvate carboxyphosphotransferase activity|phosphoenolpyruvate carboxylase (pyrophosphate)|phosphopyruvate carboxykinase|phosphopyruvate carboxykinase (pyrophosphate)|PEP carboxyphosphotransferase activity|phosphoenolpyruvic carboxytransphosphorylase activity|phosphoenolpyruvic carboxylase (pyrophosphate)|PEPCTrP|phosphoenolpyruvic carboxykinase|diphosphate:oxaloacetate carboxy-lyase (transphosphorylating) RHEA:22356|KEGG_REACTION:R00346|MetaCyc:4.1.1.38-RXN|EC:4.1.1.38 molecular_function owl:Class
GO:0060323 biolink:NamedThing head morphogenesis The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body. got7fsn_ti biological_process owl:Class
GO:0032935 biolink:NamedThing sterol sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol. got7fsn_ti sterol-sensing domain molecular_function owl:Class
GO:0032934 biolink:NamedThing sterol binding Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. got7fsn_ti sterol carrier activity GO:0005498 molecular_function owl:Class
GO:0018730 biolink:NamedThing glutaconate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA. got7fsn_ti acetyl-CoA:(E)-glutaconate CoA-transferase activity EC:2.8.3.12|RHEA:23208|UM-BBD_reactionID:r0085|MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN molecular_function owl:Class
GO:0018010 biolink:NamedThing glycoprotein N-palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein. got7fsn_ti palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity|mucus glycoprotein fatty acyltransferase MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN molecular_function owl:Class
GO:0048542 biolink:NamedThing lymph gland development The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. got7fsn_ti haematopoietic organ development|hemopoietic organ development|hematopoietic organ development|haemopoietic organ development biological_process owl:Class
GO:1990672 biolink:NamedThing medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport. got7fsn_ti bhm 2015-03-02T11:34:39Z biological_process owl:Class
GO:0007134 biolink:NamedThing meiotic telophase I The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0004637 biolink:NamedThing phosphoribosylamine-glycine ligase activity Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate. got7fsn_ti phosphoribosylglycineamide synthetase activity|glycineamide ribonucleotide synthetase activity|5'-phosphoribosylglycinamide synthetase activity|GARS activity|GAR synthetase activity|phosphoribosylglycinamide synthetase activity|GAR|2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity|glycinamide ribonucleotide synthetase activity|5-phospho-D-ribosylamine:glycine ligase (ADP-forming) MetaCyc:GLYRIBONUCSYN-RXN|EC:6.3.4.13|RHEA:17453|Reactome:R-HSA-73814|KEGG_REACTION:R04144 molecular_function owl:Class
GO:0140403 biolink:NamedThing effector-mediated suppression of host innate immune response A process mediated by a molecule secreted by a symbiont that results in the suppression of a host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti effector-triggered suppression of host immune innate response by symbiont|effector-mediated suppression of host innate immune response by symbiont|effector triggered suppression of host immune innate response by symbiont|effector-mediated suppression of host immune innate response by symbiont|effector-dependent suppression of host immune innate response by symbiont|effector-mediated suppression of host innate immunity|effector dependent suppression of host immune innate response by symbiont pg 2019-12-05T11:34:55Z biological_process owl:Class
GO:0043648 biolink:NamedThing dicarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). got7fsn_ti dicarboxylic acid metabolism|dicarboxylate metabolism|dicarboxylate metabolic process biological_process owl:Class
GO:0106167 biolink:NamedThing extracellular ATP signaling A series of molecular signals mediated by the detection of extracellular ATP. got7fsn_ti hjd 2019-02-06T19:21:44Z biological_process owl:Class
GO:0071318 biolink:NamedThing cellular response to ATP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus. got7fsn_ti cellular response to adenosine triphosphate|cellular response to adenosine 5'-triphosphate mah 2009-12-10T05:09:47Z biological_process owl:Class
GO:0042579 biolink:NamedThing microbody Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). got7fsn_ti Wikipedia:Microbody cellular_component owl:Class
GO:0008408 biolink:NamedThing 3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. got7fsn_ti 3'-5'-exonuclease activity Reactome:R-HSA-3245943 molecular_function owl:Class
GO:0061253 biolink:NamedThing mesonephric glomerular parietal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular parietal epithelial cell. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. got7fsn_ti dph 2010-08-30T01:26:47Z biological_process owl:Class
GO:0072139 biolink:NamedThing glomerular parietal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glomerular parietal epithelial cell. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. got7fsn_ti mah 2010-02-24T01:33:05Z biological_process owl:Class
GO:0072232 biolink:NamedThing metanephric proximal convoluted tubule segment 2 development The process whose specific outcome is the progression of the S2 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the metanephric proximal tubule is involved in reabsorption of water and sodium chloride. got7fsn_ti metanephric S2 development mah 2010-03-18T03:39:28Z biological_process owl:Class
GO:0072032 biolink:NamedThing proximal convoluted tubule segment 2 development The process whose specific outcome is the progression of the S2 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S2 portion of the tubule is involved in reabsorption of water and sodium chloride. got7fsn_ti S2 development mah 2010-01-25T02:56:36Z biological_process owl:Class
GO:0004621 biolink:NamedThing glycosylphosphatidylinositol phospholipase D activity Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol. got7fsn_ti phosphatidylinositol phospholipase D activity|glycoprotein-phosphatidylinositol phosphatidohydrolase activity|phosphatidylinositol-specific phospholipase D activity|GPI-PLD activity|phosphatidylinositol-glycan-specific phospholipase D activity|glycoprotein phospholipase D activity RHEA:10832|MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN|EC:3.1.4.50|Reactome:R-HSA-8940388 molecular_function owl:Class
GO:0004630 biolink:NamedThing phospholipase D activity Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. got7fsn_ti choline phosphatase activity|lipophosphodiesterase II activity|phosphatidylcholine phosphatidohydrolase activity|lecithinase D activity EC:3.1.4.4|MetaCyc:PHOSCHOL-RXN|RHEA:14445|Reactome:R-HSA-1483182|Reactome:R-HSA-1483142|Reactome:R-HSA-2029471 molecular_function owl:Class
GO:0110071 biolink:NamedThing cellularization cleavage furrow invagination front The base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14543 kmv 2017-11-22T20:13:21Z cellular_component owl:Class
GO:0000338 biolink:NamedThing protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein. got7fsn_ti cullin deneddylation GO:0010388 biological_process owl:Class
GO:0018269 biolink:NamedThing GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine|GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine RESID:AA0162 biological_process owl:Class
GO:0050871 biolink:NamedThing positive regulation of B cell activation Any process that activates or increases the frequency, rate or extent of B cell activation. got7fsn_ti up regulation of B cell activation|positive regulation of B-cell activation|activation of B cell activation|stimulation of B cell activation|positive regulation of B-lymphocyte activation|positive regulation of B lymphocyte activation|upregulation of B cell activation|up-regulation of B cell activation biological_process owl:Class
GO:0102883 biolink:NamedThing (+)-beta-chamigrene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8424|EC:4.2.3.78|RHEA:30379 molecular_function owl:Class
GO:0043626 biolink:NamedThing PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. got7fsn_ti sliding clamp|PCNA homotrimer|proliferating cell nuclear antigen complex cellular_component owl:Class
GO:0044796 biolink:NamedThing DNA polymerase processivity factor complex A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication. got7fsn_ti jl 2013-08-28T11:16:14Z cellular_component owl:Class
GO:0061518 biolink:NamedThing microglial cell proliferation The expansion of a microglial cell population by cell division. got7fsn_ti dph 2013-04-18T13:20:21Z biological_process owl:Class
GO:0047170 biolink:NamedThing glucarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: D-glucarate + sinapoyl-CoA = 2-O-sinapoyl-D-glucarate + CoA. got7fsn_ti sinapoyl-CoA:glucarate O-(hydroxycinnamoyl)transferase activity KEGG_REACTION:R02899|RHEA:23308|MetaCyc:2.3.1.131-RXN|EC:2.3.1.131 molecular_function owl:Class
GO:0050737 biolink:NamedThing O-hydroxycinnamoyltransferase activity Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0008459 biolink:NamedThing chondroitin 6-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate. got7fsn_ti 3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity|terminal 6-sulfotransferase activity|chondroitin 6-O-sulfotransferase activity|chondroitin 6-sulphotransferase activity|3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity RHEA:11108|Reactome:R-HSA-2018682|EC:2.8.2.17|MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN|Reactome:R-HSA-3595175 molecular_function owl:Class
GO:0034481 biolink:NamedThing chondroitin sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate. got7fsn_ti molecular_function owl:Class
GO:0071103 biolink:NamedThing DNA conformation change A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule. got7fsn_ti DNA conformation modification mah 2009-11-09T11:36:34Z biological_process owl:Class
GO:0044639 biolink:NamedThing envenomation resulting in modulation of complement activation, lectin pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism. got7fsn_ti envenomation resulting in regulation of complement activation, lectin pathway in other organism jl 2012-07-05T04:53:36Z biological_process owl:Class
GO:0044646 biolink:NamedThing envenomation resulting in modulation of complement activation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism. got7fsn_ti envenomation resulting in regulation of complement activation in other organism jl 2012-07-11T12:49:28Z biological_process owl:Class
GO:0018156 biolink:NamedThing peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine). got7fsn_ti RESID:AA0112 biological_process owl:Class
GO:0001111 biolink:NamedThing promoter clearance from RNA polymerase II promoter Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. got7fsn_ti promoter escape from RNA polymerase II promoter krc 2010-12-01T03:09:31Z biological_process owl:Class
GO:0001109 biolink:NamedThing promoter clearance during DNA-templated transcription Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors. got7fsn_ti promoter escape|promoter clearance during DNA-dependent transcription krc 2010-12-01T02:13:09Z biological_process owl:Class
GO:0001666 biolink:NamedThing response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. got7fsn_ti response to sustained hypoxia|response to lowered oxygen tension|response to intermittent hypoxia|response to hypoxic stress Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. biological_process owl:Class
GO:0021991 biolink:NamedThing neural plate thickening The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode. got7fsn_ti biological_process owl:Class
GO:0022850 biolink:NamedThing serotonin-gated cation-selective channel activity Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. got7fsn_ti serotonin-gated cation channel activity|5-hydroxytryptamine-gated receptor-channel|serotonin-activated cation-selective channel activity Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'. GO:0005232 Reactome:R-HSA-975311|Reactome:R-HSA-9648983 molecular_function owl:Class
GO:0048802 biolink:NamedThing notum morphogenesis The process in which the anatomical structures of the dorsal part of the body are generated and organized. got7fsn_ti biological_process owl:Class
GO:0070138 biolink:NamedThing ubiquitin-like protein-specific isopeptidase activity Catalysis of the hydrolysis of an isopeptide bond between a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO) and a protein to which the small protein has been conjugated. got7fsn_ti small conjugating protein-specific isopeptidase activity molecular_function owl:Class
GO:0002639 biolink:NamedThing positive regulation of immunoglobulin production Any process that activates or increases the frequency, rate, or extent of immunoglobulin production. got7fsn_ti activation of immunoglobulin production|positive regulation of immunoglobulin biosynthetic process|positive regulation of immunoglobulin secretion|up regulation of immunoglobulin production|up-regulation of immunoglobulin production|stimulation of immunoglobulin production|upregulation of immunoglobulin production GO:0002642|GO:0051024 biological_process owl:Class
GO:0019726 biolink:NamedThing mevaldate reductase (NADPH) activity Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH. got7fsn_ti mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase|(R)-mevalonate:NADP+ oxidoreductase MetaCyc:MEVALDATE-REDUCTASE-NADPH-RXN|RHEA:20193|KEGG_REACTION:R02247|EC:1.1.1.33 molecular_function owl:Class
GO:0006968 biolink:NamedThing cellular defense response A defense response that is mediated by cells. got7fsn_ti intracellular defence response|intracellular defense response|cellular defence response https://github.com/geneontology/go-ontology/issues/18111 GO:0002818|GO:0016067|GO:0016066 biological_process owl:Class
GO:0000431 biolink:NamedThing regulation of transcription from RNA polymerase II promoter by galactose Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti biological_process owl:Class
GO:0036198 biolink:NamedThing dTMP salvage Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis. got7fsn_ti deoxythymidine monophosphate biosynthesis via salvage pathway|dTMP biosynthesis via salvage pathway bf 2012-04-20T10:33:28Z UniPathway:UPA00578 biological_process owl:Class
GO:0070266 biolink:NamedThing necroptotic process A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. got7fsn_ti TNF-induced necroptosis|activation of necroptosis by extracellular signals|induction of necroptosis by extracellular signals|PARP-dependent cell death|extracellular signal-induced necroptosis|necroptosis|establishment of necroptosis of activated-T cells|activation of necroptosis of activated-T cells|induction of necroptosis of activated-T cells|programmed necrotic cell death|activation of necroptosis in response to extracellular signals|parthanatos|induction of necroptosis|programmed necrosis|establishment of necroptosis|activation of necroptosis|RIPK1-mediated regulated necrosis Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097. GO:0060554|GO:0060553|GO:0060555 biological_process owl:Class
GO:0097300 biolink:NamedThing programmed necrotic cell death A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. got7fsn_ti programmed cell death by necrosis|regulated necrosis This term may be used when annotating instances of programmed cell death characterized by necrotic morphology where the involvement of RIPK1 and/or RIPK3 is not shown. See PMID:23818611 for some examples. pr 2012-05-04T03:03:39Z biological_process owl:Class
GO:0070031 biolink:NamedThing alphav-beta5 integrin-osteopontin complex A protein complex that consists of an alphav-beta5 integrin complex bound to osteopontin. got7fsn_ti ITGAV-ITGB5-SPP1 complex cellular_component owl:Class
GO:0001095 biolink:NamedThing TFIIE-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. got7fsn_ti TFIIE-class transcription factor binding krc 2010-10-28T02:49:20Z molecular_function owl:Class
GO:0005942 biolink:NamedThing phosphatidylinositol 3-kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. got7fsn_ti PIK3CA-PIK3R1 complex|PI3K complex|phosphoinositide 3-kinase complex|1-phosphatidylinositol 3-kinase complex|PIK3C3-PIK3R4 complex|PI3-kinase p85-subunit alpha- PI3-kinase p110 complex For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/ cellular_component owl:Class
GO:0099077 biolink:NamedThing histone-dependent DNA binding DNA-binding activity that is dependent on binding to a histone. got7fsn_ti molecular_function owl:Class
GO:0019981 biolink:NamedThing interleukin-6 binding Binding to interleukin-6. got7fsn_ti IL-6 binding molecular_function owl:Class
GO:0009629 biolink:NamedThing response to gravity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. got7fsn_ti response to gravitational stimulus biological_process owl:Class
GO:0098572 biolink:NamedThing stromal side of plastid thylakoid membrane The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface. got7fsn_ti cellular_component owl:Class
GO:0050842 biolink:NamedThing copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide. got7fsn_ti RESID:AA0355 biological_process owl:Class
GO:0018427 biolink:NamedThing copper incorporation into metallo-sulfur cluster The incorporation of copper into a metallo-sulfur cluster. got7fsn_ti copper incorporation into metallo-sulphur cluster biological_process owl:Class
GO:0055070 biolink:NamedThing copper ion homeostasis Any process involved in the maintenance of an internal steady state of copper ions within an organism or cell. got7fsn_ti copper homeostasis biological_process owl:Class
GO:0061683 biolink:NamedThing branching involved in seminal vesicle morphogenesis The process in which the branching structure of the seminal vesicle is generated and organized. A branch is a division or offshoot from a main stem. got7fsn_ti seminal vesicle branching morphogenesis|gonecyst branching morphogenesis|seminal gland branching morphogenesis|seminal vesicle branching dph 2015-03-04T13:39:47Z biological_process owl:Class
GO:0035247 biolink:NamedThing peptidyl-arginine omega-N-methylation The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein. got7fsn_ti RESID:AA0068|RESID:AA0069|RESID:AA0067 biological_process owl:Class
GO:0035246 biolink:NamedThing peptidyl-arginine N-methylation The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein. got7fsn_ti biological_process owl:Class
GO:0000155 biolink:NamedThing phosphorelay sensor kinase activity Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response. got7fsn_ti two-component sensor activity|two-component system sensor activity|two-component sensor molecule EC:2.7.3.- molecular_function owl:Class
GO:0034835 biolink:NamedThing 2-mercaptobenzothiazole monooxygenase activity Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole. got7fsn_ti UM-BBD_reactionID:r1178|EC:1.13.12.- molecular_function owl:Class
GO:0032896 biolink:NamedThing palmitoyl-CoA 9-desaturase activity Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O. got7fsn_ti palmitoyl-CoA delta9-desaturase acitivity molecular_function owl:Class
GO:0034797 biolink:NamedThing fosfomycin 2-glutathione ligase activity Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid. got7fsn_ti UM-BBD_reactionID:r1073 molecular_function owl:Class
GO:0016877 biolink:NamedThing ligase activity, forming carbon-sulfur bonds Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti ligase activity, forming carbon-sulphur bonds EC:6.2.-.- molecular_function owl:Class
GO:0048170 biolink:NamedThing positive regulation of long-term neuronal synaptic plasticity A process that increases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. got7fsn_ti up-regulation of long-term neuronal synaptic plasticity|stimulation of long-term neuronal synaptic plasticity|up regulation of long-term neuronal synaptic plasticity|activation of long-term neuronal synaptic plasticity|upregulation of long-term neuronal synaptic plasticity Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:0050769 biolink:NamedThing positive regulation of neurogenesis Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system. got7fsn_ti up regulation of neurogenesis|up-regulation of neurogenesis|activation of neurogenesis|upregulation of neurogenesis|stimulation of neurogenesis biological_process owl:Class
GO:0008887 biolink:NamedThing glycerate kinase activity Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+). got7fsn_ti D-glycerate kinase activity|ATP:(R)-glycerate 3-phosphotransferase activity|D-glycerate 3-kinase activity|glycerate-3-kinase activity|glycerate kinase (phosphorylating)|GK|ATP:D-glycerate 2-phosphotransferase activity|D-glyceric acid kinase activity RHEA:23516|KEGG_REACTION:R01514|MetaCyc:GLY3KIN-RXN|EC:2.7.1.31|Reactome:R-HSA-6799495 molecular_function owl:Class
GO:0061514 biolink:NamedThing interleukin-34-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-34 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti dph 2013-04-18T13:00:33Z biological_process owl:Class
GO:0062160 biolink:NamedThing spongiome A cellular anatomical entity which is a network of tubules and vessicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory. got7fsn_ti dph 2019-09-26T14:30:41Z cellular_component owl:Class
GO:0003319 biolink:NamedThing cardioblast migration to the midline involved in heart rudiment formation The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment. got7fsn_ti dph 2009-10-27T09:21:36Z biological_process owl:Class
GO:0033745 biolink:NamedThing L-methionine-(R)-S-oxide reductase activity Catalysis of the reaction: L-methionine + thioredoxin disulfide + H2O = L-methionine (R)-S-oxide + thioredoxin. got7fsn_ti free met-R-(o) reductase activity|free-methionine (R)-S-oxide reductase activity|FRMsr|L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (R)-S-oxide-forming] activity EC:1.8.4.14|RHEA:21260|MetaCyc:1.8.4.14-RXN molecular_function owl:Class
GO:0034326 biolink:NamedThing butanoyltransferase activity Catalysis of the transfer of a butanoyl (CH3-[CH2]2-CO-) group to an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0051787 biolink:NamedThing misfolded protein binding Binding to a misfolded protein. got7fsn_ti Reactome:R-HSA-5324632 molecular_function owl:Class
GO:0044841 biolink:NamedThing gut granule membrane The membrane of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. got7fsn_ti jl 2014-03-25T12:02:05Z cellular_component owl:Class
GO:0014898 biolink:NamedThing cardiac muscle hypertrophy in response to stress The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. got7fsn_ti biological_process owl:Class
GO:0008915 biolink:NamedThing lipid-A-disaccharide synthase activity Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP. got7fsn_ti UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity RHEA:22668|EC:2.4.1.182|MetaCyc:LIPIDADISACCHARIDESYNTH-RXN|KEGG_REACTION:R04606 molecular_function owl:Class
GO:0070195 biolink:NamedThing growth hormone receptor complex A receptor complex that consists of two identical subunits and binds growth hormone. got7fsn_ti cellular_component owl:Class
GO:0034844 biolink:NamedThing naphthyl-2-methyl-succinate CoA-transferase activity Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate. got7fsn_ti UM-BBD_reactionID:r1256 molecular_function owl:Class
GO:0006740 biolink:NamedThing NADPH regeneration A metabolic process that generates a pool of NADPH by the reduction of NADP+. got7fsn_ti reduced NADP regeneration|reduced nicotinamide adenine dinucleotide phosphate regeneration|NADP (reduced) regeneration biological_process owl:Class
GO:0006739 biolink:NamedThing NADP metabolic process The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH. got7fsn_ti reduced nicotinamide adenine dinucleotide phosphate metabolic process|NADPH metabolic process|nicotinamide adenine dinucleotide phosphate metabolism|NADP metabolism|NADP (oxidized) metabolic process|oxidized NADP metabolic process|reduced NADP metabolic process|nicotinamide adenine dinucleotide phosphate metabolic process|NADP (oxidized) metabolism|reduced NADP metabolism|oxidized nicotinamide adenine dinucleotide phosphate metabolic process|NADPH metabolism|oxidized nicotinamide adenine dinucleotide phosphate metabolism|reduced nicotinamide adenine dinucleotide phosphate metabolism|NAD phosphorylation and dephosphorylation|NADP (reduced) metabolism|oxidized NADP metabolism|NADP (reduced) metabolic process biological_process owl:Class
GO:0097485 biolink:NamedThing neuron projection guidance The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti neuron process guidance|neuron protrusion guidance|neurite guidance|neuronal cell projection guidance pr 2013-07-08T13:32:37Z biological_process owl:Class
GO:0070625 biolink:NamedThing zymogen granule exocytosis The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions. got7fsn_ti mah 2009-05-01T03:56:02Z biological_process owl:Class
GO:0120127 biolink:NamedThing response to zinc ion starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of zinc ion. got7fsn_ti krc 2018-02-12T19:57:02Z biological_process owl:Class
GO:0004649 biolink:NamedThing poly(ADP-ribose) glycohydrolase activity Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. got7fsn_ti Reactome:R-HSA-5651828|RHEA:52216|MetaCyc:3.2.1.143-RXN|EC:3.2.1.143|Reactome:R-HSA-8952903 molecular_function owl:Class
GO:0018702 biolink:NamedThing 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU. got7fsn_ti DDE dehalogenase activity|1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity UM-BBD_reactionID:r0440|EC:1.97.1.- molecular_function owl:Class
GO:0071628 biolink:NamedThing intrinsic component of fungal-type vacuolar membrane The component of a fungal-type vacuole membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti mah 2010-02-10T03:53:00Z cellular_component owl:Class
GO:0031310 biolink:NamedThing intrinsic component of vacuolar membrane The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to vacuolar membrane cellular_component owl:Class
GO:0022622 biolink:NamedThing root system development The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0072299 biolink:NamedThing negative regulation of metanephric glomerulus development Any process that decreases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. got7fsn_ti mah 2010-04-09T05:03:41Z biological_process owl:Class
GO:0072217 biolink:NamedThing negative regulation of metanephros development Any process that decreases the rate, frequency or extent of metanephros development. Metanephros development is the process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. The metanephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti mah 2010-03-18T01:45:48Z biological_process owl:Class
GO:0052386 biolink:NamedThing cell wall thickening A type of cell wall modification in which the cell wall is reinforced and made thicker. got7fsn_ti biological_process owl:Class
GO:1990592 biolink:NamedThing protein K69-linked ufmylation A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein. got7fsn_ti jl 2014-12-15T17:01:23Z biological_process owl:Class
GO:1990564 biolink:NamedThing protein polyufmylation Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain. got7fsn_ti jl 2014-11-26T14:15:36Z biological_process owl:Class
GO:0050175 biolink:NamedThing phenylalanine dehydrogenase activity Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH. got7fsn_ti L-phenylalanine dehydrogenase activity|PheDH activity|L-phenylalanine:NAD+ oxidoreductase (deaminating)|PHD EC:1.4.1.20|RHEA:21408|MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0008176 biolink:NamedThing tRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. got7fsn_ti transfer ribonucleate guanine 7-methyltransferase activity|tRNA guanine 7-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity|7-methylguanine transfer ribonucleate methylase activity|N7-methylguanine methylase activity|S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity Reactome:R-HSA-6782286|RHEA:42708|MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN|EC:2.1.1.33 molecular_function owl:Class
GO:0010030 biolink:NamedThing positive regulation of seed germination Any process that activates or increase the rate of seed germination. got7fsn_ti up regulation of seed germination|activation of seed germination|up-regulation of seed germination|upregulation of seed germination|stimulation of seed germination biological_process owl:Class
GO:0048582 biolink:NamedThing positive regulation of post-embryonic development Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. got7fsn_ti up regulation of post-embryonic development|activation of post-embryonic development|upregulation of post-embryonic development|stimulation of post-embryonic development|up-regulation of post-embryonic development biological_process owl:Class
GO:0101006 biolink:NamedThing protein histidine phosphatase activity Catalysis of the reaction: protein histidine phosphate + H2O = protein histidine + phosphate. got7fsn_ti phosphohistidine phosphatase activity https://github.com/geneontology/go-ontology/issues/21517 This eukaryotic enzyme dephosphorylates phosphorylated histidine residues within proteins and peptides. The enzyme acts on phosphate groups attached to both the pros- (RHEA:47964) and tele- (RHEA:47960) nitrogen atoms, but the pros- position is somewhat preferred (by a factor of two at the most) (EC:3.9.1.3). GO:0008969 RHEA:47964|EC:3.9.1.3 molecular_function owl:Class
GO:0009110 biolink:NamedThing vitamin biosynthetic process The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti vitamin formation|vitamin biosynthesis|vitamin synthesis|vitamin anabolism biological_process owl:Class
GO:0006766 biolink:NamedThing vitamin metabolic process The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems. got7fsn_ti vitamin metabolism biological_process owl:Class
GO:0098733 biolink:NamedThing hemidesmosome associated protein complex Any protein complex that is part of or has some part in a hemidesmosome. got7fsn_ti cellular_component owl:Class
GO:0019417 biolink:NamedThing sulfur oxidation The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur. got7fsn_ti sulphur oxidation biological_process owl:Class
GO:0008239 biolink:NamedThing dipeptidyl-peptidase activity Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 MetaCyc:3.4.14.4-RXN|EC:3.4.14.2|EC:3.4.14.4|EC:3.4.14.11|EC:3.4.14.5|MetaCyc:3.4.14.11-RXN|EC:3.4.14.1 molecular_function owl:Class
GO:0046885 biolink:NamedThing regulation of hormone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. got7fsn_ti regulation of hormone synthesis|regulation of hormone biosynthesis|regulation of hormone anabolism|regulation of hormone formation biological_process owl:Class
GO:0003248 biolink:NamedThing heart capillary growth The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle. got7fsn_ti dph 2009-10-13T11:53:12Z biological_process owl:Class
GO:0097741 biolink:NamedThing mastigoneme A hair-like structure covering the flagella found in some algae (heterokonts and cryptophytes). It is approximately 15 nm in diameter, and usually consist of a tubular shaft that itself terminates in smaller hairs. It is composed of glycoproteins and, likely, carbohydrates. Mastigonemes may assist in locomotion by increasing the surface area of a flagellum. got7fsn_ti pr 2016-10-19T11:33:38Z cellular_component owl:Class
GO:0051308 biolink:NamedThing male meiosis chromosome separation The process in which paired chromosomes are physically detached from each other during male meiosis. got7fsn_ti male meiosis chromosome resolution|chromosome separation during male meiosis biological_process owl:Class
GO:0007060 biolink:NamedThing male meiosis chromosome segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male. got7fsn_ti biological_process owl:Class
GO:0032132 biolink:NamedThing O6-alkylguanine-DNA binding Binding to an O6-alkylguanine adduct in DNA. got7fsn_ti molecular_function owl:Class
GO:0032131 biolink:NamedThing alkylated DNA binding Binding to an alkylated residue in DNA. got7fsn_ti molecular_function owl:Class
GO:0035202 biolink:NamedThing tracheal pit formation in open tracheal system Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster. got7fsn_ti tracheal sac formation|tracheal placode invagination biological_process owl:Class
GO:2001153 biolink:NamedThing positive regulation of renal water transport Any process that activates or increases the frequency, rate or extent of renal water transport. got7fsn_ti yaf 2011-10-24T11:38:01Z biological_process owl:Class
GO:0030234 biolink:NamedThing enzyme regulator activity Binds to and modulates the activity of an enzyme. got7fsn_ti enzyme modulator|metalloenzyme regulator activity|catalytic regulator activity This term should only be used in cases when the regulator directly interacts with the enzyme. GO:0010576 molecular_function owl:Class
GO:0043334 biolink:NamedThing 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. got7fsn_ti 2-hexaprenyl-6-methoxy-1,4-benzoquinone methylase activity Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. molecular_function owl:Class
GO:0050887 biolink:NamedThing determination of sensory modality The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain. got7fsn_ti biological_process owl:Class
GO:0050893 biolink:NamedThing sensory processing Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect. got7fsn_ti biological_process owl:Class
GO:0102389 biolink:NamedThing polyprenol reductase activity Catalysis of the reaction: NADP + a ditrans,polycis-dolichol = NADPH + H+ + a di-trans, poly-cis-polyprenol. got7fsn_ti MetaCyc:RXN-13604|RHEA:34279|EC:1.3.1.94 molecular_function owl:Class
GO:0048868 biolink:NamedThing pollen tube development The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure. got7fsn_ti biological_process owl:Class
GO:0047816 biolink:NamedThing D-arabinose 1-dehydrogenase (NAD+) activity Catalysis of the reaction: D-arabinose + NAD+ = D-arabinono-1,4-lactone + NADH. got7fsn_ti D-arabinose:NAD+ 1-oxidoreductase activity|NAD-pentose-dehydrogenase activity|arabinose(fucose)dehydrogenase activity RHEA:20457|MetaCyc:D-ARABINOSE-1-DEHYDROGENASE-RXN|EC:1.1.1.116 molecular_function owl:Class
GO:0045290 biolink:NamedThing D-arabinose 1-dehydrogenase [NAD(P)+] activity Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+. got7fsn_ti D-arabinose:NAD(P)+ 1-oxidoreductase activity MetaCyc:1.1.1.117-RXN|EC:1.1.1.117 molecular_function owl:Class
GO:0120318 biolink:NamedThing olfactory sociosexual communication The use of external chemical cues called pheromones to send social and sexual information between members of the same species, leading to specific behavioral responses. Pheromones may be detected by two olfactory sensory circuits, the main olfactory pathway and the vomeronasal system. got7fsn_ti Behavior such as predation which involves members of different species is not social. Communication between members of different species is also not social behavior. krc 2021-05-21T19:35:58Z biological_process owl:Class
GO:0019391 biolink:NamedThing glucuronoside catabolic process The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue. got7fsn_ti glucuronoside catabolism|glucuronoside degradation|glucuronoside breakdown|glucuronide catabolism|glucuronide catabolic process MetaCyc:GLUCUROCAT-PWY biological_process owl:Class
GO:0103102 biolink:NamedThing UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 8-methylthiooctylhydroximate <=> H+ + 7-methylthioheptyldesulfoglucosinolate + UDP. got7fsn_ti EC:2.4.1.195|MetaCyc:RXNQT-4327 molecular_function owl:Class
GO:0002019 biolink:NamedThing regulation of renal output by angiotensin The process in which angiotensin directly modulates the rate of urine output by the kidney. got7fsn_ti angiotensin-mediated regulation of renal output|angiotensin mediated control of renal output|angiotensin mediated regulation of renal output biological_process owl:Class
GO:0002016 biolink:NamedThing regulation of blood volume by renin-angiotensin The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood. got7fsn_ti renin-angiotensin regulation of blood volume|renin-angiotensin control of body fluid levels biological_process owl:Class
GO:0019176 biolink:NamedThing dihydroneopterin monophosphate phosphatase activity Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate. got7fsn_ti dihydroneopterin monophosphate dephosphorylase activity MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN|RHEA:25306 molecular_function owl:Class
GO:0001113 biolink:NamedThing transcription open complex formation at RNA polymerase II promoter Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble. got7fsn_ti RNA polymerase II promoter melting|transcriptional open complex formation at RNA polymerase II promoter krc 2010-12-02T02:27:19Z biological_process owl:Class
GO:0000182 biolink:NamedThing rDNA binding Binding to a DNA sequence encoding a ribosomal RNA. got7fsn_ti ribosomal DNA binding molecular_function owl:Class
GO:1990070 biolink:NamedThing TRAPPI protein complex A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the core subunits of all TRAPP complexes in yeast. got7fsn_ti TRAPP core complex bhm 2013-03-28T14:04:40Z cellular_component owl:Class
GO:0002461 biolink:NamedThing tolerance induction dependent upon immune response Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation. got7fsn_ti immune response-dependent tolerance induction biological_process owl:Class
GO:0005902 biolink:NamedThing microvillus Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. got7fsn_ti microvilli Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. Wikipedia:Microvillus|NIF_Subcellular:sao671419673 cellular_component owl:Class
GO:0018418 biolink:NamedThing nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. got7fsn_ti nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide RESID:AA0 biological_process owl:Class
GO:0018414 biolink:NamedThing nickel incorporation into metallo-sulfur cluster The incorporation of nickel into a metallo-sulfur cluster. got7fsn_ti nickel incorporation into metallo-sulphur cluster biological_process owl:Class
GO:0035013 biolink:NamedThing myosuppressin receptor activity Combining with the peptide myosuppressin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0039674 biolink:NamedThing exit of virus from host cell nucleus The directed movement of the viral genome or a viral particle out of the host cell nucleus. got7fsn_ti bf 2013-09-25T13:59:41Z VZ:2177 biological_process owl:Class
GO:0102137 biolink:NamedThing 7-oxateasterone synthase activity Catalysis of the reaction: H+ + teasterone + NADPH + O2 <=> 7-oxateasterone + NADP + H2O. got7fsn_ti MetaCyc:RXN-11537 molecular_function owl:Class
GO:0090668 biolink:NamedThing endothelial cell chemotaxis to vascular endothelial growth factor The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF). got7fsn_ti tb 2015-12-15T11:31:43Z biological_process owl:Class
GO:0090667 biolink:NamedThing cell chemotaxis to vascular endothelial growth factor The directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF). got7fsn_ti tb 2015-12-15T11:27:12Z biological_process owl:Class
GO:0047319 biolink:NamedThing aspartate-phenylpyruvate transaminase activity Catalysis of the reaction: keto-phenylpyruvate + L-aspartate = L-phenylalanine + oxaloacetate. got7fsn_ti L-aspartate:phenylpyruvate aminotransferase activity|aspartate--phenylpyruvate aminotransferase activity|aspartate-phenylpyruvate aminotransferase activity RHEA:14097|EC:2.6.1.70|KEGG_REACTION:R00695|MetaCyc:2.6.1.70-RXN molecular_function owl:Class
GO:0018727 biolink:NamedThing 2-phenanthrol sulfotransferase activity Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate. got7fsn_ti 2-phenanthrol sulphotransferase activity UM-BBD_reactionID:r0563 molecular_function owl:Class
GO:0075217 biolink:NamedThing negative regulation of spore encystment on host Any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0075215 biolink:NamedThing modulation of spore encystment on host Any process that modulates the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0032401 biolink:NamedThing establishment of melanosome localization The directed movement of a melanosome to a specific location. got7fsn_ti establishment of melanosome localisation biological_process owl:Class
GO:0033545 biolink:NamedThing myo-inositol hexakisphosphate biosynthetic process, lipid-dependent The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C. got7fsn_ti myo-inositol hexakisphosphate synthesis, lipid-dependent|myo-inositol hexakisphosphate biosynthesis, lipid-dependent|phytate biosynthetic process, lipid-dependent|myo-inositol hexakisphosphate anabolism, lipid-dependent|phytate biosynthesis, lipid-dependent|myo-inositol hexakisphosphate formation, lipid-dependent MetaCyc:PWY-6555 biological_process owl:Class
GO:0010264 biolink:NamedThing myo-inositol hexakisphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds. got7fsn_ti myo-inositol hexakisphosphate formation|phytate biosynthetic process|myo-inositol hexakisphosphate synthesis|myo-inositol hexakisphosphate biosynthesis|phytate biosynthesis|myo-inositol hexakisphosphate anabolism biological_process owl:Class
GO:0033447 biolink:NamedThing AGA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AGA codon. got7fsn_ti arginine tRNA Note that in the standard genetic code, AGA codes for arginine. molecular_function owl:Class
GO:0008424 biolink:NamedThing glycoprotein 6-alpha-L-fucosyltransferase activity Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+). got7fsn_ti guanosine diphosphofucose--glycoprotein fucosyltransferase activity|glycoprotein fucosyltransferase activity|GDPfucose-glycoprotein fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity|FucT|GDP-fucose--glycoprotein fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity|GDP-L-fucose--glycoprotein fucosyltransferase activity EC:2.4.1.68|Reactome:R-HSA-1028788|KEGG_REACTION:R05988|Reactome:R-HSA-9696980|RHEA:12985|MetaCyc:2.4.1.68-RXN molecular_function owl:Class
GO:0052866 biolink:NamedThing phosphatidylinositol phosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. got7fsn_ti phosphoinositide phosphatase activity ai 2011-12-13T01:20:17Z molecular_function owl:Class
GO:0042924 biolink:NamedThing neuromedin U binding Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses. got7fsn_ti NMU binding molecular_function owl:Class
GO:0042923 biolink:NamedThing neuropeptide binding Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). got7fsn_ti molecular_function owl:Class
GO:0061559 biolink:NamedThing cranial ganglion morphogenesis The process in which the anatomical structure of a cranial ganglion is generated and organized. got7fsn_ti cranial ganglia morphogenesis dph 2013-07-10T09:02:15Z biological_process owl:Class
GO:0061552 biolink:NamedThing ganglion morphogenesis The process in which the anatomical structures of ganglion are generated and organized. got7fsn_ti ganglia morphogenesis dph 2013-07-10T08:44:57Z biological_process owl:Class
GO:0046886 biolink:NamedThing positive regulation of hormone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. got7fsn_ti stimulation of hormone biosynthetic process|positive regulation of hormone biosynthesis|positive regulation of hormone formation|upregulation of hormone biosynthetic process|up regulation of hormone biosynthetic process|up-regulation of hormone biosynthetic process|activation of hormone biosynthetic process|positive regulation of hormone anabolism|positive regulation of hormone synthesis biological_process owl:Class
GO:0032352 biolink:NamedThing positive regulation of hormone metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone. got7fsn_ti up-regulation of hormone metabolic process|stimulation of hormone metabolic process|positive regulation of hormone metabolism|upregulation of hormone metabolic process|up regulation of hormone metabolic process|activation of hormone metabolic process biological_process owl:Class
GO:0071421 biolink:NamedThing manganese ion transmembrane transport A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti manganese ion membrane transport|transmembrane manganese transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2009-12-15T02:41:31Z biological_process owl:Class
GO:0006828 biolink:NamedThing manganese ion transport The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0002049 biolink:NamedThing pyoverdine biosynthetic process The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine. got7fsn_ti biological_process owl:Class
GO:0008540 biolink:NamedThing proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex. got7fsn_ti cellular_component owl:Class
GO:0070326 biolink:NamedThing very-low-density lipoprotein particle receptor binding Binding to a very-low-density lipoprotein receptor. got7fsn_ti VLDL receptor binding|VLDLR binding|apolipoprotein E receptor binding|very-low-density lipoprotein receptor binding molecular_function owl:Class
GO:0070325 biolink:NamedThing lipoprotein particle receptor binding Binding to a lipoprotein particle receptor. got7fsn_ti molecular_function owl:Class
GO:0044053 biolink:NamedThing translocation of peptides or proteins into host cell cytoplasm The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm. got7fsn_ti transport of peptides or proteins into host cell cytoplasm|translocation of symbiont peptides or proteins into host cell cytoplasm biological_process owl:Class
GO:0044355 biolink:NamedThing clearance of foreign intracellular DNA A defense process that protects an organism from invading foreign DNA. got7fsn_ti clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine https://github.com/geneontology/go-ontology/issues/18727 jl 2011-08-11T11:25:43Z GO:0044356 biological_process owl:Class
GO:0046283 biolink:NamedThing anthocyanin-containing compound metabolic process The chemical reactions and pathways involving anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins that occur in plants. They are responsible from most of the scarlet, purple, mauve and blue coloring in higher plants, especially of flowers. got7fsn_ti anthocyanin metabolism|anthocyanin metabolic process biological_process owl:Class
GO:0009812 biolink:NamedThing flavonoid metabolic process The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins. got7fsn_ti flavonoid metabolism biological_process owl:Class
GO:0071260 biolink:NamedThing cellular response to mechanical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. got7fsn_ti cellular mechanical stimulus response mah 2009-12-04T03:55:44Z biological_process owl:Class
GO:0044278 biolink:NamedThing cell wall disruption in other organism A process carried out by an organism that results in the breakdown of the cell wall of a second organism. got7fsn_ti jl 2010-01-14T02:01:48Z biological_process owl:Class
GO:2000273 biolink:NamedThing positive regulation of signaling receptor activity Any process that activates or increases the frequency, rate or extent of signaling receptor activity. got7fsn_ti positive regulation of signalling receptor activity bf 2010-12-02T09:28:50Z biological_process owl:Class
GO:0140289 biolink:NamedThing protein mono-ADP-ribosylation The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids. got7fsn_ti pg 2018-11-22T13:52:54Z biological_process owl:Class
GO:0000901 biolink:NamedThing translation repressor activity, non-nucleic acid binding Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid. got7fsn_ti molecular_function owl:Class
GO:0070677 biolink:NamedThing rRNA (cytosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine. got7fsn_ti mah 2009-05-29T03:37:53Z molecular_function owl:Class
GO:0016434 biolink:NamedThing rRNA (cytosine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine. got7fsn_ti molecular_function owl:Class
GO:0051210 biolink:NamedThing isotropic cell growth The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth. got7fsn_ti uniform cell growth biological_process owl:Class
GO:0005798 biolink:NamedThing Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. got7fsn_ti Golgi vesicle|vesicular component Note that this definition includes vesicles that are transiently associated with the Golgi. NIF_Subcellular:sao819927218 cellular_component owl:Class
GO:0072195 biolink:NamedThing kidney smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the kidney. got7fsn_ti mah 2010-03-01T02:07:52Z biological_process owl:Class
GO:0045551 biolink:NamedThing cinnamyl-alcohol dehydrogenase activity Catalysis of the reaction: cinnamyl alcohol + NADP+ = cinnamaldehyde + NADPH + H+. got7fsn_ti CAD activity|cinnamyl alcohol dehydrogenase activity|cinnamyl-alcohol:NADP+ oxidoreductase activity EC:1.1.1.195|RHEA:10392|MetaCyc:CINNAMYL-ALCOHOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0002230 biolink:NamedThing positive regulation of defense response to virus by host Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication. got7fsn_ti up-regulation of antiviral response by host|upregulation of antiviral response by host|up regulation of antiviral response by host|stimulation of antiviral response by host|activation of antiviral response by host|positive regulation of antiviral response by host biological_process owl:Class
GO:0050691 biolink:NamedThing regulation of defense response to virus by host Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism. got7fsn_ti regulation of antiviral response by host|host regulation of antiviral response|regulation by host of antiviral response biological_process owl:Class
GO:0021584 biolink:NamedThing pons formation The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. got7fsn_ti biological_process owl:Class
GO:0072635 biolink:NamedThing interleukin-31 production The appearance of interleukin-31 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-31 production|interleukin-31 secretion GO:0072636 biological_process owl:Class
GO:0102391 biolink:NamedThing decanoate-CoA ligase activity Catalysis of the reaction: ATP + decanoate + CoA = AMP + diphosphate + decanoyl-CoA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18967 RHEA:33627|MetaCyc:RXN-13614 molecular_function owl:Class
GO:0004500 biolink:NamedThing dopamine beta-monooxygenase activity Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O. got7fsn_ti (3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity|4-(2-aminoethyl)pyrocatechol beta-oxidase activity|SDBH (soluble dopamine beta-monooxygenase)|3,4-dihydroxyphenethylamine beta-oxidase activity|oxygenase, dopamine beta-mono-|dopamine b-hydroxylase activity|3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)|dopamine beta-oxidase activity|dopa beta-hydroxylase activity|dopamine-B-hydroxylase activity|phenylamine beta-hydroxylase activity|dopamine hydroxylase activity|MDBH (membrane-associated dopamine beta-monooxygenase)|dopamine beta-hydroxylase activity MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN|RHEA:19117|Reactome:R-HSA-209891|KEGG_REACTION:R02535|EC:1.14.17.1 molecular_function owl:Class
GO:0003684 biolink:NamedThing damaged DNA binding Binding to damaged DNA. got7fsn_ti DNA repair protein|DNA repair enzyme molecular_function owl:Class
GO:0071174 biolink:NamedThing mitotic spindle checkpoint signaling A signaling process that contributes to a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form. got7fsn_ti topoisomerase II checkpoint|mitotic spindle checkpoint|mitotic cell cycle spindle checkpoint|signal transduction involved in mitotic spindle checkpoint|topo II checkpoint|signal transduction involved in mitotic cell cycle spindle checkpoint https://github.com/geneontology/go-ontology/issues/20935 Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation checkpoints). mah 2009-11-23T12:41:36Z GO:0072477 biological_process owl:Class
GO:0080072 biolink:NamedThing spermidine:sinapoyl CoA N-acyltransferase activity Catalysis of the transfer of a sinapoyl group to a nitrogen atom on the spermidine molecule. got7fsn_ti dhl 2009-04-13T04:16:28Z molecular_function owl:Class
GO:0010404 biolink:NamedThing cell wall hydroxyproline-rich glycoprotein metabolic process The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates. got7fsn_ti cell wall hydroxyproline-rich glycoprotein metabolism biological_process owl:Class
GO:0042134 biolink:NamedThing rRNA primary transcript binding Binding to an unprocessed ribosomal RNA transcript. got7fsn_ti pre-rRNA binding molecular_function owl:Class
GO:0043133 biolink:NamedThing hindgut contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine. got7fsn_ti biological_process owl:Class
GO:0061556 biolink:NamedThing trigeminal ganglion morphogenesis The process in which the anatomical structure of a trigeminal ganglion is generated and organized. got7fsn_ti trigeminal ganglia morphogenesis dph 2013-07-10T08:57:12Z biological_process owl:Class
GO:0060402 biolink:NamedThing calcium ion transport into cytosol The directed movement of calcium ions (Ca2+) into the cytosol. got7fsn_ti biological_process owl:Class
GO:0060401 biolink:NamedThing cytosolic calcium ion transport The directed movement of calcium ions (Ca2+) into, out of or within the cytosol. got7fsn_ti biological_process owl:Class
GO:0018379 biolink:NamedThing cytochrome c-heme linkage via heme-bis-L-cysteine The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine. got7fsn_ti cytochrome c-haem linkage via haem-bis-L-cysteine RESID:AA0134 biological_process owl:Class
GO:0000117 biolink:NamedThing regulation of transcription involved in G2/M transition of mitotic cell cycle Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle. got7fsn_ti regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle|G2/M-specific transcription in mitotic cell cycle biological_process owl:Class
GO:0120219 biolink:NamedThing subapical part of cell The region of a polarized cell that is just below the apical region. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue so the subapical region is further from the exposed surface and closer to the basal lamina. got7fsn_ti subapical region of cell krc 2019-11-15T17:08:22Z cellular_component owl:Class
GO:0042754 biolink:NamedThing negative regulation of circadian rhythm Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior. got7fsn_ti down regulation of circadian rhythm|downregulation of circadian rhythm|down-regulation of circadian rhythm|inhibition of circadian rhythm biological_process owl:Class
GO:0033989 biolink:NamedThing 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity Catalysis of the reaction: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA + H2O. got7fsn_ti 46 kDa hydratase 2 activity|(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA-forming] activity|D-3-hydroxyacyl-CoA dehydratase activity|(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase activity Reactome:R-HSA-193535|EC:4.2.1.107|MetaCyc:4.2.1.107-RXN|Reactome:R-HSA-192331|RHEA:18933 molecular_function owl:Class
GO:0072081 biolink:NamedThing specification of nephron tubule identity The process in which the tubules arranged along the proximal/distal axis of the nephron acquire their identity. got7fsn_ti mah 2010-02-01T02:42:34Z biological_process owl:Class
GO:0045500 biolink:NamedThing sevenless signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti sev receptor signaling pathway|sev signaling pathway|sevenless signalling pathway biological_process owl:Class
GO:0007169 biolink:NamedThing transmembrane receptor protein tyrosine kinase signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti transmembrane receptor protein tyrosine kinase signalling pathway biological_process owl:Class
GO:0090524 biolink:NamedThing cytochrome-b5 reductase activity, acting on NADH Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5). got7fsn_ti cytochrome b5 reductase activity tb 2013-01-11T12:21:50Z molecular_function owl:Class
GO:0004128 biolink:NamedThing cytochrome-b5 reductase activity, acting on NAD(P)H Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). got7fsn_ti reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity|cytochrome b5 reductase activity|dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity|NADH 5alpha-reductase activity|NADH-cytochrome b5 reductase activity|NADH-cytochrome-b5 reductase activity|NADH:ferricytochrome-b5 oxidoreductase activity|NADH-ferricytochrome b5 oxidoreductase activity Reactome:R-HSA-6806831|Reactome:R-HSA-198824|RHEA:46680|MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN|EC:1.6.2.2 molecular_function owl:Class
GO:0090619 biolink:NamedThing meiotic spindle pole Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. got7fsn_ti tb 2014-12-16T16:38:34Z cellular_component owl:Class
GO:0000922 biolink:NamedThing spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. got7fsn_ti GO:0030615 cellular_component owl:Class
GO:0048794 biolink:NamedThing swim bladder development The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. got7fsn_ti gas bladder development biological_process owl:Class
GO:0019652 biolink:NamedThing lactate fermentation to propionate and acetate The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP). got7fsn_ti nonrandomizing pathway|propionate fermentation|acrylate pathway MetaCyc:PROPFERM-PWY biological_process owl:Class
GO:0019662 biolink:NamedThing non-glycolytic fermentation Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway. got7fsn_ti biological_process owl:Class
GO:0043333 biolink:NamedThing 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. got7fsn_ti 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity https://github.com/geneontology/go-ontology/issues/15686 Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. GO:0102005 MetaCyc:2-OCTAPRENYL-METHOXY-BENZOQ-METH-RXN|EC:2.1.1.201 molecular_function owl:Class
GO:0102499 biolink:NamedThing SHG alpha-glucan phosphorylase activity Catalysis of the reaction: hydrogenphosphate + a plant soluble heteroglycan = alpha-D-glucose 1-phosphate + a plant soluble heteroglycan. got7fsn_ti EC:2.4.1.1|MetaCyc:RXN-14353|RHEA:41732 molecular_function owl:Class
GO:0102057 biolink:NamedThing jasmonoyl-valine synthetase activity Catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-valine. got7fsn_ti MetaCyc:RXN-10457 molecular_function owl:Class
GO:0061272 biolink:NamedThing mesonephric connecting tubule development The process whose specific outcome is the progression of the mesonephric connecting tubule over time, from its formation to the mature structure. The mesonephric connecting tubule is a tubular segment of the mesonephric nephron; it connects the distal tubule to the collecting duct in the mesonephros. got7fsn_ti mesonephric connecting duct development|mesonephric collecting tubule development dph 2010-09-02T12:00:56Z biological_process owl:Class
GO:0061242 biolink:NamedThing mesonephric nephron tubule development The progression of a mesonephric nephron tubule over time, from its initial formation to the mature structure. A mesonephric nephron tubule is an epithelial tube that is part of the mesonephric nephron, the functional part of the mesonephros. got7fsn_ti dph 2010-08-19T03:17:00Z biological_process owl:Class
GO:0004386 biolink:NamedThing helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. got7fsn_ti ATP-dependent helicase activity https://github.com/geneontology/go-ontology/issues/21393 Note that most helicases catalyze processive duplex unwinding. GO:0008026 Reactome:R-HSA-169461|Reactome:R-HSA-5686410|Reactome:R-HSA-169468|Reactome:R-HSA-5690996 molecular_function owl:Class
GO:0030666 biolink:NamedThing endocytic vesicle membrane The lipid bilayer surrounding an endocytic vesicle. got7fsn_ti cellular_component owl:Class
GO:0097579 biolink:NamedThing extracellular sequestering of copper ion The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system. got7fsn_ti extracellular copper ion sequestering|extracellular sequestration of copper ion|extracellular retention of copper ion|extracellular storage of copper ion|extracellular copper ion retention|extracellular copper ion storage|extracellular copper ion sequestration pr 2014-02-28T11:18:04Z biological_process owl:Class
GO:0008123 biolink:NamedThing cholesterol 7-alpha-monooxygenase activity Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. got7fsn_ti cholesterol 7alpha-monooxygenase activity|cholesterol 7alpha-hydroxylase activity|cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)|cholesterol 7-alpha-hydroxylase activity|cytochrome P450 CYP7A1 Reactome:R-HSA-192051|MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN|RHEA:21812|EC:1.14.14.23 molecular_function owl:Class
GO:0021904 biolink:NamedThing dorsal/ventral neural tube patterning The process in which the neural tube is regionalized in the dorsoventral axis. got7fsn_ti dorsal-ventral neural tube patterning|dorsoventral neural tube patterning biological_process owl:Class
GO:1900592 biolink:NamedThing violaceol II catabolic process The chemical reactions and pathways resulting in the breakdown of violaceol II. got7fsn_ti violaceol II degradation|violaceol II breakdown|violaceol II catabolism di 2012-05-15T06:51:43Z biological_process owl:Class
GO:0038186 biolink:NamedThing lithocholic acid receptor activity Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity. got7fsn_ti LCA receptor activity bf 2013-05-16T11:13:38Z molecular_function owl:Class
GO:0038181 biolink:NamedThing bile acid receptor activity Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile. got7fsn_ti bf 2013-05-16T10:27:02Z molecular_function owl:Class
GO:0102980 biolink:NamedThing 2-butyl-4-hydroxy-5-methyl-3(2H)-furanoneoxidoreductase activity Catalysis of the reaction: 2-butyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP <=> (2E)-2-butylidene-4-hydroxy-5-methyl-3(2H)-furanone + NADPH + H+. got7fsn_ti MetaCyc:RXN-9565 molecular_function owl:Class
GO:0090441 biolink:NamedThing trehalose biosynthesis in response to heat stress The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. got7fsn_ti trehalose biosynthetic process in response to heat stress tb 2012-08-23T13:53:07Z biological_process owl:Class
GO:0009092 biolink:NamedThing homoserine metabolic process The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine. got7fsn_ti homoserine metabolism biological_process owl:Class
GO:0061318 biolink:NamedThing renal filtration cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a renal filtration cell. Renal filtration cells are specialized cells of the renal system that filter fluids by charge, size or both. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. got7fsn_ti dph 2010-09-24T12:18:35Z biological_process owl:Class
GO:0050891 biolink:NamedThing multicellular organismal water homeostasis Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism. got7fsn_ti body fluid osmoregulation biological_process owl:Class
GO:0018642 biolink:NamedThing chlorophenol 4-monooxygenase activity Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol. got7fsn_ti UM-BBD_enzymeID:e0252|EC:1.14.13.- molecular_function owl:Class
GO:0048016 biolink:NamedThing inositol phosphate-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). got7fsn_ti inositol phosphate-mediated signalling biological_process owl:Class
GO:0019932 biolink:NamedThing second-messenger-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. got7fsn_ti second messenger-mediated signalling|second-messenger-mediated signal transduction|second messenger-mediated signaling|second-messenger-mediated signalling|second messenger mediated signaling|second messenger mediated signalling biological_process owl:Class
GO:0101020 biolink:NamedThing estrogen 16-alpha-hydroxylase activity Catalysis of the reaction: estrogen + donor-H2 + O2 = 16-alpha-hydroxyestrogen + H2O. got7fsn_ti oestrogen 16-alpha-hydroxylase activity molecular_function owl:Class
GO:0030026 biolink:NamedThing cellular manganese ion homeostasis Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell. got7fsn_ti manganese homeostasis biological_process owl:Class
GO:0055071 biolink:NamedThing manganese ion homeostasis Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell. got7fsn_ti manganese homeostasis biological_process owl:Class
GO:0031809 biolink:NamedThing H3 histamine receptor binding Binding to a H3 histamine receptor. got7fsn_ti H3 histamine receptor ligand molecular_function owl:Class
GO:0050941 biolink:NamedThing negative regulation of pigment cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation. got7fsn_ti downregulation of pigment cell differentiation|inhibition of pigment cell differentiation|down-regulation of pigment cell differentiation|down regulation of pigment cell differentiation biological_process owl:Class
GO:0048086 biolink:NamedThing negative regulation of developmental pigmentation Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. got7fsn_ti downregulation of developmental pigmentation|down regulation of developmental pigmentation|inhibition of pigmentation|down-regulation of developmental pigmentation biological_process owl:Class
GO:0072289 biolink:NamedThing metanephric nephron tubule formation The developmental process pertaining to the initial formation of a metanephric nephron tubule from unspecified parts. A metanephric nephron tubule is an epithelial tube that is part of a nephron in the metanephros. got7fsn_ti mah 2010-04-09T03:47:44Z biological_process owl:Class
GO:0072079 biolink:NamedThing nephron tubule formation The developmental process pertaining to the initial formation of a nephron tubule from unspecified parts. A nephron tubule is an epithelial tube that is part of the nephron, the functional part of the kidney. got7fsn_ti mah 2010-02-01T02:29:26Z biological_process owl:Class
GO:0120122 biolink:NamedThing prolactin metabolic process The chemical reactions and pathways involving prolactin, a protein hormone of the anterior pituitary gland that promotes lactation in response to the suckling stimulus of hungry young mammals. got7fsn_ti prolactin metabolism krc 2018-01-25T17:28:40Z biological_process owl:Class
GO:2001003 biolink:NamedThing regulation of pectin catabolic process Any process that modulates the frequency, rate or extent of pectin catabolic process. got7fsn_ti regulation of pectin breakdown|regulation of pectin catabolism|regulation of pectin degradation tt 2011-08-08T03:24:01Z biological_process owl:Class
GO:0021606 biolink:NamedThing accessory nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. got7fsn_ti spinal accessory nerve maturation|CN XI maturation biological_process owl:Class
GO:0098517 biolink:NamedThing detection of low humidity The series of events in which low humidity is detected and converted into a molecular signal. got7fsn_ti dos 2013-09-25T14:27:18Z biological_process owl:Class
GO:0098513 biolink:NamedThing detection of humidity The series of events in which a humidity stimulus is received and converted into a molecular signal. got7fsn_ti dos 2013-09-25T14:11:13Z biological_process owl:Class
GO:0046730 biolink:NamedThing induction by virus of host immune response The induction by a virus of an immune response in the host organism. got7fsn_ti passive induction of humoral immune response in host by virus|passive viral activation of humoral immune response in host|passive induction of host innate immune response by virus|passive induction of cell-mediated immune response in host by virus|passive viral activation of innate immune response in host|passive viral induction of host immune response|passive induction of host cell-mediated immune response by virus|passive viral induction of cell-mediated immune response in host|active viral induction of host immune response|passive viral induction of innate immune response in host|passive viral induction of humoral immune response in host|passive viral activation of cell-mediated immune response in host|passive induction of innate immune response in host by virus|passive induction of host immune response by virus|active induction of host immune response by virus|activation of host immune response by virus|passive induction of host humoral immune response by virus|passive activation of host immune response by virus GO:0046735|GO:0046734|GO:0046733|GO:0046731|GO:0046732 biological_process owl:Class
GO:0004798 biolink:NamedThing thymidylate kinase activity Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. got7fsn_ti ATP:dTMP phosphotransferase activity|deoxythymidine 5'-monophosphate kinase activity|thymidylate monophosphate kinase activity|thymidine monophosphate kinase activity|thymidylic acid kinase activity|TMPK activity|thymidine 5'-monophosphate kinase activity|thymidylic kinase activity|dTMP kinase activity EC:2.7.4.9|MetaCyc:DTMPKI-RXN|RHEA:13517 molecular_function owl:Class
GO:0016464 biolink:NamedThing chloroplast protein-transporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma. got7fsn_ti ATPase-coupled chloroplast protein transporter activity|AAA chloroplast protein-transporting ATPase MetaCyc:3.6.3.52-RXN|EC:7.4.2.4 molecular_function owl:Class
GO:0015450 biolink:NamedThing protein-transporting ATPase activity Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. got7fsn_ti P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein translocase activity https://github.com/geneontology/go-ontology/issues/21271 Reactome:R-HSA-1222523 molecular_function owl:Class
GO:0046805 biolink:NamedThing protein-heme linkage via 1'-L-histidine The covalent linkage of heme and a protein via 1'-L-histidine (otherwise known as tau-heme-histidine, tele-heme-histidine). got7fsn_ti protein-haem linkage via 1'-L-histidine RESID:AA0329 biological_process owl:Class
GO:0023056 biolink:NamedThing positive regulation of signaling Any process that activates, maintains or increases the frequency, rate or extent of a signaling process. got7fsn_ti positive regulation of signalling process|positive regulation of signaling process 2010-02-16T09:30:50Z biological_process owl:Class
GO:0097571 biolink:NamedThing left nucleus One of the two nuclei found in Giardia species (trophozoite stage). It is located on the left side of the cell when viewed from the dorsal side. got7fsn_ti Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-18T11:21:31Z cellular_component owl:Class
GO:0030565 biolink:NamedThing snRNA pseudouridylation guide activity Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. molecular_function owl:Class
GO:0097115 biolink:NamedThing neurexin clustering involved in presynaptic membrane assembly The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals. got7fsn_ti neurexin clustering|Nrxn clustering|presynaptic neurexin clustering pr 2011-07-31T05:40:00Z biological_process owl:Class
GO:0018358 biolink:NamedThing protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine. got7fsn_ti GO:0018381 RESID:AA0133 biological_process owl:Class
GO:0017012 biolink:NamedThing protein-phytochromobilin linkage The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin. got7fsn_ti RESID:AA0133 biological_process owl:Class
GO:0050422 biolink:NamedThing strictosidine beta-glucosidase activity Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = D-glucose + strictosidine aglycone. got7fsn_ti strictosidine b-glucosidase activity|strictosidine beta-D-glucohydrolase activity KEGG_REACTION:R03820|MetaCyc:STRICTOSIDINE-BETA-GLUCOSIDASE-RXN|RHEA:12917|EC:3.2.1.105 molecular_function owl:Class
GO:0070583 biolink:NamedThing spore membrane bending pathway The process in which a bending force is generated in the prospore membrane to form the characteristic curved shape of the prospore. got7fsn_ti forespore membrane bending|FSM bending|ascospore-type prospore membrane bending mah 2009-04-24T10:48:09Z biological_process owl:Class
GO:0072721 biolink:NamedThing cellular response to dithiothreitol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus. got7fsn_ti cellular response to DTT|cellular response to 1,4-dithiothreitol mah 2012-05-09T11:09:08Z biological_process owl:Class
GO:0071734 biolink:NamedThing biotin-[pyruvate-carboxylase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(pyruvate-carboxylase) = AMP + diphosphate + biotin-(pyruvate-carboxylase). got7fsn_ti biotin:apo-pyruvate-carboxylase ligase|biotin-[pyruvate carboxylase] ligase activity|biotin-[pyruvate carboxylase] synthetase activity|biotin-pyruvate-carboxylase ligase activity|biotin-pyruvate carboxylase synthetase activity mah 2010-03-19T02:37:24Z EC:6.3.4.- molecular_function owl:Class
GO:0042081 biolink:NamedThing GSI anchor metabolic process The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane. got7fsn_ti GPI/GSI anchor metabolism|GSI anchor metabolism|GPI/GSI anchor metabolic process biological_process owl:Class
GO:0006687 biolink:NamedThing glycosphingolipid metabolic process The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide. got7fsn_ti glycosphingolipid metabolism biological_process owl:Class
GO:0089700 biolink:NamedThing protein kinase D signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound. got7fsn_ti PKD signaling cascade|protein kinase D signalling cascade|protein kinase D signal transduction|PKD signal transduction|protein kinase D signaling cascade biological_process owl:Class
GO:0031236 biolink:NamedThing extrinsic component of periplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to external side of plasma membrane, in periplasmic space|extrinsic to external leaflet of plasma membrane, in periplasmic space GO:0031238 cellular_component owl:Class
GO:0097097 biolink:NamedThing nasal suture morphogenesis The process in which the nasal suture is generated and organized. got7fsn_ti internasal suture morphogenesis pr 2011-07-05T03:09:04Z biological_process owl:Class
GO:0097096 biolink:NamedThing facial suture morphogenesis The process in which any suture between facial bones is generated and organized. got7fsn_ti pr 2011-07-05T03:06:27Z biological_process owl:Class
GO:0099053 biolink:NamedThing activating signal cointegrator 1 complex A protein complex that contains TRIP4 (ASC1) and acts a transcriptional coactivator by interacting with transcription factors such as NF-kappa B. In humans this complex has 4 subunits: TRIP4 + ASCC1-3. got7fsn_ti ASC-1 complex cellular_component owl:Class
GO:0035962 biolink:NamedThing response to interleukin-13 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. got7fsn_ti response to IL-13 bf 2011-08-01T11:29:02Z biological_process owl:Class
GO:0042365 biolink:NamedThing water-soluble vitamin catabolic process The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water. got7fsn_ti water-soluble vitamin breakdown|water-soluble vitamin catabolism|water-soluble vitamin degradation biological_process owl:Class
GO:0007301 biolink:NamedThing female germline ring canal formation Assembly of the intercellular bridges that connect the germ-line cells of a female cyst. got7fsn_ti nurse cell ring canal formation|ovarian ring canal formation biological_process owl:Class
GO:0030725 biolink:NamedThing germline ring canal formation Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts. got7fsn_ti ring canal formation biological_process owl:Class
GO:0034055 biolink:NamedThing effector-mediated induction of programmed cell death in host A symbiont process in which a molecule secreted by the symbiont activates a programmed cell death pathway in the host to suppress the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti upregulation by symbiont of host defense-related programmed cell death|up regulation by symbiont of host defense-related programmed cell death|enhancement by symbiont of host defense-related programmed cell death|activation by symbiont of host defense-related programmed cell death|stimulation by symbiont of host defense-related programmed cell death|positive regulation by symbiont of host defense-related programmed cell death|up-regulation by symbiont of host defense-related programmed cell death|positive regulation by symbiont of host defense-related PCD https://github.com/geneontology/go-ontology/issues/20284 Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class
GO:0034053 biolink:NamedThing modulation by symbiont of host defense-related programmed cell death Any process in which a symbiont modulates the frequency, rate or extent of defense-related programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host hypersensitive response|modulation by symbiont of host HR|modulation by symbiont of host defense-related PCD|modulation by symbiont of plant HR|modulation by symbiont of plant hypersensitive response Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term 'plant-type hypersensitive response ; GO:0009626'. biological_process owl:Class
GO:0021839 biolink:NamedThing interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex. got7fsn_ti biological_process owl:Class
GO:0023026 biolink:NamedThing MHC class II protein complex binding Binding to a class II major histocompatibility complex. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0033847 biolink:NamedThing O-phosphoserine sulfhydrylase activity Catalysis of the reaction: O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate. got7fsn_ti O-phosphoserine(thiol)-lyase activity|O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity RHEA:10252|EC:2.5.1.65|MetaCyc:2.5.1.65-RXN molecular_function owl:Class
GO:0032571 biolink:NamedThing response to vitamin K Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus. got7fsn_ti biological_process owl:Class
GO:0090442 biolink:NamedThing trehalose catabolism in response to heat stress The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. got7fsn_ti trehalose catabolic process in response to heat stress tb 2012-08-23T13:53:07Z biological_process owl:Class
GO:0010786 biolink:NamedThing clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat. got7fsn_ti biological_process owl:Class
GO:0048202 biolink:NamedThing clathrin coating of Golgi vesicle The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. got7fsn_ti clathrin coating of Golgi-derived vesicle biological_process owl:Class
GO:0042815 biolink:NamedThing bipolar cell growth The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell. got7fsn_ti bipolar growth|polar cell elongation|bipolar cell elongation Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term 'establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246' and its children. biological_process owl:Class
GO:0102687 biolink:NamedThing UDP-glucose:dihydrozeatin 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + dihydrozeatin <=> H+ + dihydrozeatin-7-N-glucose + UDP. got7fsn_ti MetaCyc:RXN-4724 molecular_function owl:Class
GO:0004826 biolink:NamedThing phenylalanine-tRNA ligase activity Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). got7fsn_ti L-phenylalanyl-tRNA synthetase activity|phenylalanyl-tRNA synthetase activity|phenylalanyl-transfer RNA ligase activity|phenylalanyl-tRNA ligase activity|phenylalanine translase activity|phenylalanyl-transfer ribonucleate synthetase activity|L-phenylalanine:tRNAPhe ligase (AMP-forming) activity|phenylalanine-tRNA synthetase activity|phenylalanyl-transfer RNA synthetase activity RHEA:19413|EC:6.1.1.20|MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN|Reactome:R-HSA-380203|Reactome:R-HSA-379848 molecular_function owl:Class
GO:0102487 biolink:NamedThing dUTP phosphohydrolase activity Catalysis of the reaction: dUTP + 2 H2O = dUMP + 2 hydrogenphosphate + 2 H+. got7fsn_ti MetaCyc:RXN-14199|EC:3.6.1.5 molecular_function owl:Class
GO:0008048 biolink:NamedThing calcium sensitive guanylate cyclase activator activity Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. got7fsn_ti molecular_function owl:Class
GO:0030250 biolink:NamedThing guanylate cyclase activator activity Binds to and increases the activity of guanylate cyclase. got7fsn_ti guanylin molecular_function owl:Class
GO:0047832 biolink:NamedThing D-pinitol dehydrogenase activity Catalysis of the reaction: 5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADPH. got7fsn_ti 1D-3-O-methyl-chiro-inositol:NADP+ oxidoreductase activity|5D-5-O-methyl-chiro-inositol:NADP+ oxidoreductase activity KEGG_REACTION:R03498|RHEA:20437|EC:1.1.1.142|MetaCyc:D-PINITOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0008773 biolink:NamedThing [protein-PII] uridylyltransferase activity Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII). got7fsn_ti UTP:[protein-PII] uridylyltransferase activity|UTP:protein-PII uridylyltransferase activity|uridylyl removing enzyme activity|PII uridylyl-transferase activity|protein-PII uridylyltransferase activity|uridyl removing enzyme EC:2.7.7.59|RHEA:13673|MetaCyc:URITRANS-RXN molecular_function owl:Class
GO:0018102 biolink:NamedThing peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine. got7fsn_ti RESID:AA0215 biological_process owl:Class
GO:0030543 biolink:NamedThing 2-micrometer plasmid partitioning The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division. got7fsn_ti biological_process owl:Class
GO:0030541 biolink:NamedThing plasmid partitioning Any process in which plasmids are segregated or distributed into daughter cells upon cell division. got7fsn_ti GO:0030542 biological_process owl:Class
GO:0018107 biolink:NamedThing peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. got7fsn_ti RESID:AA0038 biological_process owl:Class
GO:0035766 biolink:NamedThing cell chemotaxis to fibroblast growth factor The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF). got7fsn_ti bf 2011-03-31T04:30:16Z biological_process owl:Class
GO:0019340 biolink:NamedThing dibenzofuran catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. got7fsn_ti dibenzofuran catabolism|dibenzofuran breakdown|dibenzofuran degradation MetaCyc:P662-PWY biological_process owl:Class
GO:0061852 biolink:NamedThing retrograte transporter complex, Golgi to ER Transporter complex that recognises, binds and returns endoplasmic reticulum (ER) resident proteins that have trafficked to Golgi compartments. Targets proteins lacking the HDEL motif recognised by COPI-coated vesicles. got7fsn_ti ERV41-ERV46 retrograde receptor complex|retrograte receptor complex, Golgi to endoplasmic reticulum|retrograte transporter complex, Golgi to endoplasmic reticulum|retrograte receptor complex, Golgi to ER An example of this is ERV41 in Saccharomyces cerevisiae (Q04651) in PMID:16093310 (inferred from direct assay). dph 2017-02-28T13:56:56Z cellular_component owl:Class
GO:0102524 biolink:NamedThing tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity Catalysis of the reaction: 2-oxoglutarate + O2 + 7-[(3S)-(3-amino-3-carboxypropyl)]-wyosine37 in tRNAPhe = succinate + carbon dioxide + 7-(2-hydroxy-3-amino-3-carboxypropyl)-wyosine37 in tRNAPhe. got7fsn_ti MetaCyc:RXN-14538|RHEA:37899|EC:1.14.11.42 molecular_function owl:Class
GO:0036476 biolink:NamedThing neuron death in response to hydrogen peroxide Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2). got7fsn_ti neuronal cell death in response to hydrogen peroxide|neuron death in response to H2O2|hydrogen peroxide-induced neuron death This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. bf 2014-07-21T11:46:31Z biological_process owl:Class
GO:0036475 biolink:NamedThing neuron death in response to oxidative stress Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus. got7fsn_ti oxidative stress-induced neuron death|neuronal cell death in response to oxidative stress This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0010421 'hydrogen peroxide-mediated programmed cell death'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. bf 2014-07-21T11:44:40Z biological_process owl:Class
GO:0070490 biolink:NamedThing protein pupylation The process in which a Pup protein is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of Pup and the epsilon-amino group of a lysine residue of the target protein. got7fsn_ti Pup-protein conjugation|pupylation biological_process owl:Class
GO:0097145 biolink:NamedThing BAK complex An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:48:11Z cellular_component owl:Class
GO:0106273 biolink:NamedThing cytosol to ERGIC protein transport The directed movement of proteins from the cystosol to the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). got7fsn_ti hjd 2020-07-01T17:28:07Z biological_process owl:Class
GO:0038171 biolink:NamedThing cannabinoid signaling pathway The series of molecular signals generated as a consequence of a cannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. got7fsn_ti cannabinoid-mediated signaling pathway|cannabinoid-activated signaling pathway|cannabinoid receptor signaling pathway bf 2012-06-12T10:47:53Z biological_process owl:Class
GO:0003712 biolink:NamedThing transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. got7fsn_ti transcription cofactor activity|transcriptional co-regulator|RNA polymerase II transcriptional cofactor activity https://github.com/geneontology/go-ontology/issues/15665|https://github.com/geneontology/go-ontology/issues/15998|https://github.com/geneontology/go-ontology/issues/15536|https://github.com/geneontology/go-ontology/issues/20862|https://github.com/geneontology/go-ontology/issues/20464|https://github.com/geneontology/go-ontology/issues/20962|https://github.com/geneontology/go-ontology/issues/20253 Usage guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity. krc 2010-11-24T03:02:15Z GO:0001104|GO:0016455 molecular_function owl:Class
GO:0009244 biolink:NamedThing lipopolysaccharide core region biosynthetic process The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. got7fsn_ti lipopolysaccharide core region biosynthesis|LPS core region biosynthetic process|lipopolysaccharide core region anabolism|lipopolysaccharide core region formation|lipopolysaccharide core region synthesis biological_process owl:Class
GO:0046401 biolink:NamedThing lipopolysaccharide core region metabolic process The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. The structure of this core oligosaccharide appears to be similar in closely related bacterial strains. got7fsn_ti LPS core region metabolic process|lipopolysaccharide core region metabolism biological_process owl:Class
GO:0071339 biolink:NamedThing MLL1 complex A protein complex that can methylate lysine-4 of histone H3. MLL1/MLL is the catalytic methyltransferase subunit, and the complex also contains the core components ASH2L, HCFC1/HCF1 WDR5 and RBBP5. got7fsn_ti mah 2009-12-11T11:11:36Z cellular_component owl:Class
GO:0044665 biolink:NamedThing MLL1/2 complex A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species. got7fsn_ti Trx-containing complex jl 2012-08-07T14:44:12Z cellular_component owl:Class
GO:0097528 biolink:NamedThing execution phase of necroptosis A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died. got7fsn_ti necroptotic execution phase|execution phase of necroptotic process|necroptosis pr 2013-11-05T14:23:53Z biological_process owl:Class
GO:0021877 biolink:NamedThing forebrain neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain. got7fsn_ti biological_process owl:Class
GO:0018189 biolink:NamedThing pyrroloquinoline quinone biosynthetic process The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed. got7fsn_ti coenzyme pyrroloquinoline-quinone biosynthesis|pyrroloquinoline quinone biosynthesis|pyrroloquinoline quinone anabolism|pyrroloquinoline quinone formation|PQQ biosynthetic process|PQQ biosynthesis|pyrroloquinoline-quinone biosynthesis|coenzyme pyrroloquinoline-quinone biosynthetic process|pyrroloquinoline quinone synthesis|pyrroloquinoline-quinone biosynthetic process https://github.com/geneontology/go-ontology/issues/20547 RESID:AA0283 biological_process owl:Class
GO:0002772 biolink:NamedThing inhibitory C-type lectin receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response. got7fsn_ti Ly49 inhibitory receptor signaling pathway|inhibitory C-type lectin receptor signalling pathway biological_process owl:Class
GO:0032836 biolink:NamedThing glomerular basement membrane development The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration. got7fsn_ti biological_process owl:Class
GO:0098627 biolink:NamedThing protein arginine phosphatase activity Catalysis of the reaction: protein arginine phosphate + H2O = protein arginine + phosphate. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21517 Made part of peptidyl-N-phospho-arginine phosphatase activity on the assumption that arginine phosphorylation in proteins occurs via an N link. dos 2014-04-17T17:57:39Z EC:3.9.1.2|RHEA:43380 molecular_function owl:Class
GO:0016825 biolink:NamedThing hydrolase activity, acting on acid phosphorus-nitrogen bonds Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond. got7fsn_ti EC:3.9.1.- molecular_function owl:Class
GO:0047833 biolink:NamedThing D-sorbitol dehydrogenase (acceptor) activity Catalysis of the reaction: D-sorbitol + acceptor = L-sorbose + reduced acceptor. got7fsn_ti D-sorbitol:acceptor 1-oxidoreductase activity|D-sorbitol dehydrogenase activity|D-sorbitol:(acceptor) 1-oxidoreductase activity RHEA:21320|MetaCyc:D-SORBITOL-DEHYDROGENASE-RXN|EC:1.1.99.21 molecular_function owl:Class
GO:0034901 biolink:NamedThing endosulfan hydroxyether dehydrogenase activity Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1411 molecular_function owl:Class
GO:0070591 biolink:NamedThing ascospore wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall. got7fsn_ti mah 2009-04-28T01:12:11Z biological_process owl:Class
GO:0009272 biolink:NamedThing fungal-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin. got7fsn_ti fungal-type cell wall anabolism|fungal-type cell wall biosynthetic process|fungal-type cell wall synthesis|fungal-type cell wall formation|chitin- and beta-glucan-containing cell wall biogenesis biological_process owl:Class
GO:0007305 biolink:NamedThing vitelline membrane formation involved in chorion-containing eggshell formation Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster. got7fsn_ti vitelline membrane formation in chorion-containing eggshell biological_process owl:Class
GO:0030704 biolink:NamedThing vitelline membrane formation Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg. got7fsn_ti biological_process owl:Class
GO:0016223 biolink:NamedThing beta-alanine-pyruvate transaminase activity Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine. got7fsn_ti beta-alanine--pyruvate aminotransferase activity|L-alanine:3-oxopropanoate aminotransferase activity|omega-amino acid--pyruvate aminotransferase activity|beta-alanine-pyruvate aminotransferase activity|beta-alanine-alpha-alanine transaminase activity EC:2.6.1.18|RHEA:14077|MetaCyc:2.6.1.18-RXN|Reactome:R-HSA-909776 molecular_function owl:Class
GO:0036278 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen. got7fsn_ti bf 2012-07-11T11:02:55Z biological_process owl:Class
GO:0060537 biolink:NamedThing muscle tissue development The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers. got7fsn_ti dph 2009-04-10T08:05:37Z biological_process owl:Class
GO:0047935 biolink:NamedThing glucose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH. got7fsn_ti nicotinamide adenine dinucleotide phosphate-linked aldohexose dehydrogenase activity|D-glucose:NADP+ 1-oxidoreductase activity|NADP-linked aldohexose dehydrogenase activity|NADP-dependent glucose dehydrogenase activity MetaCyc:GLUCOSE-1-DEHYDROGENASE-NADP+-RXN|EC:1.1.1.119|RHEA:14405 molecular_function owl:Class
GO:0047936 biolink:NamedThing glucose 1-dehydrogenase [NAD(P)] activity Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H. got7fsn_ti beta-D-glucose:NAD(P)+ 1-oxidoreductase activity|D-glucose dehydrogenase (NAD(P))|hexose phosphate dehydrogenase activity MetaCyc:GLUCOSE-1-DEHYDROGENASE-RXN|EC:1.1.1.47 molecular_function owl:Class
GO:0060714 biolink:NamedThing labyrinthine layer formation The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta. got7fsn_ti dph 2009-06-10T08:13:14Z biological_process owl:Class
GO:0008816 biolink:NamedThing citryl-CoA lyase activity Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate. got7fsn_ti (3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)|(3S)-citryl-CoA oxaloacetate-lyase activity RHEA:20812|MetaCyc:CITRYLY-RXN|EC:4.1.3.34 molecular_function owl:Class
GO:0061536 biolink:NamedThing glycine secretion The controlled release of glycine by a cell. got7fsn_ti dph 2013-06-21T16:18:23Z biological_process owl:Class
GO:0032940 biolink:NamedThing secretion by cell The controlled release of a substance by a cell. got7fsn_ti cellular secretion Wikipedia:Secretion biological_process owl:Class
GO:0097598 biolink:NamedThing sperm cytoplasmic droplet A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce what are called residual bodies. Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from 'excessive residual cytoplasm' that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted. got7fsn_ti sperm residual cytoplasm pr 2014-04-10T14:03:30Z cellular_component owl:Class
GO:0048798 biolink:NamedThing swim bladder inflation The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. got7fsn_ti gas bladder inflation biological_process owl:Class
GO:0047714 biolink:NamedThing galactolipase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + 2 H2O = 3-beta-D-galactosyl-sn-glycerol + 2 carboxylates. got7fsn_ti galactolipid lipase activity|polygalactolipase activity|galactolipid acylhydrolase activity|1,2-diacyl-3-beta-D-galactosyl-sn-glycerol acylhydrolase activity EC:3.1.1.26|RHEA:13189|MetaCyc:GALACTOLIPASE-RXN molecular_function owl:Class
GO:0103003 biolink:NamedThing oleate peroxygenase activity Catalysis of the reaction: oleate + a lipid hydroperoxide <=> 9,10-epoxystearate + a lipid alcohol. got7fsn_ti MetaCyc:RXN-9804 molecular_function owl:Class
GO:0016684 biolink:NamedThing oxidoreductase activity, acting on peroxide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. got7fsn_ti EC:1.11.-.- molecular_function owl:Class
GO:0070398 biolink:NamedThing wall teichoic acid biosynthetic process The chemical reactions and pathways resulting in the formation of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. got7fsn_ti wall teichoic acid anabolism|wall teichoic acid synthesis|wall teichoic acid formation|WTA biosynthetic process|wall teichoic acid biosynthesis biological_process owl:Class
GO:0004054 biolink:NamedThing arginine kinase activity Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+). got7fsn_ti ATP:L-arginine N-phosphotransferase activity|adenosine 5'-triphosphate:L-arginine|adenosine 5'-triphosphate-arginine phosphotransferase activity|arginine phosphokinase activity KEGG_REACTION:R00554|RHEA:22940|EC:2.7.3.3|MetaCyc:ARGININE-KINASE-RXN molecular_function owl:Class
GO:0019202 biolink:NamedThing amino acid kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate. got7fsn_ti molecular_function owl:Class
GO:0036492 biolink:NamedThing eiF2alpha phosphorylation in response to endoplasmic reticulum stress The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress. got7fsn_ti regulation of translation initiation by eiF2alpha phosphorylation in response to endoplasmic reticulum stress|eiF2alpha phosphorylation in response to ER stress bf 2015-02-05T09:53:21Z biological_process owl:Class
GO:0036491 biolink:NamedThing regulation of translation initiation in response to endoplasmic reticulum stress Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress. got7fsn_ti regulation of translation initiation in response to ER stress bf 2015-02-05T09:52:13Z biological_process owl:Class
GO:0071805 biolink:NamedThing potassium ion transmembrane transport A process in which a potassium ion is transported from one side of a membrane to the other. got7fsn_ti high-affinity potassium ion import|high-affinity potassium ion uptake|high affinity potassium ion uptake|high affinity potassium ion import|potassium ion membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-09-03T02:43:49Z GO:0010163 biological_process owl:Class
GO:0034424 biolink:NamedThing Vps55/Vps68 complex A membrane-associated protein complex that is required for a late stage of endosomal transport. In budding yeast, this complex consists of Vps55p and Vps68p proteins. got7fsn_ti cellular_component owl:Class
GO:0035167 biolink:NamedThing larval lymph gland hemopoiesis The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. got7fsn_ti larval lymph gland haematopoiesis|larval lymph gland hematopoiesis|larval lymph gland haemopoiesis biological_process owl:Class
GO:0035166 biolink:NamedThing post-embryonic hemopoiesis The stages of blood cell formation that take place after completion of embryonic development. got7fsn_ti post-embryonic haemopoiesis biological_process owl:Class
GO:0120160 biolink:NamedThing intraciliary transport particle A binding Binding to an intraciliary transport particle A (IFT A) complex. got7fsn_ti intraflagellar transport particle A binding|intraflagellar transport complex A binding|intraciliary transport complex A binding|IFT A complex binding krc 2018-05-11T22:28:11Z molecular_function owl:Class
GO:0070212 biolink:NamedThing protein poly-ADP-ribosylation The transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. got7fsn_ti addition of poly-ADP-ribose to protein|protein amino acid poly-ADP-ribosylation|poly(ADP-ribose) addition to protein|protein poly(ADP-ribose) synthesis|protein poly(ADP-ribose) metabolism biological_process owl:Class
GO:0002086 biolink:NamedThing diaphragm contraction A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange. got7fsn_ti biological_process owl:Class
GO:0003016 biolink:NamedThing respiratory system process A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange. got7fsn_ti respiratory gaseous exchange GO:0010802 biological_process owl:Class
GO:0044036 biolink:NamedThing cell wall macromolecule metabolic process The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. got7fsn_ti cellular cell wall macromolecule metabolism|cellular cell wall macromolecule metabolic process GO:0010382 biological_process owl:Class
GO:0045815 biolink:NamedThing positive regulation of gene expression, epigenetic Any epigenetic process that activates or increases the rate of gene expression. got7fsn_ti stimulation of gene expression, epigenetic|up regulation of gene expression, epigenetic|up-regulation of gene expression, epigenetic|upregulation of gene expression, epigenetic|activation of gene expression, epigenetic|long-term maintenance of gene activation biological_process owl:Class
GO:0019883 biolink:NamedThing antigen processing and presentation of endogenous antigen The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex. got7fsn_ti antigen presentation, endogenous antigen biological_process owl:Class
GO:0043562 biolink:NamedThing cellular response to nitrogen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen. got7fsn_ti biological_process owl:Class
GO:0001692 biolink:NamedThing histamine metabolic process The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. got7fsn_ti histamine metabolism biological_process owl:Class
GO:0052803 biolink:NamedThing imidazole-containing compound metabolic process The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. got7fsn_ti imidazole metabolism biological_process owl:Class
GO:1990983 biolink:NamedThing tRNA demethylation The removal of a methyl group from one or more residues within a tRNA molecule. got7fsn_ti sp 2016-10-28T08:32:59Z biological_process owl:Class
GO:0009503 biolink:NamedThing thylakoid light-harvesting complex A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana. got7fsn_ti cellular_component owl:Class
GO:0051638 biolink:NamedThing barbed-end actin filament uncapping The removal of capping protein from the barbed (or plus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. got7fsn_ti plus end actin filament uncapping|plus end F-actin uncapping|barbed end F-actin uncapping|barbed end actin filament uncapping|plus-end F-actin uncapping|plus-end actin filament uncapping|barbed-end F-actin uncapping biological_process owl:Class
GO:0051695 biolink:NamedThing actin filament uncapping The removal of capping protein from the end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. got7fsn_ti F-actin uncapping biological_process owl:Class
GO:0031175 biolink:NamedThing neuron projection development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). got7fsn_ti neurite outgrowth|neurite growth|neurite development|neurite biosynthesis|neurite formation biological_process owl:Class
GO:0071380 biolink:NamedThing cellular response to prostaglandin E stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. got7fsn_ti mah 2009-12-11T03:34:43Z biological_process owl:Class
GO:0034695 biolink:NamedThing response to prostaglandin E Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus. got7fsn_ti response to prostaglandin E stimulus biological_process owl:Class
GO:0072053 biolink:NamedThing renal inner medulla development The process whose specific outcome is the progression of the renal inner medulla over time, from its formation to the mature structure. The renal inner medulla is unique to mammalian kidneys and is the innermost region of the mammalian kidney. got7fsn_ti inner renal medulla development mah 2010-01-25T03:59:37Z biological_process owl:Class
GO:0018591 biolink:NamedThing methyl tertiary butyl ether 3-monooxygenase activity Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde. got7fsn_ti MTBE 3-monooxygenase activity molecular_function owl:Class
GO:0030322 biolink:NamedThing stabilization of membrane potential The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti biological_process owl:Class
GO:0070665 biolink:NamedThing positive regulation of leukocyte proliferation Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. got7fsn_ti upregulation of leukocyte proliferation|up regulation of leukocyte proliferation|up-regulation of leukocyte proliferation|stimulation of leukocyte proliferation|activation of leukocyte proliferation mah 2009-05-28T05:36:46Z biological_process owl:Class
GO:0008284 biolink:NamedThing positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation. got7fsn_ti activation of cell proliferation|up regulation of cell proliferation|up-regulation of cell proliferation|positive regulation of cell proliferation|upregulation of cell proliferation|stimulation of cell proliferation biological_process owl:Class
GO:0042772 biolink:NamedThing DNA damage response, signal transduction resulting in transcription A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription. got7fsn_ti biological_process owl:Class
GO:0061891 biolink:NamedThing calcium ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+). got7fsn_ti dph 2017-06-01T23:37:01Z molecular_function owl:Class
GO:0070620 biolink:NamedThing EGFR-Grb2-Sos complex A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. got7fsn_ti Egfr-Grb2-mSos1 complex, EGF stimulated mah 2009-04-29T04:36:30Z cellular_component owl:Class
GO:0031518 biolink:NamedThing CBF3 complex A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p. got7fsn_ti cellular_component owl:Class
GO:0048169 biolink:NamedThing regulation of long-term neuronal synaptic plasticity A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. got7fsn_ti Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:1990869 biolink:NamedThing cellular response to chemokine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus. got7fsn_ti sl 2015-09-25T16:39:55Z biological_process owl:Class
GO:0043503 biolink:NamedThing skeletal muscle fiber adaptation Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. got7fsn_ti skeletal myofiber plasticity|skeletal muscle fiber plasticity|skeletal myofibre plasticity|skeletal muscle fibre plasticity biological_process owl:Class
GO:0006265 biolink:NamedThing DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. got7fsn_ti DNA underwinding Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo. biological_process owl:Class
GO:0002944 biolink:NamedThing cyclin K-CDK12 complex A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti CycK/Cdk12 complex hjd 2012-12-05T16:09:48Z cellular_component owl:Class
GO:0030680 biolink:NamedThing dimeric ribonuclease P complex A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species. got7fsn_ti dimeric RNase P complex cellular_component owl:Class
GO:0072584 biolink:NamedThing caveolin-mediated endocytosis An endocytosis process that begins when material is taken up into plasma membrane caveolae, which then pinch off to form endocytic caveolar carriers. got7fsn_ti caveolae-dependent endocytosis|caveolae-mediated endocytosis|caveolin-dependent endocytosis mah 2011-02-08T04:08:33Z biological_process owl:Class
GO:0006897 biolink:NamedThing endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. got7fsn_ti vesicle endocytosis|nonselective vesicle endocytosis|plasma membrane invagination|endocytic import into cell GO:0016196|GO:0098701|GO:0016193 Wikipedia:Endocytosis biological_process owl:Class
GO:0033201 biolink:NamedThing alpha-1,4-glucan synthase activity Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP. got7fsn_ti 1,4-alpha-glucan synthase activity EC:2.4.1.21|RHEA:18189 molecular_function owl:Class
GO:0000461 biolink:NamedThing endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. got7fsn_ti endonucleolytic cleavage at site D biological_process owl:Class
GO:0031949 biolink:NamedThing regulation of glucocorticoid catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. got7fsn_ti biological_process owl:Class
GO:0018415 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide RESID:AA0292 biological_process owl:Class
GO:0032810 biolink:NamedThing sterol response element binding Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism. got7fsn_ti SRE binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. molecular_function owl:Class
GO:0061728 biolink:NamedThing GDP-mannose biosynthetic process from mannose The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose. got7fsn_ti dph 2015-07-24T14:44:04Z biological_process owl:Class
GO:0009298 biolink:NamedThing GDP-mannose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. got7fsn_ti GDP-mannose biosynthesis|GDP-mannose anabolism|GDP-mannose synthesis|GDP-mannose formation biological_process owl:Class
GO:0018535 biolink:NamedThing nicotine dehydrogenase activity Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor. got7fsn_ti nicotine:acceptor 6-oxidoreductase (hydroxylating)|nicotine oxidase activity|D-nicotine oxidase activity|nicotine:(acceptor) 6-oxidoreductase (hydroxylating) EC:1.5.99.4|MetaCyc:NICOTINE-DEHYDROGENASE-RXN|RHEA:14769|UM-BBD_enzymeID:e0337 molecular_function owl:Class
GO:0072383 biolink:NamedThing plus-end-directed vesicle transport along microtubule The directed movement of a vesicle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. got7fsn_ti microtubule plus-end-directed vesicle localization|microtubule plus-end-directed vesicle distribution mah 2010-12-01T04:24:51Z biological_process owl:Class
GO:0047496 biolink:NamedThing vesicle transport along microtubule The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. got7fsn_ti microtubule-based vesicle localization biological_process owl:Class
GO:0019914 biolink:NamedThing cyclin-dependent protein kinase activating kinase regulator activity Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase. got7fsn_ti cyclin-dependent protein kinase activating kinase, intrinsic regulator activity EC:2.7.1.- molecular_function owl:Class
GO:0030728 biolink:NamedThing ovulation The release of a mature ovum/oocyte from an ovary. got7fsn_ti Wikipedia:Ovulation biological_process owl:Class
GO:0043399 biolink:NamedThing tRNA A64-2'-O-ribosylphosphate transferase activity Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA. got7fsn_ti initiator tRNA phosphoribosyl-transferase activity molecular_function owl:Class
GO:0050456 biolink:NamedThing cystine reductase activity Catalysis of the reaction: 2 L-cysteine + NAD(+) = L-cystine + H(+) + NADH. got7fsn_ti NADH:L-cystine oxidoreductase activity|cystine reductase (NADH2)|NADH2:L-cystine oxidoreductase|NADH-dependent cystine reductase activity|L-cysteine:NAD+ oxidoreductase|cystine reductase (NADH) activity MetaCyc:CYSTINE-REDUCTASE-NADH-RXN|KEGG_REACTION:R00892|EC:1.8.1.6|RHEA:20597 molecular_function owl:Class
GO:0031118 biolink:NamedThing rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0033891 biolink:NamedThing CC-preferring endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage to give 5'-phosphooligonucleotide end-products, with a preference for cleavage within the sequence CC. got7fsn_ti Streptomyces glaucescens exocytoplasmic endodeoxyribonuclease activity|Streptomyces glaucescens exocytoplasmic dodeoxyribonuclease activity|5'-CC-3'-preferring endodeoxyribonuclease activity|Streptomyces glaucescens exocytoplasmic endonuclease activity MetaCyc:3.1.21.6-RXN|EC:3.1.21.6 molecular_function owl:Class
GO:0072092 biolink:NamedThing ureteric bud invasion The process in which the ureteric bud grows along its axis and contributes to the formation of the metanephros. got7fsn_ti mah 2010-02-10T01:15:13Z biological_process owl:Class
GO:0034511 biolink:NamedThing U3 snoRNA binding Binding to a U3 small nucleolar RNA. got7fsn_ti molecular_function owl:Class
GO:0008115 biolink:NamedThing sarcosine oxidase activity Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2). got7fsn_ti sarcosine:oxygen oxidoreductase (demethylating) EC:1.5.3.1|RHEA:13313|KEGG_REACTION:R00610|MetaCyc:SARCOX-RXN molecular_function owl:Class
GO:0060209 biolink:NamedThing estrus The estrous cycle phase in which a female is sexually receptive. got7fsn_ti oestrus Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0005737 biolink:NamedThing cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. got7fsn_ti Wikipedia:Cytoplasm cellular_component owl:Class
GO:0047824 biolink:NamedThing D-iditol 2-dehydrogenase activity Catalysis of the reaction: D-iditol + NAD+ = D-sorbose + NADH. got7fsn_ti EC:1.1.1.15|MetaCyc:D-IDITOL-2-DEHYDROGENASE-RXN|RHEA:12725 molecular_function owl:Class
GO:0061782 biolink:NamedThing vesicle fusion with vesicle Fusion of the membrane of a transport vesicle with a target membrane on another vesicle. got7fsn_ti vesicle to vesicle fusion|vesicle-vesicle fusion dph 2016-09-06T13:29:49Z biological_process owl:Class
GO:0008798 biolink:NamedThing beta-aspartyl-peptidase activity Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide. got7fsn_ti beta-aspartyl dipeptidase activity|beta-aspartyl peptidase activity Reactome:R-HSA-5692495|EC:3.4.19.5|MetaCyc:3.4.19.5-RXN|Reactome:R-HSA-5696365 molecular_function owl:Class
GO:0070003 biolink:NamedThing threonine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. got7fsn_ti molecular_function owl:Class
GO:0102947 biolink:NamedThing (+)-delta-cadinene-8-hydroxylase activity Catalysis of the reaction: H+ + (+)-delta-cadinene + NADPH + O2 <=> 8-hydroxy-(+)-delta-cadinene + NADP + H2O. got7fsn_ti MetaCyc:RXN-9045 molecular_function owl:Class
GO:0021785 biolink:NamedThing branchiomotor neuron axon guidance The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti branchial motor axon guidance|BMN axon guidance|special visceral motor neuron axon guidance biological_process owl:Class
GO:0008045 biolink:NamedThing motor neuron axon guidance The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti motoneuron axon guidance|motor axon pathfinding|motor axon guidance biological_process owl:Class
GO:0099590 biolink:NamedThing neurotransmitter receptor internalization A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor. got7fsn_ti biological_process owl:Class
GO:0007289 biolink:NamedThing spermatid nucleus differentiation The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization. got7fsn_ti spermatid nuclear differentiation See also the Cell Ontology term 'spermatid ; CL:0000018'. biological_process owl:Class
GO:0008263 biolink:NamedThing pyrimidine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site. got7fsn_ti G/T-mismatch-specific thymine-DNA glycosylase activity molecular_function owl:Class
GO:0031037 biolink:NamedThing myosin II filament disassembly The disassembly of a bipolar filament composed of myosin II molecules. got7fsn_ti myosin II depolymerization biological_process owl:Class
GO:0047434 biolink:NamedThing indolepyruvate decarboxylase activity Catalysis of the reaction: indolepyruvate = CO2 + indole acetaldehyde. got7fsn_ti indole-3-pyruvate decarboxylase activity|3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]|3-(indol-3-yl)pyruvate carboxy-lyase activity|indol-3-yl-pyruvate carboxy-lyase activity EC:4.1.1.74|MetaCyc:4.1.1.74-RXN|RHEA:18017 molecular_function owl:Class
GO:0001059 biolink:NamedThing transcription by RNA polymerase IV The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter. got7fsn_ti transcription from RNA polymerase IV promoter|transcription from RNA pol IV promoter https://github.com/geneontology/go-ontology/issues/14854 krc 2010-09-23T03:51:35Z biological_process owl:Class
GO:0035648 biolink:NamedThing circadian mating behavior The fluctuation in mating behavior that occurs over an approximately 24 hour cycle. got7fsn_ti circadian mating behaviour|circadian mating rhythm bf 2011-01-25T10:20:05Z biological_process owl:Class
GO:0046968 biolink:NamedThing peptide antigen transport The directed movement of a peptide antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein. got7fsn_ti biological_process owl:Class
GO:0050532 biolink:NamedThing 2-phosphosulfolactate phosphatase activity Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H(2)O = (R)-3-sulfolactate + phosphate. got7fsn_ti 2-phosphosulpholactate phosphatase activity|(2R)-phosphosulfolactate phosphohydrolase activity|ComB phosphatase activity|(R)-2-phospho-3-sulfolactate phosphohydrolase activity MetaCyc:R229-RXN|RHEA:23416|EC:3.1.3.71|KEGG_REACTION:R05789 molecular_function owl:Class
GO:0046184 biolink:NamedThing aldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O. got7fsn_ti aldehyde biosynthesis|aldehyde formation|aldehyde synthesis|aldehyde anabolism biological_process owl:Class
GO:0042789 biolink:NamedThing mRNA transcription by RNA polymerase II The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. got7fsn_ti mRNA transcription from Pol II promoter|mRNA transcription from RNA polymerase II promoter https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0061784 biolink:NamedThing peptidoglycan N-acetylglucosaminidase activity Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan. got7fsn_ti dph 2016-09-07T16:17:03Z molecular_function owl:Class
GO:0044599 biolink:NamedThing AP-5 adaptor complex An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo. got7fsn_ti adaptor protein-5 adaptor complex jl 2012-05-01T03:48:11Z cellular_component owl:Class
GO:0102240 biolink:NamedThing soyasapogenol B glucuronide galactosyltransferase activity Catalysis of the reaction: UDP-D-galactose + soyasapogenol B 3-O-beta-glucuronate <=> H+ + UDP + soyasaponin III. got7fsn_ti MetaCyc:RXN-12319|EC:2.4.1.272|RHEA:31487 molecular_function owl:Class
GO:0000342 biolink:NamedThing RNA cap 4 binding Binding to a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa. got7fsn_ti molecular_function owl:Class
GO:0000339 biolink:NamedThing RNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. got7fsn_ti snRNA cap binding|binding to mRNA cap|mRNA cap binding molecular_function owl:Class
GO:0034476 biolink:NamedThing U5 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U5 snRNA molecule. got7fsn_ti U5 snRNA 3' end processing biological_process owl:Class
GO:0034472 biolink:NamedThing snRNA 3'-end processing Any process involved in forming the mature 3' end of an snRNA molecule. got7fsn_ti snRNA 3' end processing biological_process owl:Class
GO:0075038 biolink:NamedThing negative regulation of appressorium maturation Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium maturation. got7fsn_ti negative regulation of appressorium maturation on or near host|negative regulation of maturation of appressorium on or near host biological_process owl:Class
GO:0075019 biolink:NamedThing negative regulation of appressorium formation Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont appressorium formation. got7fsn_ti negative regulation of appressorium formation on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0099022 biolink:NamedThing vesicle tethering The initial, indirect interaction between a vesicle membrane and a membrane to which it is targeted for fusion. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to interaction between factors involved in fusion. got7fsn_ti biological_process owl:Class
GO:0046424 biolink:NamedThing ferulate 5-hydroxylase activity Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+. got7fsn_ti MetaCyc:RXN-1121 molecular_function owl:Class
GO:0004085 biolink:NamedThing butyryl-CoA dehydrogenase activity Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein. got7fsn_ti butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity|unsaturated acyl-CoA reductase activity|butyryl dehydrogenase activity|butanoyl-CoA:acceptor 2,3-oxidoreductase activity|unsaturated acyl coenzyme A reductase activity|short-chain acyl-coenzyme A dehydrogenase activity|3-hydroxyacyl CoA reductase activity|enoyl-coenzyme A reductase activity|short-chain-acyl-CoA dehydrogenase activity|ethylene reductase activity|butyryl coenzyme A dehydrogenase activity|short-chain acyl CoA dehydrogenase activity EC:1.3.8.1|MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN|UM-BBD_reactionID:r0013|KEGG_REACTION:R01178 molecular_function owl:Class
GO:0047114 biolink:NamedThing kynurenate-7,8-dihydrodiol dehydrogenase activity Catalysis of the reaction: 7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + H(+) + NADH. got7fsn_ti 7,8-dihydro-7,8-dihydroxykynurenate:NAD+ oxidoreductase activity|7,8-dihydroxykynurenic acid 7,8-diol dehydrogenase activity|7,8-dihydro-7,8-dihydroxykynurenate dehydrogenase activity EC:1.3.1.18|MetaCyc:1.3.1.18-RXN|KEGG_REACTION:R03251|RHEA:22248 molecular_function owl:Class
GO:0052625 biolink:NamedThing 4-aminobenzoate amino acid synthetase activity Catalysis of the reaction: 4-aminobenzoate + ATP + amino acid = 4-aminobenzoyl amino acid conjugate + AMP + diphosphate. got7fsn_ti pABA amino acid synthetase activity|4-aminobenzoyl amino acid synthetase activity|p-aminobenzoyl amino acid synthetase activity|p-aminobenzoate amino acid synthetase activity molecular_function owl:Class
GO:0015924 biolink:NamedThing mannosyl-oligosaccharide mannosidase activity Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. got7fsn_ti EC:3.2.1.- molecular_function owl:Class
GO:0072686 biolink:NamedThing mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. got7fsn_ti mah 2011-07-08T05:08:16Z cellular_component owl:Class
GO:0005819 biolink:NamedThing spindle The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. got7fsn_ti Wikipedia:Spindle_apparatus cellular_component owl:Class
GO:0002041 biolink:NamedThing intussusceptive angiogenesis The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars. got7fsn_ti biological_process owl:Class
GO:0034328 biolink:NamedThing decanoyltransferase activity Catalysis of the transfer of a decanoyl (CH3-[CH2]8-CO-) group to an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0044387 biolink:NamedThing negative regulation of protein kinase activity by regulation of protein phosphorylation The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase. got7fsn_ti jl 2011-12-13T04:49:36Z biological_process owl:Class
GO:0006469 biolink:NamedThing negative regulation of protein kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity. got7fsn_ti downregulation of protein kinase activity|inhibition of protein kinase activity|down-regulation of protein kinase activity|down regulation of protein kinase activity biological_process owl:Class
GO:0071669 biolink:NamedThing plant-type cell wall organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall. got7fsn_ti plant-type cell wall organisation or biogenesis|plant-type cell wall organization and biogenesis mah 2010-02-15T02:32:10Z biological_process owl:Class
GO:0008121 biolink:NamedThing ubiquinol-cytochrome-c reductase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. got7fsn_ti complex III (mitochondrial electron transport) activity|ubiquinol-cytochrome c2 reductase activity|cytochrome|electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity|electron transporter, transferring electrons within cytochrome c oxidase complex activity|ubiquinol-cytochrome c-2 oxidoreductase activity|ubiquinol:ferricytochrome-c oxidoreductase activity|cytochrome a3/copper complex|mitochondrial electron transport complex III|ubiquinol-cytochrome c oxidoreductase activity|ubiquinone-cytochrome c reductase activity|ubiquinol-cytochrome c1 oxidoreductase activity|cytochrome b562|soluble cytochrome b562|cytochrome b566|ubiquinone--cytochrome-c oxidoreductase activity|cytochrome a|cytochrome c1|ubiquinone-cytochrome c oxidoreductase activity https://github.com/geneontology/go-ontology/issues/21275|https://github.com/geneontology/go-ontology/issues/20616 GO:0045154|GO:0045153 EC:7.1.1.8|Reactome:R-HSA-164651|MetaCyc:1.10.2.2-RXN|RHEA:11484 molecular_function owl:Class
GO:0050024 biolink:NamedThing L-galactonolactone oxidase activity Catalysis of the reaction: L-galactono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2) + H(+). got7fsn_ti L-xylono-1,4-lactone oxidase activity|L-galactono-1,4-lactone oxidase activity|L-galactono-1,4-lactone:oxygen 3-oxidoreductase activity GO:0033733 KEGG_REACTION:R00643|MetaCyc:1.3.3.12-RXN|EC:1.3.3.12|RHEA:20617 molecular_function owl:Class
GO:0060612 biolink:NamedThing adipose tissue development The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. got7fsn_ti adipogenesis dph 2009-05-15T12:36:28Z biological_process owl:Class
GO:0048255 biolink:NamedThing mRNA stabilization Prevention of degradation of mRNA molecules. In the absence of compensating changes in other processes, the slowing of mRNA degradation can result in an overall increase in the population of active mRNA molecules. got7fsn_ti biological_process owl:Class
GO:0043489 biolink:NamedThing RNA stabilization Prevention of degradation of RNA molecules. got7fsn_ti biological_process owl:Class
GO:0048829 biolink:NamedThing root cap development The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant. got7fsn_ti biological_process owl:Class
GO:0030889 biolink:NamedThing negative regulation of B cell proliferation Any process that stops, prevents or reduces the rate or extent of B cell proliferation. got7fsn_ti negative regulation of B lymphocyte proliferation|negative regulation of B-lymphocyte proliferation|downregulation of B cell proliferation|negative regulation of B-cell proliferation|down regulation of B cell proliferation|down-regulation of B cell proliferation|inhibition of B cell proliferation biological_process owl:Class
GO:0044659 biolink:NamedThing viral release from host cell by cytolysis The killing by a virus of a cell by means of the rupture of cell membranes and the loss of cytoplasm. got7fsn_ti viral release by host cell lysis|cytolysis by virus of host cell|lytic viral release|viral exit from host cell by cytolysis|viral release by cell lysis|lytic viral life cycle https://github.com/geneontology/go-ontology/issues/18852 jl 2012-08-01T13:16:39Z GO:0046756|GO:0019077 VZ:1077 biological_process owl:Class
GO:0031810 biolink:NamedThing H4 histamine receptor binding Binding to a H4 histamine receptor. got7fsn_ti H4 histamine receptor ligand molecular_function owl:Class
GO:0033404 biolink:NamedThing UUG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UUG codon. got7fsn_ti leucine tRNA|TTG codon-amino acid adaptor activity Note that in the standard genetic code, TTG codes for leucine. molecular_function owl:Class
GO:0102843 biolink:NamedThing 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity (SN2-16:1 forming) Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti RHEA:46756|MetaCyc:RXN-8304|EC:1.14.19.42 molecular_function owl:Class
GO:0039614 biolink:NamedThing induction by virus of host protein phosphorylation Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host. got7fsn_ti bf 2012-07-06T11:15:56Z biological_process owl:Class
GO:0001934 biolink:NamedThing positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. got7fsn_ti positive regulation of protein amino acid phosphorylation|activation of protein amino acid phosphorylation|stimulation of protein amino acid phosphorylation|up-regulation of protein amino acid phosphorylation|upregulation of protein amino acid phosphorylation|up regulation of protein amino acid phosphorylation biological_process owl:Class
GO:0106141 biolink:NamedThing flavin prenyltransferase activity Catalysis of the reaction: dimethylallylphosphate + FMNH2 = prenylated FMNH2 + phosphate. got7fsn_ti hjd 2018-08-17T18:50:00Z RHEA:37743|EC:2.5.1.129 molecular_function owl:Class
GO:0009890 biolink:NamedThing negative regulation of biosynthetic process Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances. got7fsn_ti inhibition of biosynthetic process|negative regulation of biosynthesis|negative regulation of formation|down regulation of biosynthetic process|negative regulation of anabolism|downregulation of biosynthetic process|down-regulation of biosynthetic process|negative regulation of synthesis biological_process owl:Class
GO:0009892 biolink:NamedThing negative regulation of metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. got7fsn_ti inhibition of organismal metabolic process|downregulation of metabolic process|negative regulation of metabolism|down-regulation of metabolic process|negative regulation of multicellular organismal metabolic process|inhibition of metabolic process|negative regulation of organismal metabolism|down regulation of metabolic process GO:0044252 biological_process owl:Class
GO:0033654 biolink:NamedThing host cell chloroplast thylakoid membrane Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cellular_component owl:Class
GO:0050506 biolink:NamedThing vomilenine glucosyltransferase activity Catalysis of the reaction: UDP-D-glucose + vomilenine = H(+) + raucaffricine + UDP. got7fsn_ti UDP-glucose:vomilenine 21-O-beta-D-glucosyltransferase activity|UDPG:vomilenine 21beta-D-glucosyltransferase activity|vomilenine-glucosyltransferase activity|UDPG:vomilenine 21-beta-D-glucosyltransferase activity MetaCyc:2.4.1.219-RXN|RHEA:19385|EC:2.4.1.219|KEGG_REACTION:R05882 molecular_function owl:Class
GO:0102658 biolink:NamedThing 2-oxo-5-methylthiopentanoate aminotransferase activity Catalysis of the reaction: 5-methylthio-2-oxopentanoate + a standard alpha amino acid <=> L-homomethionine + a 2-oxo carboxylate. got7fsn_ti MetaCyc:RXN-2205 molecular_function owl:Class
GO:0009768 biolink:NamedThing photosynthesis, light harvesting in photosystem I After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center. got7fsn_ti biological_process owl:Class
GO:0140374 biolink:NamedThing antiviral innate immune response A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. got7fsn_ti pg 2019-10-10T16:41:12Z biological_process owl:Class
GO:0014826 biolink:NamedThing vein smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds. got7fsn_ti biological_process owl:Class
GO:0014829 biolink:NamedThing vascular associated smooth muscle contraction A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion. got7fsn_ti vascular smooth muscle contraction biological_process owl:Class
GO:0070914 biolink:NamedThing UV-damage excision repair A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). got7fsn_ti AER|UV-damaged DNA endonuclease-dependent excision repair|alternative excision repair|UVER|UVDE-dependent excision repair mah 2009-09-10T03:14:06Z biological_process owl:Class
GO:0010192 biolink:NamedThing mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants. got7fsn_ti mucilage synthesis|mucilage anabolism|mucilage formation|mucilage biosynthesis biological_process owl:Class
GO:0052764 biolink:NamedThing exo-oligoalginate lyase activity Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends. got7fsn_ti ai 2011-09-29T04:05:44Z EC:4.2.2.26 molecular_function owl:Class
GO:0072762 biolink:NamedThing cellular response to carbendazim Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus. got7fsn_ti mah 2012-11-09T11:48:11Z biological_process owl:Class
GO:0071407 biolink:NamedThing cellular response to organic cyclic compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. got7fsn_ti cellular response to organic cyclic substance mah 2009-12-14T02:55:58Z biological_process owl:Class
GO:0050641 biolink:NamedThing 6-methylsalicylic acid synthase activity Catalysis of the reaction: acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO(2) + 4 CoA + H(2)O + NADP(+). got7fsn_ti acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)|6-MSAS activity|MSAS activity RHEA:12240|KEGG_REACTION:R07253|EC:2.3.1.165|MetaCyc:2.3.1.165-RXN molecular_function owl:Class
GO:1901160 biolink:NamedThing primary amino compound metabolic process The chemical reactions and pathways involving primary amino compound. got7fsn_ti primary amino compound metabolism bf 2012-07-18T04:44:39Z biological_process owl:Class
GO:0030775 biolink:NamedThing glucuronoxylan 4-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate. got7fsn_ti S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity RHEA:20413|EC:2.1.1.112|MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0002139 biolink:NamedThing stereocilia coupling link A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle. got7fsn_ti hjd 2009-05-06T10:25:38Z cellular_component owl:Class
GO:0021854 biolink:NamedThing hypothalamus development The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state. got7fsn_ti biological_process owl:Class
GO:0032265 biolink:NamedThing XMP salvage Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0032261 biolink:NamedThing purine nucleotide salvage Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0072700 biolink:NamedThing response to bismuth Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus. got7fsn_ti response to bismuth ion mah 2012-04-11T02:56:35Z biological_process owl:Class
GO:0031855 biolink:NamedThing oxytocin receptor binding Binding to an oxytocin receptor. got7fsn_ti oxytocin receptor ligand molecular_function owl:Class
GO:0036404 biolink:NamedThing conversion of ds siRNA to ss siRNA The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA). got7fsn_ti conversion of double-stranded small interfering RNA to single-stranded small interfering RNA bf 2013-08-14T14:24:19Z biological_process owl:Class
GO:0031478 biolink:NamedThing myosin VIII complex A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain. got7fsn_ti cellular_component owl:Class
GO:0046153 biolink:NamedThing ommochrome catabolic process The chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. got7fsn_ti ommochrome breakdown|ommochrome degradation|ommochrome catabolism biological_process owl:Class
GO:0102686 biolink:NamedThing UDP-glucose:trans-zeatin 9-N-glucosyltransferase Catalysis of the reaction: UDP-alpha-D-glucose(2-) + trans-zeatin <=> H+ + 9-(alpha-D-glucosyl)-trans-zeatin + UDP(3-). got7fsn_ti MetaCyc:RXN-4722 molecular_function owl:Class
GO:0090082 biolink:NamedThing positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. got7fsn_ti positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|positive regulation of heart induction by negative regulation of canonical Wnt-activated signaling pathway|positive regulation of heart induction by negative regulation of canonical Wnt receptor signalling pathway tb 2009-10-23T10:58:03Z biological_process owl:Class
GO:0090090 biolink:NamedThing negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. got7fsn_ti negative regulation of Wnt receptor signaling pathway through beta-catenin|negative regulation of catenin import into nucleus|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of canonical Wnt-activated signaling pathway|negative regulation of canonical Wnt receptor signalling pathway|negative regulation of catenin protein nuclear translocation tb 2009-10-30T11:27:17Z GO:0035414 biological_process owl:Class
GO:0042034 biolink:NamedThing peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester. got7fsn_ti peptidyl-lysine esterification RESID:AA0318 biological_process owl:Class
GO:0018350 biolink:NamedThing protein esterification The addition of an ester group to a protein amino acid. got7fsn_ti protein amino acid esterification biological_process owl:Class
GO:0044331 biolink:NamedThing cell-cell adhesion mediated by cadherin The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains. got7fsn_ti jl 2010-08-20T10:24:54Z biological_process owl:Class
GO:0050846 biolink:NamedThing teichuronic acid metabolic process The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria. got7fsn_ti teichuronic acid metabolism biological_process owl:Class
GO:0031367 biolink:NamedThing N-terminal peptidyl-glutamine deamination The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein. got7fsn_ti biological_process owl:Class
GO:0004394 biolink:NamedThing heparan sulfate 2-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate. got7fsn_ti heparan-sulfate 2-O-sulphotransferase activity|heparin 2-sulfotransferase activity|heparin-sulphate 2-sulphotransferase activity Reactome:R-HSA-2076508|EC:2.8.2.- molecular_function owl:Class
GO:0048611 biolink:NamedThing embryonic ectodermal digestive tract development The process, occurring during the embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. got7fsn_ti embryonic ectodermal gut development biological_process owl:Class
GO:0048566 biolink:NamedThing embryonic digestive tract development The process whose specific outcome is the progression of the gut over time, from its formation to the mature structure during embryonic development. The gut is the region of the digestive tract extending from the beginning of the intestines to the anus. got7fsn_ti embryonic digestive tract development biological_process owl:Class
GO:0050002 biolink:NamedThing D-proline reductase (dithiol) activity Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline. got7fsn_ti 5-aminopentanoate:lipoate oxidoreductase (cyclizing) Note that this function was formerly EC:1.4.4.1. MetaCyc:1.21.4.1-RXN|EC:1.21.4.1|RHEA:12737 molecular_function owl:Class
GO:0048504 biolink:NamedThing regulation of timing of animal organ formation Any process that modulates the rate, frequency or extent of animal organ formation at a consistent predetermined time point during development. got7fsn_ti timing of organ biosynthesis|timing of organ formation biological_process owl:Class
GO:0030723 biolink:NamedThing ovarian fusome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions. got7fsn_ti ovarian fusome organisation|ovarian fusome organization and biogenesis biological_process owl:Class
GO:0045336 biolink:NamedThing clathrin-coated phagocytic vesicle A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis. got7fsn_ti clathrin-coated phagosome cellular_component owl:Class
GO:0014909 biolink:NamedThing smooth muscle cell migration The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism. got7fsn_ti biological_process owl:Class
GO:0035329 biolink:NamedThing hippo signaling The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1. got7fsn_ti SWH pathway|hippo signalling cascade|hippo signal transduction|Salvador-Warts-Hippo signaling pathway|hippo signaling pathway|hippo signaling cascade bf 2010-02-26T10:43:33Z biological_process owl:Class
GO:0086055 biolink:NamedThing Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. got7fsn_ti dph 2011-11-17T10:51:59Z biological_process owl:Class
GO:0086068 biolink:NamedThing Purkinje myocyte to ventricular cardiac muscle cell communication The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti dph 2011-11-22T09:14:49Z biological_process owl:Class
GO:0050227 biolink:NamedThing pteridine oxidase activity Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown. got7fsn_ti 2-amino-4-hydroxypteridine:oxygen oxidoreductase (7-hydroxylating) EC:1.17.3.1|MetaCyc:PTERIDINE-OXIDASE-RXN|RHEA:12777 molecular_function owl:Class
GO:0046267 biolink:NamedThing triethanolamine catabolic process The chemical reactions and pathways resulting in the breakdown of triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. got7fsn_ti triethanolamine degradation|triethanolamine catabolism|triethanolamine breakdown biological_process owl:Class
GO:0050179 biolink:NamedThing phenylserine aldolase activity Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine. got7fsn_ti L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming)|L-threo-3-phenylserine benzaldehyde-lyase activity KEGG_REACTION:R01766|RHEA:21712|MetaCyc:PHENYLSERINE-ALDOLASE-RXN|EC:4.1.2.26 molecular_function owl:Class
GO:0004869 biolink:NamedThing cysteine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. got7fsn_ti cysteine protease inhibitor activity|thiol protease inhibitor|cystatin GO:0004870 molecular_function owl:Class
GO:0106227 biolink:NamedThing peptidyl-lysine glutarylation The glutarylation of a lysine residue in a protein. got7fsn_ti hjd 2019-10-17T18:57:19Z biological_process owl:Class
GO:0044067 biolink:NamedThing modification by symbiont of host intercellular junctions The process in which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells. got7fsn_ti modification of host intercellular junctions by symbiont biological_process owl:Class
GO:0030699 biolink:NamedThing glycine reductase activity Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin. got7fsn_ti acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming) MetaCyc:RXN-7566|EC:1.21.4.2|RHEA:12232|KEGG_REACTION:R07226 molecular_function owl:Class
GO:0007258 biolink:NamedThing JUN phosphorylation The process of introducing a phosphate group into a JUN protein. got7fsn_ti biological_process owl:Class
GO:0002406 biolink:NamedThing antigen sampling by M cells in mucosal-associated lymphoid tissue The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue. got7fsn_ti antigen sampling by M cells in MALT biological_process owl:Class
GO:0002404 biolink:NamedThing antigen sampling in mucosal-associated lymphoid tissue The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue. got7fsn_ti antigen transport in mucosal-associated lymphoid tissue|antigen transport in MALT|antigen sampling in MALT biological_process owl:Class
GO:0034570 biolink:NamedThing hydroxymonomethylisoproturon dimethylaminedehydrogenase activity Catalysis of the reaction: hydroxymonodemethylisoproturon + H2O = formaldehyde + 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-. got7fsn_ti EC:1.5.99.-|UM-BBD_reactionID:r0894 molecular_function owl:Class
GO:0046932 biolink:NamedThing sodium-transporting ATP synthase activity, rotational mechanism Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate + Na+(out) => ATP + H2O + Na+(in), by a rotational mechanism. got7fsn_ti sodium-translocating F-type ATPase activity|sodium-transporting two-sector ATPase activity https://github.com/geneontology/go-ontology/issues/19380|https://github.com/geneontology/go-ontology/issues/21796 RHEA:58158|RHEA:58156|EC:7.2.2.1|TC:3.A.2.1.2|MetaCyc:3.6.3.15-RXN molecular_function owl:Class
GO:0015081 biolink:NamedThing sodium ion transmembrane transporter activity Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. got7fsn_ti sodium transporter activity GO:0022816 molecular_function owl:Class
GO:0097354 biolink:NamedThing prenylation The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added. got7fsn_ti pr 2012-07-03T01:12:19Z biological_process owl:Class
GO:0008458 biolink:NamedThing carnitine O-octanoyltransferase activity Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA. got7fsn_ti carnitine medium-chain acyltransferase activity|octanoyl-CoA:L-carnitine O-octanoyltransferase activity|overt mitochondrial carnitine palmitoyltransferase|medium-chain/long-chain carnitine acyltransferase activity|easily solubilized mitochondrial carnitine palmitoyltransferase RHEA:17177|Reactome:R-HSA-390281|KEGG_REACTION:R03779|EC:2.3.1.137|MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN molecular_function owl:Class
GO:0016406 biolink:NamedThing carnitine O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule. got7fsn_ti molecular_function owl:Class
GO:1904667 biolink:NamedThing negative regulation of ubiquitin protein ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity. got7fsn_ti negative regulation of APC-Cdc20 complex activity|down-regulation of protein ubiquitination activity|negative regulation of APC/C activity during mitotic cell cycle|downregulation of protein ubiquitination activity|down regulation of ubiquitin protein ligase activity|inhibition of ubiquitin protein ligase activity|negative regulation of E3|downregulation of ubiquitin protein ligase activity|down-regulation of E3|inhibition of E3|negative regulation of mitotic anaphase-promoting complex activity|negative regulation of protein ubiquitination activity|negative regulation of cyclosome activity during mitotic cell cycle|downregulation of E3|down regulation of ubiquitin ligase activity|down regulation of protein ubiquitination activity|down-regulation of ubiquitin protein ligase activity|negative regulation of ubiquitin ligase activity|down-regulation of ubiquitin ligase activity|negative regulation of APC activity during mitotic cell cycle|inhibition of protein ubiquitination activity|down regulation of E3|negative regulation of APC-fizzy related complex activity|inhibition of ubiquitin ligase activity|downregulation of ubiquitin ligase activity|negative regulation of anaphase-promoting complex activity during mitotic cell cycle dph 2015-09-08T15:27:05Z GO:1904190|GO:0060564 biological_process owl:Class
GO:0000257 biolink:NamedThing nitrilase activity Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. got7fsn_ti nitrile aminohydrolase activity|benzonitrilase activity|acetonitrilase activity UM-BBD_enzymeID:e0283|MetaCyc:3.5.5.1-RXN|RHEA:21724|KEGG_REACTION:R00540|EC:3.5.5.1 molecular_function owl:Class
GO:0034405 biolink:NamedThing response to fluid shear stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface. got7fsn_ti biological_process owl:Class
GO:0047609 biolink:NamedThing acetylputrescine deacetylase activity Catalysis of the reaction: N-acetylputrescine + H(2)O = acetate + putrescine. got7fsn_ti N-acetylputrescine acetylhydrolase activity EC:3.5.1.62|MetaCyc:ACETYLPUTRESCINE-DEACETYLASE-RXN|KEGG_REACTION:R01156|RHEA:23412 molecular_function owl:Class
GO:0044178 biolink:NamedThing host cell Golgi membrane The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus. got7fsn_ti host Golgi membrane jl 2009-09-04T03:16:14Z cellular_component owl:Class
GO:0003045 biolink:NamedThing regulation of systemic arterial blood pressure by physical factors The regulation of blood pressure mediated by detection of forces within the circulatory system. got7fsn_ti blood pressure regulation by physical factors biological_process owl:Class
GO:0003073 biolink:NamedThing regulation of systemic arterial blood pressure The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. got7fsn_ti biological_process owl:Class
GO:0032254 biolink:NamedThing establishment of secretory granule localization The directed movement of a secretory granule to a specific location. got7fsn_ti establishment of secretory granule localisation biological_process owl:Class
GO:0102894 biolink:NamedThing UDPG:cyclo-DOPA 5-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + leucodopachrome <=> H+ + cyclo-dopa 5-O-glucoside + UDP. got7fsn_ti MetaCyc:RXN-8481 molecular_function owl:Class
GO:0072051 biolink:NamedThing juxtaglomerular apparatus development The process whose specific outcome is the progression of the juxtaglomerular apparatus over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure that lies adjacent to the glomerulus and regulates kidney function. got7fsn_ti mah 2010-01-25T03:52:23Z biological_process owl:Class
GO:0021948 biolink:NamedThing inward migration of deep nuclear neurons The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position. got7fsn_ti biological_process owl:Class
GO:0032477 biolink:NamedThing homodimeric decaprenyl diphosphate synthase complex A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. got7fsn_ti cellular_component owl:Class
GO:0032476 biolink:NamedThing decaprenyl diphosphate synthase complex A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. got7fsn_ti cellular_component owl:Class
GO:0040002 biolink:NamedThing collagen and cuticulin-based cuticle development Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans. got7fsn_ti collagen and cuticulin-based cuticle formation|collagen and cuticulin-based cuticle biosynthetic process|collagen and cuticulin-based cuticle anabolism|collagen and cuticulin-based cuticle synthesis biological_process owl:Class
GO:0042335 biolink:NamedThing cuticle development The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss. got7fsn_ti cuticle formation|cuticle biosynthesis|cuticle anabolism|cuticle biosynthetic process|cuticle synthesis biological_process owl:Class
GO:0050990 biolink:NamedThing N-terminal protein amino acid carbamoylation The carbamoylation of the N-terminal amino acid of proteins. got7fsn_ti N-terminal protein amino acid carbamylation biological_process owl:Class
GO:0048719 biolink:NamedThing epistomal sclerite morphogenesis The process in which the anatomical structures of the epistomal sclerite are generated and organized. got7fsn_ti biological_process owl:Class
GO:0052790 biolink:NamedThing chitooligosaccharide deacetylase activity Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions. got7fsn_ti ai 2011-10-04T03:48:35Z EC:3.5.1.- molecular_function owl:Class
GO:0006121 biolink:NamedThing mitochondrial electron transport, succinate to ubiquinone The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II. got7fsn_ti complex II (succinate to ubiquinone)|oxidative phosphorylation, succinate to ubiquinone|mitochondrial electron transport, succinate to coenzyme Q biological_process owl:Class
GO:0042649 biolink:NamedThing prothylakoid Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light. got7fsn_ti cellular_component owl:Class
GO:0031976 biolink:NamedThing plastid thylakoid Any thylakoid within a plastid. got7fsn_ti cellular_component owl:Class
GO:0070619 biolink:NamedThing Shc-Grb2-Sos complex A protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. got7fsn_ti Shc-Grb2-mSos1 complex, EGF stimulated mah 2009-04-29T04:30:00Z cellular_component owl:Class
GO:0034679 biolink:NamedThing integrin alpha9-beta1 complex An integrin complex that comprises one alpha9 subunit and one beta1 subunit. got7fsn_ti ITGA9-ITGB1 complex|alpha9-beta1 integrin complex cellular_component owl:Class
GO:0031833 biolink:NamedThing type 7 serotonin receptor binding Binding to a type 7 serotonin receptor. got7fsn_ti 5-hydroxytryptamine 7 receptor binding|type 7 serotonin receptor ligand molecular_function owl:Class
GO:0060333 biolink:NamedThing interferon-gamma-mediated signaling pathway A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far. got7fsn_ti type II IFN-mediated signaling pathway|type II interferon-mediated signaling pathway|immune interferon signaling pathway|interferon-gamma-mediated signalling pathway|gamma-interferon-mediated signaling pathway biological_process owl:Class
GO:0019475 biolink:NamedThing L-lysine catabolic process to acetate The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate. got7fsn_ti lysine fermentation|L-lysine breakdown to acetate|L-lysine degradation to acetate MetaCyc:P163-PWY biological_process owl:Class
GO:0047914 biolink:NamedThing gamma-glutamylhistamine synthase activity Catalysis of the reaction: histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + products of ATP breakdown. got7fsn_ti g-glutamylhistamine synthase activity|gamma-glutaminylhistamine synthetase activity|L-glutamate:histamine ligase activity|gamma-GHA synthetase activity EC:6.3.2.18|RHEA:18881|MetaCyc:GAMMA-GLUTAMYLHISTAMINE-SYNTHASE-RXN molecular_function owl:Class
GO:0036482 biolink:NamedThing neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide. got7fsn_ti H2O2-induced neuron intrinsic apoptotic signaling pathway|hydrogen peroxide-induced neuronal apoptosis|neuron intrinsic apoptotic signaling pathway in response to H2O2|hydrogen peroxide-induced neuron apoptosis|neuron apoptosis in response to hydrogen peroxide bf 2014-08-14T13:23:32Z biological_process owl:Class
GO:0036480 biolink:NamedThing neuron intrinsic apoptotic signaling pathway in response to oxidative stress A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered. got7fsn_ti oxidative stress-induced neuron apoptosis|oxidative stress-induced neuronal apoptosis|neuron apoptosis in response to oxidative stress bf 2014-08-14T13:13:44Z biological_process owl:Class
GO:0047194 biolink:NamedThing indoleacetylglucose-inositol O-acyltransferase activity Catalysis of the reaction: 1-O-(indol-3-ylacetyl)-beta-D-glucose + myo-inositol = 1L-1-O-(indol-3-yl)acetyl-myo-inositol + D-glucose. got7fsn_ti 1-O-(indol-3-ylacetyl)-beta-D-glucose:myo-inositol indole-3-ylacetyltransferase activity|indole-3-acetyl-beta-1-D-glucoside:myo-inositol indoleacetyltransferase activity|1-O-(indol-3-yl)acetyl-beta-D-glucose:myo-inositol (indol-3-yl)acetyltransferase activity KEGG_REACTION:R04333|MetaCyc:2.3.1.72-RXN|RHEA:21180|EC:2.3.1.72 molecular_function owl:Class
GO:0003884 biolink:NamedThing D-amino-acid oxidase activity Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide. got7fsn_ti new yellow enzyme|L-amino acid:O2 oxidoreductase activity|D-amino-acid:oxygen oxidoreductase (deaminating) Reactome:R-HSA-389821|MetaCyc:D-AMINO-ACID-OXIDASE-RXN|EC:1.4.3.3|RHEA:21816 molecular_function owl:Class
GO:0097373 biolink:NamedThing MCM core complex A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated. got7fsn_ti MCM4/6/7 complex pr 2012-09-12T10:41:42Z cellular_component owl:Class
GO:1903445 biolink:NamedThing protein transport from ciliary membrane to plasma membrane The directed movement of protein from ciliary membrane to plasma membrane. got7fsn_ti pr 2014-09-18T07:46:10Z biological_process owl:Class
GO:0061794 biolink:NamedThing conidium development The process whose specific outcome is the progression of conidium over time, from its formation to the mature structure. Conidia are non-motile spores produced via mitotic asexual reproduction in higher fungi; they are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. got7fsn_ti dph 2016-09-17T09:53:51Z biological_process owl:Class
GO:0010698 biolink:NamedThing acetyltransferase activator activity Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule. got7fsn_ti acetyltransferase stimulator activity molecular_function owl:Class
GO:0015722 biolink:NamedThing canalicular bile acid transport Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. got7fsn_ti biological_process owl:Class
GO:0035088 biolink:NamedThing establishment or maintenance of apical/basal cell polarity Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components. got7fsn_ti biological_process owl:Class
GO:0050104 biolink:NamedThing L-gulonate 3-dehydrogenase activity Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH. got7fsn_ti L-3-aldonic dehydrogenase activity|L-gulonic acid dehydrogenase activity|L-beta-hydroxyacid dehydrogenase activity|L-gulonate:NAD+ 3-oxidoreductase activity|L-3-aldonate dehydrogenase activity|L-beta-hydroxy-acid-NAD-oxidoreductase activity|L-3-hydroxyacid dehydrogenase activity RHEA:12889|Reactome:R-HSA-5661290|MetaCyc:L-GULONATE-3-DEHYDROGENASE-RXN|KEGG_REACTION:R02640|EC:1.1.1.45 molecular_function owl:Class
GO:0047355 biolink:NamedThing CDP-glycerol glycerophosphotransferase activity Catalysis of the reaction: glycerophosphate(n) + CDP-glycerol = glycerophosphate(n+1) + CMP. got7fsn_ti poly(glycerol phosphate) polymerase activity|CGPTase activity|CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase activity|teichoic-acid synthase activity|CDPglycerol glycerophosphotransferase activity|teichoic acid glycerol transferase activity|glycerophosphate synthetase activity|cytidine diphosphoglycerol glycerophosphotransferase activity MetaCyc:2.7.8.12-RXN|EC:2.7.8.12|RHEA:13565 molecular_function owl:Class
GO:0102937 biolink:NamedThing 16-alpha-hydroxygypsogenate-UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 16-alpha-hydroxygypsogenate = 16-alpha-hydroxygypsogenate-28-beta-D-glucoside + UDP. got7fsn_ti MetaCyc:RXN-9014 molecular_function owl:Class
GO:0072240 biolink:NamedThing metanephric DCT cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the distal convoluted tubule cells of the metanephros as it progresses from its formation to the mature state. got7fsn_ti metanephric distal convoluted tubule cell differentiation mah 2010-03-19T03:24:25Z biological_process owl:Class
GO:0016622 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome. got7fsn_ti EC:1.2.2.- molecular_function owl:Class
GO:0021658 biolink:NamedThing rhombomere 3 morphogenesis The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0036140 biolink:NamedThing peptidyl-asparagine 3-dioxygenase activity Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2. got7fsn_ti bf 2012-03-07T09:27:44Z molecular_function owl:Class
GO:0035529 biolink:NamedThing NADH pyrophosphatase activity Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+. got7fsn_ti NADH diphosphatase activity|NADH pyrophosphohydrolase activity bf 2010-05-05T04:55:10Z EC:3.6.1.9|KEGG_REACTION:R00103|MetaCyc:RXN0-4401|Reactome:R-HSA-6809287 molecular_function owl:Class
GO:0044751 biolink:NamedThing cellular response to human chorionic gonadotropin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus. got7fsn_ti cellular response to human chorionic gonadotrophin stimulus jl 2012-11-20T16:19:45Z biological_process owl:Class
GO:0044752 biolink:NamedThing response to human chorionic gonadotropin Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus. got7fsn_ti response to human chorionic gonadotropin stimulus jl 2012-11-20T16:21:08Z biological_process owl:Class
GO:0009444 biolink:NamedThing pyruvate oxidation The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate. got7fsn_ti Wikipedia:Pyruvate_decarboxylation|MetaCyc:PYRUVOX-PWY biological_process owl:Class
GO:0006090 biolink:NamedThing pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. got7fsn_ti pyruvate metabolism|pyruvate dehydrogenase bypass GO:0006087 MetaCyc:P41-PWY|Wikipedia:Pyruvic_acid biological_process owl:Class
GO:0080047 biolink:NamedThing GDP-L-galactose phosphorylase activity Catalysis of the reaction: GDP-L-galactose + phosphate = L-galactose-1-P + GDP. got7fsn_ti MetaCyc:RXNQT-4141|RHEA:27698|EC:2.7.7.69 molecular_function owl:Class
GO:0030595 biolink:NamedThing leukocyte chemotaxis The movement of a leukocyte in response to an external stimulus. got7fsn_ti leucocyte chemotaxis|immune cell chemotaxis biological_process owl:Class
GO:0071784 biolink:NamedThing endoplasmic reticulum cisternal network assembly The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) cisternal network. The ER cisternal network is the ER part that comprises the membranes with low curvature in cross-section. got7fsn_ti ER cisternal network assembly|endoplasmic reticulum cisternal network formation|ER cisternal network formation mah 2010-09-01T01:50:49Z biological_process owl:Class
GO:0007490 biolink:NamedThing tergite morphogenesis The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment. got7fsn_ti biological_process owl:Class
GO:0014891 biolink:NamedThing striated muscle atrophy A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. got7fsn_ti biological_process owl:Class
GO:0014889 biolink:NamedThing muscle atrophy A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. got7fsn_ti GO:0014889 should only be used for annotation when muscle atrophy is a normal physiological process and not a disease process. Wikipedia:Muscle_atrophy biological_process owl:Class
GO:0008275 biolink:NamedThing gamma-tubulin small complex A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. got7fsn_ti gamma-tubulin small complex, spindle pole body|Tub4 complex|gammaTuSC|gamma-tubulin small complex, mitotic spindle pole body|gamma-tubulin small complex, centrosomal https://github.com/geneontology/go-ontology/issues/20967 GO:0000927|GO:0000928|GO:0061495 cellular_component owl:Class
GO:1990950 biolink:NamedThing metaphase/anaphase transition of meiosis II The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis II. got7fsn_ti second meiotic metaphase/anaphase transition|meiosis II metaphase/anaphase transition mah 2016-04-25T15:28:51Z biological_process owl:Class
GO:0008804 biolink:NamedThing carbamate kinase activity Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate. got7fsn_ti carbamoyl phosphokinase activity|carbamyl phosphokinase activity|ATP:carbamate phosphotransferase activity|CKase activity RHEA:10152|MetaCyc:CARBAMATE-KINASE-RXN|EC:2.7.2.2 molecular_function owl:Class
GO:0050297 biolink:NamedThing stizolobate synthase activity Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde. got7fsn_ti 3,4-dihydroxy-L-phenylalanine:oxygen 4,5-oxidoreductase (recyclizing) EC:1.13.11.29|MetaCyc:STIZOLOBATE-SYNTHASE-RXN|RHEA:21220 molecular_function owl:Class
GO:0070033 biolink:NamedThing synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin II (or orthologs thereof). got7fsn_ti SNARE complex (Vamp2, Snap25, Stx1a, Cplx2)|Vamp2-Snap25-Stx1a-Cplx2 complex cellular_component owl:Class
GO:0044766 biolink:NamedThing multi-organism transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism. got7fsn_ti jl 2012-12-13T16:25:50Z biological_process owl:Class
GO:0052612 biolink:NamedThing adonirubin 3-hydroxylase activity Catalysis of the reaction: adonirubin + a reduced electron acceptor + oxygen = 3S,3'S-astaxanthin + an oxidized electron acceptor + H2O. got7fsn_ti beta-carotene hydroxylase activity|carotene beta-ring hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity MetaCyc:RXN-8187 molecular_function owl:Class
GO:1990514 biolink:NamedThing 5' transitive RNA interference An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA. got7fsn_ti jl 2014-10-09T15:29:31Z biological_process owl:Class
GO:0036453 biolink:NamedThing transitive RNA interference An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence. got7fsn_ti transitive RNAi bf 2013-11-07T11:14:03Z biological_process owl:Class
GO:0017002 biolink:NamedThing activin-activated receptor activity Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. got7fsn_ti activin receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand activin. For binding to other extracellular ligands, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class
GO:0005001 biolink:NamedThing transmembrane receptor protein tyrosine phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. got7fsn_ti molecular_function owl:Class
GO:0019198 biolink:NamedThing transmembrane receptor protein phosphatase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. got7fsn_ti molecular_function owl:Class
GO:0070741 biolink:NamedThing response to interleukin-6 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. got7fsn_ti response to IL-6 mah 2009-06-19T03:39:12Z biological_process owl:Class
GO:0006499 biolink:NamedThing N-terminal protein myristoylation The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein. got7fsn_ti biological_process owl:Class
GO:0006498 biolink:NamedThing N-terminal protein lipidation The covalent attachment of a lipid group to the amino terminus of a protein. got7fsn_ti biological_process owl:Class
GO:0047393 biolink:NamedThing glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity Catalysis of the reaction: glycerol 1,2-cyclic phosphate + H(2)O = glycerol 1-phosphate + H(+). got7fsn_ti rac-glycerol-1,2-cyclic-phosphate 2-glycerophosphohydrolase activity|rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity RHEA:16493|MetaCyc:3.1.4.42-RXN|EC:3.1.4.42|KEGG_REACTION:R02648 molecular_function owl:Class
GO:0031681 biolink:NamedThing G-protein beta-subunit binding Binding to a G-protein beta subunit. got7fsn_ti G-beta protein subunit binding molecular_function owl:Class
GO:1902712 biolink:NamedThing G protein-coupled GABA receptor complex A protein complex which is capable of G protein-coupled GABA receptor activity. In human, it is usually a heterodimer composed of GABA-B receptor subunits 1 and 2. got7fsn_ti G-protein coupled GABA receptor complex An example of this is GABR1 in human (UniProt symbol Q9UBS5) in PMID:18790874. bhm 2014-02-21T09:47:03Z cellular_component owl:Class
GO:0034571 biolink:NamedThing 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity Catalysis of the reaction: 4'-(2-hydroxyisopropyl)phenylurea + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + carbamic acid. got7fsn_ti UM-BBD_reactionID:r0895 molecular_function owl:Class
GO:0102762 biolink:NamedThing eriodictyol 4'-O-methyltransferase activity Catalysis of the reaction: eriodictyol + S-adenosyl-L-methionine <=> H+ + hesperetin(1-) + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-7754 molecular_function owl:Class
GO:0050830 biolink:NamedThing defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. got7fsn_ti defense response to Gram-positive bacteria|defence response to Gram-positive bacteria|defence response to Gram-positive bacterium|Gram-positive antibacterial peptide activity biological_process owl:Class
GO:0042742 biolink:NamedThing defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. got7fsn_ti resistance response to pathogenic bacteria|defence response to bacteria|defense response to bacterium, incompatible interaction|resistance response to pathogenic bacterium|defence response to bacterium|defense response to bacteria|antibacterial peptide activity GO:0009816|GO:0042830 biological_process owl:Class
GO:0071982 biolink:NamedThing maintenance of diapause The dormancy process that results an organism remaining in diapause. Diapause is a neurohormonally mediated, dynamic state of low metabolic activity. Associated characteristics of this form of dormancy include reduced morphogenesis, increased resistance to environmental extremes, and altered or reduced behavioral activity. Full expression develops in a species-specific manner, usually in response to a number of environmental stimuli that precede unfavorable conditions. Once diapause has begun, metabolic activity is suppressed even if conditions favorable for development prevail. Once initiated, only certain stimuli are capable of releasing the organism from this state, and this characteristic is essential in distinguishing diapause from hibernation. got7fsn_ti mah 2010-10-21T04:46:32Z biological_process owl:Class
GO:0004329 biolink:NamedThing formate-tetrahydrofolate ligase activity Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. got7fsn_ti 10-formyltetrahydrofolate synthetase activity|10-formyl-THF synthetase activity|formyltetrahydrofolate synthetase activity|tetrahydrofolate formylase activity|formate:tetrahydrofolate ligase (ADP-forming)|tetrahydrofolic formylase activity MetaCyc:FORMATETHFLIG-RXN|RHEA:20221|Reactome:R-HSA-6801456|Reactome:R-HSA-5696839|Reactome:R-HSA-200711|EC:6.3.4.3 molecular_function owl:Class
GO:0015844 biolink:NamedThing monoamine transport The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti GO:0015873 biological_process owl:Class
GO:0033542 biolink:NamedThing fatty acid beta-oxidation, unsaturated, even number A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti MetaCyc:PWY-5138 biological_process owl:Class
GO:0047358 biolink:NamedThing UDP-glucose-glycoprotein glucose phosphotransferase activity Catalysis of the reaction: glycoprotein D-mannose + UDP-D-glucose = glycoprotein 6-(D-glucose-1-phospho)-D-mannose + UMP. got7fsn_ti UDPglucose:glycoprotein-D-mannose glucosephosphotransferase activity|UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase activity|UDPglucose-glycoprotein glucose phosphotransferase activity|Glc-phosphotransferase activity|uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase activity|UDP-glucose:glycoprotein glucose-1-phosphotransferase activity|GlcPTase activity RHEA:20181|MetaCyc:2.7.8.19-RXN|EC:2.7.8.19 molecular_function owl:Class
GO:0040010 biolink:NamedThing positive regulation of growth rate Any process that increases the rate of growth of all or part of an organism. got7fsn_ti stimulation of growth rate|up-regulation of growth rate|upregulation of growth rate|up regulation of growth rate|activation of growth rate Note that this term and its definition depart from the usual conventions for GO 'regulation' process terms; regulation of rate is not usually distinguished from regulation of extent or frequency, but it makes sense to do so for growth regulation. biological_process owl:Class
GO:0007120 biolink:NamedThing axial cellular bud site selection The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell. got7fsn_ti axial bud site selection|axial budding biological_process owl:Class
GO:0000282 biolink:NamedThing cellular bud site selection The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti bud site selection/establishment of cell polarity Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010). biological_process owl:Class
GO:1903941 biolink:NamedThing negative regulation of respiratory gaseous exchange Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange. got7fsn_ti down-regulation of respiratory gaseous exchange|down regulation of respiratory gaseous exchange|downregulation of respiratory gaseous exchange|inhibition of respiratory gaseous exchange sl 2015-02-17T20:26:24Z biological_process owl:Class
GO:0071768 biolink:NamedThing mycolic acid biosynthetic process The chemical reactions and pathways resulting in the formation of mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain. got7fsn_ti mycolic acid synthesis|mycolic acid formation|mycolic acid anabolism|mycolate biosynthetic process|mycolic acid biosynthesis mah 2010-03-29T04:36:10Z MetaCyc:PWYG-321 biological_process owl:Class
GO:0060741 biolink:NamedThing prostate gland stromal morphogenesis The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland. got7fsn_ti dph 2009-06-16T09:27:01Z biological_process owl:Class
GO:0048894 biolink:NamedThing efferent axon development in a lateral line nerve The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0021955 biolink:NamedThing central nervous system neuron axonogenesis Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells. got7fsn_ti biological_process owl:Class
GO:0008058 biolink:NamedThing ocellus pigment granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus. got7fsn_ti ocellus pigment granule organization and biogenesis|ocellus pigment granule organisation biological_process owl:Class
GO:0048753 biolink:NamedThing pigment granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule. got7fsn_ti pigment granule organisation|pigment granule organization and biogenesis biological_process owl:Class
GO:0031462 biolink:NamedThing Cul2-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. got7fsn_ti EC2S complex|VBC complex|CRL2 complex|cullin-RING ligase 2|SCF2 complex|ECS complex|CDL2 complex|CBC complex cellular_component owl:Class
GO:0050635 biolink:NamedThing acridone synthase activity Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H(+) + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO(2) + 4 CoA + H(2)O. got7fsn_ti malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing) EC:2.3.1.159|KEGG_REACTION:R07250|MetaCyc:2.3.1.159-RXN|RHEA:22224 molecular_function owl:Class
GO:0033532 biolink:NamedThing stachyose biosynthetic process The chemical reactions and pathways resulting in the formation of stachyose, the tetrasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. got7fsn_ti stachyose synthesis|stachyose anabolism|stachyose formation|stachyose biosynthesis MetaCyc:PWY-5337 biological_process owl:Class
GO:0010325 biolink:NamedThing raffinose family oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization). got7fsn_ti raffinose family oligosaccharide biosynthesis biological_process owl:Class
GO:0030011 biolink:NamedThing maintenance of cell polarity The maintenance of established anisotropic intracellular organization or cell growth patterns. got7fsn_ti GO:0030469|GO:0030013 biological_process owl:Class
GO:2001080 biolink:NamedThing chitosan binding Binding to chitosan. got7fsn_ti jl 2011-09-15T01:17:32Z molecular_function owl:Class
GO:0021794 biolink:NamedThing thalamus development The process in which the thalamus changes over time, from its initial formation to its mature state. got7fsn_ti biological_process owl:Class
GO:0006983 biolink:NamedThing ER overload response The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB. got7fsn_ti EOR|EOR-mediated activation of NF-kappaB|ER-overload response|EOR-mediated NF-kappaB activation|endoplasmic reticulum overload response|positive regulation of NF-kappaB transcription factor activity by ER overload response|positive regulation of NF-kappaB transcription factor activity by EOR GO:0006985 biological_process owl:Class
GO:0048162 biolink:NamedThing multi-layer follicle stage The stage in oogenesis when many layers of follicle cells surround the oocyte. There is a yolk nucleus (Balbiani's Body) near the germinal vesicle. got7fsn_ti mammalian oogenesis stage 5 biological_process owl:Class
GO:0010501 biolink:NamedThing RNA secondary structure unwinding The process in which a secondary structure of RNA are broken or 'melted'. got7fsn_ti RNA duplex unwinding biological_process owl:Class
GO:0015275 biolink:NamedThing stretch-activated, cation-selective, calcium channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching. got7fsn_ti molecular_function owl:Class
GO:0008381 biolink:NamedThing mechanosensitive ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress. got7fsn_ti mechanically gated channel activity|mechanically-gated ion channel activity|mechanically-gated channel activity GO:0022833 TC:1.A.23.2.1 molecular_function owl:Class
GO:0004482 biolink:NamedThing mRNA (guanine-N7-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine. got7fsn_ti messenger RNA guanine 7-methyltransferase activity|guanine-7-methyltransferase activity|S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity|messenger ribonucleate guanine 7-methyltransferase activity|S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity Reactome:R-HSA-77090|Reactome:R-HSA-9694737|Reactome:R-HSA-9684016|Reactome:R-HSA-9694476|MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN|Reactome:R-HSA-9684018|Reactome:R-HSA-9694492|Reactome:R-HSA-9684017|EC:2.1.1.56 molecular_function owl:Class
GO:0071735 biolink:NamedThing IgG immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgG1|IgG2b|IgG3|IgG2|IgG2c|IgG4|IgG2a Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0120232 biolink:NamedThing prenyl-FMNH2 biosynthetic process The chemical reactions and pathways resulting in prenyl-FMNH2, an essential cofactor for the decarboxylase enzymes UbiD and Fdc1. got7fsn_ti prenylated FMNH2 anabolism|prenylated FMNH2 synthesis|prenylated FMNH2 biosynthetic process|prenyl-FMNH2 formation|prenylated FMNH2 biosynthesis|prenylated FMNH2 formation|prenyl-FMNH2 anabolism|prenyl-FMNH2 biosynthesis|prenyl-FMNH2 synthesis https://github.com/geneontology/go-ontology/issues/19244 krc 2020-06-30T19:09:11Z biological_process owl:Class
GO:0090562 biolink:NamedThing protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in). got7fsn_ti tb 2014-04-08T14:55:02Z molecular_function owl:Class
GO:0030890 biolink:NamedThing positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation. got7fsn_ti up-regulation of B cell proliferation|positive regulation of B lymphocyte proliferation|upregulation of B cell proliferation|up regulation of B cell proliferation|activation of B cell proliferation|positive regulation of B-cell proliferation|positive regulation of B-lymphocyte proliferation|stimulation of B cell proliferation biological_process owl:Class
GO:0008676 biolink:NamedThing 3-deoxy-8-phosphooctulonate synthase activity Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate. got7fsn_ti phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)|2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity|3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity|2-keto-3-deoxy-8-phosphooctonic synthetase activity|KDOP synthase activity|3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity|3-deoxyoctulosonic 8-phosphate synthetase activity|KDO-8-phosphate synthetase activity|2-dehydro-3-deoxyphosphooctonate aldolase activity|KDO-8-P synthase activity|3-deoxy-D-manno-octulosonate-8-phosphate synthase activity|2-dehydro-3-deoxy-phosphooctonate aldolase activity|phospho-2-keto-3-deoxyoctonate aldolase activity Note that this function was formerly EC:4.1.2.16. EC:2.5.1.55|KEGG_REACTION:R03254|MetaCyc:KDO-8PSYNTH-RXN|RHEA:14053 molecular_function owl:Class
GO:0048855 biolink:NamedThing adenohypophysis morphogenesis The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. got7fsn_ti anterior pituitary morphogenesis|adenophysis morphogenesis|anterior pituitary gland morphogenesis biological_process owl:Class
GO:0051261 biolink:NamedThing protein depolymerization The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein. got7fsn_ti protein polymer catabolic process|protein polymer breakdown|protein polymer catabolism|protein polymer degradation biological_process owl:Class
GO:0042204 biolink:NamedThing s-triazine compound catabolic process The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. got7fsn_ti s-triazine compound degradation|s-triazine compound catabolism|s-triazine compound breakdown UM-BBD_pathwayID:tria biological_process owl:Class
GO:0004109 biolink:NamedThing coproporphyrinogen oxidase activity Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX. got7fsn_ti coproporphyrinogenase activity|coprogen oxidase activity|coproporphyrinogen:oxygen oxidoreductase (decarboxylating)|coproporphyrinogen-III oxidase activity RHEA:18257|Reactome:R-HSA-189421|MetaCyc:RXN0-1461|KEGG_REACTION:R03220|EC:1.3.3.3 molecular_function owl:Class
GO:0002127 biolink:NamedThing tRNA wobble base cytosine methylation The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position. got7fsn_ti wobble position m5C biosynthesis biological_process owl:Class
GO:0033076 biolink:NamedThing isoquinoline alkaloid metabolic process The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. got7fsn_ti isoquinoline alkaloid metabolism|ipecac alkaloid metabolism biological_process owl:Class
GO:0038150 biolink:NamedThing C-C chemokine receptor CCR2 signaling pathway A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti C-C chemokine receptor type 2 signaling pathway bf 2012-05-11T11:41:02Z biological_process owl:Class
GO:0044293 biolink:NamedThing dendriole Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC). got7fsn_ti jl 2010-02-04T03:32:02Z NIF_Subcellular:sao295057932|NIF_Subcellular:sao28175134 cellular_component owl:Class
GO:0044292 biolink:NamedThing dendrite terminus A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole. got7fsn_ti dendrite terminal specialization|terminal specialization of a dendrite|terminal specialization|dendrite terminal jl 2010-02-04T03:14:37Z NIF_Subcellular:sao28175134 cellular_component owl:Class
GO:0008907 biolink:NamedThing integrase activity Catalysis of the integration of one DNA segment into another. got7fsn_ti Reactome:R-HSA-164523 molecular_function owl:Class
GO:0005123 biolink:NamedThing death receptor binding Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). got7fsn_ti EDAR binding|TNFR1 binding|death receptor interacting protein activity|death receptor-associated factor activity|APO binding|death receptor ligand|KILLER binding|NGFR binding|death receptor adaptor protein activity|FAS binding|DR binding|TRAIL binding molecular_function owl:Class
GO:0047690 biolink:NamedThing aspartyltransferase activity Catalysis of the reaction: L-asparagine + H(+) + hydroxylamine = beta-L-aspartylhydroxamate + NH(4)(+). got7fsn_ti beta-aspartyl transferase activity|aspartotransferase activity|L-asparagine:hydroxylamine gamma-aspartyltransferase activity KEGG_REACTION:R01485|RHEA:11252|MetaCyc:ASPARTYLTRANSFERASE-RXN|EC:2.3.2.7 molecular_function owl:Class
GO:0044416 biolink:NamedThing induction by symbiont of host defense response The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host defense response|upregulation by symbiont of host defense response|positive regulation by organism of defense response of other organism involved in symbiotic interaction|induction by organism of defense response of other organism involved in symbiotic interaction|up regulation by symbiont of host defense response|activation by symbiont of host defense response|activation of host defense response|up-regulation by symbiont of host defense response|stimulation by symbiont of host defense response GO:0052509|GO:0052251|GO:0052510 biological_process owl:Class
GO:0002025 biolink:NamedThing norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change. got7fsn_ti noradrenaline-adrenaline vasodilation involved in regulation of blood pressure|vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure|norepinephrine-epinephrine vasodilation during blood pressure regulation biological_process owl:Class
GO:0019438 biolink:NamedThing aromatic compound biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. got7fsn_ti aromatic compound formation|aromatic hydrocarbon biosynthesis|aromatic compound biosynthesis|aromatic compound anabolism|aromatic compound synthesis|aromatic hydrocarbon biosynthetic process biological_process owl:Class
GO:0008583 biolink:NamedThing mystery cell differentiation The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0033014 biolink:NamedThing tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. got7fsn_ti tetrapyrrole biosynthesis|tetrapyrrole anabolism|tetrapyrrole synthesis|tetrapyrrole formation biological_process owl:Class
GO:0009311 biolink:NamedThing oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. got7fsn_ti oligosaccharide metabolism|multicellular organismal oligosaccharide metabolic process GO:0051690 biological_process owl:Class
GO:0010078 biolink:NamedThing maintenance of root meristem identity The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. got7fsn_ti biological_process owl:Class
GO:0102181 biolink:NamedThing 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl-stigmasta-7,24(241)-dien-3beta-ol + NADH + O2 <=> 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD + H2O. got7fsn_ti MetaCyc:RXN-11937|RHEA:59040 molecular_function owl:Class
GO:0046483 biolink:NamedThing heterocycle metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). got7fsn_ti heterocycle metabolism biological_process owl:Class
GO:0031380 biolink:NamedThing nuclear RNA-directed RNA polymerase complex A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain. got7fsn_ti RDRC|Rdr1 complex cellular_component owl:Class
GO:0034224 biolink:NamedThing cellular response to zinc ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions. got7fsn_ti cellular response to zinc starvation|cellular response to zinc ion limitation biological_process owl:Class
GO:0019784 biolink:NamedThing NEDD8-specific protease activity Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates. got7fsn_ti deneddylase activity Reactome:R-HSA-5690808|Reactome:R-HSA-8863723|Reactome:R-HSA-8956040|Reactome:R-HSA-8956045 molecular_function owl:Class
GO:0030694 biolink:NamedThing bacterial-type flagellum basal body, rod The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings. got7fsn_ti flagellar basal body, rod|flagellin-based flagellum basal body, rod cellular_component owl:Class
GO:0033743 biolink:NamedThing peptide-methionine (R)-S-oxide reductase activity Catalysis of the reaction: peptide-L-methionine + H(2)O + thioredoxin disulfide = peptide-L-methionine (R)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. got7fsn_ti PilB|protein-methionine-R-oxide reductase activity|SelR|methionine sulfoxide reductase activity|methionine S-oxide reductase activity|pMRsr|SelX|MsrB|pMSR|selenoprotein R|methionine S-oxide reductase (R-form oxidizing) activity|methionine sulfoxide reductase B activity|peptide-methionine:thioredoxin-disulfide S-oxidoreductase [methionine (R)-S-oxide-forming] activity GO:0000318 Reactome:R-HSA-5676917|RHEA:24164|EC:1.8.4.12|KEGG_REACTION:R07607|MetaCyc:1.8.4.12-RXN molecular_function owl:Class
GO:0036377 biolink:NamedThing arbuscular mycorrhizal association A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil. got7fsn_ti arbuscular mycorrhizal symbiosis|arbuscular mycorrhizae formation|arbuscular mycorrhizas formation bf 2013-05-07T15:07:32Z biological_process owl:Class
GO:0033413 biolink:NamedThing UGU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UGU codon. got7fsn_ti TGT codon-amino acid adaptor activity|cysteine tRNA Note that in the standard genetic code, TGT codes for cysteine. molecular_function owl:Class
GO:0099556 biolink:NamedThing trans-synaptic signaling by carbon monoxide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0099554 biolink:NamedThing trans-synaptic signaling by soluble gas, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0007478 biolink:NamedThing leg disc morphogenesis The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura. got7fsn_ti leg disc metamorphosis biological_process owl:Class
GO:0051056 biolink:NamedThing regulation of small GTPase mediated signal transduction Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. got7fsn_ti regulation of small GTPase-mediated signal transduction biological_process owl:Class
GO:0005958 biolink:NamedThing DNA-dependent protein kinase-DNA ligase 4 complex A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. got7fsn_ti GO:0005959 cellular_component owl:Class
GO:0047645 biolink:NamedThing alkan-1-ol dehydrogenase (acceptor) activity Catalysis of the reaction: primary alcohol + acceptor = aldehyde + reduced acceptor. got7fsn_ti alkan-1-ol:(acceptor) oxidoreductase activity|polyethylene glycol dehydrogenase activity|alkan-1-ol:acceptor oxidoreductase activity EC:1.1.99.20|MetaCyc:ALKAN-1-OL-DEHYDROGENASE-ACCEPTOR-RXN|RHEA:14685 molecular_function owl:Class
GO:0046740 biolink:NamedThing transport of virus in host, cell to cell The transport of a virus between adjacent cells in a multicellular organism. got7fsn_ti spread of virus in host, cell to cell|intercellular virus transport|viral spread within host, cell to cell|spread of virus within host, cell to cell|cell to cell spread of virus within host VZ:1018 biological_process owl:Class
GO:0047867 biolink:NamedThing dimethylmalate dehydrogenase activity Catalysis of the reaction: (R)-3,3-dimethylmalate + NAD(+) = 3-methyl-2-oxobutanoate + CO(2) + NADH. got7fsn_ti beta,beta-dimethylmalate dehydrogenase activity|(R)-3,3-dimethylmalate:NAD+ oxidoreductase (decarboxylating) KEGG_REACTION:R01211|EC:1.1.1.84|RHEA:13321|MetaCyc:DIMETHYLMALATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0046192 biolink:NamedThing anaerobic phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. got7fsn_ti anaerobic phenol-containing compound biosynthesis|anaerobic phenol-containing compound anabolism|anaerobic phenol-containing compound synthesis|anaerobic phenol-containing compound formation biological_process owl:Class
GO:0042215 biolink:NamedThing anaerobic phenol-containing compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. got7fsn_ti anaerobic phenol-containing compound metabolism UM-BBD_pathwayID:phe biological_process owl:Class
GO:0045513 biolink:NamedThing interleukin-27 binding Binding to interleukin-27. got7fsn_ti IL-27 binding molecular_function owl:Class
GO:0035681 biolink:NamedThing toll-like receptor 15 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 15. got7fsn_ti toll-like receptor 15 signalling pathway|TLR15 signaling pathway bf 2011-02-21T02:38:47Z biological_process owl:Class
GO:0106149 biolink:NamedThing indole-3-carbonyl nitrile 4-hydroxylase activity Catalysis of the reaction: indole-3-carbonyl nitrile + NADPH +O2=4-hydroxyindole-3- carbonyl nitrile + NADP(+) + H20. got7fsn_ti hjd 2018-09-10T19:44:15Z RHEA:57864|EC:1.14.14.165 molecular_function owl:Class
GO:0071612 biolink:NamedThing IP-10 production The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CXCL10 production|chemokine (C-C motif) ligand 10 production mah 2010-02-05T04:43:56Z biological_process owl:Class
GO:0031467 biolink:NamedThing Cul7-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein. got7fsn_ti SCF7 complex|cullin-RING ligase 7|CRL7 complex|CDL7 complex cellular_component owl:Class
GO:0050709 biolink:NamedThing negative regulation of protein secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell. got7fsn_ti downregulation of protein secretion|inhibition of protein secretion|down-regulation of protein secretion|down regulation of protein secretion biological_process owl:Class
GO:0098976 biolink:NamedThing excitatory chemical synaptic transmission Synaptic transmission that results in an excitatory postsynaptic potential. got7fsn_ti biological_process owl:Class
GO:0034026 biolink:NamedThing L-amino-acid alpha-ligase activity Catalysis of the reaction: ATP + an L-amino acid + an L-amino acid = ADP + phosphate + L-aminoacyl-L-amino acid. got7fsn_ti YwfE|bacilysin synthetase activity|L-amino acid ligase activity|L-amino acid alpha-ligase activity RHEA:44332|EC:6.3.2.49|MetaCyc:6.3.2.28-RXN molecular_function owl:Class
GO:0038109 biolink:NamedThing Kit signaling pathway A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell. got7fsn_ti SCF signaling pathway|stem cell factor receptor signaling pathway|stem cell factor signaling pathway|Kit signalling pathway bf 2012-03-22T10:09:48Z biological_process owl:Class
GO:0090219 biolink:NamedThing negative regulation of lipid kinase activity Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid. got7fsn_ti tb 2010-01-12T10:18:30Z biological_process owl:Class
GO:0045833 biolink:NamedThing negative regulation of lipid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids. got7fsn_ti down regulation of lipid metabolic process|down-regulation of lipid metabolic process|downregulation of lipid metabolic process|negative regulation of lipid metabolism|inhibition of lipid metabolic process biological_process owl:Class
GO:0009018 biolink:NamedThing sucrose phosphorylase activity Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate. got7fsn_ti disaccharide glucosyltransferase activity|sucrose glucosyltransferase activity|sucrose:phosphate alpha-D-glucosyltransferase activity RHEA:24048|MetaCyc:SUCROSE-PHOSPHORYLASE-RXN|EC:2.4.1.7 molecular_function owl:Class
GO:0050103 biolink:NamedThing dextrin dextranase activity Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1). got7fsn_ti 1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase activity|dextran dextrinase activity|dextrin 6-glucosyltransferase activity EC:2.4.1.2|RHEA:14625|MetaCyc:DEXTRIN-DEXTRANASE-RXN molecular_function owl:Class
GO:0004550 biolink:NamedThing nucleoside diphosphate kinase activity Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. got7fsn_ti nucleotide phosphate kinase activity|nucleoside diphosphate (UDP) kinase activity|uridine diphosphate kinase activity|nucleoside 5'-diphosphate kinase activity|nucleoside diphosphokinase activity|NDK activity|nucleoside 5'-diphosphate phosphotransferase activity|UDP kinase activity|nucleoside-diphosphate kinase activity|ATP:nucleoside-diphosphate phosphotransferase activity Reactome:R-HSA-482804|Reactome:R-HSA-2162096|Reactome:R-HSA-6806877|Reactome:R-HSA-482621|EC:2.7.4.6|Reactome:R-HSA-482619|MetaCyc:NUCLEOSIDE-DIP-KIN-RXN|Reactome:R-HSA-482812 molecular_function owl:Class
GO:0008995 biolink:NamedThing ribonuclease E activity Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. got7fsn_ti MetaCyc:3.1.26.12-RXN molecular_function owl:Class
GO:1990809 biolink:NamedThing endoplasmic reticulum tubular network membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane. got7fsn_ti vw 2015-07-22T16:42:36Z biological_process owl:Class
GO:0061010 biolink:NamedThing gall bladder development The progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile. got7fsn_ti dph 2010-01-22T09:38:44Z biological_process owl:Class
GO:0071418 biolink:NamedThing cellular response to amine stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. got7fsn_ti mah 2009-12-14T04:08:17Z biological_process owl:Class
GO:1902621 biolink:NamedThing actomyosin contractile ring disassembly The disaggregation of an actomyosin contractile ring into its constituent components. got7fsn_ti contractile actomyosin ring disassembly|constriction ring disassembly|CAR disassembly|actomyosin ring disassembly|cytokinetic ring disassembly mah 2014-01-15T09:27:26Z biological_process owl:Class
GO:0006934 biolink:NamedThing substrate-bound cell migration, adhesion receptor recycling The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions. got7fsn_ti biological_process owl:Class
GO:0007603 biolink:NamedThing phototransduction, visible light The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. got7fsn_ti visual transduction|visual cascade biological_process owl:Class
GO:0009584 biolink:NamedThing detection of visible light The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. got7fsn_ti perception of visible light biological_process owl:Class
GO:0060661 biolink:NamedThing submandibular salivary gland formation The developmental process pertaining to the initial formation of a submandibular salivary gland. This process begins with a thickening of the epithelium next to the tongue and ends when a bud linked to the oral surface is formed. got7fsn_ti dph 2009-06-01T08:07:16Z biological_process owl:Class
GO:0021575 biolink:NamedThing hindbrain morphogenesis The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. got7fsn_ti rhombencephalon morphogenesis biological_process owl:Class
GO:0002035 biolink:NamedThing brain renin-angiotensin system The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system. got7fsn_ti biological_process owl:Class
GO:0047000 biolink:NamedThing 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH. got7fsn_ti 2-keto-3-deoxy-D-gluconate dehydrogenase activity|2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity KEGG_REACTION:R01543|MetaCyc:1.1.1.126-RXN|EC:1.1.1.126|RHEA:15109 molecular_function owl:Class
GO:0035101 biolink:NamedThing FACT complex An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer. got7fsn_ti Facilitates chromatin transcription complex https://github.com/geneontology/go-ontology/issues/19572 cellular_component owl:Class
GO:0072666 biolink:NamedThing establishment of protein localization to vacuole The directed movement of a protein to a specific location in a vacuole. got7fsn_ti establishment of protein localisation to vacuole mah 2011-02-14T02:56:29Z biological_process owl:Class
GO:1990648 biolink:NamedThing inositol-4,5,6-triphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate. got7fsn_ti al 2015-02-23T11:10:51Z molecular_function owl:Class
GO:0009372 biolink:NamedThing quorum sensing The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms. got7fsn_ti quorum sensing system|cell-cell signaling involved in quorum sensing|detection of cell density by secreted molecule GO:0060247|GO:0010699 Wikipedia:Quorum_sensing biological_process owl:Class
GO:0086097 biolink:NamedThing phospholipase C-activating angiotensin-activated signaling pathway An angiotensin-mediated signaling pathway where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores. got7fsn_ti phospholipase C-activating angiotensin-mediated signaling pathway|PLC-activating angiotensin receptor signaling pathway|angiotensin-mediated signaling pathway via activation of phospholipase C|Gq-coupled angiotensin receptor signaling pathway|phospholipase C-activating angiotensin receptor signaling pathway bf 2012-06-13T11:28:15Z biological_process owl:Class
GO:0046504 biolink:NamedThing glycerol ether biosynthetic process The chemical reactions and pathways resulting in the formation of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. got7fsn_ti glycerol ether synthesis|glycerol ether anabolism|glycerol ether formation|glycerol ether biosynthesis biological_process owl:Class
GO:0008455 biolink:NamedThing alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R. got7fsn_ti UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity|alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity|uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity|GnTII activity|alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity|N-acetylglucosaminyltransferase II activity|UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity|acetylglucosaminyltransferase II activity EC:2.4.1.143|Reactome:R-HSA-4793955|Reactome:R-HSA-9694656|MetaCyc:2.4.1.143-RXN|RHEA:12941|Reactome:R-HSA-975829 molecular_function owl:Class
GO:0000800 biolink:NamedThing lateral element A proteinaceous core found between sister chromatids during meiotic prophase. got7fsn_ti axial element In species that have a synaptonemal complex, the lateral elements are part of this complex. S.pombe is an example of a species that lacks a (canonical) synaptonemal complex, but still has lateral elements. cellular_component owl:Class
GO:0038019 biolink:NamedThing Wnt receptor recycling The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. got7fsn_ti Frizzled recycling bf 2011-06-23T04:46:11Z biological_process owl:Class
GO:0043260 biolink:NamedThing laminin-11 complex A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains. got7fsn_ti laminin-521 complex cellular_component owl:Class
GO:0150093 biolink:NamedThing amyloid-beta clearance by transcytosis The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier. got7fsn_ti bc 2018-08-16T14:33:47Z biological_process owl:Class
GO:0045056 biolink:NamedThing transcytosis The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. got7fsn_ti Wikipedia:Transcytosis biological_process owl:Class
GO:0043553 biolink:NamedThing negative regulation of phosphatidylinositol 3-kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity. got7fsn_ti down-regulation of phosphatidylinositol 3-kinase activity|inhibition of phosphatidylinositol 3-kinase activity|down regulation of phosphatidylinositol 3-kinase activity|negative regulation of PI3K activity|downregulation of phosphatidylinositol 3-kinase activity|negative regulation of phosphoinositide 3-kinase activity biological_process owl:Class
GO:0002370 biolink:NamedThing natural killer cell cytokine production Any process that contributes to cytokine production by a natural killer cell. got7fsn_ti NK cell cytokine production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0031036 biolink:NamedThing myosin II filament assembly The formation of a bipolar filament composed of myosin II molecules. got7fsn_ti myosin II polymerization biological_process owl:Class
GO:0034787 biolink:NamedThing 1-hydro-1,1a-dihydroxy-9-fluorenone dehydrogenase activity Catalysis of the reaction: 1-hydro-1,1a-dihydroxy-9-fluorenone + H2O = 2,3-dihydroxy-2'-carboxybiphenyl + 3 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1040 molecular_function owl:Class
GO:0000387 biolink:NamedThing spliceosomal snRNP assembly The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome. got7fsn_ti spliceosomal snRNP biogenesis biological_process owl:Class
GO:0010585 biolink:NamedThing glutamine secretion The controlled release of glutamine by a cell. got7fsn_ti biological_process owl:Class
GO:0010226 biolink:NamedThing response to lithium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. got7fsn_ti biological_process owl:Class
GO:0060829 biolink:NamedThing negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin in the anterior end of the neural plate. This regulation sets up a Wnt signaling gradient along the anterior/posterior axis. got7fsn_ti negative regulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern|negative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation|negative regulation of canonical Wnt receptor signalling pathway involved in neural plate anterior/posterior pattern formation|negative regulation of canonical Wnt-activated signaling pathway involved in neural plate anterior/posterior pattern dph 2009-08-11T01:58:33Z biological_process owl:Class
GO:0052682 biolink:NamedThing epi-cedrol synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = epi-cedrol + diphosphate. got7fsn_ti (2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming) activity|epicedrol synthase activity|8-epicedrol synthase activity EC:4.2.3.39|KEGG_REACTION:R09140|RHEA:26115|MetaCyc:RXN-10004 molecular_function owl:Class
GO:0003112 biolink:NamedThing positive regulation of heart rate by neuronal epinephrine The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction. got7fsn_ti positive regulation of heart rate by neuronal adrenaline biological_process owl:Class
GO:0003065 biolink:NamedThing positive regulation of heart rate by epinephrine The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction. got7fsn_ti adrenaline cardiac chronotropy|positive regulation of heart contraction rate by epinephrine|adrenaline regulation of the rate of heart muscle contraction|positive regulation of heart rate by adrenaline|epinephrine cardiac chronotropy biological_process owl:Class
GO:0033219 biolink:NamedThing urea binding Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2. got7fsn_ti molecular_function owl:Class
GO:0047467 biolink:NamedThing 4-hydroxyphenylacetaldehyde-oxime isomerase activity Catalysis of the reaction: (E)-4-hydroxyphenylacetaldehyde oxime = (Z)-4-hydroxyphenylacetaldehyde oxime. got7fsn_ti molecular_function owl:Class
GO:0034227 biolink:NamedThing tRNA thio-modification The addition a sulfur atom to a nucleotide in a tRNA molecule. got7fsn_ti tRNA sulfurtransferase activity|tRNA thiolation MetaCyc:TRNA-S-TRANSFERASE-RXN|EC:2.8.1.4 biological_process owl:Class
GO:0046875 biolink:NamedThing ephrin receptor binding Binding to an ephrin receptor. got7fsn_ti transmembrane ephrin|Eph receptor binding|ephrin|GPI-linked ephrin molecular_function owl:Class
GO:0071819 biolink:NamedThing DUBm complex A protein complex that forms part of SAGA-type complexes SAGA and SLIK, and mediates deubiquitination of histone H2B. In S. cerevisiae, the DUBm consists of the proteins Ubp8p, Sgf11p, Sus1p, and Sgf73p. got7fsn_ti deubiquitinating module|deubiquitination module|SAGA DUBm complex mah 2010-09-07T11:19:28Z cellular_component owl:Class
GO:0015265 biolink:NamedThing urea channel activity Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti Reactome:R-HSA-507873|Reactome:R-HSA-507875 molecular_function owl:Class
GO:0102501 biolink:NamedThing D-fructuronate reductase activity Catalysis of the reaction: D-mannonate + NADP = NADPH + H+ + D-fructuronate. got7fsn_ti MetaCyc:RXN-14368 molecular_function owl:Class
GO:0018679 biolink:NamedThing dibenzothiophene-5,5-dioxide monooxygenase activity Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate. got7fsn_ti EC:1.14.14.-|MetaCyc:RXN-623|UM-BBD_reactionID:r0235 molecular_function owl:Class
GO:0032304 biolink:NamedThing negative regulation of icosanoid secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell. got7fsn_ti inhibition of icosanoid secretion|down-regulation of icosanoid secretion|negative regulation of eicosanoid secretion|downregulation of icosanoid secretion|down regulation of icosanoid secretion biological_process owl:Class
GO:2000192 biolink:NamedThing negative regulation of fatty acid transport Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport. got7fsn_ti rl 2010-10-18T10:37:15Z biological_process owl:Class
GO:0140381 biolink:NamedThing 4-hydroxytryptamine 4-phosphate methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine (SAM) + 4-hydroxytryptamine 4-phosphate (norbaeocystin) <=> 2 S-adenosyl-L-homocysteine + psilocybin. got7fsn_ti norbaeocystin methyltransferase|psilocybin synthase pg 2019-11-20T10:16:28Z RHEA:55568|EC:2.1.1.345 molecular_function owl:Class
GO:0007517 biolink:NamedThing muscle organ development The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. got7fsn_ti biological_process owl:Class
GO:0030995 biolink:NamedThing cell septum edging catabolic process The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation. got7fsn_ti hydrolysis of edging of cell septum|cell septum edging hydrolysis|hydrolysis of cell septum edging|septum edging hydrolysis biological_process owl:Class
GO:0071999 biolink:NamedThing extracellular polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures. got7fsn_ti extracellular polysaccharide breakdown|extracellular polysaccharide catabolism|extracellular polysaccharide degradation mah 2010-10-25T05:11:25Z biological_process owl:Class
GO:0018516 biolink:NamedThing 2,4-dichlorobenzoyl-CoA reductase activity Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH. got7fsn_ti 4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating) RHEA:23076|EC:1.21.1.2|UM-BBD_reactionID:r0138|MetaCyc:1.3.1.63-RXN|KEGG_REACTION:R05276 molecular_function owl:Class
GO:0021559 biolink:NamedThing trigeminal nerve development The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. got7fsn_ti cranial nerve 5 development|CN V development|cranial nerve V development biological_process owl:Class
GO:0050910 biolink:NamedThing detection of mechanical stimulus involved in sensory perception of sound The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal. got7fsn_ti detection of sound|perception of sound, sensory detection of mechanical stimulus|perception of sound, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during perception of sound|sensory transduction of sound|hearing, sensory transduction of sound|sensory transduction of mechanical stimulus during perception of sound|perception of sound, detection of mechanical stimulus GO:0055128|GO:0009592 biological_process owl:Class
GO:0050334 biolink:NamedThing thiaminase activity Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+). got7fsn_ti thiaminase II activity RHEA:17509|KEGG_REACTION:R02133|MetaCyc:THIAMINASE-RXN|EC:3.5.99.2 molecular_function owl:Class
GO:0047272 biolink:NamedThing phosphopolyprenol glucosyltransferase activity Catalysis of the reaction: polyprenyl phosphate + UDP-D-glucose = polyprenylphosphate-glucose + UDP. got7fsn_ti UDP-glucose:phosphopolyprenol D-glucosyltransferase activity|UDPglucose:polyprenol monophosphate glucosyltransferase activity|UDPglucose:phosphopolyprenol D-glucosyltransferase activity|uridine diphosphoglucose-polyprenol monophosphate glucosyltransferase activity EC:2.4.1.78|MetaCyc:2.4.1.78-RXN molecular_function owl:Class
GO:0019358 biolink:NamedThing nicotinate nucleotide salvage The generation of nicotinate nucleotide without de novo synthesis. got7fsn_ti nicotinate nucleotide biosynthesis, salvage pathway|nicotinate nucleotide biosynthetic process, salvage pathway MetaCyc:PYRIDNUCSAL-PWY|MetaCyc:PWY-5381 biological_process owl:Class
GO:0070489 biolink:NamedThing T cell aggregation The adhesion of one T cell to one or more other T cells via adhesion molecules. got7fsn_ti T-lymphocyte aggregation|T lymphocyte aggregation|T-cell aggregation biological_process owl:Class
GO:0071593 biolink:NamedThing lymphocyte aggregation The adhesion of one lymphocyte to one or more other lymphocytes via adhesion molecules. got7fsn_ti mah 2010-01-29T01:37:30Z biological_process owl:Class
GO:0072247 biolink:NamedThing metanephric glomerular parietal epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. These cells may also give rise to podocytes. got7fsn_ti metanephric Bowman's capsule cell fate commitment mah 2010-03-19T03:42:27Z biological_process owl:Class
GO:0072315 biolink:NamedThing metanephric glomerular epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. got7fsn_ti mah 2010-04-09T07:03:50Z biological_process owl:Class
GO:0071410 biolink:NamedThing cellular response to cyclopentenone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid. got7fsn_ti mah 2009-12-14T03:09:49Z biological_process owl:Class
GO:2000821 biolink:NamedThing regulation of grooming behavior Any process that modulates the frequency, rate or extent of grooming behavior. got7fsn_ti regulation of grooming behaviour rl 2011-07-14T04:48:12Z biological_process owl:Class
GO:0090706 biolink:NamedThing specification of plant organ position The regionalization process in which information that determines the correct position at which plant organ primordia are formed is generated and perceived resulting in correct positioning of the new plant organ. got7fsn_ti tb 2016-10-05T12:33:21Z biological_process owl:Class
GO:0090435 biolink:NamedThing protein localization to nuclear envelope A process in which a protein is transported to, or maintained at, a location within a nuclear envelope. got7fsn_ti protein localization in nuclear envelope tb 2012-07-30T01:50:41Z biological_process owl:Class
GO:0120048 biolink:NamedThing U6 snRNA (adenine-(43)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(43) in U6 snRNA = S-adenosyl-L-homocysteine + N(6)-methyladenine(43) in U6 snRNA. got7fsn_ti krc 2017-06-02T20:37:40Z molecular_function owl:Class
GO:0106346 biolink:NamedThing snRNA methyltransferase activity Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an snRNA molecule. got7fsn_ti hjd 2020-12-18T15:06:44Z molecular_function owl:Class
GO:0106342 biolink:NamedThing omega-hydroxyceramide biosynthetic process The chemical reactions and pathways resulting in the formation of omega-hydroxyceramide/acylceramide. got7fsn_ti hjd 2020-11-17T17:15:25Z biological_process owl:Class
GO:0046513 biolink:NamedThing ceramide biosynthetic process The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid. got7fsn_ti ceramide biosynthesis|ceramide formation|ceramide anabolism|ceramide synthesis biological_process owl:Class
GO:0047323 biolink:NamedThing [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity Catalysis of the reaction: ATP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) = ADP + 3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphate. got7fsn_ti [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity|branched-chain 2-oxo acid dehydrogenase kinase activity|3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase activity|STK2|branched-chain alpha-ketoacid dehydrogenase kinase activity|BCK|ATP:3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) phosphotransferase activity|BCODH kinase activity|branched-chain keto acid dehydrogenase kinase activity|branched-chain oxo acid dehydrogenase kinase (phosphorylating) activity|BCKD kinase activity RHEA:17301|MetaCyc:2.7.11.4-RXN|Reactome:R-HSA-5693148|EC:2.7.11.4 molecular_function owl:Class
GO:0034546 biolink:NamedThing 2,4-dichloroaniline reductive dehalogenase activity Catalysis of the reaction: 2,4-dichloroaniline + 2 H+ + 2 e- = 4-chloroaniline + HCl. got7fsn_ti EC:1.97.1.-|UM-BBD_reactionID:r0819 molecular_function owl:Class
GO:0106341 biolink:NamedThing omega-hydroxyceramide transacylase activity Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N-[30-(9Z,12Z-octadecadienoyloxy)-triacontanoyl]-sphing-4-enine. got7fsn_ti hjd 2020-11-17T17:12:43Z RHEA:55264 molecular_function owl:Class
GO:0016363 biolink:NamedThing nuclear matrix The dense fibrillar network lying on the inner side of the nuclear membrane. got7fsn_ti nucleoskeleton Wikipedia:Nuclear_matrix cellular_component owl:Class
GO:0060836 biolink:NamedThing lymphatic endothelial cell differentiation The process in which a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels. got7fsn_ti dph 2009-08-11T03:45:20Z biological_process owl:Class
GO:0045446 biolink:NamedThing endothelial cell differentiation The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. got7fsn_ti biological_process owl:Class
GO:0003880 biolink:NamedThing protein C-terminal carboxyl O-methyltransferase activity Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. got7fsn_ti C-terminal protein carboxyl methyltransferase activity molecular_function owl:Class
GO:0072487 biolink:NamedThing MSL complex A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3. got7fsn_ti mah 2010-12-10T10:15:11Z cellular_component owl:Class
GO:0009307 biolink:NamedThing DNA restriction-modification system A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. got7fsn_ti DNA restriction biological_process owl:Class
GO:0031252 biolink:NamedThing cell leading edge The area of a motile cell closest to the direction of movement. got7fsn_ti leading edge of cell|front of cell cellular_component owl:Class
GO:0009609 biolink:NamedThing response to symbiotic bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism. got7fsn_ti response to symbiotic bacteria biological_process owl:Class
GO:0033095 biolink:NamedThing aleurone grain A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes. got7fsn_ti aleurone body cellular_component owl:Class
GO:0046316 biolink:NamedThing gluconokinase activity Catalysis of the reaction: D-gluconate + ATP = 6-phospho-D-gluconate + ADP + 2 H(+). got7fsn_ti ATP:D-gluconate 6-phosphotransferase activity|gluconate kinase activity|gluconokinase (phosphorylating) MetaCyc:GLUCONOKIN-RXN|EC:2.7.1.12|RHEA:19433|KEGG_REACTION:R01737 molecular_function owl:Class
GO:0051265 biolink:NamedThing diolein transacylation activity Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein. got7fsn_ti dioleoylglycerol transacylase activity|acyl-CoA-independent diolein transacylation|DOG transacylation|dioleoylglycerol O-acyltransferase activity molecular_function owl:Class
GO:0016411 biolink:NamedThing acylglycerol O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. got7fsn_ti Reactome:R-HSA-1482647|Reactome:R-HSA-1482654 molecular_function owl:Class
GO:0061560 biolink:NamedThing cranial ganglion formation The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti cranial ganglia formation dph 2013-07-10T09:07:27Z biological_process owl:Class
GO:0061554 biolink:NamedThing ganglion formation The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti ganglia formation dph 2013-07-10T08:51:50Z biological_process owl:Class
GO:0035886 biolink:NamedThing vascular associated smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell. got7fsn_ti VSMC differentiation|vascular associated smooth muscle cell differentiation|vascular smooth muscle cell differentiation bf 2011-06-08T11:23:52Z biological_process owl:Class
GO:0060656 biolink:NamedThing regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling Any process that modulates the rate, frequency, or extent of branching of the mammary gland cord as a result of a signal being created by a mammary fat precursor cell and its subsequent reception and interpretation by a mammary cord epithelial cell. got7fsn_ti regulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling dph 2009-05-29T09:34:31Z biological_process owl:Class
GO:0060762 biolink:NamedThing regulation of branching involved in mammary gland duct morphogenesis Any process that modulates the rate, frequency, or extent of branching involved in mammary gland duct morphogenesis. got7fsn_ti dph 2009-06-22T05:20:33Z biological_process owl:Class
GO:0004529 biolink:NamedThing exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. got7fsn_ti molecular_function owl:Class
GO:0060210 biolink:NamedThing metestrus The estrous cycle phase in which there is subsiding follicular function. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0030575 biolink:NamedThing nuclear body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. got7fsn_ti nuclear body organisation|nuclear body organization and biogenesis biological_process owl:Class
GO:0034998 biolink:NamedThing oligosaccharyltransferase I complex An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes. got7fsn_ti OSTCI cellular_component owl:Class
GO:0008250 biolink:NamedThing oligosaccharyltransferase complex A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected. got7fsn_ti OST complex|oligosaccharyl transferase complex cellular_component owl:Class
GO:0051362 biolink:NamedThing peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species. got7fsn_ti biosynthesis of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via 2-tetrahydropyridinyl-5-imidazolinone glycine See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. RESID:AA0382 biological_process owl:Class
GO:0051268 biolink:NamedThing alpha-keto amide reductase activity Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic. got7fsn_ti molecular_function owl:Class
GO:0140456 biolink:NamedThing initial meiotic spindle pole body separation The release of duplicated meiotic spindle pole bodies (SPBs). got7fsn_ti initial spindle pole body separation involved in meiosis I|meiotic spindle pole body duplication https://github.com/geneontology/go-ontology/issues/17971 pg 2020-04-22T19:07:22Z biological_process owl:Class
GO:0050585 biolink:NamedThing 4-hydroxymandelate synthase activity Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2. got7fsn_ti 4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)|4-hydroxyphenylpyruvate dioxygenase II activity EC:1.13.11.46|RHEA:21376|MetaCyc:1.13.11.46-RXN molecular_function owl:Class
GO:0035997 biolink:NamedThing rhabdomere microvillus membrane The portion of the plasma membrane surrounding a microvillus of a rhabdomere. got7fsn_ti bf 2011-09-01T02:24:20Z cellular_component owl:Class
GO:0031528 biolink:NamedThing microvillus membrane The portion of the plasma membrane surrounding a microvillus. got7fsn_ti cellular_component owl:Class
GO:0071568 biolink:NamedThing UFM1 transferase activity Catalysis of the transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y --> Y-UFM1 + X, where both X-UFM1 and Y-UFM1 are covalent linkages. got7fsn_ti mah 2010-01-20T04:10:11Z molecular_function owl:Class
GO:0003985 biolink:NamedThing acetyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. got7fsn_ti acetyl coenzyme A thiolase activity|2-methylacetoacetyl-CoA thiolase|beta-acetoacetyl coenzyme A thiolase activity|acetyl-CoA:N-acetyltransferase activity|acetoacetyl-CoA thiolase activity|thiolase II|acetyl-CoA:acetyl-CoA C-acetyltransferase activity|3-oxothiolase activity|acetyl-CoA acetyltransferase activity MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN|EC:2.3.1.9|UM-BBD_enzymeID:e0144|Reactome:R-HSA-70844|Reactome:R-HSA-74181|Reactome:R-HSA-8848215|RHEA:21036|Reactome:R-HSA-73916 molecular_function owl:Class
GO:0016453 biolink:NamedThing C-acetyltransferase activity Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0071007 biolink:NamedThing U2-type catalytic step 2 spliceosome A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. got7fsn_ti mammalian U2-type spliceosomal complex C|mammalian U2-type spliceosomal complex C1|GT-AG catalytic step 2 spliceosome|major catalytic step 2 spliceosome|yeast U2-type spliceosomal complex A2-2 mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0038035 biolink:NamedThing G protein-coupled receptor signaling in absence of ligand A series of molecular signals beginning with a consequence of a G protein-coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G protein-coupled receptor is not bound to an agonist. got7fsn_ti G-protein coupled receptor signalling in absence of ligand|basal G-protein coupled receptor signaling|G-protein coupled receptor signaling in absence of agonist|G-protein coupled receptor signaling in absence of ligand This term is intended for use by G protein-coupled receptors which signal at a low-level in the absence of agonist binding. bf 2011-10-26T02:31:37Z biological_process owl:Class
GO:0034616 biolink:NamedThing response to laminar fluid shear stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls. got7fsn_ti biological_process owl:Class
GO:1900734 biolink:NamedThing positive regulation of polyketide biosynthetic process Any process that activates or increases the frequency, rate or extent of polyketide biosynthetic process. got7fsn_ti activation of polyketide anabolism|positive regulation of polyketide anabolism|activation of polyketide biosynthetic process|positive regulation of polyketide biosynthesis|up regulation of polyketide formation|up-regulation of polyketide biosynthesis|up-regulation of polyketide anabolism|positive regulation of polyketide formation|up regulation of polyketide anabolism|up-regulation of polyketide formation|up regulation of polyketide biosynthesis|activation of polyketide biosynthesis|up regulation of polyketide synthesis|up-regulation of polyketide biosynthetic process|upregulation of polyketide formation|up-regulation of polyketide synthesis|positive regulation of polyketide synthesis|upregulation of polyketide biosynthetic process|activation of polyketide synthesis|activation of polyketide formation|upregulation of polyketide biosynthesis|up regulation of polyketide biosynthetic process|upregulation of polyketide anabolism|upregulation of polyketide synthesis di 2012-05-26T01:30:10Z biological_process owl:Class
GO:0031328 biolink:NamedThing positive regulation of cellular biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. got7fsn_ti activation of cellular biosynthetic process|positive regulation of cellular biosynthesis|positive regulation of cellular synthesis|stimulation of cellular biosynthetic process|up regulation of cellular biosynthetic process|up-regulation of cellular biosynthetic process|positive regulation of cellular formation|upregulation of cellular biosynthetic process|positive regulation of cellular anabolism biological_process owl:Class
GO:0060077 biolink:NamedThing inhibitory synapse A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. got7fsn_ti Wikipedia:Inhibitory_postsynaptic_potential cellular_component owl:Class
GO:0071044 biolink:NamedThing histone mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA). got7fsn_ti krc 2009-07-30T09:48:10Z biological_process owl:Class
GO:0008334 biolink:NamedThing histone mRNA metabolic process The chemical reactions and pathways involving an mRNA encoding a histone. got7fsn_ti stem-loop-containing histone mRNA 3'-end processing|histone mRNA metabolism In higher Eukaryotes, histone mRNAs (stem-loop containing) are non-polyadenylated and thus have a different form of 3'-end regulation to other mRNAs. In lower Eukaryotes, the 3'-ends of histone mRNAs are polyadenylated. biological_process owl:Class
GO:0018557 biolink:NamedThing 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0422 molecular_function owl:Class
GO:0019117 biolink:NamedThing dihydroxyfluorene dioxygenase activity Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid. got7fsn_ti EC:1.13.11.- molecular_function owl:Class
GO:0021971 biolink:NamedThing corticospinal neuron axon guidance through the medullary pyramid The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues. got7fsn_ti corticospinal neuron axon pathfinding through the medullary pyramid biological_process owl:Class
GO:0047159 biolink:NamedThing 1-alkenylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-alkenylglycerophosphocholine + acyl-CoA = 1-alkenyl-2-acylglycerophosphocholine + CoA. got7fsn_ti acyl-CoA:1-alkenylglycerophosphocholine O-acyltransferase activity MetaCyc:2.3.1.104-RXN|EC:2.3.1.25|RHEA:10344 molecular_function owl:Class
GO:0050894 biolink:NamedThing determination of affect Any process in which an emotional response is associated with a particular sensory stimulation. got7fsn_ti biological_process owl:Class
GO:0016210 biolink:NamedThing naringenin-chalcone synthase activity Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2. got7fsn_ti malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)|DOCS EC:2.3.1.74|RHEA:11128|MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN molecular_function owl:Class
GO:0090014 biolink:NamedThing leaflet formation The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf. got7fsn_ti tb 2009-07-29T11:05:37Z biological_process owl:Class
GO:0060650 biolink:NamedThing epithelial cell proliferation involved in mammary gland bud elongation The multiplication or reproduction of mammary gland bud epithelial cells, resulting in the elongation of the bud. got7fsn_ti dph 2009-05-29T08:54:54Z biological_process owl:Class
GO:0003961 biolink:NamedThing O-acetylhomoserine aminocarboxypropyltransferase activity Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers. got7fsn_ti L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine|L-methionine anabolism, direct, from O-acetyl-L-homoserine|methionine biosynthetic process, direct, from O-acetyl-L-homoserine|L-methionine formation, direct, from O-acetyl-L-homoserine|O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity|O-acetyl-L-homoserine sulfhydrolase activity|O-acetylhomoserine sulfhydrolase activity|O-acetylhomoserine (thiol)-lyase activity|OAH sulfhydrylase activity|L-methionine synthesis, direct, from O-acetyl-L-homoserine|O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity Note that this function was formerly EC:4.2.99.10. GO:0019282 RHEA:10048|MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN|EC:2.5.1.49 molecular_function owl:Class
GO:0034205 biolink:NamedThing amyloid-beta formation The generation of amyloid-beta by cleavage of the amyloid precursor protein (APP). got7fsn_ti beta-amyloid polypeptide formation from APP|beta-amyloid formation|beta-amyloid polypeptide formation from amyloid precursor protein Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because amyloid-beta can only be formed by the proteolysis of a larger molecule (see term definition). The word 'formation' is therefore used in place of biosynthesis. Also, note that this term refers to the production of the amyloid-beta polypeptide from the amyloid precursor protein (APP), and should be used to annotate e.g. secretases that cleave APP to form amyloid-beta. To annotate gene products involved in the formation of amyloid fibrils, please consider 'amyloid fibril formation' (GO:1990000). biological_process owl:Class
GO:0050435 biolink:NamedThing amyloid-beta metabolic process The chemical reactions and pathways involving amyloid-beta, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP). got7fsn_ti beta-amyloid metabolic process|beta-amyloid metabolism|amyloid-beta metabolism biological_process owl:Class
GO:0071596 biolink:NamedThing ubiquitin-dependent protein catabolic process via the N-end rule pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. got7fsn_ti ubiquitin-dependent protein degradation via the N-end rule pathway|ubiquitin-dependent protein catabolism via the N-end rule pathway|ubiquitin-dependent protein breakdown via the N-end rule pathway mah 2010-01-29T03:01:09Z biological_process owl:Class
GO:0051019 biolink:NamedThing mitogen-activated protein kinase binding Binding to a mitogen-activated protein kinase. got7fsn_ti MAPK binding|MAP kinase binding|MAP-kinase anchoring activity molecular_function owl:Class
GO:0120164 biolink:NamedThing conidium germination The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination. got7fsn_ti krc 2018-05-17T17:03:32Z biological_process owl:Class
GO:0060613 biolink:NamedThing fat pad development The progression of a fat pad from its initial formation to its mature structure. A fat pad is an accumulation of adipose tissue. got7fsn_ti dph 2009-05-15T12:42:08Z biological_process owl:Class
GO:0004813 biolink:NamedThing alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). got7fsn_ti L-alanine:tRNAAla ligase (AMP-forming)|alanine-transfer RNA ligase activity|alanyl-transfer RNA synthetase activity|alanine translase activity|Ala-tRNA synthetase activity|alanyl-transfer ribonucleate synthetase activity|alanyl-tRNA synthetase activity|alanyl-transfer ribonucleic acid synthetase activity|AlaRS|alanine tRNA synthetase activity|alanine transfer RNA synthetase activity|alanyl-transfer ribonucleate synthase activity RHEA:12540|EC:6.1.1.7|MetaCyc:ALANINE--TRNA-LIGASE-RXN|Reactome:R-HSA-379864|Reactome:R-HSA-380177 molecular_function owl:Class
GO:0102253 biolink:NamedThing neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity Catalysis of the reaction: neoagarobiose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + beta-D-galactoside. got7fsn_ti EC:3.2.1.159|MetaCyc:RXN-12426 molecular_function owl:Class
GO:0030249 biolink:NamedThing guanylate cyclase regulator activity Modulates the activity of guanylate cyclase. got7fsn_ti molecular_function owl:Class
GO:0007619 biolink:NamedThing courtship behavior The behavior of an organism for the purpose of attracting sexual partners. got7fsn_ti courtship behaviour biological_process owl:Class
GO:0050583 biolink:NamedThing hydrogen dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + H2 = NADPH + H+. got7fsn_ti NADP-reducing hydrogenase activity|NADP-linked hydrogenase activity|hydrogen:NADP+ oxidoreductase activity EC:1.12.1.3|RHEA:18637|MetaCyc:1.12.1.3-RXN molecular_function owl:Class
GO:0016696 biolink:NamedThing oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP. got7fsn_ti EC:1.12.1.- molecular_function owl:Class
GO:0043042 biolink:NamedThing amino acid adenylylation by nonribosomal peptide synthase Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor. got7fsn_ti amino acid adenylation by nonribosomal peptide synthase|amino acid adenylation by NRPS biological_process owl:Class
GO:0050051 biolink:NamedThing leukotriene-B4 20-monooxygenase activity Catalysis of the reaction: leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-hydroxy-leukotriene B4 + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. got7fsn_ti LTB4 omega-hydroxylase activity|LTB(4) 20-hydroxylase activity|LTB(4) omega-hydroxylase activity|leukotriene-B4 omega-hydroxylase activity|leukotriene-B4 20-hydroxylase activity|LTB4 20-hydroxylase activity MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN|RHEA:22176|Reactome:R-HSA-211873|EC:1.14.14.94 molecular_function owl:Class
GO:0001890 biolink:NamedThing placenta development The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. got7fsn_ti placentation|placental development biological_process owl:Class
GO:0019602 biolink:NamedThing toluene oxidation via 3-hydroxytoluene The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol). got7fsn_ti MetaCyc:TOLUENE-DEG-3-OH-PWY biological_process owl:Class
GO:0009384 biolink:NamedThing N-acylmannosamine kinase activity Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. got7fsn_ti acylmannosamine kinase activity|acetylmannosamine kinase activity|ATP:N-acetylmannosamine 6-phosphotransferase activity|acetylamidodeoxymannokinase activity|acylmannosamine kinase (phosphorylating)|ATP:N-acyl-D-mannosamine 6-phosphotransferase activity|N-acetylmannosamine kinase activity|N-acyl-D-mannosamine kinase activity|acylaminodeoxymannokinase activity MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN|EC:2.7.1.60|Reactome:R-HSA-4085028|Reactome:R-HSA-4088322|RHEA:23832 molecular_function owl:Class
GO:0020010 biolink:NamedThing conoid A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules. got7fsn_ti cellular_component owl:Class
GO:0048185 biolink:NamedThing activin binding Binding to activin, a dimer of inhibin-beta subunits. got7fsn_ti molecular_function owl:Class
GO:0006566 biolink:NamedThing threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. got7fsn_ti methionine and threonine metabolic process|threonine metabolism|methionine and threonine metabolism UM-BBD_pathwayID:met biological_process owl:Class
GO:0010490 biolink:NamedThing UDP-4-keto-rhamnose-4-keto-reductase activity Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+. got7fsn_ti molecular_function owl:Class
GO:0021702 biolink:NamedThing cerebellar Purkinje cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. got7fsn_ti biological_process owl:Class
GO:0039522 biolink:NamedThing suppression by virus of host mRNA export from nucleus Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism. got7fsn_ti inhibition by virus of host mRNA nuclear export|negative regulation by virus of host mRNA nuclear export|suppression of host mRNA nuclear export by virus|inhibition of host mRNA nuclear export by virus bf 2011-06-22T04:34:14Z VZ:902 biological_process owl:Class
GO:0050190 biolink:NamedThing phosphoglucokinase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H(+). got7fsn_ti ATP:alpha-D-glucose-1-phosphate 6-phosphotransferase activity|phosphoglucokinase (phosphorylating)|ATP:D-glucose-1-phosphate 6-phosphotransferase activity|glucose-phosphate kinase activity EC:2.7.1.10|KEGG_REACTION:R00949|RHEA:13377|MetaCyc:PHOSPHOGLUCOKINASE-RXN molecular_function owl:Class
GO:0060216 biolink:NamedThing definitive hemopoiesis A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood. got7fsn_ti definitive hematopoiesis|definitive haemopoiesis|definitive haematopoiesis biological_process owl:Class
GO:0102213 biolink:NamedThing in-chain hydroxy fatty acyl-CoA synthetase activity Catalysis of the reaction: coenzyme A + ATP + an in-chain hydroxy fatty acid = diphosphoric acid + AMP + a in-chain hydroxyacyl-CoA. got7fsn_ti MetaCyc:RXN-12184 molecular_function owl:Class
GO:0103107 biolink:NamedThing castasterone 23-O-glucosyltransferase activity Catalysis of the reaction: castasterone + UDP-alpha-D-glucose <=> castasterone-23-O-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXNQT-4398 molecular_function owl:Class
GO:0036221 biolink:NamedThing UTP diphosphatase activity Catalysis of the reaction: UTP + H2O = UMP + diphosphate. got7fsn_ti uridine triphosphate pyrophosphohydrolase activity bf 2012-05-08T01:47:59Z KEGG_REACTION:R00662|RHEA:29395 molecular_function owl:Class
GO:0060802 biolink:NamedThing epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification Any process that mediates the transfer of information from an epiblast cell to an extraembryonic ectoderm cell that contributes to the specification of the anterior/posterior axis. got7fsn_ti epiblast cell-extraembryonic ectoderm cell signalling involved in anterior/posterior axis specification dph 2009-08-06T01:36:13Z biological_process owl:Class
GO:0008841 biolink:NamedThing dihydrofolate synthase activity Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate. got7fsn_ti DHFS activity|H(2)-folate synthetase activity|dihydropteroate:L-glutamate ligase (ADP-forming) activity|FHFS/FPGS activity|dihydrofolate synthetase-folylpolyglutamate synthetase activity|7,8-dihydropteroate:L-glutamate ligase (ADP) activity|FHFS activity|H2-folate synthetase activity|7,8-dihydropteroate:L-glutamate ligase (ADP-forming)|folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity|dihydrofolate synthetase activity|7,8-dihydrofolate synthetase activity RHEA:23584|MetaCyc:DIHYDROFOLATESYNTH-RXN|EC:6.3.2.12 molecular_function owl:Class
GO:0071774 biolink:NamedThing response to fibroblast growth factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fibroblast growth factor stimulus. got7fsn_ti response to fibroblast growth factor stimulus|response to FGF stimulus mah 2010-08-31T11:06:32Z biological_process owl:Class
GO:0097260 biolink:NamedThing eoxin A4 synthase activity Catalysis of the reaction: leukotriene A4 = eoxin A4. got7fsn_ti pr 2012-03-08T02:57:23Z Reactome:R-HSA-2162019 molecular_function owl:Class
GO:0140058 biolink:NamedThing neuron projection arborization The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites. got7fsn_ti neurite branching|branching morphogenesis of a neurite|neuron projection branching|neurite arborization|branching morphogenesis of a neuron projection pg 2017-07-12T12:25:31Z biological_process owl:Class
GO:0045433 biolink:NamedThing male courtship behavior, veined wing generated song production The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song. got7fsn_ti male courtship behavior, song production|male courtship behaviour, song production|male courtship behaviour, veined wing generated song production biological_process owl:Class
GO:0008049 biolink:NamedThing male courtship behavior The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster. got7fsn_ti male courtship behaviour GO:0016542 biological_process owl:Class
GO:0047436 biolink:NamedThing arylmalonate decarboxylase activity Catalysis of the reaction: 2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO(2). got7fsn_ti 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming)|AMDase activity|AMDASE|2-aryl-2-methylmalonate carboxy-lyase activity KEGG_REACTION:R05173|EC:4.1.1.76|RHEA:20513|MetaCyc:4.1.1.76-RXN molecular_function owl:Class
GO:0033580 biolink:NamedThing protein galactosylation at cell surface The addition of a galactose unit to a protein amino acid at the surface of a cell. got7fsn_ti protein amino acid galactosylation at cell surface biological_process owl:Class
GO:0042125 biolink:NamedThing protein galactosylation The addition of a galactose molecule to a protein amino acid. got7fsn_ti protein amino acid galactosylation biological_process owl:Class
GO:0003043 biolink:NamedThing vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. got7fsn_ti vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure biological_process owl:Class
GO:0002012 biolink:NamedThing vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. got7fsn_ti biological_process owl:Class
GO:0032630 biolink:NamedThing interleukin-26 production The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-26 anabolism|interleukin-26 biosynthesis|IL-26 production|AK155 secretion|interleukin-26 biosynthetic process|interleukin-26 synthesis|interleukin-26 secretion|interleukin-26 formation GO:0045526|GO:0072624 biological_process owl:Class
GO:0120298 biolink:NamedThing peptide noradrenalinyltransferase activity Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl-[protein] = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+). got7fsn_ti https://github.com/geneontology/go-ontology/issues/20685 krc 2021-01-19T03:20:26Z RHEA:66560 molecular_function owl:Class
GO:0033572 biolink:NamedThing transferrin transport The directed movement of transferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti melanotransferrin transport biological_process owl:Class
GO:0055058 biolink:NamedThing symmetric neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells. got7fsn_ti biological_process owl:Class
GO:0055057 biolink:NamedThing neuroblast division The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron. got7fsn_ti neuroblast cell division biological_process owl:Class
GO:0008010 biolink:NamedThing structural constituent of chitin-based larval cuticle The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster. got7fsn_ti structural constituent of larval cuticle molecular_function owl:Class
GO:0005214 biolink:NamedThing structural constituent of chitin-based cuticle The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster. got7fsn_ti molecular_function owl:Class
GO:0036066 biolink:NamedThing protein O-linked fucosylation The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage. got7fsn_ti bf 2011-12-15T11:17:20Z biological_process owl:Class
GO:0036065 biolink:NamedThing fucosylation The covalent attachment of a fucosyl group to an acceptor molecule. got7fsn_ti bf 2011-12-15T11:16:19Z biological_process owl:Class
GO:0043991 biolink:NamedThing histone H2B-S14 phosphorylation The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone. got7fsn_ti histone H2BS14 phosphorylation|histone H2B phosphorylation at S14 biological_process owl:Class
GO:0044360 biolink:NamedThing modulation of voltage-gated potassium channel activity in other organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism. got7fsn_ti jl 2011-10-27T02:09:28Z biological_process owl:Class
GO:0052855 biolink:NamedThing ADP-dependent NAD(P)H-hydrate dehydratase activity Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate. got7fsn_ti (6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing; NADH-forming)|(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing)|ADP-dependent H(4)NAD(P)OH dehydratase activity|reduced nicotinamide adenine dinucleotide hydrate dehydratase activity|ADP-dependent H4NAD(P)OH dehydratase activity EC:4.2.1.136 molecular_function owl:Class
GO:0047016 biolink:NamedThing cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity Catalysis of the reaction: NAD+ + 7-alpha-hydroxycholesterol = NADH + H+ + 7-alpha-hydroxycholest-4-en-3-one. got7fsn_ti 3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity|cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase activity|3beta-hydroxy-delta5-C27-steroid oxidoreductase|cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase activity RHEA:11896|EC:1.1.1.181|MetaCyc:1.1.1.181-RXN molecular_function owl:Class
GO:0035668 biolink:NamedThing TRAM-dependent toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. got7fsn_ti TRAM-dependent toll-like receptor signalling pathway|TRAM-dependent TLR signaling pathway bf 2011-02-01T02:39:34Z biological_process owl:Class
GO:0032189 biolink:NamedThing maintenance of actomyosin contractile ring localization Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere. got7fsn_ti cytokinetic ring anchoring|maintenance of contractile ring localization involved in cell cycle cytokinesis|maintenance of contractile ring localisation involved in cell cycle cytokinesis|maintenance of contractile ring localization involved in cytokinesis during cell cycle biological_process owl:Class
GO:0002935 biolink:NamedThing tRNA (adenine-C2-)-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA. got7fsn_ti hjd 2012-09-04T14:39:56Z molecular_function owl:Class
GO:0019266 biolink:NamedThing asparagine biosynthetic process from oxaloacetate The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate. got7fsn_ti asparagine formation from oxaloacetate|asparagine anabolism from oxaloacetate|asparagine synthesis from oxaloacetate MetaCyc:ASPARAGINE-BIOSYNTHESIS biological_process owl:Class
GO:0043649 biolink:NamedThing dicarboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. got7fsn_ti dicarboxylic acid catabolism|dicarboxylic acid breakdown|dicarboxylate catabolism|dicarboxylic acid degradation|dicarboxylate catabolic process biological_process owl:Class
GO:0032880 biolink:NamedThing regulation of protein localization Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. got7fsn_ti regulation of protein localisation biological_process owl:Class
GO:0032608 biolink:NamedThing interferon-beta production The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interferon-beta biosynthetic process|IFNB production|IFN-beta production|interferon-beta secretion Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0045350|GO:0035546 biological_process owl:Class
GO:0106386 biolink:NamedThing (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity Catalysis of the reaction: 3R-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. got7fsn_ti hjd 2021-07-01T18:41:23Z EC:1.1.1.n12|RHEA:32711 molecular_function owl:Class
GO:0008063 biolink:NamedThing Toll signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti Tl signalling pathway|Toll signalling pathway|Tl signaling pathway biological_process owl:Class
GO:0005643 biolink:NamedThing nuclear pore A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. got7fsn_ti nuclear pore complex|nucleopore|nuclear pore membrane protein|NPC GO:0005644 Wikipedia:Nuclear_pore|NIF_Subcellular:sao220861693 cellular_component owl:Class
GO:0009511 biolink:NamedThing plasmodesmatal endoplasmic reticulum Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells. got7fsn_ti plasmodesmatal ER cellular_component owl:Class
GO:0031085 biolink:NamedThing BLOC-3 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins. got7fsn_ti cellular_component owl:Class
GO:0031082 biolink:NamedThing BLOC complex Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex. got7fsn_ti BLOC-1 related complex cellular_component owl:Class
GO:0019931 biolink:NamedThing protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine. got7fsn_ti RESID:AA0312 biological_process owl:Class
GO:0070006 biolink:NamedThing metalloaminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 molecular_function owl:Class
GO:0047955 biolink:NamedThing glycerol dehydrogenase (acceptor) activity Catalysis of the reaction: A + glycerol = AH(2) + glycerone. got7fsn_ti glycerol:(acceptor) 1-oxidoreductase activity|glycerol:acceptor 1-oxidoreductase activity RHEA:17493|EC:1.1.99.22|MetaCyc:GLYCEROL-DEHYDROGENASE-ACCEPTOR-RXN|KEGG_REACTION:R01045 molecular_function owl:Class
GO:0055003 biolink:NamedThing cardiac myofibril assembly The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. got7fsn_ti cardiac myofibril development|heart myofibril assembly|cardiac myofibril morphogenesis biological_process owl:Class
GO:0030239 biolink:NamedThing myofibril assembly Formation of myofibrils, the repeating units of striated muscle. got7fsn_ti biological_process owl:Class
GO:1990191 biolink:NamedThing cobalamin transport complex Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD. got7fsn_ti BtuCDF complex|cobalamin-transporting BtuCDF complex|vitamin B12 transport complex|vitamin B12-transporting BtuCDF complex bhm 2013-09-12T14:20:19Z cellular_component owl:Class
GO:0000293 biolink:NamedThing ferric-chelate reductase activity Catalysis of the reaction: 2 Fe3+-siderophore + electron donor -> 2 Fe3+-siderophore + electron acceptor. got7fsn_ti iron chelate reductase activity|ferric chelate reductase activity https://github.com/geneontology/go-ontology/issues/21029 molecular_function owl:Class
GO:0071609 biolink:NamedThing chemokine (C-C motif) ligand 5 production The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Regulated upon Activation, Normal T-cell Expressed, and Secreted production|CCL5 production|RANTES production mah 2010-02-05T04:32:35Z biological_process owl:Class
GO:1990679 biolink:NamedThing histone H4-K12 deacetylation The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone. got7fsn_ti al 2015-03-02T15:40:44Z biological_process owl:Class
GO:0070933 biolink:NamedThing histone H4 deacetylation The modification of histone H4 by the removal of one or more acetyl groups. got7fsn_ti mah 2009-09-16T04:53:06Z biological_process owl:Class
GO:0072166 biolink:NamedThing posterior mesonephric tubule development The progression of the posterior mesonephric tubule over time, from its initial formation to the mature structure. The posterior mesonephric tubule is an epithelial tube that is part of the mesonephros. got7fsn_ti mah 2010-02-26T01:47:50Z biological_process owl:Class
GO:0030621 biolink:NamedThing U4 snRNA binding Binding to a U4 small nuclear RNA (U4 snRNA). got7fsn_ti molecular_function owl:Class
GO:0090682 biolink:NamedThing GPCR bitter taste receptor activity A G protein-coupled receptor activity that is responsible for the sense of bitter taste. got7fsn_ti G-protein coupled receptor bitter taste receptor activity|G protein-coupled receptor bitter taste receptor activity tb 2016-05-20T15:49:18Z molecular_function owl:Class
GO:0090681 biolink:NamedThing GPCR taste receptor activity A G protein-coupled receptor activity that is responsible for the sense of taste. got7fsn_ti G-protein-coupled taste receptor activity|G-protein coupled taste receptor activity tb 2016-05-20T15:47:18Z molecular_function owl:Class
GO:0047838 biolink:NamedThing D-xylose 1-dehydrogenase (NAD) activity Catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH. got7fsn_ti D-xylose:NAD+ 1-oxidoreductase activity|NAD-D-xylose dehydrogenase activity|NAD-D-xylose|NAD-linked D-xylose dehydrogenase activity|(NAD)-linked D-xylose dehydrogenase activity|D-xylose dehydrogenase activity MetaCyc:D-XYLOSE-1-DEHYDROGENASE-RXN|RHEA:13861|EC:1.1.1.175 molecular_function owl:Class
GO:0071973 biolink:NamedThing bacterial-type flagellum-dependent cell motility Cell motility due to the motion of one or more bacterial-type flagella. A bacterial-type flagellum is a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. got7fsn_ti flagellin-based flagellar cell motility|bacterial-type flagellar cell motility mah 2010-10-21T12:00:53Z biological_process owl:Class
GO:0097588 biolink:NamedThing archaeal or bacterial-type flagellum-dependent cell motility Cell motility due to movement of bacterial- or archaeal-type flagella. got7fsn_ti Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. This term was added for mapping to the UniProt keyword "flagellar rotation". For manual annotation, please use one of the child terms of GO:0097588 that refer specifically to either archaeal- or bacterial-type flagella. pr 2014-03-25T16:51:19Z biological_process owl:Class
GO:0003095 biolink:NamedThing pressure natriuresis The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis). got7fsn_ti biological_process owl:Class
GO:0034669 biolink:NamedThing integrin alpha4-beta7 complex An integrin complex that comprises one alpha4 subunit and one beta7 subunit. got7fsn_ti ITGA4-ITGB7 complex|alpha4-beta7 integrin complex cellular_component owl:Class
GO:0102452 biolink:NamedThing bisdemethoxycurcumin synthase activity Catalysis of the reaction: 2 4-coumaryl-CoA + malonyl-CoA + H2O + H+ <=> 3 coenzyme A + bisdemethoxycurcumin + 2 carbon dioxide. got7fsn_ti RHEA:34803|MetaCyc:RXN-13958|EC:2.3.1.211 molecular_function owl:Class
GO:0021892 biolink:NamedThing cerebral cortex GABAergic interneuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex. got7fsn_ti biological_process owl:Class
GO:0050462 biolink:NamedThing N-acetylneuraminate synthase activity Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate. got7fsn_ti N-acetylneuraminate pyruvate-lyase (pyruvate-phosphorylating) activity|NeuAc synthase activity|N-acetylneuraminic acid synthase activity|(NANA)condensing enzyme activity|phosphoenolpyruvate:N-acetyl-D-mannosamine C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN|EC:2.5.1.56|RHEA:19273 molecular_function owl:Class
GO:0003958 biolink:NamedThing NADPH-hemoprotein reductase activity Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. got7fsn_ti NADPH--cytochrome c reductase activity|cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity|NADPH:P450 reductase activity|dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity|CPR activity|reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity|cytochrome P450 reductase activity|NADPH--cytochrome P450 oxidoreductase activity|NADPH:cytochrome P450 reductase activity|NADPH--ferricytochrome c oxidoreductase activity|reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity|NADPH--ferrihemoprotein reductase activity|ferrihemoprotein P-450 reductase activity|NADPH-dependent cytochrome c reductase activity|POR|NADPH:P-450 reductase activity|TPNH-cytochrome c reductase activity|NADPH:ferrihemoprotein oxidoreductase activity|NADP--cytochrome reductase activity|NADPH--cytochrome c oxidoreductase activity|cytochrome P-450 reductase activity|NADPH-cytochrome P-450 oxidoreductase activity|TPNH(2) cytochrome c reductase activity|NADP--cytochrome c reductase activity|aldehyde reductase (NADPH-dependent) activity|NADPH:cytochrome c reductase activity|NADPH:hemoprotein oxidoreductase activity|NADPH-cytochrome p-450 reductase activity|TPNH2 cytochrome c reductase activity|NADPH-ferrihemoprotein reductase activity|NADPH--cytochrome P450 reductase activity|FAD-cytochrome c reductase activity Reactome:R-HSA-76494|RHEA:24040|MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN|EC:1.6.2.4 molecular_function owl:Class
GO:0052660 biolink:NamedThing R-lactaldehyde reductase activity Catalysis of the reaction: (R)-propane-1,2-diol + NAD+ = (R)-lactaldehyde + NADH + H+. got7fsn_ti D-lactaldehyde:propanediol oxidoreductase activity|(R)-propane-1,2-diol:NAD+ oxidoreductase activity MetaCyc:RXN-8641|RHEA:23872|KEGG_REACTION:R03080 molecular_function owl:Class
GO:0019254 biolink:NamedThing carnitine metabolic process, CoA-linked The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA. got7fsn_ti carnitine metabolism, CoA-linked MetaCyc:CARNMET-PWY biological_process owl:Class
GO:0009437 biolink:NamedThing carnitine metabolic process The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. got7fsn_ti vitamin Bt metabolic process|carnitine metabolism|vitamin Bt metabolism biological_process owl:Class
GO:0035899 biolink:NamedThing negative regulation of blood coagulation in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. got7fsn_ti inhibition of blood coagulation in other organism|suppression of blood coagulation in other organism|downregulation of blood coagulation in other organism|down-regulation of blood coagulation in other organism|negative regulation of blood clotting in other organism bf 2011-06-22T09:17:54Z biological_process owl:Class
GO:0035806 biolink:NamedThing modulation of blood coagulation in other organism Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. got7fsn_ti modulation by organism of blood coagulation in other organism|regulation by organism of blood clotting in other organism|regulation of blood coagulation in other organism|modulation by organism of blood clotting in other organism|regulation of blood clotting in other organism bf 2011-04-20T11:38:49Z biological_process owl:Class
GO:0047348 biolink:NamedThing glycerol-3-phosphate cytidylyltransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + CTP = CDP-glycerol + diphosphate. got7fsn_ti cytidine diphosphoglycerol pyrophosphorylase activity|CDP-glycerol diphosphorylase activity|Gro-PCT|CDP-glycerol pyrophosphorylase activity|cytidine diphosphate glycerol pyrophosphorylase activity|CTP:glycerol-3-phosphate cytidylyltransferase activity|CTP:sn-glycerol-3-phosphate cytidylyltransferase activity|CTP:glycerol 3-phosphate cytidylyltransferase activity MetaCyc:2.7.7.39-RXN|RHEA:13361|KEGG_REACTION:R00856|EC:2.7.7.39 molecular_function owl:Class
GO:0050918 biolink:NamedThing positive chemotaxis The directed movement of a motile cell or organism towards a higher concentration of a chemical. got7fsn_ti chemoattraction biological_process owl:Class
GO:0046543 biolink:NamedThing development of secondary female sexual characteristics The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion. got7fsn_ti biological_process owl:Class
GO:0035503 biolink:NamedThing ureter part of ureteric bud development The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter. got7fsn_ti bf 2010-04-29T03:23:42Z biological_process owl:Class
GO:0090491 biolink:NamedThing N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating) Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O. got7fsn_ti tb 2012-10-16T16:27:19Z molecular_function owl:Class
GO:0018825 biolink:NamedThing triethanolamine lyase activity Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde. got7fsn_ti UM-BBD_enzymeID:e0421 molecular_function owl:Class
GO:0016843 biolink:NamedThing amine-lyase activity Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate. got7fsn_ti EC:4.3.3.- molecular_function owl:Class
GO:0018876 biolink:NamedThing benzonitrile metabolic process The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin. got7fsn_ti benzonitrile metabolism UM-BBD_pathwayID:bzn biological_process owl:Class
GO:0072177 biolink:NamedThing mesonephric duct development The process whose specific outcome is the progression of a mesonephric duct over time, from its initial formation to a mature structure. A mesonephric duct is a tube drains the mesonephros. got7fsn_ti Wolffian duct development mah 2010-02-26T02:32:22Z biological_process owl:Class
GO:0072176 biolink:NamedThing nephric duct development The process whose specific outcome is the progression of a nephric duct over time, from its initial formation to a mature structure. A nephric duct is a tube that drains a primitive kidney. got7fsn_ti mah 2010-02-26T02:27:31Z biological_process owl:Class
GO:0006953 biolink:NamedThing acute-phase response An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. got7fsn_ti biological_process owl:Class
GO:0008770 biolink:NamedThing [acyl-carrier-protein] phosphodiesterase activity Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein. got7fsn_ti holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity|ACP phosphodiesterase activity|ACP hydrolyase activity|[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity|acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity|AcpH|acyl-carrier-protein phosphodiesterase activity|[acyl-carrier protein] phosphodiesterase activity EC:3.1.4.14|MetaCyc:3.1.4.14-RXN|RHEA:20537 molecular_function owl:Class
GO:0036091 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. got7fsn_ti bf 2012-01-10T02:54:43Z biological_process owl:Class
GO:0043619 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to oxidative stress Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. got7fsn_ti biological_process owl:Class
GO:0030952 biolink:NamedThing establishment or maintenance of cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures. got7fsn_ti cytoskeleton polarization biological_process owl:Class
GO:0047969 biolink:NamedThing glyoxylate oxidase activity Catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate. got7fsn_ti glyoxylate:oxygen oxidoreductase activity MetaCyc:GLYOXYLATE-OXIDASE-RXN|RHEA:14837|KEGG_REACTION:R00466|EC:1.2.3.5|Reactome:R-HSA-389862 molecular_function owl:Class
GO:0015193 biolink:NamedThing L-proline transmembrane transporter activity Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. got7fsn_ti proline/glycine/betaine:hydrogen/sodium symporter activity|L-proline permease activity|L-proline transporter activity|glycine betaine/proline porter activity GO:0005296 Reactome:R-HSA-8870354 molecular_function owl:Class
GO:0060410 biolink:NamedThing negative regulation of acetylcholine metabolic process Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. got7fsn_ti biological_process owl:Class
GO:0097233 biolink:NamedThing alveolar lamellar body membrane The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. got7fsn_ti pr 2012-01-26T10:30:24Z cellular_component owl:Class
GO:1990523 biolink:NamedThing bone regeneration The regrowth of bone following its loss or destruction. got7fsn_ti sl 2014-10-30T15:47:39Z biological_process owl:Class
GO:0061326 biolink:NamedThing renal tubule development The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis. got7fsn_ti dph 2010-09-28T12:50:43Z biological_process owl:Class
GO:0050061 biolink:NamedThing long-chain-aldehyde dehydrogenase activity Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons. got7fsn_ti long-chain-aldehyde:NAD+ oxidoreductase activity|long-chain fatty aldehyde dehydrogenase activity|long-chain aliphatic aldehyde dehydrogenase activity|fatty aldehyde:NAD+ oxidoreductase activity EC:1.2.1.48|UM-BBD_reactionID:r1404|RHEA:10652|MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:1990732 biolink:NamedThing pyrenoid A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation. got7fsn_ti pr 2015-04-24T12:44:52Z Wikipedia:Pyrenoid cellular_component owl:Class
GO:0061849 biolink:NamedThing telomeric G-quadruplex DNA binding Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres. got7fsn_ti molecular_function owl:Class
GO:0072064 biolink:NamedThing long descending thin limb development The process whose specific outcome is the progression of the long descending thin limb over time, from its formation to the mature structure. The long descending thin limb is the descending thin limb of a long nephron that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla. got7fsn_ti mah 2010-01-25T04:13:17Z biological_process owl:Class
GO:0072022 biolink:NamedThing descending thin limb development The process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle. got7fsn_ti mah 2010-01-25T02:37:47Z biological_process owl:Class
GO:0071529 biolink:NamedThing cementum mineralization The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum. got7fsn_ti cementum formation mah 2010-01-07T04:18:54Z biological_process owl:Class
GO:0032596 biolink:NamedThing protein transport into membrane raft The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. got7fsn_ti protein translocation into membrane raft|receptor transport into membrane raft|protein transport into lipid raft|receptor translocation into membrane raft biological_process owl:Class
GO:0032594 biolink:NamedThing protein transport within lipid bilayer The directed movement of a protein from one location to another within a lipid bilayer. got7fsn_ti protein translocation within membrane|receptor transport within lipid bilayer|receptor translocation within membrane biological_process owl:Class
GO:0044241 biolink:NamedThing lipid digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class
GO:0007586 biolink:NamedThing digestion The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. got7fsn_ti Wikipedia:Digestion biological_process owl:Class
GO:0070079 biolink:NamedThing histone H4-R3 demethylation The modification of histone H4 by the removal of a methyl group from arginine at position 3 of the histone. got7fsn_ti biological_process owl:Class
GO:0030183 biolink:NamedThing B cell differentiation The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. got7fsn_ti B-cell differentiation|B-lymphocyte differentiation|B lymphocyte differentiation|B cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. GO:0042115 biological_process owl:Class
GO:0044687 biolink:NamedThing geranylfarnesyl diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate. got7fsn_ti jl 2012-08-15T14:20:25Z RHEA:25694|MetaCyc:RXN-8813|EC:2.5.1.81 molecular_function owl:Class
GO:0005221 biolink:NamedThing intracellular cyclic nucleotide activated cation channel activity Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts. got7fsn_ti Reactome:R-HSA-2514867 molecular_function owl:Class
GO:0003431 biolink:NamedThing growth plate cartilage chondrocyte development The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell. got7fsn_ti dph 2009-12-22T12:32:49Z biological_process owl:Class
GO:0003433 biolink:NamedThing chondrocyte development involved in endochondral bone morphogenesis The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone. got7fsn_ti dph 2009-12-22T12:42:44Z biological_process owl:Class
GO:0035643 biolink:NamedThing L-DOPA receptor activity Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine. got7fsn_ti L-dopa receptor activity|L-beta-(3,4-Dihydroxyphenyl)alanine receptor activity bf 2011-01-20T10:34:23Z molecular_function owl:Class
GO:0061231 biolink:NamedThing mesonephric glomerulus vasculature development The biological process whose specific outcome is the progression of a mesonephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the mesonephric glomerulus vasculature and ends with the mature structure. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus. got7fsn_ti dph 2010-08-19T02:47:06Z biological_process owl:Class
GO:0110009 biolink:NamedThing formin-nucleated actin cable organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a formin-nucleated actin cable. got7fsn_ti kmv biological_process owl:Class
GO:0061572 biolink:NamedThing actin filament bundle organization A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle. got7fsn_ti actin filament cable organization dph 2013-08-02T11:24:11Z biological_process owl:Class
GO:0009790 biolink:NamedThing embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. got7fsn_ti embryonal development|embryogenesis and morphogenesis|embryogenesis GO:0009795 Wikipedia:Embryogenesis biological_process owl:Class
GO:0018652 biolink:NamedThing toluene-sulfonate methyl-monooxygenase activity Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol. got7fsn_ti toluene-sulphonate methyl-monooxygenase activity MetaCyc:TSMOS-RXN|UM-BBD_reactionID:r0290|RHEA:51024 molecular_function owl:Class
GO:0004174 biolink:NamedThing electron-transferring-flavoprotein dehydrogenase activity Catalysis of the reaction: a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + H+ + oxidized [electron-transfer flavoprotein]. got7fsn_ti electron transfer flavoprotein Q oxidoreductase activity|electron transfer flavoprotein dehydrogenase activity|electron transfer flavoprotein-ubiquinone oxidoreductase activity|electron-transferring-flavoprotein:ubiquinone oxidoreductase activity|electron transfer flavoprotein reductase activity|ETF:ubiquinone oxidoreductase activity|ETF dehydrogenase activity|ETF-QO activity|ETF-ubiquinone oxidoreductase activity MetaCyc:1.5.5.1-RXN|EC:1.5.5.1|RHEA:24052|Reactome:R-HSA-169270 molecular_function owl:Class
GO:0016649 biolink:NamedThing oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound. got7fsn_ti EC:1.5.5.- molecular_function owl:Class
GO:1990257 biolink:NamedThing piccolo-bassoon transport vesicle A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon. got7fsn_ti PTV pr 2013-12-19T14:12:09Z cellular_component owl:Class
GO:0051383 biolink:NamedThing kinetochore organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. got7fsn_ti kinetochore organization and biogenesis|kinetochore organisation biological_process owl:Class
GO:0002122 biolink:NamedThing fear-induced aggressive behavior Aggressive behavior associated with attempts to flee from a threat. got7fsn_ti fear-induced aggression biological_process owl:Class
GO:0002118 biolink:NamedThing aggressive behavior A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual. got7fsn_ti aggression Wikipedia:Aggression biological_process owl:Class
GO:0140489 biolink:NamedThing molecular template activity The action of a molecule that provides a shape or a sequence mimicking or complementary to the final product, providing template for copying the original molecule's shape or sequence. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19709 pg 2020-07-01T08:42:18Z molecular_function owl:Class
GO:0090064 biolink:NamedThing activation of microtubule nucleation Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. got7fsn_ti tb 2009-08-12T11:36:15Z biological_process owl:Class
GO:0090063 biolink:NamedThing positive regulation of microtubule nucleation Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. got7fsn_ti tb 2009-08-12T11:33:09Z biological_process owl:Class
GO:0048769 biolink:NamedThing sarcomerogenesis The process in which sarcomeres are added in series within a fiber. got7fsn_ti myofibril production biological_process owl:Class
GO:0001661 biolink:NamedThing conditioned taste aversion A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus. got7fsn_ti Wikipedia:Taste_aversion|Wikipedia:Conditioned_taste_aversion biological_process owl:Class
GO:0044265 biolink:NamedThing cellular macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells. got7fsn_ti cellular macromolecule catabolism|cellular macromolecule breakdown|cellular macromolecule degradation|cellular biopolymer catabolic process GO:0034962 biological_process owl:Class
GO:0071084 biolink:NamedThing alpha2-beta1 integrin-CD47 complex A protein complex that consists of an alpha2-beta1 integrin complex bound to the cell surface protein CD47. got7fsn_ti ITGA2-ITGB1-CD47 complex mah 2009-11-06T04:44:35Z cellular_component owl:Class
GO:2001227 biolink:NamedThing quercitrin binding Binding to quercitrin. got7fsn_ti tb 2011-11-18T09:58:37Z molecular_function owl:Class
GO:0038032 biolink:NamedThing termination of G protein-coupled receptor signaling pathway The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal. got7fsn_ti termination of G-protein coupled receptor signaling pathway|termination of G-protein coupled receptor signalling pathway|termination of GPCR signaling pathway bf 2011-09-16T10:31:21Z biological_process owl:Class
GO:0009220 biolink:NamedThing pyrimidine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti pyrimidine ribonucleotide formation|pyrimidine ribonucleotide anabolism|pyrimidine ribonucleotide biosynthesis|pyrimidine ribonucleotide synthesis MetaCyc:PWY0-162 biological_process owl:Class
GO:0070439 biolink:NamedThing Mad-Max-mSin3A complex A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3A, a homolog of the yeast Sin3p. got7fsn_ti cellular_component owl:Class
GO:0038189 biolink:NamedThing neuropilin signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti Npn signaling bf 2013-08-01T16:02:10Z biological_process owl:Class
GO:0110059 biolink:NamedThing negative regulation of blood vessel endothelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation. got7fsn_ti kmv 2017-10-23T14:47:29Z biological_process owl:Class
GO:0045602 biolink:NamedThing negative regulation of endothelial cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation. got7fsn_ti inhibition of endothelial cell differentiation|down-regulation of endothelial cell differentiation|down regulation of endothelial cell differentiation|downregulation of endothelial cell differentiation biological_process owl:Class
GO:0052063 biolink:NamedThing induction by symbiont of defense-related host nitric oxide production The activation by a symbiont of the production of nitric oxide as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti induction by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction|up regulation by symbiont of defense-related host nitric oxide production|activation by organism of defense-related host nitric oxide production|positive regulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction|positive regulation by organism of defense-related host NO production|induction by organism of defense-related host NO production|positive regulation by symbiont of defense-related host nitric oxide production|up-regulation by symbiont of defense-related host nitric oxide production|activation by symbiont of defense-related host nitric oxide production|upregulation by symbiont of defense-related host nitric oxide production|activation by organism of defense-related host NO production|stimulation by symbiont of defense-related host nitric oxide production GO:0052345|GO:0052347|GO:0052263 biological_process owl:Class
GO:0045916 biolink:NamedThing negative regulation of complement activation Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation. got7fsn_ti inhibition of complement activation|downregulation of complement activation|down regulation of complement activation|down-regulation of complement activation|negative regulation of complement cascade biological_process owl:Class
GO:0033653 biolink:NamedThing host cell chloroplast part Any constituent part of a chloroplast as it is found in host cells and which are a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti host chloroplast component Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class
GO:0050525 biolink:NamedThing cutinase activity Catalysis of the reaction: cutin + H2O = cutin monomers. got7fsn_ti cutin hydrolase activity EC:3.1.1.74|MetaCyc:3.1.1.74-RXN molecular_function owl:Class
GO:0060987 biolink:NamedThing lipid tube A macromolecular complex that contains a tube of lipid surrounded by a protein coat. got7fsn_ti dph 2010-01-11T01:54:25Z cellular_component owl:Class
GO:0032994 biolink:NamedThing protein-lipid complex A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other. got7fsn_ti Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes. cellular_component owl:Class
GO:0017050 biolink:NamedThing D-erythro-sphingosine kinase activity Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP. got7fsn_ti sphingosine kinase activity Reactome:R-HSA-9695949|Reactome:R-HSA-428273|RHEA:35847|Reactome:R-HSA-9625814|Reactome:R-HSA-5218845|MetaCyc:RXN3DJ-11417 molecular_function owl:Class
GO:0021715 biolink:NamedThing inferior olivary nucleus formation The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. got7fsn_ti inferior olive biosynthesis|inferior olive formation biological_process owl:Class
GO:0033896 biolink:NamedThing ribonuclease IX activity Catalysis of the endonucleolytic cleavage of poly(U) or poly(C) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. got7fsn_ti poly(U)- and poly(C)-specific endoribonuclease activity MetaCyc:3.1.26.10-RXN|EC:3.1.26.10 molecular_function owl:Class
GO:0035172 biolink:NamedThing hemocyte proliferation The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. got7fsn_ti arthropod blood cell proliferation biological_process owl:Class
GO:2000828 biolink:NamedThing regulation of parathyroid hormone secretion Any process that modulates the frequency, rate or extent of parathyroid hormone secretion. got7fsn_ti regulation of PTH secretion|regulation of parathormone secretion|regulation of parathyrin secretion bf 2011-07-26T08:37:53Z biological_process owl:Class
GO:0008812 biolink:NamedThing choline dehydrogenase activity Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. got7fsn_ti choline:acceptor 1-oxidoreductase activity|choline-cytochrome c reductase activity|choline:(acceptor) 1-oxidoreductase activity|choline:(acceptor) oxidoreductase activity|choline oxidase activity KEGG_REACTION:R01025|EC:1.1.99.1|MetaCyc:CHD-RXN|Reactome:R-HSA-6797961|RHEA:17433 molecular_function owl:Class
GO:0098024 biolink:NamedThing virus tail, fiber The fibrous region of the virus tail used to scan, recognize and attach to the host cell. got7fsn_ti bacteriophage tail fiber For tailed bacteriophages, fibers typically bind to particular Lipopolysaccharide (LPS), polysaccharide or protein receptors on the cell surface. bm 2012-07-19T14:14:50Z cellular_component owl:Class
GO:0034585 biolink:NamedThing 21U-RNA metabolic process The chemical reactions and pathways involving 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. got7fsn_ti 21U-RNA metabolism biological_process owl:Class
GO:0140298 biolink:NamedThing endocytic iron import into cell Uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis. got7fsn_ti iron import into cell by endocytosis pg 2018-12-10T10:31:31Z biological_process owl:Class
GO:0044500 biolink:NamedThing envenomation resulting in negative regulation of blood pressure in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism. got7fsn_ti hypotensive activity in other organism jl 2012-02-01T02:40:50Z biological_process owl:Class
GO:0044498 biolink:NamedThing envenomation resulting in modulation of blood pressure in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism. got7fsn_ti envenomation resulting in regulation of blood pressure in other organism jl 2012-02-01T02:21:27Z biological_process owl:Class
GO:0102721 biolink:NamedThing ubiquinol:oxygen oxidoreductase activity Catalysis of the reaction: O2 + 2 an ubiquinol = 2 H2O + 2 an ubiquinone. got7fsn_ti RHEA:30255|MetaCyc:RXN-6883|EC:1.10.3.11 molecular_function owl:Class
GO:0016682 biolink:NamedThing oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen. got7fsn_ti laccase activity EC:1.10.3.- molecular_function owl:Class
GO:0061389 biolink:NamedThing regulation of direction of cell growth Any process that modulates the direction of cell growth. got7fsn_ti dph 2011-07-14T10:19:46Z biological_process owl:Class
GO:0016890 biolink:NamedThing site-specific endodeoxyribonuclease activity, specific for altered base Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks. got7fsn_ti EC:3.1.25.- molecular_function owl:Class
GO:0050075 biolink:NamedThing maleate hydratase activity Catalysis of the reaction: (R)-malate = H(2)O + maleate. got7fsn_ti malease activity|(R)-malate hydro-lyase activity|D-malate hydro-lyase activity|(R)-malate hydro-lyase (maleate-forming) KEGG_REACTION:R02419|EC:4.2.1.31|RHEA:23692|MetaCyc:MALEATE-HYDRATASE-RXN molecular_function owl:Class
GO:0046804 biolink:NamedThing peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,4Xi,6R)-3-methyl-lanthionine sulfoxide (3-methyl-L-lanthionine sulfoxide), as found in the antibiotic actagardine. got7fsn_ti peptide cross-linking via (2S,3S,4Xi,6R)-3-methyl-lanthionine sulphoxide RESID:AA0330 biological_process owl:Class
GO:0019939 biolink:NamedThing peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically. got7fsn_ti peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine RESID:AA0308 biological_process owl:Class
GO:0045234 biolink:NamedThing protein palmitoleylation The covalent attachment of a palmitoleyl group to a protein. got7fsn_ti protein amino acid palmitoleylation GO:0045235 biological_process owl:Class
GO:0070067 biolink:NamedThing syntaxin-6-syntaxin-16-Vti1a complex A SNARE complex that contains syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof). got7fsn_ti cellular_component owl:Class
GO:0047253 biolink:NamedThing alpha-1,6-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-B-glucosaminyl-1,2)-beta-D-mannosyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-beta-D-(N-acetyl-D-glucosaminyl-1,2-beta)-(N-acetyl-D-glucosaminyl-1,4-beta)-D-mannosyl-R + UDP. got7fsn_ti UDP-N-acetyl-D-glucosamine:2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity|mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI activity|N-acetylglucosaminyltransferase VI activity|uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI|uridine diphosphoacetylglucosamine-glycopeptide beta-1->4-acetylglucosaminyltransferase VI activity|alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity|mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyl-transferase activity EC:2.4.1.201|RHEA:19945|MetaCyc:2.4.1.201-RXN molecular_function owl:Class
GO:0102497 biolink:NamedThing scyllo-inositol dehydrogenase (NADP+) activity Catalysis of the reaction: scyllo-inositol + NADP <=> 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+. got7fsn_ti MetaCyc:RXN-14347|EC:1.1.1.371|RHEA:39063 molecular_function owl:Class
GO:0043006 biolink:NamedThing activation of phospholipase A2 activity by calcium-mediated signaling A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal. got7fsn_ti calcium-dependent phospholipase A2 activation|calcium-dependent activation of phospholipase A2|activation of phospholipase A2 activity by calcium-mediated signalling biological_process owl:Class
GO:0030237 biolink:NamedThing female sex determination The specification of female sex of an individual organism. got7fsn_ti biological_process owl:Class
GO:0033750 biolink:NamedThing ribosome localization A process in which a ribosome is transported to, and/or maintained in, a specific location. got7fsn_ti establishment of ribosome localisation|establishment of ribosome localization|ribosome localisation GO:0033753 biological_process owl:Class
GO:0103092 biolink:NamedThing methylthioalkylmalate isomerase activity Catalysis of the reaction: 2-(7'-methylthio)heptylmalate <=> 3-(7'-methylthio)heptylmalate. got7fsn_ti MetaCyc:RXNQT-4176 molecular_function owl:Class
GO:0031951 biolink:NamedThing positive regulation of glucocorticoid catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. got7fsn_ti stimulation of glucocorticoid catabolic process|up-regulation of glucocorticoid catabolic process|activation of glucocorticoid catabolic process|upregulation of glucocorticoid catabolic process|up regulation of glucocorticoid catabolic process biological_process owl:Class
GO:0021894 biolink:NamedThing cerebral cortex GABAergic interneuron development The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0035451 biolink:NamedThing extrinsic component of stromal side of plastid thylakoid membrane The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to stromal leaflet of plastid thylakoid membrane|peripheral to stromal side of plastid thylakoid membrane|extrinsic to stromal side of plastid thylakoid membrane bf 2010-04-16T10:18:01Z cellular_component owl:Class
GO:0035449 biolink:NamedThing extrinsic component of plastid thylakoid membrane The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti peripheral to plastid thylakoid membrane|extrinsic to plastid thylakoid membrane bf 2010-04-16T10:14:24Z cellular_component owl:Class
GO:0035102 biolink:NamedThing PRC1 complex A multiprotein complex that mediates monoubiquitination of lysine residues of histone H2A (lysine-118 in Drosophila or lysine-119 in mammals). The complex is required for stable long-term maintenance of transcriptionally repressed states and is involved in chromatin remodeling. got7fsn_ti Polycomb repressive complex 1 In Drosophila the core subunits are Pc (Polycomb), Psc (Posterior sex combs), Ph (Polyhomeotic) and Sce (Sex comb extra). In mammals, which have several orthologs for each of the Drosophila core proteins, a family of distinct PRC1-like complexes seem to exist which contain at least some PcG proteins in mutually exclusive manner. cellular_component owl:Class
GO:1990455 biolink:NamedThing PTEN phosphatase complex A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function. got7fsn_ti phosphatase and tensin homolog deleted on chromosome ten homodimer|phosphatase and tensin homolog|phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay). bhm 2014-08-13T10:21:20Z cellular_component owl:Class
GO:0009864 biolink:NamedThing induced systemic resistance, jasmonic acid mediated signaling pathway The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance. got7fsn_ti induced systemic resistance, jasmonic acid mediated signalling pathway|jasmonic acid mediated signaling pathway (induced systemic resistance) biological_process owl:Class
GO:0005741 biolink:NamedThing mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. got7fsn_ti mitochondrion outer membrane|outer mitochondrial membrane|outer mitochondrion membrane Wikipedia:Outer_mitochondrial_membrane|NIF_Subcellular:sao1289741256 cellular_component owl:Class
GO:0031966 biolink:NamedThing mitochondrial membrane Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. got7fsn_ti NIF_Subcellular:sao1045389829 cellular_component owl:Class
GO:0071490 biolink:NamedThing cellular response to far red light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti cellular response to far red light stimulus mah 2009-12-18T02:19:40Z biological_process owl:Class
GO:0097110 biolink:NamedThing scaffold protein binding Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. got7fsn_ti pr 2011-07-28T05:16:53Z molecular_function owl:Class
GO:0048655 biolink:NamedThing anther wall tapetum morphogenesis The process in which the anatomical structures of the anther wall tapetum are generated and organized. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. got7fsn_ti differentiation of tapetal layer|tapetal layer morphogenesis|tapetum morphogenesis biological_process owl:Class
GO:0008286 biolink:NamedThing insulin receptor signaling pathway The series of molecular signals generated as a consequence of the insulin receptor binding to insulin. got7fsn_ti insulin receptor signalling pathway|daf-2 receptor signaling pathway biological_process owl:Class
GO:0039588 biolink:NamedThing suppression by virus of host antigen processing and presentation Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex. got7fsn_ti inhibition of host proteasome antigen processing by virus bf 2012-05-04T04:34:52Z VZ:815 biological_process owl:Class
GO:0002578 biolink:NamedThing negative regulation of antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation. got7fsn_ti downregulation of antigen processing and presentation|inhibition of antigen processing and presentation|down-regulation of antigen processing and presentation|down regulation of antigen processing and presentation biological_process owl:Class
GO:0001081 biolink:NamedThing nitrogen catabolite repression of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. got7fsn_ti negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites krc 2010-10-27T03:38:05Z biological_process owl:Class
GO:0036209 biolink:NamedThing 9beta-pimara-7,15-diene oxidase activity Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]. got7fsn_ti 9-beta-stemod-13(17)-ene oxidase activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.14.13.144. bf 2012-04-25T11:11:55Z GO:0102609 RHEA:31951|MetaCyc:RXN-15437|KEGG_REACTION:R09865|EC:1.14.14.111 molecular_function owl:Class
GO:1990072 biolink:NamedThing TRAPPIII protein complex A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins. got7fsn_ti bhm 2013-03-28T14:28:59Z cellular_component owl:Class
GO:0035003 biolink:NamedThing subapical complex The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells. got7fsn_ti SAC cellular_component owl:Class
GO:0052701 biolink:NamedThing cellular modified histidine metabolic process The chemical reactions and pathways involving compounds derived from histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. got7fsn_ti modified histidine metabolism|cellular histidine derivative metabolic process|histidine derivative metabolic process|modified histidine metabolic process|cellular histidine derivative metabolism|cellular modified histidine metabolism 2011-08-01T03:47:00Z biological_process owl:Class
GO:0046158 biolink:NamedThing ocellus pigment metabolic process The chemical reactions and pathways involving ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. got7fsn_ti ocellus pigment metabolism biological_process owl:Class
GO:1990274 biolink:NamedThing mitotic actomyosin contractile ring disassembly Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle. got7fsn_ti mitotic constriction ring disassembly|mitotic CAR disassembly|mitotic contractile actomyosin ring disassembly|mitotic actomyosin ring disassembly|mitotic cytokinetic ring disassembly mah 2014-01-16T10:25:42Z biological_process owl:Class
GO:0042181 biolink:NamedThing ketone biosynthetic process The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. got7fsn_ti ketone synthesis|ketone anabolism|ketone biosynthesis|ketone formation biological_process owl:Class
GO:0061617 biolink:NamedThing MICOS complex Mitochondrial inner membrane complex involved in maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. In Saccharomyces cerevisiae the complex has six subunits: MIC10, MIC12, MIC19, MIC26, MIC27, and MIC60. got7fsn_ti mitochondrial contact site and cristae organizing system|Fcj1 complex|MINOS complex|MitOS complex dph 2014-04-14T07:18:13Z cellular_component owl:Class
GO:1990522 biolink:NamedThing tail spike morphogenesis The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death. got7fsn_ti jl 2014-10-23T15:20:15Z WBbt:0006979|WBbt:0008072 biological_process owl:Class
GO:0045765 biolink:NamedThing regulation of angiogenesis Any process that modulates the frequency, rate or extent of angiogenesis. got7fsn_ti biological_process owl:Class
GO:0070119 biolink:NamedThing ciliary neurotrophic factor binding Binding to the cytokine ciliary neurotrophic factor. got7fsn_ti CNTF binding molecular_function owl:Class
GO:0021569 biolink:NamedThing rhombomere 3 development The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0103083 biolink:NamedThing methylthiobutylmalate isomerase activity Catalysis of the reaction: 2-(4'-methylthio)butylmalate <=> 3-(4'-methylthio)butylmalate. got7fsn_ti MetaCyc:RXNQT-4167 molecular_function owl:Class
GO:0086044 biolink:NamedThing atrial cardiac muscle cell to AV node cell communication by electrical coupling The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. got7fsn_ti atrial cardiomyocyte to AV node cell communication by electrical coupling|atrial cardiomyocyte to atrioventricular node cell communication by electrical coupling dph 2011-11-15T02:51:29Z biological_process owl:Class
GO:0086066 biolink:NamedThing atrial cardiac muscle cell to AV node cell communication The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti atrial cardiomyocyte to AV node cell communication|atrial cardiomyocyte to atrioventricular node cell communication dph 2011-11-22T09:05:09Z biological_process owl:Class
GO:0018668 biolink:NamedThing 3-hydroxybenzoate 4-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+). got7fsn_ti 3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)|3-hydroxybenzoate 4-hydroxylase activity UM-BBD_reactionID:r0153|MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN|RHEA:11480|KEGG_REACTION:R01628|EC:1.14.13.23 molecular_function owl:Class
GO:0051172 biolink:NamedThing negative regulation of nitrogen compound metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. got7fsn_ti negative regulation of nitrogen metabolism|inhibition of nitrogen metabolic process|negative regulation of nitrogen metabolic process|downregulation of nitrogen metabolic process|down regulation of nitrogen metabolic process|down-regulation of nitrogen metabolic process biological_process owl:Class
GO:0033575 biolink:NamedThing protein glycosylation at cell surface The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid at the surface of a cell. got7fsn_ti protein amino acid glycosylation at cell surface biological_process owl:Class
GO:0021753 biolink:NamedThing superior salivary nucleus development The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0021751 biolink:NamedThing salivary nucleus development The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0031490 biolink:NamedThing chromatin DNA binding Binding to DNA that is assembled into chromatin. got7fsn_ti molecular_function owl:Class
GO:0003682 biolink:NamedThing chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. got7fsn_ti lamin/chromatin binding|microtubule/chromatin interaction|nuclear membrane vesicle binding to chromatin molecular_function owl:Class
GO:0030951 biolink:NamedThing establishment or maintenance of microtubule cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures. got7fsn_ti biological_process owl:Class
GO:0034840 biolink:NamedThing 3-hydroxymenthone dehydrogenase activity Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+. got7fsn_ti UM-BBD_reactionID:r1185 molecular_function owl:Class
GO:0048172 biolink:NamedThing regulation of short-term neuronal synaptic plasticity A process that modulates short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. got7fsn_ti Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:0072145 biolink:NamedThing proximal convoluted tubule segment 1 cell development The process whose specific outcome is the progression of an S1 cell in the kidney over time, from its formation to the mature structure. got7fsn_ti S1 cell development mah 2010-02-24T01:54:56Z biological_process owl:Class
GO:0050371 biolink:NamedThing tyrosine phenol-lyase activity Catalysis of the reaction: L-tyrosine + H(2)O = NH(4)(+) + phenol + pyruvate. got7fsn_ti beta-tyrosinase activity|L-tyrosine phenol-lyase (deaminating)|L-tyrosine phenol-lyase (deaminating; pyruvate-forming) MetaCyc:TYROSINE-PHENOL-LYASE-RXN|EC:4.1.99.2|KEGG_REACTION:R00728|RHEA:21704 molecular_function owl:Class
GO:0052714 biolink:NamedThing mannosyl-inositol phosphorylceramide phospholipase activity Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol. got7fsn_ti ai 2011-08-05T08:02:57Z molecular_function owl:Class
GO:0052713 biolink:NamedThing inositol phosphorylceramide phospholipase activity Catalysis of the reaction: inositol phosphorylceramide + H2O = C26-phytoceramide + phosphorylinositol. got7fsn_ti ai 2011-08-05T04:51:03Z molecular_function owl:Class
GO:0120205 biolink:NamedThing photoreceptor proximal connecting cilium The proximal region of the photoreceptor connecting cilium is similar to the transition zone of unspecialized primary cilia and houses several major transition zone complexes, including NPHP, MKS, and RPGR. got7fsn_ti photoreceptor PCC|PCC krc 2019-05-10T22:47:08Z cellular_component owl:Class
GO:0034543 biolink:NamedThing 5-aminosalicylate dioxygenase activity Catalysis of the reaction: 5-aminosalicylate + O2 = cis-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate. got7fsn_ti UM-BBD_reactionID:r0809|EC:1.13.11.- molecular_function owl:Class
GO:0044596 biolink:NamedThing 3-demethylubiquinol-10 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-10 = S-adenosyl-L-homocysteine + ubiquinol-10. got7fsn_ti jl 2012-04-26T04:54:11Z MetaCyc:RXN-9237|Reactome:R-HSA-2162186|RHEA:44412 molecular_function owl:Class
GO:0071928 biolink:NamedThing tyramine signaling pathway The series of molecular signals generated as a consequence of tyramine binding to a cell surface receptor. got7fsn_ti tyramine signalling pathway mah 2010-09-28T01:20:10Z biological_process owl:Class
GO:0007211 biolink:NamedThing octopamine or tyramine signaling pathway The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters. got7fsn_ti octopamine or tyramine signalling pathway|octopamine/tyramine signaling pathway biological_process owl:Class
GO:0014719 biolink:NamedThing skeletal muscle satellite cell activation The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. got7fsn_ti biological_process owl:Class
GO:0018510 biolink:NamedThing phloroglucinol reductase activity Catalysis of the reaction: dihydrophloroglucinol + NADP(+) = H(+) + NADPH + phloroglucinol. got7fsn_ti dihydrophloroglucinol:NADP+ oxidoreductase activity UM-BBD_reactionID:r0007|RHEA:10080|EC:1.3.1.57|MetaCyc:R5-RXN|KEGG_REACTION:R05308 molecular_function owl:Class
GO:0033451 biolink:NamedThing GUA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GUA codon. got7fsn_ti valine tRNA|GTA codon-amino acid adaptor activity Note that in the standard genetic code, GTA codes for valine. molecular_function owl:Class
GO:0034138 biolink:NamedThing toll-like receptor 3 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 3. got7fsn_ti toll-like receptor 3 signalling pathway|TLR3 signaling pathway biological_process owl:Class
GO:0003195 biolink:NamedThing tricuspid valve formation The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti dph 2009-10-08T01:14:40Z biological_process owl:Class
GO:0009032 biolink:NamedThing thymidine phosphorylase activity Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate. got7fsn_ti thymidine-orthophosphate deoxyribosyltransferase activity|thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity|thymidine:phosphate deoxy-D-ribosyltransferase activity|pyrimidine phosphorylase activity RHEA:16037|EC:2.4.2.4|MetaCyc:THYM-PHOSPH-RXN molecular_function owl:Class
GO:0036230 biolink:NamedThing granulocyte activation The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti bf 2012-05-11T10:57:48Z biological_process owl:Class
GO:0031682 biolink:NamedThing G-protein gamma-subunit binding Binding to a G-protein gamma subunit. got7fsn_ti G-gamma protein subunit binding molecular_function owl:Class
GO:0048718 biolink:NamedThing cibarial fish-trap bristle morphogenesis The process in which the anatomical structures of a cibarial fish-trap bristle are generated and organized. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium. got7fsn_ti fish trap bristle morphogenesis biological_process owl:Class
GO:0010166 biolink:NamedThing wax metabolic process The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids. got7fsn_ti wax metabolism biological_process owl:Class
GO:0072060 biolink:NamedThing outer medullary collecting duct development The process whose specific outcome is the progression of the outer medullary collecting duct over time, from its formation to the mature structure. The outer medullary collecting duct is the portion of the collecting duct that lies in the renal outer medulla. got7fsn_ti mah 2010-01-25T04:08:18Z biological_process owl:Class
GO:0051982 biolink:NamedThing copper-nicotianamine transmembrane transporter activity Enables the transfer of the copper chelate copper-nicotianamine (Cu-NA) from one side of a membrane to the other. got7fsn_ti Cu-NA chelate transporter activity molecular_function owl:Class
GO:0021531 biolink:NamedThing spinal cord radial glial cell differentiation The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti radial glial cell differentiation in spinal cord biological_process owl:Class
GO:0061116 biolink:NamedThing ductus venosus closure The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth. got7fsn_ti dph 2010-05-17T07:21:53Z biological_process owl:Class
GO:0048845 biolink:NamedThing venous blood vessel morphogenesis The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart. got7fsn_ti venous morphogenesis|vein morphogenesis biological_process owl:Class
GO:0021548 biolink:NamedThing pons development The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. got7fsn_ti biological_process owl:Class
GO:0000452 biolink:NamedThing snoRNA guided rRNA 2'-O-methylation The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation. got7fsn_ti snoRNA guided rRNA 2'-O-ribose methylation biological_process owl:Class
GO:0047815 biolink:NamedThing D-arabinonolactonase activity Catalysis of the reaction: D-arabinono-1,4-lactone + H(2)O = D-arabinonate + H(+). got7fsn_ti D-arabinono-1,4-lactone lactonohydrolase activity RHEA:23108|KEGG_REACTION:R02714|MetaCyc:D-ARABINONOLACTONASE-RXN|EC:3.1.1.30 molecular_function owl:Class
GO:0010118 biolink:NamedThing stomatal movement The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata). got7fsn_ti biological_process owl:Class
GO:0097438 biolink:NamedThing exit from dormancy The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. got7fsn_ti release from dormancy pr 2012-12-05T15:01:24Z biological_process owl:Class
GO:0044820 biolink:NamedThing mitotic telomere tethering at nuclear periphery The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a mitotic cell cycle. got7fsn_ti jl 2013-11-19T16:16:22Z biological_process owl:Class
GO:0070319 biolink:NamedThing Golgi to plasma membrane transport vesicle A transport vesicle that mediates transport from the Golgi to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis. got7fsn_ti Golgi to plasma membrane constitutive secretory pathway transport vesicle|Golgi-plasma membrane transport vesicle cellular_component owl:Class
GO:0061052 biolink:NamedThing negative regulation of cell growth involved in cardiac muscle cell development Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. got7fsn_ti dph 2010-02-25T01:11:30Z biological_process owl:Class
GO:0018813 biolink:NamedThing trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde). got7fsn_ti RHEA:27389|EC:4.1.2.45|UM-BBD_enzymeID:e0257 molecular_function owl:Class
GO:0035784 biolink:NamedThing nickel cation homeostasis Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell. got7fsn_ti nickel homeostasis bf 2011-04-05T09:55:14Z biological_process owl:Class
GO:0072208 biolink:NamedThing metanephric smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure. got7fsn_ti mah 2010-03-18T11:51:59Z biological_process owl:Class
GO:0019576 biolink:NamedThing aerobic fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen. got7fsn_ti aerobic fructose catabolism|aerobic fructose degradation|aerobic fructose breakdown biological_process owl:Class
GO:0006001 biolink:NamedThing fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose. got7fsn_ti fructose breakdown|fructose degradation|fructose catabolism biological_process owl:Class
GO:0072536 biolink:NamedThing interleukin-23 receptor complex A protein complex that binds interleukin-23 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits. got7fsn_ti IL-23 receptor complex mah 2011-01-14T02:51:14Z cellular_component owl:Class
GO:0016561 biolink:NamedThing protein import into peroxisome matrix, translocation The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation. got7fsn_ti peroxisome matrix protein import, translocation|protein translocation during protein import into peroxisome matrix|protein translocation during peroxisome matrix protein import|protein translocation during protein transport into peroxisome matrix|peroxisome receptor translocation|protein transport into peroxisome matrix, translocation biological_process owl:Class
GO:0065002 biolink:NamedThing intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore. got7fsn_ti intracellular protein membrane transport|intracellular membrane translocation of a protein|intracellular protein transport across a membrane Note that this term is not intended for use in annotating lateral movement within membranes. biological_process owl:Class
GO:0002684 biolink:NamedThing positive regulation of immune system process Any process that activates or increases the frequency, rate, or extent of an immune system process. got7fsn_ti up-regulation of immune system process|upregulation of immune system process|up regulation of immune system process|stimulation of immune system process|activation of immune system process biological_process owl:Class
GO:0042608 biolink:NamedThing T cell receptor binding Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. got7fsn_ti T-lymphocyte receptor binding|T-cell receptor binding|TCR binding|T lymphocyte receptor binding molecular_function owl:Class
GO:0004692 biolink:NamedThing cGMP-dependent protein kinase activity cGMP dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. got7fsn_ti STK23|ATP:protein phosphotransferase (cGMP-dependent) activity|PKG|guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity|PKG 1alpha|PKG II|PKG 1beta|cGMP-dependent protein kinase ibeta activity|3':5'-cyclic GMP-dependent protein kinase activity This reaction requires the presence of cGMP. Reactome:R-HSA-418549|MetaCyc:2.7.11.12-RXN|Reactome:R-HSA-418442|EC:2.7.11.12|Reactome:R-HSA-1475422|Reactome:R-HSA-1497853 molecular_function owl:Class
GO:0039545 biolink:NamedThing suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses. got7fsn_ti suppression by virus of host mitochondrial antiviral-signaling protein|suppression by virus of host MAVS activity|inhibition of host MAVS by virus https://github.com/geneontology/go-ontology/issues/21983 This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. bf 2012-01-19T02:37:20Z biological_process owl:Class
GO:0060748 biolink:NamedThing tertiary branching involved in mammary gland duct morphogenesis The branching process in which the mammary gland ducts form tertiary branches off of the secondary branches as part of diestrus and pregnancy. got7fsn_ti dph 2009-06-22T10:44:51Z biological_process owl:Class
GO:1990043 biolink:NamedThing 5' deoxyribonuclease (pyrimidine dimer) activity Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate. got7fsn_ti pr 2013-02-15T12:16:51Z molecular_function owl:Class
GO:0033892 biolink:NamedThing deoxyribonuclease (pyrimidine dimer) activity Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate. got7fsn_ti bacteriophage T4 endodeoxyribonuclease V activity|endodeoxyribonuclease (pyrimidine dimer) activity|T4 endonuclease V activity MetaCyc:3.1.25.1-RXN|EC:3.1.25.1 molecular_function owl:Class
GO:1905331 biolink:NamedThing negative regulation of morphogenesis of an epithelium Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium. got7fsn_ti inhibition of morphogenesis of an epithelium|down regulation of morphogenesis of an epithelium|inhibition of epithelium morphogenesis|down-regulation of morphogenesis of an epithelium|negative regulation of epithelium morphogenesis|down regulation of epithelium morphogenesis|downregulation of morphogenesis of an epithelium|downregulation of epithelium morphogenesis|down-regulation of epithelium morphogenesis An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). bhm 2016-07-22T07:13:57Z biological_process owl:Class
GO:0035225 biolink:NamedThing determination of genital disc primordium Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two. got7fsn_ti biological_process owl:Class
GO:0034938 biolink:NamedThing pyrrole-2-carboxylate monooxygenase activity Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O. got7fsn_ti EC:1.14.14.-|UM-BBD_reactionID:r0968 molecular_function owl:Class
GO:0047400 biolink:NamedThing phosphonoacetate hydrolase activity Catalysis of the reaction: H(2)O + phosphonoacetate = acetate + H(+) + phosphate. got7fsn_ti phosphonoacetate phosphonohydrolase activity EC:3.11.1.2|MetaCyc:3.11.1.2-RXN|RHEA:16749|KEGG_REACTION:R00318 molecular_function owl:Class
GO:0016827 biolink:NamedThing hydrolase activity, acting on acid carbon-phosphorus bonds Catalysis of the hydrolysis of any acid carbon-phosphorus bond. got7fsn_ti EC:3.11.-.- molecular_function owl:Class
GO:0048650 biolink:NamedThing caste determination, influence by environmental factors The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. got7fsn_ti biological_process owl:Class
GO:0034626 biolink:NamedThing fatty acid elongation, polyunsaturated fatty acid Elongation of a fatty acid chain into which two or more C-C double bonds have been introduced. got7fsn_ti biological_process owl:Class
GO:0019368 biolink:NamedThing fatty acid elongation, unsaturated fatty acid Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced. got7fsn_ti MetaCyc:PWY0-862 biological_process owl:Class
GO:0021619 biolink:NamedThing hypoglossal nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. got7fsn_ti CN XII maturation biological_process owl:Class
GO:0006544 biolink:NamedThing glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. got7fsn_ti glycine metabolism biological_process owl:Class
GO:0052894 biolink:NamedThing norspermine:oxygen oxidoreductase activity Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide. got7fsn_ti norspermine oxidase activity MetaCyc:RXN-10464|EC:1.5.3.16 molecular_function owl:Class
GO:0051668 biolink:NamedThing localization within membrane Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane. got7fsn_ti establishment and maintenance of localization in membrane|positioning within membrane|establishment and maintenance of position in membrane|localisation within membrane|localization to membrane biological_process owl:Class
GO:0102924 biolink:NamedThing gibberellin A44,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: 2 H+ + gibberellin A44 + 2-oxoglutarate + O2 = gibberellin A98 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-886 molecular_function owl:Class
GO:0052163 biolink:NamedThing symbiont defense to host-produced nitric oxide Any process in which a symbiont modulates the frequency, rate or extent of the production of nitric oxide as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti evasion or tolerance by organism of host NO|defense response to host innate immune response nitric oxide production|response to defense-related nitric oxide production by other organism involved in symbiotic interaction|evasion or tolerance by organism of host nitric oxide|modulation by organism of defense-related host NO production|evasion or tolerance of NO produced by host in response to organism|evasion or tolerance by organism of nitric oxide produced by other organism involved in symbiotic interaction|modulation by symbiont of defense-related host nitric oxide production|modulation by organism of defense-related nitric oxide production in other organism involved in symbiotic interaction|evasion or tolerance by organism of host-produced NO|evasion or tolerance by organism of host-produced nitric oxide|evasion or tolerance by symbiont of host-produced nitric oxide|response to defense-related host nitric oxide production|evasion or tolerance of nitric oxide produced by host in response to organism https://github.com/geneontology/go-ontology/issues/18798 GO:0052376|GO:0052060|GO:0052302|GO:0052565|GO:0052551 biological_process owl:Class
GO:0048774 biolink:NamedThing cyanophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes. got7fsn_ti cyanophore cell differentiation biological_process owl:Class
GO:0018648 biolink:NamedThing methanesulfonate monooxygenase activity Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O. got7fsn_ti methanesulfonate,NADH:oxygen oxidoreductase activity|mesylate monooxygenase activity|methanesulphonic acid monooxygenase activity|methanesulfonic acid monooxygenase activity|methanesulfonate,FMNH2:oxygen oxidoreductase activity|MSA monooxygenase activity|MSAMO activity RHEA:26077|EC:1.14.13.111|MetaCyc:RXN-9770 molecular_function owl:Class
GO:0070828 biolink:NamedThing heterochromatin organization Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin. got7fsn_ti heterochromatin organisation mah 2009-07-23T04:12:48Z biological_process owl:Class
GO:0048706 biolink:NamedThing embryonic skeletal system development The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. got7fsn_ti embryonic skeletal development biological_process owl:Class
GO:1990213 biolink:NamedThing negative regulation by symbiont of salicylic acid levels in host Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-09T19:06:19Z biological_process owl:Class
GO:0052150 biolink:NamedThing modulation by symbiont of host apoptotic process Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host apoptosis|modulation by organism of host apoptotic programmed cell death Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'regulation of apoptosis ; GO:0042981'. biological_process owl:Class
GO:0051709 biolink:NamedThing regulation of killing of cells of other organism Any process that modulates the frequency, rate or extent of the killing by an organism of cells in another organism. got7fsn_ti modulation by organism of apoptotic process in other organism involved in symbiotic interaction|regulation of killing of cells of another organism|modulation of programmed cell death in other organism involved in symbiotic interaction|modulation of programmed cell death in other organism https://github.com/geneontology/go-ontology/issues/20287 jl 2012-03-20T04:48:41Z GO:0052248|GO:0044531|GO:0052459|GO:0052433 biological_process owl:Class
GO:0140108 biolink:NamedThing high-affinity glucose transmembrane transporter activity Enables the transfer of glucose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14212 pg 2017-10-12T10:06:19Z molecular_function owl:Class
GO:0005355 biolink:NamedThing glucose transmembrane transporter activity Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other. got7fsn_ti lactose/glucose efflux transporter activity|glucose permease activity|galactose/glucose (methylgalactoside) porter activity GO:0015579 Reactome:R-HSA-5653873|Reactome:R-HSA-499981 molecular_function owl:Class
GO:0033552 biolink:NamedThing response to vitamin B3 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus. got7fsn_ti response to nicotinamide|response to niacin biological_process owl:Class
GO:0038009 biolink:NamedThing regulation of signal transduction by receptor internalization Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway. got7fsn_ti regulation of signaling pathway by receptor endocytosis bf 2011-06-23T03:28:47Z biological_process owl:Class
GO:0086070 biolink:NamedThing SA node cell to atrial cardiac muscle cell communication The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti sinus node cardiomyocyte to atrial cardiomyocyte communication|sinoatrial node cardiomyocyte to atrial cardiomyocyte communication|SA node cardiac muscle cell to atrial cardiac muscle cell communication|SAN cardiomyocyte to atrial cardiomyocyte communication|SA node cardiomyocyte to atrial cardiomyocyte communication dph 2011-11-22T09:32:45Z biological_process owl:Class
GO:0086065 biolink:NamedThing cell communication involved in cardiac conduction Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti dph 2011-11-22T08:57:02Z biological_process owl:Class
GO:0031160 biolink:NamedThing spore wall The specialized envelope lying outside the cell membrane of a spore. got7fsn_ti spore coat cellular_component owl:Class
GO:0000467 biolink:NamedThing exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0000459 biolink:NamedThing exonucleolytic trimming involved in rRNA processing Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule. got7fsn_ti exonucleolytic trimming during rRNA processing biological_process owl:Class
GO:0044643 biolink:NamedThing envenomation resulting in positive regulation of complement activation, alternative pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism. got7fsn_ti jl 2012-07-11T11:56:48Z biological_process owl:Class
GO:0044642 biolink:NamedThing envenomation resulting in modulation of complement activation, alternative pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism. got7fsn_ti envenomation resulting in regulation of complement activation, alternative pathway in other organism jl 2012-07-11T11:53:12Z biological_process owl:Class
GO:0031653 biolink:NamedThing heat dissipation Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature. got7fsn_ti biological_process owl:Class
GO:0050429 biolink:NamedThing calcium-dependent phospholipase C activity Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+. got7fsn_ti molecular_function owl:Class
GO:0021983 biolink:NamedThing pituitary gland development The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. got7fsn_ti hypophysis development biological_process owl:Class
GO:0031256 biolink:NamedThing leading edge membrane The portion of the plasma membrane surrounding the leading edge of a motile cell. got7fsn_ti cellular_component owl:Class
GO:0018186 biolink:NamedThing peroxidase-heme linkage The covalent linkage of heme to peroxidase. got7fsn_ti peroxidase-haem linkage RESID:AA0280|RESID:AA0279 biological_process owl:Class
GO:0040035 biolink:NamedThing hermaphrodite genitalia development The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures. got7fsn_ti biological_process owl:Class
GO:0060512 biolink:NamedThing prostate gland morphogenesis The process in which the anatomical structures of a prostate gland are generated and organized. got7fsn_ti biological_process owl:Class
GO:0006402 biolink:NamedThing mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. got7fsn_ti mRNA catabolism|mRNA breakdown|mRNA degradation|mRNA decay biological_process owl:Class
GO:0002123 biolink:NamedThing irritable aggressive behavior Aggressive behavior induced by frustration and directed against an available target. got7fsn_ti irritable aggression biological_process owl:Class
GO:0061705 biolink:NamedThing sucrose catabolic process to fructose-6-phosphate through glucose and fructose The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates. got7fsn_ti dph 2015-06-11T13:32:05Z MetaCyc:PWY-621 biological_process owl:Class
GO:0005987 biolink:NamedThing sucrose catabolic process The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside. got7fsn_ti sucrose catabolism|sucrose breakdown|sucrose degradation biological_process owl:Class
GO:0060404 biolink:NamedThing axonemal microtubule depolymerization The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules. got7fsn_ti biological_process owl:Class
GO:0140028 biolink:NamedThing pore formation during contractile vacuole discharge The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes. got7fsn_ti pg 2017-05-15T12:20:27Z biological_process owl:Class
GO:0140029 biolink:NamedThing exocytic process The cellular processes that contribute to exocytosis. got7fsn_ti pg 2017-05-15T13:20:45Z biological_process owl:Class
GO:0018586 biolink:NamedThing mono-butyltin dioxygenase activity Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin. got7fsn_ti MBT dioxygenase activity UM-BBD_reactionID:r0647 molecular_function owl:Class
GO:0002211 biolink:NamedThing behavioral defense response to insect A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism. got7fsn_ti behavioural defense response to insect biological_process owl:Class
GO:0033901 biolink:NamedThing ribonuclease V activity Catalysis of the hydrolysis of poly(A), forming oligoribonucleotides and ultimately 3'-AMP. got7fsn_ti endoribonuclease V activity MetaCyc:3.1.27.8-RXN|EC:3.1.27.8 molecular_function owl:Class
GO:0016892 biolink:NamedThing endoribonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. got7fsn_ti endoribonuclease activity, producing other than 5'-phosphomonoesters EC:3.1.27.- molecular_function owl:Class
GO:0021799 biolink:NamedThing cerebral cortex radially oriented cell migration The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. got7fsn_ti biological_process owl:Class
GO:0033858 biolink:NamedThing N-acetylgalactosamine kinase activity Catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate. got7fsn_ti GK2|GALK2|GalNAc kinase activity|ATP:N-acetyl-D-galactosamine 1-phosphotransferase activity|N-acetylgalactosamine (GalNAc)-1-phosphate kinase activity RHEA:12617|EC:2.7.1.157|MetaCyc:2.7.1.157-RXN molecular_function owl:Class
GO:0035512 biolink:NamedThing hydrolytic DNA demethylation The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule. got7fsn_ti bf 2010-04-30T02:24:21Z biological_process owl:Class
GO:0080111 biolink:NamedThing DNA demethylation The removal of a methyl group from one or more nucleotides within an DNA molecule. got7fsn_ti dhl 2009-04-27T02:42:05Z biological_process owl:Class
GO:0050746 biolink:NamedThing regulation of lipoprotein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. got7fsn_ti regulation of lipoprotein metabolism biological_process owl:Class
GO:0000277 biolink:NamedThing [cytochrome c]-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c. got7fsn_ti S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity|cytochrome c-specific protein methylase III activity|cytochrome c methyltransferase activity|cytochrome c-specific protein-lysine methyltransferase activity|cytochrome c (lysine) methyltransferase activity|cytochrome c-lysine N-methyltransferase activity|S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity RHEA:24312|EC:2.1.1.59|MetaCyc:2.1.1.59-RXN molecular_function owl:Class
GO:0044161 biolink:NamedThing host cell cytoplasmic vesicle A vesicle formed of membrane or protein, found in the cytoplasm of a host cell. got7fsn_ti jl 2009-08-11T04:22:21Z cellular_component owl:Class
GO:0036407 biolink:NamedThing mycolate outer membrane A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria). got7fsn_ti mycomembrane|mycolate outer membrane|MOM|mycobacterial outer membrane bf 2013-08-15T13:33:46Z cellular_component owl:Class
GO:0009279 biolink:NamedThing cell outer membrane A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. got7fsn_ti outer membrane of cell To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886. cellular_component owl:Class
GO:0033380 biolink:NamedThing granzyme B localization to T cell secretory granule Any process in which the protease granzyme B is transported to, or maintained in, a location within a secretory granule in a T cell. got7fsn_ti granzyme B localization in T cell secretory granule|granzyme B localization in T-lymphocyte secretory granule|granzyme B localization in T lymphocyte secretory granule|granzyme B localisation in T cell secretory granule|granzyme B localization in T-cell secretory granule biological_process owl:Class
GO:0033375 biolink:NamedThing protease localization to T cell secretory granule Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a T cell. got7fsn_ti protease localization in T-lymphocyte secretory granule|protease localization in T-cell secretory granule|protease localisation in T cell secretory granule|protease localization in T lymphocyte secretory granule|protease localization in T cell secretory granule biological_process owl:Class
GO:1901657 biolink:NamedThing glycosyl compound metabolic process The chemical reactions and pathways involving glycosyl compound. got7fsn_ti glycosyl compound metabolism pr 2012-11-20T14:24:07Z biological_process owl:Class
GO:0044478 biolink:NamedThing envenomation resulting in positive regulation of platelet aggregation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism. got7fsn_ti jl 2012-01-19T02:39:45Z biological_process owl:Class
GO:0044469 biolink:NamedThing envenomation resulting in positive regulation of blood coagulation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism. got7fsn_ti jl 2012-01-19T01:29:09Z biological_process owl:Class
GO:1990038 biolink:NamedThing Lewy body corona The periphery of a Lewy body. In Parkinson's disease, it contains spherical accumulations of filaments arranged in a loose, radiating array. got7fsn_ti halo pr 2013-02-08T13:03:27Z NIF_Subcellular:sao5764355747 cellular_component owl:Class
GO:0106363 biolink:NamedThing protein-cysteine methyltransferase activity Catalysis of the reaction: L-cysteinyl-[protein] + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + S-methyl-L-cysteinyl-[protein]. got7fsn_ti hjd 2021-02-05T15:44:58Z RHEA:66544 molecular_function owl:Class
GO:0044307 biolink:NamedThing dendritic branch A dendrite arising from another dendrite. got7fsn_ti dendrite branch|secondary dendrite jl 2010-02-05T04:18:53Z NIF_Subcellular:sao884265541 cellular_component owl:Class
GO:0006360 biolink:NamedThing transcription by RNA polymerase I The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter. got7fsn_ti transcription from RNA polymerase I promoter|transcription from Pol I promoter|RNA polymerase I transcription factor activity https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0009819 biolink:NamedThing drought recovery Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition. got7fsn_ti drought tolerance biological_process owl:Class
GO:0018640 biolink:NamedThing dibenzothiophene monooxygenase activity Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O. got7fsn_ti RHEA:49076|UM-BBD_enzymeID:e0214|MetaCyc:RXN-621 molecular_function owl:Class
GO:1903523 biolink:NamedThing negative regulation of blood circulation Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation. got7fsn_ti down regulation of hemolymph circulation|negative regulation of hemolymph circulation|down-regulation of hemolymph circulation|inhibition of hemolymph circulation|inhibition of blood circulation|down-regulation of blood circulation|down regulation of blood circulation|downregulation of blood circulation|downregulation of hemolymph circulation mr 2014-10-06T18:39:05Z biological_process owl:Class
GO:0002755 biolink:NamedThing MyD88-dependent toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. got7fsn_ti MyD88-dependent toll-like receptor signalling pathway|MyD88-dependent TLR signaling pathway biological_process owl:Class
GO:0046676 biolink:NamedThing negative regulation of insulin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. got7fsn_ti down regulation of insulin secretion|downregulation of insulin secretion|down-regulation of insulin secretion|inhibition of insulin secretion biological_process owl:Class
GO:0009824 biolink:NamedThing AMP dimethylallyltransferase activity Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate. got7fsn_ti adenylate dimethylallyltransferase activity|isopentenyltransferase activity|2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity|dimethylallyl-diphosphate:AMP dimethylallyltransferase activity|adenylate isopentenyltransferase activity|cytokinin synthase activity|2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity MetaCyc:RXN-4307|RHEA:15285|EC:2.5.1.27|KEGG_REACTION:R04038 molecular_function owl:Class
GO:0019772 biolink:NamedThing low-affinity IgG receptor activity Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti low affinity Fc receptor activity|low affinity IgG receptor activity molecular_function owl:Class
GO:0009251 biolink:NamedThing glucan catabolic process The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues. got7fsn_ti glucan breakdown|glucan catabolism|glucan degradation biological_process owl:Class
GO:0000272 biolink:NamedThing polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. got7fsn_ti polysaccharide breakdown|multicellular organismal polysaccharide catabolic process|polysaccharide catabolism|polysaccharide degradation GO:0044244 biological_process owl:Class
GO:0047071 biolink:NamedThing 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+). got7fsn_ti 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)|3-alkylcatechol 2,3-dioxygenase activity|steroid 4,5-dioxygenase activity EC:1.13.11.25|RHEA:21352|UM-BBD_reactionID:r1151|MetaCyc:1.13.11.25-RXN|KEGG_REACTION:R04597 molecular_function owl:Class
GO:0060116 biolink:NamedThing vestibular receptor cell morphogenesis Any process that alters the size or shape of a vestibular receptor cell. got7fsn_ti vestibular hair cell morphogenesis biological_process owl:Class
GO:0043685 biolink:NamedThing conversion of glutamyl-tRNA to glutaminyl-tRNA The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA. got7fsn_ti Note that this process has been observed in some archaeal and bacterial species. biological_process owl:Class
GO:0070744 biolink:NamedThing interleukin-27 complex A protein complex that is composed of an interleukin-27p28 subunit (product of the IL27 gene) and an EBI3 subunit and is secreted into the extracellular space. got7fsn_ti IL-27 complex|p28|EBI3|IL27 Note that this heterodimeric cytokine utilizes the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-35 uses for its beta chain. Also note that the product of the IL27 gene is the alpha subunit of IL-27. The functional IL-27 protein complex requires both subunits. mah 2009-06-23T01:09:58Z cellular_component owl:Class
GO:0018897 biolink:NamedThing dibenzothiophene desulfurization The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. got7fsn_ti dibenzothiophene desulphurization UM-BBD_pathwayID:dbt|MetaCyc:PWY-681 biological_process owl:Class
GO:0018895 biolink:NamedThing dibenzothiophene metabolic process The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion. got7fsn_ti diphenylene sulfide metabolic process|diphenylene sulfide metabolism|dibenzothiophene metabolism biological_process owl:Class
GO:0061631 biolink:NamedThing ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2|HECT E3 dph 2014-05-18T09:25:19Z EC:2.3.2.23 molecular_function owl:Class
GO:0014849 biolink:NamedThing ureter smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder. got7fsn_ti biological_process owl:Class
GO:0008898 biolink:NamedThing S-adenosylmethionine-homocysteine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. got7fsn_ti S-adenosylmethionine:homocysteine methyltransferase activity|S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity|adenosylmethionine:homocysteine methyltransferase activity|S-adenosylmethionine-homocysteine transmethylase activity|adenosylmethionine transmethylase activity|L-homocysteine S-methyltransferase activity|homocysteine methyltransferase activity|S-adenosylmethionine homocysteine transmethylase activity|homocysteine transmethylase activity|S-adenosyl-L-methionine:L-homocysteine methyltransferase activity RHEA:21820|MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0019921 biolink:NamedThing peptidyl-1-thioglycine biosynthetic process, carboxy-terminal The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond. got7fsn_ti peptidyl-1-thioglycine formation, carboxy-terminal|peptidyl-1-thioglycine synthesis, carboxy-terminal|peptidyl-1-thioglycine anabolism, carboxy-terminal RESID:AA0265 biological_process owl:Class
GO:0034001 biolink:NamedThing chondroitin-sulfate-ABC exolyase activity Catalysis of the exolytic cleavage of disaccharide residues from the non-reducing ends of both polymeric chondroitin sulfates and their oligosaccharide fragments. got7fsn_ti chondroitin ABC eliminase activity|chondroitin sulfate ABC exoeliminase activity|ChS ABC lyase activity|ChS ABC lyase II activity|chondroitin sulfate ABC exolyase activity|chondroitinase ABC activity|chondroitinase activity|chondroitin sulfate ABC lyase activity MetaCyc:4.2.2.21-RXN|EC:4.2.2.21 molecular_function owl:Class
GO:0047486 biolink:NamedThing chondroitin ABC lyase activity Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. got7fsn_ti molecular_function owl:Class
GO:0035187 biolink:NamedThing hatching behavior The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell. got7fsn_ti hatching behaviour biological_process owl:Class
GO:0033606 biolink:NamedThing chemokine receptor transport within lipid bilayer The directed movement of a chemokine receptor within a lipid bilayer. got7fsn_ti chemokine receptor translocation within membrane biological_process owl:Class
GO:0097721 biolink:NamedThing ciliary vesicle A Golgi-derived vesicle to which the ciliary basal body docks via its transitional fibers. Its membrane is compositionally distinct from Golgi membranes, and will become the ciliary membrane once the ciliary vesicle is fused to the plasma membrane. The ciliary vesicle is thought to be formed by multiple smaller vesicles that attach to the transitional fibers and then fuse to form a larger vesicle. got7fsn_ti CV|primary ciliary vesicle pr 2016-08-30T13:54:38Z cellular_component owl:Class
GO:0061374 biolink:NamedThing mammillothalamic axonal tract development The progression of the mammillothalamic axonal tract, from its formation to the mature structure. The mammillothalamic tract is the collection of axons that connects the two major subdivisions of the diencephalon (hypothalamus and thalamus) and closes the diencephalic circuit. got7fsn_ti dph 2010-11-09T08:54:43Z biological_process owl:Class
GO:0044781 biolink:NamedThing bacterial-type flagellum organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility. got7fsn_ti jl 2013-03-27T15:07:00Z biological_process owl:Class
GO:0031993 biolink:NamedThing light transducer activity Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell. got7fsn_ti molecular_function owl:Class
GO:0031992 biolink:NamedThing energy transducer activity The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell. got7fsn_ti photon capture|light harvesting activity molecular_function owl:Class
GO:0039587 biolink:NamedThing suppression by virus of host tetherin activity Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects. got7fsn_ti inhibition of host BST2/Tetherin by virus|suppression by virus of host BST-2 activity bf 2012-05-04T02:33:29Z VZ:665 biological_process owl:Class
GO:0039506 biolink:NamedThing modulation by virus of host molecular function The process in which a virus effects a change in the function of a host protein via a direct interaction. got7fsn_ti modification by virus of host protein function bf 2011-06-02T02:38:42Z biological_process owl:Class
GO:0005200 biolink:NamedThing structural constituent of cytoskeleton The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. got7fsn_ti molecular_function owl:Class
GO:0030762 biolink:NamedThing tetrahydrocolumbamine 2-O-methyltransferase activity Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine. got7fsn_ti tetrahydrocolumbamine methyltransferase activity|S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity MetaCyc:2.1.1.89-RXN|RHEA:22536|KEGG_REACTION:R04077|EC:2.1.1.89 molecular_function owl:Class
GO:0030267 biolink:NamedThing glyoxylate reductase (NADP+) activity Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+. got7fsn_ti glyoxylate reductase (NADP+)|NADPH-glyoxylate reductase activity|glycolate:NADP+ oxidoreductase activity RHEA:10992|Reactome:R-HSA-389826|Wikipedia:Glyoxylate_reductase_(NADP+)|MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN|EC:1.1.1.79 molecular_function owl:Class
GO:0106345 biolink:NamedThing glyoxylate reductase activity Catalysis of the reaction: glycolate + NAD(P)+ = glyoxylate + NAD(P)H. got7fsn_ti hjd 2020-12-08T14:14:31Z molecular_function owl:Class
GO:0045852 biolink:NamedThing pH elevation Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. got7fsn_ti biological_process owl:Class
GO:0006885 biolink:NamedThing regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. got7fsn_ti hydrogen ion homeostasis biological_process owl:Class
GO:0030241 biolink:NamedThing skeletal muscle myosin thick filament assembly The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle. got7fsn_ti biological_process owl:Class
GO:0071688 biolink:NamedThing striated muscle myosin thick filament assembly The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle. got7fsn_ti mah 2010-02-25T03:52:21Z biological_process owl:Class
GO:0032019 biolink:NamedThing mitochondrial cloud A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material. got7fsn_ti Balbiani body|mitochondrial aggregate cellular_component owl:Class
GO:0039574 biolink:NamedThing suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK1-STAT signaling cascade in a host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits. got7fsn_ti suppression by virus of host TYK2 activity|suppression by virus of host non-receptor tyrosine-protein kinase TYK2 activity https://github.com/geneontology/go-ontology/issues/21986 bf biological_process owl:Class
GO:0039514 biolink:NamedThing suppression by virus of host JAK-STAT cascade Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signal cascade in the host organism. got7fsn_ti down-regulation by virus of host JAK-STAT cascade|inhibition by virus of host JAK-STAT cascade|negative regulation by virus of host JAK-STAT cascade|downregulation by virus of host JAK-STAT cascade bf 2011-06-16T02:48:03Z biological_process owl:Class
GO:0050326 biolink:NamedThing taxifolin 8-monooxygenase activity Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O. got7fsn_ti taxifolin hydroxylase activity|taxifolin,NAD(P)H:oxygen oxidoreductase (8-hydroxylating) EC:1.14.13.19|MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0031942 biolink:NamedThing i-AAA complex Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases. got7fsn_ti cellular_component owl:Class
GO:0010338 biolink:NamedThing leaf formation The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti biological_process owl:Class
GO:0099402 biolink:NamedThing plant organ development Development of a plant organ, a multi-tissue plant structure that forms a functional unit. got7fsn_ti development of a plant organ biological_process owl:Class
GO:0008412 biolink:NamedThing 4-hydroxybenzoate octaprenyltransferase activity Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate. got7fsn_ti 4-HB polyprenyltransferase activity|para-hydroxybenzoate:polyprenyltransferase activity|para-hydroxybenzoate transferase activity|PHB polyprenyl diphosphate transferase activity|para-hydroxybenzoate-polyprenyl diphosphate transferase activity GO:0048044|GO:0000043|GO:0048043 EC:2.5.1.39|MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN|RHEA:27782 molecular_function owl:Class
GO:0021749 biolink:NamedThing ventral cochlear nucleus development The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0042424 biolink:NamedThing catecholamine catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. got7fsn_ti catecholamine degradation|catecholamine catabolism|catecholamine breakdown biological_process owl:Class
GO:0090531 biolink:NamedThing L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose. got7fsn_ti L-ascorbic acid biosynthesis via GDP-alpha-D-mannose|Smirnoff-Wheeler's pathway tb 2013-02-06T15:31:01Z BioCyc:PWY-882 biological_process owl:Class
GO:0042733 biolink:NamedThing embryonic digit morphogenesis The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. got7fsn_ti biological_process owl:Class
GO:0070532 biolink:NamedThing BRCA1-B complex A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites. got7fsn_ti cellular_component owl:Class
GO:0021973 biolink:NamedThing corticospinal neuron axon decussation The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side. got7fsn_ti biological_process owl:Class
GO:0016199 biolink:NamedThing axon midline choice point recognition The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline. got7fsn_ti biological_process owl:Class
GO:0097124 biolink:NamedThing cyclin A2-CDK2 complex A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:44:19Z cellular_component owl:Class
GO:0008022 biolink:NamedThing protein C-terminus binding Binding to a protein C-terminus, the end of a peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. got7fsn_ti carboxy-terminus binding|carboxyl-terminus binding|COOH-terminus binding|C-terminal end binding|COOH-terminal binding|C-terminal binding|carboxy-terminal binding|carboxylate-terminus binding|carboxyl-terminal binding|carboxylate-terminal binding molecular_function owl:Class
GO:1990469 biolink:NamedThing Rhino-Deadlock-Cutoff Complex Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation. got7fsn_ti RDC complex|rhi-del-cuff complex An example of this is cuff in Drosophila melanogaster (Q9V629) in PMID:24906153. bhm 2014-08-29T14:08:37Z cellular_component owl:Class
GO:0046806 biolink:NamedThing viral scaffold A complex of proteins that form a scaffold around which the viral capsid is constructed. got7fsn_ti cellular_component owl:Class
GO:0034038 biolink:NamedThing deoxyhypusine synthase activity Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+. got7fsn_ti eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity|spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity|eIF-5A-deoxyhypusine synthase activity Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'. Reactome:R-HSA-204617|MetaCyc:2.5.1.46-RXN|EC:2.5.1.46|Reactome:R-HSA-204647|RHEA:33299 molecular_function owl:Class
GO:0097468 biolink:NamedThing programmed cell death in response to reactive oxygen species Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. got7fsn_ti reactive oxygen species-mediated programmed cell death|PCD in response to reactive oxygen species|reactive oxygen species-mediated PCD|programmed cell death in response to oxidative stress|PCD in response to oxidative stress pr 2013-02-19T10:03:36Z biological_process owl:Class
GO:0042752 biolink:NamedThing regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours. got7fsn_ti biological_process owl:Class
GO:0052627 biolink:NamedThing vanillate amino acid synthetase activity Catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate. got7fsn_ti molecular_function owl:Class
GO:0060614 biolink:NamedThing negative regulation of mammary gland development in males by androgen receptor signaling pathway Any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell. got7fsn_ti negative regulation of mammary gland development in males by androgen receptor signalling pathway dph 2009-05-18T08:34:40Z biological_process owl:Class
GO:1990790 biolink:NamedThing response to glial cell derived neurotrophic factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. got7fsn_ti response to ATF|response to GDNF|response to astrocyte-derived trophic factor sl 2015-07-02T19:47:05Z biological_process owl:Class
GO:0070343 biolink:NamedThing white fat cell proliferation The multiplication or reproduction of white fat cells by cell division, resulting in the expansion of their population. got7fsn_ti white adipose cell proliferation|white adipocyte proliferation biological_process owl:Class
GO:0022853 biolink:NamedThing active ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. got7fsn_ti molecular_function owl:Class
GO:0015075 biolink:NamedThing ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other. got7fsn_ti ion transporter activity molecular_function owl:Class
GO:0018864 biolink:NamedThing acetylene metabolic process The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes. got7fsn_ti acetylene metabolism|ethyne metabolic process|ethyne metabolism UM-BBD_pathwayID:atl biological_process owl:Class
GO:0003313 biolink:NamedThing heart rudiment development The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. got7fsn_ti heart cone development dph 2009-10-27T08:32:40Z biological_process owl:Class
GO:0033102 biolink:NamedThing acidocalcisome membrane The lipid bilayer surrounding an acidocalcisome. got7fsn_ti cellular_component owl:Class
GO:1990942 biolink:NamedThing mitotic metaphase chromosome recapture A mechanism to recapture 'lost' chromosomes (chromosomes which have become detached from the spindle) during metaphase of mitotic chromosome segregation. Chromosomes with unattached kinetochores are migrated along (non polar) spindle microtubules to the mitotic spindle pole body by a combination of microtubule depolymerisation and 'kinetochore sliding' (migration of the chromosome along the microtubule). The chromosome subsequently migrates along the polar spindle microtubule to the metaphase plate. got7fsn_ti microtubule sliding involved in sister kinetochore recapture|kinetochore retrieval|microtubule sliding involved in mitotic metaphase chromosome recapture|sister kinetochore recapture|metaphase chromosome retrieval to the spindle pole body|microtubule sliding involved in metaphase chromosome retrieval to the spindle pole body|microtubule sliding involved in kinetochore retrieval vw 2016-04-06T14:41:56Z GO:1905185 biological_process owl:Class
GO:0042020 biolink:NamedThing interleukin-23 receptor activity Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-23 receptor activity|IL-23R molecular_function owl:Class
GO:0018613 biolink:NamedThing 9-fluorenone dioxygenase activity Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone. got7fsn_ti EC:1.14.12.-|UM-BBD_reactionID:r0409 molecular_function owl:Class
GO:0080147 biolink:NamedThing root hair cell development The process whose specific outcome is the progression of a root hair cell over time, from its formation to the mature state. got7fsn_ti dhl 2010-03-26T01:45:08Z biological_process owl:Class
GO:0010544 biolink:NamedThing negative regulation of platelet activation Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. got7fsn_ti biological_process owl:Class
GO:0097589 biolink:NamedThing archaeal-type flagellum A non-membrane-bounded organelle superficially similar to a bacterial-type flagellum; they both consist of filaments extending outside the cell, and rotate to propel the cell, but the archaeal flagella (also called archaella) have a unique structure which lacks a central channel. Similar to bacterial type IV pilins, the archaeal flagellins (archaellins) are made with class 3 signal peptides and they are processed by a type IV prepilin peptidase-like enzyme. The archaellins are typically modified by the addition of N-linked glycans which are necessary for proper assembly and/or function. got7fsn_ti archaella|archaellum|archaeal flagellum pr 2014-03-25T20:36:24Z cellular_component owl:Class
GO:0060611 biolink:NamedThing mammary gland fat development The progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts. got7fsn_ti dph 2009-05-15T12:27:57Z biological_process owl:Class
GO:0047660 biolink:NamedThing amidinoaspartase activity Catalysis of the reaction: N-amidino-L-aspartate + H(2)O = L-aspartate + urea. got7fsn_ti N-amidino-L-aspartate amidinohydrolase activity|amidinoaspartic amidinohydrolase activity MetaCyc:AMIDINOASPARTASE-RXN|KEGG_REACTION:R00777|RHEA:14849|EC:3.5.3.14 molecular_function owl:Class
GO:0030650 biolink:NamedThing peptide antibiotic metabolic process The chemical reactions and pathways involving peptides with antibiotic activity. got7fsn_ti peptide antibiotic metabolism biological_process owl:Class
GO:0034020 biolink:NamedThing neoxanthin synthase activity Catalysis of the reaction: all-trans-violaxanthin = all-trans-neoxanthin. got7fsn_ti violaxanthin-neoxanthin isomerase (epoxide-opening) activity|NSY KEGG_REACTION:R06948|RHEA:10128|EC:5.3.99.9|MetaCyc:RXN1F-155 molecular_function owl:Class
GO:0035261 biolink:NamedThing external genitalia morphogenesis The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals. got7fsn_ti biological_process owl:Class
GO:0035112 biolink:NamedThing genitalia morphogenesis The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal. got7fsn_ti genital morphogenesis biological_process owl:Class
GO:0035590 biolink:NamedThing purinergic nucleotide receptor signaling pathway The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity. got7fsn_ti P2 receptor signaling pathway|purinergic receptor signaling pathway|purinergic nucleotide receptor signalling pathway|purinoceptor signaling pathway|purinergic receptor signalling pathway bf 2010-10-22T11:09:40Z GO:0035587 biological_process owl:Class
GO:0005984 biolink:NamedThing disaccharide metabolic process The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units. got7fsn_ti disaccharide metabolism biological_process owl:Class
GO:0070422 biolink:NamedThing G-protein beta/gamma-Raf-1 complex A protein complex formed by the association of the serine-threonine protein kinase Raf-1 with the beta and gamma subunits of a heterotrimeric G protein. got7fsn_ti G protein complex (GNG2, GNB2L1, RAF1) See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. cellular_component owl:Class
GO:0003415 biolink:NamedThing chondrocyte hypertrophy The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time. got7fsn_ti dph 2009-12-22T08:48:44Z biological_process owl:Class
GO:0003374 biolink:NamedThing dynamin family protein polymerization involved in mitochondrial fission The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission. got7fsn_ti dph 2009-12-09T05:39:52Z biological_process owl:Class
GO:0003373 biolink:NamedThing dynamin family protein polymerization involved in membrane fission The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission. got7fsn_ti dph 2009-12-09T04:55:16Z biological_process owl:Class
GO:0036081 biolink:NamedThing extracellular ammonia-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts. got7fsn_ti ionotropic ammonia receptor activity bf 2011-12-20T04:47:48Z molecular_function owl:Class
GO:0030437 biolink:NamedThing ascospore formation The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota). got7fsn_ti ascospore biosynthesis|spore formation|sporulation Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. GO:0007151 biological_process owl:Class
GO:0031829 biolink:NamedThing type 4 serotonin receptor binding Binding to a type 4 serotonin receptor. got7fsn_ti type 4 serotonin receptor ligand|5-hydroxytryptamine 4 receptor binding molecular_function owl:Class
GO:0102124 biolink:NamedThing gibberellin A12 16alpha,17 epoxidase activity Catalysis of the reaction: gibberellin A12 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A12 + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-11387 molecular_function owl:Class
GO:0021827 biolink:NamedThing postnatal olfactory bulb interneuron migration The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth. got7fsn_ti biological_process owl:Class
GO:0021823 biolink:NamedThing cerebral cortex tangential migration using cell-cell interactions The process in which neurons interact with each other to promote migration along a tangential plane. got7fsn_ti chain migration biological_process owl:Class
GO:0032077 biolink:NamedThing positive regulation of deoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid. got7fsn_ti up regulation of deoxyribonuclease activity|DNase activator|deoxyribonuclease activator|stimulation of deoxyribonuclease activity|upregulation of deoxyribonuclease activity|up-regulation of deoxyribonuclease activity|activation of deoxyribonuclease activity biological_process owl:Class
GO:0051054 biolink:NamedThing positive regulation of DNA metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA. got7fsn_ti activation of DNA metabolic process|positive regulation of DNA metabolism|stimulation of DNA metabolic process|up-regulation of DNA metabolic process|up regulation of DNA metabolic process|upregulation of DNA metabolic process biological_process owl:Class
GO:0140352 biolink:NamedThing export from cell The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis. got7fsn_ti efflux pg 2019-05-22T11:20:45Z biological_process owl:Class
GO:0090663 biolink:NamedThing galanin-activated signaling pathway The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor. got7fsn_ti galanin signaling pathway|galanin-activated signalling pathway|galanin signalling pathway tb 2015-10-21T13:38:04Z biological_process owl:Class
GO:0007218 biolink:NamedThing neuropeptide signaling pathway The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. got7fsn_ti neuropeptide signalling pathway biological_process owl:Class
GO:0042903 biolink:NamedThing tubulin deacetylase activity Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate. got7fsn_ti Reactome:R-HSA-5618331 molecular_function owl:Class
GO:0043982 biolink:NamedThing histone H4-K8 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone. got7fsn_ti histone H4 acetylation at K8 biological_process owl:Class
GO:0043967 biolink:NamedThing histone H4 acetylation The modification of histone H4 by the addition of an acetyl group. got7fsn_ti biological_process owl:Class
GO:0042150 biolink:NamedThing plasmid recombination A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules. got7fsn_ti biological_process owl:Class
GO:0060945 biolink:NamedThing cardiac neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart. got7fsn_ti heart neuron differentiation dph 2009-09-29T02:45:33Z biological_process owl:Class
GO:0000963 biolink:NamedThing mitochondrial RNA processing The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion. got7fsn_ti biological_process owl:Class
GO:0140053 biolink:NamedThing mitochondrial gene expression The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. got7fsn_ti pg 2017-06-26T10:57:45Z biological_process owl:Class
GO:0098061 biolink:NamedThing viral capsid, internal space The region of a virus contained within the capsid shell, and usually containing the viral genome and accessory proteins. got7fsn_ti internal head protein bm 2012-08-01T12:12:47Z cellular_component owl:Class
GO:0030466 biolink:NamedThing silent mating-type cassette heterochromatin assembly Repression of transcription at silent mating-type loci by alteration of the structure of chromatin. got7fsn_ti aging-dependent sterility|chromatin silencing at HML and HMR|chromatin silencing at silent mating-type cassette|silent mating-type cassette chromatin silencing|establishment of chromatin silencing at silent mating-type cassette|heterochromatic silencing at silent mating-type cassette https://github.com/geneontology/go-ontology/issues/19112 GO:0035389|GO:0006347 biological_process owl:Class
GO:0035759 biolink:NamedThing mesangial cell-matrix adhesion The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney. got7fsn_ti bf 2011-03-25T02:06:21Z biological_process owl:Class
GO:0007160 biolink:NamedThing cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. got7fsn_ti biological_process owl:Class
GO:0002307 biolink:NamedThing CD8-positive, alpha-beta regulatory T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell. got7fsn_ti CD8-positive, alpha-beta regulatory T-cell differentiation|CD8-positive, alpha-beta regulatory T lymphocyte differentiation|CD8-positive, alpha-beta regulatory T cell development|CD8-positive, alpha-beta regulatory T-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0103091 biolink:NamedThing 2-(7'-methylthio)heptylmalate synthase activity Catalysis of the reaction: 2-oxo-9-methylthiononanoate + acetyl-CoA + H2O <=> H+ + 2-(7'-methylthio)heptylmalate + coenzyme A. got7fsn_ti MetaCyc:RXNQT-4175 molecular_function owl:Class
GO:0043912 biolink:NamedThing D-lysine oxidase activity Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide. got7fsn_ti EC:1.4.3.- molecular_function owl:Class
GO:0050454 biolink:NamedThing coenzyme F420 hydrogenase activity Catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F420. got7fsn_ti F420-reducing hydrogenase activity|coenzyme F420-dependent hydrogenase activity|hydrogen:coenzyme F420 oxidoreductase activity|8-hydroxy-5-deazaflavin-reducing hydrogenase activity KEGG_REACTION:R03025|EC:1.12.98.1|MetaCyc:COENZYME-F420-HYDROGENASE-RXN|RHEA:23760 molecular_function owl:Class
GO:0046995 biolink:NamedThing oxidoreductase activity, acting on hydrogen as donor, with other known acceptors Catalysis of an oxidation-reduction (redox) reaction in which hydrogen reduces a known acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP, or a quinone or similar compound. got7fsn_ti EC:1.12.98.- molecular_function owl:Class
GO:0061802 biolink:NamedThing anterior cell cortex The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis. got7fsn_ti dph 2016-11-06T22:54:21Z cellular_component owl:Class
GO:0070557 biolink:NamedThing PCNA-p21 complex A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication. got7fsn_ti cellular_component owl:Class
GO:0015276 biolink:NamedThing ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti ionotropic receptor activity Reactome:R-HSA-629595|Reactome:R-HSA-622326|Reactome:R-HSA-451310|Reactome:R-HSA-622325|Reactome:R-HSA-451311 molecular_function owl:Class
GO:0033566 biolink:NamedThing gamma-tubulin complex localization Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location. got7fsn_ti establishment and maintenance of gamma-tubulin complex localization|gamma-tubulin complex localisation biological_process owl:Class
GO:0051629 biolink:NamedThing inhibition of epinephrine uptake Any process that prevents the activation of the directed movement of epinephrine into a cell. got7fsn_ti inhibition of adrenaline uptake|inhibition of epinephrine import biological_process owl:Class
GO:0043686 biolink:NamedThing co-translational protein modification The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome. got7fsn_ti co-translational modification|cotranslational protein modification|cotranslational modification|cotranslational amino acid modification|co-translational amino acid modification This term should only be used to annotate a protein modification process that occurs after the start of translation but while the protein is still on the ribosome. biological_process owl:Class
GO:0006069 biolink:NamedThing ethanol oxidation An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. got7fsn_ti biological_process owl:Class
GO:0006067 biolink:NamedThing ethanol metabolic process The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. got7fsn_ti ethanol metabolism biological_process owl:Class
GO:0035777 biolink:NamedThing pronephric distal tubule development The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. got7fsn_ti bf 2011-04-04T11:06:01Z biological_process owl:Class
GO:0039020 biolink:NamedThing pronephric nephron tubule development The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct. got7fsn_ti bf 2010-07-02T10:11:36Z biological_process owl:Class
GO:0071161 biolink:NamedThing cyanophycin synthetase activity (L-arginine-adding) Catalysis of the reaction: ATP + [L-Asp(4-L-Arg)]n-L-Asp + L-arginine = ADP + phosphate + [L-Asp(4-L-Arg)]n+1. got7fsn_ti mah 2009-11-17T05:19:54Z EC:6.3.2.30|RHEA:23888 molecular_function owl:Class
GO:0060874 biolink:NamedThing posterior semicircular canal development The progession of the posterior semicircular canal from its initial formation to the mature structure. got7fsn_ti dph 2009-08-13T09:42:39Z biological_process owl:Class
GO:0002111 biolink:NamedThing BRCA2-BRAF35 complex A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis. got7fsn_ti cellular_component owl:Class
GO:0036385 biolink:NamedThing nucleoid DNA packaging Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid. got7fsn_ti bf 2013-05-30T10:36:05Z biological_process owl:Class
GO:0006323 biolink:NamedThing DNA packaging Any process in which DNA and associated proteins are formed into a compact, orderly structure. got7fsn_ti DNA organisation|DNA condensation|DNA organization biological_process owl:Class
GO:0005606 biolink:NamedThing laminin-1 complex A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains. got7fsn_ti laminin-111 complex cellular_component owl:Class
GO:0035725 biolink:NamedThing sodium ion transmembrane transport A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti sodium ion membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2011-03-10T02:52:36Z biological_process owl:Class
GO:0006814 biolink:NamedThing sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti mitochondrial sodium/calcium ion exchange|sodium channel auxiliary protein activity|sodium/potassium transport|sodium:solute transport|sodium:calcium exchange|sodium transport GO:0006834|GO:0016974 biological_process owl:Class
GO:2000039 biolink:NamedThing regulation of trichome morphogenesis Any process that modulates the frequency, rate or extent of trichome morphogenesis. got7fsn_ti regulation of trichome cell morphogenesis during differentiation tb 2010-08-05T11:36:31Z biological_process owl:Class
GO:2000024 biolink:NamedThing regulation of leaf development Any process that modulates the frequency, rate or extent of leaf development. got7fsn_ti tb 2010-08-05T11:25:14Z biological_process owl:Class
GO:0090737 biolink:NamedThing telomere maintenance via telomere trimming A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication. got7fsn_ti tb 2017-02-07T16:51:24Z biological_process owl:Class
GO:0005885 biolink:NamedThing Arp2/3 protein complex A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. got7fsn_ti cellular_component owl:Class
GO:0032010 biolink:NamedThing phagolysosome A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes. got7fsn_ti late phagosome|late phagocytic vesicle Wikipedia:Phagolysosome cellular_component owl:Class
GO:0036074 biolink:NamedThing metaplastic ossification Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division. got7fsn_ti metaplasia Some intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. bf 2011-12-19T01:50:35Z biological_process owl:Class
GO:0036072 biolink:NamedThing direct ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues. got7fsn_ti bf 2011-12-19T01:47:22Z biological_process owl:Class
GO:0102388 biolink:NamedThing UDP-N,N'-diacetylbacillosamine 2-epimerase activity Catalysis of the reaction: UDP-N,N'-diacetylbacillosamine + H2O <=> 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + UDP + H+. got7fsn_ti RHEA:34491|MetaCyc:RXN-13574|EC:3.2.1.184 molecular_function owl:Class
GO:0030957 biolink:NamedThing Tat protein binding Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. got7fsn_ti molecular_function owl:Class
GO:0060884 biolink:NamedThing clearance of cells from fusion plate The morphogenetic process in which cells are removed from the inner loop of a semicircular canal. got7fsn_ti dph 2009-08-13T12:25:59Z biological_process owl:Class
GO:0140025 biolink:NamedThing contractile vacuole tethering involved in discharge The initial, indirect interaction between a contractile vacuole membrane and a site of discharge in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. got7fsn_ti contractile vacuole tethering to plasma membrane pg 2017-05-02T09:50:10Z biological_process owl:Class
GO:0106325 biolink:NamedThing acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP. got7fsn_ti hjd 2020-09-30T13:37:55Z EC:2.4.1.148|RHEA:56188 molecular_function owl:Class
GO:0047225 biolink:NamedThing acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R + UDP. got7fsn_ti uridine diphosphoacetylglucosamine-mucin beta(1->6)-acetylglucosaminyltransferase B|O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity|core 4 beta6-GalNAc-transferase activity|core 6beta-GalNAc-transferase B|UDP-N-acetyl-D-glucosamine:O-oligosaccharide-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity|core 6-beta-GalNAc-transferase B activity MetaCyc:2.4.1.148-RXN|RHEA:16552|EC:2.4.1.148 molecular_function owl:Class
GO:0034565 biolink:NamedThing 1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity Catalysis of the reaction: 1-nitro-1,2-dihydro-1,3,5-triazine + 2 H2O = 1-nitro-1,3,5-triazinane-2,4-diol. got7fsn_ti EC:3.5.99.-|UM-BBD_reactionID:r0872 molecular_function owl:Class
GO:0003314 biolink:NamedThing heart rudiment morphogenesis The process in which the anatomical structures of the heart rudiment are generated and organized. got7fsn_ti heart cone morphogenesis dph 2009-10-27T08:38:04Z biological_process owl:Class
GO:0035585 biolink:NamedThing calcium-mediated signaling using extracellular calcium source A series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response. got7fsn_ti extracellular calcium influx|calcium signaling using extracellular calcium source|calcium-mediated signalling using extracellular calcium source|calcium signalling using extracellular calcium source bf 2010-10-18T11:04:27Z biological_process owl:Class
GO:0051841 biolink:NamedThing positive regulation by host of cytolysis of symbiont cells Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti stimulation by host of cytolysis of symbiont cells|up-regulation by host of cytolysis of symbiont cells|upregulation by host of cytolysis of symbiont cells|activation by host of cytolysis of symbiont cells|up regulation by host of cytolysis of symbiont cells biological_process owl:Class
GO:0051839 biolink:NamedThing regulation by host of cytolysis of symbiont cells Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0034464 biolink:NamedThing BBSome A ciliary protein complex involved in cilium biogenesis. It consists of at least seven Bardet-Biedl syndrome (BBS) proteins and BBIP10. It moves in association with IFT trains through cilia (likely as an IFT-A/B adaptor or cargo), and is required for the integrity of IFT-A and IFT-B. got7fsn_ti Bardet-Biedl syndrome complex cellular_component owl:Class
GO:0050727 biolink:NamedThing regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. got7fsn_ti biological_process owl:Class
GO:0140064 biolink:NamedThing peptide crotonyltransferase activity Catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide. got7fsn_ti protein crotonyltransferase activity pg 2017-07-20T16:40:57Z molecular_function owl:Class
GO:0072055 biolink:NamedThing renal cortex development The process whose specific outcome is the progression of the renal cortex over time, from its formation to the mature structure. The renal cortex is the outer region of the kidney. got7fsn_ti mah 2010-01-25T04:01:12Z biological_process owl:Class
GO:0097664 biolink:NamedThing SCF-Grr1/Pof2 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Grr1 in S. cerevisiae (Pof2 in S. pombe). got7fsn_ti pr 2014-10-06T10:27:10Z cellular_component owl:Class
GO:1990226 biolink:NamedThing histone methyltransferase binding Binding to a histone methyltransferase enzyme. got7fsn_ti pr 2013-11-07T11:59:58Z molecular_function owl:Class
GO:0033885 biolink:NamedThing 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity Catalysis of the reaction: (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate. got7fsn_ti (9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity|lipid-phosphate phosphatase activity|hydroxy lipid phosphatase activity|hydroxy fatty acid phosphatase activity|soluble epoxide hydrolase activity|sEH|(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate phosphohydrolase activity|dihydroxy fatty acid phosphatase activity KEGG_REACTION:R07582|EC:3.1.3.76|RHEA:16537|MetaCyc:3.1.3.76-RXN molecular_function owl:Class
GO:0047057 biolink:NamedThing vitamin-K-epoxide reductase (warfarin-sensitive) activity Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues. got7fsn_ti vitamin K1 epoxide reductase activity|phylloquinone epoxide reductase activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.1.4.1. Reactome:R-HSA-6806647|RHEA:57744|Reactome:R-HSA-159790|EC:1.17.4.4|MetaCyc:1.1.4.1-RXN molecular_function owl:Class
GO:0016900 biolink:NamedThing oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule. got7fsn_ti oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor EC:1.1.4.- molecular_function owl:Class
GO:0004638 biolink:NamedThing phosphoribosylaminoimidazole carboxylase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2). got7fsn_ti ADE2|1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity|5-phosphoribosyl-5-aminoimidazole carboxylase activity|5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity|AIR carboxylase activity|5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]|class II PurE|5-amino-1-ribosylimidazole 5-phosphate carboxylase activity KEGG_REACTION:R04209|EC:4.1.1.21|MetaCyc:AIRCARBOXY-RXN|Reactome:R-HSA-73806|RHEA:10792 molecular_function owl:Class
GO:0035122 biolink:NamedThing embryonic medial fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming. got7fsn_ti embryonic unpaired fin morphogenesis biological_process owl:Class
GO:0070693 biolink:NamedThing P-TEFb-cap methyltransferase complex A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping methyltransferase. got7fsn_ti P-TEFb-Pcm1 complex|Cdk9-Pcm1 complex mah 2009-06-04T02:38:58Z cellular_component owl:Class
GO:0002451 biolink:NamedThing peripheral B cell tolerance induction Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue. got7fsn_ti peripheral B lymphocyte tolerance induction|peripheral B-lymphocyte tolerance induction|peripheral B-cell tolerance induction biological_process owl:Class
GO:0000323 biolink:NamedThing lytic vacuole A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases. got7fsn_ti cellular_component owl:Class
GO:0045200 biolink:NamedThing establishment of neuroblast polarity The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system. got7fsn_ti establishment of neuroblast cell polarity GO:0043340|GO:0043343 biological_process owl:Class
GO:0030010 biolink:NamedThing establishment of cell polarity The specification and formation of anisotropic intracellular organization or cell growth patterns. got7fsn_ti bud site selection/establishment of cell polarity|cell polarization GO:0030468|GO:0000283 biological_process owl:Class
GO:0019379 biolink:NamedThing sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8). got7fsn_ti sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin) MetaCyc:SO4ASSIM-PWY biological_process owl:Class
GO:0000103 biolink:NamedThing sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. got7fsn_ti sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor|sulphate assimilation|sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor GO:0019378 biological_process owl:Class
GO:0044325 biolink:NamedThing transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. got7fsn_ti ion channel binding https://github.com/geneontology/go-ontology/issues/21331 jl 2010-08-04T12:52:59Z molecular_function owl:Class
GO:0042267 biolink:NamedThing natural killer cell mediated cytotoxicity The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. got7fsn_ti NK cell mediated cell death|natural killer-cell mediated cytolysis|NK cell mediated cell killing|natural killer cell mediated cytolysis|natural killer cell mediated cell death|natural killer cell mediated cell killing|killer activity|NK cell mediated cytotoxicity|NK cell mediated cytolysis Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. biological_process owl:Class
GO:0001909 biolink:NamedThing leukocyte mediated cytotoxicity The directed killing of a target cell by a leukocyte. got7fsn_ti immune cell mediated cell death|leucocyte mediated cytotoxicity|immune cell mediated cytotoxicity|immune cell mediated cell killing Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. biological_process owl:Class
GO:0061286 biolink:NamedThing mesonephric capsule morphogenesis The process in which the anatomical structures of the mesonephric capsule are generated and organized. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. got7fsn_ti dph 2010-09-02T01:53:31Z biological_process owl:Class
GO:0072128 biolink:NamedThing renal capsule morphogenesis The process in which the anatomical structures of the renal capsule are generated and organized. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. got7fsn_ti mah 2010-02-22T02:06:19Z biological_process owl:Class
GO:0051255 biolink:NamedThing spindle midzone assembly The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap. got7fsn_ti spindle midzone biogenesis|spindle midzone formation|spindle midzone biosynthesis biological_process owl:Class
GO:0007593 biolink:NamedThing chitin-based cuticle sclerotization The process of hardening of a chitin-based cuticle. got7fsn_ti cuticle hardening|chitin-based cuticle tanning GO:0045452 biological_process owl:Class
GO:0007591 biolink:NamedThing molting cycle, chitin-based cuticle The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster. got7fsn_ti chitin-based cuticle molting cycle biological_process owl:Class
GO:0020031 biolink:NamedThing polar ring of apical complex An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite. got7fsn_ti anterior polar ring of apical complex|upper polar ring of apical complex cellular_component owl:Class
GO:0050358 biolink:NamedThing tropinone reductase activity Catalysis of the reaction: NADP(+) + pseudotropine = H(+) + NADPH + tropinone. got7fsn_ti tropinone (psi-tropine-forming) reductase activity|pseudotropine forming tropinone reductase activity|pseudotropine:NADP+ 3-oxidoreductase activity|tropinone reductase II activity KEGG_REACTION:R06734|EC:1.1.1.236|RHEA:24244|MetaCyc:TROPINONE-REDUCTASE-RXN molecular_function owl:Class
GO:0042983 biolink:NamedThing amyloid precursor protein biosynthetic process The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. got7fsn_ti amyloid precursor protein formation|amyloid precursor protein anabolism|amyloid precursor protein synthesis|amyloid precursor protein biosynthesis|APP biosynthesis|APP biosynthetic process biological_process owl:Class
GO:0042982 biolink:NamedThing amyloid precursor protein metabolic process The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. got7fsn_ti APP metabolic process|amyloid precursor protein metabolism|APP metabolism biological_process owl:Class
GO:0019610 biolink:NamedThing 3-hydroxyphenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate. got7fsn_ti 3-hydroxyphenylacetate catabolism|3-hydroxyphenylacetate degradation|3-hydroxyphenylacetate breakdown MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY biological_process owl:Class
GO:0062014 biolink:NamedThing negative regulation of small molecule metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process. got7fsn_ti negative regulation of small molecule metabolism dph 2018-03-19T14:27:23Z biological_process owl:Class
GO:0009346 biolink:NamedThing ATP-independent citrate lyase complex Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity. This enzyme has only been found in bacteria. got7fsn_ti citrate synthase complex|citrate lyase complex https://github.com/geneontology/go-ontology/issues/21028 Note that this complex has only been found in bacteria. For eukaryotic cytrate lyases, consider GO:0140615 ; ATP-dependent citrate lyase complex. MetaCyc:ACECITLY-CPLX cellular_component owl:Class
GO:0098926 biolink:NamedThing postsynaptic signal transduction Signal transduction in which the initial step occurs in a postsynapse. got7fsn_ti postsynaptic signaling pathway Do not directly annotate. This term is intended for automatically grouping annotations to signal transduction classes extended with has_start_location/occurs_in postsynapse or one of its parts. biological_process owl:Class
GO:0097401 biolink:NamedThing synaptic vesicle lumen acidification The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading. got7fsn_ti synaptic vesicle proton loading|synaptic vesicle lumen pH reduction pr 2012-10-25T09:03:34Z biological_process owl:Class
GO:0038036 biolink:NamedThing sphingosine-1-phosphate receptor activity Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti S1P receptor activity bf 2011-10-28T03:46:54Z molecular_function owl:Class
GO:0031047 biolink:NamedThing gene silencing by RNA Any process in which RNA molecules inactivate expression of target genes. got7fsn_ti RNA-mediated gene silencing biological_process owl:Class
GO:0016458 biolink:NamedThing gene silencing Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression. got7fsn_ti This is a rather broad grouping term. While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class. Wikipedia:Gene_silencing biological_process owl:Class
GO:0008444 biolink:NamedThing CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+). got7fsn_ti phosphatidylglycerolphosphate synthase activity|CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity|CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity|3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity|CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity|phosphatidylglycerol phosphate synthase activity|glycerophosphate phosphatidyltransferase activity|CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity|PGP synthase activity|glycerol phosphate phosphatidyltransferase activity|cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity|glycerol 3-phosphate phosphatidyltransferase activity|CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity|sn-glycerol-3-phosphate phosphatidyltransferase activity|phosphatidylglycerophosphate synthetase activity|phosphatidylglycerol phosphate synthetase activity|phosphatidylglycerophosphate synthase activity Reactome:R-HSA-1482939|EC:2.7.8.5|KEGG_REACTION:R01801|MetaCyc:PHOSPHAGLYPSYN-RXN|RHEA:12593 molecular_function owl:Class
GO:0017169 biolink:NamedThing CDP-alcohol phosphatidyltransferase activity Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. got7fsn_ti molecular_function owl:Class
GO:0021878 biolink:NamedThing forebrain astrocyte fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain. got7fsn_ti biological_process owl:Class
GO:0060018 biolink:NamedThing astrocyte fate commitment The commitment of a cells to a specific astrocyte fate and its restriction to develop only into an astrocyte. got7fsn_ti biological_process owl:Class
GO:0050270 biolink:NamedThing S-adenosylhomocysteine deaminase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H(2)O + H(+) = S-inosyl-L-homocysteine + NH(4)(+). got7fsn_ti adenosylhomocysteine deaminase activity|S-adenosyl-L-homocysteine aminohydrolase activity RHEA:20716|EC:3.5.4.28|MetaCyc:S-ADENOSYLHOMOCYSTEINE-DEAMINASE-RXN|KEGG_REACTION:R00193 molecular_function owl:Class
GO:0102665 biolink:NamedThing indole-3-acetyl-glutamate synthetase activity Catalysis of the reaction: indole-3-acetate + L-glutamate + ATP <=> H+ + indole-3-acetyl-glutamate + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-2947 molecular_function owl:Class
GO:0050965 biolink:NamedThing detection of temperature stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal. got7fsn_ti sensory perception of pain, sensory detection of thermal stimulus|sensory transduction of temperature stimulus during perception of pain|perception of pain, detection of temperature stimulus|sensory detection of thermal stimulus during sensory perception of pain|sensory transduction of thermal stimulus during sensory perception of pain|sensory detection of temperature stimulus during perception of pain|thermal nociception|perception of pain, sensory transduction of temperature stimulus|perception of pain, sensory detection of temperature stimulus|sensory perception of pain, sensory transduction of thermal stimulus biological_process owl:Class
GO:0043084 biolink:NamedThing penile erection The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. got7fsn_ti Wikipedia:Erection#Penile_erection biological_process owl:Class
GO:0003052 biolink:NamedThing circadian regulation of systemic arterial blood pressure Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours. got7fsn_ti biological_process owl:Class
GO:0032422 biolink:NamedThing purine-rich negative regulatory element binding Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes. got7fsn_ti PNR element binding molecular_function owl:Class
GO:0070264 biolink:NamedThing transcription factor TFIIIE complex A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIE contains a specific subset of ribosomal proteins. got7fsn_ti cellular_component owl:Class
GO:0102612 biolink:NamedThing syn-pimaradiene 6beta-hydroxylase activity Catalysis of the reaction: 9beta-pimara-7,15-diene + NADPH + O2 + H+ <=> 6beta-hydroxy-syn-pimaradiene + NADP + H2O. got7fsn_ti MetaCyc:RXN-15452 molecular_function owl:Class
GO:0016905 biolink:NamedThing myosin heavy chain kinase activity Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate. got7fsn_ti myosin heavy-chain kinase activity|ATP:myosin heavy-chain O-phosphotransferase activity|myosin-heavy-chain kinase activity|STK6|myosin II heavy chain kinase activity|myosin I heavy chain kinase activity|myosin I heavy-chain kinase activity|MHCK|myosin heavy chain kinase A activity|calmodulin-dependent myosin heavy chain kinase activity|myosin II heavy-chain kinase activity|MIHC kinase activity|ATP:myosin-heavy-chain O-phosphotransferase activity RHEA:11424|EC:2.7.11.7 molecular_function owl:Class
GO:0018940 biolink:NamedThing orcinol metabolic process The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants. got7fsn_ti orcin metabolic process|orcinol metabolism|orcin metabolism MetaCyc:P342-PWY|UM-BBD_pathwayID:orc biological_process owl:Class
GO:0035628 biolink:NamedThing cystic duct development The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct. got7fsn_ti bf 2010-12-10T01:24:28Z biological_process owl:Class
GO:0015592 biolink:NamedThing methylgalactoside transmembrane transporter activity Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. got7fsn_ti galactose/glucose (methylgalactoside) porter activity molecular_function owl:Class
GO:0034002 biolink:NamedThing (R)-limonene synthase activity Catalysis of the reaction: geranyl diphosphate = (4R)-limonene + diphosphate. got7fsn_ti (+)-limonene synthase activity|geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-(4R)-limonene-forming] activity|geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity EC:4.2.3.20|KEGG_REACTION:R06120|MetaCyc:4.2.3.20-RXN|RHEA:10940 molecular_function owl:Class
GO:0009442 biolink:NamedThing allantoin assimilation pathway The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP. got7fsn_ti allantoin catabolism via ureidoglycolate|allantoin degradation pathway|allantoin catabolic process via ureidoglycolate MetaCyc:PWY0-41 biological_process owl:Class
GO:0000256 biolink:NamedThing allantoin catabolic process The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea. got7fsn_ti allantoin degradation|allantoin breakdown|allantoin catabolism biological_process owl:Class
GO:0018544 biolink:NamedThing 4-carboxy-4'-sulfoazobenzene reductase activity Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate. got7fsn_ti 4-carboxy-4'-sulphoazobenzene reductase activity UM-BBD_reactionID:r0543 molecular_function owl:Class
GO:0048795 biolink:NamedThing swim bladder morphogenesis The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. got7fsn_ti gas bladder morphogenesis biological_process owl:Class
GO:0099536 biolink:NamedThing synaptic signaling Cell-cell signaling to, from or within a synapse. got7fsn_ti biological_process owl:Class
GO:0008730 biolink:NamedThing L(+)-tartrate dehydratase activity Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate. got7fsn_ti L-tartrate dehydratase activity|tartrate dehydratase activity|(R,R)-tartrate hydro-lyase activity|L-(+)-tartaric acid dehydratase activity|tartaric acid dehydrase activity|(R,R)-tartrate hydro-lyase (oxaloacetate-forming) MetaCyc:LTARTDEHYDRA-RXN|EC:4.2.1.32|RHEA:15413|KEGG_REACTION:R00339 molecular_function owl:Class
GO:0086003 biolink:NamedThing cardiac muscle cell contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell. got7fsn_ti tb 2011-11-10T07:48:15Z biological_process owl:Class
GO:0050115 biolink:NamedThing myosin-light-chain-phosphatase activity Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate. got7fsn_ti myosin-light-chain-phosphate phosphohydrolase activity|[Myosin light-chain]-phosphatase activity|protein phosphatase 2A|myosin light-chain kinase phosphatase activity|myosin light chain kinase phosphatase activity|myosin-light-chain phosphatase activity EC:3.1.3.53|Reactome:R-HSA-419232|MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN molecular_function owl:Class
GO:0015558 biolink:NamedThing secondary active p-aminobenzoyl-glutamate transmembrane transporter activity Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid. got7fsn_ti p-aminobenzoyl-glutamate uptake transmembrane transporter activity|p-aminobenzoyl-glutamate uptake permease activity|p-aminobenzoyl-glutamate transporter activity|p-aminobenzoyl-glutamate transmembrane transporter activity GO:0015569 molecular_function owl:Class
GO:0070842 biolink:NamedThing aggresome assembly The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein. got7fsn_ti mah 2009-07-31T01:30:25Z biological_process owl:Class
GO:0070841 biolink:NamedThing inclusion body assembly The aggregation, arrangement and bonding together of a set of components to form an inclusion body. got7fsn_ti mah 2009-07-31T01:28:14Z biological_process owl:Class
GO:0008237 biolink:NamedThing metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. got7fsn_ti metalloprotease activity|metalloproteinase activity Reactome:R-HSA-5211405|Reactome:R-HSA-5211356|Reactome:R-HSA-5211391|Reactome:R-HSA-2220976|Reactome:R-HSA-2666278|Reactome:R-HSA-2022399|Reactome:R-HSA-157632|Reactome:R-HSA-2022396|Reactome:R-HSA-2022368|Reactome:R-HSA-5211340|Reactome:R-HSA-9013284|Reactome:R-HSA-2022393|Reactome:R-HSA-8986181|Reactome:R-HSA-9604264|Reactome:R-HSA-9662837|Reactome:R-HSA-193679|Reactome:R-HSA-2730752|Reactome:R-HSA-157629|Reactome:R-HSA-2220944|Reactome:R-HSA-3928660|Reactome:R-HSA-5211387|Reactome:R-HSA-5211400 molecular_function owl:Class
GO:0098800 biolink:NamedThing inner mitochondrial membrane protein complex Any protein complex that is part of the inner mitochondrial membrane. got7fsn_ti cellular_component owl:Class
GO:0043720 biolink:NamedThing 3-keto-5-aminohexanoate cleavage activity Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate. got7fsn_ti 3-keto-5-aminohexanoate cleavage enzyme RHEA:31555|MetaCyc:R125-RXN molecular_function owl:Class
GO:0098788 biolink:NamedThing dendritic knob The terminal swelling of an apical dendrite of a ciliated olfactory receptor neuron. Each knob gives rise to 5 to 20 long delicate nonmotile cilia, which extend into the mucus covering the sensory epithelium. got7fsn_ti apical dendritic knob cellular_component owl:Class
GO:0051230 biolink:NamedThing spindle disassembly The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. got7fsn_ti spindle catabolism|spindle breakdown|spindle degradation biological_process owl:Class
GO:0018261 biolink:NamedThing peptidyl-lysine guanylylation The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine. got7fsn_ti RESID:AA0228 biological_process owl:Class
GO:0018260 biolink:NamedThing protein guanylylation The addition of phospho-guanosine to a protein amino acid. got7fsn_ti protein amino acid guanylylation biological_process owl:Class
GO:0009729 biolink:NamedThing detection of brassinosteroid stimulus The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of brassinosteroid stimulus biological_process owl:Class
GO:0009741 biolink:NamedThing response to brassinosteroid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. got7fsn_ti response to brassinosteroid stimulus biological_process owl:Class
GO:0106239 biolink:NamedThing 9,13-epoxylabda-14-ene synthase activity Catalysis of the reaction:peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate. got7fsn_ti hjd 2019-12-19T16:00:49Z EC:4.2.3.189|RHEA:54512 molecular_function owl:Class
GO:0010558 biolink:NamedThing negative regulation of macromolecule biosynthetic process Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biological_process owl:Class
GO:0035891 biolink:NamedThing exit from host cell The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ejection from host cell|host cell exit bf 2011-06-15T02:09:28Z biological_process owl:Class
GO:0031249 biolink:NamedThing denatured protein binding Binding to a denatured protein. got7fsn_ti Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates. molecular_function owl:Class
GO:1990253 biolink:NamedThing cellular response to leucine starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine. got7fsn_ti al 2013-12-10T11:55:10Z biological_process owl:Class
GO:0099121 biolink:NamedThing fungal sorus development The process whose specific outcome is the progression of a fungal sorus over time, from its formation to the mature structure. A fungal sorus is a spore containing structure. got7fsn_ti biological_process owl:Class
GO:0004883 biolink:NamedThing glucocorticoid receptor activity Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function. got7fsn_ti molecular_function owl:Class
GO:0003707 biolink:NamedThing steroid hormone receptor activity Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. got7fsn_ti Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: nuclear receptor activity ; GO:0004879' or nuclear receptor transcription coactivator activity ; GO:0030374'. molecular_function owl:Class
GO:0010617 biolink:NamedThing circadian regulation of calcium ion oscillation Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours. got7fsn_ti circadian regulation of cytosolic calcium ion homeostasis|circadian regulation of [Ca2+]cyt oscillation|circadian regulation of Ca2+ oscillation|circadian regulation of cytosolic free calcium ion oscillation biological_process owl:Class
GO:0071005 biolink:NamedThing U2-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. got7fsn_ti mammalian U2-type spliceosomal complex B1|mammalian U2-type spliceosomal complex B|yeast U12-type spliceosomal complex A2-1|GT-AG precatalytic spliceosome|major precatalytic spliceosome mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0061742 biolink:NamedThing chaperone-mediated autophagy translocation complex A lysosomal membrane protein complex that enables the translocation of a target protein across the lysosomal membrane as part of chaperone-mediated autophagy. got7fsn_ti CMA translocation complex|CMA receptor complex|chaperone-mediated autophagy receptor complex https://github.com/geneontology/go-ontology/issues/20850 dph 2015-10-23T07:39:04Z cellular_component owl:Class
GO:0044858 biolink:NamedThing plasma membrane raft polarization The clustering and aggregation of a plasma membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. got7fsn_ti plasma membrane polarization jl 2014-07-23T16:21:39Z biological_process owl:Class
GO:0061471 biolink:NamedThing karyomere assembly The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle. got7fsn_ti dph 2012-11-02T09:13:59Z biological_process owl:Class
GO:0010605 biolink:NamedThing negative regulation of macromolecule metabolic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti biological_process owl:Class
GO:0018649 biolink:NamedThing tetrahydrofuran hydroxylase activity Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran. got7fsn_ti EC:1.14.13.-|UM-BBD_reactionID:r0017 molecular_function owl:Class
GO:1900603 biolink:NamedThing tensidol A metabolic process The chemical reactions and pathways involving tensidol A. got7fsn_ti tensidol A metabolism di 2012-05-15T06:57:47Z biological_process owl:Class
GO:0005483 biolink:NamedThing soluble NSF attachment protein activity Binding to both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex. got7fsn_ti SNAP https://github.com/geneontology/go-ontology/issues/16807 molecular_function owl:Class
GO:0010324 biolink:NamedThing membrane invagination The infolding of a membrane. got7fsn_ti single-organism membrane invagination jl 2013-12-02T13:58:34Z GO:1902534 biological_process owl:Class
GO:0044242 biolink:NamedThing cellular lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells. got7fsn_ti cellular lipid catabolism|cellular lipid degradation|cellular lipid breakdown biological_process owl:Class
GO:0047552 biolink:NamedThing 2-oxoaldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: a 2-oxoaldehyde + NADP+ + H2O = a 2-oxo acid + NADPH + H+. got7fsn_ti 2-oxoaldehyde:NADP+ 2-oxidoreductase activity|NADP-dependent alpha-ketoaldehyde dehydrogenase activity|2-ketoaldehyde dehydrogenase|alpha-ketoaldehyde dehydrogenase activity|methylglyoxal dehydrogenase activity|NADP-linked alpha-ketoaldehyde dehydrogenase activity RHEA:18129|MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NADP+-RXN|EC:1.2.1.49 molecular_function owl:Class
GO:0033781 biolink:NamedThing cholesterol 24-hydroxylase activity Catalysis of the reaction: cholesterol + H(+) + NADPH + O(2) = (24S)-24-hydroxycholesterol + H(2)O + NADP(+). got7fsn_ti cholesterol 24S-hydroxylase activity|cytochrome P450 46A1|CYP46A1|cholesterol 24-monooxygenase activity|cholesterol,NADPH:oxygen oxidoreductase (24-hydroxylating) activity|CYP46 EC:1.14.14.25|Reactome:R-HSA-192061|KEGG_REACTION:R07207|RHEA:22716|MetaCyc:1.14.13.98-RXN molecular_function owl:Class
GO:0038030 biolink:NamedThing non-canonical Wnt signaling pathway via MAPK cascade The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the MAPKKK cascade. got7fsn_ti non-canonical Wnt-activated signaling pathway via MAPK cascade|non-canonical Wnt receptor signaling pathway via MAPK signaling|non-canonical Wnt receptor signaling pathway via MAPKKK cascade|non-canonical Wnt receptor signaling pathway via MAPK cascade|non-canonical Wnt receptor signalling pathway via MAPKKK cascade bf 2011-09-08T01:46:07Z biological_process owl:Class
GO:0061264 biolink:NamedThing mesonephric glomerular mesangial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular mesangial cell. got7fsn_ti dph 2010-08-30T02:59:11Z biological_process owl:Class
GO:0018050 biolink:NamedThing C-terminal peptidyl-threonine amidation The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0097 biological_process owl:Class
GO:0035921 biolink:NamedThing desmosome disassembly The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. got7fsn_ti desmosome dissociation bf 2011-07-05T01:33:25Z biological_process owl:Class
GO:0022411 biolink:NamedThing cellular component disassembly A cellular process that results in the breakdown of a cellular component. got7fsn_ti cell structure disassembly|cellular component disassembly at cellular level GO:0071845 biological_process owl:Class
GO:0061472 biolink:NamedThing karyomere membrane fusion Process whereby karyomere membranes fuse during interphase to form a single lobed nucleus. got7fsn_ti dph 2012-11-02T09:25:41Z biological_process owl:Class
GO:0106123 biolink:NamedThing reservosome A large membrane-bound endocytic organelle present only in members of the Schizotrypanum subgenus of the Trypanosoma genus and is defined as the site of storage of endocytosed macromolecules and lysosomal enzymes. It is found at the posterior end of epimastigote forms of Trypanosoma cruzi, but absent in amastigotes and trypomastigotes. got7fsn_ti hjd 2018-05-03T17:48:59Z cellular_component owl:Class
GO:0021982 biolink:NamedThing pineal gland development The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms. got7fsn_ti epiphysis development biological_process owl:Class
GO:0018215 biolink:NamedThing protein phosphopantetheinylation The modification of a protein amino acid by phosphopantetheinylation. got7fsn_ti protein amino acid phosphopantetheinylation biological_process owl:Class
GO:1903430 biolink:NamedThing negative regulation of cell maturation Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation. got7fsn_ti negative regulation of functional differentiation|inhibition of cell maturation|downregulation of cell maturation|down-regulation of functional differentiation|downregulation of functional differentiation|inhibition of functional differentiation|down regulation of cell maturation|down regulation of functional differentiation|down-regulation of cell maturation jl 2014-09-15T13:31:32Z biological_process owl:Class
GO:0089720 biolink:NamedThing caspase binding Binding to a caspase family protein. got7fsn_ti molecular_function owl:Class
GO:0002020 biolink:NamedThing protease binding Binding to a protease or a peptidase. got7fsn_ti Reactome:R-HSA-1297354 molecular_function owl:Class
GO:0008476 biolink:NamedThing protein-tyrosine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate. got7fsn_ti protein-tyrosine sulphotransferase activity|tyrosylprotein sulfotransferase activity|3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity Reactome:R-HSA-9668148|Reactome:R-HSA-9668023|MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN|EC:2.8.2.20|Reactome:R-HSA-8954262|RHEA:16801 molecular_function owl:Class
GO:2000383 biolink:NamedThing regulation of ectoderm development Any process that modulates the frequency, rate or extent of ectoderm development. got7fsn_ti vk 2011-02-15T03:17:10Z biological_process owl:Class
GO:0072210 biolink:NamedThing metanephric nephron development The process whose specific outcome is the progression of a nephron in the metanephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. got7fsn_ti mah 2010-03-18T12:52:57Z biological_process owl:Class
GO:0004392 biolink:NamedThing heme oxygenase (decyclizing) activity Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]. got7fsn_ti heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)|heme oxidase activity|haem oxygenase activity|heme oxygenase activity|haem oxidase activity|haem oxygenase (decyclizing) activity|ORP33 proteins https://github.com/geneontology/go-ontology/issues/21106 MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN|EC:1.14.14.18|RHEA:21764|Reactome:R-HSA-189398 molecular_function owl:Class
GO:0018154 biolink:NamedThing peptide cross-linking via (2R,6R)-lanthionine The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine). got7fsn_ti RESID:AA0110 biological_process owl:Class
GO:0102431 biolink:NamedThing acyl-lipid omega-(9-4) desaturase Catalysis of the reaction: linoleoyl-[glycerolipid] + 2 ferrocytochrome b5 + O2 + 2 H(+) <=> pinolenoyl-[glycerolipid] + 2 ferricytochrome b5 + 2 H2O. got7fsn_ti linoleate delta5 desaturase activity MetaCyc:RXN-13858|EC:1.14.19.12|RHEA:46236 molecular_function owl:Class
GO:0046020 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter by pheromones Any process involving pheromones that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. got7fsn_ti negative regulation of transcription from Pol II promoter by pheromones|down regulation of transcription from RNA polymerase II promoter by pheromones|downregulation of transcription from RNA polymerase II promoter by pheromones|inhibition of transcription from RNA polymerase II promoter by pheromones|down-regulation of transcription from RNA polymerase II promoter by pheromones biological_process owl:Class
GO:0045996 biolink:NamedThing negative regulation of transcription by pheromones Any process involving pheromones that stops, prevents or reduces the rate of transcription. got7fsn_ti down regulation of transcription by pheromones|down-regulation of transcription by pheromones|downregulation of transcription by pheromones|inhibition of transcription by pheromones biological_process owl:Class
GO:0006536 biolink:NamedThing glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. got7fsn_ti glutamic acid metabolic process|glutamate metabolism|glutamic acid metabolism Wikipedia:Glutamic_acid biological_process owl:Class
GO:0070664 biolink:NamedThing negative regulation of leukocyte proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation. got7fsn_ti downregulation of leukocyte proliferation|inhibition of leukocyte proliferation|down regulation of leukocyte proliferation|down-regulation of leukocyte proliferation mah 2009-05-28T05:34:50Z biological_process owl:Class
GO:0072325 biolink:NamedThing vulval cell fate commitment The process in which the cellular identity of nematode vulval cells is acquired and determined. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. got7fsn_ti mah 2010-11-01T02:02:16Z biological_process owl:Class
GO:0120045 biolink:NamedThing stereocilium maintenance The organization process that preserves a stereocilium in a stable functional or structural state. got7fsn_ti krc 2017-05-15T20:55:13Z biological_process owl:Class
GO:0009866 biolink:NamedThing induced systemic resistance, ethylene mediated signaling pathway The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance. got7fsn_ti induced systemic resistance, ethylene mediated signalling pathway|induced systemic resistance, ethene mediated signaling pathway|ethene mediated signaling pathway (induced systemic resistance)|induced systemic resistance, ethene mediated signalling pathway|ethylene mediated signaling pathway (induced systemic resistance) biological_process owl:Class
GO:0004612 biolink:NamedThing phosphoenolpyruvate carboxykinase (ATP) activity Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate. got7fsn_ti PEPCK (ATP)|ATP:oxaloacetate carboxy-lyase (transphosphorylating)|ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)|phosphopyruvate carboxylase (ATP)|phosphopyruvate carboxykinase|phosphopyruvate carboxykinase (adenosine triphosphate)|phosphoenolpyruvate carboxylase (ATP)|phosphoenolpyruvic carboxykinase|PEPK EC:4.1.1.49|RHEA:18617|MetaCyc:PEPCARBOXYKIN-RXN|KEGG_REACTION:R00341 molecular_function owl:Class
GO:0071541 biolink:NamedThing eukaryotic translation initiation factor 3 complex, eIF3m An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. got7fsn_ti eIF3m-containing eukaryotic translation initiation factor 3 complex mah 2010-01-12T02:26:41Z cellular_component owl:Class
GO:0062189 biolink:NamedThing anandamide 14,15 epoxidase activity Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(14,15-epoxy-5Z,8Z,11Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti dph 2019-11-26T18:57:55Z RHEA:53148 molecular_function owl:Class
GO:0102685 biolink:NamedThing UDP-glucose:trans-zeatin 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + trans-zeatin <=> H+ + trans-zeatin-7-N-glucoside + UDP. got7fsn_ti MetaCyc:RXN-4721 molecular_function owl:Class
GO:0030104 biolink:NamedThing water homeostasis Any process involved in the maintenance of an internal steady state of water within an organism or cell. got7fsn_ti regulation of osmotic pressure|osmoregulation GO:0018987 Wikipedia:Osmoregulation biological_process owl:Class
GO:0030628 biolink:NamedThing pre-mRNA 3'-splice site binding Binding to a pre-mRNA 3' splice site sequence. got7fsn_ti pre-mRNA 3' splice site binding molecular_function owl:Class
GO:0070379 biolink:NamedThing high mobility group box 1 binding Binding to high mobility group box 1 (HMBGB1). got7fsn_ti HMGB1 binding molecular_function owl:Class
GO:0006515 biolink:NamedThing protein quality control for misfolded or incompletely synthesized proteins The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins. got7fsn_ti protein quality control by the ubiquitin-proteasome system|misfolded or incompletely synthesized protein breakdown|misfolded or incompletely synthesized protein degradation|degradation of misfolded or incompletely synthesized proteins|protein quality control (PQC)|misfolded or incompletely synthesized protein catabolism|misfolded or incompletely synthesized protein catabolic process biological_process owl:Class
GO:0021557 biolink:NamedThing oculomotor nerve development The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. got7fsn_ti CN III development|cranial nerve 3 development|cranial nerve III development biological_process owl:Class
GO:0060820 biolink:NamedThing inactivation of X chromosome by heterochromatin assembly Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by the mechanism of heterochromatin formation. got7fsn_ti inactivation of X chromosome by heterochromatin formation dph 2009-08-11T10:58:06Z biological_process owl:Class
GO:0035575 biolink:NamedThing histone H4-methyl-lysine-20 demethylase activity Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone demethylase activity (H4-K20 specific)|histone H4K20me demethylase activity https://github.com/geneontology/go-ontology/issues/21089 bf 2010-08-13T10:51:13Z Reactome:R-HSA-2172678 molecular_function owl:Class
GO:0007290 biolink:NamedThing spermatid nucleus elongation The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation. got7fsn_ti spermatid nuclear elongation biological_process owl:Class
GO:0008823 biolink:NamedThing cupric reductase activity Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH. got7fsn_ti EC:1.16.1.-|MetaCyc:R170-RXN molecular_function owl:Class
GO:0018834 biolink:NamedThing dichloromethane dehalogenase activity Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+). got7fsn_ti dichloromethane chloride-lyase (chloride-hydrolysing)|dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming) RHEA:15397|KEGG_REACTION:R00603|UM-BBD_reactionID:r0188|MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN|EC:4.5.1.3 molecular_function owl:Class
GO:0018104 biolink:NamedThing peptidoglycan-protein cross-linking The process of covalently linking peptidoglycan (murein) to proteins. got7fsn_ti biological_process owl:Class
GO:0009373 biolink:NamedThing regulation of transcription by pheromones Any process involving pheromones that modulates the frequency, rate or extent of transcription. got7fsn_ti biological_process owl:Class
GO:0047127 biolink:NamedThing thiomorpholine-carboxylate dehydrogenase activity Catalysis of the reaction: NAD(P)+ + thiomorpholine-3-carboxylate = NAD(P)H + 3,4-dehydro-1,4-thiomorpholine-3-carboxylate. got7fsn_ti ketimine-reducing enzyme|thiomorpholine-3-carboxylate:NAD(P)+ 5,6-oxidoreductase activity|ketimine reductase activity Reactome:R-HSA-5693347|MetaCyc:1.5.1.25-RXN|EC:1.5.1.25 molecular_function owl:Class
GO:0034663 biolink:NamedThing endoplasmic reticulum chaperone complex A protein complex that is located in the endoplasmic reticulum and is composed of chaperone proteins, including BiP, GRP94; CaBP1, protein disulfide isomerase (PDI), ERdj3, cyclophilin B, ERp72, GRP170, UDP-glucosyltransferase, and SDF2-L1. got7fsn_ti ER chaperone complex|endoplasmic reticulum network complex|ER network complex cellular_component owl:Class
GO:0042252 biolink:NamedThing establishment of planar polarity of larval imaginal disc epithelium Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates. got7fsn_ti biological_process owl:Class
GO:0070024 biolink:NamedThing CD19-Vav-PIK3R1 complex A protein complex that contains the cell surface signaling molecule CD19, the Ras guanine nucleotide exchange factor Vav, and the regulatory subunit alpha of phosphatidylinositol 3-kinase (PI3K). got7fsn_ti CD19-Vav-PI 3-kinase (p85 subunit) complex cellular_component owl:Class
GO:0046601 biolink:NamedThing positive regulation of centriole replication Any process that activates or increases the frequency, rate or extent of centriole replication. got7fsn_ti up regulation of centriole replication|up-regulation of centriole replication|activation of centriole replication|upregulation of centriole replication|stimulation of centriole replication biological_process owl:Class
GO:0031078 biolink:NamedThing histone deacetylase activity (H3-K14 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein. got7fsn_ti molecular_function owl:Class
GO:0046529 biolink:NamedThing imaginal disc fusion, thorax closure The joining of the parts of the wing imaginal discs, giving rise to the adult thorax. got7fsn_ti biological_process owl:Class
GO:0030070 biolink:NamedThing insulin processing The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges. got7fsn_ti biological_process owl:Class
GO:0008734 biolink:NamedThing L-aspartate oxidase activity Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide. got7fsn_ti L-aspartate:oxygen oxidoreductase RHEA:25876|EC:1.4.3.16|MetaCyc:L-ASPARTATE-OXID-RXN|MetaCyc:RXN-9772 molecular_function owl:Class
GO:0031754 biolink:NamedThing Edg-1 sphingosine 1-phosphate receptor binding Binding to an Edg-1 sphingosine 1-phosphate receptor. got7fsn_ti Edg-1 sphingosine 1-phosphate receptor ligand molecular_function owl:Class
GO:1990938 biolink:NamedThing peptidyl-aspartic acid autophosphorylation The phosphorylation by a protein of one or more of its own aspartate amino acid residues, or an aspartate residue on an identical protein. got7fsn_ti aspartyl autophosphorylation|peptidyl-aspartate autophosphorylation bf 2016-04-04T10:49:53Z biological_process owl:Class
GO:0033931 biolink:NamedThing endogalactosaminidase activity Catalysis of the endohydrolysis of (1->4)-alpha-D-galactosaminidic linkages in poly(D-galactosamine). got7fsn_ti galactosaminoglycan glycanohydrolase activity MetaCyc:3.2.1.109-RXN|EC:3.2.1.109 molecular_function owl:Class
GO:0071353 biolink:NamedThing cellular response to interleukin-4 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus. got7fsn_ti cellular response to IL-4 mah 2009-12-11T02:51:00Z biological_process owl:Class
GO:0008784 biolink:NamedThing alanine racemase activity Catalysis of the reaction: L-alanine = D-alanine. got7fsn_ti L-alanine racemase activity RHEA:20249|MetaCyc:ALARACECAT-RXN|KEGG_REACTION:R00401|EC:5.1.1.1 molecular_function owl:Class
GO:0009738 biolink:NamedThing abscisic acid-activated signaling pathway A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription. got7fsn_ti ABA signal transduction|abscisic acid signal transduction|ABA signaling|abscisic acid mediated signalling|abscisic acid-mediated signaling pathway biological_process owl:Class
GO:0001877 biolink:NamedThing lipoarabinomannan immune receptor activity Combining with lipoarabinomannan and transmitting the signal to initiate an innate immune response. got7fsn_ti LAM receptor activity|lipoarabinomannan receptor activity molecular_function owl:Class
GO:1990891 biolink:NamedThing mitotic sister chromatid arm separation The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis. got7fsn_ti mah 2015-11-03T14:01:16Z biological_process owl:Class
GO:1903047 biolink:NamedThing mitotic cell cycle process A process that is part of the mitotic cell cycle. got7fsn_ti jl 2014-05-22T14:22:34Z biological_process owl:Class
GO:0006543 biolink:NamedThing glutamine catabolic process The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid. got7fsn_ti glutamine breakdown|glutamine degradation|glutamine catabolism biological_process owl:Class
GO:0014852 biolink:NamedThing regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system. got7fsn_ti biological_process owl:Class
GO:0033169 biolink:NamedThing histone H3-K9 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone. got7fsn_ti biological_process owl:Class
GO:0070076 biolink:NamedThing histone lysine demethylation The modification of a histone by the removal of a methyl group from a lysine residue. got7fsn_ti biological_process owl:Class
GO:0001002 biolink:NamedThing RNA polymerase III type 1 promoter sequence-specific DNA binding Binding to a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition. got7fsn_ti RNA polymerase III type 1 promoter DNA binding krc 2010-08-18T05:38:20Z GO:0001030 molecular_function owl:Class
GO:0080084 biolink:NamedThing 5S rDNA binding Binding to a 5S rDNA sequence, encoding ribosomal 5S rRNA, which is individually transcribed by RNA polymerase III, rather than by RNA polymerase I, in species where it exists. got7fsn_ti dhl 2009-04-22T02:32:20Z molecular_function owl:Class
GO:0097562 biolink:NamedThing left lateral basal body pair Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally. got7fsn_ti Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T16:09:11Z cellular_component owl:Class
GO:0007516 biolink:NamedThing hemocyte development The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. got7fsn_ti arthropod blood cell development biological_process owl:Class
GO:0042019 biolink:NamedThing interleukin-23 binding Binding to interleukin-23. got7fsn_ti IL-23 binding molecular_function owl:Class
GO:0010337 biolink:NamedThing regulation of salicylic acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid. got7fsn_ti regulation of salicylic acid metabolism biological_process owl:Class
GO:0030075 biolink:NamedThing bacterial thylakoid A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria. got7fsn_ti plasma membrane-derived thylakoid cellular_component owl:Class
GO:0009579 biolink:NamedThing thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. got7fsn_ti photosynthetic membrane A thylakoid is not considered an organelle, but some thylakoids are part of organelles. Wikipedia:Thylakoid cellular_component owl:Class
GO:0044195 biolink:NamedThing nucleoplasmic reticulum Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport. got7fsn_ti nuclear channels jl 2009-10-20T02:24:09Z cellular_component owl:Class
GO:0019604 biolink:NamedThing toluene oxidation to catechol The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2). got7fsn_ti UM-BBD_pathwayID:tol|MetaCyc:TOLUENE-DEG-CATECHOL-PWY biological_process owl:Class
GO:0120303 biolink:NamedThing visually-mediated background adaptation Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by melanopsin-expressing eye cells. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20524 krc 2021-02-09T18:35:11Z biological_process owl:Class
GO:0120302 biolink:NamedThing background adaptation Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20524 krc 2021-02-09T18:11:11Z biological_process owl:Class
GO:0048389 biolink:NamedThing intermediate mesoderm development The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. got7fsn_ti biological_process owl:Class
GO:0001949 biolink:NamedThing sebaceous gland cell differentiation The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell. got7fsn_ti sebocytes differentiation biological_process owl:Class
GO:0052628 biolink:NamedThing 4-hydroxybenzoate amino acid synthetase activity Catalysis of the reaction: 4-hydroxybenzoate + ATP + amino acid = 4-hydroxybenzoyl amino acid conjugate + AMP + diphosphate. got7fsn_ti 4-hydroxybenzoyl amino acid synthetase activity|p-hydroxybenzoyl amino acid synthetase activity|p-hydroxybenzoate amino acid synthetase activity|4HBA amino acid synthetase activity molecular_function owl:Class
GO:0102379 biolink:NamedThing steviolbioside glucosyltransferase activity (stevioside forming) Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = stevioside + UDP + H+. got7fsn_ti MetaCyc:RXN-13514 molecular_function owl:Class
GO:0101004 biolink:NamedThing cytolytic granule membrane The lipid bilayer surrounding the cytolytic granule. got7fsn_ti mec 2015-12-15T04:32:00Z cellular_component owl:Class
GO:0005765 biolink:NamedThing lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. got7fsn_ti lysosome membrane cellular_component owl:Class
GO:0014734 biolink:NamedThing skeletal muscle hypertrophy The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils. got7fsn_ti biological_process owl:Class
GO:0043501 biolink:NamedThing skeletal muscle adaptation Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals. got7fsn_ti skeletal muscle plasticity biological_process owl:Class
GO:0018428 biolink:NamedThing copper incorporation into copper-sulfur cluster The incorporation of copper into a copper-sulfur cluster. got7fsn_ti copper incorporation into copper-sulphur cluster biological_process owl:Class
GO:0000818 biolink:NamedThing nuclear MIS12/MIND complex A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1. got7fsn_ti Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex|MIND complex cellular_component owl:Class
GO:0000104 biolink:NamedThing succinate dehydrogenase activity Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor. got7fsn_ti succinic acid dehydrogenase activity|fumarate reductase activity|succinic dehydrogenase activity|succinate oxidoreductase activity|succinate:(acceptor) oxidoreductase activity|succinate:acceptor oxidoreductase activity|fumaric hydrogenase activity|succinyl dehydrogenase activity|fumarate dehydrogenase activity|succinodehydrogenase activity GO:0019739 RHEA:16357|MetaCyc:SUCC-FUM-OXRED-RXN molecular_function owl:Class
GO:0120139 biolink:NamedThing positive regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Any process that activates or increases the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. got7fsn_ti krc 2018-03-22T16:24:20Z biological_process owl:Class
GO:0050572 biolink:NamedThing L-idonate 5-dehydrogenase activity Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+. got7fsn_ti L-idonate:NAD(P)+ oxidoreductase activity MetaCyc:1.1.1.264-RXN|EC:1.1.1.264 molecular_function owl:Class
GO:0035605 biolink:NamedThing peptidyl-cysteine S-nitrosylase activity Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein. got7fsn_ti protein nitrosylase activity|S-nitrosylase activity This term should not be used to annotate the nitrosylating action of nitric oxide synthase (NOS) if the nitroso group is synthesized directly on the substrate. bf 2010-11-16T09:49:26Z molecular_function owl:Class
GO:0001823 biolink:NamedThing mesonephros development The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney. got7fsn_ti Wolffian body development biological_process owl:Class
GO:0016493 biolink:NamedThing C-C chemokine receptor activity Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. got7fsn_ti molecular_function owl:Class
GO:0004950 biolink:NamedThing chemokine receptor activity Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. got7fsn_ti molecular_function owl:Class
GO:0034495 biolink:NamedThing protein storage vacuole lumen The volume enclosed by the protein storage vacuole membrane. got7fsn_ti cellular_component owl:Class
GO:0035137 biolink:NamedThing hindlimb morphogenesis The process in which the anatomical structures of the hindlimb are generated and organized. got7fsn_ti biological_process owl:Class
GO:0051920 biolink:NamedThing peroxiredoxin activity Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. got7fsn_ti Prx activity|alkyl hydroperoxide reductase C22 activity|PRDX activity|AhpC activity|thiol-containing-reductant:hydroperoxide oxidoreductase activity Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism. Reactome:R-HSA-1222431|EC:1.11.1.24|Reactome:R-HSA-1222755|Reactome:R-HSA-1500804|RHEA:10008|MetaCyc:1.11.1.15-RXN molecular_function owl:Class
GO:0018439 biolink:NamedThing peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester. got7fsn_ti peptidyl-leucine esterification GO:0018440 RESID:AA0299 biological_process owl:Class
GO:0033756 biolink:NamedThing Oplophorus-luciferin 2-monooxygenase activity Catalysis of the reaction: Oplophorus luciferin + O2 = oxidized Oplophorus luciferin + CO2 + hnu. got7fsn_ti Oplophorus-luciferin:oxygen 2-oxidoreductase (decarboxylating) activity|Oplophorus luciferase activity RHEA:20417|MetaCyc:RXN-3361|EC:1.13.12.13 molecular_function owl:Class
GO:0016997 biolink:NamedThing alpha-sialidase activity Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. got7fsn_ti molecular_function owl:Class
GO:0098747 biolink:NamedThing slow, calcium ion-dependent exocytosis of neurotransmitter The slow, second phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on high affinity calcium sensors and decays slowly, typically with a decay constant of over 100ms. The underlying molecular mechanisms of this process are distinct from those of the earlier, fast phase of release. got7fsn_ti biological_process owl:Class
GO:0048791 biolink:NamedThing calcium ion-regulated exocytosis of neurotransmitter The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. got7fsn_ti biological_process owl:Class
GO:0002629 biolink:NamedThing negative regulation of proteolysis associated with antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation. got7fsn_ti downregulation of proteolysis associated with antigen processing and presentation|down regulation of proteolysis associated with antigen processing and presentation|down-regulation of proteolysis associated with antigen processing and presentation|inhibition of proteolysis associated with antigen processing and presentation biological_process owl:Class
GO:0047581 biolink:NamedThing 4-methyleneglutamate-ammonia ligase activity Catalysis of the reaction: 4-methylene-L-glutamate + ATP + NH(4)(+) = 4-methylene-L-glutamine + AMP + diphosphate + 2 H(+). got7fsn_ti 4-methyleneglutamine synthetase activity|4-methylene-L-glutamate:ammonia ligase (AMP-forming) EC:6.3.1.7|RHEA:13853|KEGG_REACTION:R02711|MetaCyc:4-METHYLENEGLUTAMATE--AMMONIA-LIGASE-RXN molecular_function owl:Class
GO:0018068 biolink:NamedThing peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases. got7fsn_ti peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine|peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine|peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine RESID:AA0147 biological_process owl:Class
GO:0060959 biolink:NamedThing cardiac neuron development The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state. got7fsn_ti heart neuron development dph 2009-09-30T10:14:56Z biological_process owl:Class
GO:0034325 biolink:NamedThing O-decanoyltransferase activity Catalysis of the transfer of a decyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0034563 biolink:NamedThing 2,3-bis(4-hydroxyphenyl)-1,2-propanediol dioxygenase activity Catalysis of the reaction: 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + O2 = 4-hydroxyphenacyl alcohol + 4-hydroxybenzoate + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0867 molecular_function owl:Class
GO:0097194 biolink:NamedThing execution phase of apoptosis A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. got7fsn_ti execution phase of apoptotic process|apoptosis pr 2011-11-23T09:45:24Z biological_process owl:Class
GO:0009353 biolink:NamedThing mitochondrial oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus. got7fsn_ti See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. cellular_component owl:Class
GO:0036052 biolink:NamedThing protein localization to uropod A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell. got7fsn_ti protein localisation to uropod bf 2011-12-12T10:45:26Z biological_process owl:Class
GO:0042338 biolink:NamedThing cuticle development involved in collagen and cuticulin-based cuticle molting cycle Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans. got7fsn_ti collagen and cuticulin-based cuticle development during molting|cuticle anabolism during molting|cuticle biosynthetic process during molting|cuticle formation during molting|cuticle synthesis during molting biological_process owl:Class
GO:0070314 biolink:NamedThing G1 to G0 transition A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence. got7fsn_ti cell cycle quiescence|G1/G0 transition|stationary phase|establishment of cell quiescence biological_process owl:Class
GO:0042106 biolink:NamedThing gamma-delta T cell receptor complex A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein. got7fsn_ti gamma-delta TCR complex|gamma-delta T-lymphocyte receptor complex|gamma-delta T-cell receptor complex|gamma-delta T lymphocyte receptor complex cellular_component owl:Class
GO:0042101 biolink:NamedThing T cell receptor complex A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. got7fsn_ti TCR complex|T-lymphocyte receptor complex|TCR|T-cell receptor complex|T lymphocyte receptor complex Wikipedia:T_cell_receptor cellular_component owl:Class
GO:0036034 biolink:NamedThing mediator complex assembly The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. got7fsn_ti bf 2011-10-31T05:18:11Z biological_process owl:Class
GO:0102229 biolink:NamedThing amylopectin maltohydrolase activity Catalysis of the reaction: n H2O + an exposed unphosphorylated, unbranched malto-oligosaccharide tail on amylopectin <=> amylopectin + maltose. got7fsn_ti EC:3.2.1.2|MetaCyc:RXN-12278 molecular_function owl:Class
GO:0016062 biolink:NamedThing adaptation of rhodopsin mediated signaling The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation. got7fsn_ti adaptation of rhodopsin mediated signalling biological_process owl:Class
GO:0047441 biolink:NamedThing 5-dehydro-2-deoxyphosphogluconate aldolase activity Catalysis of the reaction: 6-phospho-5-dehydro-2-deoxy-D-gluconate = 3-oxopropanoate + glycerone phosphate. got7fsn_ti 5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase (pyruvate-forming)|phospho-5-dehydro-2-deoxygluconate aldolase activity|phospho-5-keto-2-deoxygluconate aldolase activity|5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity RHEA:13177|MetaCyc:4.1.2.29-RXN|EC:4.1.2.29|KEGG_REACTION:R05378 molecular_function owl:Class
GO:0071632 biolink:NamedThing optomotor response Eye, head or whole body movements that help to compensate movements of the environment in order to stabilize its image on the retina. In the case of whole body movements, these motor actions may also stabilize a locomotor course in response to some disturbance. Examples include: the optokinetic reflex, which allows human eyes to follow objects in motion while the head remains stationary reflex; the optomotor responses of flying insects and swimming fish. got7fsn_ti mah 2010-02-11T04:06:41Z Wikipedia:Optomotor_response biological_process owl:Class
GO:0007634 biolink:NamedThing optokinetic behavior The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus. got7fsn_ti optokinetic behaviour biological_process owl:Class
GO:0008131 biolink:NamedThing primary amine oxidase activity Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. got7fsn_ti primary-amine:oxygen oxidoreductase (deaminating) activity|amine oxidase (copper-containing) activity|amine oxidase activity GO:0008122|GO:0004041 Reactome:R-HSA-5696146|Reactome:R-HSA-141202|KEGG_REACTION:R01853|Reactome:R-HSA-5696183|Reactome:R-HSA-379382|EC:1.4.3.21|Reactome:R-HSA-379395|MetaCyc:RXN-9597|Reactome:R-HSA-141200|Reactome:R-HSA-5603108|Reactome:R-HSA-141186|Reactome:R-HSA-374909 molecular_function owl:Class
GO:0018268 biolink:NamedThing GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine|GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine RESID:AA0161 biological_process owl:Class
GO:0002554 biolink:NamedThing serotonin secretion by platelet The regulated release of serotonin by a platelet or group of platelets. got7fsn_ti serotonin release by platelet biological_process owl:Class
GO:0120297 biolink:NamedThing histone dopaminyltransferase activity Catalysis of the reaction: dopamine + L-glutaminyl-[histone] = 5-dopaminyl-L-glutamyl-[histone] + NH4(+). got7fsn_ti https://github.com/geneontology/go-ontology/issues/20685 krc 2021-01-19T03:17:13Z molecular_function owl:Class
GO:0120296 biolink:NamedThing peptide dopaminyltransferase activity Catalysis of the reaction: dopamine + L-glutaminyl-[protein] = 5-dopaminyl-L-glutamyl-[protein] + NH4(+). got7fsn_ti https://github.com/geneontology/go-ontology/issues/20685 krc 2021-01-19T02:20:30Z RHEA:66556 molecular_function owl:Class
GO:0018080 biolink:NamedThing peptidyl-tryptophan bromination The bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan. got7fsn_ti RESID:AA0179 biological_process owl:Class
GO:0051434 biolink:NamedThing BH3 domain binding Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. got7fsn_ti molecular_function owl:Class
GO:0017008 biolink:NamedThing protein-phycobiliviolin linkage The linkage of the chromophore phycobiliviolin to phycoerythrocyanin. got7fsn_ti RESID:AA0258 biological_process owl:Class
GO:0052673 biolink:NamedThing prenol kinase activity Catalysis of the reaction: prenol + nucleoside triphosphate = prenyl phosphate + nucleoside diphosphate activity. got7fsn_ti prenol phosphotransferase activity|prenyl alcohol kinase activity|prenyl alcohol phosphotransferase activity ai 2011-04-11T04:02:23Z molecular_function owl:Class
GO:0003053 biolink:NamedThing circadian regulation of heart rate Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours. got7fsn_ti circadian regulation of heart contraction rate biological_process owl:Class
GO:0010459 biolink:NamedThing negative regulation of heart rate Any process that stops, prevents or reduces the frequency or rate of heart contraction. got7fsn_ti biological_process owl:Class
GO:2000847 biolink:NamedThing negative regulation of corticosteroid hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of corticosteroid hormone secretion. got7fsn_ti negative regulation of corticosteroid secretion bf 2011-07-26T08:43:42Z biological_process owl:Class
GO:0039650 biolink:NamedThing suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process. got7fsn_ti inhibition of host caspases by virus bf 2012-10-09T15:30:48Z biological_process owl:Class
GO:0019050 biolink:NamedThing suppression by virus of host apoptotic process Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication. got7fsn_ti suppression of apoptosis in host by virus|negative regulation by virus of host apoptosis|negative regulation of apoptosis by virus|suppression by virus of host apoptosis biological_process owl:Class
GO:0030263 biolink:NamedThing apoptotic chromosome condensation The compaction of chromatin during apoptosis. got7fsn_ti pyknosis Wikipedia:Pyknosis biological_process owl:Class
GO:0030261 biolink:NamedThing chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. got7fsn_ti eukaryotic chromosome condensation|DNA condensation|nuclear chromosome condensation GO:0000068 biological_process owl:Class
GO:0045106 biolink:NamedThing intermediate filament depolymerization Disassembly of intermediate filaments by the removal of component monomers from a filament. got7fsn_ti biological_process owl:Class
GO:0071570 biolink:NamedThing cement gland development The process whose specific outcome is the progression of the cement gland over time, from its formation to the mature structure. The cement gland is a simple mucus-secreting organ positioned at the anterior of amphibious embryos. The cement gland attaches the newly hatched embryo to a support before the hatchling can swim well or feed. got7fsn_ti mah 2010-01-20T04:31:04Z biological_process owl:Class
GO:0003169 biolink:NamedThing coronary vein morphogenesis The process in which the anatomical structures of veins of the heart are generated and organized. got7fsn_ti dph 2009-10-08T10:45:41Z biological_process owl:Class
GO:0039642 biolink:NamedThing virion nucleoid The region of a virion in which the nucleic acid is confined. got7fsn_ti bf 2012-09-07T14:14:52Z cellular_component owl:Class
GO:0060578 biolink:NamedThing superior vena cava morphogenesis The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart. got7fsn_ti dph 2009-05-06T08:47:21Z biological_process owl:Class
GO:0030435 biolink:NamedThing sporulation resulting in formation of a cellular spore The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. got7fsn_ti spore formation|spore biosynthesis|cellular spore formation by sporulation|spore differentiation Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. Wikipedia:Sporogenesis biological_process owl:Class
GO:0010813 biolink:NamedThing neuropeptide catabolic process The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction. got7fsn_ti biological_process owl:Class
GO:0102307 biolink:NamedThing erythromycin C 3''-o-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + erythromycin C <=> S-adenosyl-L-homocysteine + erythromycin A + H+. got7fsn_ti RHEA:32647|EC:2.1.1.254|MetaCyc:RXN-12923 molecular_function owl:Class
GO:0002222 biolink:NamedThing stimulatory killer cell immunoglobulin-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation. got7fsn_ti stimulatory KIR signaling pathway|stimulatory killer cell immunoglobulin-like receptor signalling pathway biological_process owl:Class
GO:0002220 biolink:NamedThing innate immune response activating cell surface receptor signaling pathway Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor. got7fsn_ti innate immune response activating cell surface receptor signalling pathway|activation of innate immune response by cell surface receptor signaling pathway biological_process owl:Class
GO:0015284 biolink:NamedThing fructose uniporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in). got7fsn_ti molecular_function owl:Class
GO:0045148 biolink:NamedThing tripeptide aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a tripeptide. got7fsn_ti peptidase B|imidoendopeptidase activity|peptidase T|lymphopeptidase activity|aminotripeptidase activity|alanine-phenylalanine-proline arylamidase activity|aminoexotripeptidase activity https://github.com/geneontology/go-ontology/issues/19681 MetaCyc:3.4.11.4-RXN|EC:3.4.11.4 molecular_function owl:Class
GO:0004177 biolink:NamedThing aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 MetaCyc:3.4.11.5-RXN|Reactome:R-HSA-983162|EC:3.4.11.5|EC:3.4.11.-|EC:3.4.11.9|EC:3.4.11.21|MetaCyc:3.4.11.21-RXN|MetaCyc:3.4.11.6-RXN|MetaCyc:3.4.11.9-RXN|EC:3.4.11.6|MetaCyc:RXN0-5052|Reactome:R-HSA-2534096|Reactome:R-HSA-8851929|Reactome:R-HSA-1236954 molecular_function owl:Class
GO:0102151 biolink:NamedThing 3-oxo-myristate decarboxylase activity Catalysis of the reaction: 3-oxo-myristate + H+ <=> 2-tridecanone + carbon dioxide. got7fsn_ti MetaCyc:RXN-11669|EC:4.1.1.56 molecular_function owl:Class
GO:0006034 biolink:NamedThing cuticle chitin metabolic process The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. got7fsn_ti cuticle chitin metabolism biological_process owl:Class
GO:0006030 biolink:NamedThing chitin metabolic process The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. got7fsn_ti chitin metabolism|beta-1,4-linked N-acetylglucosamine metabolic process|beta-1,4-linked N-acetylglucosamine metabolism biological_process owl:Class
GO:0005685 biolink:NamedThing U1 snRNP A ribonucleoprotein complex that contains small nuclear RNA U1, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U1 snRNP, most of which remain associated with the U1 snRNA both while the U1 snRNP is free or assembled into a series of spliceosomal complexes. got7fsn_ti snRNP U1 cellular_component owl:Class
GO:0047630 biolink:NamedThing ADP-phosphoglycerate phosphatase activity Catalysis of the reaction: 3-ADP-2-phosphoglycerate + H(2)O = 3-ADP-glycerate + phosphate. got7fsn_ti ADPphosphoglycerate phosphatase activity|3-(ADP)-2-phosphoglycerate phosphohydrolase activity|adenosine diphosphate phosphoglycerate phosphatase activity RHEA:15861|KEGG_REACTION:R03969|MetaCyc:ADP-PHOSPHOGLYCERATE-PHOSPHATASE-RXN|EC:3.1.3.28 molecular_function owl:Class
GO:0005041 biolink:NamedThing low-density lipoprotein particle receptor activity Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis. got7fsn_ti LDL receptor|low-density lipoprotein receptor activity|LDLR activity GO:0008032 Reactome:R-HSA-2404131|Wikipedia:LDL_receptor|Reactome:R-HSA-2424254 molecular_function owl:Class
GO:0030228 biolink:NamedThing lipoprotein particle receptor activity Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. got7fsn_ti plasma lipoprotein particle receptor activity|lipoprotein receptor activity This term is intended for cell surface receptors that bind and internalize a lipoprotein particle. For members of the lipoprotein receptor family that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children, or 'reelin receptor activity ; GO:0038025'. molecular_function owl:Class
GO:0018582 biolink:NamedThing 1-hydroxy-2-naphthoate 1,2-dioxygenase activity Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate. got7fsn_ti 1-hydroxy-2-naphthoate-degrading enzyme activity|1-hydroxy-2-naphthoate dioxygenase activity|1-hydroxy-2-naphthoic acid dioxygenase activity|1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing) RHEA:14749|EC:1.13.11.38|UM-BBD_reactionID:r0486|MetaCyc:1.13.11.38-RXN molecular_function owl:Class
GO:0061431 biolink:NamedThing cellular response to methionine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus. got7fsn_ti dph 2012-02-07T10:27:01Z biological_process owl:Class
GO:0045015 biolink:NamedThing HDEL sequence binding Binding to a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. got7fsn_ti HDEL receptor activity molecular_function owl:Class
GO:0033897 biolink:NamedThing ribonuclease T2 activity Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. got7fsn_ti Escherichia coli ribonuclease I' ribonuclease PP2 activity|RNase II activity|RNAase CL activity|RNase T2 activity|ribonucleate 3'-oligonucleotide hydrolase activity|RNase M activity|ribonuclease (non-base specific) activity|ribonucleate nucleotido-2'-transferase (cyclizing) activity|acid ribonuclease activity|ribonnuclease (non-base specific) activity|base-non-specific ribonuclease activity|non-base specific ribonuclease activity|ribonuclease PP3 activity|ribonuclease N2 activity|ribonuclease II activity|ribonuclease U4 activity|nonspecific RNase activity|RNase Ms activity|RNase (non-base specific) activity|nonbase-specific RNase activity|acid RNase activity|ribonuclease M activity|Escherichia coli ribonuclease II activity EC:4.6.1.19|MetaCyc:3.1.27.1-RXN molecular_function owl:Class
GO:0098619 biolink:NamedThing selenocysteine-tRNA ligase activity Catalysis of the reaction: tRNASec + L-Ser + ATP = Ser-tRNASec + AMP + diphosphate. got7fsn_ti Reactome:R-HSA-2408526 molecular_function owl:Class
GO:0033055 biolink:NamedThing D-arginine metabolic process The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid. got7fsn_ti D-arginine metabolism biological_process owl:Class
GO:0005115 biolink:NamedThing receptor tyrosine kinase-like orphan receptor binding Binding to a receptor tyrosine kinase-like orphan receptor (Ror). got7fsn_ti Ror ligand|Ror binding|receptor tyrosine kinase-like orphan receptor ligand molecular_function owl:Class
GO:0102662 biolink:NamedThing malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity Catalysis of the reaction: 3-oxopropanoate + coenzyme A(4-) + NAD(1-) <=> acetyl-CoA(4-) + carbon dioxide + NADH(2-). got7fsn_ti RHEA:22992|MetaCyc:RXN-2902 molecular_function owl:Class
GO:0014024 biolink:NamedThing neural rod cavitation The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube. got7fsn_ti biological_process owl:Class
GO:0060605 biolink:NamedThing tube lumen cavitation The formation of a lumen by hollowing out a solid rod or cord. got7fsn_ti dph 2009-05-15T09:39:49Z biological_process owl:Class
GO:0050645 biolink:NamedThing limonoid glucosyltransferase activity Catalysis of the reaction: UDP-glucose + limonin = glucosyl-limonin + UDP. got7fsn_ti uridine diphosphoglucose-limonoid glucosyltransferase activity|LGTase activity|limonoid UDP-glucosyltransferase activity EC:2.4.1.210|RHEA:11256|MetaCyc:2.4.1.210-RXN molecular_function owl:Class
GO:0034910 biolink:NamedThing 6-hydroxy-3-succinoylpyridine hydrolase activity Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine. got7fsn_ti UM-BBD_reactionID:r1442 molecular_function owl:Class
GO:0001662 biolink:NamedThing behavioral fear response An acute behavioral change resulting from a perceived external threat. got7fsn_ti behavioural fear response biological_process owl:Class
GO:1990254 biolink:NamedThing keratin filament binding Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. got7fsn_ti tb 2013-12-13T22:05:25Z molecular_function owl:Class
GO:0075263 biolink:NamedThing oogonium development The process that leads to the development of an oogonium, a female gametangium of Oomycetes, containing one or more gametes. got7fsn_ti biological_process owl:Class
GO:0018417 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide RESID:AA0293 biological_process owl:Class
GO:0072238 biolink:NamedThing metanephric long nephron development The process whose specific outcome is the progression of a metanephric long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla in the metanephros. got7fsn_ti metanephric juxtamedullary nephron development mah 2010-03-18T03:48:23Z biological_process owl:Class
GO:0102719 biolink:NamedThing S-adenosyl-L-methionine:eugenol-O-methyltransferase activity Catalysis of the reaction: eugenol + S-adenosyl-L-methionine = H+ + O-methyleugenol + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.146|MetaCyc:RXN-6741 molecular_function owl:Class
GO:0052641 biolink:NamedThing benzoic acid glucosyltransferase activity Catalysis of the reaction: benzoic acid + UDP-glucose = benzoic acid glucose ester + UDP. got7fsn_ti UDP:glucose:benzoic acid glucosyltransferase activity|benzoate glucosyltransferase activity|UDP:glucose:BA glucosyltransferase activity|UDP:glucose:benzoate glucosyltransferase activity MetaCyc:RXN-11660 molecular_function owl:Class
GO:0004025 biolink:NamedThing alcohol dehydrogenase activity, iron-dependent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron. got7fsn_ti molecular_function owl:Class
GO:0004022 biolink:NamedThing alcohol dehydrogenase (NAD+) activity Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. got7fsn_ti aldehyde dehydrogenase (NAD) activity|yeast alcohol dehydrogenase|NAD-dependent alcohol dehydrogenase|aldo-keto reductase (NAD) activity|alcohol dehydrogenase activity|NADH-aldehyde dehydrogenase|alcohol:NAD+ oxidoreductase|ethanol dehydrogenase|NADH-alcohol dehydrogenase|aliphatic alcohol dehydrogenase|primary alcohol dehydrogenase|ADH|NAD-specific aromatic alcohol dehydrogenase EC:1.1.1.1|UM-BBD_enzymeID:e0023|Reactome:R-HSA-2162078|MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN|RHEA:10740 molecular_function owl:Class
GO:0071927 biolink:NamedThing octopamine signaling pathway The series of molecular signals generated as a consequence of octopamine binding to a cell surface receptor. got7fsn_ti octopamine signalling pathway mah 2010-09-28T01:18:57Z biological_process owl:Class
GO:0010162 biolink:NamedThing seed dormancy process A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors. got7fsn_ti seed dormancy Wikipedia:Seed#Seed_dormancy_and_protection biological_process owl:Class
GO:0044096 biolink:NamedThing type IV pilus A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers. got7fsn_ti TFP|type IV fimbriae|type 4 pilus jl 2009-04-22T02:52:55Z cellular_component owl:Class
GO:0047796 biolink:NamedThing cyclohexane-1,3-dione hydrolase activity Catalysis of the reaction: cyclohexane-1,3-dione + H(2)O = 5-oxohexanoate + H(+). got7fsn_ti cyclohexane-1,3-dione acylhydrolase (decyclizing)|1,3-cyclohexanedione hydrolase activity EC:3.7.1.10|MetaCyc:CYCLOHEXANE-13-DIONE-HYDROLASE-RXN|RHEA:16473|KEGG_REACTION:R03211 molecular_function owl:Class
GO:0061063 biolink:NamedThing positive regulation of nematode larval development Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. got7fsn_ti dph 2010-03-11T01:03:34Z biological_process owl:Class
GO:0061062 biolink:NamedThing regulation of nematode larval development Any process that modulates the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. got7fsn_ti dph 2010-03-11T12:59:21Z biological_process owl:Class
GO:0072188 biolink:NamedThing metanephric cap specification The process in which the metanephric cap acquires its identity. got7fsn_ti mah 2010-03-01T01:35:25Z biological_process owl:Class
GO:0072048 biolink:NamedThing renal system pattern specification Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate into the anatomical structures of the renal system. got7fsn_ti renal system pattern formation mah 2010-01-25T03:31:51Z biological_process owl:Class
GO:0044800 biolink:NamedThing multi-organism membrane fusion The membrane organization process that joins two lipid bilayers to form a single membrane, involving more than one organism. got7fsn_ti jl 2013-09-10T15:06:11Z biological_process owl:Class
GO:0018597 biolink:NamedThing ammonia monooxygenase activity Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions. got7fsn_ti EC:1.14.99.39|UM-BBD_enzymeID:e0061|RHEA:27341 molecular_function owl:Class
GO:0007441 biolink:NamedThing anterior midgut (ectodermal) morphogenesis The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized. got7fsn_ti biological_process owl:Class
GO:0038106 biolink:NamedThing choriogonadotropin hormone binding Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit. got7fsn_ti chorionic gonadotropin binding|chorionic gonadotrophin binding bf 2012-03-08T03:58:40Z molecular_function owl:Class
GO:0045992 biolink:NamedThing negative regulation of embryonic development Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development. got7fsn_ti down regulation of embryonic development|inhibition of embryonic development|down-regulation of embryonic development|downregulation of embryonic development biological_process owl:Class
GO:0046464 biolink:NamedThing acylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. got7fsn_ti acylglycerol catabolism|acylglycerol breakdown|acylglycerol degradation biological_process owl:Class
GO:0046461 biolink:NamedThing neutral lipid catabolic process The chemical reactions and pathways resulting in the breakdown of neutral lipids, lipids only soluble in solvents of very low polarity. got7fsn_ti neutral lipid degradation|neutral lipid breakdown|neutral lipid catabolism biological_process owl:Class
GO:0048505 biolink:NamedThing regulation of timing of cell differentiation The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development. got7fsn_ti timing of cell differentiation biological_process owl:Class
GO:0006617 biolink:NamedThing SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting. got7fsn_ti SRP-dependent cotranslational membrane targeting, signal sequence recognition|signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition biological_process owl:Class
GO:0034368 biolink:NamedThing protein-lipid complex remodeling The acquisition, loss or modification of a protein or lipid within a protein-lipid complex. got7fsn_ti biological_process owl:Class
GO:0060515 biolink:NamedThing prostate field specification The process that results in the delineation of a specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop. got7fsn_ti biological_process owl:Class
GO:0048576 biolink:NamedThing positive regulation of short-day photoperiodism, flowering Any process that activates, maintains or increases short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. got7fsn_ti up-regulation of short-day photoperiodism, flowering|activation of short-day photoperiodism, flowering|upregulation of short-day photoperiodism, flowering|stimulation of short-day photoperiodism, flowering|up regulation of short-day photoperiodism, flowering biological_process owl:Class
GO:0033748 biolink:NamedThing hydrogenase (acceptor) activity Catalysis of the reaction: H2 + A = AH2. got7fsn_ti hydrogen:acceptor oxidoreductase activity|hydrogenlyase activity|H2 producing hydrogenase activity|uptake hydrogenase activity|hydrogen:(acceptor) oxidoreductase activity|hydrogen-lyase activity RHEA:12116|MetaCyc:RXN0-4141|EC:1.12.99.6|MetaCyc:RXN0-5256 molecular_function owl:Class
GO:0047637 biolink:NamedThing alanylphosphatidylglycerol synthase activity Catalysis of the reaction: L-alanyl-tRNA + phosphatidylglycerol = tRNA + 3-O-L-alanyl-1-O-phosphatidylglycerol. got7fsn_ti L-alanyl-tRNA:phosphatidylglycerol alanyltransferase activity|alanyl phosphatidylglycerol synthetase activity|O-alanylphosphatidylglycerol synthase activity MetaCyc:ALANYLPHOSPHATIDYLGLYCEROL-SYNTHASE-RXN|RHEA:20489|EC:2.3.2.11 molecular_function owl:Class
GO:0086067 biolink:NamedThing AV node cell to bundle of His cell communication The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti atrioventricular node cell to bundle of His cell communication dph 2011-11-22T09:11:44Z biological_process owl:Class
GO:0090722 biolink:NamedThing receptor-receptor interaction The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function. got7fsn_ti hetero-receptor complex formation tb 2016-11-11T17:41:56Z molecular_function owl:Class
GO:0021622 biolink:NamedThing oculomotor nerve morphogenesis The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. got7fsn_ti CN III morphogenesis biological_process owl:Class
GO:1901597 biolink:NamedThing response to carbendazim Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus. got7fsn_ti mah 2012-11-07T17:17:06Z biological_process owl:Class
GO:1900768 biolink:NamedThing fonsecin catabolic process The chemical reactions and pathways resulting in the breakdown of fonsecin. got7fsn_ti fonsecin degradation|fonsecin breakdown|fonsecin catabolism di 2012-06-04T09:21:38Z biological_process owl:Class
GO:0102785 biolink:NamedThing violaxanthin oxygenase activity Catalysis of the reaction: violaxanthin + 2 O2 = 2 5,6-epoxy-3-hydroxy-9-apo-beta-caroten-9-one + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. got7fsn_ti MetaCyc:RXN-7886 molecular_function owl:Class
GO:0006962 biolink:NamedThing male-specific antibacterial humoral response An immune response against bacteria, specific to males and mediated through a body fluid. got7fsn_ti biological_process owl:Class
GO:0050831 biolink:NamedThing male-specific defense response to bacterium A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism. got7fsn_ti male-specific defence response to bacterium|male-specific defense response to bacteria|male-specific antibacterial peptide activity|male-specific defence response to bacteria biological_process owl:Class
GO:0051467 biolink:NamedThing detection of steroid hormone stimulus The series of events by which a steroid hormone stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0099508 biolink:NamedThing voltage-gated ion channel activity involved in regulation of presynaptic membrane potential Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. got7fsn_ti voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential|voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential|voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential|voltage gated ion channel activity involved in regulation of presynaptic membrane potential molecular_function owl:Class
GO:0005244 biolink:NamedThing voltage-gated ion channel activity Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-dependent ion channel activity|voltage gated ion channel activity molecular_function owl:Class
GO:0047766 biolink:NamedThing carbamoyl-serine ammonia-lyase activity Catalysis of the reaction: O-carbamoyl-L-serine + H(2)O + H(+) = CO(2) + 2 NH(4)(+) + pyruvate. got7fsn_ti O-carbamoyl-L-serine deaminase activity|carbamoylserine deaminase activity|O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming)|O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming) RHEA:15445|KEGG_REACTION:R00213|MetaCyc:CARBAMOYL-SERINE-AMMONIA-LYASE-RXN|EC:4.3.1.13 molecular_function owl:Class
GO:0003963 biolink:NamedThing RNA-3'-phosphate cyclase activity Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate. got7fsn_ti RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)|RNA 3'-terminal phosphate cyclase activity|RNA cyclase activity MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN|RHEA:23976|EC:6.5.1.4 molecular_function owl:Class
GO:0102591 biolink:NamedThing delphinidin 7-O-glucoside acyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-glucoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-(6-O-(p-hydroxybenzoyl)-glucoside) + beta-D-glucose. got7fsn_ti MetaCyc:RXN-15352 molecular_function owl:Class
GO:2000076 biolink:NamedThing positive regulation of cytokinesis, site selection Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis. got7fsn_ti positive regulation of site selection involved in cell cycle cytokinesis tb 2010-08-27T11:19:58Z biological_process owl:Class
GO:0032467 biolink:NamedThing positive regulation of cytokinesis Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. got7fsn_ti up-regulation of cytokinesis|upregulation of cytokinesis|positive regulation of cell cycle cytokinesis|stimulation of cytokinesis|activation of cytokinesis|up regulation of cytokinesis GO:0071777 biological_process owl:Class
GO:0032157 biolink:NamedThing prospore contractile ring A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis. got7fsn_ti meiotic contractile ring|cytokinetic ring|actomyosin ring cellular_component owl:Class
GO:0110086 biolink:NamedThing meiotic actomyosin contractile ring A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the meiotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the meiotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In fungal cells, the meiotic contractile ring forms beneath the plasma membrane of the prospore envelope in preparation for completing cytokinesis. got7fsn_ti kmv 2018-02-12T17:26:17Z cellular_component owl:Class
GO:0044016 biolink:NamedThing histone acetyltransferase activity (H3-K4 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K4 specific) molecular_function owl:Class
GO:0102199 biolink:NamedThing nitric oxide reductase activity (NAD(P)H-dependent) activity Catalysis of the reaction: dinitrogen oxide + H2O + NAD(P) = 2 nitric oxide + H+ + NAD(P)H. got7fsn_ti EC:1.7.1.14|MetaCyc:RXN-12112 molecular_function owl:Class
GO:0009014 biolink:NamedThing succinyl-diaminopimelate desuccinylase activity Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate. got7fsn_ti N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity|N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity RHEA:22608|MetaCyc:SUCCDIAMINOPIMDESUCC-RXN|EC:3.5.1.18|KEGG_REACTION:R02734 molecular_function owl:Class
GO:0016286 biolink:NamedThing small conductance calcium-activated potassium channel activity Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. got7fsn_ti SK KCa channels|small conductance KCa channels|SK calcium-activated potassium channel activity molecular_function owl:Class
GO:0060104 biolink:NamedThing surface coat of collagen and cuticulin-based cuticle extracellular matrix An electron dense, amorphous envelope that comprises the outermost layer of the cuticle. The surface coat is loosely apposed to the epicuticle, has distinct biochemical properties, is synthesized by cells other than the underlying hypodermis, and is labile. In addition to serving as a lubricant to protect against abrasion and dehydration, the surface coat may also play important roles in infection and immune evasion. An example of this component is found in Caenorhabditis elegans. got7fsn_ti surface coat of collagen and cuticulin-based exoskeleton extracellular matrix cellular_component owl:Class
GO:0080076 biolink:NamedThing caffeoyl CoA:S-adenosyl-L-methionine O-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a caffeoyl CoA molecule. got7fsn_ti dhl 2009-04-14T03:55:49Z molecular_function owl:Class
GO:1990001 biolink:NamedThing inhibition of cysteine-type endopeptidase activity involved in apoptotic process Any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process. got7fsn_ti pr 2012-12-05T15:42:50Z biological_process owl:Class
GO:0097340 biolink:NamedThing inhibition of cysteine-type endopeptidase activity Any process that prevents the activation of an inactive cysteine-type endopeptidase. got7fsn_ti inhibition of caspase activity|prevention of cysteine-type endopeptidase activity|prevention of caspase activity pr 2012-06-18T11:23:05Z biological_process owl:Class
GO:0019780 biolink:NamedThing FAT10 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti molecular_function owl:Class
GO:0004148 biolink:NamedThing dihydrolipoyl dehydrogenase activity Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. got7fsn_ti dehydrolipoate dehydrogenase activity|glycine-cleavage system L-protein activity|lipoamide oxidoreductase (NADH) activity|lipoamide dehydrogenase (NADH) activity|LDP-Val activity|protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase|lipoamide reductase (NADH) activity|dihydrothioctic dehydrogenase activity|dihydrolipoylprotein reduction|dihydrolipoamide dehydrogenase activity|protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase|lipoate dehydrogenase activity|lipoyl dehydrogenase activity|lipoamide reductase activity|dihydrolipoamide reduction|lipoic acid dehydrogenase activity|diaphorase activity|dihydrolipoamide:NAD+ oxidoreductase|LDP-Glc activity|L-protein activity|dihydrolipoic dehydrogenase activity|E3 component of alpha-ketoacid dehydrogenase complexes activity Reactome:R-HSA-5694018|MetaCyc:DIHYDLIPOXN-RXN|EC:1.8.1.4|RHEA:15045|Reactome:R-HSA-1222412 molecular_function owl:Class
GO:0046724 biolink:NamedThing oxalic acid secretion The controlled release of oxalic acid, ethanedioic acid, by a cell or a tissue. got7fsn_ti oxalate secretion biological_process owl:Class
GO:0061225 biolink:NamedThing mesonephric extraglomerular mesangial cell proliferation involved in mesonephros development The multiplication or reproduction of extraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa. got7fsn_ti mesonephric Goormaghtigh proliferation|mesonephric lacis cell proliferation dph 2010-08-19T01:34:59Z biological_process owl:Class
GO:0033998 biolink:NamedThing inulin fructotransferase (DFA-III-forming) activity Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride (DFA III) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide. got7fsn_ti inulin fructotransferase (depolymerizing, difructofuranose-1,2':2,3'-dianhydride-forming) activity|inulinase II activity|inulin D-fructosyl-D-fructosyltransferase (1,2':2,3'-dianhydride-forming) activity|inulin fructotransferase (depolymerizing) activity|inulin fructotransferase (DFA-III-producing) activity|inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,3'-dianhydride) activity|2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,3'-dianhydride-forming) activity|inulase II activity MetaCyc:4.2.2.18-RXN|EC:4.2.2.18 molecular_function owl:Class
GO:0009772 biolink:NamedThing photosynthetic electron transport in photosystem II A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. got7fsn_ti biological_process owl:Class
GO:0009767 biolink:NamedThing photosynthetic electron transport chain A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. got7fsn_ti photosynthetic electron transport in plastocyanin|photosynthetic electron transport in cytochrome b6/f|photosynthetic electron transport in plastoquinone|electron carrier, chlorophyll electron transport system GO:0009776|GO:0009774|GO:0009775 biological_process owl:Class
GO:0034905 biolink:NamedThing 5-chloro-4-hydroxy-2-oxopentanate aldolase activity Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde. got7fsn_ti UM-BBD_reactionID:r1437|EC:4.1.3.- molecular_function owl:Class
GO:0048058 biolink:NamedThing compound eye corneal lens development The process whose specific outcome is the progression of the corneal lens in the compound eye over time, from its formation to the mature structure. The corneal lens is a chitinous extracellular secretion of the four underlying cone cells and the pigment cells. got7fsn_ti biological_process owl:Class
GO:1900081 biolink:NamedThing regulation of arginine catabolic process Any process that modulates the frequency, rate or extent of arginine catabolic process. got7fsn_ti regulation of arginine breakdown|regulation of arginine degradation|regulation of arginine catabolism pr 2012-02-01T04:04:39Z biological_process owl:Class
GO:0033241 biolink:NamedThing regulation of cellular amine catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. got7fsn_ti regulation of amine catabolism|regulation of amine breakdown|regulation of amine degradation biological_process owl:Class
GO:0047131 biolink:NamedThing saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = L-glutamate + allysine + H(+) + NADH. got7fsn_ti dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, glutamate-forming)|aminoadipic semialdehyde synthase activity|6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)|N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming)|saccharopin dehydrogenase activity|NAD+ oxidoreductase (L-2-aminoadipic-delta-semialdehyde and glutamate forming) MetaCyc:1.5.1.9-RXN|EC:1.5.1.9|Reactome:R-HSA-70940|KEGG_REACTION:R02313|RHEA:24520 molecular_function owl:Class
GO:0019774 biolink:NamedThing proteasome core complex, beta-subunit complex The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus. got7fsn_ti cellular_component owl:Class
GO:0060880 biolink:NamedThing cell morphogenesis involved in semicircular canal fusion The change in form (cell shape and size) that occurs when a semicircular canal epithelial cell acquires the structural features that allow it to contribute to the process of semicircular canal fusion. got7fsn_ti dph 2009-08-13T10:13:25Z biological_process owl:Class
GO:0031356 biolink:NamedThing intrinsic component of chloroplast inner membrane The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to chloroplast inner membrane cellular_component owl:Class
GO:0038038 biolink:NamedThing G protein-coupled receptor homodimeric complex A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor. got7fsn_ti GPCR homodimer|G-protein coupled receptor homodimeric complex|G-protein coupled receptor homodimer bf 2011-11-02T04:43:53Z cellular_component owl:Class
GO:0050788 biolink:NamedThing sequestering of mercury The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system. got7fsn_ti sequestration of mercuric ion (Hg2+)|mercury (Hg) ion sequestering|mercury (Hg2+) ion storage|sequestering of mercuric ion (Hg2+)|retention of mercury (Hg2+) ion|mercuric ion (Hg2+) sequestering|mercuric ion (Hg2+) sequestration|sequestration of mercury (Hg) ion|storage of mercury (Hg2+) ion|mercury (Hg2+) ion retention|sequestering of mercury (Hg) ion|mercury (Hg) ion sequestration biological_process owl:Class
GO:0051238 biolink:NamedThing sequestering of metal ion The process of binding or confining metal ions such that they are separated from other components of a biological system. got7fsn_ti metal ion storage|retention of metal ion|metal ion retention|metal ion sequestration|storage of metal ion|sequestration of metal ion|metal ion sequestering biological_process owl:Class
GO:0098670 biolink:NamedThing entry receptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that mediates/triggers viral entry by endocytosis/pinocytosis or by inducing fusion/penetration. got7fsn_ti viral attachment to host entry receptor dos 2017-01-16T13:18:27Z VZ:3942 biological_process owl:Class
GO:0046813 biolink:NamedThing receptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface. got7fsn_ti virion attachment, binding of host cell surface receptor biological_process owl:Class
GO:0050817 biolink:NamedThing coagulation The process in which a fluid solution, or part of it, changes into a solid or semisolid mass. got7fsn_ti clotting biological_process owl:Class
GO:0102653 biolink:NamedThing gibberellin A51,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A51 + 2-oxoglutarate + O2 <=> H+ + gibberellin A51-catabolite + succinate + carbon dioxide + H2O. got7fsn_ti MetaCyc:RXN-172 molecular_function owl:Class
GO:0021544 biolink:NamedThing subpallium development The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon. got7fsn_ti biological_process owl:Class
GO:0035485 biolink:NamedThing adenine/guanine mispair binding Binding to a double-stranded DNA region containing an A/G mispair. got7fsn_ti G/A mispair binding|A/G mispair binding|guanine-adenine mispair binding bf 2010-04-23T10:55:43Z molecular_function owl:Class
GO:0102077 biolink:NamedThing oleamide hydrolase activity Catalysis of the reaction: oleamide + H2O <=> oleate + ammonium. got7fsn_ti RHEA:26506|EC:3.5.1.99|MetaCyc:RXN-10756 molecular_function owl:Class
GO:0005780 biolink:NamedThing extrinsic component of intraperoxisomal membrane The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti intra-peroxisomal peripheral membrane|extrinsic to intraperoxisomal membrane cellular_component owl:Class
GO:0047583 biolink:NamedThing 4-methyloxaloacetate esterase activity Catalysis of the reaction: 4-methoxy-2,4-dioxobutanoate + H(2)O = H(+) + methanol + oxaloacetate. got7fsn_ti oxaloacetate-4-methyl-ester oxaloacetohydrolase activity RHEA:10564|MetaCyc:4-METHYLOXALOACETATE-ESTERASE-RXN|KEGG_REACTION:R01144|EC:3.1.1.44 molecular_function owl:Class
GO:0003845 biolink:NamedThing 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+). got7fsn_ti corticosteroid 11-reductase|11beta-hydroxysteroid dehydrogenase|11beta-hydroxy steroid dehydrogenase|corticosteroid 11beta-dehydrogenase|beta-hydroxysteroid dehydrogenase https://github.com/geneontology/go-ontology/issues/21915 MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN|Reactome:R-HSA-194023|Wikipedia:11beta-hydroxysteroid_dehydrogenase molecular_function owl:Class
GO:0047351 biolink:NamedThing guanosine-triphosphate guanylyltransferase activity Catalysis of the reaction: 2 GTP = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate + H(+). got7fsn_ti GTP:GTP guanylyltransferase activity EC:2.7.7.45|MetaCyc:2.7.7.45-RXN|RHEA:18153|KEGG_REACTION:R00012 molecular_function owl:Class
GO:0061112 biolink:NamedThing negative regulation of bud outgrowth involved in lung branching Any process that decreases the rate, frequency, or extent of bud outgrowth involved in lung branching. got7fsn_ti dph 2010-05-05T11:20:42Z biological_process owl:Class
GO:0061048 biolink:NamedThing negative regulation of branching involved in lung morphogenesis Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. got7fsn_ti dph 2010-02-25T10:51:31Z biological_process owl:Class
GO:0007272 biolink:NamedThing ensheathment of neurons The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment. got7fsn_ti ionic insulation of neurons by glial cells biological_process owl:Class
GO:0021711 biolink:NamedThing cerebellar unipolar brush cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0060780 biolink:NamedThing intercalary leaflet morphogenesis The process in which the intercalary leaflet attains its shape. An intercalary leaflet is a leaflet that develops between primary leaflets. got7fsn_ti dph 2009-07-25T07:20:46Z biological_process owl:Class
GO:0043505 biolink:NamedThing CENP-A containing nucleosome A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3). got7fsn_ti centromeric nucleosome|centromere-specific nucleosome|CenH3 containing nucleosome|CNP-T-W-S-X complex|CENP-S-T-W-X|centromere specific nucleosome cellular_component owl:Class
GO:0000786 biolink:NamedThing nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. got7fsn_ti nuclear nucleosome|cytoplasmic nucleosome GO:0000787|GO:0000788|GO:0005718 Wikipedia:Nucleosome cellular_component owl:Class
GO:0034471 biolink:NamedThing ncRNA 5'-end processing Any process involved in forming the mature 5' end of a non-coding RNA molecule. got7fsn_ti ncRNA 5' end processing biological_process owl:Class
GO:0035752 biolink:NamedThing lysosomal lumen pH elevation Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. got7fsn_ti lysosome pH elevation bf 2011-03-23T10:24:24Z biological_process owl:Class
GO:0019429 biolink:NamedThing fluorene catabolic process The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents. got7fsn_ti fluorene degradation|fluorene metabolic process|fluorene breakdown|fluorene catabolism|fluorene metabolism GO:0018917 UM-BBD_pathwayID:flu|MetaCyc:FLUORENE-DEG-9-ONE-PWY biological_process owl:Class
GO:0031547 biolink:NamedThing brain-derived neurotrophic factor receptor signaling pathway The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands. got7fsn_ti BDNF signalling pathway|BDNF receptor signaling pathway|brain-derived neurotrophic factor receptor signalling pathway biological_process owl:Class
GO:0008531 biolink:NamedThing riboflavin kinase activity Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+). got7fsn_ti FK|flavokinase activity|riboflavin kinase (phosphorylating)|ATP:riboflavin 5'-phosphotransferase activity|riboflavine kinase activity KEGG_REACTION:R00549|RHEA:14357|EC:2.7.1.26|MetaCyc:RIBOFLAVINKIN-RXN|Reactome:R-HSA-196964 molecular_function owl:Class
GO:0042259 biolink:NamedThing peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12. got7fsn_ti peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine|peptidyl-L-beta-methylthioasparagine formation from peptidyl-asparagine|peptidyl-L-beta-methylthioasparagine anabolism from peptidyl-asparagine RESID:AA0320 biological_process owl:Class
GO:0030592 biolink:NamedThing DNA ADP-ribosylation The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16614 biological_process owl:Class
GO:0002699 biolink:NamedThing positive regulation of immune effector process Any process that activates or increases the frequency, rate, or extent of an immune effector process. got7fsn_ti activation of immune effector process|upregulation of immune effector process|up-regulation of immune effector process|stimulation of immune effector process|up regulation of immune effector process biological_process owl:Class
GO:0048363 biolink:NamedThing mucilage pectin metabolic process The chemical reactions and pathways involving the pectin component of mucilage. got7fsn_ti mucilage pectin metabolism biological_process owl:Class
GO:0045488 biolink:NamedThing pectin metabolic process The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge. got7fsn_ti pectin metabolism biological_process owl:Class
GO:0052630 biolink:NamedThing UDP-N-acetylgalactosamine diphosphorylase activity Catalysis of the reaction: UTP + N-acetyl-alpha-D-galactosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-galactosamine. got7fsn_ti N-acetylgalactosamine 1-phosphate uridylyltransferase|uridine diphosphoacetylgalactosamine phosphorylase activity|uridine diphosphoacetylgalactosamine pyrophosphorylase activity|UDP-GalNAc pyrophosphorylase activity|UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase activity|uridine diphosphate-N-acetylgalactosamine pyrophosphorylase activity|UDP-acetylgalactosamine pyrophosphorylase activity|UTP:2-acetamido-2-deoxy-alpha-D-galactose-1-phosphate uridylyltransferase activity|UDP-N-acetylgalactosamine pyrophosphorylase activity|N-acetylgalactosamine-1-phosphate uridyltransferase activity RHEA:34363|EC:2.7.7.83 molecular_function owl:Class
GO:0043591 biolink:NamedThing endospore external encapsulating structure The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer. got7fsn_ti peptidoglycan-based spore wall|spore wall|endospore wall GO:0055030 cellular_component owl:Class
GO:0005782 biolink:NamedThing peroxisomal matrix The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase. got7fsn_ti peroxisomal lumen GO:0031909 cellular_component owl:Class
GO:0031907 biolink:NamedThing microbody lumen The volume enclosed by the membranes of a microbody. got7fsn_ti cellular_component owl:Class
GO:0044588 biolink:NamedThing laminaribiose binding Binding to laminaribiose, a disaccharide. got7fsn_ti jl 2012-04-26T01:19:40Z molecular_function owl:Class
GO:0070492 biolink:NamedThing oligosaccharide binding Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. got7fsn_ti molecular_function owl:Class
GO:0106254 biolink:NamedThing lipid sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of a lipid. got7fsn_ti hjd 2020-03-09T17:36:09Z molecular_function owl:Class
GO:0140299 biolink:NamedThing small molecule sensor activity Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule. got7fsn_ti small molecular sensor activity pg 2018-12-10T14:30:28Z molecular_function owl:Class
GO:0005967 biolink:NamedThing mitochondrial pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase. got7fsn_ti pyruvate dehydrogenase complex (lipoamide) Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. cellular_component owl:Class
GO:0009701 biolink:NamedThing isoflavonoid phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. got7fsn_ti isoflavonoid phytoalexin synthesis|isoflavonoid phytoalexin biosynthesis|isoflavonoid phytoalexin anabolism|isoflavonoid phytoalexin formation biological_process owl:Class
GO:0009717 biolink:NamedThing isoflavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids. got7fsn_ti isoflavonoid biosynthesis|isoflavonoid anabolism|isoflavonoid formation|isoflavonoid synthesis biological_process owl:Class
GO:0000092 biolink:NamedThing mitotic anaphase B The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0000090 biolink:NamedThing mitotic anaphase The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0050293 biolink:NamedThing steroid-lactonase activity Catalysis of the reaction: H(2)O + testololactone = H(+) + testolate. got7fsn_ti testololactone lactonohydrolase activity KEGG_REACTION:R03641|RHEA:13721|EC:3.1.1.37|MetaCyc:STEROID-LACTONASE-RXN molecular_function owl:Class
GO:0000301 biolink:NamedThing retrograde transport, vesicle recycling within Golgi The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi. got7fsn_ti retrograde (vesicle recycling within Golgi) transport biological_process owl:Class
GO:0006891 biolink:NamedThing intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). got7fsn_ti intra-Golgi transport biological_process owl:Class
GO:0018609 biolink:NamedThing chlorobenzene dioxygenase activity Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene). got7fsn_ti UM-BBD_enzymeID:e0062|EC:1.14.12.- molecular_function owl:Class
GO:0033486 biolink:NamedThing delphinidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of delphinidin 3-O-glucoside, a basic, water-soluble anthocyanin responsible for blue coloration of flowers and fruits. got7fsn_ti delphinidin 3-O-glucoside formation|delphinidin 3-O-glucoside synthesis|delphinidin 3-O-glucoside anabolism|delphinidin 3-O-glucoside biosynthesis MetaCyc:PWY-5153 biological_process owl:Class
GO:0043583 biolink:NamedThing ear development The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. got7fsn_ti hearing organ development biological_process owl:Class
GO:0050201 biolink:NamedThing fucokinase activity Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+). got7fsn_ti fucokinase (phosphorylating) activity|L-fucose kinase activity|ATP:6-deoxy-L-galactose 1-phosphotransferase activity|ATP:beta-L-fucose 1-phosphotransferase activity|fucose kinase activity|L-fucokinase activity Reactome:R-HSA-6787540|MetaCyc:FUCOKINASE-RXN|EC:2.7.1.52|RHEA:13241|KEGG_REACTION:R03161 molecular_function owl:Class
GO:0060586 biolink:NamedThing multicellular organismal iron ion homeostasis Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism. got7fsn_ti dph 2009-05-08T02:18:21Z biological_process owl:Class
GO:0055072 biolink:NamedThing iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell. got7fsn_ti iron homeostasis biological_process owl:Class
GO:1990929 biolink:NamedThing sulfoquinovosidase activity Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose. got7fsn_ti tb 2016-02-19T01:18:37Z molecular_function owl:Class
GO:0033011 biolink:NamedThing perinuclear theca A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins. got7fsn_ti cellular_component owl:Class
GO:0044836 biolink:NamedThing D-xylose fermentation The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP. got7fsn_ti jl 2014-02-19T16:14:57Z biological_process owl:Class
GO:0033766 biolink:NamedThing 2-hydroxyquinoline 8-monooxygenase activity Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-2-ol = H(2)O + NAD(+) + quinoline-2,8-diol. got7fsn_ti 2-oxo-1,2-dihydroquinoline 8-monooxygenase activity|quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating) activity KEGG_REACTION:R05158|MetaCyc:1.14.13.61-RXN|EC:1.14.13.61|RHEA:22080 molecular_function owl:Class
GO:0061987 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter. got7fsn_ti dph 2018-02-15T17:48:00Z biological_process owl:Class
GO:0071447 biolink:NamedThing cellular response to hydroperoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH. got7fsn_ti mah 2009-12-16T04:16:42Z biological_process owl:Class
GO:0002510 biolink:NamedThing central B cell tolerance induction Tolerance induction of B cells in the bone marrow. got7fsn_ti central B-cell tolerance induction|central B-lymphocyte tolerance induction|central B lymphocyte tolerance induction biological_process owl:Class
GO:0002514 biolink:NamedThing B cell tolerance induction A process involving any mechanism for tolerance induction in B cells. got7fsn_ti B-cell tolerance induction|B lymphocyte tolerance induction|B-lymphocyte tolerance induction biological_process owl:Class
GO:0031646 biolink:NamedThing positive regulation of nervous system process Any process that activates or increases the frequency, rate or extent of a neurophysiological process. got7fsn_ti activation of neurological process|up regulation of neurological process|positive regulation of neurological process|stimulation of neurological process|up-regulation of neurological process|upregulation of neurological process|positive regulation of neurophysiological process|positive regulation of neurological system process biological_process owl:Class
GO:0005893 biolink:NamedThing interleukin-2 receptor complex A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits. got7fsn_ti IL-2 receptor complex cellular_component owl:Class
GO:0071477 biolink:NamedThing cellular hypotonic salinity response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. got7fsn_ti cellular response to hypotonic salt stress mah 2009-12-18T11:53:20Z biological_process owl:Class
GO:0004662 biolink:NamedThing CAAX-protein geranylgeranyltransferase activity Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. got7fsn_ti GGTase-I activity|type I protein geranyl-geranyltransferase activity|GGTaseI activity|protein geranylgeranyltransferase type I|geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity|geranylgeranyltransferase type I activity MetaCyc:2.5.1.60-RXN|EC:2.5.1.59|MetaCyc:RXN-3701 molecular_function owl:Class
GO:0032458 biolink:NamedThing slow endocytic recycling The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport. got7fsn_ti biological_process owl:Class
GO:1900619 biolink:NamedThing acetate ester metabolic process The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. got7fsn_ti acetyl ester metabolism|acetate ester metabolism|acetyl ester metabolic process bf 2012-05-16T12:29:51Z biological_process owl:Class
GO:1990521 biolink:NamedThing m7G(5')pppN diphosphatase activator activity Binds to and increases the activity of m7G(5')pppN diphosphatase. got7fsn_ti vw 2014-10-23T11:20:56Z molecular_function owl:Class
GO:0008068 biolink:NamedThing extracellularly glutamate-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. got7fsn_ti extracellular-glutamate-gated chloride channel activity Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. molecular_function owl:Class
GO:0005234 biolink:NamedThing extracellularly glutamate-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. got7fsn_ti extracellular-glutamate-gated ion channel activity Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. molecular_function owl:Class
GO:0002315 biolink:NamedThing marginal zone B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). got7fsn_ti marginal zone B cell development|marginal zone B-lymphocyte differentiation|marginal zone B lymphocyte differentiation|marginal zone B-cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:1990098 biolink:NamedThing core primosome complex A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication. got7fsn_ti core primosome The core primosome refers to a helicase-primase complex, and should not be confused with the more general GO term 'primosome complex ; GO:1990077'. bhm 2013-05-14T10:30:02Z cellular_component owl:Class
GO:0090704 biolink:NamedThing nicotinate-O-glucosyltransferase activity Catalysis of the reaction: nicotinate + UDP-D-glucose = O-D-glucosylnicotinate + UDP. got7fsn_ti tb 2016-09-21T12:46:21Z molecular_function owl:Class
GO:0140656 biolink:NamedThing endodeoxyribonuclease activator activity Binds to and increases the activity of an endodeoxyribonuclease. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21574 pg 2021-06-10T13:31:54Z molecular_function owl:Class
GO:0000727 biolink:NamedThing double-strand break repair via break-induced replication The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome. got7fsn_ti biological_process owl:Class
GO:0102433 biolink:NamedThing phenylalanine 4-hydroxylase (N10-formyl-tetrahydrofolate dependent) activity Catalysis of the reaction: L-phenylalanine + O2 + an N10-formyl-tetrahydrofolate <=> L-tyrosine + a 10-formyltetrahydrofolate-4a-carbinolamine. got7fsn_ti MetaCyc:RXN-13907 molecular_function owl:Class
GO:0044390 biolink:NamedThing ubiquitin-like protein conjugating enzyme binding Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. got7fsn_ti E2 protein ligase binding|small protein conjugating enzyme binding jl 2011-12-15T04:38:44Z molecular_function owl:Class
GO:0050477 biolink:NamedThing acyl-lysine deacylase activity Catalysis of the reaction: H2O + N6-acyl-L-lysine = L-lysine + a carboxylate. got7fsn_ti N6-acyl-L-lysine amidohydrolase activity|6-N-acyl-L-lysine amidohydrolase activity|epsilon-lysine acylase activity MetaCyc:ACYL-LYSINE-DEACYLASE-RXN|EC:3.5.1.17|RHEA:24548 molecular_function owl:Class
GO:0019075 biolink:NamedThing virus maturation The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release. got7fsn_ti viral maturation|bacteriophage maturation biological_process owl:Class
GO:0019168 biolink:NamedThing 2-octaprenylphenol hydroxylase activity Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O. got7fsn_ti RHEA:27790|MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN molecular_function owl:Class
GO:0032011 biolink:NamedThing ARF protein signal transduction A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state. got7fsn_ti biological_process owl:Class
GO:0034855 biolink:NamedThing 4-AD 9alpha-hydroxylase activity Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O. got7fsn_ti UM-BBD_reactionID:r1153|EC:1.14.15.- molecular_function owl:Class
GO:0047642 biolink:NamedThing aldose beta-D-fructosyltransferase activity Catalysis of the reaction: alpha-D-aldosyl1 beta-D-fructoside + D-aldose2 = D-aldose1 + alpha-D-aldosyl2 beta-D-fructoside. got7fsn_ti alpha-D-aldosyl-beta-D-fructoside:aldose 1-beta-D-fructosyltransferase activity|aldose b-D-fructosyltransferase activity MetaCyc:ALDOSE-BETA-FRUCTOSYLTRANSFERASE-RXN|EC:2.4.1.162 molecular_function owl:Class
GO:0050738 biolink:NamedThing fructosyltransferase activity Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid. got7fsn_ti molecular_function owl:Class
GO:0016621 biolink:NamedThing cinnamoyl-CoA reductase activity Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+. got7fsn_ti ferulyl-CoA reductase activity|cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)|p-hydroxycinnamoyl coenzyme A reductase activity|cinnamoyl CoA reductase activity|cinnamoyl-CoA:NADPH reductase activity|feruloyl-CoA reductase activity|cinnamoyl-coenzyme A reductase activity|feruloyl coenzyme A reductase activity RHEA:10620|EC:1.2.1.44|MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN molecular_function owl:Class
GO:0019690 biolink:NamedThing pyrimidine deoxyribonucleoside interconversion The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside. got7fsn_ti biological_process owl:Class
GO:0019689 biolink:NamedThing pyrimidine nucleoside interconversion The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside. got7fsn_ti biological_process owl:Class
GO:0030043 biolink:NamedThing actin filament fragmentation The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins. got7fsn_ti biological_process owl:Class
GO:0030042 biolink:NamedThing actin filament depolymerization Disassembly of actin filaments by the removal of actin monomers from a filament. got7fsn_ti actin depolymerizing activity|actin depolymerization biological_process owl:Class
GO:0047785 biolink:NamedThing cortisol sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H(+). got7fsn_ti glucocorticosteroid sulfotransferase activity|glucocorticoid sulfotransferase activity|3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity|cortisol sulphotransferase activity KEGG_REACTION:R02839|MetaCyc:CORTISOL-SULFOTRANSFERASE-RXN|EC:2.8.2.18|RHEA:11884 molecular_function owl:Class
GO:0050256 biolink:NamedThing ribitol-5-phosphate 2-dehydrogenase activity Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+. got7fsn_ti dehydrogenase, ribitol 5-phosphate|D-ribitol-5-phosphate:NAD(P)+ 2-oxidoreductase activity MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN|EC:1.1.1.137 molecular_function owl:Class
GO:0033240 biolink:NamedThing positive regulation of cellular amine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines. got7fsn_ti positive regulation of amine metabolism biological_process owl:Class
GO:0043049 biolink:NamedThing otic placode formation The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain. got7fsn_ti biological_process owl:Class
GO:0060032 biolink:NamedThing notochord regression The developmental process in which the stucture of the notochord is destroyed in an embryo. got7fsn_ti biological_process owl:Class
GO:0018556 biolink:NamedThing 2,2',3-trihydroxybiphenyl dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate). got7fsn_ti UM-BBD_enzymeID:e0032|EC:1.13.11.- molecular_function owl:Class
GO:0070576 biolink:NamedThing vitamin D 24-hydroxylase activity Catalysis of the hydroxylation of C-24 of any form of vitamin D. got7fsn_ti ergocalciferol 24-hydroxylase activity|vitamin D3 24-hydroxylase activity|vitamin D2 24-hydroxylase activity|cholecalciferol 24-hydroxylase activity|calciferol 24-hydroxylase activity mah 2009-04-21T02:20:52Z molecular_function owl:Class
GO:0060985 biolink:NamedThing epicardium-derived cardiac vascular smooth muscle cell fate commitment The commitment of an epicardial cell to a cardiac vascular smooth muscle cell fate and its capacity to differentiate into a cardiac vascular smooth muscle cell. got7fsn_ti dph 2009-10-06T03:11:11Z biological_process owl:Class
GO:0097129 biolink:NamedThing cyclin D2-CDK4 complex A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:53:15Z cellular_component owl:Class
GO:0031130 biolink:NamedThing creation of an inductive signal The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter. got7fsn_ti biological_process owl:Class
GO:0010731 biolink:NamedThing protein glutathionylation The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage. got7fsn_ti protein amino acid glutathionylation biological_process owl:Class
GO:0030060 biolink:NamedThing L-malate dehydrogenase activity Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. got7fsn_ti NAD-dependent malic dehydrogenase activity|NAD-dependent malate dehydrogenase activity|MDH|malic dehydrogenase activity|NAD-malic dehydrogenase activity|NAD-malate dehydrogenase activity|L-malate-NAD+ oxidoreductase activity|malic acid dehydrogenase activity|(S)-malate:NAD+ oxidoreductase activity|NAD-linked malate dehydrogenase activity|NAD-L-malate dehydrogenase activity|NAD-specific malate dehydrogenase activity|malate (NAD) dehydrogenase activity MetaCyc:MALATE-DEH-RXN|RHEA:21432|EC:1.1.1.37|Reactome:R-HSA-70979|Reactome:R-HSA-71783|Reactome:R-HSA-198508 molecular_function owl:Class
GO:0140573 biolink:NamedThing histone H3-containing nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins containing the histone H3, which forms the primary packing unit of DNA into higher order structures. got7fsn_ti histone H3 containing nucleosome https://github.com/geneontology/go-ontology/issues/20585 pg 2021-01-04T16:22:43Z cellular_component owl:Class
GO:0046214 biolink:NamedThing enterobactin catabolic process The chemical reactions and pathways resulting in the breakdown of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. got7fsn_ti enterobactin degradation|enterobactin catabolism|enterobactin breakdown biological_process owl:Class
GO:0019614 biolink:NamedThing catechol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. got7fsn_ti catechol breakdown|catechol catabolic process|catechol degradation|catechol catabolism biological_process owl:Class
GO:0047692 biolink:NamedThing ATP deaminase activity Catalysis of the reaction: ATP + H2O = ITP + NH3. got7fsn_ti adenosine triphosphate deaminase activity|ATP aminohydrolase activity EC:3.5.4.18|RHEA:13037|MetaCyc:ATP-DEAMINASE-RXN molecular_function owl:Class
GO:0033278 biolink:NamedThing cell proliferation in midbrain The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain. got7fsn_ti cell proliferation in mesencephalon|mesencepahalic cell proliferation biological_process owl:Class
GO:0061383 biolink:NamedThing trabecula morphogenesis The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. got7fsn_ti dph 2010-12-02T08:51:45Z biological_process owl:Class
GO:0072312 biolink:NamedThing metanephric glomerular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular epithelial cell. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. got7fsn_ti mah 2010-04-09T06:54:15Z biological_process owl:Class
GO:1990265 biolink:NamedThing platelet-derived growth factor complex A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). got7fsn_ti PDGF complex|PDGF-AA dimer|PDGF-AB dimer|PDGF-BB dimer|PDGF-DD dimer|PDGF-CC dimer An example of this is PDGFA in human (P04085) in PMID:20534510 (inferred from direct assay). bhm 2014-01-09T16:09:11Z cellular_component owl:Class
GO:0050597 biolink:NamedThing taxane 10-beta-hydroxylase activity Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+). got7fsn_ti 5-alpha-taxadienol-10-beta-hydroxylase activity|taxane 10b-hydroxylase activity|taxane 10beta-hydroxylase activity|taxa-4(20),11-dien-5alpha-yl acetate,NADPH:oxygen oxidoreductase (10beta-hydroxylating) KEGG_REACTION:R06309|EC:1.14.14.105|MetaCyc:1.14.13.76-RXN|RHEA:15241 molecular_function owl:Class
GO:0000718 biolink:NamedThing nucleotide-excision repair, DNA damage removal The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage. got7fsn_ti biological_process owl:Class
GO:0002361 biolink:NamedThing CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell. got7fsn_ti CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation|CD4-positive, CD25-positive, alpha-beta regulatory T cell development|CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation|CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0051089 biolink:NamedThing constitutive protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands. got7fsn_ti biological_process owl:Class
GO:0006509 biolink:NamedThing membrane protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). got7fsn_ti receptor shedding|membrane protein solubilization|ectoderm shedding|ectodomain cleavage biological_process owl:Class
GO:0050393 biolink:NamedThing vinylacetyl-CoA delta-isomerase activity Catalysis of the reaction: vinylacetyl-CoA = crotonoyl-CoA. got7fsn_ti vinylacetyl-CoA delta3-delta2-isomerase activity|vinylacetyl-CoA D-isomerase activity|delta3-cis-delta2-trans-enoyl-CoA isomerase|vinylacetyl coenzyme A isomerase activity|vinylacetyl coenzyme A delta-isomerase activity MetaCyc:VINYLACETYL-COA-DELTA-ISOMERASE-RXN|EC:5.3.3.3|KEGG_REACTION:R03031|RHEA:10572 molecular_function owl:Class
GO:0008736 biolink:NamedThing L-fucose isomerase activity Catalysis of the reaction: L-fucose = L-fuculose. got7fsn_ti L-fucose ketol-isomerase activity|L-fucose aldose-ketose-isomerase activity MetaCyc:FUCISOM-RXN|RHEA:17233|EC:5.3.1.25 molecular_function owl:Class
GO:0006972 biolink:NamedThing hyperosmotic response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell. got7fsn_ti HOG response|response to hypertonicity|hypertonic response biological_process owl:Class
GO:0097085 biolink:NamedThing interferon regulatory factor 3-interferon regulatory factor 5 complex An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5. got7fsn_ti IRF3:IRF5 complex pr 2011-06-21T06:30:30Z cellular_component owl:Class
GO:0051368 biolink:NamedThing peptidyl-threonine octanoylation The octanoylation of peptidyl-threonine to form peptidyl-O3-octanoyl-L-threonine, typical of the protein ghrelin. got7fsn_ti RESID:AA0386 biological_process owl:Class
GO:0008331 biolink:NamedThing high voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. got7fsn_ti high voltage gated calcium channel activity|Q-type calcium channel|P-type calcium channel|high voltage-dependent calcium channel activity|N-type calcium channel|L-type calcium channel molecular_function owl:Class
GO:0022002 biolink:NamedThing negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell. got7fsn_ti Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate|Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate|Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate|Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate|Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate|Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway biological_process owl:Class
GO:0022001 biolink:NamedThing negative regulation of anterior neural cell fate commitment of the neural plate Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate. got7fsn_ti down-regulation of anterior neural cell fate of the neural plate|negative regulation of anterior neural cell fate of the neural plate|inhibition of anterior neural cell fate of the neural plate|posteriorization|caudalization of neural plate|downregulation of anterior neural cell fate of the neural plate|down regulation of anterior neural cell fate of the neural plate biological_process owl:Class
GO:0043857 biolink:NamedThing N-acetylornithine carbamoyltransferase activity Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H(+) + phosphate. got7fsn_ti carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase activity|N-acetylornithine transcarbamylase activity|AOTC|carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase activity|acetylornithine transcarbamylase activity KEGG_REACTION:R07245|RHEA:18609|EC:2.1.3.9|MetaCyc:2.1.3.9-RXN molecular_function owl:Class
GO:0009733 biolink:NamedThing response to auxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. got7fsn_ti response to auxin stimulus biological_process owl:Class
GO:0006385 biolink:NamedThing transcription elongation from RNA polymerase III promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III. got7fsn_ti RNA elongation from Pol III promoter|RNA polymerase III transcription elongation factor activity biological_process owl:Class
GO:0006354 biolink:NamedThing DNA-templated transcription, elongation The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. got7fsn_ti RNA elongation|transcription elongation, DNA-dependent|DNA-dependent transcription, elongation|transcriptional elongation, DNA-dependent biological_process owl:Class
GO:0140253 biolink:NamedThing cell-cell fusion A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium. got7fsn_ti cell fusion|cell cell fusion https://github.com/geneontology/go-ontology/issues/15939 pg 2018-08-13T18:38:18Z biological_process owl:Class
GO:0001996 biolink:NamedThing positive regulation of heart rate by epinephrine-norepinephrine The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction. got7fsn_ti increased chronotropy by epinephrine-norepinephrine|upregulation of heart contraction rate by epinephrine-norepinephrine|positive regulation of heart contraction rate by adrenaline-noradrenaline|positive regulation of cardiac contraction rate by epinephrine-norepinephrine|stimulation of heart contraction rate by epinephrine-norepinephrine|up regulation of heart contraction rate by epinephrine-norepinephrine|up-regulation of heart contraction rate by epinephrine-norepinephrine|activation of heart contraction rate by epinephrine-norepinephrine|positive regulation of heart contraction rate by epinephrine-norepinephrine|positive control of heart contraction rate by epinephrine-norepinephrine biological_process owl:Class
GO:0061418 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to hypoxia Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. got7fsn_ti dph 2012-01-23T01:05:59Z biological_process owl:Class
GO:0008810 biolink:NamedThing cellulase activity Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. got7fsn_ti beta-1,4-glucanase activity|1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity|avicelase activity|endo-1,4-beta-glucanase activity|endoglucanase activity|beta-1,4-endoglucan hydrolase activity|celludextrinase activity|9.5 cellulase activity|cellulase A 3|endoglucanase D|cellulosin AP|pancellase SS|carboxymethyl cellulase activity|endo-1,4-beta-D-glucanase activity|endo-1,4-beta-D-glucanohydrolase activity|alkali cellulase activity|celluase A MetaCyc:RXN-2043|EC:3.2.1.4 molecular_function owl:Class
GO:0103059 biolink:NamedThing UDP-L-rhamnose:kaempferol 3-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol oxoanion + UDP-L-rhamnose <=> H+ + kaempferol-3-rhamnoside + UDP(3-). got7fsn_ti MetaCyc:RXN1F-474|RHEA:61164 molecular_function owl:Class
GO:0071105 biolink:NamedThing response to interleukin-11 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus. got7fsn_ti response to IL-11 mah 2009-11-09T12:52:51Z biological_process owl:Class
GO:0046681 biolink:NamedThing response to carbamate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase. got7fsn_ti carbamate resistance|carbamate susceptibility/resistance biological_process owl:Class
GO:0009103 biolink:NamedThing lipopolysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. got7fsn_ti lipopolysaccharide anabolism|lipopolysaccharide biosynthesis|lipopolysaccharide synthesis|LPS biosynthetic process|lipopolysaccharide formation KEGG_PATHWAY:map00540 biological_process owl:Class
GO:0060745 biolink:NamedThing mammary gland branching involved in pregnancy The process in which the branching structure of the mammary gland duct is generated and organized as a part of pregnancy. got7fsn_ti dph 2009-06-22T08:25:19Z biological_process owl:Class
GO:0006180 biolink:NamedThing deoxyguanosine salvage Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0036154 biolink:NamedThing diacylglycerol acyl-chain remodeling Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains. got7fsn_ti diglyceride acyl-chain remodeling bf 2012-03-14T02:53:14Z biological_process owl:Class
GO:0046339 biolink:NamedThing diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group. got7fsn_ti diacylglycerol metabolism|diglyceride metabolism biological_process owl:Class
GO:0005838 biolink:NamedThing proteasome regulatory particle A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. got7fsn_ti PA700-dependent proteasome activator|modulator complex|19S regulatory particle|PA700 proteasome activator cellular_component owl:Class
GO:0055046 biolink:NamedThing microgametogenesis The process whose specific outcome is the progression of the pollen grain over time, from its formation as the microspore to the mature structure. got7fsn_ti pollen development from the microspore Wikipedia:Microgametogenesis biological_process owl:Class
GO:0150007 biolink:NamedThing clathrin-dependent synaptic vesicle endocytosis Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds. got7fsn_ti bc 2017-12-01T10:11:35Z biological_process owl:Class
GO:0101002 biolink:NamedThing ficolin-1-rich granule Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry. got7fsn_ti ficolin granule|ficolin-1 rich granule cellular_component owl:Class
GO:0099542 biolink:NamedThing trans-synaptic signaling by endocannabinoid Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand. got7fsn_ti biological_process owl:Class
GO:0099541 biolink:NamedThing trans-synaptic signaling by lipid Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. got7fsn_ti biological_process owl:Class
GO:0035642 biolink:NamedThing histone methyltransferase activity (H3-R17 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3. got7fsn_ti histone methylase activity (H3-R17 specific)|histone-arginine N-methyltransferase activity (H3-R17 specific) bf 2011-01-19T10:41:43Z molecular_function owl:Class
GO:0071685 biolink:NamedThing NADH dehydrogenase complex (plastoquinone) An NADH dehydrogenase complex that catalyzes the transfer of electrons to plastoquinone. The complex is involved in the non-photochemical reduction of plastoquinones and the cyclic electron transport around photosystem I, and is found in plastid thylakoids. got7fsn_ti mah 2010-02-19T05:20:45Z cellular_component owl:Class
GO:0030964 biolink:NamedThing NADH dehydrogenase complex An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. got7fsn_ti NADH dehydrogenase complex (ubiquinone)|NADH dehydrogenase complex (plastoquinone)|NADH:plastoquinone reductase complex|Complex I|plastid NADH dehydrogenase complex (plastoquinone)|NADH dehydrogenase complex (quinone) Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'. GO:0031677|GO:0030025|GO:0045280|GO:0031678|GO:0031675|GO:0030966 Wikipedia:NADH_dehydrogenase cellular_component owl:Class
GO:0140093 biolink:NamedThing esBAF complex An embryonic stem cell-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or an ortholog thereof. Compared to many other BAF complexes never contains ACTL6B/BAF53B, ARID1B/BAF250B, SMARCA2/BRM, SMARCC2/BAF170 or SMARCD3/BAF60C but contains PHF10/BAF45A, DPF2/BAF45D and possibly one of BCL7A/B/C. got7fsn_ti embryonic stem cell-specific BAF complex|embryonic stem cell-specific SWI/SNF complex pg 2017-09-05T09:23:51Z cellular_component owl:Class
GO:0061121 biolink:NamedThing regulation of positive chemotaxis to cAMP by DIF-2 Any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. got7fsn_ti dph 2010-05-17T08:16:21Z biological_process owl:Class
GO:0021504 biolink:NamedThing neural fold hinge point formation The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube. got7fsn_ti neural fold furrowing biological_process owl:Class
GO:0034716 biolink:NamedThing Gemin3-Gemin4-Gemin5 complex A protein complex that contains Gemin3 (DDX20), Gemin4, and Gemin5, and can bind to snRNAs; may be an intermediate in SMN complex assembly. got7fsn_ti cellular_component owl:Class
GO:0035238 biolink:NamedThing vitamin A biosynthetic process The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids. got7fsn_ti vitamin A anabolism|vitamin A biosynthesis|vitamin A formation|vitamin A synthesis biological_process owl:Class
GO:0018710 biolink:NamedThing acetone carboxylase activity Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate. got7fsn_ti acetone:carbon-dioxide ligase (AMP-forming) MetaCyc:6.4.1.6-RXN|KEGG_REACTION:R05735|EC:6.4.1.6|RHEA:18385 molecular_function owl:Class
GO:0016885 biolink:NamedThing ligase activity, forming carbon-carbon bonds Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti EC:6.4.-.- molecular_function owl:Class
GO:0010052 biolink:NamedThing guard cell differentiation The process in which a guard mother cell acquires the specialized features of a guard cell. got7fsn_ti stomatal cell differentiation biological_process owl:Class
GO:0034279 biolink:NamedThing syn-pimara-7,15-diene synthase activity Catalysis of the reaction: 9-alpha-copalyl diphosphate = 9-beta-pimara-7,15-diene + diphosphate. got7fsn_ti 9alpha-copalyl-diphosphate diphosphate-lyase (9beta-pimara-7,15-diene-forming) activity RHEA:25560|EC:4.2.3.35|MetaCyc:RXN-4883|KEGG_REACTION:R09117 molecular_function owl:Class
GO:0003988 biolink:NamedThing acetyl-CoA C-acyltransferase activity Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. got7fsn_ti beta-ketoadipyl-CoA thiolase activity|acyl-CoA:acetyl-CoA C-acyltransferase activity|pro-3-ketoacyl-CoA thiolase activity|3-ketoacyl CoA thiolase activity|acetoacetyl-CoA beta-ketothiolase activity|beta-ketoacyl-CoA thiolase activity|beta-ketoadipyl coenzyme A thiolase activity|3-oxoacyl-CoA thiolase activity|ketoacyl-coenzyme A thiolase activity|3-ketoacyl thiolase activity|2-keto-acyl thiolase activity|2-methylacetoacetyl-CoA thiolase|beta-ketothiolase activity|KAT|acetyl-CoA acyltransferase activity|ketoacyl-CoA acyltransferase activity|3-oxoacyl-coenzyme A thiolase activity|beta-ketoacyl coenzyme A thiolase activity|thiolase I|6-oxoacyl-CoA thiolase activity|3-ketoacyl-CoA thiolase activity|3-ketoacyl coenzyme A thiolase activity|long-chain 3-oxoacyl-CoA thiolase activity|oxoacyl-coenzyme A thiolase activity|3-ketothiolase activity Reactome:R-HSA-77271|MetaCyc:KETOACYLCOATHIOL-RXN|Reactome:R-HSA-77321|EC:2.3.1.16|Reactome:R-HSA-390250|Reactome:R-HSA-77329|RHEA:21564|UM-BBD_reactionID:r1051|Reactome:R-HSA-8874745|Reactome:R-HSA-77340|Reactome:R-HSA-77304|Reactome:R-HSA-77309 molecular_function owl:Class
GO:0072741 biolink:NamedThing protein localization to cell division site A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division. got7fsn_ti protein localisation to cell division site mah 2012-08-16T11:51:48Z biological_process owl:Class
GO:0000291 biolink:NamedThing nuclear-transcribed mRNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail. got7fsn_ti exonucleolytic degradation of mRNA|mRNA degradation, exonucleolytic|mRNA breakdown, exonucleolytic|nuclear mRNA catabolic process, exonucleolytic biological_process owl:Class
GO:0071607 biolink:NamedThing macrophage inflammatory protein-1 gamma production The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CCL9 production|chemokine (C-C motif) ligand 9 production|MIP-1g production mah 2010-02-05T04:19:52Z biological_process owl:Class
GO:0023051 biolink:NamedThing regulation of signaling Any process that modulates the frequency, rate or extent of a signaling process. got7fsn_ti regulation of signaling process|regulation of signalling process 2010-02-16T09:30:50Z biological_process owl:Class
GO:0062116 biolink:NamedThing phenyloplast A chloroplast-derived plastid in which the solid form of phenol is stored. got7fsn_ti dph 2019-03-15T11:57:05Z cellular_component owl:Class
GO:0010146 biolink:NamedThing fructan biosynthetic process The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues. got7fsn_ti fructan synthesis|fructan formation|fructan anabolism|levan biosynthetic process|levan biosynthesis|fructan biosynthesis MetaCyc:PWY-822 biological_process owl:Class
GO:0102083 biolink:NamedThing 7,8-dihydromonapterin aldolase activity Catalysis of the reaction: 7,8-dihydromonapterin <=> glycolaldehyde + 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-ol. got7fsn_ti MetaCyc:RXN-10857 molecular_function owl:Class
GO:0060604 biolink:NamedThing mammary gland duct cavitation Creation of the central hole of the mammary gland duct by the hollowing out of a solid rod. got7fsn_ti milk duct cavitation dph 2009-05-15T09:34:07Z biological_process owl:Class
GO:0050391 biolink:NamedThing valine dehydrogenase (NADP) activity Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH. got7fsn_ti valine dehydrogenase (NADP+) activity|L-valine:NADP+ oxidoreductase (deaminating)|valine dehydrogenase (nicotinanide adenine dinucleotide phosphate) RHEA:11156|MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN|EC:1.4.1.8 molecular_function owl:Class
GO:0042010 biolink:NamedThing interleukin-15 receptor activity Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-15R|IL-15 receptor activity molecular_function owl:Class
GO:0016691 biolink:NamedThing chloride peroxidase activity Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O. got7fsn_ti cofactor-free chloroperoxidase activity|vanadium chloroperoxidase activity|chloride:hydrogen-peroxide oxidoreductase|chloroperoxidase activity|flavin-heme chloroperoxidase activity|haem chloroperoxidase activity|flavin-haem chloroperoxidase activity|heme chloroperoxidase activity GO:0016957|GO:0016955|GO:0016958|GO:0016956 MetaCyc:CHLORIDE-PEROXIDASE-RXN|EC:1.11.1.10 molecular_function owl:Class
GO:0036068 biolink:NamedThing light-independent chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light. got7fsn_ti light-independent chlorophyll biosynthesis|light-independent chlorophyll synthesis|light independent chlorophyll biosynthetic process|light-independent chlorophyll anabolism|light-independent chlorophyll formation bf 2011-12-15T04:44:18Z biological_process owl:Class
GO:0015995 biolink:NamedThing chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. got7fsn_ti chlorophyll biosynthesis|chlorophyll formation|chlorophyll anabolism|chlorophyll synthesis MetaCyc:CHLOROPHYLL-SYN biological_process owl:Class
GO:0046574 biolink:NamedThing glycuronidase activity Catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid. got7fsn_ti glucuronyl hydrolase activity molecular_function owl:Class
GO:0034891 biolink:NamedThing endosulfan diol dehydrogenase activity Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1388 molecular_function owl:Class
GO:0046164 biolink:NamedThing alcohol catabolic process The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. got7fsn_ti alcohol degradation|alcohol breakdown|alcohol catabolism biological_process owl:Class
GO:0070772 biolink:NamedThing PAS complex A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p. got7fsn_ti autophagy-specific phosphatidylinositol 3-kinase complex mah 2009-06-30T11:13:32Z cellular_component owl:Class
GO:0021707 biolink:NamedThing cerebellar granule cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0009926 biolink:NamedThing auxin polar transport The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally. got7fsn_ti biological_process owl:Class
GO:0047472 biolink:NamedThing 3-carboxy-cis,cis-muconate cycloisomerase activity Catalysis of the reaction: 2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate = 3-carboxy-cis,cis-muconate + H(+). got7fsn_ti 3-carboxymuconolactone hydrolase activity|CMLE activity|3-carboxymuconate lactonizing enzyme activity|beta-carboxymuconate lactonizing enzyme activity|3-carboxymuconate cycloisomerase type II activity https://github.com/geneontology/go-ontology/issues/21794 GO:0018842 EC:5.5.1.2|MetaCyc:5.5.1.2-RXN|KEGG_REACTION:R03307|RHEA:23656|UM-BBD_reactionID:r0582 molecular_function owl:Class
GO:0071136 biolink:NamedThing alpha7-beta1 integrin-laminin alpha-2 complex A protein complex that consists of an alpha7-beta1 integrin complex bound to laminin alpha-2. got7fsn_ti ITGA7-ITGB1-LAMA2 complex mah 2009-11-13T02:29:42Z cellular_component owl:Class
GO:0102801 biolink:NamedThing anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity Catalysis of the reaction: 4'''-demalonylsalvianin + malonyl-CoA = salvianin + coenzyme A. got7fsn_ti EC:2.3.1.214|MetaCyc:RXN-8139|RHEA:35515 molecular_function owl:Class
GO:2000344 biolink:NamedThing positive regulation of acrosome reaction Any process that activates or increases the frequency, rate or extent of the acrosome reaction. got7fsn_ti yaf 2011-02-01T12:02:18Z biological_process owl:Class
GO:0036128 biolink:NamedThing CatSper complex A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits. got7fsn_ti CATSPER channel|CatSper channel complex bf 2012-03-02T10:26:48Z cellular_component owl:Class
GO:0005891 biolink:NamedThing voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. got7fsn_ti voltage-sensitive calcium channel complex|voltage-dependent calcium channel complex|voltage gated calcium channel complex cellular_component owl:Class
GO:0021863 biolink:NamedThing forebrain neuroblast differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti abventricular progenitor cell differentiation|intermediate progenitor cell differentiation|non-surface dividing progenitor cell differentiation biological_process owl:Class
GO:0014016 biolink:NamedThing neuroblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts. got7fsn_ti biological_process owl:Class
GO:1904057 biolink:NamedThing negative regulation of sensory perception of pain Any process that stops, prevents or reduces the frequency, rate or extent of sensory perception of pain. got7fsn_ti inhibition of nociception|inhibition of perception of physiological pain|down-regulation of perception of physiological pain|down-regulation of sensory perception of pain|down regulation of nociception|inhibition of sensory perception of pain|down regulation of sensory perception of pain|downregulation of perception of physiological pain|down regulation of perception of physiological pain|negative regulation of nociception|downregulation of nociception|downregulation of sensory perception of pain|down-regulation of nociception|negative regulation of perception of physiological pain sl 2015-03-18T20:33:57Z biological_process owl:Class
GO:0061527 biolink:NamedThing dopamine secretion, neurotransmission The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter. got7fsn_ti dph 2013-06-21T15:43:15Z biological_process owl:Class
GO:0033851 biolink:NamedThing lavandulyl diphosphate synthase activity Catalysis of the reaction: 2 dimethylallyl diphosphate = diphosphate + lavandulyl diphosphate. got7fsn_ti dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (lavandulyl-diphosphate-forming) activity|FDS-5 KEGG_REACTION:R08950|RHEA:21676|MetaCyc:2.5.1.69-RXN|EC:2.5.1.69 molecular_function owl:Class
GO:0019826 biolink:NamedThing oxygen sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). got7fsn_ti molecular_function owl:Class
GO:0016575 biolink:NamedThing histone deacetylation The modification of histones by removal of acetyl groups. got7fsn_ti biological_process owl:Class
GO:0002497 biolink:NamedThing proteasomal proteolysis associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation. got7fsn_ti biological_process owl:Class
GO:0002496 biolink:NamedThing proteolysis associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation. got7fsn_ti biological_process owl:Class
GO:0071749 biolink:NamedThing polymeric IgA immunoglobulin complex A protein complex composed of two, three, or four monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through disulfide binded monomers of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti polymeric IgA antibody|polymeric IgA1 antibody|pIgA1 antibody|pIgA antibody Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a polymeric forms. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0016442 biolink:NamedThing RISC complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. got7fsn_ti miRNP complex|micro-ribonucleoprotein complex|RNA-induced silencing complex GO:0035068 Wikipedia:RNA-induced_silencing_complex cellular_component owl:Class
GO:0031332 biolink:NamedThing RNAi effector complex Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins. got7fsn_ti cellular_component owl:Class
GO:0019649 biolink:NamedThing formaldehyde assimilation The pathways in which formaldehyde is processed and used as a carbon source for the cell. got7fsn_ti biological_process owl:Class
GO:0102581 biolink:NamedThing cyanidin 3-O-glucoside-p-coumaroyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 4-coumaryl-CoA + H+ <=> cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + coenzyme A. got7fsn_ti MetaCyc:RXN-15327 molecular_function owl:Class
GO:0005225 biolink:NamedThing volume-sensitive anion channel activity Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. got7fsn_ti volume-regulated channel Reactome:R-HSA-8941543 molecular_function owl:Class
GO:0005253 biolink:NamedThing anion channel activity Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient. got7fsn_ti non-selective anion channel activity Reactome:R-HSA-432036|Reactome:R-HSA-432034 molecular_function owl:Class
GO:0021513 biolink:NamedThing spinal cord dorsal/ventral patterning The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord. got7fsn_ti spinal cord dorsal-ventral patterning|spinal cord dorsoventral patterning biological_process owl:Class
GO:0046775 biolink:NamedThing suppression by virus of host cytokine production Any viral process that results in the inhibition of host cell cytokine production. got7fsn_ti negative regulation by virus of host cytokine production biological_process owl:Class
GO:0044831 biolink:NamedThing modulation by virus of host cytokine production Any process in which a virus modulates the frequency, rate or extent of cytokine production in its host organism. got7fsn_ti jl 2014-02-06T12:49:02Z biological_process owl:Class
GO:0019985 biolink:NamedThing translesion synthesis The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide. got7fsn_ti bypass DNA synthesis biological_process owl:Class
GO:1900047 biolink:NamedThing negative regulation of hemostasis Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis. got7fsn_ti down-regulation of hemostasis|downregulation of hemostasis|down regulation of hemostasis|inhibition of hemostasis jl 2012-01-19T03:23:42Z biological_process owl:Class
GO:0047724 biolink:NamedThing inosine nucleosidase activity Catalysis of the reaction: inosine + H2O = D-ribose + hypoxanthine. got7fsn_ti inosine ribohydrolase activity|inosine-guanosine nucleosidase activity|inosinase activity EC:3.2.2.2|MetaCyc:INOSINE-NUCLEOSIDASE-RXN|RHEA:16657 molecular_function owl:Class
GO:0031022 biolink:NamedThing nuclear migration along microfilament The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. got7fsn_ti nuclear migration, microfilament-mediated biological_process owl:Class
GO:0009011 biolink:NamedThing starch synthase activity Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). got7fsn_ti ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|ADP-glucose starch synthase activity|ADP-glucose--starch glucosyltransferase activity|ADPglucose-starch glucosyltransferase activity|ADPG-starch glucosyltransferase activity|ADP-glucose transglucosylase activity|starch synthetase activity|adenosine diphosphate glucose-starch glucosyltransferase activity|glycogen synthase activity|starch (bacterial glycogen) synthase activity|ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity|ADPG starch synthetase activity|adenosine diphosphoglucose-starch glucosyltransferase activity MetaCyc:GLYCOGENSYN-RXN|EC:2.4.1.21 molecular_function owl:Class
GO:0043816 biolink:NamedThing phosphoserine-tRNA(Cys) ligase activity Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys). got7fsn_ti O-phosphoseryl-tRNA(Cys) synthetase activity|phosphoserine--tRNA(Cys) ligase activity|phosphoserine-tRNACys ligase activity|SepRS EC:6.1.1.27|RHEA:25678 molecular_function owl:Class
GO:0033913 biolink:NamedThing glucan endo-1,2-beta-glucosidase activity Catalysis of the random hydrolysis of (1->2)-glucosidic linkages in (1->2)-beta-D-glucans. got7fsn_ti endo-(1->2)-beta-D-glucanase activity|beta-D-1,2-glucanase activity|1,2-beta-D-glucan glucanohydrolase activity|endo-1,2-beta-glucanase activity EC:3.2.1.71|MetaCyc:3.2.1.71-RXN molecular_function owl:Class
GO:0050066 biolink:NamedThing lysine 2,3-aminomutase activity Catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate. got7fsn_ti L-lysine 2,3-aminomutase activity EC:5.4.3.2|KEGG_REACTION:R00461|RHEA:19177|MetaCyc:LYSINE-23-AMINOMUTASE-RXN molecular_function owl:Class
GO:0071921 biolink:NamedThing cohesin loading The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA. got7fsn_ti cohesin association with chromatin|cohesin localisation to chromatin|cohesin localization to chromatin mah 2010-09-28T11:07:26Z biological_process owl:Class
GO:0071168 biolink:NamedThing protein localization to chromatin Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. got7fsn_ti protein localisation to chromatin mah 2009-11-20T11:51:20Z biological_process owl:Class
GO:0035053 biolink:NamedThing dorsal vessel heart proper cell fate commitment The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0018001 biolink:NamedThing N-terminal peptidyl-valine acetylation The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine. got7fsn_ti RESID:AA0054 biological_process owl:Class
GO:0097508 biolink:NamedThing xanthine DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated guanine (xanthine). got7fsn_ti xanthine-DNA glycosylase activity pr 2013-09-26T16:03:10Z molecular_function owl:Class
GO:0035996 biolink:NamedThing rhabdomere microvillus Thin cylindrical membrane-covered projection on the surface of a rhabdomere. got7fsn_ti bf 2011-09-01T02:18:30Z cellular_component owl:Class
GO:0140397 biolink:NamedThing versiconal hemiacetal acetate esterase activity Catalyzes the reactions: versiconal hemiacetal acetate + H(2)O <=> versiconal + acetate, as well as versiconol acetate + H(2)O <=> versiconol + acetate. got7fsn_ti pg 2019-11-29T10:14:17Z MetaCyc:RXN-9488|EC:3.1.1.94|MetaCyc:RXN-9493|RHEA:35715 molecular_function owl:Class
GO:0018321 biolink:NamedThing protein glucuronylation The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose. got7fsn_ti protein amino acid glucuronylation biological_process owl:Class
GO:0050230 biolink:NamedThing purine imidazole-ring cyclase activity Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O. got7fsn_ti DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing)|DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming)|DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming) MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN|EC:4.3.2.4 molecular_function owl:Class
GO:0030614 biolink:NamedThing oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide. got7fsn_ti oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor EC:1.20.4.- molecular_function owl:Class
GO:0030613 biolink:NamedThing oxidoreductase activity, acting on phosphorus or arsenic in donors Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors EC:1.20.-.- molecular_function owl:Class
GO:0072252 biolink:NamedThing metanephric juxtaglomerulus cell development The process whose specific outcome is the progression of a metanephric juxtaglomerulus cell over time, from its formation to the mature structure. got7fsn_ti mah 2010-03-19T03:55:31Z biological_process owl:Class
GO:0072142 biolink:NamedThing juxtaglomerulus cell development The process whose specific outcome is the progression of a juxtaglomerulus cell over time, from its formation to the mature structure. got7fsn_ti mah 2010-02-24T01:42:53Z biological_process owl:Class
GO:0032622 biolink:NamedThing interleukin-19 production The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-19 biosynthetic process|IL-19 secretion|ZMDA1 secretion|interleukin-19 secretion|IL-19 production GO:0042236|GO:0072617 biological_process owl:Class
GO:0032484 biolink:NamedThing Ral protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state. got7fsn_ti biological_process owl:Class
GO:0060050 biolink:NamedThing positive regulation of protein glycosylation Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. got7fsn_ti positive regulation of protein amino acid glycosylation biological_process owl:Class
GO:0071502 biolink:NamedThing cellular response to temperature stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. got7fsn_ti cellular response to thermal stimulus mah 2009-12-18T02:56:45Z biological_process owl:Class
GO:0007436 biolink:NamedThing larval salivary gland morphogenesis The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized. got7fsn_ti biological_process owl:Class
GO:0034064 biolink:NamedThing Tor2-Mei2-Ste11 complex A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast. got7fsn_ti cellular_component owl:Class
GO:0050208 biolink:NamedThing polysialic-acid O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9. got7fsn_ti acetyl-CoA:polysialic-acid O-acetyltransferase activity EC:2.3.1.136|MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN|RHEA:11604 molecular_function owl:Class
GO:0035903 biolink:NamedThing cellular response to immobilization stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. got7fsn_ti cellular response to immobilisation stress|cellular response to restraint stress bf 2011-06-22T09:47:44Z biological_process owl:Class
GO:0106103 biolink:NamedThing COPII vesicles tethering complex A protein complex that resides in the cis-golgi membrane and plays a role in the tethering of COPII vesicles, through an interaction with vesicle tethering proteins (p115 in H. Sapiens and Uso1 S. cerevisiae), granting the cis-Golgi and endoplasmic reticulum to Golgi vesicle-mediated transport. It is composed by GRASP65 and GM130 protein in H. sapiens and by Bug1 and Grh1 proteins in S. cerevisiae. got7fsn_ti GRASP65-GM130 complex|Bug1-Grh1 complex hjd 2018-02-15T23:36:12Z cellular_component owl:Class
GO:0099023 biolink:NamedThing vesicle tethering complex Any protein complex that plays a role in vesicle tethering. got7fsn_ti cellular_component owl:Class
GO:0102237 biolink:NamedThing ATP:farnesol kinase activity Catalysis of the reaction: 2-trans,-6-trans-farnesol + ATP = 2-trans,-6-trans-farnesyl monophosphate + ADP + H+. got7fsn_ti ATP-dependent farnesol kinase activity https://github.com/geneontology/go-ontology/issues/21619 RHEA:61656|MetaCyc:RXN-12304 molecular_function owl:Class
GO:0004730 biolink:NamedThing pseudouridylate synthase activity Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate. got7fsn_ti uracil hydro-lyase (adding D-ribose 5-phosphate)|5-ribosyluracil 5-phosphate synthetase activity|pseudouridylate synthetase activity|uracil hydrolyase activity|pseudouridine-5'-phosphate glycosidase activity|psiUMP synthetase activity|pseudouridine monophosphate synthase activity|pseudouridylic acid synthetase activity|uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)|pseudouridine monophosphate synthetase activity Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine. RHEA:18337|KEGG_REACTION:R01055|EC:4.2.1.70|MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN molecular_function owl:Class
GO:0000048 biolink:NamedThing peptidyltransferase activity Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). got7fsn_ti peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity MetaCyc:PEPTIDYLTRANSFERASE-RXN|Reactome:R-HSA-156912|EC:2.3.2.12 molecular_function owl:Class
GO:0048179 biolink:NamedThing activin receptor complex A protein complex that acts as an activin receptor. Heterodimeric activin receptors, comprising one Type I activin receptor and one Type II receptor polypeptide, and heterotrimeric receptors have been observed. got7fsn_ti cellular_component owl:Class
GO:0035910 biolink:NamedThing ascending aorta morphogenesis The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:14:52Z biological_process owl:Class
GO:0051908 biolink:NamedThing double-stranded DNA 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a double-stranded DNA molecule. got7fsn_ti double-stranded DNA specific 5'-3' exodeoxyribonuclease activity molecular_function owl:Class
GO:0008309 biolink:NamedThing double-stranded DNA exodeoxyribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. got7fsn_ti double-stranded DNA specific exodeoxyribonuclease activity molecular_function owl:Class
GO:0086064 biolink:NamedThing cell communication by electrical coupling involved in cardiac conduction The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction. got7fsn_ti dph 2011-11-22T08:49:44Z biological_process owl:Class
GO:0039004 biolink:NamedThing specification of pronephric proximal tubule identity The process in which the proximal tubule of the pronephric nephron acquires its identity. got7fsn_ti bf 2010-07-02T09:30:30Z biological_process owl:Class
GO:0072082 biolink:NamedThing specification of proximal tubule identity The process in which the proximal tubule of the kidney nephron acquires its identity. got7fsn_ti mah 2010-02-01T02:44:34Z biological_process owl:Class
GO:1901479 biolink:NamedThing benomyl transmembrane transporter activity Enables the transfer of benomyl from one side of a membrane to the other. got7fsn_ti benomyl transporter activity tb 2012-10-04T23:21:10Z GO:0015242 molecular_function owl:Class
GO:0018029 biolink:NamedThing peptidyl-lysine palmitoylation The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine. got7fsn_ti RESID:AA0077 biological_process owl:Class
GO:0097584 biolink:NamedThing dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p. got7fsn_ti Pmt5p-Pmt2p complex pr 2014-03-02T18:17:22Z cellular_component owl:Class
GO:0031502 biolink:NamedThing dolichyl-phosphate-mannose-protein mannosyltransferase complex A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies. got7fsn_ti PMT family mannosyltransferase complex|protein O-mannosyltransferase complex Note that GO:0004169 'dolichyl-phosphate-mannose-protein mannosyltransferase activity' (part of protein O-linked mannosylation) has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. cellular_component owl:Class
GO:0044170 biolink:NamedThing host cell smooth endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface. got7fsn_ti host smooth endoplasmic reticulum jl 2009-09-04T11:33:29Z cellular_component owl:Class
GO:0005521 biolink:NamedThing lamin binding Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. got7fsn_ti lamin/chromatin binding molecular_function owl:Class
GO:0004345 biolink:NamedThing glucose-6-phosphate dehydrogenase activity Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. got7fsn_ti D-glucose 6-phosphate dehydrogenase activity|Entner-doudoroff enzyme|glucose 6-phosphate dehydrogenase (NADP) activity|6-phosphoglucose dehydrogenas|G6PD activity|GDH|glucose-6-phosphate 1-dehydrogenase activity|NADP-glucose-6-phosphate dehydrogenase activity|6-phosphoglucose dehydrogenase activity|zwischenferment|G6PDH|Zwischenferment|D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity|NADP-dependent glucose 6-phosphate dehydrogenase activity RHEA:15841|MetaCyc:GLU6PDEHYDROG-RXN|EC:1.1.1.49|Reactome:R-HSA-70377 molecular_function owl:Class
GO:0048331 biolink:NamedThing axial mesoderm structural organization The process that contributes to the act of creating the structural organization of the axial mesoderm. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti axial mesoderm structural organisation biological_process owl:Class
GO:0048338 biolink:NamedThing mesoderm structural organization The process that contributes to the act of creating the structural organization of the mesoderm. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti mesoderm structural organisation biological_process owl:Class
GO:0052696 biolink:NamedThing flavonoid glucuronidation The modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor. got7fsn_ti flavonoid glucuronoside biosynthetic process|flavonoid glucuronide biosynthetic process|flavonoid glucuronoside biosynthesis|flavonoid glucuronide biosynthesis ai 2011-07-27T05:37:44Z biological_process owl:Class
GO:0042379 biolink:NamedThing chemokine receptor binding Binding to a chemokine receptor. got7fsn_ti chemokine receptor ligand molecular_function owl:Class
GO:0010076 biolink:NamedThing maintenance of floral meristem identity The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. got7fsn_ti biological_process owl:Class
GO:0019978 biolink:NamedThing interleukin-3 binding Binding to interleukin-3. got7fsn_ti IL-3 binding molecular_function owl:Class
GO:0006596 biolink:NamedThing polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. got7fsn_ti polyamine biosynthesis|polyamine anabolism|polyamine formation|polyamine synthesis MetaCyc:POLYAMSYN-PWY biological_process owl:Class
GO:0071371 biolink:NamedThing cellular response to gonadotropin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. got7fsn_ti cellular response to gonadotrophin stimulus mah 2009-12-11T03:14:35Z biological_process owl:Class
GO:0052817 biolink:NamedThing very long chain acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18. got7fsn_ti very long-chain acyl coenzyme A hydrolase activity|very long-chain hydrolase activity|very long-chain-acyl-CoA hydrolase activity|very long-chain acyl-thioester hydrolase activity ai 2011-10-27T12:18:28Z molecular_function owl:Class
GO:0052816 biolink:NamedThing long-chain acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length. got7fsn_ti long-chain acyl-thioester hydrolase activity|long-chain hydrolase activity|long-chain acyl coenzyme A hydrolase activity|long-chain-acyl-CoA hydrolase activity ai 2011-10-25T05:31:11Z molecular_function owl:Class
GO:0044522 biolink:NamedThing envenomation resulting in myocyte killing in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism. got7fsn_ti envenomation resulting in myocyte killing causing muscle damage in other organism jl 2012-02-27T12:33:57Z biological_process owl:Class
GO:0044521 biolink:NamedThing envenomation resulting in muscle damage in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism. got7fsn_ti jl 2012-02-27T12:31:08Z biological_process owl:Class
GO:0060938 biolink:NamedThing epicardium-derived cardiac fibroblast cell differentiation The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T01:28:03Z biological_process owl:Class
GO:0060935 biolink:NamedThing cardiac fibroblast cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T01:20:04Z biological_process owl:Class
GO:1990135 biolink:NamedThing flavonoid sulfotransferase activity Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative. got7fsn_ti tb 2013-06-28T22:07:27Z molecular_function owl:Class
GO:0030876 biolink:NamedThing interleukin-20 receptor complex A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits. got7fsn_ti IL-20 receptor complex cellular_component owl:Class
GO:0035214 biolink:NamedThing eye-antennal disc development Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps. got7fsn_ti biological_process owl:Class
GO:0043675 biolink:NamedThing sculpture element The third layer of the sexine. got7fsn_ti cellular_component owl:Class
GO:0060054 biolink:NamedThing positive regulation of epithelial cell proliferation involved in wound healing Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury. got7fsn_ti biological_process owl:Class
GO:0050679 biolink:NamedThing positive regulation of epithelial cell proliferation Any process that activates or increases the rate or extent of epithelial cell proliferation. got7fsn_ti upregulation of epithelial cell proliferation|activation of epithelial cell proliferation|up-regulation of epithelial cell proliferation|stimulation of epithelial cell proliferation|up regulation of epithelial cell proliferation biological_process owl:Class
GO:0000791 biolink:NamedThing euchromatin A dispersed and relatively uncompacted form of chromatin. got7fsn_ti nuclear euchromatin GO:0005719 NIF_Subcellular:sao445485807|Wikipedia:Euchromatin cellular_component owl:Class
GO:0018410 biolink:NamedThing C-terminal protein amino acid modification The alteration of the C-terminal amino acid residue in a protein. got7fsn_ti peptide or protein carboxyl-terminal blocking|peptide/protein carboxyl-terminal blocking biological_process owl:Class
GO:0043687 biolink:NamedThing post-translational protein modification The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. got7fsn_ti PTM|posttranslational amino acid modification|posttranslational protein modification|post-translational amino acid modification|posttranslational modification|post-translational modification This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term. Wikipedia:Posttranslational_modification biological_process owl:Class
GO:0008892 biolink:NamedThing guanine deaminase activity Catalysis of the reaction: guanine + H2O = xanthine + NH3. got7fsn_ti guanine aminohydrolase activity|guanine aminase activity|guanase activity|GAH activity Reactome:R-HSA-74255|EC:3.5.4.3|RHEA:14665|MetaCyc:GUANINE-DEAMINASE-RXN molecular_function owl:Class
GO:0052496 biolink:NamedThing occlusion by host of symbiont xylem The process in which an organism reduces the flow of fluid within the symbiont xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0052497 biolink:NamedThing occlusion by organism of xylem in other organism involved in symbiotic interaction The process in which an organism reduces the flow of fluid within the xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves, of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti occlusion by organism of xylem in other organism during symbiotic interaction biological_process owl:Class
GO:0004070 biolink:NamedThing aspartate carbamoyltransferase activity Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate. got7fsn_ti aspartic transcarbamylase activity|aspartic acid transcarbamoylase activity|carbamoylaspartotranskinase activity|L-aspartate transcarbamoylase activity|aspartate transcarbamoylase activity|aspartic carbamyltransferase activity|carbamoyl-phosphate:L-aspartate carbamoyltransferase activity|aspartate transcarbamylase activity|L-aspartate transcarbamylase activity|aspartate carbamyltransferase activity|ATCase activity|carbamylaspartotranskinase activity MetaCyc:ASPCARBTRANS-RXN|RHEA:20013|EC:2.1.3.2|KEGG_REACTION:R01397|Reactome:R-HSA-73573 molecular_function owl:Class
GO:0075330 biolink:NamedThing positive regulation of arbuscule formation for nutrient acquisition from host Any process that activates or increases the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0075329 biolink:NamedThing regulation of arbuscule formation for nutrient acquisition from host Any process that modulates the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0071099 biolink:NamedThing alphaV-beta6 integrin-TGFbeta-3 complex A protein complex that consists of an alphaV-beta6 integrin complex bound to transforming growth factor beta-3 (TGFbeta-3). got7fsn_ti ITGAV-ITGB6-TFGB3 complex mah 2009-11-06T04:52:27Z cellular_component owl:Class
GO:0043774 biolink:NamedThing coenzyme F420-2 alpha-glutamyl ligase activity Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate. got7fsn_ti F420-2 alpha-glutamyl ligase activity EC:6.3.2.32|RHEA:42332 molecular_function owl:Class
GO:0061967 biolink:NamedThing establishment of left sidedness The initial formation of the type asymmetry in an organism's body plan or part of an organism that established the pattern characteristic to its left side. got7fsn_ti dph 2018-02-12T16:32:41Z biological_process owl:Class
GO:0061966 biolink:NamedThing establishment of left/right asymmetry The initial formation of the type asymmetry in an organism's body plan or part of an organism with respect to the left and right halves. got7fsn_ti dph 2018-02-12T16:27:20Z biological_process owl:Class
GO:0051700 biolink:NamedThing fructosyl-amino acid oxidase activity Catalysis of the reaction: fructosyl-amino acid + O2 = corresponding amino acid + glucosone + H2O2. got7fsn_ti FAOD activity molecular_function owl:Class
GO:0072114 biolink:NamedThing pronephros morphogenesis The process in which the anatomical structures of the pronephros are generated and organized. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. got7fsn_ti pronephric kidney morphogenesis mah 2010-02-22T11:12:15Z biological_process owl:Class
GO:0006639 biolink:NamedThing acylglycerol metabolic process The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. got7fsn_ti acylglycerol metabolism|glyceride metabolism|glyceride metabolic process biological_process owl:Class
GO:0039668 biolink:NamedThing viral entry into host cell via pilus basal pore The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way. got7fsn_ti filamentous viral entry into host cell via pilus retraction bf 2013-09-04T14:33:18Z biological_process owl:Class
GO:0039667 biolink:NamedThing viral entry into host cell via pilus retraction The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus. got7fsn_ti This method of entry into the cell differs between viruses; filamentous bacteriophages have rod-shaped virions which attach to the tip of the pilus; after retraction of the pilus with the virion attached, the genome can enter the host cell through the pilus basal pore. For icosahedral viruses, retraction of the pilus brings the virus in contact with the cell membrane and the genome can enter the cell via membrane fusion or genome injection. In GO, viral entry begins after viral attachment; for pilus-attachment proteins see instead: viral attachment to host cell pilus ; GO:0039666. bf 2013-09-04T14:32:19Z biological_process owl:Class
GO:0033843 biolink:NamedThing xyloglucan 6-xylosyltransferase activity Catalysis of the transfer of an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-1,6-D-xylosyl-D-glucose linkage. got7fsn_ti uridine diphosphoxylose-xyloglucan 6alpha-xylosyltransferase activity|xyloglucan 6-alpha-D-xylosyltransferase activity|UDP-D-xylose:xyloglucan 1,6-alpha-D-xylosyltransferase activity EC:2.4.2.39|MetaCyc:2.4.2.39-RXN molecular_function owl:Class
GO:1990438 biolink:NamedThing U6 2'-O-snRNA methylation The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule. got7fsn_ti mah 2014-07-31T12:04:21Z biological_process owl:Class
GO:1990437 biolink:NamedThing snRNA 2'-O-methylation The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule. got7fsn_ti mah 2014-07-31T11:58:18Z biological_process owl:Class
GO:0033528 biolink:NamedThing S-methylmethionine cycle A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level. got7fsn_ti MetaCyc:PWY-5441 biological_process owl:Class
GO:0033477 biolink:NamedThing S-methylmethionine metabolic process The chemical reactions and pathways involving S-methyl-methionine (SMM). SMM can be converted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle. got7fsn_ti S-methylmethionine metabolism biological_process owl:Class
GO:0009270 biolink:NamedThing response to humidity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere. got7fsn_ti biological_process owl:Class
GO:0008420 biolink:NamedThing RNA polymerase II CTD heptapeptide repeat phosphatase activity Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate. got7fsn_ti CTD phosphatase activity|RNA polymerase II carboxy-terminal domain phosphatase activity molecular_function owl:Class
GO:0001570 biolink:NamedThing vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. got7fsn_ti vascular morphogenesis Wikipedia:Vasculogenesis biological_process owl:Class
GO:0006465 biolink:NamedThing signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. got7fsn_ti leader peptide processing biological_process owl:Class
GO:0044291 biolink:NamedThing cell-cell contact zone Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle. got7fsn_ti cell cell contact zone jl 2010-02-04T02:42:54Z NIF_Subcellular:sao1299635018 cellular_component owl:Class
GO:0005911 biolink:NamedThing cell-cell junction A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. got7fsn_ti intercellular junction NIF_Subcellular:sao1922892319 cellular_component owl:Class
GO:0050797 biolink:NamedThing thymidylate synthase (FAD) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+. got7fsn_ti FDTS activity|ThyX activity|Thy1 activity|5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase activity|flavin dependent thymidylate synthase activity MetaCyc:RXN-8850|RHEA:29043|EC:2.1.1.148|KEGG_REACTION:R06613 molecular_function owl:Class
GO:0042083 biolink:NamedThing 5,10-methylenetetrahydrofolate-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate. got7fsn_ti molecular_function owl:Class
GO:0018969 biolink:NamedThing thiocyanate metabolic process The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries. got7fsn_ti thiocyanic acid metabolic process|thiocyanate metabolism|thiocyanic acid metabolism UM-BBD_pathwayID:thc|MetaCyc:P581-PWY biological_process owl:Class
GO:0052613 biolink:NamedThing canthaxanthin 3-hydroxylase activity Catalysis of the reaction: canthaxanthin + a reduced electron acceptor + oxygen = adonirubin + an oxidized electron acceptor + H2O. got7fsn_ti carotene beta-ring hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity|beta-carotene hydroxylase activity MetaCyc:RXN-8186 molecular_function owl:Class
GO:0060051 biolink:NamedThing negative regulation of protein glycosylation Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. got7fsn_ti negative regulation of protein amino acid glycosylation biological_process owl:Class
GO:1901277 biolink:NamedThing tartrate biosynthetic process The chemical reactions and pathways resulting in the formation of tartrate. got7fsn_ti tartrate biosynthesis|tartrate anabolism|tartrate synthesis|tartrate formation yaf 2012-08-17T14:52:48Z biological_process owl:Class
GO:0021931 biolink:NamedThing rostral hindbrain neuronal precursor cell proliferation The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus. got7fsn_ti biological_process owl:Class
GO:0021924 biolink:NamedThing cell proliferation in external granule layer The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere. got7fsn_ti biological_process owl:Class
GO:0006777 biolink:NamedThing Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. got7fsn_ti molybdenum cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthesis|Moco biosynthesis|Mo-molybdopterin cofactor anabolism|Moco biosynthetic process|Mo-molybdopterin cofactor synthesis|Mo-molybdopterin cofactor formation MetaCyc:PWY-6823 biological_process owl:Class
GO:1990252 biolink:NamedThing Syp1 complex A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis. got7fsn_ti Syp1 dimer bhm 2013-12-09T14:43:00Z cellular_component owl:Class
GO:0007117 biolink:NamedThing budding cell bud growth The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. got7fsn_ti bud growth biological_process owl:Class
GO:2000260 biolink:NamedThing regulation of blood coagulation, common pathway Any process that modulates the frequency, rate or extent of blood coagulation, common pathway. got7fsn_ti mah 2010-11-23T11:42:40Z biological_process owl:Class
GO:0007596 biolink:NamedThing blood coagulation The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. got7fsn_ti blood clotting Wikipedia:Coagulation biological_process owl:Class
GO:0098910 biolink:NamedThing regulation of atrial cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti tb 2011-11-10T08:49:13Z biological_process owl:Class
GO:0072173 biolink:NamedThing metanephric tubule morphogenesis The process in which the anatomical structures of a metanephric tubule are generated and organized from an epithelium. A metanephric tubule is an epithelial tube that is part of the metanephros. got7fsn_ti mah 2010-02-26T02:06:42Z biological_process owl:Class
GO:0072170 biolink:NamedThing metanephric tubule development The progression of a metanephric tubule over time, from its initial formation to the mature structure. A metanephric tubule is an epithelial tube that is part of the metanephros. got7fsn_ti mah 2010-02-26T01:58:18Z biological_process owl:Class
GO:1990331 biolink:NamedThing Hpa2 acetyltransferase complex A tetrameric protein complex capable of acetyltransferase activity. It can catalyze the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histone H-3, histone H-4, or on polyamines. The complex is also capable of acetylating certain small basic proteins. The two Hpa2 dimers that make up the tetramer are held together by interactions between the bound acetyl-CoA molecules. got7fsn_ti bhm 2014-03-17T10:18:23Z cellular_component owl:Class
GO:0060271 biolink:NamedThing cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. got7fsn_ti cilium biogenesis|cilium formation|microtubule-based flagellum assembly|ciliogenesis|cilium organization|cilium assembly|cilium morphogenesis Note that we deem cilium and microtubule-based flagellum to be equivalent. GO:0042384 Reactome:R-HSA-5617833.2 biological_process owl:Class
NCBITaxon:2759 biolink:NamedThing got7fsn_ti owl:Class
GO:2000551 biolink:NamedThing regulation of T-helper 2 cell cytokine production Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production. got7fsn_ti regulation of Th2 cell cytokine production ebc 2011-04-03T07:32:47Z biological_process owl:Class
GO:0004913 biolink:NamedThing interleukin-4 receptor activity Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-4 receptor activity|IL-4R molecular_function owl:Class
GO:0021822 biolink:NamedThing negative regulation of cell motility involved in cerebral cortex radial glia guided migration The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex. got7fsn_ti negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration|inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration|negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration|down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration|down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration|downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration biological_process owl:Class
GO:0008347 biolink:NamedThing glial cell migration The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. got7fsn_ti glia cell migration GO:0043359 biological_process owl:Class
GO:0001072 biolink:NamedThing transcription antitermination factor activity, RNA binding Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein. got7fsn_ti RNA binding transcription antitermination factor activity krc 2010-10-21T04:48:17Z molecular_function owl:Class
GO:0031564 biolink:NamedThing transcription antitermination Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s). got7fsn_ti transcriptional readthrough biological_process owl:Class
GO:0021801 biolink:NamedThing cerebral cortex radial glia-guided migration The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex. got7fsn_ti glial-guided locomotion|cerebral cortex radial glia guided migration|cerebral cortex radial glia-dependent cell migration biological_process owl:Class
CL:0000125 biolink:NamedThing got7fsn_ti owl:Class
NCBITaxon:2 biolink:NamedThing got7fsn_ti owl:Class
GO:0097278 biolink:NamedThing complement-dependent cytotoxicity Cell killing caused by the membrane attack complex formed following complement activation. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18715 pr 2012-03-22T05:04:04Z biological_process owl:Class
GO:0006956 biolink:NamedThing complement activation Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. got7fsn_ti complement response|complement cascade|complement activity biological_process owl:Class
GO:0044543 biolink:NamedThing envenomation resulting in zymogen activation in other organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form. got7fsn_ti jl 2012-03-22T11:52:56Z biological_process owl:Class
GO:0048612 biolink:NamedThing post-embryonic ectodermal digestive tract development The process, occurring during the post-embryonic phase, whose specific outcome is the progression of the ectodermal gut over time, from its formation to the mature structure. got7fsn_ti post-embryonic ectodermal gut development biological_process owl:Class
GO:0030672 biolink:NamedThing synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle. got7fsn_ti cellular_component owl:Class
GO:0043673 biolink:NamedThing sexine The outer, sculptured layer of the exine, which lies above the nexine. got7fsn_ti Note that the sexine sometimes consists of 5 layers, but of those, 3 layers are the most common (sexine 1 = columellae; sexine 2 = tectum; sexine 3 = sculpture elements). Sexine is distinguished on purely morphological criteria; compare with 'ectexine ; GO:0043669'. See also 'nexine ; GO:0043672'. cellular_component owl:Class
GO:0043668 biolink:NamedThing exine The outer layer of the pollen grain wall which is composed primarily of sporopollenin. got7fsn_ti Note that the exine is highly resistant to strong acids and bases. cellular_component owl:Class
GO:0048919 biolink:NamedThing posterior lateral line neuromast development The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals. got7fsn_ti biological_process owl:Class
GO:0005756 biolink:NamedThing mitochondrial proton-transporting ATP synthase, central stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis. got7fsn_ti cellular_component owl:Class
GO:0000275 biolink:NamedThing mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. got7fsn_ti proton-transporting ATP synthase complex, catalytic core F(1)|hydrogen-transporting ATP synthase, F1 sector See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. cellular_component owl:Class
GO:0090104 biolink:NamedThing pancreatic epsilon cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin. got7fsn_ti pancreatic E cell differentiation tb 2009-11-18T11:48:52Z biological_process owl:Class
GO:0031018 biolink:NamedThing endocrine pancreas development The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin. got7fsn_ti biological_process owl:Class
GO:0003164 biolink:NamedThing His-Purkinje system development The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles. got7fsn_ti dph 2009-10-01T02:07:12Z biological_process owl:Class
GO:0003161 biolink:NamedThing cardiac conduction system development The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. got7fsn_ti heart conduction system development|cardiac impulse conducting system development dph 2009-10-01T01:57:16Z biological_process owl:Class
GO:0036071 biolink:NamedThing N-glycan fucosylation The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains. got7fsn_ti glycoprotein fucosylation bf 2011-12-15T04:54:24Z biological_process owl:Class
GO:0031633 biolink:NamedThing xanthophore A chromatophore containing yellow pigment. got7fsn_ti Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells. cellular_component owl:Class
NCBITaxon:Union_0000004 biolink:NamedThing got7fsn_ti owl:Class
GO:0002802 biolink:NamedThing positive regulation of antifungal peptide secretion Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion. got7fsn_ti upregulation of antifungal peptide secretion|activation of antifungal peptide secretion|up-regulation of antifungal peptide secretion|stimulation of antifungal peptide secretion|up regulation of antifungal peptide secretion biological_process owl:Class
GO:0002781 biolink:NamedThing antifungal peptide production The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
NCBITaxon:2864 biolink:NamedThing got7fsn_ti owl:Class
GO:0080001 biolink:NamedThing mucilage extrusion from seed coat The process in which seed mucilage expands through hydration and breaks the outer cell wall that encapsulates the whole seed upon imbibition. Mucilage, mainly composed of pectins, is formed during seed development and deposited into the apoplast underneath the outer wall of the seed coat. got7fsn_ti secretion of mucilage from seed coat|mucilage release from seed coat biological_process owl:Class
GO:1990180 biolink:NamedThing mitochondrial tRNA 3'-end processing The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion. got7fsn_ti tRNA 3'-end processing in mitochondria|tRNA 3' processing in mitochondrion|tRNA 3' processing in mitochondria mah 2013-08-30T16:17:36Z biological_process owl:Class
GO:0033290 biolink:NamedThing eukaryotic 48S preinitiation complex A protein complex composed of the small ribosomal subunit, eIF3, eIF1A, methionyl-initiatior methionine and a capped mRNA. The complex is initially positioned at the 5'-end of the capped mRNA. got7fsn_ti eukaryotic 48S initiation complex|eukaryotic 48S pre-initiation complex GO:0016283 cellular_component owl:Class
GO:0022627 biolink:NamedThing cytosolic small ribosomal subunit The small subunit of a ribosome located in the cytosol. got7fsn_ti prokaryotic small ribosomal subunit|40S ribosomal subunit|eukaryotic ribosomal SSU|30S ribosomal subunit GO:0009283|GO:0030499|GO:0030873|GO:0005843 cellular_component owl:Class
GO:0015095 biolink:NamedThing magnesium ion transmembrane transporter activity Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other. got7fsn_ti Reactome:R-HSA-5336454|Reactome:R-HSA-5339538|Reactome:R-HSA-5336466|RHEA:29827|Reactome:R-HSA-5339528|Reactome:R-HSA-442661|Reactome:R-HSA-5336453 molecular_function owl:Class
GO:1903830 biolink:NamedThing magnesium ion transmembrane transport The directed movement of magnesium ion across a membrane. got7fsn_ti mcc 2015-01-21T17:38:30Z biological_process owl:Class
GO:1905080 biolink:NamedThing negative regulation of cerebellar neuron development Any process that stops, prevents or reduces the frequency, rate or extent of cerebellar neuron development. got7fsn_ti downregulation of cerebellar neuron development|inhibition of cerebellar neuron development|down-regulation of cerebellar neuron development|down regulation of cerebellar neuron development hjd 2016-03-24T19:45:26Z biological_process owl:Class
GO:0005816 biolink:NamedThing spindle pole body The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome. got7fsn_ti SPB Wikipedia:Spindle_pole_body cellular_component owl:Class
GO:0005604 biolink:NamedThing basement membrane A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers. got7fsn_ti basal lamina|basement lamina|lamina densa Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. GO:0005605|GO:0008003 Wikipedia:Basement_membrane cellular_component owl:Class
GO:0000354 biolink:NamedThing cis assembly of pre-catalytic spliceosome Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner. got7fsn_ti spliceosomal A2-1 complex biosynthesis|spliceosomal A2-1 complex formation|cis assembly of U2-type pre-catalytic spliceosome|formation of spliceosomal B1 complex|cis assembly of U12-type pre-catalytic spliceosome|formation of spliceosomal A2-1 complex|spliceosomal B1 complex biosynthesis|spliceosomal B1 complex formation Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals). GO:0000360|GO:0000361 biological_process owl:Class
GO:0000245 biolink:NamedThing spliceosomal complex assembly The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. got7fsn_ti spliceosome assembly biological_process owl:Class
GO:0001844 biolink:NamedThing protein insertion into mitochondrial membrane involved in apoptotic signaling pathway The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway. got7fsn_ti protein insertion into mitochondrial membrane involved in induction of apoptosis|protein insertion into mitochondrial membrane during induction of apoptosis|protein insertion into mitochondrion membrane during induction of apoptosis|insertion of proteins into mitochondrial membranes during the induction of apoptosis Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program. biological_process owl:Class
GO:0070931 biolink:NamedThing Golgi-associated vesicle lumen The volume enclosed by the membrane of a Golgi-associated vesicle. got7fsn_ti mah 2009-09-16T04:26:50Z cellular_component owl:Class
NCBITaxon:4751 biolink:NamedThing got7fsn_ti owl:Class
GO:0042628 biolink:NamedThing mating plug formation The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males. got7fsn_ti copulatory plug formation|mating plug deposition|copulatory plug deposition|copulatory plug biosynthesis biological_process owl:Class
GO:0007320 biolink:NamedThing insemination The introduction of semen or sperm into the genital tract of a female. got7fsn_ti Wikipedia:Insemination biological_process owl:Class
GO:0048586 biolink:NamedThing regulation of long-day photoperiodism, flowering Any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. got7fsn_ti biological_process owl:Class
NCBITaxon:3398 biolink:NamedThing got7fsn_ti owl:Class
GO:0010019 biolink:NamedThing chloroplast-nucleus signaling pathway The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis. got7fsn_ti chloroplast-nucleus signalling pathway biological_process owl:Class
NCBITaxon:33090 biolink:NamedThing got7fsn_ti owl:Class
GO:0015627 biolink:NamedThing type II protein secretion system complex A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. got7fsn_ti T2SS-associated complexes|general secretion pathway-associated complex|main terminal branch|Sec-dependent secretion system-associated complex|MTB Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. cellular_component owl:Class
GO:1990779 biolink:NamedThing glycoprotein Ib-IX-V complex A transmembrane signalling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation. got7fsn_ti GPIb-IX-V complex|CD42|GPIb-V-IX complex An example of this is GB1BA in human (P07359) in PMID:1730602 (inferred from direct assay). bhm 2015-06-23T11:22:12Z cellular_component owl:Class
NCBITaxon:33208 biolink:NamedThing got7fsn_ti owl:Class
GO:0035047 biolink:NamedThing centrosomal and pronuclear rotation The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion. got7fsn_ti biological_process owl:Class
GO:0007338 biolink:NamedThing single fertilization The union of male and female gametes to form a zygote. got7fsn_ti zygote formation|zygote biosynthesis biological_process owl:Class
GO:0015134 biolink:NamedThing hexuronate transmembrane transporter activity Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6. got7fsn_ti hexuronide transmembrane transporter activity GO:0015163 molecular_function owl:Class
GO:0090093 biolink:NamedThing regulation of fungal-type cell wall beta-glucan biosynthetic process Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells. got7fsn_ti tb 2009-11-13T10:10:38Z biological_process owl:Class
GO:0060395 biolink:NamedThing SMAD protein signal transduction The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell. got7fsn_ti biological_process owl:Class
GO:0072120 biolink:NamedThing pronephros maturation A developmental process, independent of morphogenetic (shape) change, that is required for the pronephros to attain its fully functional state. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. got7fsn_ti pronephric kidney maturation mah 2010-02-22T11:25:48Z biological_process owl:Class
GO:0048793 biolink:NamedThing pronephros development The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. got7fsn_ti pronephric kidney development biological_process owl:Class
GO:0051298 biolink:NamedThing centrosome duplication The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. got7fsn_ti centrosome replication biological_process owl:Class
GO:0000399 biolink:NamedThing cellular bud neck septin structure Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle. got7fsn_ti cellular_component owl:Class
GO:0005935 biolink:NamedThing cellular bud neck The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding. got7fsn_ti cellular_component owl:Class
GO:0097597 biolink:NamedThing ventral disc Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence. got7fsn_ti ventral adhesive disc|ventral disk|adhesive disc Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-04-03T11:29:58Z cellular_component owl:Class
GO:0031391 biolink:NamedThing Elg1 RFC-like complex A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. got7fsn_ti RFC (Elg1)|Elg1-RLC|Elg1-RFC cellular_component owl:Class
GO:0005890 biolink:NamedThing sodium:potassium-exchanging ATPase complex Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior. got7fsn_ti sodium pump|sodium/potassium-exchanging ATPase complex cellular_component owl:Class
GO:0080112 biolink:NamedThing seed growth The increase in size or mass of a seed. A seed is a propagating organ formed in the reproductive cycle of a spermatophyte, derived from the ovule and enclosing an embryo. got7fsn_ti dhl 2009-04-27T02:52:07Z biological_process owl:Class
GO:0097592 biolink:NamedThing ventral disc overlap zone A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself). got7fsn_ti ventral disk overlap zone|overlap zone Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-04-03T11:12:50Z cellular_component owl:Class
GO:1905756 biolink:NamedThing regulation of primary cell septum biogenesis Any process that modulates the frequency, rate or extent of primary cell septum biogenesis. got7fsn_ti vw 2016-12-12T18:09:50Z biological_process owl:Class
GO:0060298 biolink:NamedThing positive regulation of sarcomere organization Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. got7fsn_ti positive regulation of sarcomere organisation biological_process owl:Class
GO:0007293 biolink:NamedThing germarium-derived egg chamber formation Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
NCBITaxon:6656 biolink:NamedThing got7fsn_ti owl:Class
CL:0000071 biolink:NamedThing got7fsn_ti owl:Class
GO:0070558 biolink:NamedThing alphaM-beta2 integrin-CD63 complex A protein complex that consists of an alphaM-beta2 integrin complex bound to membrane protein CD63, a member of the tetraspan family. got7fsn_ti ITGAM-ITGB2-CD63 complex cellular_component owl:Class
GO:0036214 biolink:NamedThing contractile ring localization The process in which a contractile ring is assembled and/or maintained in a specific location. got7fsn_ti This term can be used to annotate localization of either bacterial or fungal contractile rings. bf 2012-04-26T02:58:50Z biological_process owl:Class
GO:0061640 biolink:NamedThing cytoskeleton-dependent cytokinesis A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton. got7fsn_ti dph 2014-08-22T14:21:35Z biological_process owl:Class
GO:0009656 biolink:NamedThing PSII associated light-harvesting complex II, peripheral complex Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light. got7fsn_ti cellular_component owl:Class
GO:0009507 biolink:NamedThing chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. got7fsn_ti Wikipedia:Chloroplast cellular_component owl:Class
GO:0007188 biolink:NamedThing adenylate cyclase-modulating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP). got7fsn_ti G protein signaling, coupled to cAMP nucleotide second messenger|G protein signaling, coupled to cyclic AMP nucleotide second messenger|G-protein signaling, coupled to cyclic AMP nucleotide second messenger|GPCR signaling pathway via cAMP second messenger|G protein signalling, coupled to cAMP nucleotide second messenger|G-protein signaling, coupled to cAMP nucleotide second messenger|GPCR signaling pathway via modulation of adenylate cyclase activity|G-protein signalling, coupled to cAMP nucleotide second messenger|adenylate cyclase-modulating GPCR signaling pathway|G-protein signalling, coupled to cyclic AMP nucleotide second messenger|G protein signalling, coupled to cyclic AMP nucleotide second messenger This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway ; GO:0010578. biological_process owl:Class
GO:0045761 biolink:NamedThing regulation of adenylate cyclase activity Any process that modulates the frequency, rate or extent of adenylate cyclase activity. got7fsn_ti adenylate cyclase regulator|regulation of adenylyl cyclase activity biological_process owl:Class
GO:2001234 biolink:NamedThing negative regulation of apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway. got7fsn_ti negative regulation of apoptotic signalling pathway pr 2011-11-24T01:20:54Z biological_process owl:Class
GO:0070118 biolink:NamedThing organellar chromatophore thylakoid membrane The lipid bilayer membrane of any thylakoid within an organellar chromatophore. got7fsn_ti Paulinella-type chromatophore thylakoid membrane cellular_component owl:Class
GO:0070116 biolink:NamedThing organellar chromatophore thylakoid A thylakoid located in an organellar chromatophore. got7fsn_ti Paulinella-type chromatophore thylakoid cellular_component owl:Class
GO:0015168 biolink:NamedThing glycerol transmembrane transporter activity Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. got7fsn_ti molecular_function owl:Class
GO:0015793 biolink:NamedThing glycerol transport The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. got7fsn_ti biological_process owl:Class
GO:0072282 biolink:NamedThing metanephric nephron tubule morphogenesis The process in which the anatomical structures of a metanephric nephron tubule are generated and organized. A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros. got7fsn_ti mah 2010-04-01T03:25:11Z biological_process owl:Class
GO:0048557 biolink:NamedThing embryonic digestive tract morphogenesis The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed. got7fsn_ti embryonic gut morphogenesis GO:0048558 biological_process owl:Class
GO:1904348 biolink:NamedThing negative regulation of small intestine smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction. got7fsn_ti down-regulation of small intestine smooth muscle contraction|inhibition of small intestine smooth muscle contraction|downregulation of small intestine smooth muscle contraction|down regulation of small intestine smooth muscle contraction sl 2015-06-11T21:37:40Z biological_process owl:Class
GO:0014831 biolink:NamedThing gastro-intestinal system smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract). got7fsn_ti biological_process owl:Class
GO:1901251 biolink:NamedThing positive regulation of lung goblet cell differentiation Any process that activates or increases the frequency, rate or extent of lung goblet cell differentiation. got7fsn_ti positive regulation of pulmonary goblet cell differentiation|upregulation of lung goblet cell differentiation|upregulation of pulmonary goblet cell differentiation|up regulation of lung goblet cell differentiation|activation of pulmonary goblet cell differentiation|activation of lung goblet cell differentiation|up-regulation of pulmonary goblet cell differentiation|up regulation of pulmonary goblet cell differentiation|up-regulation of lung goblet cell differentiation vk 2012-08-08T08:59:44Z biological_process owl:Class
GO:0009382 biolink:NamedThing imidazoleglycerol-phosphate synthase complex Complex that possesses imidazoleglycerol-phosphate synthase activity. got7fsn_ti imidazoleglycerol phosphate synthase complex See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'. cellular_component owl:Class
GO:0009332 biolink:NamedThing glutamate-tRNA ligase complex An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu). got7fsn_ti cellular_component owl:Class
GO:0002930 biolink:NamedThing trabecular meshwork development The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor. got7fsn_ti hjd 2012-04-19T04:50:06Z biological_process owl:Class
GO:0043010 biolink:NamedThing camera-type eye development The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. got7fsn_ti GO:0031075|GO:0001747 biological_process owl:Class
GO:0010008 biolink:NamedThing endosome membrane The lipid bilayer surrounding an endosome. got7fsn_ti endosomal membrane NIF_Subcellular:sao978443756 cellular_component owl:Class
GO:0072241 biolink:NamedThing metanephric DCT cell development The process whose specific outcome is the progression of a metanephric distal convoluted tubule cell over time, from its formation to the mature structure. got7fsn_ti metanephric distal convoluted tubule cell development mah 2010-03-19T03:26:44Z biological_process owl:Class
GO:0071507 biolink:NamedThing pheromone response MAPK cascade A MAPK cascade that is part of a pheromone response ending in conjugation with cellular fusion. got7fsn_ti conjugation with cellular fusion, MAPKKK cascade|MAPKKK cascade involved in conjugation with cellular fusion|MAPK signaling in response to pheromone|pheromone MAPK module|MAPKKK cascade involved in mating response|MAPK cascade involved in conjugation with cellular fusion|Fus3 signaling cascade mah 2010-01-05T01:43:47Z biological_process owl:Class
GO:0000750 biolink:NamedThing pheromone-dependent signal transduction involved in conjugation with cellular fusion A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti transduction of mating signal GO:0030454|GO:0007330 biological_process owl:Class
GO:0001609 biolink:NamedThing G protein-coupled adenosine receptor activity Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti A1 adenosine receptor activity, G-protein coupled|G protein coupled A1 adenosine receptor activity|adenosine receptor activity, G protein coupled|A1 adenosine receptor activity, G protein coupled|P1 receptor|A2A adenosine receptor activity, G-protein coupled|G protein coupled A2A adenosine receptor activity|G-protein-coupled A2A adenosine receptor activity|A2A adenosine receptor activity, G protein coupled|G protein coupled A2B adenosine receptor activity|G-protein-coupled A1 adenosine receptor activity|G-protein-coupled A3 adenosine receptor activity|A3 adenosine receptor activity, G protein coupled|A3 adenosine receptor activity, G-protein coupled|G-protein coupled adenosine receptor activity|G-protein-coupled A2B adenosine receptor activity|A2B adenosine receptor activity, G-protein coupled|adenosine nucleotide receptor|G protein coupled A3 adenosine receptor activity|A2B adenosine receptor activity, G protein coupled|G protein coupled adenosine receptor activity|adenosine receptor activity, G-protein coupled GO:0001611|GO:0001612|GO:0001610|GO:0008501|GO:0001613 molecular_function owl:Class
GO:0001973 biolink:NamedThing G protein-coupled adenosine receptor signaling pathway The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. got7fsn_ti adenosine receptor signaling pathway, G-protein coupled|adenosine receptor signalling pathway|P1 receptor signaling pathway|adenosine receptor signaling pathway biological_process owl:Class
GO:0098026 biolink:NamedThing virus tail, tube The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm. got7fsn_ti bacteriophage tail tube Applies in particular the Myoviridae bacteriophages. bm 2012-07-19T14:21:28Z cellular_component owl:Class
GO:0098015 biolink:NamedThing virus tail Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell. got7fsn_ti viral tail|bacteriophage tail Many bacteriophages with dsDNA genomes, or Caudovirales, have a tail. The viral tail can be short (Podoviridae), long and non-contractile (Siphoviridae) or long and contractile (Myoviridae). The tail is the channel through which the phage genome is injected into the host bacterial cell. bm 2012-07-18T17:04:46Z cellular_component owl:Class
GO:0000440 biolink:NamedThing core TFIIH complex portion of NEF3 complex The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). got7fsn_ti SSL2-core TFIIH complex portion of NEF3 complex GO:0000442 cellular_component owl:Class
GO:0044604 biolink:NamedThing ABC-type phytochelatin transporter activity Enables the directed movement of a phytochelatin from one side of a membrane to the other. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. got7fsn_ti phytochelatin transmembrane transporter activity|ATP-dependent phytochelatin transmembrane transporter activity|ABC-type phytochelatin transmembrane transporter activity|phytochelatin transmembrane transporter ATPase activity|cadystin transmembrane transporter activity|ATPase-coupled phytochelatin transmembrane transporter activity|phytochelatin transporter activity|cadystin transmembrane transporter ATPase activity|cadystin transporter activity https://github.com/geneontology/go-ontology/issues/14492 jl 2010-10-25T01:00:17Z GO:0071992|GO:0071991 molecular_function owl:Class
GO:0071994 biolink:NamedThing phytochelatin transmembrane transport The process in which a phytochelatin is transported across a membrane. Phytochelatins are a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. got7fsn_ti phytochelatin membrane transport|cadystin transmembrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-10-25T01:58:50Z biological_process owl:Class
NCBITaxon:6072 biolink:NamedThing got7fsn_ti owl:Class
GO:0061356 biolink:NamedThing regulation of Wnt protein secretion Any process that modulates the frequency, rate or extent of the controlled release of a Wnt protein from a cell. got7fsn_ti dph 2010-10-08T01:09:51Z biological_process owl:Class
GO:0007399 biolink:NamedThing nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. got7fsn_ti pan-neural process biological_process owl:Class
GO:0008558 biolink:NamedThing ABC-type guanine transporter activity Catalyses the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in). got7fsn_ti guanine ABC transporter|guanine-transporting ATPase activity|ATP-dependent guanine transmembrane transporter activity|ATPase-coupled guanine transmembrane transporter activity RHEA:20832|EC:7.6.2.6|MetaCyc:3.6.3.37-RXN molecular_function owl:Class
GO:1903716 biolink:NamedThing guanine transmembrane transport The process in which guanine is transported across a membrane. got7fsn_ti vw 2014-12-08T12:18:27Z biological_process owl:Class
GO:0048477 biolink:NamedThing oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster. got7fsn_ti ovum development GO:0048157|GO:0009993 Wikipedia:Oogenesis biological_process owl:Class
GO:0039625 biolink:NamedThing viral inner capsid The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions. got7fsn_ti inner capsid bf 2012-07-18T04:05:35Z cellular_component owl:Class
GO:0048587 biolink:NamedThing regulation of short-day photoperiodism, flowering Any process that modulates the frequency, rate or extent of short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. got7fsn_ti biological_process owl:Class
GO:0036014 biolink:NamedThing cyanelle intermembrane space The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer. got7fsn_ti cyanelle envelope lumen|cyanelle periplasm bf 2011-10-10T02:12:28Z cellular_component owl:Class
GO:0033112 biolink:NamedThing cyanelle envelope The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space. got7fsn_ti cellular_component owl:Class
GO:1990270 biolink:NamedThing platelet-derived growth factor receptor-ligand complex A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes. got7fsn_ti PDGF-DD-receptor alpha-beta complex|PDGF receptor-ligand complex|PDGF-CC-receptor alpha complex|PDGF-DD-receptor beta complex|PDGF-CC-receptor alpha-beta complex|receptor-ligand complex|PDGF-BB-receptor beta complex|PDGF-BB-receptor alpha-beta complex|PDGF-AB-receptor beta complex|PDGF-CC-receptor beta complex|PDGF-AA-receptor alpha complex|PDGF-BB-receptor alpha complex|PDGF complex|PDGF-AB-receptor alpha complex An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay). bhm 2014-01-14T11:12:22Z cellular_component owl:Class
GO:0061497 biolink:NamedThing inner plaque of mitotic spindle pole body One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus. got7fsn_ti dph 2012-12-11T09:15:12Z cellular_component owl:Class
GO:0044732 biolink:NamedThing mitotic spindle pole body The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome. got7fsn_ti jl 2012-11-06T15:44:02Z cellular_component owl:Class
GO:0010849 biolink:NamedThing regulation of proton-transporting ATPase activity, rotational mechanism Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. got7fsn_ti regulation of hydrogen ion transporting ATPase activity, rotational mechanism|regulation of V-type ATPase activity biological_process owl:Class
GO:1902600 biolink:NamedThing proton transmembrane transport The directed movement of a proton across a membrane. got7fsn_ti hydrogen transmembrane transport|hydrogen ion transmembrane transport|proton transport|proton transmembrane transport|hydrogen transport|passive proton transport, down the electrochemical gradient|ATP hydrolysis coupled proton transport|hydrogen ion transport pr 2013-12-20T11:08:37Z GO:0006818|GO:0015992|GO:0015991 biological_process owl:Class
GO:0072057 biolink:NamedThing inner stripe development The process whose specific outcome is the progression of the inner stripe over time, from its formation to the mature structure. The inner stripe is a deep, centrally located portion of the renal outer medulla and is traversed by thin descending and thick ascending portions of the loops of Henle. got7fsn_ti mah 2010-01-25T04:01:58Z biological_process owl:Class
GO:0072054 biolink:NamedThing renal outer medulla development The process whose specific outcome is the progression of the renal outer medulla over time, from its formation to the mature structure. The renal outer medulla is the region of the kidney that lies between the renal cortex and the renal inner medulla. got7fsn_ti outer renal medulla development mah 2010-01-25T04:00:42Z biological_process owl:Class
GO:2000228 biolink:NamedThing positive regulation of pancreatic A cell differentiation Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation. got7fsn_ti positive regulation of pancreatic alpha cell differentiation mah 2010-11-09T03:43:42Z biological_process owl:Class
GO:0005929 biolink:NamedThing cilium A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. got7fsn_ti primary cilium|microtubule-based flagellum|flagellum|eukaryotic flagellum Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. GO:0072372 Wikipedia:Cilium|NIF_Subcellular:sao787716553|FMA:67181 cellular_component owl:Class
GO:0030990 biolink:NamedThing intraciliary transport particle A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules. got7fsn_ti intraflagellar transport particle|intraflagellar transport complex|IFT complex Note that we deem cilia and microtubule-based flagella to be equivalent. cellular_component owl:Class
GO:0060648 biolink:NamedThing mammary gland bud morphogenesis The process in which anatomical structures of the mammary gland buds are generated and organized. Mammary gland buds form by an outpocketing of the mammary placodes and grow to invade the mammary fat, when they form the mammary cord. got7fsn_ti dph 2009-05-29T08:42:22Z biological_process owl:Class
GO:1990562 biolink:NamedThing syndecan-syntenin-ALIX complex An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery. got7fsn_ti exosome complex An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction). bhm 2014-11-25T16:30:47Z cellular_component owl:Class
GO:0071971 biolink:NamedThing extracellular exosome assembly The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm. got7fsn_ti extracellular vesicular exosome assembly mah 2010-10-18T03:44:18Z biological_process owl:Class
GO:0044022 biolink:NamedThing histone kinase activity (H3-S28 specific) Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3. got7fsn_ti histone serine kinase activity (H3-S28 specific)|histone-serine kinase activity (H3-S28 specific) molecular_function owl:Class
GO:0043988 biolink:NamedThing histone H3-S28 phosphorylation The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone. got7fsn_ti histone H3 phosphorylation at S28|histone H3S28 phosphorylation biological_process owl:Class
GO:0000908 biolink:NamedThing taurine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite. got7fsn_ti alpha-ketoglutarate-dependent taurine dioxygenase activity|taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)|2-aminoethanesulfonate dioxygenase activity MetaCyc:RXN0-299|RHEA:15909|EC:1.14.11.17|KEGG_REACTION:R05320 molecular_function owl:Class
GO:0043676 biolink:NamedThing tectum The layer of sexine which forms a roof over the columella, granules or other infratectal elements. got7fsn_ti sexine 2 cellular_component owl:Class
GO:0106002 biolink:NamedThing mCRD-mediated mRNA stability complex A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP. got7fsn_ti mCRD-poly(A)-bridging complex|major coding region determinant of instability-mediated mRNA stability complex|major coding region instability determinant-mediated mRNA stability complex|major coding-region determinant of instability - poly(A) tail-bridging complex|major coding region instability determinant-poly(A)-bridging complex This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA. cellular_component owl:Class
GO:1900152 biolink:NamedThing negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. got7fsn_ti inhibition of deadenylation-dependent mRNA decay|down regulation of mRNA degradation, deadenylation-dependent decay|inhibition of mRNA catabolism, deadenylation-dependent|down regulation of mRNA catabolic process, deadenylylation-dependent|down regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of mRNA catabolism, deadenylation-dependent|inhibition of mRNA catabolic process, deadenylylation-dependent|down-regulation of mRNA breakdown, deadenylation-dependent decay|downregulation of mRNA catabolic process, deadenylation-dependent|negative regulation of mRNA breakdown, deadenylation-dependent decay|negative regulation of mRNA catabolic process, deadenylation-dependent|down-regulation of mRNA catabolism, deadenylation-dependent|inhibition of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|down regulation of mRNA catabolic process, deadenylation-dependent|inhibition of mRNA degradation, deadenylation-dependent decay|down-regulation of mRNA catabolism, deadenylylation-dependent|downregulation of deadenylation-dependent mRNA decay|negative regulation of mRNA catabolic process, deadenylylation-dependent|inhibition of mRNA breakdown, deadenylation-dependent decay|negative regulation of deadenylation-dependent mRNA decay|downregulation of mRNA breakdown, deadenylation-dependent decay|downregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|down-regulation of deadenylation-dependent mRNA decay|down regulation of mRNA breakdown, deadenylation-dependent decay|inhibition of nuclear mRNA catabolic process, deadenylation-dependent decay|negative regulation of mRNA degradation, deadenylation-dependent decay|down regulation of mRNA catabolism, deadenylation-dependent|downregulation of mRNA degradation, deadenylation-dependent decay|downregulation of nuclear mRNA catabolic process, deadenylation-dependent decay|downregulation of mRNA catabolic process, deadenylylation-dependent|down-regulation of nuclear mRNA catabolic process, deadenylation-dependent decay|negative regulation of nuclear mRNA catabolic process, deadenylation-dependent decay|down-regulation of mRNA catabolic process, deadenylylation-dependent|down-regulation of mRNA degradation, deadenylation-dependent decay|inhibition of mRNA catabolism, deadenylylation-dependent|inhibition of mRNA catabolic process, deadenylation-dependent|negative regulation of mRNA catabolism, deadenylylation-dependent|down regulation of deadenylation-dependent mRNA decay|down-regulation of mRNA catabolic process, deadenylation-dependent|down regulation of mRNA catabolism, deadenylylation-dependent|down-regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|downregulation of mRNA catabolism, deadenylation-dependent|downregulation of mRNA catabolism, deadenylylation-dependent|down regulation of nuclear mRNA catabolic process, deadenylation-dependent decay bf 2012-03-07T09:14:49Z biological_process owl:Class
GO:0046976 biolink:NamedThing histone methyltransferase activity (H3-K27 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group onto lysine at position 27 of the histone H3 protein. got7fsn_ti histone lysine N-methyltransferase activity (H3-K27 specific)|histone methylase activity (H3-K27 specific) Reactome:R-HSA-3240295 molecular_function owl:Class
GO:0070734 biolink:NamedThing histone H3-K27 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 27 of the histone. got7fsn_ti histone H3K27me|histone lysine H3 K27 methylation|histone H3 K27 methylation mah 2009-06-19T11:44:37Z biological_process owl:Class
GO:0009865 biolink:NamedThing pollen tube adhesion The process in which the pollen tube adheres to cells of the stigma and style. got7fsn_ti biological_process owl:Class
GO:0090692 biolink:NamedThing mitochondrial membrane scission site The site on the mitochondrial membrane where the separation of a single continuous mitochondrial membrane into two membranes occurs as a final step in mitochondrial fission. got7fsn_ti tb 2016-08-24T10:46:09Z cellular_component owl:Class
GO:1990918 biolink:NamedThing double-strand break repair involved in meiotic recombination The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination. got7fsn_ti al 2015-12-11T01:01:14Z biological_process owl:Class
GO:0042166 biolink:NamedThing acetylcholine binding Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. got7fsn_ti molecular_function owl:Class
GO:0002430 biolink:NamedThing complement receptor mediated signaling pathway A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway. got7fsn_ti immune response-regulating cell surface receptor signalling pathway|complement receptor mediated signalling pathway biological_process owl:Class
GO:0061739 biolink:NamedThing protein lipidation involved in autophagosome assembly The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly. got7fsn_ti dph 2015-10-14T12:02:01Z biological_process owl:Class
GO:0043669 biolink:NamedThing ectexine The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections. got7fsn_ti Note that ectexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'endexine ; GO:0043671'. cellular_component owl:Class
GO:1990722 biolink:NamedThing DAPK1-calmodulin complex A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding. got7fsn_ti death-associated protein kinase 1 - calmodulin complex bhm 2015-04-01T13:05:17Z cellular_component owl:Class
GO:0043065 biolink:NamedThing positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. got7fsn_ti pro-apoptosis|up regulation of apoptosis|positive regulation of apoptosis|activation of apoptosis|upregulation of apoptosis|stimulation of apoptosis|up-regulation of apoptosis This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is positively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. biological_process owl:Class
GO:0044250 biolink:NamedThing negative regulation of metabolic activity involved in hibernation The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation. got7fsn_ti down regulation of metabolic activity during hibernation|down-regulation of metabolic activity during hibernation|downregulation of metabolic activity during hibernation|inhibition of metabolic activity during hibernation|negative regulation of metabolic activity during hibernation biological_process owl:Class
GO:0042750 biolink:NamedThing hibernation Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs. got7fsn_ti Wikipedia:Hibernation biological_process owl:Class
GO:0070057 biolink:NamedThing prospore membrane spindle pole body attachment site The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus. got7fsn_ti forespore membrane spindle pole body attachment site|prospore membrane SPB attachment site|forespore membrane SPB attachment site cellular_component owl:Class
GO:0072656 biolink:NamedThing maintenance of protein location in mitochondrion Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere. got7fsn_ti mah 2011-02-14T02:30:43Z biological_process owl:Class
GO:0097563 biolink:NamedThing left middle basal body pair Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally. got7fsn_ti Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T16:11:14Z cellular_component owl:Class
NCBITaxon:5738 biolink:NamedThing got7fsn_ti owl:Class
GO:0031587 biolink:NamedThing positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. got7fsn_ti positive regulation of IP3 receptor activity|positive regulation of inositol-1,4,5-trisphosphate receptor activity|up-regulation of IP3 receptor activity|upregulation of IP3 receptor activity|stimulation of IP3 receptor activity|up regulation of IP3 receptor activity|activation of IP3 receptor activity biological_process owl:Class
GO:0051209 biolink:NamedThing release of sequestered calcium ion into cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment. got7fsn_ti cytosolic release of sequestered calcium ion (Ca2+)|release of sequestered calcium ion (Ca2+)|release of sequestered calcium ion into cytoplasm|release of stored calcium ion (Ca2+) into cytoplasm|release of stored calcium ion (Ca2+)|calcium ion (Ca2+) mobilization|calcium mobilization|cytosolic release of stored calcium ion (Ca2+)|cytoplasmic release of stored calcium ion (Ca2+)|cytoplasmic release of sequestered calcium ion (Ca2+)|release of stored calcium ion (Ca2+) into cytosol biological_process owl:Class
GO:0036342 biolink:NamedThing post-anal tail morphogenesis The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance. got7fsn_ti bf 2012-09-11T13:54:49Z biological_process owl:Class
NCBITaxon:7711 biolink:NamedThing got7fsn_ti owl:Class
GO:0048194 biolink:NamedThing Golgi vesicle budding The evagination of the Golgi membrane, resulting in formation of a vesicle. got7fsn_ti Golgi-derived vesicle budding|dictyosome vesicle budding biological_process owl:Class
GO:0002405 biolink:NamedThing antigen sampling by dendritic cells in mucosal-associated lymphoid tissue The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue. got7fsn_ti antigen sampling by dendritic cells in MALT biological_process owl:Class
GO:0060657 biolink:NamedThing regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signaling Any process that modulates the rate, frequency, or extent of mammary gland cord elongation as a result of a signal being created by a mesenchymal cell that is a precursor to the mammary fat and its subsequent reception and interpretation by an mammary cord epithelial cell. got7fsn_ti regulation of mammary gland cord elongation by mammary fat precursor cell-epithelial cell signalling dph 2009-05-29T09:43:08Z biological_process owl:Class
GO:0010278 biolink:NamedThing chloroplast outer membrane translocon The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner. got7fsn_ti cellular_component owl:Class
GO:1901394 biolink:NamedThing positive regulation of transforming growth factor beta1 activation Any process that activates or increases the frequency, rate or extent of transforming growth factor beta1 activation. got7fsn_ti up regulation of L-TGF-beta 1 activation|up-regulation of latent-TGF-beta1 activation|activation of L-TGF-beta 1 activation|up-regulation of TGFB1 activation|upregulation of TGFbeta 1 activation|upregulation of transforming growth factor-beta1 activation|positive regulation of L-TGF-beta 1 activation|upregulation of L-TGF-beta 1 activation|positive regulation of transforming growth factor-beta1 activation|up regulation of TGF-beta 1 activation|activation of transforming growth factor beta1 activation|upregulation of TGF-beta 1 activation|activation of transforming growth factor-beta1 activation|up regulation of transforming growth factor-beta1 activation|up regulation of TGFbeta 1 activation|activation of TGFB1 activation|positive regulation of latent-TGF-beta1 activation|activation of latent-TGF-beta1 activation|positive regulation of TGFB1 activation|up-regulation of L-TGF-beta 1 activation|up-regulation of TGFbeta 1 activation|up-regulation of transforming growth factor-beta1 activation|up-regulation of transforming growth factor beta1 activation|upregulation of latent-TGF-beta1 activation|upregulation of TGFB1 activation|positive regulation of TGF-beta 1 activation|positive regulation of TGFbeta 1 activation|up-regulation of TGF-beta 1 activation|up regulation of transforming growth factor beta1 activation|upregulation of transforming growth factor beta1 activation|activation of TGFbeta 1 activation|activation of TGF-beta 1 activation|up regulation of TGFB1 activation|up regulation of latent-TGF-beta1 activation bf 2012-10-01T10:41:33Z biological_process owl:Class
GO:0032905 biolink:NamedThing transforming growth factor beta1 production The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti TGF-B1 production|transforming growth factor-beta1 production|TGFB1 production biological_process owl:Class
GO:0001946 biolink:NamedThing lymphangiogenesis Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels. got7fsn_ti lymph vessel formation Wikipedia:Lymphangiogenesis biological_process owl:Class
GO:0036303 biolink:NamedThing lymph vessel morphogenesis The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph. got7fsn_ti bf 2012-08-08T10:08:47Z biological_process owl:Class
GO:0090267 biolink:NamedThing positive regulation of mitotic cell cycle spindle assembly checkpoint Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. got7fsn_ti tb 2010-02-05T02:09:44Z biological_process owl:Class
GO:0006038 biolink:NamedThing cell wall chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. got7fsn_ti cell wall chitin synthesis|cell wall chitin biosynthesis|cell wall chitin anabolism|cell wall chitin formation biological_process owl:Class
NCBITaxon:89593 biolink:NamedThing got7fsn_ti owl:Class
GO:0034720 biolink:NamedThing histone H3-K4 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone. got7fsn_ti H3K4 demethylation (me1 me2 and me3) biological_process owl:Class
GO:0044471 biolink:NamedThing envenomation resulting in pore formation in membrane of other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism. got7fsn_ti jl 2012-01-19T01:39:47Z biological_process owl:Class
GO:0097649 biolink:NamedThing A axonemal microtubule A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule. got7fsn_ti A tubule pr 2014-09-10T20:41:28Z cellular_component owl:Class
GO:0010956 biolink:NamedThing negative regulation of calcidiol 1-monooxygenase activity Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O. got7fsn_ti tb 2009-05-06T11:21:34Z biological_process owl:Class
GO:0042368 biolink:NamedThing vitamin D biosynthetic process The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). got7fsn_ti ergocalciferol biosynthetic process|vitamin D synthesis|calciferol biosynthesis|vitamin D biosynthesis|vitamin D anabolism|calciferol biosynthetic process|cholecalciferol biosynthetic process|cholecalciferol biosynthesis|vitamin D formation|ergocalciferol biosynthesis biological_process owl:Class
GO:0000241 biolink:NamedThing diakinesis The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Meiosis#Diakinesis|Wikipedia:Diakinesis biological_process owl:Class
GO:0060040 biolink:NamedThing retinal bipolar neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a bipolar cell, the last neuron to be generated in the retina. got7fsn_ti biological_process owl:Class
GO:0003407 biolink:NamedThing neural retina development The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. got7fsn_ti dph 2009-12-21T02:15:14Z biological_process owl:Class
GO:0030479 biolink:NamedThing actin cortical patch An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. got7fsn_ti actin patch GO:0005857 cellular_component owl:Class
GO:0000240 biolink:NamedThing diplotene The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Meiosis#Diplotene|Wikipedia:Diplotene biological_process owl:Class
GO:0000328 biolink:NamedThing fungal-type vacuole lumen The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae. got7fsn_ti lumen of vacuole with cell cycle-correlated morphology cellular_component owl:Class
GO:0090656 biolink:NamedThing t-circle formation A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD). got7fsn_ti telomeric circle formation tb 2015-07-02T11:44:23Z biological_process owl:Class
GO:0034974 biolink:NamedThing Swi5-Swi2 complex A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching. got7fsn_ti Swi5 complex Note that this term refers to Schizosaccharomyces pombe Swi5 and Swi2, which should not be confused with the unrelated Saccharomyces Swi5p and Swi2p. cellular_component owl:Class
GO:0002576 biolink:NamedThing platelet degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. got7fsn_ti platelet exocytosis biological_process owl:Class
GO:0032324 biolink:NamedThing molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. got7fsn_ti molybdopterin cofactor biosynthesis|molybdopterin cofactor synthesis|molybdopterin cofactor formation|molybdopterin cofactor anabolism MetaCyc:Molybdenum-Cofactor-Biosynthesis biological_process owl:Class
GO:0030366 biolink:NamedThing molybdopterin synthase activity Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis. got7fsn_ti EC:2.8.1.12|Reactome:R-HSA-947541|RHEA:26333 molecular_function owl:Class
GO:0010431 biolink:NamedThing seed maturation A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination. got7fsn_ti biological_process owl:Class
GO:0014021 biolink:NamedThing secondary neural tube formation The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals. got7fsn_ti medullary cord biosynthesis|neural rod formation|medullary cord formation|secondary neurulation GO:0014026 biological_process owl:Class
NCBITaxon:40674 biolink:NamedThing got7fsn_ti owl:Class
GO:0002822 biolink:NamedThing regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. got7fsn_ti biological_process owl:Class
NCBITaxon:7776 biolink:NamedThing got7fsn_ti owl:Class
GO:0060318 biolink:NamedThing definitive erythrocyte differentiation Erythrocyte differentiation which occurs as part of the process of definitive hemopoiesis. got7fsn_ti definitive RBC differentiation|definitive erythropoiesis|definitive red blood cell differentiation biological_process owl:Class
GO:0035564 biolink:NamedThing regulation of kidney size Any process that modulates the size of a kidney. got7fsn_ti bf 2010-07-23T11:28:22Z biological_process owl:Class
GO:0010718 biolink:NamedThing positive regulation of epithelial to mesenchymal transition Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. got7fsn_ti biological_process owl:Class
GO:0090726 biolink:NamedThing cortical dynamic polarity patch A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation. got7fsn_ti dynamic polarity patch at the cell cortex tb 2016-11-22T16:17:02Z cellular_component owl:Class
GO:0005938 biolink:NamedThing cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. got7fsn_ti peripheral cytoplasm|cell periphery Wikipedia:Cell_cortex cellular_component owl:Class
GO:0043952 biolink:NamedThing protein transport by the Sec complex The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide. got7fsn_ti protein secretion by the Sec complex|protein translocation by the Sec complex Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular structure term 'cell envelope Sec protein transport complex ; GO:0031522'. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'protein secretion by the type II secretion system ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'SRP-dependent cotranslational protein targeting to membrane, translocation ; GO:0006616'. Note that this term is used for annotation of proteins that compose the transport complex but not the proteins being transported. biological_process owl:Class
GO:0034739 biolink:NamedThing histone deacetylase activity (H4-K16 specific) Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. got7fsn_ti molecular_function owl:Class
GO:1990178 biolink:NamedThing HU-DNA complex A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure. got7fsn_ti HU complex bhm 2013-08-30T13:06:53Z cellular_component owl:Class
GO:0043590 biolink:NamedThing bacterial nucleoid The region of a bacterial cell to which the DNA is confined. got7fsn_ti cellular_component owl:Class
GO:0001746 biolink:NamedThing Bolwig's organ morphogenesis The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain. got7fsn_ti biological_process owl:Class
GO:0055034 biolink:NamedThing Bolwig's organ development The process whose specific outcome is the progression of the Bolwig's organ over time, from its formation to the mature structure. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain. got7fsn_ti biological_process owl:Class
GO:0043055 biolink:NamedThing maintenance of dauer Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development. got7fsn_ti maintenance of dormancy in the nematode biological_process owl:Class
GO:0031299 biolink:NamedThing taurine-pyruvate aminotransferase activity Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde. got7fsn_ti Tpa|taurine:pyruvate aminotransferase activity EC:2.6.1.77|RHEA:10420|KEGG_REACTION:R05652|MetaCyc:TAURINE-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:0097554 biolink:NamedThing left anterior flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell. got7fsn_ti left anterior cilium Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T12:47:41Z cellular_component owl:Class
GO:0005751 biolink:NamedThing mitochondrial respiratory chain complex IV A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). got7fsn_ti GO:0005752 cellular_component owl:Class
GO:0005746 biolink:NamedThing mitochondrial respirasome The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. got7fsn_ti mitochondrial respirasome|mitochondrial electron transport chain|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain|mitochondrial respiratory supercomplex https://github.com/geneontology/go-ontology/issues/12846 pr 2012-02-23T05:13:54Z GO:0097249 cellular_component owl:Class
GO:0010007 biolink:NamedThing magnesium chelatase complex A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner. got7fsn_ti cellular_component owl:Class
GO:0015214 biolink:NamedThing pyrimidine nucleoside transmembrane transporter activity Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0072531 biolink:NamedThing pyrimidine-containing compound transmembrane transport The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. got7fsn_ti pyrimidine-containing compound membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2011-01-05T01:47:22Z biological_process owl:Class
GO:0061562 biolink:NamedThing cranial ganglion structural organization The process that contributes to creating the structural organization of a cranial ganglion. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti cranial ganglia structural organization dph 2013-07-10T09:10:52Z biological_process owl:Class
GO:0005353 biolink:NamedThing fructose transmembrane transporter activity Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. got7fsn_ti fructose permease activity|fructose porter activity GO:0019192|GO:0015585 Reactome:R-HSA-189222 molecular_function owl:Class
GO:0015755 biolink:NamedThing fructose transmembrane transport The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. got7fsn_ti fructose transport biological_process owl:Class
GO:1903024 biolink:NamedThing positive regulation of ascospore-type prospore membrane formation Any process that activates or increases the frequency, rate or extent of formation of an ascospore-type prospore membrane. got7fsn_ti upregulation of FSM assembly|activation of ascospore-type prospore membrane assembly|upregulation of FSM biosynthesis|up-regulation of forespore membrane biosynthesis|up-regulation of FSM assembly|upregulation of ascospore-type prospore membrane assembly|positive regulation of forespore membrane formation|activation of FSM formation|positive regulation of FSM biosynthesis|upregulation of FSM formation|up-regulation of forespore membrane formation|activation of forespore membrane formation|activation of forespore membrane biosynthesis|up regulation of forespore membrane biosynthesis|positive regulation of FSM assembly|upregulation of forespore membrane biosynthesis|up regulation of forespore membrane formation|up regulation of FSM biosynthesis|positive regulation of ascospore-type prospore membrane assembly|up regulation of ascospore-type prospore membrane assembly|up regulation of FSM formation|positive regulation of FSM formation|upregulation of forespore membrane formation|up-regulation of ascospore-type prospore membrane assembly|activation of FSM biosynthesis|up-regulation of FSM formation|up-regulation of FSM biosynthesis|positive regulation of forespore membrane biosynthesis|up regulation of FSM assembly|activation of FSM assembly al 2014-05-15T08:51:58Z biological_process owl:Class
GO:0097342 biolink:NamedThing ripoptosome A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. got7fsn_ti necrosome|Tnfr1-CII|TNFR1 complex II It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330). pr 2012-06-18T12:55:34Z cellular_component owl:Class
GO:0005829 biolink:NamedThing cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. got7fsn_ti NIF_Subcellular:sao101633890|Wikipedia:Cytosol cellular_component owl:Class
GO:1990685 biolink:NamedThing HDL-containing protein-lipid-RNA complex A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other. got7fsn_ti Examples of HDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoproteins (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034364 'high-density lipoprotein particle', which describes complexes of proteins and lipids only, without RNAs. pr 2015-03-11T14:56:52Z cellular_component owl:Class
CHEBI:39025 biolink:NamedThing got7fsn_ti owl:Class
GO:0048620 biolink:NamedThing post-embryonic hindgut morphogenesis The process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase. got7fsn_ti biological_process owl:Class
GO:0007442 biolink:NamedThing hindgut morphogenesis The process in which the anatomical structures of the hindgut are generated and organized. got7fsn_ti biological_process owl:Class
GO:2000431 biolink:NamedThing regulation of cytokinesis, actomyosin contractile ring assembly Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. got7fsn_ti regulation of contractile ring assembly vw 2011-03-03T12:17:41Z biological_process owl:Class
GO:0061380 biolink:NamedThing superior colliculus development The process whose specific outcome is the progression of the superior colliculus over time, from its formation to the mature structure. The superior colliculus is also known as the optic tectum or simply tectum and is a paired structure that forms a major component of the vertebrate midbrain. got7fsn_ti dph 2010-11-09T09:51:00Z biological_process owl:Class
GO:0061378 biolink:NamedThing corpora quadrigemina development The progression of the corpora quadrigemina over time, from its formation to the mature structure. The corpora quadrigemina is a part of the midbrain that is made up of the superior and inferior colliculi. got7fsn_ti dph 2010-11-09T09:45:36Z biological_process owl:Class
GO:0002908 biolink:NamedThing regulation of peripheral B cell deletion Any process that modulates the frequency, rate, or extent of peripheral B cell deletion. got7fsn_ti biological_process owl:Class
GO:0031091 biolink:NamedThing platelet alpha granule A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). got7fsn_ti platelet alpha-granule Wikipedia:Platelet_alpha-granule cellular_component owl:Class
CL:0000233 biolink:NamedThing got7fsn_ti owl:Class
GO:0033282 biolink:NamedThing protein C inhibitor-acrosin complex A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin. got7fsn_ti PCI-ACR complex|SERPINA5-acrosin complex|plasma serine protease inhibitor-acrosin complex|serpin A5-acrosin complex|PCI-acrosin complex cellular_component owl:Class
GO:0061277 biolink:NamedThing mesonephric nephron tubule formation The developmental process pertaining to the initial formation of a mesonephric nephron tubule from unspecified parts. A mesonephric nephron tubule is an epithelial tube that is part of a nephron in the mesonephros. got7fsn_ti dph 2010-09-02T01:16:21Z biological_process owl:Class
GO:0070916 biolink:NamedThing inositol phosphoceramide synthase complex A protein complex that possesses inositol phosphoceramide synthase activity and contains a catalytic subunit and a regulatory subunit (Aur1p and Kei1p, respectively, in Saccharomyces). got7fsn_ti IPC synthase complex mah 2009-09-10T05:23:21Z cellular_component owl:Class
GO:0042734 biolink:NamedThing presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. got7fsn_ti pre-synaptic membrane|presynaptic plasma membrane cellular_component owl:Class
GO:0042302 biolink:NamedThing structural constituent of cuticle The action of a molecule that contributes to the structural integrity of a cuticle. got7fsn_ti molecular_function owl:Class
GO:0140479 biolink:NamedThing ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide. got7fsn_ti pg 2020-06-25T09:58:21Z biological_process owl:Class
GO:0021814 biolink:NamedThing cell motility involved in cerebral cortex radial glia guided migration The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration. got7fsn_ti cell locomotion involved in cerebral cortex glial-mediated radial migration|cell locomotion involved in cerebral cortex radial glia guided migration biological_process owl:Class
GO:0015225 biolink:NamedThing biotin transmembrane transporter activity Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. got7fsn_ti biotin transporter activity|vitamin H transporter activity|vitamin B7 transporter activity al 2012-11-08T14:18:56Z GO:1901603 RHEA:28458 molecular_function owl:Class
GO:0015878 biolink:NamedThing biotin transport The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. got7fsn_ti vitamin H transport|vitamin B7 transport biological_process owl:Class
GO:0110069 biolink:NamedThing syncytial embryo cellularization The separation of a syncytial embryo into individual cells. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14543 kmv 2017-11-22T19:59:19Z biological_process owl:Class
GO:0030493 biolink:NamedThing bacteriochlorophyll metabolic process The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. got7fsn_ti bacteriochlorophyll metabolism biological_process owl:Class
GO:0003007 biolink:NamedThing heart morphogenesis The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. got7fsn_ti cardiac morphogenesis biological_process owl:Class
GO:0015093 biolink:NamedThing ferrous iron transmembrane transporter activity Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. got7fsn_ti ferrous iron uptake transmembrane transporter activity GO:0015639 Reactome:R-HSA-442368|Reactome:R-HSA-1362417|Reactome:R-HSA-5655760|RHEA:28486 molecular_function owl:Class
GO:0034755 biolink:NamedThing iron ion transmembrane transport A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti iron ion membrane transport|low-affinity iron ion transmembrane transport|high affinity ferrous ion transmembrane transport|transmembrane iron transport|high-affinity iron ion transport|high-affinity iron ion transmembrane transport|iron(2+) transmembrane transport|low affinity iron ion transport|high affinity iron ion transport|low-affinity iron ion transport|ferrous ion transmembrane transport|high-affinity ferrous ion transmembrane transport|ferrous iron transmembrane transport Note that this term is not intended for use in annotating lateral movement within membranes. vw 2015-02-06T11:29:22Z GO:1903874|GO:0000040|GO:0006827|GO:0061839 biological_process owl:Class
GO:0016935 biolink:NamedThing glycine-gated chloride channel complex A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts. got7fsn_ti cellular_component owl:Class
GO:0002195 biolink:NamedThing 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs. got7fsn_ti In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli. hjd 2011-08-31T02:20:06Z biological_process owl:Class
GO:0043533 biolink:NamedThing inositol 1,3,4,5 tetrakisphosphate binding Binding to inositol 1,3,4,5 tetrakisphosphate. got7fsn_ti InsP4 binding|IP4 binding molecular_function owl:Class
GO:0050833 biolink:NamedThing pyruvate transmembrane transporter activity Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other. got7fsn_ti monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity Reactome:R-HSA-372342 molecular_function owl:Class
GO:0010312 biolink:NamedThing detoxification of zinc ion Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion. got7fsn_ti biological_process owl:Class
GO:0000095 biolink:NamedThing S-adenosyl-L-methionine transmembrane transporter activity Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. got7fsn_ti S-adenosyl methionine transporter activity|S-adenosylmethionine transmembrane transporter activity|S-adenosylmethionine permease activity|S-adenosyl methionine permease activity|S-adenosylmethionine transporter activity|SAM transmembrane transporter activity GO:0015177 Reactome:R-HSA-8855062 molecular_function owl:Class
GO:1901962 biolink:NamedThing S-adenosyl-L-methionine transmembrane transport The directed movement of S-adenosyl-L-methionine across a membrane. got7fsn_ti S-adenosylmethionine transmembrane transport|SAM transmembrane transport jl 2013-02-20T14:45:08Z biological_process owl:Class
GO:0061215 biolink:NamedThing mesonephric nephron development The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. A nephron is the functional unit of the kidney. got7fsn_ti dph 2010-08-17T03:31:08Z biological_process owl:Class
GO:0120078 biolink:NamedThing cell adhesion involved in sprouting angiogenesis The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the formation of a blood vessel network. got7fsn_ti cell adhesion involved in blood vessel anastomosis|cell adhesion involved in vascular anastomosis https://github.com/geneontology/go-ontology/issues/13690 krc 2017-06-27T21:29:47Z biological_process owl:Class
GO:0072660 biolink:NamedThing maintenance of protein location in plasma membrane Any process in which a protein is maintained in a specific location in the plasma membrane, and is prevented from moving elsewhere. got7fsn_ti mah 2011-02-14T02:46:08Z biological_process owl:Class
GO:0072659 biolink:NamedThing protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. got7fsn_ti protein-plasma membrane targeting|protein localisation in plasma membrane|protein targeting to plasma membrane|protein localization in plasma membrane tb 2009-07-10T10:29:23Z GO:0090002|GO:0072661 biological_process owl:Class
GO:1903583 biolink:NamedThing positive regulation of basophil degranulation Any process that activates or increases the frequency, rate or extent of basophil degranulation. got7fsn_ti upregulation of basophil degranulation|activation of basophil degranulation|up-regulation of basophil degranulation|up regulation of basophil degranulation sl 2014-10-31T17:37:42Z biological_process owl:Class
GO:0140091 biolink:NamedThing mBAF complex A muscle cell-specific SWI/SNF-type complex that contains eight to fourteen proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes, and the muscle-specific product of the DPF3/BAF45C gene or an ortholog thereof. got7fsn_ti muscle-specific BAF complex|muscle-type SWI/SNF complex|muscle-specific SWI/SNF complex|muscle-type BAF complex pg 2017-09-05T09:20:45Z cellular_component owl:Class
GO:0098666 biolink:NamedThing G protein-coupled serotonin receptor complex A protein complex that is capable of G protein-coupled serotonin receptor activity. got7fsn_ti G-protein coupled serotonin receptor complex https://github.com/geneontology/go-ontology/issues/12942 dos 2016-12-21T12:28:12Z cellular_component owl:Class
GO:0098664 biolink:NamedThing G protein-coupled serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands. got7fsn_ti G-protein coupled serotonin receptor signaling pathway dos 2016-12-21T12:07:58Z biological_process owl:Class
GO:0007464 biolink:NamedThing R3/R4 cell fate commitment The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres. got7fsn_ti biological_process owl:Class
GO:0042067 biolink:NamedThing establishment of ommatidial planar polarity The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part. got7fsn_ti establishment of ommatidial polarity biological_process owl:Class
GO:0072011 biolink:NamedThing glomerular endothelium development The process whose specific outcome is the progression of the glomerular endothelium over time, from its formation to the mature structure. The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus. got7fsn_ti mah 2010-01-25T02:02:57Z biological_process owl:Class
GO:0022005 biolink:NamedThing midbrain-hindbrain boundary maturation during neural plate development A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. got7fsn_ti midbrain-hindbrain boundary maturation involved in neural plate development biological_process owl:Class
GO:0021732 biolink:NamedThing midbrain-hindbrain boundary maturation A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. got7fsn_ti MHB maturation|isthmus maturation biological_process owl:Class
GO:0072273 biolink:NamedThing metanephric nephron morphogenesis The process in which the anatomical structures of the metanephric nephron are generated and organized. A metanephric nephron is the functional unit of the metanephros. got7fsn_ti mah 2010-03-30T03:33:19Z biological_process owl:Class
GO:0003338 biolink:NamedThing metanephros morphogenesis The process in which the anatomical structures of the metanephros are generated and organized. got7fsn_ti dph 2009-11-24T09:32:09Z biological_process owl:Class
GO:1990205 biolink:NamedThing taurine dioxygenase complex A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD. got7fsn_ti alpha-ketoglutarate-dependent taurine dioxygenase complex|2-aminoethanesulfonate dioxygenase complex|TauD complex bhm 2013-10-07T13:03:15Z cellular_component owl:Class
GO:0012507 biolink:NamedThing ER to Golgi transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. got7fsn_ti COPII coated vesicle membrane|endoplasmic reticulum-Golgi transport vesicle membrane|ER to Golgi constitutive secretory pathway transport vesicle membrane|ER-Golgi transport vesicle membrane|endoplasmic reticulum to Golgi transport vesicle membrane GO:0030664 cellular_component owl:Class
GO:0030134 biolink:NamedThing COPII-coated ER to Golgi transport vesicle A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport). got7fsn_ti ER-Golgi transport vesicle|COPII-coated vesicle|COPII-associated vesicle|endoplasmic reticulum to Golgi transport vesicle|ER to Golgi transport vesicle|COPII-associated ER to Golgi transport vesicle|ER to Golgi constitutive secretory pathway transport vesicle|endoplasmic reticulum-Golgi transport vesicle|COPII vesicle pg 2017-06-22T16:26:57Z GO:0030138|GO:0140045 cellular_component owl:Class
GO:0035052 biolink:NamedThing dorsal vessel aortic cell fate commitment The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0035054 biolink:NamedThing embryonic heart tube anterior/posterior pattern specification The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta. got7fsn_ti biological_process owl:Class
GO:2001192 biolink:NamedThing negative regulation of gamma-delta T cell activation involved in immune response Any process that stops, prevents or reduces the frequency, rate or extent of gamma-delta T cell activation involved in immune response. got7fsn_ti negative regulation of gamma-delta T cell activation during immune response|negative regulation of gamma-delta T-cell activation during immune response|negative regulation of gamma-delta T-lymphocyte activation during immune response|negative regulation of gamma-delta T lymphocyte activation during immune response yaf 2011-11-03T04:28:44Z biological_process owl:Class
GO:0150034 biolink:NamedThing distal axon That part of an axon close to and including the growth cone or the axon terminus. got7fsn_ti distal part of axon|distal part of the axon bc 2018-02-19T15:04:24Z cellular_component owl:Class
GO:0120310 biolink:NamedThing amastigogenesis The morphological, biochemical and genetic changes that induce the differentiation of metacyclic parasites into amastigotes in some of the Trypanosomatidae species such as Leishmania parasites and Trypanosoma cruzi. This process occurs inside the cells of the mammalian hosts, particularly in macrophages and other phagocytic cells for Leishmania parasites. got7fsn_ti krc 2021-03-23T21:17:19Z biological_process owl:Class
OBO:OPL_0000322 biolink:NamedThing got7fsn_ti owl:Class
GO:0075307 biolink:NamedThing positive regulation of conidium formation Any process that activates, maintains or increases the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. got7fsn_ti biological_process owl:Class
GO:0061890 biolink:NamedThing positive regulation of astrocyte activation Any process that increases the frequency, rate or extent of astrocyte activation. got7fsn_ti dph 2017-06-01T22:31:50Z biological_process owl:Class
GO:0048708 biolink:NamedThing astrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. got7fsn_ti biological_process owl:Class
GO:0009561 biolink:NamedThing megagametogenesis The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. got7fsn_ti embryo sac development from the megaspore|megagametophyte nucleus division Wikipedia:Megagametogenesis biological_process owl:Class
GO:1901016 biolink:NamedThing regulation of potassium ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity. got7fsn_ti regulation of potassium transporter activity rl 2012-06-15T01:13:49Z biological_process owl:Class
GO:0097381 biolink:NamedThing photoreceptor disc membrane Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane. got7fsn_ti pr 2012-10-05T11:01:22Z cellular_component owl:Class
GO:0001750 biolink:NamedThing photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. got7fsn_ti cellular_component owl:Class
GO:0098911 biolink:NamedThing regulation of ventricular cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti tb 2011-11-10T07:59:36Z biological_process owl:Class
GO:0034090 biolink:NamedThing maintenance of meiotic sister chromatid cohesion The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. got7fsn_ti biological_process owl:Class
GO:0060504 biolink:NamedThing positive regulation of epithelial cell proliferation involved in lung bud dilation Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung bud increasing in size radially. got7fsn_ti biological_process owl:Class
GO:0140223 biolink:NamedThing general transcription initiation factor activity A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. got7fsn_ti basal transcription factor activity|GTF activity|general transcription factor activity https://github.com/geneontology/go-ontology/issues/20253 Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation. pg 2018-05-24T07:51:23Z molecular_function owl:Class
GO:0140530 biolink:NamedThing MCM complex loading The protein localization process in which two MCM complexes become associated with chromatin at replication origins. MCM loading begins when origin-bound ORC and Cdc6 (Cdc18 in fission yeast) recruit one MCM2-7/Cdt1 complex to the origin, includes formation of a succession of intermediate complexes and ATP hydrolysis-dependent Mcm2-7 ring closure, and ends when two MCM hexamers fully encircle DNA, and are oriented head-to-head. The double hexamer is inactive for DNA unwinding. MCM loading takes place during G1 phase, and precedes CMG complex assembly. got7fsn_ti MCM complex loading at replication origin|MCM double hexamer formation at replication origin https://github.com/geneontology/go-ontology/issues/16570 pg 2020-10-12T16:46:23Z biological_process owl:Class
GO:1902315 biolink:NamedThing nuclear cell cycle DNA replication initiation Any DNA replication initiation that is involved in nuclear cell cycle DNA replication. got7fsn_ti DNA replication initiation involved in nuclear cell cycle DNA replication|DNA re-replication initiation involved in nuclear cell cycle DNA replication|DNA endoreduplication initiation involved in nuclear cell cycle DNA replication jl 2013-07-23T14:00:01Z biological_process owl:Class
GO:0097691 biolink:NamedThing bacterial extracellular vesicle Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells. got7fsn_ti pr 2015-09-24T11:31:44Z cellular_component owl:Class
GO:0021784 biolink:NamedThing postganglionic parasympathetic fiber development The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. got7fsn_ti biological_process owl:Class
GO:0048486 biolink:NamedThing parasympathetic nervous system development The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia. got7fsn_ti biological_process owl:Class
GO:0007433 biolink:NamedThing larval salivary gland boundary specification Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. got7fsn_ti larval salivary gland determination biological_process owl:Class
GO:0002168 biolink:NamedThing instar larval development The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0060347 biolink:NamedThing heart trabecula formation The process of creating a trabecula in the heart. A trabecula is a tissue element in the form of a small beam, strut or rod. got7fsn_ti heart trabecula biogenesis|cardiac trabecula formation|heart trabeculation|cardiac trabeculation biological_process owl:Class
GO:0021553 biolink:NamedThing olfactory nerve development The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. got7fsn_ti cranial nerve 1 development|CN 1 development|cranial nerve I development biological_process owl:Class
GO:2001310 biolink:NamedThing gliotoxin biosynthetic process The chemical reactions and pathways resulting in the formation of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. got7fsn_ti gliotoxin synthesis|gliotoxin anabolism|gliotoxin formation|gliotoxin biosynthesis pr 2012-03-15T03:42:18Z biological_process owl:Class
GO:1905607 biolink:NamedThing negative regulation of presynapse assembly Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly. got7fsn_ti negative regulation of presynapse biogenesis|down regulation of presynapse biogenesis|negative regulation of presynaptic terminal assembly|inhibition of presynaptic terminal assembly|down-regulation of presynaptic terminal assembly|down regulation of presynaptic terminal assembly|inhibition of presynapse biogenesis|downregulation of presynapse assembly|down-regulation of presynapse biogenesis|downregulation of presynaptic terminal assembly|down regulation of presynapse assembly|inhibition of presynapse assembly|down-regulation of presynapse assembly|downregulation of presynapse biogenesis bc 2016-10-27T16:08:20Z biological_process owl:Class
GO:0001712 biolink:NamedThing ectodermal cell fate commitment The cell differentiation process that results in commitment of a cell to become part of the ectoderm. got7fsn_ti ectoderm cell fate commitment biological_process owl:Class
GO:0007286 biolink:NamedThing spermatid development The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure. got7fsn_ti spermatid cell development|spermiogenesis Wikipedia:Spermiogenesis biological_process owl:Class
GO:1990354 biolink:NamedThing activated SUMO-E1 ligase complex A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins. got7fsn_ti SUMO-SAE1/2 complex An example of this is SAE1 in human (UniProt symbol Q9UBE0) in PMID:15660128 (inferred from direct assay). bhm 2014-03-31T13:22:45Z cellular_component owl:Class
GO:0031510 biolink:NamedThing SUMO activating enzyme complex A conserved heterodimeric complex with SUMO activating enzyme activity. got7fsn_ti SAE|SUMO E1 activator enzyme complex cellular_component owl:Class
GO:0030121 biolink:NamedThing AP-1 adaptor complex A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). got7fsn_ti HA1 clathrin adaptor|AP-1 related adapter complex|HA1 cellular_component owl:Class
GO:0035147 biolink:NamedThing branch fusion, open tracheal system Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint. got7fsn_ti tracheal branch fusion biological_process owl:Class
NCBITaxon:33317 biolink:NamedThing got7fsn_ti owl:Class
GO:0030913 biolink:NamedThing paranodal junction assembly Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier. got7fsn_ti paranodal junction biosynthesis|paranodal junction formation|paranodal axoglial junction formation biological_process owl:Class
GO:1905601 biolink:NamedThing negative regulation of receptor-mediated endocytosis involved in cholesterol transport Any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. got7fsn_ti down regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|down-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|negative regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|downregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|downregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|negative regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|down regulation of receptor-mediated endocytosis involved in cholesterol transport|down-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|inhibition of receptor-mediated endocytosis involved in cholesterol transport|down-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|downregulation of receptor-mediated endocytosis involved in cholesterol transport|inhibition of receptor-mediated endocytosis involved in intracellular cholesterol transport|negative regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|inhibition of receptor-mediated endocytosis of LDL|down regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|inhibition of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|negative regulation of receptor-mediated endocytosis of LDL|downregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|down-regulation of receptor-mediated endocytosis of LDL|down-regulation of receptor-mediated endocytosis involved in cholesterol transport|downregulation of receptor-mediated endocytosis of LDL|down regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|down regulation of receptor-mediated endocytosis of LDL|inhibition of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport pr 2016-10-26T13:01:52Z biological_process owl:Class
GO:0032367 biolink:NamedThing intracellular cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells. got7fsn_ti biological_process owl:Class
GO:0120308 biolink:NamedThing axonemal outer doublet assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal outer doublet, a part of an axoneme consisting of a doublet microtubule. got7fsn_ti axonemal outer doublet biogenesis|axonemal outer doublet formation|axonemal outer doublet morphogenesis|outer doublet assembly|axoneme outer doublet assembly|outer-doublet microtubule assembly https://github.com/geneontology/go-ontology/issues/21154 krc 2021-03-23T16:28:18Z biological_process owl:Class
GO:0021640 biolink:NamedThing trochlear nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. got7fsn_ti CN IV maturation biological_process owl:Class
GO:0021558 biolink:NamedThing trochlear nerve development The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. got7fsn_ti cranial nerve IV development|cranial nerve 4 development|CN IV development biological_process owl:Class
GO:0099079 biolink:NamedThing actin body An amorphous cytoskeletal structure consisting of aggregated actin filaments and associated proteins (including fibrin and capping protein) in which there is little or no actin filament turnover. In yeast (S. pombe and S. cerevisiae) these are found only in quiescent cells and are thought to serve as a reserve store of actin. got7fsn_ti cellular_component owl:Class
GO:1990462 biolink:NamedThing omegasome Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites. got7fsn_ti pr 2014-08-19T12:26:40Z cellular_component owl:Class
GO:0012505 biolink:NamedThing endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. got7fsn_ti Wikipedia:Endomembrane_system cellular_component owl:Class
GO:0086094 biolink:NamedThing positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction. got7fsn_ti adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction via ryanodine receptor phosphorylation bf biological_process owl:Class
GO:0003062 biolink:NamedThing regulation of heart rate by chemical signal The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine. got7fsn_ti chemical cardiac chronotropy|chemical signal regulation of heart contraction rate|chemical signal regulation of heart rate biological_process owl:Class
GO:0009655 biolink:NamedThing PSII associated light-harvesting complex II, core complex The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center. got7fsn_ti PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex|PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex|PSII associated light-harvesting complex II, core complex, LHCIId subcomplex cellular_component owl:Class
GO:0009517 biolink:NamedThing PSII associated light-harvesting complex II Protein-pigment complex associated with photosystem II. got7fsn_ti LHCII cellular_component owl:Class
GO:0048009 biolink:NamedThing insulin-like growth factor receptor signaling pathway The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands. got7fsn_ti IGF receptor signaling pathway|IGF receptor signalling pathway biological_process owl:Class
GO:0070937 biolink:NamedThing CRD-mediated mRNA stability complex A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9. got7fsn_ti coding-region determinant of instability-mediated mRNA stability complex|coding-region instability determinant -mediated mRNA stability complex See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. mah 2009-09-22T02:00:22Z cellular_component owl:Class
GO:0044499 biolink:NamedThing envenomation resulting in positive regulation of blood pressure in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism. got7fsn_ti jl 2012-02-01T02:39:06Z biological_process owl:Class
GO:0033617 biolink:NamedThing mitochondrial cytochrome c oxidase assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the mitochondrial inner membrane. got7fsn_ti mitochondrial respiratory chain complex IV assembly|mitochondrial cytochrome c oxidase complex assembly|mitochondrial cytochrome c oxidase biogenesis biological_process owl:Class
NCBITaxon:50557 biolink:NamedThing got7fsn_ti owl:Class
GO:0071053 biolink:NamedThing alpha9-beta1 integrin-ADAM2 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM2. got7fsn_ti ITGA9-ITGB1-ADAM2 complex mah 2009-11-03T03:58:22Z cellular_component owl:Class
GO:0048738 biolink:NamedThing cardiac muscle tissue development The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure. got7fsn_ti heart muscle development biological_process owl:Class
GO:0052928 biolink:NamedThing CTP:3'-cytidine-tRNA cytidylyltransferase activity Catalysis of the reaction: a tRNA with a 3' cytidine + CTP = a tRNA with a 3' CC end + diphosphate. got7fsn_ti EC:2.7.7.72|KEGG_REACTION:R09384 molecular_function owl:Class
GO:0010368 biolink:NamedThing chloroplast isoamylase complex A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized. got7fsn_ti cellular_component owl:Class
GO:1990851 biolink:NamedThing Wnt-Frizzled-LRP5/6 complex A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6. got7fsn_ti WNT-FZD-LRP5 complex|Wnt.Fz.LRP ternary complex|Fz/Wnt/LRP6 complex|Wnt receptor complex|Wnt-FZD-LRP5/6 trimeric complex|WNT-FZD-LRP6 complex|Frizzled-LRP5/6 complex|Wnt-induced Frizzled-LRP5/6 complex Given the number of Wnt proteins, Frizzled proteins and LRP proteins, many different trimeric complexes are likely to form. bf 2015-09-14T15:59:54Z cellular_component owl:Class
GO:0021745 biolink:NamedThing nucleus ambiguus development The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0021550 biolink:NamedThing medulla oblongata development The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. got7fsn_ti myelencephalon development|medulla development biological_process owl:Class
GO:0033353 biolink:NamedThing S-adenosylmethionine cycle A cyclic series of interconversions involving S-adenosylmethionine, S-adenosyl-L-homocysteine, L-cysteine, and L-methionine. Couples utilization of the methyl group of SAM with recycling of the homocysteinyl group and regeneration of methionine. got7fsn_ti SAM cycle|activated methyl cycle MetaCyc:PWY-5041 biological_process owl:Class
CHEBI:57844 biolink:NamedThing got7fsn_ti owl:Class
GO:0051300 biolink:NamedThing spindle pole body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome. got7fsn_ti spindle pole body maturation|SPB organization|spindle pole body organisation|spindle pole body organization and biogenesis|SPB maturation GO:0051426 biological_process owl:Class
GO:0020005 biolink:NamedThing symbiont-containing vacuole membrane The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont. got7fsn_ti parasitophorous vacuolar membrane cellular_component owl:Class
GO:0020003 biolink:NamedThing symbiont-containing vacuole Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont. got7fsn_ti Salmonella-containing vacuole|bacterium-containing vacuole|pathogen-occupied vacuole|parasitophorous vacuole|SCV Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope. cellular_component owl:Class
GO:0031164 biolink:NamedThing contractile vacuolar membrane The lipid bilayer surrounding the contractile vacuole. got7fsn_ti contractile vacuole membrane cellular_component owl:Class
GO:0048226 biolink:NamedThing Casparian strip Region of plant cell wall specialised to act as a seal to prevent back leakage of secreted material (analogous to tight junction between epithelial cells). Found particularly where root parenchymal cells secrete solutes into xylem vessels. The barrier is composed of suberin; a fatty substance, containing long chain fatty acids and fatty esters, also found in the cell walls of cork cells (phellem) in higher plants. got7fsn_ti Wikipedia:Casparian_strip cellular_component owl:Class
GO:0005615 biolink:NamedThing extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. got7fsn_ti intercellular space Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. NIF_Subcellular:sao1425028079 cellular_component owl:Class
GO:0044754 biolink:NamedThing autolysosome A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases. got7fsn_ti autophagolysosome|degrading autophagic vacuole|AVd jl 2012-11-27T15:42:12Z NIF_Subcellular:sao8444068431 cellular_component owl:Class
GO:0014900 biolink:NamedThing muscle hyperplasia A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ. got7fsn_ti biological_process owl:Class
UBERON:0002385 biolink:NamedThing got7fsn_ti owl:Class
GO:1990389 biolink:NamedThing CUE1-UBC7 ubiquitin-conjugating enzyme complex A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1. got7fsn_ti CUE1-UBC7 ubiquitin-conjugating enzyme (E2) An example of this is UBC7 in Saccharomyces cerevisiae (Q02159) in PMID:16179953 (inferred from direct assay). bhm 2014-06-02T15:35:58Z cellular_component owl:Class
GO:0042637 biolink:NamedThing catagen The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced. got7fsn_ti hair regression Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0048820 biolink:NamedThing hair follicle maturation A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state. got7fsn_ti biological_process owl:Class
GO:0032121 biolink:NamedThing meiotic attachment of telomeric heterochromatin to spindle pole body The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation. got7fsn_ti attachment of telomeric chromatin to spindle pole body|attachment of telomeres to spindle pole body biological_process owl:Class
GO:0045141 biolink:NamedThing meiotic telomere clustering The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis. got7fsn_ti bouquet biosynthesis|bouquet formation biological_process owl:Class
GO:0045186 biolink:NamedThing zonula adherens assembly Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. got7fsn_ti biological_process owl:Class
GO:0043297 biolink:NamedThing apical junction assembly The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents. got7fsn_ti apical junction complex assembly biological_process owl:Class
GO:0044200 biolink:NamedThing host cell nuclear membrane Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space. got7fsn_ti jl 2009-10-21T10:59:08Z cellular_component owl:Class
GO:0035209 biolink:NamedThing pupal development The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis. got7fsn_ti biological_process owl:Class
GO:0052887 biolink:NamedThing 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity Catalysis of the reaction: 7,9,9'-tri-cis-neurosporene + a quinone = 7,9,7',9'-tetra-cis-lycopene + a quinol. got7fsn_ti zeta-carotene desaturase activity|9,9'-di-cis-zeta-carotene desaturase activity|ZDS activity EC:1.3.5.6|MetaCyc:RXN-11357|KEGG_REACTION:R09658 molecular_function owl:Class
GO:2000632 biolink:NamedThing negative regulation of pre-miRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing. got7fsn_ti negative regulation of pre-microRNA processing dph 2011-04-18T03:50:19Z biological_process owl:Class
GO:0035196 biolink:NamedThing production of miRNAs involved in gene silencing by miRNA Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts. got7fsn_ti microRNA metabolic process|microRNA processing|microRNA metabolism|microRNA biosynthetic process|microRNA-mediated gene silencing, production of microRNAs|miRNA biogenesis|microRNA biogenesis|miRNA-mediated gene silencing, production of miRNAs|miRNA processing|gene silencing by miRNA, production of miRNAs|microRNA biosynthesis|production of microRNAs involved in gene silencing by microRNA GO:0030918 biological_process owl:Class
GO:0035242 biolink:NamedThing protein-arginine omega-N asymmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. got7fsn_ti S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming)|type I PRMT activity|type I protein arginine methyltransferase activity Note that type I protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N asymmetric methyltransferase activity ; GO:0035242'. RESID:AA0068|RESID:AA0069|RHEA:48096|EC:2.1.1.319 molecular_function owl:Class
GO:0019919 biolink:NamedThing peptidyl-arginine methylation, to asymmetrical-dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine. got7fsn_ti peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine RESID:AA0069|RESID:AA0068 biological_process owl:Class
GO:0005917 biolink:NamedThing nephrocyte diaphragm A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates. got7fsn_ti nephrocyte junction cellular_component owl:Class
GO:0033292 biolink:NamedThing T-tubule organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of the T-tubule. A T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. got7fsn_ti transverse tubule organization|T-tubule organisation|T-tubule organization and biogenesis biological_process owl:Class
GO:0055001 biolink:NamedThing muscle cell development The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate. got7fsn_ti muscle fiber development|myofibre development|myofiber development|muscle fibre development GO:0048747 biological_process owl:Class
GO:0046972 biolink:NamedThing histone acetyltransferase activity (H4-K16 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4. got7fsn_ti histone lysine acetyltransferase activity (H4-K16 specific) molecular_function owl:Class
GO:0043984 biolink:NamedThing histone H4-K16 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone. got7fsn_ti histone H4 acetylation at K16 biological_process owl:Class
GO:0055014 biolink:NamedThing atrial cardiac muscle cell development The process whose specific outcome is the progression of an atrial cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ. got7fsn_ti atrial cardiomyocyte development|atrial heart muscle development biological_process owl:Class
GO:0055011 biolink:NamedThing atrial cardiac muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a cardiac muscle cell in the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The atrium is the part of the heart that receives blood into the organ. got7fsn_ti atrial heart muscle cell differentiation|atrial cardiomyocyte differentiation biological_process owl:Class
GO:0090131 biolink:NamedThing mesenchyme migration The process in which the population of cells that make up a mesenchyme undergo directed movement. got7fsn_ti tb 2009-12-07T03:15:17Z biological_process owl:Class
GO:0097006 biolink:NamedThing regulation of plasma lipoprotein particle levels Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism. got7fsn_ti plasma lipoprotein particle homeostasis pr 2011-03-15T09:52:53Z biological_process owl:Class
GO:0004694 biolink:NamedThing eukaryotic translation initiation factor 2alpha kinase activity Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. got7fsn_ti molecular_function owl:Class
GO:0002552 biolink:NamedThing serotonin secretion by mast cell The regulated release of serotonin by a mast cell or group of mast cells. got7fsn_ti serotonin release by mast cell biological_process owl:Class
GO:0046536 biolink:NamedThing dosage compensation complex A protein or protein-RNA complex that localizes to one or more of the sex chromosome(s), where it acts to normalize transcription between different sexes. got7fsn_ti cellular_component owl:Class
GO:0048593 biolink:NamedThing camera-type eye morphogenesis The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. got7fsn_ti camera-style eye morphogenesis GO:0048595|GO:0048594 biological_process owl:Class
GO:0061841 biolink:NamedThing high-affinity iron exporter complex A protein complex which transports ferrous iron (Fe(III) or Fe3+) ions from the vacuole, the main storage component of intracellular free iron, into the cytoplasm in a low iron environment. got7fsn_ti high affinity iron exporter complex|FET5-FTH1 high affinity iron exporter complex|FET5-FTH1 high-affinity iron exporter complex An example of this is FET5 in Saccharomyces cerevisiae (P43561) in PMID:9413439. cellular_component owl:Class
GO:0030867 biolink:NamedThing rough endoplasmic reticulum membrane The lipid bilayer surrounding the rough endoplasmic reticulum. got7fsn_ti RER membrane|rough ER membrane NIF_Subcellular:sao3089754107 cellular_component owl:Class
GO:0070971 biolink:NamedThing endoplasmic reticulum exit site An endoplasmic reticulum part at which COPII-coated vesicles are produced. got7fsn_ti ER exit site|transitional ER mah 2009-10-02T12:19:23Z NIF_Subcellular:sao124393998 cellular_component owl:Class
GO:0010062 biolink:NamedThing negative regulation of trichoblast fate specification Any process that suppresses trichoblast fate specification. got7fsn_ti downregulation of trichoblast fate|inhibition of trichoblast fate|down regulation of trichoblast fate|down-regulation of trichoblast fate biological_process owl:Class
GO:0090627 biolink:NamedThing plant epidermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell. got7fsn_ti tb 2015-02-05T14:23:28Z biological_process owl:Class
GO:0000379 biolink:NamedThing tRNA-type intron splice site recognition and cleavage RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs. got7fsn_ti biological_process owl:Class
GO:0006388 biolink:NamedThing tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. got7fsn_ti tRNA-Y splicing Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. biological_process owl:Class
GO:0007477 biolink:NamedThing notum development The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0030878 biolink:NamedThing thyroid gland development The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. got7fsn_ti biological_process owl:Class
GO:0045122 biolink:NamedThing aflatoxin biosynthetic process The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. got7fsn_ti aflatoxin synthesis|aflatoxin anabolism|aflatoxin biosynthesis|aflatoxin formation biological_process owl:Class
GO:0042469 biolink:NamedThing versicolorin reductase activity Catalysis of the reduction of versicolorin A to sterigmatocystin. got7fsn_ti molecular_function owl:Class
GO:0055087 biolink:NamedThing Ski complex A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p. got7fsn_ti Wikipedia:Ski_complex cellular_component owl:Class
GO:0061229 biolink:NamedThing mesonephric juxtaglomerulus cell development The process whose specific outcome is the progression of a mesonephric juxtaglomerulus cell over time, from its formation to the mature structure. got7fsn_ti dph 2010-08-19T02:34:25Z biological_process owl:Class
GO:0061207 biolink:NamedThing mesonephric juxtaglomerulus cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the mesonephros as it progresses from its formation to the mature state. got7fsn_ti dph 2010-08-19T12:54:08Z biological_process owl:Class
GO:1903187 biolink:NamedThing negative regulation of vitellogenesis Any process that stops, prevents or reduces the frequency, rate or extent of vitellogenesis. got7fsn_ti inhibition of vitellogenesis|inhibition of yolk production|downregulation of vitellogenesis|down regulation of yolk production|down-regulation of yolk production|down regulation of vitellogenesis|downregulation of yolk production|down-regulation of vitellogenesis|negative regulation of yolk production mr 2014-07-14T19:28:06Z biological_process owl:Class
GO:0060437 biolink:NamedThing lung growth The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. got7fsn_ti biological_process owl:Class
GO:0001123 biolink:NamedThing transcription initiation from bacterial-type RNA polymerase promoter Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. got7fsn_ti krc 2010-12-06T03:40:12Z biological_process owl:Class
GO:0015629 biolink:NamedThing actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. got7fsn_ti cellular_component owl:Class
GO:0000079 biolink:NamedThing regulation of cyclin-dependent protein serine/threonine kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. got7fsn_ti regulation of cyclin-dependent protein kinase activity|regulation of CDK activity biological_process owl:Class
GO:0032543 biolink:NamedThing mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. got7fsn_ti mitochondrial protein synthesis|mitochondrial protein biosynthesis|mitochondrial protein anabolism|mitochondrial protein translation|mitochondrial protein formation biological_process owl:Class
GO:0000137 biolink:NamedThing Golgi cis cisterna The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER. got7fsn_ti cellular_component owl:Class
GO:0090317 biolink:NamedThing negative regulation of intracellular protein transport Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells. got7fsn_ti tb 2010-04-16T03:45:07Z biological_process owl:Class
GO:1901667 biolink:NamedThing negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell activation involved in skeletal muscle regeneration. got7fsn_ti down-regulation of satellite cell activation involved in skeletal muscle regeneration|inhibition of satellite cell activation involved in skeletal muscle regeneration|down regulation of satellite cell activation involved in skeletal muscle regeneration|downregulation of satellite cell activation involved in skeletal muscle regeneration dph 2012-11-21T16:21:11Z biological_process owl:Class
GO:0034462 biolink:NamedThing small-subunit processome assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a small-subunit processome. got7fsn_ti small subunit processome assembly|SSU processome assembly biological_process owl:Class
GO:0000028 biolink:NamedThing ribosomal small subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit. got7fsn_ti 30S ribosomal subunit assembly|40S ribosomal subunit assembly biological_process owl:Class
GO:0089721 biolink:NamedThing phosphoenolpyruvate transmembrane transporter activity Enables the transfer of a phosphoenolpyruvate from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0089722 biolink:NamedThing phosphoenolpyruvate transmembrane transport The directed movement of phosphoenolpytuvate across a membrane. got7fsn_ti biological_process owl:Class
GO:0043325 biolink:NamedThing phosphatidylinositol-3,4-bisphosphate binding Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. got7fsn_ti molecular_function owl:Class
NCBITaxon:6231 biolink:NamedThing got7fsn_ti owl:Class
GO:0110078 biolink:NamedThing TTT complex A protein complex responsible for the stabilisation of protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex can also be found as part of the ASTRA complex (GO:0070209). got7fsn_ti Tel2-Tti1-Tti2|Triple T complex|TELO2-TTI1-TTI2 kmv 2018-01-29T21:39:52Z cellular_component owl:Class
GO:0050821 biolink:NamedThing protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. got7fsn_ti protein stabilization activity|protein sequestering|protein stabilisation|positive regulation of protein stability|lysosomal protein stabilization biological_process owl:Class
GO:0097268 biolink:NamedThing cytoophidium A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human. got7fsn_ti pr 2012-03-15T01:00:20Z cellular_component owl:Class
CL:0000000 biolink:NamedThing got7fsn_ti owl:Class
GO:0003157 biolink:NamedThing endocardium development The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. got7fsn_ti dph 2009-10-01T12:42:27Z biological_process owl:Class
GO:0061697 biolink:NamedThing protein-glutaryllysine deglutarylase activity Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. got7fsn_ti This reaction is the removal of a glutaryl group from a glutarylated lysine residue of a protein or peptide. dph 2015-05-07T10:55:53Z RHEA:47664 molecular_function owl:Class
GO:0061699 biolink:NamedThing peptidyl-lysine deglutarylation The removal of a glutaryl group (CO-CH2-CH2--CH2-CO) from a glutarylated lysine residue in a peptide or protein. got7fsn_ti dph 2015-05-07T11:04:42Z biological_process owl:Class
GO:0061075 biolink:NamedThing positive regulation of neural retina development Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. got7fsn_ti dph 2010-03-16T11:59:48Z biological_process owl:Class
GO:0060041 biolink:NamedThing retina development in camera-type eye The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. got7fsn_ti retina development in camera-style eye|retinal development GO:0002073 biological_process owl:Class
CHEBI:3098 biolink:NamedThing got7fsn_ti owl:Class
GO:0140266 biolink:NamedThing Woronin body Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes. got7fsn_ti pg 2018-09-24T14:53:37Z cellular_component owl:Class
NCBITaxon:4890 biolink:NamedThing got7fsn_ti owl:Class
GO:0032821 biolink:NamedThing negative regulation of natural killer cell proliferation involved in immune response Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response. got7fsn_ti down regulation of natural killer cell proliferation during immune response|negative regulation of NK cell proliferation during immune response|negative regulation of natural killer cell proliferation during immune response|downregulation of natural killer cell proliferation during immune response|down-regulation of natural killer cell proliferation during immune response|inhibition of natural killer cell proliferation during immune response biological_process owl:Class
GO:0016198 biolink:NamedThing axon choice point recognition The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth. got7fsn_ti biological_process owl:Class
GO:0005862 biolink:NamedThing muscle thin filament tropomyosin A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments. got7fsn_ti cellular_component owl:Class
GO:0005823 biolink:NamedThing central plaque of spindle pole body One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope. got7fsn_ti cellular_component owl:Class
GO:0031913 biolink:NamedThing contractile vacuole pore Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium. got7fsn_ti cellular_component owl:Class
GO:0007606 biolink:NamedThing sensory perception of chemical stimulus The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti chemosensory perception biological_process owl:Class
GO:1990198 biolink:NamedThing ModE complex A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism. got7fsn_ti ModE dimer bhm 2013-10-01T07:28:52Z cellular_component owl:Class
GO:0080143 biolink:NamedThing regulation of amino acid export Any process that modulates the frequency, rate or extent of amino acid export. Amino acid export is the directed movement of amino acids out of a cell or organelle. got7fsn_ti dhl 2010-01-20T04:43:56Z biological_process owl:Class
GO:0032973 biolink:NamedThing amino acid export across plasma membrane The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region. got7fsn_ti amino acid export|amino acid transmembrane export|amino acid efflux jl 2012-11-14T14:27:40Z GO:0044746 biological_process owl:Class
GO:1903593 biolink:NamedThing regulation of histamine secretion by mast cell Any process that modulates the frequency, rate or extent of histamine secretion by mast cell. got7fsn_ti als 2014-11-06T13:19:09Z biological_process owl:Class
GO:0006954 biolink:NamedThing inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. got7fsn_ti inflammation Wikipedia:Inflammation biological_process owl:Class
GO:0071712 biolink:NamedThing ER-associated misfolded protein catabolic process The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. got7fsn_ti ER-associated misfolded protein catabolism|proteasomal protein catabolism of misfolded ER proteins|endoplasmic reticulum-associated misfolded protein catabolic process|ER-associated misfolded protein breakdown|endoplasmic reticulum-associated misfolded protein catabolism|ER-associated misfolded protein degradation See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. mah 2010-03-10T12:53:27Z biological_process owl:Class
GO:0071218 biolink:NamedThing cellular response to misfolded protein Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. got7fsn_ti mah 2009-12-03T01:17:46Z biological_process owl:Class
GO:0009758 biolink:NamedThing carbohydrate utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism. got7fsn_ti sugar utilization GO:0007587 biological_process owl:Class
GO:0007474 biolink:NamedThing imaginal disc-derived wing vein specification The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified. got7fsn_ti wing vein specification biological_process owl:Class
GO:0043009 biolink:NamedThing chordate embryonic development The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching. got7fsn_ti biological_process owl:Class
GO:0000178 biolink:NamedThing exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. got7fsn_ti exosome (ribonucleasease complex)|exosome multienzyme ribonuclease complex Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. cellular_component owl:Class
GO:0001057 biolink:NamedThing RNA polymerase IV activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter krc 2010-09-23T03:44:55Z molecular_function owl:Class
GO:0071054 biolink:NamedThing alpha9-beta1 integrin-ADAM3 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM3. got7fsn_ti ITGA9-ITGB1-ADAM3 complex mah 2009-11-03T03:59:02Z cellular_component owl:Class
CL:0000187 biolink:NamedThing got7fsn_ti owl:Class
GO:0070934 biolink:NamedThing CRD-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with a sequence in the open reading frame called the coding region instability determinant (CRD). got7fsn_ti coding region determinant-mediated mRNA stabilization mah 2009-09-21T02:57:06Z biological_process owl:Class
GO:0060261 biolink:NamedThing positive regulation of transcription initiation from RNA polymerase II promoter Any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. got7fsn_ti biological_process owl:Class
GO:0061145 biolink:NamedThing lung smooth muscle development The process whose specific outcome is the progression of smooth muscle in the lung over time, from its formation to the mature structure. got7fsn_ti dph 2010-05-25T10:46:35Z biological_process owl:Class
GO:0060809 biolink:NamedThing mesodermal to mesenchymal transition involved in gastrulation The epithelial to mesenchymal transition process in which a mesodermal cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell as part of the process of gastrulation. got7fsn_ti dph 2009-08-06T02:42:09Z biological_process owl:Class
GO:0007369 biolink:NamedThing gastrulation A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. got7fsn_ti Wikipedia:Gastrulation biological_process owl:Class
GO:0045273 biolink:NamedThing respiratory chain complex II A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. got7fsn_ti electron transport complex II cellular_component owl:Class
GO:0045147 biolink:NamedThing regulation of initiation of acetate catabolic process by acetate Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. got7fsn_ti regulation of initiation of acetate breakdown by acetate|regulation of initiation of acetate degradation by acetate biological_process owl:Class
GO:0010034 biolink:NamedThing response to acetate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. got7fsn_ti biological_process owl:Class
GO:2000552 biolink:NamedThing negative regulation of T-helper 2 cell cytokine production Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production. got7fsn_ti negative regulation of Th2 cell cytokine production ebc 2011-04-03T07:32:54Z biological_process owl:Class
GO:0042878 biolink:NamedThing D-glucarate transmembrane transporter activity Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042870 biolink:NamedThing D-glucarate transmembrane transport The process in which D-glucarate, the D-enantiomer of glucarate, is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti D-glucarate transport biological_process owl:Class
GO:0002777 biolink:NamedThing antimicrobial peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa. got7fsn_ti biological_process owl:Class
GO:0043704 biolink:NamedThing photoreceptor cell fate specification The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0046552 biolink:NamedThing photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. got7fsn_ti biological_process owl:Class
GO:0090730 biolink:NamedThing Las1 complex A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448). got7fsn_ti Las1-Grc3-Rat1-Rai1 tb 2017-01-05T16:51:46Z cellular_component owl:Class
GO:0120279 biolink:NamedThing Z granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells that are distinct from, but colocalize with or are adjacent to, P granules and mutator foci and are associated with RNA metabolism. Z granules have been observed in C. elegans. got7fsn_ti germline granule https://github.com/geneontology/go-ontology/issues/20108 krc 2020-10-21T18:27:05Z cellular_component owl:Class
GO:0097447 biolink:NamedThing dendritic tree The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches. got7fsn_ti pr 2012-12-17T12:31:49Z NIF_Subcellular:sao172297168 cellular_component owl:Class
GO:0006368 biolink:NamedThing transcription elongation from RNA polymerase II promoter The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. got7fsn_ti RNA polymerase II transcription elongation factor activity|RNA elongation from Pol II promoter biological_process owl:Class
GO:0021768 biolink:NamedThing nucleus accumbens development The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia. got7fsn_ti ventral striatum development|accumbens nucleus development biological_process owl:Class
GO:0021756 biolink:NamedThing striatum development The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati. got7fsn_ti striate nucleus development|neostriatum development biological_process owl:Class
GO:1905318 biolink:NamedThing meiosis I spindle assembly checkpoint signaling Any spindle assembly checkpoint that is involved in meiosis I. got7fsn_ti meiosis I spindle assembly checkpoint https://github.com/geneontology/go-ontology/issues/20935 vw 2016-07-13T18:25:06Z biological_process owl:Class
GO:0097564 biolink:NamedThing right lateral basal body pair Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally. got7fsn_ti Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T16:12:42Z cellular_component owl:Class
GO:1902676 biolink:NamedThing right ventral basal body Any ciliary basal body that is part of a right ventral flagellum found in Giardia species (trophozoite stage). got7fsn_ti cilium basal body of right ventral flagellum|right ventral flagellum ciliary basal body|cilial basal body of right ventral flagellum|ciliary basal body of right ventral flagellum|cilium basal body of right ventral cilium|ciliary basal body of right ventral cilium|microtubule basal body of right ventral flagellum|microtubule basal body of right ventral cilium|cilial basal body of right ventral cilium Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T14:58:13Z cellular_component owl:Class
GO:0005930 biolink:NamedThing axoneme The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. got7fsn_ti ciliary axoneme|flagellum axoneme|flagellar axoneme|cilium axoneme Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. GO:0035085|GO:0035086 Wikipedia:Axoneme cellular_component owl:Class
GO:0005874 biolink:NamedThing microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. got7fsn_ti microtubulus|microtubuli|neurotubule NIF_Subcellular:sao1846835077|Wikipedia:Microtubule cellular_component owl:Class
GO:0032465 biolink:NamedThing regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. got7fsn_ti regulation of cell cycle cytokinesis GO:0071775 biological_process owl:Class
GO:0060615 biolink:NamedThing mammary gland bud formation The morphogenetic process in which a bud forms from the mammary placode. A mammary bud is bulb of epithelial cells that is distinct from the surrounding epidermis. got7fsn_ti dph 2009-05-18T08:43:14Z biological_process owl:Class
GO:0052929 biolink:NamedThing ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity Catalysis of the reaction: a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate. got7fsn_ti ATP:3'-CC-tRNA adenylyltransferase activity|ATP:tRNA adenylyltransferase activity EC:2.7.7.72|KEGG_REACTION:R09386|RHEA:60012 molecular_function owl:Class
GO:0004623 biolink:NamedThing phospholipase A2 activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. got7fsn_ti phosphatidase activity|lecithinase A activity|cytosolic phospholipase A2 activity|phosphatidolipase activity|secreted phospholipase A2 activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|phosphatidylcholine 2-acylhydrolase activity https://github.com/geneontology/go-ontology/issues/21259 GO:0102568|GO:0102567 Reactome:R-HSA-1482604|Reactome:R-HSA-1482907|RHEA:15801|Reactome:R-HSA-1482856|MetaCyc:RXN-15067|Reactome:R-HSA-1482897|Reactome:R-HSA-1602399|Reactome:R-HSA-1602374|Reactome:R-HSA-1602377|Reactome:R-HSA-1482884|Reactome:R-HSA-1482679|Reactome:R-HSA-1602417|Reactome:R-HSA-1482825|Reactome:R-HSA-1482745|Reactome:R-HSA-1482900|Reactome:R-HSA-1482771|Reactome:R-HSA-1602398|Reactome:R-HSA-1482816|Reactome:R-HSA-1602446|Reactome:R-HSA-8848484|Reactome:R-HSA-1482759|Reactome:R-HSA-1482656|Reactome:R-HSA-1482868|EC:3.1.1.4|Reactome:R-HSA-1482776|MetaCyc:RXN-15065|Reactome:R-HSA-1602368|MetaCyc:PHOSPHOLIPASE-A2-RXN|Reactome:R-HSA-1482778|Reactome:R-HSA-1482887 molecular_function owl:Class
GO:0019776 biolink:NamedThing Atg8 ligase activity Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate. got7fsn_ti APG8 conjugating enzyme activity|Atg8 conjugating enzyme activity|APG8 ligase activity Reactome:R-HSA-5681981 molecular_function owl:Class
GO:0019071 biolink:NamedThing viral DNA cleavage involved in viral genome maturation The cleavage of viral DNA into singular functional units. got7fsn_ti biological_process owl:Class
GO:0001771 biolink:NamedThing immunological synapse formation The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. got7fsn_ti formation of immunological synapse biological_process owl:Class
GO:0035309 biolink:NamedThing wing and notum subfield formation The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures. got7fsn_ti biological_process owl:Class
GO:0009854 biolink:NamedThing oxidative photosynthetic carbon pathway The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2). got7fsn_ti biological_process owl:Class
GO:0001885 biolink:NamedThing endothelial cell development The progression of an endothelial cell over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0003158 biolink:NamedThing endothelium development The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells. got7fsn_ti dph 2009-10-01T12:50:57Z biological_process owl:Class
GO:1901030 biolink:NamedThing positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. got7fsn_ti up regulation of mitochondrial outer membrane permeabilization|positive regulation of MOMP|up regulation of MOMP|positive regulation of mitochondrial outer membrane permeabilization|upregulation of mitochondrial outer membrane permeabilization|up-regulation of MOMP|upregulation of MOMP|up-regulation of mitochondrial outer membrane permeabilization|activation of mitochondrial outer membrane permeabilization|activation of MOMP Caspase 8 may be annotated to this term when it is shown to stimulate MOMP by cleaving the BH3-only protein BID. pr 2012-06-20T09:19:46Z biological_process owl:Class
GO:0021988 biolink:NamedThing olfactory lobe development The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell. got7fsn_ti biological_process owl:Class
GO:1990718 biolink:NamedThing axonemal central pair projection Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules. got7fsn_ti krc 2015-03-27T22:43:01Z cellular_component owl:Class
GO:1990716 biolink:NamedThing axonemal central apparatus Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules. got7fsn_ti krc 2015-03-27T22:33:23Z cellular_component owl:Class
GO:0001542 biolink:NamedThing ovulation from ovarian follicle The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus. got7fsn_ti biological_process owl:Class
GO:0008585 biolink:NamedThing female gonad development The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure. got7fsn_ti ovarian development|ovary development GO:0061039 biological_process owl:Class
GO:0008290 biolink:NamedThing F-actin capping protein complex A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. got7fsn_ti cellular_component owl:Class
GO:0086057 biolink:NamedThing voltage-gated calcium channel activity involved in bundle of His cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated calcium channel activity involved in bundle of His cardiac muscle cell action potential dph 2011-11-17T12:32:51Z molecular_function owl:Class
GO:0086048 biolink:NamedThing membrane depolarization during bundle of His cell action potential The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti membrane depolarization during bundle of His cardiac muscle cell action potential dph 2011-11-16T10:56:26Z biological_process owl:Class
GO:0002898 biolink:NamedThing regulation of central B cell deletion Any process that modulates the frequency, rate, or extent of central B cell deletion. got7fsn_ti biological_process owl:Class
GO:1900118 biolink:NamedThing negative regulation of execution phase of apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis. got7fsn_ti down regulation of execution phase of apoptosis|down-regulation of execution phase of apoptosis|downregulation of execution phase of apoptosis|inhibition of execution phase of apoptosis pr 2012-02-22T11:26:24Z biological_process owl:Class
GO:0030874 biolink:NamedThing nucleolar chromatin The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA. got7fsn_ti cellular_component owl:Class
GO:0000228 biolink:NamedThing nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. got7fsn_ti nuclear interphase chromosome cellular_component owl:Class
GO:0060102 biolink:NamedThing collagen and cuticulin-based cuticle extracellular matrix A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans. got7fsn_ti collagen and cuticulin-based exoskeleton extracellular matrix cellular_component owl:Class
NCBITaxon:33213 biolink:NamedThing got7fsn_ti owl:Class
CL:0000018 biolink:NamedThing got7fsn_ti owl:Class
GO:0090558 biolink:NamedThing plant epidermis development The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure. got7fsn_ti tb 2014-02-27T15:17:37Z biological_process owl:Class
GO:0000022 biolink:NamedThing mitotic spindle elongation The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B. got7fsn_ti microtubule sliding involved in mitotic spindle elongation|spindle elongation during mitosis pr 2016-04-08T15:06:14Z GO:1905121 biological_process owl:Class
GO:0048080 biolink:NamedThing negative regulation of cuticle pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. got7fsn_ti down regulation of cuticle pigmentation|inhibition of cuticle pigmentation|down-regulation of cuticle pigmentation|downregulation of cuticle pigmentation biological_process owl:Class
GO:1903669 biolink:NamedThing positive regulation of chemorepellent activity Any process that activates or increases the frequency, rate or extent of chemorepellent activity. got7fsn_ti activation of chemorepellent activity|positive regulation of chemorepellant activity|up-regulation of chemorepellant activity|upregulation of chemorepellent activity|up-regulation of chemorepellent activity|up regulation of chemorepellent activity|activation of chemorepellant activity|up regulation of chemorepellant activity|upregulation of chemorepellant activity pf 2014-11-26T23:58:50Z biological_process owl:Class
NCBITaxon:7203 biolink:NamedThing got7fsn_ti owl:Class
GO:0009549 biolink:NamedThing cellulose microfibril A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell. got7fsn_ti cellular_component owl:Class
GO:0009912 biolink:NamedThing auditory receptor cell fate commitment The process in which the cellular identity of auditory hair cells is acquired and determined. got7fsn_ti auditory hair cell fate commitment biological_process owl:Class
GO:0042491 biolink:NamedThing inner ear auditory receptor cell differentiation The process in which a relatively unspecialized inner cell acquires specialized features of an auditory hair cell. got7fsn_ti auditory hair cell differentiation|auditory receptor cell differentiation Note that this term refers to the mechanosensory hair cells of the inner ear. biological_process owl:Class
GO:0035215 biolink:NamedThing genital disc development Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia. got7fsn_ti biological_process owl:Class
GO:0031521 biolink:NamedThing spitzenkorper Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments. got7fsn_ti cellular_component owl:Class
GO:0001411 biolink:NamedThing hyphal tip The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation. got7fsn_ti cellular_component owl:Class
GO:1990879 biolink:NamedThing CST complex A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection. got7fsn_ti CTC1-OBFC1-TEN1 complex|Cdc13-Stn1-Ten1 complex nc 2015-10-20T13:51:07Z cellular_component owl:Class
GO:0009986 biolink:NamedThing cell surface The external part of the cell wall and/or plasma membrane. got7fsn_ti cell bound|cell associated Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall. GO:0009929|GO:0009928 cellular_component owl:Class
GO:1903329 biolink:NamedThing regulation of iron-sulfur cluster assembly Any process that modulates the frequency, rate or extent of iron-sulfur cluster assembly. got7fsn_ti vw 2014-08-18T13:12:41Z biological_process owl:Class
GO:1903622 biolink:NamedThing regulation of RNA polymerase III activity Any process that modulates the frequency, rate or extent of RNA polymerase III activity. got7fsn_ti regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter al 2014-11-19T18:24:29Z biological_process owl:Class
GO:0071128 biolink:NamedThing alpha5-beta1 integrin-osteopontin complex A protein complex that consists of an alpha5-beta1 integrin complex bound to osteopontin. got7fsn_ti ITGA5-ITGB1-SPP1 complex mah 2009-11-13T02:24:43Z cellular_component owl:Class
GO:0033573 biolink:NamedThing high-affinity iron permease complex A protein complex composed of a multicopper ferroxidase that oxidizes Fe(II) to Fe(III), and a ferric iron permease that transports the produced Fe(III) into the cell. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity iron permease complex cellular_component owl:Class
GO:0055044 biolink:NamedThing symplast The interconnected cell membranes and intracellular regions of a plant. The interconnections occur via the plasmodesmata. got7fsn_ti Wikipedia:Symplast cellular_component owl:Class
GO:0042898 biolink:NamedThing fosmidomycin transmembrane transporter activity Enables the transfer of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, from one side of a membrane to the other. got7fsn_ti fosmidomycin transporter activity molecular_function owl:Class
GO:0042894 biolink:NamedThing fosmidomycin transport The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0048750 biolink:NamedThing compound eye corneal lens morphogenesis The process in which the anatomical structures of the compound eye corneal lens are generated and organized. got7fsn_ti biological_process owl:Class
GO:0043679 biolink:NamedThing axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it. got7fsn_ti nerve ending|axon terminal|axon terminal specialization NIF_Subcellular:nlx_subcell_20090512 cellular_component owl:Class
GO:0050920 biolink:NamedThing regulation of chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. got7fsn_ti biological_process owl:Class
GO:0045779 biolink:NamedThing negative regulation of bone resorption Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption. got7fsn_ti inhibition of bone resorption|down-regulation of bone resorption|downregulation of bone resorption|down regulation of bone resorption biological_process owl:Class
GO:1903133 biolink:NamedThing negative regulation of tube lumen cavitation Any process that stops, prevents or reduces the frequency, rate or extent of tube lumen cavitation. got7fsn_ti inhibition of tube lumen cavitation dph 2014-06-25T20:19:04Z biological_process owl:Class
GO:0035153 biolink:NamedThing epithelial cell type specification, open tracheal system Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions. got7fsn_ti tracheal cell type specification|tracheal epithelial cell type specification biological_process owl:Class
GO:1990717 biolink:NamedThing axonemal central bridge Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules. got7fsn_ti krc 2015-03-27T22:38:31Z cellular_component owl:Class
GO:0044154 biolink:NamedThing histone H3-K14 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone. got7fsn_ti histone H3 acetylation at K14|histone H3K14 acetylation jl 2009-08-11T03:40:43Z biological_process owl:Class
GO:0001833 biolink:NamedThing inner cell mass cell proliferation The proliferation of cells in the inner cell mass. got7fsn_ti See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. biological_process owl:Class
GO:0001832 biolink:NamedThing blastocyst growth An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation. got7fsn_ti See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. biological_process owl:Class
GO:0061357 biolink:NamedThing positive regulation of Wnt protein secretion Any process that activates or increases the frequency, rate or extent of the controlled release of a Wnt protein from a cell. got7fsn_ti dph 2010-10-08T01:12:21Z biological_process owl:Class
GO:0023052 biolink:NamedThing signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. got7fsn_ti signalling|signalling process|signaling process|single organism signaling|biological signaling Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. jl 2010-02-16T09:30:50Z GO:0044700|GO:0023046 biological_process owl:Class
GO:0043672 biolink:NamedThing nexine The inner, non-sculptured part of the exine which lies below the sexine. got7fsn_ti Note that nexine is distinguished on purely morphological criteria; compare with 'endexine ; GO:0043671'. See also 'sexine ; GO:0043673'. cellular_component owl:Class
GO:0030096 biolink:NamedThing plasma membrane-derived thylakoid photosystem II A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone. got7fsn_ti plasma membrane photosystem II cellular_component owl:Class
GO:0010197 biolink:NamedThing polar nucleus fusion The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized. got7fsn_ti biological_process owl:Class
GO:1990058 biolink:NamedThing fruit replum development The process whose specific outcome is the progression of the fruit replum over time, from its formation to the mature structure. The fruit replum is a portion of fruit placenta tissue that divides a fruit into two or more chambers and develops from a replum. got7fsn_ti dhl 2013-03-12T21:15:15Z biological_process owl:Class
GO:1903905 biolink:NamedThing positive regulation of establishment of T cell polarity Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity. got7fsn_ti upregulation of establishment of T-cell polarity|activation of T lymphocyte polarization|upregulation of T cell polarization|upregulation of establishment of T lymphocyte polarity|positive regulation of establishment of T-lymphocyte polarity|up regulation of T lymphocyte polarization|up-regulation of establishment of T-cell polarity|upregulation of establishment of T cell polarity|up-regulation of T lymphocyte polarization|positive regulation of establishment of T lymphocyte polarity|up-regulation of T cell polarization|up regulation of T-cell polarization|positive regulation of establishment of T-cell polarity|activation of establishment of T-lymphocyte polarity|upregulation of establishment of T-lymphocyte polarity|up regulation of establishment of T lymphocyte polarity|activation of establishment of T cell polarity|up regulation of T cell polarization|up-regulation of establishment of T-lymphocyte polarity|upregulation of T-cell polarization|upregulation of T lymphocyte polarization|positive regulation of T cell polarization|up regulation of establishment of T-cell polarity|up-regulation of T-cell polarization|activation of establishment of T lymphocyte polarity|up-regulation of establishment of T lymphocyte polarity|positive regulation of T lymphocyte polarization|positive regulation of T-cell polarization|up regulation of establishment of T cell polarity|up-regulation of establishment of T cell polarity|activation of T cell polarization|activation of establishment of T-cell polarity|activation of T-cell polarization|up regulation of establishment of T-lymphocyte polarity als 2015-02-09T10:50:40Z biological_process owl:Class
GO:1990316 biolink:NamedThing Atg1/ULK1 kinase complex A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. got7fsn_ti ULK1 signaling complex|ULK1 complex|autophagy-initiation complex|ATG1/ULK1 signaling complex|ULK1-ATG13-FIP200 complex|ULK complex|Atg1p signalling complex|ATG1-ATG13 complex|ULK1-ATG13-RB1CC1 complex|ATG1 kinase complex bhm 2014-03-14T10:55:11Z GO:0034273|GO:0070969 cellular_component owl:Class
GO:0003192 biolink:NamedThing mitral valve formation The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti dph 2009-10-08T01:10:19Z biological_process owl:Class
GO:0003183 biolink:NamedThing mitral valve morphogenesis The process in which the structure of the mitral valve is generated and organized. got7fsn_ti dph 2009-10-08T12:02:01Z biological_process owl:Class
GO:1990662 biolink:NamedThing S100A9 complex A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility. got7fsn_ti S100A9 homodimer An example of this is S100A9 in human (UniProt symbol P06702) in PMID:15642721 (inferred from direct assay). bhm 2015-02-25T15:55:48Z cellular_component owl:Class
GO:0035662 biolink:NamedThing Toll-like receptor 4 binding Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. got7fsn_ti TLR4 binding bf 2011-02-01T10:20:59Z molecular_function owl:Class
GO:1901233 biolink:NamedThing negative regulation of convergent extension involved in axis elongation Any process that stops, prevents or reduces the frequency, rate or extent of convergent extension involved in axis elongation. got7fsn_ti downregulation of convergent extension involved in axis elongation|inhibition of convergent extension involved in axis elongation|down-regulation of convergent extension involved in axis elongation|down regulation of convergent extension involved in axis elongation vk 2012-08-07T14:22:11Z biological_process owl:Class
GO:0048546 biolink:NamedThing digestive tract morphogenesis The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. got7fsn_ti gut morphogenesis|intestinal morphogenesis|gastrointestinal tract morphogenesis|alimentary canal morphogenesis|digestive tube morphogenesis GO:0048547 biological_process owl:Class
GO:0021547 biolink:NamedThing midbrain-hindbrain boundary initiation The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. got7fsn_ti isthmus formation|isthmus biosynthesis|midbrain-hindbrain boundary biosynthesis|midbrain-hindbrain boundary formation|MHB formation|MHB biosynthesis biological_process owl:Class
GO:0060478 biolink:NamedThing acrosomal vesicle exocytosis The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction. got7fsn_ti acrosomal granule exocytosis|acrosome exocytosis biological_process owl:Class
GO:0007340 biolink:NamedThing acrosome reaction The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida. got7fsn_ti If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss. Wikipedia:Acrosome_reaction biological_process owl:Class
GO:0070899 biolink:NamedThing mitochondrial tRNA wobble uridine modification The process in which a uridine in position 34 of a mitochondrial tRNA is post-transcriptionally modified. got7fsn_ti mah 2009-09-02T03:14:13Z biological_process owl:Class
GO:0030991 biolink:NamedThing intraciliary transport particle A The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa. got7fsn_ti IFT A complex|intraflagellar transport particle A|IFT complex A|intraflagellar transport complex A Note that we deem cilia and microtubule-based flagella to be equivalent. cellular_component owl:Class
GO:0035720 biolink:NamedThing intraciliary anterograde transport The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins. got7fsn_ti intraflagellar anterograde transport Note that we deem cilium and microtubule-based flagellum to be equivalent. bf 2011-03-07T11:24:53Z biological_process owl:Class
GO:0000281 biolink:NamedThing mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. got7fsn_ti cytokinesis after mitosis biological_process owl:Class
GO:0039532 biolink:NamedThing negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. got7fsn_ti negative regulation of MAVS signaling|negative regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway|negative regulation of cytoplasmic pattern recognition receptor signaling pathway in response to virus bf 2012-01-03T11:14:48Z biological_process owl:Class
GO:0051607 biolink:NamedThing defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism. got7fsn_ti defense response to viruses|defence response to virus|antiviral response biological_process owl:Class
GO:0035550 biolink:NamedThing urease complex A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide). got7fsn_ti Eukaryotic microorganisms, plants, and probably Gram-positive bacteria, possess a homopolymeric urease. In contrast, urease complexes from gram-negative bacteria studied thus far clearly possess three distinct subunits (alpha, beta and gamma). Tightly bound nickel is present in all urease complexes. bf 2010-05-12T01:00:27Z cellular_component owl:Class
GO:0000287 biolink:NamedThing magnesium ion binding Binding to a magnesium (Mg) ion. got7fsn_ti magnesium binding|Mg binding molecular_function owl:Class
GO:0007350 biolink:NamedThing blastoderm segmentation The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo. got7fsn_ti biological_process owl:Class
GO:0061474 biolink:NamedThing phagolysosome membrane The lipid bilayer surrounding a phagolysosome. got7fsn_ti dph 2012-11-06T12:26:18Z cellular_component owl:Class
GO:0036117 biolink:NamedThing hyaluranon cable A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan. got7fsn_ti HA cable bf 2012-02-16T10:53:37Z cellular_component owl:Class
GO:0009548 biolink:NamedThing plasmodesmatal plasma membrane The portion of the plasma membrane surrounding a plasmodesma. got7fsn_ti cellular_component owl:Class
GO:0021612 biolink:NamedThing facial nerve structural organization The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. got7fsn_ti CN VII structural organization|facial nerve structural organisation biological_process owl:Class
GO:0021610 biolink:NamedThing facial nerve morphogenesis The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. got7fsn_ti CN VII morphogenesis biological_process owl:Class
GO:0007080 biolink:NamedThing mitotic metaphase plate congression The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. got7fsn_ti biological_process owl:Class
GO:0031505 biolink:NamedThing fungal-type cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall. got7fsn_ti chitin- and beta-glucan-containing cell wall organization and biogenesis|fungal-type cell wall organization and biogenesis|chitin-containing cell wall organization and biogenesis|beta-glucan-containing cell wall organization and biogenesis|chitin- and beta-glucan-containing cell wall organisation biological_process owl:Class
GO:0009329 biolink:NamedThing acetate CoA-transferase complex A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA. got7fsn_ti cellular_component owl:Class
GO:0005880 biolink:NamedThing nuclear microtubule Any microtubule in the nucleus of a cell. got7fsn_ti cellular_component owl:Class
GO:0030077 biolink:NamedThing plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. got7fsn_ti cellular_component owl:Class
GO:2001235 biolink:NamedThing positive regulation of apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway. got7fsn_ti positive regulation of apoptotic signalling pathway pr 2011-11-24T01:20:58Z biological_process owl:Class
GO:0051331 biolink:NamedThing meiotic G2 phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis. got7fsn_ti G2 phase of meiotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0030717 biolink:NamedThing oocyte karyosome formation The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome. got7fsn_ti biological_process owl:Class
GO:1901028 biolink:NamedThing regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Any process that modulates the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. got7fsn_ti regulation of MOMP|regulation of mitochondrial outer membrane permeabilization pr 2012-06-20T09:19:16Z biological_process owl:Class
GO:0034455 biolink:NamedThing t-UTP complex A protein complex that forms a subcomplex of the 90S preribosome and is required for the subsequent assembly of the rest of the preribosome. In S. cerevisiae, it is composed of Utp5p, Utp4p, Nan1p, Utp8p, Utp9p, Utp10 and Utp15p. got7fsn_ti Nan1p-containing subcomplex of 90S preribosome Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. cellular_component owl:Class
GO:0005730 biolink:NamedThing nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. got7fsn_ti Wikipedia:Nucleolus|NIF_Subcellular:sao1820400233 cellular_component owl:Class
GO:0005654 biolink:NamedThing nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus. got7fsn_ti NIF_Subcellular:sao661522542|Wikipedia:Nucleoplasm cellular_component owl:Class
GO:0039664 biolink:NamedThing lysis of host organelle involved in viral entry into host cell The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm. got7fsn_ti viral membrane-lytic protein|viral entry into host cell via endosome membrane lysis|viral penetration via lysis of host organellar membrane|viral entry into host cell via lysis of host organelle membrane bf 2013-08-29T11:30:18Z VZ:984 biological_process owl:Class
GO:0010097 biolink:NamedThing specification of stamen identity The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0048455 biolink:NamedThing stamen formation The process that contributes to the act of giving rise to the stamen. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048427 biological_process owl:Class
GO:0005701 biolink:NamedThing polytene chromosome chromocenter A region at which the centric regions of polytene chromosomes are joined together. got7fsn_ti polytene chromosome chromocentre cellular_component owl:Class
GO:0045266 biolink:NamedThing plasma membrane proton-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species. got7fsn_ti hydrogen-transporting ATP synthase, stator stalk|proton-transporting ATP synthase, stator stalk cellular_component owl:Class
GO:0045264 biolink:NamedThing plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins. got7fsn_ti proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting ATP synthase complex, coupling factor F(0)|hydrogen-transporting ATP synthase, F0 sector cellular_component owl:Class
GO:0000748 biolink:NamedThing conjugation with mutual genetic exchange A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange. got7fsn_ti conjugation without cellular fusion biological_process owl:Class
NCBITaxon:5878 biolink:NamedThing got7fsn_ti owl:Class
GO:0006948 biolink:NamedThing induction by virus of host cell-cell fusion The process of syncytia-forming cell-cell fusion, caused by a virus. got7fsn_ti viral-induced host cell-cell fusion|viral-induced cell-cell fusion|induction by virus of cell-cell fusion in host|viral-induced membrane fusion Where syncytium formation results in the spread of virus in the host, also consider annotating to the term 'spread of virus in multicellular host ; GO:0046739'. biological_process owl:Class
GO:1903073 biolink:NamedThing negative regulation of death-inducing signaling complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of death-inducing signaling complex assembly. got7fsn_ti negative regulation of DISC assembly|downregulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|downregulation of DD-mediated complex assembly|inhibition of DD-mediated complex assembly|down-regulation of DD-mediated complex assembly|downregulation of DISC formation|down regulation of death-inducing signalling complex assembly|inhibition of DISC formation|down regulation of DISC assembly|down-regulation of DISC assembly|negative regulation of death domain-mediated complex assembly|down-regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|down regulation of DD-mediated complex assembly|inhibition of death-inducing signaling complex formation|negative regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|down regulation of death-inducing signaling complex assembly|inhibition of death-inducing signalling complex assembly|down regulation of death-inducing signaling complex formation|downregulation of death-inducing signalling complex assembly|down-regulation of death-inducing signaling complex formation|negative regulation of DISC formation|inhibition of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|down-regulation of death-inducing signalling complex assembly|downregulation of death-inducing signaling complex assembly|down regulation of death domain-mediated complex assembly involved in extrinsic apoptotic pathway|down regulation of death domain-mediated complex assembly|inhibition of death-inducing signaling complex assembly|down regulation of DISC formation|down-regulation of death domain-mediated complex assembly|negative regulation of death-inducing signaling complex formation|inhibition of DISC assembly|down-regulation of death-inducing signaling complex assembly|downregulation of death domain-mediated complex assembly|down-regulation of DISC formation|downregulation of death-inducing signaling complex formation|downregulation of DISC assembly|inhibition of death domain-mediated complex assembly|negative regulation of death-inducing signalling complex assembly|negative regulation of DD-mediated complex assembly bf 2014-05-29T09:33:20Z biological_process owl:Class
GO:0018990 biolink:NamedThing ecdysis, chitin-based cuticle The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0015109 biolink:NamedThing chromate transmembrane transporter activity Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3. got7fsn_ti RHEA:32819 molecular_function owl:Class
GO:0015703 biolink:NamedThing chromate transport The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0060854 biolink:NamedThing branching involved in lymph vessel morphogenesis The process of the coordinated growth and sprouting of lymph vessels giving rise to the organized lymphatic system. got7fsn_ti patterning of lymph vessels dph 2009-08-12T12:00:48Z biological_process owl:Class
GO:0045143 biolink:NamedThing homologous chromosome segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. got7fsn_ti meiosis I, chromosome segregation GO:0007061 biological_process owl:Class
GO:0042501 biolink:NamedThing serine phosphorylation of STAT protein The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein. got7fsn_ti serine phosphorylation of STAT3 protein GO:0033136 biological_process owl:Class
GO:0046425 biolink:NamedThing regulation of receptor signaling pathway via JAK-STAT Any process that modulates the frequency, rate or extent of receptor signaling via JAK-STAT. got7fsn_ti STAT protein import into nucleus|regulation of STAT protein nuclear translocation|regulation of STAT protein import into nucleus https://github.com/geneontology/go-ontology/issues/13686 GO:2000364|GO:0007262 biological_process owl:Class
GO:0031671 biolink:NamedThing primary cell septum biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division. got7fsn_ti biological_process owl:Class
GO:0140278 biolink:NamedThing mitotic division septum assembly The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following mitotic cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. got7fsn_ti pg 2018-10-08T09:46:11Z biological_process owl:Class
GO:0042584 biolink:NamedThing chromaffin granule membrane The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. got7fsn_ti cellular_component owl:Class
GO:0042583 biolink:NamedThing chromaffin granule Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine. got7fsn_ti cellular_component owl:Class
GO:1900133 biolink:NamedThing regulation of renin secretion into blood stream Any process that modulates the frequency, rate or extent of renin secretion into blood stream. got7fsn_ti regulation of renin release into blood stream rph 2012-02-27T10:32:01Z biological_process owl:Class
GO:0097224 biolink:NamedThing sperm connecting piece The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum. got7fsn_ti pr 2012-01-25T01:21:02Z cellular_component owl:Class
CL:0000019 biolink:NamedThing got7fsn_ti owl:Class
GO:0004001 biolink:NamedThing adenosine kinase activity Catalysis of the reaction: ATP + adenosine = ADP + AMP. got7fsn_ti adenosine kinase (phosphorylating)|adenosine 5-phosphotransferase activity|ATP:adenosine 5'-phosphotransferase activity EC:2.7.1.20|RHEA:20824|Reactome:R-HSA-109624|MetaCyc:ADENOSINE-KINASE-RXN molecular_function owl:Class
GO:0007132 biolink:NamedThing meiotic metaphase I The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0032870 biolink:NamedThing cellular response to hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. got7fsn_ti biological_process owl:Class
GO:0015551 biolink:NamedThing 3-hydroxyphenyl propanoate transmembrane transporter activity Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other. got7fsn_ti 3-hydroxyphenyl propionate transmembrane transporter activity molecular_function owl:Class
GO:0015731 biolink:NamedThing 3-hydroxyphenyl propanoate transport The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti 3-hydroxyphenyl propionate transport biological_process owl:Class
GO:0048850 biolink:NamedThing hypophysis morphogenesis The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands. got7fsn_ti pituitary gland morphogenesis biological_process owl:Class
GO:0070926 biolink:NamedThing regulation of ATP:ADP antiporter activity Any process that modulates the activity of an ATP:ADP antiporter. got7fsn_ti mah 2009-09-16T02:56:35Z biological_process owl:Class
GO:0015931 biolink:NamedThing nucleobase-containing compound transport The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti nucleobase, nucleoside, nucleotide and nucleic acid transport biological_process owl:Class
GO:0043198 biolink:NamedThing dendritic shaft Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. got7fsn_ti trunk NIF_Subcellular:sao2034472720 cellular_component owl:Class
GO:0070565 biolink:NamedThing telomere-telomerase complex A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome. got7fsn_ti Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. mah 2009-04-14T03:07:50Z cellular_component owl:Class
GO:0000781 biolink:NamedThing chromosome, telomeric region The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). got7fsn_ti nuclear chromosome, telomere|telomere|nuclear chromosome, telomeric region Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. GO:0000784 SO:0000624 cellular_component owl:Class
GO:0009901 biolink:NamedThing anther dehiscence The dehiscence of an anther to release the pollen grains contained within it. got7fsn_ti biological_process owl:Class
GO:0007595 biolink:NamedThing lactation The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. got7fsn_ti milk secretion Wikipedia:Lactation biological_process owl:Class
GO:0035014 biolink:NamedThing phosphatidylinositol 3-kinase regulator activity Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. got7fsn_ti PI3K regulator activity|phosphoinositide 3-kinase regulator activity See also the molecular function term 'phosphoinositide 3-kinase activity ; GO:0035004'. molecular_function owl:Class
GO:1901721 biolink:NamedThing positive regulation of NMS complex assembly Any process that activates or increases the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation. got7fsn_ti upregulation of NMS complex association involved in chromosome segregation|upregulation of NMS complex interaction involved in chromosome segregation|positive regulation of NMS complex assembly involved in kinetochore assembly|up regulation of KMN complex interaction involved in chromosome segregation|up-regulation of NMS complex interaction involved in chromosome segregation|up-regulation of NMS complex association involved in chromosome segregation|positive regulation of KMN network assembly involved in chromosome segregation|positive regulation of KMN complex interaction involved in chromosome segregation|upregulation of KMN complex interaction involved in chromosome segregation|up-regulation of KMN complex interaction involved in chromosome segregation|activation of KMN complex assembly involved in chromosome segregation|activation of NMS complex association involved in chromosome segregation|up regulation of KMN network assembly involved in chromosome segregation|up-regulation of KMN network assembly involved in chromosome segregation|activation of NMS complex interaction involved in chromosome segregation|upregulation of KMN network assembly involved in chromosome segregation|up regulation of NMS complex association involved in chromosome segregation|activation of KMN network assembly involved in chromosome segregation|positive regulation of NMS complex association involved in chromosome segregation|up regulation of NMS complex interaction involved in chromosome segregation jl 2012-12-20T11:44:26Z biological_process owl:Class
GO:0051382 biolink:NamedThing kinetochore assembly The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. got7fsn_ti centromere/kinetochore complex maturation|kinetochore formation|centromere and kinetochore complex maturation|chromosome-kinetochore attachment GO:0000069 biological_process owl:Class
GO:0003023 biolink:NamedThing baroreceptor detection of increased arterial stretch The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal. got7fsn_ti biological_process owl:Class
GO:0009190 biolink:NamedThing cyclic nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. got7fsn_ti cyclic nucleotide biosynthesis|cyclic nucleotide anabolism|cyclic nucleotide formation|cyclic nucleotide synthesis biological_process owl:Class
GO:0044084 biolink:NamedThing host cell membrane pore complex Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins. got7fsn_ti pore complex in host cell membrane cellular_component owl:Class
GO:0007534 biolink:NamedThing gene conversion at mating-type locus The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged. got7fsn_ti gene conversion at mating-type locus, DNA double-strand break formation|gene conversion at mating-type locus, DNA double-strand break processing|gene conversion at mating-type locus, termination of copy-synthesis|strand invasion involved in gene conversion at mating-type locus|heteroduplex formation involved in gene conversion at mating-type locus|gene conversion at mating-type locus, DNA repair synthesis https://github.com/geneontology/go-ontology/issues/19999 GO:0031292|GO:0000734|GO:0010708|GO:0061500|GO:0000728|GO:0034636 biological_process owl:Class
GO:0030491 biolink:NamedThing heteroduplex formation The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. got7fsn_ti biological_process owl:Class
GO:0010466 biolink:NamedThing negative regulation of peptidase activity Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins. got7fsn_ti biological_process owl:Class
GO:0021987 biolink:NamedThing cerebral cortex development The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. got7fsn_ti corticogenesis|neocortex development biological_process owl:Class
GO:0004951 biolink:NamedThing cholecystokinin receptor activity Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. got7fsn_ti CCK receptor activity molecular_function owl:Class
GO:0038188 biolink:NamedThing cholecystokinin signaling pathway The series of molecular signals generated as a consequence of cholecystokinin binding to a receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CCK signaling|cholecystokinin receptor signaling pathway bf 2013-07-01T13:05:46Z Wikipedia:Cholecystokinin biological_process owl:Class
GO:0061773 biolink:NamedThing eNoSc complex A chromatin silencing complex that recruits histone-modifying enzymes and upregulates silencing of rDNA in response to glucose starvation. got7fsn_ti energy dependent nucleolar silencing complex dph 2016-07-09T10:12:30Z cellular_component owl:Class
GO:0031492 biolink:NamedThing nucleosomal DNA binding Binding to the DNA portion of a nucleosome. got7fsn_ti molecular_function owl:Class
GO:0010793 biolink:NamedThing regulation of mRNA export from nucleus Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm. got7fsn_ti biological_process owl:Class
GO:0021831 biolink:NamedThing embryonic olfactory bulb interneuron precursor migration The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb. got7fsn_ti biological_process owl:Class
GO:0021891 biolink:NamedThing olfactory bulb interneuron development The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0042692 biolink:NamedThing muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a muscle cell. got7fsn_ti myogenesis biological_process owl:Class
GO:0000965 biolink:NamedThing mitochondrial RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion. got7fsn_ti mitochondrial RNA 3' end processing biological_process owl:Class
GO:0001556 biolink:NamedThing oocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. got7fsn_ti Wikipedia:Oocyte_maturation biological_process owl:Class
GO:0048599 biolink:NamedThing oocyte development The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0030965 biolink:NamedThing plasma membrane electron transport, NADH to quinone The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase. got7fsn_ti biological_process owl:Class
GO:0042774 biolink:NamedThing plasma membrane ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0021978 biolink:NamedThing telencephalon regionalization The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops. got7fsn_ti biological_process owl:Class
GO:0021871 biolink:NamedThing forebrain regionalization The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops. got7fsn_ti biological_process owl:Class
GO:0021691 biolink:NamedThing cerebellar Purkinje cell layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. got7fsn_ti biological_process owl:Class
GO:0004057 biolink:NamedThing arginyltransferase activity Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein. got7fsn_ti arginyl-tRNA-protein transferase activity|arginyl-transfer ribonucleate-protein transferase activity|L-arginyl-tRNA:protein arginyltransferase activity|arginine transferase activity|arginyl-tRNA protein transferase activity|arginyl-transfer ribonucleate-protein aminoacyltransferase activity|arginyl-tRNA--protein transferase activity GO:0042172 RHEA:10208|MetaCyc:ARGINYLTRANSFERASE-RXN|EC:2.3.2.8 molecular_function owl:Class
GO:1990230 biolink:NamedThing iron-sulfur cluster transfer complex A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor). got7fsn_ti Fe-S cluster transfer complex|IscA complex|SufA complex|SufA dimer bhm 2013-11-12T09:17:40Z cellular_component owl:Class
GO:0086033 biolink:NamedThing G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate. got7fsn_ti muscarinic acetylcholine receptor signaling pathway involved in negative regulation of heart rate|M2 receptor signalling pathway involved in negative regulation of heart rate|G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate|muscarinic receptor signalling pathway involved in negative regulation of heart rate tb 2011-11-11T03:11:58Z biological_process owl:Class
GO:0003063 biolink:NamedThing negative regulation of heart rate by acetylcholine The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction. got7fsn_ti negative regulation of heart contraction rate by acetylcholine biological_process owl:Class
GO:0032060 biolink:NamedThing bleb assembly The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. got7fsn_ti plasma membrane blebbing|membrane blebbing|blebbing|cell blebbing|plasma membrane bleb assembly biological_process owl:Class
GO:0020026 biolink:NamedThing merozoite dense granule Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell. got7fsn_ti dense body cellular_component owl:Class
NCBITaxon:5794 biolink:NamedThing got7fsn_ti owl:Class
NCBITaxon:7742 biolink:NamedThing got7fsn_ti owl:Class
GO:0048735 biolink:NamedThing haltere morphogenesis The process in which the anatomical structures of a haltere are generated and organized. got7fsn_ti biological_process owl:Class
GO:0007482 biolink:NamedThing haltere development The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings. got7fsn_ti biological_process owl:Class
GO:0042716 biolink:NamedThing plasma membrane-derived chromatophore A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria. got7fsn_ti chromatophore vesicle Note that this structure is distinct from the chromoplast of plants, which is also sometimes called a chromatophore; it also should not be confused with the specialized pigment-producing cells known as chromatophores, found in fish and amphibian skin. cellular_component owl:Class
GO:0042693 biolink:NamedThing muscle cell fate commitment The process in which the cellular identity of muscle cells is acquired and determined. got7fsn_ti biological_process owl:Class
GO:0009546 biolink:NamedThing plasmodesmatal cytoplasmic sleeve The space between the plasma membrane and the desmotubule of a plasmodesma. got7fsn_ti plasmodesmatal cytoplasmic annulus cellular_component owl:Class
GO:0035865 biolink:NamedThing cellular response to potassium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. got7fsn_ti cellular response to K+ ion|cellular response to potassium bf 2011-05-25T02:59:11Z biological_process owl:Class
GO:1990613 biolink:NamedThing mitochondrial membrane fusion The joining of two lipid bilayers that surround the mitochondria. got7fsn_ti vw 2015-01-21T06:58:18Z biological_process owl:Class
GO:0061701 biolink:NamedThing bacterial outer membrane vesicle A spherical, bilayered proteolipid vesicle released from gram-negative bacterial outer membranes. got7fsn_ti dph 2015-05-07T13:53:47Z cellular_component owl:Class
GO:0090552 biolink:NamedThing unicellular trichome apex A cell projection part that is the apical most portion of a unicellular trichome. got7fsn_ti tb 2013-04-25T11:56:56Z cellular_component owl:Class
GO:0086058 biolink:NamedThing voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti dph 2011-11-17T12:35:02Z molecular_function owl:Class
GO:0086047 biolink:NamedThing membrane depolarization during Purkinje myocyte cell action potential The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti dph 2011-11-16T10:54:47Z biological_process owl:Class
GO:0020011 biolink:NamedThing apicoplast The plastid organelle found in apicomplexans. got7fsn_ti Wikipedia:Apicoplast cellular_component owl:Class
GO:0061228 biolink:NamedThing mesonephric nephron morphogenesis The process in which the anatomical structures of the mesonephric nephron are generated and organized. A mesonephric nephron is the functional unit of the mesonephros. got7fsn_ti dph 2010-08-19T02:26:24Z biological_process owl:Class
GO:0044857 biolink:NamedThing plasma membrane raft organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts. got7fsn_ti jl 2014-07-23T16:20:07Z biological_process owl:Class
GO:0030997 biolink:NamedThing regulation of centriole-centriole cohesion Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker. got7fsn_ti biological_process owl:Class
GO:0007098 biolink:NamedThing centrosome cycle The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle. got7fsn_ti centrosome organization and biogenesis|centrosome organisation|centrosome organization GO:0051297 biological_process owl:Class
GO:0071023 biolink:NamedThing trans spliceosomal complex A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates. got7fsn_ti mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0045170 biolink:NamedThing spectrosome A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome. got7fsn_ti cellular_component owl:Class
GO:0060171 biolink:NamedThing stereocilium membrane The portion of the plasma membrane surrounding a stereocilium. got7fsn_ti cellular_component owl:Class
GO:0048942 biolink:NamedThing posterior lateral line nerve glial cell morphogenesis involved in differentiation The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0022405 biolink:NamedThing hair cycle process A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. got7fsn_ti biological_process owl:Class
GO:0042633 biolink:NamedThing hair cycle The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body. got7fsn_ti biological_process owl:Class
GO:0015148 biolink:NamedThing D-xylose transmembrane transporter activity Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. got7fsn_ti molecular_function owl:Class
GO:0015753 biolink:NamedThing D-xylose transmembrane transport The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides. got7fsn_ti D-xylose transport biological_process owl:Class
GO:0031069 biolink:NamedThing hair follicle morphogenesis The process in which the anatomical structures of the hair follicle are generated and organized. got7fsn_ti biological_process owl:Class
GO:0048730 biolink:NamedThing epidermis morphogenesis The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. got7fsn_ti hypodermis morphogenesis biological_process owl:Class
GO:0060165 biolink:NamedThing regulation of timing of subpallium neuron differentiation The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon. got7fsn_ti biological_process owl:Class
GO:1904438 biolink:NamedThing regulation of iron ion import across plasma membrane Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane. got7fsn_ti regulation of ferrous iron import across plasma membrane|regulation of ferrous ion import into cell|regulation of ferrous iron import into cell rl 2015-03-04T14:37:36Z GO:1903989 biological_process owl:Class
GO:0062079 biolink:NamedThing ATG2-ATG18 complex A protein complex essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. Composed of ATG2 and ATG18 in Saccharomyces cerevisiae. got7fsn_ti dph 2018-10-12T13:47:25Z cellular_component owl:Class
GO:0006821 biolink:NamedThing chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0043108 biolink:NamedThing pilus retraction The process of withdrawing a pilus back into a cell. got7fsn_ti biological_process owl:Class
GO:0042884 biolink:NamedThing microcin transport The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0034662 biolink:NamedThing CFTR-NHERF-ezrin complex A protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity. got7fsn_ti cellular_component owl:Class
GO:0042662 biolink:NamedThing negative regulation of mesodermal cell fate specification Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification. got7fsn_ti inhibition of mesodermal cell fate specification|suppression of mesodermal cell fate|downregulation of mesodermal cell fate specification|down-regulation of mesodermal cell fate specification|down regulation of mesodermal cell fate specification biological_process owl:Class
GO:0043592 biolink:NamedThing exosporium The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid. got7fsn_ti exospore|perispore|epispore cellular_component owl:Class
GO:1990060 biolink:NamedThing maltose transport complex Protein complex facilitating ATP-dependent maltose transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic maltose-binding protein (MBP), two integral membrane proteins, MalF and MalG, and two copies of the cytoplasmic ATP-binding cassette MalK. got7fsn_ti maltose ABC transporter complex|maltose ATP-binding cassette transporter complex jl 2013-03-13T13:52:48Z cellular_component owl:Class
GO:0042790 biolink:NamedThing nucleolar large rRNA transcription by RNA polymerase I The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I. got7fsn_ti transcription of nucleolar large rRNA by RNA polymerase I|transcription of nuclear large rRNA transcript from RNA polymerase I promoter|transcription of nuclear rRNA large Pol I transcript https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0070380 biolink:NamedThing high mobility group box 1 receptor activity Combining with high mobility group box 1 (HMBGB1) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti HMGB1 receptor activity molecular_function owl:Class
GO:1900262 biolink:NamedThing regulation of DNA-directed DNA polymerase activity Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity. got7fsn_ti regulation of lambda DNA polymerase activity|regulation of DNA duplicase activity|regulation of sequenase|regulation of kappa DNA polymerase activity|regulation of DNA nucleotidyltransferase (DNA-directed) activity|regulation of DNA polymerase II|regulation of DNA replicase activity|regulation of sigma DNA polymerase activity|regulation of beta DNA polymerase activity|regulation of Klenow fragment|regulation of eta DNA polymerase activity|regulation of zeta DNA polymerase activity|regulation of DNA-dependent DNA polymerase activity|regulation of delta DNA polymerase activity|regulation of theta DNA polymerase activity|regulation of DNA polymerase gamma|regulation of DNA polymerase alpha|regulation of Taq DNA polymerase|regulation of deoxyribonucleic duplicase activity|regulation of deoxyribonucleic polymerase I|regulation of DNA polymerase V activity|regulation of mu DNA polymerase activity|regulation of deoxyribonucleic acid duplicase activity|regulation of iota DNA polymerase activity|regulation of nu DNA polymerase activity|regulation of duplicase|regulation of epsilon DNA polymerase activity|regulation of DNA polymerase beta|regulation of Taq Pol I|regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|regulation of alpha DNA polymerase activity|regulation of DNA polymerase III|regulation of gamma DNA-directed DNA polymerase activity|regulation of Tca DNA polymerase|regulation of DNA polymerase I tb 2012-04-03T11:07:08Z biological_process owl:Class
GO:0046628 biolink:NamedThing positive regulation of insulin receptor signaling pathway Any process that increases the frequency, rate or extent of insulin receptor signaling. got7fsn_ti up-regulation of insulin receptor signaling pathway|stimulation of insulin receptor signaling pathway|activation of insulin receptor signaling pathway|positive regulation of insulin receptor signalling pathway|up regulation of insulin receptor signaling pathway|upregulation of insulin receptor signaling pathway biological_process owl:Class
GO:0030428 biolink:NamedThing cell septum A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. got7fsn_ti septum|cross wall cellular_component owl:Class
GO:1990100 biolink:NamedThing DnaB-DnaC complex A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC). got7fsn_ti helicase-loading complex|DnaB6-DnaC3 complex|DnaB6-DnaC6 complex DnaB and DnaC may be present in different ratios in different forms of the DnaB-DnaC complex, including a DnaB6-DnaC3 complex active at the oriC, and a DnaB6-DnaC6 complex. bhm 2013-05-14T12:02:22Z cellular_component owl:Class
GO:0034257 biolink:NamedThing nicotinamide riboside transmembrane transporter activity Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other. got7fsn_ti RHEA:33163 molecular_function owl:Class
GO:0034258 biolink:NamedThing nicotinamide riboside transport The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1904886 biolink:NamedThing beta-catenin destruction complex disassembly The disaggregation of a beta-catenin destruction complex into its constituent components. got7fsn_ti 23S APC complex disassembly|dissociation of beta-catenin degradation complex|BDC disassembly|beta-catenin degradation complex disassembly|APC-Axin-1-beta-catenin complex disassembly|Axin-APC-beta-catenin-GSK3B complex disassembly bf 2016-01-05T11:41:02Z biological_process owl:Class
GO:0060070 biolink:NamedThing canonical Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. got7fsn_ti Wnt receptor signaling pathway through beta-catenin|canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway via beta-catenin|canonical Wnt-activated signaling pathway|Wnt receptor signalling pathway through beta-catenin|frizzled-1 receptor signaling pathway biological_process owl:Class
GO:0001986 biolink:NamedThing negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure. got7fsn_ti decreased strength of cardiac contraction during baroreceptor response to increased blood pressure|decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure biological_process owl:Class
GO:0048357 biolink:NamedThing pedicel mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the flower stem. got7fsn_ti pedicel mucilage formation|pedicel mucilage anabolism|pedicel mucilage synthesis|pedicel mucilage biosynthesis biological_process owl:Class
GO:0048362 biolink:NamedThing pedicel mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the flower stem. got7fsn_ti pedicel mucilage metabolism biological_process owl:Class
GO:0015633 biolink:NamedThing ABC-type zinc transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in). got7fsn_ti zinc transporting ATPase activity|ATP-dependent zinc transmembrane transporter activity|zinc-transporting ATPase activity|ATPase-coupled zinc transmembrane transporter activity|zinc porter activity RHEA:29795|EC:7.2.2.20 molecular_function owl:Class
GO:0071577 biolink:NamedThing zinc ion transmembrane transport A process in which a zinc II ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti zinc transmembrane transport|zinc II ion transmembrane transport|zinc ion membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-01-28T02:17:12Z biological_process owl:Class
GO:0015230 biolink:NamedThing FAD transmembrane transporter activity Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. got7fsn_ti flavin adenine dinucleotide transmembrane transporter activity|flavin-adenine dinucleotide transmembrane transporter activity|FAD carrier activity|FAD transporter activity|flavin adenine dinucleotide carrier activity|flavin-adenine dinucleotide carrier activity GO:0005472 molecular_function owl:Class
GO:0035350 biolink:NamedThing FAD transmembrane transport The process in which flavin-adenine dinucleotide (FAD) is transported across a membrane. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form. got7fsn_ti FAD membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-03-04T03:45:11Z biological_process owl:Class
GO:0045284 biolink:NamedThing plasma membrane fumarate reductase complex A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species. got7fsn_ti fumarate reductase complex See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. cellular_component owl:Class
GO:0045274 biolink:NamedThing plasma membrane respiratory chain complex II A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species. got7fsn_ti respiratory chain complex II cellular_component owl:Class
GO:0050322 biolink:NamedThing taurine-2-oxoglutarate transaminase activity Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate. got7fsn_ti taurine aminotransferase activity|taurine--alpha-ketoglutarate aminotransferase activity|taurine transaminase activity|taurine--glutamate transaminase activity|taurine:2-oxoglutarate aminotransferase activity EC:2.6.1.55|MetaCyc:RXN-2301|RHEA:16353 molecular_function owl:Class
GO:0070743 biolink:NamedThing interleukin-23 complex A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. got7fsn_ti p40|IL-23 complex|IL23A|p19|IL12B Note that this heterodimeric cytokine utilizes the same beta subunit as IL-12. mah 2009-06-23T01:06:02Z cellular_component owl:Class
GO:0009908 biolink:NamedThing flower development The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem. got7fsn_ti GO:0048409 biological_process owl:Class
GO:0061458 biolink:NamedThing reproductive system development The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. got7fsn_ti dph 2012-08-22T17:47:53Z biological_process owl:Class
GO:0060317 biolink:NamedThing cardiac epithelial to mesenchymal transition A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. got7fsn_ti heart epithelial to mesenchymal transition biological_process owl:Class
GO:0031504 biolink:NamedThing peptidoglycan-based cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall. got7fsn_ti peptidoglycan-based cell wall organisation|peptidoglycan-based cell wall organization and biogenesis biological_process owl:Class
GO:0035077 biolink:NamedThing ecdysone-mediated polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation. got7fsn_ti biological_process owl:Class
GO:0071390 biolink:NamedThing cellular response to ecdysone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus. got7fsn_ti mah 2009-12-11T04:03:57Z biological_process owl:Class
GO:0098751 biolink:NamedThing bone cell development The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti Not to be used for manual annotation. Please choose a more specific cell development term or if not possible, bone or bone tissue development. biological_process owl:Class
GO:0060348 biolink:NamedThing bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components. got7fsn_ti biological_process owl:Class
GO:0036484 biolink:NamedThing trunk neural crest cell migration The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo. got7fsn_ti trunk NCC migration bf 2014-08-26T15:27:44Z biological_process owl:Class
GO:0035290 biolink:NamedThing trunk segmentation Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. got7fsn_ti biological_process owl:Class
GO:0120293 biolink:NamedThing dynein axonemal particle An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm. got7fsn_ti DynAP https://github.com/geneontology/go-ontology/issues/20687 krc 2021-01-19T01:47:17Z cellular_component owl:Class
GO:0031092 biolink:NamedThing platelet alpha granule membrane The lipid bilayer surrounding the platelet alpha granule. got7fsn_ti platelet alpha-granule membrane cellular_component owl:Class
GO:0034342 biolink:NamedThing response to type III interferon Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type III interferon stimulus. Interferon lambda is the only member of the type III interferon found so far. got7fsn_ti response to interferon-lambda|response to type III IFN biological_process owl:Class
GO:1901726 biolink:NamedThing negative regulation of histone deacetylase activity Any process that stops, prevents or reduces the frequency, rate or extent of histone deacetylase activity. got7fsn_ti down-regulation of histone deacetylase activity|downregulation of histone deacetylase activity|inhibition of histone deacetylase activity|down regulation of histone deacetylase activity rl 2013-01-07T09:14:17Z biological_process owl:Class
GO:0043625 biolink:NamedThing delta DNA polymerase complex A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair. got7fsn_ti delta-DNA polymerase complex GO:0005659 cellular_component owl:Class
GO:0071365 biolink:NamedThing cellular response to auxin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus. got7fsn_ti mah 2009-12-11T03:10:22Z biological_process owl:Class
GO:0017128 biolink:NamedThing phospholipid scramblase activity Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. got7fsn_ti Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). molecular_function owl:Class
GO:0017121 biolink:NamedThing plasma membrane phospholipid scrambling The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). got7fsn_ti PL scrambling|phospholipid scrambling Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'. biological_process owl:Class
GO:0070153 biolink:NamedThing mitochondrial leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA in a mitochondrion, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0090615 biolink:NamedThing mitochondrial mRNA processing Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs. got7fsn_ti tb 2014-10-24T12:43:27Z biological_process owl:Class
GO:0007083 biolink:NamedThing mitotic chromosome decondensation The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells. got7fsn_ti biological_process owl:Class
GO:0000070 biolink:NamedThing mitotic sister chromatid segregation The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. got7fsn_ti mitotic sister-chromatid adhesion release|mitotic chromosome segregation GO:0016359 biological_process owl:Class
GO:0061838 biolink:NamedThing CENP-T-W-S-X complex A histone-variant containing protein complex which forms a centromere specific nucleosomal structure, involved in centromeric chromatin organization. got7fsn_ti cellular_component owl:Class
GO:0000775 biolink:NamedThing chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. got7fsn_ti chromosome, pericentric region|centromere|centromere complex|chromosome, centric region Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. GO:0097521 SO:0000577 cellular_component owl:Class
GO:0009654 biolink:NamedThing photosystem II oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). got7fsn_ti oxygen evolving complex|OEC (PSII) complex Wikipedia:Oxygen_evolving_complex cellular_component owl:Class
GO:0044512 biolink:NamedThing envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism. got7fsn_ti jl 2012-02-26T10:20:19Z biological_process owl:Class
GO:0044506 biolink:NamedThing modulation of glucagon-like peptide receptor 1 activity in other organism The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism. got7fsn_ti regulation of glucagon-like peptide receptor activity in other organism jl 2012-02-23T04:29:14Z biological_process owl:Class
GO:0048480 biolink:NamedThing stigma development The process whose specific outcome is the progression of the stigma over time, from its formation to the mature structure. The stigma is the pollen-receptive surface of a carpel or group of fused carpels, usually sticky. got7fsn_ti biological_process owl:Class
GO:0003235 biolink:NamedThing sinus venosus development The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. got7fsn_ti dph 2009-10-13T11:12:34Z biological_process owl:Class
GO:1990661 biolink:NamedThing S100A8 complex A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4). got7fsn_ti S100A8 homodimer An example of this is S100A8 in human (UniProt symbol P27005) in PMID:25417112 (inferred from direct assay). bhm 2015-02-25T15:33:32Z cellular_component owl:Class
GO:0000910 biolink:NamedThing cytokinesis The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells. got7fsn_ti cell cycle cytokinesis|cytokinesis involved in cell cycle Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other. GO:0016288|GO:0007104|GO:0033205 Wikipedia:Cytokinesis biological_process owl:Class
PR:000000001 biolink:NamedThing got7fsn_ti owl:Class
GO:0005786 biolink:NamedThing signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. got7fsn_ti signal sequence receptor complex|SRP GO:0005855 Wikipedia:Signal_recognition_particle cellular_component owl:Class
GO:0097399 biolink:NamedThing interleukin-32-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-32 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-32-mediated signaling pathway|interleukin-32-mediated signalling pathway|IL-32-mediated signalling pathway pr 2012-10-23T13:27:22Z biological_process owl:Class
GO:0036349 biolink:NamedThing galactose-specific flocculation The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other. got7fsn_ti cell-cell adhesion involved in galactose-specific flocculation bf 2012-09-19T10:56:16Z GO:0098611 biological_process owl:Class
GO:0005534 biolink:NamedThing galactose binding Binding to aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides. got7fsn_ti galactose binding lectin molecular_function owl:Class
GO:0052607 biolink:NamedThing 7-hydroxy-chlorophyllide a oxygenase activity Catalysis of the reaction: 7-hydroxychlorophyllide a + NADPH + O2 + H+ = chlorophyllide b + NADP+ + 2 H2O. got7fsn_ti CAO activity|chlorophyll-b synthase activity|chlorophyll b synthetase activity|7-hydroxychlorophyllide-a oxygenase activity|7-hydroxychlorophyllide a:oxygen 7-oxidoreductase activity KEGG_REACTION:R08204|MetaCyc:RXN-7677|RHEA:22136 molecular_function owl:Class
GO:0010277 biolink:NamedThing chlorophyllide a oxygenase [overall] activity Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. got7fsn_ti CAO activity|chlorophyll a oxygenation activity|chlorophyllide-a oxygenation activity|chlorophyll-b synthesis activity|chlorophyllide a:oxygen 7-oxidoreduction activity|chlorophyll b synthesis activity This is a process composed of two reactions represented by the terms 'GO:0052606 : chlorophyllide a oxygenase activity' and 'GO:0052607 : 7-hydroxy-chlorophyllide a oxygenase activity'. GO:0046407 EC:1.14.13.122|RHEA:30359 molecular_function owl:Class
GO:1901046 biolink:NamedThing positive regulation of oviposition Any process that activates or increases the frequency, rate or extent of oviposition. got7fsn_ti positive regulation of egg-laying|up regulation of oviposition|up-regulation of egg-laying|activation of egg laying|upregulation of oviposition|activation of egg-laying|positive regulation of egg laying|activation of oviposition|up-regulation of oviposition|up-regulation of egg laying|upregulation of egg laying|up regulation of egg laying|up regulation of egg-laying|upregulation of egg-laying kmv 2012-06-27T06:20:20Z biological_process owl:Class
GO:0004862 biolink:NamedThing cAMP-dependent protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase. got7fsn_ti Reactome:R-HSA-180073 molecular_function owl:Class
GO:0060415 biolink:NamedThing muscle tissue morphogenesis The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. got7fsn_ti biological_process owl:Class
GO:0048644 biolink:NamedThing muscle organ morphogenesis The process in which the anatomical structures of muscle are generated and organized. got7fsn_ti biological_process owl:Class
GO:1990905 biolink:NamedThing dinoflagellate peduncle A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy). got7fsn_ti The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. pr 2015-11-22T10:22:46Z cellular_component owl:Class
GO:0043315 biolink:NamedThing positive regulation of neutrophil degranulation Any process that activates or increases the frequency, rate or extent of neutrophil degranulation. got7fsn_ti activation of neutrophil degranulation|upregulation of neutrophil degranulation|positive regulation of neutrophil granule exocytosis|stimulation of neutrophil degranulation|up-regulation of neutrophil degranulation|up regulation of neutrophil degranulation biological_process owl:Class
GO:0005884 biolink:NamedThing actin filament A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane. got7fsn_ti microfilament FMA:63850|NIF_Subcellular:sao1588493326|Wikipedia:Actin cellular_component owl:Class
GO:0061822 biolink:NamedThing ciliary cap An intracellular compartmentalized cilium structure found in insect spermatids which is bounded by a membrane derived from the invagination of the cell membrane that remains associated with the primary cilium as it is internalized. The ciliary cap is maintained at the end of the axoneme distal to the centriole and is separated from the cytosolic axoneme/cytoplasm by a putative transition zone, which may extend into the ciliary cap, and include a structure at the base of the ciliary cap termed the ring centriole. got7fsn_ti spermatid ciliary cap dph 2017-01-14T14:14:11Z cellular_component owl:Class
GO:0034510 biolink:NamedThing centromere separation The cell cycle process in which centromeres are physically detached from each other during chromosome separation. got7fsn_ti biological_process owl:Class
GO:0098813 biolink:NamedThing nuclear chromosome segregation The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. got7fsn_ti biological_process owl:Class
GO:0044638 biolink:NamedThing envenomation resulting in positive regulation of complement activation, classical pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism. got7fsn_ti jl 2012-07-05T04:51:36Z biological_process owl:Class
GO:0044628 biolink:NamedThing positive regulation of complement activation, classical pathway in other organism Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism. got7fsn_ti jl 2012-07-05T01:00:10Z biological_process owl:Class
GO:0000966 biolink:NamedThing RNA 5'-end processing Any process involved in forming the mature 5' end of an RNA molecule. got7fsn_ti RNA 5' end processing biological_process owl:Class
GO:0052884 biolink:NamedThing all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate. got7fsn_ti retinol isomerase activity|all-trans-retinol isomerase:hydrolase activity|all-trans-retinyl-palmitate hydrolase activity|retinoid isomerohydrolase activity RHEA:31775|Reactome:R-HSA-2453833|EC:3.1.1.64 molecular_function owl:Class
GO:0042572 biolink:NamedThing retinol metabolic process The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. got7fsn_ti vitamin A1 metabolic process|vitamin A1 alcohol metabolism|retinol metabolism|vitamin A1 metabolism|vitamin A1 alcohol metabolic process Wikipedia:Retinol biological_process owl:Class
GO:0000502 biolink:NamedThing proteasome complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. got7fsn_ti 26S proteasome|proteasome cellular_component owl:Class
GO:0015412 biolink:NamedThing ABC-type molybdate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in). got7fsn_ti molybdate transmembrane-transporting ATPase activity|molybdate transporting ATPase activity|ATPase-coupled molybdate transmembrane transporter activity|molybdate ABC transporter|molybdate porter activity|molybdate-transporting ATPase activity EC:7.3.2.5|MetaCyc:3.6.3.29-RXN|RHEA:22020 molecular_function owl:Class
GO:0015689 biolink:NamedThing molybdate ion transport The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. got7fsn_ti biological_process owl:Class
GO:0030297 biolink:NamedThing transmembrane receptor protein tyrosine kinase activator activity Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase. got7fsn_ti molecular_function owl:Class
GO:0007171 biolink:NamedThing activation of transmembrane receptor protein tyrosine kinase activity Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity. got7fsn_ti transmembrane receptor protein tyrosine kinase dimerization|transmembrane receptor protein tyrosine kinase activation biological_process owl:Class
GO:0045124 biolink:NamedThing regulation of bone resorption Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). got7fsn_ti biological_process owl:Class
GO:0034519 biolink:NamedThing cytoplasmic RNA cap binding complex A protein complex found in the cytoplasm that binds the 5' cap structure of an mRNA, and typically consists of the cap-binding protein eIF4E, the adaptor protein eIF4G, and a multi-factor complex comprising eIF1, eIF2, eIF3 and eIF5. This complex mediates recruitment of the 40S subunit to mRNA. got7fsn_ti cellular_component owl:Class
GO:0042016 biolink:NamedThing interleukin-20 receptor activity Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-20 receptor activity|IL-20R molecular_function owl:Class
GO:1990231 biolink:NamedThing STING complex A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. got7fsn_ti stimulator of interferon genes complex bhm 2013-11-12T10:58:34Z cellular_component owl:Class
GO:0061507 biolink:NamedThing 2',3'-cyclic GMP-AMP binding Binding to 2',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 2',5' and 3',5' linkages. got7fsn_ti 2',3'-cyclic GAMP binding|2',3' cyclic GAMP binding|2',5-3',5'-cyclic GMP-AMP binding|2',3'-cGAMP binding|cyclic-GMP-AMP binding|2',3' cGAMP binding|c[G(2',5')pA(3',5')p] binding https://github.com/geneontology/go-ontology/issues/21980 dph 2013-01-24T15:38:27Z GO:0098546 molecular_function owl:Class
GO:0061194 biolink:NamedThing taste bud morphogenesis The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors. got7fsn_ti dph 2010-07-27T11:01:31Z biological_process owl:Class
GO:0072589 biolink:NamedThing box H/ACA scaRNP complex A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs. got7fsn_ti nucleoplasmic box H/ACA RNP pseudouridylase complex mah 2011-02-10T02:47:17Z cellular_component owl:Class
GO:0021713 biolink:NamedThing inferior olivary nucleus development The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. got7fsn_ti inferior olive development biological_process owl:Class
GO:0051307 biolink:NamedThing meiotic chromosome separation The process in which chromosomes are physically detached from each other during meiosis. got7fsn_ti chromosome separation during meiosis|meiotic chromosome resolution biological_process owl:Class
GO:0002812 biolink:NamedThing biosynthetic process of antibacterial peptides active against Gram-negative bacteria The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria. got7fsn_ti biological_process owl:Class
GO:0050829 biolink:NamedThing defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism. got7fsn_ti defence response to Gram-negative bacterium|Gram-negative antibacterial peptide activity|defence response to Gram-negative bacteria|defense response to Gram-negative bacteria biological_process owl:Class
GO:0008198 biolink:NamedThing ferrous iron binding Binding to a ferrous iron ion, Fe(II). got7fsn_ti molecular_function owl:Class
GO:0050187 biolink:NamedThing phosphoamidase activity Catalysis of the reaction: N-phosphocreatine + H(2)O = creatine + phosphate. got7fsn_ti phosphamide hydrolase activity|creatine phosphatase activity RHEA:12977|EC:3.9.1.1|KEGG_REACTION:R01882|MetaCyc:PHOSPHOAMIDASE-RXN molecular_function owl:Class
GO:0033026 biolink:NamedThing negative regulation of mast cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process. got7fsn_ti down regulation of mast cell apoptosis|inhibition of mast cell apoptosis|negative regulation of mast cell apoptosis|down-regulation of mast cell apoptosis|downregulation of mast cell apoptosis biological_process owl:Class
GO:0070145 biolink:NamedThing mitochondrial asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA in a mitochondrion, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0098970 biolink:NamedThing postsynaptic neurotransmitter receptor diffusion trapping The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization. got7fsn_ti biological_process owl:Class
GO:0099634 biolink:NamedThing postsynaptic specialization membrane The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. got7fsn_ti cellular_component owl:Class
GO:0061029 biolink:NamedThing eyelid development in camera-type eye The progression of the eyelid in a camera-type eye from its formation to the mature state. The eyelid is a membranous cover that helps protect and lubricate the eye. got7fsn_ti dph 2010-02-09T09:36:11Z biological_process owl:Class
GO:0048527 biolink:NamedThing lateral root development The process whose specific outcome is the progression of the lateral root over time, from its formation to the mature structure. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper. got7fsn_ti biological_process owl:Class
GO:1990047 biolink:NamedThing spindle matrix A proteinaceous, nuclear-derived structure that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner during mitosis. got7fsn_ti pr 2013-02-18T08:51:47Z cellular_component owl:Class
GO:0001527 biolink:NamedThing microfibril Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins. got7fsn_ti fibrillin|extended fibrils cellular_component owl:Class
NCBITaxon:4952 biolink:NamedThing got7fsn_ti owl:Class
GO:0042063 biolink:NamedThing gliogenesis The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia. got7fsn_ti glial cell generation biological_process owl:Class
GO:0000162 biolink:NamedThing tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. got7fsn_ti tryptophan anabolism|tryptophan formation|tryptophan synthesis|tryptophan biosynthesis|aromatic amino acid family biosynthetic process, anthranilate pathway GO:0009096 MetaCyc:TRPSYN-PWY biological_process owl:Class
GO:0051875 biolink:NamedThing pigment granule localization Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti pigment granule localisation biological_process owl:Class
GO:0007417 biolink:NamedThing central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. got7fsn_ti CNS development Wikipedia:Neural_development biological_process owl:Class
GO:0042025 biolink:NamedThing host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti GO:0033649 cellular_component owl:Class
GO:0030478 biolink:NamedThing actin cap Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae. got7fsn_ti GO:0000143 cellular_component owl:Class
GO:0060681 biolink:NamedThing branch elongation involved in ureteric bud branching The growth of a branch of the ureteric bud along its axis. got7fsn_ti dph 2009-06-02T02:52:55Z biological_process owl:Class
GO:0060677 biolink:NamedThing ureteric bud elongation The developmental growth in which the ureteric bud grows along its axis beginning with the growth of the primary ureteric bud and ending when the branches of the bud have elongated. got7fsn_ti dph 2009-06-02T02:13:29Z biological_process owl:Class
GO:0071922 biolink:NamedThing regulation of cohesin loading Any process that modulates the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin. got7fsn_ti regulation of cohesin localisation to chromatin|regulation of cohesin association with chromatin|regulation of cohesin localization to chromatin mah 2010-09-28T11:13:35Z biological_process owl:Class
GO:0001845 biolink:NamedThing phagolysosome assembly The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome. got7fsn_ti late phagosome formation|late phagosome biosynthesis|phagolysosome formation biological_process owl:Class
GO:0006909 biolink:NamedThing phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. got7fsn_ti Wikipedia:Phagocytosis biological_process owl:Class
GO:0035913 biolink:NamedThing ventral aorta morphogenesis The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:24:36Z biological_process owl:Class
GO:0035908 biolink:NamedThing ventral aorta development The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:08:49Z biological_process owl:Class
GO:0021803 biolink:NamedThing extension of leading cell process to pial surface The extension of a long process to the pial surface as a cell leaves the ventricular zone. got7fsn_ti biological_process owl:Class
GO:0021802 biolink:NamedThing somal translocation The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate. got7fsn_ti perikaryal translocation of Morest biological_process owl:Class
GO:0045804 biolink:NamedThing negative regulation of eclosion Any process that stops, prevents, or reduces the frequency, rate or extent of eclosion. got7fsn_ti down-regulation of eclosion|inhibition of eclosion|downregulation of eclosion|down regulation of eclosion biological_process owl:Class
GO:0005350 biolink:NamedThing pyrimidine nucleobase transmembrane transporter activity Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. got7fsn_ti pyrimidine base transmembrane transporter activity|pyrimidine transmembrane transporter activity molecular_function owl:Class
GO:0005739 biolink:NamedThing mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. got7fsn_ti mitochondria Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) Wikipedia:Mitochondrion|NIF_Subcellular:sao1860313010 cellular_component owl:Class
NCBITaxon:9443 biolink:NamedThing got7fsn_ti owl:Class
GO:0008335 biolink:NamedThing female germline ring canal stabilization Maintenance of the structural integrity of the ring canals connecting the female germline cyst. got7fsn_ti nurse cell ring canal stabilization|ovarian ring canal stabilization biological_process owl:Class
GO:2000767 biolink:NamedThing positive regulation of cytoplasmic translation Any process that activates or increases the frequency, rate or extent of cytoplasmic translation. got7fsn_ti vw 2011-06-20T10:39:26Z biological_process owl:Class
GO:0035679 biolink:NamedThing anterior lateral line neuromast hair cell morphogenesis The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. got7fsn_ti bf 2011-02-14T11:06:54Z biological_process owl:Class
GO:0035676 biolink:NamedThing anterior lateral line neuromast hair cell development The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti bf 2011-02-14T11:03:57Z biological_process owl:Class
GO:1905283 biolink:NamedThing negative regulation of epidermal growth factor receptor signaling pathway involved in heart process Any process that stops, prevents or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process. got7fsn_ti inhibition of ERBB1 signaling pathway involved in heart process|negative regulation of EGF receptor signaling pathway involved in cardiac process|negative regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|inhibition of EGF receptor signalling pathway involved in cardiac process|downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|down regulation of epidermal growth factor receptor signalling pathway involved in heart process|inhibition of epidermal growth factor receptor signaling pathway involved in cardiac process|down-regulation of EGFR signaling pathway involved in heart process|inhibition of EGF receptor signalling pathway involved in heart process|downregulation of EGF receptor signaling pathway involved in cardiac process|inhibition of epidermal growth factor receptor signalling pathway involved in heart process|down-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|downregulation of EGFR signaling pathway involved in cardiac process|down-regulation of epidermal growth factor receptor signaling pathway involved in heart process|downregulation of ERBB1 signaling pathway involved in heart process|inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|downregulation of epidermal growth factor receptor signalling pathway involved in cardiac process|down-regulation of ERBB1 signaling pathway involved in cardiac process|downregulation of EGF receptor signalling pathway involved in heart process|down-regulation of epidermal growth factor receptor signalling pathway involved in heart process|negative regulation of EGFR signaling pathway involved in heart process|down regulation of EGFR signaling pathway involved in heart process|downregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|downregulation of EGFR signaling pathway involved in heart process|down regulation of ERBB1 signaling pathway involved in heart process|down regulation of EGF receptor signalling pathway involved in cardiac process|negative regulation of EGF receptor signalling pathway involved in cardiac process|downregulation of epidermal growth factor receptor signaling pathway involved in heart process|negative regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|downregulation of epidermal growth factor receptor signalling pathway involved in heart process|down regulation of EGF receptor signaling pathway involved in cardiac process|down regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|negative regulation of ERBB1 signaling pathway involved in heart process|down regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|inhibition of epidermal growth factor receptor signaling pathway involved in heart process|inhibition of epidermal growth factor receptor signalling pathway involved in cardiac process|inhibition of EGF receptor signaling pathway involved in heart process|down-regulation of EGF receptor signalling pathway involved in heart process|inhibition of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|down-regulation of ERBB1 signaling pathway involved in heart process|down regulation of EGFR signaling pathway involved in cardiac process|negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|down regulation of ERBB1 signaling pathway involved in cardiac process|inhibition of EGF receptor signaling pathway involved in cardiac process|negative regulation of EGF receptor signalling pathway involved in heart process|down-regulation of EGF receptor signalling pathway involved in cardiac process|inhibition of EGFR signaling pathway involved in heart process|down regulation of epidermal growth factor receptor signaling pathway involved in heart process|down-regulation of EGFR signaling pathway involved in cardiac process|downregulation of EGF receptor signaling pathway involved in heart process|down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|negative regulation of EGFR signaling pathway involved in cardiac process|down-regulation of EGF receptor signaling pathway involved in heart process|downregulation of epidermal growth factor receptor signaling pathway involved in cardiac process|down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|negative regulation of epidermal growth factor receptor signalling pathway involved in heart process|negative regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|down regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|inhibition of ERBB1 signaling pathway involved in cardiac process|downregulation of EGF receptor signalling pathway involved in cardiac process|down regulation of EGF receptor signaling pathway involved in heart process|inhibition of EGFR signaling pathway involved in cardiac process|down-regulation of EGF receptor signaling pathway involved in cardiac process|downregulation of ERBB1 signaling pathway involved in cardiac process|down regulation of EGF receptor signalling pathway involved in heart process|down-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|down-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|negative regulation of ERBB1 signaling pathway involved in cardiac process|negative regulation of EGF receptor signaling pathway involved in heart process bc 2016-06-20T14:40:49Z biological_process owl:Class
GO:0008917 biolink:NamedThing lipopolysaccharide N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide. got7fsn_ti uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity|LPS N-acetylglucosaminyltransferase activity|UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity MetaCyc:2.4.1.56-RXN|EC:2.4.1.56 molecular_function owl:Class
GO:0048355 biolink:NamedThing root cap mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the root cap; mucilage is normally synthesized during root growth. got7fsn_ti root cap mucilage formation|root cap mucilage synthesis|root cap mucilage biosynthesis|root cap mucilage anabolism biological_process owl:Class
GO:0048360 biolink:NamedThing root cap mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth. got7fsn_ti root cap mucilage metabolism biological_process owl:Class
GO:0090220 biolink:NamedThing chromosome localization to nuclear envelope involved in homologous chromosome segregation The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis. got7fsn_ti chromosome localisation to nuclear envelope involved in homologous chromosome segregation tb 2010-01-13T10:20:33Z biological_process owl:Class
GO:0061830 biolink:NamedThing concave side of sperm head The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species. got7fsn_ti cellular_component owl:Class
GO:0072322 biolink:NamedThing protein transport across periplasmic space The directed movement of proteins from the plasma membrane across the periplasmic space to the outer membrane or cell wall. got7fsn_ti chaperone-mediated protein transport across periplasmic space https://github.com/geneontology/go-ontology/issues/15917 mah 2010-10-28T04:24:59Z GO:0072323 biological_process owl:Class
GO:0140597 biolink:NamedThing protein carrier activity Binding to and carrying a protein between two different cellular locations by moving along with the target protein. got7fsn_ti protein chaperone|protein carrier chaperone https://github.com/geneontology/go-ontology/issues/15917 pg 2021-02-10T06:16:16Z molecular_function owl:Class
GO:0000795 biolink:NamedThing synaptonemal complex A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element. got7fsn_ti GO:0005716 Wikipedia:Synaptonemal_complex cellular_component owl:Class
GO:0021765 biolink:NamedThing cingulate gyrus development The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum. got7fsn_ti biological_process owl:Class
GO:0021761 biolink:NamedThing limbic system development The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory. got7fsn_ti biological_process owl:Class
GO:0042713 biolink:NamedThing sperm ejaculation The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract. got7fsn_ti biological_process owl:Class
GO:0061844 biolink:NamedThing antimicrobial humoral immune response mediated by antimicrobial peptide An immune response against microbes mediated by anti-microbial peptides in body fluid. got7fsn_ti antimicrobial peptide-mediated antimicrobial humoral response|peptide-mediated antimicrobial humoral response biological_process owl:Class
GO:0043845 biolink:NamedThing DNA polymerase III, proofreading complex A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity. got7fsn_ti DNA polymerase III, proofreading subcomplex|DNA polymerase III, proof-reading complex|DNA polymerase III, proof-reading subcomplex cellular_component owl:Class
GO:0044776 biolink:NamedThing DNA polymerase III, core complex The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities. got7fsn_ti jl 2013-03-13T14:09:38Z cellular_component owl:Class
GO:0048816 biolink:NamedThing ocellus morphogenesis The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects. got7fsn_ti biological_process owl:Class
GO:0007455 biolink:NamedThing eye-antennal disc morphogenesis The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps. got7fsn_ti eye-antennal disc metamorphosis biological_process owl:Class
GO:0003406 biolink:NamedThing retinal pigment epithelium development The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells. got7fsn_ti RPE development dph 2009-12-21T02:04:27Z biological_process owl:Class
GO:0002634 biolink:NamedThing regulation of germinal center formation Any process that modulates the frequency, rate, or extent of germinal center formation. got7fsn_ti biological_process owl:Class
GO:0060900 biolink:NamedThing embryonic camera-type eye formation The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape. got7fsn_ti dph 2009-08-13T02:26:54Z biological_process owl:Class
GO:0032778 biolink:NamedThing P-type cobalt transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in). got7fsn_ti cobalt transporting ATPase activity|ATPase-coupled cobalt transmembrane transporter activity|ATP-dependent cobalt transmembrane transporter activity|cobalt-transporting ATPase activity|cobalt porter activity GO:0015632 RHEA:32779 molecular_function owl:Class
GO:0006824 biolink:NamedThing cobalt ion transport The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti cobalt transport biological_process owl:Class
GO:1905938 biolink:NamedThing positive regulation of germ cell proliferation Any process that activates or increases the frequency, rate or extent of germ cell proliferation. got7fsn_ti activation of germ cell proliferation|up-regulation of germ cell proliferation|upregulation of germ cell proliferation|up regulation of germ cell proliferation hbye 2017-02-09T14:51:51Z biological_process owl:Class
GO:0004921 biolink:NamedThing interleukin-11 receptor activity Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-11R|gp130|IL-11 receptor activity molecular_function owl:Class
GO:0038154 biolink:NamedThing interleukin-11-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-11 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-11-mediated signaling pathway|interleukin-11-mediated signalling pathway bf 2012-05-11T11:48:37Z biological_process owl:Class
GO:0090394 biolink:NamedThing negative regulation of excitatory postsynaptic potential Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. got7fsn_ti reduction of excitatory postsynaptic membrane potential|negative regulation of EPSP|negative regulation of excitatory post-synaptic membrane potential tb 2010-12-15T01:43:12Z biological_process owl:Class
GO:0006413 biolink:NamedThing translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. got7fsn_ti biopolymerisation|biopolymerization|protein synthesis initiation|translation initiation GO:0006454|GO:0006440 biological_process owl:Class
GO:0008384 biolink:NamedThing IkappaB kinase activity Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. got7fsn_ti IKK|inhibitor of NFkappaB kinase activity|inhibitor of NF-kappaB kinase activity|TBK1|IKK-1|ATP:IkappaB protein phosphotransferase activity|STK12|ikappaB kinase activity|IKBKA|IKBKB|CHUK|TANK-binding kinase 1 activity|IKK-2 Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. EC:2.7.11.10|Reactome:R-HSA-5684275|Reactome:R-HSA-5684267|MetaCyc:2.7.11.10-RXN|RHEA:19073 molecular_function owl:Class
GO:0007252 biolink:NamedThing I-kappaB phosphorylation The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. got7fsn_ti IKB phosphorylation|inhibitor of NF-kappaB phosphorylation|IkappaB phosphorylation|inhibitor of kappaB phosphorylation biological_process owl:Class
GO:0036241 biolink:NamedThing glutamate catabolic process to 4-hydroxybutyrate The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate. got7fsn_ti glutamate degradation to 4-hydroxybutyrate In the catabolism of glutamate in mammals, succinate semialdehyde is converted to succinate (see GO:0006540). Plants can utilize an alternative route, converting succinic semialdehyde to 4-hydroxybutyrate using gamma-hydroxybutyrate dehydrogenase. bf 2012-05-23T02:17:05Z biological_process owl:Class
GO:0047577 biolink:NamedThing 4-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: 4-hydroxybutanoate + NAD(+) = H(+) + NADH + succinate semialdehyde. got7fsn_ti gamma-hydroxybutyrate dehydrogenase activity|4-hydroxybutanoate:NAD+ oxidoreductase activity EC:1.1.1.61|MetaCyc:4-HYDROXYBUTYRATE-DEHYDROGENASE-RXN|KEGG_REACTION:R01644|RHEA:23948 molecular_function owl:Class
GO:0010159 biolink:NamedThing specification of animal organ position The regionalization process in which information that determines the correct position at which animal organ primordia are formed is generated and perceived resulting in correct positioning of the new animal organ. got7fsn_ti biological_process owl:Class
GO:0035857 biolink:NamedThing eosinophil fate specification The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. got7fsn_ti eosinophil cell fate specification bf 2011-05-17T10:42:54Z biological_process owl:Class
GO:0035854 biolink:NamedThing eosinophil fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. got7fsn_ti eosinophil cell fate commitment bf 2011-05-13T01:23:28Z biological_process owl:Class
GO:2000033 biolink:NamedThing regulation of seed dormancy process Any process that modulates the frequency, rate or extent of seed dormancy process. got7fsn_ti regulation of seed dormancy tb 2010-08-05T11:33:13Z biological_process owl:Class
GO:0044663 biolink:NamedThing establishment or maintenance of cell type involved in phenotypic switching A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. got7fsn_ti jl 2012-08-07T14:30:07Z biological_process owl:Class
GO:0036166 biolink:NamedThing phenotypic switching A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues. got7fsn_ti phenotypic dimorphism Mating type switching is not considered a type of phenotypic switching: for mating type switching, consider instead annotating to 'mating type switching ; GO:0007533'. bf 2012-03-27T01:31:28Z biological_process owl:Class
GO:0085036 biolink:NamedThing extrahaustorial matrix The space between the symbiont plasma membrane and the extrahaustorial membrane of the host. got7fsn_ti See also: haustorium ; GO:0085035 and extrahaustorial membrane ; GO:0085037. jl 2010-07-27T03:58:20Z cellular_component owl:Class
GO:1905956 biolink:NamedThing positive regulation of endothelial tube morphogenesis Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis. got7fsn_ti up-regulation of endothelial tube morphogenesis|upregulation of endothelial tube morphogenesis|up regulation of endothelial tube morphogenesis|activation of endothelial tube morphogenesis rph 2017-02-21T15:17:39Z biological_process owl:Class
GO:0030958 biolink:NamedThing RITS complex A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing. got7fsn_ti cellular_component owl:Class
GO:0035748 biolink:NamedThing myelin sheath abaxonal region The region of the myelin sheath furthest from the axon. got7fsn_ti bf 2011-03-23T10:16:14Z cellular_component owl:Class
GO:0035253 biolink:NamedThing ciliary rootlet A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm. got7fsn_ti cilium rootlet|cilial rootlet cellular_component owl:Class
GO:0021869 biolink:NamedThing forebrain ventricular zone progenitor cell division The mitotic division of a basal progenitor giving rise to two neurons. got7fsn_ti biological_process owl:Class
GO:0060637 biolink:NamedThing positive regulation of lactation by mesenchymal-epithelial cell signaling The process that increases the rate, frequency, or extent of lactation as a result of the secretion of a signal from the mammary fat and its reception by a mammary epithelial cell. got7fsn_ti positive regulation of lactation by mesenchymal-epithelial cell signalling dph 2009-05-19T03:39:24Z biological_process owl:Class
GO:0098849 biolink:NamedThing cellular detoxification of cadmium ion Any process that reduces or removes the toxicity of cadmium cations in a cell. These include transport of cadmium cations away from sensitive areas and to compartments or complexes whose purpose is sequestration. got7fsn_ti biological_process owl:Class
GO:0071276 biolink:NamedThing cellular response to cadmium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. got7fsn_ti cellular response to cadmium mah 2009-12-10T03:54:49Z biological_process owl:Class
GO:0035043 biolink:NamedThing male pronuclear envelope synthesis Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation. got7fsn_ti biological_process owl:Class
GO:0035039 biolink:NamedThing male pronucleus assembly The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division. got7fsn_ti male pronucleus formation biological_process owl:Class
GO:0030316 biolink:NamedThing osteoclast differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. got7fsn_ti osteoclast cell differentiation biological_process owl:Class
GO:0045239 biolink:NamedThing tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. got7fsn_ti TCA cycle enzyme complex cellular_component owl:Class
GO:0098501 biolink:NamedThing polynucleotide dephosphorylation The process of removing one or more phosphate groups from a polynucleotide. got7fsn_ti dos 2013-09-18T14:49:10Z biological_process owl:Class
GO:0045729 biolink:NamedThing respiratory burst at fertilization The phase of elevated metabolic activity, during which oxygen consumption increases, that occurs at fertilization. An enhanced uptake of oxygen leads to the production of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. Capacitation, a necessary prerequisite event to successful fertilization, can be induced by reactive oxygen species in vitro; hydrogen peroxide is used as an extracellular oxidant to cross-link the protective surface envelopes. got7fsn_ti metabolic burst at fertilization|oxidative burst at fertilization biological_process owl:Class
GO:1905027 biolink:NamedThing regulation of membrane depolarization during AV node cell action potential Any process that modulates the frequency, rate or extent of membrane depolarization during AV node cell action potential. got7fsn_ti regulation of membrane depolarization during AV node cardiac muscle cell action potential|regulation of membrane depolarization during atrioventricular node cardiac muscle cell action potential rph 2016-03-04T13:46:06Z biological_process owl:Class
GO:0086016 biolink:NamedThing AV node cell action potential An action potential that occurs in an atrioventricular node cardiac muscle cell. got7fsn_ti AV node cardiac muscle cell action potential|atrioventricular node cardiac muscle cell action potential tb 2011-11-10T08:58:56Z biological_process owl:Class
GO:0120157 biolink:NamedThing PAR polarity complex A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. got7fsn_ti BEM1-CDC24-CLA4 complex|PAR6-PAR3-aPKC complex|apical polarity complex|Cdc42p GEF-PAK complex|PAR3-PAR6-atypical PKC|PAR3/PAR6/aPKC "This tripartite complex named PAR6/PAR3/aPKC is conserved from worms to vertebrates" (PMID:18005931). In yeast, the components are BEM1, CDC24, and CLA4. krc 2018-05-11T15:41:30Z cellular_component owl:Class
GO:0035023 biolink:NamedThing regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. got7fsn_ti biological_process owl:Class
GO:0006998 biolink:NamedThing nuclear envelope organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. got7fsn_ti nuclear envelope organisation|nuclear envelope organization and biogenesis biological_process owl:Class
GO:0010256 biolink:NamedThing endomembrane system organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. got7fsn_ti endomembrane system organisation|endomembrane organization biological_process owl:Class
GO:0003147 biolink:NamedThing neural crest cell migration involved in heart formation The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation. got7fsn_ti tb 2009-09-22T04:29:55Z biological_process owl:Class
GO:0061308 biolink:NamedThing cardiac neural crest cell development involved in heart development The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart. got7fsn_ti dph 2010-09-23T09:01:49Z biological_process owl:Class
GO:0015126 biolink:NamedThing canalicular bile acid transmembrane transporter activity The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. got7fsn_ti molecular_function owl:Class
GO:0043312 biolink:NamedThing neutrophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil. got7fsn_ti neutrophil granule exocytosis|heterophil degranulation biological_process owl:Class
GO:0002446 biolink:NamedThing neutrophil mediated immunity Any process involved in the carrying out of an immune response by a neutrophil. got7fsn_ti biological_process owl:Class
GO:0097091 biolink:NamedThing synaptic vesicle clustering The process that results in grouping synaptic vesicles in presynaptic structures. got7fsn_ti https://github.com/geneontology/synapse/issues/163 pr 2011-07-04T01:48:24Z biological_process owl:Class
GO:0099504 biolink:NamedThing synaptic vesicle cycle A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. got7fsn_ti biological_process owl:Class
GO:0048163 biolink:NamedThing scattered antral spaces stage The stage in oogenesis when antral spaces begin to form in the follicle cells. Mitochondria form centers for yolk concentration. got7fsn_ti mammalian oogenesis stage 6 biological_process owl:Class
GO:0061203 biolink:NamedThing striated muscle paramyosin thick filament assembly The aggregation, arrangement and bonding together of proteins to form the paramyosin-based thick filaments of myofibrils in striated muscle. got7fsn_ti dph 2010-07-29T12:22:31Z biological_process owl:Class
GO:1990394 biolink:NamedThing cellular response to cell wall damage Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell wall damage. The process begins with detection of the damage and ends with a change in state or activity of the cell. got7fsn_ti al 2014-06-05T16:45:33Z biological_process owl:Class
GO:0071433 biolink:NamedThing cell wall repair A process of cell wall organization that results in the restoration of the cell wall following damage. got7fsn_ti mah 2009-12-16T11:00:50Z biological_process owl:Class
GO:0050902 biolink:NamedThing leukocyte adhesive activation The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation. got7fsn_ti leukocyte adhesive triggering biological_process owl:Class
NCBITaxon:131567 biolink:NamedThing got7fsn_ti owl:Class
GO:0007285 biolink:NamedThing primary spermatocyte growth The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis. got7fsn_ti biological_process owl:Class
GO:0120309 biolink:NamedThing cilium attachment to cell body A process that is carried out at the cellular level which results in the lateral attachment of the cilium to the cell body via the flagellar attachment zone in some trypanosomatid species. got7fsn_ti cilial attachment to cell body|ciliary attachment to cell body|flagellum attachment to cell body|flagellar attachment to cell body krc 2021-03-23T18:01:14Z biological_process owl:Class
NCBITaxon:5653 biolink:NamedThing got7fsn_ti owl:Class
GO:0009566 biolink:NamedThing fertilization The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). got7fsn_ti syngamy https://github.com/geneontology/go-ontology/issues/20176 Wikipedia:Fertilisation biological_process owl:Class
GO:0005960 biolink:NamedThing glycine cleavage complex A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. got7fsn_ti glycine dehydrogenase (decarboxylating) complex|glycine decarboxylase complex|glycine dehydrogenase complex (decarboxylating)|glycine cleavage system|glycine synthase complex GO:0005961|GO:0070015 Wikipedia:Glycine_decarboxylase_complex cellular_component owl:Class
GO:0014906 biolink:NamedThing myotube cell development involved in skeletal muscle regeneration The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. got7fsn_ti biological_process owl:Class
GO:0014908 biolink:NamedThing myotube differentiation involved in skeletal muscle regeneration The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. got7fsn_ti biological_process owl:Class
GO:0106125 biolink:NamedThing reservosome matrix A matrix composed of planar membranes, vesicles and lipid inclusions within the reservosome. got7fsn_ti hjd 2018-05-03T18:00:03Z cellular_component owl:Class
NCBITaxon:47570 biolink:NamedThing got7fsn_ti owl:Class
GO:0035060 biolink:NamedThing brahma complex A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof. got7fsn_ti BRM complex cellular_component owl:Class
GO:0019862 biolink:NamedThing IgA binding Binding to an immunoglobulin of an IgA isotype. got7fsn_ti molecular_function owl:Class
GO:0072766 biolink:NamedThing centromere clustering at the mitotic interphase nuclear envelope The process in which chromatin, or kinetochores are anchored to the nuclear envelope. This process involves the microtubule cytoskeleton, and nuclear tethering factors and is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei. got7fsn_ti kinetochore clustering at the old mitotic spindle pole body|centromere clustering at the nuclear periphery|rabl configuration|kinetochore clustering at spindle pole body|kinetochore localization at spindle pole body|centromere-SPB clustering|centromere clustering at the mitotic nuclear envelope|kinetochore clustering at SPB https://github.com/geneontology/go-ontology/issues/19227|https://github.com/geneontology/go-ontology/issues/20122 mah 2012-11-21T13:32:22Z biological_process owl:Class
CHEBI:17996 biolink:NamedThing got7fsn_ti owl:Class
GO:0048570 biolink:NamedThing notochord morphogenesis The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. got7fsn_ti biological_process owl:Class
GO:0036507 biolink:NamedThing protein demannosylation The removal of one or more mannose residues from a mannosylated protein. got7fsn_ti protein de-mannosylation Consider also annotating to the term 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. bf 2015-06-11T13:57:01Z biological_process owl:Class
GO:0072288 biolink:NamedThing metanephric proximal tubule morphogenesis The process in which the anatomical structures of a metanephric proximal tubule are generated and organized. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology. got7fsn_ti mah 2010-04-09T03:42:03Z biological_process owl:Class
GO:0070825 biolink:NamedThing micropyle An external encapsulating structure part of the chorion. A single cone-shaped specialization that forms an opening in the egg chorion that allows sperm entry into the egg prior to fertilization. got7fsn_ti mah 2009-07-21T05:33:09Z cellular_component owl:Class
GO:0048132 biolink:NamedThing female germ-line stem cell asymmetric division The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes. got7fsn_ti female germ-line stem cell renewal GO:0048141 biological_process owl:Class
GO:0007462 biolink:NamedThing R1/R6 cell fate commitment The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres. got7fsn_ti biological_process owl:Class
GO:0048052 biolink:NamedThing R1/R6 cell differentiation The process in which relatively unspecialized cells acquire the specialized features of R1 and R6 photoreceptors. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0099078 biolink:NamedThing BORC complex A protein complex that is invovled in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors. got7fsn_ti cellular_component owl:Class
GO:0032418 biolink:NamedThing lysosome localization Any process in which a lysosome is transported to, and/or maintained in, a specific location. got7fsn_ti lysosome localisation biological_process owl:Class
GO:0008069 biolink:NamedThing dorsal/ventral axis specification, ovarian follicular epithelium Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster. got7fsn_ti dorsal/ventral axis determination, ovarian follicular epithelium|dorsal/ventral axis determination, follicular epithelium|dorsoventral axis specification, ovarian follicular epithelium|dorsal-ventral axis specification, ovarian follicular epithelium biological_process owl:Class
GO:0031054 biolink:NamedThing pre-miRNA processing Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule. got7fsn_ti pre-microRNA processing biological_process owl:Class
GO:1904564 biolink:NamedThing Nbp35-Cfd1 ATPase complex An iron-sulfur cluster assembly complex that is capable of weak ATPase activity. In yeast it consists of two subunits, Nbp35 and Cfd1. got7fsn_ti rb 2015-08-18T22:50:29Z cellular_component owl:Class
GO:0016887 biolink:NamedThing ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ Pi. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. got7fsn_ti adenosinetriphosphatase activity|ATP monophosphatase activity|adenosine triphosphatase activity|adenosine 5'-triphosphatase activity|ATP phosphohydrolase activity|ATPase|ATP hydrolase activity https://github.com/geneontology/go-ontology/issues/20498|https://github.com/geneontology/go-ontology/issues/19078|https://github.com/geneontology/go-ontology/issues/21612 Note that this term is meant to specifically represent the ATPase activity of proteins using ATPase as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function. GO:0004002|GO:0042623 Reactome:R-HSA-9706399|Reactome:R-HSA-6811422|Reactome:R-HSA-5654989|Reactome:R-HSA-5694425|Reactome:R-HSA-917693|Reactome:R-HSA-6814670|Reactome:R-HSA-159101|Reactome:R-HSA-9668415|Reactome:R-HSA-72139|Reactome:R-HSA-5618093|Reactome:R-HSA-6814683|Reactome:R-HSA-6809015|Reactome:R-HSA-9609860|Reactome:R-HSA-8868658|Reactome:R-HSA-6814678|Reactome:R-HSA-8847638|Reactome:R-HSA-8939203|Reactome:R-HSA-416985|RHEA:13065|Reactome:R-HSA-3371422|Reactome:R-HSA-9038161 molecular_function owl:Class
GO:0070724 biolink:NamedThing BMP receptor complex A protein complex that acts as a receptor for bone morphogenetic proteins (BMPs); a homo- or heterodimer of type I and/or type II BMP receptor subunits. got7fsn_ti bone morphogenetic protein receptor complex mah 2009-06-15T02:34:27Z cellular_component owl:Class
GO:0004911 biolink:NamedThing interleukin-2 receptor activity Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-2R|IL-2 receptor activity molecular_function owl:Class
GO:0038110 biolink:NamedThing interleukin-2-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-2-mediated signaling pathway|interleukin-2-mediated signalling pathway bf 2012-03-22T10:18:29Z biological_process owl:Class
GO:0004912 biolink:NamedThing interleukin-3 receptor activity Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-3 receptor activity|IL-3R Wikipedia:Interleukin-3_receptor molecular_function owl:Class
GO:0071553 biolink:NamedThing G protein-coupled pyrimidinergic nucleotide receptor activity Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G-protein coupled pyrimidinergic nucleotide receptor activity|pyrimidinergic nucleotide receptor activity, G-protein coupled|G protein coupled pyrimidinergic nucleotide receptor activity|pyrimidinergic nucleotide receptor activity, G protein coupled mah 2010-01-13T03:13:22Z molecular_function owl:Class
GO:0019103 biolink:NamedThing pyrimidine nucleotide binding Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate. got7fsn_ti molecular_function owl:Class
GO:0010207 biolink:NamedThing photosystem II assembly The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on the thylakoid membrane. The photosystem II complex consists of at least 20 polypeptides and around 80 cofactors in most organisms. got7fsn_ti biological_process owl:Class
GO:0031968 biolink:NamedThing organelle outer membrane The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope. got7fsn_ti cellular_component owl:Class
GO:0033759 biolink:NamedThing flavone synthase activity Catalysis of the reaction: a flavanone + 2-oxoglutarate + O2 = a flavone + succinate + CO2 + H2O. got7fsn_ti flavone synthase I activity|FNS I|flavanone,2-oxoglutarate:oxygen oxidoreductase (dehydrating) activity EC:1.14.20.5|RHEA:10448|MetaCyc:RXN-8000 molecular_function owl:Class
GO:0000749 biolink:NamedThing response to pheromone triggering conjugation with cellular fusion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti response to pheromone during conjugation with cellular fusion GO:0007328|GO:0030434 biological_process owl:Class
GO:0099574 biolink:NamedThing regulation of protein catabolic process at synapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating protein degradation at the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0036055 biolink:NamedThing protein-succinyllysine desuccinylase activity Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. got7fsn_ti succinyl lysine desuccinylase activity|succinyllysine desuccinylase activity|peptidyl-succinyllysine desuccinylase activity This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide. bf 2011-12-12T01:33:51Z RHEA:47668 molecular_function owl:Class
GO:0036049 biolink:NamedThing peptidyl-lysine desuccinylation The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein. got7fsn_ti bf 2011-12-12T09:44:54Z biological_process owl:Class
GO:0021993 biolink:NamedThing initiation of neural tube closure The process in which closure points are established at multiple points and along the neural rostrocaudal axis. got7fsn_ti biological_process owl:Class
GO:0001843 biolink:NamedThing neural tube closure The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline. got7fsn_ti biological_process owl:Class
GO:0042680 biolink:NamedThing compound eye cone cell fate determination The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti GO:0042677 biological_process owl:Class
GO:0042676 biolink:NamedThing compound eye cone cell fate commitment The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type. got7fsn_ti GO:0007466 biological_process owl:Class
GO:0044386 biolink:NamedThing integral to host endoplasmic reticulum membrane Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell. got7fsn_ti jl 2011-12-13T04:11:30Z cellular_component owl:Class
GO:0003316 biolink:NamedThing establishment of myocardial progenitor cell apical/basal polarity The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment. got7fsn_ti myocardial progenitor epithelial polarization dph 2009-10-27T09:01:26Z biological_process owl:Class
GO:0003315 biolink:NamedThing heart rudiment formation The developmental process pertaining to the initial formation of the heart rudiment. got7fsn_ti heart cone formation dph 2009-10-27T08:43:37Z biological_process owl:Class
GO:0016281 biolink:NamedThing eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. got7fsn_ti eukaryotic translation initiation factor 4 complex|eIF-4F cellular_component owl:Class
GO:0097427 biolink:NamedThing microtubule bundle An arrangement of closely apposed microtubules running parallel to each other. got7fsn_ti microtubule fascicle pr 2012-11-07T15:01:27Z NIF_Subcellular:sao1872343973 cellular_component owl:Class
GO:1990509 biolink:NamedThing PYM-mago-Y14 complex Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans. got7fsn_ti PYM-mago-RNA-binding protein 8A complex|wibg-mago-tsu complex An example of this is wibg in Drosophila melanogaster (P82804) in PMID:14968132 (inferred from physical interaction). bhm 2014-10-03T12:52:01Z cellular_component owl:Class
GO:2000624 biolink:NamedThing positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. got7fsn_ti positive regulation of mRNA degradation, nonsense-mediated decay|positive regulation of mRNA catabolic process, nonsense-mediated|positive regulation of nonsense-mediated mRNA decay|positive regulation of nuclear mRNA catabolic process, nonsense-mediated decay|positive regulation of mRNA breakdown, nonsense-mediated decay|positive regulation of mRNA catabolism, nonsense-mediated pr 2011-04-18T03:32:49Z biological_process owl:Class
GO:0014844 biolink:NamedThing myoblast proliferation involved in skeletal muscle regeneration The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0097282 biolink:NamedThing immunoglobulin-mediated neutralization The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin. got7fsn_ti antibody-mediated neutralization pr 2012-03-26T01:55:24Z biological_process owl:Class
GO:0034108 biolink:NamedThing positive regulation of erythrocyte clearance Any process that activates or increases the frequency, rate, or extent of erythrocyte clearance. got7fsn_ti positive regulation of neocytolysis|positive regulation of RBC clearance|positive regulation of red blood cell clearance biological_process owl:Class
GO:0046930 biolink:NamedThing pore complex A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. got7fsn_ti pore-forming toxin activity|channel-forming toxin activity|pore https://github.com/geneontology/go-ontology/issues/20452 cellular_component owl:Class
GO:0007084 biolink:NamedThing mitotic nuclear membrane reassembly The mitotic cell cycle process involving ESCRTIII that results in reformation of the nuclear envelope after mitotic nuclear division. In organisms undergoing closed mitosis this involves resealing or 'repair' of the nuclear envelope in the nuclear bridge. got7fsn_ti nuclear envelope repair|mitotic nuclear envelope reassembly|nuclear envelope resealing https://github.com/geneontology/go-ontology/issues/20636|https://github.com/geneontology/go-ontology/issues/19950 biological_process owl:Class
GO:0030206 biolink:NamedThing chondroitin sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. got7fsn_ti chondroitin sulphate biosynthesis|chondroitin sulfate anabolism|chondroitin sulphate biosynthetic process|chondroitin sulfate formation|chondroitin sulfate biosynthesis|chondroitin sulfate synthesis biological_process owl:Class
GO:0050650 biolink:NamedThing chondroitin sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. got7fsn_ti chondroitin sulfate proteoglycan formation|chondroitin sulfate proteoglycan synthesis|chondroitin sulphate proteoglycan biosynthesis|chondroitin sulphate proteoglycan biosynthetic process|chondroitin sulfate proteoglycan biosynthesis|chondroitin sulfate proteoglycan anabolism biological_process owl:Class
GO:0048623 biolink:NamedThing seed germination on parent plant The process in which a seed germinates before being shed from the parent plant. got7fsn_ti non-vegetative vivipary|vivipary|pre-harvest sprouting biological_process owl:Class
GO:0021512 biolink:NamedThing spinal cord anterior/posterior patterning The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord. got7fsn_ti spinal cord rostrocaudal patterning|spinal cord anterior-posterior patterning biological_process owl:Class
GO:0021511 biolink:NamedThing spinal cord patterning The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord. got7fsn_ti biological_process owl:Class
GO:0001989 biolink:NamedThing positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure. got7fsn_ti positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure|increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure|increased strength of cardiac contraction during baroreceptor response to decreased blood pressure biological_process owl:Class
GO:0060314 biolink:NamedThing regulation of ryanodine-sensitive calcium-release channel activity Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti biological_process owl:Class
GO:0061438 biolink:NamedThing renal system vasculature morphogenesis The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form. got7fsn_ti dph 2012-03-08T12:21:56Z biological_process owl:Class
GO:0021933 biolink:NamedThing radial glia guided migration of cerebellar granule cell The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer. got7fsn_ti biological_process owl:Class
CHEBI:59888 biolink:NamedThing got7fsn_ti owl:Class
GO:0120009 biolink:NamedThing intermembrane lipid transfer The transport of lipids between membranes in which a lipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs). got7fsn_ti https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-16T20:30:42Z biological_process owl:Class
GO:0097527 biolink:NamedThing necroptotic signaling pathway A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered. got7fsn_ti necroptosis signaling pathway|necroptotic signal transduction|necroptosis signaling|necroptotic signalling pathway Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1). This is sometimes referred to as PARP-dependent cell death or parthanatos; it is still being debated if it constitutes an independent cell death modality. pr 2013-11-05T14:17:28Z biological_process owl:Class
GO:0071689 biolink:NamedThing muscle thin filament assembly The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in striated muscle. got7fsn_ti mah 2010-02-25T03:54:06Z biological_process owl:Class
GO:0038004 biolink:NamedThing epidermal growth factor receptor ligand maturation Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor. got7fsn_ti EGFR ligand processing|peptide bond cleavage involved in EGFR ligand maturation|EGFR ligand maturation|peptide bond cleavage involved in epidermal growth factor receptor ligand maturation|epidermal growth factor receptor ligand processing|EGFR ligand maturation by peptide bond cleavage bf 2011-06-07T03:08:41Z GO:0038005 biological_process owl:Class
GO:0044787 biolink:NamedThing bacterial-type DNA replication The DNA-dependent DNA replication, exemplified by prokaryotes, that occurs as part of the cell cycle. Prokaryotic DNA replication is bi-directional and originates at a single origin of replication on the circular genome. got7fsn_ti bacterial-type cell cycle DNA replication jl 2013-05-02T15:54:16Z biological_process owl:Class
GO:0010548 biolink:NamedThing regulation of thylakoid membrane disassembly Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly. got7fsn_ti regulation of thylakoid membrane degradation biological_process owl:Class
GO:0010547 biolink:NamedThing thylakoid membrane disassembly The controlled breakdown of the thylakoid membrane in the context of a normal process. got7fsn_ti thylakoid membrane degradation biological_process owl:Class
GO:1903377 biolink:NamedThing negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. got7fsn_ti downregulation of neuron apoptosis in response to oxidative stress|down regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of neuron apoptosis in response to oxidative stress|down-regulation of neuron apoptosis in response to oxidative stress|down-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|neuroprotection against oxidative stress-induced apoptosis|down regulation of neuron apoptosis in response to oxidative stress|protection against oxidative stress-induced neuron apoptosis|inhibition of neuron apoptosis in response to oxidative stress|downregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of oxidative stress-induced neuron apoptosis|inhibition of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|protection against oxidative stress-induced neuronal apoptosis|negative regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress bf 2014-08-26T13:03:28Z biological_process owl:Class
GO:0051402 biolink:NamedThing neuron apoptotic process Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. got7fsn_ti neuronal cell programmed cell death by apoptosis|programmed cell death, neurons|programmed cell death of neurons by apoptosis|neuron programmed cell death by apoptosis|neuron apoptosis|apoptosis of neuronal cells|programmed cell death, neuronal cells|neuronal cell apoptosis|programmed cell death of neuronal cells by apoptosis|apoptosis of neurons biological_process owl:Class
GO:0099529 biolink:NamedThing neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel). got7fsn_ti molecular_function owl:Class
GO:0030323 biolink:NamedThing respiratory tube development The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract. got7fsn_ti biological_process owl:Class
GO:0035776 biolink:NamedThing pronephric proximal tubule development The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. got7fsn_ti bf 2011-04-04T11:02:54Z biological_process owl:Class
GO:0061305 biolink:NamedThing maintenance of bipolar cell polarity regulating cell shape The maintenance of established bipolar anisotropic intracellular organization or cell growth patterns that results in the shaping of a cell. got7fsn_ti dph 2010-09-16T09:25:18Z biological_process owl:Class
GO:0033577 biolink:NamedThing protein glycosylation in endoplasmic reticulum The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum. got7fsn_ti core glycosylation|protein amino acid glycosylation in endoplasmic reticulum|protein amino acid glycosylation in ER biological_process owl:Class
GO:0007210 biolink:NamedThing serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands. got7fsn_ti serotonin receptor signalling pathway biological_process owl:Class
GO:1903351 biolink:NamedThing cellular response to dopamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus. got7fsn_ti mr 2014-08-19T19:33:35Z biological_process owl:Class
GO:0008353 biolink:NamedThing RNA polymerase II CTD heptapeptide repeat kinase activity Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats. got7fsn_ti [RNA-polymerase]-subunit kinase activity|CTD kinase activity|RNA polymerase II carboxy-terminal domain kinase activity|ATP:DNA-directed RNA polymerase phosphotransferase activity|RNA polymerase subunit kinase activity|STK9|RNA-polymerase-subunit kinase activity EC:2.7.11.23|MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN|RHEA:10216|Reactome:R-HSA-170704|Reactome:R-HSA-167191|Reactome:R-HSA-170706 molecular_function owl:Class
GO:0072246 biolink:NamedThing metanephric glomerular parietal epithelial cell development The process whose specific outcome is the progression of a metanephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. got7fsn_ti metanephric Bowman's capsule development mah 2010-03-19T03:42:13Z biological_process owl:Class
GO:0072245 biolink:NamedThing metanephric glomerular parietal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular parietal epithelial cell. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. got7fsn_ti mah 2010-03-19T03:41:26Z biological_process owl:Class
GO:1903859 biolink:NamedThing regulation of dendrite extension Any process that modulates the frequency, rate or extent of dendrite extension. got7fsn_ti An example of this is Mul1 in mouse (UniProt ID Q8VCM5) in PMID:24898855 inferred from mutant phenotype. pad 2015-02-02T15:33:51Z biological_process owl:Class
GO:0000902 biolink:NamedThing cell morphogenesis The developmental process in which the size or shape of a cell is generated and organized. got7fsn_ti cellular morphogenesis GO:0045790|GO:0045791|GO:0007148 biological_process owl:Class
GO:1904146 biolink:NamedThing positive regulation of meiotic cell cycle process involved in oocyte maturation Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. got7fsn_ti up-regulation of meiotic cell cycle process involved in oocyte maturation|activation of meiotic cell cycle process involved in oocyte maturation|upregulation of meiotic cell cycle process involved in oocyte maturation|up regulation of meiotic cell cycle process involved in oocyte maturation tb 2015-04-14T15:59:28Z biological_process owl:Class
GO:0060616 biolink:NamedThing mammary gland cord formation The process in which the mammary gland cord forms by elongation of the mammary bud. The cord is formed once the elongating bud breaks through the mesenchyme and reaches the fat pad. got7fsn_ti mammary gland sprout formation dph 2009-05-18T08:57:58Z biological_process owl:Class
GO:0032126 biolink:NamedThing eisosome A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization. got7fsn_ti Wikipedia:Eisosome cellular_component owl:Class
GO:0016332 biolink:NamedThing establishment or maintenance of polarity of embryonic epithelium Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo. got7fsn_ti biological_process owl:Class
GO:2001268 biolink:NamedThing negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. got7fsn_ti negative regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway|negative regulation of initiator caspase activity pr 2011-12-13T07:56:21Z biological_process owl:Class
GO:0140041 biolink:NamedThing cellular detoxification of methylglyoxal Any process carried out at the cellular level that reduces or removes the toxicity of methylglyoxal. got7fsn_ti pg 2017-06-16T09:43:30Z biological_process owl:Class
GO:0060100 biolink:NamedThing positive regulation of phagocytosis, engulfment Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. got7fsn_ti biological_process owl:Class
GO:0021886 biolink:NamedThing hypothalamus gonadotrophin-releasing hormone neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter. got7fsn_ti hypothalamus gonadotropin-releasing hormone neuron differentiation biological_process owl:Class
GO:0021667 biolink:NamedThing rhombomere 6 morphogenesis The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0021572 biolink:NamedThing rhombomere 6 development The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0005688 biolink:NamedThing U6 snRNP A ribonucleoprotein complex that contains small nuclear RNA U6, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6 snRNP, most of which remain associated with the U6 snRNA both while the U6 snRNP is free or assembled into the U4/U6 snRNP or into a series of spliceosomal complexes. got7fsn_ti snRNP U6 cellular_component owl:Class
GO:0120115 biolink:NamedThing Lsm2-8 complex A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus. got7fsn_ti krc 2017-11-06T18:56:22Z cellular_component owl:Class
GO:0071001 biolink:NamedThing U4/U6 snRNP A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes. got7fsn_ti mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0097014 biolink:NamedThing ciliary plasm All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. got7fsn_ti microtubule-based flagellum cytoplasm|microtubule-based flagellar matrix|microtubule-based flagellar cytoplasm|microtubule-based flagellum matrix|cilial cytoplasm|ciliary cytoplasm|cilium plasm|cilium cytoplasm Note that we deem cilium and microtubule-based flagellum to be equivalent. Also, researchers consider the composition of both the plasm and the membrane of the cilium to be detectably different from that in the non-ciliary cytosol and plasma membrane (e.g. in terms of calcium ion concentration, membrane lipid composition, and more). For this reason, the term "ciliary plasm" is not linked to "cytoplasm". pr 2011-03-23T01:52:31Z cellular_component owl:Class
GO:0015552 biolink:NamedThing propionate transmembrane transporter activity Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH. got7fsn_ti molecular_function owl:Class
GO:0015730 biolink:NamedThing propanoate transport The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti propionate transport biological_process owl:Class
GO:0062097 biolink:NamedThing chemosynthesis The cellular metabolic process in which organic chemical compounds are synthesized from carbon-containing molecules and nutrients using energy obtained from the oxidation of inorganic compounds or methane. got7fsn_ti dph 2018-11-29T13:18:55Z Wikipedia:Chemosynthesis biological_process owl:Class
GO:0097561 biolink:NamedThing right caudal flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body. got7fsn_ti right caudal cilium Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T13:31:15Z cellular_component owl:Class
GO:0090395 biolink:NamedThing plant cell papilla A cell projection that is a short, rounded projection from a plant epidermal cell. got7fsn_ti Part of papilla cell (PO:0025166), which is a shoot epidermal cell (PO:0025165) in plants. Replaces the obsolete term papillae (PO:0002001). tb 2010-12-15T03:26:20Z cellular_component owl:Class
GO:0030937 biolink:NamedThing collagen type XVII trimer A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin. got7fsn_ti cellular_component owl:Class
GO:0030056 biolink:NamedThing hemidesmosome A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces. got7fsn_ti trans-epithelial attachment|fibrous organelle|epidermal attachment structure|hemi-adherens junction Wikipedia:Hemidesmosome cellular_component owl:Class
GO:1900248 biolink:NamedThing negative regulation of cytoplasmic translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation. got7fsn_ti downregulation of cytoplasmic translational elongation|down regulation of cytoplasmic translational elongation|down-regulation of cytoplasmic translational elongation|inhibition of cytoplasmic translational elongation vw 2012-04-03T05:07:14Z biological_process owl:Class
GO:0002181 biolink:NamedThing cytoplasmic translation The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein. got7fsn_ti Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms. hjd 2011-06-09T03:11:53Z biological_process owl:Class
GO:0021543 biolink:NamedThing pallium development The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon. got7fsn_ti biological_process owl:Class
GO:0021537 biolink:NamedThing telencephalon development The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived. got7fsn_ti cerebrum development biological_process owl:Class
GO:0035037 biolink:NamedThing sperm entry An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur. got7fsn_ti biological_process owl:Class
GO:0090440 biolink:NamedThing abscisic acid transmembrane transporter activity Enables the transfer of abscisic acid from one side of a membrane to the other. got7fsn_ti abscisic acid transporter activity tb 2012-08-20T14:29:42Z molecular_function owl:Class
GO:0080168 biolink:NamedThing abscisic acid transport The directed movement of abscisic acid into, out of, within or between cells by means of some external agent such as a transporter or pore. got7fsn_ti dhl 2010-09-23T05:08:56Z biological_process owl:Class
GO:0043194 biolink:NamedThing axon initial segment Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. got7fsn_ti initial segment NIF_Subcellular:sao256000789 cellular_component owl:Class
GO:0044304 biolink:NamedThing main axon The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites. got7fsn_ti axon shaft|axon trunk|axonal shaft jl 2010-02-05T03:48:17Z NIF_Subcellular:sao1596975044 cellular_component owl:Class
GO:0120307 biolink:NamedThing Hechtian strand An extended membranous thread which firmly connects the plasma membrane to the cell wall during plasmolysis such that the plasma membrane does not separate from the cell wall completely. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21138 krc 2021-03-19T20:31:15Z Wikipedia:Hechtian_strand cellular_component owl:Class
GO:0002341 biolink:NamedThing central B cell anergy Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow. got7fsn_ti central B-cell anergy|central B-lymphocyte anergy|central B lymphocyte anergy biological_process owl:Class
GO:0045265 biolink:NamedThing proton-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core. got7fsn_ti hydrogen-transporting ATP synthase, stator stalk cellular_component owl:Class
GO:0044692 biolink:NamedThing exoribonuclease activator activity Binds to and increases the activity of an exoribonuclease. got7fsn_ti jl 2012-08-15T15:13:57Z molecular_function owl:Class
GO:0032075 biolink:NamedThing positive regulation of nuclease activity Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. got7fsn_ti stimulation of nuclease activity|upregulation of nuclease activity|up regulation of nuclease activity|activation of nuclease activity|nuclease activator|up-regulation of nuclease activity biological_process owl:Class
GO:0009920 biolink:NamedThing cell plate formation involved in plant-type cell wall biogenesis The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana. got7fsn_ti cell plate formation involved in cellulose and pectin-containing cell wall biogenesis biological_process owl:Class
CL:0000066 biolink:NamedThing got7fsn_ti owl:Class
GO:0005347 biolink:NamedThing ATP transmembrane transporter activity Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other. got7fsn_ti GO:0005348 molecular_function owl:Class
GO:0015867 biolink:NamedThing ATP transport The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0098651 biolink:NamedThing basement membrane collagen trimer Any collagen timer that is part of a basement membrane. got7fsn_ti cellular_component owl:Class
GO:0033009 biolink:NamedThing nucleomorph A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively. got7fsn_ti Wikipedia:Nucleomorph cellular_component owl:Class
GO:0045467 biolink:NamedThing R7 cell development The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium. got7fsn_ti biological_process owl:Class
GO:1990965 biolink:NamedThing cytosylglucuronate decarboxylase activity Catalysis of the reaction: cytosylglucuronic acid + H(+) = cytosylarabinopyranose + CO(2). got7fsn_ti This enzymatic activity was shown to be involved in the bacterial blasticidin S biosynthetic pathway. pr 2016-06-09T13:05:27Z molecular_function owl:Class
GO:0080155 biolink:NamedThing regulation of double fertilization forming a zygote and endosperm Any process that modulates the rate, frequency or extent of double fertilization forming a zygote and endosperm. Double fertilization forming a zygote and endosperm is a type of fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana. got7fsn_ti dhl 2010-09-01T03:46:39Z biological_process owl:Class
GO:0009567 biolink:NamedThing double fertilization forming a zygote and endosperm Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana. got7fsn_ti double fertilization biological_process owl:Class
GO:2001206 biolink:NamedThing positive regulation of osteoclast development Any process that activates or increases the frequency, rate or extent of osteoclast development. got7fsn_ti positive regulation of osteoclast cell development yaf 2011-11-10T10:59:12Z biological_process owl:Class
GO:1990850 biolink:NamedThing H-gal-GP complex A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus. got7fsn_ti galactose-containing glycoprotein complex|Haemonchus galactose-containing glycoprotein complex jl 2015-09-10T16:40:39Z cellular_component owl:Class
GO:0072220 biolink:NamedThing metanephric descending thin limb development The process whose specific outcome is the progression of the metanephric descending thin limb over time, from its formation to the mature structure. The metanephric descending thin limb is a part of the metanephric loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the metanephric loop of Henle. got7fsn_ti mah 2010-03-18T03:35:05Z biological_process owl:Class
GO:0072236 biolink:NamedThing metanephric loop of Henle development The process whose specific outcome is the progression of the metanephric loop of Henle over time, from its formation to the mature structure. The metanephric loop of Henle is a metanephric nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule in the metanephros. got7fsn_ti metanephric intermediate tubule development mah 2010-03-18T03:46:18Z biological_process owl:Class
GO:0002815 biolink:NamedThing biosynthetic process of antibacterial peptides active against Gram-positive bacteria The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria. got7fsn_ti biological_process owl:Class
GO:0009505 biolink:NamedThing plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. got7fsn_ti cellulose and pectin-containing cell wall|plant cell wall cellular_component owl:Class
GO:0048854 biolink:NamedThing brain morphogenesis The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). got7fsn_ti biological_process owl:Class
GO:0007420 biolink:NamedThing brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). got7fsn_ti biological_process owl:Class
GO:1901254 biolink:NamedThing positive regulation of intracellular transport of viral material Any process that activates or increases the frequency, rate or extent of intracellular transport of viral material. got7fsn_ti up-regulation of movement of virus within host cell|positive regulation of viral egress|upregulation of egress of virus within host cell|upregulation of viral egress|up regulation of viral egress|activation of movement of virus within host cell|positive regulation of egress of virus within host cell|up-regulation of viral egress|up regulation of movement of virus within host cell|up regulation of egress of virus within host cell|upregulation of movement of virus within host cell|activation of viral egress|activation of egress of virus within host cell|positive regulation of movement of virus within host cell|up-regulation of egress of virus within host cell ss 2012-08-09T05:45:54Z biological_process owl:Class
GO:0019058 biolink:NamedThing viral life cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. got7fsn_ti viral infectious cycle|viral replication|lytic viral life cycle|viral assembly, maturation, egress, and release GO:0019067 biological_process owl:Class
GO:0009545 biolink:NamedThing elaioplast A leucoplast in which oil is stored. got7fsn_ti Wikipedia:Elaioplast cellular_component owl:Class
GO:0001705 biolink:NamedThing ectoderm formation The formation of ectoderm during gastrulation. got7fsn_ti biological_process owl:Class
GO:0000745 biolink:NamedThing nuclear migration involved in conjugation with mutual genetic exchange The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion. got7fsn_ti nuclear exchange during conjugation without cellular fusion|nuclear migration involved in conjugation without cellular fusion biological_process owl:Class
GO:0000744 biolink:NamedThing karyogamy involved in conjugation with mutual genetic exchange During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena. got7fsn_ti karyogamy involved in conjugation without cellular fusion https://github.com/geneontology/go-ontology/issues/16248 biological_process owl:Class
GO:0072379 biolink:NamedThing ER membrane insertion complex A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast. got7fsn_ti endoplasmic reticulum membrane insertion complex mah 2010-11-24T02:07:09Z cellular_component owl:Class
GO:0009544 biolink:NamedThing chloroplast ATP synthase complex The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts. got7fsn_ti cellular_component owl:Class
GO:0070263 biolink:NamedThing external side of fungal-type cell wall The side of the fungal-type cell wall that is opposite to the side that faces the cell and its contents. got7fsn_ti cellular_component owl:Class
GO:0014817 biolink:NamedThing skeletal muscle satellite cell fate specification The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0014813 biolink:NamedThing skeletal muscle satellite cell commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell. got7fsn_ti biological_process owl:Class
GO:0061558 biolink:NamedThing cranial ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state. got7fsn_ti cranial ganglia maturation dph 2013-07-10T08:59:52Z biological_process owl:Class
GO:2000034 biolink:NamedThing regulation of seed maturation Any process that modulates the frequency, rate or extent of seed maturation. got7fsn_ti tb 2010-08-05T11:33:33Z biological_process owl:Class
GO:0005662 biolink:NamedThing DNA replication factor A complex A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. got7fsn_ti RPA|replication protein A Wikipedia:Replication_protein_A cellular_component owl:Class
GO:0043601 biolink:NamedThing nuclear replisome A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. got7fsn_ti cellular_component owl:Class
GO:0010072 biolink:NamedThing primary shoot apical meristem specification The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers. got7fsn_ti embryo shoot apical meristem specification biological_process owl:Class
GO:0005641 biolink:NamedThing nuclear envelope lumen The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. got7fsn_ti nuclear intermembrane space|perinuclear space|nuclear membrane lumen Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. GO:0005653 cellular_component owl:Class
GO:1904236 biolink:NamedThing negative regulation of substrate-dependent cell migration, cell attachment to substrate Any process that stops, prevents or reduces the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. got7fsn_ti inhibition of substrate-dependent cell migration, cell attachment to substrate|down regulation of substrate-bound cell migration, cell attachment to substrate|down-regulation of substrate-dependent cell migration, cell attachment to substrate|inhibition of substrate-bound cell migration, cell attachment to substrate|down regulation of substrate-dependent cell migration, cell attachment to substrate|down-regulation of substrate-bound cell migration, cell attachment to substrate|downregulation of substrate-bound cell migration, cell attachment to substrate|downregulation of substrate-dependent cell migration, cell attachment to substrate|negative regulation of substrate-bound cell migration, cell attachment to substrate pga 2015-05-15T13:30:05Z biological_process owl:Class
GO:0060524 biolink:NamedThing dichotomous subdivision of prostate epithelial cord terminal unit The process in which a prostate epithelial cord bifurcates at its end. got7fsn_ti prostate epithelial cord bifurcation biological_process owl:Class
GO:0060442 biolink:NamedThing branching involved in prostate gland morphogenesis The process in which the branching structure of the prostate gland is generated and organized. A branch is a division or offshoot from a main stem. got7fsn_ti prostate gland branching morphogenesis|prostate branching biological_process owl:Class
GO:0042959 biolink:NamedThing alkanesulfonate transmembrane transporter activity Enables the directed movement of alkanesulfonate from one side of a membrane to the other. got7fsn_ti alkanesulphonate transporter activity|alkanesulfonate transporter activity molecular_function owl:Class
GO:0042918 biolink:NamedThing alkanesulfonate transport The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical. got7fsn_ti alkanesulphonate transport biological_process owl:Class
GO:0010299 biolink:NamedThing detoxification of cobalt ion Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion. got7fsn_ti biological_process owl:Class
GO:0005743 biolink:NamedThing mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. got7fsn_ti inner mitochondrial membrane|mitochondrion inner membrane|inner mitochondrion membrane Wikipedia:Inner_mitochondrial_membrane|NIF_Subcellular:sao1371347282 cellular_component owl:Class
GO:1902758 biolink:NamedThing bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process The chemical reactions and pathways resulting in the formation of bis(molybdopterin guanine dinucleotide)molybdenum. got7fsn_ti bis(molybdopterin guanine dinucleotide)molybdenum biosynthesis|bis-Mo-molybdopterin-guanine dinucleotide cofactor biosynthetic process|bis(molybdopterin guanine dinucleotide)molybdenum formation|bis(molybdopterin guanine dinucleotide)molybdenum synthesis|bis(molybdopterin guanine dinucleotide)molybdenum anabolism dph 2014-03-06T13:58:18Z GO:0061600 MetaCyc:PWY-5964 biological_process owl:Class
GO:0061603 biolink:NamedThing molybdenum cofactor guanylyltransferase activity Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor. got7fsn_ti dph 2014-02-10T14:54:36Z RHEA:34243|EC:2.7.7.77 molecular_function owl:Class
GO:0014034 biolink:NamedThing neural crest cell fate commitment The process in which a cell becomes committed to become a neural crest cell. got7fsn_ti biological_process owl:Class
GO:0014029 biolink:NamedThing neural crest formation The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes. got7fsn_ti biological_process owl:Class
GO:2000275 biolink:NamedThing regulation of oxidative phosphorylation uncoupler activity Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity. got7fsn_ti regulation of uncoupling protein activity|regulation of mitochondrial uncoupling protein activity mah 2010-12-07T12:14:54Z biological_process owl:Class
GO:0050953 biolink:NamedThing sensory perception of light stimulus The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti biological_process owl:Class
GO:0120109 biolink:NamedThing mitotic telomere clustering and tethering at nuclear periphery The process in which the telomeres are gathered together to a small number of foci per chromosome (usually one per chromosome or fewer), and moved to and tethered at the nuclear periphery, as part of a mitotic cell cycle. got7fsn_ti krc 2017-11-01T18:04:37Z biological_process owl:Class
GO:0036355 biolink:NamedThing 2-iminoacetate synthase activity Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+. got7fsn_ti bf 2012-09-19T14:52:51Z EC:4.1.99.19|RHEA:26361|MetaCyc:RXN-11319 molecular_function owl:Class
GO:0044695 biolink:NamedThing Dsc E3 ubiquitin ligase complex An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism. got7fsn_ti jl 2012-08-16T13:41:48Z cellular_component owl:Class
GO:0031370 biolink:NamedThing eukaryotic initiation factor 4G binding Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation. got7fsn_ti eIF4G binding molecular_function owl:Class
GO:0042919 biolink:NamedThing benzoate transport The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0000390 biolink:NamedThing spliceosomal complex disassembly Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure. got7fsn_ti U2-type spliceosome disassembly|spliceosome complex disassembly|U12-type spliceosome disassembly|spliceosome disassembly GO:0000391|GO:0000392 biological_process owl:Class
GO:0000398 biolink:NamedThing mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. got7fsn_ti pre-mRNA splicing|mRNA splicing|nuclear mRNA splicing, via spliceosome|splicing GT-AG intron|splicing AT-AC intron|nuclear mRNA splicing via U2-type spliceosome|nuclear mRNA splicing via U12-type spliceosome Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. GO:0006374|GO:0006375 biological_process owl:Class
GO:0008364 biolink:NamedThing pupal chitin-based cuticle development Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster. got7fsn_ti pupal cuticle synthesis|pupal cuticle anabolism|pupal cuticle formation biological_process owl:Class
GO:0044725 biolink:NamedThing chromatin reprogramming in the zygote The global reprogramming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process. got7fsn_ti jl 2012-10-24T13:53:28Z biological_process owl:Class
GO:0038176 biolink:NamedThing positive regulation of SREBP signaling pathway in response to decreased oxygen levels Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels. got7fsn_ti positive regulation of SREBP-mediated signaling pathway in absence of oxygen|positive regulation of SREBP-mediated signaling pathway in response to decreased oxygen levels bf 2012-07-20T01:30:25Z biological_process owl:Class
GO:0034422 biolink:NamedThing aleurone grain lumen The volume enclosed by the membrane of an aleurone grain. got7fsn_ti cellular_component owl:Class
GO:1905299 biolink:NamedThing negative regulation of intestinal epithelial cell development Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development. got7fsn_ti downregulation of intestinal epithelial cell development|down-regulation of intestinal epithelial cell development|inhibition of intestinal epithelial cell development|down regulation of intestinal epithelial cell development rph 2016-06-30T11:40:55Z biological_process owl:Class
GO:1904020 biolink:NamedThing regulation of G protein-coupled receptor internalization Any process that modulates the frequency, rate or extent of G protein-coupled receptor internalization. got7fsn_ti regulation of G-protein-coupled receptor internalization pga 2015-03-10T17:10:45Z biological_process owl:Class
GO:1905833 biolink:NamedThing negative regulation of microtubule nucleation Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation. got7fsn_ti downregulation of microtubule nucleation|inhibition of microtubule nucleation|down regulation of microtubule nucleation|down-regulation of microtubule nucleation hbye 2017-01-17T12:00:56Z biological_process owl:Class
GO:0046785 biolink:NamedThing microtubule polymerization The addition of tubulin heterodimers to one or both ends of a microtubule. got7fsn_ti microtubule assembly|microtubule formation biological_process owl:Class
GO:0097084 biolink:NamedThing vascular associated smooth muscle cell development The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. got7fsn_ti vascular smooth muscle cell development pr 2011-06-20T04:03:08Z biological_process owl:Class
GO:0043362 biolink:NamedThing nucleate erythrocyte maturation A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus. got7fsn_ti nucleate red blood cell maturation|nucleate RBC maturation biological_process owl:Class
GO:0048823 biolink:NamedThing nucleate erythrocyte development The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti nucleate RBC development|nucleate red blood cell development biological_process owl:Class
GO:0061363 biolink:NamedThing negative regulation of progesterone biosynthesis involved in luteolysis Any process that decreases the rate, frequency or extent of the biosynthesis of progesterone biosynthesis that contributes to luteolysis. got7fsn_ti functional luteolysis dph 2010-10-14T03:08:41Z biological_process owl:Class
GO:0006701 biolink:NamedThing progesterone biosynthetic process The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. got7fsn_ti progesterone biosynthesis|progesterone synthesis|progesterone anabolism|progesterone formation biological_process owl:Class
GO:0035598 biolink:NamedThing N6-threonylcarbomyladenosine methylthiotransferase activity Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A). got7fsn_ti t6A methylthiotransferase activity bf 2010-11-12T01:28:32Z Reactome:R-HSA-6786571 molecular_function owl:Class
GO:0035600 biolink:NamedThing tRNA methylthiolation The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule. got7fsn_ti bf 2010-11-12T01:34:02Z biological_process owl:Class
GO:2000315 biolink:NamedThing positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. got7fsn_ti positive regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation vk 2011-01-18T10:27:19Z biological_process owl:Class
GO:0070902 biolink:NamedThing mitochondrial tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule. got7fsn_ti mah 2009-09-02T04:09:48Z biological_process owl:Class
GO:0061984 biolink:NamedThing catabolite repression A process in which the presence of one nutrient source leads to a decrease in the frequency, rate, or extent of processes involved in the metabolism of other nutrient sources. got7fsn_ti dph 2018-02-15T16:34:14Z biological_process owl:Class
GO:0043093 biolink:NamedThing FtsZ-dependent cytokinesis A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells. got7fsn_ti prokaryotic fission|cytokinesis by binary fission|prokaryote-type cytokinesis Note that this term is intended for the annotation of prokaryotic gene products. Wikipedia:Binary_fission biological_process owl:Class
GO:0001828 biolink:NamedThing inner cell mass cellular morphogenesis The morphogenesis of cells in the inner cell mass. got7fsn_ti See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. biological_process owl:Class
GO:0010876 biolink:NamedThing lipid localization Any process in which a lipid is transported to, or maintained in, a specific location. got7fsn_ti lipid localisation biological_process owl:Class
GO:0035800 biolink:NamedThing deubiquitinase activator activity Binds to and increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences. got7fsn_ti 2011-04-18T10:20:15Z molecular_function owl:Class
GO:2000158 biolink:NamedThing positive regulation of ubiquitin-specific protease activity Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity. got7fsn_ti positive regulation of UBP|positive regulation of ubiquitin hydrolase activity|positive regulation of UCH2|positive regulation of deubiquitinase activity tb 2010-10-04T10:42:29Z biological_process owl:Class
GO:1990658 biolink:NamedThing transnitrosylase complex A transferase complex which is capable of transferring nitrogenous groups from one component to another. got7fsn_ti transferase complex, transferring nitrogenous groups An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). bhm 2015-02-25T11:17:17Z cellular_component owl:Class
GO:2000176 biolink:NamedThing positive regulation of pro-T cell differentiation Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation. got7fsn_ti positive regulation of pro-T lymphocyte differentiation mah 2010-10-11T10:24:35Z biological_process owl:Class
GO:0032290 biolink:NamedThing peripheral nervous system myelin formation The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system. got7fsn_ti myelin formation in peripheral nervous system https://github.com/geneontology/go-ontology/issues/19106 biological_process owl:Class
GO:0050729 biolink:NamedThing positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response. got7fsn_ti activation of inflammatory response|up regulation of inflammatory response|stimulation of inflammatory response|upregulation of inflammatory response|up-regulation of inflammatory response biological_process owl:Class
GO:0097350 biolink:NamedThing neutrophil clearance The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms. got7fsn_ti pr 2012-06-27T03:53:38Z biological_process owl:Class
GO:0036062 biolink:NamedThing presynaptic periactive zone A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development. got7fsn_ti pre-synaptic periactive zone|periactive zone bf 2011-12-14T02:25:29Z cellular_component owl:Class
GO:0097117 biolink:NamedThing guanylate kinase-associated protein clustering The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons. got7fsn_ti GKAP clustering pr 2011-07-31T05:44:35Z biological_process owl:Class
GO:0008065 biolink:NamedThing establishment of blood-nerve barrier The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier. got7fsn_ti establishment of blood/nerve barrier biological_process owl:Class
GO:0007422 biolink:NamedThing peripheral nervous system development The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. got7fsn_ti biological_process owl:Class
CL:0000166 biolink:NamedThing got7fsn_ti owl:Class
GO:2000319 biolink:NamedThing regulation of T-helper 17 cell differentiation Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation. got7fsn_ti regulation of T-helper 17 cell development mah 2011-01-18T01:43:48Z biological_process owl:Class
GO:0072538 biolink:NamedThing T-helper 17 type immune response An immune response which is associated with resistance to intracellular bacteria with a key role in inflammation and tissue injury. This immune response is associated with pathological autoimmune conditions such as multiple sclerosis, arthritis and psoriasis which is typically orchestrated by the production of particular cytokines by T-helper 17 cells, most notably interleukin-17, IL-21 and IL-22. got7fsn_ti Th17 immune response mah 2011-01-17T11:13:53Z biological_process owl:Class
GO:0033105 biolink:NamedThing chlorosome envelope The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome. got7fsn_ti chlorosome membrane Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'. cellular_component owl:Class
NCBITaxon:Union_0000020 biolink:NamedThing got7fsn_ti owl:Class
GO:0043160 biolink:NamedThing acrosomal lumen The volume enclosed within the acrosome membrane. got7fsn_ti cellular_component owl:Class
GO:0001669 biolink:NamedThing acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. got7fsn_ti acrosomal granule|acrosome Wikipedia:Acrosome cellular_component owl:Class
GO:1990686 biolink:NamedThing LDL-containing protein-lipid-RNA complex A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other. got7fsn_ti Examples of LDL-containing protein-lipid-RNA complexes are described in PMID:21423178 and PMID:23559634, both showing evidence that high-density lipoprotein (HDL) and, to a lesser extent, low-density lipoprotein (HDL) transport endogenous microRNAs (miRNAs) and deliver them to recipient cells with functional targeting capabilities. Also see fig. 1 in the review PMID:22028337. Not to be confused with GO:0034362 'low-density lipoprotein particle', which describe complexes of proteins and lipids only, without RNAs. pr 2015-03-11T15:11:34Z cellular_component owl:Class
CHEBI:39026 biolink:NamedThing got7fsn_ti owl:Class
GO:0071683 biolink:NamedThing sensory dendrite A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron. got7fsn_ti mah 2010-02-19T04:17:05Z cellular_component owl:Class
CL:0000101 biolink:NamedThing got7fsn_ti owl:Class
GO:0052547 biolink:NamedThing regulation of peptidase activity Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. got7fsn_ti peptidase regulator activity biological_process owl:Class
GO:0005826 biolink:NamedThing actomyosin contractile ring A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis. got7fsn_ti constriction ring|CAR|contractile actomyosin ring|cytokinetic ring|actomyosin ring GO:0030480 cellular_component owl:Class
GO:0032153 biolink:NamedThing cell division site The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. got7fsn_ti cell division plane Note that this term refers to the future site of division in a cell that has not yet divided. cellular_component owl:Class
GO:0061456 biolink:NamedThing mesenchymal stem cell migration involved in uteric bud morphogenesis The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti dph 2012-08-22T17:19:22Z biological_process owl:Class
GO:0060675 biolink:NamedThing ureteric bud morphogenesis The process in which the ureteric bud is generated and organized. got7fsn_ti dph 2009-06-02T01:31:41Z biological_process owl:Class
GO:0090628 biolink:NamedThing plant epidermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into a plant epidermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti tb 2015-02-06T17:32:21Z biological_process owl:Class
GO:0015295 biolink:NamedThing solute:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). got7fsn_ti heavy metal ion:hydrogen symporter activity|low affinity metal ion uptake transporter activity|proline/glycine/betaine:hydrogen/sodium symporter activity|L-idonate/D-gluconate:hydrogen symporter activity|high affinity metal ion uptake transporter activity|solute:hydrogen symporter activity molecular_function owl:Class
GO:0070470 biolink:NamedThing plasma membrane respirasome A respiratory chain located in the plasma membrane of a cell; made up of the protein complexes that form the electron transport system (the respiratory chain), associated with the plasma membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. got7fsn_ti plasma membrane electron transport chain|plasma membrane respiratory chain https://github.com/geneontology/go-ontology/issues/12846 cellular_component owl:Class
GO:0030122 biolink:NamedThing AP-2 adaptor complex A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). got7fsn_ti HA2 clathrin adaptor|HA2 cellular_component owl:Class
GO:0030132 biolink:NamedThing clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. got7fsn_ti cellular_component owl:Class
GO:0005308 biolink:NamedThing creatine transmembrane transporter activity Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. got7fsn_ti molecular_function owl:Class
GO:0015881 biolink:NamedThing creatine transmembrane transport The directed movement of creatine across a membrane. got7fsn_ti creatine transport pr 2013-12-20T11:01:18Z GO:1902598 biological_process owl:Class
GO:0009677 biolink:NamedThing double fertilization forming two zygotes Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis. got7fsn_ti biological_process owl:Class
NCBITaxon:58022 biolink:NamedThing got7fsn_ti owl:Class
GO:0051395 biolink:NamedThing negative regulation of nerve growth factor receptor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor. got7fsn_ti negative regulation of NGF receptor activity|down-regulation of nerve growth factor receptor activity|inhibition of nerve growth factor receptor activity|downregulation of nerve growth factor receptor activity|down regulation of nerve growth factor receptor activity biological_process owl:Class
GO:0009357 biolink:NamedThing protein-N(PI)-phosphohistidine-sugar phosphotransferase complex An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system. got7fsn_ti cellular_component owl:Class
GO:0061122 biolink:NamedThing positive regulation of positive chemotaxis to cAMP Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. got7fsn_ti dph 2010-05-17T08:25:55Z biological_process owl:Class
GO:0043327 biolink:NamedThing chemotaxis to cAMP The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP. got7fsn_ti chemotaxis to 3',5' cAMP|chemotaxis to adenosine 3',5'-cyclophosphate|chemotaxis to cyclic AMP|chemotaxis to 3',5'-cAMP biological_process owl:Class
GO:0051284 biolink:NamedThing positive regulation of sequestering of calcium ion Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. got7fsn_ti up-regulation of sequestering of calcium ion|stimulation of sequestering of calcium ion|positive regulation of sequestering of calcium ion (Ca2+)|positive regulation of calcium ion (Ca2+) storage|up regulation of sequestering of calcium ion|positive regulation of calcium ion (Ca2+) sequestering|positive regulation of sequestration of calcium ion (Ca2+)|positive regulation of calcium ion (Ca2+) retention|positive regulation of retention of calcium ion (Ca2+)|positive regulation of storage of calcium ion (Ca2+)|activation of sequestering of calcium ion|upregulation of sequestering of calcium ion|positive regulation of calcium ion (Ca2+) sequestration biological_process owl:Class
GO:0006434 biolink:NamedThing seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA. got7fsn_ti biological_process owl:Class
GO:0097056 biolink:NamedThing selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine. got7fsn_ti selenocysteinyl-tRNA(Sec) formation|selenocysteinyl-tRNA(Sec) anabolism|selenocysteinyl-tRNA(Sec) biosynthesis|selenocysteinyl-tRNA(Sec) synthesis pr 2011-05-25T05:33:19Z biological_process owl:Class
GO:0090103 biolink:NamedThing cochlea morphogenesis The process in which the cochlea is generated and organized. got7fsn_ti tb 2009-11-18T11:45:11Z biological_process owl:Class
GO:0090102 biolink:NamedThing cochlea development The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound. got7fsn_ti tb 2009-11-18T11:42:15Z biological_process owl:Class
GO:0007465 biolink:NamedThing R7 cell fate commitment The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium. got7fsn_ti biological_process owl:Class
GO:0043202 biolink:NamedThing lysosomal lumen The volume enclosed within the lysosomal membrane. got7fsn_ti cellular_component owl:Class
GO:0060898 biolink:NamedThing eye field cell fate commitment involved in camera-type eye formation The commitment of neurectodermal cells to cells of the eye field and their capacity to differentiate into eye field cells. Eye field cells are neurectodermal cells that will form the optic placode. got7fsn_ti dph 2009-08-13T02:10:58Z biological_process owl:Class
GO:0060897 biolink:NamedThing neural plate regionalization The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. got7fsn_ti dph 2009-08-13T02:09:04Z biological_process owl:Class
GO:0035703 biolink:NamedThing monocyte migration into blood stream The movement of a monocyte from the bone marrow to the blood stream. got7fsn_ti release of monocytes into circulation bf 2011-03-02T11:37:54Z biological_process owl:Class
CL:0000576 biolink:NamedThing got7fsn_ti owl:Class
GO:0140537 biolink:NamedThing transcription regulator activator activity A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16132 Usage guidance: transcription regulator activators bind to a transcription regulator to allow it to reach the chromatin or to contact other transcriptional regulators. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001216 ; DNA-binding transcription activator activity or GO:0003713; transcription coactivator activity; those activities respectively bind DNA themselves or positively regulate a transcription regulator when it is located at the chromatin. pg 2020-11-03T14:04:59Z molecular_function owl:Class
GO:0010468 biolink:NamedThing regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. got7fsn_ti regulation of protein expression|regulation of gene product expression This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. Wikipedia:Regulation_of_gene_expression biological_process owl:Class
GO:0097743 biolink:NamedThing de novo centriole assembly via blepharoplast A de novo centriole assembly process observed in multi-ciliated sperm cells of some primitive land plants, and where centrioles are formed from a blepharoplast, ultimately giving rise to multiple cilia on the sperm surface. got7fsn_ti multiciliation|multiciliogenesis pr 2016-10-19T15:18:34Z biological_process owl:Class
NCBITaxon:35493 biolink:NamedThing got7fsn_ti owl:Class
GO:0030155 biolink:NamedThing regulation of cell adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. got7fsn_ti cell adhesion receptor regulator activity biological_process owl:Class
GO:0001188 biolink:NamedThing RNA polymerase I preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter. got7fsn_ti RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript|RNA polymerase I transcriptional preinitiation complex assembly|RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript krc 2011-08-24T04:16:28Z GO:0001189 biological_process owl:Class
GO:0070209 biolink:NamedThing ASTRA complex A protein complex that is part of the chromatin remodeling machinery; the acronym stands for ASsembly of Tel, Rvb and Atm-like kinase. In Saccharomyces cerevisiae this complex includes Rvb1p, Rvb2p, Tra1p, Tel2p, Asa1p, Ttilp and Tti2p. got7fsn_ti cellular_component owl:Class
GO:0003193 biolink:NamedThing pulmonary valve formation The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti dph 2009-10-08T01:11:20Z biological_process owl:Class
GO:0003184 biolink:NamedThing pulmonary valve morphogenesis The process in which the structure of the pulmonary valve is generated and organized. got7fsn_ti dph 2009-10-08T12:03:35Z biological_process owl:Class
GO:1990957 biolink:NamedThing NPHP complex A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways. got7fsn_ti NPHP module Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme. pr 2016-06-06T10:59:45Z cellular_component owl:Class
GO:0015651 biolink:NamedThing quaternary ammonium group transmembrane transporter activity Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. got7fsn_ti quaternary amine transmembrane transporter activity|quaternary ammonium compound transporter activity GO:0015202 molecular_function owl:Class
GO:0015697 biolink:NamedThing quaternary ammonium group transport The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. got7fsn_ti quaternary amine transport|quaternary ammonium compound transport GO:0015845 biological_process owl:Class
GO:0071019 biolink:NamedThing U12-type post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U12, U5 and U6atac snRNPs. got7fsn_ti AT-AC post-mRNA release spliceosomal complex|mammalian U12-type spliceosomal complex I|minor post-mRNA release spliceosomal complex mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0005691 biolink:NamedThing U6atac snRNP A ribonucleoprotein complex that contains small nuclear RNA U6atac, the Lsm2-8 heptameric ring complex, as well as several proteins that are unique to the U6atac snRNP, most of which remain associated with the U6atac snRNA both while the U6atac snRNP is free or assembled into the U4atac/U6atac snRNP or into a series of spliceosomal complexes. got7fsn_ti snRNP U6atac cellular_component owl:Class
GO:0021849 biolink:NamedThing neuroblast division in subventricular zone The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially. got7fsn_ti biological_process owl:Class
GO:0060285 biolink:NamedThing cilium-dependent cell motility Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. got7fsn_ti ciliary cell motility|cilium cell motility|microtubule-based flagellar cell motility Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent. GO:0071974 biological_process owl:Class
GO:0120020 biolink:NamedThing cholesterol transfer activity Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti cholesterol carrier activity|intermembrane cholesterol transfer activity|cholesterol transporter activity https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-17T04:46:12Z GO:0017127 Reactome:R-HSA-266082|Reactome:R-HSA-8951850|Reactome:R-HSA-5682111|Reactome:R-HSA-1454928|Reactome:R-HSA-216723|Reactome:R-HSA-265443|Reactome:R-HSA-265545 molecular_function owl:Class
GO:0015918 biolink:NamedThing sterol transport The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. got7fsn_ti biological_process owl:Class
GO:0019812 biolink:NamedThing type I site-specific deoxyribonuclease complex A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell. got7fsn_ti type I restriction enzyme complex cellular_component owl:Class
GO:0072062 biolink:NamedThing proximal convoluted tubule segment 1 cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the S1 cells of the kidney as it progresses from its formation to the mature state. got7fsn_ti S1 cell differentiation mah 2010-01-25T04:11:17Z biological_process owl:Class
GO:0072031 biolink:NamedThing proximal convoluted tubule segment 1 development The process whose specific outcome is the progression of the S1 portion of the proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the proximal convoluted tubule and is responsible for avid reabsorption of water and solutes. got7fsn_ti S1 development mah 2010-01-25T02:55:57Z biological_process owl:Class
GO:0002142 biolink:NamedThing stereocilia ankle link complex A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin. got7fsn_ti hjd 2009-05-06T10:33:57Z cellular_component owl:Class
GO:0002141 biolink:NamedThing stereocilia ankle link A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia. got7fsn_ti hjd 2009-05-06T10:31:56Z cellular_component owl:Class
GO:0086004 biolink:NamedThing regulation of cardiac muscle cell contraction Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction. got7fsn_ti tb 2011-11-10T07:49:10Z biological_process owl:Class
GO:1902940 biolink:NamedThing positive regulation of intracellular calcium activated chloride channel activity Any process that activates or increases the frequency, rate or extent of intracellular calcium activated chloride channel activity. got7fsn_ti up regulation of intracellular calcium activated chloride channel activity|activation of intracellular calcium activated chloride channel activity|up-regulation of intracellular calcium activated chloride channel activity|upregulation of intracellular calcium activated chloride channel activity als 2014-04-28T08:49:20Z biological_process owl:Class
GO:0098661 biolink:NamedThing inorganic anion transmembrane transport The process in which an inorganic anion is transported across a membrane. got7fsn_ti transmembrane inorganic anion transport|inorganic anion membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. biological_process owl:Class
GO:0035658 biolink:NamedThing Mon1-Ccz1 complex A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p. got7fsn_ti bf 2011-01-28T11:31:20Z cellular_component owl:Class
GO:0097416 biolink:NamedThing Lewy body-like hyaline inclusion Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments. got7fsn_ti LBHI pr 2012-11-06T16:46:15Z NIF_Subcellular:nlx_subcell_20090105 cellular_component owl:Class
CL:0000540 biolink:NamedThing got7fsn_ti owl:Class
CL:0000025 biolink:NamedThing got7fsn_ti owl:Class
GO:0061605 biolink:NamedThing molybdopterin-synthase adenylyltransferase activity Catalysis of the reaction: ATP [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly = diphosphate [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP. got7fsn_ti dph 2014-02-11T12:01:32Z EC:2.7.7.80|RHEA:43616 molecular_function owl:Class
GO:0019045 biolink:NamedThing latent virus replication Any process required for latent viral replication in a cell. got7fsn_ti biological_process owl:Class
GO:0019042 biolink:NamedThing viral latency The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate. got7fsn_ti viral dormancy|latent virus infection|phage lysogeny GO:0075710|GO:0030069 biological_process owl:Class
GO:0072371 biolink:NamedThing histone kinase activity (H2A-S121 specific) Catalysis of the transfer of a phosphate group to the serine-121 residue of the N-terminal tail of histone H2A. got7fsn_ti histone-serine kinase activity (H2A-S121 specific)|histone serine kinase activity (H2A-S121 specific) mah 2010-11-16T03:42:59Z molecular_function owl:Class
GO:0072370 biolink:NamedThing histone H2A-S121 phosphorylation The modification of histone H2A by the addition of an phosphate group to a serine residue at position 121 of the histone. got7fsn_ti histone H2AS121 phosphorylation|histone H2A phosphorylation at S121 mah 2010-11-16T03:42:52Z biological_process owl:Class
GO:0045271 biolink:NamedThing respiratory chain complex I Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex. got7fsn_ti NADH dehydrogenase complex (ubiquinone)|NADH dehydrogenase (ubiquinone) complex|electron transport complex I|NADH-Q oxidoreductase complex Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (ubiquinone) activity ; GO:0008137'. GO:0045279 cellular_component owl:Class
GO:0015231 biolink:NamedThing 5-formyltetrahydrofolate transmembrane transporter activity Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other. got7fsn_ti 5-formyltetrahydrofolate transporter activity molecular_function owl:Class
GO:0015885 biolink:NamedThing 5-formyltetrahydrofolate transport The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0015137 biolink:NamedThing citrate transmembrane transporter activity Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other. got7fsn_ti tricarboxylate transport protein Reactome:R-HSA-433104|TC:2.A.29.7.2 molecular_function owl:Class
GO:0015746 biolink:NamedThing citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1990675 biolink:NamedThing Golgi medial cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex. got7fsn_ti medial-Golgi cisterna membrane bhm 2015-03-02T11:50:29Z cellular_component owl:Class
GO:0005797 biolink:NamedThing Golgi medial cisterna The middle Golgi cisterna (or cisternae). got7fsn_ti cellular_component owl:Class
GO:0010063 biolink:NamedThing positive regulation of trichoblast fate specification Any process that induces or promotes trichoblast fate specification. got7fsn_ti up regulation of trichoblast fate|upregulation of trichoblast fate|stimulation of trichoblast fate|activation of trichoblast fate|up-regulation of trichoblast fate biological_process owl:Class
GO:0006412 biolink:NamedThing translation The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. got7fsn_ti protein biosynthetic process|protein anabolism|protein formation|protein synthesis|protein translation|protein biosynthesis GO:0043037|GO:0006416|GO:0006453 Wikipedia:Translation_(genetics) biological_process owl:Class
GO:0045755 biolink:NamedThing negative regulation of initiation of acetate catabolic process by acetate Any process that stops or prevents the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. got7fsn_ti downregulation of initiation of acetate catabolic process by acetate|negative regulation of initiation of acetate breakdown by acetate|down regulation of initiation of acetate catabolic process by acetate|inhibition of initiation of acetate catabolic process by acetate|down-regulation of initiation of acetate catabolic process by acetate|negative regulation of initiation of acetate degradation by acetate biological_process owl:Class
GO:0062074 biolink:NamedThing pollen aperture An area where exine is reduced or absent, in the pollen wall. got7fsn_ti dph 2018-09-19T19:19:58Z cellular_component owl:Class
GO:0021684 biolink:NamedThing cerebellar granular layer formation The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. got7fsn_ti biological_process owl:Class
NCBITaxon:Union_0000031 biolink:NamedThing got7fsn_ti owl:Class
GO:1904625 biolink:NamedThing negative regulation of glycine secretion, neurotransmission Any process that stops, prevents or reduces the frequency, rate or extent of glycine secretion, neurotransmission. got7fsn_ti down-regulation of glycine secretion, neurotransmission|downregulation of glycine secretion, neurotransmission|inhibition of glycine secretion, neurotransmission|down regulation of glycine secretion, neurotransmission hjd 2015-08-27T20:03:44Z biological_process owl:Class
GO:1905937 biolink:NamedThing negative regulation of germ cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation. got7fsn_ti down-regulation of germ cell proliferation|down regulation of germ cell proliferation|inhibition of germ cell proliferation|downregulation of germ cell proliferation hbye 2017-02-09T14:51:41Z biological_process owl:Class
GO:0016282 biolink:NamedThing eukaryotic 43S preinitiation complex A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA. got7fsn_ti eukaryotic 43S pre-initiation complex cellular_component owl:Class
GO:0060017 biolink:NamedThing parathyroid gland development The process whose specific outcome is the progression of the parathyroid gland over time, from its formation to the mature structure. The parathyroid gland is an organ specialised for secretion of parathyroid hormone. got7fsn_ti biological_process owl:Class
GO:0097047 biolink:NamedThing DNA replication termination region A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks. got7fsn_ti TER pr 2011-05-03T03:38:40Z cellular_component owl:Class
GO:0010330 biolink:NamedThing cellulose synthase complex A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall. got7fsn_ti CESA complex cellular_component owl:Class
GO:0042640 biolink:NamedThing anagen The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair. got7fsn_ti hair growth Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0043599 biolink:NamedThing nuclear DNA replication factor C complex A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species. got7fsn_ti nuclear RFC cellular_component owl:Class
GO:0038155 biolink:NamedThing interleukin-23-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-23-mediated signaling pathway|interleukin-23-mediated signalling pathway bf 2012-05-11T11:49:56Z biological_process owl:Class
GO:0071140 biolink:NamedThing resolution of mitotic recombination intermediates The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged. got7fsn_ti mah 2009-11-16T12:06:05Z biological_process owl:Class
GO:0006312 biolink:NamedThing mitotic recombination The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles. got7fsn_ti Wikipedia:Mitotic_crossover biological_process owl:Class
GO:0110067 biolink:NamedThing ammonium transmembrane transporter complex High affinity ammonium transporter complex that enables the transfer of ammonium from one side of a membrane to the other. got7fsn_ti AMT1 complex kmv 2017-11-20T15:21:10Z cellular_component owl:Class
GO:0032178 biolink:NamedThing medial membrane band A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum. got7fsn_ti sterol-rich membrane band cellular_component owl:Class
GO:0048657 biolink:NamedThing anther wall tapetum cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an anther cell wall tapetum cell. The tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. got7fsn_ti tapetal cell differentiation biological_process owl:Class
GO:0048656 biolink:NamedThing anther wall tapetum formation The process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature. got7fsn_ti tapetal layer formation|tapetum formation biological_process owl:Class
GO:0002499 biolink:NamedThing proteolysis within endosome associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation. got7fsn_ti endosomal proteolysis associated with antigen processing and presentation biological_process owl:Class
GO:0035804 biolink:NamedThing structural constituent of egg coat The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. got7fsn_ti structural constituent of vitelline envelope|structural constituent of zona pellucida bf 2011-04-19T01:56:06Z molecular_function owl:Class
GO:0010706 biolink:NamedThing ganglioside biosynthetic process via lactosylceramide The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. got7fsn_ti ganglioside biosynthesis via lactosylceramide biosynthesis|lactosylceramide biosynthesis leading to ganglioside|biosynthesis of lactosylceramide precursor to ganglioside|lactosylceramide biosynthetic process leading to ganglioside biological_process owl:Class
GO:0001572 biolink:NamedThing lactosylceramide biosynthetic process The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides. got7fsn_ti lactosylceramide formation|lactosylceramide synthesis|lactosylceramide anabolism|lactosylceramide biosynthesis biological_process owl:Class
GO:0031911 biolink:NamedThing cytoproct Stable, specialized structure for extrusion of waste by the cell into the surrounding medium. got7fsn_ti cellular_component owl:Class
GO:0010110 biolink:NamedThing regulation of photosynthesis, dark reaction Any process that modulates the frequency, rate or extent of photosynthesis dark reaction. got7fsn_ti biological_process owl:Class
GO:0004994 biolink:NamedThing somatostatin receptor activity Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). got7fsn_ti SST receptor activity|SRIF receptor activity|GHIH receptor activity|growth hormone-inhibiting hormone receptor activity|somatotrophin release inhibiting factor receptor activity molecular_function owl:Class
GO:0072025 biolink:NamedThing distal convoluted tubule development The process whose specific outcome is the progression of the distal convoluted tubule over time, from its formation to the mature structure. The distal convoluted tubule is the first segment of the nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. got7fsn_ti mah 2010-01-25T02:40:45Z biological_process owl:Class
GO:0140246 biolink:NamedThing protein catabolic process at synapse The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. got7fsn_ti https://github.com/geneontology/synapse/issues/210 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T10:12:51Z biological_process owl:Class
GO:0045269 biolink:NamedThing proton-transporting ATP synthase, central stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis. got7fsn_ti hydrogen-transporting ATP synthase, central stalk cellular_component owl:Class
GO:0030168 biolink:NamedThing platelet activation A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. got7fsn_ti blood coagulation, platelet activation biological_process owl:Class
GO:0001055 biolink:NamedThing RNA polymerase II activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter krc 2010-09-23T03:44:23Z Reactome:R-HSA-6814549|Reactome:R-HSA-6814559 molecular_function owl:Class
GO:0015489 biolink:NamedThing putrescine transmembrane transporter activity Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. got7fsn_ti molecular_function owl:Class
GO:0015847 biolink:NamedThing putrescine transport The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. got7fsn_ti biological_process owl:Class
GO:0050970 biolink:NamedThing detection of electrical stimulus involved in magnetoreception The series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field. got7fsn_ti magnetoreception, sensory detection of electrical stimulus|magnetoreception, detection of electrical stimulus|sensory transduction of electrical stimulus during magnetoreception|magnetoception, sensory transduction of electrical stimulus|magnetoreception, sensory transduction of electrical stimulus|sensory detection of electrical stimulus during magnetoreception|detection of electrical stimulus during magnetoreception biological_process owl:Class
GO:0034994 biolink:NamedThing microtubule organizing center attachment site organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches. got7fsn_ti MTOC attachment site organization|MAS organization|microtubule organising centre attachment site organisation biological_process owl:Class
GO:0048137 biolink:NamedThing spermatocyte division The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids. got7fsn_ti spermatocyte cell division biological_process owl:Class
GO:0042777 biolink:NamedThing plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. got7fsn_ti ATP synthesis coupled proton transport biological_process owl:Class
GO:0060847 biolink:NamedThing endothelial cell fate specification The process involved in the specification of identity of an endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. got7fsn_ti dph 2009-08-12T11:00:04Z biological_process owl:Class
GO:0060839 biolink:NamedThing endothelial cell fate commitment The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell. got7fsn_ti dph 2009-08-11T03:52:53Z biological_process owl:Class
GO:0097541 biolink:NamedThing axonemal basal plate Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure. got7fsn_ti axoneme basal plate|basal plate pr 2013-12-12T11:10:39Z cellular_component owl:Class
GO:0060659 biolink:NamedThing nipple sheath formation The developmental process pertaining to the initial formation of the nipple sheath from the unspecified epidermis. This process begins with a circular ingrowth of the epidermis around the region of the mammary sprout. It ends before the region begins to elevate. got7fsn_ti dph 2009-05-29T10:48:39Z biological_process owl:Class
GO:1990325 biolink:NamedThing collagen type XXVII trimer A collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone. got7fsn_ti bhm 2014-03-16T23:13:15Z cellular_component owl:Class
GO:0007432 biolink:NamedThing salivary gland boundary specification Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. got7fsn_ti salivary gland determination biological_process owl:Class
GO:0007431 biolink:NamedThing salivary gland development The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity. got7fsn_ti biological_process owl:Class
GO:0055038 biolink:NamedThing recycling endosome membrane The lipid bilayer surrounding a recycling endosome. got7fsn_ti cellular_component owl:Class
GO:0055037 biolink:NamedThing recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. got7fsn_ti endosomal recycling compartment|ERC|endosome recycling compartment cellular_component owl:Class
GO:0015988 biolink:NamedThing energy coupled proton transmembrane transport, against electrochemical gradient The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport. got7fsn_ti biological_process owl:Class
CHEBI:24636 biolink:NamedThing got7fsn_ti owl:Class
GO:0070920 biolink:NamedThing regulation of production of small RNA involved in gene silencing by RNA Any process that modulates the frequency, rate or extent of the production of small RNA involved in gene silencing by RNA. got7fsn_ti regulation of gene silencing by RNA, production of guide RNA|regulation of gene silencing by RNA, production of small RNA mah 2009-09-11T03:41:59Z biological_process owl:Class
GO:0018989 biolink:NamedThing apolysis The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells. got7fsn_ti Wikipedia:Apolysis biological_process owl:Class
GO:1903774 biolink:NamedThing positive regulation of viral budding via host ESCRT complex Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex. got7fsn_ti positive regulation of viral budding through the ESCRT machinery|upregulation of viral budding through the ESCRT machinery|up-regulation of viral budding through the ESCRT machinery|up regulation of viral budding through the ESCRT machinery|up regulation of viral budding via host ESCRT complex|upregulation of viral budding via host ESCRT complex|activation of viral budding through the ESCRT machinery|activation of viral budding via host ESCRT complex|up-regulation of viral budding via host ESCRT complex als 2015-01-06T16:21:02Z biological_process owl:Class
GO:1990220 biolink:NamedThing GroEL-GroES complex Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins. got7fsn_ti bacterial chaperonin complex|bacterial chaperonin ATPase complex bhm 2013-10-11T09:20:01Z cellular_component owl:Class
GO:1900245 biolink:NamedThing positive regulation of MDA-5 signaling pathway Any process that activates or increases the frequency, rate or extent of MDA-5 signaling pathway. got7fsn_ti activation of melanoma differentiation-associated gene 5 signaling pathway|positive regulation of MDA-5 signalling pathway|up-regulation of IFIH1 signaling pathway|up regulation of IFIH1 signaling pathway|upregulation of IFIH1 signaling pathway|up-regulation of MDA5 signaling pathway|positive regulation of IFIH1 signaling pathway|up-regulation of MDA-5 signaling pathway|up regulation of MDA-5 signaling pathway|up-regulation of melanoma differentiation-associated gene 5 signaling pathway|positive regulation of MDA5 signaling pathway|upregulation of MDA5 signaling pathway|activation of MDA5 signaling pathway|up regulation of MDA5 signaling pathway|activation of MDA-5 signaling pathway|activation of IFIH1 signaling pathway|positive regulation of melanoma differentiation-associated gene 5 signaling pathway|upregulation of melanoma differentiation-associated gene 5 signaling pathway|up regulation of melanoma differentiation-associated gene 5 signaling pathway|upregulation of MDA-5 signaling pathway ss 2012-04-02T10:55:38Z biological_process owl:Class
GO:0048392 biolink:NamedThing intermediate mesodermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an intermediate mesoderm cell. got7fsn_ti intermediate mesoderm cell differentiation biological_process owl:Class
GO:0061823 biolink:NamedThing ring centriole A ring-like structure observed at the base of the ciliary cap of insect spermatids. This structure may anchor the axoneme to the ciliary cap membrane and/or act as a diffusion barrier, proposed to be analogous to the annulus of mammalian sperm flagellum. got7fsn_ti dph 2017-01-14T14:18:29Z cellular_component owl:Class
GO:0000089 biolink:NamedThing mitotic metaphase The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0000087 biolink:NamedThing mitotic M phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle. got7fsn_ti M-phase of mitotic cell cycle|M phase of mitotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0120124 biolink:NamedThing membrane fusion priming complex A protein complex that primes vacuolar or vesicular membranes for fusion with other intracellular membranes, by promoting the dissociation of cis-SNARE complexes. got7fsn_ti GATE-16 complex|LMA1 complex krc 2018-02-06T22:22:47Z cellular_component owl:Class
GO:0042144 biolink:NamedThing vacuole fusion, non-autophagic The fusion of two vacuole membranes to form a single vacuole. got7fsn_ti homotypic vacuole fusion (non-autophagic)|homotypic vacuole fusion|vacuole fusion (non-autophagic)|homotypic vacuole fusion, non-autophagic GO:0042145 biological_process owl:Class
GO:0034400 biolink:NamedThing gerontoplast A plastid found in senescing, formerly green tissues that is derived from a chloroplast that undergoes an organized developmental program of senescence. got7fsn_ti cellular_component owl:Class
GO:0005833 biolink:NamedThing hemoglobin complex An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group. got7fsn_ti haemoglobin complex cellular_component owl:Class
GO:1902964 biolink:NamedThing positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Any process that activates or increases the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. got7fsn_ti positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|up-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|positive regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|activation of metalloendoprotease activity involved in APP catabolism|upregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|up regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|up-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|up-regulation of metalloendopeptidase activity involved in APP catabolic process|positive regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|up-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|up regulation of metalloendoprotease activity involved in APP catabolic process|activation of metalloendopeptidase activity involved in APP catabolic process|up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|activation of metalloendoprotease activity involved in amyloid precursor protein catabolism|activation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|activation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|up regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|activation of metalloendoprotease activity involved in amyloid precursor protein breakdown|up-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|up-regulation of metalloendoprotease activity involved in APP catabolic process|upregulation of metalloendoprotease activity involved in APP catabolic process|up regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|up regulation of metalloendoproteinase activity involved in APP catabolism|upregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|up regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|positive regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|positive regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|up-regulation of metalloendopeptidase activity involved in APP catabolism|up-regulation of metalloendoprotease activity involved in APP catabolism|positive regulation of metalloendoproteinase activity involved in APP catabolic process|positive regulation of metalloendoprotease activity involved in APP catabolism|upregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|up-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|positive regulation of metalloendoproteinase activity involved in APP catabolism|upregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|positive regulation of metalloendopeptidase activity involved in APP catabolism|up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|up regulation of metalloendoprotease activity involved in APP catabolism|up-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|activation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|activation of metalloendopeptidase activity involved in APP catabolism|upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|upregulation of metalloendopeptidase activity involved in APP catabolism|upregulation of metalloendoproteinase activity involved in APP catabolic process|activation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|upregulation of metalloendoprotease activity involved in amyloid precursor protein degradation|up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|activation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|activation of metalloendoprotease activity involved in amyloid precursor protein degradation|positive regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|up-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|upregulation of metalloendopeptidase activity involved in APP catabolic process|positive regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|up-regulation of metalloendoproteinase activity involved in APP catabolism|up regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|upregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|activation of metalloendopeptidase activity involved in amyloid precursor protein degradation|up regulation of metalloendopeptidase activity involved in APP catabolism|up-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|positive regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|activation of metalloendoproteinase activity involved in amyloid precursor protein degradation|positive regulation of metalloendoprotease activity involved in APP catabolic process|upregulation of metalloendoproteinase activity involved in APP catabolism|activation of metalloendoprotease activity involved in APP catabolic process|up regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|upregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|upregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|positive regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|activation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|up regulation of metalloendopeptidase activity involved in APP catabolic process|up regulation of metalloendoproteinase activity involved in APP catabolic process|up-regulation of metalloendoproteinase activity involved in APP catabolic process|positive regulation of metalloendopeptidase activity involved in APP catabolic process|upregulation of metalloendoprotease activity involved in APP catabolism|up-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|upregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|up regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|up regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|activation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|up regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|activation of metalloendoproteinase activity involved in APP catabolic process|activation of metalloendoproteinase activity involved in APP catabolism sjp 2014-05-06T09:12:11Z biological_process owl:Class
GO:0042987 biolink:NamedThing amyloid precursor protein catabolic process The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of amyloid-beta, a glycoprotein associated with Alzheimer's disease. got7fsn_ti amyloid precursor protein catabolism|APP catabolic process|amyloid precursor protein degradation|amyloid precursor protein breakdown|APP catabolism biological_process owl:Class
GO:0032784 biolink:NamedThing regulation of DNA-templated transcription, elongation Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. got7fsn_ti transcription elongation regulator activity|regulation of RNA elongation|regulation of DNA-dependent transcription, elongation|regulation of transcriptional elongation|regulation of transcription elongation, DNA-dependent biological_process owl:Class
GO:0032450 biolink:NamedThing maltose alpha-glucosidase activity Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose. got7fsn_ti maltase activity EC:3.2.1.20|MetaCyc:RXN-2141 molecular_function owl:Class
GO:0000023 biolink:NamedThing maltose metabolic process The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch. got7fsn_ti malt sugar metabolism|maltose metabolism|malt sugar metabolic process biological_process owl:Class
GO:0120099 biolink:NamedThing procentriole replication complex A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates. got7fsn_ti krc 2017-09-28T21:41:34Z cellular_component owl:Class
GO:1990674 biolink:NamedThing Golgi cis cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex. got7fsn_ti cis-Golgi cisterna membrane bhm 2015-03-02T11:48:00Z cellular_component owl:Class
GO:0031095 biolink:NamedThing platelet dense tubular network membrane The lipid bilayer surrounding the platelet dense tubular network. got7fsn_ti cellular_component owl:Class
GO:0090393 biolink:NamedThing sepal giant cell development The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti sepal giant cell formation tb 2010-12-14T04:44:34Z biological_process owl:Class
GO:0090392 biolink:NamedThing sepal giant cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C. got7fsn_ti tb 2010-12-14T04:38:06Z biological_process owl:Class
GO:0005337 biolink:NamedThing nucleoside transmembrane transporter activity Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. got7fsn_ti intracellular nucleoside transmembrane transporter activity Reactome:R-HSA-109536|Reactome:R-HSA-109527|Reactome:R-HSA-109534|Reactome:R-HSA-5628807|RHEA:27318|Reactome:R-HSA-109529|Reactome:R-HSA-727768|Reactome:R-HSA-727767|Reactome:R-HSA-727749|Reactome:R-HSA-727740 molecular_function owl:Class
GO:1901642 biolink:NamedThing nucleoside transmembrane transport The directed movement of nucleoside across a membrane. got7fsn_ti nucleoside membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. pr 2012-11-16T13:32:01Z biological_process owl:Class
GO:0047145 biolink:NamedThing demethylsterigmatocystin 6-O-methyltransferase activity Catalysis of the reaction: 6-demethylsterigmatocystin + S-adenosyl-L-methionine = sterigmatocystin + S-adenosyl-homocysteine. got7fsn_ti S-adenosyl-L-methionine:6-demethylsterigmatocystin 6-O-methyltransferase activity|O-methyltransferase I|demethylsterigmatocystin methyltransferase activity RHEA:11504|EC:2.1.1.109|MetaCyc:2.1.1.109-RXN molecular_function owl:Class
GO:0097595 biolink:NamedThing ventral disc crossbridge Structure horizontally linking adjacent microribbons of the ventral disc in Giardia species (trophozoite stage). The composition of crossbridges is not fully known yet. got7fsn_ti ventral disk crossbridge|crossbridge Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-04-03T11:23:33Z cellular_component owl:Class
GO:0009842 biolink:NamedThing cyanelle A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid. got7fsn_ti muroplast|cyanoplast cellular_component owl:Class
GO:0044306 biolink:NamedThing neuron projection terminus The specialized, terminal region of a neuron projection such as an axon or a dendrite. got7fsn_ti neuron projection terminal|nerve terminal|neuron terminal specialization jl 2010-02-05T02:44:04Z cellular_component owl:Class
GO:0030902 biolink:NamedThing hindbrain development The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium). got7fsn_ti rhombencephalon development biological_process owl:Class
GO:0009515 biolink:NamedThing granal stacked thylakoid Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II. got7fsn_ti chloroplast stacked thylakoid cellular_component owl:Class
GO:0034592 biolink:NamedThing synaptic vesicle lumen The volume enclosed by the synaptic vesicle membrane. got7fsn_ti cellular_component owl:Class
GO:0098028 biolink:NamedThing virus tail, shaft The tube of the non-contractile tails of some viruses. got7fsn_ti bacteriophage tail shaft This term applies in particular to the Siphoviridae bacteriophages, where the shaft is the channel for DNA translocation into the host cytoplasm. bm 2012-07-19T14:24:28Z cellular_component owl:Class
GO:0035271 biolink:NamedThing ring gland development Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones. got7fsn_ti See also the fly_anatomy.ontology terms 'ring gland ; FBbt:00001722, 'prothoracic gland ; FBbt:00001724', 'corpus allatum ; FBbt:00005800' and 'corpus cardiacum ; FBbt:00005799. biological_process owl:Class
GO:0032068 biolink:NamedThing type IV site-specific deoxyribonuclease complex A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation. got7fsn_ti type IV restriction enzyme complex cellular_component owl:Class
GO:1905661 biolink:NamedThing regulation of telomerase RNA reverse transcriptase activity Any process that modulates the frequency, rate or extent of telomerase RNA reverse transcriptase activity. got7fsn_ti regulation of telomerase, catalyst nc 2016-11-09T16:55:20Z biological_process owl:Class
GO:0003720 biolink:NamedThing telomerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. got7fsn_ti Reactome:R-HSA-163090|Reactome:R-HSA-164617 molecular_function owl:Class
GO:0000919 biolink:NamedThing cell plate assembly The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast. got7fsn_ti cell plate formation biological_process owl:Class
GO:0000911 biolink:NamedThing cytokinesis by cell plate formation The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana. got7fsn_ti biological_process owl:Class
GO:0098700 biolink:NamedThing neurotransmitter loading into synaptic vesicle The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps. got7fsn_ti synaptic vesicle neurotransmitter loading|neurotransmitter uptake into synaptic vesicle|neurotransmitter import into synaptic vesicle biological_process owl:Class
GO:1990691 biolink:NamedThing cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport. got7fsn_ti cis-Golgi-derived vesicle fusion with medial-Golgi cisterna membrane bhm 2015-03-12T09:51:01Z biological_process owl:Class
GO:0048219 biolink:NamedThing inter-Golgi cisterna vesicle-mediated transport The directed movement of substances from one Golgi cisterna to another, mediated by small transport vesicles. got7fsn_ti inter-Golgi cisterna transport biological_process owl:Class
GO:0072493 biolink:NamedThing host cell endosome lumen The volume enclosed by the membranes of the host cell endosome. got7fsn_ti host endosome lumen mah 2010-12-15T11:45:53Z cellular_component owl:Class
GO:0003328 biolink:NamedThing pancreatic D cell fate commitment The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin. got7fsn_ti dph 2009-11-02T08:33:36Z biological_process owl:Class
GO:0003311 biolink:NamedThing pancreatic D cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin. got7fsn_ti pancreatic delta cell differentiation dph 2009-10-26T09:30:27Z biological_process owl:Class
GO:0000712 biolink:NamedThing resolution of meiotic recombination intermediates The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged. got7fsn_ti resolution of meiotic joint molecules as recombinants biological_process owl:Class
GO:2000635 biolink:NamedThing negative regulation of primary miRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing. got7fsn_ti negative regulation of primary microRNA processing|negative regulation of pri-miRNA processing dph 2011-04-18T03:50:53Z biological_process owl:Class
GO:0072239 biolink:NamedThing metanephric glomerulus vasculature development The biological process whose specific outcome is the progression of a metanephric glomerulus vasculature from an initial condition to its mature state. This process begins with the formation of the metanephric glomerulus vasculature and ends with the mature structure. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus. got7fsn_ti glomerulus capillary development mah 2010-03-18T03:50:29Z biological_process owl:Class
GO:0072224 biolink:NamedThing metanephric glomerulus development The progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or metanephros. got7fsn_ti metanephric glomerular development mah 2010-03-18T03:36:20Z biological_process owl:Class
GO:0005304 biolink:NamedThing L-valine transmembrane transporter activity Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid. got7fsn_ti valine/tyrosine/tryptophan permease activity|leucine/valine/isoleucine permease activity|L-valine transporter activity|leucine/isoleucine/valine porter activity|isoleucine/valine:sodium symporter activity molecular_function owl:Class
GO:1903785 biolink:NamedThing L-valine transmembrane transport The directed movement of L-valine across a membrane. got7fsn_ti al 2015-01-08T14:50:32Z biological_process owl:Class
GO:1901203 biolink:NamedThing positive regulation of extracellular matrix assembly Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly. got7fsn_ti activation of extracellular matrix assembly|up regulation of extracellular matrix assembly|upregulation of extracellular matrix assembly|up-regulation of extracellular matrix assembly rl 2012-07-27T04:04:32Z biological_process owl:Class
GO:0002492 biolink:NamedThing peptide antigen assembly with MHC class Ib protein complex The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti biological_process owl:Class
GO:0002398 biolink:NamedThing MHC class Ib protein complex assembly The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules. got7fsn_ti biological_process owl:Class
GO:0042012 biolink:NamedThing interleukin-16 receptor activity Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-16R|IL-16 receptor activity molecular_function owl:Class
GO:0042011 biolink:NamedThing interleukin-16 binding Binding to interleukin-16. got7fsn_ti IL-16 binding molecular_function owl:Class
GO:0042921 biolink:NamedThing glucocorticoid receptor signaling pathway Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor. got7fsn_ti glucocorticoid receptor signalling pathway biological_process owl:Class
GO:0007470 biolink:NamedThing prothoracic disc morphogenesis The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle. got7fsn_ti prothoracic disc metamorphosis biological_process owl:Class
GO:1903730 biolink:NamedThing regulation of phosphatidate phosphatase activity Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity. got7fsn_ti regulation of phosphatidic acid phosphatase activity|regulation of 3-sn-phosphatidate phosphohydrolase activity|regulation of acid phosphatidyl phosphatase activity|regulation of phosphatic acid phosphatase activity|regulation of phosphatidate phosphohydrolase activity|regulation of phosphatic acid phosphohydrolase activity Any process that modulates the frequency, rate or extent of phosphatidate phosphatase activity rn 2014-12-11T21:29:55Z biological_process owl:Class
GO:0010866 biolink:NamedThing regulation of triglyceride biosynthetic process Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. got7fsn_ti regulation of triacylglycerol biosynthetic process biological_process owl:Class
GO:0048528 biolink:NamedThing post-embryonic root development The process whose specific outcome is the progression of the post-embryonic root over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0043309 biolink:NamedThing regulation of eosinophil degranulation Any process that modulates the frequency, rate, or extent of eosinophil degranulation. got7fsn_ti regulation of eosinophil granule exocytosis biological_process owl:Class
GO:0061524 biolink:NamedThing central canal development The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord. got7fsn_ti dph 2013-04-20T08:18:31Z biological_process owl:Class
GO:0021510 biolink:NamedThing spinal cord development The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. got7fsn_ti biological_process owl:Class
GO:0043985 biolink:NamedThing histone H4-R3 methylation The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone. got7fsn_ti histone H4 R3 methylation|histone H4 methylation at R3|histone H4R3me biological_process owl:Class
GO:0007472 biolink:NamedThing wing disc morphogenesis The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura. got7fsn_ti wing disc metamorphosis biological_process owl:Class
GO:0070622 biolink:NamedThing UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex A protein complex that possesses UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity; the bovine complex contains disulfide-linked homodimers of 166- and 51-kDa subunits and two identical, noncovalently associated 56-kDa subunits. got7fsn_ti UDP-N-acetylglucosamine:lysosomal-enzyme N-acetylglucosamine-1-phosphotransferase complex|N-acetylglucosamine-1-phosphotransferase complex mah 2009-04-29T04:50:35Z cellular_component owl:Class
GO:0006120 biolink:NamedThing mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation. got7fsn_ti oxidative phosphorylation, NADH to ubiquinone|complex I (NADH to ubiquinone) biological_process owl:Class
GO:0042775 biolink:NamedThing mitochondrial ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane. got7fsn_ti mitochondrial electron transport|organelle ATP synthesis coupled electron transport biological_process owl:Class
GO:0060672 biolink:NamedThing epithelial cell morphogenesis involved in placental branching The change in form (cell shape and size) that occurs when a trophoblast cell elongates to contribute to the branching of the placenta. got7fsn_ti dph 2009-06-02T12:44:52Z biological_process owl:Class
GO:0060671 biolink:NamedThing epithelial cell differentiation involved in embryonic placenta development The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer. got7fsn_ti dph 2009-06-02T11:40:52Z biological_process owl:Class
GO:0016502 biolink:NamedThing nucleotide receptor activity Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. got7fsn_ti molecular_function owl:Class
GO:1900095 biolink:NamedThing regulation of dosage compensation by inactivation of X chromosome Any process that modulates the frequency, rate or extent of dosage compensation, by inactivation of X chromosome. got7fsn_ti regulation of Barr body formation|regulation of chromosome inactivation|regulation of X chromosome inactivation hjd 2012-02-14T07:29:45Z biological_process owl:Class
GO:0019236 biolink:NamedThing response to pheromone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus. got7fsn_ti pheromone response biological_process owl:Class
GO:0070782 biolink:NamedThing phosphatidylserine exposure on apoptotic cell surface A phospholipid scrambling process that results in the appearance of phosphatidylserine on the outer leaflet of the plasma membrane of an apoptotic cell, which acts as an 'eat-me' signal for engulfing cells. Phosphatidylserine is exposed on the apoptotic cell surface by a phospholipid scramblase activity. got7fsn_ti externalization of phosphatidylserine In normal cells, phosphatidylserine residues are found exclusively on the inner side of the cellular membrane. During apoptosis, phosphatidylserine is transported to the outer cell surface by scramblase proteins. This event acts as an "eat-me" signal for macrophages to dispose of the dying cell. When annotating to this term, curators should be aware of the following: 1) phosphatidylserine exposure on the cell surface can occur in circumstances other than apoptosis (for example, when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system, see PMID:21107324). Do not annotate to GO:0070782 unless phosphatidylserine exposure is shown to be part of an apoptotic event. 2) Caution should be applied when a study quotes annexin V assays. The annexin A5 protein binds to phosphatidylserine-containing membrane surfaces, which are usually only present on the inner leaflet of the membrane. However, in cells undergoing apoptosis, phosphatidylserine becomes exposed on the outer leaflet of the membrane. A positive annexin assay can therefore be linked to apoptotic death, but it shouldn't be confused with molecular events strictly involved in the process of phosphatidylserine exposure. mah 2009-07-02T02:41:44Z biological_process owl:Class
GO:0036302 biolink:NamedThing atrioventricular canal development The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle. got7fsn_ti bf 2012-08-08T09:55:37Z biological_process owl:Class
GO:0001702 biolink:NamedThing gastrulation with mouth forming second A gastrulation process in which the initial invagination becomes the anus and the mouth forms second. got7fsn_ti deuterostomic gastrulation GO:0010003|GO:0048276 biological_process owl:Class
NCBITaxon:33511 biolink:NamedThing got7fsn_ti owl:Class
GO:0039019 biolink:NamedThing pronephric nephron development The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros. got7fsn_ti bf 2010-07-02T10:10:20Z biological_process owl:Class
GO:0032119 biolink:NamedThing sequestering of zinc ion The process of binding or confining zinc ions such that they are separated from other components of a biological system. got7fsn_ti biological_process owl:Class
GO:1990963 biolink:NamedThing establishment of blood-retinal barrier Establishment of the barrier between the blood and the retina. The blood-retinal barrier is located at two levels, forming an outer barrier in the retinal pigment epithelium and an inner barrier in the endothelial membrane of the retinal vessels. Both these membranes have tight junctions of the 'nonleaky' type. got7fsn_ti establishment of blood-retina barrier|establishment of BRB sl 2016-06-07T21:17:55Z biological_process owl:Class
GO:0009840 biolink:NamedThing chloroplastic endopeptidase Clp complex A Clp endopeptidase complex located in the chloroplast. got7fsn_ti cellular_component owl:Class
GO:0060332 biolink:NamedThing positive regulation of response to interferon-gamma Any process that increases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. got7fsn_ti positive regulation of response to immune interferon|positive regulation of response to type II IFN|positive regulation of response to gamma-interferon|positive regulation of response to type II interferon biological_process owl:Class
GO:0099003 biolink:NamedThing vesicle-mediated transport in synapse Any vesicle-mediated transport that occurs in a synapse. got7fsn_ti biological_process owl:Class
GO:0002784 biolink:NamedThing regulation of antimicrobial peptide production Any process that modulates the frequency, rate, or extent of antimicrobial peptide production. got7fsn_ti biological_process owl:Class
GO:0019730 biolink:NamedThing antimicrobial humoral response An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus. got7fsn_ti GO:0006960|GO:0019735 biological_process owl:Class
GO:0035633 biolink:NamedThing maintenance of blood-brain barrier Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation. got7fsn_ti maintenance of BBB|maintenance of blood/brain barrier Homeostasis and maintenance processes are regulatory processes, therefore, regulation child terms, such as: regulation of maintenance of blood-brain barrier, should not exist for these terms. Instead, for capturing regulation at the blood-brain barrier, consider using the part_of child term: regulation of blood-brain barrier permeability. bf 2011-01-07T10:33:11Z biological_process owl:Class
GO:1905499 biolink:NamedThing trichome papilla formation The aggregation, arrangement and bonding together of a set of components to form a trichome papilla. got7fsn_ti trichome papilla assembly tb 2016-09-27T00:28:06Z biological_process owl:Class
GO:0044735 biolink:NamedThing envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. got7fsn_ti envenomation resulting in negative regulation of ASIC channel activity in other organism jl 2012-11-06T16:05:58Z biological_process owl:Class
GO:0044738 biolink:NamedThing negative regulation of acid-sensing ion channel in other organism Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism. got7fsn_ti negative regulation of ASIC channel in other organism jl 2012-11-06T16:55:23Z biological_process owl:Class
GO:0033163 biolink:NamedThing microneme membrane The lipid bilayer surrounding a microneme. got7fsn_ti cellular_component owl:Class
GO:0044327 biolink:NamedThing dendritic spine head Distal part of the dendritic spine, that carries the post-synaptic density. got7fsn_ti spine head jl 2010-08-18T02:33:12Z NIF_Subcellular:sao952643730 cellular_component owl:Class
GO:0014069 biolink:NamedThing postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. got7fsn_ti neuronal postsynaptic density|post synaptic density|post-synaptic density|postsynaptic density of dendrite pr 2013-07-02T09:44:28Z GO:0097481|GO:0097483 Wikipedia:Postsynaptic_density|NIF_Subcellular:sao1196688972 cellular_component owl:Class
GO:0099565 biolink:NamedThing chemical synaptic transmission, postsynaptic The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol. got7fsn_ti postsynaptic process involved in chemical synaptic transmission biological_process owl:Class
GO:0006888 biolink:NamedThing endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. got7fsn_ti anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi|anterograde transport, endoplasmic reticulum to Golgi|rough ER to cis-Golgi transport|rough endoplasmic reticulum to cis-Golgi transport|rough ER to cis-Golgi vesicle-mediated transport|ER to Golgi vesicle-mediated transport|endoplasmic reticulum to Golgi vesicle-mediated transport|anterograde transport, ER to Golgi|rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport|endoplasmic reticulum to Golgi transport|ER to Golgi transport|anterograde vesicle-mediated transport, ER to Golgi|anterograde (ER to Golgi) transport GO:0048221 biological_process owl:Class
GO:0086061 biolink:NamedThing voltage-gated sodium channel activity involved in bundle of His cell action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated sodium channel activity involved in bundle of His cardiac muscle cell action potential dph 2011-11-17T12:58:13Z molecular_function owl:Class
NCBITaxon:33392 biolink:NamedThing got7fsn_ti owl:Class
GO:1990770 biolink:NamedThing small intestine smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine. got7fsn_ti sl 2015-06-11T18:02:33Z biological_process owl:Class
GO:0000084 biolink:NamedThing mitotic S phase The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle. got7fsn_ti S phase of mitotic cell cycle|S-phase of mitotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0051329 biolink:NamedThing mitotic interphase The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs. got7fsn_ti interphase of mitotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:1905293 biolink:NamedThing negative regulation of neural crest cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation. got7fsn_ti down regulation of neural crest cell differentiation|down-regulation of neural crest cell differentiation|downregulation of neural crest cell differentiation|inhibition of neural crest cell differentiation rl 2016-06-28T15:02:09Z biological_process owl:Class
GO:1905224 biolink:NamedThing clathrin-coated pit assembly The aggregation, arrangement and bonding together of a set of components to form a clathrin-coated pit. got7fsn_ti coated pit assembly|coated pit formation|clathrin-coated pit formation bf 2016-06-07T11:33:28Z biological_process owl:Class
GO:0048268 biolink:NamedThing clathrin coat assembly The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. got7fsn_ti clathrin cage assembly biological_process owl:Class
GO:0051283 biolink:NamedThing negative regulation of sequestering of calcium ion Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. got7fsn_ti negative regulation of calcium ion (Ca2+) sequestering|negative regulation of storage of calcium ion (Ca2+)|negative regulation of calcium ion (Ca2+) sequestration|inhibition of sequestering of calcium ion|negative regulation of sequestering of calcium ion (Ca2+)|negative regulation of calcium ion (Ca2+) storage|down regulation of sequestering of calcium ion|downregulation of sequestering of calcium ion|negative regulation of calcium ion (Ca2+) retention|negative regulation of retention of calcium ion (Ca2+)|negative regulation of sequestration of calcium ion (Ca2+)|down-regulation of sequestering of calcium ion biological_process owl:Class
GO:0061399 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus. got7fsn_ti dph 2012-01-10T09:28:52Z biological_process owl:Class
GO:0005944 biolink:NamedThing phosphatidylinositol 3-kinase complex, class IB A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks. got7fsn_ti phosphoinositide 3-kinase complex, class IB|1-phosphatidylinositol-4-phosphate kinase, class IB complex|class IB PI3K complex|1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex GO:0035031 cellular_component owl:Class
GO:1904414 biolink:NamedThing positive regulation of cardiac ventricle development Any process that activates or increases the frequency, rate or extent of cardiac ventricle development. got7fsn_ti upregulation of cardiac ventricle development|up-regulation of cardiac ventricle development|activation of cardiac ventricle development|up regulation of cardiac ventricle development sl 2015-06-25T19:52:27Z biological_process owl:Class
GO:0046935 biolink:NamedThing 1-phosphatidylinositol-3-kinase regulator activity Modulates the activity of the enzyme 1-phosphatidylinositol-3-kinase activity. got7fsn_ti 1-phosphatidylinositol 3-kinase regulator activity|phosphatidylinositol 3-kinase, class I, regulator activity See also the molecular function term '1-phosphatidylinositol-3-kinase activity ; GO:0016303'. molecular_function owl:Class
GO:0016303 biolink:NamedThing 1-phosphatidylinositol-3-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+). got7fsn_ti Vps34p|1-phosphatidylinositol 3-kinase activity|phosphatidylinositol 3-kinase activity, class III|type I phosphatidylinositol kinase activity|phosphatidylinositol 3-kinase activity, class I|phosphatidylinositol 3-kinase, class I, catalyst activity|PI3-kinase activity|type III phosphoinositide 3-kinase activity|ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity|PI3K|phosphatidylinositol 3-kinase activity, class II|PtdIns-3-kinase activity GO:0004429 Reactome:R-HSA-5672012|RHEA:12709|KEGG_REACTION:R03362|Reactome:R-HSA-6798174|MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN|EC:2.7.1.137|Reactome:R-HSA-1675961|Reactome:R-HSA-1676024|Reactome:R-HSA-109699|Reactome:R-HSA-1675939 molecular_function owl:Class
GO:0008919 biolink:NamedThing lipopolysaccharide glucosyltransferase I activity Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide. got7fsn_ti UDP-glucose:lipopolysaccharide glucosyltransferase activity|lipopolysaccharide glucosyltransferase activity|UDPglucose:lipopolysaccharide glucosyltransferase activity|LPS glucosyltransferase I activity|uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I|UDPglucose:lipopolysaccharide glucosyltransferase I|uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity EC:2.4.1.58|MetaCyc:2.4.1.58-RXN molecular_function owl:Class
GO:0048493 biolink:NamedThing plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex A complex, located in the plasma membrane-derived thylakoid, containing either both large and small subunits or just small subunits. It carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. got7fsn_ti plasma membrane ribulose bisphosphate carboxylase complex|RubisCO complex|ribulose bisphosphate carboxylase complex cellular_component owl:Class
GO:0050253 biolink:NamedThing retinyl-palmitate esterase activity Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+. got7fsn_ti retinyl palmitate hydrolyase activity|retinyl-palmitate palmitohydrolase activity|retinyl ester hydrolase activity|retinyl palmitate hydrolase activity MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN|Reactome:R-HSA-975594|KEGG_REACTION:R02368|EC:3.1.1.21|RHEA:21508|Reactome:R-HSA-2404133|Reactome:R-HSA-8848355|Reactome:R-HSA-975593 molecular_function owl:Class
GO:1902175 biolink:NamedThing regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. got7fsn_ti regulation of intrinsic apoptotic signaling pathway in response to oxidative stress pr 2013-05-29T18:30:00Z biological_process owl:Class
GO:0036473 biolink:NamedThing cell death in response to oxidative stress Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus. got7fsn_ti This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred in response to an oxidative stress stimulus, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death', GO:0006915 'apoptotic process' or GO:0097468 'programmed cell death in response to reactive oxygen species'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. bf 2014-07-21T11:37:03Z biological_process owl:Class
GO:0098645 biolink:NamedThing collagen network A supramolecular complex that consists of collagen triple helices associated to form a network. got7fsn_ti cellular_component owl:Class
GO:0000274 biolink:NamedThing mitochondrial proton-transporting ATP synthase, stator stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. got7fsn_ti mitochondrial proton-transporting ATP synthase, peripheral stalk cellular_component owl:Class
GO:0000276 biolink:NamedThing mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. got7fsn_ti cellular_component owl:Class
GO:0072200 biolink:NamedThing negative regulation of mesenchymal cell proliferation involved in ureter development Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. got7fsn_ti negative regulation of ureteral mesenchymal cell proliferation|negative regulation of ureter mesenchymal cell proliferation mah 2010-03-01T03:42:31Z biological_process owl:Class
GO:0021646 biolink:NamedThing vagus nerve formation The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. got7fsn_ti CN X formation|CN X biosynthesis biological_process owl:Class
GO:0021644 biolink:NamedThing vagus nerve morphogenesis The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. got7fsn_ti CN X morphogenesis biological_process owl:Class
GO:0006489 biolink:NamedThing dolichyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative. got7fsn_ti dolichyl diphosphate formation|dolichyl diphosphate anabolism|dolichyl diphosphate synthesis|dolichyl diphosphate biosynthesis biological_process owl:Class
GO:0030707 biolink:NamedThing ovarian follicle cell development The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0099054 biolink:NamedThing presynapse assembly The aggregation, arrangement and bonding together of a set of components to form a presynapse. got7fsn_ti presynapse biogenesis|presynaptic terminal assembly biological_process owl:Class
GO:0015180 biolink:NamedThing L-alanine transmembrane transporter activity Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. got7fsn_ti L-alanine transporter activity molecular_function owl:Class
GO:0015808 biolink:NamedThing L-alanine transport The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0072284 biolink:NamedThing metanephric S-shaped body morphogenesis The process in which the metanephric S-shaped body is generated and organized. The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros. got7fsn_ti mah 2010-04-01T03:41:36Z biological_process owl:Class
GO:1903378 biolink:NamedThing positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. got7fsn_ti activation of neuron apoptosis in response to oxidative stress|positive regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|up regulation of neuron apoptosis in response to oxidative stress|up regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|upregulation of neuron apoptosis in response to oxidative stress|positive regulation of neuron apoptosis in response to oxidative stress|activation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|up-regulation of neuron apoptosis in response to oxidative stress|upregulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|up-regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress bf 2014-08-26T13:03:36Z biological_process owl:Class
GO:1900119 biolink:NamedThing positive regulation of execution phase of apoptosis Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis. got7fsn_ti up-regulation of execution phase of apoptosis|up regulation of execution phase of apoptosis|upregulation of execution phase of apoptosis|activation of execution phase of apoptosis pr 2012-02-22T11:26:27Z biological_process owl:Class
GO:0044823 biolink:NamedThing retroviral integrase activity Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism. got7fsn_ti jl 2014-02-04T14:09:34Z molecular_function owl:Class
GO:0072223 biolink:NamedThing metanephric glomerular mesangium development The process whose specific outcome is the progression of the metanephric glomerular mesangium over time, from its formation to the mature structure. The metanephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the metanephros, which helps to support the capillary loops in a renal glomerulus. got7fsn_ti mah 2010-03-18T03:35:56Z biological_process owl:Class
GO:0010465 biolink:NamedThing nerve growth factor receptor activity Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity. got7fsn_ti beta-nerve growth factor receptor activity|NGF receptor activity molecular_function owl:Class
GO:0048406 biolink:NamedThing nerve growth factor binding Binding to nerve growth factor (NGF). got7fsn_ti neurotrophin TRKA receptor activity|beta-nerve growth factor binding|NGF binding molecular_function owl:Class
GO:0045258 biolink:NamedThing plasma membrane succinate dehydrogenase complex (ubiquinone) The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. got7fsn_ti cellular_component owl:Class
GO:0005840 biolink:NamedThing ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. got7fsn_ti free ribosome|ribosomal RNA|membrane bound ribosome GO:0033279 NIF_Subcellular:sao1429207766|Wikipedia:Ribosome cellular_component owl:Class
GO:0061071 biolink:NamedThing urethra epithelium development The progression of the urethra epithelium over time from its initial formation to the mature structure. The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes. got7fsn_ti dph 2010-03-12T08:36:53Z biological_process owl:Class
GO:0051330 biolink:NamedThing meiotic G1 phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis. got7fsn_ti G1 phase of meiotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0017015 biolink:NamedThing regulation of transforming growth factor beta receptor signaling pathway Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway. got7fsn_ti regulation of TGF-beta receptor signaling pathway|regulation of TGFbeta receptor signaling pathway|regulation of transforming growth factor beta receptor signalling pathway biological_process owl:Class
GO:0071560 biolink:NamedThing cellular response to transforming growth factor beta stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus. got7fsn_ti cellular response to TGFbeta stimulus|cellular response to TGF-beta stimulus mah 2010-01-20T11:51:18Z biological_process owl:Class
GO:0030314 biolink:NamedThing junctional membrane complex Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules). got7fsn_ti triad junction cellular_component owl:Class
GO:2000062 biolink:NamedThing negative regulation of ureter smooth muscle cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation. got7fsn_ti jl 2010-08-20T01:44:23Z biological_process owl:Class
GO:0038121 biolink:NamedThing C-C motif chemokine 21 receptor activity Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti CCL21 receptor activity bf 2012-03-22T01:28:06Z molecular_function owl:Class
GO:0038116 biolink:NamedThing chemokine (C-C motif) ligand 21 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti chemokine (C-C motif) ligand 21 signalling pathway|C-C chemokine receptor type 7 signaling pathway|CCL21-mediated signaling pathway The C-C chemokine CCL21 s a known agonist of the chemokine receptor type 7 (CCR7). Consider instead annotating to the child term 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. bf 2012-03-22T11:30:47Z biological_process owl:Class
GO:0032338 biolink:NamedThing regulation of inhibin secretion Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell. got7fsn_ti biological_process owl:Class
GO:0050886 biolink:NamedThing endocrine process The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system. got7fsn_ti endocrine physiology|endocrine physiological process biological_process owl:Class
GO:0015115 biolink:NamedThing silicate transmembrane transporter activity Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. got7fsn_ti molecular_function owl:Class
GO:0015708 biolink:NamedThing silicic acid import across plasma membrane The directed movement of silicates from outside of a cell, across the plasma membrane and into the cytosol. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates. got7fsn_ti silicon uptake|silicic acid transport|silicic acid import|silicate transport tb 2013-04-17T20:53:16Z GO:1902067|GO:0051207 biological_process owl:Class
GO:0061053 biolink:NamedThing somite development The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. got7fsn_ti dph 2010-03-02T12:05:13Z biological_process owl:Class
GO:0061009 biolink:NamedThing common bile duct development The progression of the common bile duct over time, from its formation to the mature structure. The common bile duct is formed from the joining of the common hepatic duct running from the liver, and the cystic duct running from the gall bladder. The common bile duct transports bile from the liver and gall bladder to the intestine. got7fsn_ti extrahepatic bile duct development|bile duct development|CBD development|EHBD development dph 2010-01-22T09:17:13Z biological_process owl:Class
GO:0061008 biolink:NamedThing hepaticobiliary system development The progression of the hepaticobiliary system over time, from its formation to the mature structure. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. got7fsn_ti hepatobiliary system development dph 2010-01-22T09:11:59Z biological_process owl:Class
GO:0015112 biolink:NamedThing nitrate transmembrane transporter activity Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. got7fsn_ti nitrite/nitrate porter activity https://github.com/geneontology/go-ontology/issues/21337 RHEA:34923 molecular_function owl:Class
GO:0015706 biolink:NamedThing nitrate transport The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti low affinity nitrate transport|low-affinity nitrate transport GO:0006872|GO:0080055 biological_process owl:Class
GO:1902423 biolink:NamedThing regulation of attachment of mitotic spindle microtubules to kinetochore Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation. got7fsn_ti regulation of attachment of spindle microtubules to mitotic chromosome|regulation of attachment of spindle microtubules to kinetochore during mitosis|regulation of attachment of spindle microtubules to kinetochore involved in mitosis|regulation of mitotic bipolar attachment|regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|regulation of mitotic attachment of spindle microtubules to kinetochore vw 2013-09-19T10:33:38Z biological_process owl:Class
GO:0072021 biolink:NamedThing ascending thin limb development The process whose specific outcome is the progression of an ascending thin limb over time, from its formation to the mature structure. The ascending thin limb is a segment of a nephron tubule lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent. got7fsn_ti mah 2010-01-25T02:37:13Z biological_process owl:Class
GO:0072070 biolink:NamedThing loop of Henle development The process whose specific outcome is the progression of the loop of Henle over time, from its formation to the mature structure. The loop of Henle is a nephron tubule that connects the proximal convoluted tubule to the distal convoluted tubule. got7fsn_ti intermediate tubule development mah 2010-01-25T04:20:27Z GO:0072018 biological_process owl:Class
GO:0048540 biolink:NamedThing bursa of Fabricius development The process whose specific outcome is the progression of the bursa of Fabricius over time, from its formation to the mature structure. The bursa of Fabricius is an organ found in birds involved in B cell differentiation. got7fsn_ti biological_process owl:Class
NCBITaxon:8457 biolink:NamedThing got7fsn_ti owl:Class
GO:0042714 biolink:NamedThing dosage compensation complex assembly The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes. got7fsn_ti biological_process owl:Class
GO:0075523 biolink:NamedThing viral translational frameshifting A process which occurs during viral translation, which involves a translational recoding mechanism called programmed ribosomal frameshifting. This causes the ribosome to alter its reading of the mRNA to an a different open reading frame to produce alternate viral proteins. got7fsn_ti ribosomal frameshifting involved in viral translation This term is intended to annotate gene products involved in the process of viral translational frameshifting, not viral proteins produced by this translation process. jl 2011-08-03T02:48:46Z VZ:860 biological_process owl:Class
GO:0006384 biolink:NamedThing transcription initiation from RNA polymerase III promoter Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. got7fsn_ti transcription initiation from RNA polymerase III type 2 promoter|transcription initiation from RNA polymerase III type 1 promoter|transcription initiation from RNA polymerase III type 3 promoter|transcription initiation from Pol III promoter|transcription initiation from RNA polymerase III hybrid type promoter Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. krc 2010-08-19T04:33:52Z GO:0001022|GO:0001024|GO:0001036|GO:0001023 biological_process owl:Class
GO:0031588 biolink:NamedThing nucleotide-activated protein kinase complex A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae). got7fsn_ti Snf1 kinase complex|AMP-activated protein kinase complex|SNF1/AMPK protein kinase complex|ADP-activated protein kinase complex|Snf1 serine/threonine protein kinase complex|AMPK complex|5'-AMP-activated protein kinase complex cellular_component owl:Class
GO:0034743 biolink:NamedThing APC-IQGAP complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC) and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0060322 biolink:NamedThing head development The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body. got7fsn_ti biological_process owl:Class
GO:0030426 biolink:NamedThing growth cone The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. got7fsn_ti Wikipedia:Growth_cone cellular_component owl:Class
GO:0071021 biolink:NamedThing U2-type post-spliceosomal complex A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6. got7fsn_ti yeast U2-type spliceosomal complex A2-3|mammalian U2-type spliceosomal complex C2|GT-AG post-spliceosomal complex|major post-spliceosomal complex mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0005078 biolink:NamedThing MAP-kinase scaffold activity The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. got7fsn_ti MAP-kinase scaffold protein activity molecular_function owl:Class
GO:0043410 biolink:NamedThing positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. got7fsn_ti upregulation of MAPKKK cascade|positive regulation of MAP kinase cascade|stimulation of MAPK cascade|positive regulation of MAPKKK cascade|up regulation of MAPKKK cascade|up-regulation of MAPK cascade|activation of MAPKKK cascade|positive regulation of mitogen-activated protein kinase cascade|positive regulation of mitogen-activated protein kinase kinase kinase cascade|up-regulation of MAPKKK cascade|activation of MAPK cascade|positive regulation of MAP kinase kinase kinase cascade|upregulation of MAPK cascade|stimulation of MAPKKK cascade|positive regulation of mitogen activated protein kinase kinase kinase cascade biological_process owl:Class
GO:0048805 biolink:NamedThing imaginal disc-derived genitalia morphogenesis The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc. got7fsn_ti genital morphogenesis biological_process owl:Class
GO:0042603 biolink:NamedThing capsule A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication. got7fsn_ti GO:0030113|GO:0042604 Wikipedia:Capsule_(microbiology) cellular_component owl:Class
GO:0001520 biolink:NamedThing outer dense fiber A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins. got7fsn_ti outer dense fibre cellular_component owl:Class
GO:0048567 biolink:NamedThing ectodermal digestive tract morphogenesis The process in which the anatomical structures of the ectodermal digestive tract are generated and organized. The ectodermal digestive tract includes those portions of the digestive tract that are derived from ectoderm. got7fsn_ti ectodermal gut morphogenesis biological_process owl:Class
GO:1990719 biolink:NamedThing C1 axonemal microtubule One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections. got7fsn_ti C1 tubule krc 2015-03-27T22:55:12Z cellular_component owl:Class
GO:0097540 biolink:NamedThing axonemal central pair Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia. got7fsn_ti axoneme microtubule central pair|axonemal microtubule central pair|central-pair microtubules|central pair|axoneme central pair pr 2013-12-12T11:07:09Z cellular_component owl:Class
GO:0030905 biolink:NamedThing retromer, tubulation complex The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6. got7fsn_ti SNX-BAR dimer|retromer complex, outer shell|heterodimeric membrane-deforming retromer subcomplex cellular_component owl:Class
GO:0030904 biolink:NamedThing retromer complex A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35. got7fsn_ti cellular_component owl:Class
GO:0036356 biolink:NamedThing cyclic 2,3-diphosphoglycerate synthetase activity Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate. got7fsn_ti CPGS activity|cDPGS activity This reaction is the intramolecular cyclization of 2,3-diphosphoglycerate to cyclic 2,3-diphosphoglycerate and is the second step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG). bf 2012-09-19T14:59:19Z molecular_function owl:Class
GO:1901369 biolink:NamedThing cyclic 2,3-bisphospho-D-glycerate biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic 2,3-bisphospho-D-glyceric acid. got7fsn_ti cyclic 2,3-bisphospho-D-glyceric acid formation|cyclic 2,3-bisphospho-D-glyceric acid biosynthetic process|cyclic 2,3-diphosphoglycerate biosynthesis|cyclic 2,3-bisphospho-D-glyceric acid biosynthesis|cyclic 2,3-bisphospho-D-glyceric acid anabolism|cyclic 2,3-bisphospho-D-glyceric acid synthesis|cDPG biosynthesis bf 2012-09-19T14:17:57Z biological_process owl:Class
GO:0055008 biolink:NamedThing cardiac muscle tissue morphogenesis The process in which the anatomical structures of cardiac muscle tissue are generated and organized. got7fsn_ti myocardium morphogenesis|heart muscle morphogenesis biological_process owl:Class
GO:0030935 biolink:NamedThing sheet-forming collagen trimer A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers assemble into a sheet. got7fsn_ti hexagonal network-forming collagen cellular_component owl:Class
GO:0070450 biolink:NamedThing interleukin4-interleukin-4 receptor complex A protein complex that is formed by the association of a heterodimeric interleukin-4 receptor complex with an interleukin-4 molecule. got7fsn_ti IL4-IL4 receptor complex|IL4-IL4R-IL2RG complex cellular_component owl:Class
GO:1902675 biolink:NamedThing left ventral basal body Any ciliary basal body that is part of a left ventral flagellum found in Giardia species (trophozoite stage). got7fsn_ti ciliary basal body of left ventral flagellum|cilium basal body of left ventral cilium|left ventral flagellum ciliary basal body|microtubule basal body of left ventral cilium|cilial basal body of left ventral flagellum|ciliary basal body of left ventral cilium|microtubule basal body of left ventral flagellum|cilium basal body of left ventral flagellum|cilial basal body of left ventral cilium Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T14:54:54Z cellular_component owl:Class
GO:0034633 biolink:NamedThing retinol transport The directed movement of retinol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. got7fsn_ti vitamin A1 transport biological_process owl:Class
GO:0016504 biolink:NamedThing peptidase activator activity Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. got7fsn_ti protease activator activity Reactome:R-HSA-168865 molecular_function owl:Class
GO:0010952 biolink:NamedThing positive regulation of peptidase activity Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. got7fsn_ti tb 2009-04-27T11:54:32Z biological_process owl:Class
GO:0035405 biolink:NamedThing histone-threonine phosphorylation The modification of histones by addition of a phosphate group to a threonine residue. got7fsn_ti histone threonine phosphorylation bf 2010-03-24T10:09:21Z biological_process owl:Class
GO:1905940 biolink:NamedThing negative regulation of gonad development Any process that stops, prevents or reduces the frequency, rate or extent of gonad development. got7fsn_ti negative regulation of gonadogenesis|downregulation of gonad development|downregulation of gonadogenesis|down regulation of gonadogenesis|inhibition of gonadogenesis|down regulation of gonad development|down-regulation of gonadogenesis|inhibition of gonad development|down-regulation of gonad development hbye 2017-02-09T17:01:59Z biological_process owl:Class
GO:0010060 biolink:NamedThing negative regulation of atrichoblast fate specification Any process that suppresses atrichoblast fate specification. got7fsn_ti downregulation of atrichoblast fate|down regulation of atrichoblast fate|inhibition of atrichoblast fate|down-regulation of atrichoblast fate biological_process owl:Class
GO:0005915 biolink:NamedThing zonula adherens A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells. got7fsn_ti adhesion belt|intermediate junction|belt desmosome|zonula adhaerens NIF_Subcellular:sao1400623473 cellular_component owl:Class
GO:0043296 biolink:NamedThing apical junction complex A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability. got7fsn_ti apical cell junction complex|apical junction cellular_component owl:Class
GO:0061793 biolink:NamedThing chromatin lock complex A chromatin silencing complex that binds and bridges separate nucleosomal histones resulting in heterochromatin assembly and chromatin looping. got7fsn_ti nucleosome bridging complex dph 2016-09-09T13:47:27Z cellular_component owl:Class
GO:0061575 biolink:NamedThing cyclin-dependent protein serine/threonine kinase activator activity Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. got7fsn_ti cyclin-dependent protein kinase 5 activator activity dph 2013-10-08T13:50:35Z GO:0016535|GO:0016534 molecular_function owl:Class
GO:0045737 biolink:NamedThing positive regulation of cyclin-dependent protein serine/threonine kinase activity Any process that activates or increases the frequency, rate or extent of CDK activity. got7fsn_ti activation of cyclin-dependent protein kinase activity|upregulation of cyclin-dependent protein kinase activity|stimulation of cyclin-dependent protein kinase activity|up-regulation of cyclin-dependent protein kinase activity|positive regulation of CDK activity|up regulation of cyclin-dependent protein kinase activity|positive regulation of cyclin-dependent protein kinase activity biological_process owl:Class
GO:0060468 biolink:NamedThing prevention of polyspermy The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. got7fsn_ti negative regulation of fertilization involved in egg activation|polyspermy block biological_process owl:Class
GO:1990500 biolink:NamedThing eif4e-cup complex A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo. got7fsn_ti eukaryotic translation initiation factor 4E-cup complex An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction). bhm 2014-09-30T12:31:49Z cellular_component owl:Class
GO:2000825 biolink:NamedThing positive regulation of androgen receptor activity Any process that activates or increases the frequency, rate or extent of androgen receptor activity. got7fsn_ti yaf 2011-07-15T10:56:14Z biological_process owl:Class
GO:0002917 biolink:NamedThing regulation of peripheral B cell anergy Any process that modulates the frequency, rate, or extent of peripheral B cell anergy. got7fsn_ti biological_process owl:Class
GO:0019724 biolink:NamedThing B cell mediated immunity Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. got7fsn_ti B-cell mediated immune effector process|B-lymphocyte mediated immune effector process|B lymphocyte mediated immunity|B lymphocyte mediated immune effector process|B-cell mediated immunity|B-lymphocyte mediated immunity biological_process owl:Class
GO:0010323 biolink:NamedThing negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent). got7fsn_ti negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway biological_process owl:Class
GO:0008052 biolink:NamedThing sensory organ boundary specification The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained. got7fsn_ti sense organ boundary specification biological_process owl:Class
GO:0097487 biolink:NamedThing multivesicular body, internal vesicle A membrane-bounded vesicle wholly contained within a multivesicular body. got7fsn_ti pr 2013-07-08T20:34:51Z cellular_component owl:Class
GO:0016314 biolink:NamedThing phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. got7fsn_ti PI(3,4,5)P3 3-phosphatase activity|MMAC1|1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity|PtdIns(3,4,5)P3 3-phosphatase activity|PI(3)P 3-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity MetaCyc:3.1.3.67-RXN|RHEA:25017|Reactome:R-HSA-2317387|EC:3.1.3.67|Reactome:R-HSA-202237|Reactome:R-HSA-199456 molecular_function owl:Class
GO:0005931 biolink:NamedThing axonemal nexin link A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules. got7fsn_ti axonemal interdoublet link|nexin complex cellular_component owl:Class
GO:0030671 biolink:NamedThing clathrin-coated phagocytic vesicle membrane The lipid bilayer surrounding a clathrin-coated phagocytic vesicle. got7fsn_ti cellular_component owl:Class
GO:0048382 biolink:NamedThing mesendoderm development The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues. got7fsn_ti biological_process owl:Class
GO:0048143 biolink:NamedThing astrocyte activation A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti biological_process owl:Class
GO:1990901 biolink:NamedThing old cell pole The cell pole distal from the most recent cell division. got7fsn_ti pr 2015-11-17T16:42:16Z cellular_component owl:Class
GO:0061235 biolink:NamedThing mesenchymal stem cell maintenance involved in mesonephric nephron morphogenesis The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti dph 2010-08-19T02:57:11Z biological_process owl:Class
GO:0010094 biolink:NamedThing specification of carpel identity The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0016010 biolink:NamedThing dystrophin-associated glycoprotein complex A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase. got7fsn_ti DGC|dystrophin glycoprotein complex cellular_component owl:Class
GO:1990225 biolink:NamedThing rhoptry neck Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion. got7fsn_ti pr 2013-11-03T14:19:26Z cellular_component owl:Class
GO:0048864 biolink:NamedThing stem cell development The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate. got7fsn_ti biological_process owl:Class
GO:0007597 biolink:NamedThing blood coagulation, intrinsic pathway A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X. got7fsn_ti See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'. biological_process owl:Class
GO:0032266 biolink:NamedThing phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. got7fsn_ti PtdIns-3-P binding|phosphatidylinositol 3-phosphate binding molecular_function owl:Class
GO:0002331 biolink:NamedThing pre-B cell allelic exclusion Expression of a single heavy chain allele during pre-B cell differentiation. got7fsn_ti pre-B lymphocyte allelic exclusion biological_process owl:Class
GO:0002329 biolink:NamedThing pre-B cell differentiation The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments. got7fsn_ti pre-B cell development|pre-B lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:2000235 biolink:NamedThing regulation of tRNA processing Any process that modulates the frequency, rate or extent of tRNA processing. got7fsn_ti regulation of tRNA maturation mah 2010-11-10T12:15:08Z biological_process owl:Class
GO:1905699 biolink:NamedThing regulation of xenobiotic detoxification by transmembrane export across the plasma membrane Any process that modulates the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti regulation of drug transmembrane export|regulation of xenobiotic transmembrane export https://github.com/geneontology/go-ontology/issues/17083|https://github.com/geneontology/go-ontology/issues/19460 sl 2016-11-15T16:46:28Z biological_process owl:Class
GO:0009410 biolink:NamedThing response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti response to drug|drug resistance|drug susceptibility/resistance https://github.com/geneontology/go-ontology/issues/19460 GO:0017035|GO:0042493|GO:0017104 biological_process owl:Class
GO:0051724 biolink:NamedThing NAD transmembrane transporter activity Enables the transfer of NAD from one side of a membrane to the other. got7fsn_ti oxidized nicotinamide adenine dinucleotide transmembrane transporter activity|NAD (oxidized) transporter activity|reduced NAD transporter activity|NAD (reduced) transporter activity|nicotinamide adenine dinucleotide transmembrane transporter activity|NAD transporter activity|reduced nicotinamide adenine dinucleotide transmembrane transporter activity|oxidized NAD transporter activity|NAD+ transporter activity|NADH transporter activity NAD carrier jl 2012-09-19T13:21:08Z GO:1901368 molecular_function owl:Class
GO:0035352 biolink:NamedThing NAD transmembrane transport The process in which a nicotinamide adenine dinucleotide is transported across a membrane; transport may be of either the oxidized form, NAD, or the reduced form, NADH. got7fsn_ti NAD membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-03-04T03:46:20Z biological_process owl:Class
GO:1901165 biolink:NamedThing positive regulation of trophoblast cell migration Any process that activates or increases the frequency, rate or extent of trophoblast cell migration. got7fsn_ti activation of trophoblast cell migration|up regulation of trophoblast cell migration|up-regulation of trophoblast cell migration|upregulation of trophoblast cell migration vk 2012-07-19T07:53:35Z biological_process owl:Class
GO:0000932 biolink:NamedThing P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. got7fsn_ti P body|cytoplasmic mRNA processing body|cytoplasmic foci Wikipedia:P_body cellular_component owl:Class
GO:0009099 biolink:NamedThing valine biosynthetic process The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid. got7fsn_ti valine formation|valine synthesis|valine anabolism|valine biosynthesis MetaCyc:VALSYN-PWY biological_process owl:Class
GO:0099526 biolink:NamedThing presynapse to nucleus signaling pathway A series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). got7fsn_ti presynaptic signaling to nucleus This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term. biological_process owl:Class
GO:0048615 biolink:NamedThing embryonic anterior midgut (ectodermal) morphogenesis The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the embryonic phase. got7fsn_ti biological_process owl:Class
GO:0005863 biolink:NamedThing striated muscle myosin thick filament Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils. got7fsn_ti cellular_component owl:Class
GO:0005859 biolink:NamedThing muscle myosin complex A filament of myosin found in a muscle cell of any type. got7fsn_ti cellular_component owl:Class
GO:1990160 biolink:NamedThing DnaB-DnaC-Rep-PriC complex A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. got7fsn_ti DnaB-DnaC-Rep-PriC preprimosome|phi-X174-type preprimosome bhm 2013-08-02T12:05:25Z cellular_component owl:Class
GO:0090734 biolink:NamedThing site of DNA damage A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. got7fsn_ti tb 2017-02-03T17:24:08Z Wikipedia:DNA_repair cellular_component owl:Class
GO:0032468 biolink:NamedThing Golgi calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings. got7fsn_ti regulation of calcium ion concentration in Golgi|regulation of Golgi calcium ion concentration|Golgi calcium ion concentration regulation|calcium ion homeostasis in Golgi biological_process owl:Class
GO:0021767 biolink:NamedThing mammillary body development The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei. got7fsn_ti biological_process owl:Class
GO:0003388 biolink:NamedThing neuron development involved in amphid sensory organ development The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ. got7fsn_ti dph 2009-12-09T09:18:06Z biological_process owl:Class
GO:0003387 biolink:NamedThing neuron differentiation involved in amphid sensory organ development The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland. got7fsn_ti dph 2009-12-09T09:15:00Z biological_process owl:Class
GO:0097444 biolink:NamedThing spine apparatus A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum. got7fsn_ti dense material pr 2012-12-06T14:05:58Z NIF_Subcellular:sao725931194 cellular_component owl:Class
GO:0032969 biolink:NamedThing endosomal scaffold complex A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling. got7fsn_ti MP1-p14 scaffolding complex|endosomal adaptor complex cellular_component owl:Class
GO:0031902 biolink:NamedThing late endosome membrane The lipid bilayer surrounding a late endosome. got7fsn_ti cellular_component owl:Class
GO:0061134 biolink:NamedThing peptidase regulator activity Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. got7fsn_ti dph 2010-05-17T01:15:24Z molecular_function owl:Class
GO:1905424 biolink:NamedThing regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation. got7fsn_ti regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|regulation of Wg signalling pathway involved in mDA neuron differentiation|regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|regulation of Wg signaling pathway involved in mDA neuron differentiation|regulation of Wg signalling pathway involved in midbrain DA neurogenesis|regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|regulation of frizzled signalling pathway involved in mDA neuron differentiation|regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wingless signalling pathway involved in mDA neuron differentiation|regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wingless signaling pathway involved in mDA neuron differentiation|regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of frizzled signaling pathway involved in mDA neuron differentiation|regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt-mediated midbrain DA neuron differentiation|regulation of Wnt signaling pathway involved in mDA neuron differentiation|regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|regulation of midbrain dopaminergic neuron differentiation by regulation of Wnt signaling|regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|regulation of Wg signaling pathway involved in midbrain DA neurogenesis|regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production bf 2016-09-07T10:03:36Z biological_process owl:Class
GO:1904948 biolink:NamedThing midbrain dopaminergic neuron differentiation The process in which a relatively unspecialized cell acquires the specialized features of a midbrain dopaminergic neuron. got7fsn_ti midbrain DA neurogenesis|mDA neuron differentiation|midbrain dopaminergic neuron production|DA neurogenesis from midbrain floor plate bf 2016-02-04T14:38:10Z biological_process owl:Class
GO:0071131 biolink:NamedThing alphaV-beta3 integrin-laminin alpha-4 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4. got7fsn_ti ITGAV-ITGB3-LAMA4 complex mah 2009-11-13T02:26:11Z cellular_component owl:Class
GO:0086056 biolink:NamedThing voltage-gated calcium channel activity involved in AV node cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated calcium channel activity involved in AV node cardiac muscle cell action potential|voltage-gated calcium channel activity involved in atrioventricular node cardiac muscle cell action potential dph 2011-11-17T12:24:22Z molecular_function owl:Class
GO:0086045 biolink:NamedThing membrane depolarization during AV node cell action potential The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti membrane depolarization during AV node cardiac muscle cell action potential|membrane depolarization during atrioventricular node cardiac muscle cell action potential dph 2011-11-16T10:45:18Z biological_process owl:Class
GO:0005682 biolink:NamedThing U5 snRNP A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes. got7fsn_ti snRNP U5 cellular_component owl:Class
GO:0006386 biolink:NamedThing termination of RNA polymerase III transcription The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues. got7fsn_ti transcription termination from RNA polymerase III promoter|RNA polymerase III transcription termination|RNA polymerase III transcription termination factor activity|transcription termination from Pol III promoter GO:0019225 biological_process owl:Class
GO:0061283 biolink:NamedThing specification of mesonephric distal tubule identity The process in which the distal tubule of the mesonephric nephron acquires its identity. got7fsn_ti dph 2010-09-02T01:42:10Z biological_process owl:Class
GO:0019910 biolink:NamedThing mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus. got7fsn_ti See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'. cellular_component owl:Class
GO:0035924 biolink:NamedThing cellular response to vascular endothelial growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. got7fsn_ti cellular response to VEGFA|cellular response to vascular endothelial growth factor|cellular response to VEGFB|cellular response to VEGF bf 2011-07-15T04:03:29Z biological_process owl:Class
GO:0021781 biolink:NamedThing glial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell. got7fsn_ti biological_process owl:Class
GO:0036463 biolink:NamedThing TRAIL receptor activity Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death. got7fsn_ti tumor necrosis factor-related apoptosis-inducing ligand receptor bf 2014-06-11T09:20:30Z molecular_function owl:Class
GO:0045569 biolink:NamedThing TRAIL binding Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. got7fsn_ti Apo-2L binding molecular_function owl:Class
GO:0071006 biolink:NamedThing U2-type catalytic step 1 spliceosome A spliceosomal complex that is formed by the displacement of the U1 and U4 snRNPs from the precatalytic spliceosome; the U2, U5 and U6 snRNPs remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the U2, and U5 and U6 snRNPs. got7fsn_ti major catalytic step 1 spliceosome|GT-AG catalytic step 1 spliceosome|mammalian U2-type spliceosomal complex B2|U2-type activated spliceosome|mammalian U2-type spliceosomal complex B*|yeast U2-type spliceosomal complex A1 mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0021690 biolink:NamedThing cerebellar molecular layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. got7fsn_ti biological_process owl:Class
GO:0070517 biolink:NamedThing DNA replication factor C core complex A protein complex containing three of the five subunits of eukaryotic replication factor C, those corresponding to human p40, p38, and p37. got7fsn_ti RFC core complex cellular_component owl:Class
GO:0061247 biolink:NamedThing mesonephric glomerular mesangium development The process whose specific outcome is the progression of the mesonephric glomerular mesangium over time, from its formation to the mature structure. The mesonephric glomerular mesangium is the thin membrane connective tissue composed of mesangial cells in the mesonephros, which helps to support the capillary loops in a renal glomerulus. got7fsn_ti dph 2010-08-30T12:59:25Z biological_process owl:Class
GO:0043363 biolink:NamedThing nucleate erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds. got7fsn_ti nucleate RBC differentiation|nucleate red blood cell differentiation biological_process owl:Class
GO:0010216 biolink:NamedThing maintenance of DNA methylation Any process involved in maintaining the methylation state of a nucleotide sequence. got7fsn_ti biological_process owl:Class
GO:0071359 biolink:NamedThing cellular response to dsRNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. got7fsn_ti cellular response to double-stranded RNA mah 2009-12-11T03:00:32Z biological_process owl:Class
GO:0070365 biolink:NamedThing hepatocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver. got7fsn_ti liver cell differentiation biological_process owl:Class
GO:0070152 biolink:NamedThing mitochondrial isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA in a mitochondrion, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0000766 biolink:NamedThing negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses. got7fsn_ti negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation|desensitization to pheromone during pheromone-induced unidirectional conjugation|adaptation to pheromone during pheromone-induced unidirectional conjugation biological_process owl:Class
GO:0000765 biolink:NamedThing response to pheromone regulating pheromone-induced unidirectional conjugation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation. got7fsn_ti response to pheromone during pheromone-induced unidirectional biological_process owl:Class
GO:0060709 biolink:NamedThing glycogen cell differentiation involved in embryonic placenta development The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer. got7fsn_ti dph 2009-06-09T10:41:08Z biological_process owl:Class
GO:0060712 biolink:NamedThing spongiotrophoblast layer development The process in which the spongiotrophoblast layer of the placenta progresses from its formation to its mature state. got7fsn_ti dph 2009-06-09T03:33:40Z biological_process owl:Class
GO:0060053 biolink:NamedThing neurofilament cytoskeleton Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons. got7fsn_ti cellular_component owl:Class
GO:0030295 biolink:NamedThing protein kinase activator activity Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. got7fsn_ti molecular_function owl:Class
GO:0032147 biolink:NamedThing activation of protein kinase activity Any process that initiates the activity of an inactive protein kinase. got7fsn_ti protein kinase activation biological_process owl:Class
GO:0032282 biolink:NamedThing plastid acetyl-CoA carboxylase complex An acetyl-CoA carboxylase complex located in the stroma of a plastid. got7fsn_ti plastid ACCase complex cellular_component owl:Class
GO:0072115 biolink:NamedThing head kidney morphogenesis The process in which the anatomical structures of the head kidney are generated and organized. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. got7fsn_ti mah 2010-02-22T11:13:37Z biological_process owl:Class
GO:0048370 biolink:NamedThing lateral mesoderm formation The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts. got7fsn_ti lateral plate mesoderm formation|lateral plate mesoderm biosynthesis biological_process owl:Class
GO:0070745 biolink:NamedThing interleukin-35 complex A protein complex that is composed of an interleukin-12 alpha subunit (p35, product of the IL12A gene) and an EBI3 subunit and is secreted into the extracellular space. got7fsn_ti EBI3|IL12A|p35|IL-35 complex Note that this heterodimeric cytokine utilizes the same IL-12p35 subunit as its alpha chain as IL-12 uses and the same EBI3 subunit (product of EBI3, Epstein-Barr virus induced gene 3) as its beta chain as IL-27 uses. IL-35 requires both subunits -- there is no separate IL35 gene. mah 2009-06-23T01:13:14Z cellular_component owl:Class
GO:0048515 biolink:NamedThing spermatid differentiation The process whose specific outcome is the progression of a spermatid over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti spermatid cell differentiation biological_process owl:Class
GO:0021735 biolink:NamedThing dentate nucleus development The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0060173 biolink:NamedThing limb development The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin. got7fsn_ti limb bud development|paired limb/fin development Wikipedia:Limb_development biological_process owl:Class
NCBITaxon:33154 biolink:NamedThing got7fsn_ti owl:Class
GO:0009833 biolink:NamedThing plant-type primary cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana. got7fsn_ti primary cell wall synthesis|primary cell wall formation|primary cell wall biogenesis|primary cell wall anabolism|cellulose and pectin-containing primary cell wall biogenesis|primary cell wall biosynthetic process biological_process owl:Class
GO:0002102 biolink:NamedThing podosome An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm. got7fsn_ti Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. Wikipedia:Podosome cellular_component owl:Class
GO:0004364 biolink:NamedThing glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. got7fsn_ti glutathione S-alkyltransferase activity|glutathione S-aryltransferase activity|glutathione S-aralkyltransferase activity|glutathione S-alkyl transferase activity|RX:glutathione R-transferase activity|glutathione conjugation reaction|glutathione S-transferase activity|S-(hydroxyalkyl)glutathione lyase activity Reactome:R-HSA-9026911|Reactome:R-HSA-9026780|Reactome:R-HSA-9026901|Reactome:R-HSA-5423653|Reactome:R-HSA-3301943|Reactome:R-HSA-9026777|MetaCyc:GSHTRAN-RXN|EC:2.5.1.18|Reactome:R-HSA-176059|Reactome:R-HSA-176054 molecular_function owl:Class
GO:0044284 biolink:NamedThing mitochondrial crista junction A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane. got7fsn_ti cristae junction|crista junction https://github.com/geneontology/go-ontology/issues/18994 jl 2010-02-02T10:07:39Z cellular_component owl:Class
GO:0042675 biolink:NamedThing compound eye cone cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye. got7fsn_ti GO:0042674 biological_process owl:Class
GO:0005030 biolink:NamedThing neurotrophin receptor activity Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0072684 biolink:NamedThing mitochondrial tRNA 3'-trailer cleavage, endonucleolytic Endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA in the mitochondrion. got7fsn_ti mitochondrial endonucleolytic tRNA 3'-end cleavage|mitochondrial tRNA 3'-end cleavage, endonucleolytic|mitochondrial endonucleolytic tRNA 3'-trailer cleavage mah 2011-02-23T01:32:52Z biological_process owl:Class
GO:0061250 biolink:NamedThing mesonephric glomerular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. got7fsn_ti dph 2010-08-30T01:20:03Z biological_process owl:Class
GO:0002910 biolink:NamedThing positive regulation of peripheral B cell deletion Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion. got7fsn_ti up regulation of peripheral B cell deletion|upregulation of peripheral B cell deletion|activation of peripheral B cell deletion|up-regulation of peripheral B cell deletion|stimulation of peripheral B cell deletion biological_process owl:Class
GO:0005933 biolink:NamedThing cellular bud A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated. got7fsn_ti cellular_component owl:Class
GO:0072121 biolink:NamedThing head kidney maturation A developmental process, independent of morphogenetic (shape) change, that is required for the head kidney to attain its fully functional state. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. got7fsn_ti mah 2010-02-22T11:28:08Z biological_process owl:Class
GO:0019208 biolink:NamedThing phosphatase regulator activity Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. got7fsn_ti molecular_function owl:Class
GO:0060797 biolink:NamedThing transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate. got7fsn_ti transforming growth factor beta receptor signalling pathway involved in primary germ layer cell fate commitment dph 2009-08-04T03:41:44Z biological_process owl:Class
GO:0060795 biolink:NamedThing cell fate commitment involved in formation of primary germ layer The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation. got7fsn_ti dph 2009-08-04T03:11:22Z biological_process owl:Class
GO:0070938 biolink:NamedThing contractile ring A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles. got7fsn_ti constriction ring|cytokinetic ring mah 2009-09-22T02:41:32Z cellular_component owl:Class
GO:0070144 biolink:NamedThing mitochondrial arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA in a mitochondrion, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0032865 biolink:NamedThing ERMES complex A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. got7fsn_ti ER-mitochondria encounter structure|mitochore|Mdm10/Mdm12/Mmm1 complex|MMM1 complex cellular_component owl:Class
GO:0000466 biolink:NamedThing maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0045463 biolink:NamedThing R8 cell development The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium. got7fsn_ti biological_process owl:Class
GO:0045465 biolink:NamedThing R8 cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor. got7fsn_ti biological_process owl:Class
GO:0072041 biolink:NamedThing positive regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. got7fsn_ti positive regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis|positive regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis mah 2010-01-25T03:10:32Z biological_process owl:Class
GO:0005342 biolink:NamedThing organic acid transmembrane transporter activity Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. got7fsn_ti molecular_function owl:Class
GO:1903825 biolink:NamedThing organic acid transmembrane transport The process in which an organic acid is transported across a membrane. got7fsn_ti vw 2015-01-20T10:20:58Z biological_process owl:Class
GO:0016325 biolink:NamedThing oocyte microtubule cytoskeleton organization Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte microtubule cytoskeleton organisation GO:0048130 biological_process owl:Class
GO:0070676 biolink:NamedThing intralumenal vesicle formation The invagination of the endosome membrane and resulting formation of a vesicle within the lumen of the endosome. got7fsn_ti endosome membrane budding mah 2009-05-29T02:02:30Z biological_process owl:Class
GO:1904256 biolink:NamedThing positive regulation of iron ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of an iron transmembrane transporter activity. got7fsn_ti up regulation of iron cation channel activity|activation of iron channel activity|up-regulation of iron channel activity|up-regulation of iron-specific channel activity|positive regulation of iron transmembrane transporter activity|upregulation of iron cation channel activity|upregulation of iron channel activity|up-regulation of iron cation channel activity|up regulation of iron channel activity|up regulation of iron-specific channel activity|upregulation of iron-specific channel activity|activation of iron-specific channel activity|positive regulation of iron-specific channel activity|activation of iron cation channel activity|positive regulation of iron channel activity|positive regulation of iron cation channel activity kom 2015-05-20T14:05:12Z biological_process owl:Class
GO:0061804 biolink:NamedThing mitotic spindle formation (spindle phase one) The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase. got7fsn_ti mitotic spindle elongation during mitotic prophase|mitotic spindle elongation during prophase|mitotic spindle elongation during prophase and prometaphase dph 2016-11-06T23:08:01Z biological_process owl:Class
GO:0009863 biolink:NamedThing salicylic acid mediated signaling pathway A series of molecular signals mediated by salicylic acid. got7fsn_ti salicylic acid mediated signal transduction|salicylic acid mediated signalling pathway|salicylic acid-mediated signaling pathway biological_process owl:Class
GO:0071446 biolink:NamedThing cellular response to salicylic acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus. got7fsn_ti cellular response to salicylate stimulus mah 2009-12-16T04:14:16Z biological_process owl:Class
GO:0004709 biolink:NamedThing MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. got7fsn_ti MEK kinase activity|MLK-like mitogen-activated protein triple kinase activity|MLTKb|MAPKKK activity|MEKK|MAP3K|cRaf|ATP:protein phosphotransferase (MAPKKKK-activated) activity|MEKK1|cMos|MAPK/ERK kinase kinase activity|REKS|mitogen-activated protein kinase kinase kinase activity|Mil/Raf|MEKK2|MEKK activity|MLTK|MLTKa|MEKK3|STK28 GO:0004710 Reactome:R-HSA-450346|Reactome:R-HSA-392530|Reactome:R-HSA-451649|Reactome:R-HSA-450337|EC:2.7.11.25|Reactome:R-HSA-933530|Reactome:R-HSA-2730887|Reactome:R-HSA-727819|Reactome:R-HSA-168184|MetaCyc:2.7.11.25-RXN molecular_function owl:Class
GO:0000913 biolink:NamedThing preprophase band assembly The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation. got7fsn_ti preprophase band formation biological_process owl:Class
GO:0002013 biolink:NamedThing detection of carbon dioxide by vasomotor center The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system. got7fsn_ti biological_process owl:Class
GO:0015768 biolink:NamedThing maltose transport The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch. got7fsn_ti biological_process owl:Class
GO:0061234 biolink:NamedThing mesonephric glomerulus morphogenesis The process in which the anatomical structures of the mesonephric glomerulus are generated and organized. The mesonephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate mesonephros. got7fsn_ti dph 2010-08-19T02:53:35Z biological_process owl:Class
GO:0015108 biolink:NamedThing chloride transmembrane transporter activity Enables the transfer of chloride ions from one side of a membrane to the other. got7fsn_ti ATPase-coupled chloride transmembrane transporter activity|chloride ABC transporter|ATP-dependent chloride transmembrane transporter activity|chloride-transporting ATPase activity|chloride transporting ATPase activity|chloride ion transmembrane transporter activity GO:0008555 Reactome:R-HSA-5678992|MetaCyc:3.6.3.11-RXN|Reactome:R-HSA-5678863|Reactome:R-HSA-5678822|RHEA:29823 molecular_function owl:Class
GO:1902476 biolink:NamedThing chloride transmembrane transport The process in which chloride is transported across a membrane. got7fsn_ti bf 2013-10-28T09:44:29Z biological_process owl:Class
GO:1903638 biolink:NamedThing positive regulation of protein insertion into mitochondrial outer membrane Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial outer membrane. got7fsn_ti activation of protein transport into mitochondrial outer membrane|activation of mitochondrial outer membrane protein import|positive regulation of protein import into mitochondrial outer membrane|positive regulation of protein transport into mitochondrial outer membrane|activation of protein import into mitochondrial outer membrane|upregulation of mitochondrial outer membrane protein import|upregulation of protein insertion into mitochondrial outer membrane|up regulation of protein import into mitochondrial outer membrane|activation of protein insertion into mitochondrial outer membrane|up-regulation of protein insertion into mitochondrial outer membrane|up regulation of protein insertion into mitochondrial outer membrane|up-regulation of protein import into mitochondrial outer membrane|upregulation of protein import into mitochondrial outer membrane|upregulation of protein transport into mitochondrial outer membrane|up-regulation of mitochondrial outer membrane protein import|up-regulation of protein transport into mitochondrial outer membrane|up regulation of mitochondrial outer membrane protein import|positive regulation of mitochondrial outer membrane protein import|up regulation of protein transport into mitochondrial outer membrane pga 2014-11-20T15:55:01Z biological_process owl:Class
GO:1905209 biolink:NamedThing positive regulation of cardiocyte differentiation Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation. got7fsn_ti activation of cardiac cell differentiation|up regulation of cardiocyte differentiation|up-regulation of cardiocyte differentiation|positive regulation of heart cell differentiation|up-regulation of cardiac cell differentiation|upregulation of heart cell differentiation|up-regulation of heart cell differentiation|upregulation of cardiocyte differentiation|upregulation of cardiac cell differentiation|activation of heart cell differentiation|positive regulation of cardiac cell differentiation|activation of cardiocyte differentiation|up regulation of cardiac cell differentiation|up regulation of heart cell differentiation bc 2016-06-02T07:20:16Z biological_process owl:Class
GO:0019227 biolink:NamedThing neuronal action potential propagation The propagation of an action potential along an axon, away from the soma. got7fsn_ti biological_process owl:Class
GO:0072172 biolink:NamedThing mesonephric tubule formation The developmental process pertaining to the initial formation of a mesonephric tubule from unspecified parts. A mesonephric tubule is an epithelial tube that is part of the mesonephros. got7fsn_ti mah 2010-02-26T02:02:37Z biological_process owl:Class
GO:0072171 biolink:NamedThing mesonephric tubule morphogenesis The process in which the anatomical structures of a mesonephric tubule are generated and organized. A mesonephric tubule is an epithelial tube that is part of the mesonephros. got7fsn_ti mah 2010-02-26T02:02:13Z biological_process owl:Class
GO:0150018 biolink:NamedThing basal dendrite development The process whose specific outcome is the progression of a basal dendrite over time, from its formation to the mature structure. got7fsn_ti bc 2017-12-22T11:09:53Z biological_process owl:Class
GO:0007453 biolink:NamedThing clypeo-labral disc morphogenesis The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus. got7fsn_ti clypeo-labral disc metamorphosis|morphogenesis of structures derived from the clypeo-labral disc biological_process owl:Class
GO:0060601 biolink:NamedThing lateral sprouting from an epithelium The process in which a branch forms along the side of an epithelium. got7fsn_ti dph 2009-05-14T02:33:01Z biological_process owl:Class
GO:0033550 biolink:NamedThing MAP kinase tyrosine phosphatase activity Catalysis of the reaction: MAP kinase tyrosine phosphate + H2O = MAP kinase tyrosine + phosphate. got7fsn_ti tyrosine-specific MAP kinase phosphatase activity molecular_function owl:Class
GO:1990264 biolink:NamedThing peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity. got7fsn_ti al 2014-01-09T14:28:41Z biological_process owl:Class
GO:0002811 biolink:NamedThing negative regulation of antifungal peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis. got7fsn_ti down regulation of antifungal peptide biosynthetic process|downregulation of antifungal peptide biosynthetic process|down-regulation of antifungal peptide biosynthetic process|inhibition of antifungal peptide biosynthetic process biological_process owl:Class
GO:0048811 biolink:NamedThing male analia morphogenesis The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. got7fsn_ti biological_process owl:Class
GO:0005916 biolink:NamedThing fascia adherens A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes. got7fsn_ti Wikipedia:Fascia_adherens cellular_component owl:Class
GO:0014704 biolink:NamedThing intercalated disc A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. got7fsn_ti intercalated disk Wikipedia:Intercalated_disc cellular_component owl:Class
GO:1904858 biolink:NamedThing negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. got7fsn_ti inhibition of endothelial cell chemotaxis to vascular endothelial growth factor|down-regulation of endothelial cell chemotaxis to vascular endothelial growth factor|downregulation of endothelial cell chemotaxis to vascular endothelial growth factor|down regulation of endothelial cell chemotaxis to vascular endothelial growth factor rph 2015-12-16T11:47:52Z biological_process owl:Class
GO:1903089 biolink:NamedThing 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity Enables the transfer of 5-amino-1-ribofuranosylimidazole-4-carboxamide from one side of a membrane to the other. got7fsn_ti acadesine transporter activity mcc 2014-06-02T20:37:17Z molecular_function owl:Class
GO:1903088 biolink:NamedThing 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport The process in which 5-amino-1-ribofuranosylimidazole-4-carboxamide is transported across a membrane. got7fsn_ti mcc 2014-06-02T20:34:58Z biological_process owl:Class
GO:0071018 biolink:NamedThing U12-type catalytic step 2 spliceosome A spliceosomal complex that contains the U12, U5 and U6atac snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U12, U5 and U6atac snRNPs. got7fsn_ti minor catalytic step 2 spliceosome|mammalian U12-type spliceosomal complex C1|yeast U12-type spliceosomal complex A2-2|mammalian U12-type spliceosomal complex C|AT-AC catalytic step 2 spliceosome mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0021528 biolink:NamedThing commissural neuron differentiation in spinal cord The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0140014 biolink:NamedThing mitotic nuclear division A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. got7fsn_ti mitosis https://github.com/geneontology/go-ontology/issues/19910 pg 2017-03-23T14:44:23Z biological_process owl:Class
GO:1990676 biolink:NamedThing Golgi trans cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex. got7fsn_ti trans-Golgi cisterna membrane bhm 2015-03-02T11:53:35Z cellular_component owl:Class
GO:0097568 biolink:NamedThing median body A non-membrane bound, semi-organized microtubule array of unknown function found in Giardia species (trophozoite stage). It is located on the dorsal side of the trophozoite, slightly posterior to the ventral disc. got7fsn_ti parabasal body Note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-11T13:34:19Z cellular_component owl:Class
GO:0009657 biolink:NamedThing plastid organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid. got7fsn_ti plastid organization and biogenesis|plastid organisation biological_process owl:Class
GO:0009516 biolink:NamedThing leucoplast A colorless plastid involved in the synthesis of monoterpenes. got7fsn_ti Wikipedia:Leucoplast cellular_component owl:Class
GO:0007585 biolink:NamedThing respiratory gaseous exchange by respiratory system The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. got7fsn_ti respiration|breathing biological_process owl:Class
GO:0031595 biolink:NamedThing nuclear proteasome complex A proteasome found in the nucleus of a cell. got7fsn_ti cellular_component owl:Class
GO:1990499 biolink:NamedThing raps-insc complex Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2). got7fsn_ti Rapsynoid-Inscuteable complex|partner of inscuteable-inscuteable complex An example of this is Insc in drome (Q9W2R4) in PMID:22171003 (inferred from physical interaction). bhm 2014-09-30T09:22:18Z cellular_component owl:Class
GO:0060674 biolink:NamedThing placenta blood vessel development The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure. got7fsn_ti dph 2009-06-02T01:09:43Z biological_process owl:Class
GO:0008137 biolink:NamedThing NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out). got7fsn_ti coenzyme Q reductase activity|NADH-CoQ oxidoreductase activity|NADH-ubiquinone oxidoreductase activity|DPNH-coenzyme Q reductase activity|NADH-ubiquinone reductase activity|mitochondrial electron transport complex 1 activity|dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity|NADH-coenzyme Q reductase activity|complex I (mitochondrial electron transport) activity|complex I (electron transport chain) activity|NADH-ubiquinone-1 reductase activity|ubiquinone reductase activity|DPNH-ubiquinone reductase activity|electron transfer complex I activity|reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity|NADH:ubiquinone oxidoreductase activity|mitochondrial electron transport complex I activity|NADH-Q6 oxidoreductase activity|type 1 dehydrogenase activity|NADH:ubiquinone oxidoreductase complex activity|complex I (NADH:Q1 oxidoreductase) activity|NADH coenzyme Q1 reductase activity|NADH-coenzyme Q oxidoreductase activity|complex 1 dehydrogenase activity|NADH-CoQ reductase activity https://github.com/geneontology/go-ontology/issues/21275|https://github.com/geneontology/go-ontology/issues/20616 MetaCyc:NADH-DEHYDROG-A-RXN|MetaCyc:RXN0-5330|EC:7.1.1.2|Reactome:R-HSA-163217|RHEA:29091 molecular_function owl:Class
GO:0016079 biolink:NamedThing synaptic vesicle exocytosis Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. got7fsn_ti biological_process owl:Class
GO:1901992 biolink:NamedThing positive regulation of mitotic cell cycle phase transition Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition. got7fsn_ti up-regulation of mitotic cell cycle phase transition|upregulation of mitotic cell cycle phase transition|activation of mitotic cell cycle phase transition|up regulation of mitotic cell cycle phase transition jl 2013-03-19T16:14:51Z biological_process owl:Class
GO:0004136 biolink:NamedThing deoxyadenosine kinase activity Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+). got7fsn_ti deoxyadenosine kinase (phosphorylating)|purine-deoxyribonucleoside kinase activity|ATP:deoxyadenosine 5'-phosphotransferase activity MetaCyc:DEOXYADENOSINE-KINASE-RXN|KEGG_REACTION:R02089|RHEA:23452|EC:2.7.1.76 molecular_function owl:Class
GO:0006170 biolink:NamedThing dAMP biosynthetic process The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate). got7fsn_ti dAMP synthesis|dAMP anabolism|dAMP formation|dAMP biosynthesis biological_process owl:Class
GO:0042438 biolink:NamedThing melanin biosynthetic process The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. got7fsn_ti melanin biosynthesis|melanin formation|melanin synthesis|melanin anabolism biological_process owl:Class
GO:0031986 biolink:NamedThing proteinoplast A leucoplast in which protein is stored. got7fsn_ti Wikipedia:Proteinoplast cellular_component owl:Class
GO:0048388 biolink:NamedThing endosomal lumen acidification Any process that reduces the pH of the endosomal lumen, measured by the concentration of the hydrogen ion. got7fsn_ti biological_process owl:Class
GO:0007032 biolink:NamedThing endosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes. got7fsn_ti endosome organization and biogenesis|endosome organisation biological_process owl:Class
GO:0007282 biolink:NamedThing cystoblast division Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells. got7fsn_ti cystoblast cell division biological_process owl:Class
GO:0048891 biolink:NamedThing lateral line ganglion neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron. got7fsn_ti gLL neuron differentiation biological_process owl:Class
GO:0021692 biolink:NamedThing cerebellar Purkinje cell layer morphogenesis The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. got7fsn_ti biological_process owl:Class
GO:0021696 biolink:NamedThing cerebellar cortex morphogenesis The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. got7fsn_ti biological_process owl:Class
GO:0033174 biolink:NamedThing chloroplast proton-transporting ATP synthase complex, catalytic core CF(1) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits. got7fsn_ti chloroplast proton-transporting F-type ATPase complex, catalytic core CF(1) cellular_component owl:Class
GO:2000595 biolink:NamedThing regulation of optic nerve formation Any process that modulates the frequency, rate or extent of optic nerve formation. got7fsn_ti regulation of CN II biosynthesis|regulation of CN II formation yaf 2011-04-11T03:41:30Z biological_process owl:Class
GO:0042151 biolink:NamedThing nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. got7fsn_ti cnidocyst Wikipedia:Cnidocyte cellular_component owl:Class
GO:0043188 biolink:NamedThing cell septum edging The cell wall material that surrounds the septum in fungal cells. got7fsn_ti cellular_component owl:Class
GO:0045120 biolink:NamedThing pronucleus The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents. got7fsn_ti Wikipedia:Pronucleus cellular_component owl:Class
GO:0003144 biolink:NamedThing embryonic heart tube formation The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart. got7fsn_ti tb 2009-09-22T04:22:34Z biological_process owl:Class
GO:1902375 biolink:NamedThing nuclear tRNA 3'-trailer cleavage, endonucleolytic Any tRNA 3'-trailer cleavage, endonucleolytic that takes place in nucleus. got7fsn_ti endonucleolytic tRNA 3'-trailer cleavage in cell nucleus|tRNA 3'-trailer cleavage, endonucleolytic in cell nucleus|tRNA 3'-end cleavage, endonucleolytic in cell nucleus|endonucleolytic tRNA 3'-end cleavage in nucleus|endonucleolytic tRNA 3'-end cleavage in cell nucleus|endonucleolytic tRNA 3'-trailer cleavage in nucleus|tRNA 3'-end cleavage, endonucleolytic in nucleus al 2013-08-30T09:17:30Z biological_process owl:Class
GO:0032231 biolink:NamedThing regulation of actin filament bundle assembly Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles. got7fsn_ti regulation of actin cable assembly|regulation of actin filament bundle formation biological_process owl:Class
GO:0043600 biolink:NamedThing cytoplasmic replisome A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins. got7fsn_ti prokaryotic replisome cellular_component owl:Class
GO:0043597 biolink:NamedThing cytoplasmic replication fork The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. got7fsn_ti cellular_component owl:Class
GO:0005897 biolink:NamedThing interleukin-9 receptor complex A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins. got7fsn_ti IL-9 receptor complex cellular_component owl:Class
GO:0035050 biolink:NamedThing embryonic heart tube development The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field. got7fsn_ti biological_process owl:Class
GO:0035876 biolink:NamedThing maintenance of meiotic sister chromatid cohesion, arms The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. got7fsn_ti maintenance of sister chromatin cohesion along arms at meiosis I|maintenance of meiotic sister chromatin cohesion along arms bf 2011-05-31T09:37:53Z biological_process owl:Class
GO:0051760 biolink:NamedThing meiotic sister chromatid cohesion, arms The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis. got7fsn_ti sister chromatid cohesion along arms at meiosis I|meiotic sister chromatid cohesion along arms biological_process owl:Class
GO:0150004 biolink:NamedThing dendritic spine origin The part of the dendritic spine neck where the spine arises from the dendritic shaft. got7fsn_ti cellular_component owl:Class
GO:0015694 biolink:NamedThing mercury ion transport The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti mercuric ion transport|mercury transport biological_process owl:Class
GO:0050787 biolink:NamedThing detoxification of mercury ion Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0]). got7fsn_ti biological_process owl:Class
GO:0039669 biolink:NamedThing viral entry into host cell via pilus retraction and membrane fusion The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane. got7fsn_ti For annotation of viral pilus-binding proteins, see also 'viral attachment to host cell pilus ; GO:0039666'. bf 2013-09-04T14:35:44Z biological_process owl:Class
GO:0019064 biolink:NamedThing fusion of virus membrane with host plasma membrane Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm. got7fsn_ti viral envelope fusion with host cell membrane|viral-cell fusion molecule activity|viral penetration via membrane fusion|viral envelope fusion with host plasma membrane|viral entry into host cell via membrane fusion with the plasma membrane|viral envelope fusion|viral envelope fusion with host membrane GO:0075706 VZ:987 biological_process owl:Class
GO:0043596 biolink:NamedThing nuclear replication fork The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. got7fsn_ti cellular_component owl:Class
GO:0071162 biolink:NamedThing CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. got7fsn_ti unwindosome mah 2009-11-19T11:04:13Z cellular_component owl:Class
GO:1902668 biolink:NamedThing negative regulation of axon guidance Any process that stops, prevents or reduces the frequency, rate or extent of axon guidance. got7fsn_ti downregulation of axon pathfinding|down-regulation of axon guidance|down regulation of axon growth cone guidance|down-regulation of axon chemotaxis|down-regulation of axon growth cone guidance|downregulation of axon chemotaxis|negative regulation of axon chemotaxis|down regulation of axon chemotaxis|negative regulation of axon growth cone guidance|downregulation of axon guidance|inhibition of axon pathfinding|downregulation of axon growth cone guidance|negative regulation of axon pathfinding|down-regulation of axon pathfinding|inhibition of axon growth cone guidance|inhibition of axon guidance|down regulation of axon guidance|inhibition of axon chemotaxis|down regulation of axon pathfinding hjd 2014-01-31T18:50:19Z biological_process owl:Class
GO:0097654 biolink:NamedThing platelet SNARE complex A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4. got7fsn_ti pr 2014-09-24T13:50:49Z cellular_component owl:Class
GO:0098908 biolink:NamedThing regulation of neuronal action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti generation of action potential biological_process owl:Class
GO:0005031 biolink:NamedThing tumor necrosis factor-activated receptor activity Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. got7fsn_ti tumor necrosis factor receptor activity, type I|NGF/TNF (6 C-domain) receptor activity|TNF receptor activity|TNF receptor activity, type II|tumor necrosis factor receptor activity, type II|TNF receptor activity, type I|tumor necrosis factor receptor activity GO:0005032|GO:0005033 molecular_function owl:Class
GO:1990176 biolink:NamedThing MalFGK2 complex Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG. got7fsn_ti MalF-MalG-MalK-MalK complex|maltose transport MalFGK2 complex|MalF-MalG-MalK(2) complex|MalFGK(2) complex|maltose transport complex, core subunit The MalFGK2 complex lacks the maltose-binding subunit present in GO:1990060. bhm 2013-08-30T11:10:14Z cellular_component owl:Class
GO:0014705 biolink:NamedThing C zone A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin. got7fsn_ti cellular_component owl:Class
GO:0043292 biolink:NamedThing contractile fiber Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. got7fsn_ti contractile fibre cellular_component owl:Class
GO:0033080 biolink:NamedThing immature T cell proliferation in thymus The expansion of an immature T cell population by cell division in the thymus. got7fsn_ti thymocyte proliferation|thymocyte cell proliferation|thymic T cell proliferation biological_process owl:Class
GO:0033077 biolink:NamedThing T cell differentiation in thymus The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus. got7fsn_ti T cell development in thymus|thymic T cell differentiation|thymocyte cell differentiation|thymocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0120003 biolink:NamedThing hinge region between urothelial plaques of apical plasma membrane A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane. got7fsn_ti https://github.com/geneontology/go-ontology/issues/12996 krc 2017-02-23T22:13:27Z cellular_component owl:Class
GO:0016324 biolink:NamedThing apical plasma membrane The region of the plasma membrane located at the apical end of the cell. got7fsn_ti cellular_component owl:Class
GO:0048600 biolink:NamedThing oocyte fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an oocyte. got7fsn_ti biological_process owl:Class
GO:0030970 biolink:NamedThing retrograde protein transport, ER to cytosol The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon. got7fsn_ti retrograde protein transport, endoplasmic reticulum to cytosol|protein retrotranslocation, ER to cytosol|protein dislocation from ER biological_process owl:Class
GO:0048840 biolink:NamedThing otolith development The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0016189 biolink:NamedThing synaptic vesicle to endosome fusion Fusion of a synaptic vesicle with an endosome. got7fsn_ti This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. biological_process owl:Class
GO:0099532 biolink:NamedThing synaptic vesicle endosomal processing The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. got7fsn_ti synaptic vesicle processing via endosome This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. biological_process owl:Class
GO:0030204 biolink:NamedThing chondroitin sulfate metabolic process The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate. got7fsn_ti chondroitin sulphate metabolic process|chondroitin sulfate metabolism|chondroitin sulphate metabolism biological_process owl:Class
GO:0030222 biolink:NamedThing eosinophil differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil. got7fsn_ti eosinophil cell development|eosinophil development|eosinophil cell differentiation GO:0035856 biological_process owl:Class
GO:1990669 biolink:NamedThing endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. got7fsn_ti ER-Golgi intermediate compartment derived vesicle fusion with ER membrane|endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with ER membrane bhm 2015-03-02T11:21:43Z biological_process owl:Class
GO:0006890 biolink:NamedThing retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. got7fsn_ti retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum|retrograde vesicle-mediated transport, Golgi to ER|cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport|cis-Golgi to rough endoplasmic reticulum transport|cis-Golgi to rough ER transport|cis-Golgi to rough ER vesicle-mediated transport|retrograde transport, Golgi to ER|retrograde transport, Golgi to endoplasmic reticulum|retrograde (Golgi to ER) transport GO:0048220 biological_process owl:Class
GO:1990657 biolink:NamedThing iNOS-S100A8/A9 complex A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine. got7fsn_ti An example of this is NOS2 in human (UniProt symbol P35228) in PMID:25417112 (inferred from direct assay). bhm 2015-02-25T11:00:49Z cellular_component owl:Class
GO:0009876 biolink:NamedThing pollen adhesion The process in which pollen deposited on the stigma adheres to cells of the stigma. got7fsn_ti biological_process owl:Class
GO:0002810 biolink:NamedThing regulation of antifungal peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis. got7fsn_ti biological_process owl:Class
GO:0097618 biolink:NamedThing dinoflagellate sulcal notch A dinoflagellate sulcus that extends all the way to the posterior end of the cell (also known as antapex). The presence of a sulcal notch makes the dinoflagellate hypocone appear bilobed. got7fsn_ti dinoflagellate sulcus notch|sulcal notch The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. Also, the ventral (front) side of a dinoflagellate cell is the one where the sulcus is located (as opposed to the dorsal (back) side). The term 'sulcal notch' appears mostly in older literature; more recently, indication of a bilobed hypocone is used to express the same. pr 2014-06-27T16:28:49Z cellular_component owl:Class
GO:0062159 biolink:NamedThing contractile vacuole complex A non-membrane-bounded organelle of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally. One of its functions is osmoregulatory. got7fsn_ti CVC dph 2019-09-26T14:20:14Z cellular_component owl:Class
GO:0043054 biolink:NamedThing dauer exit Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development. got7fsn_ti exit from nematode dormancy biological_process owl:Class
GO:0048625 biolink:NamedThing myoblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0045445 biolink:NamedThing myoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. got7fsn_ti myoblast cell differentiation biological_process owl:Class
GO:0061639 biolink:NamedThing Cdv-dependent cytokinesis A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells. got7fsn_ti dph 2014-08-21T14:55:04Z biological_process owl:Class
NCBITaxon:2157 biolink:NamedThing got7fsn_ti owl:Class
GO:0048616 biolink:NamedThing post-embryonic anterior midgut (ectodermal) morphogenesis The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized, during the post-embryonic phase. got7fsn_ti biological_process owl:Class
GO:0000457 biolink:NamedThing endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. got7fsn_ti biological_process owl:Class
GO:0002109 biolink:NamedThing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0048741 biolink:NamedThing skeletal muscle fiber development The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. got7fsn_ti skeletal myofibre development|skeletal myofiber development|skeletal muscle fibre development biological_process owl:Class
GO:0007519 biolink:NamedThing skeletal muscle tissue development The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers. got7fsn_ti myogenesis GO:0048637 biological_process owl:Class
GO:0099534 biolink:NamedThing calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations. got7fsn_ti presynaptic calcium ion buffering|calcium ion binding involved in regulation of presynaptic cytosolic calcium levels|regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering molecular_function owl:Class
GO:0099523 biolink:NamedThing presynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the presynapse. got7fsn_ti cellular_component owl:Class
GO:0019933 biolink:NamedThing cAMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. got7fsn_ti adenosine 3',5'-cyclophosphate-mediated signalling|cyclic AMP-mediated signaling|3',5' cAMP-mediated signaling|cAMP-mediated signal transduction|3',5'-cAMP-mediated signaling|cAMP-mediated signalling|adenosine 3',5'-cyclophosphate-mediated signaling|3',5' cAMP-mediated signalling|cAMP signaling|3',5'-cAMP-mediated signalling|cAMP signalling|cyclic AMP-mediated signalling biological_process owl:Class
GO:0061298 biolink:NamedThing retina vasculature development in camera-type eye The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure. got7fsn_ti retinal vasculature development dph 2010-09-06T03:27:06Z biological_process owl:Class
GO:0010824 biolink:NamedThing regulation of centrosome duplication Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. got7fsn_ti biological_process owl:Class
GO:0043588 biolink:NamedThing skin development The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. got7fsn_ti animal skin development biological_process owl:Class
GO:0061113 biolink:NamedThing pancreas morphogenesis Morphogenesis of the pancreas. Morphogenesis is the process in which anatomical structures are generated and organized. got7fsn_ti dph 2010-05-05T11:55:30Z biological_process owl:Class
GO:0031016 biolink:NamedThing pancreas development The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes. got7fsn_ti Wikipedia:Pancreas biological_process owl:Class
GO:0000027 biolink:NamedThing ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. got7fsn_ti 60S ribosomal subunit assembly|50S ribosomal subunit assembly biological_process owl:Class
GO:0042273 biolink:NamedThing ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. got7fsn_ti ribosomal large subunit biogenesis and assembly biological_process owl:Class
GO:0048222 biolink:NamedThing glycoprotein network An extracellular matrix part that consists of cross-linked glycoproteins. got7fsn_ti extensin Wikipedia:Extensin cellular_component owl:Class
GO:1990565 biolink:NamedThing HSP90-CDC37 chaperone complex A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signalling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins. got7fsn_ti An example of this is HSP90AB1 in human (UniProt symbol P08238) in PMID:21855797 (inferred from direct assay). bhm 2014-11-26T14:22:51Z cellular_component owl:Class
GO:0016591 biolink:NamedThing RNA polymerase II, holoenzyme A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters. got7fsn_ti DNA-directed RNA polymerase II, holoenzyme cellular_component owl:Class
GO:0061724 biolink:NamedThing lipophagy The selective autophagy process in which lipid droplets are delivered to the vacuole and degraded in response to changing cellular conditions. got7fsn_ti dph 2015-07-08T13:38:19Z biological_process owl:Class
GO:1905691 biolink:NamedThing lipid droplet disassembly The disaggregation of a lipid particle into its constituent components. got7fsn_ti lipid body disassembly|lipid droplet reserve breakdown|lipid particle disassembly|adiposome disassembly pr 2016-11-14T13:39:06Z biological_process owl:Class
GO:0050786 biolink:NamedThing RAGE receptor binding Binding to a RAGE receptor, the receptor for advanced glycation end-products. got7fsn_ti advanced glycation end-product receptor binding molecular_function owl:Class
GO:0048686 biolink:NamedThing regulation of sprouting of injured axon Any process that modulates the frequency, rate or extent of sprouting of an injured axon. got7fsn_ti biological_process owl:Class
GO:2000121 biolink:NamedThing regulation of removal of superoxide radicals Any process that modulates the frequency, rate or extent of removal of superoxide radicals. got7fsn_ti regulation of removal of oxygen free radicals|regulation of removal of O2- dhl 2010-09-27T05:30:37Z biological_process owl:Class
GO:0000302 biolink:NamedThing response to reactive oxygen species Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. got7fsn_ti response to ROI|response to AOS|response to reactive oxidative species|response to ROS|response to reactive oxygen intermediate|response to active oxygen species biological_process owl:Class
GO:0048224 biolink:NamedThing lignin network An extracellular matrix part that consists of lignin in the form of a three-dimensional polymeric network. Lignins are complex racemic aromatic heteropolymers derived from a variety of phenylpropane monomers coupled together by an assortment of carbon-carbon and ether linkages. Lignin is crucial for structural integrity of the cell wall and stiffness and strength of the stem. In addition, lignin waterproofs the cell wall, enabling transport of water and solutes through the vascular system, and plays a role in protecting plants against pathogens. got7fsn_ti cellular_component owl:Class
GO:0009531 biolink:NamedThing secondary cell wall A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin. got7fsn_ti Wikipedia:Secondary_cell_wall cellular_component owl:Class
GO:0070151 biolink:NamedThing mitochondrial histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA in a mitochondrion, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:1905790 biolink:NamedThing regulation of mechanosensory behavior Any process that modulates the frequency, rate or extent of mechanosensory behavior. got7fsn_ti regulation of behavioral response to mechanical stimulus|regulation of mechanosensory behaviour|regulation of behavioural response to mechanical stimulus hbye 2017-01-09T15:17:07Z biological_process owl:Class
GO:0002916 biolink:NamedThing positive regulation of central B cell anergy Any process that activates or increases the frequency, rate, or extent of central B cell anergy. got7fsn_ti up-regulation of central B cell anergy|up regulation of central B cell anergy|activation of central B cell anergy|upregulation of central B cell anergy|stimulation of central B cell anergy biological_process owl:Class
GO:0061551 biolink:NamedThing trigeminal ganglion development The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. got7fsn_ti trigeminal ganglia development dph 2013-07-10T08:42:19Z biological_process owl:Class
GO:0035400 biolink:NamedThing histone tyrosine kinase activity Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. got7fsn_ti histone-tyrosine kinase activity bf 2010-03-24T09:59:15Z molecular_function owl:Class
GO:0035406 biolink:NamedThing histone-tyrosine phosphorylation The modification of histones by addition of a phosphate group to a tyrosine residue. got7fsn_ti histone tyrosine phosphorylation bf 2010-03-24T10:10:16Z biological_process owl:Class
GO:0048618 biolink:NamedThing post-embryonic foregut morphogenesis The process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase. got7fsn_ti biological_process owl:Class
GO:0021636 biolink:NamedThing trigeminal nerve morphogenesis The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. got7fsn_ti CN V morphogenesis biological_process owl:Class
GO:0140690 biolink:NamedThing dihydropyrimidine dehydrogenase (NAD+) complex A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21891 pg 2021-08-04T05:52:44Z MetaCyc:CPLX0-7788 cellular_component owl:Class
GO:0071331 biolink:NamedThing cellular response to hexose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. got7fsn_ti mah 2009-12-10T05:37:00Z biological_process owl:Class
GO:0045873 biolink:NamedThing negative regulation of sevenless signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway. got7fsn_ti negative regulation of sev signaling pathway|down-regulation of sevenless signaling pathway|inhibition of sevenless signaling pathway|negative regulation of sevenless signalling pathway|down regulation of sevenless signaling pathway|downregulation of sevenless signaling pathway biological_process owl:Class
GO:0033569 biolink:NamedThing lactoferrin transmembrane transporter activity Enables the transfer of lactoferrin from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0062000 biolink:NamedThing positive regulation of cardiac endothelial to mesenchymal transition Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal trnasition. got7fsn_ti dph 2018-02-16T16:31:06Z biological_process owl:Class
GO:0120268 biolink:NamedThing paraflagellar rod assembly The aggregation, arrangement and bonding together of a set of components to form a paraflagellar rod, a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. got7fsn_ti PFR assembly|paraflagellar rod formation|paraflagellar rod biogenesis https://github.com/geneontology/go-ontology/issues/20053 krc 2020-09-30T17:46:14Z biological_process owl:Class
NCBITaxon:33682 biolink:NamedThing got7fsn_ti owl:Class
GO:0005302 biolink:NamedThing L-tyrosine transmembrane transporter activity Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid. got7fsn_ti L-tyrosine permease activity|L-tyrosine transporter activity|valine/tyrosine/tryptophan permease activity GO:0015508 molecular_function owl:Class
GO:0015828 biolink:NamedThing tyrosine transport The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-tyrosine transport biological_process owl:Class
GO:0060541 biolink:NamedThing respiratory system development The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange. got7fsn_ti dph 2009-04-10T08:55:42Z biological_process owl:Class
GO:0000486 biolink:NamedThing cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0120216 biolink:NamedThing matrilin complex A cartilage extracellular matrix complex that mediates interactions between major components of the extracellular matrix such as collagens and proteoglycans and contributes to their fibrillar network. Exists as an obligate homotrimer. got7fsn_ti matrilin-1 complex|matrilin-4 complex|matrilin family complex|matrilin-3 complex|matrilin-2 complex krc 2019-07-09T22:05:11Z cellular_component owl:Class
GO:0000914 biolink:NamedThing phragmoplast assembly The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles). got7fsn_ti phragmoplast formation biological_process owl:Class
GO:0001073 biolink:NamedThing transcription antitermination factor activity, DNA binding Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein. got7fsn_ti DNA binding transcription antitermination factor activity krc 2010-10-21T05:18:52Z molecular_function owl:Class
GO:0048867 biolink:NamedThing stem cell fate determination The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0048865 biolink:NamedThing stem cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell. got7fsn_ti biological_process owl:Class
GO:0005290 biolink:NamedThing L-histidine transmembrane transporter activity Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. got7fsn_ti histidine/arginine/lysine/ornithine porter activity|L-histidine transporter activity molecular_function owl:Class
GO:0089709 biolink:NamedThing L-histidine transmembrane transport The directed movement of L-histidine across a membrane. got7fsn_ti biological_process owl:Class
GO:0014044 biolink:NamedThing Schwann cell development The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. got7fsn_ti biological_process owl:Class
GO:0008320 biolink:NamedThing protein transmembrane transporter activity Enables the transfer of a protein from one side of a membrane to the other. got7fsn_ti protein channel activity GO:0015463|GO:0015266 Reactome:R-HSA-5250616|Reactome:R-HSA-5210947|Reactome:R-HSA-5244506|Reactome:R-HSA-1299475|Reactome:R-HSA-5229111|Reactome:R-HSA-5244428|Reactome:R-HSA-5205661|Reactome:R-HSA-5250972|Reactome:R-HSA-3149434|Reactome:R-HSA-9698930|Reactome:R-HSA-1268022|Reactome:R-HSA-5210943|Reactome:R-HSA-5246514|Reactome:R-HSA-9698933|Reactome:R-HSA-5244404|Reactome:R-HSA-5228406|Reactome:R-HSA-184269|Reactome:R-HSA-5336420|Reactome:R-HSA-9636375|Reactome:R-HSA-5250884 molecular_function owl:Class
GO:0048507 biolink:NamedThing meristem development The process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0014801 biolink:NamedThing longitudinal sarcoplasmic reticulum The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae. got7fsn_ti cellular_component owl:Class
GO:0016529 biolink:NamedThing sarcoplasmic reticulum A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage. got7fsn_ti See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'. GO:0008221 Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum cellular_component owl:Class
GO:0043541 biolink:NamedThing UDP-N-acetylglucosamine transferase complex A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis. got7fsn_ti See also the molecular function term 'N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity ; GO:0004577'. cellular_component owl:Class
GO:0090201 biolink:NamedThing negative regulation of release of cytochrome c from mitochondria Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. got7fsn_ti The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process. tb 2009-12-18T11:35:20Z biological_process owl:Class
GO:1990765 biolink:NamedThing colon smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum. got7fsn_ti sl 2015-06-10T18:29:21Z biological_process owl:Class
GO:0008135 biolink:NamedThing translation factor activity, RNA binding Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. got7fsn_ti translation factor activity, nucleic acid binding molecular_function owl:Class
GO:0003336 biolink:NamedThing corneocyte desquamation The delamination process that results in the shedding of a corneocyte from the surface of the epidermis. got7fsn_ti epidermal desquamation dph 2009-11-24T09:11:53Z biological_process owl:Class
GO:0003335 biolink:NamedThing corneocyte development The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis. got7fsn_ti dph 2009-11-24T09:01:02Z biological_process owl:Class
GO:0021613 biolink:NamedThing facial nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. got7fsn_ti CN VII maturation biological_process owl:Class
GO:0021561 biolink:NamedThing facial nerve development The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. got7fsn_ti cranial nerve 7 development|CN VII development|cranial nerve VII development biological_process owl:Class
GO:0035462 biolink:NamedThing determination of left/right asymmetry in diencephalon The establishment of the diencephalon with respect to the left and right halves. got7fsn_ti bf 2010-04-19T11:50:11Z biological_process owl:Class
GO:0031606 biolink:NamedThing cytosolic proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex. got7fsn_ti cellular_component owl:Class
GO:0009841 biolink:NamedThing mitochondrial endopeptidase Clp complex A Clp endopeptidase complex located in the mitochondrion. got7fsn_ti cellular_component owl:Class
GO:0044308 biolink:NamedThing axonal spine A spine that originates from the axon, usually from the initial segment. got7fsn_ti axon spine jl 2010-02-05T04:22:13Z NIF_Subcellular:sao18239917 cellular_component owl:Class
GO:0048197 biolink:NamedThing Golgi membrane coat protein complex assembly The aggregation, arrangement and bonding together of priming complexes to form a coat on a Golgi membrane. Priming complexes associate laterally and additional coat proteins are recruited from the cytosol to the forming coat. Cargo proteins diffuse into the budding site and become trapped by their interactions with the coat. got7fsn_ti Golgi membrane bud coat oligomerisation|dictyosome membrane bud coat oligomerisation|dictyosome membrane binding by cytosolic coat proteins biological_process owl:Class
GO:0021580 biolink:NamedThing medulla oblongata formation The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. got7fsn_ti medulla biosynthesis|medulla formation|myelencephalon formation|myelencephalon biosynthesis biological_process owl:Class
GO:0001959 biolink:NamedThing regulation of cytokine-mediated signaling pathway Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway. got7fsn_ti regulation of cytokine and chemokine mediated signaling pathway|regulation of cytokine mediated signalling pathway|regulation of cytokine mediated signaling pathway biological_process owl:Class
CL:0000210 biolink:NamedThing got7fsn_ti owl:Class
GO:0004385 biolink:NamedThing guanylate kinase activity Catalysis of the reaction: ATP + GMP = ADP + GDP. got7fsn_ti guanosine monophosphate kinase activity|GMP kinase activity|ATP:GMP phosphotransferase activity|ATP:(d)GMP phosphotransferase activity|5'-GMP kinase activity|deoxyguanylate kinase activity|membrane-associated guanylate kinase EC:2.7.4.8|Reactome:R-HSA-73788|MetaCyc:GUANYL-KIN-RXN|RHEA:20780|Reactome:R-HSA-110133 molecular_function owl:Class
GO:0046037 biolink:NamedThing GMP metabolic process The chemical reactions and pathways involving GMP, guanosine monophosphate. got7fsn_ti GMP metabolism biological_process owl:Class
GO:0035807 biolink:NamedThing positive regulation of blood coagulation in other organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot. got7fsn_ti positive regulation of blood clotting in other organism|positive regulation by organism of blood coagulation in other organism|positive regulation by organism of blood clotting in other organism bf 2011-04-20T11:43:37Z biological_process owl:Class
GO:0090489 biolink:NamedThing L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating) Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O. got7fsn_ti tryptophan N-monooxygenase activity tb 2012-10-16T16:22:19Z molecular_function owl:Class
GO:0071404 biolink:NamedThing cellular response to low-density lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. got7fsn_ti response to low-density lipoprotein particle stimulus|response to low-density lipoprotein particle|response to low density lipoprotein particle mah 2009-12-14T02:51:57Z GO:0055098 biological_process owl:Class
GO:0043196 biolink:NamedThing varicosity Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. got7fsn_ti cellular_component owl:Class
GO:0015106 biolink:NamedThing bicarbonate transmembrane transporter activity Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. got7fsn_ti RHEA:28695|Reactome:R-HSA-2752067 molecular_function owl:Class
GO:0015701 biolink:NamedThing bicarbonate transport The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0098962 biolink:NamedThing regulation of postsynaptic neurotransmitter receptor activity Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. got7fsn_ti biological_process owl:Class
GO:0044645 biolink:NamedThing modulation of complement activation in other organism A process that modulates the frequency, rate or extent of complement activation in a different organism. got7fsn_ti regulation of complement activation in other organism jl 2012-07-11T12:37:50Z biological_process owl:Class
GO:0072213 biolink:NamedThing metanephric capsule development The process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. got7fsn_ti mah 2010-03-18T01:25:19Z biological_process owl:Class
GO:0016080 biolink:NamedThing synaptic vesicle targeting The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. got7fsn_ti biological_process owl:Class
GO:0006880 biolink:NamedThing intracellular sequestering of iron ion The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system. got7fsn_ti intracellular iron ion storage|intracellular retention of iron ion|intracellular iron ion sequestration|intracellular iron ion sequestering|intracellular iron ion retention|intracellular storage of iron ion|intracellular sequestration of iron ion biological_process owl:Class
GO:0097565 biolink:NamedThing right middle basal body pair Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally. got7fsn_ti Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T16:14:05Z cellular_component owl:Class
GO:1902674 biolink:NamedThing right posteriolateral basal body Any ciliary basal body that is part of a right posteriolateral flagellum found in Giardia species (trophozoite stage). got7fsn_ti microtubule basal body of right posterolateral cilium|cilium basal body of right posterolateral flagellum|cilial basal body of right posteriolateral flagellum|right posteriolateral flagellum ciliary basal body|ciliary basal body of right posterolateral flagellum|microtubule basal body of right posterolateral flagellum|cilium basal body of right posteriolateral flagellum|cilium basal body of right posteriolateral cilium|cilial basal body of right posterolateral flagellum|ciliary basal body of right posterolateral cilium|cilial basal body of right posteriolateral cilium|microtubule basal body of right posteriolateral cilium|microtubule basal body of right posteriolateral flagellum|ciliary basal body of right posteriolateral cilium|cilium basal body of right posterolateral cilium|cilial basal body of right posterolateral cilium|ciliary basal body of right posteriolateral flagellum Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T14:52:04Z cellular_component owl:Class
GO:0140676 biolink:NamedThing oscillatory cAMP signaling Fluctuation in the extracellular cAMP levels due to the alternate activation of adenylate cyclase, which produces cAMP, and phosphodiesterase, which degrades it. Occurs in Dictyostelium during early sorocarp development. Oscillation in signaling result is directional chemotaxis of cells towards the center of the aggregate. got7fsn_ti cAMP relay https://github.com/geneontology/go-ontology/issues/21369 pg 2021-06-29T14:14:39Z biological_process owl:Class
GO:0098789 biolink:NamedThing pre-mRNA cleavage required for polyadenylation The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation. got7fsn_ti cleavage and polyadenylylation specificity factor activity|pre-mRNA cleavage factor activity biological_process owl:Class
GO:0002644 biolink:NamedThing negative regulation of tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction. got7fsn_ti down-regulation of tolerance induction|downregulation of tolerance induction|inhibition of tolerance induction|down regulation of tolerance induction biological_process owl:Class
GO:1903317 biolink:NamedThing regulation of protein maturation Any process that modulates the frequency, rate or extent of protein maturation. got7fsn_ti vw 2014-08-18T12:59:07Z biological_process owl:Class
GO:1901893 biolink:NamedThing positive regulation of cell septum assembly Any process that activates or increases the frequency, rate or extent of cell septum assembly. got7fsn_ti up-regulation of cell septum assembly|up regulation of cell septum assembly|upregulation of cell septum assembly|activation of cell septum assembly tb 2013-02-06T20:14:50Z biological_process owl:Class
GO:0004839 biolink:NamedThing ubiquitin activating enzyme activity Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. got7fsn_ti E1 ubiquitin-activating enzyme The ubiquitin activating enzyme catalyzes a ligation reaction. Reactome:R-HSA-8852134|Reactome:R-HSA-8852132|Reactome:R-HSA-8852133|Reactome:R-HSA-8865050|Reactome:R-HSA-8865090|EC:6.2.1.45|Reactome:R-HSA-8865098 molecular_function owl:Class
GO:1990700 biolink:NamedThing nucleolar chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin. got7fsn_ti nucleolar chromatin organisation|establishment or maintenance of nucleolar chromatin architecture mah 2015-03-16T12:11:01Z biological_process owl:Class
GO:0050771 biolink:NamedThing negative regulation of axonogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis. got7fsn_ti down regulation of axonogenesis|inhibition of axonogenesis|down-regulation of axonogenesis|downregulation of axonogenesis biological_process owl:Class
GO:0020004 biolink:NamedThing symbiont-containing vacuolar space The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane. got7fsn_ti symbiont-containing vacuole space|parasitophorous vacuolar space cellular_component owl:Class
GO:0070030 biolink:NamedThing alphav-beta1 integrin-osteopontin complex A protein complex that consists of an alphav-beta1 integrin complex bound to osteopontin. got7fsn_ti ITGAV-ITGB1-SPP1 complex cellular_component owl:Class
GO:0003171 biolink:NamedThing atrioventricular valve development The progression of the atrioventricular valve over time, from its formation to the mature structure. got7fsn_ti AV valve development dph 2009-10-08T11:14:21Z biological_process owl:Class
GO:0031666 biolink:NamedThing positive regulation of lipopolysaccharide-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. got7fsn_ti up regulation of lipopolysaccharide-mediated signaling pathway|positive regulation of LPS-mediated signaling pathway|activation of lipopolysaccharide-mediated signaling pathway|stimulation of lipopolysaccharide-mediated signaling pathway|up-regulation of lipopolysaccharide-mediated signaling pathway|positive regulation of lipopolysaccharide-mediated signalling pathway|upregulation of lipopolysaccharide-mediated signaling pathway biological_process owl:Class
GO:0000384 biolink:NamedThing first spliceosomal transesterification activity Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon. got7fsn_ti lariat formation, 5'-splice site cleavage molecular_function owl:Class
GO:0022889 biolink:NamedThing serine transmembrane transporter activity Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid. got7fsn_ti molecular_function owl:Class
GO:0032329 biolink:NamedThing serine transport The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti serine import tb 2012-10-01T11:10:51Z GO:0090478 biological_process owl:Class
GO:0003380 biolink:NamedThing establishment or maintenance of cytoskeleton polarity involved in gastrulation Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation. got7fsn_ti dph 2009-12-09T07:10:57Z biological_process owl:Class
GO:0003379 biolink:NamedThing establishment of cell polarity involved in gastrulation cell migration The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation. got7fsn_ti dph 2009-12-09T06:54:44Z biological_process owl:Class
GO:0010421 biolink:NamedThing hydrogen peroxide-mediated programmed cell death Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes. got7fsn_ti programmed cell death in response to hydrogen peroxide biological_process owl:Class
GO:0035073 biolink:NamedThing pupariation The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis. got7fsn_ti puparium biosynthesis|puparium formation biological_process owl:Class
GO:0035210 biolink:NamedThing prepupal development The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation. got7fsn_ti See also the fly_anatomy.ontology term 'prepupa ; FBbt:00002952'. biological_process owl:Class
GO:0006392 biolink:NamedThing transcription elongation from mitochondrial promoter The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase. got7fsn_ti RNA elongation from mitochondrial promoter biological_process owl:Class
GO:0046873 biolink:NamedThing metal ion transmembrane transporter activity Enables the transfer of metal ions from one side of a membrane to the other. got7fsn_ti heavy metal-exporting ATPase activity|high affinity metal ion uptake transporter activity|heavy metal ion porter activity|heavy metal ion:hydrogen symporter activity|heavy metal ion transporter activity|low affinity metal ion uptake transporter activity molecular_function owl:Class
GO:0030001 biolink:NamedThing metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti divalent metal ion transport|heavy metal ion transport GO:0070838 biological_process owl:Class
GO:0051663 biolink:NamedThing oocyte nucleus localization involved in oocyte dorsal/ventral axis specification The directed movement of the nucleus to a specific location within a cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. got7fsn_ti oocyte axis determination, oocyte nucleus localization|oocyte nucleus localization involved in oocyte dorsal/ventral axis determination|establishment and maintenance of oocyte nucleus localization during oocyte axis determination|oocyte nucleus localization involved in oocyte dorsal-ventral axis specification|oocyte nucleus localization during oocyte axis determination|oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification|oocyte nucleus localization involved in oocyte dorsoventral axis specification GO:0051662 biological_process owl:Class
GO:1901020 biolink:NamedThing negative regulation of calcium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity. got7fsn_ti inhibition of calcium ion transmembrane transporter activity|down-regulation of calcium ion transmembrane transporter activity|downregulation of calcium ion transmembrane transporter activity|down regulation of calcium ion transmembrane transporter activity rl 2012-06-15T07:54:32Z biological_process owl:Class
GO:0070588 biolink:NamedThing calcium ion transmembrane transport A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti calcium ion membrane transport|transmembrane calcium transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2009-04-28T10:44:09Z biological_process owl:Class
GO:0000348 biolink:NamedThing mRNA branch site recognition Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome. got7fsn_ti spliceosomal B complex biosynthesis|spliceosomal B complex formation|U2-type nuclear mRNA branch site recognition|nuclear mRNA branch site recognition|spliceosomal A complex formation|U12-type nuclear mRNA branch site recognition|spliceosomal A complex biosynthesis Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian). GO:0000370|GO:0000371 biological_process owl:Class
GO:0033615 biolink:NamedThing mitochondrial proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane. got7fsn_ti biological_process owl:Class
GO:0046572 biolink:NamedThing versicolorin B synthase activity Catalysis of the reaction: versiconal = versicolorin B + H2O. got7fsn_ti EC:4.2.1.143|RHEA:33859|MetaCyc:RXN-9494 molecular_function owl:Class
GO:1902176 biolink:NamedThing negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. got7fsn_ti negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|downregulation of intrinsic apoptotic signaling pathway in response to oxidative stress|down-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|inhibition of intrinsic apoptotic signaling pathway in response to oxidative stress|down regulation of intrinsic apoptotic signaling pathway in response to oxidative stress pr 2013-05-29T18:30:05Z biological_process owl:Class
GO:0006273 biolink:NamedThing lagging strand elongation The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. got7fsn_ti https://github.com/geneontology/go-ontology/issues/12633 biological_process owl:Class
GO:0043137 biolink:NamedThing DNA replication, removal of RNA primer Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease. got7fsn_ti Okazaki initiator RNA removal biological_process owl:Class
GO:0097712 biolink:NamedThing vesicle targeting, trans-Golgi to periciliary membrane compartment The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces. got7fsn_ti pr 2016-08-05T16:16:28Z biological_process owl:Class
GO:0072109 biolink:NamedThing glomerular mesangium development The process whose specific outcome is the progression of the glomerular mesangium over time, from its formation to the mature structure. The glomerular mesangium is the thin membrane connective tissue composed of mesangial cells, which helps to support the capillary loops in a renal glomerulus. got7fsn_ti mah 2010-02-22T10:35:24Z biological_process owl:Class
GO:0001850 biolink:NamedThing complement component C3a binding Binding to a C3a product of the complement cascade. got7fsn_ti molecular_function owl:Class
CL:0000623 biolink:NamedThing got7fsn_ti owl:Class
GO:0015591 biolink:NamedThing D-ribose transmembrane transporter activity Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. got7fsn_ti molecular_function owl:Class
GO:0015752 biolink:NamedThing D-ribose transmembrane transport The process in which D-ribose is transported across a lipid bilayer, from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. got7fsn_ti D-ribose transport biological_process owl:Class
GO:0060460 biolink:NamedThing left lung morphogenesis The process in which anatomical structures of the left lung are generated and organized. got7fsn_ti biological_process owl:Class
GO:0060459 biolink:NamedThing left lung development The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect. got7fsn_ti left pulmonary development biological_process owl:Class
GO:0098027 biolink:NamedThing virus tail, sheath The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm. got7fsn_ti bacteriophage tail sheath bm 2012-07-19T14:23:27Z cellular_component owl:Class
GO:1990107 biolink:NamedThing thiazole synthase activity Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O. got7fsn_ti 1-deoxy-D-xylulose 5-phosphate:thiol sulfurtransferase activity H2S can provide the sulfur in vitro. Part of the pathway for thiamine biosynthesis. pr 2013-05-28T12:36:04Z RHEA:26297 molecular_function owl:Class
CL:0000235 biolink:NamedThing got7fsn_ti owl:Class
GO:0046834 biolink:NamedThing lipid phosphorylation The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents. got7fsn_ti biological_process owl:Class
GO:0032921 biolink:NamedThing sarcosine oxidase complex A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity. got7fsn_ti cellular_component owl:Class
GO:0090042 biolink:NamedThing tubulin deacetylation The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti tb 2009-08-03T11:50:47Z biological_process owl:Class
GO:0060439 biolink:NamedThing trachea morphogenesis The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches. got7fsn_ti biological_process owl:Class
GO:0016323 biolink:NamedThing basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. got7fsn_ti cellular_component owl:Class
GO:0070197 biolink:NamedThing meiotic attachment of telomere to nuclear envelope The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation. got7fsn_ti attachment of telomeres to nuclear envelope|attachment of telomeric chromatin to nuclear envelope https://github.com/geneontology/go-ontology/issues/22043 biological_process owl:Class
GO:0007140 biolink:NamedThing male meiotic nuclear division A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline. got7fsn_ti male meiosis|male nuclear division biological_process owl:Class
GO:0003689 biolink:NamedThing DNA clamp loader activity Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis. got7fsn_ti PCNA loading activity|DNA-protein loading ATPase activity|DNA clamp loading ATPase activity|PCNA loading complex activity|protein-DNA loading ATPase activity GO:0033170 Reactome:R-HSA-174439|Reactome:R-HSA-176264 molecular_function owl:Class
GO:0061935 biolink:NamedThing fusion of sperm to egg plasma membrane involved in double fertilization forming two zygotes The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming two zygotes. got7fsn_ti dph 2017-09-05T18:38:08Z biological_process owl:Class
GO:0008526 biolink:NamedThing phosphatidylinositol transfer activity Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti intermembrane phosphotidylinositol transfer activity|phosphatidylinositol carrier activity|intermembrane phosphatidylinositol transfer activity|phosphatidylinositol transfer activity|phosphatidylinositol transporter activity krc 2017-03-17T04:22:47Z GO:0120018 Reactome:R-HSA-8874470|Reactome:R-HSA-8869241 molecular_function owl:Class
GO:0035091 biolink:NamedThing phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. got7fsn_ti phosphoinositide binding molecular_function owl:Class
GO:0071763 biolink:NamedThing nuclear membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. got7fsn_ti nuclear membrane organization and biogenesis|nuclear membrane organisation mah 2010-03-29T03:59:35Z biological_process owl:Class
GO:0022036 biolink:NamedThing rhombomere cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell. got7fsn_ti biological_process owl:Class
GO:0086063 biolink:NamedThing voltage-gated sodium channel activity involved in SA node cell action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated sodium channel activity involved in sinoatrial node cardiac muscle cell action potential|voltage-gated sodium channel activity involved in SA node cardiac muscle cell action potential|voltage-gated sodium channel activity involved in SAN cardiac muscle cell action potential|voltage-gated sodium channel activity involved in sinus node cardiac muscle cell action potential dph 2011-11-17T01:53:08Z molecular_function owl:Class
GO:0086046 biolink:NamedThing membrane depolarization during SA node cell action potential The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti membrane depolarization involved in regulation of sinoatrial node cardiac muscle cell action potential|membrane depolarization involved in regulation of sinus node cardiac muscle cell action potential|membrane depolarization involved in regulation of SA node cardiac muscle cell action potential|membrane depolarization involved in regulation of SAN cardiac muscle cell action potential dph 2011-11-16T10:52:57Z biological_process owl:Class
GO:0009782 biolink:NamedThing photosystem I antenna complex The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs). got7fsn_ti cellular_component owl:Class
GO:0001535 biolink:NamedThing radial spoke head Protein complex forming part of eukaryotic flagellar apparatus. got7fsn_ti radial spokehead cellular_component owl:Class
GO:0008637 biolink:NamedThing apoptotic mitochondrial changes The morphological and physiological alterations undergone by mitochondria during apoptosis. got7fsn_ti This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it. biological_process owl:Class
GO:0001768 biolink:NamedThing establishment of T cell polarity The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell. got7fsn_ti T-cell polarization|establishment of T-lymphocyte polarity|T cell polarization|T lymphocyte polarization|establishment of T-cell polarity|establishment of T lymphocyte polarity biological_process owl:Class
GO:0007343 biolink:NamedThing egg activation The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm. got7fsn_ti Wikipedia:Egg_activation biological_process owl:Class
GO:0005712 biolink:NamedThing chiasma A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over. got7fsn_ti Wikipedia:Chiasma_(genetics) cellular_component owl:Class
GO:0030553 biolink:NamedThing cGMP binding Binding to cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). got7fsn_ti 3',5'-cGMP binding|3',5' cGMP binding|cyclic GMP binding molecular_function owl:Class
GO:0071988 biolink:NamedThing protein localization to spindle pole body A process in which a protein is transported to, or maintained at, the spindle pole body. got7fsn_ti protein localisation to spindle pole body mah 2010-10-25T10:56:33Z biological_process owl:Class
GO:0043219 biolink:NamedThing lateral loop Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode. got7fsn_ti paranodal loop|Schwann cell paranodal termination|oligodendrocyte paranodal termination NIF_Subcellular:sao1067215520|NIF_Subcellular:sao1354781919 cellular_component owl:Class
GO:0070115 biolink:NamedThing organellar chromatophore intermembrane space The region between the inner and outer lipid bilayers that surround an organellar chromatophore. got7fsn_ti Paulinella-type chromatophore intermembrane space cellular_component owl:Class
GO:0000819 biolink:NamedThing sister chromatid segregation The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets. got7fsn_ti biological_process owl:Class
GO:0009575 biolink:NamedThing chromoplast stroma The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material. got7fsn_ti cellular_component owl:Class
NCBITaxon:Union_0000006 biolink:NamedThing got7fsn_ti owl:Class
GO:0060713 biolink:NamedThing labyrinthine layer morphogenesis The process in which the labyrinthine layer of the placenta is generated and organized. got7fsn_ti dph 2009-06-10T08:10:19Z biological_process owl:Class
GO:0006931 biolink:NamedThing substrate-dependent cell migration, cell attachment to substrate The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions. got7fsn_ti substrate-bound cell migration, cell attachment to substrate biological_process owl:Class
GO:0015548 biolink:NamedThing organomercurial transmembrane transporter activity Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom. got7fsn_ti carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity|organomercurial transporter activity molecular_function owl:Class
GO:0015897 biolink:NamedThing organomercurial transport The process in which an organomercurial compound is transported across a membrane. Organomercurial substances are any organic compound containing a mercury atom. got7fsn_ti biological_process owl:Class
GO:0005021 biolink:NamedThing vascular endothelial growth factor-activated receptor activity Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti vascular endothelial growth factor E-activated receptor activity|VEGFR activity|VEGF-C-activated receptor activity|VEGF-E-activated receptor activity|VEGF-A-activated receptor activity|VEGF receptor activity|VEGF-B-activated receptor activity|VEGF-activated receptor activity|VEGF-D-activated receptor activity|vascular endothelial growth factor receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand VEGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. GO:0036327|GO:0036329|GO:0036326|GO:0036330|GO:0036328 molecular_function owl:Class
GO:0045262 biolink:NamedThing plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species. got7fsn_ti proton-transporting ATP synthase complex, catalytic core F(1)|hydrogen-transporting ATP synthase, F1 sector See also the cellular component term 'plasma membrane ; GO:0005886'. cellular_component owl:Class
GO:0045260 biolink:NamedThing plasma membrane proton-transporting ATP synthase complex A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species. got7fsn_ti hydrogen-translocating F-type ATPase complex|proton-transporting ATP synthase complex|plasma membrane hydrogen-translocating F-type ATPase complex|hydrogen-transporting ATP synthase GO:0045256 cellular_component owl:Class
GO:0061691 biolink:NamedThing detoxification of hydrogen peroxide Any process that reduces or removes the toxicity of hydrogen peroxide. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration. got7fsn_ti dph 2015-05-05T12:42:18Z biological_process owl:Class
GO:0042542 biolink:NamedThing response to hydrogen peroxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. got7fsn_ti biological_process owl:Class
GO:0034584 biolink:NamedThing piRNA binding Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. got7fsn_ti Piwi-associated RNA binding molecular_function owl:Class
GO:0002179 biolink:NamedThing homodimeric serine palmitoyltransferase complex A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine. got7fsn_ti This complex occurs primarily in bacteria. hjd 2010-12-03T10:50:59Z cellular_component owl:Class
GO:0034590 biolink:NamedThing L-hydroxyproline transmembrane transporter activity Enables the transfer of L-hydroxyproline from one side of a membrane to the other. got7fsn_ti 4-hydroxyproline transmembrane transporter activity Reactome:R-HSA-6784213 molecular_function owl:Class
GO:0034589 biolink:NamedThing hydroxyproline transport The directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-hydroxyproline transport|4-hydroxyproline transport biological_process owl:Class
GO:0071134 biolink:NamedThing alpha9-beta1 integrin-thrombospondin-1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to thrombospondin-1. got7fsn_ti ITGA9-ITGB1-THBS1 complex mah 2009-11-13T02:29:07Z cellular_component owl:Class
GO:0072088 biolink:NamedThing nephron epithelium morphogenesis The process in which the anatomical structures of the nephron epithelium are generated and organized. The nephron epithelium is a tissue that covers the surface of a nephron. got7fsn_ti mah 2010-02-08T01:19:06Z biological_process owl:Class
GO:1900454 biolink:NamedThing positive regulation of long-term synaptic depression Any process that activates or increases the frequency, rate or extent of long term synaptic depression. got7fsn_ti positive regulation of long term synaptic depression|upregulation of LTD|up regulation of long term depression|positive regulation of long term depression|positive regulation of LTD|activation of long term synaptic depression|upregulation of long term depression|up regulation of LTD|activation of LTD|activation of long term depression|upregulation of long term synaptic depression|up-regulation of long term synaptic depression|up-regulation of long term depression|up regulation of long term synaptic depression|up-regulation of LTD rl 2012-04-27T03:55:23Z biological_process owl:Class
GO:0043996 biolink:NamedThing histone acetyltransferase activity (H4-K8 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8). got7fsn_ti histone lysine N-acetyltransferase activity (H4-K8 specific) molecular_function owl:Class
GO:0052807 biolink:NamedThing aflatoxin reductase (coenzyme F420) activity Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. got7fsn_ti aflatoxin:coenzyme F420 oxidoreductase activity|coenzyme F420-dependent aflatoxin reductase activity|aflatoxin:reduced coenzyme F420 reductase activity|coenzyme F420-aflatoxin reductase activity ai 2011-09-22T04:08:13Z molecular_function owl:Class
GO:0046223 biolink:NamedThing aflatoxin catabolic process The chemical reactions and pathways resulting in the breakdown of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. got7fsn_ti aflatoxin breakdown|aflatoxin catabolism|aflatoxin degradation biological_process owl:Class
GO:0007056 biolink:NamedThing spindle assembly involved in female meiosis The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster. got7fsn_ti female meiotic spindle assembly biological_process owl:Class
GO:0042060 biolink:NamedThing wound healing The series of events that restore integrity to a damaged tissue, following an injury. got7fsn_ti Wikipedia:Wound_healing biological_process owl:Class
GO:0048898 biolink:NamedThing anterior lateral line system development The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. got7fsn_ti ALL system development biological_process owl:Class
GO:0032276 biolink:NamedThing regulation of gonadotropin secretion Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin. got7fsn_ti regulation of gonadotrophin secretion biological_process owl:Class
GO:0000222 biolink:NamedThing plasma membrane proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane. got7fsn_ti plasma membrane hydrogen ion-transporting ATPase V0 domain cellular_component owl:Class
CHEBI:59789 biolink:NamedThing got7fsn_ti owl:Class
GO:0021582 biolink:NamedThing medulla oblongata maturation A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. got7fsn_ti myelencephalon maturation|medulla maturation biological_process owl:Class
GO:1904600 biolink:NamedThing actin fusion focus assembly The aggregation, arrangement and bonding together of a set of components to form an actin fusion focus. got7fsn_ti actin fusion focus formation https://github.com/geneontology/go-ontology/issues/21688 al 2015-08-26T10:34:48Z biological_process owl:Class
GO:0000747 biolink:NamedThing conjugation with cellular fusion A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti cell fusion|mating GO:0007333|GO:0007322|GO:0030461|GO:0030477 biological_process owl:Class
GO:0020039 biolink:NamedThing pellicle The structure enclosing certain parasite cells such as certain apicomplexa and Euglenozoa; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles. got7fsn_ti cellular_component owl:Class
GO:0021966 biolink:NamedThing corticospinal neuron axon guidance The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues. got7fsn_ti corticospinal neuron axon pathfinding biological_process owl:Class
GO:0007605 biolink:NamedThing sensory perception of sound The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound. got7fsn_ti perception of sound|hearing Wikipedia:Hearing_(sense) biological_process owl:Class
GO:0062009 biolink:NamedThing secondary palate development The biological process whose specific outcome is the progression of the secondary palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The secondary palate is the part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences. got7fsn_ti dph 2018-02-26T22:55:20Z biological_process owl:Class
GO:0009704 biolink:NamedThing de-etiolation The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll. got7fsn_ti biological_process owl:Class
GO:0052707 biolink:NamedThing N-alpha,N-alpha,N-alpha-trimethyl-L-histidine biosynthesis from histidine The pathway resulting in the formation of N-alpha,N-alpha,N-alpha-trimethyl-L-histidine from histidine. Histidine undergoes three methylations by a histidine-alpha-N-methyltransferase (EC:2.1.1.44) to form N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (also known as hercynine or histidine betaine). got7fsn_ti histidine catabolism to N-alpha,N-alpha,N-alpha-trimethyl-L-histidine|histidine betaine biosynthesis from histidine|hercynine biosynthesis from histidine|histidine catabolism to hercynine|histidine catabolic process to hercynine ai 2011-08-05T02:07:24Z KEGG_REACTION:R01169 biological_process owl:Class
GO:0052705 biolink:NamedThing methylhistidine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha-methyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha-dimethyl-L-histidine. got7fsn_ti S-adenosyl-L-methionine:alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity|histidine-alpha-N-methyltransferase activity|S-adenosyl-L-methionine:N-alpha-dimethyl-L-histidine N-alpha-methyltransferase activity|methylhistidine methyltransferase activity ai 2011-08-05T11:54:54Z molecular_function owl:Class
GO:0150069 biolink:NamedThing negative regulation of tubulin deacetylase activity Any process that stops, prevents or reduces the frequency, rate or extent of tubulin deacetylase activity. got7fsn_ti bc 2018-07-24T10:40:19Z biological_process owl:Class
GO:0005747 biolink:NamedThing mitochondrial respiratory chain complex I A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. got7fsn_ti GO:0005748 cellular_component owl:Class
GO:0030526 biolink:NamedThing granulocyte macrophage colony-stimulating factor receptor complex The heterodimeric receptor for granulocyte macrophage colony-stimulating factor. got7fsn_ti GM-CSF receptor complex|granulocyte macrophage colony stimulating factor receptor complex cellular_component owl:Class
GO:0043404 biolink:NamedThing corticotropin-releasing hormone receptor activity Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity. got7fsn_ti corticotropin-releasing factor receptor activity|CRH receptor activity|adrenocorticotropin-releasing hormone receptor activity|CRF receptor activity GO:0031636 molecular_function owl:Class
GO:0051424 biolink:NamedThing corticotropin-releasing hormone binding Binding to corticotropin-releasing hormone, a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. got7fsn_ti corticotropin-releasing factor binding|CRF binding|corticoliberin binding|CRH binding GO:0017047 molecular_function owl:Class
GO:0045494 biolink:NamedThing photoreceptor cell maintenance Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light. got7fsn_ti biological_process owl:Class
GO:0042876 biolink:NamedThing aldarate transmembrane transporter activity Enables the transfer of aldarate from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042869 biolink:NamedThing aldarate transmembrane transport The process in which aldarate is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti aldarate transport biological_process owl:Class
GO:0098643 biolink:NamedThing banded collagen fibril A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands). got7fsn_ti cellular_component owl:Class
PATO:0002309 biolink:NamedThing got7fsn_ti owl:Class
GO:0010095 biolink:NamedThing specification of petal identity The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0007129 biolink:NamedThing homologous chromosome pairing at meiosis The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Homologous chromosome pairing begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete. got7fsn_ti homologous chromosome pairing at meiosis|chromosomal synapsis|synapsis|chromosomal pairing Wikipedia:Synapsis biological_process owl:Class
GO:0048337 biolink:NamedThing positive regulation of mesodermal cell fate specification Any process that activates or increases the frequency, rate or extent of mesoderm cell fate specification. got7fsn_ti up regulation of mesodermal cell fate specification|upregulation of mesodermal cell fate specification|stimulation of mesodermal cell fate specification|activation of mesodermal cell fate specification|up-regulation of mesodermal cell fate specification biological_process owl:Class
GO:0047270 biolink:NamedThing lipopolysaccharide glucosyltransferase II activity Catalysis of the reaction: lipopolysaccharide + UDP-D-glucose = D-glucosyl-lipopolysaccharide + UDP. got7fsn_ti UDP-glucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity|UDPglucose:galactosyl-lipopolysaccharide alpha-D-glucosyltransferase activity|LPS glucosyltransferase II activity|uridine diphosphoglucose-galactosylpolysaccharide glucosyltransferase activity EC:2.4.1.73|MetaCyc:2.4.1.73-RXN molecular_function owl:Class
GO:0032587 biolink:NamedThing ruffle membrane The portion of the plasma membrane surrounding a ruffle. got7fsn_ti membrane ruffle cellular_component owl:Class
GO:0001726 biolink:NamedThing ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. got7fsn_ti membrane ruffle cellular_component owl:Class
GO:0005971 biolink:NamedThing ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. got7fsn_ti RNR complex|ribonucleotide reductase complex cellular_component owl:Class
GO:0140399 biolink:NamedThing aflatoxin B synthase activity Catalyzes the reaction: 8-O-methylsterigmatocystin + 2 [reduced NADPH--hemoprotein reductase] + 2 O(2) <=> aflatoxin B + 2 [oxidized NADPH--hemoprotein reductase] + H(2)O + methanol + CO(2). Produces both aflatoxin B(1) and aflatoxin B(2). got7fsn_ti pg 2019-11-29T11:06:07Z RHEA:35759|EC:1.14.14.117|MetaCyc:RXN-9497|MetaCyc:RXN-9502 molecular_function owl:Class
GO:0007598 biolink:NamedThing blood coagulation, extrinsic pathway A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X. got7fsn_ti See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. biological_process owl:Class
GO:0072378 biolink:NamedThing blood coagulation, fibrin clot formation A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events. got7fsn_ti See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. mah 2010-11-22T03:09:32Z biological_process owl:Class
GO:0016230 biolink:NamedThing sphingomyelin phosphodiesterase activator activity Increases the activity of the enzyme sphingomyelin phosphodiesterase. got7fsn_ti neutral sphingomyelinase activator molecular_function owl:Class
GO:0072579 biolink:NamedThing glycine receptor clustering The receptor clustering process in which glycine receptors are localized to distinct domains in the cell membrane. got7fsn_ti mah 2011-02-03T01:47:40Z biological_process owl:Class
GO:0044480 biolink:NamedThing envenomation resulting in positive regulation of mast cell degranulation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism. got7fsn_ti jl 2012-01-19T02:54:37Z biological_process owl:Class
GO:0071697 biolink:NamedThing ectodermal placode morphogenesis The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. got7fsn_ti mah 2010-03-02T11:49:51Z biological_process owl:Class
GO:0071587 biolink:NamedThing CAAX-box protein modification The covalent alteration of one or more amino acid residues within the CAAX box region of CAAX box proteins. got7fsn_ti mah 2010-01-28T04:48:56Z biological_process owl:Class
GO:0080120 biolink:NamedThing CAAX-box protein maturation A series of specific posttranslational modifications to the CAAX box region of CAAX box proteins. CAAX box proteins are eukaryotic proteins that contain a CAAX motif where the C is a cysteine, the two A residues are aliphatic amino acids and the X can be one of several amino acids. The CAAX-box proteins undergo three sequential, enzymatic, post-translational modifications essential to their targeting: First, the proteins are prenylated by one of two prenyltransferases called farnesyltransferase and geranylgeranyltransferase-I. Prenylation results in the covalent attachment of either farnesyl or geranylgeranyl isoprenoid groups to the cysteine in the CAAX box motif. Prenylation is followed by proteolytic removal of the last three amino acids of the protein (AAX). Finally, the newly exposed carboxylate group of the isoprenylcysteine is methylated by an ER-associated prenyl-dependent carboxylmethyltransferase. got7fsn_ti CAAX-box protein processing|farnesylated protein maturation dhl 2009-04-28T03:06:13Z biological_process owl:Class
GO:0021943 biolink:NamedThing formation of radial glial scaffolds The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells. got7fsn_ti Bergmann fiber biosynthesis|Bergmann fiber formation biological_process owl:Class
CL:0000681 biolink:NamedThing got7fsn_ti owl:Class
GO:0033374 biolink:NamedThing protein localization to T cell secretory granule A process in which a protein is transported to, or maintained in, a location within a secretory granule in a T cell. got7fsn_ti protein localization in T lymphocyte secretory granule|protein localisation in T cell secretory granule|protein localization in T-cell secretory granule|protein localization in T-lymphocyte secretory granule|protein localization in T cell secretory granule biological_process owl:Class
GO:0060976 biolink:NamedThing coronary vasculature development The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure. got7fsn_ti heart blood vessel development|cardiac blood vessel development|heart vasculature development|coronary blood vessel development|cardiac vasculature development dph 2009-10-06T12:15:23Z biological_process owl:Class
GO:0070864 biolink:NamedThing sperm individualization complex A macromolecular complex that includes cytoskeletal components and part of the cell membrane. Forms at the nuclear end of a male germline syncytium, or cyst, and translocates the over the length of the syncytium in the course of sperm individualization. Each complex contains an array of 64 investment cones, one per nucleus, that move synchronously along the spermatogenic cyst. got7fsn_ti mah 2009-08-19T01:25:33Z cellular_component owl:Class
GO:1990413 biolink:NamedThing eyespot apparatus A small pigmented organelle used in single-celled organisms to detect light. got7fsn_ti stigma|eyespot cjm 2014-07-03T21:26:24Z cellular_component owl:Class
GO:0015483 biolink:NamedThing long-chain fatty acid transporting porin activity Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. got7fsn_ti TC:1.B.9.1.1 molecular_function owl:Class
GO:0015909 biolink:NamedThing long-chain fatty acid transport The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. got7fsn_ti biological_process owl:Class
GO:1903741 biolink:NamedThing negative regulation of phosphatidate phosphatase activity Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidate phosphatase activity. got7fsn_ti down regulation of phosphatic acid phosphohydrolase activity|down regulation of acid phosphatidyl phosphatase activity|down-regulation of acid phosphatidyl phosphatase activity|down-regulation of phosphatidate phosphohydrolase activity|down regulation of phosphatidate phosphohydrolase activity|down-regulation of phosphatidate phosphatase activity|down-regulation of 3-sn-phosphatidate phosphohydrolase activity|down regulation of 3-sn-phosphatidate phosphohydrolase activity|negative regulation of acid phosphatidyl phosphatase activity|downregulation of acid phosphatidyl phosphatase activity|down regulation of phosphatic acid phosphatase activity|downregulation of 3-sn-phosphatidate phosphohydrolase activity|inhibition of phosphatidic acid phosphatase activity|negative regulation of phosphatic acid phosphatase activity|inhibition of 3-sn-phosphatidate phosphohydrolase activity|inhibition of phosphatic acid phosphatase activity|negative regulation of 3-sn-phosphatidate phosphohydrolase activity|negative regulation of phosphatidic acid phosphatase activity|down-regulation of phosphatic acid phosphohydrolase activity|downregulation of phosphatic acid phosphatase activity|inhibition of phosphatidate phosphohydrolase activity|downregulation of phosphatidate phosphatase activity|down-regulation of phosphatidic acid phosphatase activity|down regulation of phosphatidate phosphatase activity|inhibition of acid phosphatidyl phosphatase activity|negative regulation of phosphatidate phosphohydrolase activity|down regulation of phosphatidic acid phosphatase activity|inhibition of phosphatic acid phosphohydrolase activity|negative regulation of phosphatic acid phosphohydrolase activity|down-regulation of phosphatic acid phosphatase activity|downregulation of phosphatidate phosphohydrolase activity|downregulation of phosphatidic acid phosphatase activity|inhibition of phosphatidate phosphatase activity|downregulation of phosphatic acid phosphohydrolase activity tb 2014-12-11T23:37:54Z biological_process owl:Class
GO:0071072 biolink:NamedThing negative regulation of phospholipid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. got7fsn_ti negative regulation of phospholipid biosynthesis|negative regulation of phospholipid formation|negative regulation of phospholipid synthesis|down regulation of phospholipid biosynthetic process|negative regulation of phospholipid anabolism|down-regulation of phospholipid biosynthetic process|downregulation of phospholipid biosynthetic process|inhibition of phospholipid biosynthetic process mah 2009-11-04T03:14:08Z biological_process owl:Class
GO:2001205 biolink:NamedThing negative regulation of osteoclast development Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development. got7fsn_ti negative regulation of osteoclast cell development yaf 2011-11-10T10:59:06Z biological_process owl:Class
GO:0021744 biolink:NamedThing dorsal motor nucleus of vagus nerve development The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0048273 biolink:NamedThing mitogen-activated protein kinase p38 binding Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. got7fsn_ti MAPK p38 binding molecular_function owl:Class
GO:1905349 biolink:NamedThing ciliary transition zone assembly The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone. got7fsn_ti cilium transition zone formation|cilial transition zone formation|cilial transition zone assembly|ciliary transition zone formation|cilium transition zone assembly pr 2016-08-04T14:49:43Z biological_process owl:Class
GO:0006794 biolink:NamedThing phosphorus utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism. got7fsn_ti biological_process owl:Class
GO:0006793 biolink:NamedThing phosphorus metabolic process The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4). got7fsn_ti phosphorus metabolism biological_process owl:Class
GO:0044734 biolink:NamedThing envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. got7fsn_ti envenomation resulting in positive regulation of ASIC channel activity in other organism jl 2012-11-06T16:02:01Z biological_process owl:Class
GO:0044739 biolink:NamedThing positive regulation of acid-sensing ion channel in other organism Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism. got7fsn_ti positive regulation of ASIC channel in other organism jl 2012-11-06T16:56:27Z biological_process owl:Class
GO:0071439 biolink:NamedThing clathrin complex A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. got7fsn_ti clathrin triskelion mah 2009-12-16T03:17:58Z cellular_component owl:Class
GO:1901400 biolink:NamedThing positive regulation of transforming growth factor beta3 activation Any process that activates or increases the frequency, rate or extent of transforming growth factor beta3 activation. got7fsn_ti positive regulation of TGF-beta 3 activation|up regulation of transforming growth factor beta3 activation|positive regulation of TGFB3 activation|activation of TGF-beta 3 activation|up regulation of TGFB3 activation|up-regulation of TGFbeta 3 activation|upregulation of TGFbeta 3 activation|upregulation of transforming growth factor beta3 activation|up-regulation of transforming growth factor beta3 activation|activation of TGFbeta 3 activation|up regulation of TGF-beta 3 activation|up-regulation of TGF-beta 3 activation|positive regulation of TGFbeta 3 activation|up-regulation of TGFB3 activation|up regulation of TGFbeta 3 activation|upregulation of TGF-beta 3 activation|activation of TGFB3 activation|upregulation of TGFB3 activation|activation of transforming growth factor beta3 activation bf 2012-10-01T10:50:49Z biological_process owl:Class
GO:0032907 biolink:NamedThing transforming growth factor beta3 production The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti TGF-B3 production|TGFB3 production|transforming growth factor-beta3 production biological_process owl:Class
GO:0072127 biolink:NamedThing renal capsule development The process whose specific outcome is the progression of the renal capsule over time, from its formation to the mature structure. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. got7fsn_ti mah 2010-02-22T02:02:55Z biological_process owl:Class
GO:1905392 biolink:NamedThing plant organ morphogenesis The developmental process by which a plant organ is generated and organized. got7fsn_ti tb 2016-08-24T00:21:19Z biological_process owl:Class
GO:0022625 biolink:NamedThing cytosolic large ribosomal subunit The large subunit of a ribosome located in the cytosol. got7fsn_ti eukaryotic ribosomal LSU|50S ribosomal subunit|60S ribosomal subunit|prokaryotic large ribosomal subunit GO:0005842|GO:0030872|GO:0009282|GO:0030498 cellular_component owl:Class
GO:0022626 biolink:NamedThing cytosolic ribosome A ribosome located in the cytosol. got7fsn_ti 80S ribosome|70S ribosome GO:0009281|GO:0005830|GO:0030871 cellular_component owl:Class
GO:0000464 biolink:NamedThing endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs. got7fsn_ti endonucleolytic cleavage at A3 biological_process owl:Class
GO:0061098 biolink:NamedThing positive regulation of protein tyrosine kinase activity Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity. got7fsn_ti dph 2010-04-26T02:34:53Z biological_process owl:Class
GO:0005663 biolink:NamedThing DNA replication factor C complex A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides. got7fsn_ti activator 1 complex|RFC complex cellular_component owl:Class
GO:0005657 biolink:NamedThing replication fork The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. got7fsn_ti replication focus Wikipedia:Replication_fork cellular_component owl:Class
GO:0034348 biolink:NamedThing type III interferon receptor activity Combining with a type III interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Interferon lambda is the only member of the type III interferon found so far. got7fsn_ti interferon-lambda receptor activity Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. molecular_function owl:Class
GO:0005814 biolink:NamedThing centriole A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle. got7fsn_ti daughter centriole|mother centriole In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. NIF_Subcellular:sao95019936|Wikipedia:Centriole cellular_component owl:Class
GO:0099608 biolink:NamedThing regulation of action potential firing pattern Any process that regulates the temporal pattern of a sequence of action potentials in a neuron. got7fsn_ti spike train sculpting biological_process owl:Class
GO:1904442 biolink:NamedThing negative regulation of thyroid gland epithelial cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of thyroid gland epithelial cell proliferation. got7fsn_ti down regulation of Hurthle cell proliferation|inhibition of Hurthle cell proliferation|downregulation of thyroid follicular cell proliferation|down regulation of thyroid follicular cell proliferation|down-regulation of Hurthle cell proliferation|negative regulation of thyroid follicular cell proliferation|inhibition of thyroid follicular cell proliferation|negative regulation of Hurthle cell proliferation|inhibition of thyroid gland epithelial cell proliferation|down regulation of thyroid gland epithelial cell proliferation|down-regulation of thyroid gland epithelial cell proliferation|downregulation of thyroid gland epithelial cell proliferation|downregulation of Hurthle cell proliferation|down-regulation of thyroid follicular cell proliferation sl 2015-07-06T15:41:15Z biological_process owl:Class
NCBITaxon:32525 biolink:NamedThing got7fsn_ti owl:Class
GO:0097754 biolink:NamedThing clathrin-mediated membrane bending A membrane bending process mediated by clathrin. got7fsn_ti pr 2017-01-25T16:38:42Z biological_process owl:Class
GO:0015124 biolink:NamedThing allantoate transmembrane transporter activity Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen. got7fsn_ti molecular_function owl:Class
GO:0015719 biolink:NamedThing allantoate transport The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti allantoin/allantoate transport biological_process owl:Class
GO:0046814 biolink:NamedThing coreceptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a co-receptor on the host cell surface. got7fsn_ti virion attachment, binding of host cell surface coreceptor biological_process owl:Class
GO:0039706 biolink:NamedThing co-receptor binding Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell. got7fsn_ti bf 2013-11-25T14:41:42Z molecular_function owl:Class
GO:0048619 biolink:NamedThing embryonic hindgut morphogenesis The process in which the anatomical structures of the hindgut are generated and organized, during the embryonic phase. got7fsn_ti biological_process owl:Class
GO:0043514 biolink:NamedThing interleukin-12 complex A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space. got7fsn_ti IL12A|IL12B|IL-12 complex|p35|p40 Note that this heterodimeric cytokine utilizes the IL-12p35 subunit as its alpha chain, which is also used by IL-35 as its alpha chain, and utilizes the IL-12p40 subunit as its beta chain, which is also used by IL-23 as its beta chain. cellular_component owl:Class
GO:0032437 biolink:NamedThing cuticular plate A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted. got7fsn_ti cellular_component owl:Class
CL:0000855 biolink:NamedThing got7fsn_ti owl:Class
GO:0140638 biolink:NamedThing small ribosomal subunit processing complex A small heterodimeric protein complex that is required during early maturation of nascent 40S ribosomal subunits. The complex has endonuclease activity, it interacts with the small ribosomal subunit pre-rRNA and cleave it it to produce the mature 18S (or small ribosomal subunit) rRNA. In S. cerevisiae it is composed of Rcl1p and Bms1p. got7fsn_ti small ribosomal subunit maturation complex https://github.com/geneontology/go-ontology/issues/15290 pg 2021-04-21T08:07:11Z cellular_component owl:Class
GO:0042274 biolink:NamedThing ribosomal small subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis. got7fsn_ti ribosomal small subunit biogenesis and assembly biological_process owl:Class
GO:0015603 biolink:NamedThing iron chelate transmembrane transporter activity Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions. got7fsn_ti molecular_function owl:Class
GO:0033214 biolink:NamedThing siderophore-dependent iron import into cell A process in which iron (Fe3+) is solubilized by ferric iron-specific chelators, known as siderophores, excreted by a cell; the iron-siderophore complex is then transported into the cell by specific cell surface receptors. got7fsn_ti iron chelate transport|iron assimilation by capture and transport|iron assimilation by chelation and transport GO:0015688|GO:0033213 biological_process owl:Class
GO:0060997 biolink:NamedThing dendritic spine morphogenesis The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. got7fsn_ti dph 2010-01-20T09:09:57Z biological_process owl:Class
GO:0060996 biolink:NamedThing dendritic spine development The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. got7fsn_ti dph 2010-01-20T09:06:33Z biological_process owl:Class
GO:0035511 biolink:NamedThing oxidative DNA demethylation Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. got7fsn_ti bf 2010-04-30T02:22:44Z biological_process owl:Class
GO:0008407 biolink:NamedThing chaeta morphogenesis The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell. got7fsn_ti bristle morphogenesis biological_process owl:Class
GO:0014802 biolink:NamedThing terminal cisterna The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release. got7fsn_ti Wikipedia:Terminal_cisterna cellular_component owl:Class
GO:0007356 biolink:NamedThing thorax and anterior abdomen determination Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product. got7fsn_ti biological_process owl:Class
GO:0007354 biolink:NamedThing zygotic determination of anterior/posterior axis, embryo The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade. got7fsn_ti biological_process owl:Class
GO:1990121 biolink:NamedThing H-NS complex A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA. got7fsn_ti histone-like protein H-NS complex|DNA-binding protein H-NS complex bhm 2013-06-12T10:08:31Z cellular_component owl:Class
GO:0015216 biolink:NamedThing purine nucleotide transmembrane transporter activity Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015865 biolink:NamedThing purine nucleotide transport The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. got7fsn_ti biological_process owl:Class
GO:0036449 biolink:NamedThing microtubule minus-end The end of a microtubule that does not preferentially grow (polymerize). got7fsn_ti microtubule minus end bf 2013-10-31T13:26:51Z cellular_component owl:Class
GO:1903105 biolink:NamedThing negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan Any process that stops, prevents or reduces the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan. got7fsn_ti negative regulation of insulin receptor signaling pathway of determination of adult lifespan|downregulation of daf-2 receptor signaling pathway of determination of adult lifespan|inhibition of insulin receptor signalling pathway of determination of adult lifespan|downregulation of insulin receptor signalling pathway of determination of adult lifespan|down regulation of daf-2 receptor signaling pathway of determination of adult lifespan|negative regulation of insulin receptor signalling pathway of determination of adult lifespan|down-regulation of insulin receptor signaling pathway of determination of adult lifespan|down regulation of insulin receptor signaling pathway of determination of adult lifespan|down regulation of insulin receptor signalling pathway of determination of adult lifespan|inhibition of daf-2 receptor signaling pathway of determination of adult lifespan|negative regulation of daf-2 receptor signaling pathway of determination of adult lifespan|downregulation of insulin receptor signaling pathway involved in determination of adult lifespan|downregulation of insulin receptor signaling pathway of determination of adult lifespan|down-regulation of insulin receptor signaling pathway involved in determination of adult lifespan|inhibition of insulin receptor signaling pathway of determination of adult lifespan|down regulation of insulin receptor signaling pathway involved in determination of adult lifespan|down-regulation of daf-2 receptor signaling pathway of determination of adult lifespan|down-regulation of insulin receptor signalling pathway of determination of adult lifespan|inhibition of insulin receptor signaling pathway involved in determination of adult lifespan kmv 2014-06-05T20:56:12Z biological_process owl:Class
GO:0035763 biolink:NamedThing dorsal motor nucleus of vagus nerve structural organization The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti dorsal motor nucleus of vagus nerve structural organisation bf 2011-03-29T02:47:56Z biological_process owl:Class
GO:0035762 biolink:NamedThing dorsal motor nucleus of vagus nerve morphogenesis The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form. got7fsn_ti bf 2011-03-29T02:47:18Z biological_process owl:Class
GO:0010599 biolink:NamedThing production of lsiRNA involved in RNA interference Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions. got7fsn_ti RNA interference, production of lsiRNA biological_process owl:Class
GO:0016246 biolink:NamedThing RNA interference The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. got7fsn_ti RNAi|posttranscriptional gene silencing by siRNA Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'. Wikipedia:RNA_interference biological_process owl:Class
GO:0034456 biolink:NamedThing UTP-C complex A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Rrp7p, Utp22p, Ckb1p, Cka1p, Ckb2p and Cka2p. got7fsn_ti Rrp7p-containing subcomplex of 90S preribosome Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. cellular_component owl:Class
GO:0007066 biolink:NamedThing female meiosis sister chromatid cohesion The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female. got7fsn_ti biological_process owl:Class
GO:0061011 biolink:NamedThing hepatic duct development The progression of the hepatic duct over time, from its formation to the mature structure. The hepatic duct is the duct that leads from the liver to the common bile duct. got7fsn_ti dph 2010-01-22T09:44:39Z biological_process owl:Class
GO:0016543 biolink:NamedThing male courtship behavior, orientation prior to leg tapping and wing vibration The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster. got7fsn_ti male courtship behaviour, orientation|male courtship behavior, orientation|male courtship behaviour, orientation prior to leg tapping and wing vibration biological_process owl:Class
GO:0007133 biolink:NamedThing meiotic anaphase I The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0043220 biolink:NamedThing Schmidt-Lanterman incisure Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier. got7fsn_ti Schmidt-Lanterman cleft GO:0044287 NIF_Subcellular:sao254777664 cellular_component owl:Class
GO:0043218 biolink:NamedThing compact myelin The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs. got7fsn_ti oligodendrocyte compact myelin|Schwann cell compact myelin NIF_Subcellular:sao1123256993 cellular_component owl:Class
GO:0048742 biolink:NamedThing regulation of skeletal muscle fiber development Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. got7fsn_ti regulation of skeletal myofibre development|regulation of skeletal muscle fibre development|regulation of skeletal myofiber development biological_process owl:Class
NCBITaxon:38254 biolink:NamedThing got7fsn_ti owl:Class
GO:0090658 biolink:NamedThing cone matrix sheath A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments. got7fsn_ti tb 2015-07-15T13:35:32Z cellular_component owl:Class
GO:0071061 biolink:NamedThing alpha6-beta4 integrin-CD151 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the tetraspanin CD151. got7fsn_ti ITGA6-ITGB4-CD151 complex mah 2009-11-03T04:02:37Z cellular_component owl:Class
GO:0004651 biolink:NamedThing polynucleotide 5'-phosphatase activity Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. got7fsn_ti 5'-polynucleotidase activity|polynucleotide 5'-triphosphatase activity|polynucleotide 5'-phosphohydrolase activity RHEA:11008|EC:3.1.3.33|MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN|Reactome:R-HSA-77078 molecular_function owl:Class
GO:0098507 biolink:NamedThing polynucleotide 5' dephosphorylation The process of removing one or more phosphate groups from the 5' end of a polynucleotide. got7fsn_ti biological_process owl:Class
GO:0061256 biolink:NamedThing mesonephric glomerular visceral epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. got7fsn_ti dph 2010-08-30T02:03:38Z biological_process owl:Class
GO:0062151 biolink:NamedThing catalase complex A protein-containing complex that is capable of catalase activity. got7fsn_ti dph 2019-09-17T12:18:02Z cellular_component owl:Class
GO:0061692 biolink:NamedThing cellular detoxification of hydrogen peroxide Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration. got7fsn_ti dph 2015-05-05T12:46:20Z biological_process owl:Class
GO:0043584 biolink:NamedThing nose development The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). got7fsn_ti nasus development biological_process owl:Class
GO:0002622 biolink:NamedThing regulation of B cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation. got7fsn_ti regulation of B-cell antigen processing and presentation|regulation of B-lymphocyte antigen processing and presentation|regulation of B lymphocyte antigen processing and presentation biological_process owl:Class
GO:0003151 biolink:NamedThing outflow tract morphogenesis The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. got7fsn_ti tb 2009-09-22T07:59:24Z biological_process owl:Class
GO:0062128 biolink:NamedThing MutSgamma complex A heterodimer involved in the stabilization of DNA recombination intermediates, the promotion of crossover recombination, and the proper assembly of the synaptonemal complex in meiotic prophase nuclei. In yeast the complex consists of two subunits, Msh4 and Msh5. got7fsn_ti Msh4-Msh5 complex dph 2019-06-04T14:48:15Z cellular_component owl:Class
GO:0048371 biolink:NamedThing lateral mesodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a lateral mesoderm cell. got7fsn_ti lateral mesoderm cell differentiation|lateral plate mesoderm cell differentiation|lateral plate mesodermal cell differentiation biological_process owl:Class
GO:1900224 biolink:NamedThing positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Any process that activates or increases the frequency, rate or extent of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. got7fsn_ti upregulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|up-regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|positive regulation of nodal signalling pathway involved in determination of lateral mesoderm left/right asymmetry|upregulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|up regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|up regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|positive regulation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|activation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|up-regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|activation of nodal signaling pathway of determination of left/right asymmetry in lateral mesoderm|activation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|upregulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|positive regulation of nodal signaling of determination of left/right asymmetry in lateral mesoderm|up regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|up-regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry vk 2012-03-22T02:30:13Z biological_process owl:Class
GO:1990563 biolink:NamedThing extracellular exosome complex A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome. got7fsn_ti exosome complex|extracellular vesicular exosome complex An example of this is SCD1 in human (UniProt symbol P18827) in PMID:22660413 (inferred from physical interaction). bhm 2014-11-25T16:35:53Z cellular_component owl:Class
GO:0051087 biolink:NamedThing chaperone binding Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. got7fsn_ti co-chaperonin activity|chaperone protein binding|co-chaperone activity molecular_function owl:Class
GO:0099500 biolink:NamedThing vesicle fusion to plasma membrane Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space. got7fsn_ti biological_process owl:Class
GO:0106037 biolink:NamedThing apicomedial cortex The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell. got7fsn_ti medioapical cortex hjd 2017-07-12T16:59:52Z cellular_component owl:Class
GO:0045179 biolink:NamedThing apical cortex The region that lies just beneath the plasma membrane on the apical edge of a cell. got7fsn_ti cellular_component owl:Class
GO:0007199 biolink:NamedThing G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP). got7fsn_ti GPCR signaling pathway via cGMP second messenger|guanylate cyclase-activating G-protein coupled receptor signaling pathway|G-protein signalling, coupled to cGMP nucleotide second messenger|G protein signalling, coupled to cGMP nucleotide second messenger|G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger|G protein signaling, coupled to cGMP nucleotide second messenger|G-protein signaling, coupled to cGMP nucleotide second messenger|GPCR signaling pathway via activation of guanylate cyclase activity biological_process owl:Class
GO:0031284 biolink:NamedThing positive regulation of guanylate cyclase activity Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity. got7fsn_ti stimulation of guanylate cyclase activity|upregulation of guanylate cyclase activity|up-regulation of guanylate cyclase activity|activation of guanylate cyclase activity|up regulation of guanylate cyclase activity biological_process owl:Class
GO:0010440 biolink:NamedThing stomatal lineage progression The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex. got7fsn_ti biological_process owl:Class
GO:0030343 biolink:NamedThing vitamin D3 25-hydroxylase activity Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O. got7fsn_ti cholecalciferol 25-hydroxylase activity Reactome:R-HSA-5602147|MetaCyc:RXN-9829|Reactome:R-HSA-209845|RHEA:32903 molecular_function owl:Class
GO:0036378 biolink:NamedThing calcitriol biosynthetic process from calciol Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol. got7fsn_ti vitamin D3 activation|calcitriol biosynthesis from calciol|1alpha,25-dihydroxycholecalciferol biosynthesis|1alpha,25-dihydroxyvitamin D3 biosynthesis|1alpha,25(OH)2D3 biosynthesis bf 2013-05-15T11:46:08Z biological_process owl:Class
GO:0045691 biolink:NamedThing regulation of embryo sac central cell differentiation Any process that modulates the frequency, rate or extent of female gametophyte central cell differentiation. got7fsn_ti regulation of female gametophyte central cell differentiation biological_process owl:Class
GO:0009559 biolink:NamedThing embryo sac central cell differentiation The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell. got7fsn_ti female gametophyte central cell differentiation|embryo sac endosperm mother cell differentiation biological_process owl:Class
GO:0035318 biolink:NamedThing imaginal disc-derived wing hair outgrowth Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair. got7fsn_ti wing hair outgrowth|wing prehair outgrowth biological_process owl:Class
GO:0035317 biolink:NamedThing imaginal disc-derived wing hair organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster. got7fsn_ti imaginal disc-derived wing hair organization and biogenesis|wing hair organization and biogenesis|wing hair organisation|wing trichome organization and biogenesis See also the fly_anatomy.ontology term 'wing hair ; FBbt:00004340'. biological_process owl:Class
GO:0060914 biolink:NamedThing heart formation The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable. got7fsn_ti cardiogenesis dph 2009-09-17T09:02:13Z biological_process owl:Class
GO:0071094 biolink:NamedThing alpha6-beta4 integrin-CD9 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the cell surface protein CD9. got7fsn_ti ITGA6-ITGB4-CD9 complex mah 2009-11-06T04:47:44Z cellular_component owl:Class
GO:0071255 biolink:NamedThing Cvt vesicle assembly A vesicle organization process that takes place as part of the Cvt pathway, and results in the formation of a double membrane-bounded cytosolic structure that sequesters precursor aminopeptidase I (prAPI). got7fsn_ti Cvt vesicle formation|cytoplasm-to-vacuole targetin vesicle assembly|Cvt vesicle biosynthesis|cytoplasm to vacuole targeting vesicle assembly mah 2009-12-04T10:39:50Z biological_process owl:Class
GO:0032258 biolink:NamedThing cytoplasm to vacuole transport by the Cvt pathway A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast. got7fsn_ti protein localization by the Cvt pathway|cytoplasm to vacuole targeting|cytoplasm-to-vacuole targeting biological_process owl:Class
GO:0003025 biolink:NamedThing regulation of systemic arterial blood pressure by baroreceptor feedback The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control. got7fsn_ti baroreceptor regulation of systemic arterial blood pressure biological_process owl:Class
GO:0003342 biolink:NamedThing proepicardium development The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum. got7fsn_ti dph 2009-12-01T10:30:17Z biological_process owl:Class
GO:0003343 biolink:NamedThing septum transversum development The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme. got7fsn_ti dph 2009-12-01T10:40:17Z biological_process owl:Class
GO:0030690 biolink:NamedThing Noc1p-Noc2p complex A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis. got7fsn_ti Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. cellular_component owl:Class
GO:0030687 biolink:NamedThing preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. got7fsn_ti 66S preribosome Note that this complex is 66S in Saccharomyces. cellular_component owl:Class
GO:0045261 biolink:NamedThing proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. got7fsn_ti hydrogen-transporting ATP synthase, F1 sector cellular_component owl:Class
GO:0000796 biolink:NamedThing condensin complex A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis. got7fsn_ti condensin I complex|13S condensin complex|condensin core heterodimer|SMC complex|Smc2-Smc4 complex|nuclear condensin complex|8S condensin complex https://github.com/geneontology/go-ontology/issues/12832 GO:0061814|GO:0000797|GO:0008621|GO:0000799|GO:0005676|GO:0008620 cellular_component owl:Class
GO:0006352 biolink:NamedThing DNA-templated transcription, initiation Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. got7fsn_ti DNA-dependent RNA polymerase complex assembly at promoter|initiation of DNA-dependent transcription|DNA-dependent transcription, initiation|initiation of transcription, DNA-dependent|transcription initiation, DNA-dependent|transcription initiation factor activity Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. biological_process owl:Class
GO:0097189 biolink:NamedThing apoptotic body A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um. got7fsn_ti apoptotic bleb|apoptotic vesicle pr 2011-11-22T08:05:20Z cellular_component owl:Class
GO:1903773 biolink:NamedThing negative regulation of viral budding via host ESCRT complex Any process that stops, prevents or reduces the frequency, rate or extent of viral budding via host ESCRT complex. got7fsn_ti down regulation of viral budding through the ESCRT machinery|inhibition of viral budding via host ESCRT complex|down-regulation of viral budding via host ESCRT complex|downregulation of viral budding through the ESCRT machinery|inhibition of viral budding through the ESCRT machinery|down regulation of viral budding via host ESCRT complex|down-regulation of viral budding through the ESCRT machinery|downregulation of viral budding via host ESCRT complex|negative regulation of viral budding through the ESCRT machinery als 2015-01-06T16:20:53Z biological_process owl:Class
GO:0061809 biolink:NamedThing NAD+ nucleotidase, cyclic ADP-ribose generating Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity. got7fsn_ti dph 2016-11-11T13:14:13Z MetaCyc:NADNUCLEOSID-RXN|EC:3.2.2.6 molecular_function owl:Class
GO:0002808 biolink:NamedThing regulation of antibacterial peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis. got7fsn_ti biological_process owl:Class
GO:0051780 biolink:NamedThing behavioral response to nutrient Any process that results in a change in the behavior of an organism as a result of a nutrient stimulus. got7fsn_ti behavioural response to nutrient biological_process owl:Class
GO:0097495 biolink:NamedThing H-NS-Hha complex A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes. got7fsn_ti pr 2013-08-08T14:37:33Z cellular_component owl:Class
GO:0044023 biolink:NamedThing histone kinase activity (H4-S1 specific) Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4. got7fsn_ti histone-serine kinase activity (H4-S1 specific)|histone serine kinase activity (H4-S1 specific) molecular_function owl:Class
GO:0021842 biolink:NamedThing chemorepulsion involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex. got7fsn_ti negative chemotaxis involved in interneuron migration from the subpallium to the cortex biological_process owl:Class
GO:0021840 biolink:NamedThing directional guidance of interneurons involved in migration from the subpallium to the cortex The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex. got7fsn_ti biological_process owl:Class
GO:0048838 biolink:NamedThing release of seed from dormancy The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release. got7fsn_ti biological_process owl:Class
GO:0110025 biolink:NamedThing DNA strand resection involved in replication fork processing The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing. got7fsn_ti kmv 2017-07-05T14:43:36Z biological_process owl:Class
GO:0140617 biolink:NamedThing transvection An epigenetic regulation of transcription by physical interaction between a cis-acting element (enhancer, silencer) of one allele on one chromosome and the promoter of the corresponding allele on the homologous chromosome. Transvection can lead to either gene activation or repression. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21038 pg 2021-03-08T18:30:47Z biological_process owl:Class
NCBITaxon:7147 biolink:NamedThing got7fsn_ti owl:Class
GO:0000123 biolink:NamedThing histone acetyltransferase complex A protein complex that possesses histone acetyltransferase activity. got7fsn_ti histone acetylase complex Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. cellular_component owl:Class
GO:0022015 biolink:NamedThing radial glial cell division in pallium The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes. got7fsn_ti biological_process owl:Class
GO:0031429 biolink:NamedThing box H/ACA snoRNP complex A box H/ACA RNP complex that is located in the nucleolus. got7fsn_ti box H/ACA small nucleolar ribonucleoprotein complex|box H/ACA snoRNP pseudouridylase complex cellular_component owl:Class
GO:0019070 biolink:NamedThing viral genome maturation The processes involved in creating a mature, stable viral genome. Begins after genome replication with a newly synthesized nucleic acid and ends when the genome is ready to be packaged. Includes the addition of proteins to the newly synthesized genome, and DNA repair processes. got7fsn_ti biological_process owl:Class
GO:0019068 biolink:NamedThing virion assembly A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed. got7fsn_ti phage assembly|viral assembly|viral particle assembly|virus particle assembly|virus assembly|virion assembly and maintenance|virion organization|bacteriophage assembly GO:0042963 biological_process owl:Class
GO:0002071 biolink:NamedThing glandular epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. got7fsn_ti biological_process owl:Class
GO:0002068 biolink:NamedThing glandular epithelial cell development The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. got7fsn_ti biological_process owl:Class
GO:0072189 biolink:NamedThing ureter development The process whose specific outcome is the progression of the ureter over time, from its formation to the mature structure. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut. got7fsn_ti mah 2010-03-01T01:44:14Z biological_process owl:Class
GO:0072001 biolink:NamedThing renal system development The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels. got7fsn_ti urinary system development|urinary tract development mah 2010-01-25T10:31:00Z biological_process owl:Class
GO:0006791 biolink:NamedThing sulfur utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism. got7fsn_ti sulphur utilization biological_process owl:Class
GO:0042600 biolink:NamedThing egg chorion A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish. got7fsn_ti Note that this term does not refer to the extraembryonic membrane surrounding the embryo of amniote vertebrates as this is an anatomical structure and is therefore not covered by GO. cellular_component owl:Class
GO:0035735 biolink:NamedThing intraciliary transport involved in cilium assembly The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly. got7fsn_ti intraciliary transport involved in cilium morphogenesis|intraflagellar transport involved in cilium morphogenesis|intraflagellar transport bf 2011-03-17T10:55:42Z Reactome:R-HSA-5620924.2 biological_process owl:Class
GO:0017143 biolink:NamedThing insecticide metabolic process The chemical reactions and pathways involving insecticides, chemicals used to kill insects. got7fsn_ti insecticide metabolism GO:0017138 biological_process owl:Class
GO:0098698 biolink:NamedThing postsynaptic specialization assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane. got7fsn_ti dos 2017-04-04T17:22:01Z biological_process owl:Class
GO:0099068 biolink:NamedThing postsynapse assembly The aggregation, arrangement and bonding together of a set of components to form a postsynapse. got7fsn_ti postsynapse biogenesis biological_process owl:Class
GO:0099561 biolink:NamedThing synaptic membrane adhesion to extracellular matrix The binding of a synaptic membrane to the extracellular matrix via adhesion molecules. got7fsn_ti biological_process owl:Class
GO:0030584 biolink:NamedThing sporocarp development The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea. got7fsn_ti fruiting body development biological_process owl:Class
GO:0140243 biolink:NamedThing regulation of translation at synapse Any process that regulates translation occurring at the synapse. got7fsn_ti https://github.com/geneontology/synapse/issues/210 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T09:38:26Z biological_process owl:Class
GO:0061287 biolink:NamedThing mesonephric capsule formation The developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. got7fsn_ti dph 2010-09-02T01:55:03Z biological_process owl:Class
GO:0097619 biolink:NamedThing PTEX complex A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components. got7fsn_ti Plasmodium translocon of exported proteins pr 2014-07-29T16:05:32Z cellular_component owl:Class
GO:0062003 biolink:NamedThing negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity Any process that decreases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. got7fsn_ti dph 2018-02-26T13:23:20Z biological_process owl:Class
GO:0002502 biolink:NamedThing peptide antigen assembly with MHC class I protein complex The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules. got7fsn_ti biological_process owl:Class
GO:0072034 biolink:NamedThing renal vesicle induction Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the renal vesicle. got7fsn_ti positive regulation of nephron formation|nephron induction mah 2010-01-25T02:58:18Z biological_process owl:Class
GO:0071067 biolink:NamedThing alphav-beta3 integrin-ADAM23 complex A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM23. got7fsn_ti ITGAV-ITGB3-ADAM23 complex mah 2009-11-03T04:04:40Z cellular_component owl:Class
GO:1990303 biolink:NamedThing UBR1-RAD6 ubiquitin ligase complex A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes. got7fsn_ti UBR1-RAD6 complex This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay). bhm 2014-03-03T21:43:49Z cellular_component owl:Class
GO:0098584 biolink:NamedThing host cell synaptic vesicle A secretory organelle of a host cell, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. got7fsn_ti dos 2014-01-24T13:14:13Z cellular_component owl:Class
GO:0044221 biolink:NamedThing host cell synapse The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication. got7fsn_ti jl 2009-11-12T03:03:59Z cellular_component owl:Class
GO:0031597 biolink:NamedThing cytosolic proteasome complex A proteasome complex found in the cytosol of a cell. got7fsn_ti cellular_component owl:Class
GO:0060203 biolink:NamedThing clathrin-sculpted glutamate transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle. got7fsn_ti clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted glutamate constitutive secretory pathway transport vesicle membrane cellular_component owl:Class
GO:0055045 biolink:NamedThing antipodal cell degeneration The process in which the antipodal cells undergo programmed cell death. got7fsn_ti biological_process owl:Class
GO:0009336 biolink:NamedThing sulfate adenylyltransferase complex (ATP) An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP. got7fsn_ti sulphate adenylyltransferase complex (ATP) cellular_component owl:Class
GO:0070550 biolink:NamedThing rDNA condensation The process in which the chromatin structure of the rDNA repeats is compacted. In S. cerevisiae, condensation and resolution of the rDNA occurs during anaphase. got7fsn_ti rDNA packaging biological_process owl:Class
GO:1990061 biolink:NamedThing bacterial degradosome The degradosome is a protein complex playing a key role in mRNA degradation and RNA processing. It includes a RNA helicase, a 3'-5' phosphate-dependent PNPase and a RNase E bound-enolase. got7fsn_ti bhm 2013-03-20T13:51:49Z cellular_component owl:Class
GO:0003066 biolink:NamedThing positive regulation of heart rate by norepinephrine The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction. got7fsn_ti norepinephrine cardiac chronotropy|positive regulation of heart rate by adrenaline|positive regulation of heart contraction rate by norepinephrine|noradrenaline cardiac chronotropy|noradrenaline regulation of the rate of heart muscle contraction biological_process owl:Class
GO:0021652 biolink:NamedThing rhombomere 1 formation The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0021651 biolink:NamedThing rhombomere 1 morphogenesis The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0021679 biolink:NamedThing cerebellar molecular layer development The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. got7fsn_ti biological_process owl:Class
GO:0021879 biolink:NamedThing forebrain neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain. got7fsn_ti biological_process owl:Class
GO:0000813 biolink:NamedThing ESCRT I complex An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. got7fsn_ti endosomal sorting complex required for transport cellular_component owl:Class
GO:0030895 biolink:NamedThing apolipoprotein B mRNA editing enzyme complex Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP). got7fsn_ti apoB mRNA editing enzyme complex|APOBEC cellular_component owl:Class
GO:0051838 biolink:NamedThing cytolysis by host of symbiont cells The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0052337 biolink:NamedThing modification by host of symbiont membrane The process in which an organism effects a change in the structure or function of a symbiont cellular membrane. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti modification by host of symbiont cell membrane biological_process owl:Class
GO:0004713 biolink:NamedThing protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. got7fsn_ti protein-tyrosine kinase activity GO:0004718 Reactome:R-HSA-5654545|Reactome:R-HSA-445076|Reactome:R-HSA-2130194|Reactome:R-HSA-5655301|Reactome:R-HSA-9006323|Reactome:R-HSA-983707|Reactome:R-HSA-5218809|Reactome:R-HSA-9706344|Reactome:R-HSA-5654151|Reactome:R-HSA-9665705|Reactome:R-HSA-9625487|Reactome:R-HSA-5357429|Reactome:R-HSA-388833|Reactome:R-HSA-170156|Reactome:R-HSA-1433418|Reactome:R-HSA-8876246|Reactome:R-HSA-212710|Reactome:R-HSA-202174|Reactome:R-HSA-190429|Reactome:R-HSA-190388|Reactome:R-HSA-389083|Reactome:R-HSA-9021609|Reactome:R-HSA-9037040|Reactome:R-HSA-9032532|Reactome:R-HSA-8874078|Reactome:R-HSA-8853325|Reactome:R-HSA-1963581|Reactome:R-HSA-8937728|Reactome:R-HSA-909730|Reactome:R-HSA-1470009|Reactome:R-HSA-190385|Reactome:R-HSA-399934|Reactome:R-HSA-1248694|Reactome:R-HSA-8853315|Reactome:R-HSA-9032601|Reactome:R-HSA-372693|Reactome:R-HSA-879907|Reactome:R-HSA-2730860|Reactome:R-HSA-8874080|Reactome:R-HSA-2586555|Reactome:R-HSA-8857555|Reactome:R-HSA-9613023|Reactome:R-HSA-3928627|Reactome:R-HSA-1839110|RHEA:10596|Reactome:R-HSA-9029151|Reactome:R-HSA-418163|Reactome:R-HSA-202216|Reactome:R-HSA-8851890|Reactome:R-HSA-1433488|Reactome:R-HSA-2029459|Reactome:R-HSA-9604767|Reactome:R-HSA-452122|Reactome:R-HSA-5655268|Reactome:R-HSA-8948143|Reactome:R-HSA-5654631|Reactome:R-HSA-2012073|Reactome:R-HSA-909732|Reactome:R-HSA-8847977|Reactome:R-HSA-8848436|Reactome:R-HSA-183058|Reactome:R-HSA-389762|Reactome:R-HSA-2395439|Reactome:R-HSA-1250195|Reactome:R-HSA-5218642|Reactome:R-HSA-1433454|Reactome:R-HSA-4420121|Reactome:R-HSA-202245|Reactome:R-HSA-8849068|Reactome:R-HSA-9006332|Reactome:R-HSA-2038387|Reactome:R-HSA-1839065|Reactome:R-HSA-354073|Reactome:R-HSA-389354|Reactome:R-HSA-191636|Reactome:R-HSA-2033485|Reactome:R-HSA-1250315|Reactome:R-HSA-2424484|Reactome:R-HSA-3928583|Reactome:R-HSA-9665709|Reactome:R-HSA-171011|Reactome:R-HSA-8874082|Reactome:R-HSA-1295609|Reactome:R-HSA-2029989|Reactome:R-HSA-2730882|Reactome:R-HSA-8853313|Reactome:R-HSA-5655270|Reactome:R-HSA-2033488|Reactome:R-HSA-1472121|Reactome:R-HSA-4420117|Reactome:R-HSA-5624486|Reactome:R-HSA-1524186|Reactome:R-HSA-9026502|Reactome:R-HSA-9698005|Reactome:R-HSA-1963582|Reactome:R-HSA-8875451|Reactome:R-HSA-8848124|Reactome:R-HSA-445091|Reactome:R-HSA-419646|Reactome:R-HSA-190408|Reactome:R-HSA-8848758|Reactome:R-HSA-9664275|Reactome:R-HSA-983703|Reactome:R-HSA-5637795|Reactome:R-HSA-8851933|Reactome:R-HSA-5655278|Reactome:R-HSA-8849042|Reactome:R-HSA-9034814|Reactome:R-HSA-5218851|Reactome:R-HSA-391866|Reactome:R-HSA-2029449|Reactome:R-HSA-9024726|Reactome:R-HSA-9673761|Reactome:R-HSA-9664278|Reactome:R-HSA-8857583|Reactome:R-HSA-5218828|Reactome:R-HSA-9698003|Reactome:R-HSA-2671850|Reactome:R-HSA-9026510|Reactome:R-HSA-5686587|Reactome:R-HSA-5655341|Reactome:R-HSA-2023455|Reactome:R-HSA-202168|Reactome:R-HSA-2038944|Reactome:R-HSA-5654607|Reactome:R-HSA-2395801|Reactome:R-HSA-909726|Reactome:R-HSA-9032854|Reactome:R-HSA-982807|Reactome:R-HSA-399947|Reactome:R-HSA-5654575|Reactome:R-HSA-879925|Reactome:R-HSA-9664976|Reactome:R-HSA-445084|Reactome:R-HSA-9634390|Reactome:R-HSA-9703437|Reactome:R-HSA-9672173|Reactome:R-HSA-9606159|Reactome:R-HSA-3928580|EC:2.7.10.2|Reactome:R-HSA-5654578|Reactome:R-HSA-9665032|Reactome:R-HSA-9027273|Reactome:R-HSA-182969|Reactome:R-HSA-6784319|Reactome:R-HSA-205289|Reactome:R-HSA-2396594|Reactome:R-HSA-9012650|Reactome:R-HSA-9034875|Reactome:R-HSA-2671742|Reactome:R-HSA-909718|Reactome:R-HSA-374701|Reactome:R-HSA-5654605|Reactome:R-HSA-5655243|Reactome:R-HSA-2033486|Reactome:R-HSA-190427|Reactome:R-HSA-2730862|Reactome:R-HSA-8867041|Reactome:R-HSA-170991|Reactome:R-HSA-2671829|Reactome:R-HSA-9665411|Reactome:R-HSA-191062|Reactome:R-HSA-2730833|Reactome:R-HSA-9673756|Reactome:R-HSA-5621355|Reactome:R-HSA-9703438|Reactome:R-HSA-5621363|Reactome:R-HSA-9664588|Reactome:R-HSA-2586553|Reactome:R-HSA-5654149|Reactome:R-HSA-9665389|Reactome:R-HSA-114600|Reactome:R-HSA-210291|Reactome:R-HSA-8983872|Reactome:R-HSA-8848873|Reactome:R-HSA-1225960|Reactome:R-HSA-1251922|Reactome:R-HSA-873922|Reactome:R-HSA-1225952|Reactome:R-HSA-8848818|Reactome:R-HSA-202233|Reactome:R-HSA-432129|Reactome:R-HSA-2029453|Reactome:R-HSA-452100|Reactome:R-HSA-8848005|Reactome:R-HSA-5654428|Reactome:R-HSA-5637796|Reactome:R-HSA-8855237|Reactome:R-HSA-8942607|Reactome:R-HSA-174164|Reactome:R-HSA-2012082|Reactome:R-HSA-2424487|Reactome:R-HSA-3215391|Reactome:R-HSA-2454239|Reactome:R-HSA-9033284|Reactome:R-HSA-202165|Reactome:R-HSA-2428926|Reactome:R-HSA-6790087|Reactome:R-HSA-4420128|Reactome:R-HSA-2424486|Reactome:R-HSA-8857577|Reactome:R-HSA-3928578|Reactome:R-HSA-9026890|Reactome:R-HSA-5683930|Reactome:R-HSA-8964252|Reactome:R-HSA-9026579|Reactome:R-HSA-8849032|Reactome:R-HSA-418872|Reactome:R-HSA-373747|Reactome:R-HSA-373750|Reactome:R-HSA-388831|Reactome:R-HSA-873919|Reactome:R-HSA-5218806|Reactome:R-HSA-5218640|Reactome:R-HSA-451942|Reactome:R-HSA-2201322|Reactome:R-HSA-5654582|Reactome:R-HSA-1248655|Reactome:R-HSA-912629|Reactome:R-HSA-452097|Reactome:R-HSA-9034714|Reactome:R-HSA-6806974|Reactome:R-HSA-1888198|Reactome:R-HSA-9032426|Reactome:R-HSA-8848975|Reactome:R-HSA-2033490|Reactome:R-HSA-202307|Reactome:R-HSA-429441|Reactome:R-HSA-8848776|Reactome:R-HSA-2012087|Reactome:R-HSA-9664261|Reactome:R-HSA-9666425|Reactome:R-HSA-6784006|Reactome:R-HSA-9027425|Reactome:R-HSA-391865|Reactome:R-HSA-879909|Reactome:R-HSA-8857925|Reactome:R-HSA-9670412|Reactome:R-HSA-186786|Reactome:R-HSA-1168394|Reactome:R-HSA-9612085|Reactome:R-HSA-9606163|Reactome:R-HSA-5218830|Reactome:R-HSA-9672175|Reactome:R-HSA-389086|Reactome:R-HSA-429449|Reactome:R-HSA-1839098|Reactome:R-HSA-1169421|Reactome:R-HSA-1839112|Reactome:R-HSA-190413|Reactome:R-HSA-210872|Reactome:R-HSA-5218812|Reactome:R-HSA-9699578|Reactome:R-HSA-2029984|Reactome:R-HSA-170070|Reactome:R-HSA-3928648|Reactome:R-HSA-3928610|Reactome:R-HSA-4093332|Reactome:R-HSA-9011241|Reactome:R-HSA-9669890|Reactome:R-HSA-5654655|Reactome:R-HSA-2404193|Reactome:R-HSA-2730851|Reactome:R-HSA-434836|Reactome:R-HSA-5654408|Reactome:R-HSA-1295540|Reactome:R-HSA-5654634|Reactome:R-HSA-443817|Reactome:R-HSA-873924|Reactome:R-HSA-1433506|Reactome:R-HSA-5655284|Reactome:R-HSA-1963586|Reactome:R-HSA-5654407|Reactome:R-HSA-8848726|Reactome:R-HSA-983709|Reactome:R-HSA-2730843|Reactome:R-HSA-5654418|Reactome:R-HSA-5654397|Reactome:R-HSA-8875817|Reactome:R-HSA-445085|Reactome:R-HSA-9669911|Reactome:R-HSA-4420206|Reactome:R-HSA-9665704|Reactome:R-HSA-873918|Reactome:R-HSA-5607750|Reactome:R-HSA-2730886|Reactome:R-HSA-1671691|Reactome:R-HSA-8853309|Reactome:R-HSA-909729|Reactome:R-HSA-9612996|Reactome:R-HSA-8849102|Reactome:R-HSA-9027272|Reactome:R-HSA-9606162|Reactome:R-HSA-2404199|Reactome:R-HSA-1250348|Reactome:R-HSA-1982066|Reactome:R-HSA-1307963|Reactome:R-HSA-2730884|Reactome:R-HSA-2730888|Reactome:R-HSA-190326|Reactome:R-HSA-5654628|Reactome:R-HSA-508282|Reactome:R-HSA-9670418|Reactome:R-HSA-2730858|Reactome:R-HSA-9018572|Reactome:R-HSA-8848077|Reactome:R-HSA-354124|Reactome:R-HSA-399946|Reactome:R-HSA-391871|Reactome:R-HSA-391156|Reactome:R-HSA-1839067|Reactome:R-HSA-9706350|Reactome:R-HSA-5654653|Reactome:R-HSA-9603420|Reactome:R-HSA-1247844|Reactome:R-HSA-8849463|Reactome:R-HSA-9028728|Reactome:R-HSA-377640|Reactome:R-HSA-2197698|Reactome:R-HSA-428888|Reactome:R-HSA-5218820|Reactome:R-HSA-5607745|Reactome:R-HSA-5654147|Reactome:R-HSA-380780|Reactome:R-HSA-2454208|Reactome:R-HSA-8876948|Reactome:R-HSA-9680248|Reactome:R-HSA-5621370|Reactome:R-HSA-3928604|Reactome:R-HSA-8937807|Reactome:R-HSA-5690702|Reactome:R-HSA-177934|Reactome:R-HSA-2395412|Reactome:R-HSA-2023460|Reactome:R-HSA-8937844|Reactome:R-HSA-5654222|Reactome:R-HSA-2029268|Reactome:R-HSA-1433542|Reactome:R-HSA-202291|Reactome:R-HSA-112333|Reactome:R-HSA-68954|Reactome:R-HSA-177930|Reactome:R-HSA-8848606|Reactome:R-HSA-3928594|Reactome:R-HSA-8964242|Reactome:R-HSA-69195|Reactome:R-HSA-9029155|Reactome:R-HSA-9026464|Reactome:R-HSA-8876230|Reactome:R-HSA-9695834|Reactome:R-HSA-8956659|Reactome:R-HSA-177937|Reactome:R-HSA-418859|Reactome:R-HSA-202248|Reactome:R-HSA-5654587 molecular_function owl:Class
CHEBI:18059 biolink:NamedThing got7fsn_ti owl:Class
GO:0009347 biolink:NamedThing aspartate carbamoyltransferase complex A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides. got7fsn_ti Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. cellular_component owl:Class
GO:0048443 biolink:NamedThing stamen development The process whose specific outcome is the progression of the stamen over time, from its formation to the mature structure. got7fsn_ti GO:0048425 biological_process owl:Class
GO:0016572 biolink:NamedThing histone phosphorylation The modification of histones by addition of phosphate groups. got7fsn_ti biological_process owl:Class
GO:0016191 biolink:NamedThing synaptic vesicle uncoating The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane. got7fsn_ti synaptic vesicle coat depolymerization|synaptic vesicle coat protein depolymerization biological_process owl:Class
GO:0048488 biolink:NamedThing synaptic vesicle endocytosis A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. got7fsn_ti synaptic vesicle retrieval https://github.com/geneontology/synapse/issues/230 GO:0008099 biological_process owl:Class
GO:0005854 biolink:NamedThing nascent polypeptide-associated complex A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome. got7fsn_ti NAC|NACA cellular_component owl:Class
GO:0043314 biolink:NamedThing negative regulation of neutrophil degranulation Any process that stops, prevents, or reduces the rate of neutrophil degranulation. got7fsn_ti inhibition of neutrophil degranulation|down regulation of neutrophil degranulation|down-regulation of neutrophil degranulation|downregulation of neutrophil degranulation|negative regulation of neutrophil granule exocytosis biological_process owl:Class
GO:0003189 biolink:NamedThing aortic valve formation The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti dph 2009-10-08T01:05:44Z biological_process owl:Class
GO:0003180 biolink:NamedThing aortic valve morphogenesis The process in which the structure of the aortic valve is generated and organized. got7fsn_ti dph 2009-10-08T11:29:42Z biological_process owl:Class
GO:0099174 biolink:NamedThing regulation of presynapse organization Any process that modulates the physical form of a presynapse. got7fsn_ti regulation of presynapse organisation|regulation of presynapse organization and biogenesis|regulation of presynapse structure biological_process owl:Class
GO:1990015 biolink:NamedThing ensheathing process A cell projection (often from glial cells such as Schwann cells) that surrounds an unmyelinated axon or cell soma. got7fsn_ti ensheathing process of Schwann cell pr 2012-12-19T09:42:15Z NIF_Subcellular:sao1376748732 cellular_component owl:Class
GO:0007419 biolink:NamedThing ventral cord development The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms. got7fsn_ti biological_process owl:Class
GO:0015423 biolink:NamedThing ABC-type maltose transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in). got7fsn_ti ABC-type maltose transporter|ATP-dependent maltose transmembrane transporter activity|maltose-transporting ATPase activity|ATPase-coupled maltose transmembrane transporter activity|maltose ABC transporter|maltooligosaccharide-importing ATPase activity EC:7.5.2.1|RHEA:22132|MetaCyc:3.6.3.19-RXN molecular_function owl:Class
GO:1904981 biolink:NamedThing maltose transmembrane transport The process in which maltose is transported across a membrane. got7fsn_ti vw 2016-02-28T21:14:04Z biological_process owl:Class
GO:0097094 biolink:NamedThing craniofacial suture morphogenesis The process in which any suture between cranial and/or facial bones is generated and organized. got7fsn_ti pr 2011-07-05T02:51:54Z biological_process owl:Class
GO:1990013 biolink:NamedThing presynaptic grid A hexagonal array of electron dense particles attached to the cytoplasmic face of the presynaptic membrane. got7fsn_ti pre-synaptic grid pr 2012-12-13T09:00:35Z NIF_Subcellular:sao1730664005 cellular_component owl:Class
GO:0048786 biolink:NamedThing presynaptic active zone A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. got7fsn_ti presynaptic specialization|pre-synaptic active zone component|pre-synaptic active zone NIF_Subcellular:sao792027222 cellular_component owl:Class
GO:0010152 biolink:NamedThing pollen maturation The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains. got7fsn_ti biological_process owl:Class
GO:1904173 biolink:NamedThing regulation of histone demethylase activity (H3-K4 specific) Any process that modulates the frequency, rate or extent of histone demethylase activity (H3-K4 specific). got7fsn_ti dph 2015-04-24T19:29:32Z biological_process owl:Class
GO:0030916 biolink:NamedThing otic vesicle formation The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear. got7fsn_ti otocyst biosynthesis|otocyst formation biological_process owl:Class
GO:0030080 biolink:NamedThing B875 antenna complex Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm. got7fsn_ti LH1 complex|light harvesting complex I cellular_component owl:Class
GO:0030078 biolink:NamedThing light-harvesting complex, core complex Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria. got7fsn_ti cellular_component owl:Class
GO:0090540 biolink:NamedThing bacterial cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria. got7fsn_ti bacterial cellulose biosynthesis tb 2013-02-11T16:32:44Z biological_process owl:Class
GO:0120260 biolink:NamedThing ciliary microtubule quartet A set of four specialized microtubules that originates from the basal bodies and wraps around the ciliary pocket membrane, likely supporting its distinct flask shape. got7fsn_ti ciliary MtQ https://github.com/geneontology/go-ontology/issues/20035 Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. krc 2020-09-29T16:22:22Z cellular_component owl:Class
GO:0035905 biolink:NamedThing ascending aorta development The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:02:01Z biological_process owl:Class
GO:0004917 biolink:NamedThing interleukin-7 receptor activity Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-7R|IL-7 receptor activity molecular_function owl:Class
GO:0038111 biolink:NamedThing interleukin-7-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-7-mediated signalling pathway|IL-7-mediated signaling pathway bf 2012-03-22T10:19:27Z biological_process owl:Class
GO:0071910 biolink:NamedThing determination of liver left/right asymmetry Determination of the asymmetric location of the liver with respect to the left and right halves of the organism. got7fsn_ti mah 2010-09-22T10:26:47Z biological_process owl:Class
GO:0120102 biolink:NamedThing bacterial-type flagellum secretion apparatus A part of the bacterial-type flagellum that is located at the cytoplasmic side of the MS ring and composed of six membrane proteins (FlhA, FlhB, FliP, FliQ, FliR, and FliO, or orthologs thereof) and three soluble proteins (FliI, FliH, and FliJ, or orthologs thereof) in the cytoplasm. It is responsible for secretion of flagellar type III protein substrates, including the proteins of the flagellar rod, hook, and filament. got7fsn_ti bacterial-type flagellum export apparatus krc 2017-10-03T16:13:24Z cellular_component owl:Class
GO:0009425 biolink:NamedThing bacterial-type flagellum basal body One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor. got7fsn_ti flagellin-based flagellum basal body|flagellar basal body cellular_component owl:Class
GO:0042175 biolink:NamedThing nuclear outer membrane-endoplasmic reticulum membrane network The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane. got7fsn_ti nuclear envelope-endoplasmic reticulum network|nuclear envelope-ER network|NE-ER continuum|nuclear membrane-ER network|nuclear envelope-endoplasmic reticulum continuum|nuclear membrane-endoplasmic reticulum continuum|NE-ER network cellular_component owl:Class
GO:0004169 biolink:NamedThing dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. got7fsn_ti dolichol phosphomannose-protein mannosyltransferase activity|dolichyl-phosphate-mannose-protein O-mannosyltransferase activity|dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity|protein O-mannosyltransferase activity|protein O-D-mannosyltransferase activity|O-glycoside mannosyltransferase Note that this activity has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. Reactome:R-HSA-5615604|EC:2.4.1.109|Reactome:R-HSA-5615556|Reactome:R-HSA-5615637|MetaCyc:2.4.1.109-RXN molecular_function owl:Class
GO:0035269 biolink:NamedThing protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage. got7fsn_ti protein amino acid O-linked mannosylation biological_process owl:Class
GO:0080136 biolink:NamedThing priming of cellular response to stress The process that enables cells to respond in a more rapid and robust manner than nonprimed cells to much lower levels of a stimulus indicating the organism is under stress. got7fsn_ti priming of stress response|priming of response to stress dhl 2009-05-06T05:05:15Z biological_process owl:Class
GO:0034099 biolink:NamedThing luminal surveillance complex A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins. got7fsn_ti cellular_component owl:Class
GO:1903962 biolink:NamedThing arachidonate transmembrane transporter activity Enables the transfer of arachidonate from one side of a membrane to the other. got7fsn_ti arachidonic acid transporter activity|arachidonate transporter activity An example of this is S100A9 in human (P06702) in PMID:15642721 (inferred from direct assay). bhm 2015-02-25T15:51:12Z molecular_function owl:Class
GO:0031453 biolink:NamedThing positive regulation of heterochromatin assembly Any process that activates or increases the frequency, rate or extent of heterochromatin formation. got7fsn_ti stimulation of heterochromatin formation|upregulation of heterochromatin formation|up regulation of heterochromatin formation|activation of heterochromatin formation|positive regulation of heterochromatin formation|up-regulation of heterochromatin formation biological_process owl:Class
GO:0051884 biolink:NamedThing regulation of timing of anagen Any process that modulates the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. got7fsn_ti regulation of anagen biological_process owl:Class
GO:0090689 biolink:NamedThing cleavage furrow leading edge The 'trough' of the cleavage furrow. This is the part of the cleavage furrow closest to the contractile ring. got7fsn_ti tb 2016-07-26T16:00:10Z cellular_component owl:Class
GO:0032154 biolink:NamedThing cleavage furrow The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm. got7fsn_ti While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists. Wikipedia:Cleavage_furrow cellular_component owl:Class
GO:0021997 biolink:NamedThing neural plate axis specification The pattern specification process in which the axes of the nervous system are established. got7fsn_ti neural plate axis determination biological_process owl:Class
GO:0060896 biolink:NamedThing neural plate pattern specification The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate. got7fsn_ti dph 2009-08-13T02:06:27Z biological_process owl:Class
GO:1902673 biolink:NamedThing left posteriolateral basal body Any ciliary basal body that is part of a left posteriolateral flagellum found in Giardia species (trophozoite stage). got7fsn_ti ciliary basal body of left posteriolateral flagellum|cilium basal body of left posteriolateral flagellum|microtubule basal body of left posteriolateral cilium|ciliary basal body of left posterolateral cilium|cilium basal body of left posteriolateral cilium|microtubule basal body of left posterolateral cilium|microtubule basal body of left posterolateral flagellum|cilium basal body of left posterolateral cilium|cilial basal body of left posteriolateral cilium|cilial basal body of left posteriolateral flagellum|microtubule basal body of left posteriolateral flagellum|ciliary basal body of left posteriolateral cilium|cilial basal body of left posterolateral cilium|ciliary basal body of left posterolateral flagellum|left posteriolateral flagellum ciliary basal body|cilium basal body of left posterolateral flagellum|cilial basal body of left posterolateral flagellum Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T14:49:25Z cellular_component owl:Class
GO:1990677 biolink:NamedThing mitochondrial inner membrane assembly complex A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion. got7fsn_ti mitochondrion inner membrane assembly complex|inner membrane assembly complex|INAC complex An example of this is INA22 in Saccharomyces cerevisiae (P40576) in PMID:24942160 (inferred from direct assay/mutant phenotype/etc.). bhm 2015-03-02T13:14:52Z cellular_component owl:Class
GO:0014036 biolink:NamedThing neural crest cell fate specification The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0031673 biolink:NamedThing H zone A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments. got7fsn_ti H band|H disc Wikipedia:Sarcomere#bands cellular_component owl:Class
GO:0007566 biolink:NamedThing embryo implantation Attachment of the blastocyst to the uterine lining. got7fsn_ti blastocyst implantation biological_process owl:Class
GO:0015648 biolink:NamedThing lipid-linked peptidoglycan transporter activity Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells. got7fsn_ti lipid-linked murein transporter activity molecular_function owl:Class
GO:0015836 biolink:NamedThing lipid-linked peptidoglycan transport The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti lipid-linked murein transport biological_process owl:Class
GO:0090651 biolink:NamedThing apical cytoplasm The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells. got7fsn_ti tb 2015-07-01T15:46:19Z cellular_component owl:Class
GO:0045177 biolink:NamedThing apical part of cell The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. got7fsn_ti apical region of cell cellular_component owl:Class
GO:1904048 biolink:NamedThing regulation of spontaneous neurotransmitter secretion Any process that modulates the frequency, rate or extent of spontaneous neurotransmitter secretion. got7fsn_ti regulation of stimulus-independent neurotransmitter secretion An example of this is PARK2 / parkin in human (O60260) in PMID:22314364 (inferred from mutant phenotype). pad 2015-03-17T10:37:11Z biological_process owl:Class
GO:0098814 biolink:NamedThing spontaneous synaptic transmission The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential. got7fsn_ti basal synaptic transmission This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs). biological_process owl:Class
GO:0001711 biolink:NamedThing endodermal cell fate commitment The cell differentiation process that results in commitment of a cell to become part of the endoderm. got7fsn_ti endoderm cell fate commitment biological_process owl:Class
GO:0035987 biolink:NamedThing endodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. got7fsn_ti endoderm cell differentiation bf 2011-08-25T04:50:36Z biological_process owl:Class
GO:1901261 biolink:NamedThing regulation of sorocarp spore cell differentiation Any process that modulates the frequency, rate or extent of sorocarp spore cell differentiation. got7fsn_ti jl 2012-08-15T09:44:30Z biological_process owl:Class
GO:0038143 biolink:NamedThing ERBB3:ERBB2 complex A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. got7fsn_ti NRG1/2:ERBB3:ERBB2|EGFR:ERBB2 heterodimer bf 2012-03-30T02:16:56Z cellular_component owl:Class
GO:0071123 biolink:NamedThing alpha9-beta1 integrin-VEGF-C complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor C. got7fsn_ti ITGA9-ITGB1-VEGFC complex mah 2009-11-13T02:22:27Z cellular_component owl:Class
GO:0061606 biolink:NamedThing N-terminal protein amino acid propionylation The propionylation of the N-terminal amino acid of proteins. got7fsn_ti dph 2014-02-11T14:13:05Z biological_process owl:Class
GO:0045626 biolink:NamedThing negative regulation of T-helper 1 cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 1 cell differentiation. got7fsn_ti down-regulation of T-helper 1 cell differentiation|down regulation of T-helper 1 cell differentiation|downregulation of T-helper 1 cell differentiation|negative regulation of T-helper 1 cell development|inhibition of T-helper 1 cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0042088 biolink:NamedThing T-helper 1 type immune response An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin. got7fsn_ti Th1 immune response biological_process owl:Class
GO:0048195 biolink:NamedThing Golgi membrane priming complex assembly The aggregation, arrangement and bonding together of a set of components to form a membrane priming complex. An incoming coat component recognizes both GTPase and a membrane protein to form the priming complex. got7fsn_ti formation of dictyosome membrane priming complex|formation of Golgi membrane priming complex biological_process owl:Class
GO:0060491 biolink:NamedThing regulation of cell projection assembly Any process that modulates the rate, frequency, or extent of cell projection assembly. got7fsn_ti regulation of cell projection formation biological_process owl:Class
GO:0097457 biolink:NamedThing hippocampal mossy fiber Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal. got7fsn_ti pr 2012-12-19T16:51:57Z NIF_Subcellular:nlx_subcell_100312 cellular_component owl:Class
CL:0001033 biolink:NamedThing got7fsn_ti owl:Class
GO:0032179 biolink:NamedThing germ tube The slender tubular outgrowth first produced by most spores in germination. got7fsn_ti Wikipedia:Germ_tube cellular_component owl:Class
GO:0070790 biolink:NamedThing phialide development The process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips. got7fsn_ti development of secondary sterigmata mah 2009-07-08T02:32:30Z biological_process owl:Class
GO:0070787 biolink:NamedThing conidiophore development The process whose specific outcome is the progression of the conidiophore over time, from its formation to the mature structure. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. got7fsn_ti mah 2009-07-08T01:30:36Z biological_process owl:Class
GO:0036478 biolink:NamedThing L-dopa decarboxylase activator activity Interacts with and increases L-dopa decarboxylase activity. got7fsn_ti DDC activator activity GO:0036478 is reserved for cases when the activator directly interacts with L-dopa decarboxylase. When activation of L-dopa decarboxylase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'positive regulation of L-dopa decarboxylase activity ; GO:1903200'. bf 2014-07-24T10:10:51Z molecular_function owl:Class
GO:0036468 biolink:NamedThing L-dopa decarboxylase activity Catalysis of the reaction: L-dopa + H+ = CO2 + dopamine. got7fsn_ti DDC activity|4-dihydroxyl-L-phenylalanine decarboxylase activity|DOPA decarboxylase activity bf 2014-07-21T09:22:24Z RHEA:12272 molecular_function owl:Class
GO:0019209 biolink:NamedThing kinase activator activity Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. got7fsn_ti molecular_function owl:Class
GO:0033674 biolink:NamedThing positive regulation of kinase activity Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. got7fsn_ti stimulation of kinase activity|upregulation of kinase activity|up regulation of kinase activity|up-regulation of kinase activity|kinase activator biological_process owl:Class
GO:0004534 biolink:NamedThing 5'-3' exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. got7fsn_ti Reactome:R-HSA-429845|EC:3.1.13.- molecular_function owl:Class
GO:0150006 biolink:NamedThing urease activator complex A protein complex required for the activation of urease. Activator subunits dissociate before urease has catalytic function. got7fsn_ti cellular_component owl:Class
GO:0043419 biolink:NamedThing urea catabolic process The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. got7fsn_ti urea decomposition|urea breakdown|urea degradation|urea catabolism biological_process owl:Class
GO:0060533 biolink:NamedThing bronchus cartilage morphogenesis The process in which the bronchus cartilage is generated and organized. The bronchus cartilage is the connective tissue of the portion of the airway that connects to the lungs. got7fsn_ti dph 2009-04-10T08:47:41Z biological_process owl:Class
GO:0060434 biolink:NamedThing bronchus morphogenesis The process in which the bronchus is generated and organized. The bronchus is the portion of the airway that connects to the lungs. got7fsn_ti biological_process owl:Class
GO:0009783 biolink:NamedThing photosystem II antenna complex The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs). got7fsn_ti cellular_component owl:Class
GO:0072354 biolink:NamedThing histone kinase activity (H3-T3 specific) Catalysis of the transfer of a phosphate group to the threonine-3 residue of the N-terminal tail of histone H3. got7fsn_ti histone-threonine kinase activity (H3-T3 specific)|histone threonine kinase activity (H3-T3 specific) mah 2010-11-12T04:27:57Z molecular_function owl:Class
GO:0072355 biolink:NamedThing histone H3-T3 phosphorylation The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 3 of the histone. got7fsn_ti mah 2010-11-12T04:28:56Z biological_process owl:Class
GO:0061032 biolink:NamedThing visceral serous pericardium development The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium. got7fsn_ti epicardium development dph 2010-02-09T09:52:49Z biological_process owl:Class
GO:0060039 biolink:NamedThing pericardium development The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery. got7fsn_ti biological_process owl:Class
GO:0045292 biolink:NamedThing mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript. got7fsn_ti nuclear mRNA cis splicing, via U2-type spliceosome|nuclear mRNA cis splicing, via spliceosome|splicing biological_process owl:Class
CHEBI:16947 biolink:NamedThing got7fsn_ti owl:Class
GO:0039705 biolink:NamedThing viral translational readthrough The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons. got7fsn_ti viral stop codon readthrough|viral RNA suppression of termination This term is intended to annotate gene products involved in the process of viral translational readthrough, not viral proteins produced by this translation process. bf 2013-11-25T13:20:37Z VZ:859 biological_process owl:Class
GO:0003968 biolink:NamedThing RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. got7fsn_ti ribonucleic acid replicase activity|phage f2 replicase|Q-beta replicase activity|RNA-dependent RNA polymerase activity|RNA-dependent ribonucleate nucleotidyltransferase activity|RDRP|transcriptase|nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|RNA replicase activity|polymerase L|ribonucleic acid-dependent ribonucleic acid polymerase activity|RNA-directed RNA polymerase activity|ribonucleic synthetase activity|PB2 proteins|ribonucleic replicase activity|PB1 proteins|RNA nucleotidyltransferase (RNA-directed) activity|RNA-dependent RNA replicase activity|RNA synthetase activity|3D polymerase activity Reactome:R-HSA-9681674|Reactome:R-HSA-9681651|Reactome:R-HSA-192916|EC:2.7.7.48|Reactome:R-HSA-168301|MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN|Reactome:R-HSA-9694277|Reactome:R-HSA-9694605|Reactome:R-HSA-192851|Reactome:R-HSA-9685681|Reactome:R-HSA-9694581|Reactome:R-HSA-9682465|Reactome:R-HSA-9694344|Reactome:R-HSA-192624|Reactome:R-HSA-9682563|Reactome:R-HSA-9681840|Reactome:R-HSA-9694549|Reactome:R-HSA-168280|Reactome:R-HSA-192832|Reactome:R-HSA-9694506|Reactome:R-HSA-9694792|Reactome:R-HSA-9685639 molecular_function owl:Class
GO:0001172 biolink:NamedThing transcription, RNA-templated The cellular synthesis of RNA on a template of RNA. got7fsn_ti transcription, RNA-dependent krc 2011-03-14T03:54:46Z biological_process owl:Class
GO:1990018 biolink:NamedThing tail portion of tanycyte Elongated process of a tanycyte, devoid of cytoplasmic extensions, that courses through the hypothalamic nuclei to form small endfoot processes that terminate either on blood vessels or at the pial surface of the brain. A tanycyte is a specialized elongated ventricular ependymal cell. got7fsn_ti tail portion pr 2012-12-19T15:21:20Z NIF_Subcellular:sao1749953771 cellular_component owl:Class
GO:0045694 biolink:NamedThing regulation of embryo sac egg cell differentiation Any process that modulates the frequency, rate or extent of embryo sac egg cell differentiation. got7fsn_ti regulation of female gametophyte egg cell differentiation biological_process owl:Class
GO:0038058 biolink:NamedThing TNFSF11 receptor activity Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function. got7fsn_ti tumor necrosis factor ligand superfamily member 11 receptor activity|RANKL receptor activity bf 2012-01-04T03:31:54Z molecular_function owl:Class
GO:0005507 biolink:NamedThing copper ion binding Binding to a copper (Cu) ion. got7fsn_ti copper/cadmium binding|copper binding molecular_function owl:Class
GO:0045152 biolink:NamedThing antisigma factor binding Binding to an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator. got7fsn_ti antisigma factor antagonist activity molecular_function owl:Class
GO:0099583 biolink:NamedThing neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. got7fsn_ti neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels molecular_function owl:Class
GO:0016060 biolink:NamedThing metarhodopsin inactivation The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it. got7fsn_ti biological_process owl:Class
GO:0021900 biolink:NamedThing ventricular zone cell fate commitment The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons. got7fsn_ti biological_process owl:Class
GO:0030992 biolink:NamedThing intraciliary transport particle B The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa. got7fsn_ti intraflagellar transport particle B|IFT complex B|IFT B complex|intraflagellar transport complex B Note that we deem cilia and microtubule-based flagella to be equivalent. cellular_component owl:Class
GO:0001740 biolink:NamedThing Barr body A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery. got7fsn_ti Wikipedia:Barr_body|NIF_Subcellular:sao1571698684 cellular_component owl:Class
GO:0106232 biolink:NamedThing hydroxyisourate hydrolase complex A hydrolase complex that converts 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline. This is the second step of the three-step enzymatic reaction that degrades uric acid to (S)-allantoin. got7fsn_ti HIUH complex|5-hydroxyisourate hydrolase complex|HIU hydrolase complex hjd 2019-10-31T16:34:19Z cellular_component owl:Class
GO:0033971 biolink:NamedThing hydroxyisourate hydrolase activity Catalysis of the reaction: 5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+). got7fsn_ti 5-hydroxyisourate hydrolase activity|HIUHase activity|5-hydroxyisourate amidohydrolase activity KEGG_REACTION:R06601|MetaCyc:3.5.2.17-RXN|RHEA:23736|EC:3.5.2.17 molecular_function owl:Class
GO:0072117 biolink:NamedThing head kidney formation The developmental process pertaining to the initial formation of the head kidney. The head kidney is a pronephros that consists of fused bilateral lobes located in the anterior part of the kidney. got7fsn_ti mah 2010-02-22T11:17:20Z biological_process owl:Class
GO:1904385 biolink:NamedThing cellular response to angiotensin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. got7fsn_ti sl 2015-06-23T17:27:14Z biological_process owl:Class
GO:0097059 biolink:NamedThing CNTFR-CLCF1 complex A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space. got7fsn_ti sCNTFR-CLC complex pr 2011-05-26T10:43:22Z cellular_component owl:Class
GO:0033104 biolink:NamedThing type VI protein secretion system complex A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence. got7fsn_ti T6SS complex cellular_component owl:Class
GO:0055109 biolink:NamedThing invagination involved in gastrulation with mouth forming second The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation. got7fsn_ti biological_process owl:Class
GO:0044385 biolink:NamedThing integral to membrane of host cell Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell. got7fsn_ti jl 2011-12-13T04:08:03Z cellular_component owl:Class
GO:0061358 biolink:NamedThing negative regulation of Wnt protein secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a Wnt protein from a cell. got7fsn_ti dph 2010-10-08T01:15:15Z biological_process owl:Class
GO:0006267 biolink:NamedThing pre-replicative complex assembly involved in nuclear cell cycle DNA replication The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation. got7fsn_ti pre-replicative complex formation|pre-RC complex assembly|pre-replicative complex assembly|nuclear pre-replicative complex assembly biological_process owl:Class
GO:0000329 biolink:NamedThing fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. got7fsn_ti membrane of vacuole with cell cycle-correlated morphology|fungal-type vacuolar membrane cellular_component owl:Class
GO:0003037 biolink:NamedThing detection of pH by carotid body chemoreceptor signaling The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body. got7fsn_ti detection of pH by carotid body chemoreceptor signalling biological_process owl:Class
GO:0048056 biolink:NamedThing R3/R4 cell differentiation The process in which relatively unspecialized cells acquire the specialized features of R3 and R4 photoreceptors. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0004103 biolink:NamedThing choline kinase activity Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+). got7fsn_ti choline phosphokinase activity|choline-ethanolamine kinase activity|choline kinase (phosphorylating)|ATP:choline phosphotransferase activity MetaCyc:CHOLINE-KINASE-RXN|KEGG_REACTION:R01021|EC:2.7.1.32|Reactome:R-HSA-1483004|RHEA:12837 molecular_function owl:Class
GO:0006657 biolink:NamedThing CDP-choline pathway The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. got7fsn_ti phosphatidylcholine biosynthesis from choline|Kennedy pathway MetaCyc:PWY3O-450 biological_process owl:Class
GO:0060433 biolink:NamedThing bronchus development The biological process whose specific outcome is the progression of a bronchus from an initial condition to its mature state. This process begins with the formation of the bronchus and ends with the mature structure. The bronchus is the portion of the airway that connects to the lungs. got7fsn_ti biological_process owl:Class
GO:0052704 biolink:NamedThing ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide The pathway resulting in the formation of ergothioneine from histidine via a set of steps in which gamma-glutamyl-hercynylcysteine sulfoxide is formed as an intermediate. got7fsn_ti ergothioneine biosynthesis from histidine via N-alpha,N-alpha,N-alpha-trimethyl-L-histidine https://github.com/geneontology/go-ontology/issues/11163 2011-08-05T11:31:52Z Wikipedia:Ergothioneine biological_process owl:Class
GO:0043155 biolink:NamedThing negative regulation of photosynthesis, light reaction Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis. got7fsn_ti down regulation of photosynthesis, light reaction|downregulation of photosynthesis, light reaction|inhibition of photosynthesis, light reaction|down-regulation of photosynthesis, light reaction biological_process owl:Class
GO:0021587 biolink:NamedThing cerebellum morphogenesis The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. got7fsn_ti biological_process owl:Class
GO:1903599 biolink:NamedThing positive regulation of autophagy of mitochondrion Any process that activates or increases the frequency, rate or extent of mitochondrion degradation by autophagy. got7fsn_ti up-regulation of mitophagy|up regulation of mitophagy|upregulation of mitophagy|activation of mitochondrion degradation|upregulation of mitochondrion degradation|up regulation of mitochondrion degradation|activation of mitophagy|up-regulation of mitochondrion degradation|positive regulation of mitochondrial degradation An example of this AMBRA1 - human (Q9C0C7) in PMID:21753002 inferred from direct assay pad 2014-11-10T14:25:53Z biological_process owl:Class
GO:0071077 biolink:NamedThing adenosine 3',5'-bisphosphate transmembrane transporter activity Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other. got7fsn_ti adenosine 3',5'-diphosphate transporter activity|adenosine 3'-phosphate-5'-phosphate transmembrane transporter activity mah 2009-11-06T03:44:14Z molecular_function owl:Class
GO:0071106 biolink:NamedThing adenosine 3',5'-bisphosphate transmembrane transport The process in which adenosine 3',5'-bisphosphate is transported across a membrane. got7fsn_ti adenosine 3',5'-bisphosphate membrane transport|adenosine 3',5'-diphosphate transport|adenosine 3'-phosphate-5'-phosphate transmembrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2009-11-12T10:40:49Z biological_process owl:Class
GO:0010091 biolink:NamedThing trichome branching Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana. got7fsn_ti GO:0048274 biological_process owl:Class
GO:0001706 biolink:NamedThing endoderm formation The formation of the endoderm during gastrulation. got7fsn_ti endoblast formation biological_process owl:Class
GO:0045453 biolink:NamedThing bone resorption The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products. got7fsn_ti Wikipedia:Bone_resorption biological_process owl:Class
GO:0002022 biolink:NamedThing detection of dietary excess The neurological process in which the brain senses excessive caloric intake. got7fsn_ti biological_process owl:Class
GO:0002021 biolink:NamedThing response to dietary excess The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure. got7fsn_ti biological_process owl:Class
GO:0034777 biolink:NamedThing recycling endosome lumen The volume enclosed by the membranes of a recycling endosome. got7fsn_ti cellular_component owl:Class
GO:0021571 biolink:NamedThing rhombomere 5 development The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0070687 biolink:NamedThing macropinocytic cup cytoskeleton The part of the cortical actin cytoskeleton that forms part of a macropinocytic cup. got7fsn_ti crown cytoskeleton mah 2009-06-03T10:59:50Z cellular_component owl:Class
GO:0002807 biolink:NamedThing positive regulation of antimicrobial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis. got7fsn_ti stimulation of antimicrobial peptide biosynthetic process|up regulation of antimicrobial peptide biosynthetic process|activation of antimicrobial peptide biosynthetic process|upregulation of antimicrobial peptide biosynthetic process|up-regulation of antimicrobial peptide biosynthetic process biological_process owl:Class
GO:0070521 biolink:NamedThing alpha4-beta1 integrin-CD82 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD82, a member of the tetraspan family. got7fsn_ti cellular_component owl:Class
GO:0051864 biolink:NamedThing histone H3-methyl-lysine-36 demethylase activity Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone H3K36 demethylase activity|histone-lysine demethylase activity (H3-K36 specific)|[histone-H3]-lysine-36 demethylase activity|histone H3-lysine-36 demethylase activity|histone-lysine(H3-K36) demethylase activity|histone demethylase activity (H3-K36 specific)|histone-lysine (H3-K36) demethylase activity https://github.com/geneontology/go-ontology/issues/21089 molecular_function owl:Class
GO:0070544 biolink:NamedThing histone H3-K36 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone. got7fsn_ti H3K36 demethylation biological_process owl:Class
GO:0045191 biolink:NamedThing regulation of isotype switching Any process that modulates the frequency, rate or extent of isotype switching. got7fsn_ti regulation of class switch recombination|regulation of isotype switch recombination|regulation of class switching biological_process owl:Class
GO:0002377 biolink:NamedThing immunoglobulin production The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti antibody production|immunoglobulin biosynthetic process|immunoglobulin secretion Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0048305|GO:0002378 biological_process owl:Class
GO:0032508 biolink:NamedThing DNA duplex unwinding The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands. got7fsn_ti DNA unwinding|duplex DNA melting Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. biological_process owl:Class
GO:0097107 biolink:NamedThing postsynaptic density assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. got7fsn_ti post-synaptic density assembly|post synaptic density assembly|PSD assembly pr 2011-07-27T05:21:39Z biological_process owl:Class
GO:1904861 biolink:NamedThing excitatory synapse assembly The aggregation, arrangement and bonding together of a set of components to form an excitatory synapse. got7fsn_ti excitatory synapse formation bf 2015-12-17T10:31:26Z biological_process owl:Class
GO:0001755 biolink:NamedThing neural crest cell migration The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. got7fsn_ti biological_process owl:Class
GO:0002432 biolink:NamedThing granuloma formation The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic. got7fsn_ti biological_process owl:Class
GO:0002544 biolink:NamedThing chronic inflammatory response Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. got7fsn_ti biological_process owl:Class
GO:0045035 biolink:NamedThing sensory organ precursor cell division The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron). got7fsn_ti sense organ precursor cell division biological_process owl:Class
GO:0019069 biolink:NamedThing viral capsid assembly The assembly of a virus capsid from its protein subunits. got7fsn_ti biological_process owl:Class
GO:0071664 biolink:NamedThing catenin-TCF7L2 complex A protein complex that contains a catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. got7fsn_ti catenin-TCF4 complex mah 2010-02-12T03:19:16Z cellular_component owl:Class
GO:0098711 biolink:NamedThing iron ion import across plasma membrane The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti ferrous ion import into cell|ferrous iron import into cell|ferrous iron import across plasma membrane|iron ion import into cell|iron import into cell pr 2012-12-20T08:29:00Z GO:0097460|GO:0098707|GO:0097459 biological_process owl:Class
GO:0006164 biolink:NamedThing purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti purine nucleotide biosynthesis|purine nucleotide anabolism|purine nucleotide formation|purine nucleotide synthesis MetaCyc:DENOVOPURINE2-PWY biological_process owl:Class
GO:0022885 biolink:NamedThing bacteriocin transmembrane transporter activity Enables the transfer of a bacteriocin from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0043213 biolink:NamedThing bacteriocin transport The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain. got7fsn_ti biological_process owl:Class
GO:0071691 biolink:NamedThing cardiac muscle thin filament assembly The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in cardiac muscle. got7fsn_ti mah 2010-02-25T03:57:01Z biological_process owl:Class
GO:1990706 biolink:NamedThing MAD1 complex A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). got7fsn_ti MAD1 homodimer bhm 2015-03-17T15:49:16Z cellular_component owl:Class
GO:0007424 biolink:NamedThing open tracheal system development The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster. got7fsn_ti See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'. biological_process owl:Class
GO:0031207 biolink:NamedThing Sec62/Sec63 complex A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p. got7fsn_ti ER protein translocation subcomplex|Sec62/63 complex cellular_component owl:Class
GO:0090624 biolink:NamedThing endoribonuclease activity, cleaving miRNA-paired mRNA Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA. got7fsn_ti tb 2015-01-21T16:28:52Z molecular_function owl:Class
GO:0035279 biolink:NamedThing mRNA cleavage involved in gene silencing by miRNA The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism. got7fsn_ti gene silencing by miRNA, mRNA cleavage|miRNA-mediated gene silencing, mRNA cleavage|mRNA cleavage involved in gene silencing by microRNA biological_process owl:Class
GO:0004159 biolink:NamedThing dihydropyrimidine dehydrogenase (NAD+) activity Catalysis of the reaction: a 5,6-dihydropyrimidine (5,6-dihydrouracil or 5,6-dihydrothymine) + NAD+ = a pyrimidine (uracil or thymine) + NADH + H+. got7fsn_ti 5,6-dihydrouracil:NAD+ oxidoreductase activity|uracil reductase activity|dihydrothymine dehydrogenase (NAD+) activity|pyrimidine reductase activity|thymine reductase activity|dihydrouracil dehydrogenase (NAD+) activity https://github.com/geneontology/go-ontology/issues/21891 EC:1.3.1.1|MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN|RHEA:20189|RHEA:28791 molecular_function owl:Class
GO:0000811 biolink:NamedThing GINS complex A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks. got7fsn_ti Go, Ichi, Ni and San complex cellular_component owl:Class
GO:0020032 biolink:NamedThing basal ring of apical complex An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite. got7fsn_ti lower polar ring of apical complex|posterior polar ring of apical complex|preconoidal ring of apical complex cellular_component owl:Class
GO:0009321 biolink:NamedThing alkyl hydroperoxide reductase complex An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides. got7fsn_ti See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. cellular_component owl:Class
GO:0021668 biolink:NamedThing rhombomere 6 structural organization The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 6 structural organisation biological_process owl:Class
GO:0038198 biolink:NamedThing auxin receptor activity Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone). got7fsn_ti bf 2013-12-05T15:47:42Z molecular_function owl:Class
GO:0010011 biolink:NamedThing auxin binding Binding to auxin, a plant hormone that regulates aspects of plant growth. got7fsn_ti auxin receptor molecular_function owl:Class
GO:0003383 biolink:NamedThing apical constriction The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell. got7fsn_ti dph 2009-12-09T07:30:34Z biological_process owl:Class
GO:0003040 biolink:NamedThing excitation of vasomotor center by aortic body chemoreceptor signaling The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure. got7fsn_ti excitation of vasomotor center by aortic body chemoreceptor signalling biological_process owl:Class
GO:0048055 biolink:NamedThing R2/R5 development The process whose specific outcome is the progression of the R2 and R5 pair of photoreceptors in the eye over time, from their formation to the mature structures. R2 and R5 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0051477 biolink:NamedThing mannosylglycerate transmembrane transporter activity Enables the transfer of a mannosylglycerate from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0051476 biolink:NamedThing mannosylglycerate transport The directed movement of mannosylglycerate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0005630 biolink:NamedThing dityrosine layer of spore wall The outermost layer of the spore wall, as described in Saccharomyces. got7fsn_ti cellular_component owl:Class
GO:2000521 biolink:NamedThing negative regulation of immunological synapse formation Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation. got7fsn_ti negative regulation of formation of immunological synapse ebc 2011-03-23T10:18:19Z biological_process owl:Class
GO:1990913 biolink:NamedThing sperm head plasma membrane The plasma membrane that is part of the head section of a sperm cell. got7fsn_ti sl 2015-12-07T23:14:04Z cellular_component owl:Class
GO:0097524 biolink:NamedThing sperm plasma membrane A plasma membrane that is part of a sperm cell. got7fsn_ti pr 2013-10-18T11:31:17Z cellular_component owl:Class
GO:1905787 biolink:NamedThing regulation of detection of mechanical stimulus involved in sensory perception of touch Any process that modulates the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. got7fsn_ti regulation of perception of touch, sensory transduction of mechanical stimulus|regulation of perception of touch, sensory detection of mechanical stimulus|regulation of tactition, sensory detection of mechanical stimulus|regulation of perception of touch, detection of mechanical stimulus|regulation of sensory detection of mechanical stimulus during perception of touch|regulation of sensory transduction of mechanical stimulus during perception of touch hbye 2017-01-09T15:11:04Z biological_process owl:Class
GO:0035792 biolink:NamedThing host cell postsynaptic membrane A postsynaptic membrane that is part of a host cell. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane. got7fsn_ti other organism post-synaptic membrane|other organism postsynaptic membrane bf 2011-04-08T01:21:20Z cellular_component owl:Class
GO:0072042 biolink:NamedThing regulation of mesenchymal stem cell proliferation involved in nephron morphogenesis Any process that modulates the frequency, rate or extent of mesenchymal stem cell proliferation and contributes to the shaping of a nephron. got7fsn_ti mah 2010-01-25T03:11:26Z biological_process owl:Class
GO:0072090 biolink:NamedThing mesenchymal stem cell proliferation involved in nephron morphogenesis The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population, that contributes to the shaping of a nephron. got7fsn_ti mah 2010-02-08T02:05:54Z biological_process owl:Class
GO:0005520 biolink:NamedThing insulin-like growth factor binding Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. got7fsn_ti IGF binding molecular_function owl:Class
GO:0006415 biolink:NamedThing translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). got7fsn_ti translational complex disassembly|translation termination|protein synthesis termination GO:0006443|GO:0006456 biological_process owl:Class
GO:0006401 biolink:NamedThing RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. got7fsn_ti RNA catabolism|RNA degradation|RNA breakdown biological_process owl:Class
GO:0032591 biolink:NamedThing dendritic spine membrane The portion of the plasma membrane surrounding a dendritic spine. got7fsn_ti cellular_component owl:Class
GO:0032590 biolink:NamedThing dendrite membrane The portion of the plasma membrane surrounding a dendrite. got7fsn_ti cellular_component owl:Class
GO:0061443 biolink:NamedThing endocardial cushion cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell. got7fsn_ti dph 2012-03-13T09:05:38Z biological_process owl:Class
GO:0003197 biolink:NamedThing endocardial cushion development The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves. got7fsn_ti dph 2009-10-08T01:17:43Z biological_process owl:Class
GO:0043656 biolink:NamedThing host intracellular region That space within the plasma membrane of a host cell. got7fsn_ti intracellular region of host|host intracellular cellular_component owl:Class
GO:0003214 biolink:NamedThing cardiac left ventricle morphogenesis The process in which the left cardiac ventricle is generated and organized. got7fsn_ti dph 2009-10-13T09:50:08Z biological_process owl:Class
GO:0070157 biolink:NamedThing mitochondrial prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA in a mitochondrion, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0097711 biolink:NamedThing ciliary basal body-plasma membrane docking The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane. got7fsn_ti anchoring of the basal body to the plasma membrane|ciliary basal body docking Basal bodies in jawed vertebrates appear to first attach to a ciliary vesicle. It is unclear how specific this is to jawed vertebrates or if other organisms also employ this sequence. Some species like Giardia intestinalis do not relocate their basal bodies to the plasma membrane, but have their axonemes extend through the cytosol to then protrude out of the cell to form flagella. pr 2016-08-05T16:12:33Z Reactome:R-HSA-5620912.1 biological_process owl:Class
GO:0030085 biolink:NamedThing PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides. got7fsn_ti cellular_component owl:Class
GO:0070685 biolink:NamedThing macropinocytic cup A cell projection that forms at the site of macropinocytosis, a form of endocytosis that results in the uptake of relatively large amounts of extracellular fluid. The macropinocytic cup membrane selectively excludes certain proteins, such as H36 or PM4C4 in Dictyostelium, and the underlying cytoskeleton is enriched in F-actin and coronin. got7fsn_ti crown mah 2009-06-03T10:18:00Z cellular_component owl:Class
GO:0060892 biolink:NamedThing limb basal epidermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an limb basal epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti dph 2009-08-13T01:41:47Z biological_process owl:Class
GO:2000264 biolink:NamedThing negative regulation of blood coagulation, extrinsic pathway Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway. got7fsn_ti mah 2010-11-23T11:44:42Z biological_process owl:Class
GO:2000747 biolink:NamedThing negative regulation of defecation rhythm Any process that stops, prevents or reduces the frequency, rate or extent of defecation rhythm. got7fsn_ti negative regulation of defecation cycle|negative regulation of defecation motor program|negative regulation of defecation behavior|negative regulation of DMP bf 2011-06-15T03:23:10Z biological_process owl:Class
GO:0030421 biolink:NamedThing defecation The expulsion of feces from the rectum. got7fsn_ti Wikipedia:Defecation biological_process owl:Class
GO:1905798 biolink:NamedThing positive regulation of intraciliary anterograde transport Any process that activates or increases the frequency, rate or extent of intraciliary anterograde transport. got7fsn_ti up regulation of intraflagellar anterograde transport|activation of intraflagellar anterograde transport|positive regulation of intraflagellar anterograde transport|up-regulation of intraciliary anterograde transport|upregulation of intraflagellar anterograde transport|activation of intraciliary anterograde transport|up-regulation of intraflagellar anterograde transport|upregulation of intraciliary anterograde transport|up regulation of intraciliary anterograde transport hbye 2017-01-11T12:56:01Z biological_process owl:Class
GO:1903691 biolink:NamedThing positive regulation of wound healing, spreading of epidermal cells Any process that activates or increases the frequency, rate or extent of wound healing, spreading of epidermal cells. got7fsn_ti up-regulation of wound healing, spreading of epidermal cells|up regulation of wound healing, spreading of epidermal cells|upregulation of wound healing, spreading of epidermal cells|activation of wound healing, spreading of epidermal cells als 2014-12-01T15:54:35Z biological_process owl:Class
GO:0061200 biolink:NamedThing clathrin-sculpted gamma-aminobutyric acid transport vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing gamma-aminobutyric acid transport vesicle. got7fsn_ti clathrin sculpted gamma-aminobutyric acid transport vesicle|clathrin sculpted GABA transport vesicle dph 2010-07-29T10:40:43Z cellular_component owl:Class
GO:0061003 biolink:NamedThing positive regulation of dendritic spine morphogenesis Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. got7fsn_ti dph 2010-01-20T09:36:54Z biological_process owl:Class
GO:0005669 biolink:NamedThing transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. got7fsn_ti cellular_component owl:Class
GO:0035099 biolink:NamedThing hemocyte migration The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo. got7fsn_ti arthropod blood cell migration|hemocyte cell migration biological_process owl:Class
PATO:0015006 biolink:NamedThing got7fsn_ti owl:Class
GO:0097596 biolink:NamedThing ventral disc supernumerary microtubule array A partial left-handed spiral array of microtubules that lies generally dorsal to the main ventral disc microtubule array in Giardia species (trophozoite stage). got7fsn_ti ventral disk supernumerary microtubule array|supernumerary microtubule array Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-04-03T11:25:07Z cellular_component owl:Class
GO:0040007 biolink:NamedThing growth The increase in size or mass of an entire organism, a part of an organism or a cell. got7fsn_ti non-developmental growth|growth pattern See also the biological process term 'cell growth ; GO:0016049'. GO:0048590 biological_process owl:Class
GO:0070240 biolink:NamedThing negative regulation of activated T cell autonomous cell death Any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death. got7fsn_ti down regulation of activated T cell autonomous cell death|negative regulation of activated T cell apoptosis|negative regulation of activated T-lymphocyte autonomous cell death|negative regulation of activated cell autonomous cell death|downregulation of activated T cell autonomous cell death|negative regulation of ACAD|inhibition of activated T cell autonomous cell death|negative regulation of activated T-cell autonomous cell death|negative regulation of activated T lymphocyte autonomous cell death|down-regulation of activated T cell autonomous cell death biological_process owl:Class
GO:0021542 biolink:NamedThing dentate gyrus development The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus. got7fsn_ti biological_process owl:Class
GO:0021766 biolink:NamedThing hippocampus development The progression of the hippocampus over time from its initial formation until its mature state. got7fsn_ti hippocampal formation development biological_process owl:Class
GO:0072221 biolink:NamedThing metanephric distal convoluted tubule development The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter. got7fsn_ti mah 2010-03-18T03:35:27Z biological_process owl:Class
GO:0072235 biolink:NamedThing metanephric distal tubule development The process whose specific outcome is the progression of the metanephric distal tubule over time, from its formation to the mature structure. The metanephric distal tubule is a metanephric nephron tubule that begins at the metanephric macula densa and extends to the metanephric connecting tubule. got7fsn_ti mah 2010-03-18T03:45:37Z biological_process owl:Class
GO:0010099 biolink:NamedThing regulation of photomorphogenesis Any process that modulates the rate or extent of photomorphogenesis. got7fsn_ti biological_process owl:Class
GO:0038163 biolink:NamedThing thrombopoietin-mediated signaling pathway A series of molecular signals initiated by the binding of a thrombopoietin to the thrombopoietin receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti THPO signaling pathway|thrombopoietin receptor signaling pathway|THPO/MPL signaling pathway bf 2012-05-14T02:45:53Z biological_process owl:Class
GO:0060928 biolink:NamedThing atrioventricular node cell development The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state. got7fsn_ti AV node cell development dph 2009-09-29T11:59:26Z biological_process owl:Class
GO:0060922 biolink:NamedThing atrioventricular node cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node. got7fsn_ti AV node cell differentiation dph 2009-09-29T11:07:06Z biological_process owl:Class
GO:0061212 biolink:NamedThing mesonephric juxtaglomerular apparatus development The process whose specific outcome is the progression of the juxtaglomerular apparatus in the mesonephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate. got7fsn_ti dph 2010-08-17T03:27:36Z biological_process owl:Class
GO:0061908 biolink:NamedThing phagophore A disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle. got7fsn_ti isolation membrane dph 2017-06-29T16:59:19Z cellular_component owl:Class
GO:0051913 biolink:NamedThing regulation of synaptic plasticity by chemical substance The process in which a chemical substance modulates synaptic plasticity, the ability of synapses to change as circumstances require. got7fsn_ti regulation of synaptic plasticity by drug biological_process owl:Class
GO:1901629 biolink:NamedThing regulation of presynaptic membrane organization Any process that modulates the frequency, rate or extent of presynaptic membrane organization. got7fsn_ti regulation of presynaptic membrane organisation|regulation of pre-synaptic membrane organization ans 2012-11-15T11:40:32Z biological_process owl:Class
GO:0044852 biolink:NamedThing nonrepetitive DNA condensation The process in which chromatin structure of nonrepetitive regions of DNA is compacted prior to and during mitosis in eukaryotic cells. got7fsn_ti nonrepetitive DNA packaging jl 2014-07-17T14:13:23Z biological_process owl:Class
GO:0005899 biolink:NamedThing insulin receptor complex A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain. got7fsn_ti cellular_component owl:Class
GO:0097413 biolink:NamedThing Lewy body Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein. got7fsn_ti cytoplasmic inclusion pr 2012-11-06T16:26:08Z NIF_Subcellular:sao4933778419 cellular_component owl:Class
GO:0007454 biolink:NamedThing labial disc morphogenesis The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis. got7fsn_ti labial disc metamorphosis biological_process owl:Class
GO:0035217 biolink:NamedThing labial disc development Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis. got7fsn_ti biological_process owl:Class
GO:0051460 biolink:NamedThing negative regulation of corticotropin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of corticotropic hormone from a cell. got7fsn_ti negative regulation of ACTH secretion|down regulation of adrenocorticotropin secretion|downregulation of adrenocorticotropin secretion|negative regulation of adrenotropic hormone secretion|negative regulation of adrenocorticotropic hormone secretion|negative regulation of adrenotropin secretion|down-regulation of adrenocorticotropin secretion|negative regulation of adrenocorticotropin secretion|negative regulation of corticotropic hormone secretion|inhibition of adrenocorticotropin secretion biological_process owl:Class
GO:0030673 biolink:NamedThing axolemma The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness. got7fsn_ti axonal membrane NIF_Subcellular:sao250772229|Wikipedia:Axolemma cellular_component owl:Class
GO:0080186 biolink:NamedThing developmental vegetative growth The increase in size or mass of non-reproductive plant parts. got7fsn_ti dhl 2011-08-17T03:45:53Z biological_process owl:Class
GO:1904417 biolink:NamedThing positive regulation of xenophagy Any process that activates or increases the frequency, rate or extent of xenophagy. got7fsn_ti activation of xenophagy|up regulation of xenophagy|up-regulation of xenophagy|upregulation of xenophagy An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). pad 2015-06-29T12:30:59Z biological_process owl:Class
GO:0140332 biolink:NamedThing lipopolysaccharide transfer activity Removes a lipopolysaccharide (LPS) from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane. got7fsn_ti intermembrane LPS transporter activity|intermembrane lipopolysaccharide transfer activity|lipopolysaccharide carrier activity|intermembrane lipopolysaccharide transporter activity pg 2019-05-13T08:17:35Z molecular_function owl:Class
GO:0015920 biolink:NamedThing lipopolysaccharide transport The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. got7fsn_ti LPS transport biological_process owl:Class
GO:2000063 biolink:NamedThing positive regulation of ureter smooth muscle cell differentiation Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation. got7fsn_ti jl 2010-08-20T01:44:28Z biological_process owl:Class
GO:0010307 biolink:NamedThing acetylglutamate kinase regulator activity Modulates the enzyme activity of acetylglutamate kinase. got7fsn_ti molecular_function owl:Class
GO:0044671 biolink:NamedThing sorocarp spore cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass). got7fsn_ti jl 2012-08-08T13:10:48Z biological_process owl:Class
GO:0048837 biolink:NamedThing sorocarp sorus development The process whose specific outcome is the progression of the sorocarp sorus over time, from its formation to the mature structure. A sorocarp sorus is the spore containing structure of a sorocarp. got7fsn_ti sorocarp spore head formation|sorocarp spore head morphogenesis|sorocarp sorus formation biological_process owl:Class
GO:0070142 biolink:NamedThing synaptic vesicle budding Evagination of a membrane to form a synaptic vesicle. got7fsn_ti biological_process owl:Class
GO:0048489 biolink:NamedThing synaptic vesicle transport The directed movement of synaptic vesicles. got7fsn_ti synaptic vesicle fusion|synaptic vesicle fission|synaptic vesicle trafficking GO:0016181 biological_process owl:Class
GO:0048910 biolink:NamedThing afferent axon development in anterior lateral line nerve The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0048909 biolink:NamedThing anterior lateral line nerve development The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. got7fsn_ti ALLN development|rostral lateral line nerve development|nALL development GO:0021734 biological_process owl:Class
GO:0070148 biolink:NamedThing mitochondrial glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA in a mitochondrion, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0005068 biolink:NamedThing transmembrane receptor protein tyrosine kinase adaptor activity The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. got7fsn_ti transmembrane receptor protein tyrosine kinase adaptor protein activity|transmembrane receptor protein tyrosine kinase docking protein activity GO:0005069 molecular_function owl:Class
GO:0007079 biolink:NamedThing mitotic chromosome movement towards spindle pole The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis. got7fsn_ti mitotic chromosome movement|chromosome movement towards spindle pole during mitosis|chromosome migration to spindle pole during mitosis|sister chromosome movement towards spindle pole during mitosis|mitotic sister chromosome movement towards spindle pole|mitotic chromosome movement to spindle pole GO:0007082 biological_process owl:Class
GO:0090626 biolink:NamedThing plant epidermis morphogenesis The process in which the anatomical structures of the plant epidermis are generated and organized. got7fsn_ti tb 2015-01-29T14:54:03Z biological_process owl:Class
GO:0022624 biolink:NamedThing proteasome accessory complex A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex. got7fsn_ti cellular_component owl:Class
GO:0061407 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus. got7fsn_ti dph 2012-01-12T11:39:10Z biological_process owl:Class
GO:0070301 biolink:NamedThing cellular response to hydrogen peroxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. got7fsn_ti biological_process owl:Class
GO:0015174 biolink:NamedThing basic amino acid transmembrane transporter activity Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. got7fsn_ti basic amino acid permease activity|cationic amino acid transmembrane transporter activity|basic amino acid transporter activity GO:0015326|GO:0005286 Reactome:R-HSA-8932851|Reactome:R-HSA-8959781 molecular_function owl:Class
GO:1990822 biolink:NamedThing basic amino acid transmembrane transport The directed movement of basic amino acids from one side of a membrane to the other. got7fsn_ti vw 2015-08-19T07:47:00Z biological_process owl:Class
GO:0031321 biolink:NamedThing ascospore-type prospore assembly During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane. got7fsn_ti forespore formation|ascospore-type prospore formation biological_process owl:Class
GO:0097650 biolink:NamedThing B axonemal microtubule An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet. got7fsn_ti B tubule pr 2014-09-10T20:43:18Z cellular_component owl:Class
GO:2000237 biolink:NamedThing positive regulation of tRNA processing Any process that activates or increases the frequency, rate or extent of tRNA processing. got7fsn_ti positive regulation of tRNA maturation mah 2010-11-10T12:15:17Z biological_process owl:Class
GO:0001657 biolink:NamedThing ureteric bud development The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0007520 biolink:NamedThing myoblast fusion A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
CL:0000056 biolink:NamedThing got7fsn_ti owl:Class
NCBITaxon:33083 biolink:NamedThing got7fsn_ti owl:Class
GO:2000463 biolink:NamedThing positive regulation of excitatory postsynaptic potential Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. got7fsn_ti positive regulation of excitatory post-synaptic membrane potential|positive regulation of EPSP rl 2011-03-04T02:43:32Z biological_process owl:Class
GO:0035072 biolink:NamedThing ecdysone-mediated induction of salivary gland cell autophagic cell death Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis. got7fsn_ti ecdysone-mediated induction of programmed cell death of salivary gland cells by autophagy|ecdysone-mediated induction of salivary gland cell programmed cell death by autophagy|ecdysone-mediated induction of autophagic cell death of salivary gland cells biological_process owl:Class
GO:0051123 biolink:NamedThing RNA polymerase II preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase. got7fsn_ti RNA polymerase II transcription PIC biosynthesis|RNA polymerase II transcriptional preinitiation complex formation|RNA polymerase II transcriptional preinitiation complex assembly|RNA polymerase II transcription PIC formation biological_process owl:Class
GO:0006367 biolink:NamedThing transcription initiation from RNA polymerase II promoter Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. got7fsn_ti transcription initiation from Pol II promoter Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. biological_process owl:Class
GO:0003777 biolink:NamedThing microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. got7fsn_ti kinesin motor activity|dynein ATPase activity|kinesin|dynein|kinetochore motor activity|axonemal motor activity|ATP-dependent microtubule motor activity https://github.com/geneontology/go-ontology/issues/18664 Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. vw 2016-04-04T10:59:42Z GO:1990939 Reactome:R-HSA-265160|Reactome:R-HSA-9610627|Reactome:R-HSA-177479 molecular_function owl:Class
GO:0001534 biolink:NamedThing radial spoke Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules. got7fsn_ti Wikipedia:Radial_spoke cellular_component owl:Class
GO:0002494 biolink:NamedThing lipid antigen transport The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0007403 biolink:NamedThing glial cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti GO:0043361 biological_process owl:Class
GO:1902868 biolink:NamedThing positive regulation of retina development in camera-type eye Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye. got7fsn_ti up regulation of retinal development|activation of retina development in camera-type eye|positive regulation of retinal development|upregulation of retina development in camera-style eye|up-regulation of retina development in camera-type eye|up-regulation of retinal development|activation of retinal development|activation of retina development in camera-style eye|positive regulation of retina development in camera-style eye|upregulation of retina development in camera-type eye|up-regulation of retina development in camera-style eye|up regulation of retina development in camera-style eye|upregulation of retinal development|up regulation of retina development in camera-type eye mr 2014-04-03T15:24:29Z biological_process owl:Class
GO:0002919 biolink:NamedThing positive regulation of peripheral B cell anergy Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy. got7fsn_ti up-regulation of peripheral B cell anergy|upregulation of peripheral B cell anergy|activation of peripheral B cell anergy|up regulation of peripheral B cell anergy|stimulation of peripheral B cell anergy biological_process owl:Class
GO:0036310 biolink:NamedThing ATP-dependent DNA/DNA annealing activity An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule. got7fsn_ti ATP-dependent DNA annealing activity|annealing helicase activity|nucleoside-triphosphatase activity involved in DNA annealing|DNA rewinding activity https://github.com/geneontology/go-ontology/issues/19669|https://github.com/geneontology/go-ontology/issues/9815|https://github.com/geneontology/go-ontology/issues/12465 bf 2012-08-14T15:24:29Z Reactome:R-HSA-5686642 molecular_function owl:Class
GO:0042471 biolink:NamedThing ear morphogenesis The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. got7fsn_ti hearing organ morphogenesis biological_process owl:Class
GO:0048701 biolink:NamedThing embryonic cranial skeleton morphogenesis The process in which the anatomical structures of the cranial skeleton are generated and organized during the embryonic phase. got7fsn_ti embryonic cranium morphogenesis biological_process owl:Class
GO:0001841 biolink:NamedThing neural tube formation The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. got7fsn_ti neural tube morphogenesis|neurulation GO:0001679 Wikipedia:Neurulation biological_process owl:Class
GO:0021578 biolink:NamedThing hindbrain maturation A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. got7fsn_ti biological_process owl:Class
GO:0106165 biolink:NamedThing negative regulation of exonucleolytic catabolism of deadenylated mRNA Any process that stops, prevents, or reduces the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. got7fsn_ti hjd 2019-01-15T15:42:13Z biological_process owl:Class
GO:0000288 biolink:NamedThing nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability. got7fsn_ti mRNA catabolic process, deadenylylation-dependent|mRNA degradation, deadenylation-dependent decay|mRNA catabolism, deadenylylation-dependent|deadenylation-dependent mRNA decay|mRNA catabolic process, deadenylation-dependent|nuclear mRNA catabolic process, deadenylation-dependent decay|mRNA catabolism, deadenylation-dependent|mRNA breakdown, deadenylation-dependent decay https://github.com/geneontology/go-ontology/issues/20568 biological_process owl:Class
GO:0010235 biolink:NamedThing guard mother cell cytokinesis The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells. got7fsn_ti guard mother cell division biological_process owl:Class
GO:0031430 biolink:NamedThing M band The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines. got7fsn_ti midline|mesophragma|M disc|M line Wikipedia:Sarcomere#bands cellular_component owl:Class
GO:0098009 biolink:NamedThing viral terminase, large subunit The part of the viral terminase complex that contains the translocase and endonuclease activities and allows the translocation of the phage DNA into the procapsid. The large subunit usually assembles as a heterooligomer with the small subunit. got7fsn_ti virus terminase, large subunit This term should only be used when the large subunit consists of more than one polypeptide. bm 2012-07-25T10:13:00Z cellular_component owl:Class
GO:0019093 biolink:NamedThing mitochondrial RNA localization Any process in which mitochondrial RNA is transported to, or maintained in, a specific location. got7fsn_ti mtRNA localization|mitochondrial RNA localisation|establishment and maintenance of mitochondrial RNA localization biological_process owl:Class
GO:0038057 biolink:NamedThing TNFSF11 binding Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family. got7fsn_ti RANKL binding|receptor activator of nuclear factor kappa-B ligand binding|TRANCE binding|tumor necrosis factor ligand superfamily member 11 binding|osteoprotegerin ligand binding|OPGL binding|osteoclast differentiation factor binding|tumor necrosis factor (ligand) superfamily member 11 binding|CD254 binding|tumor necrosis factor superfamily member 11 binding|ODF binding|TNF-related activation-induced cytokine binding bf 2012-01-04T03:25:59Z molecular_function owl:Class
GO:1990260 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter using a mechanism that involves the localization of a transcription factor and initiated in response to the DNA damage checkpoint signaling. got7fsn_ti al 2014-01-07T17:10:11Z biological_process owl:Class
GO:0042699 biolink:NamedThing follicle-stimulating hormone signaling pathway The series of molecular signals mediated by follicle-stimulating hormone. got7fsn_ti follicle-stimulating hormone signalling pathway|follicle stimulating hormone signalling pathway|follicle stimulating hormone signaling pathway biological_process owl:Class
GO:0001541 biolink:NamedThing ovarian follicle development The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. got7fsn_ti follicular phase biological_process owl:Class
GO:0004918 biolink:NamedThing interleukin-8 receptor activity Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-8 receptor activity|IL-8R molecular_function owl:Class
GO:0038112 biolink:NamedThing interleukin-8-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-8-mediated signalling pathway|IL-8-mediated signaling pathway bf 2012-03-22T10:19:59Z biological_process owl:Class
GO:0097543 biolink:NamedThing ciliary inversin compartment Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium. got7fsn_ti flagellar inversin compartment|flagellum inversin compartment|Inv compartment of the cilium|cilial inversin compartment|cilium inversin compartment|inversin compartment Note that cilia and eukaryotic flagella are deemed to be equivalent. pr 2013-12-12T11:14:36Z cellular_component owl:Class
GO:0060443 biolink:NamedThing mammary gland morphogenesis The process in which anatomical structures of the mammary gland are generated and organized. Morphogenesis refers to the creation of shape. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. got7fsn_ti biological_process owl:Class
GO:2000827 biolink:NamedThing mitochondrial RNA surveillance The set of processes involved in identifying and degrading defective or aberrant RNAs that takes place in the mitochondrion. got7fsn_ti RNA surveillance in mitochondria|aberrant RNA catabolic process in mitochondrion|RNA quality control in mitochondria|RNA quality control in mitochondrion|aberrant RNA catabolic process in mitochondria bf 2011-07-20T01:33:23Z biological_process owl:Class
GO:1904818 biolink:NamedThing visceral peritoneum development The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure. got7fsn_ti dph 2015-11-17T19:00:17Z biological_process owl:Class
GO:1904820 biolink:NamedThing peritoneum development The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure. got7fsn_ti peritonaeum development dph 2015-11-18T17:23:51Z biological_process owl:Class
GO:0052324 biolink:NamedThing plant-type cell wall cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall. got7fsn_ti cell wall cellulose biosynthesis|cellulose biosynthesis during cell wall biosynthesis biological_process owl:Class
GO:0072553 biolink:NamedThing terminal button organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. got7fsn_ti terminal button organisation|synaptic bouton organization|bouton organization|presynaptic bouton organization|terminal bouton organization mah 2011-01-25T04:09:35Z biological_process owl:Class
GO:2000636 biolink:NamedThing positive regulation of primary miRNA processing Any process that activates or increases the frequency, rate or extent of primary microRNA processing. got7fsn_ti positive regulation of pri-miRNA processing|positive regulation of primary microRNA processing dph 2011-04-18T03:50:56Z biological_process owl:Class
GO:0008029 biolink:NamedThing pentraxin receptor activity Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti pentaxin receptor Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). molecular_function owl:Class
GO:0001864 biolink:NamedThing pentraxin binding Binding to a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array. got7fsn_ti Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). molecular_function owl:Class
GO:0015091 biolink:NamedThing ferric iron transmembrane transporter activity Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. got7fsn_ti Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity. molecular_function owl:Class
GO:1904431 biolink:NamedThing positive regulation of t-circle formation Any process that activates or increases the frequency, rate or extent of t-circle formation. got7fsn_ti up-regulation of t-circle formation|positive regulation of telomeric circle formation|activation of t-circle formation|upregulation of t-circle formation|up regulation of telomeric circle formation|upregulation of telomeric circle formation|up-regulation of telomeric circle formation|up regulation of t-circle formation|activation of telomeric circle formation nc 2015-07-03T15:15:58Z biological_process owl:Class
GO:0072112 biolink:NamedThing glomerular visceral epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. got7fsn_ti podocyte differentiation mah 2010-02-22T10:52:11Z biological_process owl:Class
GO:0048091 biolink:NamedThing positive regulation of female pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in females. got7fsn_ti upregulation of female pigmentation|stimulation of female pigmentation|up-regulation of female pigmentation|up regulation of female pigmentation|activation of female pigmentation biological_process owl:Class
GO:2001257 biolink:NamedThing regulation of cation channel activity Any process that modulates the frequency, rate or extent of cation channel activity. got7fsn_ti regulation of nonselective cation channel activity|regulation of cation diffusion facilitator activity vk 2011-12-07T07:14:43Z biological_process owl:Class
GO:0098655 biolink:NamedThing cation transmembrane transport The process in which a cation is transported across a membrane. got7fsn_ti ATP hydrolysis coupled cation transmembrane transport GO:0099132 biological_process owl:Class
GO:0150048 biolink:NamedThing cerebellar granule cell to Purkinje cell synapse A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum. got7fsn_ti cerebellar parallel fiber to Purkinje cell synapse bc 2018-04-23T14:44:40Z cellular_component owl:Class
CL:0000121 biolink:NamedThing got7fsn_ti owl:Class
GO:0060426 biolink:NamedThing lung vasculature development The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs. got7fsn_ti pulmonary vasculature development biological_process owl:Class
GO:0008493 biolink:NamedThing tetracycline transmembrane transporter activity Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). got7fsn_ti tetracycline transporter activity|tetracyclin transporter activity molecular_function owl:Class
GO:0015904 biolink:NamedThing tetracycline transmembrane transport The directed movement of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). got7fsn_ti tetracycline transport|tetracyclin transport biological_process owl:Class
GO:0003149 biolink:NamedThing membranous septum morphogenesis The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. got7fsn_ti tb 2009-09-22T07:51:41Z biological_process owl:Class
GO:0060412 biolink:NamedThing ventricular septum morphogenesis The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another. got7fsn_ti interventricular septum morphogenesis biological_process owl:Class
GO:1903463 biolink:NamedThing regulation of mitotic cell cycle DNA replication Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication. got7fsn_ti regulation of DNA replication involved in S phase involved in mitotic cell cycle|regulation of mitotic nuclear cell cycle DNA replication|regulation of DNA replication involved in S-phase involved in mitotic cell cycle|regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|regulation of DNA replication during S phase involved in mitotic cell cycle vw 2014-09-23T13:38:25Z biological_process owl:Class
GO:0038089 biolink:NamedThing positive regulation of cell migration by vascular endothelial growth factor signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another. got7fsn_ti VEGF-A-induced cell migration|positive regulation of cell migration by vascular endothelial growth factor signalling pathway|VEGF-induced cell migration|positive regulation of cell migration by VEGF signaling pathway bf 2012-02-02T03:40:13Z biological_process owl:Class
GO:0015187 biolink:NamedThing glycine transmembrane transporter activity Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. got7fsn_ti glycine betaine/proline porter activity|proline/glycine/betaine:hydrogen/sodium symporter activity|glycine transporter activity molecular_function owl:Class
GO:0015816 biolink:NamedThing glycine transport The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0070801 biolink:NamedThing positive regulation of conidiophore stalk development Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop. got7fsn_ti mah 2009-07-08T04:11:22Z biological_process owl:Class
GO:2001209 biolink:NamedThing positive regulation of transcription elongation from RNA polymerase I promoter Any process that activates or increases the frequency, rate or extent of transcription elongation from RNA polymerase I promoter. got7fsn_ti positive regulation of RNA elongation from Pol I promoter se 2011-11-11T10:46:41Z biological_process owl:Class
GO:0003036 biolink:NamedThing detection of pH by aortic body chemoreceptor signaling The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body. got7fsn_ti detection of pH by aortic body chemoreceptor signalling biological_process owl:Class
GO:0042908 biolink:NamedThing xenobiotic transport The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti drug transport https://github.com/geneontology/go-ontology/issues/19460 GO:0015893 biological_process owl:Class
GO:0070903 biolink:NamedThing mitochondrial tRNA thio-modification The addition a sulfur atom to a nucleotide in a mitochondrial tRNA molecule. got7fsn_ti mah 2009-09-02T04:11:17Z biological_process owl:Class
GO:0021633 biolink:NamedThing optic nerve structural organization The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. got7fsn_ti optic nerve structural organisation|CN II structural organization biological_process owl:Class
GO:0150047 biolink:NamedThing G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. got7fsn_ti G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential bc 2018-04-23T10:51:20Z molecular_function owl:Class
GO:0046696 biolink:NamedThing lipopolysaccharide receptor complex A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens. got7fsn_ti LPS receptor complex Note that this term should not be used to refer to CD14 alone, but the multiprotein receptor complex that it is part of. cellular_component owl:Class
GO:1904959 biolink:NamedThing regulation of cytochrome-c oxidase activity Any process that modulates the frequency, rate or extent of cytochrome-c oxidase activity. got7fsn_ti regulation of warburg's respiratory enzyme activity|regulation of complex IV (mitochondrial electron transport) activity|regulation of cytochrome c oxidase activity|regulation of cytochrome aa3 activity|regulation of indophenolase|regulation of ferrocytochrome c oxidase|regulation of indophenol oxidase|regulation of NADH cytochrome c oxidase|regulation of cytochrome oxidase activity|regulation of cytochrome a3 activity|regulation of ferrocytochrome-c:oxygen oxidoreductase|regulation of cbb3-type cytochrome c oxidase|regulation of caa3-type cytochrome c oxidase|regulation of aa3-type cytochrome c oxidase|regulation of ba3-type cytochrome c oxidase tb 2016-02-09T22:18:27Z biological_process owl:Class
GO:0045283 biolink:NamedThing fumarate reductase complex A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). got7fsn_ti See also the molecular function term 'succinate dehydrogenase (ubiquinone) activity ; GO:0008177'. cellular_component owl:Class
GO:0002520 biolink:NamedThing immune system development The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process. got7fsn_ti biological_process owl:Class
GO:0003230 biolink:NamedThing cardiac atrium development The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle. got7fsn_ti dph 2009-10-13T11:02:07Z biological_process owl:Class
GO:1905142 biolink:NamedThing positive regulation of apical ectodermal ridge formation Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation. got7fsn_ti positive regulation of apical epidermal ridge formation|up-regulation of crista ectodermalis apicalis formation|upregulation of crista ectodermalis apicalis formation|up regulation of apical epidermal ridge formation|up regulation of apical ectodermal ridge formation|up-regulation of apical epidermal ridge formation|upregulation of AER formation|positive regulation of AER formation|up regulation of AER formation|activation of AER formation|upregulation of apical ectodermal ridge formation|upregulation of apical epidermal ridge formation|positive regulation of crista ectodermalis apicalis formation|up regulation of crista ectodermalis apicalis formation|up-regulation of apical ectodermal ridge formation|up-regulation of AER formation dph 2016-04-13T12:16:57Z biological_process owl:Class
GO:0001745 biolink:NamedThing compound eye morphogenesis The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster. got7fsn_ti insect-type retina morphogenesis biological_process owl:Class
GO:0030398 biolink:NamedThing peroxisomal membrane disassembly The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation. got7fsn_ti peroxisomal membrane catabolism|peroxisomal membrane breakdown|peroxisomal membrane degradation biological_process owl:Class
GO:0030242 biolink:NamedThing autophagy of peroxisome The process in which peroxisomes are delivered to a type of vacuole and degraded in response to changing nutrient conditions. got7fsn_ti peroxisome degradation|pexophagy biological_process owl:Class
GO:1990520 biolink:NamedThing separase-securin complex A protein complex that includes separase (a protease which cleaves cohesin as part of chromosome separation) and securin, a protease inhibitor. Chromosome separation is inhibited until securin is degraded by the Anaphase Promoting Complex (APC). got7fsn_ti Cut1-2 complex vw 2014-10-23T10:34:52Z cellular_component owl:Class
GO:0006930 biolink:NamedThing substrate-dependent cell migration, cell extension The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. got7fsn_ti substrate-bound cell migration, cell extension biological_process owl:Class
GO:0061252 biolink:NamedThing mesonephric glomerular epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular epithelial cell. Mesonephric glomerular epithelial cells are specialized epithelial cells that form part of the mesonephric glomerulus; there are two types, mesonephric glomerular parietal epithelial cells and mesonephric glomerular visceral epithelial cells. got7fsn_ti dph 2010-08-30T01:23:50Z biological_process owl:Class
GO:0034658 biolink:NamedThing isopropylmalate transmembrane transporter activity Enables the transfer of isopropylmalate from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0034659 biolink:NamedThing isopropylmalate transport The directed movement of isopropylmalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1904839 biolink:NamedThing negative regulation of male germ-line stem cell asymmetric division Any process that stops, prevents or reduces the frequency, rate or extent of male germ-line stem cell asymmetric division. got7fsn_ti inhibition of male germ-line stem cell asymmetric division|down regulation of male germ-line stem cell renewal|down regulation of male germ-line stem cell asymmetric division|down-regulation of male germ-line stem cell renewal|downregulation of male germ-line stem cell renewal|downregulation of male germ-line stem cell asymmetric division|inhibition of male germ-line stem cell renewal|negative regulation of male germ-line stem cell renewal|down-regulation of male germ-line stem cell asymmetric division sl 2015-12-05T00:28:39Z biological_process owl:Class
GO:1901041 biolink:NamedThing positive regulation of peptide antigen transport Any process that activates or increases the frequency, rate or extent of peptide antigen transport. got7fsn_ti up regulation of peptide antigen transport|activation of peptide antigen transport|upregulation of peptide antigen transport|up-regulation of peptide antigen transport bf 2012-06-22T04:08:26Z biological_process owl:Class
GO:0000916 biolink:NamedThing actomyosin contractile ring contraction The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle. got7fsn_ti actomyosin contractile ring constriction|cytokinesis, actomyosin ring contraction|contractile ring contraction involved in cell cycle cytokinesis|cytokinesis, contractile ring contraction https://github.com/geneontology/go-ontology/issues/21855 biological_process owl:Class
GO:0061988 biolink:NamedThing karyosome formation The chromosome organization process in which meiotic chromosomes in the germ cell nucleus cluster together to form a compact spherical structure called the karyosome. got7fsn_ti dph 2018-02-15T21:24:08Z biological_process owl:Class
GO:1905791 biolink:NamedThing negative regulation of mechanosensory behavior Any process that stops, prevents or reduces the frequency, rate or extent of mechanosensory behavior. got7fsn_ti down regulation of mechanosensory behaviour|negative regulation of behavioural response to mechanical stimulus|negative regulation of behavioral response to mechanical stimulus|down regulation of mechanosensory behavior|down regulation of behavioural response to mechanical stimulus|downregulation of mechanosensory behaviour|inhibition of behavioural response to mechanical stimulus|down regulation of behavioral response to mechanical stimulus|down-regulation of behavioural response to mechanical stimulus|inhibition of mechanosensory behaviour|negative regulation of mechanosensory behaviour|inhibition of behavioral response to mechanical stimulus|down-regulation of behavioral response to mechanical stimulus|inhibition of mechanosensory behavior|downregulation of behavioural response to mechanical stimulus|down-regulation of mechanosensory behaviour|downregulation of mechanosensory behavior|downregulation of behavioral response to mechanical stimulus|down-regulation of mechanosensory behavior hbye 2017-01-09T15:17:15Z biological_process owl:Class
GO:0050790 biolink:NamedThing regulation of catalytic activity Any process that modulates the activity of an enzyme. got7fsn_ti regulation of enzyme activity|regulation of metalloenzyme activity GO:0048552 biological_process owl:Class
GO:0070520 biolink:NamedThing alpha4-beta1 integrin-CD81 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD81, a member of the tetraspan family. got7fsn_ti ITGA4-ITGB1-CD81 complex cellular_component owl:Class
GO:0090399 biolink:NamedThing replicative senescence A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging. got7fsn_ti tb 2011-01-05T02:32:29Z biological_process owl:Class
GO:1903582 biolink:NamedThing negative regulation of basophil degranulation Any process that stops, prevents or reduces the frequency, rate or extent of basophil degranulation. got7fsn_ti down regulation of basophil degranulation|downregulation of basophil degranulation|down-regulation of basophil degranulation|inhibition of basophil degranulation sl 2014-10-31T17:37:33Z biological_process owl:Class
GO:0043381 biolink:NamedThing negative regulation of memory T cell differentiation Any process that stops, prevents, or reduces the rate of memory T cell differentiation. got7fsn_ti down-regulation of memory T cell differentiation|negative regulation of memory T lymphocyte differentiation|down regulation of memory T cell differentiation|negative regulation of memory T-cell differentiation|downregulation of memory T cell differentiation|negative regulation of memory T cell development|inhibition of memory T cell differentiation|negative regulation of memory T-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0015855 biolink:NamedThing pyrimidine nucleobase transport The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti pyrimidine transmembrane transport|pyrimidine transport|pyrimidine base transport|pyrimidine base transmembrane transport biological_process owl:Class
GO:0021994 biolink:NamedThing progression of neural tube closure The process in which the neural folds are fused extending from the initial closure points. got7fsn_ti biological_process owl:Class
GO:0023027 biolink:NamedThing MHC class I protein binding, via antigen binding groove Binding to a major histocompatibility complex class I molecules via the antigen binding groove. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0014838 biolink:NamedThing myoblast fate specification involved in skeletal muscle regeneration The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0014836 biolink:NamedThing myoblast fate commitment involved in skeletal muscle regeneration The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0032478 biolink:NamedThing heterotetrameric decaprenyl diphosphate synthase complex A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1. got7fsn_ti cellular_component owl:Class
GO:0051026 biolink:NamedThing chiasma assembly The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids. got7fsn_ti biological_process owl:Class
GO:0031568 biolink:NamedThing mitotic G1 cell size control checkpoint signaling A signal transduction process that contributes to a cell size control checkpoint during the G1/S transition of the cell cycle. got7fsn_ti signal transduction involved in mitotic cell cycle G1/S transition size control checkpoint|mitotic G1 cell size control checkpoint|G1 cell size control checkpoint|signal transduction involved in G1 cell size control checkpoint|G1 cell size control checkpoint signalling|mitotic cell cycle G1/S transition size control checkpoint GO:0072450 biological_process owl:Class
GO:0000082 biolink:NamedThing G1/S transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. got7fsn_ti biological_process owl:Class
GO:0001554 biolink:NamedThing luteolysis The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy. got7fsn_ti Wikipedia:Luteolysis biological_process owl:Class
GO:0016494 biolink:NamedThing C-X-C chemokine receptor activity Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. got7fsn_ti molecular_function owl:Class
GO:0031251 biolink:NamedThing PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces. got7fsn_ti poly(A) nuclease complex cellular_component owl:Class
GO:0009426 biolink:NamedThing bacterial-type flagellum basal body, distal rod The portion of the central rod of the bacterial-type flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. got7fsn_ti flagellin-based flagellum basal body, distal rod|flagellar basal body, distal rod cellular_component owl:Class
GO:0097735 biolink:NamedThing DIM/DIP cell wall layer A section of the Actinobacterium-type cell wall composed of (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate, diphthioceranate and other compounds. got7fsn_ti pr 2016-10-05T14:55:30Z cellular_component owl:Class
GO:0048801 biolink:NamedThing antennal joint morphogenesis The process in which the anatomical structures of the antennal joint are generated and organized. got7fsn_ti biological_process owl:Class
GO:0070306 biolink:NamedThing lens fiber cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. got7fsn_ti lens fibre cell differentiation biological_process owl:Class
GO:0002088 biolink:NamedThing lens development in camera-type eye The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. got7fsn_ti lens development|lens development in camera-style eye biological_process owl:Class
GO:0051200 biolink:NamedThing positive regulation of prosthetic group metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group. got7fsn_ti positive regulation of coenzyme and prosthetic group metabolic process|upregulation of prosthetic group metabolic process|positive regulation of prosthetic group metabolism|activation of prosthetic group metabolic process|up regulation of prosthetic group metabolic process|stimulation of prosthetic group metabolic process|positive regulation of coenzyme and prosthetic group metabolism|up-regulation of prosthetic group metabolic process biological_process owl:Class
GO:0001070 biolink:NamedThing RNA-binding transcription regulator activity A transcription regulator activity that modulates the transcription of specific gene sets via selective and non-covalent binding to a specific RNA sequence. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences. got7fsn_ti RNA binding transcription factor activity|RNA binding transcription regulator activity https://github.com/geneontology/go-ontology/issues/14872 krc 2010-10-21T04:19:17Z molecular_function owl:Class
NCBITaxon:10239 biolink:NamedThing got7fsn_ti owl:Class
GO:0071059 biolink:NamedThing alpha6-beta1 integrin-CD151 complex A protein complex that consists of an alpha6-beta1 integrin complex bound to the tetraspanin CD151. got7fsn_ti ITGA6-ITGB1-CD151 complex mah 2009-11-03T04:01:23Z cellular_component owl:Class
GO:0002001 biolink:NamedThing renin secretion into blood stream The regulated release of renin into the blood stream by juxtoglomerular cells. got7fsn_ti renin release into blood stream biological_process owl:Class
GO:0120141 biolink:NamedThing regulation of ecdysone receptor-mediated signaling pathway Any process that modulates the frequency, rate or extent of the activity of any ecdysone receptor-mediated signaling pathway. got7fsn_ti krc 2018-03-22T17:10:29Z biological_process owl:Class
GO:1903800 biolink:NamedThing positive regulation of production of miRNAs involved in gene silencing by miRNA Any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA. got7fsn_ti up regulation of microRNA metabolic process|up-regulation of gene silencing by miRNA, production of miRNAs|activation of production of microRNAs involved in gene silencing by microRNA|activation of microRNA-mediated gene silencing, production of microRNAs|upregulation of microRNA metabolism|up-regulation of microRNA metabolic process|activation of production of miRNAs involved in gene silencing by miRNA|positive regulation of microRNA-mediated gene silencing, production of microRNAs|positive regulation of production of microRNAs involved in gene silencing by microRNA|activation of microRNA metabolism|upregulation of production of microRNAs involved in gene silencing by microRNA|upregulation of miRNA biogenesis|up-regulation of microRNA biosynthetic process|positive regulation of microRNA biosynthetic process|positive regulation of microRNA biosynthesis|activation of gene silencing by miRNA, production of miRNAs|up-regulation of miRNA biogenesis|up regulation of gene silencing by miRNA, production of miRNAs|activation of microRNA biogenesis|upregulation of microRNA biosynthesis|up regulation of microRNA biosynthesis|upregulation of production of miRNAs involved in gene silencing by miRNA|activation of miRNA processing|activation of microRNA biosynthetic process|activation of microRNA metabolic process|positive regulation of miRNA-mediated gene silencing, production of miRNAs|upregulation of microRNA biosynthetic process|up-regulation of microRNA biosynthesis|positive regulation of microRNA metabolic process|up-regulation of microRNA-mediated gene silencing, production of microRNAs|up regulation of miRNA biogenesis|up regulation of microRNA biogenesis|up regulation of production of microRNAs involved in gene silencing by microRNA|upregulation of miRNA processing|upregulation of gene silencing by miRNA, production of miRNAs|upregulation of miRNA-mediated gene silencing, production of miRNAs|upregulation of microRNA biogenesis|positive regulation of miRNA processing|positive regulation of miRNA biogenesis|up-regulation of production of miRNAs involved in gene silencing by miRNA|up regulation of miRNA-mediated gene silencing, production of miRNAs|up-regulation of miRNA-mediated gene silencing, production of miRNAs|up-regulation of microRNA biogenesis|activation of microRNA biosynthesis|activation of miRNA biogenesis|activation of miRNA-mediated gene silencing, production of miRNAs|positive regulation of gene silencing by miRNA, production of miRNAs|up regulation of microRNA-mediated gene silencing, production of microRNAs|up regulation of microRNA metabolism|positive regulation of microRNA metabolism|up regulation of miRNA processing|up-regulation of production of microRNAs involved in gene silencing by microRNA|up-regulation of microRNA metabolism|up regulation of production of miRNAs involved in gene silencing by miRNA|positive regulation of microRNA biogenesis|up regulation of microRNA biosynthetic process|upregulation of microRNA-mediated gene silencing, production of microRNAs|upregulation of microRNA metabolic process|up-regulation of miRNA processing rph 2015-01-15T13:58:31Z biological_process owl:Class
GO:0140545 biolink:NamedThing protein disaggregase activity An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19173 pg 2020-11-10T16:57:19Z molecular_function owl:Class
GO:1901584 biolink:NamedThing tetrapeptide transmembrane transporter activity Enables the transfer of tetrapeptide from one side of a membrane to the other. got7fsn_ti jl 2012-11-06T15:40:10Z molecular_function owl:Class
GO:1901583 biolink:NamedThing tetrapeptide transmembrane transport The directed movement of tetrapeptide across a membrane. got7fsn_ti tetrapeptide membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. jl 2012-11-06T15:40:02Z biological_process owl:Class
GO:0150077 biolink:NamedThing regulation of neuroinflammatory response Any process that modulates the frequency, rate or extent of neuroinflammatory response. got7fsn_ti bc 2018-07-26T12:32:18Z biological_process owl:Class
GO:1901194 biolink:NamedThing negative regulation of formation of translation preinitiation complex Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation preinitiation complex. got7fsn_ti inhibition of formation of translation preinitiation complex|down regulation of formation of translation pre-initiation complex|downregulation of formation of translation pre-initiation complex|down regulation of formation of translation preinitiation complex|down-regulation of translation preinitiation complex assembly|negative regulation of formation of translation pre-initiation complex|down regulation of translation preinitiation complex assembly|negative regulation of translation preinitiation complex assembly|inhibition of formation of translation pre-initiation complex|down-regulation of formation of translation pre-initiation complex|downregulation of formation of translation preinitiation complex|inhibition of translation preinitiation complex assembly|downregulation of translation preinitiation complex assembly|down-regulation of formation of translation preinitiation complex ss 2012-07-25T02:31:41Z biological_process owl:Class
GO:1901393 biolink:NamedThing negative regulation of transforming growth factor beta1 activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta1 activation. got7fsn_ti down regulation of TGFB1 activation|inhibition of latent-TGF-beta1 activation|down-regulation of TGF-beta 1 activation|downregulation of latent-TGF-beta1 activation|down regulation of transforming growth factor-beta1 activation|downregulation of TGFB1 activation|negative regulation of TGFbeta 1 activation|down regulation of latent-TGF-beta1 activation|down-regulation of TGFB1 activation|inhibition of transforming growth factor-beta1 activation|downregulation of L-TGF-beta 1 activation|negative regulation of TGF-beta 1 activation|down-regulation of TGFbeta 1 activation|inhibition of L-TGF-beta 1 activation|down regulation of transforming growth factor beta1 activation|negative regulation of transforming growth factor-beta1 activation|down regulation of TGFbeta 1 activation|inhibition of transforming growth factor beta1 activation|down regulation of TGF-beta 1 activation|downregulation of TGFbeta 1 activation|inhibition of TGFB1 activation|down regulation of L-TGF-beta 1 activation|downregulation of transforming growth factor-beta1 activation|down-regulation of L-TGF-beta 1 activation|negative regulation of TGFB1 activation|negative regulation of L-TGF-beta 1 activation|inhibition of TGF-beta 1 activation|down-regulation of transforming growth factor beta1 activation|inhibition of TGFbeta 1 activation|negative regulation of latent-TGF-beta1 activation|down-regulation of transforming growth factor-beta1 activation|downregulation of transforming growth factor beta1 activation|down-regulation of latent-TGF-beta1 activation|downregulation of TGF-beta 1 activation bf 2012-10-01T10:41:17Z biological_process owl:Class
GO:0060888 biolink:NamedThing limb epidermis stratification The pattern specification process that results in the subdivision of the epidermis of the limb in space to define a volume in which specific patterns of basal cell, spinous cell and granular cells will differentiate giving rise to the layers of the limb epidermis. got7fsn_ti dph 2009-08-13T12:45:48Z biological_process owl:Class
GO:0035044 biolink:NamedThing sperm aster formation Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei. got7fsn_ti biological_process owl:Class
GO:0097567 biolink:NamedThing right tetrad Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the right lateral basal body pair and the right middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally). got7fsn_ti Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T16:32:33Z cellular_component owl:Class
GO:2001118 biolink:NamedThing tetrahydromethanopterin biosynthetic process The chemical reactions and pathways resulting in the formation of a tetrahydromethanopterin. got7fsn_ti tetrahydromethanopterin biosynthesis jl 2011-10-11T12:13:19Z biological_process owl:Class
GO:0070527 biolink:NamedThing platelet aggregation The adhesion of one platelet to one or more other platelets via adhesion molecules. got7fsn_ti thrombocyte aggregation|blood platelet aggregation biological_process owl:Class
GO:0032255 biolink:NamedThing maintenance of secretory granule location Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of secretory granule localization biological_process owl:Class
GO:0032252 biolink:NamedThing secretory granule localization Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti secretory granule localisation|secretory granule clustering biological_process owl:Class
GO:0021685 biolink:NamedThing cerebellar granular layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. got7fsn_ti cerebellar granular layer structural organisation biological_process owl:Class
GO:0021698 biolink:NamedThing cerebellar cortex structural organization The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. got7fsn_ti cerebellar cortex structural organisation biological_process owl:Class
GO:1990529 biolink:NamedThing glycosylphosphatidylinositol-mannosyltransferase I complex A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M. got7fsn_ti GPI-MT-I complex rb 2014-11-06T01:02:31Z cellular_component owl:Class
GO:0009832 biolink:NamedThing plant-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana. got7fsn_ti cell wall assembly|cell wall biosynthetic process|cell wall synthesis|cell wall anabolism|cell wall formation|cellulose and pectin-containing cell wall biogenesis biological_process owl:Class
GO:0021560 biolink:NamedThing abducens nerve development The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. got7fsn_ti cranial nerve VI development|cranial nerve 6 development|CN VI development biological_process owl:Class
GO:0035813 biolink:NamedThing regulation of renal sodium excretion Any process that modulates the amount of sodium excreted in urine over a unit of time. got7fsn_ti bf 2011-04-20T01:26:30Z biological_process owl:Class
OBO:OBA_0000001 biolink:NamedThing got7fsn_ti owl:Class
GO:0070901 biolink:NamedThing mitochondrial tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule. got7fsn_ti mah 2009-09-02T04:08:00Z biological_process owl:Class
GO:1905222 biolink:NamedThing atrioventricular canal morphogenesis The developmental process by which an atrioventricular canal is generated and organized. got7fsn_ti ependymal canal morphogenesis|AVC morphogenesis|atrial canal morphogenesis|canalis atrioventricularis morphogenesis|AV canal morphogenesis|atrio-ventricular canal morphogenesis rl 2016-06-07T09:09:51Z biological_process owl:Class
GO:0042897 biolink:NamedThing polymyxin transmembrane transporter activity Enables the transfer of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, from one side of a membrane to the other. got7fsn_ti polymyxin transporter activity molecular_function owl:Class
GO:0042893 biolink:NamedThing polymyxin transport The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0032835 biolink:NamedThing glomerulus development The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment. got7fsn_ti glomerular development biological_process owl:Class
GO:1902429 biolink:NamedThing positive regulation of water channel activity Any process that activates or increases the frequency, rate or extent of water channel activity. got7fsn_ti up-regulation of water channel activity|upregulation of aquaporin|positive regulation of aquaporin|upregulation of water channel activity|activation of water channel activity|up-regulation of aquaporin|up regulation of water channel activity|aquaporin activation|activation of aquaporin|up regulation of aquaporin bf 2013-09-23T12:56:49Z biological_process owl:Class
GO:0007620 biolink:NamedThing copulation The act of sexual union between male and female, involving the transfer of sperm. got7fsn_ti biological_process owl:Class
GO:0040036 biolink:NamedThing regulation of fibroblast growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. got7fsn_ti regulation of FGFR signaling pathway|regulation of FGF receptor signaling pathway|regulation of FGF receptor signalling pathway biological_process owl:Class
GO:1903396 biolink:NamedThing negative regulation of secondary cell septum biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of secondary cell septum biogenesis. got7fsn_ti down regulation of secondary cell septum biogenesis|inhibition of secondary cell septum biogenesis|downregulation of secondary cell septum biogenesis|down-regulation of secondary cell septum biogenesis di 2014-08-29T21:42:26Z biological_process owl:Class
GO:0032328 biolink:NamedThing alanine transport The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1904819 biolink:NamedThing parietal peritoneum development The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure. got7fsn_ti peritoneal cavity lining development dph 2015-11-17T19:00:24Z biological_process owl:Class
GO:0070134 biolink:NamedThing positive regulation of mitochondrial translational initiation Any process that activates or increases the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. got7fsn_ti positive regulation of mitochondrial translation initiation biological_process owl:Class
GO:0072306 biolink:NamedThing positive regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. got7fsn_ti positive regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis|positive regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis mah 2010-04-09T05:03:41Z biological_process owl:Class
GO:0072309 biolink:NamedThing mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis The process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti mah 2010-04-09T05:03:41Z biological_process owl:Class
GO:0004363 biolink:NamedThing glutathione synthase activity Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate. got7fsn_ti gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)|glutathione synthetase activity|GSH synthetase activity KEGG_REACTION:R00497|EC:6.3.2.3|Reactome:R-HSA-174394|Reactome:R-HSA-5602901|MetaCyc:GLUTATHIONE-SYN-RXN|RHEA:13557 molecular_function owl:Class
GO:0006750 biolink:NamedThing glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. got7fsn_ti glutathione biosynthesis|glutathione formation|glutathione anabolism|glutathione synthesis MetaCyc:GLUTATHIONESYN-PWY biological_process owl:Class
GO:0014037 biolink:NamedThing Schwann cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. got7fsn_ti biological_process owl:Class
GO:0002553 biolink:NamedThing histamine secretion by mast cell The regulated release of histamine by a mast cell or group of mast cells. got7fsn_ti biological_process owl:Class
GO:1903636 biolink:NamedThing regulation of protein insertion into mitochondrial outer membrane Any process that modulates the frequency, rate or extent of protein insertion into mitochondrial outer membrane. got7fsn_ti regulation of protein transport into mitochondrial outer membrane|regulation of protein import into mitochondrial outer membrane|regulation of mitochondrial outer membrane protein import pga 2014-11-20T15:54:44Z biological_process owl:Class
GO:0043225 biolink:NamedThing ATPase-coupled inorganic anion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in). got7fsn_ti anion ABC transporter|ATPase-coupled anion transmembrane transporter activity|anion-transporting ATPase activity|anion transmembrane-transporting ATPase activity|ATP-dependent anion transmembrane transporter activity Reactome:R-HSA-1454916|Reactome:R-HSA-5690340 molecular_function owl:Class
GO:0098656 biolink:NamedThing anion transmembrane transport The process in which an anion is transported across a membrane. got7fsn_ti ATP hydrolysis coupled anion transmembrane transport GO:0099133 biological_process owl:Class
GO:0071083 biolink:NamedThing alphaV-beta3 integrin-CD47-FCER2 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface protein CD47 and the low-affinity immunoglobulin epsilon Fc receptor (FCER2). got7fsn_ti ITGAV-ITGB3-CD447-FCER2 complex mah 2009-11-06T04:44:20Z cellular_component owl:Class
GO:0043856 biolink:NamedThing anti-sigma factor antagonist activity The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity. got7fsn_ti anti-anti-sigma factor activity molecular_function owl:Class
GO:0007556 biolink:NamedThing regulation of juvenile hormone metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone. got7fsn_ti regulation of juvenile hormone metabolism biological_process owl:Class
GO:0006716 biolink:NamedThing juvenile hormone metabolic process The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. got7fsn_ti juvenile hormone metabolism biological_process owl:Class
GO:0043595 biolink:NamedThing endospore cortex A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan. got7fsn_ti cellular_component owl:Class
GO:0001897 biolink:NamedThing cytolysis by symbiont of host cells The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti pathogenesis|cytolysis by organism of host cells biological_process owl:Class
GO:0061525 biolink:NamedThing hindgut development The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut. got7fsn_ti dph 2013-06-14T11:22:21Z biological_process owl:Class
GO:0099125 biolink:NamedThing PAK family kinase-Sog2 complex A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network. got7fsn_ti cellular_component owl:Class
GO:0045314 biolink:NamedThing regulation of compound eye photoreceptor development Any process that modulates the frequency, rate or extent of compound eye photoreceptor development. got7fsn_ti regulation of eye photoreceptor development biological_process owl:Class
GO:0046532 biolink:NamedThing regulation of photoreceptor cell differentiation Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. got7fsn_ti regulation of photoreceptor differentiation GO:0045673 biological_process owl:Class
GO:0075026 biolink:NamedThing regulation of appressorium initiation Any process that modulates the frequency, rate or extent of symbiont appressorium initiation. got7fsn_ti regulation of appressorium initiation on or near host|regulation of initiation of appressorium on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0006393 biolink:NamedThing termination of mitochondrial transcription The process in which the synthesis of an RNA molecule using a mitochondrial DNA template is completed. got7fsn_ti mitochondrial transcription termination|RNA transcription termination from mitochondrial promoter biological_process owl:Class
GO:0042881 biolink:NamedThing D-galactonate transmembrane transporter activity Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042875 biolink:NamedThing D-galactonate transmembrane transport The process in which D-galactonate, the D-enantiomer of galactonate, is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti D-galactonate transport biological_process owl:Class
GO:0072265 biolink:NamedThing metanephric capsule morphogenesis The process in which the anatomical structures of the metanephric capsule are generated and organized. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. got7fsn_ti mah 2010-03-30T02:54:49Z biological_process owl:Class
GO:0060720 biolink:NamedThing spongiotrophoblast cell proliferation The multiplication or reproduction of spongiotrophoblast cells, resulting in the expansion of the population in the spongiotrophoblast layer. got7fsn_ti dph 2009-06-11T09:50:35Z biological_process owl:Class
GO:0090214 biolink:NamedThing spongiotrophoblast layer developmental growth The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state. got7fsn_ti tb 2010-01-08T12:10:44Z biological_process owl:Class
GO:0061553 biolink:NamedThing ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state. got7fsn_ti ganglia maturation dph 2013-07-10T08:45:59Z biological_process owl:Class
GO:1990073 biolink:NamedThing perforation plate A cell wall part that is the part of a wall of a vessel member and bears one or more openings (perforations). got7fsn_ti Part of a vessel member (PO:0002003). May be simple, with one perforation, or multiperforate, with more than one perforation. Perforation plates are usually on the end walls of a cell, but may also be on the side walls. tb 2013-03-29T00:53:28Z cellular_component owl:Class
GO:0048929 biolink:NamedThing efferent axon development in posterior lateral line nerve The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0048918 biolink:NamedThing posterior lateral line nerve development The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus. got7fsn_ti PLLN development|caudal lateral line nerve development GO:0021733 biological_process owl:Class
GO:0060288 biolink:NamedThing formation of a compartment boundary Formation of a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier. got7fsn_ti compartment boundary formation biological_process owl:Class
CHEBI:30089 biolink:NamedThing got7fsn_ti owl:Class
GO:0033007 biolink:NamedThing negative regulation of mast cell activation involved in immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response. got7fsn_ti negative regulation of mast cell activation during immune response biological_process owl:Class
GO:0110157 biolink:NamedThing reelin complex An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain. got7fsn_ti kmv 2019-07-15T15:10:58Z cellular_component owl:Class
GO:0038026 biolink:NamedThing reelin-mediated signaling pathway A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti reelin-mediated signal transduction pathway|reelin-mediated signalling pathway|reeler-mediated signaling pathway bf 2011-08-02T02:06:18Z biological_process owl:Class
GO:0048265 biolink:NamedThing response to pain Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. got7fsn_ti physiological response to pain GO:0048267 biological_process owl:Class
GO:0042472 biolink:NamedThing inner ear morphogenesis The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively. got7fsn_ti biological_process owl:Class
GO:0045830 biolink:NamedThing positive regulation of isotype switching Any process that activates or increases the frequency, rate or extent of isotype switching. got7fsn_ti up-regulation of isotype switching|stimulation of isotype switching|activation of isotype switching|positive regulation of class switch recombination|up regulation of isotype switching|positive regulation of isotype switch recombination|upregulation of isotype switching|positive regulation of class switching biological_process owl:Class
GO:0071808 biolink:NamedThing satellite fibril An axoneme part that is found in the flagella of mammalian sperm and is located in the middle piece between the outer dense fibers (on the concave side of outer dense fibers as seen in cross-section). got7fsn_ti mah 2010-09-03T03:42:14Z cellular_component owl:Class
GO:0051887 biolink:NamedThing regulation of timing of exogen Any process that modulates the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. got7fsn_ti regulation of exogen biological_process owl:Class
GO:0031925 biolink:NamedThing pyridoxal transmembrane transporter activity Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. got7fsn_ti pyridoxal transporter activity molecular_function owl:Class
GO:1903090 biolink:NamedThing pyridoxal transmembrane transport The process in which pyridoxal is transported across a membrane. got7fsn_ti al 2014-06-03T10:41:13Z biological_process owl:Class
GO:0044225 biolink:NamedThing apical pole of neuron Portion of a neuron cell soma closest to the point where the apical dendrite emerges. got7fsn_ti jl 2009-11-13T03:49:14Z NIF_Subcellular:sao1186862860 cellular_component owl:Class
GO:0033579 biolink:NamedThing protein galactosylation in endoplasmic reticulum The addition of a galactose unit to a protein amino acid in the endoplasmic reticulum. got7fsn_ti protein amino acid galactosylation in ER|protein amino acid galactosylation in endoplasmic reticulum biological_process owl:Class
GO:0007049 biolink:NamedThing cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. got7fsn_ti cell-division cycle Wikipedia:Cell_cycle biological_process owl:Class
GO:0017133 biolink:NamedThing mitochondrial electron transfer flavoprotein complex A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system. got7fsn_ti cellular_component owl:Class
GO:0006967 biolink:NamedThing positive regulation of antifungal peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis. got7fsn_ti up-regulation of antifungal peptide biosynthetic process|antifungal polypeptide induction|stimulation of antifungal peptide biosynthetic process|upregulation of antifungal peptide biosynthetic process|activation of antifungal peptide biosynthetic process|antifungal peptide induction|up regulation of antifungal peptide biosynthetic process biological_process owl:Class
GO:0070720 biolink:NamedThing Grb2-SHP-2 complex A protein complex that contains the receptor adaptor proteins Grb2 and SHP-2, and is involved signaling via the PDGFR signaling pathway. got7fsn_ti GRB2-SHP-2 complex, PDGF stimulated mah 2009-06-10T05:08:21Z cellular_component owl:Class
GO:1903401 biolink:NamedThing L-lysine transmembrane transport The directed movement of L-lysine across a membrane. got7fsn_ti pr 2014-09-01T13:45:56Z biological_process owl:Class
GO:0001403 biolink:NamedThing invasive growth in response to glucose limitation A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti colony morphology Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO. biological_process owl:Class
GO:0003162 biolink:NamedThing atrioventricular node development The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system. got7fsn_ti AV node development dph 2009-10-01T02:05:13Z biological_process owl:Class
NCBITaxon:Union_0000007 biolink:NamedThing got7fsn_ti owl:Class
GO:0055051 biolink:NamedThing ATP-binding cassette (ABC) transporter complex, integrated substrate binding A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a half transporter. Two half-transporters come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. got7fsn_ti cellular_component owl:Class
GO:0042329 biolink:NamedThing structural constituent of collagen and cuticulin-based cuticle The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans. got7fsn_ti structural constituent of cuticle molecular_function owl:Class
GO:0030715 biolink:NamedThing oocyte growth in germarium-derived egg chamber The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0060342 biolink:NamedThing photoreceptor inner segment membrane The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. got7fsn_ti cellular_component owl:Class
GO:0007127 biolink:NamedThing meiosis I The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei. got7fsn_ti meiosis I nuclear division Wikipedia:Meiosis#Meiosis_I biological_process owl:Class
GO:0031514 biolink:NamedThing motile cilium A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell. got7fsn_ti motile primary cilium|motile cilia|nodal cilium|motile primary cilia|motile secondary cilium|microtubule-based flagellum GO:0031512|GO:0009434 cellular_component owl:Class
GO:0015605 biolink:NamedThing organophosphate ester transmembrane transporter activity Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. got7fsn_ti molecular_function owl:Class
GO:0015748 biolink:NamedThing organophosphate ester transport The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds. got7fsn_ti biological_process owl:Class
GO:0045328 biolink:NamedThing cytochrome P450 4A1-heme linkage The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester. got7fsn_ti cytochrome P450 4A1-haem linkage RESID:AA0324 biological_process owl:Class
GO:0072211 biolink:NamedThing metanephric pyramids development The process whose specific outcome is the progression of the metanephric pyramids over time, from their formation to the mature structures. Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts. got7fsn_ti metanephric renal medulla development|metanephric renal pyramid development|metanephric pyramid development|metanephric kidney pyramid development mah 2010-03-18T01:04:51Z biological_process owl:Class
GO:0061797 biolink:NamedThing pH-gated chloride channel activity A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH. got7fsn_ti dph 2016-10-06T07:11:14Z molecular_function owl:Class
GO:0035076 biolink:NamedThing ecdysone receptor-mediated signaling pathway The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex. got7fsn_ti ecdysone receptor-mediated signalling pathway biological_process owl:Class
GO:0015012 biolink:NamedThing heparan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. got7fsn_ti heparan sulfate proteoglycan formation|heparan sulphate proteoglycan biosynthesis|heparin proteoglycan biosynthetic process|heparan sulfate proteoglycan anabolism|heparan sulfate proteoglycan biosynthesis|heparan sulphate proteoglycan biosynthetic process|heparan sulfate proteoglycan synthesis RESID:AA0210 biological_process owl:Class
GO:0007351 biolink:NamedThing tripartite regional subdivision Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions. got7fsn_ti biological_process owl:Class
GO:1903595 biolink:NamedThing positive regulation of histamine secretion by mast cell Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell. got7fsn_ti up-regulation of histamine secretion by mast cell|upregulation of histamine secretion by mast cell|activation of histamine secretion by mast cell|up regulation of histamine secretion by mast cell als 2014-11-06T13:19:26Z biological_process owl:Class
GO:0060281 biolink:NamedThing regulation of oocyte development Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0043485 biolink:NamedThing endosome to pigment granule transport The directed movement of substances from endosomes to pigment granules. got7fsn_ti biological_process owl:Class
GO:0051299 biolink:NamedThing centrosome separation The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. got7fsn_ti biological_process owl:Class
GO:0150104 biolink:NamedThing transport across blood-brain barrier The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. got7fsn_ti transport across blood brain barrier|transport across BBB bc 2019-05-27T09:12:03Z biological_process owl:Class
GO:0070039 biolink:NamedThing rRNA (guanosine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylguanosine. got7fsn_ti Reactome:R-HSA-6793096|Reactome:R-HSA-6793122 molecular_function owl:Class
GO:0005825 biolink:NamedThing half bridge of spindle pole body Structure adjacent to the plaques of the spindle pole body. got7fsn_ti cellular_component owl:Class
GO:0035881 biolink:NamedThing amacrine cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons. got7fsn_ti amacrine neuron differentiation bf 2011-06-06T11:32:50Z biological_process owl:Class
GO:0017090 biolink:NamedThing meprin A complex A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues. got7fsn_ti PABA peptide hydrolase complex cellular_component owl:Class
GO:0015649 biolink:NamedThing 2-keto-3-deoxygluconate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in). got7fsn_ti 2-keto-3-deoxygluconate:hydrogen symporter activity molecular_function owl:Class
GO:0046411 biolink:NamedThing 2-keto-3-deoxygluconate transmembrane transport The process in which 2-keto-3-deoxygluconate is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti 2-keto-3-deoxygluconate transport biological_process owl:Class
GO:1990720 biolink:NamedThing C2 axonemal microtubule One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections. got7fsn_ti C2 tubule krc 2015-03-27T22:58:40Z cellular_component owl:Class
GO:0009862 biolink:NamedThing systemic acquired resistance, salicylic acid mediated signaling pathway The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance. got7fsn_ti systemic acquired resistance, salicylic acid mediated signalling pathway|salicylic acid mediated signaling pathway (systemic acquired resistance) biological_process owl:Class
GO:0060241 biolink:NamedThing lysozyme inhibitor activity Binds to and stops, prevents or reduces the activity of lysozyme. got7fsn_ti molecular_function owl:Class
GO:0015884 biolink:NamedThing folic acid transport The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. got7fsn_ti folate transport|vitamin M transport|vitamin B9 transport biological_process owl:Class
GO:0060511 biolink:NamedThing creation of an inductive signal by a mesenchymal cell involved in lung induction The process in which splanchnic mesenchymal cells send a signal over a short range to endodermal cells inducing them to form the primary lung bud. got7fsn_ti biological_process owl:Class
GO:0046858 biolink:NamedThing chlorosome A large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate. got7fsn_ti Wikipedia:Chlorosome cellular_component owl:Class
GO:0035858 biolink:NamedThing eosinophil fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti eosinophil cell fate determination bf 2011-05-17T10:43:35Z biological_process owl:Class
GO:1902939 biolink:NamedThing negative regulation of intracellular calcium activated chloride channel activity Any process that stops, prevents or reduces the frequency, rate or extent of intracellular calcium activated chloride channel activity. got7fsn_ti down regulation of intracellular calcium activated chloride channel activity|down-regulation of intracellular calcium activated chloride channel activity|downregulation of intracellular calcium activated chloride channel activity|inhibition of intracellular calcium activated chloride channel activity als 2014-04-28T08:49:14Z biological_process owl:Class
GO:1990916 biolink:NamedThing Isp3 layer of spore wall The outermost layers of the spore wall, as described in Schizosaccharomyces pombe. got7fsn_ti al 2015-12-09T19:07:23Z cellular_component owl:Class
GO:0021670 biolink:NamedThing lateral ventricle development The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle. got7fsn_ti biological_process owl:Class
GO:0021591 biolink:NamedThing ventricular system development The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus. got7fsn_ti biological_process owl:Class
GO:0032435 biolink:NamedThing negative regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. got7fsn_ti down regulation of proteasomal ubiquitin-dependent protein catabolic process|inhibition of proteasomal ubiquitin-dependent protein catabolic process|downregulation of proteasomal ubiquitin-dependent protein catabolic process|down-regulation of proteasomal ubiquitin-dependent protein catabolic process biological_process owl:Class
GO:0009554 biolink:NamedThing megasporogenesis The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus. got7fsn_ti megaspore mother cell meiosis|megaspore development|meiosis of the megasporocyte|meiotic division of the megasporocyte biological_process owl:Class
GO:0000073 biolink:NamedThing initial mitotic spindle pole body separation The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules that elongate from each pole are interconnected, forming overlapping microtubules. Capturing and antiparallel sliding apart of microtubules promotes the initial separation of the SPB. got7fsn_ti GO:0030475 biological_process owl:Class
GO:1905047 biolink:NamedThing mitotic spindle pole body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitotic spindle pole body. got7fsn_ti vw 2016-03-14T09:48:42Z biological_process owl:Class
GO:0070830 biolink:NamedThing bicellular tight junction assembly The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. got7fsn_ti tight junction formation mah 2009-07-23T04:32:38Z biological_process owl:Class
GO:0001618 biolink:NamedThing virus receptor activity Combining with a virus component and mediating entry of the virus into the cell. got7fsn_ti viral receptor activity molecular_function owl:Class
GO:0046718 biolink:NamedThing viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. got7fsn_ti virion penetration into host cell|virion penetration|virus entry into host cell|viral penetration|phage translocation|entry of virus into host cell Viral attachment to the host cell is not part of viral entry in GO because virus attachment does not always lead to viral entry: attachment can also result in the virion being carried by the host cell to another location. GO:0019063 VZ:936 biological_process owl:Class
GO:2001285 biolink:NamedThing negative regulation of BMP secretion Any process that stops, prevents or reduces the frequency, rate or extent of BMP secretion. got7fsn_ti negative regulation of BMP protein secretion|negative regulation of bone morphogenetic protein secretion bf 2011-12-15T02:15:36Z biological_process owl:Class
GO:0009897 biolink:NamedThing external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. got7fsn_ti juxtamembrane|outer surface of cytoplasmic membrane|external leaflet of plasma membrane cellular_component owl:Class
GO:0071563 biolink:NamedThing Myo2p-Vac17p-Vac8p transport complex A protein complex that is involved in transport of vacuoles to a newly formed daughter cell. In yeast, this complex is composed of Myo2p, Vac17p, and Vac8p. got7fsn_ti mah 2010-01-20T03:03:24Z cellular_component owl:Class
GO:0021577 biolink:NamedThing hindbrain structural organization The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions. got7fsn_ti hindbrain structural organisation biological_process owl:Class
GO:0048908 biolink:NamedThing anterior lateral line ganglion neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion. got7fsn_ti biological_process owl:Class
GO:0010339 biolink:NamedThing external side of cell wall The side of the cell wall that is opposite to the side that faces the cell and its contents. got7fsn_ti cellular_component owl:Class
GO:1901388 biolink:NamedThing regulation of transforming growth factor beta activation Any process that modulates the frequency, rate or extent of transforming growth factor beta activation. got7fsn_ti regulation of latent TGF-beta activation|regulation of TGFbeta activation|regulation of TGFB activation|regulation of L-TGF-beta activation|regulation of TGF-beta activation|regulation of TGF-B activation bf 2012-10-01T10:32:00Z biological_process owl:Class
GO:0071604 biolink:NamedThing transforming growth factor beta production The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3. got7fsn_ti transforming growth factor-beta secretion|transforming growth factor-beta production|TGF-B production|TGF-beta production|TGFb production|TGFbeta production mah 2010-02-05T03:56:57Z GO:0038044 biological_process owl:Class
GO:0031600 biolink:NamedThing cytosolic proteasome regulatory particle A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex. got7fsn_ti cellular_component owl:Class
GO:0061214 biolink:NamedThing mesonephric smooth muscle tissue development The process whose specific outcome is the progression of smooth muscle in the mesonephros over time, from its formation to the mature structure. got7fsn_ti dph 2010-08-17T03:29:54Z biological_process owl:Class
GO:0051417 biolink:NamedThing microtubule nucleation by spindle pole body The 'de novo' formation of a microtubule, mediated by the spindle pole body. got7fsn_ti microtubule nucleation by SPB|SPB-mediated microtubule nucleation|spindle pole body-mediated microtubule nucleation biological_process owl:Class
GO:0007392 biolink:NamedThing initiation of dorsal closure Events that occur at the start of dorsal closure. got7fsn_ti biological_process owl:Class
GO:0007093 biolink:NamedThing mitotic cell cycle checkpoint signaling A signaling process that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage. got7fsn_ti signal transduction involved in mitotic cell cycle checkpoint|signal transduction involved in mitotic cell cycle G1/S checkpoint|signal transduction involved in mitotic G2/M transition checkpoint|mitotic checkpoint|mitotic cell cycle checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0031575|GO:0071780|GO:0072413|GO:0072456|GO:0072474 biological_process owl:Class
GO:0048935 biolink:NamedThing peripheral nervous system neuron development The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron. got7fsn_ti biological_process owl:Class
GO:0005704 biolink:NamedThing polytene chromosome band A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band. got7fsn_ti cellular_component owl:Class
GO:0005700 biolink:NamedThing polytene chromosome A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible. got7fsn_ti Wikipedia:Polytene_chromosome cellular_component owl:Class
GO:0039703 biolink:NamedThing RNA replication The cellular metabolic process in which a cell duplicates one or more molecules of RNA. got7fsn_ti bf 2013-11-21T16:53:29Z biological_process owl:Class
GO:0015277 biolink:NamedThing kainate selective glutamate receptor activity An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. got7fsn_ti Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. molecular_function owl:Class
CHEBI:29101 biolink:NamedThing got7fsn_ti owl:Class
GO:0090654 biolink:NamedThing basolateral recycling endosome Tubulo-vesicular structure located in the basolateral cytoplasm that participates in basolateral cargo recycling in polarized epithelial cells. got7fsn_ti tb 2015-07-01T15:46:19Z cellular_component owl:Class
GO:0110084 biolink:NamedThing negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly. got7fsn_ti kmv 2018-02-01T19:33:51Z biological_process owl:Class
GO:1903475 biolink:NamedThing mitotic actomyosin contractile ring assembly Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis. got7fsn_ti actomyosin contractile ring assembly involved in cytokinesis after mitosis|contractile ring assembly involved in mitotic cytokinesis|cytokinesis, actomyosin contractile ring assembly involved in mitotic cytokinesis vw 2014-09-23T14:42:12Z biological_process owl:Class
GO:0003194 biolink:NamedThing sinoatrial valve formation The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti SA valve formation dph 2009-10-08T01:12:45Z biological_process owl:Class
GO:0003185 biolink:NamedThing sinoatrial valve morphogenesis The process in which the structure of the sinoatrial valve is generated and organized. got7fsn_ti SA valve morphogenesis dph 2009-10-08T12:04:52Z biological_process owl:Class
GO:0042900 biolink:NamedThing arabinose transmembrane transporter activity Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015751 biolink:NamedThing arabinose transmembrane transport The process in which arabinose, a pentose monosaccharide that occurs in both D and L configurations, is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti arabinose transport biological_process owl:Class
GO:0005744 biolink:NamedThing TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. got7fsn_ti mitochondrial inner membrane presequence translocase complex|Tim23 complex|mitochondrial inner membrane pre-sequence translocase complex|mitochondrial inner membrane translocase complex See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. cellular_component owl:Class
GO:0044156 biolink:NamedThing host cell junction A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. got7fsn_ti jl 2009-08-11T04:04:50Z cellular_component owl:Class
GO:0020002 biolink:NamedThing host cell plasma membrane The plasma membrane surrounding a host cell. got7fsn_ti cellular_component owl:Class
GO:0098828 biolink:NamedThing modulation of inhibitory postsynaptic potential Any process that modulates the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. got7fsn_ti regulation of inhibitory postsynaptic potential biological_process owl:Class
GO:1903389 biolink:NamedThing negative regulation of synaptic vesicle uncoating Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle uncoating. got7fsn_ti down regulation of synaptic vesicle coat depolymerization|downregulation of synaptic vesicle coat protein depolymerization|down regulation of synaptic vesicle uncoating|negative regulation of synaptic vesicle coat depolymerization|negative regulation of synaptic vesicle coat protein depolymerization|downregulation of synaptic vesicle uncoating|down-regulation of synaptic vesicle coat depolymerization|down-regulation of synaptic vesicle coat protein depolymerization|down-regulation of synaptic vesicle uncoating|inhibition of synaptic vesicle coat depolymerization|downregulation of synaptic vesicle coat depolymerization|inhibition of synaptic vesicle uncoating|inhibition of synaptic vesicle coat protein depolymerization|down regulation of synaptic vesicle coat protein depolymerization pad 2014-08-27T10:03:02Z biological_process owl:Class
GO:0035670 biolink:NamedThing plant-type ovary development The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed. got7fsn_ti bf 2011-02-04T09:35:05Z biological_process owl:Class
GO:0048440 biolink:NamedThing carpel development The process whose specific outcome is the progression of the carpel over time, from its formation to the mature structure. A carpel is an organ (generally believed to be a modified foliar unit) at the centre of a flower, bearing one or more ovules and having its margins fused together or with other carpels to enclose the ovule in an ovary, and consisting also of a stigma and usually a style. got7fsn_ti GO:0048429 biological_process owl:Class
GO:0030552 biolink:NamedThing cAMP binding Binding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). got7fsn_ti 3',5' cAMP binding|adenosine 3',5'-cyclophosphate binding|3',5'-cAMP binding|cyclic AMP binding molecular_function owl:Class
GO:0015085 biolink:NamedThing calcium ion transmembrane transporter activity Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. got7fsn_ti Reactome:R-HSA-2534359 molecular_function owl:Class
GO:0071714 biolink:NamedThing icosanoid transmembrane transporter activity Enables the transfer of icosanoids from one side of a membrane to the other. got7fsn_ti eicosanoid transmembrane transporter activity mah 2010-03-10T01:50:08Z molecular_function owl:Class
GO:0071715 biolink:NamedThing icosanoid transport The directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds. got7fsn_ti eicosanoid transport mah 2010-03-10T02:47:22Z biological_process owl:Class
GO:1904693 biolink:NamedThing midbrain morphogenesis The developmental process by which a midbrain is generated and organized. got7fsn_ti MB morphogenesis|mesencephalon morphogenesis bf 2015-09-29T09:15:28Z biological_process owl:Class
GO:0007249 biolink:NamedThing I-kappaB kinase/NF-kappaB signaling The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. got7fsn_ti I-kappaB kinase/NF-kappaB cascade|canonical NF-kappaB signaling cascade|NF-kappaB cascade|p50-dependent NF-kappaB signaling|I-kappaB kinase/NF-kappaB signal transduction|activation of the inhibitor of kappa kinase biological_process owl:Class
GO:0030082 biolink:NamedThing B800-850 antenna complex Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex. got7fsn_ti light harvesting complex II|LH2 complex cellular_component owl:Class
GO:0009577 biolink:NamedThing elaioplast stroma The space enclosed by the double membrane of an elaioplast. got7fsn_ti cellular_component owl:Class
GO:0048158 biolink:NamedThing oogonium stage The stage in mammalian oogenesis when the primordial germ cell is hardly distinguishable from other cortical cells of the ovary. got7fsn_ti mammalian oogenesis stage 1 biological_process owl:Class
GO:0106074 biolink:NamedThing aminoacyl-tRNA metabolism involved in translational fidelity Any process which detects an amino-acid acetylated tRNA is charged with the correct amino acid, or removes incorrect amino acids from a charged tRNA. This process can be performed by tRNA synthases, or by subsequent reactions after tRNA aminoacylation. got7fsn_ti aminoacyl-tRNA editin|aminoacyl-tRNA proofreading|aminoacyl-tRNA correction hjd 2017-11-29T17:48:39Z biological_process owl:Class
GO:0050803 biolink:NamedThing regulation of synapse structure or activity Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). got7fsn_ti biological_process owl:Class
GO:1905692 biolink:NamedThing endoplasmic reticulum disassembly The disaggregation of an endoplasmic reticulum into its constituent components. got7fsn_ti ER disassembly pr 2016-11-14T13:39:14Z biological_process owl:Class
GO:2001259 biolink:NamedThing positive regulation of cation channel activity Any process that activates or increases the frequency, rate or extent of cation channel activity. got7fsn_ti positive regulation of cation diffusion facilitator activity|positive regulation of nonselective cation channel activity vk 2011-12-07T07:14:57Z biological_process owl:Class
GO:0021588 biolink:NamedThing cerebellum formation The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. got7fsn_ti biological_process owl:Class
GO:2000803 biolink:NamedThing endosomal signal transduction The process in which a signal is passed on to downstream components located at the endosome. Endosomes can provide important intracellular signaling platforms and provide spatial and temporal control over signal transduction. got7fsn_ti signalling cascade in endosome|signaling pathway in endosome|signaling from endosome|endosome-based signaling|signalling pathway in endosome|signaling cascade in endosome bf 2011-07-01T03:45:12Z biological_process owl:Class
GO:0033367 biolink:NamedThing protein localization to mast cell secretory granule A process in which a protein is transported to, or maintained in, a location within a secretory granule in a mast cell. got7fsn_ti protein localisation in mast cell secretory granule|protein localization in mast cell secretory granule biological_process owl:Class
GO:0071065 biolink:NamedThing alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular cell adhesion molecule-1. got7fsn_ti ITGA9-ITGB1-VCAM1 complex mah 2009-11-03T04:04:01Z cellular_component owl:Class
GO:0005457 biolink:NamedThing GDP-fucose transmembrane transporter activity Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. got7fsn_ti Reactome:R-HSA-5653596|Reactome:R-HSA-742345 molecular_function owl:Class
GO:0015783 biolink:NamedThing GDP-fucose transmembrane transport The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate. got7fsn_ti GDP-fucose transport biological_process owl:Class
GO:0015790 biolink:NamedThing UDP-xylose transmembrane transport The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate. got7fsn_ti UDP-xylose transport biological_process owl:Class
GO:0043684 biolink:NamedThing type IV secretion system complex A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s). got7fsn_ti type IV protein secretion system complex|T4SS complex cellular_component owl:Class
GO:0009640 biolink:NamedThing photomorphogenesis The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis. got7fsn_ti plant development in response to light Wikipedia:Photomorphogenesis biological_process owl:Class
GO:0046727 biolink:NamedThing capsomere Any of the protein subunits that comprise the closed shell or coat (capsid) of certain viruses. got7fsn_ti capsomer Wikipedia:Capsomere cellular_component owl:Class
GO:0019028 biolink:NamedThing viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. got7fsn_ti GO:0046728 Wikipedia:Capsid cellular_component owl:Class
GO:1903947 biolink:NamedThing positive regulation of ventricular cardiac muscle cell action potential Any process that activates or increases the frequency, rate or extent of ventricular cardiac muscle cell action potential. got7fsn_ti up regulation of ventricular cardiac muscle cell action potential|upregulation of ventricular cardiac muscle cell action potential|activation of ventricular cardiac muscle cell action potential|up-regulation of ventricular cardiac muscle cell action potential nc 2015-02-20T14:32:04Z biological_process owl:Class
GO:0010923 biolink:NamedThing negative regulation of phosphatase activity Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. got7fsn_ti biological_process owl:Class
GO:0016311 biolink:NamedThing dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. got7fsn_ti Wikipedia:Dephosphorylation biological_process owl:Class
GO:0039708 biolink:NamedThing nuclear capsid assembly The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly. got7fsn_ti bf 2013-11-28T15:08:41Z VZ:1516 biological_process owl:Class
GO:0046594 biolink:NamedThing maintenance of pole plasm mRNA location The process of maintaining mRNA in a specific location in the oocyte pole plasm. An example of this process is found in Drosophila melanogaster. got7fsn_ti maintenance of oocyte pole plasm mRNA localization|maintenance of pole plasm mRNA localization GO:0048122 biological_process owl:Class
GO:0060016 biolink:NamedThing granulosa cell development The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate. got7fsn_ti biological_process owl:Class
GO:0060014 biolink:NamedThing granulosa cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a granulosa cell, a supporting cell for the developing female gamete in the ovary of mammals. got7fsn_ti biological_process owl:Class
GO:0034080 biolink:NamedThing CENP-A containing nucleosome assembly The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. got7fsn_ti CENP-A containing nucleosome assembly at centromere|DNA replication-independent nucleosome assembly at centromere|centromeric DNA replication-independent nucleosome assembly|centromere-specific histone exchange|centromere specific nucleosome exchange|CENP-A loading|CenH3-containing nucleosome assembly at centromere|CENP-A deposition GO:0034509 biological_process owl:Class
GO:0002397 biolink:NamedThing MHC class I protein complex assembly The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules. got7fsn_ti biological_process owl:Class
GO:0070993 biolink:NamedThing translation preinitiation complex A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. got7fsn_ti mah 2009-10-30T01:25:00Z cellular_component owl:Class
GO:0061265 biolink:NamedThing mesonephric nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the mesonephric nephron tubule as it progresses from its formation to the mature state. got7fsn_ti dph 2010-08-30T03:02:09Z biological_process owl:Class
GO:0030726 biolink:NamedThing male germline ring canal formation Formation of the intercellular bridges that connect the germ-line cells of a male cyst. got7fsn_ti testicular ring canal formation|spermatocyte ring canal formation biological_process owl:Class
GO:0001121 biolink:NamedThing bacterial transcription The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter. got7fsn_ti transcription from bacterial-type RNA polymerase promoter https://github.com/geneontology/go-ontology/issues/14854 krc 2010-12-06T03:32:13Z biological_process owl:Class
GO:0071692 biolink:NamedThing protein localization to extracellular region Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location. got7fsn_ti protein localization in extracellular region|protein localisation in extracellular region mah 2010-02-25T04:00:13Z biological_process owl:Class
GO:1902117 biolink:NamedThing positive regulation of organelle assembly Any process that activates or increases the frequency, rate or extent of organelle assembly. got7fsn_ti up-regulation of organelle assembly|activation of organelle assembly|upregulation of organelle assembly|up regulation of organelle assembly pr 2013-05-14T09:43:36Z biological_process owl:Class
GO:0033025 biolink:NamedThing regulation of mast cell apoptotic process Any process that modulates the frequency, rate, or extent of mast cell apoptotic process. got7fsn_ti regulation of mast cell apoptosis biological_process owl:Class
GO:0045281 biolink:NamedThing succinate dehydrogenase complex A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones. got7fsn_ti cellular_component owl:Class
GO:0061840 biolink:NamedThing high-affinity ferrous iron transmembrane transporter activity Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity ferrous uptake transmembrane transporter activity|high-affinity ferrous iron uptake transmembrane transporter activity molecular_function owl:Class
GO:0002526 biolink:NamedThing acute inflammatory response Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. got7fsn_ti biological_process owl:Class
GO:0060126 biolink:NamedThing somatotropin secreting cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a somatotropin secreting cell. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. got7fsn_ti somatotrophin secreting cell differentiation|somatotrope differentiation|somatotroph differentiation|somatrophic cell differentiation|somatotropic cell differentiation|growth hormone secreting cell differentiation biological_process owl:Class
GO:1903059 biolink:NamedThing regulation of protein lipidation Any process that modulates the frequency, rate or extent of protein lipidation. got7fsn_ti regulation of protein amino acid lipidation|regulation of lipid:protein modification rph 2014-05-28T13:21:18Z biological_process owl:Class
GO:0042157 biolink:NamedThing lipoprotein metabolic process The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. got7fsn_ti lipoprotein metabolism biological_process owl:Class
GO:0006408 biolink:NamedThing snRNA export from nucleus The directed movement of snRNA from the nucleus to the cytoplasm. got7fsn_ti snRNA transport from nucleus to cytoplasm|snRNA-nucleus export|snRNA export out of nucleus|snRNA export from cell nucleus biological_process owl:Class
GO:0035964 biolink:NamedThing COPI-coated vesicle budding The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle. got7fsn_ti COPI vesicle budding bf 2011-08-01T11:32:23Z biological_process owl:Class
GO:0009578 biolink:NamedThing etioplast stroma The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA. got7fsn_ti cellular_component owl:Class
GO:0009533 biolink:NamedThing chloroplast stromal thylakoid Unstacked thylakoids that connect the grana stacks through the stroma. got7fsn_ti cellular_component owl:Class
GO:0010377 biolink:NamedThing guard cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere. got7fsn_ti stomatal cell fate commitment biological_process owl:Class
GO:0140673 biolink:NamedThing co-transcriptional chromatin reassembly The reestablishment of chromatin structure that was disrupted upon passage of RNA polymerase II during transcription elongation. This process prevents cryptic intragenic transcription initiation. got7fsn_ti maintainance of chromatin integrity during transcription elongation by RNAPII|euchromatin maintenance during transcription elongation|chromatin maintenance during transcription elongation|maintenance of transcriptionally active chromatin during transcription elongation https://github.com/geneontology/go-ontology/issues/21730 Note: Do not confuse with GO:0048096 chromatin-mediated maintenance of transcription, which describes the maintenance of chromatin in an open conformation (indeendent of transcription). pg 2021-06-29T09:18:46Z biological_process owl:Class
GO:0007421 biolink:NamedThing stomatogastric nervous system development The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0015628 biolink:NamedThing protein secretion by the type II secretion system The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. got7fsn_ti protein secretion by the type II protein secretion system|protein secretion by the T2SS|protein secretion by the T2S|protein secretion by the general secretory pathway|type II protein secretion system|protein secretion by the general secretion pathway Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. biological_process owl:Class
GO:0097745 biolink:NamedThing mitochondrial tRNA 5'-end processing The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion. got7fsn_ti pr 2016-11-08T10:50:51Z biological_process owl:Class
GO:0048759 biolink:NamedThing xylem vessel member cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened. got7fsn_ti vessel element cell differentiation|vessel member cell differentiation biological_process owl:Class
GO:0010089 biolink:NamedThing xylem development The formation of the principal water-conducting tissue of a vascular plant. got7fsn_ti xylem histogenesis biological_process owl:Class
GO:0004906 biolink:NamedThing interferon-gamma receptor activity Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti type II interferon receptor activity|IFNG receptor activity|IFN-gamma receptor activity molecular_function owl:Class
GO:0019964 biolink:NamedThing interferon-gamma binding Binding to interferon-gamma. Interferon gamma is the only member of the type II interferon found so far. got7fsn_ti IFN-gamma binding|type II interferon binding|IFNG binding molecular_function owl:Class
GO:0031586 biolink:NamedThing negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. got7fsn_ti downregulation of IP3 receptor activity|down-regulation of IP3 receptor activity|down regulation of IP3 receptor activity|negative regulation of inositol 1,4,5-trisphosphate receptor activity|inhibition of IP3 receptor activity|negative regulation of IP3 receptor activity biological_process owl:Class
GO:0071022 biolink:NamedThing U12-type post-spliceosomal complex A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U12 and U6atac. got7fsn_ti mammalian U12-type spliceosomal complex C2|minor post-spliceosomal complex|AT-AC post-spliceosomal complex|yeast U12-type spliceosomal complex A2-3 mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0014816 biolink:NamedThing skeletal muscle satellite cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a satellite cell. got7fsn_ti biological_process owl:Class
GO:1900144 biolink:NamedThing positive regulation of BMP secretion Any process that activates or increases the frequency, rate or extent of BMP secretion. got7fsn_ti up-regulation of BMP secretion|up regulation of bone morphogenetic protein secretion|up-regulation of bone morphogenetic protein secretion|activation of BMP secretion|activation of bone morphogenetic protein secretion|upregulation of bone morphogenetic protein secretion|up regulation of BMP protein secretion|upregulation of BMP secretion|positive regulation of BMP protein secretion|up regulation of BMP secretion|upregulation of BMP protein secretion|positive regulation of bone morphogenetic protein secretion|up-regulation of BMP protein secretion|activation of BMP protein secretion sart 2012-03-06T10:31:47Z biological_process owl:Class
GO:0042008 biolink:NamedThing interleukin-18 receptor activity Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-18 receptor activity|IL-18R molecular_function owl:Class
GO:0042007 biolink:NamedThing interleukin-18 binding Binding to interleukin-18. got7fsn_ti IL-18 binding molecular_function owl:Class
GO:0009433 biolink:NamedThing bacterial-type flagellum basal body, C ring Cytoplasmic ring located at the base of the bacterial-type flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. got7fsn_ti flagellar basal body, C ring|flagellin-based flagellum basal body, C ring cellular_component owl:Class
GO:0016528 biolink:NamedThing sarcoplasm The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum. got7fsn_ti Wikipedia:Sarcoplasm cellular_component owl:Class
GO:0031629 biolink:NamedThing synaptic vesicle fusion to presynaptic active zone membrane Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. got7fsn_ti synaptic vesicle fusion to presynaptic membrane|synaptic vesicle fusion|synaptic vesicle fusion to pre-synaptic membrane biological_process owl:Class
GO:0051386 biolink:NamedThing regulation of neurotrophin TRK receptor signaling pathway Any process that modulates the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. got7fsn_ti regulation of NGF receptor signaling pathway|regulation of NGF receptor signalling pathway|regulation of nerve growth factor receptor signalling pathway|regulation of nerve growth factor receptor signaling pathway biological_process owl:Class
GO:0009291 biolink:NamedThing unidirectional conjugation The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in prokaryotes. got7fsn_ti biological_process owl:Class
GO:0044520 biolink:NamedThing envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism. got7fsn_ti envenomation resulting in positive regulation of VIP receptor activity in other organism jl 2012-02-26T11:55:46Z biological_process owl:Class
GO:0019531 biolink:NamedThing oxalate transmembrane transporter activity Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. got7fsn_ti oxalic acid transporter activity molecular_function owl:Class
GO:0019532 biolink:NamedThing oxalate transport The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. got7fsn_ti ethanedioic acid transport|ethanedioate transport|oxalic acid transport biological_process owl:Class
NCBITaxon:4762 biolink:NamedThing got7fsn_ti owl:Class
GO:0090688 biolink:NamedThing cleavage furrow rim The part of the cleavage furrow closest to the cell surface. got7fsn_ti tb 2016-07-26T16:00:10Z cellular_component owl:Class
GO:0033315 biolink:NamedThing meiotic G2/MI DNA replication checkpoint signaling A signal transduction process that controls the G2/M1 transition of the meiotic cell cycle and prevents the initiation of nuclear division until DNA replication is complete. got7fsn_ti meiotic cell cycle DNA replication checkpoint|meiotic G2/MI DNA replication checkpoint|signal transduction involved in meiotic DNA replication checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072440 biological_process owl:Class
GO:0008315 biolink:NamedThing G2/MI transition of meiotic cell cycle The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I. got7fsn_ti meiotic cell cycle G2/MI phase transition|meiotic G2/MI phase transition|meiotic G2/MI transition biological_process owl:Class
GO:0046612 biolink:NamedThing lysosomal proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. got7fsn_ti lysosomal hydrogen ion-transporting ATPase V1 domain cellular_component owl:Class
GO:0046611 biolink:NamedThing lysosomal proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the lysosomal membrane, where it acts as a proton pump to mediate acidification of the lysosomal lumen. got7fsn_ti lysosomal membrane hydrogen-transporting ATPase|lysosomal hydrogen-translocating V-type ATPase complex cellular_component owl:Class
GO:0070519 biolink:NamedThing alpha4-beta1 integrin-CD63 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to membrane protein CD63, a member of the tetraspan family. got7fsn_ti ITGA4-ITGB1-CD63 complex cellular_component owl:Class
GO:0001699 biolink:NamedThing acetylcholine-induced gastric acid secretion The regulated release of gastric acid by parietal cells in response to acetylcholine. got7fsn_ti biological_process owl:Class
GO:0090299 biolink:NamedThing regulation of neural crest formation Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds. got7fsn_ti tb 2010-03-12T04:08:26Z biological_process owl:Class
GO:1905297 biolink:NamedThing positive regulation of neural crest cell fate specification Any process that activates or increases the frequency, rate or extent of neural crest cell fate specification. got7fsn_ti up-regulation of neural crest cell fate specification|upregulation of neural crest cell fate specification|activation of neural crest cell fate specification|up regulation of neural crest cell fate specification rl 2016-06-28T15:14:57Z biological_process owl:Class
GO:1904785 biolink:NamedThing regulation of asymmetric protein localization involved in cell fate determination Any process that modulates the frequency, rate or extent of asymmetric protein localization involved in cell fate determination. got7fsn_ti regulation of asymmetric protein localisation involved in cell fate determination|regulation of asymmetric protein localization resulting in cell fate commitment|regulation of asymmetric protein localization involved in cell fate commitment|regulation of cell fate commitment, asymmetric protein localization wrm-1 in C. Elegans (Q10953) in PMID:17476329 (IMP) es 2015-11-03T12:11:06Z biological_process owl:Class
GO:0035288 biolink:NamedThing anterior head segmentation Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments. got7fsn_ti procephalic segmentation See also the fly_anatomy.ontology term 'procephalic segment ; FBbt:00000007' and its children. biological_process owl:Class
GO:0097065 biolink:NamedThing anterior head development The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure. got7fsn_ti pr 2011-06-08T12:38:11Z biological_process owl:Class
GO:0098561 biolink:NamedThing methyl accepting chemotaxis protein complex A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus. got7fsn_ti A number of complexes of this class are found in E.coli. cellular_component owl:Class
GO:2000709 biolink:NamedThing regulation of maintenance of meiotic sister chromatid cohesion, centromeric Any process that modulates the frequency, rate or extent of maintenance of meiotic sister chromatid cohesion in the centromeric region. got7fsn_ti regulation of maintenance of meiotic sister chromatin cohesion at centromere|regulation of maintenance of centromeric meiotic sister chromatin cohesion|regulation of maintenance of sister chromatin cohesion at centromere at meiosis I mah 2011-06-01T12:41:11Z biological_process owl:Class
GO:0038144 biolink:NamedThing ERBB4:ERBB2 complex A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4. got7fsn_ti ERBB4:ERBB2 heterodimer|NRGs/EGFLs:ERBB4:ERBB2 bf 2012-03-30T02:24:01Z cellular_component owl:Class
GO:0022620 biolink:NamedThing vegetative cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube. got7fsn_ti tube cell differentiation biological_process owl:Class
GO:0106093 biolink:NamedThing EDS1 disease-resistance complex A plant complex involved in basal disease resistance and resistance (R) gene-mediated effector triggered immunity (ETI). Regulates accumulation of the hormone salicylic acid (SA) which is a necessary component of systemic immunity. Involved in responds to bacteria, viruses and oomycetes. got7fsn_ti EDS1-SAG101 complex|EDS1-PAD4 complex|EDS1-PAD4-SAG101 complex Interacts with the R genes triggering ETI and systemic resistance. hjd 2018-01-29T20:02:47Z cellular_component owl:Class
GO:0001507 biolink:NamedThing acetylcholine catabolic process in synaptic cleft The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission. got7fsn_ti acetylcholine breakdown in synaptic cleft|acetylcholine degradation in synaptic cleft biological_process owl:Class
GO:0048286 biolink:NamedThing lung alveolus development The process whose specific outcome is the progression of the alveolus over time, from its formation to the mature structure. The alveolus is a sac for holding air in the lungs; formed by the terminal dilation of air passageways. got7fsn_ti alveolarization|alveologenesis biological_process owl:Class
GO:1990936 biolink:NamedThing vascular associated smooth muscle cell dedifferentiation The process in which a vascular smooth muscle cell (a non-striated, elongated, spindle-shaped cell found lining the blood vessels) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. got7fsn_ti vascular smooth muscle cell dedifferentiation tb 2016-03-22T20:25:11Z biological_process owl:Class
GO:0052606 biolink:NamedThing chlorophyllide a oxygenase activity Catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O. got7fsn_ti chlorophyll a oxygenase activity|chlorophyllide a:oxygen 7-oxidoreductase activity|chlorophyllide-a oxygenase activity|CAO activity RHEA:22676|KEGG_REACTION:R08203|MetaCyc:RXN-7676 molecular_function owl:Class
GO:1903623 biolink:NamedThing negative regulation of RNA polymerase III activity Any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity. got7fsn_ti downregulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter|down regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter|down-regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter|downregulation of RNA polymerase III activity|inhibition of RNA polymerase III activity|negative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter|down regulation of RNA polymerase III activity|down-regulation of RNA polymerase III activity|inhibition of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter al 2014-11-19T18:24:37Z biological_process owl:Class
GO:0061604 biolink:NamedThing molybdopterin-synthase sulfurtransferase activity Catalysis of the reaction: [Molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine <=> AMP [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + cysteine desulfurase. got7fsn_ti dph 2014-02-11T11:56:16Z EC:2.8.1.11|RHEA:48612 molecular_function owl:Class
CHEBI:64628 biolink:NamedThing got7fsn_ti owl:Class
GO:0043402 biolink:NamedThing glucocorticoid mediated signaling pathway A series of molecular signals mediated by the detection of a glucocorticoid hormone. got7fsn_ti glucocorticoid mediated signalling biological_process owl:Class
GO:0071385 biolink:NamedThing cellular response to glucocorticoid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. got7fsn_ti mah 2009-12-11T03:53:56Z biological_process owl:Class
GO:2000301 biolink:NamedThing negative regulation of synaptic vesicle exocytosis Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis. got7fsn_ti dph 2011-01-03T08:21:00Z biological_process owl:Class
GO:0051256 biolink:NamedThing mitotic spindle midzone assembly The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone. got7fsn_ti spindle midzone formation involved in mitosis|spindle midzone assembly involved in mitosis|mitotic spindle midzone biogenesis|mitotic spindle midzone biosynthesis|mitotic spindle midzone formation|spindle midzone biogenesis involved in mitosis biological_process owl:Class
GO:0005865 biolink:NamedThing striated muscle thin filament Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils. got7fsn_ti cellular_component owl:Class
GO:0030017 biolink:NamedThing sarcomere The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. got7fsn_ti Wikipedia:Sarcomere cellular_component owl:Class
GO:0098774 biolink:NamedThing curli A proteinaceous extracellular fiber, produced by an enteric bacterium, that is involved in surface and cell-cell contacts that promote community behavior and host colonization. got7fsn_ti thin aggregative fimbrae|tafi cellular_component owl:Class
GO:0097311 biolink:NamedThing bacterial biofilm matrix A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. got7fsn_ti pr 2012-05-24T11:20:50Z cellular_component owl:Class
GO:1990876 biolink:NamedThing cytoplasmic side of nuclear pore The side of the nuclear pore complex (NPC) that faces the cytoplasm. got7fsn_ti cytoplasmic side of NPC|cytoplasmic side of nucleopore|cytoplasmic side of nuclear pore complex sl 2015-10-01T21:47:54Z cellular_component owl:Class
GO:0051294 biolink:NamedThing establishment of spindle orientation Any process that set the alignment of spindle relative to other cellular structures. got7fsn_ti spindle orientation|orienting of spindle biological_process owl:Class
GO:0021530 biolink:NamedThing spinal cord oligodendrocyte cell fate specification The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. got7fsn_ti biological_process owl:Class
GO:0036179 biolink:NamedThing osteoclast maturation A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes. got7fsn_ti chondroclast maturation bf 2012-03-29T02:04:00Z biological_process owl:Class
GO:0070718 biolink:NamedThing alphaPDGFR-SHP-2 complex A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway. got7fsn_ti PDGFRA-SHP-2 complex, PDGF stimulated mah 2009-06-10T05:00:43Z cellular_component owl:Class
GO:1990633 biolink:NamedThing mutator focus A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules. got7fsn_ti kmv 2015-02-10T20:24:02Z cellular_component owl:Class
GO:0044207 biolink:NamedThing translation initiation ternary complex A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). got7fsn_ti Met-tRNA/eIF2.GTP ternary complex|translation initiation (ternary) complex jl 2009-10-22T02:38:55Z cellular_component owl:Class
GO:0002246 biolink:NamedThing wound healing involved in inflammatory response The series of events that restore integrity to damaged tissue that contribute to an inflammatory response. got7fsn_ti healing during inflammatory response|inflammatory response wound healing biological_process owl:Class
GO:0090594 biolink:NamedThing inflammatory response to wounding The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents. got7fsn_ti tb 2014-08-12T12:13:53Z biological_process owl:Class
GO:0086062 biolink:NamedThing voltage-gated sodium channel activity involved in Purkinje myocyte action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti dph 2011-11-17T01:50:43Z molecular_function owl:Class
GO:1905300 biolink:NamedThing positive regulation of intestinal epithelial cell development Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development. got7fsn_ti up-regulation of intestinal epithelial cell development|upregulation of intestinal epithelial cell development|activation of intestinal epithelial cell development|up regulation of intestinal epithelial cell development rph 2016-06-30T11:41:02Z biological_process owl:Class
GO:1901892 biolink:NamedThing negative regulation of cell septum assembly Any process that stops, prevents or reduces the frequency, rate or extent of cell septum assembly. got7fsn_ti down regulation of cell septum assembly|down-regulation of cell septum assembly|downregulation of cell septum assembly|inhibition of cell septum assembly tb 2013-02-06T20:14:45Z biological_process owl:Class
GO:0002297 biolink:NamedThing T-helper 2 cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy. got7fsn_ti T-helper 2 cell fate commitment|Th2 fate commitment biological_process owl:Class
GO:0045064 biolink:NamedThing T-helper 2 cell differentiation The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4. got7fsn_ti T-helper 2 cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0043493 biolink:NamedThing viral terminase complex A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides. got7fsn_ti virus terminase complex|phage terminase complex cellular_component owl:Class
GO:0017177 biolink:NamedThing glucosidase II complex A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins. got7fsn_ti alpha-glucosidase II complex Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term. cellular_component owl:Class
GO:0090661 biolink:NamedThing box H/ACA telomerase RNP complex A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell. got7fsn_ti tb 2015-09-21T14:46:16Z cellular_component owl:Class
GO:0032212 biolink:NamedThing positive regulation of telomere maintenance via telomerase Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase. got7fsn_ti upregulation of telomere maintenance via telomerase activity|up regulation of telomere maintenance via telomerase activity|stimulation of telomere maintenance via telomerase|up-regulation of telomere maintenance via telomerase activity|activation of telomere maintenance via telomerase biological_process owl:Class
GO:0060856 biolink:NamedThing establishment of blood-brain barrier Establishment of the barrier between the blood and the brain. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. got7fsn_ti establishment of blood/brain barrier|establishment of BBB dph 2009-08-12T12:12:59Z biological_process owl:Class
GO:0035565 biolink:NamedThing regulation of pronephros size Any process that modulates the size of a pronephric kidney. got7fsn_ti regulation of pronephric kidney size bf 2010-07-23T11:28:57Z biological_process owl:Class
GO:0052721 biolink:NamedThing regulation of apurinic/apyrimidinic endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of apurinic/apyrimidinic (AP) endodeoxyribonuclease activity, the hydrolysis of ester linkages immediately 5' to an AP (also called abasic) site within a deoxyribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. got7fsn_ti regulation of abasic endodeoxyribonuclease activity|regulation of apurinic endodeoxyribonuclease activity|regulation of apyrimidinic endodeoxyribonuclease activity|regulation of AP endodeoxyribonuclease activity biological_process owl:Class
GO:0120273 biolink:NamedThing ciliary centrin arm assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a ciliary centrin arm, a rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules. got7fsn_ti ciliary centrin arm formation https://github.com/geneontology/go-ontology/issues/20088 krc 2020-10-08T23:01:46Z biological_process owl:Class
GO:0005795 biolink:NamedThing Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. got7fsn_ti dictyosome|Golgi cisternae GO:0016940 cellular_component owl:Class
GO:0036101 biolink:NamedThing leukotriene B4 catabolic process The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. got7fsn_ti LTB4 catabolism|leukotriene B4 breakdown|leukotriene B4 catabolism|leukotriene B4 degradation bf 2012-01-27T01:26:24Z biological_process owl:Class
GO:0009553 biolink:NamedThing embryo sac development The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate. got7fsn_ti female gametophyte development GO:0048230 biological_process owl:Class
GO:0010260 biolink:NamedThing animal organ senescence The process that occurs in an animal organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. got7fsn_ti GO:0010261 biological_process owl:Class
GO:0042470 biolink:NamedThing melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. got7fsn_ti Wikipedia:Melanosome cellular_component owl:Class
GO:0036504 biolink:NamedThing Golgi membrane fusion The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane. got7fsn_ti post-mitotic fusion of Golgi membranes|membrane fusion involved in Golgi reassembly bf 2015-05-21T10:05:06Z biological_process owl:Class
GO:0090168 biolink:NamedThing Golgi reassembly The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance. got7fsn_ti tb 2009-12-08T09:15:11Z biological_process owl:Class
GO:0042773 biolink:NamedThing ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. got7fsn_ti biological_process owl:Class
GO:0048916 biolink:NamedThing posterior lateral line development The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear. got7fsn_ti PLL development biological_process owl:Class
GO:0021783 biolink:NamedThing preganglionic parasympathetic fiber development The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion. got7fsn_ti biological_process owl:Class
GO:0021607 biolink:NamedThing accessory nerve morphogenesis The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. got7fsn_ti CN XI morphogenesis biological_process owl:Class
GO:0021565 biolink:NamedThing accessory nerve development The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. got7fsn_ti CN XI development|cranial nerve 11 development|cranial nerve XI development|spinal accessory nerve development biological_process owl:Class
GO:0021697 biolink:NamedThing cerebellar cortex formation The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. got7fsn_ti biological_process owl:Class
GO:0021574 biolink:NamedThing rhombomere 8 development The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0021896 biolink:NamedThing forebrain astrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. got7fsn_ti biological_process owl:Class
GO:0032585 biolink:NamedThing multivesicular body membrane The lipid bilayer surrounding a multivesicular body. got7fsn_ti MVB membrane|multivesicular endosome membrane|MVE membrane cellular_component owl:Class
GO:0048342 biolink:NamedThing paraxial mesodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a paraxial mesoderm cell. got7fsn_ti biological_process owl:Class
GO:0009576 biolink:NamedThing leucoplast stroma The space enclosed by the double membrane of a leucoplast. got7fsn_ti cellular_component owl:Class
NCBITaxon:32443 biolink:NamedThing got7fsn_ti owl:Class
GO:0007355 biolink:NamedThing anterior region determination Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product. got7fsn_ti biological_process owl:Class
GO:0120224 biolink:NamedThing larynx development The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration. got7fsn_ti krc 2020-02-24T17:13:10Z biological_process owl:Class
GO:0061914 biolink:NamedThing negative regulation of growth plate cartilage chondrocyte proliferation Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population. got7fsn_ti dph 2017-07-10T17:39:17Z biological_process owl:Class
GO:0035265 biolink:NamedThing organ growth The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function. got7fsn_ti biological_process owl:Class
GO:0003246 biolink:NamedThing embryonic cardiac muscle cell growth involved in heart morphogenesis The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart. got7fsn_ti embryonic cardiac muscle physiological hypertrophy dph 2009-10-13T11:46:23Z biological_process owl:Class
GO:0003245 biolink:NamedThing cardiac muscle tissue growth involved in heart morphogenesis The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. got7fsn_ti dph 2009-10-13T11:44:21Z biological_process owl:Class
GO:0021659 biolink:NamedThing rhombomere 3 structural organization The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 3 structural organisation biological_process owl:Class
GO:0015179 biolink:NamedThing L-amino acid transmembrane transporter activity Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. got7fsn_ti L-amino acid transporter activity Reactome:R-HSA-212614 molecular_function owl:Class
GO:1902475 biolink:NamedThing L-alpha-amino acid transmembrane transport The directed movement of L-alpha-amino acid across a membrane. got7fsn_ti kmv 2013-10-25T15:17:39Z biological_process owl:Class
GO:1990527 biolink:NamedThing Tec1p-Ste12p-Dig1p complex A multiprotein complex that is involved in the transcriptional regulation of primarily filamentation genes, but also mating genes, in the yeast S. cerevisiae. got7fsn_ti rb 2014-11-05T22:55:17Z cellular_component owl:Class
GO:0007532 biolink:NamedThing regulation of mating-type specific transcription, DNA-templated Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription. got7fsn_ti regulation of mating-type specific transcription, DNA-dependent|mating-type specific transcriptional control biological_process owl:Class
GO:1902618 biolink:NamedThing cellular response to fluoride Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoride stimulus. got7fsn_ti kmv 2014-01-10T19:41:58Z biological_process owl:Class
GO:0045137 biolink:NamedThing development of primary sexual characteristics The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion. got7fsn_ti biological_process owl:Class
GO:1900257 biolink:NamedThing negative regulation of beta1-adrenergic receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of beta1-adrenergic receptor activity. got7fsn_ti down-regulation of beta1-adrenergic receptor activity|inhibition of beta1 adrenoceptor|down regulation of beta1 adrenoceptor|downregulation of beta1-adrenergic receptor activity|down-regulation of beta1 adrenoceptor|negative regulation of beta1 adrenoceptor|down regulation of beta1-adrenergic receptor activity|downregulation of beta1 adrenoceptor|inhibition of beta1-adrenergic receptor activity tb 2012-04-03T10:59:40Z biological_process owl:Class
GO:0044614 biolink:NamedThing nuclear pore cytoplasmic filaments Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component. got7fsn_ti cytoplasmic fibers of the nuclear pore complex|cytoplasmic fibers of the NPC jl 2012-06-20T01:28:18Z cellular_component owl:Class
GO:1903934 biolink:NamedThing positive regulation of DNA primase activity Any process that activates or increases the frequency, rate or extent of DNA primase activity. got7fsn_ti up regulation of DNA primase activity|upregulation of DNA primase activity|activation of DNA primase activity|up-regulation of DNA primase activity mah 2015-02-12T14:28:45Z biological_process owl:Class
GO:2001258 biolink:NamedThing negative regulation of cation channel activity Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. got7fsn_ti negative regulation of nonselective cation channel activity|negative regulation of cation diffusion facilitator activity vk 2011-12-07T07:14:51Z biological_process owl:Class
GO:0021754 biolink:NamedThing facial nucleus development The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0060502 biolink:NamedThing epithelial cell proliferation involved in lung morphogenesis The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung. got7fsn_ti biological_process owl:Class
GO:0003231 biolink:NamedThing cardiac ventricle development The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart. got7fsn_ti dph 2009-10-13T11:03:16Z biological_process owl:Class
GO:0008079 biolink:NamedThing translation termination factor activity Functions in the termination of translation. got7fsn_ti molecular_function owl:Class
GO:0005635 biolink:NamedThing nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). got7fsn_ti GO:0005636 Wikipedia:Nuclear_envelope cellular_component owl:Class
GO:0021838 biolink:NamedThing motogenic signaling involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex. got7fsn_ti motogenic signalling involved in interneuron migration from the subpallium to the cortex biological_process owl:Class
GO:0007502 biolink:NamedThing digestive tract mesoderm development The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism. got7fsn_ti biological_process owl:Class
GO:0045270 biolink:NamedThing plasma membrane proton-transporting ATP synthase, central stalk One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species. got7fsn_ti hydrogen-transporting ATP synthase, central stalk|proton-transporting ATP synthase, central stalk cellular_component owl:Class
GO:0061440 biolink:NamedThing kidney vasculature development The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure. got7fsn_ti dph 2012-03-08T12:39:09Z biological_process owl:Class
GO:0000156 biolink:NamedThing phosphorelay response regulator activity Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response. got7fsn_ti two-component response regulator activity https://github.com/geneontology/go-ontology/issues/15611 molecular_function owl:Class
GO:0000160 biolink:NamedThing phosphorelay signal transduction system A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. got7fsn_ti phosphorelay signal transduction system|histidyl-aspartyl phosphorelay biological_process owl:Class
GO:0005381 biolink:NamedThing iron ion transmembrane transporter activity Enables the transfer of iron (Fe) ions from one side of a membrane to the other. got7fsn_ti transmembrane iron ion permease activity|iron transporter activity|iron channel activity|transmembrane iron permease activity|multicopper ferroxidase iron transport mediator activity|iron cation channel activity|zinc, iron permease activity https://github.com/geneontology/go-ontology/issues/17162 An example of this is mouse ferroportin (UniProtKB:Q9JHI9), which transports iron out of the cell. GO:0016033|GO:0097689|GO:0005382 Reactome:R-HSA-5655733|Reactome:R-HSA-435349|Reactome:R-HSA-5623558|Reactome:R-HSA-917936|Reactome:R-HSA-904830 molecular_function owl:Class
GO:0014056 biolink:NamedThing regulation of acetylcholine secretion, neurotransmission Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine. got7fsn_ti biological_process owl:Class
GO:0036162 biolink:NamedThing oxytocin production The appearance of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG, due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior. It also acts as a neurotransmitter in the brain. got7fsn_ti oxytocin secretion|oxytocin biosynthesis https://github.com/geneontology/go-ontology/issues/9542|https://github.com/geneontology/go-ontology/issues/21535 Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular oxytocin levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting oxytocin molecules, or increased conversion from precursor molecules. bf 2012-03-26T01:43:46Z biological_process owl:Class
GO:1903799 biolink:NamedThing negative regulation of production of miRNAs involved in gene silencing by miRNA Any process that stops, prevents or reduces the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA. got7fsn_ti downregulation of microRNA biosynthetic process|down-regulation of microRNA metabolism|negative regulation of microRNA biosynthesis|down regulation of miRNA-mediated gene silencing, production of miRNAs|inhibition of production of miRNAs involved in gene silencing by miRNA|negative regulation of miRNA-mediated gene silencing, production of miRNAs|downregulation of microRNA metabolic process|downregulation of microRNA biogenesis|inhibition of miRNA-mediated gene silencing, production of miRNAs|downregulation of production of microRNAs involved in gene silencing by microRNA|negative regulation of production of microRNAs involved in gene silencing by microRNA|down-regulation of miRNA processing|down regulation of gene silencing by miRNA, production of miRNAs|negative regulation of microRNA metabolism|inhibition of microRNA biosynthetic process|inhibition of microRNA biosynthesis|inhibition of production of microRNAs involved in gene silencing by microRNA|down-regulation of microRNA-mediated gene silencing, production of microRNAs|down regulation of production of microRNAs involved in gene silencing by microRNA|down-regulation of gene silencing by miRNA, production of miRNAs|down-regulation of production of microRNAs involved in gene silencing by microRNA|negative regulation of microRNA biogenesis|down regulation of miRNA biogenesis|downregulation of microRNA biosynthesis|down regulation of microRNA-mediated gene silencing, production of microRNAs|down-regulation of microRNA biosynthesis|negative regulation of miRNA biogenesis|down-regulation of miRNA biogenesis|downregulation of miRNA processing|down regulation of microRNA metabolism|inhibition of microRNA metabolism|downregulation of gene silencing by miRNA, production of miRNAs|down regulation of microRNA biogenesis|inhibition of microRNA-mediated gene silencing, production of microRNAs|downregulation of miRNA biogenesis|inhibition of microRNA biogenesis|down-regulation of microRNA biosynthetic process|inhibition of microRNA metabolic process|negative regulation of gene silencing by miRNA, production of miRNAs|negative regulation of microRNA-mediated gene silencing, production of microRNAs|negative regulation of microRNA biosynthetic process|down regulation of microRNA biosynthesis|down-regulation of microRNA biogenesis|inhibition of miRNA biogenesis|negative regulation of microRNA metabolic process|inhibition of miRNA processing|downregulation of microRNA metabolism|inhibition of gene silencing by miRNA, production of miRNAs|down-regulation of production of miRNAs involved in gene silencing by miRNA|down-regulation of miRNA-mediated gene silencing, production of miRNAs|negative regulation of miRNA processing|down regulation of production of miRNAs involved in gene silencing by miRNA|downregulation of production of miRNAs involved in gene silencing by miRNA|downregulation of miRNA-mediated gene silencing, production of miRNAs|down-regulation of microRNA metabolic process|down regulation of miRNA processing|down regulation of microRNA metabolic process|downregulation of microRNA-mediated gene silencing, production of microRNAs|down regulation of microRNA biosynthetic process rph 2015-01-15T13:58:22Z biological_process owl:Class
GO:0001961 biolink:NamedThing positive regulation of cytokine-mediated signaling pathway Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway. got7fsn_ti positive regulation of cytokine mediated signalling pathway|activation of cytokine mediated signaling pathway|positive regulation of cytokine and chemokine mediated signaling pathway|up-regulation of cytokine mediated signaling pathway|up regulation of cytokine mediated signaling pathway|stimulation of cytokine mediated signaling pathway|upregulation of cytokine mediated signaling pathway|positive regulation of cytokine mediated signaling pathway biological_process owl:Class
GO:0052706 biolink:NamedThing histidine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine. got7fsn_ti S-adenosyl-L-methionine:L-histidine alpha-N-methyltransferase activity|S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase activity|histidine methyltransferase activity|histidine-alpha-N-methyltransferase activity ai 2011-08-05T11:57:40Z molecular_function owl:Class
GO:0060186 biolink:NamedThing outer ear emergence The growth of the outer ear. got7fsn_ti ear extroversion|ear elevation|outer ear growth biological_process owl:Class
GO:0042473 biolink:NamedThing outer ear morphogenesis The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull. got7fsn_ti biological_process owl:Class
GO:0009431 biolink:NamedThing bacterial-type flagellum basal body, MS ring One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. got7fsn_ti flagellar basal body, MS ring|flagellar basal body, mounting plate|flagellin-based flagellum basal body, MS ring GO:0009430 cellular_component owl:Class
GO:0042721 biolink:NamedThing TIM22 mitochondrial import inner membrane insertion complex A multi-subunit complex embedded in the mitochondrial inner membrane that mediates the inner membrane insertion of multi-transmembrane spanning proteins that contain internal targeting elements. In yeast cells, TIM22 is a 300-kDa complex, consisting of four membrane integral subunits, Tim22, Tim54, Tim18 and Sdh3, and a peripheral chaperone complex consisting of the small TIM proteins, Tim9-Tim10-Tim12. got7fsn_ti mitochondrial protein translocase complex|mitochondrial inner membrane protein insertion complex|Tim22 complex cellular_component owl:Class
GO:0046403 biolink:NamedThing polynucleotide 3'-phosphatase activity Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage. got7fsn_ti polynucleotide 3'-phosphohydrolase activity|5'-polynucleotidekinase 3'-phosphatase activity|2'(3')-polynucleotidase activity|DNA 3'-phosphatase activity|deoxyribonucleate 3'-phosphatase activity Reactome:R-HSA-5649705|EC:3.1.3.32|MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN|RHEA:14113 molecular_function owl:Class
GO:0098506 biolink:NamedThing polynucleotide 3' dephosphorylation The process of removing one or more phosphate groups from the 3' end of a polynucleotide. got7fsn_ti biological_process owl:Class
GO:0035221 biolink:NamedThing genital disc pattern formation The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc. got7fsn_ti biological_process owl:Class
GO:0110038 biolink:NamedThing negative regulation of nematode male tail tip morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of nematode male tail tip morphogenesis. got7fsn_ti kmv 2017-07-24T20:29:00Z biological_process owl:Class
GO:0004901 biolink:NamedThing granulocyte macrophage colony-stimulating factor receptor activity Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti granulocyte macrophage colony stimulating factor receptor activity|GMC-SF receptor activity|CSF-2 receptor activity|GM-CSF receptor activity|CSF2R GO:0030525 molecular_function owl:Class
GO:0042021 biolink:NamedThing granulocyte macrophage colony-stimulating factor complex binding Binding to a granulocyte macrophage colony-stimulating factor complex. got7fsn_ti GMC-SF complex binding|GM-CSF complex binding|granulocyte macrophage colony stimulating factor complex binding molecular_function owl:Class
GO:0072052 biolink:NamedThing juxtaglomerulus cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the juxtaglomerulus cells of the kidney as it progresses from its formation to the mature state. got7fsn_ti mah 2010-01-25T03:58:01Z biological_process owl:Class
GO:0098031 biolink:NamedThing icosahedral viral capsid, collar A small disk located at the base of some icosahedral virus capsids. got7fsn_ti bm 2012-07-19T15:01:12Z cellular_component owl:Class
GO:0031905 biolink:NamedThing early endosome lumen The volume enclosed by the membrane of an early endosome. got7fsn_ti cellular_component owl:Class
GO:0005769 biolink:NamedThing early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. got7fsn_ti NIF_Subcellular:nlx_subcell_20090701 cellular_component owl:Class
GO:0016465 biolink:NamedThing chaperonin ATPase complex Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. got7fsn_ti cellular_component owl:Class
GO:0051319 biolink:NamedThing G2 phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis). got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:G2_phase biological_process owl:Class
GO:0072311 biolink:NamedThing glomerular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glomerular epithelial cell. Glomerular epithelial cells are specialized epithelial cells that form part of the glomerulus; there are two types, glomerular parietal epithelial cells and glomerular visceral epithelial cells. got7fsn_ti mah 2010-04-09T06:49:21Z biological_process owl:Class
GO:0071818 biolink:NamedThing BAT3 complex A protein complex found in mammals that transfers tail-anchored (TA) proteins from SGTA to GET3 (ASNA1/TRC4) for targeting to the endoplasmic reticulum membrane. Also chaperones polypeptides from the endoplasmic reticulum retrotranslocation machinery to the proteasome, maintaining the solubility of substrates to improve ER-associated protein degradation (ERAD). Consists of BAG6 (BAT3) and its cofactors GET4 (TRC35) and UBL4A. got7fsn_ti BAG6-UBL4A-TRC35 complex|Bag6 complex|BAT3-TRC35-UBL4A complex https://github.com/geneontology/go-ontology/issues/20919 mah 2010-09-07T11:01:38Z cellular_component owl:Class
GO:1903071 biolink:NamedThing positive regulation of ER-associated ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of ER-associated ubiquitin-dependent protein catabolic process. got7fsn_ti activation of ERAD|up regulation of ER-associated protein catabolic process|up-regulation of ER-associated protein breakdown|up regulation of endoplasmic reticulum-associated protein catabolism|up regulation of ER-associated protein degradation|positive regulation of ER-associated protein degradation|up-regulation of endoplasmic reticulum-associated protein catabolic process|activation of ER-associated protein catabolism|up-regulation of ER-associated protein catabolic process|up regulation of ER-associated protein catabolism|upregulation of ER-associated protein catabolism|activation of ER-associated protein breakdown|positive regulation of ERAD|upregulation of ER-associated protein catabolic process|upregulation of ERAD|positive regulation of ER-associated protein catabolism|activation of ER-associated protein catabolic process|up regulation of ER-associated ubiquitin-dependent protein catabolic process|activation of ER-associated ubiquitin-dependent protein catabolic process|upregulation of ER-associated protein degradation|activation of endoplasmic reticulum-associated protein catabolism|activation of ER-associated protein degradation|up regulation of ER-associated protein breakdown|activation of endoplasmic reticulum-associated protein catabolic process|up-regulation of endoplasmic reticulum-associated protein catabolism|up-regulation of ER-associated protein degradation|positive regulation of ER-associated protein catabolic process|positive regulation of endoplasmic reticulum-associated protein catabolism|up-regulation of ER-associated protein catabolism|up regulation of ERAD|upregulation of endoplasmic reticulum-associated protein catabolism|upregulation of ER-associated protein breakdown|up regulation of endoplasmic reticulum-associated protein catabolic process|upregulation of ER-associated ubiquitin-dependent protein catabolic process|upregulation of endoplasmic reticulum-associated protein catabolic process|positive regulation of endoplasmic reticulum-associated protein catabolic process|up-regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of ER-associated protein breakdown|up-regulation of ERAD rph 2014-05-28T17:54:04Z biological_process owl:Class
GO:0120118 biolink:NamedThing flagella connector A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum. got7fsn_ti Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. krc 2017-12-11T22:24:17Z cellular_component owl:Class
GO:0008316 biolink:NamedThing structural constituent of vitelline membrane The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster. got7fsn_ti molecular_function owl:Class
GO:0001401 biolink:NamedThing SAM complex A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex. got7fsn_ti mitochondrial sorting and assembly machinery complex|TOB complex See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. cellular_component owl:Class
GO:1903051 biolink:NamedThing negative regulation of proteolysis involved in cellular protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process. got7fsn_ti negative regulation of peptidolysis during cellular protein catabolic process|down regulation of peptidolysis during cellular protein catabolic process|downregulation of proteolysis involved in cellular protein catabolic process|down regulation of proteolysis during cellular protein catabolic process|negative regulation of proteolysis during cellular protein catabolic process|down regulation of peptidolysis during cellular protein catabolism|down-regulation of peptidolysis involved in cellular protein catabolic process|downregulation of peptidolysis during cellular protein catabolism|inhibition of peptidolysis involved in cellular protein catabolic process|inhibition of peptidolysis involved in cellular protein catabolism|negative regulation of peptidolysis during cellular protein catabolism|inhibition of peptidolysis during cellular protein catabolism|down-regulation of peptidolysis during cellular protein catabolic process|downregulation of peptidolysis involved in cellular protein catabolic process|down-regulation of proteolysis during cellular protein catabolic process|down regulation of peptidolysis involved in cellular protein catabolism|inhibition of proteolysis during cellular protein catabolism|down regulation of proteolysis during cellular protein catabolism|down regulation of peptidolysis involved in cellular protein catabolic process|down-regulation of proteolysis during cellular protein catabolism|inhibition of proteolysis involved in cellular protein catabolic process|down-regulation of peptidolysis involved in cellular protein catabolism|down-regulation of peptidolysis during cellular protein catabolism|negative regulation of peptidolysis involved in cellular protein catabolic process|negative regulation of peptidolysis involved in cellular protein catabolism|downregulation of peptidolysis during cellular protein catabolic process|down-regulation of proteolysis involved in cellular protein catabolic process|down regulation of proteolysis involved in cellular protein catabolic process|downregulation of proteolysis during cellular protein catabolic process|inhibition of peptidolysis during cellular protein catabolic process|inhibition of proteolysis during cellular protein catabolic process|negative regulation of proteolysis during cellular protein catabolism|downregulation of proteolysis during cellular protein catabolism|downregulation of peptidolysis involved in cellular protein catabolism Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP). rl 2014-05-22T18:00:51Z biological_process owl:Class
GO:0097734 biolink:NamedThing extracellular exosome biogenesis The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. got7fsn_ti ILV assembly|exosome biogenesis|intraluminal vesicle assembly|exosome production|exosome assembly or secretion pr 2016-10-03T14:35:25Z biological_process owl:Class
GO:0097593 biolink:NamedThing ventral disc microtubule array A part of the ventral disc of Giardia species (trophozoite stage) consisting of a spiral array of microtubules linked to the ventral membrane. These microtubules form the base of the ventral disc dorsal microribbons that extend nearly perpendicular from the membrane. got7fsn_ti ventral disk microtubule array|ventral disc spiral microtubule array|spiral microtubule array Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-04-03T11:17:17Z cellular_component owl:Class
GO:0140010 biolink:NamedThing D-aspartate transmembrane transporter activity Enables the transfer of D-aspartate from one side of a membrane to the other. got7fsn_ti pg 2017-03-13T11:15:15Z molecular_function owl:Class
GO:0070777 biolink:NamedThing D-aspartate transport The directed movement of D-aspartate, the D-enantiomer of the anion of (2R)-2-aminobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti mah 2009-07-02T01:42:57Z biological_process owl:Class
GO:0015550 biolink:NamedThing galacturonate transmembrane transporter activity Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. got7fsn_ti molecular_function owl:Class
GO:0015737 biolink:NamedThing galacturonate transmembrane transport The process in which galacturonate is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti galacturonate transport biological_process owl:Class
GO:0004961 biolink:NamedThing thromboxane A2 receptor activity Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein. got7fsn_ti TXA(2) receptor activity|TXA2 receptor activity molecular_function owl:Class
GO:0038193 biolink:NamedThing thromboxane A2 signaling pathway The series of molecular signals generated as a consequence of thromboxane A2 binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti TXA2 signaling|TXA(2) receptor signaling bf 2013-09-02T16:07:01Z biological_process owl:Class
GO:1900747 biolink:NamedThing negative regulation of vascular endothelial growth factor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway. got7fsn_ti negative regulation of VEGF-activated signaling pathway|down-regulation of VEGF signaling|down-regulation of VEGF-activated signaling pathway|downregulation of VEGF-activated signaling pathway|negative regulation of vascular endothelial growth factor signalling pathway|downregulation of vascular endothelial growth factor signalling pathway|negative regulation of VEGF signaling|down regulation of VEGF-activated signaling pathway|downregulation of vascular endothelial growth factor signaling pathway|down regulation of vascular endothelial growth factor signaling pathway|downregulation of VEGF signaling|inhibition of vascular endothelial growth factor signalling pathway|down regulation of vascular endothelial growth factor signalling pathway|inhibition of vascular endothelial growth factor signaling pathway|inhibition of VEGF-activated signaling pathway|down-regulation of vascular endothelial growth factor signaling pathway|down-regulation of vascular endothelial growth factor signalling pathway|inhibition of VEGF signaling|down regulation of VEGF signaling pm 2012-05-29T08:28:29Z biological_process owl:Class
GO:0050325 biolink:NamedThing tauropine dehydrogenase activity Catalysis of the reaction: H(2)O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine. got7fsn_ti 2-N-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming)|N2-(D-1-carboxyethyl)taurine:NAD+ oxidoreductase (taurine-forming) MetaCyc:TAUROPINE-DEHYDROGENASE-RXN|RHEA:12580|KEGG_REACTION:R01683|EC:1.5.1.23 molecular_function owl:Class
GO:0015167 biolink:NamedThing arabitol transmembrane transporter activity Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. got7fsn_ti arabinitol transporter activity molecular_function owl:Class
GO:0015792 biolink:NamedThing arabinitol transmembrane transport The process in which arabitol is transported across a lipid bilayer, from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms. got7fsn_ti arabinitol transport|arabitol transport biological_process owl:Class
GO:0055108 biolink:NamedThing Golgi to transport vesicle transport The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. got7fsn_ti biological_process owl:Class
GO:0015094 biolink:NamedThing lead ion transmembrane transporter activity Enables the transfer of lead (Pb) ions from one side of a membrane to the other. got7fsn_ti zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity molecular_function owl:Class
GO:0015692 biolink:NamedThing lead ion transport The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0097103 biolink:NamedThing endothelial stalk cell fate specification The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout. got7fsn_ti angiogenic stalk cell fate specification pr 2011-07-27T10:32:38Z biological_process owl:Class
GO:0002040 biolink:NamedThing sprouting angiogenesis The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. got7fsn_ti biological_process owl:Class
GO:0071130 biolink:NamedThing alpha5-beta1 integrin-LPP3 complex A protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3. got7fsn_ti ITGA5-ITGB1-PPAP2B complex mah 2009-11-13T02:25:47Z cellular_component owl:Class
GO:0015736 biolink:NamedThing hexuronate transmembrane transport The process in which hexuronate is transported across a lipid bilayer, from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6. got7fsn_ti hexuronate transport biological_process owl:Class
GO:0061927 biolink:NamedThing TOC-TIC supercomplex I The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110. got7fsn_ti dph 2017-08-28T13:18:20Z cellular_component owl:Class
GO:0060932 biolink:NamedThing His-Purkinje system cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles. got7fsn_ti dph 2009-09-29T01:10:32Z biological_process owl:Class
GO:0090351 biolink:NamedThing seedling development The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge. got7fsn_ti tb 2010-06-10T03:33:10Z PO:0008037 biological_process owl:Class
GO:0009930 biolink:NamedThing longitudinal side of cell surface The side of the cell parallel to the zygotic axis. got7fsn_ti cellular_component owl:Class
GO:0061936 biolink:NamedThing fusion of sperm to egg plasma membrane involved in double fertilization forming a zygote and endosperm The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming a zygote and endosperm. got7fsn_ti dph 2017-09-05T18:43:24Z biological_process owl:Class
GO:0099187 biolink:NamedThing presynaptic cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton. got7fsn_ti dos 2017-12-20T15:05:34Z biological_process owl:Class
GO:0099172 biolink:NamedThing presynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. got7fsn_ti presynapse development|presynapse organisation|presynapse morphogenesis|presynapse organization and biogenesis biological_process owl:Class
GO:0001891 biolink:NamedThing phagocytic cup An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome. got7fsn_ti cellular_component owl:Class
GO:0045756 biolink:NamedThing positive regulation of initiation of acetate catabolic process by acetate Any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. got7fsn_ti up regulation of initiation of acetate catabolic process by acetate|activation of initiation of acetate catabolic process by acetate|stimulation of initiation of acetate catabolic process by acetate|positive regulation of initiation of acetate degradation by acetate|positive regulation of initiation of acetate breakdown by acetate|upregulation of initiation of acetate catabolic process by acetate|up-regulation of initiation of acetate catabolic process by acetate biological_process owl:Class
GO:0072141 biolink:NamedThing renal interstitial fibroblast development The process whose specific outcome is the progression of a renal interstitial fibroblast over time, from its formation to the mature structure. got7fsn_ti kidney interstitial cell development mah 2010-02-24T01:39:05Z biological_process owl:Class
GO:0070927 biolink:NamedThing negative regulation of ATP:ADP antiporter activity Any process that stops or reduces the activity of an ATP:ADP antiporter. got7fsn_ti down-regulation of ATP:ADP antiporter activity|down regulation of ATP:ADP antiporter activity|inhibition of ATP:ADP antiporter activity|downregulation of ATP:ADP antiporter activity mah 2009-09-16T02:58:02Z biological_process owl:Class
GO:1990588 biolink:NamedThing FtsBL complex A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL. got7fsn_ti FtsB-FtsL complex An example of this is FtsB in E. coli (P0A6S5) in PMID:15165235 (inferred from physical interaction). bhm 2014-12-15T09:33:00Z cellular_component owl:Class
GO:0070159 biolink:NamedThing mitochondrial threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA in a mitochondrion, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0019822 biolink:NamedThing P4 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content. got7fsn_ti peroxisome vesicle Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. cellular_component owl:Class
GO:1990201 biolink:NamedThing alkanesulfonate monooxygenase complex A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer. got7fsn_ti SsuD complex bhm 2013-10-03T14:55:08Z cellular_component owl:Class
GO:1901234 biolink:NamedThing positive regulation of convergent extension involved in axis elongation Any process that activates or increases the frequency, rate or extent of convergent extension involved in axis elongation. got7fsn_ti up-regulation of convergent extension involved in axis elongation|upregulation of convergent extension involved in axis elongation|activation of convergent extension involved in axis elongation|up regulation of convergent extension involved in axis elongation vk 2012-08-07T14:22:19Z biological_process owl:Class
GO:0010353 biolink:NamedThing response to trehalose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus. got7fsn_ti response to trehalose stimulus biological_process owl:Class
GO:0007375 biolink:NamedThing anterior midgut invagination Internalization of the anterior midgut into the interior of the embryo. got7fsn_ti biological_process owl:Class
GO:0010004 biolink:NamedThing gastrulation involving germ band extension A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0034045 biolink:NamedThing phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site. got7fsn_ti phagophore|PAS membrane|pre-autophagosomal structure membrane|isolation membrane cellular_component owl:Class
GO:0098591 biolink:NamedThing external side of apical plasma membrane The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. got7fsn_ti dos 2014-03-06T12:04:33Z cellular_component owl:Class
GO:0010006 biolink:NamedThing Toc complex Protein translocon complex at the chloroplast outer membrane. got7fsn_ti cellular_component owl:Class
GO:0042825 biolink:NamedThing TAP complex A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum. got7fsn_ti transporter associated with antigen presentation cellular_component owl:Class
GO:0034306 biolink:NamedThing regulation of sexual sporulation Any process that modulates the frequency, rate or extent of spore formation from the products of meiosis. An example of this is found in Saccharomyces cerevisiae. got7fsn_ti regulation of meiotic sporulation|regulation of meiotic spore formation|regulation of sexual spore formation|MAPKKK cascade during sporulation biological_process owl:Class
GO:1990379 biolink:NamedThing lipid transport across blood-brain barrier The directed movement of lipid molecules passing through the blood-brain barrier. got7fsn_ti lipid transport across blood brain barrier sjp 2014-05-08T09:52:28Z biological_process owl:Class
GO:0009925 biolink:NamedThing basal plasma membrane The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. got7fsn_ti cellular_component owl:Class
GO:0019888 biolink:NamedThing protein phosphatase regulator activity Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. got7fsn_ti protein phosphatase type 1 regulator activity|protein phosphatase type 1, intrinsic regulator activity|protein phosphatase type 4 regulator activity|protein phosphatase 3 regulator activity|calcineurin regulator activity|protein phosphatase type 2A regulator activity|protein phosphatase type 2B, intrinsic regulator activity|protein phosphatase 3, intrinsic regulator activity|protein phosphatase type 4, intrinsic regulator activity|protein phosphatase type 2B regulator activity|calcineurin, intrinsic regulator activity|protein phosphatase 2 regulator activity|protein phosphatase 2, intrinsic regulator activity|protein phosphatase type 2A, intrinsic regulator activity GO:0030359|GO:0008601|GO:0030362|GO:0008599 Reactome:R-HSA-180038 molecular_function owl:Class
GO:0031898 biolink:NamedThing chromoplast envelope The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. got7fsn_ti cellular_component owl:Class
GO:0002336 biolink:NamedThing B-1 B cell lineage commitment The process in which an immature B cell becomes committed to become a B-1 B cell. got7fsn_ti B-1 B lymphocyte lineage commitment|B-1 B-cell lineage commitment|B-1 B-lymphocyte lineage commitment biological_process owl:Class
GO:0001923 biolink:NamedThing B-1 B cell differentiation The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity. got7fsn_ti B-1 B-cell differentiation|B-1 B cell development|B-1 B-lymphocyte differentiation|B-1 B lymphocyte differentiation biological_process owl:Class
GO:0001874 biolink:NamedThing (1->3)-beta-D-glucan immune receptor activity Combining with (1->3)-beta-D-glucans to initiate an innate immune response. got7fsn_ti beta-1,3-D-glucan receptor activity|(1->3)-beta-D-glucan receptor activity|1,3-beta-D-glucan receptor activity|(1,3)-beta-D-glucan receptor activity|zymosan receptor activity molecular_function owl:Class
GO:0001872 biolink:NamedThing (1->3)-beta-D-glucan binding Binding to a (1->3)-beta-D-glucan. got7fsn_ti 1,3-beta-D-glucan binding|zymosan binding|callose binding GO:0080087 molecular_function owl:Class
GO:0060534 biolink:NamedThing trachea cartilage development The process whose specific outcome is the progression of the tracheal cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. got7fsn_ti dph 2009-04-10T09:00:18Z biological_process owl:Class
GO:0002180 biolink:NamedThing 5-lipoxygenase complex An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity. got7fsn_ti hjd 2011-06-09T01:05:53Z cellular_component owl:Class
GO:0097234 biolink:NamedThing epidermal lamellar body membrane The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. got7fsn_ti pr 2012-01-26T10:32:13Z cellular_component owl:Class
GO:0039012 biolink:NamedThing pronephric sinus development The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules. got7fsn_ti bf 2010-07-02T09:55:23Z biological_process owl:Class
GO:0033693 biolink:NamedThing neurofilament bundle assembly The assembly of neurofilaments into bundles, in which the filaments are longitudinally oriented, with numerous crossbridges between them. Neurofilament bundles may be cross-linked to each other, to membrane-bounded organelles or other cytoskeletal structures such as microtubules. got7fsn_ti NF bundle assembly biological_process owl:Class
GO:1990229 biolink:NamedThing iron-sulfur cluster assembly complex A protein complex capable of assembling an iron-sulfur (Fe-S) cluster. got7fsn_ti SufBCD complex|Fe-S cluster assembly complex bhm 2013-11-12T09:15:03Z cellular_component owl:Class
GO:1990182 biolink:NamedThing exosomal secretion The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. got7fsn_ti extracellular vesicular exosome secretion|exosomal protein secretion|exosomal secretory pathway|secretion of exosome|multi-vesicular body fusion with plasma membrane hjd 2013-09-04T21:08:14Z biological_process owl:Class
GO:0001701 biolink:NamedThing in utero embryonic development The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. got7fsn_ti biological_process owl:Class
GO:0061330 biolink:NamedThing Malpighian tubule stellate cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium. got7fsn_ti dph 2010-09-28T01:32:55Z biological_process owl:Class
GO:1990788 biolink:NamedThing GLI-SUFU complex A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins. got7fsn_ti An example of this is SUFU in human (Q9UMX1) in PMID:24311597 (inferred from direct assay). bhm 2015-06-26T13:49:47Z cellular_component owl:Class
GO:0000345 biolink:NamedThing cytosolic DNA-directed RNA polymerase complex The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity. got7fsn_ti cellular_component owl:Class
GO:0003416 biolink:NamedThing endochondral bone growth The increase in size or mass of an endochondral bone that contributes to the shaping of the bone. got7fsn_ti dph 2009-12-22T08:52:55Z biological_process owl:Class
GO:0005006 biolink:NamedThing epidermal growth factor-activated receptor activity Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti transforming growth factor-alpha receptor activity|epidermal growth factor receptor activity|EGFR|TGF-alpha receptor activity|EGF receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand EGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. GO:0005023 molecular_function owl:Class
GO:0039005 biolink:NamedThing specification of pronephric tubule identity The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity. got7fsn_ti bf 2010-07-02T09:33:56Z biological_process owl:Class
GO:0020038 biolink:NamedThing subpellicular network A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton. got7fsn_ti cellular_component owl:Class
GO:0060185 biolink:NamedThing outer ear unfolding The opening and spreading out of the outer ear. got7fsn_ti biological_process owl:Class
GO:0071562 biolink:NamedThing nucleus-vacuole junction assembly The aggregation, arrangement and bonding together of a set of components to form a nucleus-vacuole junction, which are membrane contact sites formed between the vacuole membrane and the outer nuclear membrane. In S. cerevisiae these contacts are mediated through direct physical interaction between Vac8p and Nvj1p. got7fsn_ti NVJ formation|NV junction formation|NVJ assembly|NV junction assembly|nucleus-vacuole junction formation mah 2010-01-20T02:16:36Z biological_process owl:Class
GO:1900161 biolink:NamedThing regulation of phospholipid scramblase activity Any process that modulates the frequency, rate or extent of phospholipid scramblase activity. got7fsn_ti rph 2012-03-08T10:57:19Z biological_process owl:Class
GO:0061835 biolink:NamedThing ventral surface of cell The surface of a migrating cell that is in contact with the substratum or cell layer. got7fsn_ti cellular_component owl:Class
GO:0021687 biolink:NamedThing cerebellar molecular layer morphogenesis The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. got7fsn_ti biological_process owl:Class
GO:0071089 biolink:NamedThing alphaV-beta3 integrin-tissue transglutaminase complex A protein complex that consists of an alphaV-beta3 integrin complex bound to tissue transglutaminase. got7fsn_ti ITGAV-ITGB3-TGM2 complex mah 2009-11-06T04:46:02Z cellular_component owl:Class
GO:0038101 biolink:NamedThing sequestering of nodal from receptor via nodal binding Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor. got7fsn_ti extracellular regulation of nodal|nodal antagonist activity|binding to and sequestering nodal bf 2012-02-17T11:21:22Z biological_process owl:Class
GO:1900108 biolink:NamedThing negative regulation of nodal signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of nodal signaling pathway. got7fsn_ti down regulation of nodal signaling pathway|down regulation of nodal signaling|negative regulation of nodal signalling pathway|downregulation of nodal signaling|down-regulation of nodal signaling pathway|inhibition of nodal signaling|downregulation of nodal signaling pathway|negative regulation of nodal signaling|down-regulation of nodal signaling|inhibition of nodal signaling pathway bf 2012-02-16T03:34:23Z biological_process owl:Class
GO:0072175 biolink:NamedThing epithelial tube formation The developmental process pertaining to the initial formation of an epithelial tube. got7fsn_ti mah 2010-02-26T02:15:40Z biological_process owl:Class
GO:0070929 biolink:NamedThing trans-translation A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes. got7fsn_ti mah 2009-09-16T04:06:12Z biological_process owl:Class
GO:0097539 biolink:NamedThing ciliary transition fiber A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium). got7fsn_ti distal appendage of centriole|transition fibre|cilial transition fiber|cilial transition fibre|cilium transition fibre|transition fiber|centriolar distal appendage|distal appendage of basal body|ciliary transition fibre|cilium transition fiber|distal appendage of mother centriole In mammals, ciliary transition fibers comprise at least five components (Ccdc41/Cep83, Cep89/Cep123, Sclt1, Fbf1, and Cep164) (PMID:24469809). pr 2013-12-03T16:46:37Z cellular_component owl:Class
GO:0042704 biolink:NamedThing uterine wall breakdown The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels. got7fsn_ti biological_process owl:Class
GO:0042703 biolink:NamedThing menstruation The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Menstruation biological_process owl:Class
GO:0002114 biolink:NamedThing interleukin-33 receptor activity Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-33 receptor activity|IL-33R molecular_function owl:Class
GO:0002113 biolink:NamedThing interleukin-33 binding Binding to interleukin-33. got7fsn_ti IL-33 binding molecular_function owl:Class
GO:0002801 biolink:NamedThing negative regulation of antifungal peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion. got7fsn_ti inhibition of antifungal peptide secretion|downregulation of antifungal peptide secretion|down-regulation of antifungal peptide secretion|down regulation of antifungal peptide secretion biological_process owl:Class
GO:0048900 biolink:NamedThing anterior lateral line neuromast primordium migration The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop. got7fsn_ti ALL neuromast primordium migration biological_process owl:Class
GO:0048899 biolink:NamedThing anterior lateral line development The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear. got7fsn_ti anterior LL development biological_process owl:Class
GO:0060913 biolink:NamedThing cardiac cell fate determination The process involved in cardiac cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. got7fsn_ti cardiocyte cell fate determination dph 2009-09-17T08:55:29Z biological_process owl:Class
GO:0044091 biolink:NamedThing membrane biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. got7fsn_ti biological_process owl:Class
GO:0086024 biolink:NamedThing adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate. got7fsn_ti adrenergic receptor signalling pathway involved in positive regulation of heart rate|activation of funny current by beta-adrenergic receptor signaling pathway|beta adrenergic receptor signaling pathway involved in positive regulation of heart rate|adrenergic receptor signaling pathway involved in positive regulation of heart rate|Gs-coupled adrenergic receptor signaling pathway involved in positive regulation of heart rate|If activation by beta-adrenergic receptor signaling pathway|adenylate cyclase-activating cardiac adrenergic receptor signaling pathway tb 2011-11-10T09:38:49Z biological_process owl:Class
GO:0086010 biolink:NamedThing membrane depolarization during action potential The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti tb 2011-11-10T08:15:05Z biological_process owl:Class
GO:0090331 biolink:NamedThing negative regulation of platelet aggregation Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. got7fsn_ti platelet disaggregation tb 2010-05-14T10:46:08Z biological_process owl:Class
GO:0030073 biolink:NamedThing insulin secretion The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. got7fsn_ti https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045 biological_process owl:Class
GO:0007426 biolink:NamedThing tracheal outgrowth, open tracheal system The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0099527 biolink:NamedThing postsynapse to nucleus signaling pathway A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). got7fsn_ti postsynaptic signaling to nucleus biological_process owl:Class
GO:1903751 biolink:NamedThing negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. got7fsn_ti downregulation of H2O2-induced intrinsic apoptotic signaling pathway|inhibition of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|down-regulation of intrinsic apoptotic signaling pathway in response to H2O2|inhibition of intrinsic apoptotic signaling pathway in response to H2O2|downregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|negative regulation of H2O2-induced intrinsic apoptotic signaling pathway|down regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|downregulation of intrinsic apoptotic signaling pathway in response to H2O2|down regulation of H2O2-induced intrinsic apoptotic signaling pathway|inhibition of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|down regulation of intrinsic apoptotic signaling pathway in response to H2O2|negative regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|down-regulation of H2O2-induced intrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to H2O2|inhibition of H2O2-induced intrinsic apoptotic signaling pathway|downregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|down regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|down-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|down-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway krc 2014-12-12T23:04:37Z biological_process owl:Class
GO:0072274 biolink:NamedThing metanephric glomerular basement membrane development The process whose specific outcome is the progression of the metanephric glomerular basement membrane over time, from its formation to the mature structure. The metanephric glomerular basement membrane is the basal laminal portion of the metanephric glomerulus which performs the actual filtration. got7fsn_ti mah 2010-04-01T02:43:51Z biological_process owl:Class
GO:0046597 biolink:NamedThing negative regulation of viral entry into host cell Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell. got7fsn_ti negative regulation of viral penetration into host cell biological_process owl:Class
GO:0035992 biolink:NamedThing tendon formation The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts. got7fsn_ti bf 2011-08-30T01:35:10Z biological_process owl:Class
GO:0050764 biolink:NamedThing regulation of phagocytosis Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material. got7fsn_ti biological_process owl:Class
GO:0044223 biolink:NamedThing pirellulosome A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm. got7fsn_ti jl 2009-11-12T04:08:07Z cellular_component owl:Class
GO:0086036 biolink:NamedThing regulation of cardiac muscle cell membrane potential Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti tb 2011-11-11T03:23:36Z biological_process owl:Class
GO:0007405 biolink:NamedThing neuroblast proliferation The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron. got7fsn_ti GO:0043349|GO:0043350 biological_process owl:Class
GO:0071281 biolink:NamedThing cellular response to iron ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. got7fsn_ti cellular response to iron mah 2009-12-10T03:57:22Z biological_process owl:Class
GO:0050577 biolink:NamedThing GDP-L-fucose synthase activity Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+. got7fsn_ti GDP-fucose synthetase activity|GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase activity|GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Reactome:R-HSA-6787642|MetaCyc:1.1.1.271-RXN|RHEA:18885|EC:1.1.1.271 molecular_function owl:Class
GO:2001284 biolink:NamedThing regulation of BMP secretion Any process that modulates the frequency, rate or extent of BMP secretion. got7fsn_ti regulation of BMP protein secretion|regulation of bone morphogenetic protein secretion bf 2011-12-15T02:15:28Z biological_process owl:Class
GO:0032203 biolink:NamedThing telomere formation via telomerase A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme. got7fsn_ti biological_process owl:Class
GO:1905324 biolink:NamedThing telomere-telomerase complex assembly The aggregation, arrangement and bonding together of a set of components to form a telomere-telomerase complex. got7fsn_ti telomere-telomerase complex formation mah 2016-07-18T10:38:22Z biological_process owl:Class
GO:0061349 biolink:NamedThing planar cell polarity pathway involved in cardiac right atrium morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac right atrium. got7fsn_ti dph 2010-10-01T10:52:01Z biological_process owl:Class
GO:0003213 biolink:NamedThing cardiac right atrium morphogenesis The process in which the right cardiac atrium is generated and organized. got7fsn_ti dph 2009-10-13T09:49:03Z biological_process owl:Class
GO:0072226 biolink:NamedThing metanephric long descending thin limb bend development The process whose specific outcome is the progression of the metanephric long descending thin limb bend over time, from its formation to the mature structure. The metanephric long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment in the metanephros. got7fsn_ti mah 2010-03-18T03:37:16Z biological_process owl:Class
GO:0019823 biolink:NamedThing P5 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content. got7fsn_ti peroxisome vesicle Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'. cellular_component owl:Class
GO:0043674 biolink:NamedThing columella A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella). got7fsn_ti sexine 1 cellular_component owl:Class
GO:0035195 biolink:NamedThing gene silencing by miRNA Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. got7fsn_ti gene silencing by microRNA|miRNA-mediated gene silencing|microRNA-mediated gene silencing biological_process owl:Class
GO:0021763 biolink:NamedThing subthalamic nucleus development The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function. got7fsn_ti corpus luysi development biological_process owl:Class
GO:0021539 biolink:NamedThing subthalamus development The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis. got7fsn_ti ventral thalamus development biological_process owl:Class
GO:2000809 biolink:NamedThing positive regulation of synaptic vesicle clustering Any process that activates or increases the frequency, rate or extent of synaptic vesicle clustering. got7fsn_ti pr 2011-07-06T09:50:37Z biological_process owl:Class
GO:0002493 biolink:NamedThing lipid antigen assembly with MHC class Ib protein complex The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family. got7fsn_ti biological_process owl:Class
GO:0080110 biolink:NamedThing sporopollenin biosynthetic process The chemical reactions and pathways resulting in the formation of sporopollenin, a primary constituent of the pollen exine layer. got7fsn_ti sporopollenin biosynthesis dhl 2009-04-23T04:44:16Z biological_process owl:Class
GO:1900277 biolink:NamedThing negative regulation of proteinase activated receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of proteinase activated receptor activity. got7fsn_ti down regulation of proteinase activated receptor activity|downregulation of proteinase activated receptor activity|inhibition of proteinase activated receptor activity|down-regulation of proteinase activated receptor activity rl 2012-04-04T01:31:29Z biological_process owl:Class
GO:0003422 biolink:NamedThing growth plate cartilage morphogenesis The process in which the anatomical structures of growth plate cartilage are generated and organized. got7fsn_ti dph 2009-12-22T09:21:30Z biological_process owl:Class
GO:0034101 biolink:NamedThing erythrocyte homeostasis Any process of regulating the production and elimination of erythrocytes within an organism. got7fsn_ti RBC homeostasis|red blood cell homeostasis biological_process owl:Class
GO:0080128 biolink:NamedThing anther septum development The process whose specific outcome is the progression of the anther septum over time, from its formation to the mature structure. The anther septum is a thin partition or stretch of cells that are present in the anther dehiscence zone. got7fsn_ti dhl 2009-04-28T04:41:16Z biological_process owl:Class
GO:0042957 biolink:NamedThing dextrin transmembrane transporter activity Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042955 biolink:NamedThing dextrin transport The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0061090 biolink:NamedThing positive regulation of sequestering of zinc ion Any process that increases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. got7fsn_ti dph 2010-04-26T01:38:53Z biological_process owl:Class
GO:0033232 biolink:NamedThing ABC-type D-methionine transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out/in) = ADP + phosphate + D-methionine(in/out). got7fsn_ti ATPase-coupled D-methionine transporter activity|ATP-dependent methionine transmembrane transporter activity|D-methionine transmembrane transporter activity|ATPase-coupled methionine transmembrane transporter activity|D-methionine importer|methionine transmembrane-transporting ATPase activity|D-methionine exporter|D-methionine-exporting ATPase activity|D-methionine-importing ATPase activity|D-methionine-transporting ATPase activity|ATP-dependent D-methionine transporter activity|D-methionine transporter activity jl 2012-08-07T15:59:50Z GO:1901243|GO:0032521|GO:0032522|GO:0048474 EC:7.4.2.11|RHEA:29779 molecular_function owl:Class
GO:0048473 biolink:NamedThing D-methionine transport The directed movement of D-methionine into, out of, within, or between cells. got7fsn_ti biological_process owl:Class
GO:0061669 biolink:NamedThing spontaneous neurotransmitter secretion Neurotransmitter secretion that occurs in the absence of the action of a secretagogue or a presynaptic action potential. got7fsn_ti stimulus-independent neurotransmitter secretion dph 2014-11-17T07:52:35Z biological_process owl:Class
GO:0048213 biolink:NamedThing Golgi vesicle prefusion complex stabilization The binding of specific proteins to the t-SNARE/v-SNARE/SNAP25 complex, by which the Golgi vesicle prefusion complex is stabilized. got7fsn_ti Golgi-derived vesicle prefusion complex stabilization|Golgi vesicle prefusion complex assembly|dictyosome vesicle prefusion complex stabilisation biological_process owl:Class
GO:0097398 biolink:NamedThing cellular response to interleukin-17 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus. got7fsn_ti cellular response to IL-17 pr 2012-10-23T13:25:43Z biological_process owl:Class
GO:0099560 biolink:NamedThing synaptic membrane adhesion The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. got7fsn_ti synapse adhesion between pre- and post-synapse biological_process owl:Class
GO:0048852 biolink:NamedThing diencephalon morphogenesis The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex. got7fsn_ti biological_process owl:Class
GO:0048853 biolink:NamedThing forebrain morphogenesis The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions). got7fsn_ti prosencephalon morphogenesis biological_process owl:Class
GO:0035493 biolink:NamedThing SNARE complex assembly The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. got7fsn_ti bf 2010-04-26T02:50:52Z biological_process owl:Class
GO:0001963 biolink:NamedThing synaptic transmission, dopaminergic The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. got7fsn_ti dopaminergic synaptic transmission biological_process owl:Class
CL:0000700 biolink:NamedThing got7fsn_ti owl:Class
GO:0006144 biolink:NamedThing purine nucleobase metabolic process The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. got7fsn_ti purine metabolism|purine base metabolism|purine metabolic process|purine base metabolic process biological_process owl:Class
GO:0043999 biolink:NamedThing histone acetyltransferase activity (H2A-K5 specific) Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5). got7fsn_ti histone lysine N-acetyltransferase activity (H2A-K5 specific) molecular_function owl:Class
GO:0043977 biolink:NamedThing histone H2A-K5 acetylation The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone. got7fsn_ti histone H2A acetylation at K5 biological_process owl:Class
GO:0007493 biolink:NamedThing endodermal cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti endoderm cell fate determination Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'. biological_process owl:Class
GO:0043508 biolink:NamedThing negative regulation of JUN kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. got7fsn_ti negative regulation of JUNK activity|downregulation of JNK activity|down regulation of JNK activity|down-regulation of JNK activity|inhibition of JNK activity biological_process owl:Class
GO:0007254 biolink:NamedThing JNK cascade An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. got7fsn_ti MAPK9 cascade|JNK1 cascade|MAPK10 cascade|MAPK8 cascade|stress-activated protein kinase cascade|JNK2 cascade|SAPK cascade|JNK3 cascade|c-Jun N-terminal kinase cascade biological_process owl:Class
GO:0048821 biolink:NamedThing erythrocyte development The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure. got7fsn_ti RBC development|red blood cell development biological_process owl:Class
GO:0010016 biolink:NamedThing shoot system morphogenesis The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground. got7fsn_ti shoot morphogenesis biological_process owl:Class
GO:0012508 biolink:NamedThing Golgi to ER transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER. got7fsn_ti Golgi-ER transport vesicle membrane|Golgi to endoplasmic reticulum transport vesicle membrane|Golgi to ER constitutive secretory pathway transport vesicle membrane|Golgi-endoplasmic reticulum transport vesicle membrane cellular_component owl:Class
GO:2001208 biolink:NamedThing negative regulation of transcription elongation by RNA polymerase I Any process that stops, prevents or reduces the frequency, rate or extent of transcription elongation mediated by RNA polymerase I. got7fsn_ti negative regulation of transcription elongation from RNA polymerase I promoter|negative regulation of RNA elongation from Pol I promoter se 2011-11-11T10:46:36Z biological_process owl:Class
GO:1904341 biolink:NamedThing regulation of colon smooth muscle contraction Any process that modulates the frequency, rate or extent of colon smooth muscle contraction. got7fsn_ti sl 2015-06-11T21:16:58Z biological_process owl:Class
GO:0021598 biolink:NamedThing abducens nerve morphogenesis The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. got7fsn_ti CN VI development biological_process owl:Class
GO:0044603 biolink:NamedThing protein adenylylhydrolase activity Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins. got7fsn_ti protein deAMPylation activity|protein deAMPylase activity jl 2012-05-01T04:18:07Z molecular_function owl:Class
GO:0030906 biolink:NamedThing retromer, cargo-selective complex The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals. got7fsn_ti retromer, cargo recognition complex|cargo-selective retromer subcomplex|retromer, CRC|retromer CSC|retromer complex, inner shell cellular_component owl:Class
GO:0015485 biolink:NamedThing cholesterol binding Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. got7fsn_ti molecular_function owl:Class
GO:0061325 biolink:NamedThing cell proliferation involved in outflow tract morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract. got7fsn_ti dph 2010-09-28T09:29:30Z biological_process owl:Class
GO:0070892 biolink:NamedThing lipoteichoic acid immune receptor activity Combining with lipoteichoic acid and transmitting the signal to initiate an innate immune response. got7fsn_ti lipoteichoic acid receptor activity mah 2009-09-01T02:59:24Z molecular_function owl:Class
GO:0070891 biolink:NamedThing lipoteichoic acid binding Binding to lipoteichoic acid. got7fsn_ti mah 2009-09-01T02:56:36Z molecular_function owl:Class
GO:0072039 biolink:NamedThing regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. got7fsn_ti regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis|regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis mah 2010-01-25T03:08:34Z biological_process owl:Class
GO:0016593 biolink:NamedThing Cdc73/Paf1 complex A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. got7fsn_ti Paf1 complex|Paf1p complex cellular_component owl:Class
GO:0032339 biolink:NamedThing negative regulation of inhibin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell. got7fsn_ti down regulation of inhibin secretion|downregulation of inhibin secretion|inhibition of inhibin secretion|down-regulation of inhibin secretion biological_process owl:Class
GO:0030490 biolink:NamedThing maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. got7fsn_ti processing of 20S pre-rRNA|SSU-rRNA maturation biological_process owl:Class
GO:0005344 biolink:NamedThing oxygen carrier activity Binding to oxygen and delivering it to an acceptor molecule or a specific location. got7fsn_ti oxygen-carrying|hemocyanin|hemerythrin|globin https://github.com/geneontology/go-ontology/issues/17399 GO:0015033 molecular_function owl:Class
GO:0015671 biolink:NamedThing oxygen transport The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0048826 biolink:NamedThing cotyledon morphogenesis The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. got7fsn_ti biological_process owl:Class
GO:0048825 biolink:NamedThing cotyledon development The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling. got7fsn_ti biological_process owl:Class
GO:0021897 biolink:NamedThing forebrain astrocyte development The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function. got7fsn_ti biological_process owl:Class
GO:0001744 biolink:NamedThing insect visual primordium formation Establishment of the optic lobe placode. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system. got7fsn_ti optic lobe and Bolwig's organ precursor formation|optic lobe placode formation GO:0007457 biological_process owl:Class
GO:0001748 biolink:NamedThing insect visual primordium development The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster. got7fsn_ti optic lobe and Bolwig's organ precursor development|optic lobe placode development|optic placode development GO:0048049 biological_process owl:Class
GO:0009034 biolink:NamedThing tryptophanase activity Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate. got7fsn_ti tryptophan catabolism, using tryptophanase|L-tryptophan indole-lyase (deaminating) activity|tryptophan catabolic process, using tryptophanase|TNase activity|L-tryptophanase activity|L-tryptophan indole-lyase activity|L-tryptophan indole-lyase (deaminating; pyruvate forming) activity Note that this term has a MetaCyc pathway reference as the pathway only has a single step. RHEA:19553|MetaCyc:TRYPDEG-PWY|MetaCyc:TRYPTOPHAN-RXN|EC:4.1.99.1|KEGG_REACTION:R00673|UniPathway:UPA00332 molecular_function owl:Class
GO:0006569 biolink:NamedThing tryptophan catabolic process The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. got7fsn_ti tryptophan catabolic process, using tryptophanase|tryptophan catabolism|tryptophan degradation|tryptophan breakdown|tryptophan catabolism, using tryptophanase biological_process owl:Class
GO:0035722 biolink:NamedThing interleukin-12-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-12-mediated signaling pathway|interleukin-12-mediated signalling pathway bf 2011-03-07T11:27:58Z biological_process owl:Class
GO:1990659 biolink:NamedThing sequestering of manganese ion The process of binding or confining manganese ions such that they are separated from other components of a biological system. got7fsn_ti manganese ion sequestering|manganese ion retention|storage of manganese ion|manganese ion storage|manganese ion sequestration|retention of manganese ion|sequestration of manganese ion An example of this is S100A9 in human (UniProt symbol P06702) in PMID:25417112 (inferred from direct assay). bhm 2015-02-25T11:41:12Z biological_process owl:Class
GO:0072580 biolink:NamedThing bacterial-type EF-P lysine modification The modification of a lysine residue in a protein to produce (2S)-2-amino-6-([(3S)-3,6-diaminohexanoyl]amino)hexanoic acid, and the subsequent hydroxylation of the modified lysine residue. This modification is observed in, and is probably unique to, the prokaryotic translation elongation factor P (EF-P). got7fsn_ti EF-P modification pathway The EF-P modification pathway is now thought to be composed of three steps: conversion of alpha-lysyl-EF-P to beta-lysyl-EF-P, lysylation of Lys34, and hydroxylation of Lys34. mah 2011-02-07T11:47:33Z biological_process owl:Class
GO:1900438 biolink:NamedThing negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. got7fsn_ti inhibition of filamentous growth of a population of unicellular organisms in response to chemical stimulus|downregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|down regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|down-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus di 2012-04-25T05:55:26Z biological_process owl:Class
GO:1901076 biolink:NamedThing positive regulation of engulfment of apoptotic cell Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell. got7fsn_ti up-regulation of engulfment of apoptotic cell corpse|up-regulation of engulfment of cell corpse|activation of engulfment of apoptotic cell corpse|upregulation of engulfment of cell corpse|activation of engulfment of cell corpse|activation of engulfment of apoptotic cell|upregulation of engulfment of apoptotic cell corpse|up-regulation of engulfment of apoptotic cell|up regulation of engulfment of apoptotic cell corpse|up regulation of engulfment of apoptotic cell|positive regulation of engulfment of cell corpse|positive regulation of engulfment of apoptotic cell corpse|upregulation of engulfment of apoptotic cell|up regulation of engulfment of cell corpse kmv 2012-07-02T07:32:51Z biological_process owl:Class
GO:0043277 biolink:NamedThing apoptotic cell clearance The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. got7fsn_ti programmed cell clearance|apoptotic cell removal|efferocytosis Note that unlike mammals or Drosophila, C. elegans (and many lower organisms) do not have professional macrophages/phagocytes, instead cell corpses are engulfed by neighboring cells. Cell types that can function as engulfing cells include hypodermal cells, gonadal sheath cells, pharyngeal muscle cells, and intestinal cells. biological_process owl:Class
GO:0030938 biolink:NamedThing collagen type XVIII trimer A collagen homotrimer of alpha1(XVIII) chains. got7fsn_ti cellular_component owl:Class
GO:0055104 biolink:NamedThing ligase inhibitor activity Binds to and stops, prevents or reduces the activity of a ligase. got7fsn_ti molecular_function owl:Class
GO:1905520 biolink:NamedThing positive regulation of presynaptic active zone assembly Any process that activates or increases the frequency, rate or extent of presynaptic active zone assembly. got7fsn_ti upregulation of presynaptic active zone assembly|up regulation of pre-synaptic active zone assembly|positive regulation of pre-synaptic active zone formation|positive regulation of presynaptic active zone formation|positive regulation of pre-synaptic active zone assembly|up-regulation of pre-synaptic active zone assembly|activation of pre-synaptic active zone component assembly|upregulation of pre-synaptic active zone formation|up-regulation of pre-synaptic active zone component assembly|up-regulation of presynaptic active zone assembly|positive regulation of pre-synaptic active zone component assembly|up-regulation of pre-synaptic active zone formation|up regulation of pre-synaptic active zone component formation|activation of pre-synaptic active zone assembly|up regulation of pre-synaptic active zone component assembly|up-regulation of pre-synaptic active zone component formation|upregulation of pre-synaptic active zone assembly|upregulation of pre-synaptic active zone component assembly|activation of pre-synaptic active zone component formation|up-regulation of presynaptic active zone formation|up regulation of presynaptic active zone assembly|up regulation of pre-synaptic active zone formation|upregulation of presynaptic active zone formation|up regulation of presynaptic active zone formation|upregulation of pre-synaptic active zone component formation|activation of presynaptic active zone formation|activation of pre-synaptic active zone formation|positive regulation of pre-synaptic active zone component formation|activation of presynaptic active zone assembly rl 2016-10-01T09:38:07Z biological_process owl:Class
GO:0016503 biolink:NamedThing pheromone receptor activity Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior. got7fsn_ti molecular_function owl:Class
GO:0019912 biolink:NamedThing cyclin-dependent protein kinase activating kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK). got7fsn_ti CAK|cdk-activating kinase activity|cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity GO:0019913 molecular_function owl:Class
GO:0035919 biolink:NamedThing negative regulation of low voltage-gated calcium channel activity in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. got7fsn_ti down-regulation of low voltage-gated calcium channel activity in other organism|inhibition of low voltage-gated calcium channel activity in other organism|negative regulation of low voltage gated calcium channel activity in other organism|downregulation of low voltage-gated calcium channel activity in other organism|negative regulation of low voltage-dependent calcium channel activity in other organism bf 2011-07-01T11:56:21Z biological_process owl:Class
GO:0001649 biolink:NamedThing osteoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. got7fsn_ti osteoblast cell differentiation biological_process owl:Class
GO:1905137 biolink:NamedThing regulation of viral DNA genome packaging via site-specific sequence recognition Any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition. got7fsn_ti pr 2016-04-13T11:37:13Z biological_process owl:Class
GO:0003391 biolink:NamedThing amphid sensory organ dendrite retrograde extension The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point. got7fsn_ti dph 2009-12-09T09:28:27Z biological_process owl:Class
GO:0070309 biolink:NamedThing lens fiber cell morphogenesis The process in which the structures of a lens fiber cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. got7fsn_ti lens fiber cell morphogenesis during differentiation|elongation of lens fiber cell|lens fibre cell morphogenesis biological_process owl:Class
GO:0070307 biolink:NamedThing lens fiber cell development The process whose specific outcome is the progression of a lens fiber cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a lens fiber cell fate. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. got7fsn_ti lens fibre cell development biological_process owl:Class
GO:0043559 biolink:NamedThing insulin binding Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. got7fsn_ti molecular_function owl:Class
GO:0043710 biolink:NamedThing cell adhesion involved in multi-species biofilm formation The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species. got7fsn_ti cell adhesion during multi-species biofilm formation biological_process owl:Class
GO:0044399 biolink:NamedThing multi-species biofilm formation A process in which planktonically growing microorganisms of different species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. got7fsn_ti multi-species surface biofilm formation|multi-species biofilm formation in or on host organism|multi-species biofilm formation on inanimate substrate|multi-species submerged biofilm formation GO:0044401|GO:0090608|GO:0090607|GO:0044400 biological_process owl:Class
GO:0048914 biolink:NamedThing myelination of anterior lateral line nerve axons The formation of compact myelin sheaths around the axons of the anterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0048940 biolink:NamedThing anterior lateral line nerve glial cell morphogenesis involved in differentiation The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0051474 biolink:NamedThing glucosylglycerol transmembrane transporter activity Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. got7fsn_ti molecular_function owl:Class
GO:0051475 biolink:NamedThing glucosylglycerol transport The directed movement of glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0060335 biolink:NamedThing positive regulation of interferon-gamma-mediated signaling pathway Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor. got7fsn_ti positive regulation of interferon-gamma-mediated signalling pathway|positive regulation of gamma-interferon-mediated signaling pathway|positive regulation of type II IFN-mediated pathway|positive regulation of type II interferon-mediated signaling pathway|positive regulation of immune interferon-mediated signaling pathway biological_process owl:Class
GO:0034341 biolink:NamedThing response to interferon-gamma Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon. got7fsn_ti response to type II IFN|response to immune interferon|response to type II interferon|response to gamma-interferon biological_process owl:Class
GO:0097445 biolink:NamedThing presynaptic active zone dense projection Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered. got7fsn_ti active zone dense projection|pre-synaptic active zone dense projection pr 2012-12-06T14:08:21Z NIF_Subcellular:sao494258938 cellular_component owl:Class
GO:0020018 biolink:NamedThing ciliary pocket membrane That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket). got7fsn_ti cilium pocket membrane|flagellar pocket membrane|cilial pocket membrane Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage. cellular_component owl:Class
GO:0020016 biolink:NamedThing ciliary pocket Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes. got7fsn_ti cilial pocket|flagellar pocket|cilium pocket Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage. cellular_component owl:Class
GO:0009574 biolink:NamedThing preprophase band A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs. got7fsn_ti Wikipedia:Preprophase_band cellular_component owl:Class
GO:0030486 biolink:NamedThing smooth muscle dense body Electron-dense region associated with a smooth muscle contractile fiber. got7fsn_ti cellular_component owl:Class
GO:0030485 biolink:NamedThing smooth muscle contractile fiber The contractile fiber of smooth muscle cells. got7fsn_ti cellular_component owl:Class
GO:0061989 biolink:NamedThing sperm karyosome formation The chromosome organization process in which meiotic chromosomes in the spem nucleus cluster together to form a compact spherical structure called the karyosome. got7fsn_ti dph 2018-02-15T21:29:47Z biological_process owl:Class
GO:1903668 biolink:NamedThing negative regulation of chemorepellent activity Any process that stops, prevents or reduces the frequency, rate or extent of chemorepellent activity. got7fsn_ti inhibition of chemorepellent activity|negative regulation of chemorepellant activity|down regulation of chemorepellant activity|down-regulation of chemorepellent activity|down-regulation of chemorepellant activity|inhibition of chemorepellant activity|downregulation of chemorepellent activity|downregulation of chemorepellant activity|down regulation of chemorepellent activity pf 2014-11-26T23:58:42Z biological_process owl:Class
GO:0045479 biolink:NamedThing vesicle targeting to fusome The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome. got7fsn_ti vesicle-fusome targeting biological_process owl:Class
GO:0061537 biolink:NamedThing glycine secretion, neurotransmission The controlled release of glycine by a cell, in which glycine acts as a neurotransmitter. got7fsn_ti dph 2013-06-21T16:19:02Z biological_process owl:Class
GO:0080156 biolink:NamedThing mitochondrial mRNA modification The covalent alteration within the mitochondrion of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically. got7fsn_ti mitochondrial mRNA editing|mitochondrial RNA editing dhl 2010-09-01T03:55:48Z biological_process owl:Class
GO:1990162 biolink:NamedThing histone deacetylase activity (H3-K4 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein. got7fsn_ti pr 2013-08-06T08:48:44Z molecular_function owl:Class
GO:1990596 biolink:NamedThing histone H3-K4 deacetylation The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone. got7fsn_ti al 2014-12-23T19:37:15Z biological_process owl:Class
GO:1902734 biolink:NamedThing regulation of receptor-mediated virion attachment to host cell Any process that modulates the frequency, rate or extent of receptor-mediated virion attachment to host cell. got7fsn_ti regulation of virion attachment, binding of host cell surface receptor als 2014-02-25T12:25:56Z biological_process owl:Class
GO:0046710 biolink:NamedThing GDP metabolic process The chemical reactions and pathways involving GDP, guanosine 5'-diphosphate. got7fsn_ti GDP metabolism biological_process owl:Class
GO:0021889 biolink:NamedThing olfactory bulb interneuron differentiation The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb. got7fsn_ti biological_process owl:Class
GO:0048906 biolink:NamedThing anterior lateral line neuromast support cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. got7fsn_ti biological_process owl:Class
GO:0048901 biolink:NamedThing anterior lateral line neuromast development The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals. got7fsn_ti biological_process owl:Class
GO:0072186 biolink:NamedThing metanephric cap morphogenesis The process in which the anatomical structures of the metanephric cap are generated and organized. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. got7fsn_ti mah 2010-03-01T01:22:51Z biological_process owl:Class
GO:0048223 biolink:NamedThing hemicellulose network Network composed of hemicelluloses; members of a class of plant cell wall polysaccharide that cannot be extracted from the wall by hot water or chelating agents, but can be extracted by aqueous alkali. Includes xylan, glucuronoxylan, arabinoxylan, arabinogalactan II, glucomannan, xyloglucan and galactomannan. got7fsn_ti cellular_component owl:Class
GO:0034402 biolink:NamedThing recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex The process in which proteins required for 3'-end transcript processing become associated with the RNA polymerase II holoenzyme complex and the 3' end of a transcript. got7fsn_ti biological_process owl:Class
GO:0009319 biolink:NamedThing cytochrome o ubiquinol oxidase complex A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups. got7fsn_ti See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'. MetaCyc:CYT-O-UBIOX-CPLX cellular_component owl:Class
GO:1990513 biolink:NamedThing CLOCK-BMAL transcription complex Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms. got7fsn_ti CLOCK/BMAL complex An example of this is CLOCK in human (O15516) in PMID:23229515 (inferred from physical interaction). bhm 2014-10-08T13:10:24Z cellular_component owl:Class
GO:0015207 biolink:NamedThing adenine transmembrane transporter activity Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. got7fsn_ti Reactome:R-HSA-5672027|RHEA:34999|Reactome:R-HSA-163215 molecular_function owl:Class
GO:0015853 biolink:NamedThing adenine transport The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti adenine transmembrane transport biological_process owl:Class
GO:0044312 biolink:NamedThing crystalloid A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation. got7fsn_ti jl 2010-02-18T03:58:55Z cellular_component owl:Class
GO:1901630 biolink:NamedThing negative regulation of presynaptic membrane organization Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic membrane organization. got7fsn_ti down regulation of presynaptic membrane organization|inhibition of presynaptic membrane organization|negative regulation of pre-synaptic membrane organization|downregulation of presynaptic membrane organization|down-regulation of presynaptic membrane organisation|down regulation of presynaptic membrane organisation|down-regulation of presynaptic membrane organization|downregulation of presynaptic membrane organisation|inhibition of presynaptic membrane organisation|negative regulation of presynaptic membrane organisation ans 2012-11-15T11:40:36Z biological_process owl:Class
GO:0045497 biolink:NamedThing female analia development The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0071254 biolink:NamedThing cytoplasmic U snRNP body A ribonucleoprotein complex that can be visualized as a focus in the cytoplasm, and contains uridine-rich small nuclear ribonucleoproteins (U snRNPs) and essential snRNP assembly factors. These U bodies are invariably found in association with P bodies. got7fsn_ti U body|U-body mah 2009-12-04T10:31:29Z cellular_component owl:Class
GO:0001547 biolink:NamedThing antral ovarian follicle growth Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity. got7fsn_ti biological_process owl:Class
GO:0080157 biolink:NamedThing regulation of plant-type cell wall organization or biogenesis Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving plant-type cell wall organization or biogenesis. Plant-type cell wall organization or biogenesis is a process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellulose- and pectin-containing cell wall. got7fsn_ti regulation of plant-type cell wall organisation or biogenesis dhl 2010-09-01T04:02:37Z biological_process owl:Class
GO:1904513 biolink:NamedThing negative regulation of initiation of premeiotic DNA replication Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication. got7fsn_ti down regulation of initiation of premeiotic DNA replication|down-regulation of initiation of premeiotic DNA synthesis|down regulation of premeiotic DNA replication initiation|negative regulation of meiotic DNA replication initiation|downregulation of initiation of premeiotic DNA replication|down-regulation of initiation of premeiotic DNA replication|down regulation of meiotic DNA replication initiation|inhibition of initiation of premeiotic DNA synthesis|inhibition of initiation of meiotic DNA synthesis|down-regulation of premeiotic DNA replication initiation|inhibition of meiotic DNA replication initiation|down-regulation of initiation of meiotic DNA synthesis|downregulation of meiotic DNA replication initiation|downregulation of premeiotic DNA replication initiation|negative regulation of premeiotic DNA replication initiation|down regulation of initiation of premeiotic DNA synthesis|down regulation of initiation of meiotic DNA synthesis|inhibition of premeiotic DNA replication initiation|down-regulation of meiotic DNA replication initiation|downregulation of initiation of meiotic DNA synthesis|negative regulation of initiation of meiotic DNA synthesis|inhibition of initiation of premeiotic DNA replication|downregulation of initiation of premeiotic DNA synthesis|negative regulation of initiation of premeiotic DNA synthesis mah 2015-07-28T12:59:23Z biological_process owl:Class
GO:0039692 biolink:NamedThing single stranded viral RNA replication via double stranded DNA intermediate A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II. got7fsn_ti viral ssRNA replication via dsDNA intermediate|retroviral genome replication bf 2013-10-17T15:59:43Z GO:0045090 VZ:1937 biological_process owl:Class
GO:0039695 biolink:NamedThing DNA-templated viral transcription A transcription process that uses a viral DNA as a template. got7fsn_ti bf 2013-10-28T13:25:20Z VZ:1942 biological_process owl:Class
GO:0061224 biolink:NamedThing mesonephric glomerulus development The progression of the mesonephric glomerulus over time from its initial formation until its mature state. The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros. got7fsn_ti dph 2010-08-19T01:26:00Z biological_process owl:Class
GO:0036126 biolink:NamedThing sperm flagellum A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid. got7fsn_ti sperm cilium|sperm tail Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is always 'flagellum', hence the primary term name, but the cilium parentage is deliberate. bf 2012-02-28T02:39:00Z cellular_component owl:Class
GO:0019035 biolink:NamedThing viral integration complex A nucleoprotein complex containing viral genetic material and the viral integrase, required for genome integration into the host's genome. May contain other proteins. got7fsn_ti pre-integration complex|PIC https://github.com/geneontology/go-ontology/issues/19806 Wikipedia:Pre-integration_complex cellular_component owl:Class
GO:0043657 biolink:NamedThing host cell A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19800 cellular_component owl:Class
GO:0010106 biolink:NamedThing cellular response to iron ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions. got7fsn_ti biological_process owl:Class
GO:0021683 biolink:NamedThing cerebellar granular layer morphogenesis The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. got7fsn_ti biological_process owl:Class
GO:0010319 biolink:NamedThing stromule Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types. got7fsn_ti Stroma-filled tubule Wikipedia:Stromule cellular_component owl:Class
GO:0030325 biolink:NamedThing adrenal gland development The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells. got7fsn_ti interrenal gland biological_process owl:Class
GO:0045829 biolink:NamedThing negative regulation of isotype switching Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching. got7fsn_ti negative regulation of class switching|inhibition of isotype switching|negative regulation of isotype switch recombination|down regulation of isotype switching|negative regulation of class switch recombination|downregulation of isotype switching|down-regulation of isotype switching biological_process owl:Class
GO:0030176 biolink:NamedThing integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti ER integral membrane protein|integral to ER membrane|integral to endoplasmic reticulum membrane cellular_component owl:Class
CL:0000096 biolink:NamedThing got7fsn_ti owl:Class
GO:0009348 biolink:NamedThing ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. got7fsn_ti cellular_component owl:Class
GO:0042658 biolink:NamedThing MHC class II protein binding, via antigen binding groove Binding to the antigen binding groove of major histocompatibility complex class II molecules. got7fsn_ti major histocompatibility complex class II protein binding, via antigen binding groove molecular_function owl:Class
GO:0005693 biolink:NamedThing U12 snRNP A ribonucleoprotein complex that contains small nuclear RNA U12, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U12 snRNP, most of which remain associated with the U12 snRNA both while the U12 snRNP is free or assembled into a series of spliceosomal complexes. got7fsn_ti snRNP U12 cellular_component owl:Class
GO:0042896 biolink:NamedThing chloramphenicol transmembrane transporter activity Enables the transfer of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, from one side of a membrane to the other. got7fsn_ti chloramphenicol transporter activity molecular_function owl:Class
GO:0042892 biolink:NamedThing chloramphenicol transmembrane transport The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti chloramphenicol transport biological_process owl:Class
GO:0032123 biolink:NamedThing deep fiber Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm. got7fsn_ti deep fibre cellular_component owl:Class
GO:0031912 biolink:NamedThing oral apparatus Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems. got7fsn_ti Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals. cellular_component owl:Class
GO:0030332 biolink:NamedThing cyclin binding Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. got7fsn_ti molecular_function owl:Class
GO:1990193 biolink:NamedThing BtuCD complex Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer. got7fsn_ti cobalamin transport complex, core subunit|BtuC-BtuD complex|vitamin B12 transport complex, core subunit bhm 2013-09-12T14:58:56Z cellular_component owl:Class
GO:0042937 biolink:NamedThing tripeptide transmembrane transporter activity Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other. got7fsn_ti tripeptide transporter activity molecular_function owl:Class
GO:0042939 biolink:NamedThing tripeptide transport The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0033286 biolink:NamedThing ATPase-coupled ectoine transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ectoine(out/in) = ADP + phosphate + ectoine(in/out). got7fsn_ti ATP-dependent ectoine transmembrane transporter activity|ectoine transmembrane transporter activity|ectoine-transporting ATPase activity GO:0051471 RHEA:32787 molecular_function owl:Class
GO:0051470 biolink:NamedThing ectoine transport The directed movement of ectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a tetrahydropyrimidine commonly synthesized by halophilic bacteria. got7fsn_ti biological_process owl:Class
GO:0003281 biolink:NamedThing ventricular septum development The progression of the ventricular septum over time from its formation to the mature structure. got7fsn_ti septum inferius development|interventricular septum development dph 2009-10-20T10:04:51Z biological_process owl:Class
GO:0045248 biolink:NamedThing cytosolic oxoglutarate dehydrogenase complex A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). got7fsn_ti See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. cellular_component owl:Class
GO:0004849 biolink:NamedThing uridine kinase activity Catalysis of the reaction: ATP + uridine = ADP + UMP. got7fsn_ti uridine-cytidine kinase activity|uridine monophosphokinase activity|uridine kinase reaction|ATP:uridine 5'-phosphotransferase activity|pyrimidine ribonucleoside kinase activity|uridine phosphokinase activity|uridine kinase (phosphorylating) EC:2.7.1.48|MetaCyc:URIDINEKIN-RXN|Reactome:R-HSA-8954327|RHEA:16825 molecular_function owl:Class
GO:0006222 biolink:NamedThing UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. got7fsn_ti UMP synthesis|UMP biosynthesis|UMP formation|UMP anabolism biological_process owl:Class
GO:0021746 biolink:NamedThing solitary nucleus development The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0045268 biolink:NamedThing plasma membrane proton-transporting ATP synthase, catalytic core The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species. got7fsn_ti proton-transporting ATP synthase, catalytic core|hydrogen-transporting ATP synthase, catalytic core cellular_component owl:Class
GO:0014020 biolink:NamedThing primary neural tube formation The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube. got7fsn_ti primary neurulation|primary neural tube morphogenesis biological_process owl:Class
GO:0046817 biolink:NamedThing chemokine receptor antagonist activity Interacts with chemokine receptors to reduce the action of a chemokine. got7fsn_ti molecular_function owl:Class
GO:0070100 biolink:NamedThing negative regulation of chemokine-mediated signaling pathway Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of a chemokine binding to a cell surface receptor. got7fsn_ti negative regulation of chemokine-mediated signalling pathway biological_process owl:Class
GO:0009950 biolink:NamedThing dorsal/ventral axis specification The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. got7fsn_ti dorsal/ventral axis determination|dorsoventral axis specification|dorsal-ventral axis specification biological_process owl:Class
GO:0002927 biolink:NamedThing archaeosine-tRNA biosynthetic process The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs. got7fsn_ti Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine. hjd 2012-01-18T03:06:27Z biological_process owl:Class
GO:0043867 biolink:NamedThing 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine. got7fsn_ti TgtA|archaeal tRNA-guanine transglycosylase activity|archaeosine tRNA-ribosyltransferase activity molecular_function owl:Class
GO:2000240 biolink:NamedThing positive regulation of tRNA export from nucleus Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus. got7fsn_ti positive regulation of tRNA export from cell nucleus|positive regulation of tRNA transport from nucleus to cytoplasm|positive regulation of tRNA-nucleus export|positive regulation of tRNA export out of nucleus mah 2010-11-10T12:39:38Z biological_process owl:Class
GO:0035437 biolink:NamedThing maintenance of protein localization in endoplasmic reticulum Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum. got7fsn_ti maintenance of protein localisation in endoplasmic reticulum|maintenance of protein localization in ER|maintenance of protein location in endoplasmic reticulum|retention of protein in endoplasmic reticulum|maintenance of protein location in ER|protein-endoplasmic reticulum retention|retention of protein in ER|protein-ER retention bf 2010-04-09T10:39:49Z biological_process owl:Class
GO:0046598 biolink:NamedThing positive regulation of viral entry into host cell Any process that activates or increases the frequency, rate or extent of the introduction of viral entry into the host cell. got7fsn_ti positive regulation of viral penetration into host cell biological_process owl:Class
GO:0002625 biolink:NamedThing regulation of T cell antigen processing and presentation Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation. got7fsn_ti regulation of T-lymphocyte antigen processing and presentation|regulation of T-cell antigen processing and presentation|regulation of T lymphocyte antigen processing and presentation biological_process owl:Class
GO:0045509 biolink:NamedThing interleukin-27 receptor activity Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-27R|IL-27 receptor activity molecular_function owl:Class
GO:0070106 biolink:NamedThing interleukin-27-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-27-mediated signalling pathway|IL27RA/IL6ST signaling pathway|IL-27-mediated signaling pathway biological_process owl:Class
GO:0008556 biolink:NamedThing P-type potassium transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). got7fsn_ti potassium ABC transporter|ATP phosphohydrolase (K+-importing)|potassium-importing ATPase activity|K(+)-importing ATPase activity|potassium-uptake-ATPase activity|ATP-dependent potassium transmembrane transporter activity|ATPase-coupled potassium transmembrane transporter activity|K+-importing ATPase activity|potassium-transporting ATPase activity|potassium transmembrane transporter activity, phosphorylative mechanism|potassium transporting ATPase activity|K+-transporting ATPase activity|K(+)-transporting ATPase activity GO:0015618 EC:7.2.2.6|RHEA:16777 molecular_function owl:Class
GO:0003984 biolink:NamedThing acetolactate synthase activity Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. got7fsn_ti acetohydroxy acid synthetase activity|alpha-acetohydroxyacid synthase activity|acetolactic synthetase activity|pyruvate:pyruvate acetaldehydetransferase (decarboxylating)|alpha-acetolactate synthetase activity|acetohydroxyacid synthase activity|alpha-acetohydroxy acid synthetase activity|alpha-acetolactate synthase activity|acetolactate pyruvate-lyase (carboxylating) activity Note that this function was formerly EC:4.1.3.18. MetaCyc:ACETOLACTSYN-RXN|EC:2.2.1.6|RHEA:25249 molecular_function owl:Class
GO:1904378 biolink:NamedThing maintenance of unfolded protein involved in ERAD pathway Maintaining an endoplasmic reticulum (ER) protein in an unfolded, soluble state that contributes to its degradation by the cytoplasmic proteasome. Maintaining ER-resident proteins in an unfolded yet soluble state condition after their retro-translocation favors their turnover by the cytosolic proteasome. got7fsn_ti maintenance of unfolded protein involved in ER-associated degradation pathway|holdase activity|ERAD chaperone-like activity|maintenance of unfolded protein during ERAD|maintenance of unfolded protein involved in endoplasmic reticulum-associated degradation|maintenance of unfolded protein involved in endoplasmic reticulum-associated protein degradation pathway|chaperone holdase activity bf 2015-06-23T09:21:53Z biological_process owl:Class
GO:0031897 biolink:NamedThing Tic complex The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane. got7fsn_ti chloroplast inner membrane translocase complex cellular_component owl:Class
GO:0003236 biolink:NamedThing sinus venosus morphogenesis The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. got7fsn_ti dph 2009-10-13T11:16:52Z biological_process owl:Class
GO:0035182 biolink:NamedThing female germline ring canal outer rim An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues. got7fsn_ti ovarian ring canal outer rim|nurse cell ring canal outer rim|germline ring canal outer rim See also the fly_anatomy.ontology term 'outer nurse cell ring canal rim ; FBbt:00004882'. cellular_component owl:Class
GO:0035324 biolink:NamedThing female germline ring canal An intercellular bridge that connects the germline cells of a female cyst. got7fsn_ti ovarian ring canal|nurse cell ring canal bf 2010-02-25T11:06:41Z cellular_component owl:Class
GO:0140528 biolink:NamedThing bilobe structure assembly The assembly and organization of a bilobe structure, a cytoskeletal structure in some kinetoplastid species linking the structures of the ciliary pocket collar and the flagellum attachment zone (aka cilium attachment zone). got7fsn_ti bilobe structure formation|bilobe structure biogenesis|kinetoplastid flagellar hook complex assembly https://github.com/geneontology/go-ontology/issues/20057 pg 2020-09-30T08:47:39Z biological_process owl:Class
GO:1990964 biolink:NamedThing actin cytoskeleton-regulatory complex A protein complex probably required for the internalization of endosomes during actin-coupled endocytosis. Links the site of endocytosis to the cell membrane-associated actin cytoskeleton, coordinating ARP2/3 stimulation at the later stages of endocytosis. Present in the late endocytic coat. got7fsn_ti An example of this is Pan1 in Saccharomyces cerevisiae (UniProt ID P32521) in PMID:10594004 (inferred from direct assay). bhm 2016-06-09T12:18:30Z cellular_component owl:Class
GO:0048752 biolink:NamedThing semicircular canal morphogenesis The process in which the anatomical structures of the semicircular canals are generated and organized. got7fsn_ti embryonic semicircular canal morphogenesis biological_process owl:Class
GO:0034085 biolink:NamedThing establishment of sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become associated with each other during S phase. got7fsn_ti biological_process owl:Class
GO:2000649 biolink:NamedThing regulation of sodium ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity. got7fsn_ti regulation of sodium transporter activity yaf 2011-04-28T08:42:53Z biological_process owl:Class
GO:0010093 biolink:NamedThing specification of floral organ identity The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:2000791 biolink:NamedThing negative regulation of mesenchymal cell proliferation involved in lung development Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. got7fsn_ti pr 2011-06-24T01:53:53Z biological_process owl:Class
GO:0060786 biolink:NamedThing regulation of cell differentiation involved in tissue homeostasis Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue. got7fsn_ti dph 2009-07-31T01:55:19Z biological_process owl:Class
GO:0003061 biolink:NamedThing positive regulation of the force of heart contraction by norepinephrine The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction. got7fsn_ti increased force of heart contraction by norepinephrine|positive regulation of heart contraction by norepinephrine|positive regulation of heart contraction by adrenaline|noradrenaline cardiac inotropy|noradrenaline regulation of the strength of heart muscle contraction|norepinephrine cardiac inotropy|increased force of heart contraction by adrenaline biological_process owl:Class
GO:0001997 biolink:NamedThing positive regulation of the force of heart contraction by epinephrine-norepinephrine Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings. got7fsn_ti increased force of heart contraction by epinephrine-norepinephrine|increased force of heart contraction by adrenaline-noradrenaline|positive regulation of heart contraction by adrenaline-noradrenaline|increased inotropy by epinephrine-norepinephrine|positive regulation of heart contraction by epinephrine-norepinephrine|increased strength of cardiac contraction by epinephrine-norepinephrine biological_process owl:Class
GO:0061641 biolink:NamedThing CENP-A containing chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin. got7fsn_ti centromeric chromatin organization dph 2014-08-27T12:26:14Z biological_process owl:Class
GO:0020030 biolink:NamedThing infected host cell surface knob Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species. got7fsn_ti cellular_component owl:Class
NCBITaxon:5820 biolink:NamedThing got7fsn_ti owl:Class
GO:0032545 biolink:NamedThing CURI complex A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p. got7fsn_ti cellular_component owl:Class
GO:0001927 biolink:NamedThing exocyst assembly The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex. got7fsn_ti biological_process owl:Class
GO:0071515 biolink:NamedThing genetic imprinting at mating-type locus A genetic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication. got7fsn_ti mating type determination, imprinting mah 2010-01-06T12:58:56Z biological_process owl:Class
GO:0097684 biolink:NamedThing dinoflagellate antapex The anterior most point of a dinoflagellate hypocone. got7fsn_ti antapex The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. pr 2014-12-18T09:32:10Z cellular_component owl:Class
GO:0097614 biolink:NamedThing dinoflagellate hypocone The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum. got7fsn_ti hypocone|hypotheca|hyposome The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. pr 2014-06-09T11:35:07Z cellular_component owl:Class
GO:1904416 biolink:NamedThing negative regulation of xenophagy Any process that stops, prevents or reduces the frequency, rate or extent of xenophagy. got7fsn_ti down-regulation of xenophagy|inhibition of xenophagy|downregulation of xenophagy|down regulation of xenophagy An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). pad 2015-06-29T12:30:53Z biological_process owl:Class
GO:0031953 biolink:NamedThing negative regulation of protein autophosphorylation Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues. got7fsn_ti inhibition of protein amino acid autophosphorylation|down regulation of protein amino acid autophosphorylation|down-regulation of protein amino acid autophosphorylation|downregulation of protein amino acid autophosphorylation|negative regulation of protein amino acid autophosphorylation biological_process owl:Class
GO:0009429 biolink:NamedThing bacterial-type flagellum basal body, proximal rod The portion of the central rod of the bacterial-type flagellar basal body that is proximal to the cell membrane; the proximal rod connects the distal rod to the flagellar motor. got7fsn_ti flagellar basal body, proximal rod|flagellin-based flagellum basal body, proximal rod cellular_component owl:Class
GO:0098802 biolink:NamedThing plasma membrane signaling receptor complex Any protein complex that is part of the plasma membrane and which functions as a signaling receptor. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. cellular_component owl:Class
GO:0046607 biolink:NamedThing positive regulation of centrosome cycle Any process that activates or increases the frequency, rate or extent of the centrosome cycle. got7fsn_ti upregulation of centrosome cycle|stimulation of centrosome cycle|up-regulation of centrosome cycle|activation of centrosome cycle|up regulation of centrosome cycle biological_process owl:Class
GO:0007010 biolink:NamedThing cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. got7fsn_ti cytoskeletal regulator activity|cytoskeletal organization and biogenesis|cytoskeleton organization and biogenesis|cytoskeleton organisation biological_process owl:Class
GO:1903683 biolink:NamedThing positive regulation of epithelial cell-cell adhesion involved in epithelium migration Any process that activates or increases the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. got7fsn_ti up-regulation of epithelial cell-cell adhesion involved in epithelium migration|upregulation of epithelial cell-cell adhesion involved in epithelium migration|up regulation of epithelial cell-cell adhesion involved in epithelium migration|activation of epithelial cell-cell adhesion involved in epithelium migration als 2014-12-01T13:25:22Z biological_process owl:Class
GO:0008086 biolink:NamedThing light-activated voltage-gated calcium channel activity Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti light-activated voltage-dependent calcium channel activity|light-activated voltage gated calcium channel activity molecular_function owl:Class
GO:0099635 biolink:NamedThing voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission. got7fsn_ti molecular_function owl:Class
GO:0060330 biolink:NamedThing regulation of response to interferon-gamma Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. got7fsn_ti regulation of response to immune interferon|regulation of response to type II IFN|regulation of response to gamma-interferon|regulation of response to type II interferon biological_process owl:Class
GO:0004326 biolink:NamedThing tetrahydrofolylpolyglutamate synthase activity Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). got7fsn_ti tetrahydrofolate synthase activity|folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity|FPGS activity|tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)|folate polyglutamate synthetase activity|folylpolyglutamyl synthetase activity|tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity|folylpoly-gamma-glutamate synthase activity|formyltetrahydropteroyldiglutamate synthetase activity|folylpolyglutamate synthase activity|N10-formyltetrahydropteroyldiglutamate synthetase activity|folylpoly(gamma-glutamate) synthase activity|N(10)-formyltetrahydropteroyldiglutamate synthetase activity|folylpolyglutamate synthetase activity|tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming) Reactome:R-HSA-197958|MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN|EC:6.3.2.17|Reactome:R-HSA-200681|RHEA:10580|Reactome:R-HSA-200682 molecular_function owl:Class
GO:0046901 biolink:NamedThing tetrahydrofolylpolyglutamate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolylpolyglutamate, a folate derivative comprising tetrahydrofolate attached to a chain of glutamate residues. got7fsn_ti tetrahydrofolylpolyglutamate synthesis|tetrahydrofolylpolyglutamate formation|tetrahydrofolate polyglutamylation|tetrahydrofolylpolyglutamate biosynthesis|tetrahydrofolyl-[Glu](n) biosynthesis|folic acid-containing compound polyglutamylation|THF polyglutamylation|tetrahydrofolylpolyglutamate anabolism|tetrahydrofolyl-[Glu](n) biosynthetic process biological_process owl:Class
GO:0048767 biolink:NamedThing root hair elongation The process in which the root hair grows longer. got7fsn_ti biological_process owl:Class
GO:0051726 biolink:NamedThing regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle. got7fsn_ti tumor suppressor|positive regulation of cell cycle arrest|arrest of mitotic cell cycle progression|mitotic cell cycle arrest|regulation of progression through cell cycle|cell cycle regulation|modulation of cell cycle progression|cell cycle modulation|regulation of cell cycle progression|negative regulation of cell cycle arrest|cell cycle regulator|regulation of cell cycle arrest|control of cell cycle progression|cell cycle arrest GO:0071850|GO:0071156|GO:0007050|GO:0071158|GO:0071157|GO:0000074 biological_process owl:Class
GO:0043941 biolink:NamedThing positive regulation of sexual sporulation resulting in formation of a cellular spore Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis. got7fsn_ti biological_process owl:Class
GO:0002177 biolink:NamedThing manchette A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments. got7fsn_ti hjd 2010-12-01T02:31:43Z cellular_component owl:Class
GO:1990972 biolink:NamedThing multimerin complex Glycoprotein complex of the C1q/TNF superfamily involved in cell adhesion. A homotrimer that will combine to form supramolecular Multimerin structures. got7fsn_ti Elastic microfibrillar interface 4 complex|p155 complex|EMILIN-3 complex|Multimerin-2 complex|Elastic microfibrillar interface 3 complex|Platelet glycoprotein Ia* complex|Multimerin-1 complex|EMILIN-4 complex An example of this is Multimerin-1 in human (Q13201) in PMID:9454761. bhm 2016-06-21T14:49:42Z cellular_component owl:Class
GO:0033627 biolink:NamedThing cell adhesion mediated by integrin The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits. got7fsn_ti cell adhesion mediated by integrin complex biological_process owl:Class
GO:0005895 biolink:NamedThing interleukin-5 receptor complex A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3. got7fsn_ti IL-5 receptor complex cellular_component owl:Class
GO:0060498 biolink:NamedThing retinoic acid receptor signaling pathway involved in lung bud formation The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands contributing to the formation of the primary lung bud. got7fsn_ti retinoic acid receptor signalling pathway involved in lung bud formation biological_process owl:Class
GO:0001862 biolink:NamedThing collectin binding Binding to a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus. got7fsn_ti Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). molecular_function owl:Class
GO:0035779 biolink:NamedThing angioblast cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells). got7fsn_ti angioblastic mesenchymal cell differentiation bf 2011-04-04T11:10:38Z biological_process owl:Class
GO:0015553 biolink:NamedThing xanthosine transmembrane transporter activity Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015863 biolink:NamedThing xanthosine transport The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0015125 biolink:NamedThing bile acid transmembrane transporter activity Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. got7fsn_ti Reactome:R-HSA-5661198|Reactome:R-HSA-194130|Reactome:R-HSA-194083|Reactome:R-HSA-194079|Reactome:R-HSA-5661184 molecular_function owl:Class
GO:0015721 biolink:NamedThing bile acid and bile salt transport The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti bile salt transport|bile acid transport biological_process owl:Class
GO:0072197 biolink:NamedThing ureter morphogenesis The process in which the anatomical structures of the ureter are generated and organized. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder. got7fsn_ti mah 2010-03-01T02:24:55Z biological_process owl:Class
GO:0061410 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to ethanol Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus. got7fsn_ti dph 2012-01-12T12:17:35Z biological_process owl:Class
GO:0071361 biolink:NamedThing cellular response to ethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. got7fsn_ti mah 2009-12-11T03:02:59Z biological_process owl:Class
GO:0071630 biolink:NamedThing nuclear protein quality control by the ubiquitin-proteasome system The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation. got7fsn_ti nucleus-associated proteasomal ubiquitin-dependent protein degradation|ubiquitin-dependent catabolism of misfolded proteins by nucleus-associated proteasome|nucleus-associated proteasomal ubiquitin-dependent protein breakdown|nucleus-associated proteasomal ubiquitin-dependent protein catabolism See also the biological process terms 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. mah 2010-02-11T03:31:46Z biological_process owl:Class
GO:0035775 biolink:NamedThing pronephric glomerulus morphogenesis The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment. got7fsn_ti This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. bf 2011-04-04T10:59:28Z biological_process owl:Class
GO:0039021 biolink:NamedThing pronephric glomerulus development The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment. got7fsn_ti This term is intended for annotation of fish and other organisms which contain a glomerulus as part of the pronephric nephron. It should not be used for annotation of Xenopus, which contains a pronephric glomus rather than a glomerulus. bf 2010-07-02T10:13:38Z biological_process owl:Class
GO:1903357 biolink:NamedThing regulation of transcription initiation from RNA polymerase I promoter Any process that modulates the frequency, rate or extent of transcription initiation from RNA polymerase I promoter. got7fsn_ti regulation of transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript mah 2014-08-21T10:19:32Z biological_process owl:Class
GO:2000302 biolink:NamedThing positive regulation of synaptic vesicle exocytosis Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis. got7fsn_ti dph 2011-01-03T08:21:14Z biological_process owl:Class
GO:0021638 biolink:NamedThing trigeminal nerve formation The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. got7fsn_ti CN V formation|CN V biosynthesis biological_process owl:Class
GO:1990819 biolink:NamedThing actin fusion focus A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location. got7fsn_ti al 2015-08-10T16:52:15Z cellular_component owl:Class
GO:0004900 biolink:NamedThing erythropoietin receptor activity Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0044697 biolink:NamedThing HICS complex A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins. got7fsn_ti jl 2012-09-19T13:30:22Z cellular_component owl:Class
GO:0035880 biolink:NamedThing embryonic nail plate morphogenesis The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits. got7fsn_ti bf 2011-05-31T02:38:57Z biological_process owl:Class
GO:0034388 biolink:NamedThing Pwp2p-containing subcomplex of 90S preribosome A protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p. got7fsn_ti UTP-B complex|25-30 S subcomplex of 90S preribosome Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. cellular_component owl:Class
GO:0010433 biolink:NamedThing bract morphogenesis The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. got7fsn_ti biological_process owl:Class
GO:0060043 biolink:NamedThing regulation of cardiac muscle cell proliferation Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation. got7fsn_ti regulation of cardiomyocyte proliferation|regulation of heart muscle cell proliferation biological_process owl:Class
GO:0055017 biolink:NamedThing cardiac muscle tissue growth The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another. got7fsn_ti heart muscle growth biological_process owl:Class
GO:0007496 biolink:NamedThing anterior midgut development The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0007494 biolink:NamedThing midgut development The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine. got7fsn_ti biological_process owl:Class
GO:0032069 biolink:NamedThing regulation of nuclease activity Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids. got7fsn_ti nuclease regulator activity biological_process owl:Class
GO:0033175 biolink:NamedThing chloroplast proton-transporting ATP synthase complex, coupling factor CF(o) All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins. got7fsn_ti chloroplast proton-transporting ATP synthase complex, coupling factor CF(0)|chloroplast proton-transporting F-type ATPase complex, coupling factor CF(o) cellular_component owl:Class
GO:0042776 biolink:NamedThing mitochondrial ATP synthesis coupled proton transport The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. got7fsn_ti mitochondrial proton transport biological_process owl:Class
GO:0071097 biolink:NamedThing alphaV-beta3 integrin-paxillin-Pyk2 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to paxillin and the FAK-related kinase Pyk2. got7fsn_ti ITGAV-ITGB3-PXN-PTK2b complex mah 2009-11-06T04:51:52Z cellular_component owl:Class
GO:0072380 biolink:NamedThing TRC complex A protein complex found in yeast that contains GET4, MDY2 (GET5), SGT2, and at least two heat shock proteins, HSP104 and YBR137W. The TRC complex transfers tail-anchored (TA) proteins to GET3 for targeting to the endoplasmic reticulum membrane. got7fsn_ti TMD recognition complex|GET4-GET5 transmembrane domain recognition complex https://github.com/geneontology/go-ontology/issues/20889 mah 2010-11-24T02:43:41Z cellular_component owl:Class
GO:0015346 biolink:NamedThing ferric triacetylfusarinine C:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in). got7fsn_ti ferric triacetylfusarinine C:hydrogen symporter activity molecular_function owl:Class
GO:0015686 biolink:NamedThing ferric triacetylfusarinine C import into cell The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti ferric triacetylfusarinine C transport biological_process owl:Class
GO:0060163 biolink:NamedThing subpallium neuron fate commitment The process in which in the subpallium, the developmental fate of a cell becomes restricted such that it will develop into a neuron. The subpallium is the base region of the telencephalon. got7fsn_ti subpallium neuronal precursor fate commitment biological_process owl:Class
GO:1990184 biolink:NamedThing amino acid transport complex A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane. got7fsn_ti jl 2013-09-11T15:02:16Z cellular_component owl:Class
GO:0110027 biolink:NamedThing negative regulation of DNA strand resection involved in replication fork processing Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing. got7fsn_ti kmv 2017-07-05T18:39:49Z biological_process owl:Class
GO:0034091 biolink:NamedThing regulation of maintenance of sister chromatid cohesion Any process that modulates the extent to which the association between sister chromatids of a replicated chromosome is maintained. got7fsn_ti biological_process owl:Class
GO:0044799 biolink:NamedThing NarGHI complex A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit. got7fsn_ti nitrate reductase A|cytoplasmic membrane-bound quinol-nitrate oxidoreductase jl 2013-08-29T14:17:41Z cellular_component owl:Class
GO:0048866 biolink:NamedThing stem cell fate specification The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0001175 biolink:NamedThing transcriptional start site selection at RNA polymerase III promoter Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. got7fsn_ti krc 2011-06-20T01:47:38Z biological_process owl:Class
GO:1905616 biolink:NamedThing regulation of miRNA mediated inhibition of translation Any process that modulates the frequency, rate or extent of miRNA mediated inhibition of translation. got7fsn_ti regulation of gene silencing by miRNA, negative regulation of translation|regulation of downregulation of translation involved in gene silencing by miRNA|regulation of negative regulation of translation involved in gene silencing by microRNA|regulation of inhibition of translation involved in gene silencing by miRNA|regulation of down regulation of translation involved in gene silencing by miRNA|regulation of miRNA-mediated gene silencing, negative regulation of translation|regulation of down-regulation of translation involved in gene silencing by miRNA bc 2016-10-28T11:47:49Z biological_process owl:Class
GO:0050884 biolink:NamedThing neuromuscular process controlling posture Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts. got7fsn_ti regulation of posture biological_process owl:Class
GO:0060978 biolink:NamedThing angiogenesis involved in coronary vascular morphogenesis Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. got7fsn_ti coronary blood vessel angiogenesis|angiogenesis involved in heart vascular morphogenesis|angiogenesis involved in cardiac vascular morphogenesis|coronary vasculature angiogenesis dph 2009-10-06T02:02:12Z biological_process owl:Class
GO:0062092 biolink:NamedThing Yae1-Lto1 complex A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p. got7fsn_ti dph 2018-11-15T17:39:46Z cellular_component owl:Class
GO:0008103 biolink:NamedThing oocyte microtubule cytoskeleton polarization Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster. got7fsn_ti GO:0048129 biological_process owl:Class
GO:0120021 biolink:NamedThing oxysterol transfer activity Removes oxysterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti intermembrane oxysterol transfer activity|oxysterol carrier activity https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-17T04:50:30Z molecular_function owl:Class
GO:0008142 biolink:NamedThing oxysterol binding Binding to oxysterol, an oxidized form of cholesterol. got7fsn_ti molecular_function owl:Class
GO:2000263 biolink:NamedThing regulation of blood coagulation, extrinsic pathway Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway. got7fsn_ti mah 2010-11-23T11:44:35Z biological_process owl:Class
GO:0035846 biolink:NamedThing oviduct epithelium development The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct. got7fsn_ti fallopian tube epithelium development bf 2011-05-10T10:53:05Z biological_process owl:Class
GO:0051178 biolink:NamedThing meiotic chromosome decondensation The cell cycle process in which chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells. got7fsn_ti biological_process owl:Class
GO:0052541 biolink:NamedThing plant-type cell wall cellulose metabolic process The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as part of the organization and biogenesis of the cell wall. got7fsn_ti cellulose and pectin-containing cell wall cellulose metabolic process|cell wall cellulose metabolism biological_process owl:Class
GO:0005391 biolink:NamedThing P-type sodium:potassium-exchanging transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). got7fsn_ti P-type sodium:potassium-exchanging ATPase activity|Na+/K+-ATPase activity|sodium pump|Na+,K+-ATPase activity|Na(+)/K(+)-exchanging ATPase activity|sodium/potassium-transporting ATPase activity|Na+/K+-exchanging ATPase activity|sodium:potassium exchanging ATPase activity|Na,K-activated ATPase activity|sodium/potassium-exchanging ATPase activity|Na(+)/K(+)-ATPase activity|sodium:potassium-exchanging ATPase activity https://github.com/geneontology/go-ontology/issues/17289 Reactome:R-HSA-936897|Wikipedia:ATPase,_Na%2B/K%2B_transporting,_alpha_1|MetaCyc:3.6.3.9-RXN|EC:7.2.2.13|RHEA:18353|TC:3.A.3.1.1 molecular_function owl:Class
GO:0010248 biolink:NamedThing establishment or maintenance of transmembrane electrochemical gradient The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0043310 biolink:NamedThing negative regulation of eosinophil degranulation Any process that stops, prevents, or reduces the rate of eosinophil degranulation. got7fsn_ti down regulation of eosinophil degranulation|inhibition of eosinophil degranulation|negative regulation of eosinophil granule exocytosis|down-regulation of eosinophil degranulation|downregulation of eosinophil degranulation biological_process owl:Class
GO:0016592 biolink:NamedThing mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. got7fsn_ti L mediator complex|CDK8-containing TRAP/mediator complex|Srb-mediator complex|TRAP complex GO:0000119 Wikipedia:Mediator_(coactivator) cellular_component owl:Class
GO:0070847 biolink:NamedThing core mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. got7fsn_ti C mediator complex|S mediator complex https://github.com/geneontology/go-ontology/issues/15979 mah 2009-08-04T02:56:11Z cellular_component owl:Class
GO:0097537 biolink:NamedThing Y-shaped link A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium. got7fsn_ti Y-link structure|membrane-microtubule complex|Y-shaped linker|Y-shaped fibre|Y-shaped assemblage|Y-shaped fiber|Y-link pr 2013-12-03T16:34:34Z cellular_component owl:Class
GO:0050971 biolink:NamedThing detection of mechanical stimulus involved in magnetoreception The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field. got7fsn_ti magnetoreception, sensory detection of mechanical stimulus|sensory transduction of mechanical stimulus during magnetoreception|magnetoception, sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus during magnetoreception|magnetoreception, sensory transduction of mechanical stimulus|magnetoreception, detection of mechanical stimulus biological_process owl:Class
GO:0050979 biolink:NamedThing magnetoreception by sensory perception of mechanical stimulus The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field. got7fsn_ti magnetoreception, using mechanical stimulus|magnetoreception through mechanical stimulus|magnetoreception, sensory perception of mechanical stimulus biological_process owl:Class
GO:0042686 biolink:NamedThing regulation of cardioblast cell fate specification Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti biological_process owl:Class
GO:0048756 biolink:NamedThing sieve cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials. got7fsn_ti biological_process owl:Class
GO:0005966 biolink:NamedThing cyclic-nucleotide phosphodiesterase complex An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide. got7fsn_ti photoreceptor cyclic-nucleotide phosphodiesterase complex cellular_component owl:Class
GO:0031664 biolink:NamedThing regulation of lipopolysaccharide-mediated signaling pathway Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. got7fsn_ti regulation of lipopolysaccharide-mediated signalling pathway|regulation of LPS-mediated signaling pathway biological_process owl:Class
GO:0015626 biolink:NamedThing L-diaminopimelate transmembrane transporter activity Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid. got7fsn_ti L-diaminopimelate transporter activity|cystine/diaminopimelate porter activity molecular_function owl:Class
GO:0015830 biolink:NamedThing diaminopimelate transport The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0046689 biolink:NamedThing response to mercury ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. got7fsn_ti mercuric sensitivity/resistance|response to mercuric ion|response to mercury biological_process owl:Class
GO:0048597 biolink:NamedThing post-embryonic camera-type eye morphogenesis The process in which the anatomical structures of the eye are generated and organized during post-embryonic development. got7fsn_ti post-embryonic eye morphogenesis|post-embryonic camera-style eye morphogenesis biological_process owl:Class
GO:0038167 biolink:NamedThing epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via activation of the transcription factor NF-kappaB. got7fsn_ti epidermal growth factor receptor signalling pathway via positive regulation of NF-kappaB transcription factor activity|EGFR signaling pathway via activation of NF-kappaB bf 2012-05-15T11:49:30Z biological_process owl:Class
GO:0015217 biolink:NamedThing ADP transmembrane transporter activity Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015866 biolink:NamedThing ADP transport The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0003204 biolink:NamedThing cardiac skeleton development The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart. got7fsn_ti heart fibrous skeleton development dph 2009-10-13T09:05:04Z biological_process owl:Class
GO:0045664 biolink:NamedThing regulation of neuron differentiation Any process that modulates the frequency, rate or extent of neuron differentiation. got7fsn_ti biological_process owl:Class
GO:1905304 biolink:NamedThing regulation of cardiac myofibril assembly Any process that modulates the frequency, rate or extent of cardiac myofibril assembly. got7fsn_ti regulation of cardiac myofibril morphogenesis|regulation of cardiac myofibril development|regulation of heart myofibril assembly rl 2016-07-06T10:01:49Z biological_process owl:Class
GO:1990156 biolink:NamedThing DnaB-DnaG complex A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes. got7fsn_ti DnaB-DnaG primosome complex bhm 2013-08-02T09:50:54Z cellular_component owl:Class
GO:0015658 biolink:NamedThing branched-chain amino acid transmembrane transporter activity Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. got7fsn_ti branched-chain aliphatic amino acid transporter activity|valine/tyrosine/tryptophan permease activity|leucine/valine/isoleucine permease activity|branched-chain aliphatic amino acid transmembrane transporter activity GO:1901240 Reactome:R-HSA-9672770 molecular_function owl:Class
GO:0015803 biolink:NamedThing branched-chain amino acid transport The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. got7fsn_ti branched-chain amino-acid anions transport|branched-chain aliphatic amino acid transport|branched-chain amino-acid anion transport GO:1900755 biological_process owl:Class
GO:0015902 biolink:NamedThing carbonyl cyanide m-chlorophenylhydrazone transport The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes. got7fsn_ti CCCP transport biological_process owl:Class
GO:2000746 biolink:NamedThing regulation of defecation rhythm Any process that modulates the frequency, rate or extent of defecation rhythm. got7fsn_ti regulation of defecation motor program|regulation of defecation cycle|regulation of DMP|regulation of defecation behavior bf 2011-06-15T03:23:07Z biological_process owl:Class
GO:0140132 biolink:NamedThing iron-sulfur cluster carrier activity Binding to an iron-sulfur cluster and delivering it to an acceptor molecule. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14539 pg 2017-11-10T08:55:38Z molecular_function owl:Class
GO:0015615 biolink:NamedThing D-allose-importing ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in). got7fsn_ti D-allose porter activity molecular_function owl:Class
GO:0015754 biolink:NamedThing allose transmembrane transport The process in which allose is transported across a lipid bilayer, from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. got7fsn_ti allose transport biological_process owl:Class
GO:0060596 biolink:NamedThing mammary placode formation The developmental process in which the mammary placode forms. The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper. got7fsn_ti dph 2009-05-13T11:55:20Z biological_process owl:Class
GO:0098682 biolink:NamedThing arciform density An electron dense structure that anchors a synaptic ribbon to the presynaptic membrane. got7fsn_ti dos 2017-02-05T16:12:22Z cellular_component owl:Class
GO:0014022 biolink:NamedThing neural plate elongation The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions. got7fsn_ti biological_process owl:Class
GO:0001839 biolink:NamedThing neural plate morphogenesis The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue. got7fsn_ti biological_process owl:Class
GO:0010059 biolink:NamedThing positive regulation of atrichoblast fate specification Any process that induces or promotes atrichoblast fate specification. got7fsn_ti upregulation of atrichoblast fate|stimulation of atrichoblast fate|up regulation of atrichoblast fate|up-regulation of atrichoblast fate|activation of atrichoblast fate biological_process owl:Class
GO:2000144 biolink:NamedThing positive regulation of DNA-templated transcription, initiation Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation. got7fsn_ti positive regulation of DNA-dependent transcription, initiation|positive regulation of initiation of DNA-dependent transcription|positive regulation of transcription initiation, DNA-dependent|transactivation|transcriptional transactivation mah 2010-10-01T09:11:43Z biological_process owl:Class
GO:0044361 biolink:NamedThing negative regulation of voltage-gated potassium channel activity in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism. got7fsn_ti jl 2011-10-27T02:11:52Z biological_process owl:Class
GO:0071998 biolink:NamedThing ascospore release from ascus A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive. got7fsn_ti ascospore liberation mah 2010-10-25T03:41:44Z biological_process owl:Class
GO:0098046 biolink:NamedThing type V protein secretion system complex A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). got7fsn_ti T5SS complex|autotransporter system complex Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. bf 2012-08-01T10:05:49Z cellular_component owl:Class
GO:1990902 biolink:NamedThing new cell pole The cell pole proximal to the most recent cell division. got7fsn_ti pr 2015-11-17T16:44:53Z cellular_component owl:Class
GO:1990890 biolink:NamedThing netrin receptor binding Binding to a netrin receptor. got7fsn_ti kmv 2015-11-02T22:56:07Z molecular_function owl:Class
GO:0099145 biolink:NamedThing regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane. got7fsn_ti dos 2017-06-09T18:49:26Z biological_process owl:Class
GO:0048635 biolink:NamedThing negative regulation of muscle organ development Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development. got7fsn_ti downregulation of muscle development|down regulation of muscle development|inhibition of muscle development|down-regulation of muscle development biological_process owl:Class
GO:0021695 biolink:NamedThing cerebellar cortex development The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function. got7fsn_ti biological_process owl:Class
GO:0009276 biolink:NamedThing Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. got7fsn_ti 1-2nm peptidoglycan-based cell wall|cell wall inner membrane cellular_component owl:Class
GO:0030313 biolink:NamedThing cell envelope An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present. got7fsn_ti Wikipedia:Cell_envelope cellular_component owl:Class
GO:0061387 biolink:NamedThing regulation of extent of cell growth Any process that modulates the extent of cell growth. got7fsn_ti dph 2011-07-14T10:15:42Z biological_process owl:Class
GO:0009838 biolink:NamedThing abscission The controlled shedding of a body part. got7fsn_ti Wikipedia:Abscission biological_process owl:Class
CL:0000617 biolink:NamedThing got7fsn_ti owl:Class
GO:0016490 biolink:NamedThing structural constituent of peritrophic membrane The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster. got7fsn_ti structural constituent of peritrophic matrix molecular_function owl:Class
GO:0140495 biolink:NamedThing migracytosis A cell migration-dependent mechanism for releasing cellular contents. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19760 pg 2020-07-10T15:13:46Z biological_process owl:Class
GO:0009512 biolink:NamedThing cytochrome b6f complex Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. got7fsn_ti cyt b6-f complex|cyt b(6)f complex|cyt b6f complex|cytochrome b(6)f complex|cytochrome b6-f complex|cyt b6/f complex|cytochrome b6/f complex Wikipedia:Cytochrome_b6f_complex cellular_component owl:Class
GO:0032766 biolink:NamedThing NHE3/E3KARP/ACTN4 complex A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments. got7fsn_ti NHE3/E3KARP/alpha-actinin complex cellular_component owl:Class
GO:0120034 biolink:NamedThing positive regulation of plasma membrane bounded cell projection assembly Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly. got7fsn_ti https://github.com/geneontology/go-ontology/issues/13298 krc 2017-04-26T04:34:45Z biological_process owl:Class
GO:0140233 biolink:NamedThing intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential. got7fsn_ti intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential https://github.com/geneontology/synapse/issues/231 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-09T11:31:18Z molecular_function owl:Class
GO:0007053 biolink:NamedThing spindle assembly involved in male meiosis The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0090481 biolink:NamedThing pyrimidine nucleotide-sugar transmembrane transport The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. got7fsn_ti pyrimidine nucleotide-sugar membrane transport|pyrimidine nucleotide-sugar transport Note that this term is not intended for use in annotating lateral movement within membranes. tb 2012-10-01T16:43:54Z GO:0015781 biological_process owl:Class
GO:0002074 biolink:NamedThing extraocular skeletal muscle development The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus. got7fsn_ti biological_process owl:Class
GO:0009873 biolink:NamedThing ethylene-activated signaling pathway A series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription. got7fsn_ti ethylene mediated signaling pathway|ethylene signal transduction|ethene mediated signalling pathway|ethene mediated signaling pathway|ethylene signaling pathway|ethylene mediated signalling pathway biological_process owl:Class
GO:0071369 biolink:NamedThing cellular response to ethylene stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus. got7fsn_ti cellular response to ethene stimulus mah 2009-12-11T03:13:57Z biological_process owl:Class
GO:0001756 biolink:NamedThing somitogenesis The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo. got7fsn_ti formation of mesodermal clusters Wikipedia:Somitogenesis biological_process owl:Class
GO:0000462 biolink:NamedThing maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. got7fsn_ti maturation of 18S rRNA GO:1990041 biological_process owl:Class
GO:2000238 biolink:NamedThing regulation of tRNA export from nucleus Any process that modulates the frequency, rate or extent of tRNA export from nucleus. got7fsn_ti regulation of tRNA-nucleus export|regulation of tRNA transport from nucleus to cytoplasm|regulation of tRNA export from cell nucleus|regulation of tRNA export out of nucleus mah 2010-11-10T12:39:33Z biological_process owl:Class
GO:1903481 biolink:NamedThing negative regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly Any process that stops, prevents or reduces the frequency, rate or extent of actin filament organization involved in mitotic actomyosin contractile ring assembly. got7fsn_ti inhibition of actin filament organisation involved in mitotic actomyosin contractile ring assembly|inhibition of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|downregulation of actin filament organization involved in mitotic actomyosin contractile ring assembly|down-regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|down regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|negative regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|downregulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|downregulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|down-regulation of actin filament organisation involved in mitotic actomyosin contractile ring assembly|down regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly|negative regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|down-regulation of actin filament organization involved in mitotic actomyosin contractile ring assembly|down regulation of actin filament organisation involved in contractile ring assembly involved in mitotic cytokinesis|inhibition of actin filament organization involved in mitotic actomyosin contractile ring assembly vw 2014-09-23T16:03:50Z biological_process owl:Class
GO:0046815 biolink:NamedThing genome retention in viral capsid Any process in which the viral genome is retained within the capsid during genome cleavage and packaging. got7fsn_ti biological_process owl:Class
GO:0019079 biolink:NamedThing viral genome replication Any process involved directly in viral genome replication, including viral nucleotide metabolism. got7fsn_ti viral replication|sigma virus replication biological_process owl:Class
GO:0003995 biolink:NamedThing acyl-CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. got7fsn_ti long-chain acyl coenzyme A dehydrogenase activity|acyl-CoA reductase activity|acyl CoA dehydrogenase activity|acyl coenzyme A dehydrogenase activity|general acyl CoA dehydrogenase activity|medium-chain acyl-coenzyme A dehydrogenase activity|fatty-acyl-CoA dehydrogenase activity|fatty acyl coenzyme A dehydrogenase activity|medium-chain acyl-CoA dehydrogenase activity|long-chain acyl-CoA dehydrogenase activity|acyl-CoA:acceptor 2,3-oxidoreductase activity|acyl-CoA:(acceptor) 2,3-oxidoreductase activity|acyl dehydrogenase activity GO:0019109 Reactome:R-HSA-77263|Reactome:R-HSA-70859|Reactome:R-HSA-5695989|Reactome:R-HSA-77319|Reactome:R-HSA-109341|Reactome:R-HSA-77327|EC:1.3.99.3|Reactome:R-HSA-70800|Reactome:R-HSA-77299|Reactome:R-HSA-77338|Reactome:R-HSA-77345|MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN|Reactome:R-HSA-77274|MetaCyc:ACYLCOADEHYDROG-RXN|Reactome:R-HSA-5695980 molecular_function owl:Class
GO:0007547 biolink:NamedThing germ-line processes downstream of sex determination signal The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways. got7fsn_ti biological_process owl:Class
GO:0018992 biolink:NamedThing germ-line sex determination The determination of sex and sexual phenotype in an organism's germ line. got7fsn_ti biological_process owl:Class
GO:0098045 biolink:NamedThing virus baseplate assembly The aggregation, arrangement and bonding together of a set of components to form a virus baseplate. got7fsn_ti bm 2012-07-25T14:50:32Z biological_process owl:Class
GO:0098003 biolink:NamedThing viral tail assembly The aggregation, arrangement and bonding together of a set of components to form a virus tail. got7fsn_ti bacteriophage tail assembly|virus tail assembly bm 2012-07-18T16:01:59Z biological_process owl:Class
GO:0033551 biolink:NamedThing monopolin complex A protein complex required for clamping microtubule binding sites, ensuring orientation of sister kinetochores to the same pole (mono-orientation) during meiosis I. In the yeast S. cerevisiae this complex consists of Csm1p, Lrs4p, Hrr25p and Mam1p; in S. pombe Psc1 and Mde4 have been identified as subunits. got7fsn_ti Pcs1/Mde4 complex|monopolin subcomplex Csm1/Lrs4 cellular_component owl:Class
GO:0010480 biolink:NamedThing microsporocyte differentiation The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell. got7fsn_ti pollen mother cell differentiation biological_process owl:Class
GO:0043540 biolink:NamedThing 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis. got7fsn_ti 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 complex|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 complex|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 complex Note that we use this single class to represent all 4 isoforms of this complex. We decided to do this because the isoforms do not differ in function, rather in expression and regulation. We may want to revisit this in future. cellular_component owl:Class
GO:0061621 biolink:NamedThing canonical glycolysis The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP. got7fsn_ti dph 2014-04-14T09:21:54Z MetaCyc:PWY66-400|Wikipedia:Glycolysis|Reactome:R-HSA-70171|MetaCyc:ANAGLYCOLYSIS-PWY biological_process owl:Class
GO:0036186 biolink:NamedThing early phagosome membrane The lipid bilayer surrounding an early phagosome. got7fsn_ti early phagocytic vesicle membrane bf 2012-04-16T02:37:30Z cellular_component owl:Class
GO:0032009 biolink:NamedThing early phagosome A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis. got7fsn_ti early phagocytic vesicle cellular_component owl:Class
GO:1990590 biolink:NamedThing ATF1-ATF4 transcription factor complex Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway. got7fsn_ti An example of this is ATF1in human (P18846) in PMID:12871976 (inferred from physical interaction). bhm 2014-12-15T14:25:56Z cellular_component owl:Class
GO:0017055 biolink:NamedThing negative regulation of RNA polymerase II transcription preinitiation complex assembly Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. got7fsn_ti negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis|inhibition of RNA polymerase II transcriptional preinitiation complex assembly|downregulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|down-regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly|negative regulation of RNA polymerase II transcriptional preinitiation complex formation|down regulation of RNA polymerase II transcriptional preinitiation complex assembly biological_process owl:Class
GO:0048441 biolink:NamedThing petal development The process whose specific outcome is the progression of the petal over time, from its formation to the mature structure. got7fsn_ti GO:0048417 biological_process owl:Class
GO:0062049 biolink:NamedThing protein phosphatase inhibitor complex A protein-containing complex that inhibits protein phosphatase activity by directly binding to a protein phosphatase. got7fsn_ti dph 2018-05-30T19:03:26Z cellular_component owl:Class
GO:0035308 biolink:NamedThing negative regulation of protein dephosphorylation Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein. got7fsn_ti down regulation of protein amino acid dephosphorylation|downregulation of protein amino acid dephosphorylation|inhibition of protein amino acid dephosphorylation|down-regulation of protein amino acid dephosphorylation|negative regulation of protein amino acid dephosphorylation biological_process owl:Class
GO:0090261 biolink:NamedThing positive regulation of inclusion body assembly Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. got7fsn_ti tb 2010-02-03T04:23:54Z biological_process owl:Class
GO:0072087 biolink:NamedThing renal vesicle development The process whose specific outcome is the progression of the renal vesicle over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells. got7fsn_ti mah 2010-02-08T01:18:31Z biological_process owl:Class
GO:0033365 biolink:NamedThing protein localization to organelle A process in which a protein is transported to, or maintained in, a location within an organelle. got7fsn_ti protein localization in organelle|protein localisation to organelle biological_process owl:Class
GO:0021628 biolink:NamedThing olfactory nerve formation The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem. got7fsn_ti CN I formation|CN I biosynthesis biological_process owl:Class
GO:0010346 biolink:NamedThing shoot axis formation The process that gives rise to a shoot axis. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti shoot formation biological_process owl:Class
GO:0048886 biolink:NamedThing neuromast hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. got7fsn_ti biological_process owl:Class
GO:0009620 biolink:NamedThing response to fungus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus. got7fsn_ti response to fungi GO:0009621 biological_process owl:Class
GO:0015695 biolink:NamedThing organic cation transport The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. got7fsn_ti biological_process owl:Class
GO:0008282 biolink:NamedThing inward rectifying potassium channel A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity. got7fsn_ti ATP-sensitive potassium channel complex|Kir6.1-SURx complex|Kir6.x complex|KCNJ11-SUR complex|Kir6.1-SUR complex|Kir6.2-SURx complex|KCNJ8-SURx complex|Kir6.x-SURx complex|KCNJ8-SUR complex|inward rectifying K+ channel|KCNJ11-SURx complex|Kir6-SUR complex|Kir6.2-SUR complex cellular_component owl:Class
GO:0016515 biolink:NamedThing interleukin-13 receptor activity Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-13 receptor activity|IL-13R molecular_function owl:Class
GO:0035772 biolink:NamedThing interleukin-13-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-13-mediated signaling pathway|interleukin-13-mediated signalling pathway bf 2011-04-01T11:00:11Z biological_process owl:Class
GO:0034469 biolink:NamedThing Golgi stack lumen The volume enclosed by any of the membranes of the thin, flattened cisternae that form the central portion of the Golgi complex. got7fsn_ti cellular_component owl:Class
GO:2000142 biolink:NamedThing regulation of DNA-templated transcription, initiation Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation. got7fsn_ti regulation of transcription initiation, DNA-dependent|regulation of initiation of DNA-dependent transcription|regulation of DNA-dependent transcription, initiation mah 2010-10-01T09:11:35Z biological_process owl:Class
GO:0014058 biolink:NamedThing negative regulation of acetylcholine secretion, neurotransmission Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine. got7fsn_ti downregulation of acetylcholine secretion|down regulation of acetylcholine secretion|inhibition of acetylcholine secretion|down-regulation of acetylcholine secretion biological_process owl:Class
GO:0046811 biolink:NamedThing histone deacetylase inhibitor activity Binds to and stops, prevents or reduces the activity of histone deacetylase, which catalyzes of the removal of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. got7fsn_ti molecular_function owl:Class
GO:0031064 biolink:NamedThing negative regulation of histone deacetylation Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones. got7fsn_ti inhibition of histone deacetylation|down-regulation of histone deacetylation|down regulation of histone deacetylation|downregulation of histone deacetylation biological_process owl:Class
GO:0008340 biolink:NamedThing determination of adult lifespan The control of viability and duration in the adult phase of the life-cycle. got7fsn_ti biological_process owl:Class
GO:0010259 biolink:NamedThing multicellular organism aging An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700). got7fsn_ti biological_process owl:Class
GO:1990934 biolink:NamedThing nucleolus-like body A nuclear compartment containing significant amounts of non-nucleolar, spliceosomal components. It is commonly found in germinal vesicle (GV) stage oocytes, and is similar to both nucleoli and sphere organelles. got7fsn_ti compact nucleolus|NLB|nucleolus-like body sl 2016-03-21T21:28:14Z cellular_component owl:Class
GO:0019080 biolink:NamedThing viral gene expression A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation. got7fsn_ti viral genome expression biological_process owl:Class
GO:0031674 biolink:NamedThing I band A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end. got7fsn_ti I disc|isotropic disc|J disc Wikipedia:Sarcomere#bands cellular_component owl:Class
GO:0045972 biolink:NamedThing negative regulation of juvenile hormone secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of juvenile hormone. got7fsn_ti downregulation of juvenile hormone secretion|down-regulation of juvenile hormone secretion|inhibition of juvenile hormone secretion|down regulation of juvenile hormone secretion biological_process owl:Class
GO:0000290 biolink:NamedThing deadenylation-dependent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length. got7fsn_ti deadenylation-dependent decapping of nuclear mRNA|deadenylylation-dependent decapping biological_process owl:Class
GO:0003237 biolink:NamedThing sinus venosus formation The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart. got7fsn_ti dph 2009-10-13T11:18:34Z biological_process owl:Class
GO:0005945 biolink:NamedThing 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. got7fsn_ti cellular_component owl:Class
GO:0038092 biolink:NamedThing nodal signaling pathway A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti nodal signaling|nodal signalling pathway bf 2012-02-16T02:44:02Z biological_process owl:Class
GO:0060655 biolink:NamedThing branching involved in mammary gland cord morphogenesis The process in which the branching structure of the mammary gland cord is generated and organized. The mammary gland cord is a solid epithelial structure that will hollow out, forming the mammary duct. got7fsn_ti dph 2009-05-29T09:29:32Z biological_process owl:Class
GO:0048407 biolink:NamedThing platelet-derived growth factor binding Binding to platelet-derived growth factor. got7fsn_ti PDGF binding molecular_function owl:Class
GO:0061780 biolink:NamedThing mitotic cohesin loading The protein localization to chromatin by which a cohesin ring complex is topologically linked to DNA as part of the mitotic cell cycle. got7fsn_ti dph 2016-08-23T13:00:34Z biological_process owl:Class
GO:0034087 biolink:NamedThing establishment of mitotic sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a mitotic cell cycle. got7fsn_ti biological_process owl:Class
GO:0030386 biolink:NamedThing ferredoxin-thioredoxin reductase complex A protein complex that possesses ferredoxin-thioredoxin reductase activity. got7fsn_ti ferredoxin:thioredoxin reductase complex Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin-thioredoxin reductase activity ; GO:0103012'. cellular_component owl:Class
NCBITaxon:Union_0000002 biolink:NamedThing got7fsn_ti owl:Class
GO:1990569 biolink:NamedThing UDP-N-acetylglucosamine transmembrane transport The process in which UDP-N-acetylglucosamine is transported across a membrane. got7fsn_ti UDP-N-acetylglucosamine transport vw 2014-11-27T11:56:35Z GO:0015788 biological_process owl:Class
GO:0032293 biolink:NamedThing non-myelinated axon ensheathment in central nervous system The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system. got7fsn_ti ensheathment of non-myelinated axons in central nervous system biological_process owl:Class
GO:0007508 biolink:NamedThing larval heart development The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper. got7fsn_ti biological_process owl:Class
GO:0033111 biolink:NamedThing attachment organelle membrane The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane. got7fsn_ti cellular_component owl:Class
GO:0033099 biolink:NamedThing attachment organelle A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division. got7fsn_ti cellular_component owl:Class
GO:0034463 biolink:NamedThing 90S preribosome assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a 90S preribosome. The 90S preribosome represents the complex that forms on the primary rRNA transcript before it splits into the small subunit and large subunit portions. got7fsn_ti biological_process owl:Class
GO:0010632 biolink:NamedThing regulation of epithelial cell migration Any process that modulates the frequency, rate or extent of epithelial cell migration. got7fsn_ti biological_process owl:Class
GO:0019974 biolink:NamedThing interleukin-14 binding Binding to interleukin-14. got7fsn_ti IL-14 binding molecular_function owl:Class
GO:0021648 biolink:NamedThing vestibulocochlear nerve morphogenesis The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. got7fsn_ti CN VIII morphogenesis biological_process owl:Class
GO:0021562 biolink:NamedThing vestibulocochlear nerve development The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. got7fsn_ti CN VIII development|cranial nerve 8 development|cranial nerve VIII development|acoustic nerve development biological_process owl:Class
GO:1990826 biolink:NamedThing nucleoplasmic periphery of the nuclear pore complex Nucleoplasm situated in close proximity and peripheral to a nuclear pore complex. got7fsn_ti associated with the nuclear pore https://github.com/geneontology/go-ontology/issues/21774 sl 2015-08-19T18:26:26Z cellular_component owl:Class
GO:0110114 biolink:NamedThing negative regulation of lipid transporter activity Any process that decreases the frequency, rate, or extent of lipid transporter activity. got7fsn_ti kmv 2018-07-06T19:21:44Z biological_process owl:Class
GO:0060324 biolink:NamedThing face development The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head. got7fsn_ti biological_process owl:Class
GO:0010073 biolink:NamedThing meristem maintenance Any process involved in maintaining the identity, size and shape of a meristem. got7fsn_ti biological_process owl:Class
GO:0015146 biolink:NamedThing pentose transmembrane transporter activity Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms. got7fsn_ti molecular_function owl:Class
GO:0015750 biolink:NamedThing pentose transmembrane transport The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule. got7fsn_ti pentose transport biological_process owl:Class
GO:0000755 biolink:NamedThing cytogamy During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti zygote formation GO:0030462|GO:0000218 biological_process owl:Class
GO:0021980 biolink:NamedThing subpallium cell migration The orderly movement of cells from one site to another in the subpallium. got7fsn_ti biological_process owl:Class
GO:1903667 biolink:NamedThing regulation of chemorepellent activity Any process that modulates the frequency, rate or extent of chemorepellent activity. got7fsn_ti regulation of chemorepellant activity pf 2014-11-26T23:58:33Z biological_process owl:Class
GO:0060133 biolink:NamedThing somatotropin secreting cell development The process whose specific outcome is the progression of a somatotropin secreting cell over time, from its formation to the mature structure. A somatotropin secreting cell is an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin. got7fsn_ti somatotrophin secreting cell development|somatotrope development|growth hormone secreting cell development|somatrophic cell development|somatotropic cell development|somatotroph development biological_process owl:Class
GO:0032937 biolink:NamedThing SREBP-SCAP-Insig complex A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane. got7fsn_ti cellular_component owl:Class
GO:0098841 biolink:NamedThing protein localization to cell division site after cytokinesis A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis. got7fsn_ti biological_process owl:Class
GO:0060132 biolink:NamedThing prolactin secreting cell development The process whose specific outcome is the progression of a prolactin secreting cell over time, from its formation to the mature structure. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin. got7fsn_ti lactotroph development|mammotrope development|mammotroph development|epsilon-acidophil development|lactotropic cell development|lactotrope development|mammotropic cell development|mammotrophic cell development biological_process owl:Class
GO:0060127 biolink:NamedThing prolactin secreting cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a prolactin secreting cell. A prolactin secreting cell is an acidophilic cell of the anterior pituitary that produces prolactin. got7fsn_ti epsilon-acidophil differentiation|mammotrope differentiation|mammotroph differentiation|mammotropic cell differentiation|lactotropic cell differentiation|lactotroph differentiation|lactotrope differentiation|mammotrophic cell differentiation biological_process owl:Class
GO:0036080 biolink:NamedThing purine nucleotide-sugar transmembrane transporter activity Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. got7fsn_ti bf 2011-12-19T03:29:06Z molecular_function owl:Class
GO:0090480 biolink:NamedThing purine nucleotide-sugar transmembrane transport The process in which a purine nucleotide-sugar is transported across a membrane. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. got7fsn_ti purine nucleotide-sugar membrane transport|purine nucleotide-sugar transport Note that this term is not intended for use in annotating lateral movement within membranes. tb 2011-12-19T03:22:58Z GO:0036079 biological_process owl:Class
GO:1903913 biolink:NamedThing regulation of fusion of virus membrane with host plasma membrane Any process that modulates the frequency, rate or extent of fusion of virus membrane with host plasma membrane. got7fsn_ti regulation of viral envelope fusion|regulation of viral envelope fusion with host cell membrane|regulation of viral-cell fusion molecule activity|regulation of viral envelope fusion with host membrane|regulation of viral penetration via membrane fusion|regulation of viral entry into host cell via membrane fusion with the plasma membrane|regulation of viral envelope fusion with host plasma membrane als 2015-02-09T11:13:19Z biological_process owl:Class
GO:0106084 biolink:NamedThing mitotic nuclear membrane microtubule tethering complex A protein complex capable of interacting with the spindle pole body and the nuclear envelope, in order to embed the spindle pole body in the nuclear envelope at fusion sites of the inner and outer nuclear membrane. got7fsn_ti nuclear membrane mitotic spindle pole body tethering complex|Mps2-Bbp1-Spc29 complex https://github.com/geneontology/go-ontology/issues/14829 In S. cerevisae Mps2-Bpb1 is the membrane anchor sub complex and Spc29 is the spindle pole body linker molecule. hjd 2018-01-05T19:55:37Z cellular_component owl:Class
GO:1990608 biolink:NamedThing mitotic spindle pole body localization A process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location. got7fsn_ti spindle pole body localization to nuclear envelope|spindle pole body docking|establishment and maintenance of spindle pole body localization|establishment of spindle pole body localization|establishment of spindle pole body localisation|spindle pole body localization in nuclear envelope|spindle pole body localisation in nuclear envelope|mitotic spindle pole body localization to nuclear envelope|spindle pole body positioning https://github.com/geneontology/go-ontology/issues/19149 vw 2009-05-06T02:35:32Z GO:0070632|GO:0071789 biological_process owl:Class
GO:0034971 biolink:NamedThing histone H3-R17 methylation The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone. got7fsn_ti histone H3 R17 methylation|histone lysine H3 R17 methylation|histone H3R17me biological_process owl:Class
GO:1990805 biolink:NamedThing central cylinder A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules. got7fsn_ti kmv 2015-07-17T17:48:17Z cellular_component owl:Class
GO:0110158 biolink:NamedThing calpain complex A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate. got7fsn_ti mu-calpain|M-calpain kmv 2019-07-15T18:30:51Z cellular_component owl:Class
GO:0008028 biolink:NamedThing monocarboxylic acid transmembrane transporter activity Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. got7fsn_ti prostaglandin/thromboxane transporter activity|monocarboxylate carrier GO:0008505 Reactome:R-HSA-5624211|Reactome:R-HSA-433698|Reactome:R-HSA-9645220|Reactome:R-HSA-429749 molecular_function owl:Class
GO:0015718 biolink:NamedThing monocarboxylic acid transport The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0061394 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. got7fsn_ti dph 2011-12-14T08:48:36Z biological_process owl:Class
GO:0071243 biolink:NamedThing cellular response to arsenic-containing substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. got7fsn_ti cellular response to arsenic mah 2009-12-03T02:41:05Z biological_process owl:Class
GO:0008519 biolink:NamedThing ammonium transmembrane transporter activity Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. got7fsn_ti ammonia transmembrane transporter activity GO:0051739 Reactome:R-HSA-444416|Reactome:R-HSA-444393|RHEA:28747|Reactome:R-HSA-444419|Reactome:R-HSA-446278|Reactome:R-HSA-5623051|Reactome:R-HSA-446277 molecular_function owl:Class
GO:0072488 biolink:NamedThing ammonium transmembrane transport The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. got7fsn_ti ammonium membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-12-10T10:29:57Z biological_process owl:Class
GO:0060934 biolink:NamedThing His-Purkinje system cell fate commitment The commitment of cells to His-Purkinje cell fates and their capacity to differentiate into His-Purkinje cells. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. got7fsn_ti dph 2009-09-29T01:17:00Z biological_process owl:Class
GO:0008056 biolink:NamedThing ocellus development The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects. got7fsn_ti biological_process owl:Class
GO:0015192 biolink:NamedThing L-phenylalanine transmembrane transporter activity Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid. got7fsn_ti L-phenylalanine transporter activity|L-phenylalanine permease activity molecular_function owl:Class
GO:0015823 biolink:NamedThing phenylalanine transport The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-phenylalanine transport biological_process owl:Class
GO:0021693 biolink:NamedThing cerebellar Purkinje cell layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells. got7fsn_ti cerebellar Purkinje cell layer structural organisation biological_process owl:Class
GO:0006624 biolink:NamedThing vacuolar protein processing Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes. got7fsn_ti vacuolar protein maturation|vacuolar proteolysis biological_process owl:Class
GO:0021750 biolink:NamedThing vestibular nucleus development The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0021727 biolink:NamedThing intermediate reticular formation development The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure. got7fsn_ti intermediate reticular nucleus development biological_process owl:Class
GO:0021723 biolink:NamedThing medullary reticular formation development The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata. got7fsn_ti rhombencephalic reticular formation development biological_process owl:Class
GO:0022623 biolink:NamedThing proteasome-activating nucleotidase complex A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner. got7fsn_ti PAN cellular_component owl:Class
GO:0106164 biolink:NamedThing positive regulation of exonucleolytic catabolism of deadenylated mRNA Any process that activates or increases the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. got7fsn_ti hjd 2019-01-15T15:39:19Z biological_process owl:Class
GO:0045696 biolink:NamedThing positive regulation of embryo sac egg cell differentiation Any process that activates or increases the frequency, rate or extent of embryo sac egg cell differentiation. got7fsn_ti activation of female gametophyte egg cell differentiation|up-regulation of female gametophyte egg cell differentiation|up regulation of female gametophyte egg cell differentiation|stimulation of female gametophyte egg cell differentiation|upregulation of female gametophyte egg cell differentiation|positive regulation of female gametophyte egg cell differentiation biological_process owl:Class
GO:0098772 biolink:NamedThing molecular function regulator A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20862|https://github.com/geneontology/go-ontology/issues/20854 molecular_function owl:Class
GO:0061589 biolink:NamedThing calcium activated phosphatidylserine scrambling The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. got7fsn_ti dph 2014-02-05T15:17:21Z biological_process owl:Class
GO:0061588 biolink:NamedThing calcium activated phospholipid scrambling The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. got7fsn_ti dph 2014-02-05T15:14:34Z biological_process owl:Class
GO:0050811 biolink:NamedThing GABA receptor binding Binding to a gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. got7fsn_ti 4-aminobutanoate receptor binding|4-aminobutyrate receptor binding|diazepam binding inhibitor activity|gamma-aminobutyric acid receptor binding molecular_function owl:Class
GO:0019789 biolink:NamedThing SUMO transferase activity Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. got7fsn_ti SUMO conjugating enzyme activity|SMT3 conjugating enzyme GO:0019949|GO:0016930 Reactome:R-HSA-4085994|Reactome:R-HSA-4551616|Reactome:R-HSA-4641362|Reactome:R-HSA-4085992|Reactome:R-HSA-4551768|Reactome:R-HSA-4615900|Reactome:R-HSA-4551727|Reactome:R-HSA-4655431|Reactome:R-HSA-4086083|Reactome:R-HSA-4551683|Reactome:R-HSA-4341016|Reactome:R-HSA-3000411|Reactome:R-HSA-3900047|Reactome:R-HSA-4615839|Reactome:R-HSA-4085331|Reactome:R-HSA-3000383|Reactome:R-HSA-4655440|Reactome:R-HSA-4655355|Reactome:R-HSA-4090408|Reactome:R-HSA-4090281|Reactome:R-HSA-4085372|Reactome:R-HSA-2993769|Reactome:R-HSA-4570485|Reactome:R-HSA-4717521|Reactome:R-HSA-4719436|Reactome:R-HSA-4546387|Reactome:R-HSA-3968414|Reactome:R-HSA-5684052|Reactome:R-HSA-4086059|Reactome:R-HSA-3927824|Reactome:R-HSA-3232162|Reactome:R-HSA-4719423|Reactome:R-HSA-4086036|Reactome:R-HSA-3000399|Reactome:R-HSA-2993790|Reactome:R-HSA-4570493|Reactome:R-HSA-4085296|Reactome:R-HSA-4719413|Reactome:R-HSA-4568914|Reactome:R-HSA-2997616|Reactome:R-HSA-6804468|Reactome:R-HSA-4641345|Reactome:R-HSA-3000434|Reactome:R-HSA-4090288|Reactome:R-HSA-4551661|Reactome:R-HSA-4615872|Reactome:R-HSA-3108212|Reactome:R-HSA-4551649|Reactome:R-HSA-2997706|Reactome:R-HSA-3900070|Reactome:R-HSA-4615987|Reactome:R-HSA-3968362|Reactome:R-HSA-4570553|Reactome:R-HSA-4090390|Reactome:R-HSA-4341025|Reactome:R-HSA-3108203|Reactome:R-HSA-5682607|Reactome:R-HSA-4551679|Reactome:R-HSA-4755494|Reactome:R-HSA-3900177|Reactome:R-HSA-4085347|Reactome:R-HSA-4720432|Reactome:R-HSA-5228521|Reactome:R-HSA-3234081|Reactome:R-HSA-4341072|Reactome:R-HSA-4085318|Reactome:R-HSA-3927959|Reactome:R-HSA-4570463|Reactome:R-HSA-4615889|Reactome:R-HSA-3234084|Reactome:R-HSA-3247493|Reactome:R-HSA-4551724|Reactome:R-HSA-3234094|Reactome:R-HSA-4717461|Reactome:R-HSA-4568848|Reactome:R-HSA-3000433|Reactome:R-HSA-4615873|Reactome:R-HSA-4085350|Reactome:R-HSA-5228508|Reactome:R-HSA-4615905|Reactome:R-HSA-4568863|Reactome:R-HSA-4551648|Reactome:R-HSA-3000449|Reactome:R-HSA-3927886|Reactome:R-HSA-3903017|Reactome:R-HSA-4570499|Reactome:R-HSA-4616015|Reactome:R-HSA-4570554|Reactome:R-HSA-4090284|Reactome:R-HSA-2997709|Reactome:R-HSA-4719424|Reactome:R-HSA-6790454|Reactome:R-HSA-4341073|Reactome:R-HSA-3108209|Reactome:R-HSA-4755526|Reactome:R-HSA-4568846|Reactome:R-HSA-3465545|Reactome:R-HSA-4641342|Reactome:R-HSA-4551655|Reactome:R-HSA-4341070|Reactome:R-HSA-4641350|Reactome:R-HSA-3782535|Reactome:R-HSA-4546386|Reactome:R-HSA-3296126|Reactome:R-HSA-4086088|Reactome:R-HSA-3899291|Reactome:R-HSA-4551604|Reactome:R-HSA-4546385|Reactome:R-HSA-4551738|Reactome:R-HSA-2993780|Reactome:R-HSA-4615933|Reactome:R-HSA-4551721|Reactome:R-HSA-4755411|Reactome:R-HSA-4755478|Reactome:R-HSA-6804485|Reactome:R-HSA-3000348|Reactome:R-HSA-4570496|Reactome:R-HSA-4570489|Reactome:R-HSA-4755479|Reactome:R-HSA-5228525|Reactome:R-HSA-4655374|Reactome:R-HSA-4719447|Reactome:R-HSA-2997723|Reactome:R-HSA-4720446|Reactome:R-HSA-5228523|Reactome:R-HSA-4570467|Reactome:R-HSA-4341048|Reactome:R-HSA-4615910|Reactome:R-HSA-3900194|Reactome:R-HSA-4656914|Reactome:R-HSA-4755536|Reactome:R-HSA-4570528|Reactome:R-HSA-8956365|Reactome:R-HSA-4719448 molecular_function owl:Class
GO:0106230 biolink:NamedThing protein depropionylation The removal of a propionyl group from a residue in a peptide or protein. got7fsn_ti hjd 2019-10-17T19:10:50Z biological_process owl:Class
GO:0008517 biolink:NamedThing folic acid transmembrane transporter activity Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. got7fsn_ti folate transmembrane transporter activity|vitamin M transporter activity|folate transporter activity|vitamin B9 transporter activity|folic acid transporter activity Reactome:R-HSA-200652|Reactome:R-HSA-200680|Reactome:R-HSA-200720|Reactome:R-HSA-200729|Reactome:R-HSA-200646 molecular_function owl:Class
GO:0071699 biolink:NamedThing olfactory placode morphogenesis The process in which the anatomical structures of the olfactory placode are generated and organized. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. got7fsn_ti mah 2010-03-02T12:45:45Z biological_process owl:Class
GO:0044206 biolink:NamedThing UMP salvage Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis. got7fsn_ti UMP biosynthetic process via nucleoside salvage pathway|UMP biosynthesis via nucleoside salvage pathway jl 2009-10-21T11:32:33Z biological_process owl:Class
GO:0004163 biolink:NamedThing diphosphomevalonate decarboxylase activity Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate. got7fsn_ti mevalonate pyrophosphate decarboxylase activity|pyrophosphomevalonic acid decarboxylase activity|mevalonate diphosphate decarboxylase activity|ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)|pyrophosphomevalonate decarboxylase activity|mevalonate-5-pyrophosphate decarboxylase activity|mevalonate 5-diphosphate decarboxylase activity|ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)|5-pyrophosphomevalonate decarboxylase activity KEGG_REACTION:R01121|EC:4.1.1.33|MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN|Reactome:R-HSA-191414|RHEA:23732 molecular_function owl:Class
GO:0086021 biolink:NamedThing SA node cell to atrial cardiac muscle cell communication by electrical coupling The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels. got7fsn_ti SAN cardiomyocyte to atrial cardiomyocyte communication by electrical coupling|SA node cardiac muscle cell to atrial cardiac muscle cell communication by electrical coupling|SA node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling|sinoatrial node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling|sinus node cardiomyocyte to atrial cardiomyocyte communication by electrical coupling tb 2011-11-10T09:20:39Z biological_process owl:Class
GO:0019616 biolink:NamedThing catechol catabolic process, meta-cleavage The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom. got7fsn_ti catechol breakdown, meta-cleavage|catechol degradation, meta-cleavage MetaCyc:P183-PWY biological_process owl:Class
GO:0043663 biolink:NamedThing host bacteroid-containing symbiosome A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell. got7fsn_ti cellular_component owl:Class
GO:0043658 biolink:NamedThing host symbiosome A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell. got7fsn_ti cellular_component owl:Class
GO:0002112 biolink:NamedThing interleukin-33 receptor binding Binding to an interleukin-33 receptor. got7fsn_ti IL-33|interleukin-33 receptor ligand molecular_function owl:Class
GO:0047473 biolink:NamedThing D-alanine [D-alanyl carrier protein] ligase activity Catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate. got7fsn_ti D-alanine:poly(phosphoribitol) ligase (AMP-forming)|D-alanine-activating enzyme activity|D-alanine-D-alanyl carrier protein ligase activity|D-alanine-poly(phosphoribitol) ligase activity https://github.com/geneontology/go-ontology/issues/14237 MetaCyc:6.2.1.M5-RXN|EC:6.2.1.- molecular_function owl:Class
GO:0050835 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide. got7fsn_ti RESID:AA0356 biological_process owl:Class
GO:0034397 biolink:NamedThing telomere localization Any process in which a telomere is transported to, and/or maintained in, a specific location. got7fsn_ti telomere localisation biological_process owl:Class
GO:0050000 biolink:NamedThing chromosome localization Any process in which a chromosome is transported to, or maintained in, a specific location. got7fsn_ti establishment and maintenance of chromosome localization|chromosome localisation|establishment and maintenance of chromosome position biological_process owl:Class
GO:0042052 biolink:NamedThing rhabdomere development The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments. got7fsn_ti rhabdomere organization biological_process owl:Class
GO:0035450 biolink:NamedThing extrinsic component of lumenal side of plastid thylakoid membrane The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its lumenal surface, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to lumenal leaflet of plastid thylakoid membrane|extrinsic to lumenal side of plastid thylakoid membrane|peripheral to lumenal side of plastid thylakoid membrane bf 2010-04-16T10:17:25Z cellular_component owl:Class
GO:0006361 biolink:NamedThing transcription initiation from RNA polymerase I promoter Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. got7fsn_ti transcription initiation from Pol I promoter|transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. krc 2011-08-15T03:45:49Z GO:0001180 biological_process owl:Class
GO:0045241 biolink:NamedThing cytosolic alpha-ketoglutarate dehydrogenase complex Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity. got7fsn_ti 2-oxoglutarate dehydrogenase complex cellular_component owl:Class
GO:0045240 biolink:NamedThing dihydrolipoyl dehydrogenase complex A protein complex that possesses alpha-ketoglutarate dehydrogenase activity. got7fsn_ti 2-oxoglutarate dehydrogenase complex|alpha-ketoglutarate dehydrogenase complex cellular_component owl:Class
GO:0050299 biolink:NamedThing streptomycin 3''-kinase activity Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 3''-phosphate. got7fsn_ti ATP:streptomycin 3''-phosphotransferase activity|streptomycin 3''-kinase (phosphorylating)|streptomycin 3''-phosphotransferase activity EC:2.7.1.87|RHEA:18377|KEGG_REACTION:R02227|MetaCyc:STREPTOMYCIN-3-KINASE-RXN molecular_function owl:Class
GO:0075220 biolink:NamedThing positive regulation of zoospore encystment on host Any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0010077 biolink:NamedThing maintenance of inflorescence meristem identity The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. got7fsn_ti biological_process owl:Class
GO:0050034 biolink:NamedThing L-rhamnose 1-dehydrogenase activity Catalysis of the reaction: L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + H(+) + NADH. got7fsn_ti L-rhamnofuranose:NAD+ 1-oxidoreductase activity KEGG_REACTION:R03942|EC:1.1.1.173|MetaCyc:L-RHAMNOSE-1-DEHYDROGENASE-RXN|RHEA:12649 molecular_function owl:Class
GO:0008886 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(2)O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH. got7fsn_ti dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)|D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity|nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity|glyceraldehyde-3-phosphate dehydrogenase (NADP)|glyceraldehyde phosphate dehydrogenase (NADP)|triosephosphate dehydrogenase activity|glyceraldehyde 3-phosphate dehydrogenase (NADP)|NADP-glyceraldehyde phosphate dehydrogenase|NADP-glyceraldehyde-3-phosphate dehydrogenase activity|glyceraldehyde-3-phosphate:NADP reductase activity MetaCyc:1.2.1.9-RXN|RHEA:14669|KEGG_REACTION:R01058|EC:1.2.1.9 molecular_function owl:Class
GO:0008344 biolink:NamedThing adult locomotory behavior Locomotory behavior in a fully developed and mature organism. got7fsn_ti adult locomotory behaviour See also the biological process term 'locomotory behavior ; GO:0007626'. biological_process owl:Class
GO:0140078 biolink:NamedThing class I DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. got7fsn_ti DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity|DNA-(apurinic or apyrimidinic site) lyase activity|AP endonuclease class I activity|AP site-DNA 5'-phosphomonoester-lyase activity|class I DNA-(apurinic or apyrimidinic site) lyase activity pg 2017-07-24T11:33:34Z MetaCyc:4.2.99.18-RXN|EC:4.2.99.18 molecular_function owl:Class
GO:0001858 biolink:NamedThing complement component iC3b receptor activity Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0031894 biolink:NamedThing V1A vasopressin receptor binding Binding to a V1A vasopressin receptor. got7fsn_ti V1A vasopressin receptor ligand molecular_function owl:Class
GO:0031893 biolink:NamedThing vasopressin receptor binding Binding to a vasopressin receptor. got7fsn_ti vasopressin receptor ligand molecular_function owl:Class
GO:0070385 biolink:NamedThing egasyn-beta-glucuronidase complex A protein complex that contains beta-glucuronidase and the carboxyl esterase egasyn; formation of the complex causes beta-glucuronidase to be retained in the endoplasmic reticulum. got7fsn_ti cellular_component owl:Class
GO:0000373 biolink:NamedThing Group II intron splicing The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. got7fsn_ti mRNA splicing Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. biological_process owl:Class
GO:0000377 biolink:NamedThing RNA splicing, via transesterification reactions with bulged adenosine as nucleophile Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure. got7fsn_ti lariat RNA formation|lariat RNA biosynthesis biological_process owl:Class
GO:0004042 biolink:NamedThing acetyl-CoA:L-glutamate N-acetyltransferase activity Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+). got7fsn_ti amino acid acetyltransferase activity|N-acetylglutamate synthase activity|acetylglutamate acetylglutamate synthetase activity|amino-acid N-acetyltransferase activity|AGAS KEGG_REACTION:R00259|MetaCyc:N-ACETYLTRANSFER-RXN|Reactome:R-HSA-70542|RHEA:24292|EC:2.3.1.1 molecular_function owl:Class
GO:1900614 biolink:NamedThing F-9775B biosynthetic process The chemical reactions and pathways resulting in the formation of F-9775B. got7fsn_ti F-9775B biosynthesis|F-9775B formation|F-9775B synthesis|F-9775B anabolism di 2012-05-15T07:03:32Z biological_process owl:Class
GO:0030930 biolink:NamedThing homotetrameric ADPG pyrophosphorylase complex A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species. got7fsn_ti cellular_component owl:Class
GO:0047482 biolink:NamedThing UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity Catalysis of the reaction: L-lysine + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine. got7fsn_ti UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase activity|L-lysine-adding enzyme activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)|UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase activity|uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase activity|MurE synthetase activity KEGG_REACTION:R02786|RHEA:17969|EC:6.3.2.7|MetaCyc:6.3.2.7-RXN molecular_function owl:Class
GO:0060497 biolink:NamedThing mesenchymal-endodermal cell signaling Any process that mediates the transfer of information between a mesenchymal cell and an endodermal cell. got7fsn_ti mesenchymal-endodermal cell signalling biological_process owl:Class
GO:0110152 biolink:NamedThing RNA NAD-cap (NAD-forming) hydrolase activity Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+). got7fsn_ti This reaction specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. kmv 2019-07-08T15:55:11Z RHEA:60880 molecular_function owl:Class
GO:0090586 biolink:NamedThing protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0045512 biolink:NamedThing interleukin-26 binding Binding to interleukin-26. got7fsn_ti IL-26 binding molecular_function owl:Class
GO:0032631 biolink:NamedThing interleukin-27 production The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-27 secretion|interleukin-27 formation|interleukin-27 biosynthetic process|IL-27 production|interleukin-27 synthesis GO:0045527|GO:0072625 biological_process owl:Class
GO:0004814 biolink:NamedThing arginine-tRNA ligase activity Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). got7fsn_ti arginyl-transfer ribonucleate synthetase activity|L-arginine:tRNAArg ligase (AMP-forming)|arginyl transfer ribonucleic acid synthetase activity|arginyl-tRNA synthetase activity|arginine translase activity|arginyl-transfer RNA synthetase activity|arginine-tRNA synthetase activity MetaCyc:ARGININE--TRNA-LIGASE-RXN|RHEA:20301|Reactome:R-HSA-379993|Reactome:R-HSA-380224|EC:6.1.1.19 molecular_function owl:Class
GO:0035103 biolink:NamedThing sterol regulatory element binding protein cleavage The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids. got7fsn_ti sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway|SREBP cleavage|sterol depletion response, SREBP cleavage GO:0006992 biological_process owl:Class
GO:0004504 biolink:NamedThing peptidylglycine monooxygenase activity Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. got7fsn_ti peptidylglycine alpha-hydroxylase activity|peptidylglycine alpha-amidating monooxygenase activity|peptidyl alpha-amidating enzyme activity|PAM-A|peptide-alpha-amide synthetase activity|peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)|synthase, peptide alpha-amide|peptide alpha-amide synthase activity|peptidylglycine 2-hydroxylase activity|PAM-B|PAM activity|peptide alpha-amidating enzyme EC:1.14.17.3|RHEA:21452|MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0009356 biolink:NamedThing aminodeoxychorismate synthase complex A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity. got7fsn_ti ADC synthase complex|p-aminobenzoate synthetase complex|4-amino-4-deoxychorismate synthase complex cellular_component owl:Class
GO:0090161 biolink:NamedThing Golgi ribbon formation The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. got7fsn_ti tb 2009-12-08T08:38:14Z biological_process owl:Class
GO:0007030 biolink:NamedThing Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. got7fsn_ti Golgi organisation|Golgi organization and biogenesis biological_process owl:Class
GO:2000539 biolink:NamedThing regulation of protein geranylgeranylation Any process that modulates the frequency, rate or extent of protein geranylgeranylation. got7fsn_ti regulation of protein amino acid geranylgeranylation|regulation of C-terminal protein geranylgeranylation tb 2011-03-29T06:23:05Z biological_process owl:Class
GO:0006638 biolink:NamedThing neutral lipid metabolic process The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity. got7fsn_ti neutral lipid metabolism biological_process owl:Class
GO:0000722 biolink:NamedThing telomere maintenance via recombination Any recombinational process that contributes to the maintenance of proper telomeric length. got7fsn_ti telomerase-independent telomere maintenance biological_process owl:Class
GO:0060933 biolink:NamedThing His-Purkinje system cell development The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles. got7fsn_ti dph 2009-09-29T01:15:02Z biological_process owl:Class
GO:0018394 biolink:NamedThing peptidyl-lysine acetylation The acetylation of peptidyl-lysine. got7fsn_ti biological_process owl:Class
GO:0004357 biolink:NamedThing glutamate-cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate. got7fsn_ti L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity|gamma-glutamylcysteine synthetase activity|gamma-glutamyl-L-cysteine synthetase activity|gamma-glutamylcysteinyl synthetase activity KEGG_REACTION:R00894|Reactome:R-HSA-5602892|MetaCyc:GLUTCYSLIG-RXN|Reactome:R-HSA-174367|EC:6.3.2.2|RHEA:13285 molecular_function owl:Class
GO:0101021 biolink:NamedThing estrogen 2-hydroxylase activity Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O. got7fsn_ti oestrogen 2-hydroxylase activity molecular_function owl:Class
GO:0035893 biolink:NamedThing negative regulation of platelet aggregation in other organism Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism. got7fsn_ti inhibition of platelet aggregation in other organism|down-regulation of platelet aggregation in other organism|suppression of platelet aggregation in other organism|downregulation of platelet aggregation in other organism bf 2011-06-15T02:24:43Z biological_process owl:Class
GO:0019234 biolink:NamedThing sensory perception of fast pain The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds. got7fsn_ti biological_process owl:Class
GO:0043688 biolink:NamedThing conversion of aspartyl-tRNA to asparaginyl-tRNA The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA. got7fsn_ti Note that this process has been observed in some archaeal and bacterial species. biological_process owl:Class
GO:0044507 biolink:NamedThing positive regulation of receptor activity in other organism A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism. got7fsn_ti jl 2012-02-23T04:31:52Z biological_process owl:Class
GO:0034685 biolink:NamedThing integrin alphav-beta6 complex An integrin complex that comprises one alphav subunit and one beta6 subunit. got7fsn_ti ITGAV-ITGB6 complex|alphav-beta6 integrin complex cellular_component owl:Class
GO:0050370 biolink:NamedThing tyrosine N-monooxygenase activity Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O. got7fsn_ti CYP79A1 activity|L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)|tyrosine N-hydroxylase activity RHEA:22464|MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0047171 biolink:NamedThing glucarolactone O-hydroxycinnamoyltransferase activity Catalysis of the reaction: glucarolactone + sinapoyl-CoA = O-sinapoylglucarolactone + CoA. got7fsn_ti sinapoyl-CoA:glucarolactone O-(hydroxycinnamoyl)transferase activity MetaCyc:2.3.1.132-RXN|RHEA:14261|EC:2.3.1.132 molecular_function owl:Class
GO:0050172 biolink:NamedThing phenylalanine 2-monooxygenase activity Catalysis of the reaction: L-phenylalanine + O(2) = 2-phenylacetamide + CO(2) + H(2)O. got7fsn_ti l-phenylalanine oxidase (deaminating and decarboxylating) activity|phenylalanine (deaminating, decarboxylating)oxidase activity|L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)|phenylalanine (deaminating, decarboxylating) oxidase activity|L-phenylalanine oxidase (deaminating and decarboxylating) MetaCyc:PHENYLALANINE-2-MONOOXYGENASE-RXN|RHEA:10712|KEGG_REACTION:R00690|EC:1.13.12.9 molecular_function owl:Class
GO:1990832 biolink:NamedThing slow axonal transport The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition. got7fsn_ti sl 2015-08-21T17:27:32Z biological_process owl:Class
GO:0008088 biolink:NamedThing axo-dendritic transport The directed movement of organelles or molecules along microtubules in neuron projections. got7fsn_ti axoplasmic transport|axonal transport|axon cargo transport Wikipedia:Axoplasmic_transport biological_process owl:Class
GO:0070917 biolink:NamedThing inositol phosphoceramide synthase regulator activity Binds to and modulates the activity of inositol phosphoceramide synthase. got7fsn_ti IPC synthase regulator activity See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. mah 2009-09-10T05:27:06Z molecular_function owl:Class
GO:0047620 biolink:NamedThing acylglycerol kinase activity Catalysis of the reaction: ATP + acylglycerol = ADP + acyl-sn-glycerol 3-phosphate. got7fsn_ti monoacylglycerol kinase activity|MGK|monoglyceride kinase activity|monoglyceride phosphokinase activity|monoacylglycerol kinase (phosphorylating)|ATP:acylglycerol 3-phosphotransferase activity|sn-2-monoacylglycerol kinase activity Reactome:R-HSA-5696074|RHEA:19293|EC:2.7.1.94|MetaCyc:ACYLGLYCEROL-KINASE-RXN molecular_function owl:Class
GO:0103106 biolink:NamedThing brassinolide 23-O-glucosyltransferase activity Catalysis of the reaction: brassinolide + UDP-alpha-D-glucose <=> brassinolide-23-O-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXNQT-4397 molecular_function owl:Class
GO:1990947 biolink:NamedThing exit from meiosis Any process involved in the progression from anaphase/telophase of meiosis II to the creation of end products of meiosis, in which ploidy is reduced by half. got7fsn_ti meiotic exit vw 2016-04-21T14:14:15Z biological_process owl:Class
GO:0050394 biolink:NamedThing viomycin kinase activity Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin. got7fsn_ti viomycin phosphotransferase activity|capreomycin phosphotransferase activity|ATP:viomycin O-phosphotransferase activity EC:2.7.1.103|RHEA:20509|MetaCyc:VIOMYCIN-KINASE-RXN molecular_function owl:Class
GO:0008836 biolink:NamedThing diaminopimelate decarboxylase activity Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2). got7fsn_ti DAP-decarboxylase activity|meso-2,6-diaminoheptanedioate carboxy-lyase activity|DAP decarboxylase activity|meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)|diaminopimelic acid decarboxylase activity|meso-diaminopimelate decarboxylase activity MetaCyc:DIAMINOPIMDECARB-RXN|EC:4.1.1.20|KEGG_REACTION:R00451|RHEA:15101 molecular_function owl:Class
GO:0015047 biolink:NamedThing NADPH-cytochrome-c2 reductase activity Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2. got7fsn_ti cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)|NADPH:ferricytochrome-c2 oxidoreductase activity|reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate) MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN|EC:1.6.2.5|RHEA:15237 molecular_function owl:Class
GO:0033411 biolink:NamedThing UAA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UAA codon. got7fsn_ti TAA codon-amino acid adaptor activity Note that in the standard genetic code, TAA is a stop codon (ochre) and is not normally read by a tRNA. molecular_function owl:Class
GO:0009293 biolink:NamedThing transduction The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector. got7fsn_ti Wikipedia:Transduction_(genetics) biological_process owl:Class
GO:0009292 biolink:NamedThing genetic transfer In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual. got7fsn_ti genetic exchange GO:0009292 should not be used for annotation of phage lysogeny (integration of the bacteriophage nucleic acid into the host bacterium's genome). biological_process owl:Class
GO:0070069 biolink:NamedThing cytochrome complex A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. got7fsn_ti cellular_component owl:Class
GO:0080078 biolink:NamedThing tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a tricaffeoyl spermidine molecule. got7fsn_ti dhl 2009-04-14T04:01:25Z molecular_function owl:Class
GO:0099615 biolink:NamedThing (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity Catalysis of the reaction: (R)-2-hydroxyglutarate + pyruvate = alpha-ketoglutarate + D-lactate, with FAD functioning as an intermediate hydrogen acceptor. got7fsn_ti D-2HG-pyruvate transhydrogenase activity|R-2-hydroxyglutarate alpha-pyruvate transhydrogenase activity molecular_function owl:Class
GO:0042352 biolink:NamedThing GDP-L-fucose salvage The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30). got7fsn_ti GDP-L-fucose biosynthesis, salvage pathway|GDP-L-fucose biosynthetic process, salvage pathway MetaCyc:PWY-6 biological_process owl:Class
GO:0038087 biolink:NamedThing VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGF/PDGFRalpha signaling pathway|VEGF-activated platelet-derived growth factor receptor-alpha signalling pathway|VEGF-A/PDGFRalpha signaling|vascular endothelial growth factor-activated platelet-derived growth factor receptor-alpha signaling pathway|VEGF-activated PDGFRalpha signalling pathway bf 2012-02-01T03:08:13Z biological_process owl:Class
GO:0031317 biolink:NamedThing tripartite ATP-independent periplasmic transporter complex A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients. got7fsn_ti TRAP transporter complex|TRAP-T transporter complex cellular_component owl:Class
GO:0072627 biolink:NamedThing interleukin-28A production The appearance of interleukin-28A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interferon lambda 2 production|IL-28A production|IL28A production|interleukin-28A secretion Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072628 biological_process owl:Class
GO:0034343 biolink:NamedThing type III interferon production The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far. got7fsn_ti type III interferon secretion|type III IFN production Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. This term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072644 biological_process owl:Class
GO:0035978 biolink:NamedThing histone H2A-S139 phosphorylation The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone. got7fsn_ti histone H2A.x phosphorylation at S139 Residue 1 of histone H2AX is taken as the first residue following removal of the initiating Methionine (Met). bf 2011-08-22T11:34:09Z biological_process owl:Class
GO:1990164 biolink:NamedThing histone H2A phosphorylation The modification of histone H2A by the addition of a phosphate group. got7fsn_ti mah 2013-08-08T11:13:25Z biological_process owl:Class
GO:0080081 biolink:NamedThing 4-methylumbelliferyl-beta-D-glucopyranoside beta-glucosidase activity Catalysis of the hydrolysis of glucosidic link in 4-methylumbelliferyl-beta-D-glucopyranoside. got7fsn_ti dhl 2009-04-14T04:09:06Z molecular_function owl:Class
GO:0097348 biolink:NamedThing host cell endocytic vesicle membrane The lipid bilayer surrounding a host cell endocytic vesicle. got7fsn_ti pr 2012-06-25T10:31:34Z cellular_component owl:Class
GO:0044162 biolink:NamedThing host cell cytoplasmic vesicle membrane The lipid bilayer surrounding a host cell cytoplasmic vesicle. got7fsn_ti jl 2009-08-11T04:24:02Z cellular_component owl:Class
GO:0019647 biolink:NamedThing formaldehyde assimilation via ribulose monophosphate cycle The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde. got7fsn_ti ribulose monophosphate cycle|formaldehyde assimilation via RuMP cycle MetaCyc:PWY-1861 biological_process owl:Class
GO:0021962 biolink:NamedThing vestibulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord. got7fsn_ti biological_process owl:Class
GO:0047925 biolink:NamedThing geranoyl-CoA carboxylase activity Catalysis of the reaction: ATP + bicarbonate + geranoyl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + 2 H(+) + phosphate. got7fsn_ti geranyl-CoA carboxylase activity|geranoyl-CoA:carbon-dioxide ligase (ADP-forming)|geranoyl coenzyme A carboxylase activity EC:6.4.1.5|KEGG_REACTION:R03494|UM-BBD_reactionID:r1166|MetaCyc:GERANOYL-COA-CARBOXYLASE-RXN|RHEA:17701 molecular_function owl:Class
GO:0031372 biolink:NamedThing UBC13-MMS2 complex A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p. got7fsn_ti cellular_component owl:Class
GO:0031371 biolink:NamedThing ubiquitin conjugating enzyme complex Any complex that possesses ubiquitin conjugating enzyme activity. got7fsn_ti E2 complex cellular_component owl:Class
GO:0102669 biolink:NamedThing isoflavone-7-O-glucoside beta-glucosidase activity Catalysis of the reaction: daidzein 7-O-beta-D-glucoside + H2O <=> daidzein + beta-D-glucose. got7fsn_ti MetaCyc:RXN-3591 molecular_function owl:Class
GO:0034384 biolink:NamedThing high-density lipoprotein particle clearance The process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. got7fsn_ti HDL clearance biological_process owl:Class
GO:0007473 biolink:NamedThing wing disc proximal/distal pattern formation The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing. got7fsn_ti biological_process owl:Class
GO:0007449 biolink:NamedThing proximal/distal pattern formation, imaginal disc The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed. got7fsn_ti biological_process owl:Class
GO:0036458 biolink:NamedThing hepatocyte growth factor binding Binding to a hepatocyte growth factor. got7fsn_ti HGF binding bf 2013-12-09T14:07:20Z molecular_function owl:Class
GO:0002537 biolink:NamedThing nitric oxide production involved in inflammatory response The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti production of nitric oxide involved in acute inflammatory response|production of nitric oxide involved in inflammatory response|nitric oxide production involved in acute inflammatory response biological_process owl:Class
GO:0061657 biolink:NamedThing UFM1 conjugating enzyme activity Isoenergetic transfer of UFM1 from one protein to another via the reaction X-UFM1 + Y -> Y-UFM1 + X, where both the X-UFM1 and Y-UFM1 linkages are thioester bonds between the C-terminal amino acid of UFM1 and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:35:13Z molecular_function owl:Class
GO:0070856 biolink:NamedThing myosin VI light chain binding Binding to a light chain of a myosin VI complex. got7fsn_ti mah 2009-08-13T01:46:13Z molecular_function owl:Class
GO:0035770 biolink:NamedThing ribonucleoprotein granule A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. got7fsn_ti RNP granule|mRNP granule|RNA granule bf 2011-04-01T10:50:47Z cellular_component owl:Class
GO:0008266 biolink:NamedThing poly(U) RNA binding Binding to a sequence of uracil residues in an RNA molecule. got7fsn_ti poly(U) binding molecular_function owl:Class
GO:0030698 biolink:NamedThing 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria. got7fsn_ti RUMT molecular_function owl:Class
GO:0030696 biolink:NamedThing tRNA (m5U54) methyltransferase activity Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule. got7fsn_ti RUMT Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added. molecular_function owl:Class
GO:0008697 biolink:NamedThing 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. got7fsn_ti 5-keto-4-deoxyuronate isomerase activity|4-deoxy-L-threo-5-hexulose uronate isomerase activity|4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity MetaCyc:5.3.1.17-RXN|KEGG_REACTION:R04383|EC:5.3.1.17|RHEA:23896 molecular_function owl:Class
GO:0019751 biolink:NamedThing polyol metabolic process The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. got7fsn_ti polyhydric alcohol metabolic process|polyol metabolism biological_process owl:Class
GO:0001515 biolink:NamedThing opioid peptide activity Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect. got7fsn_ti molecular_function owl:Class
GO:0044682 biolink:NamedThing archaeal-specific GTP cyclohydrolase activity Catalysis of the reaction: GTP + H2O <=> 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+. got7fsn_ti Fe(2+)-dependent archaeal-specific GTP cyclohydrolase activity|MptA activity jl 2012-08-15T11:18:40Z molecular_function owl:Class
GO:0005019 biolink:NamedThing platelet-derived growth factor beta-receptor activity Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity. got7fsn_ti betaPDGF receptor activity|PDGF beta-receptor activity molecular_function owl:Class
GO:0044097 biolink:NamedThing secretion by the type IV secretion system The controlled release of proteins or DNA by a cell, via the type IV secretion system. got7fsn_ti secretion via the type IV secretion system jl 2009-06-09T02:20:34Z biological_process owl:Class
GO:0061144 biolink:NamedThing alveolar secondary septum development The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule. got7fsn_ti dph 2010-05-25T10:43:55Z biological_process owl:Class
GO:0045431 biolink:NamedThing flavonol synthase activity Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O. got7fsn_ti flavonoid 2-oxoglutarate-dependent dioxygenase activity|FLS activity|dihydroflavonol,2-oxoglutarate:oxygen oxidoreductase activity EC:1.14.20.6|RHEA:21088 molecular_function owl:Class
GO:0008766 biolink:NamedThing UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. got7fsn_ti Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). EC:6.3.2.10|MetaCyc:UDP-NACMURALGLDAPAALIG-RXN|RHEA:28374 molecular_function owl:Class
GO:0030774 biolink:NamedThing anthranilate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:anthranilate N-methyltransferase activity|anthranilic acid N-methyltransferase activity EC:2.1.1.111|MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN|RHEA:12180|KEGG_REACTION:R00984 molecular_function owl:Class
GO:0045033 biolink:NamedThing peroxisome inheritance The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p. got7fsn_ti Note that 'vectorial' is used in the definition in the mathematical and physical sense of pertaining to 'a quantity having direction as well as magnitude, especially as determining the position of one point in space relative to another. biological_process owl:Class
GO:1990332 biolink:NamedThing Ire1 complex A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript. got7fsn_ti ERN1 complex|IRE1 dimer An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay). bhm 2014-03-17T10:46:58Z cellular_component owl:Class
GO:0052904 biolink:NamedThing N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 3-acetamidopropanal + H(2)O(2) + putrescine. got7fsn_ti polyamine oxidase activity|non-specific polyamine oxidase activity|N(1)-acetylpolyamine oxidase activity MetaCyc:RXN-9942|EC:1.5.3.13|Reactome:R-HSA-141348|Reactome:R-HSA-141351|KEGG_REACTION:R09074|EC:1.5.3.17|RHEA:25812|MetaCyc:RXN-12091 molecular_function owl:Class
GO:0031955 biolink:NamedThing short-chain fatty acid-CoA ligase activity Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6. got7fsn_ti short-chain fatty acid activation|short-chain fatty-acid-CoA ligase activity|short-chain-fatty-acid-CoA ligase activity molecular_function owl:Class
GO:0031944 biolink:NamedThing negative regulation of glucocorticoid metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. got7fsn_ti down-regulation of glucocorticoid metabolic process|downregulation of glucocorticoid metabolic process|negative regulation of glucocorticoid metabolism|inhibition of glucocorticoid metabolic process|down regulation of glucocorticoid metabolic process biological_process owl:Class
GO:0042726 biolink:NamedThing flavin-containing compound metabolic process The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. got7fsn_ti flavin-containing compound metabolism|vitamin B2 and derivative metabolic process|riboflavin and derivative metabolic process|riboflavin and derivative metabolism|vitamin B2 and derivative metabolism biological_process owl:Class
GO:0018416 biolink:NamedThing nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide. got7fsn_ti nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide RESID:AA0292 biological_process owl:Class
GO:0090059 biolink:NamedThing protoxylem development The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem. got7fsn_ti tb 2009-08-11T03:08:06Z biological_process owl:Class
GO:0099636 biolink:NamedThing cytoplasmic streaming The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains. got7fsn_ti Wikipedia:Cytoplasmic_streaming biological_process owl:Class
GO:0016482 biolink:NamedThing cytosolic transport The directed movement of substances or organelles within the cytosol. got7fsn_ti biological_process owl:Class
GO:0040029 biolink:NamedThing regulation of gene expression, epigenetic Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. got7fsn_ti biological_process owl:Class
GO:0061939 biolink:NamedThing c-di-GMP signaling Any process that mediates the transfer of information from one cell to another using c-di-GMP as the signal. got7fsn_ti cyclic di-(3':5')-guanosine monophosphate signaling|3',5'-cyclic di-GMP signaling|cyclic diguanylate signaling|cyclic di-GMP signaling dph 2017-09-14T18:59:04Z biological_process owl:Class
GO:0048348 biolink:NamedThing paraxial mesodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into a paraxial mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0034018 biolink:NamedThing ascopyrone tautomerase activity Catalysis of the reaction: 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 1,5-anhydro-4-deoxy-D-glycero-hex-1-en-3-ulose. got7fsn_ti ascopyrone intramolecular oxidoreductase activity|ascopyrone isomerase activity|1,5-anhydro-D-glycero-hex-3-en-2-ulose delta3-delta1-isomerase activity|ascopyrone P tautomerase activity|1,5-anhydro-D-glycero-hex-3-en-2-ulose tautomerase activity|APTM|APM tautomerase activity MetaCyc:5.3.3.15-RXN|EC:5.3.2.7|RHEA:22568 molecular_function owl:Class
GO:0071750 biolink:NamedThing dimeric IgA immunoglobulin complex A protein complex composed of two monomeric IgA immunoglobulin complexes linked through both direct disulfide bonds and through a disulfide binded monomer of J chain acting as a bridge. Each IgA monomer consists of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds. Dimeric IgA is sometimes complexed additionally with secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti dimeric IgA antibody|dimeric IgA1 antibody Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Dimeric IgA is by far the most common form of polymeric IgA. In human only the IgA1 isotype is capable of a dimeric form. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0033967 biolink:NamedThing box C/D RNA metabolic process The chemical reactions and pathways involving box C/D type small nucleolar RNA. got7fsn_ti box C/D sRNA metabolic process|box C/D snoRNA metabolic process https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0061711 biolink:NamedThing N(6)-L-threonylcarbamoyladenine synthase activity Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA. got7fsn_ti dph 2015-06-23T08:34:44Z EC:2.3.1.234|Reactome:R-HSA-6784494|MetaCyc:RXN-14570|RHEA:37059 molecular_function owl:Class
GO:0060855 biolink:NamedThing venous endothelial cell migration involved in lymph vessel development The orderly movement of venous endothelial cells out of the veins giving rise to the precursors of lymphatic endothelial cells. got7fsn_ti dph 2009-08-12T12:07:27Z biological_process owl:Class
GO:0043534 biolink:NamedThing blood vessel endothelial cell migration The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. got7fsn_ti biological_process owl:Class
GO:2000611 biolink:NamedThing positive regulation of thyroid hormone generation Any process that activates or increases the frequency, rate or extent of thyroid hormone generation. got7fsn_ti yaf 2011-04-18T10:12:22Z biological_process owl:Class
GO:0042541 biolink:NamedThing hemoglobin biosynthetic process The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. got7fsn_ti hemoglobin anabolism|haemoglobin biosynthesis|hemoglobin biosynthesis|hemoglobin synthesis|haemoglobin biosynthetic process|hemoglobin formation biological_process owl:Class
GO:0007628 biolink:NamedThing adult walking behavior The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg. got7fsn_ti adult walking behaviour biological_process owl:Class
GO:0003089 biolink:NamedThing positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream. got7fsn_ti increased force of heart contraction by circulating epinephrine-norepinephrine|increased force of heart contraction by circulating adrenaline-noradrenaline|positive regulation of heart contraction by circulating adrenaline-noradrenaline|increased force of heart contraction by epinephrine-norepinephrine in the blood stream|positive regulation of heart contraction by circulating epinephrine-norepinephrine biological_process owl:Class
GO:0006833 biolink:NamedThing water transport The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0043691 biolink:NamedThing reverse cholesterol transport The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. got7fsn_ti biological_process owl:Class
GO:0030301 biolink:NamedThing cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0075331 biolink:NamedThing negative regulation of arbuscule formation for nutrient acquisition from host Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont arbuscule formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0044147 biolink:NamedThing negative regulation of formation of structure involved in a symbiotic process Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. got7fsn_ti negative regulation of development of symbiont during interaction with host|negative regulation of development of symbiont involved in interaction with host https://github.com/geneontology/go-ontology/issues/20305 This term partially replaces the obsolete term 'negative regulation of growth or development of symbiont during interaction with host ; GO:0075340'. jl 2009-08-06T02:04:59Z biological_process owl:Class
GO:0102940 biolink:NamedThing phloroglucinol O-methyltransferase activity Catalysis of the reaction: phloroglucinol + S-adenosyl-L-methionine = H+ + 3,5-dihydroxyanisole + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-9020 molecular_function owl:Class
GO:0047797 biolink:NamedThing cyclohexanone dehydrogenase activity Catalysis of the reaction: A + cyclohexanone = AH(2) + cyclohex-2-enone. got7fsn_ti cyclohexanone:(acceptor) 2-oxidoreductase activity|cyclohexanone:acceptor 2-oxidoreductase activity KEGG_REACTION:R02234|EC:1.3.99.14|RHEA:21780|MetaCyc:CYCLOHEXANONE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0044551 biolink:NamedThing envenomation resulting in vasodilation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism. got7fsn_ti envenomation resulting in regulation of vasodilation in other organism|envenomation resulting in modulation of vasodilation in other organism jl 2012-03-29T02:07:45Z biological_process owl:Class
GO:0075521 biolink:NamedThing microtubule-dependent intracellular transport of viral material towards nucleus The directed movement of a virus, or part of a virus, towards the host cell nucleus using host microtubules. got7fsn_ti microtubule-dependent intracellular transport of viral material to nucleus jl 2011-08-03T02:09:21Z VZ:983 biological_process owl:Class
GO:0019618 biolink:NamedThing protocatechuate catabolic process, ortho-cleavage The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate. got7fsn_ti protocatechuate degradation, ortho-cleavage|3,4-dihydroxybenzoate catabolic process, ortho-cleavage|protocatechuate catabolic process to beta-ketoadipate|protocatechuate breakdown, ortho-cleavage MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY biological_process owl:Class
GO:0019619 biolink:NamedThing 3,4-dihydroxybenzoate catabolic process The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate. got7fsn_ti protocatechuate catabolic process|protocatechuate degradation|protocatechuate breakdown|protocatechuate catabolism biological_process owl:Class
GO:1990910 biolink:NamedThing response to hypobaric hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level). got7fsn_ti sl 2015-12-07T19:34:14Z biological_process owl:Class
GO:0098737 biolink:NamedThing protein insertion into plasma membrane The process that results in the incorporation of a protein into a plasma membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. got7fsn_ti biological_process owl:Class
GO:0051205 biolink:NamedThing protein insertion into membrane The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. got7fsn_ti membrane protein positioning|integral membrane protein positioning|protein-membrane insertion|integral membrane protein localization|membrane protein localization biological_process owl:Class
GO:0047414 biolink:NamedThing 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase activity Catalysis of the reaction: (2Z)-2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H(2)O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + CO(2) + NH(4)(+). got7fsn_ti compound B hydrolase activity|alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid hydrolase activity|2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating) RHEA:17677|KEGG_REACTION:R04397|EC:3.5.1.66|Wikipedia:2-(hydroxymethyl)-3-(acetamidomethylene)succinate_amidohydrolase_(deaminating,_decarboxylating)|MetaCyc:3.5.1.66-RXN molecular_function owl:Class
GO:1990911 biolink:NamedThing response to psychosocial stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism. got7fsn_ti sl 2015-12-07T20:38:35Z biological_process owl:Class
GO:0050418 biolink:NamedThing hydroxylamine reductase activity Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor. got7fsn_ti ammonia:(acceptor) oxidoreductase activity|ammonia:acceptor oxidoreductase activity|hydroxylamine (acceptor) reductase activity RHEA:22052|EC:1.7.99.1|MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN molecular_function owl:Class
GO:0043819 biolink:NamedThing precorrin-6A synthase (deacetylating) activity Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X. got7fsn_ti S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating)|CobF|precorrin-6X synthase (deacetylating) activity EC:2.1.1.152|RHEA:18261|MetaCyc:R322-RXN|KEGG_REACTION:R05219 molecular_function owl:Class
GO:0018946 biolink:NamedThing aerobic organosilicon metabolic process The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen. got7fsn_ti aerobic organosilicone metabolism|aerobic organosilicone metabolic process|aerobic organosilicon metabolism UM-BBD_pathwayID:osi biological_process owl:Class
GO:0018945 biolink:NamedThing organosilicon metabolic process The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon. got7fsn_ti organosilicone metabolic process|organosilicone metabolism|organosilicon metabolism UM-BBD_pathwayID:osi biological_process owl:Class
GO:0003940 biolink:NamedThing L-iduronidase activity Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate. got7fsn_ti glycosaminoglycan alpha-L-iduronohydrolase activity|alpha-L-iduronidase activity Reactome:R-HSA-9036037|MetaCyc:3.2.1.76-RXN|Reactome:R-HSA-2090037|Reactome:R-HSA-1793186|EC:3.2.1.76|Reactome:R-HSA-9036041|Reactome:R-HSA-1678716|Reactome:R-HSA-2206299 molecular_function owl:Class
GO:0048339 biolink:NamedThing paraxial mesoderm development The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube. got7fsn_ti biological_process owl:Class
GO:0018281 biolink:NamedThing GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine|GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine|GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine RESID:AA0166 biological_process owl:Class
GO:0042264 biolink:NamedThing peptidyl-aspartic acid hydroxylation The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid. got7fsn_ti peptidyl-aspartic acid/asparagine hydroxylation biological_process owl:Class
GO:0007296 biolink:NamedThing vitellogenesis The production of yolk. Yolk is a mixture of materials used for embryonic nutrition. got7fsn_ti yolk production|yolk formation Wikipedia:Vitellogenesis biological_process owl:Class
GO:0007028 biolink:NamedThing cytoplasm organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. got7fsn_ti cytoplasm organization and biogenesis|cytoplasm organisation biological_process owl:Class
GO:0045267 biolink:NamedThing proton-transporting ATP synthase, catalytic core The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. got7fsn_ti hydrogen-transporting ATP synthase, catalytic core cellular_component owl:Class
GO:0010212 biolink:NamedThing response to ionizing radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays. got7fsn_ti response to ionizing radiation stimulus|response to ionising radiation biological_process owl:Class
GO:0007110 biolink:NamedThing meiosis I cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells. got7fsn_ti cytokinesis after meiosis I biological_process owl:Class
GO:1900616 biolink:NamedThing emericellamide A catabolic process The chemical reactions and pathways resulting in the breakdown of emericellamide A. got7fsn_ti emericellamide A degradation|emericellamide A catabolism|emericellamide A breakdown di 2012-05-15T08:00:19Z biological_process owl:Class
GO:0031005 biolink:NamedThing filamin binding Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. got7fsn_ti beta-filamin binding|filamin B binding|filamin-A binding|ABPL binding|filamin C binding|ABP-278/276 binding|filamin-C binding|gamma-filamin binding|filamin-2 binding|filamin-3 binding|alpha-filamin binding|filamin-1 binding|filamin A binding|ABP-280 binding|filamin-B binding GO:0031007|GO:0031008|GO:0031006 molecular_function owl:Class
GO:1990108 biolink:NamedThing protein linear deubiquitination A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein. got7fsn_ti sp 2013-05-29T05:58:49Z biological_process owl:Class
GO:0099073 biolink:NamedThing mitochondrion-derived vesicle A vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae. got7fsn_ti MDV cellular_component owl:Class
GO:0042601 biolink:NamedThing endospore-forming forespore Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions. got7fsn_ti cellular_component owl:Class
GO:0043575 biolink:NamedThing detection of osmotic stimulus The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0001631 biolink:NamedThing cysteinyl leukotriene receptor activity Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. got7fsn_ti CysLT receptor molecular_function owl:Class
GO:0004974 biolink:NamedThing leukotriene receptor activity Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. got7fsn_ti molecular_function owl:Class
GO:0008771 biolink:NamedThing [citrate (pro-3S)-lyase] ligase activity Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form). got7fsn_ti acetate:HS-citrate lyase ligase activity|citrate lyase ligase activity|citrate (pro-3S)-lyase ligase activity|acetate: SH-acyl-carrier-protein enzyme ligase (AMP)|citrate lyase synthetase activity|acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming) MetaCyc:CITC-RXN|KEGG_REACTION:R04449|RHEA:23788|EC:6.2.1.22 molecular_function owl:Class
GO:0033863 biolink:NamedThing ribose 1,5-bisphosphate phosphokinase activity Catalysis of the reaction: D-ribose 1,5-diphosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + ADP + H(+). got7fsn_ti ATP:ribose-1,5-bisphosphate phosphotransferase activity|ribose 1,5-bisphosphokinase activity|PhnN KEGG_REACTION:R06836|RHEA:20109|EC:2.7.4.23|MetaCyc:2.7.4.23-RXN molecular_function owl:Class
GO:0051906 biolink:NamedThing maintenance of pigment granule location Any process in which a pigment granule is maintained in a location and prevented from moving elsewhere. got7fsn_ti maintenance of pigment granule localization biological_process owl:Class
GO:0052230 biolink:NamedThing modulation of intracellular transport in other organism involved in symbiotic interaction Any process in which an organism modulates the frequency, rate or extent of the directed movement of substances within the cell or cells of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modulation of intracellular trafficking in other organism|modulation of intracellular transport in other organism during symbiotic interaction biological_process owl:Class
GO:0060670 biolink:NamedThing branching involved in labyrinthine layer morphogenesis The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer. got7fsn_ti dph 2009-06-02T10:40:40Z biological_process owl:Class
GO:0000435 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter by galactose Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter. got7fsn_ti upregulation of transcription from RNA polymerase II promoter by galactose|stimulation of transcription from RNA polymerase II promoter by galactose|up-regulation of transcription from RNA polymerase II promoter by galactose|up regulation of transcription from RNA polymerase II promoter by galactose|activation of transcription from RNA polymerase II promoter by galactose biological_process owl:Class
GO:0042695 biolink:NamedThing thelarche The beginning of development of the breasts in the female. got7fsn_ti Wikipedia:Thelarche biological_process owl:Class
GO:0043796 biolink:NamedThing glyceraldehyde dehydrogenase (NADP) activity Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+. got7fsn_ti EC:1.2.1.89|RHEA:40163 molecular_function owl:Class
GO:0034046 biolink:NamedThing poly(G) binding Binding to a sequence of guanine residues in an RNA molecule. got7fsn_ti poly(rG) binding|poly(G) binding, within an RNA molecule molecular_function owl:Class
GO:0070717 biolink:NamedThing poly-purine tract binding Binding to a stretch of purines (adenine or guanine) in an RNA molecule. got7fsn_ti mah 2009-06-10T03:32:15Z molecular_function owl:Class
GO:0002292 biolink:NamedThing T cell differentiation involved in immune response The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells. got7fsn_ti T cell development involved in immune response|T lymphocyte differentiation during immune response|T-cell differentiation during immune response|T-lymphocyte differentiation during immune response|T cell differentiation during immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0036056 biolink:NamedThing filtration diaphragm A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph. got7fsn_ti bf 2011-12-12T04:36:05Z cellular_component owl:Class
GO:0031358 biolink:NamedThing intrinsic component of chloroplast outer membrane The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to chloroplast outer membrane cellular_component owl:Class
GO:0031354 biolink:NamedThing intrinsic component of plastid outer membrane The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to plastid outer membrane cellular_component owl:Class
GO:0039626 biolink:NamedThing viral intermediate capsid The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions. got7fsn_ti intermediate capsid bf 2012-07-18T04:06:25Z cellular_component owl:Class
GO:0047192 biolink:NamedThing 1-alkylglycerophosphocholine O-acetyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA. got7fsn_ti lysopaf:acetyl CoA acetyltransferase activity|blood platelet-activating factor acetyltransferase activity|1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity|platelet-activating factor-synthesizing enzyme activity|lyso-platelet-activating factor:acetyl-CoA acetyltransferase activity|lyso-platelet activating factor:acetyl-CoA acetyltransferase activity|acetyl-CoA:lyso-PAF acetyltransferase activity|acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity|acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine 2-O-acetyltransferase activity|lysoPAF:acetyl CoA acetyltransferase activity|lyso-GPC:acetyl CoA acetyltransferase activity|acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase activity|1-alkyl-2-lysolecithin acetyltransferase activity|platelet-activating factor acylhydrolase activity RHEA:18461|MetaCyc:2.3.1.67-RXN|EC:2.3.1.67 molecular_function owl:Class
GO:0021689 biolink:NamedThing cerebellar molecular layer structural organization The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells. got7fsn_ti cerebellar molecular layer structural organisation biological_process owl:Class
GO:0070893 biolink:NamedThing transposon integration Any process in which a transposable element is incorporated into another DNA molecule such as a chromosome. got7fsn_ti mah 2009-09-01T04:08:19Z biological_process owl:Class
GO:0004522 biolink:NamedThing ribonuclease A activity Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. got7fsn_ti gene S locus-specific glycoproteins|RNase I activity|endoribonuclease I|RNase activity|gene S glycoproteins|SLSG glycoproteins|ceratitis capitata alkaline ribonuclease activity|RNase A activity|pancreatic ribonuclease activity|S-genotype-assocd. glycoproteins|ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity|ribonucleic phosphatase activity|alkaline ribonuclease activity|pancreatic RNase activity|ribonuclease I activity EC:4.6.1.18|Wikipedia:Ribonuclease_A|MetaCyc:3.1.27.5-RXN molecular_function owl:Class
GO:0047917 biolink:NamedThing GDP-glucosidase activity Catalysis of the reaction: GDP-D-glucose + H(2)O = D-glucose + GDP + H(+). got7fsn_ti guanosine diphosphate D-glucose glucohydrolase activity|GDPglucose glucohydrolase activity|guanosine diphosphoglucosidase activity|GDP-glucose glucohydrolase activity|GDPglucosidase activity RHEA:15049|KEGG_REACTION:R00337|MetaCyc:GDP-GLUCOSIDASE-RXN|EC:3.2.1.42 molecular_function owl:Class
GO:0030794 biolink:NamedThing (S)-coclaurine-N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine. got7fsn_ti S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity MetaCyc:2.1.1.140-RXN|EC:2.1.1.140|RHEA:17409 molecular_function owl:Class
GO:0110154 biolink:NamedThing RNA decapping Cleavage of the 5'-cap of an RNA. got7fsn_ti kmv 2019-07-08T17:23:59Z biological_process owl:Class
GO:0060956 biolink:NamedThing endocardial cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. got7fsn_ti dph 2009-09-29T03:20:39Z biological_process owl:Class
GO:0052472 biolink:NamedThing modulation by host of symbiont transcription Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription. got7fsn_ti biological_process owl:Class
GO:1901701 biolink:NamedThing cellular response to oxygen-containing compound Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus. got7fsn_ti cellular response to oxygen molecular entity pr 2012-12-13T15:11:42Z biological_process owl:Class
GO:0060345 biolink:NamedThing spleen trabecula formation The process of creating a trabecula in the spleen. A trabecula is a tissue element in the form of a small beam, strut or rod. got7fsn_ti spleen trabecula biogenesis|spleen trabeculation biological_process owl:Class
GO:0047957 biolink:NamedThing 4'-methoxyisoflavone 2'-hydroxylase activity Catalysis of the reaction: formononetin + NADPH + O2 = 2'-hydroxyformononetin + NADP+ + H2O. got7fsn_ti isoflavone 2'-monooxygenase activity|formononetin,NADPH:oxygen oxidoreductase (2'-hydroxylating) RHEA:12388|MetaCyc:ISOFLAVONE-2-HYDROXYLASE-RXN|EC:1.14.14.89 molecular_function owl:Class
GO:0019293 biolink:NamedThing tyrosine biosynthetic process, by oxidation of phenylalanine The conversion of phenylalanine to tyrosine. got7fsn_ti tyrosine formation, by oxidation of phenylalanine|tyrosine anabolism, by oxidation of phenylalanine|tyrosine synthesis, by oxidation of phenylalanine|L-tyrosine biosynthesis IV https://github.com/geneontology/go-ontology/issues/20583 GO:0019291 MetaCyc:PWY-6134 biological_process owl:Class
GO:0051850 biolink:NamedThing acquisition of nutrients from symbiont The production of structures and/or molecules in an organism that are required for the acquisition and/or utilization of nutrients obtained from its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0019289 biolink:NamedThing rhizobactin 1021 biosynthetic process The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti. got7fsn_ti rhizobactin 1021 anabolism|rhizobactin 1021 biosynthesis|rhizobactin 1021 biosynthetic process, peptide modification|rhizobactin 1021 biosynthetic process, peptide formation|rhizobactin 1021 formation|rhizobactin 1021 synthesis GO:0031194|GO:0031193 MetaCyc:PWY-761 biological_process owl:Class
GO:0046494 biolink:NamedThing rhizobactin 1021 metabolic process The chemical reactions and pathways involving rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti. got7fsn_ti rhizobactin 1021 metabolism biological_process owl:Class
GO:0030591 biolink:NamedThing 2'-deoxyguanosine DNA ADP-ribosyltransferase activity Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form. got7fsn_ti NAD DNA ADP-ribosyltransferase activity molecular_function owl:Class
GO:0140294 biolink:NamedThing NAD DNA ADP-ribosyltransferase activity Catalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. got7fsn_ti pg 2018-11-22T15:45:35Z molecular_function owl:Class
GO:0039596 biolink:NamedThing modulation by virus of host protein dephosphorylation Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein. got7fsn_ti bf 2012-07-19T11:46:23Z biological_process owl:Class
GO:0021939 biolink:NamedThing extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation. got7fsn_ti extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation biological_process owl:Class
GO:0035426 biolink:NamedThing extracellular matrix-cell signaling Any process that mediates the transfer of information between the extracellular matrix and a cell. got7fsn_ti cell-extracellular matrix signalling|extracellular matrix-cell signalling bf 2010-03-29T02:26:54Z biological_process owl:Class
GO:0030126 biolink:NamedThing COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. got7fsn_ti coatomer GO:0017167 cellular_component owl:Class
GO:0019163 biolink:NamedThing pyridoxamine-phosphate transaminase activity Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate. got7fsn_ti pyridoxamine phosphate aminotransferase activity|pyridoxamine-phosphate aminotransferase activity|pyridoxamine 5'-phosphate transaminase activity|pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity|pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming) RHEA:15877|MetaCyc:PYRDAMPTRANS-RXN|EC:2.6.1.54 molecular_function owl:Class
GO:0019146 biolink:NamedThing arabinose-5-phosphate isomerase activity Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+). got7fsn_ti arabinose phosphate isomerase activity|D-arabinose-5-phosphate aldose-ketose-isomerase activity|D-arabinose-5-phosphate ketol-isomerase activity|phosphoarabinoisomerase activity MetaCyc:DARAB5PISOM-RXN|RHEA:23104|KEGG_REACTION:R01530|EC:5.3.1.13 molecular_function owl:Class
GO:0061361 biolink:NamedThing positive regulation of maintenance of bipolar cell polarity regulating cell shape Any process that increases the frequency, rate or extent of maintenance of bipolar cell polarity regulating cell shape. got7fsn_ti dph 2010-10-13T09:00:59Z biological_process owl:Class
GO:2000247 biolink:NamedThing positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. got7fsn_ti vw 2010-11-11T11:39:34Z biological_process owl:Class
GO:0052576 biolink:NamedThing carbohydrate storage The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. got7fsn_ti 2010-07-23T04:16:56Z biological_process owl:Class
GO:0052575 biolink:NamedThing carbohydrate localization Any process in which a carbohydrate is transported to, or maintained in, a specific location. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. got7fsn_ti carbohydrate localisation 2010-07-23T04:08:13Z biological_process owl:Class
GO:0102385 biolink:NamedThing patchoulol synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> seychellene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-13522 molecular_function owl:Class
GO:0102474 biolink:NamedThing eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 6C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP + H+. got7fsn_ti MetaCyc:RXN-14080 molecular_function owl:Class
GO:0007264 biolink:NamedThing small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. got7fsn_ti small GTPase-mediated signal transduction biological_process owl:Class
GO:0010241 biolink:NamedThing ent-kaurene oxidation to kaurenoic acid The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase. got7fsn_ti ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase|ent-kaurene oxidation to ent-kaurenoate|ent-kaurene oxidation to ent-kaur-16-en-19-oate Note that this term was in molecular function but was moved to biological process as it represents three successive reactions. biological_process owl:Class
GO:0033331 biolink:NamedThing ent-kaurene metabolic process The chemical reactions and pathways involving ent-kaur-16-ene. Ent-kaurene is a tetracyclic diterpenoid that is a precursor of several plant isoprenoids, including gibberellins. got7fsn_ti ent-kaurene metabolism biological_process owl:Class
GO:0043743 biolink:NamedThing LPPG:FO 2-phospho-L-lactate transferase activity Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP. got7fsn_ti EC:2.7.8.28|RHEA:27510 molecular_function owl:Class
GO:0070475 biolink:NamedThing rRNA base methylation The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0052734 biolink:NamedThing shikimate 3-dehydrogenase (NAD+) activity Catalysis of the reaction: shikimate + NAD+ = 3-dehydroshikimate + NADH + H+. got7fsn_ti DHS reductase activity|shikimate:NAD(P)(+) 3-oxidoreductase activity|shikimate oxidoreductase activity|dehydroshikimic reductase activity|shikimate:NAD(P)(+) oxidoreductase activity|3-dehydroshikimic reductase activity|3-dehydroshikimate reductase activity ai 2011-08-16T04:28:23Z RHEA:17741|KEGG_REACTION:R06847|EC:1.1.1.282 molecular_function owl:Class
GO:0070023 biolink:NamedThing interleukin-12-interleukin-12 receptor complex A protein complex that is formed by the association of a heterodimeric interleukin-12 receptor complex with an interleukin-12 heterodimer. got7fsn_ti IL12-IL12 receptor complex|IL12B-IL12RB1-IL12RB2 complex cellular_component owl:Class
GO:0071764 biolink:NamedThing nuclear outer membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane. got7fsn_ti nuclear outer membrane organisation|nuclear outer membrane organization and biogenesis mah 2010-03-29T04:03:37Z biological_process owl:Class
GO:0018673 biolink:NamedThing anthraniloyl-CoA monooxygenase activity Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+. got7fsn_ti 2-aminobenzoyl-CoA monooxygenase/reductase activity|anthraniloyl coenzyme A reductase activity|2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing) EC:1.14.13.40|MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN|UM-BBD_reactionID:r0568 molecular_function owl:Class
GO:0030641 biolink:NamedThing regulation of cellular pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment. got7fsn_ti cellular hydrogen ion homeostasis|proton homeostasis biological_process owl:Class
GO:1901685 biolink:NamedThing glutathione derivative metabolic process The chemical reactions and pathways involving glutathione derivative. got7fsn_ti glutathione derivative metabolism pr 2012-12-05T11:57:11Z biological_process owl:Class
GO:0035963 biolink:NamedThing cellular response to interleukin-13 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus. got7fsn_ti cellular response to IL-13 bf 2011-08-01T11:29:42Z biological_process owl:Class
GO:0048029 biolink:NamedThing monosaccharide binding Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. got7fsn_ti molecular_function owl:Class
GO:0061204 biolink:NamedThing paramyosin filament assembly or disassembly The formation or disassembly of a filament composed of paramyosin molecules. got7fsn_ti dph 2010-07-29T12:26:38Z biological_process owl:Class
GO:0043077 biolink:NamedThing initiation of acetate catabolic process The activation of the chemical reactions and pathways resulting in the breakdown of acetate. got7fsn_ti initiation of acetate catabolism|initiation of acetate degradation|initiation of acetate breakdown biological_process owl:Class
GO:0045754 biolink:NamedThing positive regulation of acetate catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate. got7fsn_ti activation of acetate catabolic process|positive regulation of acetate catabolism|positive regulation of acetate degradation|upregulation of acetate catabolic process|up-regulation of acetate catabolic process|stimulation of acetate catabolic process|up regulation of acetate catabolic process|positive regulation of acetate breakdown biological_process owl:Class
GO:0048541 biolink:NamedThing Peyer's patch development The process whose specific outcome is the progression of Peyer's patches over time, from their formation to the mature structure. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes. got7fsn_ti gut-associated lymphoid tissue development|GALT development biological_process owl:Class
GO:0048537 biolink:NamedThing mucosa-associated lymphoid tissue development The process whose specific outcome is the progression of mucosal-associated lymphoid tissue over time, from its formation to the mature structure. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes. got7fsn_ti NALT development|nasopharyngeal-associated lymphoid tissue development|mucosal-associated lymphoid tissue development|GALT development|BALT development|bronchial-associated lymphoid tissue development|gut-associated lymphoid tissue development https://github.com/geneontology/go-ontology/issues/19918 biological_process owl:Class
GO:0050467 biolink:NamedThing pentalenene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene. got7fsn_ti pentalenene synthetase activity|2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, pentalenene-forming)|2-trans,6-trans-farnesyldiphosphate diphosphate-lyase (cyclizing, pentalenene-forming) EC:4.2.3.7|RHEA:18081|MetaCyc:PENTALENENE-SYNTHASE-RXN|KEGG_REACTION:R02305 molecular_function owl:Class
GO:0033801 biolink:NamedThing vitexin 2''-O-rhamnoside 7-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + vitexin 2''-O-beta-L-rhamnoside = S-adenosyl-L-homocysteine + 7-O-methylvitexin 2''-O-beta-L-rhamnoside. got7fsn_ti S-adenosyl-L-methionine:vitexin-2''-O-beta-L-rhamnoside 7-O-methyltransferase activity EC:2.1.1.153|RHEA:11432|MetaCyc:RXN-4981 molecular_function owl:Class
GO:1990749 biolink:NamedThing polynucleotide adenylyltransferase activator activity Increases the activity of the enzyme polynucleotide adenylyltransferase. got7fsn_ti kmv 2015-05-19T15:02:39Z molecular_function owl:Class
GO:0019736 biolink:NamedThing peptidyl-sarcosine incorporation The incorporation of sarcosine (N-methylglycine) into non-coded peptides. got7fsn_ti RESID:AA0063 biological_process owl:Class
GO:0035130 biolink:NamedThing post-embryonic pectoral fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion. got7fsn_ti biological_process owl:Class
GO:0097520 biolink:NamedThing nucleotide-excision repair, preincision complex A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. got7fsn_ti UvrA(2)-UvrB(2) complex|UvrA(2)B(2) complex|UvrB dimer pr 2013-10-17T14:32:37Z cellular_component owl:Class
GO:0003862 biolink:NamedThing 3-isopropylmalate dehydrogenase activity Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+. got7fsn_ti 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity|IMDH activity|IPMDH|beta-IPM dehydrogenase activity|beta-isopropylmalic enzyme|(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity|threo-Ds-3-isopropylmalate dehydrogenase activity|beta-isopropylmalate dehydrogenase activity RHEA:32271|EC:1.1.1.85|MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN molecular_function owl:Class
GO:0030792 biolink:NamedThing methylarsonite methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate. got7fsn_ti Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137). EC:2.1.1.-|MetaCyc:2.1.1.138-RXN molecular_function owl:Class
GO:0052623 biolink:NamedThing ADP dimethylallyltransferase activity Catalysis of the reaction: delta2-isopentenyl diphosphate + ADP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-diphosphate. got7fsn_ti dimethylallyl-diphosphate:ADP dimethylallyltransferase activity|ADP isopentenyltransferase activity|2-isopentenyl-diphosphate:ADP delta2-isopentenyltransferase activity|2-isopentenyl-diphosphate:ADP 2-isopentenyltransferase activity ai 2010-08-26T10:45:44Z KEGG_REACTION:R08051|MetaCyc:RXN-4305|EC:2.5.1.- molecular_function owl:Class
GO:0098817 biolink:NamedThing evoked excitatory postsynaptic potential A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell induced by the evoked release of many vesicles of excitatory neurotransmitter at the synapse. got7fsn_ti biological_process owl:Class
GO:0060079 biolink:NamedThing excitatory postsynaptic potential A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. got7fsn_ti regulation of excitatory post-synaptic membrane potential|regulation of EPSP biological_process owl:Class
GO:0015846 biolink:NamedThing polyamine transport The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0071117 biolink:NamedThing alpha5-beta1 integrin-fibronectin-NOV complex A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and the extracellular matrix protein NOV. got7fsn_ti ITGA5-ITGB1-FN-1-NOV complex mah 2009-11-13T02:19:52Z cellular_component owl:Class
GO:0052381 biolink:NamedThing tRNA dimethylallyltransferase activity Catalysis of the reaction: dimethylallyl diphosphate + tRNA = diphosphate + tRNA containing 6-dimethylallyladenosine. got7fsn_ti tRNA prenyltransferase activity|tRNA isopentenyltransferase activity|dimethylallyl-diphosphate:tRNA dimethylallyltransferase activity Note that this activity was formerly know in GO and EC as 'tRNA isopentenyltransferase' (EC:2.5.1.8, GO:0004811), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate. 2010-07-23T03:07:33Z GO:0004811 Reactome:R-HSA-6787567|EC:2.5.1.75|MetaCyc:RXN0-6274|RHEA:26482|Reactome:R-HSA-6784462 molecular_function owl:Class
GO:0035298 biolink:NamedThing regulation of Malpighian tubule size Ensuring that a Malpighian tubule is the correct length and diameter. got7fsn_ti biological_process owl:Class
GO:0035150 biolink:NamedThing regulation of tube size Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes. got7fsn_ti biological_process owl:Class
GO:0004471 biolink:NamedThing malate dehydrogenase (decarboxylating) (NAD+) activity Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. got7fsn_ti NAD-linked malic enzyme|(S)-malate:NAD+ oxidoreductase (decarboxylating)|NAD-malic enzyme activity|(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)|NAD-specific malic enzyme|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|'malic' enzyme For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'. GO:0016619|GO:0004472 RHEA:12653|MetaCyc:MALIC-NAD-RXN|EC:1.1.1.39|Reactome:R-HSA-9012268|MetaCyc:1.1.1.39-RXN|KEGG_REACTION:R00214|EC:1.1.1.38 molecular_function owl:Class
GO:0043387 biolink:NamedThing mycotoxin catabolic process The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus. got7fsn_ti mycotoxin catabolism|mycotoxin breakdown|mycotoxin degradation biological_process owl:Class
GO:0009631 biolink:NamedThing cold acclimation Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures. got7fsn_ti biological_process owl:Class
GO:0070678 biolink:NamedThing preprotein binding Binding to a preprotein, the unprocessed form of a protein destined to undergo co- or post-translational processing. got7fsn_ti unprocessed protein binding mah 2009-05-29T03:41:54Z molecular_function owl:Class
GO:0071480 biolink:NamedThing cellular response to gamma radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. got7fsn_ti cellular response to gamma ray|cellular response to gamma-ray photon mah 2009-12-18T02:00:50Z biological_process owl:Class
GO:0010332 biolink:NamedThing response to gamma radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. got7fsn_ti response to gamma ray|response to gamma-ray photon biological_process owl:Class
GO:0008057 biolink:NamedThing eye pigment granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye. got7fsn_ti eye pigment granule organization and biogenesis|eye pigment granule organisation GO:0008059|GO:0045318|GO:0048751 biological_process owl:Class
GO:0102118 biolink:NamedThing gibberellin A4 carboxyl methyltransferase activity Catalysis of the reaction: gibberellin A4 + S-adenosyl-L-methionine <=> gibberellin A4 methyl ester + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:36107|EC:2.1.1.276|MetaCyc:RXN-11359 molecular_function owl:Class
GO:0030281 biolink:NamedThing structural constituent of cutaneous appendage The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers. got7fsn_ti molecular_function owl:Class
GO:0061498 biolink:NamedThing intermediate layer of mitotic spindle pole body Structure between the central and outer plaques of the mitotic spindle pole body. got7fsn_ti dph 2012-12-11T09:17:14Z cellular_component owl:Class
GO:0102267 biolink:NamedThing tRNA-dihydrouridine20b synthase activity Catalysis of the reaction: a 5,6-dihydrouracil20b in tRNA + NAD(P) <=> H+ + a uracil20b in tRNA + NAD(P)H. got7fsn_ti MetaCyc:RXN-12476 molecular_function owl:Class
GO:0090116 biolink:NamedThing C-5 methylation of cytosine The covalent transfer of a methyl group to C-5 of cytosine in a DNA molecule. got7fsn_ti tb 2009-12-07T11:58:47Z biological_process owl:Class
GO:0021862 biolink:NamedThing early neuron differentiation in forebrain The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0051777 biolink:NamedThing ent-kaurenoate oxidase activity Catalysis of the reaction: ent-kaurenoate + NADPH + O2 = ent-7-alpha-hydroxykaurenoate + NADP+ + H2O. This is the first of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). got7fsn_ti ent-kaur-16-en-19-oate,NADPH:oxygen oxidoreductase (hydroxylating) activity|ent-kaurenoic acid oxidase activity Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778' and 'gibberellin 12-aldehyde oxidase activity ; GO:0051779'. RHEA:19241|MetaCyc:1.14.13.79-RXN molecular_function owl:Class
GO:0060095 biolink:NamedThing zinc potentiation of synaptic transmission, glycinergic Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission in the presence of zinc. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. got7fsn_ti zinc potentiation of glycinergic synaptic transmission biological_process owl:Class
GO:0060094 biolink:NamedThing positive regulation of synaptic transmission, glycinergic Any process that activates or increases the frequency, rate or extent of glycinergic synaptic transmission. Glycinergic synaptic transmission is the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glycine. got7fsn_ti positive regulation of glycinergic synaptic transmission biological_process owl:Class
GO:0034550 biolink:NamedThing dimethylarsinate reductase activity Catalysis of the reaction: dimethylarsinate + 3 H+ + 2 e- = dimethylarsinous acid + H2O. got7fsn_ti UM-BBD_reactionID:r0838|EC:1.97.1.- molecular_function owl:Class
GO:0032218 biolink:NamedThing riboflavin transport The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. got7fsn_ti biological_process owl:Class
GO:0004855 biolink:NamedThing xanthine oxidase activity Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide. got7fsn_ti xanthine:xanthine oxidase activity|schardinger enzyme|hypoxanthine-xanthine oxidase activity|Schardinger enzyme activity|xanthine:O(2) oxidoreductase activity|xanthine:oxygen oxidoreductase activity|xanthine oxidoreductase activity|xanthine:O2 oxidoreductase activity MetaCyc:XANTHINE-OXIDASE-RXN|Reactome:R-HSA-74247|EC:1.17.3.2|Reactome:R-HSA-74258|UM-BBD_enzymeID:e0781|RHEA:21132 molecular_function owl:Class
GO:0044184 biolink:NamedThing host cell late endosome A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center. got7fsn_ti jl 2009-10-15T02:58:34Z cellular_component owl:Class
GO:0044879 biolink:NamedThing mitotic morphogenesis checkpoint signaling A signaling process that contributes to a mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth. got7fsn_ti signal transduction involved in septin checkpoint|signalling pathway involved in morphogenesis checkpoint|signaling pathway involved in morphogenesis checkpoint|signalling cascade involved in septin checkpoint|septin checkpoint|signaling cascade involved in morphogenesis checkpoint|morphogenesis checkpoint|signalling cascade involved in morphogenesis checkpoint|signalling pathway involved in septin checkpoint|signaling pathway involved in septin checkpoint|signaling cascade involved in septin checkpoint|signal transduction involved in morphogenesis checkpoint https://github.com/geneontology/go-ontology/issues/20935 jl 2015-01-13T16:03:07Z GO:1903822 biological_process owl:Class
GO:0019954 biolink:NamedThing asexual reproduction The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process. got7fsn_ti parthenogenesis Wikipedia:Asexual_reproduction biological_process owl:Class
GO:0004336 biolink:NamedThing galactosylceramidase activity Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. got7fsn_ti galactosylceramide beta-galactosidase activity|galactosylcerebrosidase activity|galactocerebroside-beta-D-galactosidase activity|galactocerebroside beta-galactosidase activity|galactosylceramidase I|galactocerebrosidase activity|beta-galactocerebrosidase activity|lactosylceramidase I|D-galactosyl-N-acylsphingosine galactohydrolase activity|ceramide galactosidase activity|beta-galactosylceramidase activity|lactosylceramidase activity|cerebroside beta-galactosidase activity|galactocerebroside galactosidase activity|galcerase activity|cerebroside galactosidase activity EC:3.2.1.46|MetaCyc:GALACTOSYLCERAMIDASE-RXN|RHEA:14297|Reactome:R-HSA-1606564 molecular_function owl:Class
GO:0030843 biolink:NamedThing negative regulation of intermediate filament depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization. got7fsn_ti inhibition of intermediate filament depolymerization|down regulation of intermediate filament depolymerization|down-regulation of intermediate filament depolymerization|negative regulation of intermediate filament polymerization and/or depolymerization|downregulation of intermediate filament depolymerization Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840'). biological_process owl:Class
GO:0070312 biolink:NamedThing RAD52-ERCC4-ERCC1 complex A nucleotide-excision repair complex formed by the association of the heterodimeric endonuclease XPF/ERCC4-ERCC1 (Rad1p and Rad10p in S. cerevisiae) with the RAD52 protein. got7fsn_ti Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. cellular_component owl:Class
GO:0032129 biolink:NamedThing histone deacetylase activity (H3-K9 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. got7fsn_ti molecular_function owl:Class
GO:0030835 biolink:NamedThing negative regulation of actin filament depolymerization Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization. got7fsn_ti actin filament stabilization|downregulation of actin filament depolymerization|inhibition of actin filament depolymerization|negative regulation of actin depolymerization|negative regulation of actin polymerization and/or depolymerization|down-regulation of actin filament depolymerization|down regulation of actin filament depolymerization Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837'). GO:0030044 biological_process owl:Class
GO:0102899 biolink:NamedThing dehydroabietadienol hydroxylase activity Catalysis of the reaction: H+ + dehydroabietadienol + NADPH + O2 <=> dehydroabietadiene-diol + NADP + H2O. got7fsn_ti MetaCyc:RXN-8532 molecular_function owl:Class
GO:1900607 biolink:NamedThing tensidol B catabolic process The chemical reactions and pathways resulting in the breakdown of tensidol B. got7fsn_ti tensidol B degradation|tensidol B catabolism|tensidol B breakdown di 2012-05-15T06:58:43Z biological_process owl:Class
GO:0106319 biolink:NamedThing (R)-limonene 1,2-monooxygenase NADH activity Catalysis of the reaction: (4R)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4R)-limonene-1,2-epoxide. got7fsn_ti hjd 2020-09-23T15:20:27Z RHEA:26093|EC:1.14.13.107 molecular_function owl:Class
GO:0072029 biolink:NamedThing long nephron development The process whose specific outcome is the progression of a long nephron over time, from its formation to the mature structure. Long nephrons are associated with juxtamedullary glomeruli and extend into the inner medulla. got7fsn_ti juxtamedullary nephron development mah 2010-01-25T02:49:08Z biological_process owl:Class
GO:0035724 biolink:NamedThing CD24 biosynthetic process The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation. got7fsn_ti CD24 anabolism|CD24 synthesis|CD24 biosynthesis|CD24 formation bf 2011-03-07T11:32:54Z biological_process owl:Class
GO:0052155 biolink:NamedThing modulation by symbiont of host cell-mediated immune response Any process in which an organism modulates the frequency, rate or extent of any form of cell-based immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of cell-mediated immune response of other organism involved in symbiotic interaction|modulation by organism of host cell-based immune response GO:0052294 biological_process owl:Class
GO:0060521 biolink:NamedThing mesenchymal-epithelial cell signaling involved in prostate induction Signaling at short range from urogenital sinus mesenchymal cells to cells of the urogenital epithelium resulting in the epithelial cells adopting a prostatic fate. got7fsn_ti mesenchymal-epithelial cell signalling involved in prostate induction biological_process owl:Class
GO:0060739 biolink:NamedThing mesenchymal-epithelial cell signaling involved in prostate gland development Any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time. got7fsn_ti mesenchymal-epithelial cell signalling involved in prostate gland development dph 2009-06-15T09:35:08Z biological_process owl:Class
GO:0051275 biolink:NamedThing beta-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of beta-glucans. got7fsn_ti beta-glucan catabolism|beta-glucan degradation|beta-glucan breakdown biological_process owl:Class
GO:0031072 biolink:NamedThing heat shock protein binding Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. got7fsn_ti molecular_function owl:Class
GO:0035513 biolink:NamedThing oxidative RNA demethylation The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms. got7fsn_ti bf 2010-04-30T02:25:35Z biological_process owl:Class
GO:0033813 biolink:NamedThing deacetylcephalosporin-C acetyltransferase activity Catalysis of the reaction: acetyl-CoA + deacetylcephalosporin C = cephalosporin C + CoA. got7fsn_ti CPC acetylhydrolase activity|acetyl-CoA:DAC O-acetyltransferase activity|cefG|acetyl-CoA:deacetylcephalosporin-C acetyltransferase activity|acetyl coenzyme A:DAC acetyltransferase activity|acetyl-CoA:deacetylcephalosporin-C O-acetyltransferase activity|acetyl-CoA:DAC acetyltransferase activity|DAC-AT|deacetylcephalosporin C acetyltransferase activity|DAC acetyltransferase activity KEGG_REACTION:R03064|RHEA:23860|EC:2.3.1.175|MetaCyc:2.3.1.175-RXN molecular_function owl:Class
GO:0030987 biolink:NamedThing high molecular weight kininogen receptor binding Binding to a high molecular weight kininogen receptor. got7fsn_ti molecular_function owl:Class
GO:0002345 biolink:NamedThing peripheral B cell receptor editing The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation. got7fsn_ti peripheral B lymphocyte receptor editing|peripheral B-lymphocyte receptor editing|peripheral B-cell receptor editing biological_process owl:Class
GO:0043101 biolink:NamedThing purine-containing compound salvage Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis. got7fsn_ti purine salvage biological_process owl:Class
GO:0044015 biolink:NamedThing histone acetyltransferase activity (H2B-K12 specific) Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12). got7fsn_ti histone lysine N-acetyltransferase activity (H2B-K12 specific) molecular_function owl:Class
GO:0015630 biolink:NamedThing microtubule cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. got7fsn_ti cellular_component owl:Class
GO:1900594 biolink:NamedThing (+)-kotanin metabolic process The chemical reactions and pathways involving (+)-kotanin. got7fsn_ti (+)-kotanin metabolism di 2012-05-15T06:54:19Z biological_process owl:Class
GO:0045003 biolink:NamedThing double-strand break repair via synthesis-dependent strand annealing SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break. got7fsn_ti mitotic gene conversion|SDSA biological_process owl:Class
GO:0003756 biolink:NamedThing protein disulfide isomerase activity Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. got7fsn_ti protein disulfide-isomerase reaction|protein disulfide-isomerase|protein cysteine-thiol oxidation|disulphide bond formation|protein thiol-disulfide exchange|S-S rearrangase activity|protein thiol-disulphide exchange|disulphide bond biosynthesis|protein disulphide isomerase activity GO:0006467 MetaCyc:5.3.4.1-RXN|EC:5.3.4.1|Reactome:R-HSA-8950183|Reactome:R-HSA-8950456|Reactome:R-HSA-8950113 molecular_function owl:Class
GO:0045144 biolink:NamedThing meiotic sister chromatid segregation The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle. got7fsn_ti meiosis II, chromosome segregation biological_process owl:Class
GO:0102038 biolink:NamedThing 4-nitrobenzyl alcohol oxidase activity Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 <=> 4-nitrobenzaldehyde + hydrogen peroxide. got7fsn_ti MetaCyc:R362-RXN molecular_function owl:Class
GO:0016611 biolink:NamedThing iron-iron nitrogenase complex An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen. got7fsn_ti Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells. cellular_component owl:Class
GO:0016610 biolink:NamedThing nitrogenase complex An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen. got7fsn_ti cellular_component owl:Class
GO:0046218 biolink:NamedThing indolalkylamine catabolic process The chemical reactions and pathways resulting in the breakdown of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. got7fsn_ti indolalkylamine breakdown|indolalkylamine degradation|indolalkylamine catabolism biological_process owl:Class
GO:0047048 biolink:NamedThing 3-hydroxybenzyl-alcohol dehydrogenase activity Catalysis of the reaction: 3-hydroxybenzyl alcohol + NADP(+) = 3-hydroxybenzaldehyde + H(+) + NADPH. got7fsn_ti 3-hydroxybenzyl-alcohol:NADP+ oxidoreductase activity|m-hydroxybenzylalcohol dehydrogenase activity|m-hydroxybenzyl alcohol (NADP) dehydrogenase activity|m-hydroxybenzyl alcohol dehydrogenase activity RHEA:22340|MetaCyc:1.1.1.97-RXN|KEGG_REACTION:R04136|EC:1.1.1.97 molecular_function owl:Class
GO:0036323 biolink:NamedThing vascular endothelial growth factor receptor-1 signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGFR1 signaling pathway|VEGFR-1 signaling pathway|FLT1 signaling pathway bf 2012-09-04T15:11:21Z biological_process owl:Class
GO:0006531 biolink:NamedThing aspartate metabolic process The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. got7fsn_ti aspartate metabolism biological_process owl:Class
GO:0010202 biolink:NamedThing response to low fluence red light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec. got7fsn_ti biological_process owl:Class
GO:0009645 biolink:NamedThing response to low light intensity stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2. got7fsn_ti biological_process owl:Class
GO:0045577 biolink:NamedThing regulation of B cell differentiation Any process that modulates the frequency, rate or extent of B cell differentiation. got7fsn_ti regulation of B lymphocyte differentiation|regulation of B-cell differentiation|regulation of B cell development|regulation of B-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0005007 biolink:NamedThing fibroblast growth factor-activated receptor activity Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti fibroblast growth factor receptor activity|FGF receptor activity|FGF-activated receptor activity|FGFR Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand FGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class
GO:0019344 biolink:NamedThing cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. got7fsn_ti cysteine anabolism|cysteine formation|cysteine synthesis|cysteine biosynthesis biological_process owl:Class
GO:0043034 biolink:NamedThing costamere Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. got7fsn_ti Wikipedia:Costamere cellular_component owl:Class
GO:0036259 biolink:NamedThing aerobic raffinose catabolic process The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen. got7fsn_ti aerobic raffinose catabolism|aerobic raffinose degradation|aerobic raffinose breakdown bf 2012-06-15T01:14:51Z biological_process owl:Class
GO:0034484 biolink:NamedThing raffinose catabolic process The chemical reactions and pathways resulting in the breakdown of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. got7fsn_ti raffinose degradation|raffinose breakdown|raffinose catabolism biological_process owl:Class
GO:0099099 biolink:NamedThing G-protein gated ion channel activity An ion channel activity that is gated by binding of a G-protein beta-gamma dimer. got7fsn_ti molecular_function owl:Class
GO:0050912 biolink:NamedThing detection of chemical stimulus involved in sensory perception of taste The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal. got7fsn_ti sensory detection of chemical stimulus during perception of taste|perception of taste, sensory detection of chemical stimulus|perception of taste, sensory transduction of chemical stimulus|sensory transduction of taste|sensory transduction of chemical stimulus during perception of taste|sensory detection of taste|perception of taste, detection of chemical stimulus|taste perception biological_process owl:Class
GO:0050239 biolink:NamedThing pyrithiamine deaminase activity Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3. got7fsn_ti 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium-bromide aminohydrolase activity MetaCyc:PYRITHIAMIN-DEAMINASE-RXN|EC:3.5.4.20|RHEA:14537 molecular_function owl:Class
GO:0017119 biolink:NamedThing Golgi transport complex A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. Composed of 8 subunits COG1-8. got7fsn_ti COG complex|conserved oligomeric Golgi complex|Sec34/35 complex cellular_component owl:Class
GO:0042657 biolink:NamedThing MHC class II protein binding, via lateral surface Binding to the lateral surface of major histocompatibility complex class II molecules. got7fsn_ti major histocompatibility complex class II protein binding, via lateral surface molecular_function owl:Class
GO:0042289 biolink:NamedThing MHC class II protein binding Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. got7fsn_ti major histocompatibility complex class II binding|major histocompatibility complex class II ligand Note that this term does not include binding to the antigen peptide bound to the MHC protein. Consider also annotating to the molecular function term 'peptide antigen binding ; GO:0042605' or one of its children. molecular_function owl:Class
GO:0008139 biolink:NamedThing nuclear localization sequence binding Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. got7fsn_ti NLS binding|nuclear localization signal binding|nuclear localisation sequence binding molecular_function owl:Class
GO:0060374 biolink:NamedThing mast cell differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. got7fsn_ti biological_process owl:Class
GO:0016308 biolink:NamedThing 1-phosphatidylinositol-4-phosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+). got7fsn_ti PIP5K|ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity|diphosphoinositide kinase activity|PIP kinase activity|phosphatidylinositol-4-phosphate 5-kinase activity|type I PIP kinase activity|1-phosphatidylinositol-4-phosphate kinase, class IA|1-phosphatidylinositol-4-phosphate kinase activity|1-phosphatidylinositol-4-phosphate kinase, class IB|phosphatidylinositol 4-phosphate kinase activity|PtdIns(4)P-5-kinase activity GO:0045215|GO:0004431 EC:2.7.1.68|KEGG_REACTION:R03469|Reactome:R-HSA-1676082|Reactome:R-HSA-3772436|MetaCyc:2.7.1.68-RXN|RHEA:14425|Reactome:R-HSA-8868066 molecular_function owl:Class
GO:0018445 biolink:NamedThing prothoracicotrophic hormone activity The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects. got7fsn_ti molecular_function owl:Class
GO:0008865 biolink:NamedThing fructokinase activity Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate. got7fsn_ti ATP:D-fructose 6-phosphotransferase activity|D-fructokinase activity|D-fructose(D-mannose)kinase activity|fructokinase (phosphorylating) MetaCyc:FRUCTOKINASE-RXN|RHEA:16125|EC:2.7.1.4 molecular_function owl:Class
GO:0004396 biolink:NamedThing hexokinase activity Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. got7fsn_ti hexokinase D|hexokinase type III activity|glucose ATP phosphotransferase activity|ATP-dependent hexokinase activity|hexokinase type I activity|hexokinase type IV|hexokinase (phosphorylating)|hexokinase type IV glucokinase activity|ATP:D-hexose 6-phosphotransferase activity|hexokinase type II activity|hexokinase type IV (glucokinase) activity RHEA:22740|MetaCyc:HEXOKINASE-RXN|EC:2.7.1.1 molecular_function owl:Class
GO:0010788 biolink:NamedThing COPI coating of Golgi vesicle, cis-Golgi to rough ER The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat. got7fsn_ti biological_process owl:Class
GO:0048205 biolink:NamedThing COPI coating of Golgi vesicle The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat. got7fsn_ti COPI coating of Golgi-derived vesicle|COPI vesicle coating biological_process owl:Class
GO:0018686 biolink:NamedThing 6-hydroxy pseudo-oxynicotine monooxygenase activity Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine. got7fsn_ti UM-BBD_reactionID:r0480|EC:1.14.18.- molecular_function owl:Class
GO:0060891 biolink:NamedThing limb granular cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a limb epidermal granular cell. got7fsn_ti dph 2009-08-13T01:33:14Z biological_process owl:Class
GO:0072761 biolink:NamedThing cellular response to capsazepine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus. got7fsn_ti mah 2012-11-09T11:47:53Z biological_process owl:Class
GO:1901594 biolink:NamedThing response to capsazepine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus. got7fsn_ti mah 2012-11-07T17:16:53Z biological_process owl:Class
GO:0009117 biolink:NamedThing nucleotide metabolic process The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates). got7fsn_ti nucleotide metabolism biological_process owl:Class
GO:0001935 biolink:NamedThing endothelial cell proliferation The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. got7fsn_ti biological_process owl:Class
GO:0033056 biolink:NamedThing D-ornithine metabolic process The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid. got7fsn_ti D-ornithine metabolism biological_process owl:Class
GO:0021998 biolink:NamedThing neural plate mediolateral regionalization The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate. got7fsn_ti neural plate mediolateral pattern formation biological_process owl:Class
GO:0097125 biolink:NamedThing cyclin B1-CDK1 complex A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:45:15Z cellular_component owl:Class
GO:0106236 biolink:NamedThing rhamnolipid biosynthesis The chemical reactions and pathways resulting in the formation/production of a glycolipid surfactant that acts as a bacterial biofilm dispersal. got7fsn_ti rhamnolipid production hjd 2019-12-09T18:37:49Z biological_process owl:Class
GO:0009247 biolink:NamedThing glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). got7fsn_ti glycolipid anabolism|glycolipid formation|glycolipid biosynthesis|glycolipid synthesis MetaCyc:PWY-401 biological_process owl:Class
GO:0010134 biolink:NamedThing sulfate assimilation via adenylyl sulfate reduction The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase. got7fsn_ti sulphate assimilation via adenylyl sulphate reduction MetaCyc:SULFMETII-PWY biological_process owl:Class
GO:0016750 biolink:NamedThing O-succinyltransferase activity Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0097325 biolink:NamedThing melanocyte proliferation The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance. got7fsn_ti pr 2012-06-08T10:10:12Z biological_process owl:Class
GO:0052661 biolink:NamedThing S-lactaldehyde reductase activity Catalysis of the reaction: (S)-propane-1,2-diol + NAD+ = (S)-lactaldehyde + NADH + H+. got7fsn_ti L-lactaldehyde:propanediol oxidoreductase activity|(S)-propane-1,2-diol:NAD+ oxidoreductase activity KEGG_REACTION:R02258|MetaCyc:LACTALDREDUCT-RXN|RHEA:15933 molecular_function owl:Class
GO:0080097 biolink:NamedThing L-tryptophan:pyruvate aminotransferase activity Catalysis of the reaction: L-tryptophan + pyruvate = 3-(indol-3-yl)pyruvate + L-alanine. got7fsn_ti This reaction falls within the larger set of reactions associated with EC:2.6.1.28 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.28; note: 3-indole-2-oxopropanoate = indolepyruvate = 3-(indol-3-yl)pyruvate). dhl 2009-04-23T03:45:23Z MetaCyc:RXN-10139|EC:2.6.1.99|RHEA:27586 molecular_function owl:Class
GO:0009625 biolink:NamedThing response to insect Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect. got7fsn_ti response to insects GO:0043019 biological_process owl:Class
GO:0043078 biolink:NamedThing polar nucleus Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus. got7fsn_ti cellular_component owl:Class
GO:0035756 biolink:NamedThing transepithelial migration of symbiont in host The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti migration of symbiont within host by transepithelial trafficking|migration in host through an epithelial cell layer|transmigration of symbiont in host bf 2011-03-24T10:20:03Z biological_process owl:Class
GO:1900769 biolink:NamedThing fonsecin biosynthetic process The chemical reactions and pathways resulting in the formation of fonsecin. got7fsn_ti fonsecin biosynthesis|fonsecin synthesis|fonsecin anabolism|fonsecin formation di 2012-06-04T09:21:49Z biological_process owl:Class
GO:0043659 biolink:NamedThing symbiosome A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane). got7fsn_ti cellular_component owl:Class
GO:0102592 biolink:NamedThing delphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity Catalysis of the reaction: delphinidin 3-O-rutinoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> violdelphin + beta-D-glucose. got7fsn_ti MetaCyc:RXN-15354 molecular_function owl:Class
GO:0070391 biolink:NamedThing response to lipoteichoic acid Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor. got7fsn_ti response to LTA biological_process owl:Class
GO:0047375 biolink:NamedThing N-acetylgalactosaminoglycan deacetylase activity Catalysis of the reaction: H2O + N-acetyl-D-galactosaminoglycan = acetate + D-galactosaminoglycan. got7fsn_ti Vi-polysaccharide deacetylase activity|N-acetyl-D-galactosaminoglycan acetylhydrolase activity|polysaccharide deacetylase activity|N-acetyl galactosaminoglycan deacetylase activity MetaCyc:3.1.1.58-RXN|EC:3.1.1.58 molecular_function owl:Class
GO:0060025 biolink:NamedThing regulation of synaptic activity Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell. got7fsn_ti biological_process owl:Class
GO:0018630 biolink:NamedThing 3,5-xylenol methylhydroxylase activity Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol. got7fsn_ti MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN|EC:1.14.13.-|UM-BBD_reactionID:r0081 molecular_function owl:Class
GO:0001539 biolink:NamedThing cilium or flagellum-dependent cell motility Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella. got7fsn_ti ciliary/flagellar motility|ciliary or bacterial-type flagellar motility Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. biological_process owl:Class
GO:0004822 biolink:NamedThing isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+). got7fsn_ti isoleucine-tRNA synthetase activity|isoleucine translase activity|isoleucine-transfer RNA ligase activity|L-isoleucine:tRNAIle ligase (AMP-forming)|isoleucyl-transfer ribonucleate synthetase activity|isoleucyl-transfer RNA synthetase activity|isoleucyl-tRNA synthetase activity KEGG_REACTION:R03656|Reactome:R-HSA-380176|Reactome:R-HSA-379893|EC:6.1.1.5|MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN|RHEA:11060 molecular_function owl:Class
GO:0099619 biolink:NamedThing UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose. got7fsn_ti 10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase activity|UDP-L-Ara4N formyltransferase activity|ArnAFT activity EC:2.1.2.13|RHEA:24706 molecular_function owl:Class
GO:0005008 biolink:NamedThing hepatocyte growth factor-activated receptor activity Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti hepatocyte growth factor receptor activity|HGF-activated receptor activity|HGF receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand HGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class
GO:0051686 biolink:NamedThing establishment of ER localization The directed movement of the endoplasmic reticulum to a specific location. got7fsn_ti establishment of ER localisation|establishment of endoplasmic reticulum localization biological_process owl:Class
GO:0006700 biolink:NamedThing C21-steroid hormone biosynthetic process The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. got7fsn_ti C21-steroid hormone synthesis|C21-steroid hormone formation|C21-steroid hormone biosynthesis|C21-steroid hormone anabolism biological_process owl:Class
GO:0102734 biolink:NamedThing brassinolide synthase activity Catalysis of the reaction: H+ + castasterone + NADPH + O2 <=> brassinolide + NADP + H2O. got7fsn_ti MetaCyc:RXN-720 molecular_function owl:Class
GO:0036497 biolink:NamedThing eIF2alpha dephosphorylation in response to endoplasmic reticulum stress The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress. got7fsn_ti eIF2alpha dephosphorylation in response to ER stress|regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress bf 2015-02-05T10:24:18Z biological_process owl:Class
GO:0071772 biolink:NamedThing response to BMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. got7fsn_ti response to bone morphogenetic protein stimulus|response to BMP stimulus mah 2010-08-31T11:02:11Z biological_process owl:Class
GO:0018185 biolink:NamedThing poly-N-methyl-propylamination The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin. got7fsn_ti RESID:AA0278 biological_process owl:Class
GO:0018184 biolink:NamedThing protein polyamination The modification of a protein amino acid by polyamination. got7fsn_ti protein amino acid polyamination biological_process owl:Class
GO:0005484 biolink:NamedThing SNAP receptor activity Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. got7fsn_ti SNAP-25|R-SNARE activity|SNARE|Q-SNARE activity|v-SNARE activity|t-SNARE activity GO:0005486|GO:0005485 molecular_function owl:Class
GO:0018978 biolink:NamedThing anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen. got7fsn_ti anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism|anaerobic DDT metabolism|anaerobic DDT metabolic process UM-BBD_pathwayID:ddt2 biological_process owl:Class
GO:0018977 biolink:NamedThing 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide. got7fsn_ti DDT metabolic process|DDT metabolism|1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism UM-BBD_pathwayID:ddt biological_process owl:Class
GO:0018638 biolink:NamedThing toluene 4-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene. got7fsn_ti UM-BBD_enzymeID:e0225|EC:1.14.13.- molecular_function owl:Class
GO:0050300 biolink:NamedThing aminoglycoside 6-kinase activity Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 6-phosphate. got7fsn_ti streptidine kinase (phosphorylating)|streptidine kinase activity|streptomycin 6-phosphotransferase activity|streptomycin 6-O-phosphotransferase activity|SM 6-kinase activity|ATP:streptomycin 6-phosphotransferase activity|APH(6) activity|streptomycin 6-kinase activity|streptomycin 6-kinase (phosphorylating) MetaCyc:STREPTOMYCIN-6-KINASE-RXN|KEGG_REACTION:R02225|EC:2.7.1.72|RHEA:22268 molecular_function owl:Class
GO:0032303 biolink:NamedThing regulation of icosanoid secretion Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell. got7fsn_ti regulation of eicosanoid secretion biological_process owl:Class
GO:2000191 biolink:NamedThing regulation of fatty acid transport Any process that modulates the frequency, rate or extent of fatty acid transport. got7fsn_ti rl 2010-10-18T10:37:13Z biological_process owl:Class
GO:0061390 biolink:NamedThing positive regulation of direction of cell growth Any process that increases the direction of cell growth. got7fsn_ti dph 2011-07-14T10:22:55Z biological_process owl:Class
GO:0030307 biolink:NamedThing positive regulation of cell growth Any process that activates or increases the frequency, rate, extent or direction of cell growth. got7fsn_ti up regulation of cell growth|stimulation of cell growth|activation of cell growth|upregulation of cell growth|up-regulation of cell growth biological_process owl:Class
GO:0035482 biolink:NamedThing gastric motility The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum. got7fsn_ti bf 2010-04-23T10:44:59Z biological_process owl:Class
GO:0070476 biolink:NamedThing rRNA (guanine-N7)-methylation The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0019137 biolink:NamedThing thioglucosidase activity Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar. got7fsn_ti sinigrinase activity|thioglucoside glucohydrolase activity|sinigrase activity|myrosinase activity MetaCyc:RXN-9946|EC:3.2.1.147 molecular_function owl:Class
GO:0018775 biolink:NamedThing 2-hydroxymuconate-semialdehyde hydrolase activity Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate. got7fsn_ti 2-hydroxymuconate-semialdehyde formylhydrolase activity|2-hydroxymuconic semialdehyde hydrolase activity|HMSH|HOD hydrolase activity MetaCyc:3.7.1.9-RXN|RHEA:14549|EC:3.7.1.9|UM-BBD_enzymeID:e0139 molecular_function owl:Class
GO:0010054 biolink:NamedThing trichoblast differentiation The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair. got7fsn_ti trichoblast cell differentiation biological_process owl:Class
GO:0010053 biolink:NamedThing root epidermal cell differentiation The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast. got7fsn_ti biological_process owl:Class
GO:0047286 biolink:NamedThing NAD+-diphthamide ADP-ribosyltransferase activity Catalysis of the reaction: peptide diphthamide + NAD+ = peptide N-(ADP-D-ribosyl)diphthamide + niacinamide. got7fsn_ti ADP-ribosyltransferase activity|NAD-diphthamide ADP-ribosyltransferase activity|NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase activity|mono(ADP-ribosyl)transferase activity RHEA:11820|MetaCyc:RXN-11372|EC:2.4.2.36|Reactome:R-HSA-5336421 molecular_function owl:Class
GO:0008545 biolink:NamedThing JUN kinase kinase activity Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase. got7fsn_ti JNKK Reactome:R-HSA-168162 molecular_function owl:Class
GO:0004708 biolink:NamedThing MAP kinase kinase activity Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. got7fsn_ti MKK2|MEK2|MAPKK1|MAP kinase kinase 7 activity|MKK7|MKK4|MKK|MAP2K|MAPKK activity|MAPKK|MAP kinase or ERK kinase activity|ERK activator kinase activity|STK27|MKK6|MEK1|MEK activity|MAPK activator activity|mitogen-activated protein kinase kinase activity|MAP kinase kinase 4 activity|ATP:protein phosphotransferase (MAPKKK-activated) activity MetaCyc:2.7.12.2-RXN|Reactome:R-HSA-450333|EC:2.7.12.2|Reactome:R-HSA-3238999|Reactome:R-HSA-448951|Reactome:R-HSA-1247960|Reactome:R-HSA-5218804 molecular_function owl:Class
GO:0051729 biolink:NamedThing germline cell cycle switching, mitotic to meiotic cell cycle The process in which a germline cell switches cell cycle mode from mitotic to meiotic division. got7fsn_ti germline conversion to meiosis|germline initiation of meiosis|germline entry into meiosis|germline cell cycle switching, mitosis to meiosis|germline initiation of meiotic cell cycle|germline entry into meiotic cell cycle|germline conversion to meiotic cell cycle|germline meiotic entry biological_process owl:Class
GO:0052752 biolink:NamedThing reduced coenzyme F420:heterodisulfide oxidoreductase activity Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH. got7fsn_ti F420-dependent heterodisulfide oxidoreductase activity|coenzyme F420-dependent heterodisulfide oxidoreductase activity|F420H2:heterodisulfide oxidoreductase activity ai 2011-09-21T04:21:16Z molecular_function owl:Class
GO:0102932 biolink:NamedThing pterocarpan reductase activity Catalysis of the reaction: H+ + (-)-medicarpin + NADPH = (+)-vestitol + NADP. got7fsn_ti MetaCyc:RXN-8936 molecular_function owl:Class
GO:0060580 biolink:NamedThing ventral spinal cord interneuron fate determination The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron regardless of its environment; upon determination, the cell fate cannot be reversed. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. got7fsn_ti dph 2009-05-07T12:24:50Z biological_process owl:Class
GO:0097452 biolink:NamedThing GAIT complex A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. got7fsn_ti gamma interferon-activated inhibitor of translation complex|IFN-gamma-activated inhibitor of translation complex pr 2012-12-19T09:32:25Z cellular_component owl:Class
GO:0005881 biolink:NamedThing cytoplasmic microtubule Any microtubule in the cytoplasm of a cell. got7fsn_ti non-spindle-associated astral microtubule cellular_component owl:Class
GO:0042671 biolink:NamedThing retinal cone cell fate determination The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0120035 biolink:NamedThing regulation of plasma membrane bounded cell projection organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections. got7fsn_ti https://github.com/geneontology/go-ontology/issues/13298 krc 2017-04-26T16:02:06Z biological_process owl:Class
GO:0031344 biolink:NamedThing regulation of cell projection organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. got7fsn_ti regulation of cell projection organisation|regulation of cell projection organization and biogenesis biological_process owl:Class
GO:0050382 biolink:NamedThing uracil-5-carboxylate decarboxylase activity Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil. got7fsn_ti uracil-5-carboxylate carboxy-lyase activity|uracil-5-carboxylate carboxy-lyase (uracil-forming)|uracil-5-carboxylic acid decarboxylase activity KEGG_REACTION:R00973|RHEA:17685|EC:4.1.1.66|MetaCyc:URACIL-5-CARBOXYLATE-DECARBOXYLASE-RXN molecular_function owl:Class
GO:0042595 biolink:NamedThing behavioral response to starvation Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment. got7fsn_ti behavioural response to starvation biological_process owl:Class
GO:0061767 biolink:NamedThing negative regulation of lung blood pressure The process that decreases the force with which blood travels through the lungs. got7fsn_ti negative regulation of pulmonary blood pressure dph 2016-04-27T11:58:55Z biological_process owl:Class
GO:0014916 biolink:NamedThing regulation of lung blood pressure The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure. got7fsn_ti regulation of pulmonary blood pressure biological_process owl:Class
GO:0010853 biolink:NamedThing cyclase activator activity Increases the activity of an enzyme that catalyzes a ring closure reaction. got7fsn_ti molecular_function owl:Class
GO:0010851 biolink:NamedThing cyclase regulator activity Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction. got7fsn_ti molecular_function owl:Class
GO:0000488 biolink:NamedThing maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0035655 biolink:NamedThing interleukin-18-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-18-mediated signalling pathway bf 2011-01-26T09:55:57Z biological_process owl:Class
GO:0102295 biolink:NamedThing 4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity Catalysis of the reaction: 4-methylumbelliferyl glucoside + malonyl-CoA <=> 4-methylumbelliferone 6'-O-malonylglucoside + coenzyme A. got7fsn_ti MetaCyc:RXN-12699 molecular_function owl:Class
GO:0050465 biolink:NamedThing nitroquinoline-N-oxide reductase activity Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+. got7fsn_ti 4-nitroquinoline 1-oxide reductase activity|4NQO reductase activity|NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase activity|4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase activity|NAD(P)H:4-nitroquinoline-N-oxide oxidoreductase activity MetaCyc:1.7.1.9-RXN|EC:1.7.1.9 molecular_function owl:Class
GO:0003140 biolink:NamedThing determination of left/right asymmetry in lateral mesoderm The establishment of the lateral mesoderm with respect to the left and right halves. got7fsn_ti tb 2009-09-22T03:58:29Z biological_process owl:Class
GO:0003877 biolink:NamedThing ATP adenylyltransferase activity Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate. got7fsn_ti adenine triphosphate adenylyltransferase activity|diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity|AP-4-A phosphorylase activity|diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity|diadenosinetetraphosphate alphabeta-phosphorylase activity|dinucleoside oligophosphate alphabeta-phosphorylase activity|ADP:ATP adenylyltransferase activity|diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)|diadenosinetetraphosphate alpha-beta-phosphorylase activity|bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN|RHEA:16577|EC:2.7.7.53 molecular_function owl:Class
GO:0050423 biolink:NamedThing thiamine oxidase activity Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2. got7fsn_ti thiamine dehydrogenase activity|thiamin:oxygen 5-oxidoreductase activity|thiamine:oxygen 5-oxidoreductase activity|thiamin oxidase activity|thiamin dehydrogenase activity MetaCyc:THIAMIN-OXIDASE-RXN|EC:1.1.3.23|RHEA:21280 molecular_function owl:Class
GO:0097512 biolink:NamedThing cardiac myofibril A cardiac myofibril is a myofibril specific to cardiac muscle cells. got7fsn_ti pr 2013-10-16T13:04:58Z cellular_component owl:Class
GO:1990245 biolink:NamedThing histone H2A-T120 phosphorylation The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone. got7fsn_ti histone H2AT120 phosphorylation|histone H2A phosphorylation at T120 sp 2013-12-04T06:41:30Z biological_process owl:Class
GO:0021927 biolink:NamedThing deep nuclear neuron precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons. got7fsn_ti biological_process owl:Class
GO:0044196 biolink:NamedThing host cell nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic host cells. got7fsn_ti jl 2009-10-20T02:37:07Z cellular_component owl:Class
GO:0061738 biolink:NamedThing late endosomal microautophagy The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment. got7fsn_ti dph 2015-09-24T14:40:02Z biological_process owl:Class
GO:0018615 biolink:NamedThing 2-indanone monooxygenase activity Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone. got7fsn_ti UM-BBD_reactionID:r0424|EC:1.14.12.- molecular_function owl:Class
GO:0007315 biolink:NamedThing pole plasm assembly Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster. got7fsn_ti GO:0048113 biological_process owl:Class
GO:0070739 biolink:NamedThing protein-glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein. got7fsn_ti protein-glutamate ligase activity|protein glutamylase activity mah 2009-06-19T02:23:22Z molecular_function owl:Class
GO:0018057 biolink:NamedThing peptidyl-lysine oxidation The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens. got7fsn_ti RESID:AA0121 biological_process owl:Class
GO:0019589 biolink:NamedThing anaerobic glycerol catabolic process to propane-1,3-diol The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water. got7fsn_ti glycerol fermentation to 1,3-propanediol|glycerol fermentation to propane-1,3-diol MetaCyc:GOLPDLCAT-PWY biological_process owl:Class
GO:0019588 biolink:NamedThing anaerobic glycerol catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP. got7fsn_ti glycerol fermentation biological_process owl:Class
GO:0031102 biolink:NamedThing neuron projection regeneration The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. got7fsn_ti neurite regeneration biological_process owl:Class
GO:0033691 biolink:NamedThing sialic acid binding Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria. got7fsn_ti N-acetylneuraminic acid binding molecular_function owl:Class
GO:0102625 biolink:NamedThing cirsimaritin 4'-O-methyltransferase activity Catalysis of the reaction: cirsimaritin + S-adenosyl-L-methionine <=> salvigenin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-15530 molecular_function owl:Class
GO:0031100 biolink:NamedThing animal organ regeneration The regrowth of a lost or destroyed animal organ. got7fsn_ti biological_process owl:Class
GO:0045748 biolink:NamedThing positive regulation of R8 cell spacing in compound eye Any process that activates or enforces the correct R8 cell spacing in a compound eye. got7fsn_ti upregulation of R8 spacing|up regulation of R8 spacing|up-regulation of R8 spacing|stimulation of R8 spacing|positive regulation of R8 spacing|activation of R8 spacing biological_process owl:Class
GO:0070168 biolink:NamedThing negative regulation of biomineral tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. got7fsn_ti biological_process owl:Class
GO:0080067 biolink:NamedThing 4-methylthiobutyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 4-methylthiobutyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 4-methylthiobutyl-glucosinolate + adenosine 3',5'-bisphosphate. got7fsn_ti dhl 2009-04-13T04:05:53Z MetaCyc:RXNQT-4329 molecular_function owl:Class
GO:0102636 biolink:NamedThing 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine gamma-glutamylcyclotransferase activity Catalysis of the reaction: 3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine <=> 3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine + 2 5-oxo-L-prolinate. got7fsn_ti MetaCyc:RXN-15681 molecular_function owl:Class
GO:0098685 biolink:NamedThing Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. got7fsn_ti dos 2017-02-05T16:29:43Z cellular_component owl:Class
GO:0090429 biolink:NamedThing detection of endogenous biotic stimulus The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal. got7fsn_ti tb 2012-05-11T09:19:39Z biological_process owl:Class
GO:0000297 biolink:NamedThing spermine transmembrane transporter activity Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. got7fsn_ti molecular_function owl:Class
GO:0015203 biolink:NamedThing polyamine transmembrane transporter activity Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other. got7fsn_ti amine/amide/polyamine channel activity molecular_function owl:Class
GO:0060076 biolink:NamedThing excitatory synapse A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. got7fsn_ti Wikipedia:Excitatory_synapse cellular_component owl:Class
GO:1904072 biolink:NamedThing presynaptic active zone disassembly The disaggregation of a presynaptic active zone into its constituent components. got7fsn_ti pre-synaptic active zone component disassembly|pre-synaptic active zone disassembly pr 2015-03-20T10:36:33Z biological_process owl:Class
GO:0050217 biolink:NamedThing propioin synthase activity Catalysis of the reaction: 4-hydroxyhexan-3-one = 2 propanal. got7fsn_ti 4-hydroxy-3-hexanone propanal-lyase (propanal-forming)|4-hydroxy-3-hexanone aldolase activity|4-hydroxy-3-hexanone propanal-lyase activity EC:4.1.2.35|RHEA:11100|KEGG_REACTION:R00038|MetaCyc:PROPIOIN-SYNTHASE-RXN molecular_function owl:Class
GO:0070009 biolink:NamedThing serine-type aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 molecular_function owl:Class
GO:0070008 biolink:NamedThing serine-type exopeptidase activity Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). got7fsn_ti EC:3.4.21.- molecular_function owl:Class
GO:0034146 biolink:NamedThing toll-like receptor 5 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 5. got7fsn_ti toll-like receptor 5 signalling pathway|TLR5 signaling pathway biological_process owl:Class
GO:0044171 biolink:NamedThing host cell smooth endoplasmic reticulum membrane The lipid bilayer surrounding the host cell smooth endoplasmic reticulum. got7fsn_ti host smooth endoplasmic reticulum membrane jl 2009-09-04T11:46:00Z cellular_component owl:Class
GO:0009303 biolink:NamedThing rRNA transcription The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template. got7fsn_ti rRNA biosynthetic process|rRNA synthesis|rRNA biosynthesis biological_process owl:Class
GO:0043974 biolink:NamedThing histone H3-K27 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone. got7fsn_ti histone H3K27 acetylation|histone H3 acetylation at K27 biological_process owl:Class
GO:0060474 biolink:NamedThing positive regulation of flagellated sperm motility involved in capacitation The process in which the controlled movement of a flagellated sperm cell is initiated as part of the process required for flagellated sperm to reach fertilization competence. got7fsn_ti positive regulation of sperm motility involved in capacitation biological_process owl:Class
GO:0009040 biolink:NamedThing ureidoglycolate dehydrogenase activity Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+. got7fsn_ti (S)-ureidoglycolate:NAD(P)+ oxidoreductase activity MetaCyc:R165-RXN|EC:1.1.1.154 molecular_function owl:Class
GO:0080075 biolink:NamedThing spermidine:feruloyl CoA N-acyltransferase activity Catalysis of the transfer of a feruloyl group to a nitrogen atom on the spermidine molecule. got7fsn_ti dhl 2009-04-13T04:17:50Z molecular_function owl:Class
GO:0140367 biolink:NamedThing antibacterial innate immune response An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens. got7fsn_ti pg 2019-09-09T11:02:47Z biological_process owl:Class
GO:0097061 biolink:NamedThing dendritic spine organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. got7fsn_ti dendritic spine organisation pr 2011-06-07T11:26:53Z biological_process owl:Class
GO:0003837 biolink:NamedThing beta-ureidopropionase activity Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3. got7fsn_ti N-carbamoyl-beta-alanine amidohydrolase activity RHEA:11184|Reactome:R-HSA-73591|EC:3.5.1.6|Reactome:R-HSA-73620|MetaCyc:BETA-UREIDOPROPIONASE-RXN molecular_function owl:Class
GO:0048785 biolink:NamedThing hatching gland development The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process. got7fsn_ti biological_process owl:Class
GO:0150001 biolink:NamedThing primary dendrite A dendrite emerging from the cell body (the soma) of a neuron. got7fsn_ti cellular_component owl:Class
GO:0048311 biolink:NamedThing mitochondrion distribution Any process that establishes the spatial arrangement of mitochondria between and within cells. got7fsn_ti positioning of mitochondria|distribution of mitochondria|mitochondrial distribution biological_process owl:Class
GO:0051646 biolink:NamedThing mitochondrion localization Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell. got7fsn_ti localization of mitochondrion|localization of mitochondria|mitochondrial localization|establishment and maintenance of mitochondria localization|establishment and maintenance of mitochondrion localization|mitochondria localization|mitochondrion localisation biological_process owl:Class
GO:0045322 biolink:NamedThing unmethylated CpG binding Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters. got7fsn_ti molecular_function owl:Class
GO:0033361 biolink:NamedThing lysine biosynthetic process via diaminopimelate, dehydrogenase pathway The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in a single enzymatic step. got7fsn_ti lysine biosynthesis via diaminopimelic acid, dehydrogenase pathway|lysine anabolism via diaminopimelate, dehydrogenase pathway|lysine synthesis via diaminopimelate, dehydrogenase pathway|lysine formation via diaminopimelate, dehydrogenase pathway MetaCyc:PWY-2942 biological_process owl:Class
GO:0009089 biolink:NamedThing lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. got7fsn_ti lysine biosynthetic process via diaminopimelic acid|lysine synthesis via diaminopimelate|diaminopimelic acid pathway|diaminopimelate pathway|lysine formation via diaminopimelate|lysine biosynthesis via diaminopimelic acid|lysine anabolism via diaminopimelate biological_process owl:Class
GO:0007175 biolink:NamedThing negative regulation of epidermal growth factor-activated receptor activity Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity. got7fsn_ti negative regulation of epidermal growth factor receptor activity|EGF receptor downregulation|inhibition of epidermal growth factor receptor activity|down-regulation of epidermal growth factor receptor activity|negative regulation of EGF receptor activity|down regulation of epidermal growth factor receptor activity|downregulation of epidermal growth factor receptor activity|negative regulation of EGFR activity GO:0007177 biological_process owl:Class
GO:0018507 biolink:NamedThing cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol. got7fsn_ti cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity|(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity EC:1.3.1.49|MetaCyc:1.3.1.49-RXN|KEGG_REACTION:R04151|RHEA:16253|UM-BBD_reactionID:r0488 molecular_function owl:Class
GO:0034453 biolink:NamedThing microtubule anchoring Any process in which a microtubule is maintained in a specific location in a cell. got7fsn_ti biological_process owl:Class
GO:0047416 biolink:NamedThing arylalkyl acylamidase activity Catalysis of the reaction: H2O + N-acetylarylalkylamine = acetate + arylalkylamine. got7fsn_ti aralkyl acylamidase activity|N-acetylarylalkylamine amidohydrolase activity EC:3.5.1.76|RHEA:10352|MetaCyc:3.5.1.76-RXN molecular_function owl:Class
GO:0048478 biolink:NamedThing replication fork protection Any process that prevents the collapse of stalled replication forks. got7fsn_ti replication fork maintenance|replication fork stabilization biological_process owl:Class
GO:2000104 biolink:NamedThing negative regulation of DNA-dependent DNA replication Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication. got7fsn_ti mah 2010-09-15T01:37:05Z biological_process owl:Class
GO:0017101 biolink:NamedThing aminoacyl-tRNA synthetase multienzyme complex A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates. got7fsn_ti aminoacyl-tRNA synthetase complex|multisynthetase complex cellular_component owl:Class
GO:0071852 biolink:NamedThing fungal-type cell wall organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall. got7fsn_ti fungal-type cell wall organization and biogenesis|fungal-type cell wall organisation or biogenesis mah 2010-09-10T03:07:55Z biological_process owl:Class
GO:0097044 biolink:NamedThing histone H3-K56 acetylation in response to DNA damage The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell. got7fsn_ti pr 2011-04-19T05:22:54Z biological_process owl:Class
GO:0031759 biolink:NamedThing Edg-6 sphingosine 1-phosphate receptor binding Binding to an Edg-6 sphingosine 1-phosphate receptor. got7fsn_ti Edg-6 sphingosine 1-phosphate receptor ligand molecular_function owl:Class
GO:0016414 biolink:NamedThing O-octanoyltransferase activity Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0008281 biolink:NamedThing sulfonylurea receptor activity Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti sulphonylurea receptor activity Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'. molecular_function owl:Class
GO:0052368 biolink:NamedThing disruption by organism of cellular component in other organism involved in symbiotic interaction The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti catabolism of cellular component in other organism|disassembly by organism of cellular component in other organism during symbiotic interaction|catabolism of structural constituent in other organism|degradation of cellular component in other organism|disassembly by organism of cellular component in other organism involved in symbiotic interaction biological_process owl:Class
GO:0044552 biolink:NamedThing vasodilation in other organism A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism. got7fsn_ti regulation of vasodilation in other organism|modulation of vasodilation in other organism jl 2012-03-29T02:14:42Z biological_process owl:Class
GO:0034894 biolink:NamedThing 4-hydroxypyridine-3-hydroxylase activity Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+. got7fsn_ti UM-BBD_reactionID:r1397|EC:1.14.13.- molecular_function owl:Class
GO:0080018 biolink:NamedThing anthocyanin 5-O-glucosyltransferase activity Catalysis of the reaction: an anthocyanin + UDP-D-glucose = an anthocyanin-5-O-glucoside + UDP. got7fsn_ti molecular_function owl:Class
GO:0098831 biolink:NamedThing presynaptic active zone cytoplasmic component A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles. got7fsn_ti presynaptic zone cortex|cortex of presynaptic active zone cellular_component owl:Class
GO:0045948 biolink:NamedThing positive regulation of translational initiation Any process that activates or increases the frequency, rate or extent of translational initiation. got7fsn_ti stimulation of translational initiation|up-regulation of translational initiation|activation of translational initiation|up regulation of translational initiation|upregulation of translational initiation biological_process owl:Class
GO:0034878 biolink:NamedThing 2-hydroxyisonicotinate dehydrogenase activity Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor. got7fsn_ti UM-BBD_reactionID:r1338 molecular_function owl:Class
GO:0046741 biolink:NamedThing transport of virus in host, tissue to tissue The transport of a virus between tissues in a multicellular organism. got7fsn_ti spread of virus within host, tissue to tissue|spread of virus in host, tissue to tissue|viral spread within host, tissue to tissue|tissue to tissue spread of virus within host biological_process owl:Class
GO:2001231 biolink:NamedThing regulation of protein localization to prospore membrane Any process that modulates the frequency, rate or extent of protein localization to prospore membrane. got7fsn_ti regulation of protein targeting to forespore membrane|regulation of protein localisation to prospore membrane|regulation of protein targeting to FSM|regulation of protein targeting to prospore membrane|regulation of protein targeting to ascospore-type prospore membrane|regulation of protein-prospore membrane targeting mah 2011-11-21T04:13:30Z biological_process owl:Class
GO:1903076 biolink:NamedThing regulation of protein localization to plasma membrane Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. got7fsn_ti regulation of protein targeting to plasma membrane|regulation of establishment of protein localisation in plasma membrane|regulation of establishment of protein localization in plasma membrane|regulation of protein localization in plasma membrane|regulation of protein-plasma membrane targeting|regulation of establishment of protein localization to plasma membrane|regulation of protein localisation in plasma membrane tb 2009-07-10T10:32:44Z GO:0090003|GO:1905963 biological_process owl:Class
GO:1990526 biolink:NamedThing Ste12p-Dig1p-Dig2p complex A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae. got7fsn_ti rb 2014-11-05T22:49:32Z cellular_component owl:Class
GO:0072503 biolink:NamedThing cellular divalent inorganic cation homeostasis Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell. got7fsn_ti Note that this term was split from 'cellular di-, tri-valent inorganic cation homeostasis ; GO:0030005' (sibling term 'cellular trivalent inorganic cation homeostasis' ; GO:0072504'). mah 2010-12-16T01:25:40Z biological_process owl:Class
GO:0099507 biolink:NamedThing ligand-gated ion channel activity involved in regulation of presynaptic membrane potential Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. got7fsn_ti ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential|ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential|ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential|ligand gated ion channel activity involved in regulation of presynaptic membrane potential molecular_function owl:Class
GO:0015476 biolink:NamedThing hemaglutinin autotransporter activity Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively. got7fsn_ti molecular_function owl:Class
GO:0019062 biolink:NamedThing virion attachment to host cell The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection. got7fsn_ti virion attachment to host cell surface receptor|viral attachment to host cell|viral absorption VZ:956 biological_process owl:Class
GO:0018810 biolink:NamedThing trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene. got7fsn_ti UM-BBD_reactionID:r0164 molecular_function owl:Class
GO:0098582 biolink:NamedThing innate vocalization behavior A vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur. got7fsn_ti dos 2014-01-24T12:47:01Z biological_process owl:Class
GO:0052729 biolink:NamedThing dimethylglycine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N,N-dimethylglycine = S-adenosyl-L-homocysteine + betaine. got7fsn_ti ApDMT|S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase activity ai 2011-08-16T03:45:16Z EC:2.1.1.162|MetaCyc:R482-RXN|MetaCyc:RXN-9680|EC:2.1.1.161|KEGG_REACTION:R07244|RHEA:10072|EC:2.1.1.157 molecular_function owl:Class
GO:0051986 biolink:NamedThing negative regulation of attachment of spindle microtubules to kinetochore Any process that stops, prevents, or reduces the frequency, rate or extent of the attachment of spindle microtubules to the kinetochore. got7fsn_ti inhibition of attachment of spindle microtubules to kinetochore|downregulation of attachment of spindle microtubules to kinetochore|down-regulation of attachment of spindle microtubules to kinetochore|down regulation of attachment of spindle microtubules to kinetochore biological_process owl:Class
GO:0051985 biolink:NamedThing negative regulation of chromosome segregation Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. got7fsn_ti inhibition of chromosome segregation|down-regulation of chromosome segregation|down regulation of chromosome segregation|downregulation of chromosome segregation biological_process owl:Class
GO:0006618 biolink:NamedThing SRP-dependent cotranslational protein targeting to membrane, signal sequence processing The removal of the signal peptide from a nascent protein during cotranslational membrane targeting. got7fsn_ti SRP-dependent cotranslational protein-membrane targeting, signal sequence processing|signal sequence processing during SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational membrane targeting, signal sequence processing biological_process owl:Class
GO:0008482 biolink:NamedThing sulfite oxidase activity Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate. got7fsn_ti sulfite:oxygen oxidoreductase activity|sulphite oxidase activity MetaCyc:SULFITE-OXIDASE-RXN|EC:1.8.3.1|RHEA:24600|Reactome:R-HSA-1614544|MetaCyc:PWY-5326|KEGG_REACTION:R00533 molecular_function owl:Class
GO:1902178 biolink:NamedThing fibroblast growth factor receptor apoptotic signaling pathway An apoptotic signaling pathway that starts with a ligand binding to, or being withdrawn from, a fibroblast growth factor receptor (FGFR). got7fsn_ti fibroblast growth factor receptor signaling pathway involved in apoptotic process|fibroblast growth factor receptor signaling pathway involved in apoptotic programmed cell death|FGF receptor signalling pathway involved in apoptotic cell death|FGF receptor signaling pathway involved in apoptotic process|FGFR signaling pathway involved in apoptotic program|fibroblast growth factor receptor signalling pathway involved in apoptotic programmed cell death|FGF receptor signaling pathway involved in type I programmed cell death|FGFR signaling pathway involved in programmed cell death by apoptosis|FGFR signaling pathway involved in signaling (initiator) caspase activity|fibroblast growth factor receptor signalling pathway involved in apoptosis|FGF receptor signalling pathway involved in apoptotic program|FGFR signaling pathway involved in apoptotic cell death|FGFR signaling pathway involved in apoptosis|FGF receptor signaling pathway involved in signaling (initiator) caspase activity|fibroblast growth factor receptor signalling pathway involved in signaling (initiator) caspase activity|FGFR signaling pathway involved in apoptotic process|FGF receptor signaling pathway involved in programmed cell death by apoptosis|FGF receptor signalling pathway involved in programmed cell death by apoptosis|FGF receptor signalling pathway involved in apoptotic programmed cell death|fibroblast growth factor receptor signaling pathway involved in apoptotic program|FGFR signaling pathway involved in apoptotic programmed cell death|fibroblast growth factor receptor signaling pathway involved in signaling (initiator) caspase activity|fibroblast growth factor receptor signaling pathway involved in type I programmed cell death|fibroblast growth factor receptor signalling pathway involved in programmed cell death by apoptosis|fibroblast growth factor receptor signalling pathway involved in type I programmed cell death|FGF receptor signaling pathway involved in apoptotic program|FGFR signaling pathway involved in type I programmed cell death|FGF receptor signaling pathway involved in apoptotic cell death|fibroblast growth factor receptor signalling pathway involved in apoptotic cell death|FGF receptor signaling pathway involved in apoptosis|FGF receptor signalling pathway involved in apoptotic process|fibroblast growth factor receptor signaling pathway involved in programmed cell death by apoptosis|fibroblast growth factor receptor signaling pathway involved in apoptotic cell death|FGF receptor signalling pathway involved in type I programmed cell death|fibroblast growth factor receptor signaling pathway involved in apoptosis|fibroblast growth factor receptor signalling pathway involved in apoptotic process|FGF receptor signaling pathway involved in apoptotic programmed cell death|FGF receptor signalling pathway involved in signaling (initiator) caspase activity|FGF receptor signalling pathway involved in apoptosis|fibroblast growth factor receptor signalling pathway involved in apoptotic program pm 2013-05-30T13:59:57Z biological_process owl:Class
GO:0102845 biolink:NamedThing 1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:3-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8307 molecular_function owl:Class
GO:0097356 biolink:NamedThing perinucleolar compartment The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC. got7fsn_ti perinucleolar region pr 2012-07-03T05:11:01Z cellular_component owl:Class
GO:0140222 biolink:NamedThing pathogen-containing vacuole lumen The enclosed volume within the sealed membrane of a pathogen-containing vacuole. got7fsn_ti lumen of a pathogen-containing vacuole|pathogen-containing vacuolar lumen|pathogen-containing compartment lumen|pathogen inclusion lumen https://github.com/geneontology/go-ontology/issues/15580 pg 2018-04-20T06:24:02Z cellular_component owl:Class
GO:0060176 biolink:NamedThing regulation of aggregation involved in sorocarp development Any process that modulates the frequency, rate or extent of aggregation during sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. got7fsn_ti biological_process owl:Class
GO:0019099 biolink:NamedThing female germ-line sex determination The determination of sex and sexual phenotype in a female organism's germ line. got7fsn_ti sex determination, female germ-line determination GO:0007544 biological_process owl:Class
GO:0007542 biolink:NamedThing primary sex determination, germ-line The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line. got7fsn_ti biological_process owl:Class
GO:0034385 biolink:NamedThing triglyceride-rich plasma lipoprotein particle A plasma lipoprotein particle that has a hydrophobic core enriched in triglycerides surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Triglyceride-rich lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood. got7fsn_ti triglyceride-rich lipoprotein particle|triacylglycerol-rich lipoprotein particle cellular_component owl:Class
GO:0099513 biolink:NamedThing polymeric cytoskeletal fiber A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. got7fsn_ti cellular_component owl:Class
GO:0001855 biolink:NamedThing complement component C4b binding Binding to a C4b product of the classical complement cascade. got7fsn_ti molecular_function owl:Class
GO:0072281 biolink:NamedThing mesenchymal stem cell differentiation involved in metanephric nephron morphogenesis The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti mah 2010-04-01T03:22:06Z biological_process owl:Class
GO:0004135 biolink:NamedThing amylo-alpha-1,6-glucosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present. got7fsn_ti dextrin 6-alpha-D-glucosidase activity|glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity|amylo-1,6-glucosidase activity|dextrin-1,6-glucosidase activity|amylopectin 1,6-glucosidase activity EC:3.2.1.33|Reactome:R-HSA-71593|MetaCyc:3.2.1.33-RXN molecular_function owl:Class
GO:1990799 biolink:NamedThing mitochondrial tRNA wobble position uridine thiolation The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. got7fsn_ti vw 2015-07-13T08:15:15Z biological_process owl:Class
GO:0034075 biolink:NamedThing arabidiol synthase activity Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol). got7fsn_ti EC:4.2.1.124|RHEA:31035|MetaCyc:RXN-9684 molecular_function owl:Class
GO:0036424 biolink:NamedThing L-phosphoserine phosphatase activity Catalysis of the reaction: O-phospho-L-serine + H2O = L-serine + phosphate, on a free amino acid. got7fsn_ti phosphoserine phosphatase activity|O-phosphoserine phosphohydrolase activity https://github.com/geneontology/go-ontology/issues/21638|https://github.com/geneontology/go-ontology/issues/20587 Do not confuse with protein phosphatases. For protein phosphatases, consider GO:0004722 ; protein serine/threonine phosphatase activity or GO:0008138 ; protein tyrosine/serine/threonine phosphatase activity. bf 2013-09-16T13:01:03Z GO:0004647 EC:3.1.3.3|MetaCyc:PSERPHOSPHA-RXN|MetaCyc:RXN0-5114|RHEA:21208|Reactome:R-HSA-977324|KEGG_REACTION:R00582 molecular_function owl:Class
GO:0051272 biolink:NamedThing positive regulation of cellular component movement Any process that activates or increases the frequency, rate or extent of the movement of a cellular component. got7fsn_ti positive regulation of cellular component motion biological_process owl:Class
GO:0071424 biolink:NamedThing rRNA (cytosine-N4-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N4-methylcytosine. got7fsn_ti mah 2009-12-15T03:46:52Z molecular_function owl:Class
GO:0032182 biolink:NamedThing ubiquitin-like protein binding Binding to a small conjugating protein such as ubiquitin or a ubiquitin-like protein. got7fsn_ti small conjugating protein binding molecular_function owl:Class
GO:0102552 biolink:NamedThing lipoyl synthase activity (acting on glycine-cleavage complex H protein Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [glycine-cleavage complex H protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + a [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. got7fsn_ti EC:2.8.1.8|MetaCyc:RXN-14950 molecular_function owl:Class
GO:0015074 biolink:NamedThing DNA integration The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. got7fsn_ti biological_process owl:Class
GO:0004587 biolink:NamedThing ornithine-oxo-acid transaminase activity Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid. got7fsn_ti ornithine--alpha-ketoglutarate aminotransferase activity|ornithine transaminase activity|ornithine-oxo-acid aminotransferase activity|ornithine--oxo acid aminotransferase activity|GabT|L-ornithine:2-oxo-acid aminotransferase activity|ornithine--keto acid aminotransferase activity|ornithine--ketoglutarate aminotransferase activity|ornithine ketoacid aminotransferase activity|ornithine delta-transaminase activity|OAT|ornithine 5-aminotransferase activity|ornithine--oxo-acid transaminase activity|L-ornithine:alpha-ketoglutarate delta-aminotransferase activity|ornithine:alpha-oxoglutarate transaminase activity|ornithine--keto acid transaminase activity|ornithine aminotransferase activity|L-ornithine aminotransferase activity|L-ornithine 5-aminotransferase activity|ornithine--2-oxoacid aminotransferase activity EC:2.6.1.13|Reactome:R-HSA-70654|RHEA:13877|Reactome:R-HSA-70666|MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:2000693 biolink:NamedThing positive regulation of seed maturation Any process that activates or increases the frequency, rate or extent of seed maturation. got7fsn_ti dhl 2011-05-13T06:41:46Z biological_process owl:Class
GO:0022831 biolink:NamedThing narrow pore, gated channel activity Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus. got7fsn_ti ion channels Wikipedia:Ion_channels molecular_function owl:Class
GO:0022842 biolink:NamedThing narrow pore channel activity Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. got7fsn_ti molecular_function owl:Class
GO:0098597 biolink:NamedThing observational learning Learning that occurs through observing the behavior of others. got7fsn_ti Observation here is used in a broad sense to include perception of the behavior of others via any form or combination of forms of sensory perception (visual, auditory etc). Observational learning is broader than imitative learning in that it does not require a duplication of the behavior exhibited by the model. dos 2014-04-10T11:07:10Z Wikipedia:Observational_learning biological_process owl:Class
GO:0050196 biolink:NamedThing [phosphorylase] phosphatase activity Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate. got7fsn_ti PR-enzyme|phosphorylase a phosphohydrolase activity|type 1 protein phosphatase activity|phosphorylase a phosphatase activity|glycogen phosphorylase phosphatase activity|phosphorylase phosphatase activity|protein phosphatase C EC:3.1.3.17|MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN molecular_function owl:Class
GO:1900125 biolink:NamedThing regulation of hyaluronan biosynthetic process Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process. got7fsn_ti regulation of hyaluronan biosynthesis|regulation of hyaluronan synthesis|regulation of hyaluronan anabolism|regulation of hyaluronan formation yaf 2012-02-23T01:09:21Z biological_process owl:Class
GO:0042309 biolink:NamedThing homoiothermy Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. got7fsn_ti ice nucleation activity|antifreeze activity|ice nucleation inhibitor activity biological_process owl:Class
GO:0003831 biolink:NamedThing beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide. got7fsn_ti glycoprotein 4-beta-galactosyl-transferase activity|GalT activity|thyroid glycoprotein beta-galactosyltransferase|uridine diphosphogalactose-glycoprotein galactosyltransferase activity|UDP-galactose--glycoprotein galactosyltransferase activity|thyroid galactosyltransferase activity|glycoprotein beta-galactosyltransferase activity|beta-N-acetyl-beta-(1,4)-galactosyltransferase activity|glycoprotein 4-beta-galactosyltransferase activity|beta-N-acetyl-beta-1,4-galactosyltransferase activity|UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity|UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity|UDPgalactose-glycoprotein galactosyltransferase activity Reactome:R-HSA-975919|Reactome:R-HSA-2046298|Reactome:R-HSA-1912352|Reactome:R-HSA-4793956|Reactome:R-HSA-2046265|Reactome:R-HSA-9035949|RHEA:22932|Reactome:R-HSA-2025723|MetaCyc:2.4.1.38-RXN|EC:2.4.1.38|Reactome:R-HSA-3656230|Reactome:R-HSA-9035950 molecular_function owl:Class
GO:0030562 biolink:NamedThing rRNA 2'-O-ribose methylation guide activity Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0030556 biolink:NamedThing rRNA modification guide activity Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0102406 biolink:NamedThing omega-hydroxypalmitate O-sinapoyl transferase activity Catalysis of the reaction: sinapoyl-CoA + 16-hydroxypalmitate <=> coenzyme A + 16-sinapoyloxypalmitate. got7fsn_ti RHEA:26470|EC:2.3.1.188|MetaCyc:RXN-13728 molecular_function owl:Class
GO:0034154 biolink:NamedThing toll-like receptor 7 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 7. got7fsn_ti toll-like receptor 7 signalling pathway|TLR7 signaling pathway biological_process owl:Class
GO:0072260 biolink:NamedThing metanephric interstitial fibroblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric interstitial fibroblast. got7fsn_ti metanephros interstitial cell fate commitment mah 2010-03-19T04:18:10Z biological_process owl:Class
GO:0072153 biolink:NamedThing renal interstitial fibroblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast. got7fsn_ti kidney interstitial cell fate commitment mah 2010-02-24T02:16:53Z biological_process owl:Class
GO:0030538 biolink:NamedThing embryonic genitalia morphogenesis The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized. got7fsn_ti embryonic genital morphogenesis biological_process owl:Class
GO:0070559 biolink:NamedThing lysosomal multienzyme complex A protein complex found in the lysosome that contains beta-galactosidase, cathepsin A, alpha-neuraminidase and N-acetylgalactosamine-6-sulfate sulfatase, and is involved in glycosaminoglycan catabolism. got7fsn_ti GALNS-lysosomal hydrolase 1.27 MDa complex cellular_component owl:Class
GO:0030309 biolink:NamedThing poly-N-acetyllactosamine metabolic process The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. got7fsn_ti poly-N-acetyllactosamine metabolism biological_process owl:Class
GO:0050872 biolink:NamedThing white fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole. got7fsn_ti white adipocyte cell differentiation|white adipocyte differentiation biological_process owl:Class
GO:0045444 biolink:NamedThing fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. got7fsn_ti adipocyte cell differentiation|adipocyte differentiation|adipogenesis|adipose cell differentiation biological_process owl:Class
GO:0018413 biolink:NamedThing peptidyl-serine O-glucuronidation The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine. got7fsn_ti RESID:AA0291 biological_process owl:Class
GO:0018412 biolink:NamedThing protein O-glucuronidation The modification of a protein by glucuronidation on an amino acid oxygen atom. got7fsn_ti protein amino acid O-glucuronidation biological_process owl:Class
GO:0015851 biolink:NamedThing nucleobase transport The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti nucleobase transmembrane transport biological_process owl:Class
GO:0018572 biolink:NamedThing 3,5-dichlorocatechol 1,2-dioxygenase activity Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0276 molecular_function owl:Class
GO:0051776 biolink:NamedThing detection of redox state The series of events in which a chemical stimulus indicating redox state is received and converted into a molecular signal. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. got7fsn_ti redox sensing biological_process owl:Class
GO:0102245 biolink:NamedThing lupan-3beta,20-diol synthase activity Catalysis of the reaction: lupan-3beta,20-diol <=> (S)-2,3-epoxysqualene + H2O. got7fsn_ti EC:4.2.1.128|RHEA:31351|MetaCyc:RXN-12338 molecular_function owl:Class
GO:0020015 biolink:NamedThing glycosome A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis. got7fsn_ti Wikipedia:Glycosome cellular_component owl:Class
GO:0098037 biolink:NamedThing viral DNA genome packaging, 5' extended cos packaging The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 5' protruding ends. got7fsn_ti bm 2012-07-20T11:40:47Z biological_process owl:Class
GO:0031638 biolink:NamedThing zymogen activation The proteolytic processing of an inactive enzyme to an active form. got7fsn_ti zymogen activation by proteolytic cleavage biological_process owl:Class
GO:0060107 biolink:NamedThing annuli extracellular matrix The extracellular matrix that is a regularly spaced circumferential ridge present in the cortical region of the cuticle. Annuli are delineated by annular furrows and are present throughout the cuticle with the exception of lateral regions where longitudinal alae are present. got7fsn_ti annulus|annulae|annule(s)|annular rings cellular_component owl:Class
GO:0061504 biolink:NamedThing cyclic threonylcarbamoyladenosine biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules. got7fsn_ti dph 2013-01-22T14:25:00Z biological_process owl:Class
GO:0046554 biolink:NamedThing malate dehydrogenase (NADP+) activity Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. got7fsn_ti NADP-malate dehydrogenase activity|malic dehydrogenase (nicotinamide adenine dinucleotide phosphate)|(S)-malate:NADP+ oxidoreductase activity|NADP malate dehydrogenase activity|NADP-linked malate dehydrogenase activity|malate NADP dehydrogenase activity RHEA:10824|KEGG_REACTION:R00343|EC:1.1.1.82|MetaCyc:MALATE-DEHYDROGENASE-NADP+-RXN molecular_function owl:Class
GO:0046844 biolink:NamedThing chorion micropyle formation Establishment of the micropyle, a single cone-shaped specialization of the chorion that allows sperm entry into the egg prior to fertilization. got7fsn_ti biological_process owl:Class
GO:0062183 biolink:NamedThing all-trans retinoic acid 18-hydroxylase activity Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-18-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti dph 2019-11-26T18:41:32Z RHEA:55856 molecular_function owl:Class
GO:1990896 biolink:NamedThing protein localization to cell cortex of cell tip A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip. got7fsn_ti vw 2015-11-05T08:41:49Z biological_process owl:Class
GO:0033619 biolink:NamedThing membrane protein proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. got7fsn_ti biological_process owl:Class
GO:0033334 biolink:NamedThing fin morphogenesis The process in which the anatomical structures of a fin are generated and organized. got7fsn_ti biological_process owl:Class
GO:0003934 biolink:NamedThing GTP cyclohydrolase I activity Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate. got7fsn_ti guanosine triphosphate 8-deformylase activity|dihydroneopterin triphosphate synthase activity|GTP 8-formylhydrolase activity|guanosine triphosphate cyclohydrolase activity|GTP 7,8-8,9-dihydrolase activity EC:3.5.4.16|MetaCyc:GTP-CYCLOHYDRO-I-RXN|Reactome:R-HSA-1474146|RHEA:17473|KEGG_REACTION:R00424 molecular_function owl:Class
GO:0045238 biolink:NamedThing CXCR2 chemokine receptor binding Binding to a CXCR2 chemokine receptor. got7fsn_ti CXCR2 chemokine receptor ligand molecular_function owl:Class
GO:0005153 biolink:NamedThing interleukin-8 receptor binding Binding to an interleukin-8 receptor. got7fsn_ti IL-8|interleukin-8 receptor ligand molecular_function owl:Class
GO:0061045 biolink:NamedThing negative regulation of wound healing Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. got7fsn_ti dph 2010-02-25T10:33:30Z biological_process owl:Class
GO:0047733 biolink:NamedThing CDP-glucose 4,6-dehydratase activity Catalysis of the reaction: CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H(2)O. got7fsn_ti cytidine diphosphoglucose oxidoreductase activity|CDPglucose 4,6-hydro-lyase activity|CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming)|CDPglucose 4,6-dehydratase activity|CDP-glucose 4,6-hydro-lyase activity EC:4.2.1.45|MetaCyc:CDP-GLUCOSE-46-DEHYDRATASE-RXN|RHEA:17153|KEGG_REACTION:R02426 molecular_function owl:Class
GO:0046859 biolink:NamedThing hydrogenosomal membrane The lipid bilayer surrounding a hydrogenosome. got7fsn_ti hydrogenosome membrane cellular_component owl:Class
GO:1990166 biolink:NamedThing protein localization to site of double-strand break Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred. got7fsn_ti protein localization to site of DSB|protein localisation to site of double-strand break|protein localization to double-strand break site mah 2013-08-08T11:27:00Z biological_process owl:Class
GO:0047974 biolink:NamedThing guanosine deaminase activity Catalysis of the reaction: guanosine + H2O = xanthosine + NH3. got7fsn_ti guanosine aminohydrolase activity|guanosine aminase activity MetaCyc:GUANOSINE-DEAMINASE-RXN|RHEA:12861|EC:3.5.4.15 molecular_function owl:Class
GO:0103012 biolink:NamedThing ferredoxin-thioredoxin reductase activity Catalysis of the reaction: 2 H+ + 2 a reduced ferredoxin + an oxidized thioredoxin = 2 an oxidized ferredoxin + a reduced thioredoxin, involving a 4Fe-4S cluster and an adjacent active-site disulfide. got7fsn_ti ferredoxin:thioredoxin reductase activity https://github.com/geneontology/go-ontology/issues/18939 GO:0030385 EC:1.8.7.2|MetaCyc:RXN-9944|RHEA:42336 molecular_function owl:Class
GO:0033716 biolink:NamedThing nucleoside oxidase (hydrogen peroxide-forming) activity Catalysis of the reactions: adenosine + 2 O2 = 9-riburonosyladenine + 2 hydrogen peroxide. got7fsn_ti nucleoside:oxygen 5'-oxidoreductase (hydrogen peroxide-forming) activity Two other reactions might be associated with this activity: (1a) adenosine + O2 = 5'-dehydroadenosine + hydrogen peroxide, and (1b) 5'-dehydroadenosine + O2 = 9-riburonosyladenine + hydrogen peroxide. MetaCyc:1.1.3.39-RXN|EC:1.1.3.39|RHEA:15489 molecular_function owl:Class
GO:0005152 biolink:NamedThing interleukin-1 receptor antagonist activity Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. got7fsn_ti IL-1ra molecular_function owl:Class
GO:0048847 biolink:NamedThing adenohypophysis formation The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus. got7fsn_ti anterior pituitary gland formation|anterior pituitary biosynthesis|anterior pituitary gland biosynthesis|anterior pituitary formation|adenophysis formation|adenophysis biosynthesis biological_process owl:Class
GO:0030193 biolink:NamedThing regulation of blood coagulation Any process that modulates the frequency, rate or extent of blood coagulation. got7fsn_ti biological_process owl:Class
GO:0061041 biolink:NamedThing regulation of wound healing Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. got7fsn_ti dph 2010-02-25T10:14:37Z biological_process owl:Class
GO:1990144 biolink:NamedThing intrinsic apoptotic signaling pathway in response to hypoxia A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered. got7fsn_ti pr 2013-07-23T10:18:10Z biological_process owl:Class
GO:0102128 biolink:NamedThing chalcone synthase activity Catalysis of the reaction: 4-dihydrocoumaroyl-CoA + 3 malonyl-CoA + 3 H+ = phloretin + 4 coenzyme A + 3 carbon dioxide. got7fsn_ti MetaCyc:RXN-11468|EC:2.3.1.74 molecular_function owl:Class
GO:0030233 biolink:NamedThing deoxynucleotide transmembrane transporter activity Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP. got7fsn_ti molecular_function owl:Class
GO:0015215 biolink:NamedThing nucleotide transmembrane transporter activity Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0031287 biolink:NamedThing positive regulation of sorocarp stalk cell differentiation Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum. got7fsn_ti positive regulation of stalk cell differentiation|upregulation of stalk cell differentiation|up-regulation of stalk cell differentiation|stimulation of stalk cell differentiation|activation of stalk cell differentiation|up regulation of stalk cell differentiation biological_process owl:Class
GO:0032109 biolink:NamedThing positive regulation of response to nutrient levels Any process that activates or increases the frequency, rate or extent of a response to nutrient levels. got7fsn_ti stimulation of response to nutrient levels|up-regulation of response to nutrient levels|activation of response to nutrient levels|upregulation of response to nutrient levels|up regulation of response to nutrient levels biological_process owl:Class
GO:0034791 biolink:NamedThing isobutylamine N-hydroxylase activity Catalysis of the reaction: isobutylamine + NADPH + O2 = isobutylhydroxylamine + NADP+ + H2O. got7fsn_ti EC:1.14.13.-|UM-BBD_reactionID:r1053 molecular_function owl:Class
GO:0006975 biolink:NamedThing DNA damage induced protein phosphorylation The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage. got7fsn_ti biological_process owl:Class
GO:0102279 biolink:NamedThing lecithin:11-cis retinol acyltransferase activity Catalysis of the reaction: an 11-cis retinol-[cellular-retinol-binding-protein] + a phosphatidylcholine <=> a cellular-retinol-binding protein + an 11-cis-retinyl ester + a 1-lysophosphatidylcholine. got7fsn_ti EC:2.3.1.135|MetaCyc:RXN-12563 molecular_function owl:Class
GO:2001002 biolink:NamedThing positive regulation of xylan catabolic process Any process that activates or increases the frequency, rate or extent of xylan catabolic process. got7fsn_ti positive regulation of xylan catabolism|positive regulation of xylan degradation|positive regulation of xylan breakdown tt 2011-08-08T03:23:22Z biological_process owl:Class
GO:2000926 biolink:NamedThing positive regulation of cellodextrin metabolic process Any process that activates or increases the frequency, rate or extent of cellodextrin metabolic process. got7fsn_ti positive regulation of cellodextrin metabolism tt 2011-08-01T12:39:59Z biological_process owl:Class
GO:0102710 biolink:NamedThing D-inositol-3-phosphate glycosyltransferase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + 1D-myo-inositol 3-phosphate = 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + UDP + H+. got7fsn_ti EC:2.4.1.250|MetaCyc:RXN-6501|RHEA:26188 molecular_function owl:Class
GO:0097411 biolink:NamedThing hypoxia-inducible factor-1alpha signaling pathway A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. got7fsn_ti HIF1alpha pathway|hypoxia-inducible factor signaling|hypoxia-inducible factor-1alpha signalling pathway pr 2012-11-06T10:46:33Z biological_process owl:Class
GO:2000856 biolink:NamedThing negative regulation of mineralocorticoid secretion Any process that stops, prevents or reduces the frequency, rate or extent of mineralocorticoid secretion. got7fsn_ti bf 2011-07-26T08:46:42Z biological_process owl:Class
GO:0018513 biolink:NamedThing dibenzothiophene dihydrodiol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH. got7fsn_ti cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity UM-BBD_reactionID:r0161|EC:1.3.1.60|KEGG_REACTION:R05310|RHEA:24188|MetaCyc:1.3.1.60-RXN molecular_function owl:Class
GO:0090695 biolink:NamedThing Wpl/Pds5 cohesin loading/unloading complex A eukaryotically conserved heterodimeric protein complex (comprising Wings apart-like protein and the Pds5 Armadillo repeat cohesin associated protein) involved in the loading and unloading of a cohesin complex onto DNA. got7fsn_ti tb 2016-08-24T17:09:11Z cellular_component owl:Class
GO:0031501 biolink:NamedThing mannosyltransferase complex A complex that posseses mannosyltransferase activity. got7fsn_ti cellular_component owl:Class
GO:0001703 biolink:NamedThing gastrulation with mouth forming first A gastrulation process in which the initial invagination becomes the mouth and the anus forms second. got7fsn_ti protostomic gastrulation biological_process owl:Class
GO:0005118 biolink:NamedThing sevenless binding Binding to a sevenless (sev) protein, a receptor tyrosine kinase. got7fsn_ti sev ligand|sevenless ligand|sev binding molecular_function owl:Class
GO:0002482 biolink:NamedThing antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent|TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib|TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib biological_process owl:Class
GO:0004423 biolink:NamedThing iduronate-2-sulfatase activity Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. got7fsn_ti iduronide-2-sulfate sulfatase activity|iduronate-2-sulfate sulfatase activity|iduronate-2-sulphatase activity|chondroitinsulfatase|L-iduronate 2-sulfate sulfatase activity|iduronate sulfatase activity|sulfoiduronate sulfohydrolase activity|L-idurono sulfate sulfatase activity|2-sulfo-L-iduronate 2-sulfatase activity|sulfo-L-iduronate sulfatase activity|iduronate sulfate sulfatase activity|idurono-2-sulfatase activity|L-iduronate-2-sulfate 2-sulfohydrolase activity|L-iduronosulfatase activity MetaCyc:3.1.6.13-RXN|EC:3.1.6.13|Reactome:R-HSA-9036046|Reactome:R-HSA-1793182|Reactome:R-HSA-1678650|Reactome:R-HSA-2262743 molecular_function owl:Class
GO:0014065 biolink:NamedThing phosphatidylinositol 3-kinase signaling A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions. got7fsn_ti PI 3-kinase cascade|PI3K signaling|PI3K cascade|phosphatidylinositol 3-kinase signal transduction|phosphatidylinositol 3-kinase cascade|phosphoinositide 3-kinase cascade|PI3K signal transduction biological_process owl:Class
GO:0048015 biolink:NamedThing phosphatidylinositol-mediated signaling A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. got7fsn_ti inositol phospholipid-mediated signaling|phosphatidylinositol-mediated signal transduction|phosphoinositide-mediated signalling|phosphatidylinositol-mediated signalling|phosphoinositide-mediated signaling biological_process owl:Class
GO:0008760 biolink:NamedThing UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. got7fsn_ti phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity|enoylpyruvate transferase activity|pyruvate-uridine diphospho-N-acetylglucosamine transferase activity|pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity|phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity|UDP-N-acetylglucosamine enoylpyruvyltransferase activity|pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity|MurA transferase activity|UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity|phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity|phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity|phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity|phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity|pyruvate-UDP-acetylglucosamine transferase activity RHEA:18681|EC:2.5.1.7|MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN|KEGG_REACTION:R00660 molecular_function owl:Class
GO:0004378 biolink:NamedThing GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage. got7fsn_ti glycolipid 3-alpha-mannosyltransferase activity|guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity|GDP-mannose-oligosaccharide-lipid mannosyltransferase II|GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity|mannosyltransferase II activity|GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity RHEA:29515|EC:2.4.1.132|MetaCyc:2.4.1.132-RXN molecular_function owl:Class
GO:0047873 biolink:NamedThing dolichyl-phosphatase activity Catalysis of the reaction: dolichyl phosphate + H2O = dolichol + phosphate. got7fsn_ti dolichyl-phosphate phosphohydrolase activity|dolichol phosphate phosphatase activity|dolichyl pyrophosphate phosphatase activity|Dol-P-P phosphohydrolase activity|dolichyl monophosphate phosphatase activity|dolichol phosphatase activity|dolichol monophosphatase activity|polyprenylphosphate phosphatase activity|dolichyl phosphate phosphatase activity|Dol-P phosphatase activity|polyisoprenyl phosphate phosphatase activity MetaCyc:DOLICHYL-PHOSPHATASE-RXN|EC:3.1.3.51|RHEA:13797 molecular_function owl:Class
GO:0060417 biolink:NamedThing yolk The cytoplasmic part that serves as a nutrient reserve or energy source for the developing embryo. got7fsn_ti cellular_component owl:Class
GO:0033461 biolink:NamedThing GGU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GGU codon. got7fsn_ti glycine tRNA|GGT codon-amino acid adaptor activity Note that in the standard genetic code, GGT codes for glycine. molecular_function owl:Class
GO:0004535 biolink:NamedThing poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. got7fsn_ti 2',3'-exoribonuclease activity|3'-exoribonuclease activity|poly(A)-specific RNase activity Reactome:R-HSA-429992|EC:3.1.13.4|Reactome:R-HSA-429955|MetaCyc:3.1.13.4-RXN|Reactome:R-HSA-430021 molecular_function owl:Class
GO:0070855 biolink:NamedThing myosin VI head/neck binding Binding to the head/neck region of a myosin VI heavy chain. got7fsn_ti mah 2009-08-13T01:45:08Z molecular_function owl:Class
GO:0102037 biolink:NamedThing 4-nitrotoluene monooxygenase activity Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 <=> 4-nitrobenzyl alcohol + NAD+ + H2O. got7fsn_ti MetaCyc:R361-RXN molecular_function owl:Class
GO:0003220 biolink:NamedThing left ventricular cardiac muscle tissue morphogenesis The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized. got7fsn_ti left ventricular myocardium morphogenesis dph 2009-10-13T10:18:05Z biological_process owl:Class
GO:0050013 biolink:NamedThing 2-dehydropantoate aldolase activity Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde. got7fsn_ti 2-dehydropantoate formaldehyde-lyase activity|ketopantoaldolase activity|2-dehydropantoate formaldehyde-lyase (3-methyl-2-oxobutanoate-forming) RHEA:23276|EC:4.1.2.12|MetaCyc:KETOPANTOALDOLASE-RXN molecular_function owl:Class
GO:0038047 biolink:NamedThing morphine receptor activity Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti mu-opioid receptor activity bf 2011-11-14T01:35:18Z molecular_function owl:Class
GO:0070113 biolink:NamedThing organellar chromatophore inner membrane The inner, i.e. lumen-facing, of the two lipid bilayers surrounding an organellar chromatophore. got7fsn_ti Paulinella-type chromatophore inner membrane cellular_component owl:Class
GO:0070112 biolink:NamedThing organellar chromatophore membrane Either of the lipid bilayers that surround an organellar chromatophore. got7fsn_ti Paulinella-type chromatophore membrane cellular_component owl:Class
GO:0021717 biolink:NamedThing inferior olivary nucleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. got7fsn_ti inferior olive maturation biological_process owl:Class
GO:0106144 biolink:NamedThing fraxetin 5-hydroxylase activity Catalyzes the reaction fraxetin+ NAD(P)H + 02= sideretin + NAD(P)(+) + H20. got7fsn_ti hjd 2018-09-07T18:24:41Z RHEA:57844|EC:1.14.14.164 molecular_function owl:Class
GO:0036427 biolink:NamedThing all-trans-undecaprenyl-phosphate mannosyltransferase activity Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP. got7fsn_ti bf 2013-09-16T13:23:06Z RHEA:28118 molecular_function owl:Class
GO:0047267 biolink:NamedThing undecaprenyl-phosphate mannosyltransferase activity Catalysis of the reaction: GDP-mannose + undecaprenyl phosphate = GDP + D-mannosyl-1-phosphoundecaprenol. got7fsn_ti GDP mannose-undecaprenyl phosphate mannosyltransferase activity|GDP-mannose:undecaprenyl-phosphate D-mannosyltransferase activity|GDP-D-mannose:lipid phosphate transmannosylase activity|guanosine diphosphomannose-undecaprenyl phosphate mannosyltransferase activity EC:2.4.1.54 molecular_function owl:Class
GO:0047950 biolink:NamedThing glutathione oxidase activity Catalysis of the reaction: 2 glutathione + O(2) = glutathione disulfide + H(2)O(2). got7fsn_ti glutathione:oxygen oxidoreductase activity EC:1.8.3.3|KEGG_REACTION:R00120|MetaCyc:GLUTATHIONE-OXIDASE-RXN|RHEA:24112 molecular_function owl:Class
GO:0090433 biolink:NamedThing palmitoyl-CoA ligase activity Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA. got7fsn_ti palmitoyl-CoA synthetase activity tb 2012-07-25T03:31:31Z Reactome:R-HSA-434382 molecular_function owl:Class
GO:0043886 biolink:NamedThing structural constituent of carboxysome The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in all cyanobacteria and some chemoautotrophs, consisting of a proteinaceous coat and enzymes for the fixation of CO(2). got7fsn_ti https://github.com/geneontology/go-ontology/issues/19743 molecular_function owl:Class
GO:0010618 biolink:NamedThing aerenchyma formation The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti biological_process owl:Class
GO:0016235 biolink:NamedThing aggresome An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules. got7fsn_ti Wikipedia:Aggresome cellular_component owl:Class
GO:0042660 biolink:NamedThing positive regulation of cell fate specification Any process that activates or enables a cell to adopt a specific fate. got7fsn_ti up regulation of cell fate specification|activation of cell fate specification|upregulation of cell fate specification|stimulation of cell fate specification|up-regulation of cell fate specification biological_process owl:Class
GO:0044100 biolink:NamedThing sporoplasm The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms. got7fsn_ti jl 2009-06-09T03:27:03Z cellular_component owl:Class
GO:0052885 biolink:NamedThing all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid. got7fsn_ti all-trans-retinol isomerase:hydrolase activity|all-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity|retinoid isomerohydrolase activity|all-trans-retinylester 11-cis isomerohydrolase activity|retinol isomerase activity EC:3.1.1.64|RHEA:31771|MetaCyc:RXN-12550|KEGG_REACTION:R08388 molecular_function owl:Class
GO:1990877 biolink:NamedThing Lst4-Lst7 complex A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains Follicular (FLCN) and either follicular interaction protein 1 (FNIP1) or FNIP2. got7fsn_ti FNIP-Folliculin RagC/D GAP complex|FLCN-FNIP1 complex|FLCN-FNIP2 complex rb 2015-10-01T22:44:58Z cellular_component owl:Class
GO:0047709 biolink:NamedThing bis(2-ethylhexyl)phthalate esterase activity Catalysis of the reaction: bis(2-ethylhexyl)phthalate + H(2)O = 2-ethylhexan-1-ol + 2-ethylhexyl phthalate + H(+). got7fsn_ti DEHP esterase activity|bis(2-ethylhexyl)phthalate acylhydrolase activity KEGG_REACTION:R04202|MetaCyc:BIS2-ETHYLHEXYLPHTHALATE-ESTERASE-RXN|EC:3.1.1.60|RHEA:15529 molecular_function owl:Class
GO:0032499 biolink:NamedThing detection of peptidoglycan The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule. got7fsn_ti biological_process owl:Class
GO:0032494 biolink:NamedThing response to peptidoglycan Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule. got7fsn_ti biological_process owl:Class
GO:0004458 biolink:NamedThing D-lactate dehydrogenase (cytochrome) activity Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. got7fsn_ti cytochrome-dependent D-(-)-lactate dehydrogenase activity|D-(-)-lactic cytochrome c reductase activity|lactic acid dehydrogenase activity|D-lactate ferricytochrome c oxidoreductase activity|D-lactate-cytochrome c reductase activity|(R)-lactate:ferricytochrome-c 2-oxidoreductase activity|D-lactate (cytochrome) dehydrogenase activity RHEA:13521|MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN|EC:1.1.2.4 molecular_function owl:Class
GO:0102216 biolink:NamedThing maltodextrin water dikinase Catalysis of the reaction: ATP + H2O + a maltodextrin = AMP + hydrogenphosphate + a 6-phosphogluco-maltodextrin. got7fsn_ti MetaCyc:RXN-12201|EC:2.7.9.4 molecular_function owl:Class
GO:0060716 biolink:NamedThing labyrinthine layer blood vessel development The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply. got7fsn_ti dph 2009-06-11T09:04:38Z biological_process owl:Class
GO:0006517 biolink:NamedThing protein deglycosylation The removal of sugar residues from a glycosylated protein. got7fsn_ti glycoprotein deglycosylation biological_process owl:Class
GO:0061990 biolink:NamedThing beta-ketodecanoyl-[acyl-carrier-protein] synthase activity Catalysis of the reaction: octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2. got7fsn_ti dph 2018-02-15T22:29:03Z RHEA:42264|MetaCyc:RXN-13613 molecular_function owl:Class
GO:0042709 biolink:NamedThing succinate-CoA ligase complex A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP. got7fsn_ti cellular_component owl:Class
GO:0033660 biolink:NamedThing suppression by symbiont of host resistance gene-dependent defense response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the resistance gene-dependent defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti down-regulation by symbiont of host gene-for-gene resistance|suppression by symbiont of host resistance gene-dependent defense response|downregulation by symbiont of pathogen-race/host plant cultivar-specific resistance in symbiont|down regulation by symbiont of defense response in host by specific elicitors|inhibition by symbiont of host resistance gene-dependent defense response|negative regulation by symbiont of host resistance gene-dependent defense response biological_process owl:Class
GO:0070889 biolink:NamedThing platelet alpha granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet alpha granule. A platelet alpha granule is a secretory organelle found in blood platelets. got7fsn_ti platelet alpha granule organization and biogenesis|platelet alpha granule organisation|platelet alpha-granule organization mah 2009-08-28T10:43:31Z biological_process owl:Class
GO:0031593 biolink:NamedThing polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination of the target protein. got7fsn_ti molecular_function owl:Class
GO:0039689 biolink:NamedThing negative stranded viral RNA replication A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA). got7fsn_ti (-)ss viral RNA replication bf 2013-10-17T15:40:27Z VZ:1096 biological_process owl:Class
GO:0039694 biolink:NamedThing viral RNA genome replication The replication of a viral RNA genome. got7fsn_ti bf 2013-10-23T15:24:36Z biological_process owl:Class
GO:0050078 biolink:NamedThing malonate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA. got7fsn_ti acetyl-CoA:malonate CoA-transferase activity|malonate coenzyme A-transferase activity KEGG_REACTION:R00743|RHEA:18817|MetaCyc:MALONATE-COA-TRANSFERASE-RXN|EC:2.8.3.3 molecular_function owl:Class
GO:0047163 biolink:NamedThing 3,4-dichloroaniline N-malonyltransferase activity Catalysis of the reaction: 3,4-dichloroaniline + malonyl-CoA = N-(3,4-dichlorophenyl)malonamate + CoA. got7fsn_ti malonyl-CoA:3,4-dichloroaniline N-malonyltransferase activity EC:2.3.1.114|RHEA:21060|MetaCyc:2.3.1.114-RXN|KEGG_REACTION:R04050 molecular_function owl:Class
GO:0018177 biolink:NamedThing protein uridylylation The addition of phospho-uridine to a protein amino acid. got7fsn_ti protein amino acid uridylylation biological_process owl:Class
GO:0009327 biolink:NamedThing NAD(P)+ transhydrogenase complex (AB-specific) A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified. got7fsn_ti cellular_component owl:Class
GO:0002188 biolink:NamedThing translation reinitiation A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon. got7fsn_ti hjd 2011-06-22T12:31:13Z biological_process owl:Class
GO:0071951 biolink:NamedThing conversion of methionyl-tRNA to N-formyl-methionyl-tRNA The modification process that results in the conversion of methionine charged on a tRNA(fMet) to N-formyl-methionine-tRNA(fMet). got7fsn_ti mah 2010-10-08T11:54:38Z biological_process owl:Class
GO:0102675 biolink:NamedThing C4-methyltransferase activity Catalysis of the reaction: 24-ethylidenelophenol + a demethylated methyl acceptor <=> avenasterol + a methylated methyl acceptor. got7fsn_ti MetaCyc:RXN-4208 molecular_function owl:Class
GO:1902489 biolink:NamedThing hepatoblast apoptotic process Any apoptotic process in a hepatoblast. got7fsn_ti hepatoblast apoptosis cls 2013-11-12T17:02:52Z biological_process owl:Class
GO:0043739 biolink:NamedThing G/U mismatch-specific uracil-DNA glycosylase activity Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site. got7fsn_ti uracil mismatch repair protein|MUG|GU mismatch-specific uracil-DNA glycosylase activity molecular_function owl:Class
GO:0015574 biolink:NamedThing trehalose transmembrane transporter activity Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens. got7fsn_ti trehalose permease activity GO:0015584 molecular_function owl:Class
GO:0051542 biolink:NamedThing elastin biosynthetic process The chemical reactions and pathways resulting in the formation of elastin, a fibrous glycoprotein found in elastic tissues such as the walls of arteries. got7fsn_ti biological_process owl:Class
GO:0051541 biolink:NamedThing elastin metabolic process The chemical reactions and pathways involving elastin, a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue. got7fsn_ti elastin metabolism biological_process owl:Class
GO:0044733 biolink:NamedThing envenomation resulting in modulation of acid-sensing ion channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism. got7fsn_ti envenomation resulting in modulation of ASIC channel activity in other organism jl 2012-11-06T15:58:36Z biological_process owl:Class
GO:0090572 biolink:NamedThing RNA polymerase III transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter. got7fsn_ti tb 2014-05-09T13:26:16Z cellular_component owl:Class
GO:0000309 biolink:NamedThing nicotinamide-nucleotide adenylyltransferase activity Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+. got7fsn_ti adenosine triphosphate-nicotinamide mononucleotide transadenylase activity|NAD+ pyrophosphorylase activity|diphosphopyridine nucleotide pyrophosphorylase activity|NAD(+) pyrophosphorylase activity|NMNAT activity|ATP:nicotinamide-nucleotide adenylyltransferase activity|nicotinamide adenine dinucleotide pyrophosphorylase activity|nicotinamide mononucleotide adenylyltransferase activity|NMN adenylyltransferase activity|NAD(+) diphosphorylase activity|ATP:NMN adenylyltransferase activity|NAD+ diphosphorylase activity Reactome:R-HSA-8939959|RHEA:21360|MetaCyc:2.7.7.1-RXN|EC:2.7.7.1 molecular_function owl:Class
GO:0050586 biolink:NamedThing 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO. got7fsn_ti (1H)-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity|3-hydroxy-2-methyl-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)|1H-3-hydroxy-4-oxo quinaldine 2,4-dioxygenase activity|3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase activity|1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase activity MetaCyc:1.13.11.48-RXN|RHEA:21572|KEGG_REACTION:R05720|EC:1.13.11.48 molecular_function owl:Class
GO:0051145 biolink:NamedThing smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary. got7fsn_ti nonstriated muscle cell differentiation biological_process owl:Class
GO:1990079 biolink:NamedThing cartilage homeostasis A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function. got7fsn_ti regulation of cartilage homeostasis|positive regulation of cartilage homeostasis|negative regulation of cartilage homeostasis hjd 2013-04-29T20:10:15Z GO:1902095|GO:1902096|GO:1902094 biological_process owl:Class
GO:0044095 biolink:NamedThing host cell nucleoplasm That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction. got7fsn_ti jl 2009-04-22T02:02:51Z cellular_component owl:Class
GO:0061986 biolink:NamedThing negative regulation of transcription by glucose Any process involving glucose that decreases the frequency, rate or extent or transcription. got7fsn_ti dph 2018-02-15T17:39:14Z biological_process owl:Class
GO:0071055 biolink:NamedThing alpha9-beta1 integrin-ADAM9 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM9. got7fsn_ti ITGA9-ITGB1-ADAM9 complex mah 2009-11-03T03:59:24Z cellular_component owl:Class
GO:0033006 biolink:NamedThing regulation of mast cell activation involved in immune response Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response. got7fsn_ti regulation of mast cell activation during immune response biological_process owl:Class
GO:0042984 biolink:NamedThing regulation of amyloid precursor protein biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of amyloid-beta. got7fsn_ti regulation of amyloid precursor protein anabolism|regulation of amyloid precursor protein synthesis|regulation of amyloid precursor protein biosynthesis|regulation of APP biosynthesis|regulation of APP biosynthetic process|regulation of amyloid precursor protein formation biological_process owl:Class
GO:0010559 biolink:NamedThing regulation of glycoprotein biosynthetic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide. got7fsn_ti biological_process owl:Class
GO:0030749 biolink:NamedThing loganate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin. got7fsn_ti S-adenosyl-L-methionine:loganic acid methyltransferase activity|S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity|loganate methyltransferase activity RHEA:12508|MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN|EC:2.1.1.50 molecular_function owl:Class
GO:0034461 biolink:NamedThing uropod retraction The process in which a uropod detaches from the cell substrate and retracts the rear of a migrating cell. got7fsn_ti biological_process owl:Class
GO:0032796 biolink:NamedThing uropod organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated. got7fsn_ti uropod organisation|uropod organization and biogenesis biological_process owl:Class
GO:0106298 biolink:NamedThing 13-series resolvin biosynthetic process The chemical reactions and pathways resulting in the formation of resolvin family 13-series, hydroxy fatty acids derived from docosapentaenoic acid. got7fsn_ti hjd 2020-08-25T13:50:53Z biological_process owl:Class
GO:0047148 biolink:NamedThing methylamine-glutamate N-methyltransferase activity Catalysis of the reaction: L-glutamate + methylammonium = N-methyl-L-glutamate + NH(4)(+). got7fsn_ti methylamine-glutamate methyltransferase activity|N-methylglutamate synthase activity|methylamine:L-glutamate N-methyltransferase activity RHEA:15837|KEGG_REACTION:R01586|EC:2.1.1.21|MetaCyc:2.1.1.21-RXN molecular_function owl:Class
GO:0050304 biolink:NamedThing nitrous-oxide reductase activity Catalysis of the reaction: H(2)O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide. got7fsn_ti nitrogen:acceptor oxidoreductase (N2O-forming)|nitrous oxide reductase activity|N2O reductase activity|nitrogen:(acceptor) oxidoreductase (N2O-forming) EC:1.7.2.4|KEGG_REACTION:R02804|RHEA:43108|MetaCyc:RXN-12130 molecular_function owl:Class
GO:0016662 biolink:NamedThing oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome. got7fsn_ti EC:1.7.2.- molecular_function owl:Class
GO:0003839 biolink:NamedThing gamma-glutamylcyclotransferase activity Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid. got7fsn_ti gamma-glutamyl-amino acid cyclotransferase activity|(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)|L-glutamic cyclase activity|gamma-L-glutamylcyclotransferase activity EC:4.3.2.9|Reactome:R-HSA-6785928|RHEA:20505|MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN|Reactome:R-HSA-1247922 molecular_function owl:Class
GO:0140024 biolink:NamedThing plus-end-directed endosome transport along mitotic spindle midzone microtubule The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination. got7fsn_ti pg 2017-04-29T11:34:23Z biological_process owl:Class
GO:1990256 biolink:NamedThing signal clustering Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response. got7fsn_ti ligand clustering tb 2013-12-18T01:13:59Z biological_process owl:Class
GO:0099618 biolink:NamedThing UDP-glucuronic acid dehydrogenase activity Catalysis of the reaction: UDP-glucuronate + NAD+ = UDP-beta-L-threo-pentapyranos-4-ulose + CO2 + NADH + H+. got7fsn_ti UDP-GlcUA decarboxylase activity RHEA:24702|EC:1.1.1.305 molecular_function owl:Class
GO:1903038 biolink:NamedThing negative regulation of leukocyte cell-cell adhesion Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion. got7fsn_ti down regulation of leukocyte cell-cell adhesion|inhibition of leukocyte cell-cell adhesion|down-regulation of leukocyte cell adhesion|down-regulation of leukocyte cell-cell adhesion|downregulation of leukocyte cell adhesion|inhibition of leukocyte adhesion|down regulation of leukocyte cell adhesion|negative regulation of leukocyte cell adhesion|negative regulation of leukocyte adhesion|downregulation of leukocyte adhesion|down regulation of leukocyte adhesion|down-regulation of leukocyte adhesion|downregulation of leukocyte cell-cell adhesion|inhibition of leukocyte cell adhesion Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion rl 2014-05-19T15:30:05Z biological_process owl:Class
GO:0052089 biolink:NamedThing modulation by symbiont of host salicylic acid-mediated defense response Any process in which a symbiont modulates the frequency, rate or extent of the salicylic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of host SA-mediated defense response|modulation by organism of salicylic acid-mediated defense response of other organism involved in symbiotic interaction GO:0052284 biological_process owl:Class
GO:2000031 biolink:NamedThing regulation of salicylic acid mediated signaling pathway Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway. got7fsn_ti regulation of salicylic acid mediated signalling pathway tb 2010-08-05T11:32:24Z biological_process owl:Class
GO:0044555 biolink:NamedThing negative regulation of heart rate in other organism Any process that stops, prevents or reduces the frequency of heart contraction of another organism. got7fsn_ti jl 2012-03-29T03:01:20Z biological_process owl:Class
GO:0042075 biolink:NamedThing nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase. got7fsn_ti nickel incorporation into nickel-iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide RESID:AA0310 biological_process owl:Class
GO:0010303 biolink:NamedThing limit dextrinase activity Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan. got7fsn_ti R-enzyme|dextrin alpha-1,6-glucanohydrolase activity|amylopectin-1,6-glucosidase activity MetaCyc:3.2.1.142-RXN|MetaCyc:RXN-1824|MetaCyc:3.2.1.10-RXN|EC:3.2.1.142 molecular_function owl:Class
GO:0031832 biolink:NamedThing type 6 serotonin receptor binding Binding to a type 6 serotonin receptor. got7fsn_ti 5-hydroxytryptamine 6 receptor binding|type 6 serotonin receptor ligand molecular_function owl:Class
GO:0034906 biolink:NamedThing N-isopropylaniline 1,2-dixoxygenase activity Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine. got7fsn_ti UM-BBD_reactionID:r0721|EC:1.14.12.- molecular_function owl:Class
GO:0098671 biolink:NamedThing adhesion receptor-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that does not mediate or trigger entry into the host cell. This binding is typically reversible and enhances significantly infectivity by concentrating the virus in the vicinity of its entry receptors, or bringing it to an organ in which its target cells are located. got7fsn_ti viral attachment to host adhesion receptor dos 2017-01-16T13:22:54Z VZ:3943 biological_process owl:Class
GO:0102784 biolink:NamedThing lutein oxygenase activity Catalysis of the reaction: lutein + 2 O2 = 3-hydroxy-beta-ionone + 3-hydroxy-alpha-ionone + 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial. got7fsn_ti MetaCyc:RXN-7884 molecular_function owl:Class
GO:0048564 biolink:NamedThing photosystem I assembly The aggregation, arrangement and bonding together of a set of components to form a photosystem I complex on the thylakoid membrane. got7fsn_ti GO:0010251 biological_process owl:Class
GO:0097477 biolink:NamedThing lateral motor column neuron migration The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme. got7fsn_ti pr 2013-04-23T13:05:32Z biological_process owl:Class
GO:0097476 biolink:NamedThing spinal cord motor neuron migration The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement. got7fsn_ti pr 2013-04-23T13:03:46Z biological_process owl:Class
GO:0018815 biolink:NamedThing 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine. got7fsn_ti UM-BBD_reactionID:r0051|MetaCyc:RXN-645 molecular_function owl:Class
GO:0022878 biolink:NamedThing protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti sucrose PTS transporter activity RHEA:49236|MetaCyc:SUCROSEPHOSPHO-RXN molecular_function owl:Class
GO:0090179 biolink:NamedThing planar cell polarity pathway involved in neural tube closure The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure. got7fsn_ti tb 2009-12-14T11:20:27Z biological_process owl:Class
GO:0090178 biolink:NamedThing regulation of establishment of planar polarity involved in neural tube closure Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube. got7fsn_ti tb 2009-12-14T11:14:27Z biological_process owl:Class
GO:0047868 biolink:NamedThing dimethylmaleate hydratase activity Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O. got7fsn_ti (2R,3S)-2,3-dimethylmalate hydro-lyase activity|(2R,3S)-2,3-dimethylmalate hydro-lyase (dimethylmaleate-forming) MetaCyc:DIMETHYLMALEATE-HYDRATASE-RXN|KEGG_REACTION:R03069|EC:4.2.1.85|RHEA:20253 molecular_function owl:Class
GO:0060384 biolink:NamedThing innervation The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue. got7fsn_ti biological_process owl:Class
GO:0036070 biolink:NamedThing light-independent bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants. got7fsn_ti light independent bacteriochlorophyll biosynthetic process|light-independent bacteriochlorophyll synthesis|light-independent bacteriochlorophyll biosynthesis|light-independent bacteriochlorophyll formation|light-independent bacteriochlorophyll anabolism bf 2011-12-15T04:46:25Z biological_process owl:Class
GO:0110012 biolink:NamedThing protein localization to P-body Any process in which a protein is transported to, or maintained at, a P-body. got7fsn_ti protein localization to P body|protein localization to cytoplasmic mRNA processing body|protein localisation to P-body kmv 2017-05-03T14:04:51Z biological_process owl:Class
GO:0050004 biolink:NamedThing isoflavone 7-O-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside. got7fsn_ti uridine diphosphoglucose-isoflavone 7-O-glucosyltransferase activity|UDPglucose-flavonoid 7-O-glucosyltransferase activity|UDP-glucose:isoflavone 7-O-beta-D-glucosyltransferase activity|UDPglucose:isoflavone 7-O-glucosyltransferase activity|UDPglucose:isoflavone 7-O-beta-D-glucosyltransferase activity MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN|EC:2.4.1.170|RHEA:56344 molecular_function owl:Class
GO:0033963 biolink:NamedThing cholesterol-5,6-oxide hydrolase activity Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol. got7fsn_ti cholesterol-epoxide hydrolase activity|5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity|ChEH EC:3.3.2.11|MetaCyc:RXN-8651|MetaCyc:RXN-8650 molecular_function owl:Class
GO:0034027 biolink:NamedThing (carboxyethyl)arginine beta-lactam-synthase activity Catalysis of the reaction: N(2)-(2-carboxyethyl)-L-arginine + ATP = AMP + deoxyamidinoproclavaminate + diphosphate + 2 H(+). got7fsn_ti beta-lactam synthetase activity|L-N2-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity|L-2-N-(2-carboxyethyl)arginine cyclo-ligase (AMP-forming) activity RHEA:23620|EC:6.3.3.4|MetaCyc:6.3.3.4-RXN|KEGG_REACTION:R05467 molecular_function owl:Class
GO:0016882 biolink:NamedThing cyclo-ligase activity Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti EC:6.3.3.- molecular_function owl:Class
GO:0039627 biolink:NamedThing T=147 icosahedral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins. got7fsn_ti bf 2012-08-03T16:18:49Z cellular_component owl:Class
GO:0046566 biolink:NamedThing DOPA dioxygenase activity Catalysis of the 4,5-ring opening reaction: 3,4-dihydroxyphenylalanine + O2 = 4,5-seco-DOPA. 4,5-seco-DOPA spontaneously recyclizes to form betalamic acid. got7fsn_ti dihydroxyphenylalanine dioxygenase activity MetaCyc:RXN-8460 molecular_function owl:Class
GO:0036359 biolink:NamedThing renal potassium excretion The elimination by an organism of potassium in the urine. got7fsn_ti renal K+ elimination|renal K(+) excretion|renal potassium ion excretion bf 2012-09-20T11:10:47Z biological_process owl:Class
GO:1902586 biolink:NamedThing multi-organism intercellular transport An intercellular transport which involves another organism. got7fsn_ti multi organism intercellular transport jl 2013-12-19T13:25:05Z biological_process owl:Class
GO:0090327 biolink:NamedThing negative regulation of locomotion involved in locomotory behavior Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. got7fsn_ti tb 2010-05-14T10:26:58Z biological_process owl:Class
GO:0070989 biolink:NamedThing oxidative demethylation The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate. got7fsn_ti mah 2009-10-29T03:33:25Z biological_process owl:Class
GO:0070988 biolink:NamedThing demethylation The process of removing one or more methyl groups from a molecule. got7fsn_ti mah 2009-10-29T03:12:51Z biological_process owl:Class
GO:0021642 biolink:NamedThing trochlear nerve formation The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. got7fsn_ti CN IV biosynthesis|CN IV formation biological_process owl:Class
GO:0010050 biolink:NamedThing vegetative phase change Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development. got7fsn_ti biological_process owl:Class
GO:0030736 biolink:NamedThing phenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+). got7fsn_ti PMT|S-adenosyl-L-methionine:phenol O-methyltransferase activity KEGG_REACTION:R01239|RHEA:14809|EC:2.1.1.25|MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0038017 biolink:NamedThing Wnt receptor internalization A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell. got7fsn_ti Wnt receptor endocytosis bf 2011-06-23T04:25:47Z biological_process owl:Class
GO:0004915 biolink:NamedThing interleukin-6 receptor activity Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-6 receptor activity|IL-6R|gp130 molecular_function owl:Class
GO:0030943 biolink:NamedThing mitochondrion targeting sequence binding Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion. got7fsn_ti mitochondrial targeting sequence binding molecular_function owl:Class
GO:0004526 biolink:NamedThing ribonuclease P activity Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. got7fsn_ti tRNA 5' leader endonuclease activity|RNase P Reactome:R-HSA-5696810|Wikipedia:RNase_P|EC:3.1.26.5|MetaCyc:3.1.26.5-RXN molecular_function owl:Class
GO:0035715 biolink:NamedThing chemokine (C-C motif) ligand 2 binding Binding to chemokine (C-C motif) ligand 2. got7fsn_ti CCL2 binding bf 2011-03-03T04:24:24Z molecular_function owl:Class
GO:0008854 biolink:NamedThing exodeoxyribonuclease V activity Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. got7fsn_ti E. coli exonuclease V activity|exonuclease V activity|E. coli exonuclease V|RecBC deoxyribonuclease activity|gene recBC endoenzyme|gene recBCD enzymes|Escherichia coli exonuclease V|gene recBC DNase activity EC:3.1.11.5|MetaCyc:3.1.11.5-RXN molecular_function owl:Class
GO:0106212 biolink:NamedThing centromere detachment from spindle pole body involved in meiotic chromosome organization The cell cycle process in which centromeres dissociate from the spindle pole body, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I. got7fsn_ti centromere detachment from spindle pole body involved in chromosome organization involved in meiotic cell cycle|centromere detachment from SPB involved in meiotic chromosome organization hjd 2019-06-25T18:28:39Z biological_process owl:Class
GO:0097128 biolink:NamedThing cyclin D1-CDK4 complex A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:48:36Z cellular_component owl:Class
GO:0043641 biolink:NamedThing novobiocin metabolic process The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase. got7fsn_ti novobiocin metabolism Wikipedia:Novobiocin biological_process owl:Class
GO:0050200 biolink:NamedThing plasmalogen synthase activity Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine. got7fsn_ti O-1-alkenylglycero-3-phosphorylcholine acyltransferase activity|lysoplasmenylcholine acyltransferase activity|1-alkenyl-glycero-3-phosphorylcholine:acyl-CoA acyltransferase activity|acyl-CoA:1-O-alk-1-enyl-glycero-3-phosphocholine 2-O-acyltransferase activity EC:2.3.1.25|MetaCyc:PLASMALOGEN-SYNTHASE-RXN molecular_function owl:Class
GO:1990430 biolink:NamedThing extracellular matrix protein binding Binding to a protein that is part of an extracellular matrix. got7fsn_ti jl 2014-07-29T14:57:07Z molecular_function owl:Class
GO:1901771 biolink:NamedThing daunorubicin biosynthetic process The chemical reactions and pathways resulting in the formation of daunorubicin. got7fsn_ti daunorubicin formation|daunorubicin anabolism|daunorubicin biosynthesis|daunorubicin synthesis yaf 2013-01-15T10:14:33Z biological_process owl:Class
GO:0044597 biolink:NamedThing daunorubicin metabolic process The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. got7fsn_ti jl 2012-05-01T03:09:51Z biological_process owl:Class
GO:0014051 biolink:NamedThing gamma-aminobutyric acid secretion The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues. got7fsn_ti GABA secretion biological_process owl:Class
GO:0018264 biolink:NamedThing isopeptide cross-linking via N-(L-isoaspartyl)-glycine The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine. got7fsn_ti RESID:AA0126 biological_process owl:Class
GO:0031688 biolink:NamedThing A2B adenosine receptor binding Binding to an A2B adenosine receptor. got7fsn_ti A2B adenosine receptor ligand molecular_function owl:Class
GO:0075025 biolink:NamedThing initiation of appressorium formation The process in which a relatively unspecialized cell starts to acquire specialized features of the symbiont appressorium to aid in infection of the host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti appressorium initiation on or near host|initiation of symbiont appressorium on or near host|initiation of appressorium by symbiont on or near host|initiation of appressorium on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0001165 biolink:NamedThing RNA polymerase I cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase I. RNA polymerase I elements are referred to either enhancers or upstream control element (UCE, or alternately referred to as the upstream element). got7fsn_ti RNA polymerase I upstream control element sequence-specific DNA binding|RNA polymerase I upstream element sequence-specific DNA binding|RNA polymerase I enhancer sequence-specific DNA binding krc 2011-01-31T05:29:59Z GO:0001166 molecular_function owl:Class
GO:0002570 biolink:NamedThing somatic diversification of immunoglobulin genes by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions. got7fsn_ti somatic diversification of antibody genes by N region addition biological_process owl:Class
GO:0035822 biolink:NamedThing gene conversion A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor. The resulting acceptor sequence is identical to that of the donor. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18777 bf 2011-05-04T01:04:39Z biological_process owl:Class
GO:0047638 biolink:NamedThing albendazole monooxygenase activity Catalysis of the reaction: albendazole + H(+) + NADPH + O(2) = albendazole S-oxide + H(2)O + NADP(+). got7fsn_ti albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)|albendazole sulfoxidase activity|albendazole oxidase activity MetaCyc:ALBENDAZOLE-MONOOXYGENASE-RXN|KEGG_REACTION:R03712|RHEA:10796|EC:1.14.13.32 molecular_function owl:Class
GO:2001155 biolink:NamedThing negative regulation of glycolytic fermentation to ethanol Any process that stops, prevents or reduces the frequency, rate or extent of glucose catabolic process to ethanol. got7fsn_ti negative regulation of glucose fermentation to ethanol|negative regulation of ethanol fermentation mcc 2011-10-27T02:39:05Z biological_process owl:Class
GO:0047940 biolink:NamedThing glucuronokinase activity Catalysis of the reaction: D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + 2 H(+). got7fsn_ti glucurono-glucuronokinase activity|ATP:D-glucuronate 1-phosphotransferase activity|glucuronokinase (phosphorylating) EC:2.7.1.43|RHEA:17005|MetaCyc:GLUCURONOKINASE-RXN|KEGG_REACTION:R01476 molecular_function owl:Class
GO:0072667 biolink:NamedThing maintenance of protein location in vacuole Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere. got7fsn_ti mah 2011-02-14T02:56:57Z biological_process owl:Class
GO:0060114 biolink:NamedThing vestibular receptor cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a vestibular hair cell. got7fsn_ti vestibular hair cell differentiation biological_process owl:Class
GO:0006957 biolink:NamedThing complement activation, alternative pathway Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. got7fsn_ti complement cascade, alternative pathway biological_process owl:Class
GO:0070459 biolink:NamedThing prolactin secretion The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary. got7fsn_ti biological_process owl:Class
GO:0061459 biolink:NamedThing L-arginine transmembrane transporter activity Enables the stereospecific transfer of L-arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane. got7fsn_ti ATP-dependent L-arginine transmembrane transporter activity|arginine-importing ATPase activity|arginine porter activity|ATPase-coupled L-arginine transmembrane transporter activity|L-arginine-importing ATPase activity dph 2012-09-25T08:37:29Z GO:0015598|GO:0102022 molecular_function owl:Class
GO:0048645 biolink:NamedThing animal organ formation The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ. got7fsn_ti animal organ primordium initiation|initiation of an animal organ primordium biological_process owl:Class
GO:0044775 biolink:NamedThing DNA polymerase III, beta sliding clamp processivity factor complex A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species. got7fsn_ti jl 2013-03-13T13:59:48Z cellular_component owl:Class
GO:0045333 biolink:NamedThing cellular respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration). got7fsn_ti oxidative metabolism|oxidative metabolic process|respiration Wikipedia:Cellular_respiration biological_process owl:Class
GO:0015980 biolink:NamedThing energy derivation by oxidation of organic compounds The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released. got7fsn_ti chemoorganotrophy biological_process owl:Class
GO:0061126 biolink:NamedThing positive regulation of positive chemotaxis to cAMP by DIF-1 Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone. got7fsn_ti dph 2010-05-17T08:41:04Z biological_process owl:Class
GO:0019961 biolink:NamedThing interferon binding Binding to an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent. got7fsn_ti IFN binding molecular_function owl:Class
GO:0102647 biolink:NamedThing D-ribose 5-phosphate:D-sedoheptulose 7-phosphate transaldolase activity Catalysis of the reaction: sedoheptulose 7-phosphate + D-ribose 5-phosphate <=> D-glycero-D-altro-octulose 8-phosphate + D-erythrose 4-phosphate. got7fsn_ti MetaCyc:RXN-15789 molecular_function owl:Class
GO:0016087 biolink:NamedThing ecdysiostatic hormone activity The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion. got7fsn_ti molecular_function owl:Class
GO:0045057 biolink:NamedThing cisternal progression The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna. got7fsn_ti cisternal maturation biological_process owl:Class
GO:0007039 biolink:NamedThing protein catabolic process in the vacuole The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases. got7fsn_ti vacuolar protein catabolism|vacuolar protein degradation|vacuolar protein catabolic process|vacuolar protein breakdown biological_process owl:Class
GO:0046661 biolink:NamedThing male sex differentiation The establishment of the sex of a male organism by physical differentiation. got7fsn_ti biological_process owl:Class
GO:0019779 biolink:NamedThing Atg8 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti APG8 activating enzyme activity|APG7 molecular_function owl:Class
GO:0000428 biolink:NamedThing DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity. got7fsn_ti cellular_component owl:Class
GO:0030880 biolink:NamedThing RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. got7fsn_ti multisubunit RNA polymerase cellular_component owl:Class
GO:0009232 biolink:NamedThing riboflavin catabolic process The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). got7fsn_ti vitamin B2 catabolism|vitamin B2 catabolic process|riboflavin breakdown|vitamin G catabolism|vitamin G catabolic process|riboflavin catabolism|riboflavin degradation biological_process owl:Class
GO:0051558 biolink:NamedThing phlobaphene metabolic process The chemical reactions and pathways involving phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols. got7fsn_ti phlobaphene metabolism biological_process owl:Class
GO:0102598 biolink:NamedThing 3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity Catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin D + NADP + H2O. got7fsn_ti EC:1.14.14.123|RHEA:41472|MetaCyc:RXN-15382 molecular_function owl:Class
GO:0070250 biolink:NamedThing mating projection membrane The portion of the plasma membrane surrounding a mating projection, the projection formed by unicellular fungi in response to mating pheromone. got7fsn_ti shmoo membrane cellular_component owl:Class
GO:0086015 biolink:NamedThing SA node cell action potential An action potential that occurs in a sinoatrial node cardiac muscle cell. got7fsn_ti sinus node cardiac muscle cell action potential|sinoatrial node cardiac muscle cell action potential|SAN cardiac muscle cell action potential|SA node cardiac muscle cell action potential tb 2011-11-10T08:50:15Z biological_process owl:Class
GO:0086001 biolink:NamedThing cardiac muscle cell action potential An action potential that occurs in a cardiac muscle cell. got7fsn_ti tb 2011-11-10T07:45:11Z biological_process owl:Class
GO:0090546 biolink:NamedThing chlorophyll fluorescence The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is re-emitted as light. got7fsn_ti tb 2013-03-27T14:23:27Z biological_process owl:Class
GO:0015850 biolink:NamedThing organic hydroxy compound transport The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom. got7fsn_ti organic alcohol transport biological_process owl:Class
GO:0070516 biolink:NamedThing CAK-ERCC2 complex A protein complex formed by the association of the cyclin-dependent protein kinase activating kinase (CAK) holoenzyme complex with ERCC2. got7fsn_ti cyclin-dependent protein kinase activating kinase holoenzyme-ERCC2 complex cellular_component owl:Class
GO:0072225 biolink:NamedThing metanephric late distal convoluted tubule development The process whose specific outcome is the progression of the metanephric late distal convoluted tubule over time, from its formation to the mature structure. The metanephric late distal convoluted tubule contains metanephric DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive. got7fsn_ti mah 2010-03-18T03:37:04Z biological_process owl:Class
GO:0072068 biolink:NamedThing late distal convoluted tubule development The process whose specific outcome is the progression of the late distal convoluted tubule over time, from its formation to the mature structure. The late distal convoluted tubule contains DCT cells and intercalated (IC) alpha and beta cells and is vasopressin-sensitive. got7fsn_ti mah 2010-01-25T04:15:50Z biological_process owl:Class
GO:0097149 biolink:NamedThing centralspindlin complex A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals). got7fsn_ti pr 2011-08-04T11:15:37Z cellular_component owl:Class
GO:0033242 biolink:NamedThing negative regulation of cellular amine catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines. got7fsn_ti negative regulation of amine catabolism|negative regulation of amine breakdown|negative regulation of amine degradation biological_process owl:Class
GO:0032133 biolink:NamedThing chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin. got7fsn_ti CPC complex|CPC|chromosomal passenger complex cellular_component owl:Class
GO:0047541 biolink:NamedThing 2-furoate-CoA ligase activity Catalysis of the reaction: 2-furoate + ATP + CoA = 2-furoyl-CoA + AMP + diphosphate + H(+). got7fsn_ti 2-furoyl coenzyme A synthetase activity|2-furoate:CoA ligase (AMP-forming) EC:6.2.1.31|MetaCyc:2-FUROATE--COA-LIGASE-RXN|KEGG_REACTION:R02986|RHEA:19269 molecular_function owl:Class
GO:1990238 biolink:NamedThing double-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within a double-stranded deoxyribonucleic acid molecule by creating internal breaks. got7fsn_ti dsDNA-specific endodeoxyribonuclease activity pg 2013-11-15T00:59:42Z molecular_function owl:Class
GO:0043712 biolink:NamedThing 2-hydroxyisocaproate CoA-transferase activity Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate. got7fsn_ti (R)-2-hydroxyisocaproate CoA-transferase activity|(R)-2-hydroxyisocaproate CoA transferase activity molecular_function owl:Class
GO:0052691 biolink:NamedThing UDP-arabinopyranose mutase activity Catalysis of the reaction: UDP-beta-L-arabinofuranose = UDP-beta-L-arabinopyranose. got7fsn_ti UDP-L-arabinose mutase activity|UDP-L-arabinopyranose furanomutase activity|UDP-L-Ara mutase activity|uridine-diphosphate-L-arabinose mutase activity|UDP-arabinopyranose pyranomutase activity EC:5.4.99.30|MetaCyc:RXN-11552|RHEA:28350 molecular_function owl:Class
GO:0021755 biolink:NamedThing eurydendroid cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts. got7fsn_ti biological_process owl:Class
GO:0071251 biolink:NamedThing cellular response to silicon dioxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silicon dioxide stimulus. got7fsn_ti cellular response to silica|cellular response to silox mah 2009-12-03T03:09:41Z biological_process owl:Class
GO:0061909 biolink:NamedThing autophagosome-lysosome fusion The process in which autophagosomes, double-membraned vesicles containing cytoplasmic material, fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the autophagosome. got7fsn_ti autophagosome fusion|autophagosome-vacuole fusion dph 2017-06-29T17:07:52Z biological_process owl:Class
GO:0090646 biolink:NamedThing mitochondrial tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion. got7fsn_ti tb 2015-06-12T15:57:13Z biological_process owl:Class
GO:0097646 biolink:NamedThing calcitonin family receptor signaling pathway A series of molecular signals initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) combining with a calcitonin family receptor on the surface of the target cell. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far. got7fsn_ti calcitonin family receptor signalling pathway pr 2014-09-09T17:48:05Z biological_process owl:Class
GO:0035152 biolink:NamedThing regulation of tube architecture, open tracheal system Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network. got7fsn_ti regulation of tracheal tube architecture biological_process owl:Class
GO:0071666 biolink:NamedThing Slit-Robo signaling complex A protein-carbohydrate complex that consists of a transmembrane roundabout (Robo) receptor, an extracellular Slit ligand and heparin/heparan sulfate. got7fsn_ti Slit-Robo signalling complex mah 2010-02-12T03:35:28Z cellular_component owl:Class
GO:0032992 biolink:NamedThing protein-carbohydrate complex A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other. got7fsn_ti Macromolecular complexes in which the carbohydrate component is all covalently bound to protein are not considered protein carbohydrate complexes. cellular_component owl:Class
GO:0034908 biolink:NamedThing 2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+. got7fsn_ti UM-BBD_reactionID:r0724|EC:1.14.12.- molecular_function owl:Class
GO:0046911 biolink:NamedThing metal chelating activity The formation of bonds from two or more atoms within the same ligand to a metal atom in complexes in which the metal is part of a ring. got7fsn_ti metal chelation|heavy metal chelation molecular_function owl:Class
GO:0046872 biolink:NamedThing metal ion binding Binding to a metal ion. got7fsn_ti metal binding|heavy metal binding molecular_function owl:Class
GO:1990579 biolink:NamedThing peptidyl-serine trans-autophosphorylation The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer. got7fsn_ti serine transautophosphorylation|serine autophosphorylation in trans bf 2014-12-09T09:20:08Z biological_process owl:Class
GO:0036290 biolink:NamedThing protein trans-autophosphorylation The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer. got7fsn_ti trans-autophosphorylation bf 2012-07-18T10:27:06Z biological_process owl:Class
GO:0090077 biolink:NamedThing foam cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. got7fsn_ti tb 2009-09-15T03:46:30Z biological_process owl:Class
GO:0102421 biolink:NamedThing curcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity Catalysis of the reaction: curcumin 4'-O-beta-D-gentiobioside + UDP-alpha-D-glucose <=> curcumin 4'-O-beta-D-gentiotrioside + UDP + H+. got7fsn_ti MetaCyc:RXN-13813 molecular_function owl:Class
GO:0045862 biolink:NamedThing positive regulation of proteolysis Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. got7fsn_ti up-regulation of proteolysis|positive regulation of peptidolysis|upregulation of proteolysis|activation of proteolysis|stimulation of proteolysis|up regulation of proteolysis biological_process owl:Class
GO:0032270 biolink:NamedThing positive regulation of cellular protein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. got7fsn_ti positive regulation of cellular protein metabolism|up-regulation of cellular protein metabolic process|stimulation of cellular protein metabolic process|upregulation of cellular protein metabolic process|activation of cellular protein metabolic process|up regulation of cellular protein metabolic process biological_process owl:Class
GO:0060235 biolink:NamedThing lens induction in camera-type eye Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens. got7fsn_ti biological_process owl:Class
GO:0035845 biolink:NamedThing photoreceptor cell outer segment organization A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials. got7fsn_ti photoreceptor outer segment organization|photoreceptor cell outer segment organisation bf 2011-05-10T10:44:09Z biological_process owl:Class
GO:0018479 biolink:NamedThing benzaldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+. got7fsn_ti benzaldehyde (NAD) dehydrogenase activity|benzaldehyde:NAD+ oxidoreductase activity EC:1.2.1.28|MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN|RHEA:11840|UM-BBD_reactionID:r0269 molecular_function owl:Class
GO:0047082 biolink:NamedThing 3,9-dihydroxypterocarpan 6a-monooxygenase activity Catalysis of the reaction: (6aR,11aR)-3,9-dihydroxypterocarpan + H(+) + NADPH + O(2) = (6aS,11aS)-3,6a,9-trihydroxypterocarpan + H(2)O + NADP(+). (6aS,11aS)-3,6a,9-trihydroxypterocarpan is also known as (-)-glycinol. got7fsn_ti (6aR,11aR)-3,9-dihydroxypterocarpan,NADPH:oxygen oxidoreductase (6a-hydroxylating)|3,9-dihydroxypterocarpan 6alpha-monooxygenase|3,9-dihydroxypterocarpan 6a-hydroxylase activity RHEA:15321|MetaCyc:RXN-4505|KEGG_REACTION:R03452|EC:1.14.14.93 molecular_function owl:Class
GO:1905278 biolink:NamedThing positive regulation of epithelial tube formation Any process that activates or increases the frequency, rate or extent of epithelial tube formation. got7fsn_ti activation of epithelial tube formation|upregulation of epithelial tube formation|up-regulation of epithelial tube formation|up regulation of epithelial tube formation An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). bhm 2016-06-20T09:35:57Z biological_process owl:Class
GO:0051045 biolink:NamedThing negative regulation of membrane protein ectodomain proteolysis Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis. got7fsn_ti down regulation of membrane protein ectodomain proteolysis|downregulation of membrane protein ectodomain proteolysis|inhibition of membrane protein ectodomain proteolysis|down-regulation of membrane protein ectodomain proteolysis biological_process owl:Class
GO:0042177 biolink:NamedThing negative regulation of protein catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. got7fsn_ti negative regulation of protein catabolism|negative regulation of protein breakdown|down regulation of protein catabolic process|inhibition of protein catabolic process|downregulation of protein catabolic process|negative regulation of protein degradation|down-regulation of protein catabolic process biological_process owl:Class
GO:0045039 biolink:NamedThing protein insertion into mitochondrial inner membrane The processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane. got7fsn_ti mitochondrial inner membrane protein import|protein transport into mitochondrial inner membrane|protein import into mitochondrial inner membrane https://github.com/geneontology/go-ontology/issues/15800 biological_process owl:Class
GO:0015044 biolink:NamedThing rubredoxin-NAD+ reductase activity Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+. got7fsn_ti DPNH-rubredoxin reductase activity|NADH:rubredoxin oxidoreductase activity|dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity|NADH--rubredoxin oxidoreductase activity|rubredoxin--NAD reductase activity|NADH--rubredoxin reductase activity|rubredoxin--nicotinamide adenine dinucleotide reductase activity|rubredoxin:NAD+ oxidoreductase activity|reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity|NADH:rubredoxin reductase activity EC:1.18.1.1|MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN|RHEA:18597 molecular_function owl:Class
GO:0015045 biolink:NamedThing rubredoxin-NAD(P)+ reductase activity Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+. got7fsn_ti rubredoxin--nicotinamide adenine activity|NAD(P)H--rubredoxin oxidoreductase activity|dinucleotide phosphate reductase activity|rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity|NADPH:rubredoxin reductase activity|rubredoxin:NAD(P)+ oxidoreductase activity|NAD(P)--rubredoxin oxidoreductase activity MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN|EC:1.18.1.4 molecular_function owl:Class
GO:0022004 biolink:NamedThing midbrain-hindbrain boundary maturation during brain development A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. got7fsn_ti biological_process owl:Class
GO:0060790 biolink:NamedThing tooth placode formation The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud. got7fsn_ti dph 2009-08-04T12:21:47Z biological_process owl:Class
GO:0006599 biolink:NamedThing phosphagen metabolic process The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. got7fsn_ti phosphagen metabolism biological_process owl:Class
GO:0060787 biolink:NamedThing positive regulation of posterior neural plate formation by fibroblast growth factor receptor signaling pathway Any process that increases the rate or extent of the formation of the posterior neural plate, the posterior end of the flat, thickened layer of ectodermal cells known as the neural plate. got7fsn_ti positive regulation of posterior neural plate formation by FGF receptor signaling pathway|positive regulation of posterior neural plate formation by fibroblast growth factor receptor signalling pathway dph 2009-08-04T09:48:31Z biological_process owl:Class
GO:0008543 biolink:NamedThing fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. got7fsn_ti FGF receptor signaling pathway|fibroblast growth factor receptor signalling pathway|FGF receptor signalling pathway|FGFR signaling pathway biological_process owl:Class
GO:0039502 biolink:NamedThing suppression by virus of host type I interferon-mediated signaling pathway Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti inhibition of host interferon signaling pathway by virus|suppression by virus of host type I interferon-mediated signalling pathway|negative regulation by virus of host type I interferon-mediated signaling pathway|suppression by virus of host type I IFN-mediated signaling pathway bf 2011-05-11T04:06:28Z VZ:883 biological_process owl:Class
GO:0033871 biolink:NamedThing [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate; modifies selected glucosamine residues preceded by GlcA2S. got7fsn_ti glucosaminyl 3-O-sulfotransferase 2 activity|heparin-glucosamine 3-sulfotransferase 2 activity|isoform/isozyme 2 (3-OST-2, HS3ST2)|heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity|3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase activity|glucosaminyl 3-O-sulfotransferase activity|3-OST-2|heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 activity MetaCyc:2.8.2.29-RXN|EC:2.8.2.29 molecular_function owl:Class
GO:0038120 biolink:NamedThing CCL21-activated CCR7 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CCL21-activated CCR7 signalling pathway bf 2012-03-22T11:47:24Z biological_process owl:Class
GO:0048716 biolink:NamedThing labrum morphogenesis The process in which the anatomical structures of labrum are generated and organized. got7fsn_ti biological_process owl:Class
GO:0097178 biolink:NamedThing ruffle assembly The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42. got7fsn_ti membrane ruffle formation|membrane ruffling pr 2011-10-16T01:46:09Z biological_process owl:Class
GO:0031529 biolink:NamedThing ruffle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell. got7fsn_ti ruffle organization and biogenesis|ruffle organisation biological_process owl:Class
GO:0047900 biolink:NamedThing formate kinase activity Catalysis of the reaction: ATP + formate = ADP + formyl phosphate + H(+). got7fsn_ti ATP:formate phosphotransferase activity KEGG_REACTION:R00518|EC:2.7.2.6|MetaCyc:FORMATE-KINASE-RXN|RHEA:16009 molecular_function owl:Class
GO:0018429 biolink:NamedThing copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide. got7fsn_ti copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide RESID:AA0298 biological_process owl:Class
GO:0102291 biolink:NamedThing 11alpha-hydroxy-beta-amyrin dehydrogenase activity Catalysis of the reaction: 11alpha-hydroxy-beta-amyrin + O2 + NADPH + H+ = 11-oxo-beta-amyrin + 2 H2O + NADP. got7fsn_ti EC:1.14.14.152|MetaCyc:RXN-12682|RHEA:31719 molecular_function owl:Class
GO:0061759 biolink:NamedThing alpha-ketoglutarate reductase activity Catalysis of the reaction: 2-oxoglutarate + reduced acceptor = (S)-2-hydroxyglutarate + acceptor. got7fsn_ti D-2HG reductase activity|2-hydroxyglutarate dehydrogenase activity, reverse reaction|2-ketoglutarate reductase activity|2-oxoglutarate reductase activity dph 2016-03-07T08:38:57Z RHEA:21254 molecular_function owl:Class
GO:0051562 biolink:NamedThing negative regulation of mitochondrial calcium ion concentration Any process that decreases the concentration of calcium ions in mitochondria. got7fsn_ti reduction of calcium ion concentration in mitochondria|reduction of calcium ion concentration in mitochondrion|mitochondrial calcium ion concentration reduction|reduction of mitochondrial calcium ion concentration biological_process owl:Class
GO:0051560 biolink:NamedThing mitochondrial calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings. got7fsn_ti mitochondrial calcium ion concentration regulation|calcium ion homeostasis in mitochondria|regulation of mitochondrial calcium ion concentration|regulation of calcium ion concentration in mitochondria|calcium ion homeostasis in mitochondrion|regulation of calcium ion concentration in mitochondrion biological_process owl:Class
GO:1990444 biolink:NamedThing F-box domain binding Binding to an F-box domain of a protein. got7fsn_ti bf 2014-08-05T13:45:14Z molecular_function owl:Class
GO:0002412 biolink:NamedThing antigen transcytosis by M cells in mucosal-associated lymphoid tissue The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT. got7fsn_ti antigen transport by M cells in MALT|antigen transcytosis by M cells in MALT|antigen transport by M cells in mucosal-associated lymphoid tissue biological_process owl:Class
GO:0140488 biolink:NamedThing heme receptor activity Binding specifically to heme to deliver it to a transport vesicle. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19699 pg 2020-06-29T14:16:16Z molecular_function owl:Class
GO:0031140 biolink:NamedThing induction of conjugation upon nutrient starvation The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients. got7fsn_ti biological_process owl:Class
GO:1900566 biolink:NamedThing chanoclavine-I biosynthetic process The chemical reactions and pathways resulting in the formation of chanoclavine-I. got7fsn_ti chanoclavine-I formation|chanoclavine-I biosynthesis|chanoclavine-I synthesis|chanoclavine-I anabolism di 2012-05-15T06:30:55Z biological_process owl:Class
GO:0047731 biolink:NamedThing catechol oxidase (dimerizing) activity Catalysis of the reaction: 4 catechol + 3 O2 = 2 dibenzo[1,4]dioxin-2,3-dione + 6 H2O. got7fsn_ti catechol:oxygen oxidoreductase (dimerizing) EC:1.1.3.14|MetaCyc:CATECHOL-OXIDASE-DIMERIZING-RXN|RHEA:12809 molecular_function owl:Class
GO:0070457 biolink:NamedThing D-galactose-1-phosphate phosphatase activity Catalysis of the reaction: D-galactose-1-phosphate + H2O = D-galactose + phosphate. got7fsn_ti molecular_function owl:Class
GO:0072111 biolink:NamedThing cell proliferation involved in kidney development The multiplication or reproduction of cells, resulting in the expansion of the population in the kidney. got7fsn_ti mah 2010-02-22T10:48:45Z biological_process owl:Class
GO:0020033 biolink:NamedThing antigenic variation Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system. got7fsn_ti surface antigen variation https://github.com/geneontology/go-ontology/issues/18357 GO:0020034 Wikipedia:Antigenic_variation biological_process owl:Class
GO:0023030 biolink:NamedThing MHC class Ib protein binding, via antigen binding groove Binding to a major histocompatibility complex class Ib molecules via the antigen binding groove. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0023029 biolink:NamedThing MHC class Ib protein binding Binding to a major histocompatibility complex class Ib molecules. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0031119 biolink:NamedThing tRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. got7fsn_ti biological_process owl:Class
GO:0030430 biolink:NamedThing host cell cytoplasm The cytoplasm of a host cell. got7fsn_ti other organism cytoplasm pr 2014-12-01T14:14:21Z GO:0097679 cellular_component owl:Class
GO:0033853 biolink:NamedThing aspartate-prephenate aminotransferase activity Catalysis of the reaction: L-arogenate + oxaloacetate = prephenate + L-aspartate. got7fsn_ti L-aspartate:prephenate aminotransferase activity|L-arogenate:oxaloacetate aminotransferase activity|PAT|prephenate aspartate aminotransferase activity|prephenate transaminase activity RHEA:20445|MetaCyc:PREPHENATE-ASP-TRANSAMINE-RXN|EC:2.6.1.78 molecular_function owl:Class
GO:0047328 biolink:NamedThing acyl-phosphate-hexose phosphotransferase activity Catalysis of the reaction: D-hexose + acyl phosphate = D-hexose phosphate + an acid. got7fsn_ti acyl-phosphate:D-hexose phosphotransferase activity|hexose phosphate:hexose phosphotransferase activity MetaCyc:2.7.1.61-RXN|RHEA:13077|EC:2.7.1.61 molecular_function owl:Class
GO:0034212 biolink:NamedThing peptide N-acetyltransferase activity Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. got7fsn_ti Reactome:R-HSA-3371554 molecular_function owl:Class
GO:0033964 biolink:NamedThing glycosphingolipid deacylase activity Catalysis of the hydrolysis of gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives. got7fsn_ti glycosphingolipid ceramide deacylase activity|glycosphingolipid amidohydrolase activity EC:3.5.1.69|MetaCyc:3.5.1.69-RXN molecular_function owl:Class
GO:0047901 biolink:NamedThing formyl-CoA hydrolase activity Catalysis of the reaction: formyl-CoA + H(2)O = CoA + formate + H(+). got7fsn_ti formyl coenzyme A hydrolase activity KEGG_REACTION:R00521|RHEA:19741|EC:3.1.2.10|MetaCyc:FORMYL-COA-HYDROLASE-RXN molecular_function owl:Class
GO:0048679 biolink:NamedThing regulation of axon regeneration Any process that modulates the frequency, rate or extent of axon regeneration. got7fsn_ti biological_process owl:Class
GO:0090642 biolink:NamedThing microsporidian-type exospore The dense, protein rich outermost layer of a microsporidian spore wall that lies above the endospore. got7fsn_ti tb 2015-05-04T14:17:06Z cellular_component owl:Class
GO:0018070 biolink:NamedThing peptidyl-serine phosphopantetheinylation The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine. got7fsn_ti RESID:AA0150 biological_process owl:Class
GO:0008542 biolink:NamedThing visual learning Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue. got7fsn_ti spatial learning biological_process owl:Class
GO:0008974 biolink:NamedThing phosphoribulokinase activity Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+). got7fsn_ti 5-phosphoribulose kinase activity|PRuK|ribulose phosphate kinase activity|PRK|PKK|phosphoribulokinase (phosphorylating)|ATP:D-ribulose-5-phosphate 1-phosphotransferase activity|phosphopentokinase activity|ribulose-5-phosphate kinase activity MetaCyc:PHOSPHORIBULOKINASE-RXN|EC:2.7.1.19|RHEA:19365|KEGG_REACTION:R01523 molecular_function owl:Class
GO:0001614 biolink:NamedThing purinergic nucleotide receptor activity Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti P2 receptor|purinoceptor|purinoreceptor|purinergic receptor activity bf 2010-10-22T10:57:12Z GO:0035586 molecular_function owl:Class
GO:1990360 biolink:NamedThing PKM2 protein kinase complex A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer. got7fsn_ti PKM2-SAICAR protein kinase complex|PKM2-SAICAR complex bhm 2014-04-17T14:03:36Z cellular_component owl:Class
GO:1902911 biolink:NamedThing protein kinase complex A protein complex which is capable of protein kinase activity. got7fsn_ti An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). bhm 2014-04-17T13:52:40Z cellular_component owl:Class
GO:0009556 biolink:NamedThing microsporogenesis The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores. got7fsn_ti microspore development biological_process owl:Class
GO:0051979 biolink:NamedThing alginic acid acetylation The addition of O-acetyl ester groups to alginic acid, a linear polymer of D-mannuronate and L-guluronate. got7fsn_ti alginate acetylation biological_process owl:Class
GO:0042120 biolink:NamedThing alginic acid metabolic process The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). got7fsn_ti alginic acid metabolism|alginate metabolism|alginate metabolic process biological_process owl:Class
GO:0048011 biolink:NamedThing neurotrophin TRK receptor signaling pathway A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti TrkB signaling pathway|TrkC signaling pathway|tropomyosin-receptor-kinase signaling|TrkA signaling pathway biological_process owl:Class
GO:0140018 biolink:NamedThing regulation of cytoplasmic translational fidelity Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code. got7fsn_ti pg 2017-04-06T12:27:10Z biological_process owl:Class
GO:0006450 biolink:NamedThing regulation of translational fidelity Any process that modulates the ability of the translational apparatus to interpret the genetic code. got7fsn_ti regulation of translational accuracy GO:0000029 biological_process owl:Class
GO:0106106 biolink:NamedThing cold-induced thermogenesis The process by which heat is generated by increasing metabolism in response to cold ambient temperatures in order to maintain a stable core body temperature. got7fsn_ti CIT hjd 2018-03-21T20:30:52Z biological_process owl:Class
GO:0045138 biolink:NamedThing nematode male tail tip morphogenesis The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome. got7fsn_ti male tail morphogenesis|male tail tip morphogenesis|tail tip morphogenesis biological_process owl:Class
GO:0008718 biolink:NamedThing D-amino-acid dehydrogenase activity Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. got7fsn_ti D-amino-acid:acceptor oxidoreductase (deaminating)|D-amino-acid:(acceptor) oxidoreductase (deaminating) MetaCyc:DAADEHYDROG-RXN|RHEA:18125 molecular_function owl:Class
GO:0030691 biolink:NamedThing Noc2p-Noc3p complex A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis. got7fsn_ti Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. cellular_component owl:Class
GO:0052373 biolink:NamedThing suppression of symbiont entry into host by host Any process in which an organism stops, prevents, or reduces the frequency, rate or extent to which it enters into a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti downregulation by organism of entry into other organism during symbiotic interaction|down regulation by organism of entry into other organism during symbiotic interaction|negative regulation by organism of entry into other organism involved in symbiotic interaction|down-regulation by organism of entry into other organism during symbiotic interaction|negative regulation by organism of entry into other organism during symbiotic interaction|inhibition by organism of entry into other organism during symbiotic interaction biological_process owl:Class
GO:0018504 biolink:NamedThing cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+. got7fsn_ti cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity|cis-benzene glycol dehydrogenase activity|cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity RHEA:15457|EC:1.3.1.19|MetaCyc:1.3.1.19-RXN|UM-BBD_enzymeID:e0060 molecular_function owl:Class
GO:0033537 biolink:NamedThing ajugose biosynthetic process using galactinol:raffinose galactosyltransferase The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactinol:raffinose galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of galactinol to the oligosaccharide. got7fsn_ti ajugose biosynthesis using galactinol:raffinose galactosyltransferase|ajugose formation using galactinol:raffinose galactosyltransferase|ajugose anabolism using galactinol:raffinose galactosyltransferase|ajugose synthesis using galactinol:raffinose galactosyltransferase MetaCyc:PWY-5342 biological_process owl:Class
GO:0033536 biolink:NamedThing ajugose biosynthetic process The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. got7fsn_ti ajugose synthesis|ajugose anabolism|ajugose formation|ajugose biosynthesis biological_process owl:Class
GO:0061128 biolink:NamedThing positive regulation of chemotaxis to cAMP by DIF-2 Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone. got7fsn_ti dph 2010-05-17T08:48:17Z biological_process owl:Class
GO:0061124 biolink:NamedThing positive regulation of positive chemotaxis to cAMP by chlorinated alkylphenone Any process that increases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of a chlorinated alkylphenone. An alkylphenone is an aromatic polyketide with methyl and chlorine substitutions. got7fsn_ti dph 2010-05-17T08:33:40Z biological_process owl:Class
GO:0010954 biolink:NamedThing positive regulation of protein processing Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage. got7fsn_ti positive regulation of protein maturation by peptide bond cleavage tb 2009-04-27T12:09:13Z biological_process owl:Class
GO:1903319 biolink:NamedThing positive regulation of protein maturation Any process that activates or increases the frequency, rate or extent of protein maturation. got7fsn_ti upregulation of protein maturation|activation of protein maturation|up regulation of protein maturation|up-regulation of protein maturation vw 2014-08-18T12:59:23Z biological_process owl:Class
GO:0008748 biolink:NamedThing N-ethylmaleimide reductase activity Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+. got7fsn_ti RHEA:35523|MetaCyc:RXN0-5101 molecular_function owl:Class
GO:0030536 biolink:NamedThing larval feeding behavior Feeding behavior in a larval (immature) organism. got7fsn_ti larval feeding behaviour See also the biological process term 'feeding behavior ; GO:0007631'. biological_process owl:Class
GO:0035093 biolink:NamedThing spermatogenesis, exchange of chromosomal proteins The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin. got7fsn_ti somatic histone exchange|somatic histone replacement biological_process owl:Class
GO:0071905 biolink:NamedThing protein N-linked glucosylation via asparagine A process of protein N-linked glycosylation via asparagine in which glucose is added to the N4 of asparagine, forming an (S)-2-amino-4-(D-glucopyranosyl)amino-4-oxobutanoic acid residue. got7fsn_ti protein amino acid N-linked glucosylation via asparagine mah 2010-09-15T03:54:25Z RESID:AA0421 biological_process owl:Class
GO:0008781 biolink:NamedThing N-acylneuraminate cytidylyltransferase activity Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate. got7fsn_ti CMP-NANA synthetase activity|cytidine monophosphosialic acid synthetase activity|CMP-NeuAc synthetase activity|CTP:N-acylneuraminate cytidylyltransferase activity|CMP-Neu5Ac synthetase activity|CMP-sialate synthetase activity|CMP-N-acetylneuraminic acid synthase activity|CMP-sialate synthase activity|CMP-sialate diphosphorylase activity|cytidine monophosphoacetylneuraminic synthetase activity|CMP-sialic acid synthetase activity|CMP-N-acetylneuraminate synthetase activity|acetylneuraminate cytidylyltransferase activity|cytidine monophosphosialate pyrophosphorylase activity|acylneuraminate cytidyltransferase activity|CMP-N-acetylneuraminate synthase activity|cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity|CMP-N-acetylneuraminic acid synthetase activity|CMP-sialate pyrophosphorylase activity|CMP-sialic synthetase activity|CMP-NeuNAc synthetase activity|cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity|cytidine monophosphosialate synthetase activity|cytidine 5'-monophosphosialic acid synthetase activity EC:2.7.7.43|MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN|Reactome:R-HSA-4084982|RHEA:11344 molecular_function owl:Class
GO:0047933 biolink:NamedThing glucose-1,6-bisphosphate synthase activity Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate + alpha-D-glucose 1-phosphate = 3-phospho-D-glycerate + alpha-D-glucose 1,6-bisphosphate + H(+). got7fsn_ti glucose-1,6-bisphosphate synthetase activity|glucose 1,6-diphosphate synthase activity|3-phospho-D-glyceroyl-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity|3-phospho-D-glyceroyl-phosphate:alpha-D-glucose-1-phosphate 6-phosphotransferase activity RHEA:16769|MetaCyc:GLUCOSE-16-BISPHOSPHATE-SYNTHASE-RXN|KEGG_REACTION:R01660|Reactome:R-HSA-8955760|EC:2.7.1.106 molecular_function owl:Class
GO:0070141 biolink:NamedThing response to UV-A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. got7fsn_ti response to UVA light stimulus|response to UVA radiation stimulus|response to UV-A radiation stimulus|response to UV-A light stimulus biological_process owl:Class
GO:0045728 biolink:NamedThing respiratory burst after phagocytosis A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity. got7fsn_ti metabolic burst after phagocytosis|oxidative burst after phagocytosis biological_process owl:Class
GO:0002679 biolink:NamedThing respiratory burst involved in defense response A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. got7fsn_ti biological_process owl:Class
GO:0110128 biolink:NamedThing phloem sucrose unloading The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues. got7fsn_ti kmv 2018-09-07T21:38:52Z biological_process owl:Class
GO:0015770 biolink:NamedThing sucrose transport The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside. got7fsn_ti biological_process owl:Class
GO:0046208 biolink:NamedThing spermine catabolic process The chemical reactions and pathways resulting in the breakdown of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. got7fsn_ti spermine breakdown|spermine degradation|spermine catabolism biological_process owl:Class
GO:0033274 biolink:NamedThing response to vitamin B2 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B2 stimulus. got7fsn_ti response to riboflavin biological_process owl:Class
GO:0033053 biolink:NamedThing D-glutamine metabolic process The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid. got7fsn_ti D-glutamine metabolism biological_process owl:Class
GO:0103079 biolink:NamedThing 2-(3'-methylthio)propylmalate synthase activity Catalysis of the reaction: 5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-(3-methylthiopropyl)malate + coenzyme A. got7fsn_ti RHEA:25605|MetaCyc:RXNQT-4163 molecular_function owl:Class
GO:0097429 biolink:NamedThing amino acid ligation activity by nonribosomal peptide synthase Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase. got7fsn_ti pr 2012-11-16T12:34:22Z molecular_function owl:Class
GO:0032982 biolink:NamedThing myosin filament A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament. got7fsn_ti thick filament|myosin thick filament cellular_component owl:Class
GO:0021809 biolink:NamedThing neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration. got7fsn_ti neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:0021807 biolink:NamedThing motogenic signaling initiating cell movement in cerebral cortex The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex. got7fsn_ti motogenic signalling initiating cell movement in the cerebral cortex biological_process owl:Class
GO:0008803 biolink:NamedThing bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+). got7fsn_ti diadenosine tetraphosphate hydrolase activity|diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity|Ap(4)A hydrolase activity|diadenosinetetraphosphatase (symmetrical) activity|diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity|diadenosine tetraphosphatase (symmetrical)|dinucleosidetetraphosphatase (symmetrical) activity|bis(5'-adenosyl) tetraphosphatase activity|diadenosine polyphosphate hydrolase activity|symmetrical diadenosine tetraphosphate hydrolase activity|diadenosine 5',5'''-P1,P4-tetraphosphatase activity|dinucleosidetetraphosphate (symmetrical)|adenosine tetraphosphate phosphodiesterase activity|1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity|Ap4A hydrolase activity|P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity KEGG_REACTION:R00125|RHEA:24252|MetaCyc:3.6.1.41-RXN|EC:3.6.1.41 molecular_function owl:Class
GO:0003175 biolink:NamedThing tricuspid valve development The progression of the tricuspid valve over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-08T11:18:12Z biological_process owl:Class
GO:0090507 biolink:NamedThing phenylethylamine metabolic process involved in synaptic transmission The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission. got7fsn_ti tb 2012-11-15T15:06:08Z biological_process owl:Class
GO:0006458 biolink:NamedThing 'de novo' protein folding The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure. got7fsn_ti nascent chain protein folding biological_process owl:Class
GO:0022006 biolink:NamedThing zona limitans intrathalamica formation The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon. got7fsn_ti zli biosynthesis|zli formation biological_process owl:Class
GO:0060280 biolink:NamedThing negative regulation of ovulation Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. got7fsn_ti biological_process owl:Class
GO:0102535 biolink:NamedThing ladanein 6-O-methyltransferase activity Catalysis of the reaction: ladanein + S-adenosyl-L-methionine <=> H+ + salvigenin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-14752 molecular_function owl:Class
GO:0140526 biolink:NamedThing double membrane vesicle viral factory assembly A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19943 pg 2020-09-29T08:26:51Z biological_process owl:Class
GO:0035870 biolink:NamedThing dITP diphosphatase activity Catalysis of the reaction: dITP + H2O = dIMP + diphosphate. got7fsn_ti dITP pyrophosphatase activity|2'-Deoxyinosine-5'-triphosphate pyrophosphohydrolase activity|deoxyinosine triphosphate pyrophosphatase activity bf 2011-05-26T11:32:26Z RHEA:28342|EC:3.6.1.66|MetaCyc:RXN0-1602|Reactome:R-HSA-2509838|KEGG_REACTION:R03531 molecular_function owl:Class
GO:0098801 biolink:NamedThing regulation of renal system process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system. got7fsn_ti biological_process owl:Class
GO:0047461 biolink:NamedThing (+)-delta-cadinene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (+)-delta-cadinene. got7fsn_ti D-cadinene synthase activity|2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-delta-cadinene-forming) RHEA:19525|EC:4.2.3.13|MetaCyc:4.6.1.11-RXN molecular_function owl:Class
GO:0033259 biolink:NamedThing plastid DNA replication The process in which new strands of DNA are synthesized in a plastid. got7fsn_ti replication of plastid DNA|plastid DNA synthesis biological_process owl:Class
GO:0047248 biolink:NamedThing nuatigenin 3-beta-glucosyltransferase activity Catalysis of the reaction: nuatigenin + UDP-D-glucose = H(+) + nuatigenin 3-beta-D-glucopyranoside + UDP. got7fsn_ti UDPglucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity|UDP-glucose:(20S,22S,25S)-22,25-epoxyfurost-5-ene-3beta,26-diol 3-O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-nuatigenin glucosyltransferase activity|nuatigenin 3beta-glucosyltransferase activity RHEA:19329|EC:2.4.1.192|KEGG_REACTION:R04577|MetaCyc:2.4.1.192-RXN molecular_function owl:Class
GO:0015375 biolink:NamedThing glycine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in). got7fsn_ti GO:0015656 Reactome:R-HSA-5660840|Reactome:R-HSA-444120 molecular_function owl:Class
GO:0072377 biolink:NamedThing blood coagulation, common pathway A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex. got7fsn_ti See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. mah 2010-11-22T03:01:12Z biological_process owl:Class
GO:0061417 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. got7fsn_ti dph 2012-01-23T01:02:10Z biological_process owl:Class
GO:0001788 biolink:NamedThing antibody-dependent cellular cytotoxicity Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. got7fsn_ti antibody dependent cell death|type VI hypersensitivity|antibody dependent cell killing|antibody-dependent cell killing|antibody-dependent cell death|ADCC Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity|Wikipedia:Antibody-dependent_cellular_cytotoxicity biological_process owl:Class
GO:0001794 biolink:NamedThing type IIa hypersensitivity An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell. got7fsn_ti Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity. biological_process owl:Class
GO:0051598 biolink:NamedThing meiotic recombination checkpoint signaling A signaling process that contributes to a meiotic recombination checkpoint, that acts during late prophase I (pachytene) and prevents segregation of homologous chromosomes until recombination is completed, ensuring proper distribution of the genetic material to the gametes. got7fsn_ti signal transduction involved in meiotic recombination checkpoint|meiotic recombination checkpoint|pachytene checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072462 biological_process owl:Class
GO:0033313 biolink:NamedThing meiotic cell cycle checkpoint signaling A signaling process that contributes to a meiotic cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a meiotic cell cycle until conditions are suitable for the cell to proceed to the next stage. got7fsn_ti meiotic cell cycle checkpoint|signal transduction involved in meiotic cell cycle checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072411 biological_process owl:Class
GO:0047942 biolink:NamedThing glutamate-ethylamine ligase activity Catalysis of the reaction: L-glutamate + ATP + ethylamine = N(5)-ethyl-L-glutamine + ADP + 2 H(+) + phosphate. got7fsn_ti L-glutamate:ethylamine ligase (ADP-forming)|N5-ethylglutamine synthetase activity|N5-ethyl-L-glutamine synthetase activity|theanine synthetase activity|N(5)-ethyl-L-glutamine synthetase activity RHEA:20525|KEGG_REACTION:R02929|EC:6.3.1.6|MetaCyc:GLUTAMATE--ETHYLAMINE-LIGASE-RXN molecular_function owl:Class
GO:0034434 biolink:NamedThing sterol esterification A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol). got7fsn_ti biological_process owl:Class
GO:0052040 biolink:NamedThing modulation by symbiont of host programmed cell death Any process in which an organism modulates the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host non-apoptotic programmed cell death|modulation of host PCD GO:0052152 biological_process owl:Class
GO:0102326 biolink:NamedThing 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-6-(2,3-dihydroxyphenyl)-hexa-2,4-dienoate + H2O <=> 2,3-dihydroxybenzoate + 2-oxopent-4-enoate + H+. got7fsn_ti MetaCyc:RXN-13171 molecular_function owl:Class
GO:0004120 biolink:NamedThing photoreceptor cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide. got7fsn_ti molecular_function owl:Class
GO:0031963 biolink:NamedThing cortisol receptor activity Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function. got7fsn_ti For cortisol receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'. molecular_function owl:Class
GO:0035566 biolink:NamedThing regulation of metanephros size Any process that modulates the size of a metanephric kidney. got7fsn_ti regulation of metanephric kidney size bf 2010-07-23T11:34:06Z biological_process owl:Class
GO:0047330 biolink:NamedThing polyphosphate-glucose phosphotransferase activity Catalysis of the reaction: beta-D-glucose + long chain polyphosphate = glucose-6-phosphate + long chain polyphosphate. got7fsn_ti polyphosphate-D-(+)-glucose-6-phosphotransferase activity|polyphosphate:D-glucose 6-phosphotransferase activity|polyphosphate glucokinase activity|polyphosphate-glucose 6-phosphotransferase activity MetaCyc:2.7.1.63-RXN|EC:2.7.1.63|RHEA:22036 molecular_function owl:Class
GO:0050214 biolink:NamedThing progesterone monooxygenase activity Catalysis of the reaction: AH(2) + O(2) + progesterone = A + H(2)O + testosterone acetate. got7fsn_ti progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating)|progesterone hydroxylase activity EC:1.14.99.4|MetaCyc:PROGESTERONE-MONOOXYGENASE-RXN|KEGG_REACTION:R02212|RHEA:11984 molecular_function owl:Class
GO:0005137 biolink:NamedThing interleukin-5 receptor binding Binding to an interleukin-5 receptor. got7fsn_ti interleukin-5 receptor ligand|IL-5 molecular_function owl:Class
GO:0043855 biolink:NamedThing cyclic nucleotide-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. got7fsn_ti cyclic nucleotide activated ion channel activity|cyclic nucleotide gated ion channel activity|cyclic nucleotide-activated ion channel activity molecular_function owl:Class
GO:0031484 biolink:NamedThing myosin XIV complex A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails. got7fsn_ti cellular_component owl:Class
GO:0097130 biolink:NamedThing cyclin D3-CDK4 complex A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:54:17Z cellular_component owl:Class
GO:0062155 biolink:NamedThing curli secretion complex A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms. got7fsn_ti dph 2019-09-20T14:05:13Z cellular_component owl:Class
GO:0097659 biolink:NamedThing nucleic acid-templated transcription The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA). got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. pr 2014-10-01T13:49:27Z biological_process owl:Class
GO:0002213 biolink:NamedThing defense response to insect A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism. got7fsn_ti physiological defense response to insect GO:0002214 biological_process owl:Class
GO:0051804 biolink:NamedThing positive regulation of cytolysis in other organism involved in symbiotic interaction Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti up-regulation of cytolysis of cells in other organism during symbiotic interaction|upregulation of cytolysis of cells in other organism during symbiotic interaction|stimulation of cytolysis of cells in other organism during symbiotic interaction|positive regulation of cytolysis of cells in other organism involved in symbiotic interaction|up regulation of cytolysis of cells in other organism during symbiotic interaction|positive regulation of cytolysis of cells in other organism during symbiotic interaction|activation of cytolysis of cells in other organism during symbiotic interaction biological_process owl:Class
GO:0102792 biolink:NamedThing sinapaldehyde:NAD(P)+ oxidoreductase activity Catalysis of the reaction: sinapoyl aldehyde + NADP + H2O <=> 2 H+ + trans-sinapate + NADPH. got7fsn_ti MetaCyc:RXN-8014 molecular_function owl:Class
GO:0031950 biolink:NamedThing negative regulation of glucocorticoid catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids. got7fsn_ti downregulation of glucocorticoid catabolic process|down regulation of glucocorticoid catabolic process|inhibition of glucocorticoid catabolic process|down-regulation of glucocorticoid catabolic process biological_process owl:Class
GO:0097007 biolink:NamedThing 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone. got7fsn_ti 4,8,12-trimethyl-1,3,7,11-tridecatetraene synthase activity|TMTT synthase activity pr 2011-03-16T04:37:20Z MetaCyc:RXN-8620|RHEA:13545 molecular_function owl:Class
GO:0102829 biolink:NamedThing ajugose synthase activity Catalysis of the reaction: 2 verbascose <=> ajugose + stachyose. got7fsn_ti MetaCyc:RXN-8285 molecular_function owl:Class
GO:0140546 biolink:NamedThing defense response to symbiont Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20261 pg 2020-11-11T17:19:06Z biological_process owl:Class
GO:0102759 biolink:NamedThing campestanol hydroxylase activity Catalysis of the reaction: H+ + campestanol + O2 + NADPH <=> 6-deoxycathasterone + H2O + NADP. got7fsn_ti MetaCyc:RXN-773 molecular_function owl:Class
GO:0102602 biolink:NamedThing cytochrome P450 dependent 16beta-hydroxy-beta-amyrin epoxidase activity Catalysis of the reaction: 16beta-hydroxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-15386 molecular_function owl:Class
GO:0008219 biolink:NamedThing cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). got7fsn_ti necrosis|accidental cell death This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. biological_process owl:Class
GO:0052018 biolink:NamedThing modulation by symbiont of RNA levels in host The alteration by an organism of the levels of RNA in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host RNA levels biological_process owl:Class
GO:0070675 biolink:NamedThing hypoxanthine oxidase activity Catalysis of the reaction: hypoxanthine + H2O + O2 = xanthine + H2O2. got7fsn_ti xanthine oxidoreductase activity|hypoxanthine-xanthine oxidase activity|hypoxanthine:O(2) oxidoreductase activity|hypoxanthine:O2 oxidoreductase activity|hypoxanthine:oxygen oxidoreductase activity|schardinger enzyme|Schardinger enzyme activity mah 2009-05-29T01:12:55Z molecular_function owl:Class
GO:0050680 biolink:NamedThing negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation. got7fsn_ti down-regulation of epithelial cell proliferation|downregulation of epithelial cell proliferation|inhibition of epithelial cell proliferation|down regulation of epithelial cell proliferation biological_process owl:Class
GO:0021893 biolink:NamedThing cerebral cortex GABAergic interneuron fate commitment The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex. got7fsn_ti biological_process owl:Class
GO:0071665 biolink:NamedThing gamma-catenin-TCF7L2 complex A protein complex that contains gamma-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription. got7fsn_ti plakoglobin-TCF4 complex|gamma-catenin-TCF4 complex mah 2010-02-12T03:23:08Z cellular_component owl:Class
GO:0060912 biolink:NamedThing cardiac cell fate specification The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. got7fsn_ti cardiocyte cell fate specification dph 2009-09-17T08:53:21Z biological_process owl:Class
GO:0044869 biolink:NamedThing negative regulation by host of viral exo-alpha-sialidase activity The process in which a host organism decreases viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. got7fsn_ti jl 2014-09-18T14:13:51Z biological_process owl:Class
GO:0044866 biolink:NamedThing modulation by host of viral exo-alpha-sialidase activity The process in which a host organism effects a change in viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein. got7fsn_ti jl 2014-09-18T11:28:18Z biological_process owl:Class
GO:0033988 biolink:NamedThing bile-acid 7alpha-dehydratase activity Catalysis of the reaction: 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oate = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + H(2)O. got7fsn_ti 7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase (12alpha-hydroxy-3-oxochola-4,6-dienoate-forming) activity|7alpha,12alpha-dihydroxy-3-oxochol-4-enoate hydro-lyase activity|BA7 alpha dehydratase activity EC:4.2.1.106|KEGG_REACTION:R07318|MetaCyc:4.2.1.106-RXN|RHEA:10436 molecular_function owl:Class
GO:0004446 biolink:NamedThing inositol-hexakisphosphate phosphatase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate. got7fsn_ti 1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity|MIPP activity|multiple inositol-polyphosphate phosphatase activity|inositol tetrakisphosphate phosphomonoesterase activity EC:3.1.3.62|MetaCyc:RXN-7920 molecular_function owl:Class
GO:0036529 biolink:NamedThing protein deglycation, glyoxal removal The removal of glyoxal from a glycated protein, to form glycolate and a deglycated protein. got7fsn_ti protein deglycation of glyoxal-glycated protein bf 2016-08-04T10:41:25Z biological_process owl:Class
GO:0046295 biolink:NamedThing glycolate biosynthetic process The chemical reactions and pathways resulting in the formation of glycolate, the anion of hydroxyethanoic acid (glycolic acid). got7fsn_ti glycolate synthesis|glycolate biosynthesis|glycolate anabolism|glycolate formation biological_process owl:Class
GO:0002350 biolink:NamedThing peripheral B cell positive selection Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors. got7fsn_ti peripheral B-cell positive selection|peripheral B-lymphocyte positive selection|peripheral B lymphocyte positive selection biological_process owl:Class
GO:0018232 biolink:NamedThing peptide cross-linking via S-(L-isoglutamyl)-L-cysteine The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link. got7fsn_ti RESID:AA0108 biological_process owl:Class
GO:0000915 biolink:NamedThing actomyosin contractile ring assembly The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis. got7fsn_ti cytokinesis, actomyosin contractile ring formation|constriction ring assembly|contractile ring assembly|cytokinesis, contractile ring assembly|cytokinesis, actomyosin ring biosynthesis|cytokinesis, actomyosin contractile ring assembly|cytokinesis, actomyosin ring formation GO:0045573 biological_process owl:Class
GO:0035439 biolink:NamedThing halimadienyl-diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate. got7fsn_ti halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)|halimadienyl diphosphate synthase activity bf 2010-04-09T02:59:35Z RHEA:25621|EC:5.5.1.16 molecular_function owl:Class
GO:0099048 biolink:NamedThing CRISPR-cas system An adaptive immune response of bacteria that serves to clear host cells of foreign DNA and RNA. It has three distinct stage: acquisition of foreign DNA by integration into CRISPR loci in the host chromosome, CRISPR RNA (crRNA) biogenesis, and target interference. CISPR stands for Clustered Regularly Interspaced Short Palindromic Repeat, which describes the nature of the loci. got7fsn_ti biological_process owl:Class
GO:1901925 biolink:NamedThing negative regulation of protein import into nucleus during spindle assembly checkpoint Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus, and that occurs as a response to the mitotic cell cycle spindle assembly checkpoint. In S. cerevisiae, this process involves inhibition of the karyopherin/importin Kap121p (also known as Pse1p), which acts as the specific nuclear import receptor for several proteins, including Glc7p. Glc7p functions in opposition to key spindle assembly checkpoint protein Aurora kinase (Ipl1p). got7fsn_ti Kap121p transport inhibitory pathway|negative regulation of protein import into nucleus during mitotic cell cycle spindle assembly checkpoint|KTIP pr 2013-02-17T20:55:16Z biological_process owl:Class
GO:0044018 biolink:NamedThing histone acetyltransferase activity (H3-K36 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K36 specific) molecular_function owl:Class
GO:0060457 biolink:NamedThing negative regulation of digestive system process Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class
GO:0003088 biolink:NamedThing positive regulation of the force of heart contraction by circulating epinephrine The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction. got7fsn_ti increased force of heart contraction by circulating adrenaline|increased force of heart contraction by epinephrine in the bloodstream|positive regulation of heart contraction by circulating epinephrine|positive regulation of heart contraction by circulating adrenaline biological_process owl:Class
GO:0008994 biolink:NamedThing rhamnulose-1-phosphate aldolase activity Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde. got7fsn_ti L-rhamnulose-phosphate aldolase activity|rhamnulose phosphate aldolase activity|L-rhamnulose-1-phosphate lactaldehyde-lyase activity|L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)|L-rhamnulose 1-phosphate aldolase activity MetaCyc:RHAMNULPALDOL-RXN|RHEA:19689|EC:4.1.2.19 molecular_function owl:Class
GO:0005151 biolink:NamedThing interleukin-1, type II receptor binding Binding to a Type II interleukin-1 receptor. got7fsn_ti interleukin-1, type II receptor ligand|IL-1 type II molecular_function owl:Class
GO:0005149 biolink:NamedThing interleukin-1 receptor binding Binding to an interleukin-1 receptor. got7fsn_ti IL-1|interleukin-1 receptor ligand molecular_function owl:Class
GO:0002328 biolink:NamedThing pro-B cell differentiation The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed. got7fsn_ti pro-B lymphocyte differentiation|pro-B cell development biological_process owl:Class
GO:0002320 biolink:NamedThing lymphoid progenitor cell differentiation The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages. got7fsn_ti biological_process owl:Class
GO:0097240 biolink:NamedThing chromosome attachment to the nuclear envelope The process in which chromatin is anchored to the nuclear envelope. got7fsn_ti attachment of chromatin to nuclear envelope pr 2012-02-07T01:11:37Z biological_process owl:Class
GO:0050483 biolink:NamedThing IMP 5'-nucleotidase activity Catalysis of the reaction: 5'-IMP + H2O = inosine + phosphate. got7fsn_ti IMP-GMP specific 5'-nucleotidase activity|IMP 5' nucleotidase activity RHEA:27718|MetaCyc:RXN-7607 molecular_function owl:Class
GO:0032292 biolink:NamedThing peripheral nervous system axon ensheathment The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction. got7fsn_ti ensheathment of axons in peripheral nervous system biological_process owl:Class
GO:0046926 biolink:NamedThing peptide cross-linking via 2-(S-L-cysteinyl)-D-allo-threonine The post-translational cross-linking of a cysteine residue to an L-threonine residue to form 2-(S-L-cysteinyl)-D-allo-threonine. got7fsn_ti RESID:AA0342 biological_process owl:Class
GO:0048352 biolink:NamedThing paraxial mesoderm structural organization The process that contributes to the act of creating the structural organization of the paraxial mesoderm. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti paraxial mesoderm structural organisation biological_process owl:Class
GO:0008211 biolink:NamedThing glucocorticoid metabolic process The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. got7fsn_ti glucocorticosteroid metabolism|glucocorticosteroid metabolic process|glucocorticoid metabolism biological_process owl:Class
GO:0070584 biolink:NamedThing mitochondrion morphogenesis The process in which the anatomical structures of a mitochondrion are generated and organized. got7fsn_ti Note that this term is intended for annotation of gene products involved in mitochondrial shape changes associated with development; an example is the morphogenesis of the Nebenkern during spermatogenesis. mah 2009-04-24T10:54:19Z biological_process owl:Class
GO:0097062 biolink:NamedThing dendritic spine maintenance The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission. got7fsn_ti pr 2011-06-07T11:29:03Z biological_process owl:Class
GO:0036069 biolink:NamedThing light-dependent bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants. got7fsn_ti light-dependent bacteriochlorophyll formation|light-dependent bacteriochlorophyll anabolism|light-dependent bacteriochlorophyll synthesis|light dependent bacteriochlorophyll biosynthetic process|light-dependent bacteriochlorophyll biosynthesis bf 2011-12-15T04:45:16Z biological_process owl:Class
GO:0030494 biolink:NamedThing bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. got7fsn_ti bacteriochlorophyll biosynthesis|bacteriochlorophyll anabolism|bacteriochlorophyll formation|bacteriochlorophyll synthesis biological_process owl:Class
GO:0032603 biolink:NamedThing fractalkine production The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti fractalkine biosynthetic process|CX3CL1 production|neurotactin production|fractalkine metabolic process|ABCD-3 production https://github.com/geneontology/go-ontology/issues/19254 GO:0050754|GO:0050756|GO:0050751 biological_process owl:Class
GO:0018123 biolink:NamedThing peptidyl-cysteine ADP-ribosylation The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine. got7fsn_ti RESID:AA0169 biological_process owl:Class
GO:0034825 biolink:NamedThing tetralin ring-hydroxylating dioxygenase activity Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+. got7fsn_ti UM-BBD_reactionID:r1169|EC:1.14.12.- molecular_function owl:Class
GO:0047309 biolink:NamedThing dihydroxyphenylalanine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-dopa = 3,4-dihydroxyphenylpyruvate + L-glutamate. got7fsn_ti aspartate-DOPP transaminase (ADT)|3,4-dihydroxy-L-phenylalanine:2-oxoglutarate aminotransferase activity|DOPA aminotransferase activity|dopa transaminase activity|L-dopa transaminase activity|dihydroxyphenylalanine aminotransferase activity|phenylalanine-DOPP transaminase (PDT)|glutamate-DOPP transaminase (GDT) EC:2.6.1.49|RHEA:15273|MetaCyc:2.6.1.49-RXN|KEGG_REACTION:R02077 molecular_function owl:Class
GO:0097443 biolink:NamedThing sorting endosome A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles. got7fsn_ti MVB-tubule complex pr 2012-12-06T14:04:14Z NIF_Subcellular:sao1028571114 cellular_component owl:Class
GO:0140480 biolink:NamedThing mitotic spindle pole body insertion into the nuclear envelope A process in which the duplicated mitotic spindle pole body is inserted into a fenestra which opens in the nuclear envelope in early mitosis, and is subsequently tethered to the membrane. got7fsn_ti establishment of spindle pole body localisation in nuclear envelope|establishment of spindle pole body localization in nuclear envelope|establishment of spindle pole body localization to nuclear envelope https://github.com/geneontology/go-ontology/issues/14887 pg 2020-06-25T14:45:40Z biological_process owl:Class
GO:0070631 biolink:NamedThing spindle pole body localization Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells. got7fsn_ti spindle pole body localisation|maintenance of spindle pole body localization https://github.com/geneontology/go-ontology/issues/19149 mah 2009-05-06T02:21:38Z GO:0071790|GO:1990944 biological_process owl:Class
GO:0071076 biolink:NamedThing RNA 3' uridylation The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule. got7fsn_ti mah 2009-11-06T02:41:23Z biological_process owl:Class
GO:0004777 biolink:NamedThing succinate-semialdehyde dehydrogenase (NAD+) activity Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+. got7fsn_ti succinate-semialdehyde dehydrogenase activity|succinyl semialdehyde dehydrogenase activity|succinic semialdehyde dehydrogenase activity|succinate semialdehyde:NAD+ oxidoreductase activity|succinate-semialdehyde:NAD+ oxidoreductase activity|succinate semialdehyde dehydrogenase activity GO:0008952 EC:1.2.1.24|MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN|RHEA:13217|Reactome:R-HSA-888548 molecular_function owl:Class
GO:0009013 biolink:NamedThing succinate-semialdehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. got7fsn_ti succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))|succinate-semialdehyde:NAD(P)+ oxidoreductase activity MetaCyc:SUCCSEMIALDDEHYDROG-RXN|UM-BBD_reactionID:r0371|EC:1.2.1.16 molecular_function owl:Class
GO:0061929 biolink:NamedThing gamma-glutamylaminecyclotransferase activity Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline. got7fsn_ti dph 2017-08-29T14:57:39Z EC:4.3.2.8|RHEA:16961 molecular_function owl:Class
GO:0021902 biolink:NamedThing commitment of neuronal cell to specific neuron type in forebrain The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain. got7fsn_ti biological_process owl:Class
GO:0002352 biolink:NamedThing B cell negative selection Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion. got7fsn_ti B lymphocyte negative selection|B-lymphocyte negative selection|B-cell negative selection biological_process owl:Class
GO:0033115 biolink:NamedThing cyanelle thylakoid membrane The lipid bilayer membrane of any thylakoid within a cyanelle. got7fsn_ti cellular_component owl:Class
GO:0004332 biolink:NamedThing fructose-bisphosphate aldolase activity Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate. got7fsn_ti ketose 1-phosphate aldolase activity|fructose diphosphate aldolase activity|fructose 1,6-diphosphate aldolase activity|D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity|SMALDO|fructose 1-monophosphate aldolase activity|phosphofructoaldolase activity|1,6-diphosphofructose aldolase activity|fructose-1,6-bisphosphate triosephosphate-lyase activity|D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)|aldolase activity|zymohexase activity|diphosphofructose aldolase activity|fructoaldolase activity|fructose 1-phosphate aldolase activity Reactome:R-HSA-71496|MetaCyc:F16ALDOLASE-RXN|Reactome:R-HSA-71495|EC:4.1.2.13|RHEA:14729 molecular_function owl:Class
GO:0034209 biolink:NamedThing sterol acetylation The addition of an acetyl group to a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti biological_process owl:Class
GO:0018711 biolink:NamedThing benzoyl acetate-CoA thiolase activity Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA. got7fsn_ti UM-BBD_reactionID:r0243|MetaCyc:RXN-1305 molecular_function owl:Class
GO:0035695 biolink:NamedThing mitophagy by induced vacuole formation The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes. got7fsn_ti MIV-mediated mitophagy In this mechanism of mitochondrion degradation, the mitochondrion is directly engulfed by a lysosome-like vacuole. It is therefore distinct from canonical autophagy, which is mediated by a double-membrane autophagosome. bf 2011-02-28T03:01:04Z biological_process owl:Class
GO:0039685 biolink:NamedThing rolling hairpin viral DNA replication A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA. got7fsn_ti ssDNA rolling hairpin viral DNA replication bf 2013-10-17T14:33:55Z VZ:2656 biological_process owl:Class
GO:0102601 biolink:NamedThing cytochrome P450 dependent beta-amyrin 16beta-hydroxylase activity Catalysis of the reaction: beta-amyrin + O2 + H+ + NADPH = 16beta-hydroxy-beta-amyrin + H2O + NADP. got7fsn_ti RHEA:55440|EC:1.14.14.63|MetaCyc:RXN-15385 molecular_function owl:Class
GO:0019528 biolink:NamedThing D-arabitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate. got7fsn_ti D-arabitol degradation to xylulose 5-phosphate|D-arabitol utilization|D-arabitol degradation|D-arabitol breakdown to xylulose 5-phosphate MetaCyc:DARABITOLUTIL-PWY biological_process owl:Class
GO:0050263 biolink:NamedThing ribosylpyrimidine nucleosidase activity Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine. got7fsn_ti N-ribosylpyrimidine ribohydrolase activity|nucleoside ribohydrolase activity|N-ribosylpyrimidine nucleosidase activity|YeiK|pyrimidine-nucleoside ribohydrolase activity|pyrimidine nucleosidase activity|RihB RHEA:56816|MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN|EC:3.2.2.8 molecular_function owl:Class
GO:0002751 biolink:NamedThing antigen processing and presentation following receptor mediated endocytosis Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis. got7fsn_ti biological_process owl:Class
GO:0002745 biolink:NamedThing antigen processing and presentation initiated by receptor mediated uptake of antigen Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor. got7fsn_ti biological_process owl:Class
GO:0045116 biolink:NamedThing protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. got7fsn_ti RUB1-protein conjugation Note that currently, the only known substrates of neddylation are cullin family proteins. GO:0019943 biological_process owl:Class
GO:0007625 biolink:NamedThing grooming behavior The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites. got7fsn_ti grooming behaviour biological_process owl:Class
GO:0050736 biolink:NamedThing O-malonyltransferase activity Catalysis of the transfer of a malonyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0102069 biolink:NamedThing zerumbone synthase activity Catalysis of the reaction: 8-hydroxy-alpha-humulene + NAD <=> zerumbone + NADH + H+. got7fsn_ti MetaCyc:RXN-10629|EC:1.1.1.326|RHEA:32327 molecular_function owl:Class
GO:0043257 biolink:NamedThing laminin-8 complex A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains. got7fsn_ti laminin-411 complex cellular_component owl:Class
GO:0043755 biolink:NamedThing alpha-ribazole phosphatase activity Catalysis of the reaction: alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate. got7fsn_ti alpha-ribazole-5'-P phosphatase activity|CobC|alpha-ribazole-5'-phosphate phosphohydrolase activity GO:0019175 MetaCyc:RIBAZOLEPHOSPHAT-RXN|KEGG_REACTION:R04594|RHEA:24456|EC:3.1.3.73 molecular_function owl:Class
GO:0004166 biolink:NamedThing dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate. got7fsn_ti dolichyl phosphate acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity|dolichyl-phosphate N-acetylglucosaminyltransferase activity|UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity|dolichyl phosphate N-acetylglucosaminyltransferase activity|dolichyl-phosphate acetylglucosaminyltransferase activity GO:0004101 RHEA:14693|EC:2.4.1.153|MetaCyc:2.4.1.153-RXN molecular_function owl:Class
GO:0061707 biolink:NamedThing extracellular exosome macropinocytosis The single-organism macropinocytosis process that results in the uptake of an extracellular exosome. got7fsn_ti dph 2015-06-15T16:02:38Z biological_process owl:Class
GO:0044351 biolink:NamedThing macropinocytosis An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size. got7fsn_ti single-organism macropinocytosis|clathrin-independent pinocytosis jl 2011-08-11T10:26:42Z GO:1902538 biological_process owl:Class
GO:0075187 biolink:NamedThing hyphopodium formation The process in which a specialized structure, consisted of stalked, thick-walled, lobed cells of vegetative epiphytic hyphae, is formed, to attach and penetrate the host surface. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti hyphopodium formation on or near host biological_process owl:Class
GO:0004648 biolink:NamedThing O-phospho-L-serine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. got7fsn_ti phosphoserine aminotransferase activity|hydroxypyruvic phosphate--glutamic transaminase activity|3-phosphoserine aminotransferase activity|L-phosphoserine aminotransferase activity|3PHP transaminase activity|PSAT activity|phosphohydroxypyruvic--glutamic transaminase activity|3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity|phosphoserine transaminase activity|PdxC|SerC|phosphohydroxypyruvate transaminase activity GO:0004646 RHEA:14329|MetaCyc:PSERTRANSAM-RXN|Reactome:R-HSA-977333|EC:2.6.1.52 molecular_function owl:Class
GO:0046869 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato diiron disulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato diiron disulphide RESID:AA0331 biological_process owl:Class
GO:0009001 biolink:NamedThing serine O-acetyltransferase activity Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. got7fsn_ti acetyl-CoA:L-serine O-acetyltransferase activity|SATase activity|serine acetyltransferase activity|serine transacetylase activity|L-serine acetyltransferase activity KEGG_REACTION:R00586|MetaCyc:SERINE-O-ACETTRAN-RXN|RHEA:24560|EC:2.3.1.30 molecular_function owl:Class
GO:0016412 biolink:NamedThing serine O-acyltransferase activity Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule. got7fsn_ti EC:2.3.1.30 molecular_function owl:Class
GO:0021519 biolink:NamedThing spinal cord association neuron specification The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway. got7fsn_ti biological_process owl:Class
GO:0097431 biolink:NamedThing mitotic spindle pole Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. got7fsn_ti pr 2012-11-20T09:03:16Z cellular_component owl:Class
GO:0036007 biolink:NamedThing scintillon A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen. got7fsn_ti bf 2011-09-21T03:04:02Z cellular_component owl:Class
GO:0047909 biolink:NamedThing galactolipid O-acyltransferase activity Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = acylmono-beta-D-galactosyl-diacylglycerol + mono-beta-D-galactosylacylglycerol. got7fsn_ti mono-beta-D-galactosyldiacylglycerol:mono-beta-D-galactosyldiacylglycerol acyltransferase activity|galactolipid:galactolipid acyltransferase activity MetaCyc:GALACTOLIPID-O-ACYLTRANSFERASE-RXN|EC:2.3.1.134 molecular_function owl:Class
GO:0031176 biolink:NamedThing endo-1,4-beta-xylanase activity Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans. got7fsn_ti endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity|endo-beta-1,4-xylanase activity|beta-D-xylanase activity|beta-1,4-xylanase activity|endo-1,4-beta-D-xylanase activity|beta-1,4-xylan xylanohydrolase activity|1,4-beta-xylan xylanohydrolase activity|xylanase|beta-xylanase activity|endo-1,4-xylanase activity|1,4-beta-D-xylan xylanohydrolase activity|endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity EC:3.2.1.8|MetaCyc:3.2.1.8-RXN molecular_function owl:Class
GO:0035717 biolink:NamedThing chemokine (C-C motif) ligand 7 binding Binding to chemokine (C-C motif) ligand 7. got7fsn_ti CCL7 binding bf 2011-03-03T04:25:41Z molecular_function owl:Class
GO:0036469 biolink:NamedThing L-tryptophan decarboxylase activity Catalysis of the reaction: L-tryptophan + H+ = CO2 + tryptamine. got7fsn_ti L-tryptophan decarboxylase activity bf 2014-07-21T09:22:24Z EC:4.1.1.105|RHEA:30339 molecular_function owl:Class
GO:0018482 biolink:NamedThing 4-formylbenzenesulfonate dehydrogenase activity Catalysis of the reaction: 4-formylbenzenesulfonate + H(2)O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH. got7fsn_ti toluene-sulfonate aldehyde dehydrogenase activity|4-formylbenzenesulfonate:NAD+ oxidoreductase activity|4-formylbenzenesulphonate dehydrogenase activity RHEA:18833|MetaCyc:1.2.1.62-RXN|EC:1.2.1.62|UM-BBD_reactionID:r0292|KEGG_REACTION:R05272 molecular_function owl:Class
GO:0018187 biolink:NamedThing molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide. got7fsn_ti RESID:AA0281 biological_process owl:Class
GO:0036401 biolink:NamedThing pyrokinin receptor activity Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation. got7fsn_ti PK receptor activity bf 2013-07-18T15:10:55Z molecular_function owl:Class
GO:1990443 biolink:NamedThing peptidyl-threonine autophosphorylation The phosphorylation by a protein of one or more of its own threonine amino acid residues, or a threonine residue on an identical protein. got7fsn_ti al 2014-08-02T15:08:41Z biological_process owl:Class
GO:0102148 biolink:NamedThing N-acetyl-beta-D-galactosaminidase activity Catalysis of the reaction: H2O + an N-acetyl-beta-D-galactosalaminyl-[glycan] = N-acetyl-beta-D-galactosamine + a glycan. got7fsn_ti EC:3.2.1.52|MetaCyc:RXN-11622 molecular_function owl:Class
GO:0031258 biolink:NamedThing lamellipodium membrane The portion of the plasma membrane surrounding a lamellipodium. got7fsn_ti cellular_component owl:Class
GO:0000977 biolink:NamedThing RNA polymerase II transcription regulatory region sequence-specific DNA binding Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. got7fsn_ti RNA polymerase II regulatory region DNA binding https://github.com/geneontology/go-ontology/issues/19312 To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. krc 2010-08-10T11:05:36Z GO:0001012 molecular_function owl:Class
GO:0042272 biolink:NamedThing nuclear RNA export factor complex A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm. got7fsn_ti Mex67-Mtr2 complex|TAP-p15 complex|NXF1-NXT1 complex cellular_component owl:Class
GO:0005359 biolink:NamedThing low-affinity glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. got7fsn_ti low-affinity hydrogen/glucose transporter activity|low-affinity hydrogen:glucose transporter activity|low-affinity hydrogen:glucose symporter activity molecular_function owl:Class
GO:0048491 biolink:NamedThing retrograde synaptic vesicle transport The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body. got7fsn_ti retrograde axonal transport of synaptic vesicle biological_process owl:Class
GO:0034750 biolink:NamedThing Scrib-APC-beta-catenin complex A protein complex that contains the Scribble protein (a cell polarity determinant), the tumor suppressor protein adenomatous polyposis coli (APC), and beta-catenin; may be involved in the control of cell proliferation. got7fsn_ti hScrib-APC-beta-catenin complex Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0019885 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class I The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class I|antigen processing, endogenous antigen via MHC class I|antigen processing, endogenous antigen via major histocompatibility complex class I|antigen presentation, endogenous peptide antigen GO:0048004 biological_process owl:Class
GO:0050929 biolink:NamedThing induction of negative chemotaxis Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. got7fsn_ti biological_process owl:Class
GO:0050924 biolink:NamedThing positive regulation of negative chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical. got7fsn_ti stimulation of negative chemotaxis|up regulation of negative chemotaxis|upregulation of negative chemotaxis|activation of negative chemotaxis|up-regulation of negative chemotaxis biological_process owl:Class
GO:0010427 biolink:NamedThing abscisic acid binding Binding to abscisic acid, a plant hormone that regulates aspects of plant growth. got7fsn_ti abscisate binding|ABA binding molecular_function owl:Class
GO:0016840 biolink:NamedThing carbon-nitrogen lyase activity Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). got7fsn_ti other carbon-nitrogen lyase activity EC:4.3.-.- molecular_function owl:Class
GO:0052543 biolink:NamedThing callose deposition in cell wall Any process in which callose is transported to, and/or maintained in, the cell wall. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. got7fsn_ti cell wall callose deposition|callose localization in cell wall|cell wall callose localization biological_process owl:Class
GO:0045295 biolink:NamedThing gamma-catenin binding Binding to catenin complex gamma subunit. got7fsn_ti plakoglobin binding molecular_function owl:Class
GO:0044598 biolink:NamedThing doxorubicin metabolic process The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy. got7fsn_ti jl 2012-05-01T03:30:21Z biological_process owl:Class
GO:0016137 biolink:NamedThing glycoside metabolic process The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. got7fsn_ti O-glycoside metabolism|O-glycoside metabolic process|glycoside metabolism GO:0016140 biological_process owl:Class
GO:0036510 biolink:NamedThing trimming of terminal mannose on C branch The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. got7fsn_ti conversion of (Man)9(GlcNAc)2 to (Man)8C(GlcNAc)2|conversion of M9 to M8C|glycoprotein mannose trimming on C branch Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. bf 2015-06-11T14:10:52Z biological_process owl:Class
GO:0032411 biolink:NamedThing positive regulation of transporter activity Any process that activates or increases the activity of a transporter. got7fsn_ti activation of transporter activity|up regulation of transporter activity|upregulation of transporter activity|up-regulation of transporter activity|stimulation of transporter activity biological_process owl:Class
GO:0050672 biolink:NamedThing negative regulation of lymphocyte proliferation Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation. got7fsn_ti inhibition of lymphocyte proliferation|down regulation of lymphocyte proliferation|down-regulation of lymphocyte proliferation|downregulation of lymphocyte proliferation biological_process owl:Class
GO:0008741 biolink:NamedThing ribulokinase activity Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate. got7fsn_ti L-ribulokinase activity|ribulokinase (phosphorylating)|ATP:L(or D)-ribulose 5-phosphotransferase activity EC:2.7.1.16|MetaCyc:RIBULOKIN-RXN|RHEA:22072 molecular_function owl:Class
GO:0050323 biolink:NamedThing taurine dehydrogenase activity Catalysis of the reaction: A + H(2)O + taurine = AH(2) + NH(4)(+) + sulfoacetaldehyde. got7fsn_ti taurine:acceptor oxidoreductase (deaminating)|taurine:(acceptor) oxidoreductase (deaminating) MetaCyc:TAURINE-DEHYDROGENASE-RXN|KEGG_REACTION:R07167|EC:1.4.99.2|RHEA:18709 molecular_function owl:Class
GO:0003432 biolink:NamedThing cell growth involved in growth plate cartilage chondrocyte morphogenesis The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time. got7fsn_ti dph 2009-12-22T12:37:48Z biological_process owl:Class
GO:0042659 biolink:NamedThing regulation of cell fate specification Any process that mediates the adoption of a specific fate by a cell. got7fsn_ti biological_process owl:Class
GO:0061635 biolink:NamedThing regulation of protein complex stability Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly. got7fsn_ti dph 2014-08-13T14:40:21Z biological_process owl:Class
GO:0005767 biolink:NamedThing secondary lysosome Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome. got7fsn_ti NIF_Subcellular:sao1549842807 cellular_component owl:Class
GO:1990699 biolink:NamedThing palmitoleyl hydrolase activity Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate. got7fsn_ti sp 2015-03-13T09:00:05Z molecular_function owl:Class
GO:0051318 biolink:NamedThing G1 phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:G1_phase biological_process owl:Class
GO:0016005 biolink:NamedThing phospholipase A2 activator activity Increases the activity of the enzyme phospholipase A2. got7fsn_ti molecular_function owl:Class
GO:0021616 biolink:NamedThing glossopharyngeal nerve formation The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. got7fsn_ti CN IX formation|CN IX biosynthesis biological_process owl:Class
GO:0090486 biolink:NamedThing small RNA 2'-O-methyltransferase Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide. got7fsn_ti tb 2012-10-15T16:32:49Z molecular_function owl:Class
GO:0036159 biolink:NamedThing inner dynein arm assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. got7fsn_ti IDA assembly bf 2012-03-21T02:25:01Z biological_process owl:Class
GO:0070286 biolink:NamedThing axonemal dynein complex assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. got7fsn_ti dynein arm assembly biological_process owl:Class
GO:0045278 biolink:NamedThing plasma membrane respiratory chain complex IV A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species. got7fsn_ti respiratory chain complex IV|cytochrome c oxidase complex GO:0045288 cellular_component owl:Class
GO:0030622 biolink:NamedThing U4atac snRNA binding Binding to a U4atac small nuclear RNA (U4atac snRNA). got7fsn_ti molecular_function owl:Class
GO:0075294 biolink:NamedThing positive regulation by symbiont of entry into host Any process that activates or increases the frequency, rate or extent to which it enters into the host organism, where the two organisms are in a symbiotic interaction. got7fsn_ti up regulation by organism of entry into other organism during symbiotic interaction|positive regulation by organism of entry into other organism involved in symbiotic interaction|up regulation by symbiont of entry into host|positive regulation by organism of entry into other organism during symbiotic interaction|up-regulation by organism of entry into other organism during symbiotic interaction|activation by symbiont of entry into host|upregulation by organism of entry into other organism during symbiotic interaction|up-regulation by symbiont of entry into host|upregulation by symbiont of entry into host|activation by organism of entry into other organism during symbiotic interaction https://github.com/geneontology/go-ontology/issues/19027 GO:0075295 biological_process owl:Class
GO:0035629 biolink:NamedThing N-terminal protein amino acid N-linked glycosylation Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein. got7fsn_ti Note that the only known alpha amino glycosylation is on an asparagine; see UniProtKB:P58522. However, this feature is not differentiated from normal N-glycosylation of asparagine. bf 2010-12-17T10:45:48Z biological_process owl:Class
GO:0060746 biolink:NamedThing parental behavior A reproductive behavior in which a parent cares for and rears offspring. got7fsn_ti dph 2009-06-22T09:05:26Z biological_process owl:Class
GO:0009943 biolink:NamedThing adaxial/abaxial axis specification The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. got7fsn_ti adaxial/abaxial determination biological_process owl:Class
GO:0044721 biolink:NamedThing protein import into peroxisome matrix, substrate release The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane. got7fsn_ti jl 2012-10-18T14:07:40Z biological_process owl:Class
GO:0097726 biolink:NamedThing LEM domain binding Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF). got7fsn_ti LAP2, emerin, MAN1 domain binding|lamina-associated polypeptide, emerin, MAN1 domain binding pr 2016-09-19T10:19:02Z molecular_function owl:Class
GO:0001957 biolink:NamedThing intramembranous ossification Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells. got7fsn_ti dermal ossification|intramembranous bone ossification An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. Wikipedia:Intramembranous_ossification biological_process owl:Class
GO:0005460 biolink:NamedThing UDP-glucose transmembrane transporter activity Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate. got7fsn_ti molecular_function owl:Class
GO:0006560 biolink:NamedThing proline metabolic process The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. got7fsn_ti proline metabolism biological_process owl:Class
GO:0097530 biolink:NamedThing granulocyte migration The movement of a granulocyte within or between different tissues and organs of the body. got7fsn_ti pr 2013-11-11T14:00:44Z biological_process owl:Class
GO:0047134 biolink:NamedThing protein-disulfide reductase (NAD(P)) activity Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. got7fsn_ti insulin-glutathione transhydrogenase activity|NAD(P)H:protein-disulfide oxidoreductase activity|protein-disulfide reductase activity|protein disulphide reductase activity|disulfide reductase activity|protein disulfide reductase (NAD(P)H) activity|protein-disulphide reductase activity|protein disulfide reductase activity https://github.com/geneontology/go-ontology/issues/20219 MetaCyc:1.6.4.4-RXN|EC:1.8.1.8 molecular_function owl:Class
GO:0052020 biolink:NamedThing modification by symbiont of host cell wall The process in which an organism effects a change in the structure or function of the host cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti metabolism of host cell wall by organism biological_process owl:Class
GO:0052333 biolink:NamedThing modification by organism of cell wall of other organism involved in symbiotic interaction The process in which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti metabolism by organism of cell wall of other organism|modification by organism of cell wall of other organism during symbiotic interaction biological_process owl:Class
GO:0031844 biolink:NamedThing type 4 neuropeptide Y receptor binding Binding to a type 4 neuropeptide Y receptor. got7fsn_ti pancreatic polypeptide receptor binding|type 4 neuropeptide Y receptor ligand molecular_function owl:Class
GO:0031841 biolink:NamedThing neuropeptide Y receptor binding Binding to a neuropeptide Y receptor. got7fsn_ti neuropeptide Y receptor ligand|NPY receptor binding molecular_function owl:Class
GO:0018620 biolink:NamedThing phthalate 4,5-dioxygenase activity Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+). got7fsn_ti PDO activity|phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)|phthalate dioxygenase activity EC:1.14.12.7|UM-BBD_reactionID:r0102|KEGG_REACTION:R03630|RHEA:17489|MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN molecular_function owl:Class
GO:0061422 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter in response to alkalinity dph 2012-01-26T12:42:21Z biological_process owl:Class
GO:0071469 biolink:NamedThing cellular response to alkaline pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti cellular response to basic pH|cellular response to alkalinity mah 2009-12-18T11:42:47Z biological_process owl:Class
GO:0032148 biolink:NamedThing activation of protein kinase B activity Any process that initiates the activity of the inactive enzyme protein kinase B. got7fsn_ti protein kinase B activation biological_process owl:Class
GO:1990636 biolink:NamedThing reproductive senescence A natural reduction in reproductive capacity with aging, often taking the form of a switch from regular reproductive cycles to irregular and infrequent ones. got7fsn_ti sl 2015-02-10T23:17:56Z biological_process owl:Class
GO:0031426 biolink:NamedThing polycistronic mRNA processing The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules. got7fsn_ti biological_process owl:Class
GO:0006813 biolink:NamedThing potassium ion transport The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti potassium ion conductance|cellular potassium ion transport|low voltage-dependent potassium channel auxiliary protein activity|low voltage-gated potassium channel auxiliary protein activity|potassium conductance|sodium/potassium transport|potassium transport|K+ conductance mah 2010-09-03T02:39:22Z GO:0071804|GO:0015458 biological_process owl:Class
GO:0016473 biolink:NamedThing sodium ion-transporting F-type ATPase complex A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism. got7fsn_ti sodium-translocating F-type ATPase complex cellular_component owl:Class
GO:0004736 biolink:NamedThing pyruvate carboxylase activity Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate. got7fsn_ti pyruvate:carbon-dioxide ligase (ADP-forming)|pyruvic carboxylase activity EC:6.4.1.1|MetaCyc:PYRUVATE-CARBOXYLASE-RXN|KEGG_REACTION:R00344|RHEA:20844|Reactome:R-HSA-70501 molecular_function owl:Class
GO:0050128 biolink:NamedThing N-feruloylglycine deacylase activity Catalysis of the reaction: N-feruloylglycine + H(2)O = ferulate + glycine. got7fsn_ti N-feruloylglycine amidohydrolase activity|N-feruloylglycine hydrolase activity EC:3.5.1.71|KEGG_REACTION:R03579|MetaCyc:N-FERULOYLGLYCINE-DEACYLASE-RXN|RHEA:10484 molecular_function owl:Class
GO:0060344 biolink:NamedThing liver trabecula formation The process of creating a trabecula in the liver. A trabecula is a tissue element in the form of a small beam, strut or rod. got7fsn_ti liver trabecula biogenesis|liver trabeculation biological_process owl:Class
GO:0014855 biolink:NamedThing striated muscle cell proliferation The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. got7fsn_ti biological_process owl:Class
GO:0033002 biolink:NamedThing muscle cell proliferation The expansion of a muscle cell population by cell division. got7fsn_ti myocyte proliferation biological_process owl:Class
GO:0097402 biolink:NamedThing neuroblast migration The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. got7fsn_ti pr 2012-10-29T08:24:37Z biological_process owl:Class
GO:0014064 biolink:NamedThing positive regulation of serotonin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin. got7fsn_ti positive regulation of serotonin release|up-regulation of serotonin secretion|stimulation of serotonin secretion|up regulation of serotonin secretion|upregulation of serotonin secretion|activation of serotonin secretion biological_process owl:Class
GO:0003390 biolink:NamedThing dendrite development by retrograde extension The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point. got7fsn_ti dendrite retrograde extension dph 2009-12-09T09:25:24Z biological_process owl:Class
GO:0034611 biolink:NamedThing oligoribonucleotidase activity Catalysis of the exonucleolytic cleavage of oligoribonucleotides to yield ribonucleoside 5'-phosphates. got7fsn_ti RNA oligonucleotidase activity Reactome:R-HSA-9009950|Reactome:R-HSA-9615042 molecular_function owl:Class
GO:0008946 biolink:NamedThing oligonucleotidase activity Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates. got7fsn_ti Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP. EC:3.1.13.3|MetaCyc:3.1.13.3-RXN molecular_function owl:Class
GO:0018643 biolink:NamedThing carbon disulfide oxygenase activity Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide. got7fsn_ti carbon disulphide oxygenase activity EC:1.14.13.-|UM-BBD_reactionID:r0599 molecular_function owl:Class
GO:0033445 biolink:NamedThing AGU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AGU codon. got7fsn_ti AGT codon-amino acid adaptor activity|serine tRNA Note that in the standard genetic code, AGT codes for serine. molecular_function owl:Class
GO:0003317 biolink:NamedThing cardioblast cell midline fusion The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment. got7fsn_ti cardiac progenitor cell midline fusion dph 2009-10-27T09:08:57Z biological_process owl:Class
GO:0034109 biolink:NamedThing homotypic cell-cell adhesion The attachment of a cell to a second cell of the identical type via adhesion molecules. got7fsn_ti Note that this term is not synonymous with 'homophilic cell adhesion ; GO:0007156'; the process may occur by homophilic or heterophilic mechanisms. biological_process owl:Class
GO:0043777 biolink:NamedThing cobalt-precorrin-7 C15-methyltransferase activity Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2. got7fsn_ti precorrin-6Y methylase|cobalt-precorrin 7 C15-methyltransferase activity|precorrin-6 methyltransferase|precorrin-6Y C5,15-methyltransferase (decarboxylating) RHEA:34591|MetaCyc:RXN-8767 molecular_function owl:Class
GO:0097081 biolink:NamedThing vascular associated smooth muscle cell fate commitment The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. got7fsn_ti vascular smooth muscle cell fate commitment pr 2011-06-20T03:51:52Z biological_process owl:Class
GO:0035579 biolink:NamedThing specific granule membrane The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. got7fsn_ti secondary granule membrane bf 2010-10-05T01:32:47Z cellular_component owl:Class
GO:0047111 biolink:NamedThing formate dehydrogenase (cytochrome-c-553) activity Catalysis of the reaction: ferricytochrome C-553 + formate = ferrocytochrome C-553 + CO2. got7fsn_ti formate dehydrogenase (cytochrome c-553)|formate:ferricytochrome-c-553 oxidoreductase activity RHEA:15189|MetaCyc:1.2.2.3-RXN|EC:1.17.2.3 molecular_function owl:Class
GO:0140164 biolink:NamedThing Golgi transport complex binding Binding to a Golgi transport complex, a multisubunit tethering complex of the CATCHR family. got7fsn_ti COG complex binding pg 2018-02-08T11:49:38Z molecular_function owl:Class
GO:0102853 biolink:NamedThing 1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity Catalysis of the reaction: 1-18:1-2-18:1-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8320 molecular_function owl:Class
GO:0005138 biolink:NamedThing interleukin-6 receptor binding Binding to an interleukin-6 receptor. got7fsn_ti IL-6|interleukin-6 receptor ligand molecular_function owl:Class
GO:0017103 biolink:NamedThing UTP:galactose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose. got7fsn_ti UTP-hexose-1-phosphate uridylyltransferase activity|galactose 1-phosphate uridyltransferase activity|galactose 1-phosphate uridylyltransferase activity|UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity|galactose-1-phosphate uridylyltransferase activity|uridine diphosphogalactose pyrophosphorylase activity|uridine diphosphate galactose pyrophosphorylase activity|UTP:hexose-1-phosphate uridylyltransferase activity|Gal-1-P uridylyltransferase activity|UDPgalactose pyrophosphorylase activity|alpha-D-galactose 1-phosphate uridylyltransferase activity GO:0003982 RHEA:14209|KEGG_REACTION:R00502|EC:2.7.7.10|MetaCyc:UTPHEXPURIDYLYLTRANS-RXN molecular_function owl:Class
GO:0016797 biolink:NamedThing exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters. got7fsn_ti Note that this activity can catalyze cleavage of DNA or RNA. EC:3.1.16.- molecular_function owl:Class
GO:0033474 biolink:NamedThing indoleacetic acid conjugate biosynthetic process The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid conjugate, a form of indoleacetic acid covalently bound to another molecule. got7fsn_ti indoleacetic acid conjugate biosynthesis|indoleacetic acid conjugate anabolism|indole acetic acid conjugate biosynthesis|indole acetic acid conjugate biosynthetic process|indoleacetic acid conjugate synthesis|indoleacetic acid conjugate formation|IAA conjugate biosynthetic process biological_process owl:Class
GO:0016741 biolink:NamedThing transferase activity, transferring one-carbon groups Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). got7fsn_ti methyltransferase activity https://github.com/geneontology/go-ontology/issues/20486 EC:2.1.-.- molecular_function owl:Class
GO:0030633 biolink:NamedThing D-alanine family amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids. got7fsn_ti D-alanine family amino acid catabolism|D-alanine family amino acid degradation|D-alanine family amino acid breakdown biological_process owl:Class
GO:2000947 biolink:NamedThing positive regulation of amylopectin catabolic process Any process that activates or increases the frequency, rate or extent of amylopectin catabolic process. got7fsn_ti positive regulation of Amylopectin catabolism tt 2011-08-01T02:15:32Z biological_process owl:Class
GO:2000883 biolink:NamedThing positive regulation of starch catabolic process Any process that activates or increases the frequency, rate or extent of starch catabolic process. got7fsn_ti positive regulation of starch breakdown|positive regulation of starch degradation|positive regulation of starch catabolism bf 2011-07-27T03:23:51Z biological_process owl:Class
GO:0018005 biolink:NamedThing N-terminal peptidyl-glycine N-formylation The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine. got7fsn_ti RESID:AA0057 biological_process owl:Class
GO:0018004 biolink:NamedThing N-terminal protein formylation The formylation of the N-terminal amino acid of proteins. got7fsn_ti biological_process owl:Class
GO:0034943 biolink:NamedThing trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi. got7fsn_ti UM-BBD_reactionID:r0989 molecular_function owl:Class
GO:0047425 biolink:NamedThing 1-pyrroline-4-hydroxy-2-carboxylate deaminase activity Catalysis of the reaction: 4-hydroxy-1-pyrroline-2-carboxylate + H(2)O + H(+) = 2,5-dioxopentanoate + NH(4)(+). got7fsn_ti HPC deaminase activity|1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing) EC:3.5.4.22|RHEA:10560|KEGG_REACTION:R02280|MetaCyc:3.5.4.22-RXN molecular_function owl:Class
GO:0010438 biolink:NamedThing cellular response to sulfur starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur. got7fsn_ti biological_process owl:Class
GO:0089719 biolink:NamedThing RHG protein domain binding Binding to an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif). got7fsn_ti RHG domain binding|inhibitor of apoptosis binding domain binding|reaper hid grim domain binding|iap binding domain binding molecular_function owl:Class
GO:1902104 biolink:NamedThing positive regulation of metaphase/anaphase transition of meiotic cell cycle Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. got7fsn_ti up-regulation of metaphase/anaphase transition of meiotic cell cycle|activation of metaphase/anaphase transition of meiotic cell cycle|activation of meiotic metaphase/anaphase transition|positive regulation of meiotic metaphase/anaphase transition|upregulation of metaphase/anaphase transition of meiotic cell cycle|up-regulation of meiotic metaphase/anaphase transition|upregulation of meiotic metaphase/anaphase transition|up regulation of meiotic metaphase/anaphase transition|up regulation of metaphase/anaphase transition of meiotic cell cycle jl 2013-05-02T12:45:48Z biological_process owl:Class
GO:1905134 biolink:NamedThing positive regulation of meiotic chromosome separation Any process that activates or increases the frequency, rate or extent of meiotic chromosome separation. got7fsn_ti activation of meiotic chromosome separation|up-regulation of chromosome separation during meiosis|upregulation of meiotic chromosome resolution|up regulation of meiotic chromosome separation|up regulation of chromosome separation during meiosis|positive regulation of meiotic chromosome resolution|upregulation of meiotic chromosome separation|positive regulation of chromosome separation during meiosis|activation of chromosome separation during meiosis|up-regulation of meiotic chromosome separation|activation of meiotic chromosome resolution|up-regulation of meiotic chromosome resolution|upregulation of chromosome separation during meiosis|up regulation of meiotic chromosome resolution dph 2016-04-12T17:46:45Z biological_process owl:Class
GO:0099630 biolink:NamedThing postsynaptic neurotransmitter receptor cycle The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane. got7fsn_ti biological_process owl:Class
GO:0099627 biolink:NamedThing neurotransmitter receptor cycle The process during which neurotransmitter receptors, anchored in some region of the synaptic membrane, are recycled via the endosome. This cycle includes release from anchoring, diffusion in the synaptic membrane to an endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent anchoring (trapping). got7fsn_ti biological_process owl:Class
GO:0061750 biolink:NamedThing acid sphingomyelin phosphodiesterase activity Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in an acidic environment. got7fsn_ti acid SMase|acid sphingomyelinase dph 2015-11-11T14:47:45Z molecular_function owl:Class
GO:0036526 biolink:NamedThing peptidyl-cysteine deglycation The removal of a sugar or dicarbonyl from a cysteine residue of a glycated protein. got7fsn_ti deglycation of N-acetylcysteine bf 2016-08-04T10:35:25Z biological_process owl:Class
GO:0046826 biolink:NamedThing negative regulation of protein export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm. got7fsn_ti negative regulation of protein transport from nucleus to cytoplasm|downregulation of protein export from nucleus|down-regulation of protein export from nucleus|down regulation of protein export from nucleus|inhibition of protein export from nucleus|negative regulation of protein-nucleus export|negative regulation of protein export out of nucleus|negative regulation of protein export from cell nucleus biological_process owl:Class
GO:0051457 biolink:NamedThing maintenance of protein location in nucleus Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus. got7fsn_ti nuclear protein retention|sequestration of protein in nucleus|maintenance of protein localization in nucleus|protein retention in nucleus|protein-nuclear retention|nuclear protein sequestration|storage of protein in nucleus|nuclear protein sequestering|protein sequestration in nucleus|maintenance of nuclear protein localization|protein storage in nucleus|maintenance of protein location in cell nucleus biological_process owl:Class
GO:0120195 biolink:NamedThing positive regulation of anther dehiscence Any process that activates or increases the frequency, rate or extent of anther dehiscence. got7fsn_ti krc 2019-04-09T21:58:31Z biological_process owl:Class
GO:0005220 biolink:NamedThing inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. got7fsn_ti InsP3 receptor|inositol-1,4,5-trisphosphate receptor activity|IP3 receptor activity GO:0008095 molecular_function owl:Class
GO:0010845 biolink:NamedThing positive regulation of reciprocal meiotic recombination Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. got7fsn_ti positive regulation of meiotic recombination biological_process owl:Class
GO:0031298 biolink:NamedThing replication fork protection complex A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling. got7fsn_ti replisome progression complex|Swi1-Swi3 complex|TIMELESS-TIPIN complex cellular_component owl:Class
GO:0002300 biolink:NamedThing CD8-positive, alpha-beta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti CD8-positive, alpha-beta intraepithelial T-cell differentiation|CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation|CD8-positive, alpha-beta intraepithelial T cell development|CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0050936 biolink:NamedThing xanthophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance. got7fsn_ti xanthophore cell differentiation Note that this term refers to xanthophores in the sense of specialized pigment-producing cells, and should not be confused with the cellular component term 'xanthophore ; GO:0031633', which refers to a subcellular structure. biological_process owl:Class
GO:0046841 biolink:NamedThing trisporic acid metabolic process The chemical reactions and pathways involving trisporic acid, a carotenoic acid derivative used as a pheromone in some species of Zygomycota. got7fsn_ti trisporic acid metabolism biological_process owl:Class
GO:0010015 biolink:NamedThing root morphogenesis The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support. got7fsn_ti biological_process owl:Class
GO:0047242 biolink:NamedThing hydroxyanthraquinone glucosyltransferase activity Catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP. got7fsn_ti uridine diphosphoglucose-anthraquinone glucosyltransferase activity|UDP-glucose:hydroxyanthraquinone O-glucosyltransferase activity|anthraquinone-specific glucosyltransferase activity|UDPglucose:hydroxyanthraquinone O-glucosyltransferase activity MetaCyc:2.4.1.181-RXN|EC:2.4.1.181 molecular_function owl:Class
GO:0021522 biolink:NamedThing spinal cord motor neuron differentiation The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0036252 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to menadione Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter in response to menadione stress bf 2012-06-12T11:40:58Z biological_process owl:Class
GO:0098986 biolink:NamedThing T-bar A T-shaped presynpatic density. These are common in arhropod central nervous systems. got7fsn_ti cellular_component owl:Class
GO:0098980 biolink:NamedThing presynaptic density An electron dense specialization of the presynaptic active zone cytoskeleton. got7fsn_ti cellular_component owl:Class
GO:0140640 biolink:NamedThing catalytic activity, acting on a nucleic acid Catalytic activity that acts to modify a nucleic acid. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21402 pg 2021-05-11T06:31:07Z molecular_function owl:Class
GO:1901321 biolink:NamedThing positive regulation of heart induction Any process that activates or increases the frequency, rate or extent of heart induction. got7fsn_ti up-regulation of heart induction|upregulation of heart induction|up regulation of heart induction|activation of heart induction bf 2012-08-28T15:49:51Z biological_process owl:Class
GO:0090421 biolink:NamedThing embryonic meristem initiation Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation. got7fsn_ti tb 2012-04-13T02:52:34Z biological_process owl:Class
GO:0018886 biolink:NamedThing anaerobic carbon tetrachloride metabolic process The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen. got7fsn_ti anaerobic carbon tetrachloride metabolism UM-BBD_pathwayID:ctc biological_process owl:Class
GO:0018885 biolink:NamedThing carbon tetrachloride metabolic process The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants. got7fsn_ti carbon tetrachloride metabolism UM-BBD_pathwayID:ctc biological_process owl:Class
GO:0030620 biolink:NamedThing U2 snRNA binding Binding to a U2 small nuclear RNA (U2 snRNA). got7fsn_ti molecular_function owl:Class
GO:1900052 biolink:NamedThing regulation of retinoic acid biosynthetic process Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process. got7fsn_ti regulation of retinoic acid anabolic process yaf 2012-01-20T09:55:45Z biological_process owl:Class
GO:0070002 biolink:NamedThing glutamic-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. got7fsn_ti molecular_function owl:Class
GO:0004328 biolink:NamedThing formamidase activity Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+). got7fsn_ti formamide hydrolase activity|formamide amidohydrolase activity GO:0034566 RHEA:21948|EC:3.5.1.49|MetaCyc:FORMAMIDASE-RXN|UM-BBD_reactionID:r0873|KEGG_REACTION:R00524 molecular_function owl:Class
GO:0032334 biolink:NamedThing inhibin secretion The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone. got7fsn_ti biological_process owl:Class
GO:0070255 biolink:NamedThing regulation of mucus secretion Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue. got7fsn_ti regulation of mucus production biological_process owl:Class
GO:0045228 biolink:NamedThing slime layer polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall. got7fsn_ti slime layer polysaccharide synthesis|slime layer polysaccharide anabolism|slime layer polysaccharide biosynthesis|slime layer polysaccharide formation biological_process owl:Class
GO:0045226 biolink:NamedThing extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. got7fsn_ti extracellular polysaccharide synthesis|extracellular polysaccharide formation|extracellular polysaccharide biosynthesis|extracellular polysaccharide anabolism biological_process owl:Class
GO:1990040 biolink:NamedThing sub-surface cisterna Specialization of the hypolemmal cisterna consisting of either single profiles or closely apposed stacks of endoplasmic reticulum in which the lumen is obliterated, lying 10-20 nm beneath the plasma membrane. got7fsn_ti sub-surface cisternae pr 2013-02-11T15:10:47Z NIF_Subcellular:sao128470897 cellular_component owl:Class
GO:1990039 biolink:NamedThing hypolemmal cisterna Specialized part of the smooth endoplasmic reticulum that closely underlies the plasma membrane, usually within 60 nm or closer. got7fsn_ti hypolemmal cisternae pr 2013-02-11T15:04:56Z NIF_Subcellular:sao1634374950 cellular_component owl:Class
GO:0004938 biolink:NamedThing alpha2-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. got7fsn_ti alpha2 adrenoceptor molecular_function owl:Class
GO:0004936 biolink:NamedThing alpha-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors. got7fsn_ti alpha adrenoceptor molecular_function owl:Class
GO:0080191 biolink:NamedThing secondary thickening Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of tissue from a secondary thickening meristem. got7fsn_ti Occurs in shoot axes in some monocotyledons such as Dracaena, and rarely in roots of monocotyledons. Distinct from primary thickening, because it is distant from and generally discontinuous with the apical meristem. dhl 2012-12-06T15:50:33Z biological_process owl:Class
GO:0018301 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon RESID:AA0268 biological_process owl:Class
GO:1903114 biolink:NamedThing silver ion transmembrane transporter complex A protein complex which is capable of silver ion transmembrane transporter activity. got7fsn_ti An example of this is CusA in E. coli (UniProt symbol P38054) in PMID:11283292 (inferred from direct assay). bhm 2014-06-10T10:00:02Z cellular_component owl:Class
GO:0031991 biolink:NamedThing regulation of actomyosin contractile ring contraction Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle. got7fsn_ti regulation of contractile ring contraction involved in cell cycle cytokinesis|regulation of actomyosin contractile ring constriction|regulation of contractile ring contraction involved in cytokinesis during cell cycle https://github.com/geneontology/go-ontology/issues/21855 biological_process owl:Class
GO:0102545 biolink:NamedThing phosphatidyl phospholipase B activity Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate. got7fsn_ti MetaCyc:RXN-14899|EC:3.1.1.5 molecular_function owl:Class
GO:0019460 biolink:NamedThing glutamine catabolic process to fumarate The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate. got7fsn_ti glutamate catabolic process to fumarate|glutamine breakdown to fumarate|glutamine degradation to fumarate biological_process owl:Class
GO:1990310 biolink:NamedThing type-III dockerin domain binding Binding to a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain. got7fsn_ti tt 2014-03-07T03:22:36Z molecular_function owl:Class
GO:0047772 biolink:NamedThing carboxymethyloxysuccinate lyase activity Catalysis of the reaction: carboxymethoxysuccinate = fumarate + glycolate. got7fsn_ti carboxymethyloxysuccinate glycolate-lyase (fumarate-forming)|carboxymethyloxysuccinate glycolate-lyase activity MetaCyc:CARBOXYMETHYLOXYSUCCINATE-LYASE-RXN|EC:4.2.99.12|RHEA:12336|KEGG_REACTION:R01336 molecular_function owl:Class
GO:0031421 biolink:NamedThing invertasome A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts. got7fsn_ti cellular_component owl:Class
GO:0010691 biolink:NamedThing negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. got7fsn_ti biological_process owl:Class
GO:0102775 biolink:NamedThing 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone synthase activity Catalysis of the reaction: 2 H+ + isovaleryl-CoA + 3 malonyl-CoA = 6-(4-methyl-2-oxopentyl)-4-hydroxy-2-pyrone + 4 coenzyme A + 3 carbon dioxide. got7fsn_ti MetaCyc:RXN-7826 molecular_function owl:Class
GO:0103073 biolink:NamedThing anandamide amidohydrolase activity Catalysis of the reaction: anandamide + H2O <=> arachidonate + ethanolaminium(1+). got7fsn_ti MetaCyc:RXN6666-2|EC:3.5.1.99|RHEA:26136 molecular_function owl:Class
GO:0102395 biolink:NamedThing 9-cis-beta-carotene 9',10'-cleavage oxygenase activity Catalysis of the reaction: 9-cis-beta-carotene + O2 <=> 9-cis-10'-apo-beta-carotenal + beta-ionone. got7fsn_ti EC:1.13.11.68|RHEA:34399|MetaCyc:RXN-13642 molecular_function owl:Class
GO:0097569 biolink:NamedThing lateral shield Region of the ventral side of the cell body found in Giardia species (trophozoite stage). It is located posterior on either side of the ventral groove; the upper boundary is the ventral disc, and the lower boundary is marked by the posteriolateral flagella. got7fsn_ti Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-11T13:37:10Z cellular_component owl:Class
GO:0048874 biolink:NamedThing host-mediated regulation of intestinal microbiota composition The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut. got7fsn_ti homeostasis of number of cells in a free-living population|host-induced regulation of intestinal microbiota composition https://github.com/geneontology/go-ontology/issues/15748 biological_process owl:Class
GO:0032311 biolink:NamedThing angiogenin-PRI complex A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis. got7fsn_ti angiogenin-placental ribonuclease inhibitor complex cellular_component owl:Class
GO:0070983 biolink:NamedThing dendrite guidance The process in which the migration of a dendrite is directed to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti dendritic guidance mah 2009-10-27T03:53:23Z biological_process owl:Class
GO:0030604 biolink:NamedThing 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH. got7fsn_ti 2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)|1-deoxy-D-xylulose-5-phosphate isomeroreductase activity|DOXP reductoisomerase activity|1-deoxyxylulose-5-phosphate reductoisomerase activity|DXP-reductoisomerase activity|2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity EC:1.1.1.267|MetaCyc:DXPREDISOM-RXN|KEGG_REACTION:R05688|RHEA:13717 molecular_function owl:Class
GO:0043135 biolink:NamedThing 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+. got7fsn_ti PRPP pyrophosphatase activity MetaCyc:RXN-10969 molecular_function owl:Class
GO:0010348 biolink:NamedThing lithium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in). got7fsn_ti lithium:hydrogen antiporter activity molecular_function owl:Class
GO:0034468 biolink:NamedThing glycosome lumen The volume enclosed by the membrane of a glycosome. got7fsn_ti cellular_component owl:Class
GO:0036367 biolink:NamedThing light adaption The ability of a photoreceptor to adjust to varying levels of light. got7fsn_ti Light adaptation is usually a combination of cell desensitization and response acceleration. bf 2012-09-26T13:28:14Z biological_process owl:Class
GO:0071373 biolink:NamedThing cellular response to luteinizing hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. got7fsn_ti mah 2009-12-11T03:16:02Z biological_process owl:Class
GO:0034699 biolink:NamedThing response to luteinizing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a luteinizing hormone stimulus. got7fsn_ti response to luteinizing hormone stimulus biological_process owl:Class
GO:0047899 biolink:NamedThing formate dehydrogenase (NADP+) activity Catalysis of the reaction: formate + NADP(+) = CO(2) + NADPH. got7fsn_ti NADP-dependent formate dehydrogenase activity|formate:NADP+ oxidoreductase activity KEGG_REACTION:R00134|EC:1.17.1.10|RHEA:12000|MetaCyc:FORMATE-DEHYDROGENASE-NADP+-RXN molecular_function owl:Class
GO:0009700 biolink:NamedThing indole phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response. got7fsn_ti indole phytoalexin synthesis|indole phytoalexin anabolism|indole phytoalexin biosynthesis|indole phytoalexin formation biological_process owl:Class
GO:0106293 biolink:NamedThing NADH oxidase H202-forming activity Catalysis of the reaction: NADH + H+ + O2 = NAD + hydrogen peroxide (H2O2). got7fsn_ti hjd 2020-08-19T17:35:22Z RHEA:11264 molecular_function owl:Class
GO:0047992 biolink:NamedThing hydroxylysine kinase activity Catalysis of the reaction: erythro-5-hydroxy-L-lysine + GTP = 5-phosphonooxy-L-lysine + GDP + 2 H(+). got7fsn_ti hydroxylysine kinase (phosphorylating)|GTP:5-hydroxy-L-lysine O-phosphotransferase activity|guanosine triphosphate:5-hydroxy-L-lysine O-phosphotransferase activity EC:2.7.1.81|Reactome:R-HSA-6788611|RHEA:19049|MetaCyc:HYDROXYLYSINE-KINASE-RXN|KEGG_REACTION:R03378 molecular_function owl:Class
GO:0102178 biolink:NamedThing 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl-ergosta-7,24(241)-dien-3beta-ol + O2 + NADH <=> 4alpha-carboxy-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O. got7fsn_ti MetaCyc:RXN-11932|RHEA:58880 molecular_function owl:Class
GO:0070654 biolink:NamedThing sensory epithelium regeneration The regrowth of a sensory epithelium following its loss or destruction. got7fsn_ti mah 2009-05-28T04:02:27Z biological_process owl:Class
GO:0008314 biolink:NamedThing gurken signaling pathway The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to a ligand Gurken. got7fsn_ti gurken receptor signaling pathway|gurken-activated signaling pathway|signaling by Gurken|gurken receptor signalling pathway biological_process owl:Class
GO:0102158 biolink:NamedThing very-long-chain 3-hydroxyacyl-CoA dehydratase activity Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA = H2O + a very-long-chain trans-2,3-dehydroacyl-CoA. got7fsn_ti MetaCyc:RXN-11750|RHEA:45812|EC:4.2.1.134 molecular_function owl:Class
GO:0018442 biolink:NamedThing peptidyl-glutamic acid esterification The addition of an ester group to a glutamic acid residue in a protein. got7fsn_ti biological_process owl:Class
GO:0046783 biolink:NamedThing modification by virus of host polysomes Any viral process that interferes with and inhibits the assembly and function of polysomes. got7fsn_ti viral perturbation of polysomes See also the cellular component term 'polysome ; GO:0005844'. biological_process owl:Class
GO:0061769 biolink:NamedThing ribosylnicotinate kinase activity Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H(+) + nicotinate mononucleotide. got7fsn_ti dph 2016-05-05T14:41:44Z Reactome:R-HSA-8869607|Reactome:R-HSA-8869606 molecular_function owl:Class
GO:0032491 biolink:NamedThing detection of molecule of fungal origin The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal. got7fsn_ti detection of fungal associated molecule|detection of fungus associated molecule biological_process owl:Class
GO:0045610 biolink:NamedThing regulation of hemocyte differentiation Any process that modulates the frequency, rate or extent of hemocyte differentiation. got7fsn_ti regulation of arthropod blood cell differentiation biological_process owl:Class
GO:0030921 biolink:NamedThing peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues. got7fsn_ti RESID:AA0183 biological_process owl:Class
GO:0035890 biolink:NamedThing exit from host The directed movement of an organism out of the body, tissues or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ejection from host bf 2011-06-15T02:08:03Z biological_process owl:Class
GO:0048803 biolink:NamedThing imaginal disc-derived male genitalia morphogenesis The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc. got7fsn_ti male genital morphogenesis biological_process owl:Class
GO:0045461 biolink:NamedThing sterigmatocystin biosynthetic process The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. got7fsn_ti sterigmatocystin anabolism|sterigmatocystin formation|sterigmatocystin synthesis|sterigmatocystin biosynthesis biological_process owl:Class
GO:0000124 biolink:NamedThing SAGA complex A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). got7fsn_ti Spt-Ada-Gcn5-acetyltransferase complex|STAGA complex|SPT3-TAF9-PCAF acetylase complex|STAGA coactivator complex|PCAF histone acetylase-associated complex|PCAF complex|SPT3-TAF9-GCN5 acetylase complex GO:0030914|GO:0000125 cellular_component owl:Class
GO:0097198 biolink:NamedThing histone H3-K36 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone. got7fsn_ti pr 2011-12-05T01:19:45Z biological_process owl:Class
GO:1990696 biolink:NamedThing USH2 complex A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7. got7fsn_ti USH2 quaternary protein complex krc 2015-03-12T17:29:18Z cellular_component owl:Class
GO:0098762 biolink:NamedThing meiotic cell cycle phase One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. got7fsn_ti This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0050630 biolink:NamedThing (iso)eugenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol. got7fsn_ti isoeugenol O-methyltransferase activity|S-adenosyl-L-methionine:isoeugenol O-methyltransferase activity EC:2.1.1.146|MetaCyc:2.1.1.146-RXN|RHEA:17081 molecular_function owl:Class
GO:0060651 biolink:NamedThing regulation of epithelial cell proliferation involved in mammary gland bud elongation Any process that modulates the frequency, rate or extent of mammary gland bud epithelial cell proliferation that results in the elongation of the bud. got7fsn_ti dph 2009-05-29T08:57:18Z biological_process owl:Class
GO:0038102 biolink:NamedThing activin receptor antagonist activity Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor. got7fsn_ti This term refers to inhibition of a member of the activin receptor family; activin receptors bind to multiple ligands including activin and nodal. bf 2012-02-17T11:28:59Z molecular_function owl:Class
GO:0002314 biolink:NamedThing germinal center B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA). got7fsn_ti germinal center B lymphocyte differentiation|germinal center B-cell differentiation|germinal center B-lymphocyte differentiation|germinal center B cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0034852 biolink:NamedThing 4,4-dimethyl-3-oxopentanal dehydrogenase activity Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1309 molecular_function owl:Class
GO:0050022 biolink:NamedThing L-arabinose 1-dehydrogenase (NAD+) activity Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH. got7fsn_ti L-arabinose:NAD+ 1-oxidoreductase activity|L-arabinose 1-dehydrogenase activity EC:1.1.1.46|MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN|RHEA:17925 molecular_function owl:Class
GO:0090676 biolink:NamedThing calcium ion transmembrane transport via low voltage-gated calcium channel A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel. got7fsn_ti generation of T-type calcium current tb 2016-03-23T10:15:23Z biological_process owl:Class
GO:0003070 biolink:NamedThing regulation of systemic arterial blood pressure by neurotransmitter The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. got7fsn_ti biological_process owl:Class
GO:0061651 biolink:NamedThing Atg12 conjugating enzyme activity Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y -> Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:17:36Z molecular_function owl:Class
GO:0070384 biolink:NamedThing Harderian gland development The process whose specific outcome is the progression of the Harderian gland over time, from its formation to the mature structure. The Harderian gland is an anterior orbital structure usually associated with the nictitating membrane, and produces and secretes a variety of substances to the eye, depending upon the species. got7fsn_ti Note that the Harderian gland is found in all terrestrial vertebrate groups, including amphibia, reptiles, birds, and mammals. However, it appears to be absent in certain mammals such as bats, cows, horses, and higher primates. Though largely absent in the adult human, it is present in the fetal and neonatal stages. biological_process owl:Class
GO:0006933 biolink:NamedThing negative regulation of cell adhesion involved in substrate-bound cell migration The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction. got7fsn_ti substrate-bound cell migration, cell release from substrate biological_process owl:Class
GO:0043280 biolink:NamedThing positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process. got7fsn_ti positive regulation of caspase activity|activation of caspase activity|up regulation of caspase activity|stimulation of caspase activity|upregulation of caspase activity|up-regulation of caspase activity biological_process owl:Class
GO:0075317 biolink:NamedThing ascus development The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed. got7fsn_ti Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. biological_process owl:Class
GO:0000810 biolink:NamedThing diacylglycerol diphosphate phosphatase activity Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate. got7fsn_ti diacylglycerol pyrophosphate phosphatase activity|DGPP phosphohydrolase activity|DGPP phosphatase activity RHEA:27449|MetaCyc:RXN-11277|EC:3.1.3.81 molecular_function owl:Class
GO:0052602 biolink:NamedThing 4-chloronitrobenzene nitroreductase activity Catalysis of the reaction: 4-chloronitrobenzene + NADPH + H+ = 1-chloro-4-nitrosobenzene + NADP+ + H2O. got7fsn_ti UM-BBD_enzymeID:e0245|MetaCyc:RXN-8833 molecular_function owl:Class
GO:0051730 biolink:NamedThing GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: GTP + 5'-dephospho-RNA = GDP + 5'-phospho-RNA. got7fsn_ti GTP-dependent polyribonucleotide kinase activity|GTP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity|GTP-dependent RNA kinase activity|GTP-dependent polynucleotide 5'-hydroxyl-kinase activity|GTP-dependent RNA 5'-hydroxyl-kinase activity molecular_function owl:Class
GO:0010150 biolink:NamedThing leaf senescence The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism. got7fsn_ti biological_process owl:Class
GO:0102523 biolink:NamedThing 2-chloroacrylate reductase activity Catalysis of the reaction: (S)-2-chloropropanoate + NADP <=> 2-chloroacrylate + NADPH + H+. got7fsn_ti EC:1.3.1.103|RHEA:36591|MetaCyc:RXN-14536 molecular_function owl:Class
GO:0099564 biolink:NamedThing modification of synaptic structure, modulating synaptic transmission Any process that modulates synaptic transmission via modification of the structure of the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0099563 biolink:NamedThing modification of synaptic structure Any process that modifies the structure/morphology of a synapse. got7fsn_ti synapse remodelling This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones. biological_process owl:Class
GO:0019769 biolink:NamedThing low-affinity IgE receptor activity Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti low affinity IgE receptor activity|low affinity Fc receptor activity molecular_function owl:Class
GO:0006837 biolink:NamedThing serotonin transport The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. got7fsn_ti biological_process owl:Class
GO:0052685 biolink:NamedThing perillic acid-CoA ligase (ADP-forming) activity Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP + phosphate + perillyl-CoA. got7fsn_ti perillic acid:CoA ligase (ADP-forming) activity|perillyl-CoA synthetase activity EC:6.2.1.-|KEGG_REACTION:R06367 molecular_function owl:Class
GO:0043122 biolink:NamedThing regulation of I-kappaB kinase/NF-kappaB signaling Any process that modulates I-kappaB kinase/NF-kappaB signaling. got7fsn_ti regulation of I-kappaB kinase/NF-kappaB cascade biological_process owl:Class
GO:0090675 biolink:NamedThing intermicrovillar adhesion The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin. got7fsn_ti tb 2016-02-19T13:34:07Z biological_process owl:Class
GO:0004823 biolink:NamedThing leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu). got7fsn_ti leucyl-transfer ribonucleate synthetase activity|leucine-tRNA synthetase activity|L-leucine:tRNALeu ligase (AMP-forming)|leucine translase activity|leucyl-tRNA synthetase activity|leucyl-transfer RNA synthetase activity|leucyl-transfer ribonucleic acid synthetase activity Reactome:R-HSA-380200|Reactome:R-HSA-379974|KEGG_REACTION:R03657|EC:6.1.1.4|RHEA:11688|MetaCyc:LEUCINE--TRNA-LIGASE-RXN molecular_function owl:Class
GO:0035994 biolink:NamedThing response to muscle stretch Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. got7fsn_ti bf 2011-08-30T01:52:31Z biological_process owl:Class
GO:0002349 biolink:NamedThing histamine production involved in inflammatory response The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti histamine production involved in acute inflammatory response biological_process owl:Class
GO:0034829 biolink:NamedThing 2-hydroxydec-2,4-diene-1,10-dioate hydratase activity Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate. got7fsn_ti UM-BBD_reactionID:r1172 molecular_function owl:Class
GO:0031267 biolink:NamedThing small GTPase binding Binding to a small monomeric GTPase. got7fsn_ti ADP-ribosylation factor binding|Ran protein binding|Ras interactor activity|Rab escort protein activity|Rab GTPase binding|Ran-binding protein|Rac GTPase binding|Rab interactor activity|ARF binding|GTP-Ral binding|Ran GTPase binding|Rho GTPase binding|Ral GTPase binding|GTP-Rho binding|REP|Ras GTPase binding https://github.com/geneontology/go-ontology/issues/18750 GO:0017048|GO:0005084|GO:0034989|GO:0048365|GO:0017031|GO:0017016|GO:0017160|GO:0008536|GO:0017049|GO:0030306|GO:0017137 molecular_function owl:Class
GO:0051020 biolink:NamedThing GTPase binding Binding to a GTPase, any enzyme that catalyzes the hydrolysis of GTP. got7fsn_ti molecular_function owl:Class
GO:0033189 biolink:NamedThing response to vitamin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus. got7fsn_ti response to retinol biological_process owl:Class
GO:0047884 biolink:NamedThing FAD diphosphatase activity Catalysis of the reaction: FAD + H2O = AMP + FMN. got7fsn_ti FAD pyrophosphatase activity|riboflavine adenine dinucleotide pyrophosphatase activity|FAD nucleotidohydrolase activity|riboflavin adenine dinucleotide pyrophosphatase activity|flavin adenine dinucleotide pyrophosphatase activity|flavine adenine dinucleotide pyrophosphatase activity|FAD pyrophosphohydrolase activity RHEA:13889|MetaCyc:FAD-PYROPHOSPHATASE-RXN|EC:3.6.1.18 molecular_function owl:Class
GO:0047424 biolink:NamedThing methylenediurea deaminase activity Catalysis of the reaction: 2 H2O + methylenediurea = CO2 + 2 NH3 + N-hydroxymethylurea. got7fsn_ti methylenediurea aminohydrolase activity|methylenediurease activity RHEA:15929|EC:3.5.3.21|MetaCyc:3.5.3.21-RXN molecular_function owl:Class
GO:0075214 biolink:NamedThing spore encystment The physiological, developmental and morphological changes that occur in a symbiont spore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti spore encystment on host biological_process owl:Class
GO:0006376 biolink:NamedThing mRNA splice site selection Selection of a splice site by components of the assembling spliceosome. got7fsn_ti spliceosomal E complex biosynthesis|spliceosomal E complex formation|spliceosomal commitment complex biosynthesis|spliceosomal commitment complex formation biological_process owl:Class
GO:0072539 biolink:NamedThing T-helper 17 cell differentiation The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 17 (Th17) cell. A Th17 cell is a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. got7fsn_ti T-helper 17 cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. mah 2011-01-17T11:18:47Z biological_process owl:Class
GO:0018764 biolink:NamedThing N-isopropylammelide isopropylaminohydrolase activity Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine. got7fsn_ti AtzC EC:3.5.4.42|MetaCyc:R123-RXN|UM-BBD_enzymeID:e0086|RHEA:23608 molecular_function owl:Class
GO:0019923 biolink:NamedThing alpha-1-microglobulin-chromophore linkage The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds. got7fsn_ti RESID:AA0224 biological_process owl:Class
GO:0043683 biolink:NamedThing type IV pilus assembly The assembly from its constituent parts of a type IV pilus. got7fsn_ti type IV fimbrial biogenesis|type IV fimbriae biogenesis|type IV fimbrial assembly|type IV fimbria biogenesis|type IV fimbria assembly|type IV pilus biogenesis|type IV fimbrium assembly|type IV fimbriae assembly|type IV fimbrium biogenesis https://github.com/geneontology/go-ontology/issues/14579 biological_process owl:Class
GO:0009297 biolink:NamedThing pilus assembly The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. got7fsn_ti fimbriae assembly|pilus biogenesis|fimbrial assembly|pilus formation|fimbrium assembly|fimbria biogenesis|fimbriae biogenesis|fimbrium biogenesis|fimbria assembly https://github.com/geneontology/go-ontology/issues/14579 biological_process owl:Class
GO:0023041 biolink:NamedThing neuronal signal transduction The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular. got7fsn_ti 2010-02-16T09:30:50Z biological_process owl:Class
GO:0036124 biolink:NamedThing histone H3-K9 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone. got7fsn_ti bf 2012-02-20T03:08:06Z biological_process owl:Class
GO:0072193 biolink:NamedThing ureter smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell in the ureter. got7fsn_ti mah 2010-03-01T01:55:01Z biological_process owl:Class
GO:0043097 biolink:NamedThing pyrimidine nucleoside salvage Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0006191 biolink:NamedThing deoxyinosine salvage Any process that generates deoxyinosine from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0036384 biolink:NamedThing cytidine-diphosphatase activity Catalysis of the reaction: CDP + H2O = CMP + phosphate. got7fsn_ti CDPase activity bf 2013-05-23T13:33:01Z RHEA:64880 molecular_function owl:Class
GO:0102273 biolink:NamedThing homophytochelatin synthase (dimmer forming) activity Catalysis of the reaction: glutathionate + L-gamma-glutamyl-L-cysteinyl-beta-alaninate <=> gamma-Glu-Cys-gamma-Glu-Cys-beta-Ala + glycine. got7fsn_ti MetaCyc:RXN-12529 molecular_function owl:Class
GO:0070843 biolink:NamedThing misfolded protein transport The directed movement of misfolded proteins in a cell, including the movement of proteins between specific compartments or structures within a cell. got7fsn_ti mah 2009-07-31T12:50:00Z biological_process owl:Class
GO:0071719 biolink:NamedThing sodium-independent leukotriene transport The directed, sodium-independent, movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups. got7fsn_ti mah 2010-03-10T03:08:42Z biological_process owl:Class
GO:0071716 biolink:NamedThing leukotriene transport The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups. got7fsn_ti mah 2010-03-10T02:53:59Z biological_process owl:Class
GO:0009597 biolink:NamedThing detection of virus The series of events in which a stimulus from a virus is received and converted into a molecular signal. got7fsn_ti perception of virus GO:0009597 is not a child term of 'detection of symbiont ; GO:0009602' to allow annotation of a virus responding to another (often competing) virus. biological_process owl:Class
GO:0009615 biolink:NamedThing response to virus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. got7fsn_ti response to viruses biological_process owl:Class
GO:0008431 biolink:NamedThing vitamin E binding Binding to a vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. got7fsn_ti tocopherol binding|alpha-tocopherol binding molecular_function owl:Class
GO:0021677 biolink:NamedThing rhombomere 8 formation The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:2000829 biolink:NamedThing negative regulation of parathyroid hormone secretion Any process that stops, prevents or reduces the frequency, rate or extent of parathyroid hormone secretion. got7fsn_ti negative regulation of parathormone secretion|negative regulation of PTH secretion|negative regulation of parathyrin secretion bf 2011-07-26T08:37:57Z biological_process owl:Class
GO:0015301 biolink:NamedThing anion:anion antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). got7fsn_ti anion exchanger activity|bicarbonate:chloride antiporter GO:0015380|GO:0015384 Reactome:R-HSA-561041 molecular_function owl:Class
GO:1990197 biolink:NamedThing methionine-importing ABC transporter complex An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner. got7fsn_ti MetNI complex|MetNIQ transport complex|MetNI transporter|MetNI transporter complex|methionine transporter complex, ATP-dependent|methionine transport complex|ATP-binding cassette (ABC) methionine importer complex|ATP-dependent methionine-importing complex|ATP-dependent methionine importer complex|MetNIQ transporter complex|methionine transporter|MetNI transport complex|ATP-dependent methionine importing complex|MetNIQ transporter|MetNIQ complex|methionine transporter complex https://github.com/geneontology/go-ontology/issues/21619 bhm 2013-09-26T09:38:26Z cellular_component owl:Class
GO:0032030 biolink:NamedThing myosin I light chain binding Binding to a light chain of a myosin I complex. got7fsn_ti molecular_function owl:Class
GO:0002279 biolink:NamedThing mast cell activation involved in immune response The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. got7fsn_ti mast cell activation during immune response biological_process owl:Class
GO:0001197 biolink:NamedThing positive regulation of mating-type specific transcription from RNA polymerase II promoter Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter. got7fsn_ti up regulation of transcription from an RNA polymerase II promoter, mating-type specific|up-regulation of transcription from an RNA polymerase II promoter, mating-type specific|activation of transcription from an RNA polymerase II promoter, mating-type specific|stimulation of transcription from an RNA polymerase II promoter, mating-type specific|upregulation of transcription from an RNA polymerase II promoter, mating-type specific krc 2011-11-23T09:31:33Z biological_process owl:Class
GO:0009638 biolink:NamedThing phototropism The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it. got7fsn_ti Wikipedia:Phototropism biological_process owl:Class
GO:0090329 biolink:NamedThing regulation of DNA-dependent DNA replication Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. got7fsn_ti tb 2010-05-14T10:42:04Z biological_process owl:Class
GO:0080127 biolink:NamedThing fruit septum development The process whose specific outcome is the progression of the fruit septum over time, from its formation to the mature structure. The fruit septum is a thin partition or membrane that divides a cavity or a mass of tissue in the fruit. got7fsn_ti dhl 2009-04-28T04:37:19Z biological_process owl:Class
GO:0097750 biolink:NamedThing endosome membrane tubulation A membrane tubulation process occurring in an endosome membrane. got7fsn_ti endosomal membrane tubulation pr 2016-12-21T12:33:09Z biological_process owl:Class
GO:0097749 biolink:NamedThing membrane tubulation A membrane organization process resulting in the formation of a tubular projection. This may face inwardly (as in tubular membrane invaginations) or outwardly (as in endosomal tubules). got7fsn_ti pr 2016-12-21T12:32:24Z biological_process owl:Class
GO:0009646 biolink:NamedThing response to absence of light Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli. got7fsn_ti response to darkness biological_process owl:Class
GO:0052572 biolink:NamedThing response to host immune response Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response to immune response of other organism involved in symbiotic interaction GO:0052564 biological_process owl:Class
GO:0010442 biolink:NamedThing guard cell morphogenesis Generation and organization of the polarized cell that is capable of turgor driven movement. got7fsn_ti guard cell morphogenesis during differentiation biological_process owl:Class
GO:0017013 biolink:NamedThing protein flavinylation The addition of a flavin group to a protein amino acid. got7fsn_ti protein amino acid flavinylation biological_process owl:Class
GO:1903706 biolink:NamedThing regulation of hemopoiesis Any process that modulates the frequency, rate or extent of hemopoiesis. got7fsn_ti regulation of hematopoiesis|regulation of haemopoiesis|regulation of blood cell formation|regulation of blood cell biosynthesis An example of this is Atg7 in mouse (UniProt symbol, Q9D906) in PMID:20080761, inferred from mutant phenotype. pad 2014-12-04T15:34:13Z biological_process owl:Class
GO:0008993 biolink:NamedThing rhamnulokinase activity Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate. got7fsn_ti L-rhamnulokinase activity|RhuK|ATP:L-rhamnulose 1-phosphotransferase activity|L-rhamnulose kinase activity|rhamnulose kinase activity|rhamnulokinase (phosphorylating) MetaCyc:RHAMNULOKIN-RXN|RHEA:20117|EC:2.7.1.5 molecular_function owl:Class
GO:1900551 biolink:NamedThing N',N'',N'''-triacetylfusarinine C biosynthetic process The chemical reactions and pathways resulting in the formation of N',N'',N'''-triacetylfusarinine C. got7fsn_ti N',N'',N'''-triacetylfusarinine C synthesis|N',N'',N'''-triacetylfusarinine C formation|N',N'',N'''-triacetylfusarinine C anabolism|N',N'',N'''-triacetylfusarinine C biosynthesis di 2012-05-15T01:00:58Z biological_process owl:Class
GO:0000016 biolink:NamedThing lactase activity Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. got7fsn_ti lactose galactohydrolase activity|lactase-phlorizin hydrolase activity EC:3.2.1.108|Reactome:R-HSA-5658001|Reactome:R-HSA-189062|RHEA:10076|MetaCyc:LACTASE-RXN molecular_function owl:Class
GO:0033244 biolink:NamedThing regulation of penicillin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. got7fsn_ti regulation of penicillin metabolism biological_process owl:Class
GO:0018857 biolink:NamedThing 2,4-dichlorobenzoate-CoA ligase activity Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA. got7fsn_ti UM-BBD_reactionID:r0137 molecular_function owl:Class
GO:0060009 biolink:NamedThing Sertoli cell development The process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate. got7fsn_ti biological_process owl:Class
GO:0003998 biolink:NamedThing acylphosphatase activity Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. got7fsn_ti acetic phosphatase activity|1,3-diphosphoglycerate phosphatase activity|acetylphosphatase activity|GP 1-3|Ho 1-3|acylphosphate phosphohydrolase activity RHEA:14965|EC:3.6.1.7|MetaCyc:ACYLPHOSPHATASE-RXN molecular_function owl:Class
GO:0008657 biolink:NamedThing DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. got7fsn_ti DNA gyrase inhibitor activity molecular_function owl:Class
GO:0030652 biolink:NamedThing peptide antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity. got7fsn_ti peptide antibiotic degradation|peptide antibiotic breakdown|peptide antibiotic catabolism biological_process owl:Class
GO:0045017 biolink:NamedThing glycerolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone. got7fsn_ti glycerolipid anabolism|glycerolipid formation|glycerolipid biosynthesis|glycerolipid synthesis biological_process owl:Class
GO:1990472 biolink:NamedThing piRNA dual-strand cluster binding Binding to dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription. got7fsn_ti An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay). bhm 2014-08-29T14:50:54Z molecular_function owl:Class
GO:1990470 biolink:NamedThing piRNA cluster binding Binding to piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs). got7fsn_ti An example of this is rhi in Drosophila melanogaster (Q7JXA8) in PMID:24906153 (inferred from direct assay). bhm 2014-08-29T14:23:38Z molecular_function owl:Class
GO:0019499 biolink:NamedThing cyanide metabolic process The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain. got7fsn_ti cyanide metabolism biological_process owl:Class
GO:0061534 biolink:NamedThing gamma-aminobutyric acid secretion, neurotransmission The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter. got7fsn_ti dph 2013-06-21T16:10:50Z biological_process owl:Class
GO:0047813 biolink:NamedThing D-arabinitol 4-dehydrogenase activity Catalysis of the reaction: D-arabinitol + NAD+ = D-xylulose + NADH. got7fsn_ti MetaCyc:D-ARABINITOL-4-DEHYDROGENASE-RXN|EC:1.1.1.11|RHEA:17921 molecular_function owl:Class
GO:0004059 biolink:NamedThing aralkylamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine. got7fsn_ti arylalkylamine N-acetyltransferase activity|acetyl-CoA:2-arylethylamine N-acetyltransferase activity|AANAT activity|melatonin rhythm enzyme activity|serotonin N-acetyltransferase activity|serotonin acetyltransferase activity|serotonin acetylase activity RHEA:20497|EC:2.3.1.87|MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN|Reactome:R-HSA-209792 molecular_function owl:Class
GO:0060309 biolink:NamedThing elastin catabolic process The chemical reactions and pathways resulting in the breakdown of elastin. Elastin is a glycoprotein which is randomly coiled and crosslinked to form elastic fibers that are found in connective tissue. got7fsn_ti elastin catabolism|elastin degradation|elastin breakdown biological_process owl:Class
GO:0098810 biolink:NamedThing neurotransmitter reuptake The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol. got7fsn_ti biological_process owl:Class
GO:0034820 biolink:NamedThing 4,9-DSHA hydrolase activity Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+. got7fsn_ti UM-BBD_reactionID:r1152 molecular_function owl:Class
GO:0008756 biolink:NamedThing o-succinylbenzoate-CoA ligase activity Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate. got7fsn_ti o-succinylbenzoyl-CoA synthetase activity|o-succinylbenzoate:CoA ligase (AMP-forming)|2-succinylbenzoate:CoA ligase (AMP-forming)|o-succinylbenzoyl-coenzyme A synthetase activity|OSB-CoA synthetase activity KEGG_REACTION:R04030|EC:6.2.1.26|RHEA:17009|MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN molecular_function owl:Class
GO:0000279 biolink:NamedThing M phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase. got7fsn_ti M-phase Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:M_phase biological_process owl:Class
GO:0039618 biolink:NamedThing T=pseudo3 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres. got7fsn_ti T=pseudo3 capsids are not T=3 symmetry as described by Caspar and Klug (PMID:14019094) because the basic unit is composed of three different proteins. Since the three subunits are morphologically very similar, the structure is therefore a pseudo T=3. bf 2012-07-18T02:10:02Z VZ:809 cellular_component owl:Class
GO:0005243 biolink:NamedThing gap junction channel activity A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. got7fsn_ti intercellular channel|connexin|innexin channel activity|innexin GO:0015285|GO:0015286 Reactome:R-HSA-375340|Reactome:R-HSA-375342|Reactome:R-HSA-375339|Reactome:R-HSA-190681|Reactome:R-HSA-375330 molecular_function owl:Class
GO:0022829 biolink:NamedThing wide pore channel activity Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. got7fsn_ti non-gated, wide pore channel activity|gap junction activity molecular_function owl:Class
GO:1900160 biolink:NamedThing plastid DNA packaging Any process in which plastidial DNA and associated proteins are formed into a compact, orderly structure. got7fsn_ti DNA organisation in plastid|DNA organization in plastid|plastidial DNA packaging bf 2012-03-08T10:51:50Z biological_process owl:Class
GO:0044878 biolink:NamedThing mitotic cytokinesis checkpoint signaling A signaling process that contributes to a mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed. got7fsn_ti mitotic cytokinesis checkpoint|signaling pathway involved in mitotic cytokinesis checkpoint|cytokinesis after mitosis checkpoint|defective cytokinesis checkpoint|signal transduction involved in mitotic cytokinesis checkpoint|signalling cascade involved in mitotic cytokinesis checkpoint|signalling pathway involved in mitotic cytokinesis checkpoint https://github.com/geneontology/go-ontology/issues/20935 jl 2015-01-13T15:30:23Z GO:1903820 biological_process owl:Class
GO:0035970 biolink:NamedThing peptidyl-threonine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine. got7fsn_ti bf 2011-08-08T02:57:11Z biological_process owl:Class
GO:0005996 biolink:NamedThing monosaccharide metabolic process The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. got7fsn_ti monosaccharide metabolism biological_process owl:Class
GO:0072670 biolink:NamedThing mitochondrial tRNA threonylcarbamoyladenosine modification The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in mitochondrial tRNAs that decode ANN codons (where N is any base). got7fsn_ti mitochondrial tRNA t6A modification mah 2011-02-18T11:34:35Z biological_process owl:Class
GO:0043608 biolink:NamedThing formamide catabolic process The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid. got7fsn_ti biological_process owl:Class
GO:0060175 biolink:NamedThing brain-derived neurotrophic factor-activated receptor activity Combining with a brain-derived neurotrophic factor and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti brain-derived neurotrophic factor receptor activity|BDNF-activated receptor activity|BDNF receptor activity Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand BDNF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. molecular_function owl:Class
GO:1990811 biolink:NamedThing MWP complex A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin. got7fsn_ti Msd1-Wdr8-Pkl1 complex vw 2015-07-24T13:34:31Z cellular_component owl:Class
GO:0018114 biolink:NamedThing threonine racemase activity Catalysis of the reaction: L-threonine = D-threonine. got7fsn_ti EC:5.1.1.6|MetaCyc:THREONINE-RACEMASE-RXN|RHEA:13913|KEGG_REACTION:R01467 molecular_function owl:Class
GO:0050228 biolink:NamedThing pterin deaminase activity Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3. got7fsn_ti acrasinase activity|2-amino-4-hydroxypteridine aminohydrolase activity RHEA:11904|MetaCyc:PTERIN-DEAMINASE-RXN|EC:3.5.4.11 molecular_function owl:Class
GO:0060118 biolink:NamedThing vestibular receptor cell development The process whose specific outcome is the progression of a vestibular receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti vestibular hair cell development biological_process owl:Class
GO:0070169 biolink:NamedThing positive regulation of biomineral tissue development Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds. got7fsn_ti biological_process owl:Class
GO:0007078 biolink:NamedThing lamin depolymerization The cell cycle process in which lamin is depolymerized. got7fsn_ti biological_process owl:Class
GO:0015250 biolink:NamedThing water channel activity Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti aquaporin Reactome:R-HSA-507870|Reactome:R-HSA-507868|Reactome:R-HSA-432065|Reactome:R-HSA-432054|Reactome:R-HSA-432067|Reactome:R-HSA-445714|RHEA:29667|Reactome:R-HSA-432010 molecular_function owl:Class
GO:0009945 biolink:NamedThing radial axis specification The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point. got7fsn_ti biological_process owl:Class
GO:0034515 biolink:NamedThing proteasome storage granule An aggregation of proteasome core protease (CP) and regulatory particle (RP) complexes that localizes in the cytoplasm as dot-like structures when cells are in a quiescent state. got7fsn_ti PSG https://github.com/geneontology/go-ontology/issues/20297 cellular_component owl:Class
GO:0004358 biolink:NamedThing glutamate N-acetyltransferase activity Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine. got7fsn_ti ornithine acetyltransferase activity|acetylglutamic-acetylornithine transacetylase activity|N-acetylglutamate synthetase activity|acetylglutamic synthetase activity|glutamate acetyltransferase activity|alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity|2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity|acetylornithine glutamate acetyltransferase activity|N-acetyl-L-glutamate synthetase activity|ornithine transacetylase activity|acetylglutamate synthetase activity|acetylglutamate-acetylornithine transacetylase activity|N-acetylglutamate synthase activity|N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity|acetylornithinase activity KEGG_REACTION:R02282|RHEA:15349|MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN|EC:2.3.1.35 molecular_function owl:Class
GO:0106266 biolink:NamedThing 3-chloro THPH synthase activity Catalysis of the reaction: 2,4,6-trihydroxyphenylhexan-1-one + chloride + FADH2 + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + H+ + 2 H2O. got7fsn_ti hjd 2020-06-02T18:13:44Z RHEA:64356 molecular_function owl:Class
GO:0018316 biolink:NamedThing peptide cross-linking via L-cystine The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain. got7fsn_ti RESID:AA0025 biological_process owl:Class
GO:0046344 biolink:NamedThing ecdysteroid catabolic process The chemical reactions and pathways resulting in the breakdown of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development. got7fsn_ti ecdysteroid degradation|ecdysteroid catabolism|ecdysteroid breakdown biological_process owl:Class
GO:0042182 biolink:NamedThing ketone catabolic process The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. got7fsn_ti ketone breakdown|ketone degradation|ketone catabolism biological_process owl:Class
GO:0003226 biolink:NamedThing right ventricular compact myocardium morphogenesis The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized. got7fsn_ti dph 2009-10-13T10:48:42Z biological_process owl:Class
GO:0042439 biolink:NamedThing ethanolamine-containing compound metabolic process The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. got7fsn_ti ethanolamine-containing compound metabolism|ethanolamine and derivative metabolic process|ethanolamine and derivative metabolism biological_process owl:Class
GO:0031713 biolink:NamedThing B2 bradykinin receptor binding Binding to a B2 bradykinin receptor. got7fsn_ti B2 bradykinin receptor ligand molecular_function owl:Class
GO:0060059 biolink:NamedThing embryonic retina morphogenesis in camera-type eye The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage. got7fsn_ti biological_process owl:Class
GO:0008705 biolink:NamedThing methionine synthase activity Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine. got7fsn_ti N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity|cobalamin-dependent methionine synthase activity|methionine synthase (cobalamin-dependent) activity|B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity|N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity|tetrahydropteroylglutamic methyltransferase activity|5-methyltetrahydrofolate--homocysteine transmethylase activity|tetrahydrofolate methyltransferase activity|N5-methyltetrahydrofolate methyltransferase activity|5-methyltetrahydrofolate--homocysteine S-methyltransferase activity|N(5)-methyltetrahydrofolate methyltransferase activity|tetrahydropteroylglutamate methyltransferase activity|vitamin B12 methyltransferase activity|methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity|B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity|N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity|5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity|N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity|MetH|5-methyltetrahydrofolate-homocysteine S-methyltransferase activity|N-methyltetrahydrofolate:L-homocysteine methyltransferase activity Reactome:R-HSA-3149539|KEGG_REACTION:R00946|RHEA:11172|EC:2.1.1.13|Reactome:R-HSA-174374|MetaCyc:HOMOCYSMETB12-RXN molecular_function owl:Class
GO:0047625 biolink:NamedThing adenosylmethionine cyclotransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone. got7fsn_ti S-adenosyl-L-methionine alkyltransferase (cyclizing)|adenosyl methionine cyclotransferase activity|adenosylmethioninase activity KEGG_REACTION:R00180|MetaCyc:ADENOSYLMETHIONINE-CYCLOTRANSFERASE-RXN|EC:2.5.1.4|RHEA:21932 molecular_function owl:Class
GO:0042450 biolink:NamedThing arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. got7fsn_ti arginine anabolism via ornithine|arginine synthesis via ornithine|arginine formation via ornithine biological_process owl:Class
GO:0006591 biolink:NamedThing ornithine metabolic process The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. got7fsn_ti ornithine metabolism biological_process owl:Class
GO:0051632 biolink:NamedThing negative regulation of acetylcholine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of acetylcholine into a cell. got7fsn_ti downregulation of acetylcholine uptake|down regulation of acetylcholine uptake|down-regulation of acetylcholine uptake|negative regulation of acetylcholine import biological_process owl:Class
GO:0051953 biolink:NamedThing negative regulation of amine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti inhibition of amine transport|down regulation of amine transport|downregulation of amine transport|down-regulation of amine transport biological_process owl:Class
GO:0016432 biolink:NamedThing tRNA-uridine aminocarboxypropyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine. got7fsn_ti S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity EC:2.5.1.25|RHEA:12300|MetaCyc:2.5.1.25-RXN molecular_function owl:Class
GO:0090721 biolink:NamedThing primary adaptive immune response involving T cells and B cells An adaptive immune response mediated by naive T or B cells against an antigen not previously encountered by immune system. got7fsn_ti tb 2016-11-11T12:46:29Z biological_process owl:Class
GO:0090720 biolink:NamedThing primary adaptive immune response An adaptive immune response against an antigen not previously encountered by immune system. got7fsn_ti tb 2016-11-11T12:44:55Z biological_process owl:Class
GO:0033588 biolink:NamedThing elongator holoenzyme complex A heterohexameric protein complex composed two discrete heterotrimeric subcomplexes that is involved in modification of wobble nucleosides in tRNA. got7fsn_ti Elongator core complex|Elongator holoenzyme complex https://github.com/geneontology/go-ontology/issues/22076 Despite its name, this complex is not directly involved in transcriptional elongation (PMID:23165209). GO:0033589 cellular_component owl:Class
GO:0050108 biolink:NamedThing monoterpenyl-diphosphatase activity Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate. got7fsn_ti monoterpenyl-diphosphate diphosphohydrolase activity|monoterpenyl-pyrophosphatase activity|bornyl pyrophosphate hydrolase activity|bornyl diphosphate hydrolase activity EC:3.1.7.3|MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN molecular_function owl:Class
GO:0047168 biolink:NamedThing isocitrate O-dihydroxycinnamoyltransferase activity Catalysis of the reaction: caffeoyl-CoA + isocitrate = 2-caffeoylisocitrate + CoA. got7fsn_ti caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase activity RHEA:20756|KEGG_REACTION:R01946|EC:2.3.1.126|MetaCyc:2.3.1.126-RXN molecular_function owl:Class
GO:0050106 biolink:NamedThing monomethyl-sulfatase activity Catalysis of the reaction: H(2)O + monomethyl sulfate = H(+) + methanol + sulfate. got7fsn_ti monomethyl-sulphatase activity|monomethyl-sulfate sulfohydrolase activity KEGG_REACTION:R01145|RHEA:14221|EC:3.1.6.16|MetaCyc:MONOMETHYL-SULFATASE-RXN molecular_function owl:Class
GO:0008976 biolink:NamedThing polyphosphate kinase activity Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). got7fsn_ti polyphosphoric acid kinase activity|ATP:polyphosphate phosphotransferase activity|ATP-polyphosphate phosphotransferase activity|polyphosphate polymerase activity RHEA:19573|MetaCyc:POLYPHOSPHATE-KINASE-RXN|EC:2.7.4.1 molecular_function owl:Class
GO:0003298 biolink:NamedThing physiological muscle hypertrophy The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development. got7fsn_ti dph 2009-10-22T09:24:51Z biological_process owl:Class
GO:0006925 biolink:NamedThing inflammatory cell apoptotic process Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage. got7fsn_ti killing of inflammatory cells|programmed cell death, inflammatory cells|inflammatory cell apoptosis|inflammatory cell programmed cell death by apoptosis|programmed cell death of inflammatory cells by apoptosis|apoptosis of inflammatory cells biological_process owl:Class
GO:0033229 biolink:NamedThing cysteine transmembrane transporter activity Enables the transfer of cysteine from one side of a membrane to the other. got7fsn_ti https://github.com/geneontology/go-ontology/issues/17289 RHEA:32795 molecular_function owl:Class
GO:0050134 biolink:NamedThing N6-methyl-lysine oxidase activity Catalysis of the reaction: N(6)-methyl-L-lysine + H(2)O + O(2) = L-lysine + formaldehyde + H(2)O(2). got7fsn_ti 6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating)|epsilon-alkyllysinase activity|N6-methyl-L-lysine:oxygen oxidoreductase (demethylating)|epsilon-N-methyllysine demethylase activity|N(6)-methyllysine oxidase activity|epsilon-alkyl-L-lysine:oxygen oxidoreductase activity|N6-methyllysine oxidase activity MetaCyc:N6-METHYL-LYSINE-OXIDASE-RXN|RHEA:23200|EC:1.5.3.4|KEGG_REACTION:R00612 molecular_function owl:Class
GO:0050117 biolink:NamedThing N-acetyl-beta-alanine deacetylase activity Catalysis of the reaction: N-acetyl-beta-alanine + H(2)O = beta-alanine + acetate. got7fsn_ti N-acetyl-beta-alanine amidohydrolase activity MetaCyc:N-ACETYL-BETA-ALANINE-DEACETYLASE-RXN|KEGG_REACTION:R00909|RHEA:23212|EC:3.5.1.21 molecular_function owl:Class
GO:1900796 biolink:NamedThing terrequinone A biosynthetic process The chemical reactions and pathways resulting in the formation of terrequinone A. got7fsn_ti terrequinone A biosynthesis|terrequinone A anabolism|terrequinone A synthesis|terrequinone A formation di 2012-06-04T09:45:48Z biological_process owl:Class
GO:0002443 biolink:NamedThing leukocyte mediated immunity Any process involved in the carrying out of an immune response by a leukocyte. got7fsn_ti leukocyte immune effector process|leucocyte mediated immunity|cellular immune response|immune cell mediated immunity|immune cell effector process|leucocyte immune effector process|cell-mediated immune response GO:0019723|GO:0042087 biological_process owl:Class
GO:0061969 biolink:NamedThing maintenance of left sidedness The organization process that preserves the left sidedness in an organism's body plan or part of an organism with respect to the left and right halves. got7fsn_ti dph 2018-02-12T16:41:30Z biological_process owl:Class
GO:0032577 biolink:NamedThing phosphatidylcholine:cardiolipin O-linoleoyltransferase activity Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule. got7fsn_ti phosphatidylcholine:cardiolipin linoleoyltransferase molecular_function owl:Class
GO:0032576 biolink:NamedThing O-linoleoyltransferase activity Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0044760 biolink:NamedThing modulation by symbiont of host cholinergic synaptic transmission Any process in which a symbiont organism modulates the frequency, rate or extent of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism. got7fsn_ti regulation by symbiont of host cholinergic synaptic transmission jl 2012-12-06T15:39:46Z biological_process owl:Class
GO:0044758 biolink:NamedThing modulation by symbiont of host synaptic transmission Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism. got7fsn_ti regulation by symbiont of host synaptic transmission jl 2012-12-06T15:34:05Z biological_process owl:Class
GO:0018390 biolink:NamedThing peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester. got7fsn_ti peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine|peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine|peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine RESID:AA0072 biological_process owl:Class
GO:0021947 biolink:NamedThing outward migration of deep nuclear neurons The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate. got7fsn_ti biological_process owl:Class
GO:1990340 biolink:NamedThing laminin-15 complex A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains. got7fsn_ti laminin-523 bhm 2014-03-20T23:48:25Z cellular_component owl:Class
GO:0010295 biolink:NamedThing (+)-abscisic acid 8'-hydroxylase activity Catalysis of the reaction: (+)-abscisate + H(+) + NADPH + O(2) = (+)-8'-hydroxyabscisate + H(2)O + NADP(+). got7fsn_ti abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)|ABA 8'-hydroxylase activity|abscisic acid 8'-hydroxylase activity|ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity|(+)-ABA 8'-hydroxylase activity MetaCyc:1.14.13.93-RXN|RHEA:12897|KEGG_REACTION:R07202|EC:1.14.14.137 molecular_function owl:Class
GO:0061834 biolink:NamedThing actin filament branch point The part of an actin filament where the structure forks. got7fsn_ti microfilament branch point cellular_component owl:Class
GO:0030798 biolink:NamedThing trans-aconitate 2-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine. got7fsn_ti S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity KEGG_REACTION:R05763|EC:2.1.1.144|MetaCyc:RXN0-2441|RHEA:14969 molecular_function owl:Class
GO:0036338 biolink:NamedThing viral membrane The lipid bilayer of a virion, a complete fully infectious extracellular virus particle. got7fsn_ti bf 2012-09-07T13:28:21Z cellular_component owl:Class
GO:0102274 biolink:NamedThing glutathione S-conjugate carboxypeptidase activity Catalysis of the reaction: H2O + a glutathione-toxin conjugate <=> glycine + a [Glu-Cys]-S-conjugate. got7fsn_ti MetaCyc:RXN-12532 molecular_function owl:Class
GO:0047874 biolink:NamedThing dolichyldiphosphatase activity Catalysis of the reaction: dolichyl diphosphate + H2O = dolichyl phosphate + phosphate. got7fsn_ti dolichyl pyrophosphatase activity|dolichyl diphosphate phosphohydrolase activity|dolichol diphosphatase activity|dolichyl-diphosphate phosphohydrolase activity MetaCyc:DOLICHYLDIPHOSPHATASE-RXN|EC:3.6.1.43|Reactome:R-HSA-446200|RHEA:14385 molecular_function owl:Class
GO:0017190 biolink:NamedThing N-terminal peptidyl-aspartic acid acetylation The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase. got7fsn_ti See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. RESID:AA0042 biological_process owl:Class
GO:0001757 biolink:NamedThing somite specification The process in which individual somites establish identity during embryogenesis. got7fsn_ti biological_process owl:Class
GO:0032005 biolink:NamedThing signal transduction involved in positive regulation of conjugation with cellular fusion The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion. got7fsn_ti biological_process owl:Class
GO:0055039 biolink:NamedThing trichocyst A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in net-like structures, to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft. got7fsn_ti Wikipedia:Trichocyst cellular_component owl:Class
GO:0047671 biolink:NamedThing anthranilate adenylyltransferase activity Catalysis of the reaction: anthranilate + ATP = N-adenylylanthranilate + diphosphate + H(+). got7fsn_ti ATP:anthranilate adenylyltransferase activity|ATP:anthranilate N-adenylyltransferase activity|anthranilic acid adenylyltransferase activity MetaCyc:ANTHRANILATE-ADENYLYLTRANSFERASE-RXN|RHEA:22412|EC:2.7.7.55|KEGG_REACTION:R00979 molecular_function owl:Class
GO:0072675 biolink:NamedThing osteoclast fusion The plasma membrane fusion process that results in fusion of mononuclear osteoclasts to form a multinuclear osteoclast. got7fsn_ti mah 2011-02-22T02:14:34Z biological_process owl:Class
GO:0052722 biolink:NamedThing fatty acid in-chain hydroxylase activity Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O. got7fsn_ti ai 2011-08-15T01:41:07Z MetaCyc:RXN-12186|RHEA:45084 molecular_function owl:Class
GO:0019060 biolink:NamedThing intracellular transport of viral protein in host cell The directed movement of a viral protein within the host cell. got7fsn_ti intracellular viral capsid transport|intracellular transport of viral capsid in host cell|intracellular viral protein transport|viral capsid transport in host cell cytoplasm|viral capsid transport in host cell nucleus|nuclear viral capsid transport|cytoplasmic viral capsid transport|intracellular transport of viral capsid protein in host cell|intracellular transport of viral proteins in host cell This term is for annotation of proteins responsible for the movement of individual viral proteins, rather than the whole viral particle. GO:0046801|GO:0046743|GO:0046742 biological_process owl:Class
GO:0043749 biolink:NamedThing phenol, water dikinase activity Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate. got7fsn_ti phenylphosphate synthase activity|phenol:water dikinase activity|ATP:phenol:water phosphotransferase activity EC:2.7.9.- molecular_function owl:Class
GO:0086093 biolink:NamedThing G protein-coupled acetylcholine receptor signaling pathway involved in heart process A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart. got7fsn_ti muscarinic receptor signaling pathway involved in heart process|G-protein coupled acetylcholine receptor signaling pathway involved in heart process|M2 receptor signaling pathway involved in heart process|G-protein coupled acetylcholine receptor signalling pathway involved in heart process bf biological_process owl:Class
GO:0031904 biolink:NamedThing endosome lumen The volume enclosed by the membrane of an endosome. got7fsn_ti NIF_Subcellular:sao1547508851 cellular_component owl:Class
GO:0006305 biolink:NamedThing DNA alkylation The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. got7fsn_ti biological_process owl:Class
GO:0010249 biolink:NamedThing auxin conjugate metabolic process The chemical reactions and pathways involving auxin conjugates, a bound form of auxin. got7fsn_ti auxin conjugate metabolism biological_process owl:Class
GO:0000031 biolink:NamedThing mannosylphosphate transferase activity Catalysis of the transfer of a mannosylphosphate group from one compound to another. got7fsn_ti molecular_function owl:Class
GO:0090678 biolink:NamedThing cell dedifferentiation involved in phenotypic switching A cell dedifferentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. got7fsn_ti tb 2016-04-28T17:32:40Z biological_process owl:Class
GO:0060266 biolink:NamedThing negative regulation of respiratory burst involved in inflammatory response Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. got7fsn_ti negative regulation of respiratory burst involved in acute inflammatory response biological_process owl:Class
GO:0017044 biolink:NamedThing melanocyte-stimulating hormone activity The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates. got7fsn_ti alpha-melanophore stimulating hormone activity|melanocyte stimulating hormone activity|alpha-melanocyte stimulating hormone activity molecular_function owl:Class
GO:0061661 biolink:NamedThing FAT10 ligase activity Catalysis of the transfer of FAT10 to a substrate protein via the reaction X-FAT10 + S --> X + S-FAT10, where X is either an E2 or E3 enzyme, the X-FAT10 linkage is a thioester bond, and the S-FAT10 linkage is an isopeptide bond between the C-terminal glycine of FAT10 and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T13:53:10Z molecular_function owl:Class
GO:0019775 biolink:NamedThing FAT10 transferase activity Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y --> Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages. got7fsn_ti FAT10 conjugating enzyme activity molecular_function owl:Class
GO:0045133 biolink:NamedThing 2,3-dihydroxybenzoate 3,4-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). got7fsn_ti 2,3-dihydroxybenzoate oxygenase activity|o-pyrocatechuate oxygenase activity|2,3-dihydroxybenzoate 1,2-dioxygenase activity|2,3-dihydroxybenzoate:oxygen 3,4-oxidoreductase (decyclizing)|2,3-dihydroxybenzoic oxygenase activity RHEA:18477|EC:1.13.11.14|KEGG_REACTION:R01507|MetaCyc:1.13.11.14-RXN molecular_function owl:Class
GO:0047762 biolink:NamedThing caffeate 3,4-dioxygenase activity Catalysis of the reaction: trans-caffeate + O(2) = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+). got7fsn_ti 3,4-dihydroxy-trans-cinnamate:oxygen 3,4-oxidoreductase (decyclizing) MetaCyc:CAFFEATE-34-DIOXYGENASE-RXN|EC:1.13.11.22|KEGG_REACTION:R03365|RHEA:22216 molecular_function owl:Class
GO:0071944 biolink:NamedThing cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures. got7fsn_ti mah 2010-10-04T01:51:47Z cellular_component owl:Class
GO:0044572 biolink:NamedThing [4Fe-4S] cluster assembly The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster. got7fsn_ti 4Fe-4S cluster assembly|[4Fe-4S] cluster biosynthetic process jl 2012-04-18T03:19:23Z biological_process owl:Class
GO:0047064 biolink:NamedThing sulochrin oxidase [(+)-bisdechlorogeodin-forming] activity Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H(2)O. got7fsn_ti sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)|sulochrin oxidase activity RHEA:24092|MetaCyc:1.10.3.7-RXN|EC:1.21.3.4|KEGG_REACTION:R00060 molecular_function owl:Class
GO:0001637 biolink:NamedThing G protein-coupled chemoattractant receptor activity Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G-protein chemoattractant receptor activity|G-protein coupled chemoattractant receptor activity|G protein chemoattractant receptor activity molecular_function owl:Class
GO:0001995 biolink:NamedThing norepinephrine-epinephrine catabolic process in blood stream The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream. got7fsn_ti noradrenaline-adrenalin catabolic process in blood stream biological_process owl:Class
GO:0042419 biolink:NamedThing epinephrine catabolic process The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. got7fsn_ti epinephrine breakdown|epinephrine catabolism|adrenaline catabolism|epinephrine degradation|adrenaline catabolic process biological_process owl:Class
GO:0044295 biolink:NamedThing axonal growth cone The migrating motile tip of a growing nerve cell axon. got7fsn_ti axon growth cone jl 2010-02-04T03:57:16Z NIF_Subcellular:sao1594955670|NIF_Subcellular:sao203987954 cellular_component owl:Class
GO:0047682 biolink:NamedThing aryl-alcohol oxidase activity Catalysis of the reaction: an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2. got7fsn_ti veratryl alcohol oxidase activity|aryl alcohol oxidase activity|aryl-alcohol:oxygen oxidoreductase activity|arom. alcohol oxidase activity MetaCyc:ARYL-ALCOHOL-OXIDASE-RXN|RHEA:17541|EC:1.1.3.7 molecular_function owl:Class
GO:1990029 biolink:NamedThing vasomotion The rhythmical contraction and relaxation of arterioles, observed as slow and fast waves, with frequencies of 1-2 and 10-20 cpm. got7fsn_ti tb 2013-02-06T22:30:21Z biological_process owl:Class
GO:0001042 biolink:NamedThing RNA polymerase I core binding Binding to a RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits. got7fsn_ti krc 2010-09-23T01:39:23Z molecular_function owl:Class
GO:0090617 biolink:NamedThing mitochondrial mRNA 5'-end processing Any process involved in forming the mature 5' end of an mRNA molecule that derives from the mitochondrial genome. got7fsn_ti tb 2014-10-24T12:45:08Z biological_process owl:Class
GO:0120323 biolink:NamedThing lipid ubiquitination The process in which one or more ubiquitin groups are added to a lipid. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21857 krc 2021-07-20T18:58:34Z biological_process owl:Class
GO:0120322 biolink:NamedThing lipid modification by small protein conjugation A lipid modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target lipid. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21857 krc 2021-07-20T18:53:03Z biological_process owl:Class
GO:0033976 biolink:NamedThing 2-haloacid dehalogenase (configuration-inverting) activity Catalysis of the reactions: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide. got7fsn_ti 2-haloalkanoic acid dehalogenase activity|DL-DEXi|DL-2-haloacid halidohydrolase (inversion of configuration) activity|DL-2-haloacid dehalogenase activity|DL-2-haloacid dehalogenase (inversion of configuration) activity|2-haloalkanoid acid halidohydrolase activity MetaCyc:3.8.1.10-RXN molecular_function owl:Class
GO:0018634 biolink:NamedThing alpha-pinene monooxygenase [NADH] activity Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide. got7fsn_ti UM-BBD_reactionID:r0742|EC:1.14.13.- molecular_function owl:Class
GO:0097473 biolink:NamedThing retinal rod cell apoptotic process Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina. got7fsn_ti rod photoreceptor apoptotic process pr 2013-03-21T09:44:45Z biological_process owl:Class
GO:1990009 biolink:NamedThing retinal cell apoptotic process Any apoptotic process in a retinal cell. got7fsn_ti induction of retinal programmed cell death pr 2012-12-12T10:15:08Z GO:0046674 biological_process owl:Class
GO:0034684 biolink:NamedThing integrin alphav-beta5 complex An integrin complex that comprises one alphav subunit and one beta5 subunit. got7fsn_ti alphav-beta5 integrin complex|ITGAV-ITGB5 complex cellular_component owl:Class
GO:0061543 biolink:NamedThing 3-demethylubiquinol-6 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-6 = S-adenosyl-L-homocysteine + ubiquinol-6. got7fsn_ti dph 2013-06-25T08:05:14Z molecular_function owl:Class
GO:0106094 biolink:NamedThing nuclear membrane microtubule tethering complex A nuclear membrane protein complex which connects the nuclear outer and inner membranes together, and links thereby links the nuclear lumen to cytoplasmic microtubules. got7fsn_ti nuclear membrane microtubule tethering complex hjd 2018-02-02T18:58:35Z cellular_component owl:Class
GO:0106083 biolink:NamedThing nuclear membrane protein complex Any protein complex that is part of the nuclear membrane. got7fsn_ti hjd 2018-01-05T19:51:26Z cellular_component owl:Class
GO:0050248 biolink:NamedThing Renilla-luciferin 2-monooxygenase activity Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light. got7fsn_ti Renilla-type luciferase activity|aequorin activity|luciferase activity|Renilla-luciferin:oxygen 2-oxidoreductase (decarboxylating)|luciferase (Renilla luciferin) MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN|RHEA:14765|EC:1.13.12.5 molecular_function owl:Class
GO:0033999 biolink:NamedThing chondroitin B lyase activity Catalysis of the reaction: dermatan sulfate = n 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate. This reaction is the eliminative cleavage of dermatan sulfate containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucurosonyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (DeltaUA-GalNAC-4S). Chondroitin sulfate B is also known as dermatan sulfate. got7fsn_ti ChnB|chonB|chondroitinase B activity|dermatan sulfate lyase activity MetaCyc:4.2.2.19-RXN|EC:4.2.2.19 molecular_function owl:Class
GO:0060420 biolink:NamedThing regulation of heart growth Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. got7fsn_ti biological_process owl:Class
GO:0003072 biolink:NamedThing renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature. got7fsn_ti renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence|regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence biological_process owl:Class
GO:0036416 biolink:NamedThing tRNA stabilization Prevention of degradation of tRNA molecules. got7fsn_ti bf 2013-08-22T15:41:26Z biological_process owl:Class
GO:0036415 biolink:NamedThing regulation of tRNA stability Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs. got7fsn_ti bf 2013-08-22T15:22:13Z biological_process owl:Class
GO:0052799 biolink:NamedThing coenzyme F420-dependent bicyclic nitroimidazole catabolic process The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates. got7fsn_ti coenzyme F420-dependent nitroimidazole catabolism|coenzyme F420-dependent nitroimidazole reduction|coenzyme F420-dependent nitroreductase activity|coenzyme F420-dependent nitroimidazole breakdown biological_process owl:Class
GO:0009227 biolink:NamedThing nucleotide-sugar catabolic process The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. got7fsn_ti nucleotide-sugar breakdown|nucleotide-sugar catabolism|nucleotide-sugar degradation biological_process owl:Class
GO:0061069 biolink:NamedThing male urethra development The progression of the male urethra over time from its initial formation to the mature structure. The male urethra is a renal system organ that carries urine from the bladder through the penis to outside the body. got7fsn_ti dph 2010-03-12T08:28:19Z biological_process owl:Class
GO:0085034 biolink:NamedThing suppression by symbiont of host I-kappaB kinase/NF-kappaB cascade Any process that stops, prevents, or reduces the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade jl 2010-07-27T03:32:44Z biological_process owl:Class
GO:0039552 biolink:NamedThing RIG-I binding Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA. got7fsn_ti DDX58 binding|DDX58/RIG-I binding bf 2012-01-19T02:14:20Z molecular_function owl:Class
GO:0033546 biolink:NamedThing myo-inositol hexakisphosphate biosynthetic process, via inositol 1,3,4-trisphosphate The chemical reactions and pathways resulting in the formation of 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate, phytate, by a pathway using inositol 1,4,5-trisphosphate produced from phosphatidylinositol 4,5-biphosphate hydrolysis by phospholipase C; in this pathway, inositol 1,4,5-trisphosphate is first converted to inositol 1,3,4-trisphosphate, and then phosphorylated further. got7fsn_ti phytate biosynthesis, via inositol 1,3,4-trisphosphate|phytate biosynthetic process, via inositol 1,3,4-trisphosphate|myo-inositol hexakisphosphate biosynthesis, via inositol 1,3,4-trisphosphate|myo-inositol hexakisphosphate synthesis, via inositol 1,3,4-trisphosphate|myo-inositol hexakisphosphate formation, via inositol 1,3,4-trisphosphate|myo-inositol hexakisphosphate anabolism, via inositol 1,3,4-trisphosphate MetaCyc:PWY-6554 biological_process owl:Class
GO:0033337 biolink:NamedThing dorsal fin development The process whose specific outcome is the progression of the dorsal fin over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0102352 biolink:NamedThing phosphatidate kinase activity Catalysis of the reaction: ATP + a 1,2-diacyl-sn-glycerol 3-phosphate = ADP + a 1,2-diacyl-sn-glycerol 3-diphosphate. got7fsn_ti MetaCyc:RXN-13336 molecular_function owl:Class
GO:0060155 biolink:NamedThing platelet dense granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a platelet dense granule. A platelet dense granule is an electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins. got7fsn_ti bull's eye body organization and biogenesis|platelet dense body organization and biogenesis|platelet dense granule organisation|platelet dense granule organization and biogenesis biological_process owl:Class
GO:1990617 biolink:NamedThing CHOP-ATF4 complex A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits. got7fsn_ti GADD153-ATF4 complex|CHOP-CREB-2 complex|CHOP/ATF4 complex|ATF4-CHOP heterodimer|CHOP-ATF4 heterodimer bf 2015-01-22T11:29:51Z cellular_component owl:Class
GO:0045547 biolink:NamedThing dehydrodolichyl diphosphate synthase activity Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate. got7fsn_ti molecular_function owl:Class
GO:0001905 biolink:NamedThing activation of membrane attack complex The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis. got7fsn_ti activation of the terminal complement cascade|activation of MAC|activation of terminal complement complex|activation of TCC|MAC assembly|membrane attack complex assembly|membrane attack complex formation|MAC formation biological_process owl:Class
GO:0075042 biolink:NamedThing negative regulation of establishment of turgor in appressorium Any process that stops, prevents, or reduces the frequency, rate or extent of turgor formation in the symbiont appressorium. got7fsn_ti biological_process owl:Class
GO:0052815 biolink:NamedThing medium-chain acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length. got7fsn_ti medium-chain hydrolase activity|medium-chain-acyl-CoA hydrolase activity|medium-chain acyl-thioester hydrolase activity|medium-chain acyl coenzyme A hydrolase activity ai 2011-10-25T05:26:29Z molecular_function owl:Class
GO:0035609 biolink:NamedThing C-terminal protein deglutamylation The removal of a C-terminal, gene-encoded glutamate residue from a protein. got7fsn_ti protein primary sequence deglutamylation bf 2010-11-18T01:06:00Z biological_process owl:Class
GO:0072345 biolink:NamedThing NAADP-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts. got7fsn_ti mah 2010-11-10T01:03:35Z Reactome:R-HSA-2685505 molecular_function owl:Class
GO:0015278 biolink:NamedThing calcium-release channel activity Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti intracellular ligand-gated calcium channel activity GO:0005218 molecular_function owl:Class
GO:0000773 biolink:NamedThing phosphatidyl-N-methylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine. got7fsn_ti phosphatidyl-N-methylethanolamine methyltransferase activity|phospholipid methyltransferase activity|PLMT|methyltransferase II|phosphatidylmonomethylethanolamine methyltransferase activity|phosphatidylethanolamine methyltransferase I|S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity|phosphatidyl-N-monomethylethanolamine methyltransferase activity MetaCyc:2.1.1.71-RXN|EC:2.1.1.71|RHEA:32735 molecular_function owl:Class
GO:0070160 biolink:NamedThing tight junction A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. got7fsn_ti occluding cell junction|occluding junction Wikipedia:Tight_junction cellular_component owl:Class
GO:0031808 biolink:NamedThing H2 histamine receptor binding Binding to a H2 histamine receptor. got7fsn_ti H2 histamine receptor ligand molecular_function owl:Class
GO:1990875 biolink:NamedThing nucleoplasmic side of nuclear pore The side of the nuclear pore complex (NPC) that faces the nucleoplasm. got7fsn_ti nucleoplasmic side of nucleopore|nucleoplasmic side of NPC|nucleoplasmic side of nuclear pore complex sl 2015-10-01T21:32:22Z cellular_component owl:Class
GO:0043336 biolink:NamedThing site-specific telomere resolvase activity Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases. got7fsn_ti ResT|TelN Note that while this enzyme uses a similar reaction chemistry to topoisomerases and site-specific recombinases, it performs a unique reaction. Topoisomerases promote breakage and reunion of either one or two DNA strands to alter the topological state of a DNA molecule. Site-specific recombinases perform a more complex reaction in which four strands are broken and subsequently joined to a different DNA duplex, resulting in the production of a recombinant product. The telomere resolvases on the other hand, must break two phosphodiester bonds in a single DNA duplex (one on each strand) and join each end with the opposite DNA strand to form covalently closed hairpin telomeres. molecular_function owl:Class
GO:0097135 biolink:NamedThing cyclin E2-CDK2 complex A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:59:57Z cellular_component owl:Class
GO:0071487 biolink:NamedThing cellular response to low light intensity stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2. got7fsn_ti mah 2009-12-18T02:13:29Z biological_process owl:Class
GO:0006584 biolink:NamedThing catecholamine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. got7fsn_ti catecholamine metabolism biological_process owl:Class
GO:0008386 biolink:NamedThing cholesterol monooxygenase (side-chain-cleaving) activity Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. got7fsn_ti cytochrome P-450(scc) activity|steroid 20-22 desmolase activity|cholesterol C20-22 desmolase activity|cytochrome p450scc|cholesterol side-chain-cleaving enzyme activity|cholesterol 20-22-desmolase activity|C27-side chain cleavage enzyme|enzymes, cholesterol side-chain-cleaving|cholesterol side-chain cleavage enzyme activity|Cyp11a1|cholesterol C(20-22) desmolase activity|cytochrome P-450scc|steroid 20-22-lyase activity|cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)|desmolase, steroid 20-22|cholesterol desmolase activity|cytochrome p450(scc) activity RHEA:35739|MetaCyc:1.14.15.6-RXN|EC:1.14.15.6|Reactome:R-HSA-193065|Reactome:R-HSA-193054|Reactome:R-HSA-193101 molecular_function owl:Class
GO:1990084 biolink:NamedThing DnaA-Dps complex A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps. got7fsn_ti bhm 2013-04-30T11:50:17Z cellular_component owl:Class
GO:1990078 biolink:NamedThing replication inhibiting complex A protein complex that inhibits multiple events of replication initiation during one replication cycle. got7fsn_ti bhm 2013-04-26T13:07:03Z cellular_component owl:Class
GO:0090404 biolink:NamedThing pollen tube tip The region at growing end of the pollen tube cell, where polarized growth occurs. got7fsn_ti tb 2011-01-10T10:25:58Z cellular_component owl:Class
GO:0035637 biolink:NamedThing multicellular organismal signaling The transfer of information occurring at the level of a multicellular organism. got7fsn_ti multicellular organismal signalling bf 2011-01-14T10:13:50Z biological_process owl:Class
GO:0102749 biolink:NamedThing dihydrogeranylgeranyl-chlorophyll a reductase activity Catalysis of the reaction: H+ + dihydrogeranylgeranyl-chlorophyll a + NADPH = tetrahydrogeranylgeranyl-chlorophyll a + NADP. got7fsn_ti MetaCyc:RXN-7665 molecular_function owl:Class
GO:0061752 biolink:NamedThing telomeric repeat-containing RNA binding Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats. got7fsn_ti TERRA binding dph 2015-11-13T07:55:06Z molecular_function owl:Class
GO:0034885 biolink:NamedThing gamma-N-formylaminovinylacetate hydrolase activity Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH. got7fsn_ti UM-BBD_reactionID:r1350 molecular_function owl:Class
GO:1990396 biolink:NamedThing single-strand break repair via homologous recombination The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. got7fsn_ti bhm 2014-06-09T10:47:04Z biological_process owl:Class
GO:0000725 biolink:NamedThing recombinational repair A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. got7fsn_ti Wikipedia:Recombinational_repair biological_process owl:Class
GO:0044042 biolink:NamedThing glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. got7fsn_ti glucan metabolism biological_process owl:Class
GO:0004712 biolink:NamedThing protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. got7fsn_ti dual-specificity kinase activity|dual-specificity protein kinase|protein threonine/tyrosine kinase activity RHEA:10596|RHEA:46608|Reactome:R-HSA-6802922|Reactome:R-HSA-6802927|EC:2.7.12.1|Reactome:R-HSA-6802918|Reactome:R-HSA-6802910|Reactome:R-HSA-6802921|Reactome:R-HSA-6802916|RHEA:17989|Reactome:R-HSA-6802941|Reactome:R-HSA-6802924|Reactome:R-HSA-5674373|Reactome:R-HSA-9656212|Reactome:R-HSA-5672969 molecular_function owl:Class
GO:0031962 biolink:NamedThing mineralocorticoid receptor binding Binding to a mineralocorticoid receptor. got7fsn_ti molecular_function owl:Class
GO:0061057 biolink:NamedThing peptidoglycan recognition protein signaling pathway A series of molecular signals initiated by binding of peptidoglycan to a receptor and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides. got7fsn_ti Imd signaling pathway|immune deficiency pathway|Imd signalling pathway|PGRP signaling pathway|immune deficiency signaling pathway dph 2010-03-02T12:20:10Z biological_process owl:Class
GO:0140282 biolink:NamedThing carbon-nitrogen ligase activity on lipid II Catalysis of the reaction: L-glutamine + lipid II + ATP + H2O = L-glutamate + beta-D-GlcNAc(1->4)-Mur2Ac(oyl-L-Ala-D-isoGln-L-Lys-D-Ala-D-Ala)-diphospho-di-trans,octa-cis-undecaprenol + ADP + phosphate. got7fsn_ti L-glutamate--lipid II transaminase activity|carbon-nitrogen ligase activity on lipid II|undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl pentapeptide amidotransferase (glutamine-hydrolyzing) activity https://github.com/geneontology/go-ontology/issues/16422 pg 2018-10-08T19:12:57Z RHEA:57928|EC:6.3.5.13 molecular_function owl:Class
GO:0051509 biolink:NamedThing tomatidine UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + tomatidine = UDP + O-glucosyl-tomatidine. got7fsn_ti molecular_function owl:Class
GO:0044567 biolink:NamedThing primary cell wall cellulose synthase complex A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein. got7fsn_ti primary cell wall CESA complex|primary cell-wall cellulose synthase complex jl 2012-04-18T12:24:16Z cellular_component owl:Class
GO:0071035 biolink:NamedThing nuclear polyadenylation-dependent rRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, including RNA fragments released as part of processing the primary transcript into multiple mature rRNA species, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA. got7fsn_ti nuclear poly(A)-dependent rRNA catabolic process krc 2009-07-29T12:42:39Z biological_process owl:Class
GO:0046152 biolink:NamedThing ommochrome metabolic process The chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. got7fsn_ti ommochrome metabolism biological_process owl:Class
GO:0102821 biolink:NamedThing bixin methyltransferase activity Catalysis of the reaction: bixin + S-adenosyl-L-methionine <=> bixin dimethyl ester + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-8239 molecular_function owl:Class
GO:0021911 biolink:NamedThing retinoic acid metabolic process in spinal cord anterior-posterior patterning The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord. got7fsn_ti retinoic acid metabolism in spinal cord anterior-posterior patterning biological_process owl:Class
GO:0042573 biolink:NamedThing retinoic acid metabolic process The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. got7fsn_ti retinoic acid metabolism|vitamin A1 acid metabolic process|vitamin A1 acid metabolism biological_process owl:Class
GO:0000730 biolink:NamedThing DNA recombinase assembly The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA. got7fsn_ti Rad51 nucleoprotein filament formation biological_process owl:Class
GO:0106379 biolink:NamedThing 8-oxo-(d)RTP hydrolase activity Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+. got7fsn_ti hjd 2021-05-26T14:36:55Z molecular_function owl:Class
GO:0046910 biolink:NamedThing pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase. got7fsn_ti See also the molecular function term 'pectinesterase activity ; GO:0030599'. molecular_function owl:Class
GO:0042802 biolink:NamedThing identical protein binding Binding to an identical protein or proteins. got7fsn_ti protein homopolymerization|isoform-specific homophilic binding molecular_function owl:Class
GO:0007274 biolink:NamedThing neuromuscular synaptic transmission The process of synaptic transmission from a neuron to a muscle, across a synapse. got7fsn_ti biological_process owl:Class
GO:0033668 biolink:NamedThing negative regulation by symbiont of host apoptotic process Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti downregulation by organism of host apoptotic programmed cell death|inhibition by organism of host apoptotic programmed cell death|negative regulation by symbiont of host apoptosis|down-regulation by organism of host apoptotic programmed cell death|down regulation by organism of host apoptotic programmed cell death Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'negative regulation of apoptosis ; GO:0043066'. biological_process owl:Class
GO:0097492 biolink:NamedThing sympathetic neuron axon guidance The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti sympathetic neuron axon growth cone guidance|sympathetic neuron axon chemotaxis|sympathetic neuron axon pathfinding pr 2013-07-10T11:50:52Z biological_process owl:Class
GO:0030961 biolink:NamedThing peptidyl-arginine hydroxylation The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine. got7fsn_ti biological_process owl:Class
GO:0010191 biolink:NamedThing mucilage metabolic process The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants. got7fsn_ti mucilage metabolism biological_process owl:Class
GO:1990482 biolink:NamedThing sphingolipid alpha-glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC. got7fsn_ti inositol phosphorylceramide glucuronosyltransferase activity tb 2014-09-12T22:10:09Z molecular_function owl:Class
GO:0070996 biolink:NamedThing type 1 melanocortin receptor binding Binding to a type 1 melanocortin receptor. got7fsn_ti type 1 melanocortin receptor ligand mah 2009-11-03T01:50:53Z molecular_function owl:Class
GO:0004810 biolink:NamedThing tRNA adenylyltransferase activity Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1). got7fsn_ti tRNA-nucleotidyltransferase activity|ribonucleic cytidylic cytidylic adenylic pyrophosphorylase|transfer ribonucleic-terminal trinucleotide nucleotidyltransferase|transfer ribonucleate adenylyltransferase|transfer ribonucleic acid nucleotidyl transferase|-C-C-A pyrophosphorylase|CCA-adding enzyme activity|ATP:tRNA adenylyltransferase activity|ATP(CTP)-tRNA nucleotidyltransferase|transfer RNA adenylyltransferase|ribonucleic cytidylyltransferase|transfer ribonucleic adenylyl (cytidylyl) transferase|transfer ribonucleate cytidylyltransferase|transfer-RNA nucleotidyltransferase|transfer ribonucleate adenyltransferase activity|ATP (CTP):tRNA nucleotidyltransferase|tRNA adenylyl(cytidylyl)transferase|tRNA CCA-diphosphorylase activity|tRNA CCA-pyrophosphorylase activity|transfer ribonucleate nucleotidyltransferase|CTP(ATP):tRNA nucleotidyltransferase MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN|EC:2.7.7.72 molecular_function owl:Class
GO:1990817 biolink:NamedThing RNA adenylyltransferase activity Catalysis of the template-independent extension of the 3'- end of an RNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA, or oligo(A) bearing a 3'-OH terminal group. got7fsn_ti vw 2015-07-31T09:38:31Z molecular_function owl:Class
GO:0001715 biolink:NamedThing ectodermal cell fate specification The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti ectoderm cell fate specification biological_process owl:Class
GO:0004851 biolink:NamedThing uroporphyrin-III C-methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2. got7fsn_ti SirA|adenosylmethionine-uroporphyrinogen III methyltransferase activity|urogen III methylase activity|SUMT activity|uroporphyrinogen-III C-methyltransferase activity|uroporphyrinogen-III methylase activity|CysG|S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity|uroporphyrinogen methyltransferase activity|uroporphyrinogen-III methyltransferase activity|uroporphyrinogen III methylase activity|CobA|S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity|S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity EC:2.1.1.107|MetaCyc:UROPORIIIMETHYLTRANSA-RXN|RHEA:32459 molecular_function owl:Class
GO:0047980 biolink:NamedThing hippurate hydrolase activity Catalysis of the reaction: N-benzoylglycine + H(2)O = benzoate + glycine. got7fsn_ti benzoylglycine amidohydrolase activity|hippuricase activity|N-benzoylamino-acid amidohydrolase activity MetaCyc:HIPPURATE-HYDROLASE-RXN|RHEA:10424|EC:3.5.1.32|KEGG_REACTION:R01424 molecular_function owl:Class
GO:0031363 biolink:NamedThing N-terminal protein amino acid deamination The removal of an amino group from the N-terminal amino acid residue of a protein. got7fsn_ti biological_process owl:Class
GO:0060106 biolink:NamedThing cortical layer of collagen and cuticulin-based cuticle extracellular matrix The cuticle layer that lies directly beneath the lipid-containing epicuticle. The cortical layer contains collagens and insoluble, non-collagenous cuticulins and is characterized by a distinct annular pattern consisting of regularly spaced annular ridges delineated by annular furrows. An example of this component is found in Caenorhabditis elegans. got7fsn_ti cellular_component owl:Class
GO:0010784 biolink:NamedThing proboscis morphogenesis, clypeo-labral disc-derived The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized. got7fsn_ti biological_process owl:Class
GO:0018035 biolink:NamedThing C-terminal peptidyl-arginine amidation The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0082 biological_process owl:Class
GO:0050258 biolink:NamedThing riboflavinase activity Catalysis of the reaction: H(2)O + H(+) + riboflavin = D-ribitol + lumichrome. got7fsn_ti riboflavin hydrolase activity KEGG_REACTION:R01732|EC:3.5.99.1|MetaCyc:RIBOFLAVINASE-RXN|RHEA:11408 molecular_function owl:Class
GO:0001998 biolink:NamedThing angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream. got7fsn_ti angiotensin mediated vasoconstriction during blood pressure regulation|angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure|angiotensin mediated vasoconstriction during blood pressure control|angiotensin mediated vasoconstriction during control of blood pressure biological_process owl:Class
GO:0050136 biolink:NamedThing NADH dehydrogenase (quinone) activity Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. got7fsn_ti NADH-quinone oxidoreductase activity|reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity|D-diaphorase activity|NADH:(quinone-acceptor) oxidoreductase activity|DPNH-menadione reductase activity RHEA:46160|MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN|EC:1.6.5.11 molecular_function owl:Class
GO:0039523 biolink:NamedThing suppression by virus of host RNA polymerase II activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host RNA polymerase II activity. got7fsn_ti inhibition of host RNA polymerase II activity by virus|negative regulation by virus of host RNA polymerase II activity|inhibition of host RNA polymerase II by virus bf 2011-06-22T04:38:59Z VZ:905 biological_process owl:Class
GO:0010205 biolink:NamedThing photoinhibition The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II. got7fsn_ti photosystem II inhibition Wikipedia:Photoinhibition biological_process owl:Class
GO:0052896 biolink:NamedThing spermidine oxidase (propane-1,3-diamine-forming) activity Catalysis of the reaction: H(2)O + O(2) + spermidine = 1,3-diaminopropane + 4-aminobutanal + H(2)O(2). got7fsn_ti polyamine oxidase (propane-1,3-diamine-forming) activity|spermidine:(acceptor) oxidoreductase activity MetaCyc:RXN-10747|RHEA:25820|KEGG_REACTION:R01914|EC:1.5.3.14 molecular_function owl:Class
GO:1903011 biolink:NamedThing negative regulation of bone development Any process that stops, prevents or reduces the frequency, rate or extent of bone development. got7fsn_ti down-regulation of bone development|downregulation of bone development|inhibition of bone development|down regulation of bone development mr 2014-05-13T22:42:00Z biological_process owl:Class
GO:1903010 biolink:NamedThing regulation of bone development Any process that modulates the frequency, rate or extent of bone development. got7fsn_ti mr 2014-05-13T22:41:53Z biological_process owl:Class
GO:0060503 biolink:NamedThing bud dilation involved in lung branching The process in which a bud in the lung increases radially. got7fsn_ti bud expansion biological_process owl:Class
GO:0035401 biolink:NamedThing histone kinase activity (H3-Y41 specific) Catalysis of the transfer of a phosphate group to the tyrosine-41 residue of histone H3. got7fsn_ti histone-tyrosine kinase activity (H3-Y41 specific)|histone tyrosine kinase activity (H3-Y41 specific) bf 2010-03-24T10:01:14Z molecular_function owl:Class
GO:0006169 biolink:NamedThing adenosine salvage Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis. got7fsn_ti adenine, hypoxanthine and their nucleoside salvage biological_process owl:Class
GO:0046086 biolink:NamedThing adenosine biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes. got7fsn_ti adenosine biosynthesis|adenosine formation|adenosine anabolism|adenosine synthesis biological_process owl:Class
GO:1990572 biolink:NamedThing TERT-RMRP complex A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP). got7fsn_ti telomerase reverse transcriptase:RMRP RNA complex bf 2014-12-02T11:29:12Z cellular_component owl:Class
GO:0097313 biolink:NamedThing bacterial biofilm matrix surface The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. got7fsn_ti pr 2012-05-24T11:25:47Z cellular_component owl:Class
GO:1990329 biolink:NamedThing IscS-TusA complex A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups. got7fsn_ti bhm 2014-03-17T10:00:47Z cellular_component owl:Class
GO:1990221 biolink:NamedThing L-cysteine desulfurase complex A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer. got7fsn_ti SufS complex|NIFS|IscS|NifS bhm 2013-10-11T15:36:34Z cellular_component owl:Class
GO:0051006 biolink:NamedThing positive regulation of lipoprotein lipase activity Any process that activates or increases the activity of the enzyme lipoprotein lipase. got7fsn_ti stimulation of lipoprotein lipase activity|up-regulation of lipoprotein lipase activity|up regulation of lipoprotein lipase activity|upregulation of lipoprotein lipase activity|activation of lipoprotein lipase activity biological_process owl:Class
GO:0061365 biolink:NamedThing positive regulation of triglyceride lipase activity Any process that increases the activity of triglyceride lipase. got7fsn_ti positive regulation of TAG activity dph 2010-10-15T08:27:22Z biological_process owl:Class
GO:0047809 biolink:NamedThing D-2-hydroxy-acid dehydrogenase activity Catalysis of the reaction: (R)-lactate + A = AH(2) + pyruvate. got7fsn_ti 2-hydroxy acid dehydrogenase activity|(R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase activity KEGG_REACTION:R00297|RHEA:15089|EC:1.1.99.6|MetaCyc:D-2-HYDROXY-ACID-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0072571 biolink:NamedThing mono-ADP-D-ribose binding Binding to monomeric ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment. got7fsn_ti mono-ADP-ribose binding|mADPr binding mah 2011-01-31T02:39:12Z molecular_function owl:Class
GO:0072570 biolink:NamedThing ADP-D-ribose binding Binding to ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment. got7fsn_ti ADP-ribose binding mah 2011-01-31T02:37:30Z molecular_function owl:Class
GO:0031145 biolink:NamedThing anaphase-promoting complex-dependent catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. got7fsn_ti anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|APC-dependent proteasomal ubiquitin-dependent protein catabolism|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown|cyclin catabolic process|negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation|cyclin degradation|APC-dependent proteasomal ubiquitin-dependent protein catabolic process|cyclin catabolism|cyclin breakdown|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism|degradation of cyclin|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation GO:0008054 biological_process owl:Class
GO:0036528 biolink:NamedThing peptidyl-lysine deglycation The removal of a sugar or dicarbonyl from a lysine residue of a glycated protein. got7fsn_ti deglycation of N-acetyllysine bf 2016-08-04T10:37:12Z biological_process owl:Class
GO:0047656 biolink:NamedThing alpha,alpha-trehalose phosphorylase activity Catalysis of the reaction: alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate. got7fsn_ti alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase activity|trehalose phosphorylase|a,a-trehalose phosphorylase activity MetaCyc:ALPHAALPHA-TREHALOSE-PHOSPHORYLASE-RXN|RHEA:23512|EC:2.4.1.64 molecular_function owl:Class
GO:0047394 biolink:NamedThing glycerophosphoinositol inositolphosphodiesterase activity Catalysis of the reaction: H2O + 1-(sn-glycero-3-phospho)-1D-myoinositol = 1D-myo-inositol 1-phosphate + glycerol. got7fsn_ti 1,2-cyclic-inositol-phosphate phosphodiesterase activity|inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity|D-myo-inositol 1:2-cyclic phosphate 2-phosphohydrolase activity|D-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity|1-D-myo-inositol-1,2-cyclic-phosphate 2-inositolphosphohydrolase activity|D-myo-inositol 1,2-cyclic phosphate 2-phosphohydrolase activity|1-(sn-glycero-3-phospho)-1D-myo-inositol inositolphosphohydrolase activity RHEA:14033|EC:3.1.4.43|MetaCyc:3.1.4.43-RXN molecular_function owl:Class
GO:0070733 biolink:NamedThing protein adenylyltransferase activity Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to specific residues of target proteins. got7fsn_ti AMPylator|adenosine monophosphate-protein transferase activity mah 2009-06-18T01:09:15Z EC:2.7.7.n1 molecular_function owl:Class
GO:0008355 biolink:NamedThing olfactory learning Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. got7fsn_ti biological_process owl:Class
GO:0009769 biolink:NamedThing photosynthesis, light harvesting in photosystem II After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center. got7fsn_ti biological_process owl:Class
GO:0020020 biolink:NamedThing food vacuole Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa. got7fsn_ti digestive vacuole GO:0005772 cellular_component owl:Class
GO:0001003 biolink:NamedThing RNA polymerase III type 2 promoter sequence-specific DNA binding Binding to a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs. got7fsn_ti RNA polymerase III type 2 promoter DNA binding krc 2010-08-18T05:51:18Z GO:0001031 molecular_function owl:Class
GO:0032370 biolink:NamedThing positive regulation of lipid transport Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti stimulation of lipid transport|activation of lipid transport|up regulation of lipid transport|upregulation of lipid transport|up-regulation of lipid transport biological_process owl:Class
GO:0030131 biolink:NamedThing clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. got7fsn_ti cellular_component owl:Class
GO:0020006 biolink:NamedThing symbiont-containing vacuolar membrane network Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm. got7fsn_ti parasitophorous vacuolar membrane network|tubulovesicular network|symbiont-containing vacuole membrane network cellular_component owl:Class
GO:0120267 biolink:NamedThing pellicular membrane The portion of the plasma membrane surrounding the pellicle, a structure enclosing some parasite cells such as certain apicomplexa and Euglenozoa. These membranes are associated with an infrastructure of microtubules, microfilaments, and other organelles. got7fsn_ti pellicle membrane|pellicular plasma membrane https://github.com/geneontology/go-ontology/issues/20034 This sub-domain of the plasma membrane excludes the ciliary and ciliary pocket membranes. krc 2020-09-29T21:08:28Z cellular_component owl:Class
GO:0070497 biolink:NamedThing 6-carboxy-5,6,7,8-tetrahydropterin synthase activity Catalysis of the reaction: 7,8-dihydroneopterin triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H+. got7fsn_ti MetaCyc:RXN0-5507|EC:4.1.2.50|RHEA:27966 molecular_function owl:Class
GO:0048251 biolink:NamedThing elastic fiber assembly Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching. got7fsn_ti elastin fiber assembly|elastic fibre assembly|elastin fibre assembly biological_process owl:Class
GO:0032470 biolink:NamedThing positive regulation of endoplasmic reticulum calcium ion concentration Any process that increases the concentration of calcium ions in the endoplasmic reticulum. got7fsn_ti elevation of endoplasmic reticulum calcium ion concentration|endoplasmic reticulum calcium ion concentration elevation|elevation of ER calcium ion concentration|elevation of calcium ion concentration in endoplasmic reticulum biological_process owl:Class
GO:0051236 biolink:NamedThing establishment of RNA localization The directed movement of RNA to a specific location. got7fsn_ti RNA recruitment|establishment of RNA localisation|RNA positioning biological_process owl:Class
GO:0070649 biolink:NamedThing formin-nucleated actin cable assembly The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. got7fsn_ti formin-nucleated actin cable formation mah 2009-05-12T02:14:36Z biological_process owl:Class
GO:0034657 biolink:NamedThing GID complex A protein complex with ubiquitin ligase activity that is involved in proteasomal degradation of fructose-1,6-bisphosphatase (FBPase) and phosphoenolpyruvate carboxykinase during the transition from gluconeogenic to glycolytic growth conditions. In S. cerevisiae, the GID (Glucose Induced degradation Deficient) complex consists of Vid30p, Rmd5p, Vid24p, Vid28p, Gid7p, Gid8p, and Fyv10p. got7fsn_ti cellular_component owl:Class
GO:0005150 biolink:NamedThing interleukin-1, type I receptor binding Binding to a Type I interleukin-1 receptor. got7fsn_ti interleukin-1, type I receptor ligand|IL-1 type I molecular_function owl:Class
GO:0035778 biolink:NamedThing pronephric nephron tubule epithelial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state. got7fsn_ti bf 2011-04-04T11:07:47Z biological_process owl:Class
GO:0039014 biolink:NamedThing cell differentiation involved in pronephros development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state. got7fsn_ti cell differentiation involved in pronephric kidney development bf 2010-07-02T09:59:25Z biological_process owl:Class
GO:0016577 biolink:NamedThing histone demethylation The modification of histones by removal of methyl groups. got7fsn_ti biological_process owl:Class
GO:0044740 biolink:NamedThing negative regulation of sensory perception of pain in other organism A process that negatively regulates the sensory perception of pain in a different organism. got7fsn_ti inhibition of sensory perception of pain in another organism jl 2012-11-07T13:43:10Z biological_process owl:Class
GO:0047610 biolink:NamedThing acetylsalicylate deacetylase activity Catalysis of the reaction: acetylsalicylate + H(2)O = acetate + H(+) + salicylate. got7fsn_ti aspirin esterase activity|aspirin hydrolase activity|acetylsalicylate O-acetylhydrolase activity|acetylsalicylic acid esterase activity RHEA:11752|EC:3.1.1.55|MetaCyc:ACETYLSALICYLATE-DEACETYLASE-RXN|KEGG_REACTION:R02942 molecular_function owl:Class
GO:0035081 biolink:NamedThing induction of programmed cell death by hormones Any process induced by hormones that directly activates any of the steps required for programmed cell death. got7fsn_ti biological_process owl:Class
GO:0012502 biolink:NamedThing induction of programmed cell death A process which directly activates any of the steps required for programmed cell death. got7fsn_ti induction of non-apoptotic programmed cell death|induction of nonapoptotic programmed cell death GO:0012503 biological_process owl:Class
GO:0035518 biolink:NamedThing histone H2A monoubiquitination The modification of histone H2A by addition of a single ubiquitin group. got7fsn_ti bf 2010-05-04T04:22:09Z biological_process owl:Class
GO:0110155 biolink:NamedThing NAD-cap decapping Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes. got7fsn_ti kmv 2019-07-08T17:27:56Z biological_process owl:Class
GO:0009360 biolink:NamedThing DNA polymerase III complex The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. got7fsn_ti DNA polymerase III holoenzyme complex cellular_component owl:Class
GO:0034320 biolink:NamedThing alcohol O-hexanoyltransferase activity Catalysis of the reaction: hexanoyl-CoA + an alcohol = CoA + a hexyl ester. got7fsn_ti molecular_function owl:Class
GO:0071182 biolink:NamedThing MAML3-RBP-Jkappa-ICN4 complex A protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML3-RBP-Jkappa-Notch4 complex mah 2009-11-23T02:52:35Z cellular_component owl:Class
GO:0038100 biolink:NamedThing nodal binding Binding to a nodal protein, a member of the transforming growth factor-beta superfamily. got7fsn_ti bf 2012-02-17T11:19:08Z molecular_function owl:Class
GO:0031515 biolink:NamedThing tRNA (m1A) methyltransferase complex A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer. got7fsn_ti cellular_component owl:Class
GO:0043527 biolink:NamedThing tRNA methyltransferase complex A multimeric protein complex involved in the methylation of specific nucleotides in tRNA. got7fsn_ti cellular_component owl:Class
GO:0060458 biolink:NamedThing right lung development The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect. got7fsn_ti right pulmonary development biological_process owl:Class
GO:0010038 biolink:NamedThing response to metal ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. got7fsn_ti heavy metal sensitivity/resistance|response to heavy metal|response to metal biological_process owl:Class
GO:0071610 biolink:NamedThing chemokine (C-C motif) ligand 1 production The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CCL1 production|TCA-3 production|T cell activation 3 production mah 2010-02-05T04:35:00Z biological_process owl:Class
GO:0018626 biolink:NamedThing 2-chlorobenzoate 1,2-dioxygenase activity Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2. got7fsn_ti 2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)|2-halobenzoate 1,2-dioxygenase activity EC:1.14.12.13|UM-BBD_reactionID:r0632|RHEA:21652|MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN molecular_function owl:Class
GO:0016675 biolink:NamedThing oxidoreductase activity, acting on a heme group of donors Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. got7fsn_ti oxidoreductase activity, acting on heme group of donors, other acceptors|oxidoreductase activity, acting on haem group of donors EC:1.9.-.- molecular_function owl:Class
GO:0052639 biolink:NamedThing salicylic acid glucosyltransferase (ester-forming) activity Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid glucose ester + UDP. got7fsn_ti UDP:glucose:SA glucosyltransferase (ester-forming) activity|salicylic acid glucosyltransferase activity|UDP:glucose:salicylic acid glucosyltransferase (ester-forming) activity|UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (ester-forming) activity|UDP:glucose:salicylate glucosyltransferase (ester-forming) activity RHEA:62316|MetaCyc:RXN-11659 molecular_function owl:Class
GO:0002121 biolink:NamedThing inter-male aggressive behavior Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious. got7fsn_ti inter-male aggression biological_process owl:Class
GO:0048580 biolink:NamedThing regulation of post-embryonic development Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. got7fsn_ti biological_process owl:Class
GO:0050529 biolink:NamedThing polyneuridine-aldehyde esterase activity Catalysis of the reaction: H(2)O + polyneuridine aldehyde = 16-epivellosimine + CO(2) + methanol. got7fsn_ti polyneuridine aldehyde esterase activity|polyneuridine aldehyde hydrolase (decarboxylating)|PNAE activity EC:3.1.1.78|RHEA:17501|KEGG_REACTION:R05825|MetaCyc:3.1.1.78-RXN molecular_function owl:Class
GO:0106321 biolink:NamedThing S-(hydroxymethyl)glutathione dehydrogenase NADP activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+. got7fsn_ti hjd 2020-09-23T15:26:27Z RHEA:19981|EC:1.1.1.284 molecular_function owl:Class
GO:0051903 biolink:NamedThing S-(hydroxymethyl)glutathione dehydrogenase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. got7fsn_ti S-(hydroxymethyl)glutathione:NAD+ oxidoreductase activity|glutathione-dependent formaldehyde dehydrogenase activity|formic dehydrogenase activity|FDH activity|chi-ADH activity|NAD- and glutathione-dependent formaldehyde dehydrogenase activity|class III alcohol dehydrogenase activity|NAD-dependent formaldehyde dehydrogenase activity|ADH3 activity|NAD-linked formaldehyde dehydrogenase activity|GS-FDH activity|GD-FALDH activity UM-BBD_reactionID:r1146|MetaCyc:RXN-2962|EC:1.1.1.284|Reactome:R-HSA-5692237|KEGG_REACTION:R07140|KEGG_REACTION:R06983 molecular_function owl:Class
GO:1990808 biolink:NamedThing F-bar domain binding Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins. got7fsn_ti vw 2015-07-21T18:43:00Z molecular_function owl:Class
GO:0097220 biolink:NamedThing simple sieve plate A sieve plate that contains a single specialized sieve area. got7fsn_ti Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell. pr 2012-01-13T05:46:46Z cellular_component owl:Class
GO:0047084 biolink:NamedThing methyltetrahydroprotoberberine 14-monooxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + (S)-N-methylcanadine = H2O + NADP+ + allocryptopine. got7fsn_ti (S)-cis-N-methyltetrahydroberberine 14-monooxygenase activity|(S)-cis-N-methyltetrahydroprotoberberine-14-hydroxylase activity|methyltetrahydroprotoberberine 14-hydroxylase activity|(S)-N-methylcanadine,NADPH:oxygen oxidoreductase (14-hydroxylating) RHEA:23684|EC:1.14.14.97|MetaCyc:1.14.13.37-RXN molecular_function owl:Class
GO:0018074 biolink:NamedThing peptidyl-histidine bromination The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown. got7fsn_ti RESID:AA0173 biological_process owl:Class
GO:0003110 biolink:NamedThing positive regulation of the force of heart contraction by neuronal norepinephrine The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction. got7fsn_ti increased force of heart contraction by neuronal noradrenaline|increased force of heart contraction by neuronal norepinephrine biological_process owl:Class
GO:0071427 biolink:NamedThing mRNA-containing ribonucleoprotein complex export from nucleus The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm. got7fsn_ti mRNA-containing RNP export from nucleus|mRNA-containing ribonucleoprotein complex nucleus export|mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm|mRNA-containing ribonucleoprotein complex export from cell nucleus mah 2009-12-16T10:13:59Z biological_process owl:Class
GO:0046924 biolink:NamedThing peptide cross-linking via 2-(S-L-cysteinyl)-L-phenylalanine The cross-linking of a cysteine residue to an L-phenylalanine residue to form 2-(S-L-cysteinyl)-L-phenylalanine. got7fsn_ti RESID:AA0340 biological_process owl:Class
GO:0097550 biolink:NamedThing transcription preinitiation complex A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. got7fsn_ti transcription preinitiation complex|PIC|transcriptional pre-initiation complex|transcriptional preinitiation complex|preinitiation complex|DNA-templated transcriptional preinitiation complex pr 2014-01-22T09:33:44Z cellular_component owl:Class
GO:0103117 biolink:NamedThing UDP-3-O-acyl-N-acetylglucosamine deacetylase activity Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-N-acetylglucosamine(2-) + H2O <=> UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + acetate. got7fsn_ti EC:3.5.1.108|MetaCyc:UDPACYLGLCNACDEACETYL-RXN|RHEA:25209 molecular_function owl:Class
GO:0046863 biolink:NamedThing ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity Increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate. got7fsn_ti rubisco activase activity|ribulose-1,5-bisphosphate carboxylase/oxygenase activase activity|rubisco activator|ribulose-bisphosphate carboxylase activase activity See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. GO:0018236 molecular_function owl:Class
GO:0047921 biolink:NamedThing aminoglycoside 2'-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + gentamicin C(1a) = N(2')-acetylgentamicin C(1a) + CoA + H(+). This is acetylation of the 2'-amino group of the 6-deoxy-6-aminoglucose ring. got7fsn_ti gentamycin acetyltransferase II|acetyl-CoA:gentamicin-C1a N2'-acetyltransferase activity|acetyl-CoA:gentamycin-C1a N2'-acetyltransferase activity|gentamicin acetyltransferase II activity|gentamicin 2'-N-acetyltransferase activity|gentamycin 2'-N-acetyltransferase activity RHEA:24516|MetaCyc:GENTAMICIN-2-N-ACETYLTRANSFERASE-RXN|KEGG_REACTION:R03056|EC:2.3.1.59 molecular_function owl:Class
GO:0034247 biolink:NamedThing snoRNA splicing The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA. got7fsn_ti biological_process owl:Class
GO:0007341 biolink:NamedThing penetration of zona pellucida The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm. got7fsn_ti biological_process owl:Class
GO:0047756 biolink:NamedThing chondroitin 4-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate. got7fsn_ti 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase activity|chondroitin 4-sulphotransferase activity Reactome:R-HSA-1971483|RHEA:16101|EC:2.8.2.5|MetaCyc:CHONDROITIN-4-SULFOTRANSFERASE-RXN molecular_function owl:Class
GO:0070781 biolink:NamedThing response to biotin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus. got7fsn_ti response to coenzyme R|response to vitamin B7|response to Bios IIB|response to vitamin H mah 2009-07-02T02:34:43Z biological_process owl:Class
GO:1990234 biolink:NamedThing transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). got7fsn_ti bhm 2013-11-12T13:20:12Z cellular_component owl:Class
GO:0047007 biolink:NamedThing pregnan-21-ol dehydrogenase (NAD+) activity Catalysis of the reaction: NAD(+) + pregnan-21-ol = H(+) + NADH + pregnan-21-al. got7fsn_ti 21-hydroxysteroid dehydrogenase (NAD+) activity|21-hydroxysteroid:NAD+ 21-oxidoreductase activity EC:1.1.1.150|RHEA:11448|KEGG_REACTION:R03043|MetaCyc:1.1.1.150-RXN molecular_function owl:Class
GO:0106076 biolink:NamedThing peptide-lysine-N-succinyltransferase activity Catalysis of the reaction: succinyl-CoA + lysine in peptide = CoA + N-succinyl-lysine-peptide. got7fsn_ti hjd 2017-12-15T18:25:16Z molecular_function owl:Class
GO:0106075 biolink:NamedThing peptide N-succinyltransferase activity Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: succinyl-CoA + peptide = CoA + N-succinylpeptide. got7fsn_ti hjd 2017-12-15T18:23:58Z molecular_function owl:Class
GO:0018046 biolink:NamedThing C-terminal peptidyl-methionine amidation The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0093 biological_process owl:Class
GO:0051593 biolink:NamedThing response to folic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. got7fsn_ti cellular response to folate|cellular response to vitamin B9 biological_process owl:Class
GO:0060845 biolink:NamedThing venous endothelial cell fate commitment The commitment of a cell to a venous endothelial cell fate and its capacity to differentiate into an venous endothelial cell. got7fsn_ti dph 2009-08-12T10:51:23Z biological_process owl:Class
GO:0060846 biolink:NamedThing blood vessel endothelial cell fate commitment The commitment of a cell to a blood vessel endothelial cell fate and its capacity to differentiate into a blood vessel endothelial cell. got7fsn_ti dph 2009-08-12T10:56:14Z biological_process owl:Class
GO:0075028 biolink:NamedThing negative regulation of appressorium initiation Any process that stops, prevents, or reduces the frequency, rate or extent symbiont appressorium initiation. got7fsn_ti negative regulation of appressorium initiation on or near host|negative regulation of initiation of appressorium on or near host biological_process owl:Class
GO:0001066 biolink:NamedThing plastid single subunit type RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti krc 2010-10-19T03:54:57Z molecular_function owl:Class
GO:0043180 biolink:NamedThing rhythmic inhibition Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit. got7fsn_ti biological_process owl:Class
GO:0106368 biolink:NamedThing dTTP dependent (deoxy)nucleoside - phosphate kinase activity Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP. got7fsn_ti hjd 2021-03-11T20:09:34Z RHEA:62132 molecular_function owl:Class
GO:2000252 biolink:NamedThing negative regulation of feeding behavior Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior. got7fsn_ti negative regulation of behavioural response to food|negative regulation of eating|negative regulation of feeding behaviour|negative regulation of drinking|negative regulation of behavioral response to food yaf 2010-11-18T11:24:14Z biological_process owl:Class
GO:0060259 biolink:NamedThing regulation of feeding behavior Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food. got7fsn_ti regulation of feeding behaviour biological_process owl:Class
GO:0047913 biolink:NamedThing gallate 1-beta-glucosyltransferase activity Catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP. got7fsn_ti UDPglucose-vanillate 1-glucosyltransferase activity|gallate 1-b-glucosyltransferase activity|UDP-glucose-vanillate 1-glucosyltransferase activity|UDP-glucose:gallate beta-D-glucosyltransferase activity|UDPglucose:gallate glucosyltransferase activity|UDPglucose:vanillate 1-O-glucosyltransferase activity|UDPglucose:gallate beta-D-glucosyltransferase activity KEGG_REACTION:R03297|EC:2.4.1.136|MetaCyc:GALLATE-1-BETA-GLUCOSYLTRANSFERASE-RXN|RHEA:15249 molecular_function owl:Class
GO:0009314 biolink:NamedThing response to radiation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. got7fsn_ti response to radiation stimulus|response to electromagnetic radiation stimulus Note that 'radiation' refers to electromagnetic radiation of any wavelength. biological_process owl:Class
GO:0060974 biolink:NamedThing cell migration involved in heart formation The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells. got7fsn_ti dph 2009-10-06T10:56:33Z biological_process owl:Class
GO:0015934 biolink:NamedThing large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). got7fsn_ti ribosomal large subunit cellular_component owl:Class
GO:0016624 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. got7fsn_ti oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor EC:1.2.4.- molecular_function owl:Class
GO:0030033 biolink:NamedThing microvillus assembly Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. got7fsn_ti microvillus biogenesis biological_process owl:Class
GO:0032528 biolink:NamedThing microvillus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell. got7fsn_ti microvillus organisation|microvillus organization and biogenesis biological_process owl:Class
GO:0044188 biolink:NamedThing host cell lysosomal membrane The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm. got7fsn_ti jl 2009-10-15T03:27:54Z cellular_component owl:Class
GO:0051866 biolink:NamedThing general adaptation syndrome General adaptation syndrome is the set of changes in various organ systems of the body, especially the pituitary-endocrine system, in response to a wide range of strong external stimuli, both physiological and psychological. It is described as having three stages: alarm reaction, where the body detects the external stimulus; adaptation, where the body engages defensive countermeasures against the stressor; and exhaustion, where the body begins to run out of defenses. got7fsn_ti physiological response during general adaptation syndrome|physiological process during general adaptation syndrome|general adaptation syndrome, physiological process|general adaptation syndrome, physiological response GO:0051868 biological_process owl:Class
GO:0033555 biolink:NamedThing multicellular organismal response to stress Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti biological_process owl:Class
GO:0050076 biolink:NamedThing maleate isomerase activity Catalysis of the reaction: maleate = fumarate. got7fsn_ti maleate cis-trans-isomerase activity MetaCyc:MALEATE-ISOMERASE-RXN|KEGG_REACTION:R01087|EC:5.2.1.1|RHEA:13169 molecular_function owl:Class
GO:0072030 biolink:NamedThing short nephron development The process whose specific outcome is the progression of a short nephron over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb. got7fsn_ti mah 2010-01-25T02:49:32Z biological_process owl:Class
GO:0033941 biolink:NamedThing mannan exo-1,2-1,6-alpha-mannosidase activity Catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose. got7fsn_ti exo-1,2-1,6-alpha-mannosidase activity|1,2-1,6-alpha-D-mannan D-mannohydrolase activity EC:3.2.1.137|MetaCyc:3.2.1.137-RXN molecular_function owl:Class
GO:0009721 biolink:NamedThing detection of auxin stimulus The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of auxin stimulus biological_process owl:Class
GO:0019256 biolink:NamedThing acrylonitrile catabolic process The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers. got7fsn_ti acrylonitrile breakdown|acrylonitrile degradation|acrylonitrile catabolism MetaCyc:P344-PWY biological_process owl:Class
GO:0046413 biolink:NamedThing organomercury catabolic process The chemical reactions and pathways resulting in the breakdown of organomercury compounds, any organic compound containing a mercury atom. got7fsn_ti organomercury degradation|organomercury catabolism|organomercury breakdown biological_process owl:Class
GO:0036279 biolink:NamedThing positive regulation of protein export from nucleus in response to glucose starvation Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose. got7fsn_ti bf 2012-07-11T11:05:20Z biological_process owl:Class
GO:0099506 biolink:NamedThing synaptic vesicle transport along actin filament The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors. got7fsn_ti biological_process owl:Class
GO:0045246 biolink:NamedThing cytosolic tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle. got7fsn_ti tricarboxylic acid cycle enzyme complex|TCA cycle enzyme complex cellular_component owl:Class
GO:0098032 biolink:NamedThing icosahedral viral capsid, collar fiber A fiber attached to the collar structure of some icosahedral viral capsids. got7fsn_ti bm 2012-07-19T15:05:16Z cellular_component owl:Class
GO:0012506 biolink:NamedThing vesicle membrane The lipid bilayer surrounding any membrane-bounded vesicle in the cell. got7fsn_ti NIF_Subcellular:sao1153182838 cellular_component owl:Class
GO:0003177 biolink:NamedThing pulmonary valve development The progression of the pulmonary valve over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-08T11:19:44Z biological_process owl:Class
GO:0048321 biolink:NamedThing axial mesodermal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an axial mesoderm cell. got7fsn_ti axial mesoderm cell differentiation biological_process owl:Class
GO:0097700 biolink:NamedThing vascular endothelial cell response to laminar fluid shear stress Any response to laminar fluid shear stress in a vascular endothelial cell. got7fsn_ti blood vessel endothelial cell response to laminar fluid shear stress pr 2016-01-27T12:42:01Z biological_process owl:Class
GO:0018891 biolink:NamedThing cyclohexanol metabolic process The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent. got7fsn_ti cyclohexanol metabolism UM-BBD_pathwayID:chx biological_process owl:Class
GO:0060208 biolink:NamedThing proestrus The estrous cycle phase in which there is heightened follicular activity. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:1903871 biolink:NamedThing DNA recombinase mediator complex assembly The aggregation, arrangement and bonding together of a set of components to form a DNA recombinase mediator complex. got7fsn_ti DNA recombinase mediator complex formation rb 2015-02-05T23:05:10Z biological_process owl:Class
GO:0052165 biolink:NamedThing symbiont defense to host-produced phytoalexin Any process in which a symbiont modulates the frequency, rate or extent of production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of phytoalexin production in other organism involved in symbiotic interaction|evasion or tolerance of phytoalexins produced by host in response to organism|response to host phytoalexin production|phytoalexin detoxification|evasion or tolerance by symbiont of host-produced phytoalexins|evasion or tolerance of phytoalexins|modulation by symbiont of host phytoalexin production|response to phytoalexin production by other organism involved in symbiotic interaction|host phytoalexin detoxification https://github.com/geneontology/go-ontology/issues/18798 GO:0052061|GO:0052304|GO:0052378|GO:0052549|GO:0052566 biological_process owl:Class
GO:0016640 biolink:NamedThing oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule. got7fsn_ti EC:1.4.2.- molecular_function owl:Class
GO:0046965 biolink:NamedThing retinoid X receptor binding Binding to a retinoid X receptor. got7fsn_ti RXR binding molecular_function owl:Class
GO:0042974 biolink:NamedThing retinoic acid receptor binding Binding to a retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. got7fsn_ti RAR binding molecular_function owl:Class
GO:0005136 biolink:NamedThing interleukin-4 receptor binding Binding to an interleukin-4 receptor. got7fsn_ti IL-4|interleukin-4 receptor ligand molecular_function owl:Class
GO:0033097 biolink:NamedThing amyloplast membrane Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope. got7fsn_ti cellular_component owl:Class
GO:0034233 biolink:NamedThing regulation of cell wall chitin catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cell wall chitin. got7fsn_ti regulation of cell wall chitin catabolism|regulation of cell wall chitin degradation|regulation of cell wall chitin breakdown biological_process owl:Class
GO:0034581 biolink:NamedThing 4-methyloct-2-enoyl-CoA hydratase activity Catalysis of the reaction: 4-methyloct-2-enoyl-CoA + H2O = 3-hydroxy-4-methyloctanoyl-CoA. got7fsn_ti UM-BBD_reactionID:r0925 molecular_function owl:Class
GO:0045543 biolink:NamedThing gibberellin 2-beta-dioxygenase activity Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2. got7fsn_ti gibberellin 2-oxidase activity|gibberellin 2-beta-hydroxylase activity|(gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)|gibberellin 2beta-dioxygenase activity|gibberellin 2beta-hydroxylase activity EC:1.14.11.13|MetaCyc:PWY-102|RHEA:15005 molecular_function owl:Class
GO:0071199 biolink:NamedThing Kv4.1-DPP10 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP10 associated with the channel via interaction with the Kv alpha subunit 4.1. got7fsn_ti Kv4.1-DPPY channel complex mah 2009-11-23T05:17:50Z CORUM:601 cellular_component owl:Class
GO:0048687 biolink:NamedThing positive regulation of sprouting of injured axon Any process that activates, maintains or increases the rate of sprouting of an injured axon. got7fsn_ti up regulation of sprouting of injured axon|upregulation of sprouting of injured axon|up-regulation of sprouting of injured axon|stimulation of sprouting of injured axon|activation of sprouting of injured axon biological_process owl:Class
GO:0048680 biolink:NamedThing positive regulation of axon regeneration Any process that activates, maintains or increases the rate of axon regeneration. got7fsn_ti up-regulation of axon regeneration|stimulation of axon regeneration|activation of axon regeneration|upregulation of axon regeneration|up regulation of axon regeneration biological_process owl:Class
GO:0050120 biolink:NamedThing N-acetylhexosamine 1-dehydrogenase activity Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + NAD(+) = N-acetyl-D-glucosaminate + 2 H(+) + NADH. got7fsn_ti N-acetyl-D-hexosamine dehydrogenase activity|N-acetylhexosamine dehydrogenase activity|N-acetyl-D-hexosamine:NAD+ 1-oxidoreductase activity EC:1.1.1.240|RHEA:23144|KEGG_REACTION:R01202|MetaCyc:N-ACETYLHEXOSAMINE-1-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0004320 biolink:NamedThing oleoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate. got7fsn_ti oleoyl-acyl carrier protein thioesterase activity|oleoyl-ACP hydrolase activity|oleoyl-acyl-carrier-protein hydrolase|oleoyl-[acyl-carrier protein] hydrolase activity|oleoyl-ACP thioesterase activity RHEA:15057|EC:3.1.2.14|MetaCyc:3.1.2.14-RXN|MetaCyc:PWY-5142 molecular_function owl:Class
GO:0072546 biolink:NamedThing EMC complex A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. got7fsn_ti ER membrane protein complex|endoplasmic reticulum membrane protein complex https://github.com/geneontology/go-ontology/issues/20234 Note that this complex used to be thought to be involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane, but newer findings show that this was incorrect. mah 2011-01-19T06:16:53Z cellular_component owl:Class
GO:0140534 biolink:NamedThing endoplasmic reticulum protein-containing complex A protein complex that is part of an endoplasmic reticulum. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19952 pg 2020-10-28T12:14:12Z cellular_component owl:Class
GO:0047491 biolink:NamedThing poly(alpha-L-guluronate) lyase activity Catalysis of the reaction: polysaccharides containing a terminal alpha-L-guluronate group = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing a terminal a-L-guluronate group, to give oligopolysaccharides with 4-deoxy-a-L-erythro-hex-4-enuronosyl groups at their nonreducing ends. got7fsn_ti poly-alpha-L-guluronate lyase activity|guluronate lyase activity|L-guluronate lyase activity|polyguluronate-specific alginate lyase activity|alginase II activity|poly(alpha-L-1,4-guluronide) exo-lyase activity|L-guluronan lyase activity EC:4.2.2.11|MetaCyc:4.2.2.11-RXN molecular_function owl:Class
GO:0140671 biolink:NamedThing ADA complex A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and H2B. In budding yeast shares the histone acetylation (HAT) module of ADA2-GCN5-NGG1-SGF29 with the related SAGA complex. got7fsn_ti ADA histone acetyltransferase complex|scADA|ADA HAT complex|Ada2/Gcn5/Ada3 transcription activator complex https://github.com/geneontology/go-ontology/issues/21335 pg 2021-06-25T11:02:49Z cellular_component owl:Class
GO:1990113 biolink:NamedThing RNA polymerase I assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex. got7fsn_ti RNA Polymerase I complex assembly|DNA-directed RNA polymerase I complex assembly rb 2013-05-31T21:44:41Z biological_process owl:Class
GO:0034060 biolink:NamedThing cyanelle stroma The space enclosed by the double membrane of a cyanelle. got7fsn_ti cellular_component owl:Class
GO:0018294 biolink:NamedThing protein-FAD linkage via S-(8alpha-FAD)-L-cysteine The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine. got7fsn_ti RESID:AA0143 biological_process owl:Class
GO:0008732 biolink:NamedThing L-allo-threonine aldolase activity Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde. got7fsn_ti L-allo-threonine acetaldehyde-lyase activity|LtaA EC:4.1.2.49|MetaCyc:LTAA-RXN|RHEA:26209 molecular_function owl:Class
GO:0002296 biolink:NamedThing T-helper 1 cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis. got7fsn_ti T-helper 1 cell fate commitment|Th1 fate commitment|Th1 cell lineage commitment biological_process owl:Class
GO:0002295 biolink:NamedThing T-helper cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes. got7fsn_ti Thp lineage commitment|Th0 lineage commitment|T-helper cell fate commitment biological_process owl:Class
GO:0002513 biolink:NamedThing tolerance induction to self antigen Tolerance induction directed at self antigens. got7fsn_ti biological_process owl:Class
GO:0008228 biolink:NamedThing opsonization The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. got7fsn_ti Wikipedia:Opsonin biological_process owl:Class
GO:0001838 biolink:NamedThing embryonic epithelial tube formation The morphogenesis of an embryonic epithelium into a tube-shaped structure. got7fsn_ti biological_process owl:Class
GO:1990239 biolink:NamedThing steroid hormone binding Binding to a steroid hormone. got7fsn_ti pr 2013-11-15T09:26:18Z molecular_function owl:Class
GO:0005496 biolink:NamedThing steroid binding Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. got7fsn_ti molecular_function owl:Class
GO:0010882 biolink:NamedThing regulation of cardiac muscle contraction by calcium ion signaling Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction. got7fsn_ti regulation of cardiac muscle contraction by calcium ion signalling biological_process owl:Class
GO:0072742 biolink:NamedThing SAGA complex localization to transcription regulatory region Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene. got7fsn_ti SAGA complex localization to promoter|SAGA complex recruitment mah 2012-08-24T10:36:03Z biological_process owl:Class
GO:0072386 biolink:NamedThing plus-end-directed organelle transport along microtubule The directed movement of an organelle towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. got7fsn_ti microtubule plus-end-directed organelle distribution|microtubule plus-end-directed organelle localization mah 2010-12-01T05:02:09Z biological_process owl:Class
GO:0072384 biolink:NamedThing organelle transport along microtubule The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. got7fsn_ti microtubule-based organelle localization mah 2010-12-01T04:59:11Z biological_process owl:Class
GO:0010960 biolink:NamedThing magnesium ion homeostasis Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell. got7fsn_ti tb 2009-05-06T11:47:17Z biological_process owl:Class
GO:0002268 biolink:NamedThing follicular dendritic cell differentiation The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell. got7fsn_ti biological_process owl:Class
GO:0006311 biolink:NamedThing meiotic gene conversion The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele. got7fsn_ti gene conversion without reciprocal crossover biological_process owl:Class
GO:0004558 biolink:NamedThing alpha-1,4-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. got7fsn_ti glucoinvertase activity|alpha-glucosidase II|acid maltase activity|alpha-glucoside hydrolase activity|maltase-glucoamylase activity|alpha-glucopyranosidase activity|alpha-D-glucosidase activity|alpha-1,4-glucosidase activity|alpha-D-glucoside glucohydrolase activity|lysosomal alpha-glucosidase activity|glucosidoinvertase activity|glucosidosucrase activity GO:0004562|GO:0016982 Reactome:R-HSA-189102|Reactome:R-HSA-5659861|Reactome:R-HSA-189053|MetaCyc:MALTODEXGLUCOSID-RXN|Reactome:R-HSA-191108|Reactome:R-HSA-191116|EC:3.2.1.20|Reactome:R-HSA-5659899|Reactome:R-HSA-5659879|Reactome:R-HSA-191101|Reactome:R-HSA-5659922 molecular_function owl:Class
GO:0097112 biolink:NamedThing gamma-aminobutyric acid receptor clustering The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane. got7fsn_ti GABA receptor clustering pr 2011-07-31T05:21:08Z biological_process owl:Class
GO:0052860 biolink:NamedThing 2'-deoxymugineic-acid 3-dioxygenase activity Catalysis of the reaction: 2'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2'-deoxymugineic acid + succinate + CO2. got7fsn_ti 2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity ai 2011-12-05T06:00:58Z EC:1.14.11.25|MetaCyc:RXN-7983|KEGG_REACTION:R07187|RHEA:20065 molecular_function owl:Class
GO:1990854 biolink:NamedThing vacuole-ER tethering The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles. got7fsn_ti vacuole-ER attachment|vacuole-endoplasmic reticulum attachment|vacuole-endoplasmic reticulum tethering mcc 2015-09-15T18:50:04Z biological_process owl:Class
GO:0051685 biolink:NamedThing maintenance of ER location Any process in which the endoplasmic reticulum is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of endoplasmic reticulum localization|maintenance of ER localization biological_process owl:Class
GO:0034050 biolink:NamedThing programmed cell death induced by symbiont Cell death resulting from activation of endogenous cellular processes after interaction with a symbiont (defined as the smaller of two, or more, organisms engaged in symbiosis, a close interaction encompassing mutualism through parasitism). This can be triggered by direct interaction with the organism, for example, contact with penetrating hyphae of a fungus; or an indirect interaction such as symbiont-secreted molecules. got7fsn_ti 'host programmed cell death induced by symbiont' https://github.com/geneontology/go-ontology/issues/20255 Note that this term is to be used to annotate gene products in the host, not the symbiont. To annotate gene products in the symbiont that induce programmed cell death in the host, consider the biological process term 'positive regulation by symbiont of host programmed cell death ; GO:0052042'. biological_process owl:Class
GO:0004305 biolink:NamedThing ethanolamine kinase activity Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine. got7fsn_ti ethanolamine kinase (phosphorylating)|ethanolamine phosphokinase activity|ATP:ethanolamine O-phosphotransferase activity KEGG_REACTION:R01468|MetaCyc:ETHANOLAMINE-KINASE-RXN|EC:2.7.1.82|Reactome:R-HSA-1483222|RHEA:13069 molecular_function owl:Class
GO:0005619 biolink:NamedThing ascospore wall The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi. got7fsn_ti fungal-type spore wall cellular_component owl:Class
GO:0085001 biolink:NamedThing formation of stylet for nutrient acquisition The assembly of a stylet, a hollow protrusible spear-like symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti formation by symbiont of stylet for nutrient acquisition from host https://github.com/geneontology/go-ontology/issues/20305 jl 2010-02-24T01:49:06Z biological_process owl:Class
GO:0018295 biolink:NamedThing protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine. got7fsn_ti RESID:AA0144 biological_process owl:Class
GO:0000432 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter. got7fsn_ti stimulation of transcription from RNA polymerase II promoter by glucose|activation of transcription from RNA polymerase II promoter by glucose|upregulation of transcription from RNA polymerase II promoter by glucose|up-regulation of transcription from RNA polymerase II promoter by glucose|up regulation of transcription from RNA polymerase II promoter by glucose biological_process owl:Class
GO:0030793 biolink:NamedThing 3'-demethylstaurosporine O-methyltransferase activity Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine. got7fsn_ti staurosporine synthase activity|3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity|S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity EC:2.1.1.139|RHEA:11696|KEGG_REACTION:R05757|MetaCyc:2.1.1.139-RXN molecular_function owl:Class
GO:0000429 biolink:NamedThing carbon catabolite regulation of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. got7fsn_ti regulation of transcription from RNA polymerase II promoter by carbon catabolites biological_process owl:Class
GO:0071757 biolink:NamedThing hexameric IgM immunoglobulin complex A circulating form of IgM consisting of a hexamer of IgM core units with a single J chain polypeptide. got7fsn_ti hexameric IgM antibody Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0071754 biolink:NamedThing IgM immunoglobulin complex, circulating A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph. got7fsn_ti IgM antibody Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0016664 biolink:NamedThing oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein. got7fsn_ti oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor EC:1.7.7.- molecular_function owl:Class
GO:0050178 biolink:NamedThing phenylpyruvate tautomerase activity Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate. got7fsn_ti phenylpyruvate keto-enol-isomerase activity|phenylpyruvate keto--enol tautomerase activity|phenylpyruvic keto--enol isomerase activity RHEA:17097|MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN|EC:5.3.2.1 molecular_function owl:Class
GO:0051945 biolink:NamedThing negative regulation of catecholamine uptake involved in synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. got7fsn_ti down regulation of catecholamine uptake during transmission of nerve impulse|negative regulation of catecholamine neurotransmitter uptake|negative regulation of catecholamine neurotransmitter reuptake|negative regulation of catecholamine uptake during transmission of nerve impulse|down-regulation of catecholamine uptake during transmission of nerve impulse|downregulation of catecholamine uptake during transmission of nerve impulse|inhibition of catecholamine uptake during transmission of nerve impulse biological_process owl:Class
GO:0052739 biolink:NamedThing phosphatidylserine 1-acylhydrolase activity Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid. got7fsn_ti phosphatidylserine-specific phospholipase A1 activity EC:3.1.1.32|KEGG_REACTION:R04034|Reactome:R-HSA-8869425 molecular_function owl:Class
GO:0120243 biolink:NamedThing 2-iminopropanoate deaminase activity Catalysis of the reaction: 2-iminopropanoate + H2O = NH4(+) + pyruvate. got7fsn_ti 2-iminobutanoate/2-iminopropanoate deaminase https://github.com/geneontology/go-ontology/issues/19832 krc 2020-07-29T19:41:18Z KEGG_REACTION:R11099|MetaCyc:RXN-15127|RHEA:40671 molecular_function owl:Class
GO:0072231 biolink:NamedThing metanephric proximal convoluted tubule segment 1 development The process whose specific outcome is the progression of the S1 portion of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The S1 portion is the initial portion of the metanephric proximal convoluted tubule and is responsible for avid reabsorption of water and solutes. got7fsn_ti metanephric S1 development mah 2010-03-18T03:39:10Z biological_process owl:Class
GO:0035079 biolink:NamedThing polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals. got7fsn_ti biological_process owl:Class
GO:0047973 biolink:NamedThing guanidinoacetate kinase activity Catalysis of the reaction: ATP + guanidinoacetate = ADP + 2 H(+) + phosphoguanidinoacetate. got7fsn_ti glycocyamine kinase activity|ATP:guanidinoacetate N-phosphotransferase activity|guanidoacetate kinase activity MetaCyc:GUANIDOACETATE-KINASE-RXN|KEGG_REACTION:R02575|EC:2.7.3.1|RHEA:14145 molecular_function owl:Class
GO:0060425 biolink:NamedThing lung morphogenesis The process in which the anatomical structures of the lung are generated and organized. got7fsn_ti biological_process owl:Class
GO:0044418 biolink:NamedThing translocation of DNA into host The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti transport of DNA into other organism during symbiotic interaction|transport of DNA into host|translocation of DNA into other organism during symbiotic interaction|translocation of DNA into other organism involved in symbiotic interaction GO:0051837 biological_process owl:Class
GO:0043823 biolink:NamedThing spheroidene monooxygenase activity Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O. got7fsn_ti RHEA:33027|EC:1.14.15.9|MetaCyc:RXN-10670 molecular_function owl:Class
GO:0019310 biolink:NamedThing inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. got7fsn_ti myo-inositol catabolic process|inositol degradation|inositol catabolism|inositol breakdown|vitamin Bh catabolic process|vitamin Bh catabolism|myo-inositol catabolism MetaCyc:P562-PWY biological_process owl:Class
GO:0036524 biolink:NamedThing protein deglycase activity Catalysis of the removal of a sugar or dicarbonyl from a lysine residue of a glycated protein. got7fsn_ti protein deglycating enzyme bf 2016-08-04T10:23:33Z MetaCyc:RXN-17634|MetaCyc:RXN-17630|MetaCyc:RXN-17632 molecular_function owl:Class
GO:0060219 biolink:NamedThing camera-type eye photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye. got7fsn_ti biological_process owl:Class
GO:0022037 biolink:NamedThing metencephalon development The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0052917 biolink:NamedThing dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol. got7fsn_ti dolichyl-P-mannose:Man(7)GlcNAc(2)-PP-dolichyl mannosyltransferase activity|dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity|dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity https://github.com/geneontology/go-ontology/issues/19075 GO:0052824 EC:2.4.1.260|RHEA:29535|MetaCyc:RXN-5468|KEGG_REACTION:R06260 molecular_function owl:Class
GO:0140624 biolink:NamedThing EGAD pathway The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21085 pg 2021-03-12T10:41:58Z biological_process owl:Class
GO:0034477 biolink:NamedThing U6 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U6 snRNA molecule. got7fsn_ti U6 snRNA 3' end processing biological_process owl:Class
GO:0003980 biolink:NamedThing UDP-glucose:glycoprotein glucosyltransferase activity Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. got7fsn_ti UGGT activity Reactome:R-HSA-548884 molecular_function owl:Class
GO:0090333 biolink:NamedThing regulation of stomatal closure Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. got7fsn_ti tb 2010-05-26T02:14:49Z biological_process owl:Class
GO:0010119 biolink:NamedThing regulation of stomatal movement Any process that modulates the frequency, rate or extent of stomatal movement. got7fsn_ti biological_process owl:Class
GO:0051472 biolink:NamedThing glucosylglycerol metabolic process The chemical reactions and pathways involving glucosylglycerol, alpha-D-glucopyranosyl-alpha-(1,2)-glycerol. got7fsn_ti glucosylglycerol metabolism biological_process owl:Class
GO:0034260 biolink:NamedThing negative regulation of GTPase activity Any process that stops or reduces the rate of GTP hydrolysis by a GTPase. got7fsn_ti downregulation of Rab GTPase activity|down regulation of Rab GTPase activity|downregulation of GTPase activity|down regulation of Ras GTPase activity|down-regulation of Rab GTPase activity|down-regulation of Ras GTPase activity|inhibition of Rab GTPase activity|inhibition of regulation of Ran GTPase activity|inhibition of GTPase activity|inhibition of Rho GTPase activity|inhibition of Ras GTPase activity|downregulation of regulation of Ran GTPase activity|down regulation of GTPase activity|down regulation of regulation of Ran GTPase activity|downregulation of Ras GTPase activity|down-regulation of Rho GTPase activity|downregulation of Rho GTPase activity|negative regulation of Ras GTPase activity|negative regulation of guanosinetriphosphatase activity|negative regulation of Ran GTPase activity|down regulation of Rho GTPase activity|negative regulation of Rho GTPase activity|negative regulation of Rab GTPase activity|down-regulation of GTPase activity|down-regulation of regulation of Ran GTPase activity An example of this is P2xA in Dictyostelium (UniProt symbol Q86JM7) in PMID:24335649. GO:0034259|GO:0034261|GO:1902264|GO:1902881 biological_process owl:Class
GO:0034446 biolink:NamedThing substrate adhesion-dependent cell spreading The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. got7fsn_ti cell spreading during cell substrate adhesion|substrate adhesion dependent cell spreading biological_process owl:Class
GO:0060988 biolink:NamedThing lipid tube assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as they fuse or undergo fission. got7fsn_ti lipid tubulation dph 2010-01-11T01:56:59Z biological_process owl:Class
GO:0032944 biolink:NamedThing regulation of mononuclear cell proliferation Any process that modulates the frequency, rate or extent of mononuclear cell proliferation. got7fsn_ti regulation of peripheral blood mononuclear cell proliferation|regulation of PBMC proliferation biological_process owl:Class
GO:0102134 biolink:NamedThing (22S)-22-hydroxy-campesterol C-23 hydroxylase activity Catalysis of the reaction: H+ + (22S)-22-hydroxycampesterol + NADPH + O2 <=> (22R,23R)-22,23-dihydroxycampesterol + NADP + H2O. got7fsn_ti MetaCyc:RXN-11529 molecular_function owl:Class
GO:0003747 biolink:NamedThing translation release factor activity Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. got7fsn_ti GO:0003749|GO:0003748 molecular_function owl:Class
GO:0045498 biolink:NamedThing sex comb development The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg. got7fsn_ti biological_process owl:Class
GO:0071349 biolink:NamedThing cellular response to interleukin-12 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus. got7fsn_ti cellular response to IL-12 mah 2009-12-11T02:49:40Z biological_process owl:Class
GO:0034809 biolink:NamedThing benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2. got7fsn_ti UM-BBD_reactionID:r1127 molecular_function owl:Class
GO:0043911 biolink:NamedThing D-lysine transaminase activity Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate. got7fsn_ti D-lysine aminotransferase activity molecular_function owl:Class
GO:0050882 biolink:NamedThing voluntary musculoskeletal movement The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will. got7fsn_ti biological_process owl:Class
GO:0035974 biolink:NamedThing meiotic spindle pole body The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome. got7fsn_ti bf 2011-08-16T11:37:59Z cellular_component owl:Class
GO:0010408 biolink:NamedThing fasciclin-like arabinogalactan protein metabolic process The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain. got7fsn_ti fasciclin-like arabinogalactan protein metabolism biological_process owl:Class
GO:0035696 biolink:NamedThing monocyte extravasation The migration of a monocyte from the blood vessels into the surrounding tissue. got7fsn_ti bf 2011-02-28T03:05:52Z biological_process owl:Class
GO:0048824 biolink:NamedThing pigment cell precursor differentiation The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor. got7fsn_ti chromatophore precursor differentiation biological_process owl:Class
GO:0000430 biolink:NamedThing regulation of transcription from RNA polymerase II promoter by glucose Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti biological_process owl:Class
GO:0090304 biolink:NamedThing nucleic acid metabolic process Any cellular metabolic process involving nucleic acids. got7fsn_ti tb 2010-04-07T10:18:47Z biological_process owl:Class
GO:0033515 biolink:NamedThing L-lysine catabolic process using lysine 6-aminotransferase The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including alpha-aminoadipate; in this pathway, L-lysine is converted to 2-aminoadipate-6-semialdehyde by lysine 6-aminotransferase. got7fsn_ti L-lysine breakdown using lysine 6-aminotransferase|L-lysine degradation using lysine 6-aminotransferase MetaCyc:PWY-5298 biological_process owl:Class
GO:0007124 biolink:NamedThing pseudohyphal growth The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli. got7fsn_ti biological_process owl:Class
GO:1990823 biolink:NamedThing response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. got7fsn_ti response to LIF|response to cholinergic differentiation factor|response to CDF sl 2015-08-19T16:44:21Z biological_process owl:Class
GO:0042970 biolink:NamedThing homoserine transmembrane transporter activity Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine. got7fsn_ti homoserine transporter activity molecular_function owl:Class
GO:0019786 biolink:NamedThing Atg8-specific protease activity Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier. got7fsn_ti APG8-PE hydrolase|APG8-specific protease activity molecular_function owl:Class
GO:2000640 biolink:NamedThing positive regulation of SREBP signaling pathway Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway. got7fsn_ti positive regulation of SREBP-mediated signaling pathway|positive regulation of SREBP-mediated signalling pathway vk 2011-04-20T02:46:05Z biological_process owl:Class
GO:0048842 biolink:NamedThing positive regulation of axon extension involved in axon guidance Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance. got7fsn_ti up-regulation of axon extension involved in axon guidance|stimulation of axon extension involved in axon guidance|activation of axon extension involved in axon guidance|up regulation of axon extension involved in axon guidance|upregulation of axon extension involved in axon guidance biological_process owl:Class
GO:0050921 biolink:NamedThing positive regulation of chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. got7fsn_ti activation of chemotaxis|stimulation of chemotaxis|up regulation of chemotaxis|up-regulation of chemotaxis|upregulation of chemotaxis biological_process owl:Class
GO:0051904 biolink:NamedThing pigment granule transport The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti pigment granule translocation biological_process owl:Class
GO:1990110 biolink:NamedThing callus formation The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate. got7fsn_ti tb 2013-05-29T22:02:52Z biological_process owl:Class
GO:0099124 biolink:NamedThing axonal dopamine secretion The regulated release of dopamine from an axon. got7fsn_ti axonal DA release|axonal dopamine release biological_process owl:Class
GO:0051564 biolink:NamedThing positive regulation of smooth endoplasmic reticulum calcium ion concentration Any process that increases the concentration of calcium ions in the smooth endoplasmic reticulum. got7fsn_ti smooth endoplasmic reticulum calcium ion concentration elevation|elevation of smooth endoplasmic reticulum calcium ion concentration|elevation of calcium ion concentration in smooth endoplasmic reticulum|elevation of smooth ER calcium ion concentration biological_process owl:Class
GO:0016233 biolink:NamedThing telomere capping A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins. got7fsn_ti telomere end protection biological_process owl:Class
GO:0016603 biolink:NamedThing glutaminyl-peptide cyclotransferase activity Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3. got7fsn_ti glutaminyl cyclase activity|glutaminyl-tRNA cyclotransferase activity|glutaminyl-transfer ribonucleate cyclotransferase activity|L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing) RHEA:23652|MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN|EC:2.3.2.5 molecular_function owl:Class
GO:0033098 biolink:NamedThing amyloplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma. got7fsn_ti cellular_component owl:Class
GO:0002682 biolink:NamedThing regulation of immune system process Any process that modulates the frequency, rate, or extent of an immune system process. got7fsn_ti biological_process owl:Class
GO:0032867 biolink:NamedThing L-arabinose:NADP reductase activity Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+. got7fsn_ti arabinose reductase activity|arabinose:NADP reductase activity KEGG_REACTION:R01759|RHEA:25229|SABIO-RK:1858|MetaCyc:RXN-8772 molecular_function owl:Class
GO:0071933 biolink:NamedThing Arp2/3 complex binding Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). got7fsn_ti mah 2010-09-29T02:48:41Z molecular_function owl:Class
GO:1990840 biolink:NamedThing response to lectin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties. got7fsn_ti This term refers to endogenous (evolved) responses to lectins (endogenous or exogenous), it does not cover the events that happen due to lectin toxicity. sl 2015-08-27T20:02:21Z biological_process owl:Class
GO:0033928 biolink:NamedThing mannan 1,4-mannobiosidase activity Catalysis of the hydrolysis of (1->4)-beta-D-mannosidic linkages in (1->4)-beta-D-mannans, to remove successive mannobiose residues from the non-reducing chain ends. got7fsn_ti exo-1,4-beta-mannobiohydrolase activity|exo-beta-mannanase activity|mannan 1,4-beta-mannobiosidase activity|1,4-beta-D-mannan mannobiohydrolase activity EC:3.2.1.100|MetaCyc:3.2.1.100-RXN molecular_function owl:Class
GO:0039009 biolink:NamedThing rectal diverticulum development The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior. got7fsn_ti pronephric rectal diverticulum development bf 2010-07-02T09:48:58Z biological_process owl:Class
GO:0016768 biolink:NamedThing spermine synthase activity Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. got7fsn_ti spermine synthetase activity|S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity|spermidine aminopropyltransferase activity Reactome:R-HSA-351210|EC:2.5.1.22|MetaCyc:SPERMINE-SYNTHASE-RXN|RHEA:19973 molecular_function owl:Class
GO:0023022 biolink:NamedThing termination of T cell signal transduction The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated. got7fsn_ti 2010-02-16T09:30:50Z biological_process owl:Class
GO:0031172 biolink:NamedThing ornithine N5-monooxygenase activity Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O. got7fsn_ti L-ornithine 5-monooxygenase activity RHEA:41508|MetaCyc:RXN-11128 molecular_function owl:Class
GO:0048317 biolink:NamedThing seed morphogenesis The process in which the anatomical structures of the seed are generated and organized. got7fsn_ti biological_process owl:Class
GO:0102218 biolink:NamedThing starch, H2O dikinase activity Catalysis of the reaction: n ATP + n H2O + starch = n AMP + n hydrogenphosphate + a 6-phosphogluco-amylopectin. got7fsn_ti EC:2.7.9.4|MetaCyc:RXN-12203 molecular_function owl:Class
GO:0050521 biolink:NamedThing alpha-glucan, water dikinase activity Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate. got7fsn_ti starch-related R1 protein activity|alpha-glucan,water dikinase activity|GWD|a-glucan, water dikinase activity|ATP:alpha-glucan, water phosphotransferase activity MetaCyc:2.7.9.4-RXN|EC:2.7.9.4|RHEA:11668 molecular_function owl:Class
GO:0018624 biolink:NamedThing toluene dioxygenase activity Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+). got7fsn_ti toluene 1,2-dioxygenase activity|toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)|toluene 2,3-dioxygenase activity KEGG_REACTION:R03559|EC:1.14.12.11|MetaCyc:TOLUENE-DIOXYGENASE-RXN|RHEA:16737|UM-BBD_enzymeID:e0155 molecular_function owl:Class
GO:0080149 biolink:NamedThing sucrose induced translational repression Any process that stops, prevents or reduces the rate of translation as a result of increase in sucrose level. got7fsn_ti negative regulation of translation in response to sucrose dhl 2010-03-26T04:13:15Z biological_process owl:Class
GO:0032055 biolink:NamedThing negative regulation of translation in response to stress Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress. got7fsn_ti down-regulation of translation in response to stress|inhibition of translation in response to stress|downregulation of translation in response to stress|down regulation of translation in response to stress biological_process owl:Class
GO:0038088 biolink:NamedThing VEGF-activated platelet-derived growth factor receptor-beta signaling pathway A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGF-A/PDGFRbeta signaling|VEGF-activated PDGFRbeta signalling pathway|VEGF/PDGFRbeta signaling pathway|VEGF-activated platelet-derived growth factor receptor-beta signalling pathway|vascular endothelial growth factor-activated platelet-derived growth factor receptor-beta signaling pathway bf 2012-02-01T03:10:16Z biological_process owl:Class
GO:0035791 biolink:NamedThing platelet-derived growth factor receptor-beta signaling pathway A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti PDGFR-beta signaling pathway|betaPDGF receptor signaling pathway|platelet-derived growth factor receptor-beta signalling pathway|PDGF receptor-beta signaling pathway bf 2011-04-06T10:57:04Z biological_process owl:Class
GO:0102787 biolink:NamedThing caffeoyl-CoA:pelargonidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-beta-D-caffeoylglucoside + coenzyme A. got7fsn_ti MetaCyc:RXN-7997 molecular_function owl:Class
GO:0018836 biolink:NamedThing alkylmercury lyase activity Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+. got7fsn_ti organomercurial lyase activity|alkylmercury mercuric-lyase (alkane-forming)|alkylmercury mercuric-lyase activity|organomercury lyase activity EC:4.99.1.2|MetaCyc:ALKYLMERCURY-LYASE-RXN|UM-BBD_enzymeID:e0055|RHEA:18777 molecular_function owl:Class
GO:0098924 biolink:NamedThing retrograde trans-synaptic signaling by nitric oxide Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. got7fsn_ti biological_process owl:Class
GO:0060423 biolink:NamedThing foregut regionalization The pattern specification process that results in the spatial subdivision of an axis or axes along the foregut to define an area or volume in which specific patterns of cell differentiation will take place. got7fsn_ti biological_process owl:Class
GO:0103041 biolink:NamedThing thiosulfate-thioredoxin sulfurtransferase activity Catalysis of the reaction: hydroxidodioxidosulfidosulfate + a reduced thioredoxin = sulfite + hydrogen sulfide + H+ + an oxidized thioredoxin. got7fsn_ti MetaCyc:RXN0-6385 molecular_function owl:Class
GO:0030159 biolink:NamedThing signaling receptor complex adaptor activity The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. got7fsn_ti receptor signaling complex scaffold protein activity|receptor signaling complex scaffold activity|receptor signalling complex adaptor activity|receptor signaling complex adaptor activity|receptor signalling complex scaffold activity molecular_function owl:Class
GO:0034266 biolink:NamedThing isopentenyl adenine catabolic process The chemical reactions and pathways resulting in the breakdown of the cytokinin 6-isopentenyladenine. got7fsn_ti isopentenyl adenine breakdown|isopentenyl adenine catabolism|isopentenyl adenine degradation|isopentenyladenine catabolic process biological_process owl:Class
GO:0009823 biolink:NamedThing cytokinin catabolic process The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators. got7fsn_ti cytokinin catabolism|cytokinin degradation|cytokinin breakdown biological_process owl:Class
GO:0047136 biolink:NamedThing 4-(dimethylamino)phenylazoxybenzene reductase activity Catalysis of the reaction: 4-(dimethylamino)azobenzene + H(2)O + NADP(+) = 4-(dimethylamino)phenylazoxybenzene + H(+) + NADPH. got7fsn_ti dimethylaminoazobenzene N-oxide reductase activity|N,N-dimethyl-p-aminoazobenzene oxide reductase activity|NADPH2:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity|NADPH:4-(dimethylamino)phenylazoxybenzene oxidoreductase activity|4-(dimethylamino)phenylazobenzene:NADP+ oxidoreductase activity|NADPH-dependent DMAB N-oxide reductase activity RHEA:19789|MetaCyc:1.6.6.12-RXN|EC:1.7.1.11|KEGG_REACTION:R04303 molecular_function owl:Class
GO:1990453 biolink:NamedThing nucleosome disassembly/reassembly complex A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex. got7fsn_ti eaf5/7/3 complex An example of this is EAF7 in Saccharomyces cerevisiae (P53911) in PMID:24843044 (inferred from direct assay). bhm 2014-08-08T15:18:30Z cellular_component owl:Class
GO:0046016 biolink:NamedThing positive regulation of transcription by glucose Any process involving glucose that activates or increases the rate of transcription. got7fsn_ti upregulation of transcription by glucose|stimulation of transcription by glucose|activation of transcription by glucose|up-regulation of transcription by glucose|up regulation of transcription by glucose biological_process owl:Class
GO:0000112 biolink:NamedThing nucleotide-excision repair factor 3 complex One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p). got7fsn_ti NEF3 complex Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. cellular_component owl:Class
GO:0097212 biolink:NamedThing lysosomal membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. got7fsn_ti lysosomal membrane organisation|lysosome membrane organization pr 2012-01-12T10:16:15Z biological_process owl:Class
GO:0070213 biolink:NamedThing protein auto-ADP-ribosylation The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. got7fsn_ti protein amino acid auto-ADP-ribosylation biological_process owl:Class
GO:0052771 biolink:NamedThing coenzyme F390-G hydrolase activity Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420. got7fsn_ti 8-hydroxyguanylylated-coenzyme F420 hydrolase activity ai 2011-10-03T12:00:00Z molecular_function owl:Class
GO:0086069 biolink:NamedThing bundle of His cell to Purkinje myocyte communication The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti atrioventricular junction myocyte to bundle branch myocyte|bundle branch myocyte to Purkinje myocyte communication|bundle of His cardiac muscle cell to Purkinje myocyte communication|ventricular conduction system cell to cell communication|bundle of His myocyte to atrioventricular junction myocyte https://github.com/geneontology/go-ontology/issues/20731 dph 2011-11-22T09:18:49Z biological_process owl:Class
GO:0007539 biolink:NamedThing primary sex determination, soma The transmission of information about sexual status from the initial, general, determination to signals specific to the soma. got7fsn_ti biological_process owl:Class
GO:0007538 biolink:NamedThing primary sex determination The sex determination process that results in the initial specification of sexual status of an individual organism. got7fsn_ti biological_process owl:Class
GO:0002542 biolink:NamedThing Factor XII activation Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade. got7fsn_ti Hageman factor activation biological_process owl:Class
GO:0080024 biolink:NamedThing indolebutyric acid metabolic process The chemical reactions and pathways involving indolebutyric acid, a compound that serves as an active or storage form of the hormone indole-3-acetic acid (an auxin) in many plants. got7fsn_ti IBA metabolism|indole-3-butyric acid metabolic process|IBA metabolic process biological_process owl:Class
GO:0099009 biolink:NamedThing viral genome circularization The circularization of a viral genome following infection of a host cell. This is common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome. It can be mediated by covalent closure of the DNA sticky ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities. got7fsn_ti VZ:3968 biological_process owl:Class
GO:0070097 biolink:NamedThing delta-catenin binding Binding to the delta subunit of the catenin complex. got7fsn_ti molecular_function owl:Class
GO:0099071 biolink:NamedThing dynamic microtubule bundle A microtubule bundle that undergoes changes in length, and in which microtubule sliding takes place. got7fsn_ti cellular_component owl:Class
GO:0051912 biolink:NamedThing CoB--CoM heterodisulfide reductase activity Catalysis of the reaction: coenzyme B + coenzyme M + methanophenazine = N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine + dihydromethanophenazine. got7fsn_ti coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity|heterodisulfide reductase activity|soluble heterodisulfide reductase activity|coenzyme B:coenzyme M:methanophenazine oxidoreductase activity|CoB-CoM heterodisulfide reductase activity|coenzyme B--coenzyme M heterodisulfide reductase activity EC:1.8.98.1|RHEA:18085|MetaCyc:1.8.98.1-RXN molecular_function owl:Class
GO:0043577 biolink:NamedThing chemotropism The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it. got7fsn_ti Wikipedia:Chemotropism biological_process owl:Class
GO:0016420 biolink:NamedThing malonyltransferase activity Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0039585 biolink:NamedThing PKR-mediated signaling A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK3), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation. got7fsn_ti EIF2AK3/PERK signaling|signaling through PKR|PKR signaling pathway|EIF2AK3 signal transduction|PKR signal transduction bf 2012-05-02T04:15:10Z biological_process owl:Class
GO:0120049 biolink:NamedThing snRNA (adenine-N6)-methylation The posttranscriptional N6-methylation of an adenine residue in an snRNA molecule. got7fsn_ti krc 2017-06-02T20:56:51Z biological_process owl:Class
GO:0040031 biolink:NamedThing snRNA modification The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA. got7fsn_ti biological_process owl:Class
GO:0015328 biolink:NamedThing cystine secondary active transmembrane transporter activity Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti lysosomal cystine transporter|cystine porter activity|cystinosin molecular_function owl:Class
GO:0005294 biolink:NamedThing neutral L-amino acid secondary active transmembrane transporter activity Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti neutral L-amino acid porter activity molecular_function owl:Class
GO:0048244 biolink:NamedThing phytanoyl-CoA dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + O(2) + phytanoyl-CoA = 2-hydroxyphytanoyl-CoA + CO(2) + succinate. got7fsn_ti phytanoyl-CoA 2-hydroxylase activity|phytanoyl-CoA 2 oxoglutarate dioxygenase activity|phytanoyl-CoA alpha-hydroxylase activity|phytanoyl-CoA hydroxylase activity|phytanoyl-CoA, 2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) MetaCyc:1.14.11.18-RXN|RHEA:16065|EC:1.14.11.18|Reactome:R-HSA-389639|KEGG_REACTION:R05722 molecular_function owl:Class
GO:0090597 biolink:NamedThing nematode male tail mating organ morphogenesis The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules. got7fsn_ti tb 2014-08-22T13:25:22Z biological_process owl:Class
GO:0033621 biolink:NamedThing nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts The chemical reactions and pathways resulting in the selective degradation of meiosis-specific transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein. got7fsn_ti mRNA degradation, meiosis-specific transcripts|mRNA catabolism, meiosis-specific transcripts|mRNA breakdown, meiosis-specific transcripts|degradation of meiosis-specific transcripts|nuclear mRNA catabolic process, meiosis-specific transcripts Note that it is speculated that higher eukaryotic YTH-family protein may be involved in similar mechanisms to supress gene regulation during gametogenesis or general silencing. biological_process owl:Class
GO:0016607 biolink:NamedThing nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. got7fsn_ti nuclear speckles|nuclear speckle|speckle focus|speckle domain|splicing speckle cellular_component owl:Class
GO:0018237 biolink:NamedThing urease activator activity Increases the activity of urease by promoting the incorporation of nickel into the active site. got7fsn_ti urease activase activity molecular_function owl:Class
GO:0071724 biolink:NamedThing response to diacyl bacterial lipopeptide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diacylated bacterial lipopeptide stimulus. got7fsn_ti response to diacylated bacterial lipoprotein Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. mah 2010-03-17T02:14:41Z biological_process owl:Class
GO:0048314 biolink:NamedThing embryo sac morphogenesis The process in which the anatomical structures of the embryo sac are generated and organized. The embryo sac develops from the megaspore in heterosporous plants. got7fsn_ti female gametophyte morphogenesis biological_process owl:Class
GO:0097073 biolink:NamedThing interferon regulatory factor 5 complex An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5. got7fsn_ti IRF5:IRF5 complex pr 2011-06-15T04:28:57Z cellular_component owl:Class
GO:0052861 biolink:NamedThing glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. got7fsn_ti laminarinase activity|laminaranase activity|1,3-(1,3)-beta-D-glucan 3-glucanohydrolase activity ai 2011-12-06T04:49:36Z EC:3.2.1.6|MetaCyc:3.2.1.6-RXN molecular_function owl:Class
GO:0052736 biolink:NamedThing beta-glucanase activity Catalysis of the hydrolysis of linkages in beta-D-glucans; beta-glucans are polysaccharides of D-glucose monomers linked by beta-glycosidic bonds. got7fsn_ti beta-D-glucanase activity 2011-08-19T03:40:56Z molecular_function owl:Class
GO:0034396 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter in response to iron Any process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus. got7fsn_ti down regulation of transcription from RNA polymerase II promoter in response to iron|down-regulation of transcription from RNA polymerase II promoter in response to iron|downregulation of transcription from RNA polymerase II promoter in response to iron|inhibition of transcription from RNA polymerase II promoter in response to iron|negative regulation of transcription from Pol II promoter in response to iron biological_process owl:Class
GO:0031567 biolink:NamedThing mitotic cell size control checkpoint signaling A signal transduction process that contributes to a cell size control checkpoint during mitosis. got7fsn_ti mitotic cell size control checkpoint|mitotic cell cycle cell size control checkpoint|signal transduction involved in cell size control checkpoint GO:0072471 biological_process owl:Class
GO:0047099 biolink:NamedThing CDP-4-dehydro-6-deoxyglucose reductase activity Catalysis of the reaction: H2O + NAD(P)+ + CDP-4-dehydro-3,6-dideoxy-D-glucose = NAD(P)H + CDP-4-dehydro-6-deoxy-D-glucose. got7fsn_ti NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase activity|cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase activity|CDP-4-keto-deoxy-glucose reductase activity|CDP-4-keto-6-deoxyglucose reductase activity|CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system activity|cytidine diphospho-4-keto-6-deoxy-D-glucose reductase activity|CDP-4-dehydro-3,6-dideoxy-D-glucose:NAD(P)+ 3-oxidoreductase activity EC:1.17.1.1|MetaCyc:1.17.1.1-RXN molecular_function owl:Class
GO:0010079 biolink:NamedThing maintenance of vegetative meristem identity The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate. got7fsn_ti biological_process owl:Class
GO:0106030 biolink:NamedThing neuron projection fasciculation The collection of neuronal projections into a bundle of rods, known as a fascicle. got7fsn_ti hjd 2017-06-26T19:43:23Z biological_process owl:Class
GO:0050747 biolink:NamedThing positive regulation of lipoprotein metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. got7fsn_ti stimulation of lipoprotein metabolic process|up-regulation of lipoprotein metabolic process|activation of lipoprotein metabolic process|upregulation of lipoprotein metabolic process|positive regulation of lipoprotein metabolism|up regulation of lipoprotein metabolic process biological_process owl:Class
GO:0043717 biolink:NamedThing 2-hydroxyglutaryl-CoA dehydratase activity Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA. got7fsn_ti (R)-2-hydroxyglutaryl-CoA dehydratase activity MetaCyc:RXN-1083|RHEA:42448 molecular_function owl:Class
GO:0031849 biolink:NamedThing olfactory receptor binding Binding to an olfactory receptor. got7fsn_ti olfactory receptor ligand molecular_function owl:Class
GO:0010365 biolink:NamedThing positive regulation of ethylene biosynthetic process Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process. got7fsn_ti biological_process owl:Class
GO:0031337 biolink:NamedThing positive regulation of sulfur amino acid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. got7fsn_ti upregulation of sulfur amino acid metabolic process|up regulation of sulfur amino acid metabolic process|up-regulation of sulfur amino acid metabolic process|positive regulation of sulfur amino acid metabolism|stimulation of sulfur amino acid metabolic process|activation of sulfur amino acid metabolic process biological_process owl:Class
GO:0070722 biolink:NamedThing Tle3-Aes complex A transcriptional repressor complex that consists of a heterodimer of the proteins Tle3 (also known as Grg3b) and Aes (Grg5), which are homologs of the Drosophila groucho gene product. got7fsn_ti Grg3b-Grg5 complex mah 2009-06-10T05:45:28Z cellular_component owl:Class
GO:0042105 biolink:NamedThing alpha-beta T cell receptor complex A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein. got7fsn_ti alpha-beta T lymphocyte receptor complex|alpha-beta TCR complex|alpha-beta T-lymphocyte receptor complex|alpha-beta T-cell receptor complex cellular_component owl:Class
GO:0072441 biolink:NamedThing response to meiotic DNA replication checkpoint signaling A process that occurs in response to signals generated as a result of meiotic DNA replication checkpoint signaling. got7fsn_ti response to signal involved in meiotic DNA replication checkpoint|meiotic DNA replication checkpoint effector process mah 2010-12-08T04:59:26Z biological_process owl:Class
GO:0018807 biolink:NamedThing 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA. got7fsn_ti EC:3.7.1.21|UM-BBD_reactionID:r0204|RHEA:39651 molecular_function owl:Class
GO:0021757 biolink:NamedThing caudate nucleus development The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain. got7fsn_ti biological_process owl:Class
GO:0034457 biolink:NamedThing Mpp10 complex A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p. got7fsn_ti Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. cellular_component owl:Class
GO:0007042 biolink:NamedThing lysosomal lumen acidification Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion. got7fsn_ti lysosome pH reduction biological_process owl:Class
GO:0070866 biolink:NamedThing sterol-dependent protein binding Binding to a protein or protein complex in the presence of sterols. got7fsn_ti mah 2009-08-19T01:43:35Z molecular_function owl:Class
GO:0140608 biolink:NamedThing cysteine-type endopeptidase activator activity Binds to and increases the activity of a cysteine-type endopeptidase. got7fsn_ti caspase activator activator activity https://github.com/geneontology/go-ontology/issues/20916 pg 2021-02-18T08:58:58Z molecular_function owl:Class
GO:0061133 biolink:NamedThing endopeptidase activator activity Binds to and increases the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. got7fsn_ti dph 2010-05-17T01:08:29Z molecular_function owl:Class
GO:0071815 biolink:NamedThing intermediate-density lipoprotein particle binding Binding to a intermediate-density lipoprotein particle, a triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. got7fsn_ti IDL binding|intermediate-density lipoprotein binding mah 2010-09-06T04:28:35Z molecular_function owl:Class
GO:0080026 biolink:NamedThing response to indolebutyric acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus. got7fsn_ti response to indolebutyric acid stimulus|response to indole-3-butyric acid stimulus|response to IBA stimulus biological_process owl:Class
GO:1990959 biolink:NamedThing eosinophil homeostasis The process of regulating the proliferation and elimination of eosinophils such that the total number of eosinophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti eosinophilic granulocyte homeostasis|eosinophilic leucocyte homeostasis|eosinophilic leukocyte homeostasis|eosinocyte homeostasis sl 2016-06-06T22:34:31Z biological_process owl:Class
GO:0000010 biolink:NamedThing trans-hexaprenyltranstransferase activity Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate. got7fsn_ti RHEA:20836 molecular_function owl:Class
GO:0030253 biolink:NamedThing protein secretion by the type I secretion system The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. got7fsn_ti type I protein secretion system|protein secretion by the TOSS|protein secretion by the type I protein secretion system Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'. biological_process owl:Class
GO:0018014 biolink:NamedThing N-terminal peptidyl-methionine methylation The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine. got7fsn_ti RESID:AA0064 biological_process owl:Class
GO:0031215 biolink:NamedThing shell calcification The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell. got7fsn_ti biological_process owl:Class
GO:0047181 biolink:NamedThing tetrahydroxybenzophenone synthase activity Catalysis of the reaction: 3-hydroxybenzoyl-CoA + 3 malonyl-CoA = 3 CO2 + 2,3',4,6-tetrahydroxybenzophenone + 4 coenzyme A. got7fsn_ti malonyl-CoA:3-hydroxybenzoyl-CoA malonyltransferase activity EC:2.3.1.151|MetaCyc:2.3.1.151-RXN|RHEA:19305 molecular_function owl:Class
GO:0000949 biolink:NamedThing aromatic amino acid family catabolic process to alcohol via Ehrlich pathway The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. got7fsn_ti biological_process owl:Class
GO:0140359 biolink:NamedThing ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. got7fsn_ti ATP-binding cassette transporter|ABC-type efflux porter activity|ABC-type efflux permease activity|ATP binding cassette transporter|ABC-type uptake permease activity|ATP-binding cassette (ABC) transporter activity|ABC transporter|ABC-type transmembrane transporter activity https://github.com/geneontology/go-ontology/issues/21273|https://github.com/geneontology/go-ontology/issues/20529 pg 2019-06-25T19:08:14Z Wikipedia:ATP-binding_cassette_transporter|Reactome:R-HSA-5387389|TC:3.A.1|Reactome:R-HSA-5362459|Reactome:R-HSA-5683325|Reactome:R-HSA-266070|Reactome:R-HSA-5223313|Reactome:R-HSA-9661405 molecular_function owl:Class
GO:0008664 biolink:NamedThing 2'-5'-RNA ligase activity Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. got7fsn_ti 2'-5' RNA ligase activity molecular_function owl:Class
GO:0008452 biolink:NamedThing RNA ligase activity Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another. got7fsn_ti molecular_function owl:Class
GO:0102220 biolink:NamedThing hydrogenase activity (NAD+, ferredoxin) Catalysis of the reaction: 2 dihydrogen + NAD + 2 an oxidized ferredoxin = NADH + 3 H+ + 2 a reduced ferredoxin. got7fsn_ti MetaCyc:RXN-12215|EC:1.12.1.4|RHEA:30279 molecular_function owl:Class
GO:0009309 biolink:NamedThing amine biosynthetic process The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. got7fsn_ti amine biosynthesis|amine formation|amine anabolism|amine synthesis biological_process owl:Class
GO:0043204 biolink:NamedThing perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus. got7fsn_ti cell soma cytoplasm cellular_component owl:Class
GO:0008343 biolink:NamedThing adult feeding behavior Feeding behavior in a fully developed and mature organism. got7fsn_ti adult feeding behaviour See also the biological process term 'feeding behavior ; GO:0007631'. biological_process owl:Class
GO:0004914 biolink:NamedThing interleukin-5 receptor activity Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-5 receptor activity|IL-5R molecular_function owl:Class
GO:0018934 biolink:NamedThing nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment. got7fsn_ti nitrilotriacetate metabolism UM-BBD_pathwayID:nta biological_process owl:Class
GO:0102840 biolink:NamedThing 1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:3-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8301|EC:1.14.19.35 molecular_function owl:Class
GO:0060223 biolink:NamedThing retinal rod cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. got7fsn_ti biological_process owl:Class
GO:0022803 biolink:NamedThing passive transmembrane transporter activity Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged. got7fsn_ti uniporter activity z|facilitated diffusion|porters GO:0022814 Reactome:R-HSA-429767|Wikipedia:Facilitated_diffusion molecular_function owl:Class
GO:0051432 biolink:NamedThing BH1 domain binding Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists. got7fsn_ti molecular_function owl:Class
GO:0102713 biolink:NamedThing gibberellin A25 hydroxylase activity Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate(2-) + O2 <=> gibberellin A46 + succinate(2-) + carbon dioxide. got7fsn_ti MetaCyc:RXN-6543 molecular_function owl:Class
GO:0071535 biolink:NamedThing RING-like zinc finger domain binding Binding to a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain. got7fsn_ti mah 2010-01-08T03:10:14Z molecular_function owl:Class
GO:0050352 biolink:NamedThing trimethylamine-oxide aldolase activity Catalysis of the reaction: H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde. got7fsn_ti trimethylamine-N-oxide formaldehyde-lyase activity|trimethylamine-N-oxide formaldehyde-lyase (dimethylamine-forming)|trimethylamine N-oxide aldolase activity|trimethylamine N-oxide demethylase activity|trimethylamine N-oxide formaldehyde-lyase activity KEGG_REACTION:R02512|MetaCyc:TRIMETHYLAMINE-OXIDE-ALDOLASE-RXN|UM-BBD_reactionID:r1409|EC:4.1.2.32|RHEA:20217 molecular_function owl:Class
GO:1990690 biolink:NamedThing Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport. got7fsn_ti medial-Golgi cisterna-derived vesicle fusion with cis-Golgi cisterna membrane bhm 2015-03-12T09:47:03Z biological_process owl:Class
GO:0038185 biolink:NamedThing intracellular bile acid receptor signaling pathway A series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti nuclear bile acid receptor signaling pathway bf 2013-05-16T11:08:02Z biological_process owl:Class
GO:0015571 biolink:NamedThing N-acetylgalactosamine transmembrane transporter activity Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. got7fsn_ti N-acetylgalactosamine permease activity GO:0015590 molecular_function owl:Class
GO:0044534 biolink:NamedThing envenomation resulting in modulation of apoptotic process in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism. got7fsn_ti jl 2012-03-21T11:39:44Z biological_process owl:Class
GO:0040008 biolink:NamedThing regulation of growth Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development. got7fsn_ti biological_process owl:Class
GO:0103105 biolink:NamedThing 2-oxo-6-methylthiohexanoate aminotransferase activity Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + a standard alpha amino acid <=> dihomomethionine + a 2-oxo carboxylate. got7fsn_ti MetaCyc:RXNQT-4345 molecular_function owl:Class
GO:0140681 biolink:NamedThing histone H3-tri/dimethyl-lysine-36 demethylase activity Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone H3K36me3 demethylase activity|histone H3K36me2 demethylase activity https://github.com/geneontology/go-ontology/issues/21089 pg 2021-07-08T14:12:31Z RHEA:60236|MetaCyc: RXN-8660|EC:1.14.11.69 molecular_function owl:Class
GO:0033355 biolink:NamedThing ascorbate glutathione cycle A cyclic series of interconversions involving L-ascorbate and glutathione that scavenges hydrogen peroxide and reduces it to water, with concomitant oxidation of NADPH. got7fsn_ti hydrogen peroxide detoxification MetaCyc:PWY-2261 biological_process owl:Class
GO:0019852 biolink:NamedThing L-ascorbic acid metabolic process The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. got7fsn_ti vitamin C metabolism|vitamin C metabolic process|ascorbate metabolism|L-ascorbic acid metabolism|ascorbate metabolic process biological_process owl:Class
GO:0031708 biolink:NamedThing endothelin B receptor binding Binding to an endothelin B receptor. got7fsn_ti endothelin B receptor ligand molecular_function owl:Class
GO:0003977 biolink:NamedThing UDP-N-acetylglucosamine diphosphorylase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. got7fsn_ti UDP-GlcNAc pyrophosphorylase activity|N-acetylglucosamine-1-phosphate uridyltransferase activity|uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity|GlmU uridylyltransferase activity|UDP-acetylglucosamine pyrophosphorylase activity|UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity|acetylglucosamine 1-phosphate uridylyltransferase|UDP-N-acetylglucosamine pyrophosphorylase activity|UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity|uridine diphosphoacetylglucosamine pyrophosphorylase activity|uridine diphosphoacetylglucosamine phosphorylase activity MetaCyc:NAG1P-URIDYLTRANS-RXN|RHEA:13509|Reactome:R-HSA-446204|EC:2.7.7.23|KEGG_REACTION:R00416 molecular_function owl:Class
GO:0018818 biolink:NamedThing acetylene hydratase activity Catalysis of the reaction: acetaldehyde = acetylene + H(2)O. got7fsn_ti AH|AHy|acetaldehyde hydro-lyase activity MetaCyc:R141-RXN|RHEA:17885|KEGG_REACTION:R05380|UM-BBD_reactionID:r0591|EC:4.2.1.112 molecular_function owl:Class
GO:0075002 biolink:NamedThing adhesion of symbiont germination tube to host The attachment of a germination tube of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti adhesion of symbiont germination tube to host during symbiotic interaction Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0102617 biolink:NamedThing oryzalexin C synthase (oryzalexin B dependent) activity Catalysis of the reaction: oryzalexin B + NAD(P) <=> oryzalexin C + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-15465 molecular_function owl:Class
GO:0004092 biolink:NamedThing carnitine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA. got7fsn_ti carnitine-acetyl-CoA transferase activity|carnitine acetyl coenzyme A transferase activity|carnitine O-acetyltransferase II activity|carnitine acetylase activity|carnitine acetyltransferase activity|acetylcarnitine transferase activity|carnitine O-acetyltransferase I activity|acetyl-CoA:carnitine O-acetyltransferase activity|CATC|acetyl-CoA-carnitine O-acetyltransferase activity GO:0004094|GO:0004093 Reactome:R-HSA-390284|MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN|EC:2.3.1.7|Reactome:R-HSA-390291|RHEA:21136|KEGG_REACTION:R02396 molecular_function owl:Class
GO:0018153 biolink:NamedThing isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine. got7fsn_ti RESID:AA0124 biological_process owl:Class
GO:0061130 biolink:NamedThing pancreatic bud formation The morphogenetic process in which the foregut region specified to become the pancreas forms a bud. got7fsn_ti dph 2010-05-17T09:33:40Z biological_process owl:Class
GO:0061114 biolink:NamedThing branching involved in pancreas morphogenesis The process in which the branches of the pancreas are generated and organized. got7fsn_ti dph 2010-05-05T12:03:04Z biological_process owl:Class
GO:0030894 biolink:NamedThing replisome A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins. got7fsn_ti RC complex|replication-competent complex|DNA synthesome complex Wikipedia:Replisome cellular_component owl:Class
GO:0006537 biolink:NamedThing glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. got7fsn_ti glutamic acid biosynthetic process|glutamate biosynthetic process, using glutamate synthase (NADPH)|glutamate biosynthesis|glutamate synthesis|glutamic acid biosynthesis|glutamate anabolism|glutamate biosynthesis, using glutamate synthase (NADPH)|glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)|glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)|glutamate formation biological_process owl:Class
GO:0071090 biolink:NamedThing alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to fibronectin and tissue transglutaminase. got7fsn_ti ITGA2b-ITGB3-FN1-TGM2 complex mah 2009-11-06T04:46:24Z cellular_component owl:Class
GO:0052391 biolink:NamedThing induction by symbiont of defense-related host calcium ion flux The activation by an organism of a flux of calcium ions that occurs as part of the defense response of a host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti activation by symbiont of defense-related host calcium ion flux|upregulation by symbiont of defense-related host calcium ion flux|positive regulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction|up regulation by symbiont of defense-related host calcium ion flux|stimulation by symbiont of defense-related host calcium ion flux|positive regulation by symbiont of defense-related host calcium ion flux|activation by organism of host calcium ion flux|induction by organism of host Ca2+ flux|induction by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction|activation by organism of host Ca2+ flux|up-regulation by symbiont of defense-related host calcium ion flux|positive regulation by organism of defense-related host Ca2+ flux GO:0052389|GO:0052265|GO:0052065 biological_process owl:Class
GO:0034349 biolink:NamedThing glial cell apoptotic process Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system. got7fsn_ti apoptosis of glia|programmed cell death, glial cells|glia programmed cell death by apoptosis|glial cell apoptosis|programmed cell death of glia by apoptosis|glial cell programmed cell death by apoptosis|programmed cell death, glia|apoptosis of glial cells|glia apoptosis|programmed cell death of glial cells by apoptosis biological_process owl:Class
GO:0034798 biolink:NamedThing fosfomycin 2-L-cysteine ligase activity Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid. got7fsn_ti UM-BBD_reactionID:r1074 molecular_function owl:Class
GO:0102066 biolink:NamedThing alpha-patchoulene synthase activityy Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphoric acid + alpha-patchoulene. got7fsn_ti MetaCyc:RXN-10603 molecular_function owl:Class
GO:0004784 biolink:NamedThing superoxide dismutase activity Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. got7fsn_ti SOD-4|iron superoxide oxidoreductase|Mn, Fe superoxide dismutase|cytocuprein|SOD-3|iron superoxide dismutase activity|ferrisuperoxide dismutase activity|manganese superoxide oxidoreductase|SODS|superoxide dismutase I|Mn-SOD|Fe-SOD|hepatocuprein|SODF|cuprein|SOD-1|SOD-2|hemocuprein|Cu-Zn superoxide dismutase activity|zinc superoxide oxidoreductase|nickel superoxide dismutase activity|superoxide dismutase II|SOD|erythrocuprein|superoxide:superoxide oxidoreductase activity|nickel superoxide oxidoreductase|manganese superoxide dismutase activity|copper, zinc superoxide dismutase activity|Cu,Zn-SOD GO:0008383|GO:0004785|GO:0008382|GO:0016954 Reactome:R-HSA-3299691|Reactome:R-HSA-1222469|EC:1.15.1.1|MetaCyc:SUPEROX-DISMUT-RXN|Reactome:R-HSA-3299682|Reactome:R-HSA-1222462|Reactome:R-HSA-3299680|RHEA:20696|Reactome:R-HSA-3777112 molecular_function owl:Class
GO:0070923 biolink:NamedThing siRNA loading onto RISC involved in gene silencing by small RNA The process in which a single-stranded small RNA associates with the RNA-initiated silencing complex (RISC); occurs as part of a process of chromatin gene by small RNA. got7fsn_ti chromatin silencing by small RNA, siRNA loading onto RISC|siRNA loading onto RISC involved in chromatin silencing by small RNA https://github.com/geneontology/go-ontology/issues/22058 mah 2009-09-11T04:01:44Z biological_process owl:Class
GO:0005831 biolink:NamedThing steroid hormone aporeceptor complex A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand. got7fsn_ti cellular_component owl:Class
GO:0080034 biolink:NamedThing host response to induction by symbiont of tumor, nodule or growth in host Any process that results in a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the formation of an abnormal mass of cells in the host organism, induced by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:1990745 biolink:NamedThing EARP complex A quatrefoil tethering complex required for endocytic recycling. got7fsn_ti sp 2015-05-15T10:23:25Z cellular_component owl:Class
GO:0047905 biolink:NamedThing fructose-6-phosphate phosphoketolase activity Catalysis of the reaction: D-fructose 6-phosphate + phosphate = acetyl phosphate + D-erythrose 4-phosphate + H2O. got7fsn_ti D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)|D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity RHEA:12196|EC:4.1.2.22|MetaCyc:FRUCTOSE-6-PHOSPHATE-PHOSPHOKETOLASE-RXN molecular_function owl:Class
GO:0052796 biolink:NamedThing exo-alpha-(2->8)-sialidase activity Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates. got7fsn_ti exo-alpha-2,8-sialidase activity|exo-alpha-(2,8)-sialidase activity EC:3.2.1.18 molecular_function owl:Class
GO:0090465 biolink:NamedThing arginine homeostasis Any process involved in the maintenance of an internal steady state of arginine within an organism or cell. got7fsn_ti tb 2012-09-24T14:22:02Z biological_process owl:Class
GO:0009408 biolink:NamedThing response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. got7fsn_ti response to heat shock GO:0006951 biological_process owl:Class
GO:0072341 biolink:NamedThing modified amino acid binding Binding to a modified amino acid. got7fsn_ti amino acid derivative binding mah 2010-11-04T05:45:32Z molecular_function owl:Class
GO:0001079 biolink:NamedThing nitrogen catabolite regulation of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. got7fsn_ti regulation of transcription from RNA polymerase II promoter by nitrogen catabolites krc 2010-10-27T03:29:01Z biological_process owl:Class
GO:0043143 biolink:NamedThing regulation of translation by machinery localization Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location. got7fsn_ti establishment and maintenance of translational protein localization|translational machinery localization|regulation of translation by machinery localisation|establishment and maintenance of translational machinery localization|translational protein localization biological_process owl:Class
GO:0001919 biolink:NamedThing regulation of receptor recycling Any process that modulates the frequency, rate, or extent of receptor recycling. got7fsn_ti biological_process owl:Class
GO:0004369 biolink:NamedThing glycerol-3-phosphate oxidase activity Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2). got7fsn_ti L-alpha-glycerophosphate oxidase activity|glycerol-1-phosphate oxidase activity|alpha-glycerophosphate oxidase activity|L-alpha-glycerol-3-phosphate oxidase activity|glycerol phosphate oxidase activity|sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity RHEA:18369|EC:1.1.3.21|KEGG_REACTION:R00846|MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN molecular_function owl:Class
GO:0035316 biolink:NamedThing non-sensory hair organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis. got7fsn_ti trichome organization and biogenesis|trichome organisation|non-sensory hair organization and biogenesis See also the fly_anatomy.ontology term 'trichome ; FBbt:00004979'. biological_process owl:Class
GO:0051030 biolink:NamedThing snRNA transport The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0038169 biolink:NamedThing somatostatin receptor signaling pathway The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti SSTR signaling pathway|SST receptor signaling pathway In addition to somatostatin (SST), the somatostatin receptors (SSTRs) can also be activated by the agonist cortistatin (CST). For signal transduction specifically initiated by the ligand somatostatin, consider instead annotating to the child term 'somatostatin signaling pathway ; GO:0038170'. bf 2012-06-12T10:30:01Z biological_process owl:Class
GO:0001052 biolink:NamedThing plastid PEP RNA polymerase core enzyme binding Binding to a bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit. got7fsn_ti krc 2010-09-23T02:49:31Z molecular_function owl:Class
GO:0001000 biolink:NamedThing bacterial-type RNA polymerase core enzyme binding Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit. got7fsn_ti eubacterial-type RNA polymerase core enzyme binding Should omega be included here? krc 2010-08-17T04:59:00Z molecular_function owl:Class
GO:0047745 biolink:NamedThing chlorogenate hydrolase activity Catalysis of the reaction: chlorogenate + H(2)O = (-)-quinate + cis-caffeate + H(+). got7fsn_ti chlorogenic acid esterase activity|chlorogenase activity EC:3.1.1.42|MetaCyc:CHLOROGENATE-HYDROLASE-RXN|KEGG_REACTION:R02997|RHEA:20689 molecular_function owl:Class
GO:1901564 biolink:NamedThing organonitrogen compound metabolic process The chemical reactions and pathways involving organonitrogen compound. got7fsn_ti organonitrogen compound metabolism pr 2012-11-04T15:17:52Z biological_process owl:Class
GO:0090215 biolink:NamedThing regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. got7fsn_ti tb 2010-01-12T10:00:45Z biological_process owl:Class
GO:0016864 biolink:NamedThing intramolecular oxidoreductase activity, transposing S-S bonds Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears. got7fsn_ti intramolecular isomerase activity, transposing S-S bonds EC:5.3.4.- molecular_function owl:Class
GO:0039576 biolink:NamedThing suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1). got7fsn_ti suppression by virus of tyrosine phosphorylation of host STAT protein|suppression by virus of host janus kinase 1 activity|inhibition of host JAK activity by virus|negative regulation by virus of host JAK|viral inhibition of tyrosine phosphorylation of host STAT protein|negative regulation by virus of tyrosine phosphorylation of host STAT protein|suppression by virus of host JAK1 activity https://github.com/geneontology/go-ontology/issues/21963 bf GO:0039515 VZ:784 biological_process owl:Class
GO:0034997 biolink:NamedThing alphav-beta5 integrin-vitronectin complex A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin. got7fsn_ti ITGAV-ITGB5-VTN complex cellular_component owl:Class
GO:0051960 biolink:NamedThing regulation of nervous system development Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue. got7fsn_ti biological_process owl:Class
GO:1990747 biolink:NamedThing pancreatic trypsinogen secretion The regulated release of trypsinogen from the cells of the exocrine pancreas. got7fsn_ti pancreatic trypsinogen release sl 2015-05-15T17:41:25Z biological_process owl:Class
GO:0008686 biolink:NamedThing 3,4-dihydroxy-2-butanone-4-phosphate synthase activity Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+). got7fsn_ti EC:4.1.99.12|MetaCyc:DIOHBUTANONEPSYN-RXN|KEGG_REACTION:R07281|RHEA:18457 molecular_function owl:Class
GO:0102359 biolink:NamedThing daphnetin 4-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin <=> UDP + 4-O- beta -D-glucosyl-daphnetin + H+. got7fsn_ti MetaCyc:RXN-13450|EC:2.4.1.126 molecular_function owl:Class
GO:0047139 biolink:NamedThing glutathione-homocystine transhydrogenase activity Catalysis of the reaction: homocystine + 2 reduced glutathione = oxidized glutathione + 2 homocysteine. got7fsn_ti glutathione:homocystine oxidoreductase activity EC:1.8.4.1|MetaCyc:1.8.4.1-RXN|RHEA:11464 molecular_function owl:Class
GO:0047405 biolink:NamedThing pyrimidine-5'-nucleotide nucleosidase activity Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine. got7fsn_ti Pyr5N activity|pyrimidine nucleotide N-ribosidase activity|pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase activity MetaCyc:3.2.2.10-RXN|RHEA:13425|EC:3.2.2.10 molecular_function owl:Class
GO:0000492 biolink:NamedThing box C/D snoRNP assembly The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex. got7fsn_ti box C/D small nucleolar ribonucleoprotein complex assembly biological_process owl:Class
GO:0000491 biolink:NamedThing small nucleolar ribonucleoprotein complex assembly The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex. got7fsn_ti snoRNP assembly biological_process owl:Class
GO:0033522 biolink:NamedThing histone H2A ubiquitination The modification of histone H2A by addition of one or more ubiquitin groups. got7fsn_ti biological_process owl:Class
GO:0071501 biolink:NamedThing cellular response to sterol depletion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. got7fsn_ti cellular sterol depletion response mah 2009-12-18T02:54:14Z biological_process owl:Class
GO:0070698 biolink:NamedThing type I activin receptor binding Binding to a type I activin receptor. got7fsn_ti mah 2009-06-04T04:15:21Z molecular_function owl:Class
GO:0047562 biolink:NamedThing 3-hydroxyaspartate aldolase activity Catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate. got7fsn_ti erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase (glycine-forming)|erythro-3-hydroxy-Ls-aspartate glyoxylate-lyase activity|erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity|erythro-beta-hydroxyaspartate aldolase activity|erythro-beta-hydroxyaspartate glycine-lyase activity MetaCyc:3-HYDROXYASPARTATE-ALDOLASE-RXN|KEGG_REACTION:R00478|EC:4.1.3.14|RHEA:14377 molecular_function owl:Class
GO:0034741 biolink:NamedThing APC-tubulin-IQGAP1 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), alpha-tubulin, gamma-tubulin, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization. got7fsn_ti 60S APC complex Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0005655 biolink:NamedThing nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. got7fsn_ti nucleolar RNase P complex cellular_component owl:Class
GO:0043975 biolink:NamedThing histone H3-K36 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone. got7fsn_ti histone H3 acetylation at K36|histone H3K36 acetylation biological_process owl:Class
GO:0045998 biolink:NamedThing positive regulation of ecdysteroid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. got7fsn_ti stimulation of ecdysteroid biosynthetic process|positive regulation of ecdysteroid synthesis|up-regulation of ecdysteroid biosynthetic process|up regulation of ecdysteroid biosynthetic process|upregulation of ecdysteroid biosynthetic process|positive regulation of ecdysteroid anabolism|activation of ecdysteroid biosynthetic process|positive regulation of ecdysteroid formation|positive regulation of ecdysteroid biosynthesis biological_process owl:Class
GO:0086041 biolink:NamedThing voltage-gated potassium channel activity involved in SA node cell action potential depolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated potassium channel activity involved in sinus node cell action potential depolarization|voltage-gated potassium channel activity involved in sinoatrial node cell action potential depolarization|voltage-gated potassium channel activity involved in SAN cell action potential depolarization tb 2011-11-11T03:37:42Z molecular_function owl:Class
GO:1900351 biolink:NamedThing regulation of methanofuran biosynthetic process Any process that modulates the frequency, rate or extent of methanofuran biosynthetic process. got7fsn_ti regulation of methanofuran biosynthesis tt 2012-04-06T02:13:51Z biological_process owl:Class
GO:0042068 biolink:NamedThing regulation of pteridine metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine. got7fsn_ti regulation of pteridine metabolism biological_process owl:Class
GO:0102942 biolink:NamedThing 3,5-dimethoxyphenol O-methyltransferase activity Catalysis of the reaction: 3,5-dimethoxyphenol + S-adenosyl-L-methionine = H+ + 1,3,5-trimethoxybenzene + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-9022 molecular_function owl:Class
GO:0045004 biolink:NamedThing DNA replication proofreading Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity. got7fsn_ti biological_process owl:Class
GO:0044322 biolink:NamedThing endoplasmic reticulum quality control compartment A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins. got7fsn_ti ER-derived quality control compartment|ERQC|ER quality control compartment jl 2010-08-03T01:12:59Z cellular_component owl:Class
GO:0102105 biolink:NamedThing demethoxycurcumin synthase activity from feruloylacetyl-CoA Catalysis of the reaction: feruloylacetyl-CoA + 4-coumaryl-CoA + H2O = demethoxycurcumin + 2 coenzyme A + carbon dioxide. got7fsn_ti RHEA:35139|EC:2.3.1.219|MetaCyc:RXN-11225 molecular_function owl:Class
GO:0002566 biolink:NamedThing somatic diversification of immune receptors via somatic mutation The process in which immune receptor genes are diversified through somatic mutation. got7fsn_ti biological_process owl:Class
GO:0035613 biolink:NamedThing RNA stem-loop binding Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. got7fsn_ti RNA hairpin binding|RNA hairpin loop binding bf 2010-11-26T10:41:49Z molecular_function owl:Class
GO:0035685 biolink:NamedThing helper T cell diapedesis The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. got7fsn_ti helper T-cell diapedesis|T-helper cell diapedesis bf 2011-02-23T01:11:52Z biological_process owl:Class
GO:0047024 biolink:NamedThing 5alpha-androstane-3beta,17beta-diol dehydrogenase activity Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH. got7fsn_ti 3-beta-HSD activity|3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase activity|dehydrogenase, 3beta,20alpha-hydroxy steroid|3-beta(or 20-alpha)-hydroxysteroid dehydrogenase activity|3beta,20alpha-hydroxysteroid oxidoreductase activity|progesterone reductase activity|3beta(or 20alpha)-hydroxysteroid dehydrogenase activity MetaCyc:1.1.1.210-RXN|RHEA:16297|KEGG_REACTION:R04344|EC:1.1.1.210 molecular_function owl:Class
GO:0031049 biolink:NamedThing programmed DNA elimination The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate. got7fsn_ti biological_process owl:Class
GO:0006623 biolink:NamedThing protein targeting to vacuole The process of directing proteins towards the vacuole, usually using signals contained within the protein. got7fsn_ti vacuolar protein sorting|protein-vacuole targeting|protein vacuolar targeting|protein-vacuolar targeting biological_process owl:Class
GO:0031786 biolink:NamedThing type 1B melatonin receptor binding Binding to a type 1B melatonin receptor. got7fsn_ti type 1B melatonin receptor ligand molecular_function owl:Class
GO:0055029 biolink:NamedThing nuclear DNA-directed RNA polymerase complex A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity. got7fsn_ti cellular_component owl:Class
GO:0052832 biolink:NamedThing inositol monophosphate 3-phosphatase activity Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate. got7fsn_ti ai 2011-11-29T11:00:09Z RHEA:30739|Reactome:R-HSA-1855210|MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN|EC:3.1.3.25 molecular_function owl:Class
GO:0002416 biolink:NamedThing IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals. got7fsn_ti IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor|IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor biological_process owl:Class
GO:0002414 biolink:NamedThing immunoglobulin transcytosis in epithelial cells The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other. got7fsn_ti biological_process owl:Class
GO:0001010 biolink:NamedThing RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions. got7fsn_ti transcription factor activity, sequence-specific DNA-binding transcription factor recruiting|transcription factor activity, sequence-specific DNA binding transcription factor recruiting|sequence-specific DNA binding transcription factor recruiting transcription factor activity krc 2010-08-18T06:46:33Z molecular_function owl:Class
GO:0106365 biolink:NamedThing beta-carotene isomerase activity Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene. got7fsn_ti hjd 2021-02-16T15:32:24Z EC:5.2.1.14|RHEA:34455 molecular_function owl:Class
GO:0009305 biolink:NamedThing protein biotinylation The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid. got7fsn_ti protein amino acid biotinylation biological_process owl:Class
GO:0050087 biolink:NamedThing mannitol dehydrogenase (cytochrome) activity Catalysis of the reaction: 2 [Fe(III)cytochrome c] + D-mannitol = 2 [Fe(II)cytochrome c] + D-fructose + 2 H+. got7fsn_ti D-mannitol:ferricytochrome-c 2-oxidoreductase activity|polyol dehydrogenase activity MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN|RHEA:17597|EC:1.1.2.2 molecular_function owl:Class
GO:0016898 biolink:NamedThing oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule. got7fsn_ti EC:1.1.2.- molecular_function owl:Class
GO:0018454 biolink:NamedThing acetoacetyl-CoA reductase activity Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+. got7fsn_ti acetoacetyl coenzyme A reductase activity|D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity|(R)-3-hydroxyacyl-CoA dehydrogenase activity|short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity|NADP-linked acetoacetyl CoA reductase activity|(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity|hydroxyacyl coenzyme-A dehydrogenase activity|D-3-hydroxyacyl-CoA reductase activity|beta-ketoacyl-CoA reductase|NADPH:acetoacetyl-CoA reductase activity RHEA:22256|UM-BBD_reactionID:r0202|MetaCyc:RXN-7698|EC:1.1.1.36 molecular_function owl:Class
GO:0046778 biolink:NamedThing modification by virus of host mRNA processing Any viral process that interferes with the processing of mRNA in the host cell. got7fsn_ti viral perturbation of host mRNA processing biological_process owl:Class
GO:0050684 biolink:NamedThing regulation of mRNA processing Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide. got7fsn_ti biological_process owl:Class
GO:0030756 biolink:NamedThing isoorientin 3'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin. got7fsn_ti isoorientin 3'-methyltransferase activity|S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity EC:2.1.1.78|KEGG_REACTION:R03731|RHEA:24096|MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0005034 biolink:NamedThing osmosensor activity Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. got7fsn_ti molecular_function owl:Class
GO:0048100 biolink:NamedThing wing disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing. got7fsn_ti biological_process owl:Class
GO:0032783 biolink:NamedThing super elongation complex A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae. got7fsn_ti ELL-EAF complex|ELL-EAF-EBP complex https://github.com/geneontology/go-ontology/issues/17203 cellular_component owl:Class
GO:0021507 biolink:NamedThing posterior neuropore closure The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete. got7fsn_ti biological_process owl:Class
GO:0030244 biolink:NamedThing cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. got7fsn_ti cellulose biosynthesis|cellulose anabolism|cellulose synthesis|cellulose formation GO:0016178 MetaCyc:PWY-1001 biological_process owl:Class
GO:0061073 biolink:NamedThing ciliary body morphogenesis The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes. got7fsn_ti dph 2010-03-16T10:55:19Z biological_process owl:Class
GO:0106092 biolink:NamedThing glial cell projection elongation involved in axon ensheathment The extension of a glial cell process or projection to wrap around an axon. got7fsn_ti hjd 2018-01-26T19:43:00Z biological_process owl:Class
GO:0106091 biolink:NamedThing glial cell projection elongation The process of creating an elongation or projection from a glial cell. got7fsn_ti hjd 2018-01-26T19:40:19Z biological_process owl:Class
GO:0047428 biolink:NamedThing arylacetonitrilase activity Catalysis of the reaction: 2 H2O + 4-chlorophenylacetonitrile = 4-chlorophenylacetate + NH3. got7fsn_ti arylacetonitrile aminohydrolase activity MetaCyc:3.5.5.5-RXN|RHEA:20657|EC:3.5.5.5 molecular_function owl:Class
GO:0102082 biolink:NamedThing demethylrebeccamycin--D-glucose O-methyltransferase activity Catalysis of the reaction: 4'-demethylrebeccamycin + S-adenosyl-L-methionine <=> H+ + rebeccamycin + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.164|MetaCyc:RXN-10847|RHEA:27353 molecular_function owl:Class
GO:0072432 biolink:NamedThing response to G1 DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of G1/S transition DNA damage checkpoint signaling. got7fsn_ti response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint|response to mitotic cell cycle G1/S transition DNA damage checkpoint signaling|mitotic cell cycle G1/S transition DNA damage checkpoint effector process mah 2010-12-08T04:38:04Z biological_process owl:Class
GO:0007489 biolink:NamedThing maintenance of imaginal histoblast diploidy The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells. got7fsn_ti biological_process owl:Class
GO:0044641 biolink:NamedThing envenomation resulting in positive regulation of complement activation, lectin pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism. got7fsn_ti jl 2012-07-11T11:50:23Z biological_process owl:Class
GO:0006615 biolink:NamedThing SRP-dependent cotranslational protein targeting to membrane, docking The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting. got7fsn_ti SRP-dependent cotranslational membrane targeting, docking|SRP-dependent cotranslational protein-membrane targeting, docking|protein docking during SRP-dependent cotranslational protein targeting to membrane biological_process owl:Class
GO:0022615 biolink:NamedThing protein to membrane docking The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere. got7fsn_ti protein-membrane docking biological_process owl:Class
GO:0071282 biolink:NamedThing cellular response to iron(II) ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. got7fsn_ti cellular response to iron(II) mah 2009-12-10T03:57:49Z biological_process owl:Class
GO:0010040 biolink:NamedThing response to iron(II) ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus. got7fsn_ti response to iron(II) biological_process owl:Class
GO:0030502 biolink:NamedThing negative regulation of bone mineralization Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization. got7fsn_ti inhibition of bone mineralization|down regulation of bone mineralization|downregulation of bone mineralization|down-regulation of bone mineralization biological_process owl:Class
GO:0030279 biolink:NamedThing negative regulation of ossification Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance. got7fsn_ti downregulation of ossification|negative regulation of bone formation|down-regulation of ossification|negative regulation of bone biosynthesis|down regulation of ossification|inhibition of ossification biological_process owl:Class
GO:0004765 biolink:NamedThing shikimate kinase activity Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+). got7fsn_ti shikimate kinase (phosphorylating)|ATP:shikimate 3-phosphotransferase activity|shikimate kinase II KEGG_REACTION:R02412|MetaCyc:SHIKIMATE-KINASE-RXN|RHEA:13121|EC:2.7.1.71 molecular_function owl:Class
GO:0000824 biolink:NamedThing inositol tetrakisphosphate 3-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. got7fsn_ti EC:2.7.1.151|IpmK|inositol 1,4,5,6-tetrakisphosphate 3-kinase activity|inositol polyphosphate multikinase activity|1D-myo-inositol-tetrakisphosphate 3-kinase activity RHEA:11856|Reactome:R-HSA-1855185 molecular_function owl:Class
GO:0051765 biolink:NamedThing inositol tetrakisphosphate kinase activity Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP. got7fsn_ti molecular_function owl:Class
GO:0004829 biolink:NamedThing threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). got7fsn_ti threonyl-transfer ribonucleic acid synthetase activity|L-threonine:tRNAThr ligase (AMP-forming)|threonyl ribonucleic synthetase activity|threonine-transfer ribonucleate synthetase activity|TRS|threonine translase activity|threonyl-tRNA synthetase activity|threonyl-transfer ribonucleate synthetase activity|threonyl-transfer RNA synthetase activity EC:6.1.1.3|RHEA:24624|Reactome:R-HSA-380002|MetaCyc:THREONINE--TRNA-LIGASE-RXN|Reactome:R-HSA-380201 molecular_function owl:Class
GO:0046484 biolink:NamedThing oxazole or thiazole metabolic process The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position. got7fsn_ti oxazole or thiazole metabolism biological_process owl:Class
GO:0044077 biolink:NamedThing modulation by symbiont of host receptor-mediated endocytosis The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism. got7fsn_ti modulation of host receptor-mediated endocytosis by symbiont|regulation by symbiont of host receptor-mediated endocytosis biological_process owl:Class
GO:0044587 biolink:NamedThing cellopentaose binding Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose. got7fsn_ti jl 2012-04-24T04:57:01Z molecular_function owl:Class
GO:0032163 biolink:NamedThing hyphal septin band A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously. got7fsn_ti cellular_component owl:Class
GO:0071153 biolink:NamedThing G-protein alpha(o)-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(o) subunit of a heterotrimeric G protein. got7fsn_ti Ric-8A G(o) alpha-2 subunit complex|Ric-8A G(o) alpha-1 subunit complex mah 2009-11-16T04:55:00Z cellular_component owl:Class
GO:0033107 biolink:NamedThing Cvt vesicle A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p). got7fsn_ti cytoplasm-to-vacuole targeting vesicle|cytoplasm to vacuole targeting vesicle cellular_component owl:Class
GO:0004603 biolink:NamedThing phenylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine. got7fsn_ti S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity|noradrenaline N-methyltransferase activity|norepinephrine methyltransferase activity|norepinephrine N-methyltransferase activity|phenethanolamine methyltransferase activity|noradrenalin N-methyltransferase activity|phenethanolamine N-methyltransferase activity RHEA:12176|MetaCyc:2.1.1.28-RXN|EC:2.1.1.28|Reactome:R-HSA-209903 molecular_function owl:Class
GO:0047289 biolink:NamedThing galactosyldiacylglycerol alpha-2,3-sialyltransferase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + CMP-N-acetyl-beta-neuraminate = 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-glycerol + CMP + H(+). got7fsn_ti CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase activity RHEA:11664|KEGG_REACTION:R03468|MetaCyc:2.4.99.5-RXN|EC:2.4.99.5 molecular_function owl:Class
GO:0009739 biolink:NamedThing response to gibberellin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus. got7fsn_ti response to gibberellin stimulus|response to gibberellic acid stimulus biological_process owl:Class
GO:0150094 biolink:NamedThing amyloid-beta clearance by cellular catabolic process The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by intracellular degradation. got7fsn_ti amyloid-beta clearance by phagocytosis bc 2018-08-16T14:38:09Z biological_process owl:Class
GO:1990583 biolink:NamedThing phospholipase D activator activity Increases the activity of the enzyme phospholipase D. got7fsn_ti sl 2014-12-10T21:04:46Z molecular_function owl:Class
GO:0033917 biolink:NamedThing exo-poly-alpha-galacturonosidase activity Catalysis of the hydrolysis of pectic acid from the non-reducing end, releasing digalacturonate. got7fsn_ti exopolygalacturanosidase activity|exopolygalacturonosidase activity EC:3.2.1.82|RHEA:56232|MetaCyc:3.2.1.82-RXN molecular_function owl:Class
GO:0031584 biolink:NamedThing activation of phospholipase D activity Any process that initiates the activity of inactive phospholipase D. got7fsn_ti biological_process owl:Class
GO:0010518 biolink:NamedThing positive regulation of phospholipase activity Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid. got7fsn_ti biological_process owl:Class
GO:0072027 biolink:NamedThing connecting tubule development The process whose specific outcome is the progression of the connecting tubule over time, from its formation to the mature structure. The connecting tubule is a tubular segment of the nephron; it connects the distal convoluted tubule to the collecting duct. got7fsn_ti connecting duct development mah 2010-01-25T02:42:05Z biological_process owl:Class
GO:0008448 biolink:NamedThing N-acetylglucosamine-6-phosphate deacetylase activity Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate. got7fsn_ti acetylglucosamine phosphate deacetylase activity|N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity|2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity|acetylaminodeoxyglucosephosphate acetylhydrolase activity EC:3.5.1.25|Reactome:R-HSA-6803789|MetaCyc:NAG6PDEACET-RXN|RHEA:22936 molecular_function owl:Class
GO:0022033 biolink:NamedThing telencephalon microglial cell migration The orderly movement of microglial cells through the telencephalon. got7fsn_ti biological_process owl:Class
GO:0002033 biolink:NamedThing angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure The process that increases the diameter of a blood vessel via the renin-angiotensin system. got7fsn_ti vasodilation by angiotensin involved in regulation of systemic arterial blood pressure biological_process owl:Class
GO:0005109 biolink:NamedThing frizzled binding Binding to a frizzled (fz) receptor. got7fsn_ti fz2 binding|frizzled-2 ligand|fz ligand|fz2 ligand|frizzled ligand|frizzled-2 binding|fz binding GO:0005110 molecular_function owl:Class
GO:0047101 biolink:NamedThing 2-oxoisovalerate dehydrogenase (acylating) activity Catalysis of the reaction: NAD+ + CoA + 2-keto-isovalerate = NADH + CO2 + isobutyryl-CoA. got7fsn_ti 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating)|2-oxoisovalerate dehydrogenase activity EC:1.2.1.25|MetaCyc:1.2.1.25-RXN|RHEA:13997 molecular_function owl:Class
GO:0034076 biolink:NamedThing cucurbitadienol synthase activity Catalysis of the reaction: oxidosqualene = cucurbitadienol. got7fsn_ti molecular_function owl:Class
GO:0072270 biolink:NamedThing metanephric short nephron development The process whose specific outcome is the progression of a short nephron in the metanephros over time, from its formation to the mature structure. Short nephrons are associated with mid-cortical and superficial glomeruli, are situated entirely in the outer medulla, and have no thin ascending limb. got7fsn_ti mah 2010-03-30T03:15:18Z biological_process owl:Class
GO:0033755 biolink:NamedThing sulfur oxygenase/reductase activity Catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+. got7fsn_ti SOR|sulfur oxygenase activity|sulphur oxygenase/reductase activity|sulfur:oxygen oxidoreductase (hydrogen-sulfide- and sulfite-forming) activity EC:1.13.11.55|RHEA:13957|MetaCyc:1.13.11.55-RXN molecular_function owl:Class
GO:0106185 biolink:NamedThing histone H3-K37 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 37 of the histone. got7fsn_ti histone H3 K37 methylation|histone H3K37me|histone lysine H3 K37 methylation hjd 2019-04-24T14:36:23Z biological_process owl:Class
GO:0075111 biolink:NamedThing suppression by symbiont of host receptor-mediated signal transduction Any process in which the symbiont stops, prevents, or reduces the frequency, rate or extent of receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host receptor-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont receptor-mediated signal transduction ; GO:0075080". biological_process owl:Class
GO:0019124 biolink:NamedThing peptidyl-isoleucine racemization The racemization of peptidyl-isoleucine. got7fsn_ti GO:0018088|GO:0018370 RESID:AA0192 biological_process owl:Class
GO:0071154 biolink:NamedThing G-protein alpha(i)1-synembrin complex A protein complex formed by the association of the guanine nucleotide exchange factor synembrin with the alpha(i)1 subunit of a heterotrimeric G protein. got7fsn_ti Ric-8A G(i) alpha-2 subunit complex|Ric-8A G(i) alpha-1 subunit complex mah 2009-11-16T04:57:46Z cellular_component owl:Class
GO:0021721 biolink:NamedThing superior olivary nucleus structural organization The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. got7fsn_ti superior olivary nucleus structural organisation biological_process owl:Class
GO:0047476 biolink:NamedThing 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate-CoA ligase activity Catalysis of the reaction: CoA + 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate + ATP = 3-alpha,7-alpha-dihydroxy-5-beta-cholestanoyl-CoA + diphosphate + AMP. got7fsn_ti 3alpha,7alpha-dihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)|3alpha,7alpha-dihydroxy-5beta-cholestanoyl coenzyme A synthetase activity|DHCA-CoA ligase activity|3alpha,7alpha-dihydroxy-5beta-cholestanate-CoA ligase activity RHEA:21776|MetaCyc:6.2.1.28-RXN|EC:6.2.1.28 molecular_function owl:Class
GO:1990153 biolink:NamedThing maintenance of protein localization to heterochromatin A process in which a protein is maintained in a location in telomeric heterochromatin. got7fsn_ti maintenance of protein location in heterochromatin|maintenance of protein localisation to heterochromatin mah 2013-07-31T15:11:37Z biological_process owl:Class
GO:1902509 biolink:NamedThing methionine-importing complex A protein complex which is capable of methionine-importing activity. got7fsn_ti methionine importer complex|methionine importing complex pr 2013-11-15T10:42:41Z cellular_component owl:Class
GO:0001829 biolink:NamedThing trophectodermal cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell. got7fsn_ti trophectoderm cell differentiation See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. biological_process owl:Class
GO:0004664 biolink:NamedThing prephenate dehydratase activity Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. got7fsn_ti prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)|prephenate hydro-lyase (decarboxylating) EC:4.2.1.51|MetaCyc:PREPHENATEDEHYDRAT-RXN|RHEA:21648 molecular_function owl:Class
GO:0042587 biolink:NamedThing glycogen granule Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface. got7fsn_ti glycogen particle NIF_Subcellular:sao1081228141 cellular_component owl:Class
GO:0070225 biolink:NamedThing sulfide dehydrogenase activity Catalysis of the reaction: hydrogen sulfide + oxidized cytochrome c = S + reduced cytochrome c. got7fsn_ti sulphide dehydrogenase activity|flavocytochrome c sulfide dehydrogenase activity EC:1.8.2.3|RHEA:30223|MetaCyc:RXN-8156 molecular_function owl:Class
GO:0031973 biolink:NamedThing chromoplast intermembrane space The region between the inner and outer lipid bilayers of a chromoplast envelope. got7fsn_ti chromoplast envelope lumen cellular_component owl:Class
GO:0043833 biolink:NamedThing methylamine-specific methylcobalamin:coenzyme M methyltransferase activity Catalysis of the reaction: a methylated methylamine corrinoid protein + coenzyme M = a methylamine corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M. got7fsn_ti monomethylamine-specific methylcobalamin:coenzyme M methyltransferase activity|methylamine-specific methylcobalamin:CoM methyltransferase activity|methylcobamide:CoM methyltransferase activity|methylcobamide:coenzyme M methyltransferase activity|methylcobamide:CoM methyltransferase II isozyme A This function is the second step in the pathway of methanogenesis from monomethylamine, dimethylamine and trimethylamine. MetaCyc:RXN-8099|EC:2.1.1.247|MetaCyc:RXN-8103|MetaCyc:RXN-8101 molecular_function owl:Class
GO:0034799 biolink:NamedThing dihydride TNP tautomerase activity Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form). got7fsn_ti UM-BBD_reactionID:r1070 molecular_function owl:Class
GO:0008953 biolink:NamedThing penicillin amidase activity Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate. got7fsn_ti alpha-acylamino-beta-lactam acylhydrolase activity|novozym 217|penicillin amidohydrolase activity|benzylpenicillin acylase activity|penicillin acylase activity|semacylase activity|palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity|ampicillin acylase activity EC:3.5.1.11|RHEA:18693|MetaCyc:PENICILLIN-AMIDASE-RXN molecular_function owl:Class
GO:0008499 biolink:NamedThing UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. got7fsn_ti beta3Gal-Ts activity|UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|beta-1,3-GalTase activity|UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity Reactome:R-HSA-914010|Reactome:R-HSA-9603989 molecular_function owl:Class
GO:0035902 biolink:NamedThing response to immobilization stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile. got7fsn_ti response to restraint stress|response to immobilisation stress bf 2011-06-22T09:45:50Z biological_process owl:Class
GO:0007004 biolink:NamedThing telomere maintenance via telomerase The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase. got7fsn_ti telomerase-dependent telomere maintenance biological_process owl:Class
GO:0010833 biolink:NamedThing telomere maintenance via telomere lengthening Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA. got7fsn_ti biological_process owl:Class
GO:0102776 biolink:NamedThing UDP-D-glucose:pelargonidin-3-O-beta-D-glucoside 5-O-glucosyltransferase activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + UDP-alpha-D-glucose <=> anthocyanidin 3,5-di-O-beta-D-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-7828 molecular_function owl:Class
GO:0014057 biolink:NamedThing positive regulation of acetylcholine secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine. got7fsn_ti upregulation of acetylcholine secretion|up regulation of acetylcholine secretion|up-regulation of acetylcholine secretion|activation of acetylcholine secretion|stimulation of acetylcholine secretion biological_process owl:Class
GO:0033254 biolink:NamedThing vacuolar transporter chaperone complex A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p. got7fsn_ti VTC complex cellular_component owl:Class
GO:0010217 biolink:NamedThing cellular aluminum ion homeostasis Any process involved in the maintenance of an internal steady state of aluminum ions at the level of a cell. got7fsn_ti cellular aluminium ion homeostasis biological_process owl:Class
GO:0047711 biolink:NamedThing blasticidin-S deaminase activity Catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3. got7fsn_ti blasticidin-S aminohydrolase activity RHEA:10148|EC:3.5.4.23|MetaCyc:BLASTICIDIN-S-DEAMINASE-RXN molecular_function owl:Class
GO:0006799 biolink:NamedThing polyphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. got7fsn_ti polyphosphate biosynthesis|polyphosphate synthesis|polyphosphate formation|polyphosphate anabolism biological_process owl:Class
GO:0034438 biolink:NamedThing lipoprotein amino acid oxidation The modification of a lipoprotein by oxidation of one or more amino acids in the protein. got7fsn_ti biological_process owl:Class
GO:0009164 biolink:NamedThing nucleoside catabolic process The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). got7fsn_ti nucleoside breakdown|nucleoside degradation|nucleoside catabolism biological_process owl:Class
GO:1900585 biolink:NamedThing arugosin metabolic process The chemical reactions and pathways involving arugosin. got7fsn_ti arugosin metabolism di 2012-05-15T06:48:15Z biological_process owl:Class
GO:1900795 biolink:NamedThing terrequinone A catabolic process The chemical reactions and pathways resulting in the breakdown of terrequinone A. got7fsn_ti terrequinone A degradation|terrequinone A catabolism|terrequinone A breakdown di 2012-06-04T09:45:41Z biological_process owl:Class
GO:0071079 biolink:NamedThing alpha2-beta1 integrin-chondroadherin complex A protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin. got7fsn_ti ITGA2-ITGB1-CHAD complex mah 2009-11-06T04:42:55Z cellular_component owl:Class
GO:0010470 biolink:NamedThing regulation of gastrulation Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. got7fsn_ti biological_process owl:Class
GO:0070783 biolink:NamedThing growth of unicellular organism as a thread of attached cells A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions. got7fsn_ti mah 2009-07-07T02:21:14Z biological_process owl:Class
GO:0002003 biolink:NamedThing angiotensin maturation The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood. got7fsn_ti angiotensin catabolic process in blood GO:0002005 biological_process owl:Class
GO:0010273 biolink:NamedThing detoxification of copper ion Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion. got7fsn_ti biological_process owl:Class
GO:0097709 biolink:NamedThing connective tissue replacement The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared. got7fsn_ti pr 2016-05-17T10:49:10Z biological_process owl:Class
GO:0120301 biolink:NamedThing histone lactyltransferase activity Catalysis of the reaction: (L-lysyl-[histone] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[histone]. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20685 krc 2021-01-19T03:38:56Z molecular_function owl:Class
GO:0120300 biolink:NamedThing peptide lactyltransferase activity Catalysis of the reaction: (L-lysyl-[protein] + lactoyl-CoA = CoA + H(+) + N(6)-lactoyl-L-lysyl-[protein]. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20685 krc 2021-01-19T03:35:54Z RHEA:61996 molecular_function owl:Class
GO:0036317 biolink:NamedThing tyrosyl-RNA phosphodiesterase activity Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. got7fsn_ti VPg unlinkase activity|unlinkase activity|uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity|Y-pUpN PDE activity bf 2012-08-30T11:08:04Z molecular_function owl:Class
GO:0070713 biolink:NamedThing RNA guanosine-cytidine insertion The modification of an RNA molecule by insertion of an guanosine-cytidine dinucleotide. got7fsn_ti RNA GC insertion mah 2009-06-08T05:31:43Z biological_process owl:Class
GO:0047094 biolink:NamedThing 3-hydroxyphenylacetate 6-hydroxylase activity Catalysis of the reaction: O2 + NAD(P)H + 3-hydroxyphenylacetate = H2O + NAD(P)+ + homogentisate. got7fsn_ti 3-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (6-hydroxylating)|3-hydroxyphenylacetate 6-monooxygenase activity MetaCyc:1.14.13.63-RXN|EC:1.14.13.63 molecular_function owl:Class
GO:0042975 biolink:NamedThing peroxisome proliferator activated receptor binding Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma. got7fsn_ti PPAR binding molecular_function owl:Class
GO:0008961 biolink:NamedThing phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein. got7fsn_ti EC:2.5.1.145|RHEA:56712 molecular_function owl:Class
GO:1900352 biolink:NamedThing negative regulation of methanofuran biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of methanofuran biosynthetic process. got7fsn_ti negative regulation of methanofuran biosynthesis|down regulation of methanofuran biosynthesis|down regulation of methanofuran biosynthetic process|downregulation of methanofuran biosynthetic process|inhibition of methanofuran biosynthesis|down-regulation of methanofuran biosynthetic process|inhibition of methanofuran biosynthetic process|down-regulation of methanofuran biosynthesis|downregulation of methanofuran biosynthesis tt 2012-04-06T02:14:00Z biological_process owl:Class
GO:0098808 biolink:NamedThing mRNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an mRNA molecule. got7fsn_ti molecular_function owl:Class
GO:0047412 biolink:NamedThing N-(long-chain-acyl)ethanolamine deacylase activity Catalysis of the reaction: H2O + N-(long-chain-acyl)ethanolamine = ethanolamine + a fatty acid. got7fsn_ti acylethanolamine amidase activity|N-(long-chain-acyl)ethanolamine amidohydrolase activity|N-acylethanolamine amidohydrolase activity MetaCyc:3.5.1.60-RXN|EC:3.5.1.60|RHEA:17505 molecular_function owl:Class
GO:0047887 biolink:NamedThing farnesyl diphosphate kinase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + ATP = 2-trans,6-trans-farnesyl triphosphate + ADP. got7fsn_ti ATP:farnesyl-diphosphate phosphotransferase activity|farnesyl-diphosphate kinase activity|farnesyl pyrophosphate kinase activity EC:2.7.4.18|MetaCyc:FARNESYL-DIPHOSPHATE-KINASE-RXN|RHEA:21544|KEGG_REACTION:R02303 molecular_function owl:Class
GO:0080101 biolink:NamedThing phosphatidyl-N-dimethylethanolamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine. got7fsn_ti dhl 2009-04-23T04:02:41Z MetaCyc:RXN4FS-2|KEGG_REACTION:R01320|RHEA:32739|EC:2.1.1.71 molecular_function owl:Class
GO:0009979 biolink:NamedThing 16:0 monogalactosyldiacylglycerol desaturase activity Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule. got7fsn_ti molecular_function owl:Class
GO:0061321 biolink:NamedThing garland nephrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. got7fsn_ti garland cell differentiation dph 2010-09-24T12:28:16Z GO:0007514 biological_process owl:Class
GO:0038201 biolink:NamedThing TOR complex A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. got7fsn_ti target of rapamycin complex|TOR signaling complex|mTOR complex bf 2013-12-09T14:38:09Z cellular_component owl:Class
GO:0034458 biolink:NamedThing 3'-5' RNA helicase activity Unwinding of an RNA helix in the 3' to 5' direction, driven by ATP hydrolysis. got7fsn_ti 3' to 5' RNA helicase activity|ATP-dependent 3'-5' RNA helicase activity|ATP-dependent 3' to 5' RNA helicase activity https://github.com/geneontology/go-ontology/issues/21612 GO:0034459 molecular_function owl:Class
GO:0007352 biolink:NamedThing zygotic specification of dorsal/ventral axis The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote. got7fsn_ti zygotic determination of dorsal-ventral axis|zygotic determination of dorsal/ventral axis|zygotic determination of dorsoventral axis biological_process owl:Class
GO:0055047 biolink:NamedThing generative cell mitosis The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells. got7fsn_ti biological_process owl:Class
GO:1990778 biolink:NamedThing protein localization to cell periphery A process in which a protein is transported to, or maintained in, the cell periphery. got7fsn_ti 2015-06-18T22:37:39Z biological_process owl:Class
GO:0044229 biolink:NamedThing host cell periplasmic space The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi). got7fsn_ti jl 2009-12-03T01:52:31Z cellular_component owl:Class
GO:0047204 biolink:NamedThing chlorogenate-glucarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: D-glucarate + chlorogenate = (-)-quinate + 2-O-caffeoylglucarate. got7fsn_ti chlorogenate:glucarate O-(hydroxycinnamoyl)transferase activity|chlorogenic acid:glucaric acid O-caffeoyltransferase activity|chlorogenate:glucarate caffeoyltransferase activity KEGG_REACTION:R02998|RHEA:23204|EC:2.3.1.98|MetaCyc:2.3.1.98-RXN molecular_function owl:Class
GO:0046922 biolink:NamedThing peptide-O-fucosyltransferase activity Catalysis of the transfer of an alpha-L-fucosyl residue from GDP- beta-L-fucose to the serine hydroxy group of a protein acceptor. got7fsn_ti GDP-fucose protein O-fucosyltransferase activity|GDP-L-fucose:polypeptide fucosyltransferase activity|GDP-beta-L-fucose:polypeptide O-alpha-L-fucosyltransferase activity|GDP-fucose:polypeptide fucosyltransferase activity MetaCyc:2.4.1.221-RXN|Reactome:R-HSA-5173192|EC:2.4.1.221|Reactome:R-HSA-1912349 molecular_function owl:Class
GO:0003964 biolink:NamedThing RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. got7fsn_ti deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity|RNA-directed DNA polymerase, transposon encoded|RNA-instructed DNA polymerase activity|RNA revertase activity|RNA-directed DNA polymerase, group II intron encoded|DNA nucleotidyltransferase (RNA-directed) activity|RT|reverse transcriptase activity|RNA-dependent deoxyribonucleate nucleotidyltransferase activity|revertase activity|RNA-dependent DNA polymerase activity MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN|EC:2.7.7.49|Reactome:R-HSA-164520|Reactome:R-HSA-164504 molecular_function owl:Class
GO:0031041 biolink:NamedThing O-glycan processing, core 5 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc. got7fsn_ti biological_process owl:Class
GO:0046697 biolink:NamedThing decidualization The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. got7fsn_ti decidual cell reaction Wikipedia:Decidualization biological_process owl:Class
GO:0097437 biolink:NamedThing maintenance of dormancy The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated. got7fsn_ti pr 2012-12-05T15:00:24Z biological_process owl:Class
GO:0035945 biolink:NamedThing mitochondrial ncRNA surveillance The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion. got7fsn_ti mitochondrial non-coding RNA surveillance|mitochondrial aberrant ncRNA catabolic process|mitochondrial ncRNA quality control bf 2011-07-28T10:34:59Z biological_process owl:Class
GO:0016784 biolink:NamedThing 3-mercaptopyruvate sulfurtransferase activity Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate. got7fsn_ti beta-mercaptopyruvate sulfurtransferase activity|3-mercaptopyruvate sulphurtransferase activity|mercaptopyruvate sulfurtransferase activity|3-mercaptopyruvate:cyanide sulfurtransferase activity Reactome:R-HSA-9013471|EC:2.8.1.2|Reactome:R-HSA-9013533|RHEA:21740|Reactome:R-HSA-9012721|Reactome:R-HSA-9034756|MetaCyc:MERCAPYSTRANS-RXN molecular_function owl:Class
GO:0033923 biolink:NamedThing glucan 1,6-alpha-isomaltosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in polysaccharides, to remove successive isomaltose units from the non-reducing ends of the chains. got7fsn_ti isomaltodextranase activity|exo-isomaltohydrolase activity|isomalto-dextranase activity|G2-dextranase activity|1,6-alpha-D-glucan isomaltohydrolase activity EC:3.2.1.94|MetaCyc:3.2.1.94-RXN molecular_function owl:Class
GO:0060360 biolink:NamedThing negative regulation of leucine import in response to ammonium ion Any process that decreases the rate, frequency or extent of leucine import as a result of an ammonium ion stimulus. Leucine import is the directed movement of leucine into a cell or organelle. got7fsn_ti negative regulation of leucine uptake in response to ammonium ion biological_process owl:Class
GO:0060358 biolink:NamedThing negative regulation of leucine import Any process that decreases the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle. got7fsn_ti biological_process owl:Class
GO:0102473 biolink:NamedThing eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity Catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+. got7fsn_ti MetaCyc:RXN-14079 molecular_function owl:Class
GO:0004652 biolink:NamedThing polynucleotide adenylyltransferase activity Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. got7fsn_ti polyadenylic acid polymerase activity|polyadenylate polymerase activity|ATP:polynucleotide adenylyltransferase activity|poly-A polymerase activity|ATP:polynucleotidylexotransferase activity|polyadenylic polymerase activity|ATP-polynucleotide adenylyltransferase activity|poly(A) hydrolase activity|poly(A) polymerase activity|RNA adenylating enzyme activity|terminal riboadenylate transferase activity|adenosine triphosphate:ribonucleic acid adenylyltransferase activity|poly(A) synthetase activity|polyadenylate synthetase activity|AMP polynucleotidylexotransferase activity|RNA formation factors, PF1|polyadenylate nucleotidyltransferase activity|NTP polymerase activity MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN|EC:2.7.7.19|RHEA:11332|Reactome:R-HSA-72185 molecular_function owl:Class
GO:0047845 biolink:NamedThing deoxylimonate A-ring-lactonase activity Catalysis of the reaction: deoxylimonoate + H(2)O = deoxylimononate D-ring-lactone + H(+). got7fsn_ti deoxylimonate A-ring-lactonohydrolase activity EC:3.1.1.46|RHEA:14997|MetaCyc:DEOXYLIMONATE-A-RING-LACTONASE-RXN|KEGG_REACTION:R03803 molecular_function owl:Class
GO:0080077 biolink:NamedThing trihydroxyferuloyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a trihydroxyferuloyl spermidine molecule. got7fsn_ti dhl 2009-04-14T04:00:45Z molecular_function owl:Class
GO:0050338 biolink:NamedThing thiosulfate dehydrogenase activity Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c. got7fsn_ti thiosulfate oxidase activity|thiosulfate-acceptor oxidoreductase activity|thiosulphate dehydrogenase activity|thiosulfate:ferricytochrome-c oxidoreductase activity|thiosulfate-oxidizing enzyme|tetrathionate synthase activity RHEA:20549|EC:1.8.2.2|MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0018706 biolink:NamedThing pyrogallol hydroxytransferase activity Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene. got7fsn_ti 1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity|1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity|1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)|1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity|pyrogallol hydroxyltransferase activity|1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity|transhydroxylase activity EC:1.97.1.2|RHEA:21000|MetaCyc:1.97.1.2-RXN|UM-BBD_reactionID:r0006 molecular_function owl:Class
GO:0008460 biolink:NamedThing dTDP-glucose 4,6-dehydratase activity Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O. got7fsn_ti TDP-glucose oxidoreductase activity|dTDPglucose 4,6-hydro-lyase activity|dTDPglucose 4,6-dehydratase activity|dTDP-glucose 4,6-hydro-lyase activity|dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)|thymidine diphosphoglucose oxidoreductase activity RHEA:17221|KEGG_REACTION:R06513|EC:4.2.1.46|MetaCyc:DTDPGLUCDEHYDRAT-RXN molecular_function owl:Class
GO:0047852 biolink:NamedThing diferric-transferrin reductase activity Catalysis of the reaction: transferrin[Fe2+]2 + NAD+ = transferrin[Fe3+]2 + NADH. got7fsn_ti transferrin[Fe(II)]2:NAD+ oxidoreductase activity|transferrin reductase activity|NADH diferric transferrin reductase activity|diferric transferrin reductase activity RHEA:13841|MetaCyc:DIFFERIC-TRANSFERRIN-REDUCTASE-RXN|EC:1.16.1.2 molecular_function owl:Class
GO:0048506 biolink:NamedThing regulation of timing of meristematic phase transition Any process that modulates the rate, frequency or extent of a change in identity of a meristem at a characteristic predetermined time point. got7fsn_ti biological_process owl:Class
GO:0061391 biolink:NamedThing negative regulation of direction of cell growth Any process that decreases the direction of cell growth. got7fsn_ti dph 2011-07-14T10:25:55Z biological_process owl:Class
GO:1900764 biolink:NamedThing emericellin metabolic process The chemical reactions and pathways involving emericellin. got7fsn_ti Variecoxanthone B metabolic process|emericellin metabolism|Variecoxanthone B metabolism di 2012-06-04T09:17:58Z biological_process owl:Class
GO:0102413 biolink:NamedThing 6-O-methyl-deacetylisoipecoside beta-glucosidase activity Catalysis of the reaction: 6-O-methyl-N-deacetylisoipecoside + H2O <=> 6-O-methyl-N-deacetylisoipecoside aglycon + beta-D-glucose. got7fsn_ti MetaCyc:RXN-13791 molecular_function owl:Class
GO:0032342 biolink:NamedThing aldosterone biosynthetic process The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. got7fsn_ti biological_process owl:Class
GO:0021678 biolink:NamedThing third ventricle development The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina. got7fsn_ti biological_process owl:Class
GO:0033650 biolink:NamedThing host cell mitochondrion A semiautonomous, self replicating organelle as found in host cells that occurs in varying numbers, shapes, and sizes in the cell cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti host mitochondria cellular_component owl:Class
GO:0019935 biolink:NamedThing cyclic-nucleotide-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. got7fsn_ti cyclic-nucleotide-mediated signalling biological_process owl:Class
GO:0048927 biolink:NamedThing posterior lateral line neuromast support cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. got7fsn_ti biological_process owl:Class
GO:0048889 biolink:NamedThing neuromast support cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells. got7fsn_ti biological_process owl:Class
GO:0035839 biolink:NamedThing non-growing cell tip A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures. got7fsn_ti new cell end|non-growing cell end bf 2011-05-06T01:32:21Z cellular_component owl:Class
GO:0043447 biolink:NamedThing alkane biosynthetic process The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2. got7fsn_ti alkane biosynthesis|alkane synthesis|alkane formation|alkane anabolism biological_process owl:Class
GO:0062072 biolink:NamedThing H3K9me3 modified histone binding Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation. got7fsn_ti dph 2018-09-05T12:58:43Z molecular_function owl:Class
GO:0035064 biolink:NamedThing methylated histone binding Binding to a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. got7fsn_ti molecular_function owl:Class
GO:0003225 biolink:NamedThing left ventricular trabecular myocardium morphogenesis The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized. got7fsn_ti dph 2009-10-13T10:45:09Z biological_process owl:Class
GO:0043467 biolink:NamedThing regulation of generation of precursor metabolites and energy Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances. got7fsn_ti biological_process owl:Class
GO:0050395 biolink:NamedThing vitexin beta-glucosyltransferase activity Catalysis of the reaction: UDP-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside. got7fsn_ti uridine diphosphoglucose-vitexin 2''-glucosyltransferase activity|vitexin b-glucosyltransferase activity|UDPglucose:vitexin 2''-O-beta-D-glucosyltransferase activity|UDP-glucose:vitexin 2''-O-beta-D-glucosyltransferase activity MetaCyc:VITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN|EC:2.4.1.105|KEGG_REACTION:R03565|RHEA:21956 molecular_function owl:Class
GO:0061579 biolink:NamedThing N-acyl homoserine lactone synthase activity Catalyzing the reaction: acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine -> [acyl-carrier- protein] + S-methyl-5'-thioadenosine + N-acyl-L-homoserine lactone. got7fsn_ti autoinducer-1 synthase dph 2013-11-15T19:48:23Z EC:2.3.1.184|RHEA:10096 molecular_function owl:Class
GO:0004156 biolink:NamedThing dihydropteroate synthase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. got7fsn_ti 7,8-dihydropteroate synthetase activity|DHPS activity|7,8-dihydropteroic acid synthetase activity|dihydropteroate pyrophosphorylase activity|2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity|7,8-dihydropteroate synthase activity|dihydropteroate synthetase activity|(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity|dihydropteroate diphosphorylase activity|dihydropteroic synthetase activity MetaCyc:H2PTEROATESYNTH-RXN|RHEA:19949|EC:2.5.1.15 molecular_function owl:Class
GO:0034826 biolink:NamedThing 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+. got7fsn_ti UM-BBD_reactionID:r1170 molecular_function owl:Class
GO:0102111 biolink:NamedThing gibberellin A20,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A20 + 2-oxoglutarate + O2 <=> gibberellin A29 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-113 molecular_function owl:Class
GO:0042630 biolink:NamedThing behavioral response to water deprivation Any process that results in a change in the behavior of an organism as a result of deprivation of water. got7fsn_ti behavioral response to thirst|behavioral response to drought|behavioural response to water deprivation biological_process owl:Class
GO:0072320 biolink:NamedThing volume-sensitive chloride channel activity Enables the transmembrane transfer of a chloride ion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. got7fsn_ti swell-activated chloride channel mah 2010-10-26T12:53:38Z molecular_function owl:Class
GO:0030038 biolink:NamedThing contractile actin filament bundle assembly Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. got7fsn_ti biological_process owl:Class
GO:0072129 biolink:NamedThing renal capsule formation The developmental process pertaining to the initial formation of a renal capsule from unspecified parts. The renal capsule is the tough fibrous layer surrounding the kidney, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. During development, it comprises a single layer of flattened cells that lie just above the cortical stroma and the condensed mesenchyme of the nephrogenic zone. It is in this region that the early stages of nephron induction and formation of new generations ureteric bud branches occur, as the kidney expands. got7fsn_ti mah 2010-02-22T02:08:14Z biological_process owl:Class
GO:0000413 biolink:NamedThing protein peptidyl-prolyl isomerization The modification of a protein by cis-trans isomerization of a proline residue. got7fsn_ti protein proline isomerization biological_process owl:Class
GO:1903349 biolink:NamedThing omegasome membrane Any membrane that is part of an omegasome. got7fsn_ti pr 2014-08-19T12:33:09Z cellular_component owl:Class
GO:0098588 biolink:NamedThing bounding membrane of organelle The lipid bilayer that forms the outer-most layer of an organelle. got7fsn_ti Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. dos 2014-02-26T13:41:31Z cellular_component owl:Class
GO:0009312 biolink:NamedThing oligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. got7fsn_ti oligosaccharide biosynthesis|oligosaccharide anabolism|oligosaccharide formation|oligosaccharide synthesis biological_process owl:Class
GO:0030750 biolink:NamedThing putrescine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:putrescine N-methyltransferase activity|putrescine methyltransferase activity EC:2.1.1.53|RHEA:15037|KEGG_REACTION:R01153|MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0080129 biolink:NamedThing proteasome core complex assembly The aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles. got7fsn_ti 20S proteasome assembly dhl 2009-04-29T03:34:50Z biological_process owl:Class
GO:0043248 biolink:NamedThing proteasome assembly The aggregation, arrangement and bonding together of a mature, active proteasome complex. got7fsn_ti 26S proteasome assembly|proteasome maturation|proteasome complex assembly biological_process owl:Class
GO:0006174 biolink:NamedThing dADP phosphorylation The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP. got7fsn_ti biological_process owl:Class
GO:0001893 biolink:NamedThing maternal placenta development Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin. got7fsn_ti decidua development biological_process owl:Class
GO:0001866 biolink:NamedThing NK T cell proliferation The expansion of a NK T cell population by cell division. got7fsn_ti NKT cell proliferation|NT cell proliferation|NK T-lymphocyte proliferation|NK T-cell proliferation|natural T cell proliferation|NK T lymphocyte proliferation|natural killer T cell proliferation Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. biological_process owl:Class
GO:0021618 biolink:NamedThing hypoglossal nerve morphogenesis The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. got7fsn_ti CN XII morphogenesis biological_process owl:Class
GO:0021986 biolink:NamedThing habenula development The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland. got7fsn_ti biological_process owl:Class
GO:0031892 biolink:NamedThing type 2 vasoactive intestinal polypeptide receptor binding Binding to a type 2 vasoactive intestinal polypeptide receptor. got7fsn_ti type 2 vasoactive intestinal polypeptide receptor ligand|type 3 PACAP receptor binding molecular_function owl:Class
GO:0031890 biolink:NamedThing vasoactive intestinal polypeptide receptor binding Binding to a vasoactive intestinal polypeptide receptor. got7fsn_ti vasoactive intestinal polypeptide receptor ligand|VIP receptor binding molecular_function owl:Class
GO:0072248 biolink:NamedThing metanephric glomerular visceral epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. got7fsn_ti metanephric podocyte differentiation mah 2010-03-19T03:44:57Z biological_process owl:Class
GO:0031916 biolink:NamedThing regulation of synaptic metaplasticity A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. got7fsn_ti biological_process owl:Class
GO:0047546 biolink:NamedThing 2-hydroxypyridine 5-monooxygenase activity Catalysis of the reaction: 2-hydroxypyridine + AH(2) + O(2) = 2,5-dihydroxypyridine + A + H(2)O. got7fsn_ti 2-hydroxypyridine oxygenase activity|2-hydroxypyridine,hydrogen-donor:oxygen oxidoreductase (5-hydroxylating) MetaCyc:2-HYDROXYPYRIDINE-5-MONOOXYGENASE-RXN|EC:1.14.99.26|KEGG_REACTION:R03206|RHEA:16973 molecular_function owl:Class
GO:0050109 biolink:NamedThing morphine 6-dehydrogenase activity Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+. got7fsn_ti morphine:NAD(P)+ 6-oxidoreductase activity|reductase, naloxone|naloxone reductase activity EC:1.1.1.218|MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0061819 biolink:NamedThing telomeric DNA-containing double minutes formation A telomere maintenance process that results in the formation of small fragments of circular extrachromosomal DNA elements which contain telomeric DNA. It is speculated that telomeric DNA-containing double minutes are formed through a recombination event between the telomere and chromosome-internal TTAGGG-like sequences. Telomeric DNA-containing double minutes appear as two closely positioned dots in metaphase. got7fsn_ti TDMs formation dph 2016-12-20T09:49:03Z biological_process owl:Class
GO:0080104 biolink:NamedThing 5-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 5-methylthiopropyl-glucosinolate = 5-methylsulfinylpropyl-glucosinolate. got7fsn_ti dhl 2009-04-23T04:28:25Z molecular_function owl:Class
GO:0004631 biolink:NamedThing phosphomevalonate kinase activity Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+). got7fsn_ti ATP:5-phosphomevalonate phosphotransferase activity|mevalonic acid phosphate kinase activity|mevalonate phosphate kinase activity|mevalonate-5-phosphate kinase activity|5-phosphomevalonate kinase activity|ATP:(R)-5-phosphomevalonate phosphotransferase activity Reactome:R-HSA-191422|KEGG_REACTION:R03245|MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN|RHEA:16341|EC:2.7.4.2 molecular_function owl:Class
GO:0102720 biolink:NamedThing acetyl-coenzyme A:acetyl alcohol acetyltransferase activity Catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A. got7fsn_ti RHEA:36147|MetaCyc:RXN-6762|EC:2.3.1.224 molecular_function owl:Class
GO:0004833 biolink:NamedThing tryptophan 2,3-dioxygenase activity Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. got7fsn_ti indoleamine-pyrrole 2,3-dioxygenase activity|tryptophan peroxidase activity|tryptophan pyrrolase activity|L-tryptophan pyrrolase activity|L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)|TDO|L-tryptophan 2,3-dioxygenase activity|tryptamin 2,3-dioxygenase activity|indolamine 2,3-dioxygenase activity|tryptamine 2,3-dioxygenase activity|tryptophan oxygenase activity GO:0004426 RHEA:24536|EC:1.13.11.11|Reactome:R-HSA-198563|MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN|Reactome:R-HSA-888614|Reactome:R-HSA-71188 molecular_function owl:Class
GO:0021526 biolink:NamedThing medial motor column neuron differentiation The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:1900591 biolink:NamedThing violaceol II metabolic process The chemical reactions and pathways involving violaceol II. got7fsn_ti violaceol II metabolism di 2012-05-15T06:51:21Z biological_process owl:Class
GO:0070740 biolink:NamedThing tubulin-glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. got7fsn_ti tubulin glutamylase activity|tubulin-glutamate ligase activity mah 2009-06-19T02:26:15Z Reactome:R-HSA-8865774|Reactome:R-HSA-8955869 molecular_function owl:Class
GO:0008494 biolink:NamedThing translation activator activity Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. got7fsn_ti molecular_function owl:Class
GO:0140496 biolink:NamedThing gamma-tubulin complex binding Binding to a gamma-tubulin complex. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19788 pg 2020-07-17T08:14:32Z molecular_function owl:Class
GO:0033180 biolink:NamedThing proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. got7fsn_ti cellular_component owl:Class
GO:0033178 biolink:NamedThing proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. got7fsn_ti cellular_component owl:Class
GO:0070310 biolink:NamedThing ATR-ATRIP complex A protein complex that contains the protein kinase ATR and ATR-interacting protein (ATRIP) and binds single-stranded DNA; ssDNA binding affinity is increased in the presence of replication protein A. got7fsn_ti Rad3-Rad26 complex|Mec1-Lcd1 complex cellular_component owl:Class
GO:0001173 biolink:NamedThing DNA-templated transcriptional start site selection Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. got7fsn_ti DNA-dependent transcriptional start site selection krc 2011-06-20T12:44:11Z biological_process owl:Class
GO:0006973 biolink:NamedThing intracellular accumulation of glycerol The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment. got7fsn_ti biological_process owl:Class
GO:0042373 biolink:NamedThing vitamin K metabolic process The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule. got7fsn_ti naphthoquinone metabolic process|vitamin K metabolism|naphthoquinone metabolism biological_process owl:Class
GO:0106244 biolink:NamedThing eupatolide synthase activity Catalysis of the reaction: 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + O2 + reduced [NADPH--hemoprotein reductase] = eupatolide + 2 H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti hjd 2019-12-20T14:50:15Z RHEA:57972|EC:1.14.14.169 molecular_function owl:Class
GO:0042560 biolink:NamedThing pteridine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. got7fsn_ti pteridine and derivative catabolic process|pteridine-containing compound catabolism|pteridine-containing compound degradation|pterin catabolic process|pterin catabolism|pteridine-containing compound breakdown|pteridine and derivative catabolism biological_process owl:Class
GO:0021963 biolink:NamedThing spinothalamic tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling. got7fsn_ti dorsolateral tract of Lissauer morphogenesis biological_process owl:Class
GO:0061415 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources. got7fsn_ti dph 2012-01-23T11:33:08Z biological_process owl:Class
GO:0016497 biolink:NamedThing substance K receptor activity Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity. got7fsn_ti neuromedin L receptor activity|neurokinin A receptor activity molecular_function owl:Class
GO:0004995 biolink:NamedThing tachykinin receptor activity Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti molecular_function owl:Class
GO:0070187 biolink:NamedThing shelterin complex A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1. got7fsn_ti Pot1-Tpz1 complex|Pot1 complex|telosome cellular_component owl:Class
GO:0009676 biolink:NamedThing low-affinity sulfate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low affinity sulfate:hydrogen symporter activity|low affinity sulfate:proton symporter activity|low affinity sulphate:hydrogen symporter activity molecular_function owl:Class
GO:0008512 biolink:NamedThing sulfate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). got7fsn_ti sulfate:hydrogen symporter activity|sulfate/hydrogen symporter activity|sulphate:hydrogen symporter activity molecular_function owl:Class
GO:0018392 biolink:NamedThing glycoprotein 3-alpha-L-fucosyltransferase activity Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+). got7fsn_ti GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity|GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity|GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity|GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity|GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity|GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity|GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity|GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity|GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity|GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity RHEA:24444|EC:2.4.1.214|KEGG_REACTION:R06015|MetaCyc:2.4.1.214-RXN molecular_function owl:Class
GO:0046920 biolink:NamedThing alpha-(1->3)-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage. got7fsn_ti alpha-(1,3)-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity|alpha-1,3-fucosyltransferase activity Reactome:R-HSA-9605644|Reactome:R-HSA-9605682|Reactome:R-HSA-9603984|Reactome:R-HSA-9605609 molecular_function owl:Class
GO:0018839 biolink:NamedThing cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. got7fsn_ti EC:5.2.1.-|UM-BBD_reactionID:r0163 molecular_function owl:Class
GO:0047723 biolink:NamedThing inosinate nucleosidase activity Catalysis of the reaction: H(2)O + IMP = D-ribose 5-phosphate + hypoxanthine. got7fsn_ti 5'-inosinate phosphoribohydrolase activity RHEA:20469|EC:3.2.2.12|KEGG_REACTION:R01128|MetaCyc:INOSINATE-NUCLEOSIDASE-RXN molecular_function owl:Class
GO:0072331 biolink:NamedThing signal transduction by p53 class mediator An intracellular signaling process that is induced by the cell cycle regulator phosphoprotein p53 or an equivalent protein. got7fsn_ti mah 2010-11-03T01:32:59Z biological_process owl:Class
GO:2000542 biolink:NamedThing negative regulation of gastrulation Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation. got7fsn_ti yaf 2011-04-01T04:10:08Z biological_process owl:Class
GO:0050067 biolink:NamedThing lysine 2-monooxygenase activity Catalysis of the reaction: L-lysine + O(2) = 5-aminopentanamide + CO(2) + H(2)O. got7fsn_ti lysine oxygenase activity|lysine monooxygenase activity|L-lysine:oxygen 2-oxidoreductase (decarboxylating)|L-lysine-2-monooxygenase activity RHEA:14601|EC:1.13.12.2|MetaCyc:LYSINE-2-MONOOXYGENASE-RXN|KEGG_REACTION:R00449 molecular_function owl:Class
GO:0030123 biolink:NamedThing AP-3 adaptor complex A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B). got7fsn_ti cellular_component owl:Class
GO:0007306 biolink:NamedThing eggshell chorion assembly Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell. got7fsn_ti insect chorion formation|eggshell chorion formation biological_process owl:Class
GO:0102109 biolink:NamedThing tricaffeoyl spermidine O-methyltransferase activity Catalysis of the reaction: tricaffeoyl spermidine + 3 S-adenosyl-L-methionine <=> 3 H+ + triferuloyl spermidine + 3 S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-11261 molecular_function owl:Class
GO:0010426 biolink:NamedThing DNA methylation on cytosine within a CHH sequence The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide. got7fsn_ti cytosine methylation within a CHH sequence|cytosine methylation within a CNN sequence|DNA methylation on cytosine within a CNN sequence biological_process owl:Class
GO:0017196 biolink:NamedThing N-terminal peptidyl-methionine acetylation The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine. got7fsn_ti RESID:AA0049 biological_process owl:Class
GO:0043875 biolink:NamedThing 2-ketobutyrate formate-lyase activity Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate. got7fsn_ti KFL|TdcE|keto-acid formate acetyltransferase This function is part of an anaerobic pathway for the catabolism of L-threonine. MetaCyc:KETOBUTFORMLY-RXN molecular_function owl:Class
GO:0061815 biolink:NamedThing deubiquitinase, acting on linear ubiquitin Catalysis of the hydrolysis of ubiquitin units from linear ubiquitin chains. got7fsn_ti linear ubiquitin specific deubiquitinase activity|ubiquitinyl hydrolase activity, acting on linear ubiquitin|Met1 linkage specific DUB dph 2016-11-28T13:58:44Z molecular_function owl:Class
GO:0016495 biolink:NamedThing C-X3-C chemokine receptor activity Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif. got7fsn_ti molecular_function owl:Class
GO:1990623 biolink:NamedThing Herring body The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively. got7fsn_ti neurosecretory body cls 2015-01-29T21:11:54Z cellular_component owl:Class
GO:0007323 biolink:NamedThing peptide pheromone maturation The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae. got7fsn_ti pheromone processing GO:0046613|GO:0007326|GO:0007324 biological_process owl:Class
GO:0102208 biolink:NamedThing 2-polyprenyl-6-hydroxyphenol methylase activity Catalysis of the reaction: S-adenosyl-L-methionine + a 3-(all-trans-polyrenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + H+ + a 2-methoxy-6-(all-trans-polyprenyl)phenol. got7fsn_ti MetaCyc:RXN-12160|RHEA:31411 molecular_function owl:Class
GO:0008744 biolink:NamedThing L-xylulokinase activity Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate. got7fsn_ti L-xylulokinase (phosphorylating)|ATP:L-xylulose 5-phosphotransferase activity|L-xylulose kinase activity EC:2.7.1.53|MetaCyc:LYXK-RXN|RHEA:18869 molecular_function owl:Class
GO:0004856 biolink:NamedThing xylulokinase activity Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+). got7fsn_ti xylulokinase (phosphorylating)|xylulose kinase activity|D-xylulokinase activity|ATP:D-xylulose 5-phosphotransferase activity RHEA:10964|KEGG_REACTION:R01639|EC:2.7.1.17|Reactome:R-HSA-5662466|MetaCyc:XYLULOKIN-RXN molecular_function owl:Class
GO:0052022 biolink:NamedThing modulation by symbiont of jasmonic acid levels in host The alteration by an organism of the levels of jasmonic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of jasmonic acid levels in other organism involved in symbiotic interaction GO:0052456 biological_process owl:Class
GO:0001766 biolink:NamedThing membrane raft polarization The clustering and aggregation of a membrane into domains. This serves as a mechanism to compartmentalize cellular activities and to establish cell polarity. got7fsn_ti membrane polarization|lipid raft polarization https://github.com/geneontology/go-ontology/issues/20666 biological_process owl:Class
GO:0071015 biolink:NamedThing U12-type prespliceosome A spliceosomal complex that is formed by the cooperative binding of the heterodimeric U11/U12 snRNP to the 5' splice site and the branch point sequence. The U12-type prespliceosome includes many proteins in addition to those found in the U11/U12 heterodimeric snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. got7fsn_ti mammalian U12-type spliceosomal complex A|yeast U12-type spliceosomal complex B|minor prespliceosome|AT-AC prespliceosome mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0071010 biolink:NamedThing prespliceosome A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. got7fsn_ti mammalian spliceosomal complex A|prespliceosomal complex|yeast spliceosomal complex B mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0019216 biolink:NamedThing regulation of lipid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids. got7fsn_ti regulation of lipid metabolism biological_process owl:Class
GO:0031918 biolink:NamedThing positive regulation of synaptic metaplasticity A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require. got7fsn_ti activation of synaptic metaplasticity|up-regulation of synaptic metaplasticity|upregulation of synaptic metaplasticity|stimulation of synaptic metaplasticity|up regulation of synaptic metaplasticity biological_process owl:Class
GO:0031915 biolink:NamedThing positive regulation of synaptic plasticity A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. got7fsn_ti activation of synaptic plasticity|stimulation of synaptic plasticity|up-regulation of synaptic plasticity|upregulation of synaptic plasticity|up regulation of synaptic plasticity biological_process owl:Class
GO:1990350 biolink:NamedThing glucose transporter complex A protein complex facilitating glucose transport into, out of or within a cell, or between cells. got7fsn_ti An example of this is GTR1 in human (UniProt symbol P11166) in PMID:15449578 (inferred from direct assay). bhm 2014-03-26T14:12:05Z cellular_component owl:Class
GO:0050213 biolink:NamedThing progesterone 5-alpha-reductase activity Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH. got7fsn_ti delta4-steroid 5alpha-reductase (progesterone)|progesterone 5alpha-reductase activity|progesterone 5a-reductase activity|5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase activity|steroid 5-alpha-reductase activity EC:1.3.1.30|RHEA:21952|MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN molecular_function owl:Class
GO:0045895 biolink:NamedThing positive regulation of mating-type specific transcription, DNA-templated Any mating-type specific process that activates or increases the rate of cellular DNA-templated transcription. got7fsn_ti activation of transcription, mating-type specific|up-regulation of transcription, mating-type specific|upregulation of transcription, mating-type specific|stimulation of transcription, mating-type specific|positive regulation of mating-type specific transcription, DNA-dependent|up regulation of transcription, mating-type specific biological_process owl:Class
GO:0043472 biolink:NamedThing IgD binding Binding to an immunoglobulin of a D isotype. got7fsn_ti molecular_function owl:Class
GO:0052098 biolink:NamedThing formation by host of specialized structure for nutrient acquisition from symbiont The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0052095 biolink:NamedThing formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti formation of specialized structure for nutrient acquisition from other organism during symbiotic interaction biological_process owl:Class
GO:0019704 biolink:NamedThing peptidyl-L-cysteine S-myristoylation The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine. got7fsn_ti peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine|peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine RESID:AA0307 biological_process owl:Class
GO:0018377 biolink:NamedThing protein myristoylation The covalent attachment of a myristoyl group to a protein. got7fsn_ti protein amino acid myristoylation GO:0018319 biological_process owl:Class
GO:0031143 biolink:NamedThing pseudopodium A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding. got7fsn_ti reticulopodium|pseudopodial protrusion|axopodium|lobopodium|pseudopod https://github.com/geneontology/go-ontology/issues/21139|https://github.com/geneontology/go-ontology/issues/21141 Wikipedia:Pseudopod cellular_component owl:Class
GO:0060866 biolink:NamedThing leaf abscission The controlled shedding of a leaf. got7fsn_ti dph 2009-08-12T06:33:55Z biological_process owl:Class
GO:0016509 biolink:NamedThing long-chain-3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. got7fsn_ti long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity|long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity|beta-hydroxyacyl-CoA dehydrogenase activity|LCHAD Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'. Reactome:R-HSA-548818|MetaCyc:1.1.1.211-RXN|EC:1.1.1.211 molecular_function owl:Class
GO:0003857 biolink:NamedThing 3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+). got7fsn_ti L-3-hydroxyacyl CoA dehydrogenase activity|beta-hydroxyacyl dehydrogenase activity|beta-hydroxyacylcoenzyme A dehydrogenase activity|beta-keto-reductase activity|beta-hydroxybutyrylcoenzyme A dehydrogenase activity|3-oxoacyl-thioester reductase activity|L-3-hydroxyacyl coenzyme A dehydrogenase activity|beta-ketoacyl-CoA reductase|beta-hydroxyacyl-coenzyme A synthetase activity See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. Reactome:R-HSA-193508|Reactome:R-HSA-193455|Reactome:R-HSA-6809264|Reactome:R-HSA-70837|Reactome:R-HSA-508369|Reactome:R-HSA-77323|EC:1.1.1.35|Reactome:R-HSA-390251|Reactome:R-HSA-389995|Reactome:R-HSA-77331|UM-BBD_enzymeID:e0664|Reactome:R-HSA-77312|Reactome:R-HSA-77303|Reactome:R-HSA-77254|Reactome:R-HSA-77342|RHEA:22432|Reactome:R-HSA-77283|MetaCyc:OHACYL-COA-DEHYDROG-RXN molecular_function owl:Class
GO:0097202 biolink:NamedThing activation of cysteine-type endopeptidase activity Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase. got7fsn_ti activation of metacaspase activity|activation of caspase activity This term should be used to annotate gene products within the context of cellular processes other than apoptotic cell death (e.g., cell cycle arrest). To annotate gene products involved in activation of cysteine-type endopeptidases where the activation results in apoptotic process, please use the more granular term GO:0006919. pr 2011-12-19T02:44:04Z biological_process owl:Class
GO:2001056 biolink:NamedThing positive regulation of cysteine-type endopeptidase activity Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity. got7fsn_ti positive regulation of thiol endopeptidase activity|positive regulation of lysosomal cysteine-type endopeptidase pr 2011-09-09T08:53:43Z biological_process owl:Class
GO:0002322 biolink:NamedThing B cell proliferation involved in immune response The expansion of a B cell population by cell division following B cell activation during an immune response. got7fsn_ti B-lymphocyte proliferation during immune response|B lymphocyte proliferation during immune response|B cell proliferation during immune response|B-cell proliferation during immune response biological_process owl:Class
GO:0004838 biolink:NamedThing L-tyrosine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate. got7fsn_ti tyrosine-2-ketoglutarate aminotransferase activity|phenylpyruvic acid transaminase activity|L-phenylalanine 2-oxoglutarate aminotransferase activity|tyrosine-alpha-ketoglutarate transaminase activity|phenylalanine transaminase activity|L-tyrosine aminotransferase activity|tyrosine-alpha-ketoglutarate aminotransferase activity|phenylalanine aminotransferase activity|TyrAT activity|glutamic phenylpyruvic aminotransferase activity|tyrosine aminotransferase activity|tyrosine transaminase activity|phenylalanine-alpha-ketoglutarate transaminase activity|phenylpyruvate transaminase activity|glutamic-hydroxyphenylpyruvic transaminase activity EC:2.6.1.5|Reactome:R-HSA-517444|Reactome:R-HSA-71155|RHEA:15093|MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:0070547 biolink:NamedThing L-tyrosine aminotransferase activity Catalysis of the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid. got7fsn_ti molecular_function owl:Class
GO:1990786 biolink:NamedThing cellular response to dsDNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus. got7fsn_ti sl 2015-06-24T22:48:25Z biological_process owl:Class
GO:0010690 biolink:NamedThing negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis. got7fsn_ti biological_process owl:Class
GO:0060567 biolink:NamedThing negative regulation of DNA-templated transcription, termination Any process that decreases the rate, frequency or extent of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. got7fsn_ti negative regulation of termination of DNA-dependent transcription|negative regulation of DNA-dependent transcription, termination|negative regulation of transcription termination, DNA-dependent dph 2009-04-29T02:59:12Z biological_process owl:Class
GO:0090488 biolink:NamedThing polo box domain specific binding Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases. got7fsn_ti tb 2012-10-16T10:47:30Z molecular_function owl:Class
GO:0008890 biolink:NamedThing glycine C-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+). got7fsn_ti 2-amino-3-ketobutyrate-CoA ligase activity|acetyl-CoA:glycine C-acetyltransferase activity|2-amino-3-ketobutyrate CoA ligase activity|glycine acetyltransferase activity|aminoacetone synthase activity|2-amino-3-ketobutyrate coenzyme A ligase activity RHEA:20736|EC:2.3.1.29|KEGG_REACTION:R00371|MetaCyc:AKBLIG-RXN molecular_function owl:Class
GO:0001050 biolink:NamedThing single-subunit type RNA polymerase binding Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. got7fsn_ti T7-type RNA polymerase binding|T3/T7 type RNA polymerase binding|T3-type RNA polymerase binding|SP6-type RNA polymerase binding krc 2010-09-23T02:33:45Z molecular_function owl:Class
GO:0036380 biolink:NamedThing UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol. got7fsn_ti UDP-N-acetyl-D-glucosamine:ditrans,octacis-undecaprenyl phosphate N-acetyl-D-glucosaminephosphotransferase activity|UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity|UDP-GIcNAc:undecaprenyl phosphate N-acetylglucosaminyl 1-P transferase activity|GlcNAc-P-P-Und synthase activity|UDP-N-acetylglucosamine:undecaprenyl-phosphate GlcNAc-1-phosphate transferase activity bf 2013-05-23T10:51:26Z EC:2.7.8.33|KEGG_REACTION:R08856|RHEA:28090|MetaCyc:GLCNACPTRANS-RXN molecular_function owl:Class
GO:0008177 biolink:NamedThing succinate dehydrogenase (ubiquinone) activity Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol. got7fsn_ti succinic dehydrogenase activity|fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)|respiratory complex II|quinol:fumarate oxidoreductase activity|menaquinol: fumarate oxidoreductase activity|succinate:ubiquinone oxidoreductase activity|succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration) GO:0019737 Reactome:R-HSA-163213|MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN|RHEA:13713|KEGG_REACTION:R02164|Reactome:R-HSA-70994|EC:1.3.5.1 molecular_function owl:Class
GO:0032256 biolink:NamedThing establishment of dense core granule localization The directed movement of a dense core granule to a specific location. got7fsn_ti establishment of dense core vesicle localization|establishment of dense core granule localisation biological_process owl:Class
GO:0004790 biolink:NamedThing thioether S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium. got7fsn_ti S-adenosyl-L-methionine:thioether S-methyltransferase activity|S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity|thioether methyltransferase activity MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN|KEGG_REACTION:R02572|EC:2.1.1.96|RHEA:19613 molecular_function owl:Class
GO:0044373 biolink:NamedThing cytokinin binding Binding to a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators. got7fsn_ti jl 2011-12-01T03:42:10Z molecular_function owl:Class
GO:0034561 biolink:NamedThing 1,2-bis(4-hydroxyphenyl)-2-proponol dehydratase activity Catalysis of the reaction: 1,2-bis(4-hydroxyphenyl)-2-propanol = 4,4'-dihydroxy-alpha-methylstilbene + H2O. got7fsn_ti UM-BBD_reactionID:r0862 molecular_function owl:Class
GO:0110056 biolink:NamedThing positive regulation of actin filament annealing Any process that activates or increases the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. got7fsn_ti kmv 2017-09-20T20:13:09Z biological_process owl:Class
GO:0052753 biolink:NamedThing propan-2-ol:coenzyme F420 oxidoreductase activity Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420. got7fsn_ti F420-dependent secondary alcohol dehydrogenase activity|F420-dependent propan-2-ol dehydrogenase activity|isopropanol:coenzyme F420 oxidoreductase activity 2011-09-21T05:15:28Z molecular_function owl:Class
GO:0034920 biolink:NamedThing pyrene dioxygenase activity Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene. got7fsn_ti UM-BBD_reactionID:r0934|EC:1.13.11.- molecular_function owl:Class
GO:0102766 biolink:NamedThing naringenin 7-O-methyltransferase activity Catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine <=> sakuranetin + S-adenosyl-L-homocysteine + H+. got7fsn_ti RHEA:31539|MetaCyc:RXN-7773|EC:2.1.1.232 molecular_function owl:Class
GO:0046379 biolink:NamedThing extracellular polysaccharide metabolic process The chemical reactions and pathways involving polysaccharides used in extracellular structures. got7fsn_ti extracellular polysaccharide metabolism biological_process owl:Class
GO:1990217 biolink:NamedThing suppression by symbiont of host phytoalexin production Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host phytoalexin production ml 2013-10-10T15:49:33Z biological_process owl:Class
GO:0018688 biolink:NamedThing DDT 2,3-dioxygenase activity Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT. got7fsn_ti UM-BBD_reactionID:r0450 molecular_function owl:Class
GO:0071889 biolink:NamedThing 14-3-3 protein binding Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. got7fsn_ti mah 2010-09-14T01:21:50Z molecular_function owl:Class
GO:0060742 biolink:NamedThing epithelial cell differentiation involved in prostate gland development The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell of the prostate gland. got7fsn_ti dph 2009-06-16T09:32:34Z biological_process owl:Class
GO:0008055 biolink:NamedThing ocellus pigment biosynthetic process The chemical reactions and pathways resulting in the formation of ocellus pigments, general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates. got7fsn_ti ocellus pigment biosynthesis|ocellus pigment anabolism|ocellus pigment formation|ocellus pigment synthesis biological_process owl:Class
GO:0044294 biolink:NamedThing dendritic growth cone The migrating motile tip of a growing nerve cell dendrite. got7fsn_ti dendrite growth cone jl 2010-02-04T03:45:27Z NIF_Subcellular:sao1594955670 cellular_component owl:Class
GO:0031875 biolink:NamedThing type 4 proteinase activated receptor binding Binding to a type 4 proteinase activated receptor. got7fsn_ti type 4 proteinase activated receptor ligand molecular_function owl:Class
GO:1990631 biolink:NamedThing ErbB-4 class receptor binding Binding to the protein-tyrosine kinase receptor ErbB-4/HER4. got7fsn_ti HER4 receptor binding sl 2015-02-06T23:28:49Z molecular_function owl:Class
GO:0080166 biolink:NamedThing stomium development The process whose specific outcome is the progression of the stomium over time, from its formation to the mature structure. A stomium is a fissure or pore in the anther lobe through which the pollen is released. got7fsn_ti dhl 2010-09-23T05:03:40Z biological_process owl:Class
SO:0000833 biolink:NamedThing got7fsn_ti owl:Class
GO:0042729 biolink:NamedThing DASH complex A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the outer kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability. got7fsn_ti Duo1p-Dam1p-Dad1p complex|Dam1 complex|condensed nuclear chromosome kinetochore-associated DASH complex|DDD complex https://github.com/geneontology/go-ontology/issues/21126 Note that this complex is conserved in fungi but has not been observed in metazoans. GO:0043926|GO:0043925 cellular_component owl:Class
GO:0071945 biolink:NamedThing regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed A process that modulates flagellum-dependent motility in bacteria by modulating the speed or direction of rotation of a rotary flagellar motor, mediated by interactions between the braking protein. got7fsn_ti regulation of bacterial-type flagellum cell motility by regulation of motor speed|regulation of bacterial-type flagellar cell motility by regulation of motor speed|regulation of flagellar cell motility by regulation of motor speed mah 2010-10-05T04:10:27Z biological_process owl:Class
GO:1902021 biolink:NamedThing regulation of bacterial-type flagellum-dependent cell motility Any process that modulates the frequency, rate or extent of bacterial-type flagellum-dependent cell motility. got7fsn_ti regulation of bacterial-type flagellum cell motility|regulation of flagellin-based flagellar cell motility|regulation of bacterial-type flagellar cell motility jl 2013-03-27T14:42:50Z biological_process owl:Class
GO:0035844 biolink:NamedThing cloaca development The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates. got7fsn_ti cloacal development bf 2011-05-06T01:54:35Z biological_process owl:Class
GO:0047283 biolink:NamedThing dolichyl-phosphate D-xylosyltransferase activity Catalysis of the reaction: dolichol-phosphate + UDP-D-xylose = dolichyl D-xylosyl phosphate + UDP. got7fsn_ti UDP-D-xylose:dolichyl-phosphate D-xylosyltransferase activity RHEA:15361|EC:2.4.2.32|MetaCyc:2.4.2.32-RXN molecular_function owl:Class
GO:0035252 biolink:NamedThing UDP-xylosyltransferase activity Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. got7fsn_ti Reactome:R-HSA-9638090|Reactome:R-HSA-5617138|Reactome:R-HSA-6785668 molecular_function owl:Class
GO:0003358 biolink:NamedThing noradrenergic neuron development The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti norepinephrine secreting neuron development dph 2009-12-03T10:38:37Z biological_process owl:Class
GO:0061262 biolink:NamedThing mesonephric renal vesicle formation The developmental process pertaining to the initial formation of the mesonephros. got7fsn_ti mesonephros formation dph 2010-08-30T02:41:20Z biological_process owl:Class
GO:0005139 biolink:NamedThing interleukin-7 receptor binding Binding to an interleukin-7 receptor. got7fsn_ti IL-7|interleukin-7 receptor ligand molecular_function owl:Class
GO:0042426 biolink:NamedThing choline catabolic process The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. got7fsn_ti choline breakdown|choline degradation|choline catabolism biological_process owl:Class
GO:0033877 biolink:NamedThing succinyl-CoA:(R)-benzylsuccinate CoA-transferase activity Catalysis of the reaction: (R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate. got7fsn_ti succinyl-CoA:benzylsuccinate CoA-transferase activity|benzylsuccinate CoA-transferase activity|succinyl-CoA:(R)-2-benzylsuccinate CoA-transferase activity GO:0018728 UM-BBD_reactionID:r0329|MetaCyc:RXN-864|KEGG_REACTION:R05588|RHEA:16469|EC:2.8.3.15 molecular_function owl:Class
GO:0140473 biolink:NamedThing telomere-nuclear envelope anchor activity The binding activity of a molecule that brings together the telomeric region of a chromosome and the inner nuclear membrane by interacting with both the telomere and the nuclear membrane, in order to establish and maintain the telomeric location. got7fsn_ti telomere-nuclear envelope anchoring activity|nuclear envelope-telomere anchor activity https://github.com/geneontology/go-ontology/issues/19229 pg 2020-06-19T15:44:44Z molecular_function owl:Class
GO:0050098 biolink:NamedThing methylguanidinase activity Catalysis of the reaction: H(2)O + methylguanidine = methylammonium + urea. got7fsn_ti methylguanidine hydrolase activity|methylguanidine amidinohydrolase activity MetaCyc:METHYLGUANIDINASE-RXN|KEGG_REACTION:R01589|EC:3.5.3.16|RHEA:11764 molecular_function owl:Class
GO:0102870 biolink:NamedThing 7-hydroxyflavone-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 7-hydroxyflavone <=> 7-O-beta-D-glucosyl-7-hydroxyflavone + UDP + H+. got7fsn_ti MetaCyc:RXN-8355 molecular_function owl:Class
GO:0051085 biolink:NamedThing chaperone cofactor-dependent protein refolding The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. got7fsn_ti chaperone cofactor-dependent 'de novo' protein folding|chaperone co-factor-dependent protein refolding|chaperone co-factor-dependent protein folding|chaperone cofactor-dependent protein folding|chaperone mediated protein folding requiring cofactor https://github.com/geneontology/go-ontology/issues/10726 GO:0070389 biological_process owl:Class
GO:0051084 biolink:NamedThing 'de novo' posttranslational protein folding The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis. got7fsn_ti 'de novo' post-translational protein folding biological_process owl:Class
GO:0038135 biolink:NamedThing ERBB2-ERBB4 signaling pathway A series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4. got7fsn_ti HER2-HER4 signaling pathway|ERBB2-ERBB4 signalling pathway bf 2012-03-30T11:19:52Z biological_process owl:Class
GO:0140453 biolink:NamedThing protein aggregate center Reversible aggregate of misfolded proteins and chaperones formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. got7fsn_ti protein aggregate centre|PAC https://github.com/geneontology/go-ontology/issues/19172 pg 2020-04-20T15:21:55Z cellular_component owl:Class
GO:0097009 biolink:NamedThing energy homeostasis Any process involved in the balance between food intake (energy input) and energy expenditure. got7fsn_ti negative regulation of energy homeostasis|regulation of energy homeostasis|positive regulation of energy homeostasis pr 2011-03-21T10:52:44Z GO:2000506|GO:2000507|GO:2000505 biological_process owl:Class
GO:0038059 biolink:NamedThing IKKalpha-IKKalpha complex A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits. got7fsn_ti IKKalpha homodimer|IKKalpha homodimeric complex|IkappaB kinase-alpha homodimer|IkappaB kinase alpha homodimer|IKKalpha-IKKalpha protein complex bf 2012-01-10T09:29:53Z cellular_component owl:Class
GO:0072534 biolink:NamedThing perineuronal net A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain. got7fsn_ti PNN mah 2011-01-14T01:37:40Z cellular_component owl:Class
GO:0106143 biolink:NamedThing tRNA (m7G46) methyltransferase complex A protein complex involved in the catalysis of the formation of the modified nucleotide 7-methylguanine (at position 46 in certain tRNAs, such as tRNA(phe) and tRNA(met). In yeast, it is a heterotetramer of two subunits, Trm8 (catalytic) and Trm82 (WD repeat). got7fsn_ti tRNA (m7G46) methyltransferase|tRNA m7G methylation complex|Trm8-Trm82 complex hjd 2018-09-07T14:53:29Z cellular_component owl:Class
GO:0002106 biolink:NamedThing endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. got7fsn_ti biological_process owl:Class
GO:0033512 biolink:NamedThing L-lysine catabolic process to acetyl-CoA via saccharopine The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate saccharopine. got7fsn_ti L-lysine degradation to acetyl-CoA via saccharopine|L-lysine breakdown to acetyl-CoA via saccharopine MetaCyc:LYSINE-DEG1-PWY biological_process owl:Class
GO:0090057 biolink:NamedThing root radial pattern formation The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis. got7fsn_ti tb 2009-08-11T02:58:06Z biological_process owl:Class
GO:0009956 biolink:NamedThing radial pattern formation The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur. got7fsn_ti radial pattern specification biological_process owl:Class
GO:0060108 biolink:NamedThing annular furrow extracellular matrix The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline. got7fsn_ti cellular_component owl:Class
GO:0106095 biolink:NamedThing m7G(5')pppN diphosphatase complex A homodimeric protein complex that catalyzes the reaction: 7-methylguanosine-5'-triphospho-5'-pholynucleotide + H20 = 7-methylguanosine-5'-phosphate + polynucleotide. got7fsn_ti 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase enzyme|M(7)G(5')pppN pyrophosphatase enzyme|m7G(5')pppN pyrophosphatase enzyme|m7G(5')pppN diphosphatase enzyme|DCS1 decapping scavenger complex hjd 2018-02-07T17:52:03Z cellular_component owl:Class
GO:1903293 biolink:NamedThing phosphatase complex A protein complex which is capable of phosphatase activity. got7fsn_ti An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay). bhm 2014-08-13T10:25:32Z cellular_component owl:Class
GO:0003069 biolink:NamedThing acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure. got7fsn_ti vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure biological_process owl:Class
GO:0009763 biolink:NamedThing NAD-malic enzyme C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme. got7fsn_ti biological_process owl:Class
GO:0007329 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter by pheromones Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter. got7fsn_ti positive regulation of transcription from Pol II promoter by pheromones|up-regulation of transcription from RNA polymerase II promoter by pheromones|upregulation of transcription from RNA polymerase II promoter by pheromones|activation of transcription from RNA polymerase II promoter by pheromones|up regulation of transcription from RNA polymerase II promoter by pheromones|stimulation of transcription from RNA polymerase II promoter by pheromones biological_process owl:Class
GO:0038136 biolink:NamedThing ERBB3-ERBB4 signaling pathway A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti HER3-HER4 signaling pathway|ERBB3-ERBB4 signalling pathway bf 2012-03-30T11:21:19Z biological_process owl:Class
GO:0090497 biolink:NamedThing mesenchymal cell migration The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism. got7fsn_ti tb 2012-10-17T12:08:17Z biological_process owl:Class
GO:0047215 biolink:NamedThing indole-3-acetate beta-glucosyltransferase activity Catalysis of the reaction: (indol-3-yl)acetate + UDP-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP. got7fsn_ti UDPglucose:indole-3-acetate beta-D-glucosyltransferase activity|indol-3-ylacetylglucose synthase activity|IAGlu synthase activity|UDP-glucose:(indol-3-yl)acetate beta-D-glucosyltransferase activity|UDPG-indol-3-ylacetyl glucosyl transferase activity|uridine diphosphoglucose-indoleacetate glucosyltransferase activity|IAA-glucose synthase activity|UDP-glucose:indol-3-ylacetate glucosyltransferase activity|IAA-Glu synthetase activity|UDP-glucose:indol-3-ylacetate glucosyl-transferase activity|UDP-glucose:indol-3-acetic acid glucosyltransferase activity|UDP-glucose:auxin glucosyltransferase activity RHEA:14921|EC:2.4.1.121|MetaCyc:2.4.1.121-RXN|KEGG_REACTION:R03094 molecular_function owl:Class
GO:1990243 biolink:NamedThing atf1-pcr1 complex A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE). got7fsn_ti al 2013-11-28T11:40:28Z cellular_component owl:Class
GO:0035976 biolink:NamedThing transcription factor AP-1 complex A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. got7fsn_ti Activating protein 1 complex|AP-1 complex|AP1 complex|transcription factor AP1 complex bf 2011-08-17T10:57:51Z cellular_component owl:Class
GO:0051312 biolink:NamedThing chromosome decondensation The alteration of chromosome structure from the condensed form to a relaxed disperse form. got7fsn_ti biological_process owl:Class
GO:0048171 biolink:NamedThing negative regulation of long-term neuronal synaptic plasticity A process that decreases long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers. got7fsn_ti down regulation of long-term neuronal synaptic plasticity|inhibition of long-term neuronal synaptic plasticity|downregulation of long-term neuronal synaptic plasticity|down-regulation of long-term neuronal synaptic plasticity Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:0051762 biolink:NamedThing sesquiterpene biosynthetic process The chemical reactions and pathways resulting in the formation of sesquiterpenes, any of a class of terpenes of the formula C15H24 or a derivative of such a terpene. got7fsn_ti biological_process owl:Class
GO:0140363 biolink:NamedThing TIS granule A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER). got7fsn_ti pg 2019-07-25T19:20:58Z cellular_component owl:Class
GO:0102989 biolink:NamedThing 5-pentadecatrienylresorcinol synthase activity Catalysis of the reaction: 3 H+ + 9,12,15-cis-hexadecatrienoyl-CoA + 3 malonyl-CoA(5-) <=> 5-(pentadeca-8,11,14-trien-1-yl)resorcinol + 4 coenzyme A + 4 carbon dioxide. got7fsn_ti MetaCyc:RXN-9618 molecular_function owl:Class
GO:0008988 biolink:NamedThing rRNA (adenine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine. got7fsn_ti S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity|ErmC 23S rRNA methyltransferase|gene ksgA methyltransferase|ribonucleic acid-adenine (N6) methylase activity|S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity|ribosomal ribonucleate adenine 6-methyltransferase activity|ribonucleic acid-adenine (N(6)) methylase activity molecular_function owl:Class
GO:0071924 biolink:NamedThing chemokine (C-C motif) ligand 22 production The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti C-C motif chemokine 22 production|CCL22 production|CCL-22 production mah 2010-09-28T11:33:13Z biological_process owl:Class
GO:0050692 biolink:NamedThing DNA binding domain binding Binding to a protein's DNA binding domain (DBD). got7fsn_ti DBD binding molecular_function owl:Class
GO:0036379 biolink:NamedThing myofilament Any of the smallest contractile units of a myofibril (striated muscle fiber). got7fsn_ti striated muscle filament bf 2013-05-22T14:39:06Z cellular_component owl:Class
GO:0048670 biolink:NamedThing regulation of collateral sprouting Any process that modulates the frequency, rate or extent of collateral sprouting. got7fsn_ti biological_process owl:Class
GO:0046761 biolink:NamedThing viral budding from plasma membrane A viral budding that starts with formation of a membrane curvature in the host plasma membrane. got7fsn_ti virus budding from plasma membrane by viral capsid envelopment|virus budding from plasma membrane|viral budding from plasma membrane during viral capsid envelopment|plasma membrane viral budding|viral budding from plasma membrane by viral capsid envelopment|plasma membrane viral budding during viral capsid envelopment|virus budding from plasma membrane during viral capsid envelopment GO:0046767|GO:0046766 biological_process owl:Class
GO:0018561 biolink:NamedThing 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0457 molecular_function owl:Class
GO:0033193 biolink:NamedThing Lsd1/2 complex A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast. got7fsn_ti Swm1/2 complex|SAPHIRE complex|Swm complex cellular_component owl:Class
GO:0097658 biolink:NamedThing Asi complex A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p. got7fsn_ti pr 2014-09-29T15:08:29Z cellular_component owl:Class
GO:0102891 biolink:NamedThing 2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 2',3,4,4',6'-pentahydroxychalcone <=> H+ + 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP. got7fsn_ti MetaCyc:RXN-8455|EC:2.4.1.286|RHEA:34295 molecular_function owl:Class
GO:0060878 biolink:NamedThing pouch outgrowth involved in semicircular canal formation The morphogenetic process in which an epithelial sheet bends along a linear axis and gives rise to a pouch that will form a semicircular canal. got7fsn_ti dph 2009-08-13T10:01:01Z biological_process owl:Class
GO:0050150 biolink:NamedThing o-pyrocatechuate decarboxylase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2). got7fsn_ti 2,3-dihydroxybenzoate decarboxylase activity|2,3-dihydroxybenzoate carboxy-lyase activity|2,3-DHBA decarboxylase activity|2,3-dihydroxybenzoate carboxy-lyase (catechol-forming)|2,3-dihydroxybenzoic acid decarboxylase activity GO:0018790 EC:4.1.1.46|RHEA:21492|MetaCyc:O-PYROCATECHUATE-DECARBOXYLASE-RXN|KEGG_REACTION:R00821|UM-BBD_reactionID:r0579 molecular_function owl:Class
GO:0047912 biolink:NamedThing galacturonokinase activity Catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H(+). got7fsn_ti galacturonokinase (phosphorylating) D-galacturonic acid kinase activity|ATP:D-galacturonate 1-phosphotransferase activity MetaCyc:GALACTURONOKINASE-RXN|RHEA:12965|EC:2.7.1.44|KEGG_REACTION:R01980 molecular_function owl:Class
GO:0033538 biolink:NamedThing ajugose biosynthetic process using galactan:galactan galactosyltransferase The chemical reactions and pathways resulting in the formation of ajugose, the hexasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside, by a pathway in which galactan:galactan galactosyltransferase catalyzes chain elongation by transferring the alpha-galactosyl residue of one raffinose-family oligosaccharide to another. got7fsn_ti ajugose formation using galactan:galactan galactosyltransferase|ajugose anabolism using galactan:galactan galactosyltransferase|ajugose biosynthesis using galactan:galactan galactosyltransferase|ajugose synthesis using galactan:galactan galactosyltransferase MetaCyc:PWY-5343 biological_process owl:Class
GO:0048510 biolink:NamedThing regulation of timing of transition from vegetative to reproductive phase The process controlling the point in time during development when a vegetative meristem will change its identity to become an inflorescence or floral meristem, and/or the rate at which the change occurs. got7fsn_ti biological_process owl:Class
GO:0102983 biolink:NamedThing xylogalacturonan beta-1,3-xylosyltransferase activity Catalysis of the reaction: UDP-alpha-D-xylose + a homogalacturonan <=> UDP + 4 H+ + a xylogalacturonan. got7fsn_ti EC:2.4.2.41|MetaCyc:RXN-9589 molecular_function owl:Class
GO:0007396 biolink:NamedThing suture of dorsal opening Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole. got7fsn_ti biological_process owl:Class
GO:0070041 biolink:NamedThing rRNA (uridine-C5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing C5-methyluridine. got7fsn_ti molecular_function owl:Class
GO:0052847 biolink:NamedThing inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+. got7fsn_ti ai 2011-12-05T11:02:23Z MetaCyc:RXN-10975 molecular_function owl:Class
GO:1902103 biolink:NamedThing negative regulation of metaphase/anaphase transition of meiotic cell cycle Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. got7fsn_ti down-regulation of metaphase/anaphase transition of meiotic cell cycle|down regulation of meiotic metaphase/anaphase transition|negative regulation of meiotic metaphase/anaphase transition|down regulation of metaphase/anaphase transition of meiotic cell cycle|downregulation of metaphase/anaphase transition of meiotic cell cycle|inhibition of meiotic metaphase/anaphase transition|downregulation of meiotic metaphase/anaphase transition|down-regulation of meiotic metaphase/anaphase transition|inhibition of metaphase/anaphase transition of meiotic cell cycle jl 2013-05-02T12:45:43Z biological_process owl:Class
GO:1905133 biolink:NamedThing negative regulation of meiotic chromosome separation Any process that stops, prevents or reduces the frequency, rate or extent of meiotic chromosome separation. got7fsn_ti negative regulation of meiotic chromosome resolution|downregulation of meiotic chromosome resolution|down regulation of meiotic chromosome resolution|down regulation of meiotic chromosome separation|downregulation of meiotic chromosome separation|inhibition of meiotic chromosome resolution|down regulation of chromosome separation during meiosis|down-regulation of meiotic chromosome separation|down-regulation of meiotic chromosome resolution|inhibition of meiotic chromosome separation|downregulation of chromosome separation during meiosis|inhibition of chromosome separation during meiosis|negative regulation of chromosome separation during meiosis|down-regulation of chromosome separation during meiosis dph 2016-04-12T17:46:37Z biological_process owl:Class
GO:0006482 biolink:NamedThing protein demethylation The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. got7fsn_ti protein amino acid demethylation biological_process owl:Class
GO:0050140 biolink:NamedThing nitrate reductase (cytochrome) activity Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite. got7fsn_ti ferrocytochrome:nitrate oxidoreductase activity|benzyl viologen-nitrate reductase activity MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN|EC:1.9.6.1|RHEA:12909 molecular_function owl:Class
GO:0016677 biolink:NamedThing oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group. got7fsn_ti oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor EC:1.9.6.- molecular_function owl:Class
GO:1990272 biolink:NamedThing anti-Mullerian hormone receptor activity Combining with anti-Mullerian hormone to initiate a change in cell activity. got7fsn_ti An example of this is Amdh2 in M. musculus, UniprotKB:Q8K592-1 in PMID:23624077. hjd 2014-01-14T21:41:35Z molecular_function owl:Class
GO:0050615 biolink:NamedThing 1,2-dihydrovomilenine reductase activity Catalysis of the reaction: 17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + H(+) + NADPH. got7fsn_ti 17-O-acetylnorajmaline:NADP+ oxidoreductase activity KEGG_REACTION:R05879|RHEA:12320|EC:1.3.1.73|MetaCyc:1.3.1.73-RXN molecular_function owl:Class
GO:0043512 biolink:NamedThing inhibin A complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit. got7fsn_ti Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. cellular_component owl:Class
GO:0043511 biolink:NamedThing inhibin complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B. got7fsn_ti Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. cellular_component owl:Class
GO:0052893 biolink:NamedThing N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide. got7fsn_ti polyamine oxidase (propane-1,3-diamine-forming) activity RHEA:25996|MetaCyc:RXN-10465|EC:1.5.3.14 molecular_function owl:Class
GO:0048815 biolink:NamedThing hermaphrodite genitalia morphogenesis The process in which the anatomical structures of hermaphrodite genitalia are generated and organized. got7fsn_ti biological_process owl:Class
GO:0036397 biolink:NamedThing formate dehydrogenase (quinone) activity Catalysis of the reaction: formate + a quinone = CO2 + a quinol. got7fsn_ti Fdh-N activity|formate:quinone oxidoreductase activity|formate dehydrogenase-N activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.1.5.6. bf 2013-07-18T13:11:41Z MetaCyc:FORMATEDEHYDROG-RXN|EC:1.17.5.3|KEGG_REACTION:R09494|RHEA:48592 molecular_function owl:Class
GO:0008877 biolink:NamedThing glucose-1-phosphatase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate. got7fsn_ti alpha-D-glucose-1-phosphate phosphohydrolase activity|D-glucose-1-phosphate phosphohydrolase activity KEGG_REACTION:R00304|MetaCyc:GLUCOSE-1-PHOSPHAT-RXN|RHEA:19933|EC:3.1.3.10 molecular_function owl:Class
GO:0061428 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter in response to hypoxia Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. got7fsn_ti dph 2012-02-06T09:26:05Z biological_process owl:Class
GO:0070265 biolink:NamedThing necrotic cell death A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. got7fsn_ti necrosis|cellular necrosis Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'. biological_process owl:Class
GO:1900609 biolink:NamedThing F-9775A metabolic process The chemical reactions and pathways involving F-9775A. got7fsn_ti F-9775A metabolism di 2012-05-15T07:02:27Z biological_process owl:Class
GO:0070358 biolink:NamedThing actin polymerization-dependent cell motility A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell. got7fsn_ti cell motility by actin tail formation biological_process owl:Class
GO:0032589 biolink:NamedThing neuron projection membrane The portion of the plasma membrane surrounding a neuron projection. got7fsn_ti cellular_component owl:Class
GO:0044722 biolink:NamedThing renal phosphate excretion The elimination by an organism of phosphate ions in the urine. got7fsn_ti renal phosphate ion excretion jl 2012-10-18T14:54:00Z biological_process owl:Class
GO:1990933 biolink:NamedThing microtubule cytoskeleton attachment to nuclear envelope A process in which the microtubule cytoskeleton is attached to the nuclear envelope. got7fsn_ti vw 2016-03-17T08:32:37Z biological_process owl:Class
GO:0018677 biolink:NamedThing pentachlorophenol monooxygenase activity Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride. got7fsn_ti pentachlorophenol dehalogenase activity|pentachlorophenol hydroxylase activity|PcpB|pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)|pentachlorophenol dechlorinase activity|PCB4MO activity|PCP hydroxylase activity|PCB 4-monooxygenase activity|pentachlorophenol 4-monooxygenase activity RHEA:18685|EC:1.14.13.50|UM-BBD_enzymeID:e0148|MetaCyc:PCP4MONO-RXN molecular_function owl:Class
GO:0090346 biolink:NamedThing cellular organofluorine metabolic process The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells. got7fsn_ti tb 2010-06-02T10:36:42Z biological_process owl:Class
GO:0090345 biolink:NamedThing cellular organohalogen metabolic process The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells. got7fsn_ti tb 2010-06-02T10:36:42Z biological_process owl:Class
GO:0005011 biolink:NamedThing macrophage colony-stimulating factor receptor activity Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. got7fsn_ti CSF-1|M-CSF receptor activity|macrophage colony stimulating factor receptor activity|Fms molecular_function owl:Class
GO:1990984 biolink:NamedThing tRNA demethylase activity Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule. got7fsn_ti sp 2016-10-28T08:38:14Z molecular_function owl:Class
GO:1990321 biolink:NamedThing collagen type XXII trimer A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts. got7fsn_ti bhm 2014-03-14T16:50:05Z cellular_component owl:Class
GO:0043765 biolink:NamedThing T/G mismatch-specific endonuclease activity Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine. got7fsn_ti DNA mismatch endonuclease|very short patch repair protein|V.EcoKDcm|Vsr mismatch endonuclease molecular_function owl:Class
GO:0048832 biolink:NamedThing specification of plant organ number The regionalization process that modulates the quantity of a particular type of plant organ. got7fsn_ti biological_process owl:Class
GO:0006702 biolink:NamedThing androgen biosynthetic process The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. got7fsn_ti androgen biosynthesis|androgen synthesis|androgen formation|androgen anabolism biological_process owl:Class
GO:0070397 biolink:NamedThing wall teichoic acid metabolic process The chemical reactions and pathways involving wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. got7fsn_ti wall teichoic acid metabolism|WTA metabolic process biological_process owl:Class
GO:0046395 biolink:NamedThing carboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. got7fsn_ti carboxylic acid catabolism|carboxylic acid breakdown|carboxylic acid degradation biological_process owl:Class
GO:0007095 biolink:NamedThing mitotic G2 DNA damage checkpoint signaling A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage. got7fsn_ti regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|signal transduction involved in mitotic G2 DNA damage checkpoint|mitotic G2 DNA damage checkpoint|down-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|negative regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|G2 DNA damage checkpoint|positive regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|negative regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|signal transduction involved in mitotic G2/M transition DNA damage checkpoint|down regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|down regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|signal transduction involved in G2 DNA damage checkpoint|regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint|inhibition of signal transduction involved in mitotic G2 DNA damage checkpoint|positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|signal transduction involved in G2/M transition DNA damage checkpoint|down-regulation of signal transduction involved in mitotic G2 DNA damage checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|G2/M transition DNA damage checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072434|GO:0031572|GO:1902504|GO:0072425|GO:1902505|GO:1902506 biological_process owl:Class
GO:0010991 biolink:NamedThing negative regulation of SMAD protein complex assembly Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins. got7fsn_ti tb 2009-06-03T11:30:44Z biological_process owl:Class
GO:0015953 biolink:NamedThing pyrimidine nucleotide interconversion The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide. got7fsn_ti biological_process owl:Class
GO:0006220 biolink:NamedThing pyrimidine nucleotide metabolic process The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti pyrimidine metabolism|pyrimidine nucleotide metabolism|pyrimidine metabolic process biological_process owl:Class
GO:0106173 biolink:NamedThing COPII-coated vesicle lumen The volume enclosed by the membrane of a COPII-coated endocytic vesicle. got7fsn_ti hjd 2019-02-11T18:16:22Z cellular_component owl:Class
GO:0000805 biolink:NamedThing X chromosome The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males. got7fsn_ti Wikipedia:X_chromosome cellular_component owl:Class
GO:0102046 biolink:NamedThing 3,4-dichlorobenzoate-4,5-oxygenase activity Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor <=> 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-10427 molecular_function owl:Class
GO:0018124 biolink:NamedThing peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue. got7fsn_ti RESID:AA0233 biological_process owl:Class
GO:0009446 biolink:NamedThing putrescine biosynthetic process The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine. got7fsn_ti putrescine synthesis|putrescine formation|putrescine biosynthesis|putrescine anabolism biological_process owl:Class
GO:0050349 biolink:NamedThing triacetate-lactonase activity Catalysis of the reaction: H(2)O + triacetate lactone = triacetate. got7fsn_ti triacetolactone lactonohydrolase activity|triacetate lactone hydrolase activity|triacetic acid lactone hydrolase activity|triacetic lactone hydrolase activity|TAL hydrolase activity EC:3.1.1.38|MetaCyc:TRIACETATE-LACTONASE-RXN|RHEA:22260|KEGG_REACTION:R03702 molecular_function owl:Class
GO:0010387 biolink:NamedThing COP9 signalosome assembly The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome. got7fsn_ti signalosome assembly biological_process owl:Class
GO:0001907 biolink:NamedThing killing by symbiont of host cells Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti pathogenesis biological_process owl:Class
GO:0080134 biolink:NamedThing regulation of response to stress Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. dhl 2009-05-06T04:51:28Z biological_process owl:Class
GO:0030422 biolink:NamedThing production of siRNA involved in RNA interference Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference. got7fsn_ti production of guide RNAs involved in RNA interference|RNA interference, production of guide RNAs|RNA interference, production of siRNA biological_process owl:Class
GO:0008690 biolink:NamedThing 3-deoxy-manno-octulosonate cytidylyltransferase activity Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. got7fsn_ti CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity|CMP-2-keto-3-deoxyoctulosonic acid synthetase activity|cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity|2-keto-3-deoxyoctonate cytidylyltransferase activity|CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity|CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity|CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity|CMP-3-deoxy-D-manno-octulosonate synthetase activity|CMP-KDO synthetase activity|CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity|3-deoxy-D-manno-octulosonate cytidylyltransferase activity MetaCyc:CPM-KDOSYNTH-RXN|EC:2.7.7.38|RHEA:23448 molecular_function owl:Class
GO:0046721 biolink:NamedThing formic acid secretion The controlled release of formic acid, HCOOH, by a cell or a tissue. got7fsn_ti formate secretion biological_process owl:Class
GO:0071120 biolink:NamedThing alpha4-beta1 integrin-CD47 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell surface antigen CD47. got7fsn_ti ITGA4-ITGB1-CB47 complex mah 2009-11-13T02:21:10Z cellular_component owl:Class
GO:0071189 biolink:NamedThing protocadherin-alpha-v7-protocadherin-gamma-a3 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a3, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdha7-Pcdhga3 complex mah 2009-11-23T04:24:28Z cellular_component owl:Class
GO:0102448 biolink:NamedThing rhamnetin 4'-O-methyltransferase activity Catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> ombuin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-13934 molecular_function owl:Class
GO:0015640 biolink:NamedThing peptidoglycan peptide transmembrane transporter activity Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains. got7fsn_ti muropeptide transporter activity|murein peptide transporter activity molecular_function owl:Class
GO:0015647 biolink:NamedThing peptidoglycan transmembrane transporter activity Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other. got7fsn_ti murein transporter activity molecular_function owl:Class
GO:0009246 biolink:NamedThing enterobacterial common antigen biosynthetic process The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. got7fsn_ti enterobacterial common antigen biosynthesis|enterobacterial common antigen formation|enterobacterial common antigen synthesis|enterobacterial common antigen anabolism MetaCyc:ECASYN-PWY biological_process owl:Class
GO:0043478 biolink:NamedThing pigment accumulation in response to UV light The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus. got7fsn_ti biological_process owl:Class
GO:0098925 biolink:NamedThing retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0036319 biolink:NamedThing mating-type M-factor pheromone receptor activity Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus. got7fsn_ti M-factor receptor activity|M-factor mating pheromone receptor activity bf 2012-08-30T16:51:12Z molecular_function owl:Class
GO:0000154 biolink:NamedThing rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. got7fsn_ti rRNA editing The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. GO:0016548 biological_process owl:Class
GO:0047861 biolink:NamedThing diiodotyrosine transaminase activity Catalysis of the reaction: 2-oxoglutarate + 3,5-diiodo-L-tyrosine = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + L-glutamate. got7fsn_ti diiodotyrosine aminotransferase activity|halogenated tyrosine aminotransferase activity|3,5-diiodo-L-tyrosine:2-oxoglutarate aminotransferase activity|halogenated tyrosine transaminase activity KEGG_REACTION:R03207|RHEA:19781|EC:2.6.1.24|MetaCyc:DIIODOTYROSINE-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:0010282 biolink:NamedThing senescence-associated vacuole A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast. got7fsn_ti senescence associated vacuole cellular_component owl:Class
GO:0030891 biolink:NamedThing VCB complex A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1. got7fsn_ti pVHL-elongin C-elongin B complex|VHL complex|von Hippel-Lindau tumor suppressor complex cellular_component owl:Class
GO:0000153 biolink:NamedThing cytoplasmic ubiquitin ligase complex A ubiquitin ligase complex found in the cytoplasm. got7fsn_ti cellular_component owl:Class
GO:0050271 biolink:NamedThing S-alkylcysteine lyase activity Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate. got7fsn_ti S-alkyl-L-cysteine lyase activity|alkyl cysteine lyase activity|S-alkyl-L-cysteine sulfoxide lyase activity|S-alkyl-L-cysteine alkylthiol-lyase (deaminating) activity|alkylcysteine lyase activity|S-alkylcysteinase activity|S-alkyl-L-cysteinase activity|S-alkyl-L-cysteine alkylthiol-lyase (deaminating; pyruvate-forming) MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN|RHEA:22424|EC:4.4.1.6 molecular_function owl:Class
GO:0000107 biolink:NamedThing imidazoleglycerol-phosphate synthase activity Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+). got7fsn_ti imidazole-glycerol-phosphate synthase activity|glutamine amidotransferase:cyclase activity|imidazole glycerol phosphate synthase activity|imidazoleglycerol phosphate synthase activity RHEA:24793|MetaCyc:GLUTAMIDOTRANS-RXN molecular_function owl:Class
GO:0038151 biolink:NamedThing CCL2-activated CCR2 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CCL2/CCR2 signaling pathway bf 2012-05-11T11:41:58Z biological_process owl:Class
GO:0047233 biolink:NamedThing N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-beta-D-galactosaminyl-1,4-(N-acetyl-alpha-neuraminyl-2,3)-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. got7fsn_ti UDP-N-acetyl-D-galactosamine:N-acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,4-N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-acetylneuraminyl(alpha2->3)galactosyl(beta1->4)glucosyl beta1->4-acetylgalactosaminyltransferase activity RHEA:13569|MetaCyc:2.4.1.165-RXN|EC:2.4.1.165 molecular_function owl:Class
GO:0099528 biolink:NamedThing G protein-coupled neurotransmitter receptor activity Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G-protein coupled neurotransmitter receptor activity molecular_function owl:Class
GO:0061480 biolink:NamedThing response to asparaginase Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus. got7fsn_ti dph 2012-11-07T09:13:08Z biological_process owl:Class
GO:1990634 biolink:NamedThing protein phosphatase 5 binding Binding to protein phosphatase 5. got7fsn_ti protein phosphatase T binding sl 2015-02-10T21:30:41Z molecular_function owl:Class
GO:0046592 biolink:NamedThing polyamine oxidase activity Catalysis of the oxidative degradation or interconversion of polyamines. got7fsn_ti N1-acetylspermidine:oxygen oxidoreductase (deaminating)|1-N-acetylspermidine:oxygen oxidoreductase (deaminating) MetaCyc:POLYAMINE-OXIDASE-RXN molecular_function owl:Class
GO:0016847 biolink:NamedThing 1-aminocyclopropane-1-carboxylate synthase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+). got7fsn_ti aminocyclopropanecarboxylic acid synthase activity|S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)|ACC synthase activity|1-aminocyclopropanecarboxylate synthase activity|L-VG deaminase activity|S-adenosyl-L-methionine methylthioadenosine-lyase activity|1-aminocyclopropane-1-carboxylate synthetase activity|aminocyclopropanecarboxylate synthase activity|1-aminocyclopropane-1-carboxylic acid synthase activity|L-vinylglycine deaminase activity Note that this function was formerly EC:4.1.99.4. GO:0034100 RHEA:21744|EC:4.4.1.14|MetaCyc:4.4.1.14-RXN|KEGG_REACTION:R00179 molecular_function owl:Class
GO:0008324 biolink:NamedThing cation transmembrane transporter activity Enables the transfer of cation from one side of a membrane to the other. got7fsn_ti transmembrane cation transporter activity molecular_function owl:Class
GO:0044473 biolink:NamedThing envenomation resulting in negative regulation of calcium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism. got7fsn_ti jl 2012-01-19T02:19:46Z biological_process owl:Class
GO:0032023 biolink:NamedThing trypsinogen activation The proteolytic processing of trypsinogen to the active form, trypsin. got7fsn_ti cleavage of trypsinogen to trypsin biological_process owl:Class
GO:0098725 biolink:NamedThing symmetric cell division Cell division in which both daughter cells are of the same type. got7fsn_ti biological_process owl:Class
GO:0098900 biolink:NamedThing regulation of action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti The ion channels through which current flows during an action potential should be annotated to the process 'action potential'. Gene products involved in modulating the characteristics of an action potential via changing the expression levels or the activity of these channels (e.g. modulating their kinetics or voltage sensitivity) should be annotated to this regulation term. biological_process owl:Class
GO:0051292 biolink:NamedThing nuclear pore complex assembly The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex. got7fsn_ti nuclear pore biosynthesis|nuclear pore formation|NPC assembly|nuclear pore complex formation|nuclear pore complex biogenesis|nuclear pore biogenesis|nuclear pore assembly|nuclear pore complex biosynthesis biological_process owl:Class
GO:0102896 biolink:NamedThing colnelenate synthase activity Catalysis of the reaction: (10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate <=> colnelenate + H2O. got7fsn_ti RHEA:28178|MetaCyc:RXN-8498 molecular_function owl:Class
GO:0048672 biolink:NamedThing positive regulation of collateral sprouting Any process that activates or increases the frequency, rate or extent of collateral sprouting. got7fsn_ti stimulation of collateral sprouting|up-regulation of collateral sprouting|activation of collateral sprouting|up regulation of collateral sprouting|upregulation of collateral sprouting biological_process owl:Class
GO:0050772 biolink:NamedThing positive regulation of axonogenesis Any process that activates or increases the frequency, rate or extent of axonogenesis. got7fsn_ti up regulation of axonogenesis|stimulation of axonogenesis|up-regulation of axonogenesis|upregulation of axonogenesis|activation of axonogenesis biological_process owl:Class
GO:0010689 biolink:NamedThing negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus. got7fsn_ti biological_process owl:Class
GO:0140239 biolink:NamedThing postsynaptic endocytosis A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. got7fsn_ti https://github.com/geneontology/synapse/issues/230 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T07:38:27Z biological_process owl:Class
GO:0042403 biolink:NamedThing thyroid hormone metabolic process The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. got7fsn_ti thyroid hormone metabolism biological_process owl:Class
GO:0031289 biolink:NamedThing actin phosphorylation The transfer of one or more phosphate groups to an actin molecule. got7fsn_ti biological_process owl:Class
GO:0140469 biolink:NamedThing GCN2-mediated signaling A series of reactions in which a signal is passed on to downstream proteins within the cell via GCN2 (also known as EIF2AK4), an intracellular protein kinase that is activated by stress signals, such as amino acid starvation. got7fsn_ti regulation of eIF2 alpha phosphorylation by amino acid starvation|EIF2AK4-mediated signaling https://github.com/geneontology/go-ontology/issues/15399|https://github.com/geneontology/go-ontology/issues/19153 pg 2020-05-26T08:47:25Z GO:0060733 biological_process owl:Class
GO:0102559 biolink:NamedThing protein-(glutamine-N5) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a [release factor]-L-glutamine = S-adenosyl-L-homocysteine + H+ + a [release factor]-N5-methyl-L-glutamine. got7fsn_ti MetaCyc:RXN-14992|EC:2.1.1.297|RHEA:42896 molecular_function owl:Class
GO:0042123 biolink:NamedThing glucanosyltransferase activity Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation. got7fsn_ti molecular_function owl:Class
GO:0002269 biolink:NamedThing leukocyte activation involved in inflammatory response A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response. got7fsn_ti immune cell activation during inflammatory response|leukocyte activation during inflammatory response biological_process owl:Class
GO:0051634 biolink:NamedThing inhibition of acetylcholine uptake Any process that prevents the activation of the directed movement of acetylcholine into a cell. got7fsn_ti inhibition of acetylcholine import biological_process owl:Class
GO:0002077 biolink:NamedThing acrosome matrix dispersal The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane. got7fsn_ti biological_process owl:Class
GO:0021729 biolink:NamedThing superior reticular formation development The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0031038 biolink:NamedThing myosin II filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules. got7fsn_ti myosin II polymerization or depolymerization|myosin II filament assembly or disassembly|myosin II filament organisation biological_process owl:Class
GO:0021796 biolink:NamedThing cerebral cortex regionalization The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops. got7fsn_ti cerebral cortex pattern formation|cerebral cortex pattern biosynthesis|cerebral cortex arealization biological_process owl:Class
GO:0043265 biolink:NamedThing ectoplasm Granule free cytoplasm, lying immediately below the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0030497 biolink:NamedThing fatty acid elongation The elongation of a fatty acid chain by the sequential addition of two-carbon units. got7fsn_ti biological_process owl:Class
GO:0046165 biolink:NamedThing alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. got7fsn_ti alcohol biosynthesis|alcohol anabolism|alcohol formation|alcohol synthesis biological_process owl:Class
GO:0008391 biolink:NamedThing arachidonic acid monooxygenase activity Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. got7fsn_ti cytochrome P450 CYP2B19 molecular_function owl:Class
GO:0071569 biolink:NamedThing protein ufmylation Covalent attachment of the ubiquitin-like protein UFM1 to another protein. got7fsn_ti mah 2010-01-20T04:12:01Z biological_process owl:Class
GO:0034082 biolink:NamedThing type II polyketide synthase complex A polyketide synthase complex that consists of several different polypeptide chains, each of which catalyzes a single reaction. got7fsn_ti type II polyketide synthase|type II PKS|type II PKS complex cellular_component owl:Class
GO:0003047 biolink:NamedThing regulation of systemic arterial blood pressure by epinephrine The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine. got7fsn_ti blood pressure regulation by epinephrine|regulation of blood pressure by adrenaline biological_process owl:Class
GO:0051699 biolink:NamedThing proline oxidase activity Catalysis of the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2. got7fsn_ti RHEA:26124|MetaCyc:RXN-821 molecular_function owl:Class
GO:0030947 biolink:NamedThing regulation of vascular endothelial growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. got7fsn_ti regulation of VEGF receptor signaling pathway|regulation of VEGF receptor signalling pathway|regulation of vascular endothelial growth factor receptor signalling pathway biological_process owl:Class
GO:0090287 biolink:NamedThing regulation of cellular response to growth factor stimulus Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus. got7fsn_ti tb 2010-02-18T03:01:25Z biological_process owl:Class
GO:0070501 biolink:NamedThing poly-gamma-glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds. got7fsn_ti poly-gamma-glutamate formation|poly-gamma-glutamate synthesis|poly-gamma-glutamate anabolism|poly-gamma-glutamate biosynthesis biological_process owl:Class
GO:0048156 biolink:NamedThing tau protein binding Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. got7fsn_ti molecular_function owl:Class
GO:0060818 biolink:NamedThing inactivation of paternal X chromosome by genetic imprinting Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on the paternal X-chromosome in the XX sex by genetic imprinting. got7fsn_ti dph 2009-08-11T10:52:31Z biological_process owl:Class
GO:0072063 biolink:NamedThing short descending thin limb development The process whose specific outcome is the progression of the short descending thin limb over time, from its formation to the mature structure. The short descending thin limb is the descending thin limb of a short nephron that has a squamous epithelial morphology. got7fsn_ti mah 2010-01-25T04:12:39Z biological_process owl:Class
GO:0046290 biolink:NamedThing isoflavonoid phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection. got7fsn_ti isoflavonoid phytoalexin catabolism|isoflavonoid phytoalexin breakdown|isoflavonoid phytoalexin degradation biological_process owl:Class
GO:0046288 biolink:NamedThing isoflavonoid catabolic process The chemical reactions and pathways resulting in the breakdown of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids. got7fsn_ti isoflavonoid breakdown|isoflavonoid catabolism|isoflavonoid degradation biological_process owl:Class
GO:0039591 biolink:NamedThing suppression by virus of host tapasin activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host tapasin (TAP binding protein/TAPBP) activity. Tapasin is a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response. got7fsn_ti inhibition of host TAPBP by virus|inhibition of host tapasin by virus|suppression by virus of host TAP binding protein Consider also annotating to 'tapasin binding ; GO:0046980'. bf 2012-06-25T01:27:48Z VZ:818 biological_process owl:Class
GO:0046776 biolink:NamedThing suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules. got7fsn_ti negative regulation by virus of MHC class I cell surface presentation|suppression by virus of MHC class I cell surface presentation in host|major histocompatibility complex|inhibition of host MHC class I molecule presentation by virus|suppression by virus of host MHC class I cell surface presentation VZ:819 biological_process owl:Class
GO:0036216 biolink:NamedThing cellular response to stem cell factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus. got7fsn_ti cellular response to KIT ligand|cellular response to SCF|cellular response to KITLG|cellular response to hematopoietic growth factor KL bf 2012-04-27T10:30:53Z biological_process owl:Class
GO:1901994 biolink:NamedThing negative regulation of meiotic cell cycle phase transition Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle phase transition. got7fsn_ti downregulation of cell cycle transition|inhibition of cell cycle transition|negative regulation of cell cycle transition|down regulation of meiotic cell cycle phase transition|down-regulation of cell cycle transition|down-regulation of meiotic cell cycle phase transition|down regulation of cell cycle transition|downregulation of meiotic cell cycle phase transition|inhibition of meiotic cell cycle phase transition jl 2013-03-19T16:15:03Z biological_process owl:Class
GO:0035780 biolink:NamedThing CD80 biosynthetic process The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival. got7fsn_ti CD80 synthesis|CD80 formation|CD80 biosynthesis|CD80 anabolism bf 2011-04-04T11:18:41Z biological_process owl:Class
GO:0047098 biolink:NamedThing Latia-luciferin monooxygenase (demethylating) activity Catalysis of the reaction: 2 O2 + donor-H2 + Latia luciferin = light + H2O + acceptor + formate + CO2 + oxidized Latia luciferin. got7fsn_ti Latia-luciferin,hydrogen-donor:oxygen oxidoreductase (demethylating)|Latia luciferin monooxygenase (demethylating)|luciferase (Latia luciferin) MetaCyc:1.14.99.21-RXN|RHEA:12677|EC:1.14.99.21 molecular_function owl:Class
GO:0031757 biolink:NamedThing Edg-4 lysophosphatidic acid receptor binding Binding to an Edg-4 lysophosphatidic acid receptor. got7fsn_ti Edg-4 lysophosphatidic acid receptor ligand|LPA2 receptor binding molecular_function owl:Class
GO:0008979 biolink:NamedThing prophage integrase activity Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA. got7fsn_ti integrase activity involved in establishment of integrated proviral latency molecular_function owl:Class
GO:0009009 biolink:NamedThing site-specific recombinase activity Catalysis of the formation of new phosphodiester bonds between a pair of short, unique target DNA sequences. got7fsn_ti RecA-family recombinase activity https://github.com/geneontology/go-ontology/issues/3917 Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds. molecular_function owl:Class
GO:0036446 biolink:NamedThing myofibroblast differentiation The process in which an undifferentiated cell acquires the features of a myofibroblast cell. got7fsn_ti myofibroblast cell differentiation bf 2013-10-30T10:06:51Z biological_process owl:Class
GO:0099002 biolink:NamedThing viral genome ejection through host cell envelope, short tail mechanism Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm via a short tail ejection system consisting a central tube, the connector which attaches the tail to the phage capsid and releases inner core proteins. Upon binding to the host cell surface, the phage displays a tube-like extension of its short tail that penetrates both host membranes. This tail extension comes from the release of viral core proteins with channel forming properties. got7fsn_ti viral short tail ejection system VZ:3954 biological_process owl:Class
GO:0140043 biolink:NamedThing lipid droplet localization to prospore membrane leading edge Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge. got7fsn_ti lipid body localization to ascospore-type prospore membrane leading edge|adiposome localization to forespore membrane leading edge|lipid body localization to FSM membrane leading edge|adiposome localization to ascospore-type prospore membrane leading edge|adiposome localization to FSM membrane leading edge|lipid particle localization to FSM membrane leading edge|lipid particle localization to ascospore-type prospore membrane leading edge|lipid particle localization to forespore membrane leading edge|lipid body localization to forespore membrane leading edge pg 2017-06-19T09:20:13Z biological_process owl:Class
GO:0030221 biolink:NamedThing basophil differentiation The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell. got7fsn_ti basophil cell differentiation biological_process owl:Class
GO:0060414 biolink:NamedThing aorta smooth muscle tissue morphogenesis The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body. got7fsn_ti biological_process owl:Class
GO:0043185 biolink:NamedThing vascular endothelial growth factor receptor 3 binding Binding to a vascular endothelial growth factor receptor 3. got7fsn_ti VEGF receptor 3 binding|VEGFR 3 binding|fms-like-tyrosine kinase (Flt)-4 binding molecular_function owl:Class
GO:0000224 biolink:NamedThing peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. got7fsn_ti N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity|glycopeptide N-glycosidase activity|glycopeptidase activity|jack-bean glycopeptidase|PNGase F|N-oligosaccharide glycopeptidase activity|peptide:N-glycanase|N-glycanase activity|PNGase A|PNGase Reactome:R-HSA-8850594|MetaCyc:3.5.1.52-RXN|EC:3.5.1.52 molecular_function owl:Class
GO:0043441 biolink:NamedThing acetoacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. got7fsn_ti acetoacetic acid formation|acetoacetic acid synthesis|acetoacetic acid anabolism|acetoacetic acid biosynthesis biological_process owl:Class
GO:0051790 biolink:NamedThing short-chain fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than C6. got7fsn_ti short-chain fatty acid formation|short chain fatty acid biosynthetic process|short-chain fatty acid anabolism|short-chain fatty acid synthesis|short-chain fatty acid biosynthesis|short chain fatty acid biosynthesis biological_process owl:Class
GO:1990343 biolink:NamedThing heterochromatin domain A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me). got7fsn_ti HOOD An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin domains preferentially assemble at sexual differentiation genes and retrotransposons. mah 2014-03-21T15:40:48Z cellular_component owl:Class
GO:0045903 biolink:NamedThing positive regulation of translational fidelity Any process that increases the ability of the translational apparatus to interpret the genetic code. got7fsn_ti up regulation of translational fidelity|activation of translational fidelity|upregulation of translational fidelity|up-regulation of translational fidelity|stimulation of translational fidelity biological_process owl:Class
GO:0052102 biolink:NamedThing positive regulation by symbiont of defense-related host calcium-dependent protein kinase pathway Any process in which an organism activates, maintains or increases the frequency, rate or extent of the host calcium-dependent protein kinase pathway during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti upregulation by symbiont of defense-related host calcium-dependent protein kinase pathway|positive regulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction|up regulation by symbiont of defense-related host calcium-dependent protein kinase pathway|stimulation by symbiont of defense-related host calcium-dependent protein kinase pathway|up-regulation by symbiont of defense-related host calcium-dependent protein kinase pathway|positive regulation of defense-related host CDPK pathway by organism|activation by symbiont of defense-related host calcium-dependent protein kinase pathway GO:0052287 biological_process owl:Class
GO:0016309 biolink:NamedThing 1-phosphatidylinositol-5-phosphate 4-kinase activity Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. got7fsn_ti 1-phosphatidylinositol-5-phosphate kinase|ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity|type II PIP kinase activity|PIP4K Reactome:R-HSA-6811522|Reactome:R-HSA-1675776|EC:2.7.1.149|RHEA:12280|MetaCyc:2.7.1.149-RXN molecular_function owl:Class
GO:0090135 biolink:NamedThing actin filament branching The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments. got7fsn_ti tb 2009-12-08T01:53:14Z biological_process owl:Class
GO:0051356 biolink:NamedThing visual perception involved in equilibrioception The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity. got7fsn_ti perception of orientation with respect to gravity by visual perception|equilibrioception by visual perception|visual perception during equilibrioception biological_process owl:Class
GO:0007601 biolink:NamedThing visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. got7fsn_ti sense of sight|sensory visual perception|vision Wikipedia:Visual_perception biological_process owl:Class
GO:0017180 biolink:NamedThing peptidyl-diphthine biosynthetic process from peptidyl-histidine The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine. got7fsn_ti peptidyl-diphthine anabolism from peptidyl-histidine|peptidyl-diphthine formation from peptidyl-histidine|peptidyl-diphthine synthesis from peptidyl-histidine biological_process owl:Class
GO:0035291 biolink:NamedThing specification of segmental identity, intercalary segment The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti See also the fly_anatomy.ontology term 'intercalary segment ; FBbt:00000010'. biological_process owl:Class
GO:0097702 biolink:NamedThing response to oscillatory fluid shear stress Any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis. got7fsn_ti pr 2016-01-27T14:17:08Z biological_process owl:Class
GO:0046333 biolink:NamedThing octopamine metabolic process The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. got7fsn_ti octopamine metabolism biological_process owl:Class
GO:0019398 biolink:NamedThing gallate catabolic process via gallate dioxygenase activity The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase. got7fsn_ti gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate|gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate|gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate|gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate|gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate MetaCyc:GALLATE-DEGRADATION-II-PWY biological_process owl:Class
GO:0042195 biolink:NamedThing aerobic gallate catabolic process The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen. got7fsn_ti aerobic gallic acid catabolism|aerobic gallate degradation|aerobic gallate breakdown|aerobic gallic acid catabolic process|aerobic gallate catabolism biological_process owl:Class
GO:0007492 biolink:NamedThing endoderm development The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues. got7fsn_ti biological_process owl:Class
GO:0007185 biolink:NamedThing transmembrane receptor protein tyrosine phosphatase signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti transmembrane receptor protein tyrosine phosphatase signalling pathway biological_process owl:Class
GO:0007167 biolink:NamedThing enzyme linked receptor protein signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti enzyme linked receptor protein signalling pathway biological_process owl:Class
GO:0099539 biolink:NamedThing neuropeptide secretion from presynapse The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration. got7fsn_ti neuropeptide secretion from presynapse via dense core granule exocytosis biological_process owl:Class
GO:0047402 biolink:NamedThing protein-glucosylgalactosylhydroxylysine glucosidase activity Catalysis of the reaction: H2O + protein alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine = protein beta-D-galactosyl-L-hydroxylysine + beta-D-glucose. The enzyme specifically hydrolyzes glucose from alpha-D-glucosyl- (1->2)-beta-D-galactosyl disaccharide units that are linked to hydroxylysine residues of collagen and collagen-like proteins. got7fsn_ti 2-O-alpha-D-glucopyranosyl-5-O-alpha-D-galactopyranosylhydroxy-L-lysine glucohydrolase activity|protein-alpha-D-glucosyl-1,2-beta-D-galactosyl-L-hydroxylysine glucohydrolase activity MetaCyc:3.2.1.107-RXN|RHEA:11068|EC:3.2.1.107 molecular_function owl:Class
GO:0016437 biolink:NamedThing tRNA cytidylyltransferase activity Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1). got7fsn_ti tRNA adenylyl(cytidylyl)transferase|tRNA CCA-diphosphorylase activity|tRNA CCA-pyrophosphorylase activity|CTP(ATP):tRNA nucleotidyltransferase|ATP(CTP)-tRNA nucleotidyltransferase|ribonucleic cytidylyltransferase|ATP (CTP):tRNA nucleotidyltransferase|transfer ribonucleate nucleotidyltransferase|ribonucleic cytidylic cytidylic adenylic pyrophosphorylase|transfer ribonucleate adenylyltransferase|transfer ribonucleic acid nucleotidyl transferase|CTP:tRNA cytidylyltransferase activity|-C-C-A pyrophosphorylase|ATP(CTP):tRNA nucleotidyltransferase activity|transfer ribonucleic-terminal trinucleotide nucleotidyltransferase|transfer RNA adenylyltransferase|transfer ribonucleic adenylyl (cytidylyl) transferase|transfer ribonucleate cytidylyltransferase|transfer-RNA nucleotidyltransferase EC:2.7.7.72|MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN molecular_function owl:Class
GO:0001596 biolink:NamedThing angiotensin type I receptor activity An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. got7fsn_ti PLC-activating angiotensin receptor activity molecular_function owl:Class
GO:0000036 biolink:NamedThing acyl carrier activity Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis. got7fsn_ti ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process molecular_function owl:Class
GO:0018607 biolink:NamedThing 1-indanone monooxygenase activity Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin. got7fsn_ti UM-BBD_reactionID:r0417|EC:1.14.12.- molecular_function owl:Class
GO:0051433 biolink:NamedThing BH2 domain binding Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists. got7fsn_ti molecular_function owl:Class
GO:0035812 biolink:NamedThing renal sodium excretion The elimination by an organism of sodium in the urine. got7fsn_ti bf 2011-04-20T01:24:16Z biological_process owl:Class
GO:0050414 biolink:NamedThing formimidoylaspartate deiminase activity Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3. got7fsn_ti N-formimidoyl-L-aspartate iminohydrolase activity|formiminoaspartate deiminase activity MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN|EC:3.5.3.5|RHEA:13661 molecular_function owl:Class
GO:0032393 biolink:NamedThing MHC class I receptor activity Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. got7fsn_ti T cell receptor activity|gamma-delta T cell receptor activity|alpha-beta T cell receptor activity Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves. molecular_function owl:Class
GO:0097246 biolink:NamedThing catechin binding Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure. got7fsn_ti pr 2012-02-17T03:53:54Z molecular_function owl:Class
GO:0097245 biolink:NamedThing flavanol binding Binding to a flavanol. got7fsn_ti flavan-3-ol binding pr 2012-02-17T03:52:10Z molecular_function owl:Class
GO:0030643 biolink:NamedThing cellular phosphate ion homeostasis Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell. got7fsn_ti biological_process owl:Class
GO:0072502 biolink:NamedThing cellular trivalent inorganic anion homeostasis Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell. got7fsn_ti Note that this term was split from 'cellular di-, tri-valent inorganic anion homeostasis ; GO:0030319' (sibling term 'cellular divalent inorganic anion homeostasis' ; GO:0072501'). mah 2010-12-16T12:53:42Z biological_process owl:Class
GO:0106282 biolink:NamedThing isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity Catalysis of the reaction: 3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + H(+) + NADH. got7fsn_ti hjd 2020-07-29T17:51:00Z RHEA:42024 molecular_function owl:Class
GO:0019400 biolink:NamedThing alditol metabolic process The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. got7fsn_ti alditol metabolism biological_process owl:Class
GO:0010270 biolink:NamedThing photosystem II oxygen evolving complex assembly The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on a thylakoid membrane. The OEC protects the calcium-4 manganese-5 oxide cluster which is bound to the D1 and CP43 proteins. The exact protein composition of the OEC varies between cyanobacteria and plants, and in plants consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ. got7fsn_ti OEC (PSII) ASSEMBLY biological_process owl:Class
GO:0018732 biolink:NamedThing sulfolactone hydrolase activity Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate. got7fsn_ti sulpholactone hydrolase activity EC:3.1.1.92|UM-BBD_reactionID:r0583 molecular_function owl:Class
GO:0008882 biolink:NamedThing [glutamate-ammonia-ligase] adenylyltransferase activity Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]. got7fsn_ti glutamate-ammonia-ligase adenylyltransferase activity|adenosine triphosphate:glutamine synthetase adenylyltransferase activity|ATP:glutamine synthetase adenylyltransferase activity|glutamine-synthetase adenylyltransferase activity|ATP:[glutamate-ammonia-ligase] adenylyltransferase activity|ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity MetaCyc:GSADENYLATION-RXN|EC:2.7.7.42|RHEA:18589 molecular_function owl:Class
GO:0102584 biolink:NamedThing cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity Catalysis of the reaction: cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP-alpha-D-glucose <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-15330 molecular_function owl:Class
GO:0052774 biolink:NamedThing glucosyl-N-acetylglucosamine glucosaminidase activity Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine. got7fsn_ti ai 2011-10-03T12:01:05Z molecular_function owl:Class
GO:0080169 biolink:NamedThing cellular response to boron-containing substance deprivation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of boron obtained from boron-containing substances. got7fsn_ti cellular response to boron starvation|cellular response to boron deprivation dhl 2010-09-23T05:10:00Z biological_process owl:Class
GO:0045051 biolink:NamedThing protein insertion into ER membrane by internal uncleaved signal-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences. got7fsn_ti protein-endoplasmic reticulum insertion by internal uncleaved signal-anchor sequence|protein insertion into ER membrane, internal uncleaved signal-anchor sequence mediated|internal uncleaved signal-anchor sequence mediated protein insertion into ER membrane|protein-ER insertion by internal uncleaved signal-anchor sequence|protein insertion into endoplasmic reticulum membrane by internal uncleaved signal-anchor sequence biological_process owl:Class
GO:0045771 biolink:NamedThing negative regulation of autophagosome size Any process that reduces autophagosome size. got7fsn_ti down-regulation of autophagic vacuole size|down regulation of autophagic vacuole size|downregulation of autophagic vacuole size|inhibition of autophagic vacuole size|negative regulation of autophagic vacuole size biological_process owl:Class
GO:0097419 biolink:NamedThing Pick body Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E. got7fsn_ti pr 2012-11-06T20:57:02Z NIF_Subcellular:nlx_subcell_20090102 cellular_component owl:Class
GO:0110050 biolink:NamedThing deaminated glutathione amidase activity Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H(2)O = 2-oxoglutarate + L-cysteinylglycine. got7fsn_ti N-(4-oxoglutarate)-L-cysteinylglycine = deaminated glutathione kmv 2017-08-31T19:19:11Z molecular_function owl:Class
GO:0102707 biolink:NamedThing S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity Catalysis of the reaction: beta-alanine + S-adenosyl-L-methionine = H+ + N-methyl-beta-alanine + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.49|MetaCyc:RXN-6461 molecular_function owl:Class
GO:0071961 biolink:NamedThing mitotic sister chromatid cohesion, arms The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during mitosis. got7fsn_ti sister chromatid cohesion along arms at mitosis|mitotic sister chromatid cohesion along arms mah 2011-06-02T11:21:13Z biological_process owl:Class
GO:0007064 biolink:NamedThing mitotic sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission. got7fsn_ti biological_process owl:Class
GO:0071465 biolink:NamedThing cellular response to desiccation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. got7fsn_ti desiccation tolerance mah 2009-12-18T11:35:19Z biological_process owl:Class
GO:0070715 biolink:NamedThing sodium-dependent organic cation transport The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti mah 2009-06-09T03:26:27Z biological_process owl:Class
GO:0045734 biolink:NamedThing regulation of acetate catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. got7fsn_ti regulation of acetate degradation|regulation of acetate breakdown|regulation of acetate catabolism biological_process owl:Class
GO:0016513 biolink:NamedThing core-binding factor complex A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit. got7fsn_ti PEPB2 complex|CBF complex|AML1 complex cellular_component owl:Class
GO:0075132 biolink:NamedThing suppression by symbiont of host protein kinase-mediated signal transduction Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host protein kinase-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "negative regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075101". biological_process owl:Class
GO:0021645 biolink:NamedThing vagus nerve structural organization The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. got7fsn_ti vagus nerve structural organisation|CN X structural organization biological_process owl:Class
GO:0070437 biolink:NamedThing Grb2-Shc complex A protein complex that contains Grb2 and the adaptor protein Shc, and is involved in linking epidermal growth factor receptor (EGFR) activation to the p21-Ras pathway. got7fsn_ti Grb2-Shc complex, EGF stimulated cellular_component owl:Class
GO:0004723 biolink:NamedThing calcium-dependent protein serine/threonine phosphatase activity Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. got7fsn_ti calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity|calcineurin GO:0008596 Reactome:R-HSA-2025882 molecular_function owl:Class
GO:0008254 biolink:NamedThing 3'-nucleotidase activity Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate. got7fsn_ti 3'-ribonucleotidase activity|3' nucleotidase activity|3'-ribonucleotide phosphohydrolase activity|3'-phosphatase activity|3'-mononucleotidase activity RHEA:10144|EC:3.1.3.6|MetaCyc:3-NUCLEOTID-RXN molecular_function owl:Class
GO:0098534 biolink:NamedThing centriole assembly A cellular process that results in the assembly of one or more centrioles. got7fsn_ti dos 2013-10-22T15:55:22Z biological_process owl:Class
GO:0034441 biolink:NamedThing plasma lipoprotein particle oxidation The modification of a lipid or protein within a plasma lipoprotein particle by oxidation of the lipid or one or more amino acids. got7fsn_ti plasma lipoprotein oxidation biological_process owl:Class
GO:0034369 biolink:NamedThing plasma lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a plasma lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the esterification of cholesterol by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). got7fsn_ti biological_process owl:Class
GO:0017105 biolink:NamedThing acyl-CoA delta11-desaturase activity Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O. The enzyme introduces a cis double bond at position C-11 of saturated fatty acyl-CoAs. got7fsn_ti acyl-CoA delta(11)-desaturase activity|acyl-CoA D11-desaturase activity EC:1.14.19.5 molecular_function owl:Class
GO:0047387 biolink:NamedThing serine-ethanolaminephosphate phosphodiesterase activity Catalysis of the reaction: H(2)O + serine phosphoethanolamine = H(+) + phosphoethanolamine + serine. got7fsn_ti SEP diesterase activity|serine ethanolamine phosphodiester phosphodiesterase activity|serine-phosphoethanolamine ethanolaminephosphohydrolase activity MetaCyc:3.1.4.13-RXN|EC:3.1.4.13|KEGG_REACTION:R02817|RHEA:17113 molecular_function owl:Class
GO:0009992 biolink:NamedThing cellular water homeostasis Any process involved in the maintenance of an internal steady state of water within a cell. got7fsn_ti cellular osmoregulation biological_process owl:Class
GO:0032330 biolink:NamedThing regulation of chondrocyte differentiation Any process that modulates the frequency, rate or extent of chondrocyte differentiation. got7fsn_ti biological_process owl:Class
GO:0061339 biolink:NamedThing establishment or maintenance of monopolar cell polarity Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis. got7fsn_ti dph 2010-09-29T09:10:05Z biological_process owl:Class
GO:0052825 biolink:NamedThing inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate. got7fsn_ti 2011-11-29T09:49:22Z Reactome:R-HSA-1855219 molecular_function owl:Class
GO:0018595 biolink:NamedThing alpha-pinene monooxygenase activity Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol. got7fsn_ti UM-BBD_reactionID:r0716|EC:1.14.13.155|RHEA:32891 molecular_function owl:Class
GO:1990830 biolink:NamedThing cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus. got7fsn_ti cellular response to CDF|cellular response to cholinergic differentiation factor sl 2015-08-20T19:30:38Z biological_process owl:Class
GO:0090716 biolink:NamedThing adaptive immune memory response An immune response directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response. got7fsn_ti tb 2016-11-11T12:32:42Z biological_process owl:Class
GO:0016525 biolink:NamedThing negative regulation of angiogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. got7fsn_ti downregulation of angiogenesis|inhibition of angiogenesis|down regulation of angiogenesis|down-regulation of angiogenesis biological_process owl:Class
GO:2000181 biolink:NamedThing negative regulation of blood vessel morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis. got7fsn_ti dph 2010-10-13T12:46:31Z biological_process owl:Class
GO:0060857 biolink:NamedThing establishment of glial blood-brain barrier Establishment of the glial barrier between the blood and the brain. The glial cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. got7fsn_ti establishment of glial blood/brain barrier|establishment of glial BBB dph 2009-08-12T12:17:51Z biological_process owl:Class
GO:0120319 biolink:NamedThing long-chain fatty acid omega-1 hydroxylase activity Catalysis of the reaction: an (omega-1)-ethyl long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an (omega-1)-hydroxy-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase. got7fsn_ti cytochrome P450 fatty acid omega-1 hydroxylase activity https://github.com/geneontology/go-ontology/issues/21648 krc 2021-06-21T18:31:38Z RHEA:60936 molecular_function owl:Class
GO:0070274 biolink:NamedThing RES complex A protein complex that is required for efficient splicing, and prevents leakage of unspliced pre-mRNAs from the nucleus (named for pre-mRNA REtention and Splicing). In Saccharomyces, the complex consists of Ist3p, Bud13p, and Pml1p. got7fsn_ti pre-mRNA retention and splicing complex cellular_component owl:Class
GO:0032059 biolink:NamedThing bleb A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. got7fsn_ti plasma membrane bleb Wikipedia:Bleb_(cell_biology) cellular_component owl:Class
GO:0102404 biolink:NamedThing linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity Catalysis of the reaction: linalyl 6-O-alpha-L-arabinopyranosyl- beta-D-glucopyranoside + H2O <=> vicianose + linalool. got7fsn_ti EC:3.2.1.149|MetaCyc:RXN-13701 molecular_function owl:Class
GO:0072696 biolink:NamedThing positive regulation of DNA recombination at telomere Any process that activates or increases the frequency, rate or extent of DNA recombination within the telomere. got7fsn_ti positive regulation of telomeric recombination|upregulation of telomeric recombination at telomere|activation of telomeric recombination at telomere|up-regulation of telomeric recombination at telomere|up regulation of telomeric recombination at telomere mah 2012-04-03T11:28:19Z biological_process owl:Class
GO:0072695 biolink:NamedThing regulation of DNA recombination at telomere Any process that modulates the frequency, rate or extent of DNA recombination within the telomere. got7fsn_ti regulation of telomeric recombination mah 2012-04-03T10:31:50Z biological_process owl:Class
GO:1900573 biolink:NamedThing emodin metabolic process The chemical reactions and pathways involving emodin. got7fsn_ti emodin metabolism di 2012-05-15T06:41:44Z biological_process owl:Class
GO:0006769 biolink:NamedThing nicotinamide metabolic process The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms. got7fsn_ti niacin metabolic process|vitamin B3 metabolism|nicotinamide metabolism|niacin metabolism|vitamin B3 metabolic process MetaCyc:PWY-5083 biological_process owl:Class
GO:0075201 biolink:NamedThing penetration hypha formation The assembly by the symbiont of a threadlike, tubular structure, which may contain multiple nuclei and may or may not be divided internally by septa or cross-walls, for the purpose of penetration into its host organism. In the case of an appressorium existing, this term is defined in further details as the process in which the symbiont penetration peg expands to form a hypha which traverses the epidermal cell and emerges into the intercellular space of the mesophyll tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti formation of symbiont penetration hypha for entry into host|symbiont penetration hypha formation for entry into host https://github.com/geneontology/go-ontology/issues/18557 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0036063 biolink:NamedThing acroblast A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle. got7fsn_ti spermatid acroblast See also the fly_anatomy.ontology term 'acroblast ; FBbt:00004947'. bf 2011-12-14T02:29:05Z cellular_component owl:Class
GO:0047653 biolink:NamedThing allantoin racemase activity Catalysis of the reaction: (S)-(+)-allantoin = (R)-(-)-allantoin. got7fsn_ti EC:5.1.99.3|MetaCyc:ALLANTOIN-RACEMASE-RXN|KEGG_REACTION:R03925|RHEA:10804 molecular_function owl:Class
GO:0006139 biolink:NamedThing nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. got7fsn_ti nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|nucleobase, nucleoside and nucleotide metabolic process|cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism|nucleobase, nucleoside, nucleotide and nucleic acid metabolism GO:0055134 biological_process owl:Class
GO:0042270 biolink:NamedThing protection from natural killer cell mediated cytotoxicity The process of protecting a cell from natural killer cell mediated cytotoxicity. got7fsn_ti protection from NK cell mediated cytolysis|protection from natural killer cell mediated cell killing|protection from NK cell mediated cell death|protection from natural killer cell mediated cell death|protection from NK cell mediated cytotoxicity|protection from NK cell mediated cell killing|protection from natural killer cell mediated cytolysis biological_process owl:Class
GO:0045953 biolink:NamedThing negative regulation of natural killer cell mediated cytotoxicity Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity. got7fsn_ti downregulation of natural killer cell mediated cytotoxicity|down regulation of natural killer cell mediated cytotoxicity|inhibition of natural killer cell mediated cytotoxicity|negative regulation of NK cell mediated cell killing|negative regulation of natural killer cell mediated cytolysis|negative regulation of natural killer cell mediated cell death|negative regulation of natural killer cell mediated cell killing|negative regulation of NK cell mediated cytolysis|down-regulation of natural killer cell mediated cytotoxicity|negative regulation of NK cell mediated cytotoxicity|negative regulation of NK cell mediated cell death biological_process owl:Class
GO:0047817 biolink:NamedThing D-arginase activity Catalysis of the reaction: D-arginine + H(2)O = D-ornithine + urea. got7fsn_ti D-arginine amidinohydrolase activity EC:3.5.3.10|RHEA:12901|MetaCyc:D-ARGINASE-RXN|KEGG_REACTION:R02458 molecular_function owl:Class
GO:0075037 biolink:NamedThing positive regulation of appressorium maturation Any process that activates or increases the frequency, rate or extent of symbiont appressorium maturation. got7fsn_ti positive regulation of appressorium maturation on or near host|positive regulation maturation of appressorium on or near host biological_process owl:Class
GO:0019095 biolink:NamedThing pole plasm mitochondrial rRNA localization Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte pole plasm mitochondrial rRNA localization|establishment and maintenance of mitochondrial rRNA localization in pole plasm|pole plasm mitochondrial rRNA localisation GO:0048117 biological_process owl:Class
GO:0036190 biolink:NamedThing indole-2-monooxygenase activity Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O. got7fsn_ti bf 2012-04-19T11:24:48Z RHEA:31899|EC:1.14.14.153|KEGG_REACTION:R07403 molecular_function owl:Class
GO:0046522 biolink:NamedThing S-methyl-5-thioribose kinase activity Catalysis of the reaction: S-methyl-5-thio-D-ribose + ATP = S-methyl-5-thio-alpha-D-ribose 1-phosphate + ADP + 2 H(+). got7fsn_ti ATP:S-methyl-5-thio-D-ribose 1-phosphotransferase activity|ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase activity|5-methylthioribose kinase (phosphorylating)|MTR kinase activity|5-methylthioribose kinase activity|methylthioribose kinase activity EC:2.7.1.100|KEGG_REACTION:R04143|MetaCyc:5-METHYLTHIORIBOSE-KINASE-RXN|RHEA:22312 molecular_function owl:Class
GO:0046103 biolink:NamedThing inosine biosynthetic process The chemical reactions and pathways resulting in the formation of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs. got7fsn_ti inosine anabolism|inosine formation|inosine synthesis|inosine biosynthesis biological_process owl:Class
GO:0033307 biolink:NamedThing phytol salvage A process that generates phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol, from derivatives of it without de novo synthesis. got7fsn_ti phytol salvage pathway MetaCyc:PWY-5107 biological_process owl:Class
GO:0033520 biolink:NamedThing phytol biosynthetic process The chemical reactions and pathways resulting in the formation of phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol. got7fsn_ti phytol formation|phytol anabolism|phytol biosynthesis|phytol synthesis biological_process owl:Class
GO:1900574 biolink:NamedThing emodin catabolic process The chemical reactions and pathways resulting in the breakdown of emodin. got7fsn_ti emodin breakdown|emodin catabolism|emodin degradation di 2012-05-15T06:42:06Z biological_process owl:Class
GO:0031895 biolink:NamedThing V1B vasopressin receptor binding Binding to a V1B vasopressin receptor. got7fsn_ti V1B vasopressin receptor ligand molecular_function owl:Class
GO:0004997 biolink:NamedThing thyrotropin-releasing hormone receptor activity Combining with thyrotropin-releasing hormone to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0039006 biolink:NamedThing pronephric nephron tubule formation The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros. got7fsn_ti pronephros tubule formation|pronephric tubule formation bf 2010-07-02T09:37:27Z biological_process owl:Class
GO:0000469 biolink:NamedThing cleavage involved in rRNA processing Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. got7fsn_ti cleavage during rRNA processing biological_process owl:Class
GO:0004014 biolink:NamedThing adenosylmethionine decarboxylase activity Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2). got7fsn_ti S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]|S-adenosylmethionine decarboxylase activity|adenosyl methionine decarboxylase activity|S-adenosyl-L-methionine carboxy-lyase activity|S-adenosyl-L-methionine decarboxylase activity RHEA:15981|MetaCyc:SAMDECARB-RXN|EC:4.1.1.50|Reactome:R-HSA-351222|KEGG_REACTION:R00178 molecular_function owl:Class
GO:0030594 biolink:NamedThing neurotransmitter receptor activity Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. got7fsn_ti A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity' molecular_function owl:Class
GO:0120286 biolink:NamedThing tryptophan sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of tryptophan. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20181 krc 2020-11-18T01:25:01Z molecular_function owl:Class
GO:0120284 biolink:NamedThing tryptophan binding Binding to 2-amino-3-(1H-indol-3-yl)propanoic acid. got7fsn_ti Trp binding https://github.com/geneontology/go-ontology/issues/20181 krc 2020-11-18T01:04:19Z molecular_function owl:Class
GO:0034363 biolink:NamedThing intermediate-density lipoprotein particle A triglyceride-rich lipoprotein particle that typically contains APOB100, APOE and APOCs and has a density of 1.006-1.019 g/ml and a diameter of between 25-30 nm. IDL particles are found in blood and are formed by the delipidation of very-low-density lipoprotein particles (VLDL). IDL particles are removed from blood by the liver, following binding to the APOE receptor, or are converted to low-density lipoprotein (LDL). got7fsn_ti IDL complex|IDL particle|intermediate-density lipoprotein complex cellular_component owl:Class
GO:0050125 biolink:NamedThing N-benzyloxycarbonylglycine hydrolase activity Catalysis of the reaction: N-benzyloxycarbonylglycine + H(2)O + H(+) = benzyl alcohol + CO(2) + glycine. got7fsn_ti benzyloxycarbonylglycine hydrolase activity|nalpha-carbobenzoxyamino acid amidohydrolase activity|N-benzyloxycarbonylglycine urethanehydrolase activity|nalpha-benzyloxycarbonyl amino acid urethane hydrolase I|nalpha-benzyloxycarbonyl amino acid urethane hydrolase activity EC:3.5.1.58|RHEA:20900|KEGG_REACTION:R02551|MetaCyc:N-BENZYLOXYCARBONYLGLYCINE-HYDROLASE-RXN molecular_function owl:Class
GO:0050220 biolink:NamedThing prostaglandin-E synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin E(2). got7fsn_ti PGH-PGE isomerase activity|PGE2 isomerase activity|endoperoxide isomerase activity|prostaglandin-H2 E-isomerase activity|Prostaglandin-H(2) E-isomerase activity|prostaglandin H-E isomerase activity|prostaglandin R-prostaglandin E isomerase activity|prostaglandin endoperoxide E isomerase activity|(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase activity|PGE isomerase activity|prostaglandin endoperoxide E2 isomerase activity EC:5.3.99.3|MetaCyc:PROSTAGLANDIN-E-SYNTHASE-RXN|Reactome:R-HSA-265295|RHEA:12893|Reactome:R-HSA-2161660|KEGG_REACTION:R02265 molecular_function owl:Class
GO:0035743 biolink:NamedThing CD4-positive, alpha-beta T cell cytokine production Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. bf 2011-03-17T02:21:51Z biological_process owl:Class
GO:0002369 biolink:NamedThing T cell cytokine production Any process that contributes to cytokine production by a T cell. got7fsn_ti T-cell cytokine production|T-lymphocyte cytokine production|T lymphocyte cytokine production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0035026 biolink:NamedThing leading edge cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet. got7fsn_ti biological_process owl:Class
GO:0032402 biolink:NamedThing melanosome transport The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0042197 biolink:NamedThing halogenated hydrocarbon metabolic process The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine. got7fsn_ti halogenated hydrocarbon metabolism biological_process owl:Class
GO:0102392 biolink:NamedThing decanoate-[HmqF protein] ligase activity Catalysis of the reaction: decanoate + ATP(4-) + an HmqF protein <=> AMP(2-) + diphosphoric acid + a decanoyl-HmqF protein. got7fsn_ti MetaCyc:RXN-13623 molecular_function owl:Class
GO:0102052 biolink:NamedThing indole-3-acetyl-proline synthetase activity Catalysis of the reaction: indole-3-acetate + L-proline + ATP(4-) <=> H+ + indole-3-acetyl-proline + AMP(2-) + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10434 molecular_function owl:Class
GO:0098678 biolink:NamedThing viral tropism switching A process by which the range of hosts which a virus can bind and infect is changed. Examples include phages that switch between types of fibers via the action of a virally encoded invertase. got7fsn_ti dos 2017-01-19T13:05:51Z VZ:4498 biological_process owl:Class
GO:0072227 biolink:NamedThing metanephric macula densa development The process whose specific outcome is the progression of the metanephric macula densa over time, from its formation to the mature structure. The metanephric macula densa is an area of specialized cells in the distal tubule of the metanephros that makes contact with the vascular pole of the glomerulus. got7fsn_ti mah 2010-03-18T03:37:26Z biological_process owl:Class
GO:0010342 biolink:NamedThing endosperm cellularization The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization. got7fsn_ti cellularization of endosperm biological_process owl:Class
GO:0007349 biolink:NamedThing cellularization The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development. got7fsn_ti GO:0009796 biological_process owl:Class
GO:1990488 biolink:NamedThing anaerobic cellulose catabolic process The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen. got7fsn_ti anaerobic cellulose degradation tt 2014-09-20T17:43:59Z biological_process owl:Class
GO:0030245 biolink:NamedThing cellulose catabolic process The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. got7fsn_ti cellulose catabolism|cellulose breakdown|cellulose degradation GO:0016179 biological_process owl:Class
GO:0102765 biolink:NamedThing UDP-D-apiose synthase activity Catalysis of the reaction: H+ + UDP-alpha-D-glucuronate = UDP-alpha-D-apiose + carbon dioxide. got7fsn_ti MetaCyc:RXN-7770 molecular_function owl:Class
GO:0002536 biolink:NamedThing respiratory burst involved in inflammatory response A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels. got7fsn_ti production of reactive oxygen species during acute inflammatory response|respiratory burst involved in acute inflammatory response|oxidative burst during acute inflammatory response biological_process owl:Class
GO:0021728 biolink:NamedThing inferior reticular formation development The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:1990210 biolink:NamedThing positive regulation by symbiont of indole acetic acid levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of auxin levels in host|positive regulation by symbiont of IAA levels in host ml 2013-10-09T18:54:11Z biological_process owl:Class
GO:0047754 biolink:NamedThing choline sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + choline = adenosine 3',5'-diphosphate + choline sulfate + H(+). got7fsn_ti choline sulphokinase activity|choline sulphotransferase activity|3'-phosphoadenylyl-sulfate:choline sulfotransferase activity EC:2.8.2.6|MetaCyc:CHOLINE-SULFOTRANSFERASE-RXN|KEGG_REACTION:R01027|RHEA:21984 molecular_function owl:Class
GO:1900683 biolink:NamedThing regulation of fumonisin biosynthetic process Any process that modulates the frequency, rate or extent of fumonisin biosynthetic process. got7fsn_ti regulation of fumonisin anabolism|regulation of fumonisin biosynthesis|regulation of fumonisin synthesis|regulation of fumonisin formation di 2012-05-22T04:29:38Z biological_process owl:Class
GO:0051355 biolink:NamedThing proprioception involved in equilibrioception The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity. got7fsn_ti proprioception during equilibrioception|equilibrioception by proprioception|perception of orientation with respect to gravity by proprioception biological_process owl:Class
GO:0034801 biolink:NamedThing 2,4-dinitrocyclohexanone hydrolase activity Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate. got7fsn_ti UM-BBD_reactionID:r1069 molecular_function owl:Class
GO:0042768 biolink:NamedThing ecdysteroid 2-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 2. got7fsn_ti Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2-deoxyecdysone to ecdysone. It can also catalyze the conversion of 2,22-dideoxyecdysone (ketotriol) to 22-deoxyecdysone. molecular_function owl:Class
GO:0034073 biolink:NamedThing tetrahymanol cyclase activity Catalysis of the reaction: squalene = tetrahymanol. got7fsn_ti molecular_function owl:Class
GO:0034072 biolink:NamedThing squalene cyclase activity Catalysis of the reaction: squalene = triterpene. got7fsn_ti molecular_function owl:Class
GO:0016762 biolink:NamedThing xyloglucan:xyloglucosyl transferase activity Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. got7fsn_ti endo-xyloglucan transferase activity|endoxyloglucan transferase activity|xyloglucan endotransglucosylase activity|xyloglucan:xyloglucan xyloglucanotransferase activity GO:0080039 MetaCyc:2.4.1.207-RXN|EC:2.4.1.207 molecular_function owl:Class
GO:0010284 biolink:NamedThing lariciresinol reductase activity Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+. got7fsn_ti MetaCyc:RXN-8684|MetaCyc:RXN-8679 molecular_function owl:Class
GO:0140486 biolink:NamedThing zinc ion sequestering activity The selective interaction of a protein with a zinc ion to prevent it from interacting with sensitive components of a biological system. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19700 pg 2020-06-29T09:21:42Z molecular_function owl:Class
GO:0052085 biolink:NamedThing suppression by symbiont of host T-cell mediated immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti inhibition by symbiont of host T-cell mediated immune response|down-regulation by symbiont of host T-cell mediated immune response|downregulation by symbiont of host T-cell mediated immune response|down regulation by symbiont of host T-cell mediated immune response|negative regulation by symbiont of host T-cell mediated immune response|negative regulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction GO:0052280 biological_process owl:Class
GO:0033075 biolink:NamedThing isoquinoline alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin. got7fsn_ti isoquinoline alkaloid biosynthesis|isoquinoline alkaloid synthesis|ipecac alkaloid biosynthesis|isoquinoline alkaloid anabolism|isoquinoline alkaloid formation biological_process owl:Class
GO:0003951 biolink:NamedThing NAD+ kinase activity Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+). got7fsn_ti NADK|nicotinamide adenine dinucleotide kinase activity|nicotinamide adenine dinucleotide kinase (phosphorylating)|NAD kinase activity|ATP:NAD+ 2'-phosphotransferase activity|DPN kinase activity EC:2.7.1.23|MetaCyc:NAD-KIN-RXN|Reactome:R-HSA-8955030|KEGG_REACTION:R00104|RHEA:18629|Reactome:R-HSA-197198 molecular_function owl:Class
GO:0102529 biolink:NamedThing apigenin 7-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + apigenin-7-olate <=> S-adenosyl-L-homocysteine + genkwanin. got7fsn_ti MetaCyc:RXN-14661 molecular_function owl:Class
GO:0034942 biolink:NamedThing cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi. got7fsn_ti UM-BBD_reactionID:r0988 molecular_function owl:Class
GO:0004173 biolink:NamedThing ecdysone O-acyltransferase activity Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate. got7fsn_ti palmitoyl-CoA:ecdysone palmitoyltransferase activity|fatty acyl-CoA:ecdysone acyltransferase activity|acyl-CoA:ecdysone acyltransferase activity EC:2.3.1.139|RHEA:15217|KEGG_REACTION:R02375|MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN molecular_function owl:Class
GO:0034206 biolink:NamedThing enhanceosome A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation. got7fsn_ti Wikipedia:Enhanceosome cellular_component owl:Class
GO:0050071 biolink:NamedThing lysyltransferase activity Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol. got7fsn_ti L-lysyl-tRNA:phosphatidylglycerol O3-lysyltransferase activity|L-lysyl-tRNA:phosphatidylglycerol 3-O-lysyltransferase activity EC:2.3.2.3|MetaCyc:LYSYLTRANSFERASE-RXN|RHEA:10668 molecular_function owl:Class
GO:0036438 biolink:NamedThing maintenance of lens transparency A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina. got7fsn_ti maintenance of ocular lens transparency|preservation of lens transparency bf 2013-09-23T13:51:09Z biological_process owl:Class
GO:0036499 biolink:NamedThing PERK-mediated unfolded protein response A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity. got7fsn_ti eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response|PERK signal transduction pathway|endoplasmic reticulum unfolded protein response; PERK signaling|UPR signaling by PERK stress sensor|EIF2AK3-mediated unfolded protein response|PERK branch of UPR|PERK signaling in response to endoplasmic reticulum stress|PKR-like ER kinase signal transduction bf 2015-02-05T13:17:43Z biological_process owl:Class
GO:0008997 biolink:NamedThing ribonuclease R activity Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides. got7fsn_ti EC:3.1.11.- molecular_function owl:Class
GO:0060418 biolink:NamedThing yolk plasma Discrete structures that partition the water-soluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed. got7fsn_ti cellular_component owl:Class
GO:0097225 biolink:NamedThing sperm midpiece The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. got7fsn_ti pr 2012-01-25T01:23:41Z cellular_component owl:Class
GO:0097701 biolink:NamedThing response to pulsatile fluid shear stress Any response to fluid shear stress where the fluid is flowing across a solid surface with periodic variations. For example, the endothelium in straight parts of the artery tree is subjected to pulsatile shear stress with a significant forward direction, which is believed to be an important physiological stimulus enhancing vessel compliance and conferring anti-thrombotic, anti-adhesive, and anti-inflammatory effects. got7fsn_ti pr 2016-01-27T14:13:31Z biological_process owl:Class
GO:0021634 biolink:NamedThing optic nerve formation The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. got7fsn_ti CN II biosynthesis|CN II formation biological_process owl:Class
GO:1900569 biolink:NamedThing chanoclavine-I aldehyde biosynthetic process The chemical reactions and pathways resulting in the formation of chanoclavine-I aldehyde. got7fsn_ti chanoclavine-I aldehyde anabolism|chanoclavine-I aldehyde formation|chanoclavine-I aldehyde synthesis|chanoclavine-I aldehyde biosynthesis di 2012-05-15T06:31:28Z biological_process owl:Class
GO:0034946 biolink:NamedThing 3-isopropylbut-3-enoyl-CoA thioesterase activity Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH. got7fsn_ti UM-BBD_reactionID:r0994 molecular_function owl:Class
GO:0031845 biolink:NamedThing type 5 neuropeptide Y receptor binding Binding to a type 5 neuropeptide Y receptor. got7fsn_ti type 5 neuropeptide Y receptor ligand molecular_function owl:Class
GO:0102201 biolink:NamedThing (+)-2-epi-prezizaene synthase activity Catalysis of the reaction: 2-cis,6-trans-farnesyl diphosphate <=> (+)-2-epi-prezizaene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-12117 molecular_function owl:Class
GO:0044354 biolink:NamedThing macropinosome A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis. got7fsn_ti jl 2011-08-11T10:51:42Z cellular_component owl:Class
GO:0106013 biolink:NamedThing negative regulation of protein localization to cell cortex of cell tip Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the cell cortex of the cell tip. got7fsn_ti hjd 2017-04-28T13:45:38Z biological_process owl:Class
GO:0002105 biolink:NamedThing endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript. got7fsn_ti biological_process owl:Class
GO:0016200 biolink:NamedThing synaptic target attraction The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets. got7fsn_ti biological_process owl:Class
GO:0071186 biolink:NamedThing protocadherin-alpha-v4-protocadherin-gamma-b2 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdhga1-Pcdhgb2 complex mah 2009-11-23T04:21:33Z cellular_component owl:Class
GO:0097363 biolink:NamedThing protein O-GlcNAc transferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine. got7fsn_ti O-GlcNAc transferase|UDP-N-acetyl-D-glucosamine:protein-O-beta-N-acetyl-D-glucosaminyl transferase|O-linked N-acetylglucosaminyltransferase|OGTase pr 2012-07-24T01:46:51Z EC:2.4.1.255|Reactome:R-HSA-9687828 molecular_function owl:Class
GO:0050306 biolink:NamedThing sucrose 1F-fructosyltransferase activity Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose. got7fsn_ti sucrose:sucrose 1'-beta-D-fructosyltransferase activity|sucrose:sucrose 1(F)-beta-D-fructosyltransferase activity|sucrose-sucrose 1-fructosyltransferase activity|SST activity|sucrose:sucrose 1-fructosyltransferase activity|sucrose:sucrose 1F-beta-D-fructosyltransferase activity|sucrose 1(F)-fructosyltransferase activity|sucrose:sucrose fructosyltransferase activity EC:2.4.1.99|RHEA:23312|MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0044647 biolink:NamedThing host-symbiont bicellular tight junction An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane. got7fsn_ti host-parasite tight junction|host-pathogen tight junction jl 2012-07-11T12:56:18Z cellular_component owl:Class
GO:0005923 biolink:NamedThing bicellular tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. got7fsn_ti zonula occludens Wikipedia:Tight_junction|NIF_Subcellular:sao1939999134 cellular_component owl:Class
GO:0140393 biolink:NamedThing norsolorinic acid ketoreductase activity Catalysis of the reaction: (1'S)-averantin + NADP(+) <=> norsolorinic acid + NADPH. got7fsn_ti pg 2019-11-28T14:38:12Z RHEA:35447|EC:1.1.1.349|KEGG_REACTION:R10309|MetaCyc:RXN-9480 molecular_function owl:Class
GO:0045703 biolink:NamedThing ketoreductase activity Catalysis of the reduction of a ketone group to form the corresponding alcohol. got7fsn_ti molecular_function owl:Class
GO:0072228 biolink:NamedThing metanephric prebend segment development The process whose specific outcome is the progression of the metanephric prebend segment over time, from its formation to the mature structure. The metanephric prebend segment is a part of the metanephric descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability. got7fsn_ti mah 2010-03-18T03:37:46Z biological_process owl:Class
GO:0072066 biolink:NamedThing prebend segment development The process whose specific outcome is the progression of the prebend segment over time, from its formation to the mature structure. The prebend segment is a part of the descending thin limb that lies before the bend and exhibits permeabilities characteristic of the ascending limb, especially negligible water permeability. got7fsn_ti mah 2010-01-25T04:14:02Z biological_process owl:Class
GO:0031014 biolink:NamedThing troponin T binding Binding to troponin T, the tropomyosin-binding subunit of the troponin complex. got7fsn_ti molecular_function owl:Class
GO:0015732 biolink:NamedThing prostaglandin transport The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0016937 biolink:NamedThing short-branched-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue. got7fsn_ti EC:1.3.99.- molecular_function owl:Class
GO:0034269 biolink:NamedThing discadenine catabolic process The chemical reactions and pathways resulting in the breakdown of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. got7fsn_ti discadenine breakdown|discadenine degradation|discadenine catabolism biological_process owl:Class
GO:0061185 biolink:NamedThing negative regulation of dermatome development Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. got7fsn_ti dph 2010-07-14T08:43:08Z biological_process owl:Class
GO:0060969 biolink:NamedThing negative regulation of gene silencing Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. got7fsn_ti dph 2009-10-05T03:26:19Z biological_process owl:Class
GO:0010628 biolink:NamedThing positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. got7fsn_ti biological_process owl:Class
GO:0062243 biolink:NamedThing double membrane vesicle viral factory outer membrane The outer of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. got7fsn_ti outer membrane of double membrane vesicle viral factory dph 2020-04-20T20:47:40Z cellular_component owl:Class
GO:0062242 biolink:NamedThing double membrane vesicle viral factory membrane One of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. got7fsn_ti membrane of double membrane vesicle viral factory dph 2020-04-20T20:42:28Z cellular_component owl:Class
GO:0035500 biolink:NamedThing MH2 domain binding Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. got7fsn_ti MAD homology 2 domain binding bf 2010-04-29T03:14:32Z molecular_function owl:Class
GO:0009883 biolink:NamedThing red or far-red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation. got7fsn_ti red/far-red light photoreceptor activity molecular_function owl:Class
GO:0009881 biolink:NamedThing photoreceptor activity The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. got7fsn_ti violet-sensitive opsin|opsin|long-wave-sensitive opsin|short-wave-sensitive opsin|green-sensitive opsin|UV-sensitive opsin|blue-sensitive opsin|red-sensitive opsin molecular_function owl:Class
GO:0047571 biolink:NamedThing 3-oxosteroid 1-dehydrogenase activity Catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor. got7fsn_ti delta1-dehydrogenase activity|3-oxosteroid:acceptor delta1-oxidoreductase activity|3-ketosteroid-1-en-dehydrogenase activity|3-oxosteroid:(2,6-dichlorphenolindophenol) delta1-oxidoreductase activity|1-ene-dehydrogenase activity|3-ketosteroid-delta1-dehydrogenase activity|4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase activity|delta1-steroid reductase activity|3-oxosteroid delta1-dehydrogenase activity|3-oxosteroid:(acceptor) delta1-oxidoreductase activity UM-BBD_enzymeID:e0712|MetaCyc:3-OXOSTEROID-1-DEHYDROGENASE-RXN|RHEA:13329|EC:1.3.99.4 molecular_function owl:Class
GO:0002338 biolink:NamedThing B-1b B cell differentiation The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5. got7fsn_ti B-1b B-cell differentiation|B-1b B lymphocyte differentiation|B-1b B cell development|B-1b B-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0035580 biolink:NamedThing specific granule lumen The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. got7fsn_ti secondary granule lumen bf 2010-10-05T01:33:53Z cellular_component owl:Class
GO:0003785 biolink:NamedThing actin monomer binding Binding to monomeric actin, also known as G-actin. got7fsn_ti G actin binding molecular_function owl:Class
GO:0030057 biolink:NamedThing desmosome A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism. got7fsn_ti spot desmosome|macula adherens Wikipedia:Desmosome cellular_component owl:Class
GO:0038105 biolink:NamedThing sequestering of TGFbeta from receptor via TGFbeta binding Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor. got7fsn_ti extracellular sequestering of TGFbeta|extracellular sequestering of transforming growth factor-beta This term is for annotation of gene products that bind to TGFbeta. For gene products that tether the TGFbeta-containing latency complex to the extracellular matrix, but do not necessarily bind TGF-beta directly, consider instead annotating to 'sequestering of TGFbeta in extracellular matrix ; GO:0035583'. bf 2012-02-22T11:35:58Z biological_process owl:Class
GO:0035581 biolink:NamedThing sequestering of extracellular ligand from receptor The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor. got7fsn_ti extracellular sequestering of receptor ligand|negative regulation of protein bioavailability Preventing a ligand from binding to its cell surface receptor be achieved by binding to the ligand directly, or by binding to members of a ligand-containing complex. bf 2010-10-12T03:12:11Z biological_process owl:Class
GO:0090443 biolink:NamedThing FAR/SIN/STRIPAK complex A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body. got7fsn_ti FAR complex|STRIPAK signalling complex|SIP complex|striatin interacting phosphatase and kinase complex tb 2012-08-23T14:20:39Z cellular_component owl:Class
GO:0089710 biolink:NamedThing endocytic targeting sequence binding Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits. got7fsn_ti molecular_function owl:Class
GO:0102085 biolink:NamedThing N-(4-aminobenzoyl)-L-glutamate synthetase activity Catalysis of the reaction: 4-aminobenzoate + L-glutamate + ATP <=> H+ + p-aminobenzoyl glutamate + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10884 molecular_function owl:Class
GO:0070865 biolink:NamedThing investment cone A cytoskeletal part that consists of a microfilament-rich cone that forms round each nucleus in a spermatogenic cyst and translocates the length of the cyst during sperm individualization. got7fsn_ti F-actin cone mah 2009-08-19T01:29:33Z cellular_component owl:Class
GO:0004925 biolink:NamedThing prolactin receptor activity Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0047293 biolink:NamedThing 4-hydroxybenzoate nonaprenyltransferase activity Catalysis of the reaction: p-hydroxybenzoate + solanesyl pyrophosphate = nonaprenyl-4-hydroxybenzoate + diphosphate. got7fsn_ti solanesyl-diphosphate:4-hydroxybenzoate nonaprenyltransferase activity|nonaprenyl-4-hydroxybenzoate transferase activity|p-hydroxybenzoic acid-polyprenyl transferase activity|4-hydroxybenzoate transferase activity|p-hydroxybenzoate polyprenyltransferase activity|p-hydroxybenzoate dimethylallyltransferase activity|p-hydroxybenzoic-polyprenyl transferase activity MetaCyc:2.5.1.39-RXN|RHEA:17709|EC:2.5.1.39 molecular_function owl:Class
GO:0106126 biolink:NamedThing reservosome membrane The lipid bilayer surrounding a reservosome. got7fsn_ti hjd 2018-05-03T18:01:26Z cellular_component owl:Class
GO:0047304 biolink:NamedThing 2-aminoethylphosphonate-pyruvate transaminase activity Catalysis of the reaction: (2-aminoethyl)phosphonate + pyruvate = L-alanine + phosphonoacetaldehyde. got7fsn_ti (2-aminoethyl)phosphonate:pyruvate aminotransferase activity|(2-aminoethyl)phosphonate aminotransferase activity|2-aminoethylphosphonate aminotransferase activity|(2-aminoethyl)phosphonic acid aminotransferase activity|2-aminoethylphosphonate-pyruvate aminotransferase activity|(2-aminoethyl)phosphonate--pyruvate aminotransferase activity|(2-aminoethyl)phosphonate transaminase activity|2-aminoethylphosphonate--pyruvate aminotransferase activity MetaCyc:2.6.1.37-RXN|RHEA:17021|KEGG_REACTION:R04152|EC:2.6.1.37 molecular_function owl:Class
GO:0047728 biolink:NamedThing carnitine 3-dehydrogenase activity Catalysis of the reaction: carnitine + NAD(+) = 3-dehydrocarnitine + H(+) + NADH. got7fsn_ti carnitine:NAD+ 3-oxidoreductase activity EC:1.1.1.108|MetaCyc:CARNITINE-3-DEHYDROGENASE-RXN|RHEA:19265|KEGG_REACTION:R02395 molecular_function owl:Class
GO:0070083 biolink:NamedThing clathrin-sculpted monoamine transport vesicle membrane The lipid bilayer surrounding a clathrin-sculpted monoamine transport vesicle. got7fsn_ti clathrin sculpted monoamine transport vesicle membrane|clathrin sculpted monoamine constitutive secretory pathway transport vesicle membrane cellular_component owl:Class
GO:0090705 biolink:NamedThing trichome papilla A plant cell papilla that is part of a trichome cell. got7fsn_ti Part of trichome cell (PO:0008030). tb 2016-09-26T12:49:36Z cellular_component owl:Class
GO:0007316 biolink:NamedThing pole plasm RNA localization Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. got7fsn_ti establishment and maintenance of pole plasm RNA localization|pole plasm RNA localisation|oocyte pole plasm RNA localization GO:0048116 biological_process owl:Class
GO:0042609 biolink:NamedThing CD4 receptor binding Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages. got7fsn_ti molecular_function owl:Class
GO:0019715 biolink:NamedThing peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16). got7fsn_ti See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. RESID:AA0027 biological_process owl:Class
GO:0089715 biolink:NamedThing tRNA m6t6A37 methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine. got7fsn_ti This activity is distinct from 'tRNA (adenine-N6-)-methyltransferase activity' (GO:0016430) in that it requires the presence of a threonylcarbamoyl modification. MetaCyc:RXN0-7114 molecular_function owl:Class
GO:0061157 biolink:NamedThing mRNA destabilization Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns. got7fsn_ti dph 2010-06-22T08:42:10Z biological_process owl:Class
GO:0050779 biolink:NamedThing RNA destabilization Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes. got7fsn_ti biological_process owl:Class
GO:0097523 biolink:NamedThing transcription ternary complex A protein-DNA-RNA complex composed of RNA polymerase, template DNA, and an RNA transcript. got7fsn_ti transcription protein-DNA-RNA complex pr 2013-10-18T11:29:57Z cellular_component owl:Class
GO:0061736 biolink:NamedThing engulfment of target by autophagosome The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy. got7fsn_ti dph 2015-09-14T14:10:24Z biological_process owl:Class
GO:0010255 biolink:NamedThing glucose mediated signaling pathway The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes. got7fsn_ti glucose mediated signalling biological_process owl:Class
GO:1990538 biolink:NamedThing xylan O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a xylan= CoA + an acetylated xylan. got7fsn_ti tb 2014-11-18T20:02:51Z molecular_function owl:Class
GO:0060449 biolink:NamedThing bud elongation involved in lung branching The process in which a bud in the lung grows out from the point where it is formed. got7fsn_ti biological_process owl:Class
GO:0047540 biolink:NamedThing 2-enoate reductase activity Catalysis of the reaction: butanoate + NAD+ = 2-butenoate + NADH + H+. got7fsn_ti butanoate:NAD+ delta2-oxidoreductase activity|enoate reductase activity EC:1.3.1.31|MetaCyc:2-ENOATE-REDUCTASE-RXN|RHEA:10200 molecular_function owl:Class
GO:0016149 biolink:NamedThing translation release factor activity, codon specific A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. got7fsn_ti molecular_function owl:Class
GO:0035197 biolink:NamedThing siRNA binding Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. got7fsn_ti small interfering RNA binding molecular_function owl:Class
GO:0061980 biolink:NamedThing regulatory RNA binding Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme. got7fsn_ti dph 2018-02-13T21:46:08Z molecular_function owl:Class
GO:0052838 biolink:NamedThing thiazole metabolic process The chemical reactions and pathways involving thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position. got7fsn_ti thiazole metabolism ai 2011-11-29T03:35:50Z biological_process owl:Class
GO:0102490 biolink:NamedThing 8-oxo-dGTP phosphohydrolase activity Catalysis of the reaction: 8-oxo-dGTP + 2 H2O <=> 8-oxo-dGMP + 2 hydrogenphosphate + 2 H+. got7fsn_ti EC:3.6.1.5|MetaCyc:RXN-14205 molecular_function owl:Class
GO:0050480 biolink:NamedThing imidazolonepropionase activity Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+). got7fsn_ti 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate amidohydrolase activity|imidazolone-5-propionate hydrolase activity|4(5)-imidazolone-5(4)-propionic acid hydrolase activity|imidazolone propionic acid hydrolase activity MetaCyc:IMIDAZOLONEPROPIONASE-RXN|RHEA:23660|KEGG_REACTION:R02288|EC:3.5.2.7 molecular_function owl:Class
GO:0047263 biolink:NamedThing N-acylsphingosine galactosyltransferase activity Catalysis of the reaction: ceramide + UDP-galactose = D-galactosylceramide + UDP. got7fsn_ti UDP-galactose:N-acylsphingosine D-galactosyltransferase activity|UDPgalactose:N-acylsphingosine D-galactosyltransferase activity|uridine diphosphogalactose-acylsphingosine galactosyltransferase activity|UDP galactose-N-acylsphingosine galactosyltransferase activity Reactome:R-HSA-6785933|RHEA:13093|MetaCyc:2.4.1.47-RXN|EC:2.4.1.47 molecular_function owl:Class
GO:0102182 biolink:NamedThing 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity Catalysis of the reaction: 4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol + NAD <=> avenastenone + NADH + carbon dioxide. got7fsn_ti MetaCyc:RXN-11938 molecular_function owl:Class
GO:0043224 biolink:NamedThing nuclear SCF ubiquitin ligase complex A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). got7fsn_ti nuclear Skp1/Cul1/F-box protein complex|nuclear SCF complex|nuclear cullin complex cellular_component owl:Class
GO:0010448 biolink:NamedThing vegetative meristem growth The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia. got7fsn_ti biological_process owl:Class
GO:0047928 biolink:NamedThing gibberellin beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + gibberellin = UDP + gibberellin 2-O-beta-D-glucoside. got7fsn_ti uridine diphosphoglucose-gibberellate 7-glucosyltransferase activity|UDP-glucose:gibberellin 2-O-beta-D-glucosyltransferase activity|UDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity|gibberellin b-glucosyltransferase activity|uridine diphosphoglucose-gibberellate 3-O-glucosyltransferase activity RHEA:20025|MetaCyc:GIBBERELLIN-BETA-GLUCOSYLTRANSFERASE-RXN|EC:2.4.1.176 molecular_function owl:Class
GO:0010305 biolink:NamedThing leaf vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the leaf of vascular plants. got7fsn_ti biological_process owl:Class
GO:0015395 biolink:NamedThing nucleoside transmembrane transporter activity, down a concentration gradient Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient. got7fsn_ti equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity|equilibrative nucleoside transporter activity|equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity GO:0015396|GO:0015397 molecular_function owl:Class
GO:0010790 biolink:NamedThing meiotic sister chromatid cohesion involved in meiosis II The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II. got7fsn_ti biological_process owl:Class
GO:0120324 biolink:NamedThing procyclogenesis The morphological, biochemical and genetic changes that induce the differentiation of bloodstream form trypomastigotes into procyclic trypomastigotes in some of the Trypanosomatidae species such as Trypanosoma brucei. This process occurs inside the midgut of the tsetse fly vectors in T. brucei. got7fsn_ti https://github.com/geneontology/go-ontology/pull/21924 krc 2021-08-03T19:53:17Z biological_process owl:Class
GO:0007250 biolink:NamedThing activation of NF-kappaB-inducing kinase activity The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues. got7fsn_ti positive regulation of NF-kappaB-inducing kinase activity|activation of NIK activity biological_process owl:Class
GO:0007111 biolink:NamedThing meiosis II cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells. got7fsn_ti cytokinesis after meiosis II biological_process owl:Class
GO:0003917 biolink:NamedThing DNA topoisomerase type I (single strand cut, ATP-independent) activity Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. got7fsn_ti type I topoisomerase activity|omega-protein activity|untwisting enzyme activity|topoisomerase|relaxing enzyme activity|nicking-closing enzyme activity|deoxyribonucleate topoisomerase|type I DNA topoisomerase activity|DNA topoisomerase I activity|swivelase activity Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. EC:5.6.2.1|MetaCyc:5.99.1.2-RXN molecular_function owl:Class
GO:1901596 biolink:NamedThing response to reversine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus. got7fsn_ti mah 2012-11-07T17:17:01Z biological_process owl:Class
GO:0102805 biolink:NamedThing codeine O-demethylase activity Catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide. got7fsn_ti RHEA:27413|MetaCyc:RXN-8152|EC:1.14.11.32 molecular_function owl:Class
GO:0102415 biolink:NamedThing quercetin gentiobioside 1,6-glucosyltransferase activity Catalysis of the reaction: quercetin-3-gentiobioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotrioside + UDP + H+. got7fsn_ti MetaCyc:RXN-13798 molecular_function owl:Class
GO:0005166 biolink:NamedThing neurotrophin p75 receptor binding Binding to a neurotrophin p75 receptor. got7fsn_ti neurotrophin p75 receptor ligand molecular_function owl:Class
GO:0016578 biolink:NamedThing histone deubiquitination The modification of histones by removal of ubiquitin groups. got7fsn_ti histone deubiquitylation|histone deubiquitinylation biological_process owl:Class
GO:0060961 biolink:NamedThing phospholipase D inhibitor activity Binds to and stops, prevents or reduces the activity of phospholipase D. got7fsn_ti dph 2009-10-05T02:47:26Z molecular_function owl:Class
GO:0051888 biolink:NamedThing positive regulation of timing of exogen Any process that activates or increases the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. got7fsn_ti stimulation of exogen|positive regulation of exogen|up-regulation of exogen|up regulation of exogen|upregulation of exogen|activation of exogen biological_process owl:Class
GO:0048818 biolink:NamedThing positive regulation of hair follicle maturation Any process that activates or increases the frequency, rate or extent of hair follicle maturation. got7fsn_ti stimulation of hair follicle maturation|up-regulation of hair follicle maturation|upregulation of hair follicle maturation|activation of hair follicle maturation|up regulation of hair follicle maturation biological_process owl:Class
GO:0050951 biolink:NamedThing sensory perception of temperature stimulus The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti sensory perception of thermal stimulus biological_process owl:Class
GO:0018854 biolink:NamedThing 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. got7fsn_ti UM-BBD_reactionID:r0737 molecular_function owl:Class
GO:0098606 biolink:NamedThing selenocystathionine gamma-lyase activity Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid. got7fsn_ti dos 2014-04-16T11:20:00Z Reactome:R-HSA-2408543|RHEA:31151 molecular_function owl:Class
GO:0042256 biolink:NamedThing mature ribosome assembly The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome. got7fsn_ti biological_process owl:Class
GO:0016613 biolink:NamedThing vanadium-iron nitrogenase complex An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer. got7fsn_ti vanadium-iron nitrogenase activity cellular_component owl:Class
GO:0021585 biolink:NamedThing pons structural organization The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum. got7fsn_ti pons structural organisation biological_process owl:Class
GO:0106242 biolink:NamedThing kolavenyl diphosphate synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate. got7fsn_ti hjd 2019-12-19T18:31:00Z RHEA:54676|EC:5.5.1.29 molecular_function owl:Class
GO:0043994 biolink:NamedThing histone acetyltransferase activity (H3-K23 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K23 specific) molecular_function owl:Class
GO:0034295 biolink:NamedThing basidiospore formation The process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium. got7fsn_ti Note that basidiospores and basidia are separate biological structures. The basidium is the structure that bear the basidiospores, but the development of the basidium is a different process than the formation of the basidiospores themselves. For this reason, GO:0034295 basidiospore formation and GO:0075313 basidium development are different terms and are not linked. biological_process owl:Class
GO:0071608 biolink:NamedThing macrophage inflammatory protein-1 alpha production The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti macrophage inflammatory protein production|MIP-1a production|chemokine (C-C motif) ligand 3 production|CCL3 production mah 2010-02-05T04:24:17Z biological_process owl:Class
GO:0046358 biolink:NamedThing butyrate biosynthetic process The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid. got7fsn_ti butyrate anabolism|butanoic acid formation|butanoic acid anabolism|butanoic acid synthesis|butyrate synthesis|butyrate formation|butanoic acid biosynthetic process|butanoic acid biosynthesis|butyrate biosynthesis GO:0043439 biological_process owl:Class
GO:0002438 biolink:NamedThing acute inflammatory response to antigenic stimulus An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. got7fsn_ti biological_process owl:Class
GO:0008703 biolink:NamedThing 5-amino-6-(5-phosphoribosylamino)uracil reductase activity Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH. got7fsn_ti 5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity|5-amino-6-(5'-phosphoribosylamino)uracil reductase activity|aminodioxyphosphoribosylaminopyrimidine reductase activity KEGG_REACTION:R03458|EC:1.1.1.193|RHEA:17845|MetaCyc:RIBOFLAVINSYNREDUC-RXN molecular_function owl:Class
GO:0050926 biolink:NamedThing regulation of positive chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. got7fsn_ti biological_process owl:Class
GO:0014915 biolink:NamedThing regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction. got7fsn_ti biological_process owl:Class
GO:0014880 biolink:NamedThing regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction. got7fsn_ti biological_process owl:Class
GO:0035192 biolink:NamedThing nuclear cortical migration The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo. got7fsn_ti biological_process owl:Class
GO:0035190 biolink:NamedThing syncytial nuclear migration The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex. got7fsn_ti biological_process owl:Class
GO:0019288 biolink:NamedThing isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. got7fsn_ti mevalonate-independent isopentenyl diphosphate biosynthesis|isopentenyl diphosphate synthesis, mevalonate-independent pathway|isopentenyl diphosphate biosynthetic process, MEP pathway|isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway|isopentenyl diphosphate anabolism, mevalonate-independent pathway|isopentenyl diphosphate biosynthetic process, non-mevalonate pathway|isopentenyl diphosphate formation, mevalonate-independent pathway|isopentenyl diphosphate biosynthetic process, mevalonate-independent|isopentenyl diphosphate biosynthetic process via 1-deoxy-D-xylulose 5-phosphate|non-MVA pathway|mevalonate-independent isopentenyl diphosphate biosynthetic process|isopentenyl diphosphate biosynthesis, non-mevalonate pathway|isopentenyl diphosphate biosynthesis, mevalonate-independent MetaCyc:NONMEVIPP-PWY biological_process owl:Class
GO:0048617 biolink:NamedThing embryonic foregut morphogenesis The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase. got7fsn_ti biological_process owl:Class
GO:0034450 biolink:NamedThing ubiquitin-ubiquitin ligase activity Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. got7fsn_ti E4 Reactome:R-HSA-975122|Reactome:R-HSA-937050 molecular_function owl:Class
GO:0098942 biolink:NamedThing retrograde trans-synaptic signaling by trans-synaptic protein complex Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex. got7fsn_ti biological_process owl:Class
GO:0102777 biolink:NamedThing caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA <=> pelargonidin-3,5-diglucoside-5-O-caffeoylglucoside + coenzyme A(4-). got7fsn_ti EC:2.3.1.153|MetaCyc:RXN-7842 molecular_function owl:Class
GO:1990439 biolink:NamedThing MAP kinase serine/threonine phosphatase activity Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase threonine + phosphate and MAP kinase serine phosphate + H2O = MAP kinase serine + phosphate. got7fsn_ti al 2014-07-31T12:21:04Z molecular_function owl:Class
GO:0030158 biolink:NamedThing protein xylosyltransferase activity Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate. got7fsn_ti UDP-D-xylose:core protein beta-D-xylosyltransferase activity|UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity|uridine diphosphoxylose-core protein beta-xylosyltransferase activity|peptide O-xylosyltransferase activity|UDP-D-xylose:protein beta-D-xylosyltransferase activity|UDP-xylose-core protein beta-D-xylosyltransferase activity|UDP-D-xylose:core protein xylosyltransferase activity|uridine diphosphoxylose-protein xylosyltransferase activity RHEA:50192|MetaCyc:2.4.2.26-RXN|Reactome:R-HSA-1878002|EC:2.4.2.26 molecular_function owl:Class
GO:1990386 biolink:NamedThing mitotic cleavage furrow ingression Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed. got7fsn_ti kmv 2014-05-29T20:58:27Z biological_process owl:Class
GO:0047240 biolink:NamedThing lactosylceramide beta-1,3-galactosyltransferase activity Catalysis of the reaction: D-galactosyl-(1->4)-beta-D-glucosyl-R + UDP-D-galactose = D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-R + H(+) + UDP. got7fsn_ti UDPgalactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity|UDP-galactose:D-galactosyl-1,4-beta-D-glucosyl-R beta-1,3-galactosyltransferase activity|uridine diphosphogalactose-lactosylceramide beta1->3-galactosyltransferase activity KEGG_REACTION:R04431|MetaCyc:2.4.1.179-RXN|EC:2.4.1.179|RHEA:18413 molecular_function owl:Class
GO:0038002 biolink:NamedThing endocrine signaling The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other. got7fsn_ti endocrine signalling This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from paracrine signaling. bf 2011-02-25T02:12:19Z biological_process owl:Class
GO:0033382 biolink:NamedThing maintenance of granzyme B location in T cell secretory granule A process in which the protease granyme B is maintained in a secretory granule in a T cell and prevented from moving elsewhere. got7fsn_ti maintenance of granzyme B localization in T lymphocyte secretory granule|maintenance of granzyme B localization in T-lymphocyte secretory granule|maintenance of granzyme B localization in T cell secretory granule|maintenance of granzyme B localization in T-cell secretory granule biological_process owl:Class
GO:0004107 biolink:NamedThing chorismate synthase activity Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. got7fsn_ti 5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)|5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity|5-enolpyruvylshikimate-3-phosphate phospholyase activity MetaCyc:CHORISMATE-SYNTHASE-RXN|EC:4.2.3.5|RHEA:21020|KEGG_REACTION:R01714 molecular_function owl:Class
GO:0050592 biolink:NamedThing 4-hydroxyphenylacetaldehyde oxime monooxygenase activity Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+). got7fsn_ti 4-hydroxybenzeneacetaldehyde oxime monooxygenase activity|cytochrome P450II-dependent monooxygenase activity|(Z)-4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity|CYP71E1 activity|cytochrome P450-II-dependent monooxygenase activity|NADPH-cytochrome P450 reductase (CYP71E1)|4-hydroxyphenylacetaldehyde oxime,NADPH:oxygen oxidoreductase activity EC:1.14.14.37|KEGG_REACTION:R05728|MetaCyc:1.14.13.68-RXN|RHEA:18401 molecular_function owl:Class
GO:1903035 biolink:NamedThing negative regulation of response to wounding Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding. got7fsn_ti negative regulation of physiological response to wounding|inhibition of physiological response to wounding|down-regulation of response to wounding|inhibition of response to wounding|down regulation of physiological response to wounding|downregulation of physiological response to wounding|downregulation of response to wounding|down-regulation of physiological response to wounding|down regulation of response to wounding kmv 2014-05-18T01:28:52Z biological_process owl:Class
GO:0097707 biolink:NamedThing ferroptosis A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes. got7fsn_ti iron-dependent programmed cell death pr 2016-03-03T12:51:18Z biological_process owl:Class
GO:0008215 biolink:NamedThing spermine metabolic process The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication. got7fsn_ti spermine metabolism biological_process owl:Class
GO:0097372 biolink:NamedThing NAD-dependent histone deacetylase activity (H3-K18 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein. got7fsn_ti pr 2012-09-05T13:16:39Z molecular_function owl:Class
GO:0140672 biolink:NamedThing ATAC complex A chromatin remodelling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation. got7fsn_ti Ada Two-A containing complex|KAT2A-containing ATAC complex|Ada-Two-A-containing complex|G-ATAC complex|ADA2A-containing complex|KAT2B-containing ATAC complex|Ada two A containing complex https://github.com/geneontology/go-ontology/issues/21335 pg 2021-06-25T11:05:14Z cellular_component owl:Class
GO:0031860 biolink:NamedThing telomeric 3' overhang formation The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans. got7fsn_ti telomere end processing|telomere 3'-end processing biological_process owl:Class
GO:0050269 biolink:NamedThing coniferyl-aldehyde dehydrogenase activity Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+. got7fsn_ti coniferyl aldehyde:NAD(P)+ oxidoreductase activity MetaCyc:RXN-1241|EC:1.2.1.68 molecular_function owl:Class
GO:0050455 biolink:NamedThing columbamine oxidase activity Catalysis of the reaction: 2 columbamine + O(2) = 2 berberine + 2 H(2)O. got7fsn_ti berberine synthase activity|columbamine:oxygen oxidoreductase (cyclizing) MetaCyc:COLUMBAMINE-OXIDASE-RXN|EC:1.21.3.2|KEGG_REACTION:R00044|RHEA:23564 molecular_function owl:Class
GO:0103103 biolink:NamedThing UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 9-methylthiononylhydroximate <=> 8-methylthiooctyldesulfoglucosinolate + UDP + H+. got7fsn_ti EC:2.4.1.195|MetaCyc:RXNQT-4328 molecular_function owl:Class
GO:0050590 biolink:NamedThing desacetoxyvindoline 4-hydroxylase activity Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2. got7fsn_ti deacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)|desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4beta-hydroxylating)|desacetoxyvindoline-4-hydroxylase activity|D17H activity|desacetoxyvindoline,2-oxoglutarate:oxygen oxidoreductase (4-beta-hydroxylating) activity|desacetyoxyvindoline-17-hydroxylase activity KEGG_REACTION:R05857|EC:1.14.11.20|RHEA:18973|MetaCyc:1.14.11.20-RXN molecular_function owl:Class
GO:0065010 biolink:NamedThing extracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. got7fsn_ti extracellular membrane-enclosed organelle cellular_component owl:Class
GO:0099543 biolink:NamedThing trans-synaptic signaling by soluble gas Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft. got7fsn_ti biological_process owl:Class
GO:0052849 biolink:NamedThing NADPH-dependent curcumin reductase activity Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+. got7fsn_ti ai 2011-12-05T11:03:23Z MetaCyc:RXN0-6676|EC:1.3.1.n3 molecular_function owl:Class
GO:0010151 biolink:NamedThing chloroplast elongation Expansion of the chloroplast that usually precedes division. got7fsn_ti biological_process owl:Class
GO:0046534 biolink:NamedThing positive regulation of photoreceptor cell differentiation Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. got7fsn_ti stimulation of photoreceptor cell differentiation|activation of photoreceptor cell differentiation|up-regulation of photoreceptor cell differentiation|up regulation of photoreceptor differentiation|stimulation of photoreceptor differentiation|up-regulation of photoreceptor differentiation|upregulation of photoreceptor differentiation|positive regulation of photoreceptor differentiation|upregulation of photoreceptor cell differentiation|activation of photoreceptor differentiation|up regulation of photoreceptor cell differentiation GO:0045675 biological_process owl:Class
GO:0047067 biolink:NamedThing hydrogen:quinone oxidoreductase activity Catalysis of the reaction: H(2) + menaquinone = reduced menaquinone. got7fsn_ti membrane-bound hydrogenase activity|quinone-reactive Ni/Fe-hydrogenase activity|hydrogen-ubiquinone oxidoreductase activity|hydrogen:menaquinone oxidoreductase activity KEGG_REACTION:R02965|MetaCyc:1.12.5.1-RXN|EC:1.12.5.1|RHEA:18641 molecular_function owl:Class
GO:0086072 biolink:NamedThing AV node cell-bundle of His cell adhesion involved in cell communication The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. got7fsn_ti atrioventricular node cell-bundle of His cell adhesion involved in cell communication dph 2011-11-22T09:49:59Z biological_process owl:Class
GO:1990319 biolink:NamedThing collagen type XX trimer A collagen homotrimer of alpha1(XX) chains. got7fsn_ti bhm 2014-03-14T16:31:21Z cellular_component owl:Class
GO:0033780 biolink:NamedThing taurochenodeoxycholate 6alpha-hydroxylase activity Catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O. got7fsn_ti taurochenodeoxycholate 6alpha-monooxygenase activity|CYP4A21|taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity|CYP3A4 MetaCyc:RXN-7977|EC:1.14.13.97|RHEA:23644 molecular_function owl:Class
GO:0004043 biolink:NamedThing L-aminoadipate-semialdehyde dehydrogenase activity Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. got7fsn_ti alpha-aminoadipate-semialdehyde dehydrogenase activity|AAR|2-aminoadipate semialdehyde dehydrogenase activity|alpha-aminoadipate reductase activity|aminoadipate semialdehyde dehydrogenase activity|2-aminoadipic semialdehyde dehydrogenase activity|L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity|L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity|L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase|L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity|aminoadipate-semialdehyde dehydrogenase activity Reactome:R-HSA-70941|MetaCyc:1.2.1.31-RXN|EC:1.2.1.31|RHEA:12308 molecular_function owl:Class
GO:0004165 biolink:NamedThing dodecenoyl-CoA delta-isomerase activity Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA. got7fsn_ti delta3,Delta2-enoyl-CoA isomerase activity|dodecenoyl-CoA D-isomerase activity|acetylene-allene isomerase activity|dodecenoyl-CoA (3Z)-(2E)-isomerase activity|dodecenoyl-CoA Delta-isomerase activity|delta3-cis-delta2-trans-enoyl-CoA isomerase|dodecenoyl-CoA isomerase activity|delta(3),Delta(2)-enoyl-CoA isomerase activity|3,2-trans-enoyl-CoA isomerase activity|dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity|delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity GO:0008461 EC:5.3.3.8|MetaCyc:ENOYL-COA-DELTA-ISOM-RXN|RHEA:23716|Reactome:R-HSA-109338|Reactome:R-HSA-6809808 molecular_function owl:Class
GO:0001632 biolink:NamedThing leukotriene B4 receptor activity Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. got7fsn_ti BLT receptor molecular_function owl:Class
GO:0075325 biolink:NamedThing spore dispersal Any process in which an organism disseminates its spores. got7fsn_ti spore dispersal on or near host during symbiotic interaction|passive spore dispersal on or near host|active spore dispersal on or near host during symbiotic interaction|spore dispersal on or near host|active spore dispersal on or near host https://github.com/geneontology/go-ontology/issues/18823 GO:0075326|GO:0075327 biological_process owl:Class
GO:2000293 biolink:NamedThing negative regulation of defecation Any process that stops, prevents or reduces the frequency, rate or extent of defecation. got7fsn_ti bf 2010-12-21T09:23:13Z biological_process owl:Class
GO:0051997 biolink:NamedThing 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity Catalysis of the reaction: 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H imidazole-5-carboxylate + H+ = S-allantoin + CO2. got7fsn_ti OHCU decarboxylase activity|4-(carbamoylamino)-5-hydroxy-2-oxo-2,5-dihydro-1H-imidazole-5-carboxylate decarboxylase activity ai 2010-07-19T10:47:15Z RHEA:26301|MetaCyc:RXN-6201|KEGG_REACTION:R06604 molecular_function owl:Class
GO:0009037 biolink:NamedThing tyrosine-based site-specific recombinase activity Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site. got7fsn_ti site-specific tyrosine recombinase activity|tyrosine recombinase molecular_function owl:Class
GO:0036123 biolink:NamedThing histone H3-K9 dimethylation The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone. got7fsn_ti histone lysine H3 K9 dimethylation|histone H3 K9 dimethylation bf 2012-02-20T03:06:15Z biological_process owl:Class
GO:0048027 biolink:NamedThing mRNA 5'-UTR binding Binding to an mRNA molecule at its 5' untranslated region. got7fsn_ti mRNA 5' UTR binding molecular_function owl:Class
GO:0102090 biolink:NamedThing adrenaline O-methyltransferase activity Catalysis of the reaction: (R)-adrenaline(1+) + S-adenosyl-L-methionine <=> metanephrine + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-10909 molecular_function owl:Class
GO:0044145 biolink:NamedThing modulation of formation of structure involved in a symbiotic process Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. got7fsn_ti modulation of development of symbiont during interaction with host|modulation of development of symbiont involved in interaction with host https://github.com/geneontology/go-ontology/issues/20305 This term partially replaces the obsolete term 'modulation of growth or development of symbiont during interaction with host ; GO:0075338'. See also 'modulation of growth of symbiont during interaction with host ; GO:0044144'. jl 2009-08-06T01:57:38Z biological_process owl:Class
GO:0002039 biolink:NamedThing p53 binding Binding to one of the p53 family of proteins. got7fsn_ti molecular_function owl:Class
GO:1990014 biolink:NamedThing orthogonal array Square array of closely spaced intramembrane particles, 4-6 nm in size, that form supramolecular aggregates found in the plasma membrane of astrocytes, skeletal muscle and epithelial cells. They have been shown to contain aquaporins (water channels). got7fsn_ti orthogonal array of particles|OAP|square array pr 2012-12-13T20:14:15Z NIF_Subcellular:sao1747012216 cellular_component owl:Class
GO:0031573 biolink:NamedThing mitotic intra-S DNA damage checkpoint signaling A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression. got7fsn_ti S-phase checkpoint|signal transduction involved in intra-S DNA damage checkpoint|mitotic intra-S DNA damage checkpoint|intra-S DNA damage checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072428 biological_process owl:Class
GO:0044773 biolink:NamedThing mitotic DNA damage checkpoint signaling A signal transduction process involved in mitotic DNA damage checkpoint. got7fsn_ti mitotic DNA damage checkpoint|signal transduction involved in mitotic DNA damage checkpoint|intracellular signal transduction pathway involved in mitotic DNA damage checkpoint|intracellular signaling pathway involved in mitotic DNA damage checkpoint|intracellular signaling cascade involved in mitotic DNA damage checkpoint https://github.com/geneontology/go-ontology/issues/20935 jl 2013-02-28T15:55:25Z GO:1902402 biological_process owl:Class
GO:0004448 biolink:NamedThing isocitrate dehydrogenase activity Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor. got7fsn_ti isocitric acid dehydrogenase activity|IDP3|oxalosuccinate carboxylase activity|IDP activity|oxalsuccinic decarboxylase activity|IDP1|beta-ketoglutaric-isocitric carboxylase activity|oxalosuccinate decarboxylase activity|IDH activity|IDP2|isocitric dehydrogenase activity MetaCyc:ISOCITDEH-RXN molecular_function owl:Class
GO:0036388 biolink:NamedThing pre-replicative complex assembly The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. got7fsn_ti pre-RC assembly|pre-replication complex assembly bf 2013-06-05T16:29:13Z biological_process owl:Class
GO:0006605 biolink:NamedThing protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. got7fsn_ti nascent polypeptide association|protein sorting along secretory pathway Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing. Wikipedia:Protein_targeting biological_process owl:Class
GO:1901617 biolink:NamedThing organic hydroxy compound biosynthetic process The chemical reactions and pathways resulting in the formation of organic hydroxy compound. got7fsn_ti organic hydroxy compound anabolism|organic hydroxy compound synthesis|organic hydroxy compound formation|organic hydroxy compound biosynthesis pr 2012-11-13T12:54:36Z biological_process owl:Class
GO:0019140 biolink:NamedThing inositol 3-kinase activity Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate. got7fsn_ti inositol-1-kinase (phosphorylating)|ATP:myo-inositol 1-phosphotransferase activity|inositol 1-kinase activity|myo-inositol 3-kinase activity|myoinositol kinase activity|myo-inositol 1-kinase activity RHEA:21804|MetaCyc:MYO-INOSITOL-1-KINASE-RXN|EC:2.7.1.64 molecular_function owl:Class
GO:0044467 biolink:NamedThing glial cell-derived neurotrophic factor production The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons. got7fsn_ti glial cell line-derived neurotrophic factor production|glial cell-derived neurotrophic factor secretion|GDNF production jl 2012-01-17T04:26:05Z biological_process owl:Class
GO:0033939 biolink:NamedThing xylan alpha-1,2-glucuronosidase activity Catalysis of the hydrolysis of alpha-D-(1->2)-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans. got7fsn_ti alpha-(1->2)-glucuronidase activity|1,2-alpha-glucuronidase activity|xylan alpha-D-1,2-(4-O-methyl)glucuronohydrolase activity EC:3.2.1.131|MetaCyc:3.2.1.131-RXN molecular_function owl:Class
GO:0003173 biolink:NamedThing ventriculo bulbo valve development The progression of the ventriculo bulbo valve over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-08T11:16:25Z biological_process owl:Class
GO:0070007 biolink:NamedThing glutamic-type endopeptidase activity Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad. got7fsn_ti molecular_function owl:Class
GO:0071566 biolink:NamedThing UFM1 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier UFM1, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti mah 2010-01-20T04:06:05Z molecular_function owl:Class
GO:0004325 biolink:NamedThing ferrochelatase activity Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX. got7fsn_ti ferro-protoporphyrin chelatase activity|protoheme ferro-lyase (protoporphyrin-forming)|heme synthetase activity|protoheme ferrolyase activity|protoheme ferro-lyase activity|heme synthase activity|iron chelatase activity MetaCyc:PROTOHEMEFERROCHELAT-RXN|EC:4.99.1.1|KEGG_REACTION:R00310|Reactome:R-HSA-189465|RHEA:22584 molecular_function owl:Class
GO:0035200 biolink:NamedThing leg disc anterior/posterior pattern formation The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc. got7fsn_ti biological_process owl:Class
GO:0035223 biolink:NamedThing leg disc pattern formation The process that gives rise to the patterns of cell differentiation in the leg imaginal disc. got7fsn_ti biological_process owl:Class
GO:0047413 biolink:NamedThing N(alpha)-benzyloxycarbonylleucine hydrolase activity Catalysis of the reaction: N-benzyloxycarbonyl-L-leucine + H(2)O + H(+) = L-leucine + benzyl alcohol + CO(2). got7fsn_ti benzyloxycarbonylleucine hydrolase activity|alpha-N-benzyloxycarbonyl-L-leucine urethanehydrolase activity|nalpha-benzyloxycarbonylleucine hydrolase activity|nalpha-benzyloxycarbonyl-L-leucine urethanehydrolase activity|nalpha-benzyloxycarbonyl amino acid urethane hydrolase IV KEGG_REACTION:R02552|EC:3.5.1.64|RHEA:18901|MetaCyc:3.5.1.64-RXN molecular_function owl:Class
GO:0002107 biolink:NamedThing generation of mature 3'-end of 5S rRNA generated by RNA polymerase III The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end. got7fsn_ti biological_process owl:Class
GO:0039707 biolink:NamedThing pore formation by virus in membrane of host cell The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism. got7fsn_ti pore formation in membrane of host cell by virus|viroporin bf 2013-11-25T15:33:33Z biological_process owl:Class
GO:0061766 biolink:NamedThing positive regulation of lung blood pressure The process that increases the force with which blood travels through the lungs. got7fsn_ti positive regulation of pulmonary blood pressure dph 2016-04-27T11:54:34Z biological_process owl:Class
GO:0047432 biolink:NamedThing 2,2-dialkylglycine decarboxylase (pyruvate) activity Catalysis of the reaction: 2,2-dialkylglycine + H(+) + pyruvate = L-alanine + CO(2) + dialkyl ketone. got7fsn_ti dialkyl amino acid (pyruvate) decarboxylase activity|L-alanine-alpha-ketobutyrate aminotransferase activity|alpha-dialkyl amino acid transaminase activity|2,2-dialkylglycine carboxy-lyase (amino-transferring)|dialkylamino-acid decarboxylase (pyruvate)|2,2-dialkylglycine carboxy-lyase (amino-transferring; L-alanine-forming)|2,2-dialkyl-2-amino acid-pyruvate aminotransferase activity EC:4.1.1.64|KEGG_REACTION:R03854|MetaCyc:4.1.1.64-RXN|RHEA:16073 molecular_function owl:Class
GO:0061289 biolink:NamedThing Wnt signaling pathway involved in kidney development The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the kidney over time. got7fsn_ti Wnt receptor signaling pathway involved in kidney development|Wnt receptor signalling pathway involved in kidney development|Wnt-activated signaling pathway involved in kidney development dph 2010-09-03T12:04:50Z biological_process owl:Class
GO:0060995 biolink:NamedThing cell-cell signaling involved in kidney development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ. got7fsn_ti cell-cell signalling involved in kidney development dph 2010-01-19T08:33:40Z biological_process owl:Class
GO:0102419 biolink:NamedThing sn-2-glycerol-3-phosphate omega-OH-C22:0-CoA acyl transferase activity Catalysis of the reaction: omega-hydroxy-C22:0-CoA + sn-glycerol 3-phosphate = coenzyme A + 2-omega-hydroxy-C22:0-LPA. got7fsn_ti MetaCyc:RXN-13803|RHEA:33559|EC:2.3.1.198 molecular_function owl:Class
GO:0048743 biolink:NamedThing positive regulation of skeletal muscle fiber development Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. got7fsn_ti positive regulation of skeletal myofiber development|activation of skeletal muscle fiber development|up regulation of skeletal muscle fiber development|positive regulation of skeletal myofibre development|stimulation of skeletal muscle fiber development|positive regulation of skeletal muscle fibre development|upregulation of skeletal muscle fiber development|up-regulation of skeletal muscle fiber development biological_process owl:Class
GO:0004066 biolink:NamedThing asparagine synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. got7fsn_ti asparagine synthase (glutamine-hydrolysing)|asparagine synthetase B activity|asparagine synthetase (glutamine-hydrolysing)|AS|glutamine-dependent asparagine synthetase activity|asparagine synthetase (glutamine-hydrolyzing) activity|L-aspartate:L-glutamine amido-ligase (AMP-forming)|AS-B activity EC:6.3.5.4|Reactome:R-HSA-70599|MetaCyc:ASNSYNB-RXN|RHEA:12228 molecular_function owl:Class
GO:0099501 biolink:NamedThing exocytic vesicle membrane The lipid bilayer surrounding an exocytic vesicle. got7fsn_ti secretory vesicle membrane cellular_component owl:Class
GO:0019688 biolink:NamedThing purine deoxyribonucleoside interconversion The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside. got7fsn_ti biological_process owl:Class
GO:0046122 biolink:NamedThing purine deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). got7fsn_ti purine deoxyribonucleoside metabolism biological_process owl:Class
GO:0005601 biolink:NamedThing classical-complement-pathway C3/C5 convertase complex A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone. got7fsn_ti cellular_component owl:Class
GO:0060711 biolink:NamedThing labyrinthine layer development The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state. got7fsn_ti dph 2009-06-09T03:27:43Z biological_process owl:Class
GO:0032136 biolink:NamedThing adenine/cytosine mispair binding Binding to a double-stranded DNA region containing an A/C mispair. got7fsn_ti C/A mispair binding|cytosine/adenine mispair binding|A/C mispair binding molecular_function owl:Class
GO:0032529 biolink:NamedThing follicle cell microvillus organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments. got7fsn_ti follicle cell microvillus organisation|follicle cell microvillus organization and biogenesis biological_process owl:Class
GO:0035680 biolink:NamedThing posterior lateral line neuromast hair cell morphogenesis The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. got7fsn_ti bf 2011-02-14T11:08:14Z biological_process owl:Class
GO:0097134 biolink:NamedThing cyclin E1-CDK2 complex A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:58:42Z cellular_component owl:Class
GO:0060435 biolink:NamedThing bronchiole development The biological process whose specific outcome is the progression of a bronchiole from an initial condition to its mature state. This process begins with the formation of the bronchiole and ends with the mature structure. A bronchiole is the first airway branch that no longer contains cartilage; it is a branch of the bronchi. got7fsn_ti biological_process owl:Class
GO:0016724 biolink:NamedThing oxidoreductase activity, acting on metal ions, oxygen as acceptor Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor. got7fsn_ti oxidoreductase activity, oxidizing metal ions, oxygen as acceptor https://github.com/geneontology/go-ontology/issues/20682 EC:1.16.3.- molecular_function owl:Class
GO:0033207 biolink:NamedThing beta-1,4-N-acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage. got7fsn_ti beta-1,4-GalNAc transferase activity molecular_function owl:Class
GO:0090701 biolink:NamedThing specification of plant organ identity The regionalization process in which the identity of a plant organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti tb 2016-08-29T15:09:18Z biological_process owl:Class
GO:2001157 biolink:NamedThing negative regulation of proline catabolic process to glutamate Any process that stops, prevents or reduces the frequency, rate or extent of proline catabolic process to glutamate. got7fsn_ti negative regulation of proline breakdown to glutamate|negative regulation of proline oxidation|negative regulation of proline degradation to glutamate mcc 2011-10-25T08:54:43Z biological_process owl:Class
GO:0010335 biolink:NamedThing response to non-ionic osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment. got7fsn_ti biological_process owl:Class
GO:0047256 biolink:NamedThing lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP. got7fsn_ti LA2 synthase activity|uridine diphosphoacetylglucosamine-lactosylceramide beta-acetylglucosaminyltransferase activity|beta1->3-N-acetylglucosaminyltransferase activity|lactosylceramide beta-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity EC:2.4.1.206|RHEA:13905|MetaCyc:2.4.1.206-RXN molecular_function owl:Class
GO:0103056 biolink:NamedThing gibberellin A53, 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A53 + O2 + 2-oxoglutarate <=> gibberellin A44 diacid + carbon dioxide + succinate. got7fsn_ti RHEA:60800|MetaCyc:RXN1F-167 molecular_function owl:Class
GO:0022019 biolink:NamedThing dorsal lateral ganglionic eminence cell proliferation The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population. got7fsn_ti biological_process owl:Class
GO:0001787 biolink:NamedThing natural killer cell proliferation The expansion of a natural killer cell population by cell division. got7fsn_ti NK cell proliferation biological_process owl:Class
GO:0030101 biolink:NamedThing natural killer cell activation The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti NK cell activation biological_process owl:Class
GO:0090223 biolink:NamedThing chromatin-templated microtubule nucleation The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin. got7fsn_ti tb 2010-01-13T10:53:35Z biological_process owl:Class
GO:0030079 biolink:NamedThing light-harvesting complex, peripheral complex Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center. got7fsn_ti cellular_component owl:Class
GO:1990111 biolink:NamedThing spermatoproteasome complex A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity. got7fsn_ti sp 2013-05-31T11:56:52Z cellular_component owl:Class
GO:0005750 biolink:NamedThing mitochondrial respiratory chain complex III A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. got7fsn_ti mitochondrial electron transport complex III|mitochondrial coenzyme Q-cytochrome c oxidoreductase complex|mitochondrial ubiquinol-cytochrome c oxidoreductase complex|mitochondrial cytochrome bc(1) complex|mitochondrial complex III|mitochondrial cytochrome bc1 complex|mitochondrial coenzyme Q-cytochrome c reductase complex|mitochondrial ubiquinol-cytochrome-c reductase complex GO:0015008 cellular_component owl:Class
GO:0005516 biolink:NamedThing calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. got7fsn_ti molecular_function owl:Class
GO:0033899 biolink:NamedThing ribonuclease U2 activity Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Ap or Gp with 2',3'-cyclic phosphate intermediates. got7fsn_ti pleospora RNase activity|purine-specific RNase activity|purine-specific ribonuclease activity|trichoderma koningi RNase III activity|RNase U2 activity|ribonuclease U2 activity|ribonuclease (purine) activity|purine specific endoribonuclease activity MetaCyc:3.1.27.4-RXN|EC:4.6.1.20 molecular_function owl:Class
GO:0000981 biolink:NamedThing DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. got7fsn_ti RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding|metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding|RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity|RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity|RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor|RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding|sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity|sequence-specific distal enhancer binding RNA polymerase II transcription factor activity https://github.com/geneontology/go-ontology/issues/16131|https://github.com/geneontology/go-ontology/issues/15530|https://github.com/geneontology/go-ontology/issues/16152 For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. krc 2010-08-10T02:37:21Z GO:0001202|GO:0001201|GO:0003705|GO:0000982|GO:0001200|GO:0001203|GO:0001133 molecular_function owl:Class
GO:0008678 biolink:NamedThing 2-deoxy-D-gluconate 3-dehydrogenase activity Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+. got7fsn_ti 2-keto-3-deoxygluconate oxidoreductase activity|2-deoxygluconate dehydrogenase activity|2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity MetaCyc:KDUD-RXN|RHEA:12160|EC:1.1.1.125 molecular_function owl:Class
GO:0052868 biolink:NamedThing protein-lysine lysyltransferase activity Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine. got7fsn_ti ai 2012-01-11T03:05:27Z molecular_function owl:Class
GO:0006006 biolink:NamedThing glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. got7fsn_ti glucose metabolism|cellular glucose metabolic process biological_process owl:Class
GO:0019318 biolink:NamedThing hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. got7fsn_ti hexose metabolism biological_process owl:Class
GO:0004313 biolink:NamedThing [acyl-carrier-protein] S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]. got7fsn_ti [acyl-carrier protein] S-acetyltransferase activity|ACP acetyltransferase activity|acetyl coenzyme A-acyl-carrier-protein transacylase activity|acyl-carrier-protein acetyltransferase activity|acyl-carrier-proteinacetyltransferase activity|acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity|ACAT activity|ACP S-acetyltransferase activity|ACPacetyltransferase activity|acyl-carrier-protein S-acetyltransferase activity MetaCyc:ACP-S-ACETYLTRANSFER-RXN|EC:2.3.1.38|RHEA:41788 molecular_function owl:Class
GO:0044868 biolink:NamedThing modulation by host of viral molecular function A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected. got7fsn_ti jl 2014-09-18T13:34:27Z biological_process owl:Class
GO:0080011 biolink:NamedThing baruol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = baruol. Baruol is also known as D:B-Friedo-Baccharan-5,21-dien-3-ol. got7fsn_ti RHEA:31987|MetaCyc:RXN-9685|EC:5.4.99.57 molecular_function owl:Class
GO:0039524 biolink:NamedThing suppression by virus of host mRNA processing Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. got7fsn_ti inhibition of host mRNA processing by virus|inhibition by virus of host mRNA processing|negative regulation by virus of host mRNA processing|inhibition of host pre-mRNA processing by virus bf 2011-06-22T04:51:55Z VZ:903 biological_process owl:Class
GO:0008813 biolink:NamedThing chorismate lyase activity Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate. got7fsn_ti 4-hydroxybenzoate synthetase activity|chorismate pyruvate lyase activity|CL|chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity|CPL|UbiC RHEA:16505|MetaCyc:CHORPYRLY-RXN|KEGG_REACTION:R01302|EC:4.1.3.40 molecular_function owl:Class
GO:0097675 biolink:NamedThing SCF-Hrt3/Pof7 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe). got7fsn_ti pr 2014-10-06T10:31:14Z cellular_component owl:Class
GO:1990820 biolink:NamedThing response to mitotic DNA integrity checkpoint signaling A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling. got7fsn_ti response to signal involved in mitotic DNA integrity checkpoint mah 2015-08-14T10:25:46Z biological_process owl:Class
GO:0052657 biolink:NamedThing guanine phosphoribosyltransferase activity Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. got7fsn_ti purine-6-thiol phosphoribosyltransferase activity|guanine-hypoxanthine phosphoribosyltransferase activity|hypoxanthine-guanine phosphoribosyltransferase activity|guanosine phosphoribosyltransferase activity|Transphosphoribosidase activity|6-hydroxypurine phosphoribosyltransferase activity|guanylic pyrophosphorylase activity|GMP pyrophosphorylase activity|guanosine 5'-phosphate pyrophosphorylase activity|guanylate pyrophosphorylase activity|GPRT|6-mercaptopurine phosphoribosyltransferase activity EC:2.4.2.8|KEGG_REACTION:R01229|MetaCyc:GUANPRIBOSYLTRAN-RXN|RHEA:25424 molecular_function owl:Class
GO:0050347 biolink:NamedThing trans-octaprenyltranstransferase activity Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate. got7fsn_ti solanesyl pyrophosphate synthetase activity|all-trans-nonaprenyl-diphosphate synthase activity|terpenyl pyrophosphate synthetase activity|terpenoidallyltransferase activity|solanesyl-diphosphate synthase activity|(E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase activity|polyprenylpyrophosphate synthetase activity|SPP synthase activity|nonaprenyl pyrophosphate synthetase activity|trans-prenyltransferase activity RHEA:11324|KEGG_REACTION:R07267 molecular_function owl:Class
GO:0002439 biolink:NamedThing chronic inflammatory response to antigenic stimulus A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual. got7fsn_ti biological_process owl:Class
GO:0018003 biolink:NamedThing peptidyl-lysine N6-acetylation The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine. got7fsn_ti See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'. RESID:AA0055 biological_process owl:Class
GO:0071618 biolink:NamedThing lysophosphatidylethanolamine acyltransferase activity Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidylethanolamine. got7fsn_ti mah 2010-02-08T04:59:07Z molecular_function owl:Class
GO:0001147 biolink:NamedThing transcription termination site sequence-specific DNA binding Binding to a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon. got7fsn_ti transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding|transcription termination site DNA binding|bacterial-type RNA polymerase termination site sequence-specific DNA binding|mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity|mitochondrial RNA polymerase termination site sequence-specific DNA binding Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a DNA specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation. krc 2011-01-27T02:42:23Z GO:0001148|GO:0001146|GO:0001160|GO:0001145 molecular_function owl:Class
GO:0102918 biolink:NamedThing (R)-reticuline 7-O-methyltransferase activity Catalysis of the reaction: (R)-reticulinium(1+) + S-adenosyl-L-methionine <=> (R)-laudanine(1+) + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-8701|EC:2.1.1.291|RHEA:38907 molecular_function owl:Class
GO:0070764 biolink:NamedThing gamma-secretase-Delta1 complex A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex. got7fsn_ti mah 2009-06-29T01:11:51Z cellular_component owl:Class
GO:0036051 biolink:NamedThing protein localization to trailing edge A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement. got7fsn_ti protein localisation to trailing edge bf 2011-12-12T10:44:04Z biological_process owl:Class
GO:0018847 biolink:NamedThing alpha-pinene lyase activity Catalysis of the reaction: alpha-pinene = limonene. got7fsn_ti EC:5.5.1.-|UM-BBD_reactionID:r0712 molecular_function owl:Class
GO:0034454 biolink:NamedThing microtubule anchoring at centrosome Any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome. got7fsn_ti biological_process owl:Class
GO:0072393 biolink:NamedThing microtubule anchoring at microtubule organizing center Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center. got7fsn_ti microtubule anchoring at microtubule organising centre|microtubule anchoring at MTOC mah 2010-12-07T11:54:35Z biological_process owl:Class
GO:0035260 biolink:NamedThing internal genitalia morphogenesis The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals. got7fsn_ti biological_process owl:Class
GO:0030735 biolink:NamedThing carnosine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+). got7fsn_ti S-adenosyl-L-methionine:carnosine N-methyltransferase activity EC:2.1.1.22|KEGG_REACTION:R02144|MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN|RHEA:14205|Reactome:R-HSA-8876789 molecular_function owl:Class
GO:0030770 biolink:NamedThing demethylmacrocin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin. got7fsn_ti demethylmacrocin methyltransferase activity|S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity EC:2.1.1.102|RHEA:17573|KEGG_REACTION:R02859|MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0090582 biolink:NamedThing protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0050504 biolink:NamedThing mannosyl-3-phosphoglycerate synthase activity Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+). got7fsn_ti MPG synthase activity|GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase activity RHEA:13537|EC:2.4.1.217|MetaCyc:2.4.1.217-RXN|KEGG_REACTION:R05768 molecular_function owl:Class
GO:1990145 biolink:NamedThing maintenance of translational fidelity Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template. got7fsn_ti hjd 2013-07-24T19:30:09Z biological_process owl:Class
GO:0018754 biolink:NamedThing ammelide aminohydrolase activity Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3. got7fsn_ti MetaCyc:RXN-8017 molecular_function owl:Class
GO:0039505 biolink:NamedThing suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex. got7fsn_ti inhibition of host MHC class II molecule presentation by virus bf 2011-06-02T02:34:51Z VZ:820 biological_process owl:Class
GO:0052762 biolink:NamedThing gellan lyase activity Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha). got7fsn_ti ai 2011-09-29T03:19:25Z MetaCyc:RXN-12269|EC:4.2.2.25 molecular_function owl:Class
GO:0019551 biolink:NamedThing glutamate catabolic process to 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate. got7fsn_ti glutamate catabolism to 2-ketoglutarate|glutamate catabolic process to 2-ketoglutarate|glutamate breakdown to 2-oxoglutarate|glutamate catabolism to alpha-ketoglutarate|glutamate catabolism to alpha-oxoglutarate|glutamate degradation to 2-oxoglutarate|glutamate catabolic process to alpha-ketoglutarate|glutamate catabolic process to alpha-oxoglutarate MetaCyc:PWY-5766|MetaCyc:GLUTAMATE-DEG1-PWY biological_process owl:Class
GO:0006106 biolink:NamedThing fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. got7fsn_ti fumarate metabolism biological_process owl:Class
GO:0046979 biolink:NamedThing TAP2 binding Binding to the TAP2 subunit of TAP (transporter associated with antigen processing) protein. got7fsn_ti molecular_function owl:Class
GO:0046977 biolink:NamedThing TAP binding Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. got7fsn_ti molecular_function owl:Class
GO:0047005 biolink:NamedThing 16-alpha-hydroxysteroid dehydrogenase activity Catalysis of the reaction: NADP+ + 16-alpha-hydroxysteroid = NADPH + H+ + 16-oxosteroid. got7fsn_ti 16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase activity|16alpha-hydroxysteroid dehydrogenase activity|16alpha-hydroxy steroid dehydrogenase activity MetaCyc:1.1.1.147-RXN|EC:1.1.1.147 molecular_function owl:Class
GO:0075198 biolink:NamedThing modulation of symbiont haustorium neck formation for entry into host Any process that modulates the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0000253 biolink:NamedThing 3-keto sterol reductase activity Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+). got7fsn_ti 3-keto-steroid reductase activity|3beta-hydroxy-steroid:NADP+ 3-oxidoreductase|3-KSR activity Note that zymosterol is cholesta-8,24-dien-3-ol. GO:0050576 Reactome:R-HSA-194632|MetaCyc:RXN3O-4110|MetaCyc:RXN66-319|MetaCyc:RXN66-24|Reactome:R-HSA-194689|MetaCyc:RXN66-19|MetaCyc:RXN66-314|MetaCyc:1.1.1.270-RXN|RHEA:18409|EC:1.1.1.270 molecular_function owl:Class
GO:0031569 biolink:NamedThing mitotic G2 cell size control checkpoint signaling A signal transduction process that contributes to a cell size control checkpoint prior to the G2/M transition of mitosis. got7fsn_ti signal transduction involved in mitotic cell cycle G2/M transition size control checkpoint|G2/M transition size control checkpoint|signal transduction involved in G2 cell size control checkpoint|G2 cell size control checkpoint|signal transduction involved in G2/M transition size control checkpoint|mitotic cell cycle G2/M transition size control checkpoint|mitotic G2 cell size control checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072453 biological_process owl:Class
GO:0033326 biolink:NamedThing cerebrospinal fluid secretion The regulated release of cerebrospinal fluid (CSF) from the choroid plexus of the lateral, third and fourth ventricles. The cerebrospinal fluid is a clear liquid that located within the ventricles, spinal canal, and subarachnoid spaces. got7fsn_ti CSF secretion biological_process owl:Class
GO:0045518 biolink:NamedThing interleukin-22 receptor binding Binding to an interleukin-22 receptor. got7fsn_ti interleukin-22 receptor ligand|IL-22 molecular_function owl:Class
GO:1990503 biolink:NamedThing dendritic lamellar body A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions. got7fsn_ti DLB sl 2014-09-30T20:47:28Z cellular_component owl:Class
GO:0018038 biolink:NamedThing C-terminal peptidyl-cysteine amidation The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0085 biological_process owl:Class
GO:0045159 biolink:NamedThing myosin II binding Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. got7fsn_ti molecular_function owl:Class
GO:0061948 biolink:NamedThing premature acrosome loss The discharge, by sperm, of a single, anterior secretory granule before the sperm reaches to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents. got7fsn_ti spontaneous acrosome loss If the release of the acrosome content when the sperm reaches to the zona pellucida, consider using acrosome reaction. dph 2017-10-25T17:46:55Z biological_process owl:Class
GO:0010130 biolink:NamedThing anaerobic ethylbenzene catabolic process The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen. got7fsn_ti anaerobic ethylbenzene degradation|anaerobic ethylbenzene breakdown|anaerobic ethylbenzene catabolism MetaCyc:PWY-481 biological_process owl:Class
GO:0018913 biolink:NamedThing anaerobic ethylbenzene metabolic process The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen. got7fsn_ti anaerobic ethylbenzene metabolism UM-BBD_pathwayID:ethb biological_process owl:Class
GO:0103082 biolink:NamedThing 2-(4'-methylthio)butylmalate synthase activity Catalysis of the reaction: 2-oxo-6-methylthiohexanoate + acetyl-CoA + H2O <=> H+ + 2-(4'-methylthio)butylmalate + coenzyme A. got7fsn_ti MetaCyc:RXNQT-4166 molecular_function owl:Class
GO:0018230 biolink:NamedThing peptidyl-L-cysteine S-palmitoylation The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine. got7fsn_ti peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine|peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine|peptidyl-cysteine S-palmitoylation Palmitoylation of a non-terminal cysteine residue always occurs on a sulfur (S) atom. RESID:AA0106 biological_process owl:Class
GO:0018231 biolink:NamedThing peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids. got7fsn_ti peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine|peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine|peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine RESID:AA0107 biological_process owl:Class
GO:0098969 biolink:NamedThing neurotransmitter receptor transport to postsynaptic membrane The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles. got7fsn_ti biological_process owl:Class
GO:0050148 biolink:NamedThing nucleotide diphosphokinase activity Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate. got7fsn_ti ATP nucleotide 3'-pyrophosphokinase activity|nucleotide pyrophosphokinase activity|ATP:nucleotide pyrophosphotransferase activity|nucleotide 3'-pyrophosphokinase activity|ATP:nucleoside-5'-phosphate diphosphotransferase activity RHEA:12713|MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN|EC:2.7.6.4 molecular_function owl:Class
GO:0046938 biolink:NamedThing phytochelatin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. got7fsn_ti phytochelatin biosynthesis|cadystin biosynthetic process|phytochelatin synthesis|phytochelatin formation|phytochelatin anabolism biological_process owl:Class
GO:0033991 biolink:NamedThing aldos-2-ulose dehydratase activity Catalysis of the reactions: 1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H2O; (1a) 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O and (1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one. got7fsn_ti AUDH|pyranosone dehydratase activity|1,5-anhydro-D-fructose dehydratase (microthecin-forming) activity|1,5-anhydro-D-fructose hydro-lyase (microthecin-forming) activity EC:4.2.1.110|RHEA:12100|MetaCyc:4.2.1.110-RXN molecular_function owl:Class
GO:0033957 biolink:NamedThing lambda-carrageenase activity Catalysis of the endohydrolysis of beta-1,4-linkages in the backbone of lambda-carrageenan, resulting in the tetrasaccharide alpha-D-Galp2,6S2-(1->3)-beta-D-Galp2S-(1->4)-alpha-D-Galp2,6S2-(1->3)-D-Galp2S. got7fsn_ti endo-beta-1,4-carrageenose 2,6,2'-trisulfate-hydrolase activity MetaCyc:3.2.1.162-RXN|EC:3.2.1.162 molecular_function owl:Class
GO:0099562 biolink:NamedThing maintenance of postsynaptic density structure A process which maintains the organization and the arrangement of proteins in the presynaptic density. got7fsn_ti biological_process owl:Class
GO:0046374 biolink:NamedThing teichoic acid metabolic process The chemical reactions and pathways involving teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. got7fsn_ti teichoic acid metabolism biological_process owl:Class
GO:0044495 biolink:NamedThing modulation of blood pressure in other organism A process by which one organism modulates the force with which blood travels through the circulatory system of another organism. got7fsn_ti regulation of blood pressure in other organism jl 2012-02-01T02:10:15Z biological_process owl:Class
GO:0042077 biolink:NamedThing protein phosphate-linked glycosylation via serine The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues. got7fsn_ti protein amino acid phosphate-linked glycosylation via serine biological_process owl:Class
GO:0042076 biolink:NamedThing protein phosphate-linked glycosylation The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues. got7fsn_ti phosphoglycosylation|protein amino acid phosphate-linked glycosylation biological_process owl:Class
GO:0051676 biolink:NamedThing pullulan metabolic process The chemical reactions and pathways involving pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages. got7fsn_ti pullulan metabolism biological_process owl:Class
GO:0061301 biolink:NamedThing cerebellum vasculature morphogenesis The process in which the vasculature of the cerebellum is generated and organized. got7fsn_ti dph 2010-09-06T03:38:05Z biological_process owl:Class
GO:0008693 biolink:NamedThing 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O. got7fsn_ti D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity|beta-hydroxydecanoyl thiol ester dehydrase activity|beta-hydroxyacyl-acyl carrier protein dehydratase activity|3-hydroxydecanoyl-acyl carrier protein dehydratase activity|3-hydroxydecanoyl-acyl carrier protein dehydrase activity|beta-hydroxyacyl-ACP dehydrase activity|HDDase activity|3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity|(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity|3-hydroxydecanoyl-ACP dehydratase activity|D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity|3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity|FabA|beta-hydroxydecanoate dehydrase activity|beta-hydroxydecanoyl thioester dehydrase activity EC:4.2.1.59|RHEA:41860 molecular_function owl:Class
GO:1903037 biolink:NamedThing regulation of leukocyte cell-cell adhesion Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion. got7fsn_ti regulation of leukocyte adhesion|regulation of leukocyte cell adhesion Exogenous expression of ASS1 or NOS3 in HUVECs enhances NO production and inhibits monocyte adhesion rl 2014-05-19T15:29:58Z biological_process owl:Class
GO:0070493 biolink:NamedThing thrombin-activated receptor signaling pathway The series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands. got7fsn_ti thrombin receptor signalling pathway|thrombin receptor signaling pathway biological_process owl:Class
GO:0098662 biolink:NamedThing inorganic cation transmembrane transport A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti monovalent inorganic cation transport|transmembrane inorganic cation transport|divalent inorganic cation transport|inorganic cation membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. GO:0072511|GO:0015672 biological_process owl:Class
GO:0045277 biolink:NamedThing respiratory chain complex IV A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). got7fsn_ti cytochrome c oxidase complex|electron transport complex IV GO:0045287 cellular_component owl:Class
GO:0102244 biolink:NamedThing 3-aminopropanal dehydrogenase activity Catalysis of the reaction: 3-ammoniopropanal + NAD + H2O <=> 2 H+ + beta-alanine + NADH. got7fsn_ti MetaCyc:RXN-12332 molecular_function owl:Class
GO:0098630 biolink:NamedThing aggregation of unicellular organisms The clustering together of unicellular organisms in suspension form aggregates. got7fsn_ti aggregation of single cell organisms biological_process owl:Class
GO:0098743 biolink:NamedThing cell aggregation The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation. got7fsn_ti biological_process owl:Class
GO:0044348 biolink:NamedThing plant-type cell wall cellulose catabolic process The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall. got7fsn_ti plant-type cell wall polysaccharide breakdown jl 2011-07-28T01:48:23Z biological_process owl:Class
GO:0036213 biolink:NamedThing contractile ring contraction The process of an actomyosin ring getting smaller in diameter. got7fsn_ti contractile ring constriction https://github.com/geneontology/go-ontology/issues/21855 This term can be used to annotate contraction of either bacterial or fungal contractile rings. bf 2012-04-26T02:58:18Z biological_process owl:Class
GO:0062196 biolink:NamedThing regulation of lysosome size Any process that modulates the size of a lysosome. got7fsn_ti dph 2019-12-09T21:06:44Z biological_process owl:Class
GO:0140026 biolink:NamedThing contractile vacuole dissociation from plasma membrane The dissociation of the contractile vacuole after discharge, from the plasma membrane. This interaction is mediated by detethering factors that initiate the process of tubulation and fragmentation of the empty contractile vacuole bladder, which is then reincorporated into the CV network. got7fsn_ti contractile vacuole detethering from plasma membrane pg 2017-05-02T10:16:12Z biological_process owl:Class
GO:0018297 biolink:NamedThing protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine. got7fsn_ti RESID:AA0221 biological_process owl:Class
GO:0042551 biolink:NamedThing neuron maturation A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state. got7fsn_ti biological_process owl:Class
GO:0047857 biolink:NamedThing dihydrouracil oxidase activity Catalysis of the reaction: 5,6-dihydrouracil + O(2) = H(2)O(2) + uracil. got7fsn_ti 5,6-dihydrouracil:oxygen oxidoreductase activity RHEA:12384|KEGG_REACTION:R00975|EC:1.3.3.7|MetaCyc:DIHYDROURACIL-OXIDASE-RXN molecular_function owl:Class
GO:0061662 biolink:NamedThing ISG15 ligase activity Catalysis of the transfer of a ISG15 to a substrate protein via the reaction X-ISG15 + S --> X + S-ISG15, where X is either an E2 or E3 enzyme, the X-ISG15 linkage is a thioester bond, and the S-ISG15 linkage is an isopeptide bond between the C-terminal amino acid of ISG15 and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T13:54:48Z molecular_function owl:Class
GO:0034354 biolink:NamedThing 'de novo' NAD biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. got7fsn_ti de novo NAD biosynthetic process from tryptophan biological_process owl:Class
GO:0102701 biolink:NamedThing tricyclene synthase activity Catalysis of the reaction: geranyl diphosphate(3-) <=> tricyclene + diphosphoric acid. got7fsn_ti RHEA:32687|EC:4.2.3.105|MetaCyc:RXN-5121 molecular_function owl:Class
GO:0006475 biolink:NamedThing internal protein amino acid acetylation The addition of an acetyl group to a non-terminal amino acid in a protein. got7fsn_ti biological_process owl:Class
GO:0002063 biolink:NamedThing chondrocyte development The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. got7fsn_ti biological_process owl:Class
GO:0007535 biolink:NamedThing donor selection The process that determines which donor locus a cell uses, in preference to another, in mating type switching. got7fsn_ti donor preference biological_process owl:Class
GO:0004633 biolink:NamedThing phosphopantothenoylcysteine decarboxylase activity Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate. got7fsn_ti N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)|N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity|PPC-decarboxylase activity|N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity|4-phosphopantothenoyl-L-cysteine decarboxylase activity|4-phosphopantotheoylcysteine decarboxylase activity MetaCyc:P-PANTOCYSDECARB-RXN|EC:4.1.1.36|Reactome:R-HSA-196840|RHEA:16793|KEGG_REACTION:R03269 molecular_function owl:Class
GO:0022614 biolink:NamedThing membrane to membrane docking The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere. got7fsn_ti membrane-membrane docking biological_process owl:Class
GO:0001635 biolink:NamedThing calcitonin gene-related peptide receptor activity Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. got7fsn_ti CGRP receptor|calcitonin gene-related polypeptide receptor activity Wikipedia:CALCRL molecular_function owl:Class
GO:0035125 biolink:NamedThing embryonic anal fin morphogenesis The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. got7fsn_ti biological_process owl:Class
GO:0102186 biolink:NamedThing 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 <=> 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + H2O. got7fsn_ti MetaCyc:RXN-11948 molecular_function owl:Class
GO:0052826 biolink:NamedThing inositol hexakisphosphate 2-phosphatase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate. got7fsn_ti 1D-myo-inositol-hexakisphosphate 2-phosphohydrolase activity ai 2011-11-29T09:52:14Z EC:3.1.3.62|Reactome:R-HSA-1855225 molecular_function owl:Class
GO:0060019 biolink:NamedThing radial glial cell differentiation The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the brain. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0102241 biolink:NamedThing soyasaponin III rhamnosyltransferase activity Catalysis of the reaction: UDP-L-rhamnose + soyasaponin III <=> H+ + UDP + soyasaponin I. got7fsn_ti MetaCyc:RXN-12320|RHEA:31491|EC:2.4.1.273 molecular_function owl:Class
GO:0004525 biolink:NamedThing ribonuclease III activity Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. got7fsn_ti ribonuclease 3 activity|RNase III activity|pre-mRNA 3'-end processing endonuclease Reactome:R-HSA-426464|MetaCyc:3.1.26.3-RXN|EC:3.1.26.3|Reactome:R-HSA-203893|Reactome:R-HSA-203862 molecular_function owl:Class
GO:0008671 biolink:NamedThing 2-dehydro-3-deoxygalactonokinase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+). got7fsn_ti ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity|2-keto-3-deoxygalactonate kinase (phosphorylating)|2-keto-3-deoxy-galactonokinase activity|2-oxo-3-deoxygalactonate kinase activity|2-keto-3-deoxygalactonokinase activity EC:2.7.1.58|MetaCyc:DEHYDDEOXGALACTKIN-RXN|RHEA:16525|KEGG_REACTION:R03387 molecular_function owl:Class
GO:0036212 biolink:NamedThing contractile ring maintenance The process in which the contractile ring is maintained, typically in response to an internal or external cue. got7fsn_ti This term can be used to annotate maintenance of either bacterial or fungal contractile rings. bf 2012-04-26T02:57:39Z biological_process owl:Class
GO:0036360 biolink:NamedThing sorocarp stalk morphogenesis The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum. got7fsn_ti fruiting body stalk morphogenesis bf 2012-09-20T11:21:30Z biological_process owl:Class
GO:0090498 biolink:NamedThing extrinsic component of Golgi membrane The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to Golgi membrane tb 2012-10-18T14:12:48Z cellular_component owl:Class
GO:0034335 biolink:NamedThing DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria. got7fsn_ti DNA gyrase activity|DNA-gyrase activity Note that this term was reinstated from obsolete. molecular_function owl:Class
GO:0050530 biolink:NamedThing glucosylglycerol 3-phosphatase activity Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H(2)O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate. got7fsn_ti StpA|salt tolerance protein A|2-(beta-D-glucosyl)-sn-glycerol-3-phosphate phosphohydrolase activity MetaCyc:3.1.3.69-RXN|EC:3.1.3.69|KEGG_REACTION:R05791|RHEA:22652 molecular_function owl:Class
GO:0097118 biolink:NamedThing neuroligin clustering involved in postsynaptic membrane assembly The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons. got7fsn_ti neuroligin clustering|Nlgn clustering|postsynaptic neuroligin clustering pr 2011-07-31T05:47:25Z biological_process owl:Class
GO:0097732 biolink:NamedThing 9+2 non-motile cilium A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme). got7fsn_ti 9+2 immotile cilium|non-motile 9+2 cilium This type of cilia may be present in solitary (e.g. in inner hair cells) or in multiple copies (e.g. in olfactory neurons). pr 2016-09-29T14:07:33Z cellular_component owl:Class
GO:0097730 biolink:NamedThing non-motile cilium A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. got7fsn_ti immotile primary cilium|nonmotile primary cilia|immotile cilium|sensory cilium|nonmotile cilium|nonmotile primary cilium pr 2016-09-29T14:02:11Z GO:0031513 cellular_component owl:Class
GO:0046351 biolink:NamedThing disaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of disaccharides, sugars composed of two monosaccharide units. got7fsn_ti disaccharide formation|disaccharide biosynthesis|disaccharide synthesis|disaccharide anabolism biological_process owl:Class
GO:0033548 biolink:NamedThing myo-inositol hexakisphosphate biosynthetic process, lipid-independent The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, by the successively phosphorylation of myo-inositol or an inositol trisphosphate; the inositol trisphosphates that may be used by this pathway are inositol 3,4,5-trisphosphate and inositol 3,4,6trisphosphate. got7fsn_ti myo-inositol hexakisphosphate biosynthesis, lipid-independent|phytate biosynthesis, lipid-independent|myo-inositol hexakisphosphate anabolism, lipid-independent|myo-inositol hexakisphosphate synthesis, lipid-independent|myo-inositol hexakisphosphate formation, lipid-independent|phytate biosynthetic process, lipid-independent MetaCyc:PWY-4661 biological_process owl:Class
GO:0072658 biolink:NamedThing maintenance of protein location in membrane Any process in which a protein is maintained in a specific location in a membrane, and is prevented from moving elsewhere. got7fsn_ti mah 2011-02-14T02:39:41Z biological_process owl:Class
GO:0050168 biolink:NamedThing pentanamidase activity Catalysis of the reaction: H(2)O + pentanamide = NH(4)(+) + valerate. got7fsn_ti pentanamide amidohydrolase activity|valeramidase activity EC:3.5.1.50|KEGG_REACTION:R02938|RHEA:10000|MetaCyc:PENTANAMIDASE-RXN molecular_function owl:Class
GO:0102718 biolink:NamedThing TRIBOA-glucoside methyltransferase activity Catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine <=> (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+. got7fsn_ti RHEA:32099|MetaCyc:RXN-6687|EC:2.1.1.241 molecular_function owl:Class
GO:0060683 biolink:NamedThing regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the epithelial cells to the mesenchymal cells of the salivary gland. got7fsn_ti regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signalling dph 2009-06-03T06:30:56Z biological_process owl:Class
GO:0030537 biolink:NamedThing larval behavior Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics. got7fsn_ti larval behaviour See also the biological process term 'behavior ; GO:0007610'. GO:0017037 biological_process owl:Class
GO:0035760 biolink:NamedThing cytoplasmic polyadenylation-dependent rRNA catabolic process The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate. got7fsn_ti cytoplasmic poly(A)-dependent rRNA catabolic process bf 2011-03-25T02:14:50Z biological_process owl:Class
GO:0043634 biolink:NamedThing polyadenylation-dependent ncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA. got7fsn_ti poly(A)-dependent ncRNA catabolic process biological_process owl:Class
GO:0014832 biolink:NamedThing urinary bladder smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract. got7fsn_ti biological_process owl:Class
GO:0035280 biolink:NamedThing miRNA loading onto RISC involved in gene silencing by miRNA The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC). got7fsn_ti microRNA loading onto RISC involved in gene silencing by microRNA|miRNA-mediated gene silencing, miRNA loading onto RISC|miRISC assembly|gene silencing by miRNA, miRNA loading onto RISC biological_process owl:Class
GO:0002521 biolink:NamedThing leukocyte differentiation The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue. got7fsn_ti leucocyte differentiation|immune cell differentiation biological_process owl:Class
GO:0042188 biolink:NamedThing 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide. got7fsn_ti 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane degradation|DDT catabolic process|1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane breakdown|DDT catabolism|1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolism biological_process owl:Class
GO:0102764 biolink:NamedThing 6-deoxotyphasterol C-23 hydroxylase activity Catalysis of the reaction: 6-deoxotyphasterol + O2 + a reduced electron acceptor = 6-deoxocastasterone + H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-777 molecular_function owl:Class
GO:0010647 biolink:NamedThing positive regulation of cell communication Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. got7fsn_ti biological_process owl:Class
GO:0051215 biolink:NamedThing RNAi-mediated antiviral immunity against DNA virus Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing. In plants, DCL3 is the primary Dicer to detect DNA viruses. got7fsn_ti DNA virus induced gene silencing|DNA VIGS|DNA virus-induced gene silencing https://github.com/geneontology/go-ontology/issues/19958 biological_process owl:Class
GO:0035080 biolink:NamedThing heat shock-mediated polytene chromosome puffing The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus. got7fsn_ti biological_process owl:Class
GO:1990174 biolink:NamedThing phosphodiesterase decapping endonuclease activity Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA. got7fsn_ti G(5')pppN pyrophosphatase activity tb 2013-08-26T17:51:00Z molecular_function owl:Class
GO:0071853 biolink:NamedThing fungal-type cell wall disassembly A cellular process that results in the breakdown of a fungal-type cell wall. got7fsn_ti mah 2010-09-10T03:10:47Z biological_process owl:Class
GO:0097514 biolink:NamedThing sexual spore wall A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis. got7fsn_ti pr 2013-10-16T15:10:32Z cellular_component owl:Class
GO:0099115 biolink:NamedThing chromosome, subtelomeric region A region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes. This region is usually heterochromatin. got7fsn_ti sub-telomeric heterochromatin|subtelomeric heterochromatin|subtelomere|nuclear subtelomeric heterochromatin https://github.com/geneontology/go-ontology/issues/19086 vw 2014-07-18T13:32:59Z GO:1990421|GO:1990707 SO:0001997 cellular_component owl:Class
GO:0008440 biolink:NamedThing inositol-1,4,5-trisphosphate 3-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). got7fsn_ti inositol-trisphosphate 3-kinase activity|IP3K activity|Ins(1,4,5)P3 3-kinase activity|1D-myo-inositol-trisphosphate 3-kinase activity|inositol trisphosphate 3-kinase activity|IP3 3-kinase activity|ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity|ins(1,4,5)P(3) 3-kinase activity Reactome:R-HSA-1855233|RHEA:11020|KEGG_REACTION:R03433|EC:2.7.1.127|MetaCyc:2.7.1.127-RXN|Reactome:R-HSA-1855153 molecular_function owl:Class
GO:0070721 biolink:NamedThing ISGF3 complex A transcription factor complex that consists of a Stat1-Stat2 heterodimer and the IRF9 protein. got7fsn_ti interferon-stimulated gene factor 3 transcription complex mah 2009-06-10T05:22:05Z cellular_component owl:Class
GO:0010286 biolink:NamedThing heat acclimation Any process that increases heat tolerance of an organism in response to high temperatures. got7fsn_ti thermotolerance biological_process owl:Class
GO:0048484 biolink:NamedThing enteric nervous system development The process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. got7fsn_ti biological_process owl:Class
GO:0090424 biolink:NamedThing phytochelatin-metal-sulfur complex formation A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex. got7fsn_ti HWM phytochelatin complex formation|high molecular weight phytochelatin complex formation tb 2012-04-20T03:46:45Z biological_process owl:Class
GO:0018181 biolink:NamedThing peptidyl-arginine C5-methylation The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine. got7fsn_ti peptidyl-arginine 5-methylation RESID:AA0272 biological_process owl:Class
GO:0035245 biolink:NamedThing peptidyl-arginine C-methylation The addition of a methyl group onto a carbon atom of an arginine residue in a protein. got7fsn_ti biological_process owl:Class
GO:0018485 biolink:NamedThing salicylaldehyde dehydrogenase activity Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+. got7fsn_ti salicylaldehyde:NAD+ oxidoreductase activity EC:1.2.1.65|MetaCyc:1.2.1.65-RXN|RHEA:18537|UM-BBD_enzymeID:e0256 molecular_function owl:Class
GO:0000454 biolink:NamedThing snoRNA guided rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation. got7fsn_ti biological_process owl:Class
GO:0038138 biolink:NamedThing ERBB4-ERBB4 signaling pathway A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti HER4-HER4 signaling pathway|ERBB4 homodimeric signaling pathway|ERBB4-ERBB4 signalling pathway bf 2012-03-30T11:41:05Z biological_process owl:Class
GO:1990622 biolink:NamedThing CHOP-ATF3 complex A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits. got7fsn_ti CHOP-ATF3 heterodimeric complex|CHOP-ATF3 heterodimer|ATF3-CHOP complex|GADD153-ATF3 complex bf 2015-01-29T16:43:19Z cellular_component owl:Class
GO:0002247 biolink:NamedThing clearance of damaged tissue involved in inflammatory response wound healing The series of events leading to removal of necrotic debris that contribute to an inflammatory response. got7fsn_ti clearance of damaged tissue during inflammatory response biological_process owl:Class
GO:0043791 biolink:NamedThing dimethylamine methyltransferase activity Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine. got7fsn_ti DMAMT 1|DMA methyltransferase 1|dimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity|dimethylamine:corrinoid methyltransferase activity|mtbB1|MT1 This function is the first step in the pathway of methanogenesis from dimethylamine. RHEA:41175|MetaCyc:RXN-8100|EC:2.1.1.249 molecular_function owl:Class
GO:0015478 biolink:NamedThing oligosaccharide transporting porin activity Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. got7fsn_ti raffinose porin molecular_function owl:Class
GO:0015157 biolink:NamedThing oligosaccharide transmembrane transporter activity Enables the transfer of oligosaccharide from one side of a membrane to the other. got7fsn_ti endosomal oligosaccharide transporter molecular_function owl:Class
GO:0046145 biolink:NamedThing D-alanine family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of D-alanine and related amino acids. got7fsn_ti D-alanine family amino acid formation|D-alanine family amino acid synthesis|D-alanine family amino acid anabolism|D-alanine family amino acid biosynthesis biological_process owl:Class
GO:0018019 biolink:NamedThing N-terminal peptidyl-glutamine methylation The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative. got7fsn_ti RESID:AA0071 biological_process owl:Class
GO:0010639 biolink:NamedThing negative regulation of organelle organization Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle. got7fsn_ti negative regulation of organelle organisation|negative regulation of organelle organization and biogenesis biological_process owl:Class
GO:0102044 biolink:NamedThing 3-chlorobenzoate-4,5-oxygenase activity Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-10421 molecular_function owl:Class
GO:0047250 biolink:NamedThing 4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity Catalysis of the reaction: 4-hydroxybenzoate + UDP-D-glucose = 4-(beta-D-glucosyloxy)benzoate + H(+) + UDP. got7fsn_ti UDP-glucose:4-(beta-D-glucopyranosyloxy)benzoic acid glucosyltransferase activity|HBA glucosyltransferase activity|PHB-O-glucosyltransferase activity|uridine diphosphoglucose-4-hydroxybenzoate glucosyltransferase activity|UDPglucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity|UDP-glucose:4-hydroxybenzoate 4-O-beta-D-glucosyltransferase activity|PHB glucosyltransferase activity|p-hydroxybenzoate glucosyltransferase activity MetaCyc:2.4.1.194-RXN|KEGG_REACTION:R01304|EC:2.4.1.194|RHEA:15153 molecular_function owl:Class
GO:0016435 biolink:NamedThing rRNA (guanine) methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine. got7fsn_ti molecular_function owl:Class
GO:0047174 biolink:NamedThing putrescine N-hydroxycinnamoyltransferase activity Catalysis of the reaction: caffeoyl-CoA + putrescine = N-caffeoylputrescine + CoA + H(+). got7fsn_ti putrescine hydroxycinnamoyl transferase activity|putrescine hydroxycinnamoyltransferase activity|caffeoyl-CoA:putrescine N-(3,4-dihydroxycinnamoyl)transferase activity|PHT|hydroxycinnamoyl-CoA:putrescine hydroxycinnamoyltransferase activity|caffeoyl-CoA putrescine N-caffeoyl transferase activity EC:2.3.1.138|RHEA:12436|KEGG_REACTION:R01944|MetaCyc:2.3.1.138-RXN molecular_function owl:Class
GO:0019534 biolink:NamedThing toxin transmembrane transporter activity Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. got7fsn_ti molecular_function owl:Class
GO:0006213 biolink:NamedThing pyrimidine nucleoside metabolic process The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). got7fsn_ti pyrimidine nucleoside metabolism|pyrimidine metabolism|pyrimidine metabolic process biological_process owl:Class
GO:0061177 biolink:NamedThing type Is terminal bouton Terminal inflated portion of the axon of a glutamatergic neuron, containing the specialized apparatus necessary for the phasic release neurotransmitters that will induce the contraction of muscle. Type Is terminal boutons are smaller than type Ib terminal boutons. got7fsn_ti type Is terminal button dph 2010-07-13T09:25:15Z cellular_component owl:Class
GO:0072089 biolink:NamedThing stem cell proliferation The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. got7fsn_ti mah 2010-02-08T02:03:36Z biological_process owl:Class
GO:0036393 biolink:NamedThing thiocyanate peroxidase activity Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate. got7fsn_ti lactoperoxidase activity bf 2013-06-20T16:03:57Z molecular_function owl:Class
GO:0097187 biolink:NamedThing dentinogenesis The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin. got7fsn_ti dentin development|dentine development pr 2011-11-21T09:04:17Z biological_process owl:Class
GO:0042475 biolink:NamedThing odontogenesis of dentin-containing tooth The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel. got7fsn_ti tooth development|odontogeny|odontogenesis of dentine-containing teeth|odontogenesis of dentine-containing tooth|odontosis Note that placoid scales found in the cartilaginous fishes presumably develop through the same processes, but are found on the dermis, rather than in the mouth or pharynx. See Wikipedia:Placoid_scale#Placoid_scales. biological_process owl:Class
GO:0034930 biolink:NamedThing 1-hydroxypyrene sulfotransferase activity Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX. got7fsn_ti UM-BBD_reactionID:r0952 molecular_function owl:Class
GO:0018619 biolink:NamedThing benzene 1,2-dioxygenase activity Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+). got7fsn_ti benzene dioxygenase activity|benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)|benzene hydroxylase activity KEGG_REACTION:R03543|MetaCyc:BENZENE-12-DIOXYGENASE-RXN|UM-BBD_reactionID:r0079|EC:1.14.12.3|RHEA:13813 molecular_function owl:Class
GO:0032613 biolink:NamedThing interleukin-10 production The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-10 biosynthetic process|IL-10 production|interleukin-10 secretion GO:0072608|GO:0042091 biological_process owl:Class
GO:0004634 biolink:NamedThing phosphopyruvate hydratase activity Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. got7fsn_ti 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)|phosphoenolpyruvate hydratase activity|2-phosphoglycerate dehydratase activity|2-phosphoglycerate enolase activity|14-3-2-protein|nervous-system specific enolase|enolase activity|2-phospho-D-glycerate hydro-lyase activity|2-phosphoglyceric dehydratase activity|gamma-enolase activity|2-phospho-D-glycerate-hydrolase activity RHEA:10164|EC:4.2.1.11|MetaCyc:2PGADEHYDRAT-RXN|Reactome:R-HSA-71660|Reactome:R-HSA-70494 molecular_function owl:Class
GO:0019346 biolink:NamedThing transsulfuration The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. got7fsn_ti transsulphuration|homocysteine-cysteine interconversion MetaCyc:PWY-801|Wikipedia:Transsulfuration_pathway biological_process owl:Class
GO:0050667 biolink:NamedThing homocysteine metabolic process The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. got7fsn_ti homocysteine metabolism|Hcy metabolism|Hcy metabolic process biological_process owl:Class
GO:0004890 biolink:NamedThing GABA-A receptor activity Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. got7fsn_ti ionotropic GABA receptor activity Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. molecular_function owl:Class
GO:0000410 biolink:NamedThing carbon catabolite repression of transcription by galactose A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances. got7fsn_ti down-regulation of transcription by galactose|down regulation of transcription by galactose|inhibition of transcription by galactose|downregulation of transcription by galactose biological_process owl:Class
GO:0042160 biolink:NamedThing lipoprotein modification The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. got7fsn_ti biological_process owl:Class
GO:0007632 biolink:NamedThing visual behavior The behavior of an organism in response to a visual stimulus. got7fsn_ti behavioural response to visual stimulus|visual behaviour|behavioral response to visual stimulus biological_process owl:Class
GO:0051933 biolink:NamedThing amino acid neurotransmitter reuptake The uptake of amino acid neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. got7fsn_ti amino acid neurotransmitter recycling|amino acid uptake during transmission of nerve impulse|amino acid neurotransmitter import into glial cell|amino acid neurotransmitter import into neuron biological_process owl:Class
GO:0103005 biolink:NamedThing 9,10-epoxystearate hydrolase activity Catalysis of the reaction: 9,10-epoxystearate + H2O <=> (9R,10S)-dihydroxystearate. got7fsn_ti MetaCyc:RXN-9806 molecular_function owl:Class
GO:0003288 biolink:NamedThing ventricular septum intermedium morphogenesis The developmental process in which a ventricular septum intermedium is generated and organized. got7fsn_ti dph 2009-10-20T10:58:48Z biological_process owl:Class
GO:0046334 biolink:NamedThing octopamine catabolic process The chemical reactions and pathways resulting in the breakdown of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. got7fsn_ti octopamine degradation|octopamine breakdown|octopamine catabolism biological_process owl:Class
GO:0075210 biolink:NamedThing suppression by symbiont of host cAMP-mediated signal transduction Any process in which the symbiont organism stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host cAMP-mediated signaling|negative regulation by symbiont of host cAMP-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "Negative regulation by host of symbiont cAMP-mediated signal transduction ; GO:0075207". biological_process owl:Class
GO:0051921 biolink:NamedThing adenosylcobyric acid synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 4 L-glutamine + adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H(2)O = 4 L-glutamate + adenosylcobyrate + 4 ADP + 8 H(+) + 4 phosphate. got7fsn_ti 5'-deoxy-5'-adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase activity|cobyric acid synthase activity|Ado-cobyric acid synthase [glutamine hydrolyzing] activity|adenosylcobyrinic-acid-a,c-diamide:L-glutamine amido-ligase (ADP-forming)|adenosylcobyric acid synthase (glutamine-hydrolysing) activity|CobQ activity KEGG_REACTION:R05225|EC:6.3.5.10|MetaCyc:R345-RXN|RHEA:23256 molecular_function owl:Class
GO:0102902 biolink:NamedThing isopimaradienal hydroxylase activity Catalysis of the reaction: isopimaradienal + NADPH + O2 <=> isopimaric acid + NADP + H2O. got7fsn_ti MetaCyc:RXN-8538 molecular_function owl:Class
GO:0048903 biolink:NamedThing anterior lateral line neuromast hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. got7fsn_ti biological_process owl:Class
GO:0043152 biolink:NamedThing induction of bacterial agglutination Any process in which infecting bacteria are clumped together by a host organism. got7fsn_ti biological_process owl:Class
GO:0019731 biolink:NamedThing antibacterial humoral response An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster. got7fsn_ti GO:0019733|GO:0006961 biological_process owl:Class
GO:0001068 biolink:NamedThing transcription regulatory region RNA binding Binding to a RNA region within the transcript that regulates the transcription of a gene, cistron, or operon. got7fsn_ti krc 2010-10-21T04:15:32Z molecular_function owl:Class
GO:0103043 biolink:NamedThing 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity Catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> H+ + alpha-D-ribose 1,5-bisphosphate. got7fsn_ti EC:3.1.4.55|RHEA:34795|MetaCyc:RXN0-6710 molecular_function owl:Class
GO:0001964 biolink:NamedThing startle response An action or movement due to the application of a sudden unexpected stimulus. got7fsn_ti Wikipedia:Startle_reaction biological_process owl:Class
GO:0052651 biolink:NamedThing monoacylglycerol catabolic process The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. got7fsn_ti monoacylglycerol breakdown|monoacylglycerol catabolism|monoacylglycerol degradation 2010-09-23T09:26:36Z biological_process owl:Class
GO:0047702 biolink:NamedThing beta-lysine 5,6-aminomutase activity Catalysis of the reaction: (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate. got7fsn_ti b-lysine 5,6-aminomutase activity|L-beta-lysine 5,6-aminomutase activity|beta-lysine mutase activity|(3S)-3,6-diaminohexanoate 5,6-aminomutase activity EC:5.4.3.3|MetaCyc:BETA-LYSINE-56-AMINOMUTASE-RXN|RHEA:21736|KEGG_REACTION:R03275 molecular_function owl:Class
GO:0103047 biolink:NamedThing methyl beta-D-glucoside 6-phosphate glucohydrolase activity Catalysis of the reaction: methyl beta-D-glucoside 6-phosphate + H2O = beta-D-glucose 6-phosphate + methanol. got7fsn_ti EC:3.2.1.86|MetaCyc:RXN0-6994 molecular_function owl:Class
GO:0034017 biolink:NamedThing trans-2-decenoyl-acyl-carrier-protein isomerase activity Catalysis of the reaction: trans-dec-2-enoyl-[acyl-carrier protein] = cis-dec-3-enoyl-[acyl-carrier protein]. got7fsn_ti trans-2-decenoyl-ACP isomerase activity|trans-2-cis-3-decenoyl-ACP isomerase activity|beta-hydroxydecanoyl thioester dehydrase activity|trans-2, cis-3 decenoyl-ACP isomerase activity|decenoyl-acyl-carrier-protein delta2-trans-delta3-cis-isomerase activity|trans-2, cis-3 decenoyl-[acyl-carrier-protein] isomerase activity|trans-2,cis-3-decenoyl-ACP isomerase activity|FabM GO:0043832 RHEA:23568|EC:5.3.3.14|MetaCyc:5.3.3.14-RXN molecular_function owl:Class
GO:0004667 biolink:NamedThing prostaglandin-D synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2). got7fsn_ti (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity|prostaglandin-R-prostaglandin D isomerase activity|prostaglandin-H2 D-isomerase activity|PGH-PGD isomerase activity|prostaglandin D2 synthase activity|PGD2 synthase activity RHEA:10600|EC:5.3.99.2|MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN|KEGG_REACTION:R02266|Reactome:R-HSA-2161620|Reactome:R-HSA-2161701 molecular_function owl:Class
GO:0038061 biolink:NamedThing NIK/NF-kappaB signaling The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). got7fsn_ti NIK/NF-kappaB signal transduction|noncanonical nuclear factor kappaB (NF-kappaB) pathway|noncanonical NF-kappaB signaling|p52-dependent NF-kappaB signaling|NIK/NF-kappaB cascade|non-canonical NF-KB signaling bf 2012-01-16T05:44:46Z biological_process owl:Class
GO:0097371 biolink:NamedThing MDM2/MDM4 family protein binding Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53. got7fsn_ti pr 2012-08-08T16:20:59Z molecular_function owl:Class
GO:1990893 biolink:NamedThing mitotic chromosome centromere condensation The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis. got7fsn_ti mitotic chromosome condensation at kinetochore vw 2015-11-03T14:26:29Z biological_process owl:Class
GO:1901143 biolink:NamedThing insulin catabolic process The chemical reactions and pathways resulting in the breakdown of insulin. got7fsn_ti insulin catabolism|insulin breakdown|insulin degradation pm 2012-07-13T12:33:03Z biological_process owl:Class
GO:1901142 biolink:NamedThing insulin metabolic process The chemical reactions and pathways involving insulin. got7fsn_ti insulin metabolism pm 2012-07-13T12:32:40Z biological_process owl:Class
GO:0050137 biolink:NamedThing NADPH peroxidase activity Catalysis of the reaction: H(2)O(2) + H(+) + NADPH = 2 H(2)O + NADP(+). got7fsn_ti NADPH:hydrogen-peroxide oxidoreductase activity|TPN peroxidase activity|TPNH peroxidase activity|nicotinamide adenine dinucleotide phosphate peroxidase activity|NADP peroxidase activity|triphosphopyridine nucleotide peroxidase activity RHEA:15173|KEGG_REACTION:R00113|MetaCyc:NADPH-PEROXIDASE-RXN|EC:1.11.1.2 molecular_function owl:Class
GO:0034736 biolink:NamedThing cholesterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + cholesterol = a cholesterol ester + CoA. got7fsn_ti acyl coenzyme A-cholesterol-O-acyltransferase activity|cholesterol acyltransferase activity|acyl-CoA:cholesterol acyltransferase activity|acylcoenzyme A:cholesterol O-acyltransferase activity|cholesterol ester synthetase activity|ACAT activity|acyl-CoA:cholesterol O-acyltransferase activity|cholesteryl ester synthetase activity EC:2.3.1.26|KEGG_REACTION:R01461|MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN|Reactome:R-HSA-8876696|RHEA:17729 molecular_function owl:Class
GO:0004772 biolink:NamedThing sterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester. got7fsn_ti sterol-ester synthase activity|sterol-ester synthetase activity GO:0017066 molecular_function owl:Class
GO:0030378 biolink:NamedThing serine racemase activity Catalysis of the synthesis of free D-serine from L-serine. got7fsn_ti Reactome:R-HSA-9014766|RHEA:10980|MetaCyc:5.1.1.18-RXN|EC:5.1.1.18 molecular_function owl:Class
GO:0097376 biolink:NamedThing interneuron axon guidance The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions. got7fsn_ti pr 2012-10-01T10:18:35Z biological_process owl:Class
GO:0002402 biolink:NamedThing B cell tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells. got7fsn_ti B cell tolerance induction in MALT biological_process owl:Class
GO:0070136 biolink:NamedThing beta-1,2-oligomannoside biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,2-linked oligomannosides, which are found in fungal cell wall phosphopeptidomannan and phospholipomannan. got7fsn_ti beta-1,2-oligomannoside biosynthesis|beta-1,2-oligomannoside formation|beta-1,2-oligomannoside synthesis|beta-1,2-oligomannoside anabolism biological_process owl:Class
GO:0016690 biolink:NamedThing diarylpropane peroxidase activity Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O. got7fsn_ti diarylpropane oxygenase activity|diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)|lignin peroxidase activity|1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity|ligninase activity|ligninase I activity|LiP activity EC:1.11.1.14|RHEA:30271|MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN molecular_function owl:Class
GO:0001853 biolink:NamedThing complement component C3dg binding Binding to a C3dg product of the complement cascade. got7fsn_ti molecular_function owl:Class
GO:0043817 biolink:NamedThing phosphosulfolactate synthase activity Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite. got7fsn_ti PSL synthase activity|(2R)-O-phospho-3-sulfolactate sulfo-lyase (phosphoenolpyruvate-forming)|(2R)-O-phospho-3-sulfolactate sulfo-lyase activity|(2R)-phospho-3-sulfolactate synthase activity MetaCyc:4.4.1.19-RXN|KEGG_REACTION:R07476|EC:4.4.1.19|RHEA:22784|MetaCyc:R228-RXN molecular_function owl:Class
GO:0039663 biolink:NamedThing membrane fusion involved in viral entry into host cell Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell. got7fsn_ti fusion of virus membrane with host membrane|fusion of virus membrane with host membrane during viral entry|viral entry into host cell via membrane fusion bf 2013-08-29T10:15:11Z biological_process owl:Class
GO:0042410 biolink:NamedThing 6-carboxyhexanoate-CoA ligase activity Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA. got7fsn_ti 6-carboxyhexanoate:CoA ligase (AMP-forming)|pimeloyl-CoA synthetase activity|pimelyl-CoA synthetase activity|6-carboxyhexanoyl-CoA synthetase activity MetaCyc:6-CARBOXYHEXANOATE--COA-LIGASE-RXN|RHEA:14781|KEGG_REACTION:R03209|EC:6.2.1.14 molecular_function owl:Class
GO:0004185 biolink:NamedThing serine-type carboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). got7fsn_ti serine carboxypeptidase activity https://github.com/geneontology/go-ontology/issues/19681 MetaCyc:3.4.16.5-RXN|EC:3.4.16.5|EC:3.4.16.6|MetaCyc:3.4.16.6-RXN|Reactome:R-HSA-158251|EC:3.4.16.-|EC:3.4.16.2|MetaCyc:3.4.16.2-RXN molecular_function owl:Class
GO:0030184 biolink:NamedThing nitric oxide transmembrane transporter activity Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0004528 biolink:NamedThing phosphodiesterase I activity Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. got7fsn_ti 5'-nucleotide phosphodiesterase activity|5'-phosphodiesterase activity|5'-exonuclease activity|PDE I activity|5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity|oligonucleate 5'-nucleotidohydrolase activity|5'-PDE activity|5'-NPDase activity|exonuclease I activity|alkaline phosphodiesterase activity|5'-PDase activity|orthophosphoric diester phosphohydrolase activity|5'NPDE activity|phosphodiesterase activity|nucleotide pyrophosphatase/phosphodiesterase I activity MetaCyc:3.1.4.1-RXN|EC:3.1.4.1 molecular_function owl:Class
GO:0043154 biolink:NamedThing negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process. got7fsn_ti downregulation of caspase activity|negative regulation of caspase activation|down-regulation of caspase activity|inhibition of caspase activity|negative regulation of caspase activity|inhibition of caspase activation|down regulation of caspase activity GO:0001719 biological_process owl:Class
GO:0000421 biolink:NamedThing autophagosome membrane The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered. got7fsn_ti autophagic vacuole membrane cellular_component owl:Class
GO:0005774 biolink:NamedThing vacuolar membrane The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. got7fsn_ti cellular_component owl:Class
GO:2001152 biolink:NamedThing negative regulation of renal water transport Any process that stops, prevents or reduces the frequency, rate or extent of renal water transport. got7fsn_ti yaf 2011-10-24T11:37:57Z biological_process owl:Class
GO:0102511 biolink:NamedThing pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + vanillate + H+. got7fsn_ti EC:2.4.1.300|MetaCyc:RXN-14440 molecular_function owl:Class
GO:0035647 biolink:NamedThing 3-oxo-delta(4,5)-steroid 5-beta-reductase activity Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H(+) = a 5-beta-3-oxo-steroid + NADP(+). got7fsn_ti 3-oxo-delta4,5-steroid 5beta-reductase bf 2011-01-24T01:31:30Z molecular_function owl:Class
GO:0016203 biolink:NamedThing muscle attachment The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall). got7fsn_ti biological_process owl:Class
GO:0050330 biolink:NamedThing theanine hydrolase activity Catalysis of the reaction: N(5)-ethyl-L-glutamine + H(2)O = L-glutamate + ethylamine. got7fsn_ti N5-ethyl-L-glutamine amidohydrolase activity|5-N-ethyl-L-glutamine amidohydrolase activity|L-theanine amidohydrolase activity KEGG_REACTION:R02930|RHEA:18013|MetaCyc:THEANINE-HYDROLASE-RXN|EC:3.5.1.65 molecular_function owl:Class
GO:0008863 biolink:NamedThing formate dehydrogenase (NAD+) activity Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH. got7fsn_ti N-FDH|formate:NAD+ oxidoreductase|NAD-dependent formate dehydrogenase|formate dehydrogenase (NAD)|formic hydrogen-lyase|formic acid dehydrogenase|FDH II|NAD-formate dehydrogenase|formate hydrogenlyase|NAD-linked formate dehydrogenase|formate benzyl-viologen oxidoreductase|formate-NAD oxidoreductase|FDH I GO:0018476 EC:1.17.1.9|UM-BBD_reactionID:r0103|MetaCyc:FORMATEDEHYDROG-RXN|KEGG_REACTION:R00519|MetaCyc:1.2.1.2-RXN|RHEA:15985 molecular_function owl:Class
GO:0043895 biolink:NamedThing cyclomaltodextrin glucanotransferase activity Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond. got7fsn_ti cyclomaltodextrin glucotransferase|cyclomaltodextrin glycosyltransferase|beta-cyclodextrin glucanotransferase|BMA|gamma-cyclodextrin glycosyltransferase|alpha-cyclodextrin glucanotransferase|1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (cyclizing)|konchizaimu|neutral-cyclodextrin glycosyltransferase|CGTase|beta-cyclodextrin glycosyltransferase|alpha-1,4-glucan 4-glycosyltransferase, cyclizing|cyclodextrin glucanotransferase|Bacillus macerans amylase|cyclodextrin glycosyltransferase|alpha-cyclodextrin glycosyltransferase MetaCyc:2.4.1.19-RXN|EC:2.4.1.19 molecular_function owl:Class
GO:0055077 biolink:NamedThing gap junction hemi-channel activity A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. got7fsn_ti connexon channel activity molecular_function owl:Class
GO:0004780 biolink:NamedThing sulfate adenylyltransferase (ADP) activity Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate. got7fsn_ti ADP:sulfate adenylyltransferase activity|sulphate adenylyltransferase (ADP) activity|ADP-sulfurylase activity|sulfate (adenosine diphosphate) adenylyltransferase activity|adenosine diphosphate sulfurylase activity RHEA:16529|KEGG_REACTION:R00530|EC:2.7.7.5|MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN molecular_function owl:Class
GO:0030779 biolink:NamedThing 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+). got7fsn_ti S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity EC:2.1.1.119|RHEA:18541|MetaCyc:2.1.1.119-RXN|KEGG_REACTION:R04707 molecular_function owl:Class
GO:0052094 biolink:NamedThing formation of haustorium for nutrient acquisition The assembly of a haustorium, a projection from a symbiotic cell or tissue that penetrates the host's tissues for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti formation by organism of haustorium for nutrient acquisition from host|formation by organism of haustoria for nutrient acquisition from host|formation by symbiont of haustorium for nutrient acquisition from host https://github.com/geneontology/go-ontology/issues/20305 biological_process owl:Class
GO:0102416 biolink:NamedThing quercetin gentiotrioside 1,6-glucosyltransferase activity Catalysis of the reaction: quercetin-3-gentiotrioside + UDP-alpha-D-glucose <=> quercetin-3-gentiotetraside + UDP + H+. got7fsn_ti MetaCyc:RXN-13799 molecular_function owl:Class
GO:0033067 biolink:NamedThing macrolide metabolic process The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria. got7fsn_ti macrolide metabolism biological_process owl:Class
GO:0070858 biolink:NamedThing negative regulation of bile acid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. got7fsn_ti inhibition of bile acid biosynthetic process|down regulation of bile acid biosynthetic process|negative regulation of bile acid biosynthesis|downregulation of bile acid biosynthetic process|negative regulation of bile acid formation|down-regulation of bile acid biosynthetic process|negative regulation of bile acid synthesis|negative regulation of bile acid anabolism mah 2009-08-14T03:16:40Z biological_process owl:Class
GO:0097016 biolink:NamedThing L27 domain binding Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner. got7fsn_ti pr 2011-03-23T02:17:51Z molecular_function owl:Class
GO:0001594 biolink:NamedThing trace-amine receptor activity Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. got7fsn_ti molecular_function owl:Class
GO:0002048 biolink:NamedThing pyoverdine metabolic process The chemical reactions and pathways involving the siderochrome pyoverdine. got7fsn_ti pyoverdine metabolism biological_process owl:Class
GO:0062202 biolink:NamedThing Labd-13(16),14-diene-9-ol synthase activity Catalysis of the reaction: peregrinol diphosphate = diphosphate + labd-13(16),14-diene-9-ol. got7fsn_ti dph 2020-01-02T15:46:00Z RHEA:62184 molecular_function owl:Class
GO:2000933 biolink:NamedThing regulation of cellotriose metabolic process Any process that modulates the frequency, rate or extent of cellotriose metabolic process. got7fsn_ti regulation of cellotriose metabolism tt 2011-08-01T12:44:15Z biological_process owl:Class
GO:0034280 biolink:NamedThing ent-sandaracopimaradiene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate. got7fsn_ti ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming] activity|ent-pimaradiene synthase activity MetaCyc:RXN-4884|RHEA:25536|EC:4.2.3.29|KEGG_REACTION:R09120 molecular_function owl:Class
GO:0033463 biolink:NamedThing GGA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GGA codon. got7fsn_ti glycine tRNA Note that in the standard genetic code, GGA codes for glycine. molecular_function owl:Class
GO:0034723 biolink:NamedThing DNA replication-dependent nucleosome organization The formation or destruction of chromatin structures on newly replicated DNA, coupled to strand elongation. got7fsn_ti DNA replication-dependent nucleosome organisation biological_process owl:Class
GO:0019617 biolink:NamedThing protocatechuate catabolic process, meta-cleavage The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate. got7fsn_ti protocatechuate catabolic process to oxaloacetate and pyruvate|3,4-dihydroxybenzoate catabolic process, meta-cleavage|protocatechuate degradation, meta-cleavage|protocatechuate breakdown, meta-cleavage MetaCyc:P184-PWY biological_process owl:Class
GO:0097670 biolink:NamedThing SCF-Ufo1/Pof10 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe). got7fsn_ti pr 2014-10-06T10:29:13Z cellular_component owl:Class
GO:1990026 biolink:NamedThing hippocampal mossy fiber expansion Synaptic expansion of hippocampal mossy fiber axon that makes contact with the thorny excrescences of hippocampal CA3 pyramidal cell dendrites. got7fsn_ti dentate gyrus mossy fiber expansion|dentate gyrus granule cell axonal bouton|mossy fiber expansion pr 2013-02-06T10:31:59Z NIF_Subcellular:nlx_subcell_1005002 cellular_component owl:Class
GO:0016508 biolink:NamedThing long-chain-enoyl-CoA hydratase activity Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms. got7fsn_ti long-chain enoyl coenzyme A hydratase activity|long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity Reactome:R-HSA-2066778|Reactome:R-HSA-390252|MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN|EC:4.2.1.74|Reactome:R-HSA-2066780|Reactome:R-HSA-389986|Reactome:R-HSA-6809263 molecular_function owl:Class
GO:0009779 biolink:NamedThing noncyclic photosynthetic phosphorylation A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II. got7fsn_ti biological_process owl:Class
GO:0031947 biolink:NamedThing negative regulation of glucocorticoid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids. got7fsn_ti inhibition of glucocorticoid biosynthetic process|downregulation of glucocorticoid biosynthetic process|down-regulation of glucocorticoid biosynthetic process|down regulation of glucocorticoid biosynthetic process biological_process owl:Class
GO:0052162 biolink:NamedThing modulation by symbiont of defense-related host calcium ion flux Any process in which an organism modulates the frequency, rate or extent of calcium ion fluxes as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of defense-related calcium ion flux in other organism involved in symbiotic interaction|modulation by organism of defense-related host Ca2+ flux GO:0052301 biological_process owl:Class
GO:0001939 biolink:NamedThing female pronucleus The pronucleus originating from the ovum that is being fertilized. got7fsn_ti cellular_component owl:Class
GO:0061337 biolink:NamedThing cardiac conduction Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles. got7fsn_ti dph 2010-09-29T08:46:05Z biological_process owl:Class
GO:1990410 biolink:NamedThing adrenomedullin receptor signaling pathway A series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell. got7fsn_ti AM receptor signaling pathway An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. bhm 2014-07-02T14:43:31Z biological_process owl:Class
GO:0090246 biolink:NamedThing convergent extension involved in somitogenesis The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis. got7fsn_ti tb 2010-01-22T10:59:06Z biological_process owl:Class
GO:0070221 biolink:NamedThing sulfide oxidation, using sulfide:quinone oxidoreductase A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide:quinone oxidoreductase. got7fsn_ti sulfide oxidation, using sulfide-quinone reductase|sulphide oxidation, using sulfide:quinone oxidoreductase MetaCyc:P222-PWY biological_process owl:Class
GO:0019418 biolink:NamedThing sulfide oxidation The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate. got7fsn_ti sulphide oxidation MetaCyc:P222-PWY biological_process owl:Class
GO:0006301 biolink:NamedThing postreplication repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication. got7fsn_ti postreplication DNA repair Wikipedia:Postreplication_repair biological_process owl:Class
GO:0035912 biolink:NamedThing dorsal aorta morphogenesis The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:22:14Z biological_process owl:Class
GO:0102076 biolink:NamedThing beta,beta-carotene-9',10'-cleaving oxygenase activity Catalysis of the reaction: beta-carotene + O2 <=> 10'-apo-beta-carotenal + beta-ionone. got7fsn_ti RHEA:26389|EC:1.13.11.71|MetaCyc:RXN-10741 molecular_function owl:Class
GO:0034594 biolink:NamedThing phosphatidylinositol trisphosphate phosphatase activity Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate. got7fsn_ti molecular_function owl:Class
GO:0050340 biolink:NamedThing thymidylate 5'-phosphatase activity Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate. got7fsn_ti dTMPase activity|thymidylate 5'-phosphohydrolase activity|thymidylate 5' phosphatase activity|thymidylate 5'-nucleotidase activity|deoxythymidylic 5'-nucleotidase activity|deoxythymidylate 5'-nucleotidase activity|thymidylate nucleotidase activity|deoxythymidylate phosphohydrolase activity EC:3.1.3.35|MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN|RHEA:11080 molecular_function owl:Class
GO:0061259 biolink:NamedThing mesonephric glomerular mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the mesonephros as it progresses from its formation to the mature state. got7fsn_ti dph 2010-08-30T02:22:45Z biological_process owl:Class
GO:0060290 biolink:NamedThing transdifferentiation The conversion of a differentiated cell of one fate into a differentiated cell of another fate without first undergoing cell division or reversion to a more primitive or stem cell-like fate. got7fsn_ti Wikipedia:Transdifferentiation biological_process owl:Class
GO:0106177 biolink:NamedThing cyclic-GMP-AMP hydrolase activity Catalysis of the reaction: cyclic GMP-AMP + 2 H2O = AMP + GMP. got7fsn_ti hjd 2019-03-07T21:06:24Z RHEA:58808 molecular_function owl:Class
GO:0019520 biolink:NamedThing aldonic acid metabolic process The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. got7fsn_ti aldonic acid metabolism biological_process owl:Class
GO:0006524 biolink:NamedThing alanine catabolic process The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid. got7fsn_ti alanine degradation|alanine catabolism|alanine breakdown biological_process owl:Class
GO:0044716 biolink:NamedThing 8-oxo-GDP phosphatase activity Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate. got7fsn_ti jl 2012-10-18T13:32:39Z EC:3.6.1.58|RHEA:62356 molecular_function owl:Class
GO:0072525 biolink:NamedThing pyridine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. got7fsn_ti pyridine and derivative biosynthetic process|pyridine-containing compound synthesis|pyridine-containing compound formation|pyridine-containing compound biosynthesis|pyridine-containing compound anabolism mah 2011-01-04T03:23:01Z biological_process owl:Class
GO:0033679 biolink:NamedThing 3'-5' DNA/RNA helicase activity Unwinding of a DNA/RNA duplex in the 3' to 5' direction, driven by ATP hydrolysis. got7fsn_ti 3' to 5' DNA/RNA helicase activity|ATP-dependent 3' to 5' DNA/RNA helicase activity|ATP-dependent 3'-5' DNA/RNA helicase activity https://github.com/geneontology/go-ontology/issues/21612 GO:0033681 molecular_function owl:Class
GO:0102878 biolink:NamedThing (+)-alpha-barbatene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-alpha-barbatene + diphosphoric acid. got7fsn_ti EC:4.2.3.69|MetaCyc:RXN-8417|RHEA:29499 molecular_function owl:Class
GO:0006809 biolink:NamedThing nitric oxide biosynthetic process The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. got7fsn_ti nitric oxide synthesis|nitric oxide biosynthesis|nitric oxide anabolism|nitric oxide formation biological_process owl:Class
GO:0035178 biolink:NamedThing turning behavior Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source. got7fsn_ti turning behaviour biological_process owl:Class
GO:0006958 biolink:NamedThing complement activation, classical pathway Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. got7fsn_ti complement cascade, classical pathway biological_process owl:Class
GO:0045925 biolink:NamedThing positive regulation of female receptivity Any process that activates or increases the receptiveness of a female to male advances. got7fsn_ti upregulation of female receptivity|up-regulation of female receptivity|activation of female receptivity|stimulation of female receptivity|up regulation of female receptivity biological_process owl:Class
GO:0048922 biolink:NamedThing posterior lateral line neuromast deposition The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line. got7fsn_ti biological_process owl:Class
GO:0048885 biolink:NamedThing neuromast deposition The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line. got7fsn_ti biological_process owl:Class
GO:0003974 biolink:NamedThing UDP-N-acetylglucosamine 4-epimerase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine. got7fsn_ti UDP-GlcNAc 4-epimerase activity|uridine diphosphoacetylglucosamine epimerase activity|UDP acetylglucosamine epimerase activity|uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity|uridine diphosphate N-acetylglucosamine-4-epimerase activity|UDP-N-acetyl-D-glucosamine 4-epimerase activity RHEA:20517|EC:5.1.3.7|MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN molecular_function owl:Class
GO:0030631 biolink:NamedThing pyrrolysine incorporation The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases. got7fsn_ti lysine methylamine methyltransferase cofactor adduct incorporation|monomethylamine methyltransferase cofactor lysine adduct incorporation RESID:AA0321 biological_process owl:Class
GO:0006451 biolink:NamedThing translational readthrough The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons. got7fsn_ti natural nonsense suppression biological_process owl:Class
GO:0044511 biolink:NamedThing envenomation resulting in modulation of receptor activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism. got7fsn_ti jl 2012-02-26T10:12:24Z biological_process owl:Class
GO:0007291 biolink:NamedThing sperm individualization The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane. got7fsn_ti biological_process owl:Class
GO:0039622 biolink:NamedThing T=16 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres. got7fsn_ti bf 2012-07-18T02:20:23Z VZ:807 cellular_component owl:Class
GO:0106373 biolink:NamedThing 3-deoxyglucosone dehydrogenase activity Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD(+) = 2-dehydro-3-deoxy-D-gluconate + 2 H(+) + NADH. got7fsn_ti hjd 2021-04-12T14:48:12Z molecular_function owl:Class
GO:0048308 biolink:NamedThing organelle inheritance The partitioning of organelles between daughter cells at cell division. got7fsn_ti biological_process owl:Class
GO:0061574 biolink:NamedThing ASAP complex A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1. got7fsn_ti dph 2013-10-08T13:09:16Z cellular_component owl:Class
GO:0097123 biolink:NamedThing cyclin A1-CDK2 complex A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:43:18Z cellular_component owl:Class
GO:0032628 biolink:NamedThing interleukin-24 production The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti MDA7 production|ST16 production|IL-24 production|interleukin-24 secretion|interleukin-24 biosynthetic process GO:0072622|GO:0045524 biological_process owl:Class
GO:0090687 biolink:NamedThing activation of meiosis I spindle assembly checkpoint Any process that starts the inactive process of a meiosis I cell cycle spindle assembly checkpoint. got7fsn_ti tb 2016-07-20T16:49:17Z biological_process owl:Class
GO:1905326 biolink:NamedThing positive regulation of meiosis I spindle assembly checkpoint Any process that activates or increases the frequency, rate or extent of the meiosis I spindle assembly checkpoint. got7fsn_ti upregulation of meiosis I spindle assembly checkpoint|up regulation of meiosis I spindle assembly checkpoint|activation of meiosis I spindle assembly checkpoint|up-regulation of meiosis I spindle assembly checkpoint mah 2016-07-20T12:48:47Z biological_process owl:Class
GO:0070095 biolink:NamedThing fructose-6-phosphate binding Binding to fructose 6-phosphate. got7fsn_ti fructose 6-phosphate binding|D-fructose 6-phosphate binding molecular_function owl:Class
GO:0005729 biolink:NamedThing 2-micrometer circle DNA A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies. got7fsn_ti cellular_component owl:Class
GO:0005727 biolink:NamedThing extrachromosomal circular DNA Circular DNA structures that are not part of a chromosome. got7fsn_ti cellular_component owl:Class
GO:0102966 biolink:NamedThing arachidoyl-CoA:1-dodecanol O-acyltransferase activity Catalysis of the reaction: icosanoyl-CoA + dodecan-1-ol = arachidoyl dodecanoate + coenzyme A. got7fsn_ti EC:2.3.1.75|MetaCyc:RXN-9356 molecular_function owl:Class
GO:0010586 biolink:NamedThing miRNA metabolic process The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression. got7fsn_ti microRNA metabolic process biological_process owl:Class
GO:0051258 biolink:NamedThing protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. got7fsn_ti protein polymer biosynthetic process|protein polymer biosynthesis|protein polymer formation biological_process owl:Class
GO:0140288 biolink:NamedThing GBAF complex A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM. got7fsn_ti pg 2018-11-20T09:13:52Z cellular_component owl:Class
GO:0106336 biolink:NamedThing yolk syncytial layer development The progression of the yolk syncytial layer over time, from its initial formation to the mature structure. The yolk syncytial layer is the peripheral layer of the yolk cell including nuclei and non-yolky cytoplasm. got7fsn_ti YSL development The "yolk syncytial layer" structure can be found in Teleostei, Myxini, Chondrichthyes, Lepisosteiformes and Cephalopoda according. hjd 2020-11-05T17:56:43Z biological_process owl:Class
GO:0035850 biolink:NamedThing epithelial cell differentiation involved in kidney development The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state. got7fsn_ti bf 2011-05-11T11:34:21Z biological_process owl:Class
GO:0002270 biolink:NamedThing plasmacytoid dendritic cell activation A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti biological_process owl:Class
GO:0004663 biolink:NamedThing Rab geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family. got7fsn_ti GGTase-II activity|protein geranylgeranyltransferase type II activity|type II protein geranyl-geranyltransferase activity|geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity|GGTaseII activity|RabGGTase activity|Rab-protein geranylgeranyltransferase activity MetaCyc:2.5.1.60-RXN|MetaCyc:RXN-3701|EC:2.5.1.60 molecular_function owl:Class
GO:0034413 biolink:NamedThing ascospore wall (1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of ascospores. got7fsn_ti ascospore wall beta-1,3-glucan formation|ascospore wall beta-1,3-glucan synthesis|ascospore wall beta-1,3-glucan anabolism|ascospore wall beta-1,3-glucan biosynthesis|ascospore wall 1,3-beta-glucan formation|ascospore wall 1,3-beta-glucan biosynthesis|ascospore wall 1,3-beta-glucan biosynthetic process|ascospore wall 1,3-beta-D-glucan biosynthetic process|ascospore wall 1,3-beta-glucan synthesis|ascospore wall beta-1,3-glucan biosynthetic process|ascospore wall 1,3-beta-glucan anabolism biological_process owl:Class
GO:0071970 biolink:NamedThing fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in fungal cell walls. got7fsn_ti fungal-type cell wall beta-1,3-glucan formation|fungal-type cell wall 1,3-beta-glucan biosynthesis|fungal-type cell wall 1,3-beta-glucan formation|fungal-type cell wall beta-1,3-glucan synthesis|fungal-type cell wall 1,3-beta-glucan anabolism|fungal-type cell wall beta-1,3-glucan anabolism|fungal-type cell wall 1,3-beta-D-glucan biosynthetic process|fungal-type cell wall beta-1,3-glucan biosynthesis|fungal-type cell wall beta-1,3-glucan biosynthetic process|fungal-type cell wall 1,3-beta-glucan synthesis mah 2010-10-18T03:25:56Z biological_process owl:Class
GO:0036457 biolink:NamedThing keratohyalin granule A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope. got7fsn_ti bf 2013-12-09T13:04:09Z cellular_component owl:Class
GO:0097534 biolink:NamedThing lymphoid lineage cell migration The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage. got7fsn_ti lymphoid lineage restricted progenitor cell migration pr 2013-11-28T10:47:15Z biological_process owl:Class
GO:0003135 biolink:NamedThing fibroblast growth factor receptor signaling pathway involved in heart induction The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction. got7fsn_ti fibroblast growth factor receptor signalling pathway involved in heart induction tb 2009-09-22T03:17:49Z biological_process owl:Class
GO:0072524 biolink:NamedThing pyridine-containing compound metabolic process The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. got7fsn_ti pyridine and derivative metabolic process|pyridine-containing compound metabolism mah 2011-01-04T03:21:47Z biological_process owl:Class
GO:0031536 biolink:NamedThing positive regulation of exit from mitosis Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity). got7fsn_ti upregulation of exit from mitosis|up regulation of exit from mitosis|activation of exit from mitosis|up-regulation of exit from mitosis|stimulation of exit from mitosis biological_process owl:Class
GO:0047202 biolink:NamedThing sinapoylglucose-choline O-sinapoyltransferase activity Catalysis of the reaction: 1-O-sinapoyl-beta-D-glucose + choline = O-sinapoylcholine + D-glucose. got7fsn_ti sinapine synthase activity|1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucose:choline 1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)transferase activity RHEA:12024|MetaCyc:2.3.1.91-RXN|KEGG_REACTION:R03075|EC:2.3.1.91 molecular_function owl:Class
GO:0140618 biolink:NamedThing ferric-chelate reductase (NADH) activity Catalysis of the reaction: 2 Fe3+-siderophore + NAD(+) + H(+) -> 2 Fe2+-siderophore + NADH. got7fsn_ti NADH:Fe(3+) oxidoreductase activity|NADH:Fe3+ oxidoreductase activity|iron chelate reductase activity|ferric chelate reductase activity https://github.com/geneontology/go-ontology/issues/21029 pg 2021-03-09T07:20:30Z EC:1.16.1.7|MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN|RHEA:15061 molecular_function owl:Class
GO:0003692 biolink:NamedThing left-handed Z-DNA binding Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags. got7fsn_ti molecular_function owl:Class
GO:0033462 biolink:NamedThing GGC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GGC codon. got7fsn_ti glycine tRNA Note that in the standard genetic code, GGC codes for glycine. molecular_function owl:Class
GO:0062052 biolink:NamedThing starch granule initiation The sequence of events that initiates (or primes) the synthesis of semi-crystalline starch granules within photosynthetic chloroplasts or non-photosynthetic amyloplasts. got7fsn_ti dph 2018-06-08T17:18:57Z biological_process owl:Class
GO:0019252 biolink:NamedThing starch biosynthetic process The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants. got7fsn_ti starch synthesis|starch anabolism|starch biosynthesis|starch formation MetaCyc:PWY-622 biological_process owl:Class
GO:0071713 biolink:NamedThing para-aminobenzoyl-glutamate hydrolase activity Catalysis of the reaction: para-aminobenzoyl-glutamate + H2O = para-aminobenzoate + L-glutamate. got7fsn_ti mah 2010-03-10T01:25:31Z molecular_function owl:Class
GO:0051624 biolink:NamedThing inhibition of norepinephrine uptake Any process that prevents the activation of the directed movement of norepinephrine into a cell. got7fsn_ti inhibition of norepinephrine import|inhibition of noradrenaline uptake|inhibition of levarterenol uptake biological_process owl:Class
GO:0003850 biolink:NamedThing 2-deoxyglucose-6-phosphatase activity Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate. got7fsn_ti 2-deoxyglucose-6-phosphate phosphatase activity|2-deoxy-D-glucose-6-phosphate phosphohydrolase activity KEGG_REACTION:R02587|MetaCyc:3.1.3.68-RXN|EC:3.1.3.68|RHEA:22236 molecular_function owl:Class
GO:0018506 biolink:NamedThing maleylacetate reductase activity Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+. got7fsn_ti maleolylacetate reductase activity|3-oxoadipate:NAD(P)+ oxidoreductase activity UM-BBD_enzymeID:e0063|EC:1.3.1.32|MetaCyc:MALEYLACETATE-REDUCTASE-RXN molecular_function owl:Class
GO:0035523 biolink:NamedThing protein K29-linked deubiquitination A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein. got7fsn_ti protein K29-linked deubiquitinylation|protein K29-linked deubiquitylation bf 2010-05-04T04:33:27Z biological_process owl:Class
GO:0030555 biolink:NamedThing RNA modification guide activity Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0099544 biolink:NamedThing perisynaptic space The extracellular region immediately adjacent to to a synapse. got7fsn_ti extrasynaptic space cellular_component owl:Class
GO:0047732 biolink:NamedThing CDP-abequose epimerase activity Catalysis of the reaction: CDP-3,6-dideoxy-D-glucose = CDP-3,6-dideoxy-D-mannose. got7fsn_ti CDP-3,6-dideoxy-D-glucose 2-epimerase activity|cytidine diphosphoabequose epimerase activity|CDP-D-abequose 2-epimerase activity|CDP-paratose epimerase activity|cytidine diphosphodideoxyglucose epimerase activity|cytidine diphosphate paratose-2-epimerase activity|CDP-tyvelose 2-epimerase activity|CDP-paratose 2-epimerase activity|cytidine diphosphoparatose epimerase activity MetaCyc:RXN-9160|EC:5.1.3.10|RHEA:21656|KEGG_REACTION:R04266 molecular_function owl:Class
GO:0102757 biolink:NamedThing NADPH phosphatase activity Catalysis of the reaction: NADPH + H2O = NADH + hydrogenphosphate. got7fsn_ti MetaCyc:RXN-7703|RHEA:60664 molecular_function owl:Class
GO:0050049 biolink:NamedThing leucine dehydrogenase activity Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH. got7fsn_ti L-leucine:NAD+ oxidoreductase (deaminating)|LeuDH activity|L-leucine dehydrogenase activity|L-leucine:NAD+ oxidoreductase, deaminating MetaCyc:LEUCINE-DEHYDROGENASE-RXN|EC:1.4.1.9|RHEA:12220 molecular_function owl:Class
GO:0047903 biolink:NamedThing fructose 5-dehydrogenase (NADP+) activity Catalysis of the reaction: D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH. got7fsn_ti 5-keto-D-fructose reductase (NADP+)|5-ketofructose reductase (NADP+) activity|5-ketofructose reductase (NADP)|5-ketofructose reductase (NADP(+)) activity|D-fructose:NADP+ 5-oxidoreductase activity|D-(-)fructose:(NADP+) 5-oxidoreductase activity|fructose 5-(nicotinamide adenine dinucleotide phosphate) dehydrogenase activity MetaCyc:FRUCTOSE-5-DEHYDROGENASE-NADP+-RXN|EC:1.1.1.124|RHEA:14069 molecular_function owl:Class
GO:0051508 biolink:NamedThing stigmasterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol. got7fsn_ti MetaCyc:RXN-12126|RHEA:61828 molecular_function owl:Class
GO:0044832 biolink:NamedThing induction by virus of host cytokine production The process in which a virus increases the frequency, rate or extent of cytokine production in its host organism. got7fsn_ti positive regulation by virus of host cytokine production jl 2014-02-06T13:04:23Z biological_process owl:Class
GO:0001819 biolink:NamedThing positive regulation of cytokine production Any process that activates or increases the frequency, rate or extent of production of a cytokine. got7fsn_ti upregulation of cytokine production|stimulation of cytokine production|activation of cytokine production|positive regulation of cytokine secretion|up-regulation of cytokine production|positive regulation of cytokine biosynthetic process|up regulation of cytokine production GO:0050715|GO:0042108 biological_process owl:Class
GO:0044410 biolink:NamedThing entry into host through natural portals Penetration by a symbiont into a host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti entry into other organism through natural portals during symbiotic interaction|entry into other organism through natural portals involved in symbiotic interaction GO:0051829 biological_process owl:Class
GO:0061694 biolink:NamedThing alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity. got7fsn_ti An example of this complex is PhnI (P16687) in Escherichia coli. dph 2015-05-06T10:12:02Z cellular_component owl:Class
GO:0061695 biolink:NamedThing transferase complex, transferring phosphorus-containing groups A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). got7fsn_ti dph 2015-05-06T11:22:38Z cellular_component owl:Class
GO:0061540 biolink:NamedThing octopamine secretion, neurotransmission The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter. got7fsn_ti dph 2013-06-21T16:24:47Z biological_process owl:Class
GO:0008802 biolink:NamedThing betaine-aldehyde dehydrogenase activity Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+. got7fsn_ti betaine aldehyde oxidase activity|BetB|betaine aldehyde dehydrogenase activity|betaine-aldehyde:NAD+ oxidoreductase activity|BADH activity EC:1.2.1.8|RHEA:15305|Reactome:R-HSA-6797955|MetaCyc:BADH-RXN molecular_function owl:Class
GO:0000341 biolink:NamedThing RNA trimethylguanosine cap binding Binding to the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans. got7fsn_ti RNA m2,2,7G cap binding molecular_function owl:Class
GO:0061517 biolink:NamedThing macrophage proliferation The expansion of a macrophage population by cell division. got7fsn_ti dph 2013-04-18T13:17:56Z biological_process owl:Class
GO:0048384 biolink:NamedThing retinoic acid receptor signaling pathway The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. got7fsn_ti retinoic acid receptor signalling pathway|RAR signaling pathway biological_process owl:Class
GO:0006231 biolink:NamedThing dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). got7fsn_ti dTMP formation|dTMP anabolism|dTMP biosynthesis|dTMP synthesis biological_process owl:Class
GO:0080002 biolink:NamedThing UDP-glucose:4-aminobenzoate acylglucosyltransferase activity Catalysis of the reaction: 4-aminobenzoate + UDP-glucose = p-aminobenzoate-beta-D-glucopyranosyl ester + UDP. got7fsn_ti UDP-glucose:p-aminobenzoate glucosyltransferase activity|UDP-glucose:p-aminobenzoate acylglucosyltransferase activity|UDP-glucose:pABA acylglucosyltransferase activity MetaCyc:RXN-6142 molecular_function owl:Class
GO:1900698 biolink:NamedThing regulation of o-orsellinic acid biosynthetic process Any process that modulates the frequency, rate or extent of o-orsellinic acid biosynthetic process. got7fsn_ti regulation of o-orsellinic acid biosynthesis|regulation of o-orsellinic acid synthesis|regulation of o-orsellinic acid formation|regulation of o-orsellinic acid anabolism di 2012-05-22T04:56:46Z biological_process owl:Class
GO:0047507 biolink:NamedThing (deoxy)nucleoside-phosphate kinase activity Catalysis of the reaction: ATP + deoxynucleoside phosphate = ADP + deoxynucleoside diphosphate. got7fsn_ti deoxynucleoside-5'-monophosphate kinase activity|deoxyribonucleoside monophosphokinase activity|ATP:deoxynucleoside-phosphate phosphotransferase activity|deoxynucleoside monophosphate kinase activity MetaCyc:DEOXYNUCLEOSIDE-PHOSPHATE-KINASE-RXN|RHEA:11216|EC:2.7.4.13 molecular_function owl:Class
GO:0048577 biolink:NamedThing negative regulation of short-day photoperiodism, flowering Any process that stops, prevents or reduces short-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. got7fsn_ti downregulation of short-day photoperiodism, flowering|down regulation of short-day photoperiodism, flowering|down-regulation of short-day photoperiodism, flowering|inhibition of short-day photoperiodism, flowering biological_process owl:Class
GO:0033870 biolink:NamedThing thiol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + a thiol = adenosine 3',5'-bisphosphate + an S-alkyl thiosulfate. got7fsn_ti adenosine 3'-phosphate 5'-sulphatophosphate sulfotransferase activity|PAPS sulfotransferase activity|3'-phosphoadenylyl-sulfate:thiol S-sulfotransferase activity EC:2.8.2.16|MetaCyc:THIOL-SULFOTRANSFERASE-RXN|RHEA:14637 molecular_function owl:Class
GO:0019231 biolink:NamedThing perception of static position The perception of the orientation of different parts of the body with respect to one another. got7fsn_ti biological_process owl:Class
GO:0061665 biolink:NamedThing SUMO ligase activity Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S --> X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T14:00:44Z molecular_function owl:Class
GO:0120066 biolink:NamedThing pyloric canal smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal part of the pylorus between the pyloric antrum and the pyloric sphincter. got7fsn_ti krc 2017-06-13T22:37:51Z biological_process owl:Class
GO:0120064 biolink:NamedThing stomach pylorus smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the most distal part of the stomach. got7fsn_ti krc 2017-06-13T22:32:04Z biological_process owl:Class
GO:0046174 biolink:NamedThing polyol catabolic process The chemical reactions and pathways resulting in the breakdown of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. got7fsn_ti polyol degradation|polyol catabolism|polyol breakdown|polyhydric alcohol catabolic process biological_process owl:Class
GO:0015987 biolink:NamedThing GTP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis. got7fsn_ti biological_process owl:Class
GO:0042279 biolink:NamedThing nitrite reductase (cytochrome, ammonia-forming) activity Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+. got7fsn_ti cytochrome c552 activity|ammonia:ferricytochrome-c oxidoreductase activity|cytochrome c nitrite reductase activity|multiheme nitrite reductase activity|nitrite reductase (cytochrome; ammonia-forming) RHEA:13089|Wikipedia:Cytochrome_c_nitrite_reductase|EC:1.7.2.2|MetaCyc:1.7.2.2-RXN molecular_function owl:Class
GO:0051639 biolink:NamedThing actin filament network formation The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments. got7fsn_ti actin gel biosynthesis|actin gel formation biological_process owl:Class
GO:0034606 biolink:NamedThing response to hermaphrodite contact The response by the male to a hermaphrodite after initial contact following mate finding. The male stops forward locomotion, presses the ventral side of his tail against his partner's body, and begins moving backward along the hermaphrodite. Male response behavior is initiated when sensory neurons located in the rays of his tail contact a potential mate. got7fsn_ti biological_process owl:Class
GO:0010306 biolink:NamedThing rhamnogalacturonan II biosynthetic process The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms. got7fsn_ti biological_process owl:Class
GO:0089714 biolink:NamedThing UDP-N-acetyl-D-mannosamine dehydrogenase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+. got7fsn_ti EC:1.1.1.336|RHEA:25780 molecular_function owl:Class
GO:0070573 biolink:NamedThing metallodipeptidase activity Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. got7fsn_ti metalloexodipeptidase activity|metallo-exo-dipeptidase activity mah 2009-04-15T03:11:29Z Reactome:R-HSA-2065355|Reactome:R-HSA-2022398|Reactome:R-HSA-2022405 molecular_function owl:Class
GO:0016805 biolink:NamedThing dipeptidase activity Catalysis of the hydrolysis of a dipeptide. got7fsn_ti cytosolic dipeptidase activity GO:0102008 Reactome:R-HSA-266012|MetaCyc:3.4.13.18-RXN|EC:3.4.13.21|Reactome:R-HSA-9026771|EC:3.4.13.-|Reactome:R-HSA-5693783|Reactome:R-HSA-5433067|MetaCyc:3.4.13.21-RXN|EC:3.4.13.18 molecular_function owl:Class
GO:0047783 biolink:NamedThing corticosterone 18-monooxygenase activity Catalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O. got7fsn_ti corticosterone 18-hydroxylase activity|corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)|corticosterone methyl oxidase activity MetaCyc:CORTICOSTERONE-18-MONOOXYGENASE-RXN|RHEA:11872|EC:1.14.15.5 molecular_function owl:Class
GO:0035038 biolink:NamedThing female pronucleus assembly Assembly of the haploid nucleus of the unfertilized egg. got7fsn_ti female pronucleus assembly biological_process owl:Class
GO:0018565 biolink:NamedThing dihydroxydibenzothiophene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0162 molecular_function owl:Class
GO:0031749 biolink:NamedThing D2 dopamine receptor binding Binding to a D2 dopamine receptor. got7fsn_ti D2 dopamine receptor ligand molecular_function owl:Class
GO:0043262 biolink:NamedThing adenosine-diphosphatase activity Catalysis of the reaction: ADP + H2O = AMP + phosphate. got7fsn_ti ATP-diphosphatase activity|ADPase|adenosine diphosphatase activity|ATP diphosphohydrolase activity|ADPase activity RHEA:61436|MetaCyc:APYRASE-RXN molecular_function owl:Class
GO:0097611 biolink:NamedThing dinoflagellate cingulum A cell surface furrow that wraps around a dinoflagellate cell; the transverse flagellum lies in it. got7fsn_ti cingulum|transverse groove|girdle The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. pr 2014-06-09T11:28:22Z cellular_component owl:Class
GO:0034987 biolink:NamedThing immunoglobulin receptor binding Binding to one or more specific sites on an immunoglobulin receptor molecule. got7fsn_ti Fc receptor binding molecular_function owl:Class
GO:0072599 biolink:NamedThing establishment of protein localization to endoplasmic reticulum The directed movement of a protein to a specific location in the endoplasmic reticulum. got7fsn_ti establishment of protein localisation to endoplasmic reticulum|establishment of protein localization to ER|establishment of protein localization in endoplasmic reticulum|establishment of protein localisation to ER mah 2011-02-14T02:23:41Z biological_process owl:Class
GO:0003871 biolink:NamedThing 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. got7fsn_ti 5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity|methionine synthase (cobalamin-independent) activity|MetE|cobalamin-independent methionine synthase activity|tetrahydropteroylglutamate-homocysteine transmethylase activity|methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity|homocysteine methylase activity|methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity|tetrahydropteroyltriglutamate methyltransferase activity MetaCyc:HOMOCYSMET-RXN|RHEA:21196|KEGG_REACTION:R04405|EC:2.1.1.14 molecular_function owl:Class
GO:0051996 biolink:NamedThing squalene synthase activity Catalysis of the reaction: presqualene diphosphate + NADPH = squalene + NADP+ + diphosphate. got7fsn_ti squalene synthetase activity Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. ai 2010-07-16T05:10:24Z MetaCyc:RXN66-281|EC:2.5.1.21 molecular_function owl:Class
GO:0047720 biolink:NamedThing indoleacetaldoxime dehydratase activity Catalysis of the reaction: (indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H(2)O. got7fsn_ti (indol-3-yl)acetaldehyde-oxime hydro-lyase activity|indoleacetaldoxime hydro-lyase activity|3-indoleacetaldoxime hydro-lyase activity|(indol-3-yl)acetaldehyde-oxime hydro-lyase [(indol-3-yl)acetonitrile-forming]|indole-3-acetaldoxime hydro-lyase activity|indole-3-acetaldehyde-oxime hydro-lyase activity RHEA:23156|KEGG_REACTION:R04093|MetaCyc:RXN-1403|EC:4.99.1.6 molecular_function owl:Class
GO:0060925 biolink:NamedThing ventricular cardiac muscle cell fate commitment The commitment of cells to ventricular cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the ventricle. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. got7fsn_ti ventricular cardiomyocyte cell fate commitment|ventricular heart muscle cell fate commitment dph 2009-09-29T11:49:39Z biological_process owl:Class
GO:0018145 biolink:NamedThing protein-DNA covalent cross-linking via peptidyl-serine The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine. got7fsn_ti DNA-protein covalent cross-linking via peptidyl-serine RESID:AA0246 biological_process owl:Class
GO:0038127 biolink:NamedThing ERBB signaling pathway A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti ErbB signaling|EGFR family signaling pathway|ERBB signalling pathway|EGF receptor family signaling pathway bf 2012-03-30T09:23:01Z biological_process owl:Class
GO:0061577 biolink:NamedThing calcium ion transmembrane transport via high voltage-gated calcium channel A process in which a calcium ion is transported from one side of a membrane to the other by means of a high voltage-gated calcium channel. got7fsn_ti generation of L-type calcium current dph 2013-11-15T16:20:27Z biological_process owl:Class
GO:0034242 biolink:NamedThing negative regulation of syncytium formation by plasma membrane fusion Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. got7fsn_ti biological_process owl:Class
GO:0008118 biolink:NamedThing N-acetyllactosaminide alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein. got7fsn_ti alpha2->3 sialyltransferase activity|cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity|SiaT|CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity EC:2.4.99.6|RHEA:52316|MetaCyc:2.4.99.6-RXN molecular_function owl:Class
GO:0008213 biolink:NamedThing protein alkylation The addition of an alkyl group to a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom. got7fsn_ti protein amino acid alkylation biological_process owl:Class
GO:0090685 biolink:NamedThing RNA localization to nucleus A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus. got7fsn_ti RNA localisation to nucleus tb 2016-07-19T17:00:49Z biological_process owl:Class
GO:0035669 biolink:NamedThing TRAM-dependent toll-like receptor 4 signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response. got7fsn_ti TRAM-dependent toll-like receptor 4 signalling pathway|TRAM-dependent TLR4 signaling pathway bf 2011-02-01T02:41:09Z biological_process owl:Class
GO:0097498 biolink:NamedThing endothelial tube lumen extension Any endothelial tube morphogenesis process by which the tube is increased in length. got7fsn_ti pr 2013-08-12T13:49:54Z biological_process owl:Class
GO:0004492 biolink:NamedThing methylmalonyl-CoA decarboxylase activity Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2. got7fsn_ti methylmalonyl-coenzyme A decarboxylase activity|(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)|(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity|(S)-methylmalonyl-CoA carboxy-lyase activity EC:7.2.4.3|RHEA:21396|MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN molecular_function owl:Class
GO:0016618 biolink:NamedThing hydroxypyruvate reductase activity Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+. got7fsn_ti D-glycerate dehydrogenase activity|beta-hydroxypyruvate reductase activity|D-glycerate:NADP+ 2-oxidoreductase activity|NADH:hydroxypyruvate reductase activity MetaCyc:RXN0-300|RHEA:18657|MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN|EC:1.1.1.81 molecular_function owl:Class
GO:0047962 biolink:NamedThing glycine N-benzoyltransferase activity Catalysis of the reaction: benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+). got7fsn_ti benzoyl-CoA:glycine N-acyltransferase activity|benzoyl CoA-amino acid N-acyltransferase activity|benzoyl-CoA:glycine N-benzoyltransferase activity KEGG_REACTION:R02452|RHEA:18493|Reactome:R-HSA-159574|MetaCyc:GLYCINE-N-BENZOYLTRANSFERASE-RXN|EC:2.3.1.71|Reactome:R-HSA-159566 molecular_function owl:Class
GO:0019160 biolink:NamedThing NMN nucleosidase activity Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide. got7fsn_ti nicotinamide-nucleotide phosphoribohydrolase activity|NMN glycohydrolase activity|nicotinamide mononucleotide nucleosidase activity|NMNase activity|nicotinamide mononucleotidase activity|NMNGhase activity MetaCyc:NMNNUCLEOSID-RXN|EC:3.2.2.14|RHEA:23140|KEGG_REACTION:R01270 molecular_function owl:Class
GO:0061266 biolink:NamedThing mesonephric interstitial fibroblast differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the mesonephros as it progresses from its formation to the mature state. got7fsn_ti mesonephros interstitial cell differentiation dph 2010-08-30T03:12:17Z biological_process owl:Class
GO:0097347 biolink:NamedThing TAM protein secretion complex A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane. got7fsn_ti translocation and assembly module protein complex pr 2012-06-21T10:44:15Z cellular_component owl:Class
GO:0052700 biolink:NamedThing ergothioneine catabolic process The chemical reactions and pathways resulting in the breakdown of ergothioneine, a naturally occurring metabolite of histidine with antioxidant properties. got7fsn_ti ergothioneine breakdown|2-mercaptoergothioneine trimethylbetaine breakdown|2-mercaptoergothioneine trimethylbetaine catabolic process|(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate catabolic process|2-mercaptoergothioneine trimethylbetaine catabolism|ergothioneine catabolism|ergothioneine degradation|2-mercaptoergothioneine trimethylbetaine degradation ai 2011-08-01T03:56:22Z biological_process owl:Class
GO:0071098 biolink:NamedThing alpha6-beta4 integrin-Fyn complex A protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn. got7fsn_ti ITGA6-ITGB4-FYN complex mah 2009-11-06T04:52:10Z cellular_component owl:Class
GO:0009859 biolink:NamedThing pollen hydration The process in which water is taken up by pollen. got7fsn_ti biological_process owl:Class
GO:0042978 biolink:NamedThing ornithine decarboxylase activator activity Binds to and increases ornithine decarboxylase activity. got7fsn_ti L-ornithine carboxy-lyase activator activity molecular_function owl:Class
GO:0042979 biolink:NamedThing ornithine decarboxylase regulator activity Binds to and modulates the activity of the enzyme ornithine decarboxylase. got7fsn_ti molecular_function owl:Class
GO:0051016 biolink:NamedThing barbed-end actin filament capping The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. got7fsn_ti plus-end actin filament capping activity|barbed-end actin capping activity|plus-end F-actin capping activity|barbed-end F-actin capping activity biological_process owl:Class
GO:0051693 biolink:NamedThing actin filament capping The binding of a protein or protein complex to the end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. got7fsn_ti actin capping activity|F-actin capping activity biological_process owl:Class
GO:0006788 biolink:NamedThing heme oxidation The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme. got7fsn_ti haem oxidation biological_process owl:Class
GO:0042168 biolink:NamedThing heme metabolic process The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. got7fsn_ti haem metabolism|haem metabolic process|heme metabolism biological_process owl:Class
GO:0033414 biolink:NamedThing UGC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UGC codon. got7fsn_ti TGC codon-amino acid adaptor activity|cysteine tRNA Note that in the standard genetic code, TGC codes for cysteine. molecular_function owl:Class
GO:0045726 biolink:NamedThing positive regulation of integrin biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. got7fsn_ti positive regulation of integrin formation|positive regulation of integrin biosynthesis|activation of integrin biosynthetic process|positive regulation of integrin synthesis|upregulation of integrin biosynthetic process|stimulation of integrin biosynthetic process|positive regulation of integrin anabolism|up-regulation of integrin biosynthetic process|up regulation of integrin biosynthetic process biological_process owl:Class
GO:0019357 biolink:NamedThing nicotinate nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid). got7fsn_ti nicotinate nucleotide synthesis|nicotinate nucleotide formation|nicotinate nucleotide anabolism|nicotinate nucleotide biosynthesis biological_process owl:Class
GO:0046980 biolink:NamedThing tapasin binding Binding to tapasin, a member of the MHC class I loading complex which bridges the TAP peptide transporter to class I molecules. got7fsn_ti TAPBP binding|TAP binding protein binding molecular_function owl:Class
GO:0043890 biolink:NamedThing N-acetylgalactosamine-6-sulfatase activity Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. got7fsn_ti chondroitinase|acetylgalactosamine 6-sulfatase activity|galactose-6-sulfate sulfatase activity|N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity|N-acetylgalactosamine 6-sulfatase activity|chondroitin sulfatase|chondroitinsulfatase|N-acetylgalactosamine-6-sulfate sulfatase activity Reactome:R-HSA-1630304|Reactome:R-HSA-2263490|MetaCyc:3.1.6.4-RXN|EC:3.1.6.4 molecular_function owl:Class
GO:1990867 biolink:NamedThing response to gastrin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus. got7fsn_ti sl 2015-09-25T16:22:39Z biological_process owl:Class
GO:1900793 biolink:NamedThing shamixanthone biosynthetic process The chemical reactions and pathways resulting in the formation of shamixanthone. got7fsn_ti shamixanthone synthesis|shamixanthone biosynthesis|shamixanthone formation|shamixanthone anabolism di 2012-06-04T09:40:49Z biological_process owl:Class
GO:0010243 biolink:NamedThing response to organonitrogen compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. got7fsn_ti response to organic nitrogen biological_process owl:Class
GO:0003865 biolink:NamedThing 3-oxo-5-alpha-steroid 4-dehydrogenase activity Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. got7fsn_ti 3-oxosteroid delta4-dehydrogenase|3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity|testosterone 5alpha-reductase|steroid delta4-5alpha-reductase activity|delta4-3-keto steroid 5alpha-reductase activity|steroid 5-alpha-reductase activity|steroid 5alpha-reductase|delta4-3-oxo steroid reductase activity|3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity|5alpha-reductase|delta4-5alpha-dehydrogenase activity|3-keto-delta4-steroid-5alpha-reductase activity|delta4-3-ketosteroid5alpha-oxidoreductase activity|steroid 5 alpha reductase|delta4-3-oxosteroid-5alpha-reductase|4-ene-3-ketosteroid-5alpha-oxidoreductase activity|3-oxo-5alpha-steroid delta4-dehydrogenase activity|3-oxo-5alpha-steroid 4-dehydrogenase activity MetaCyc:1.3.99.5-RXN|Reactome:R-HSA-9705714|Reactome:R-HSA-9705713|EC:1.3.99.5|Reactome:R-HSA-469659 molecular_function owl:Class
GO:0003774 biolink:NamedThing cytoskeletal motor activity Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). got7fsn_ti motor activity https://github.com/geneontology/go-ontology/issues/21756|https://github.com/geneontology/go-ontology/issues/19590 Reactome:R-HSA-1861595 molecular_function owl:Class
GO:0071121 biolink:NamedThing alpha9-beta1 integrin-VEGF-D complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor D. got7fsn_ti ITGA9-ITGB1-FIGF complex mah 2009-11-13T02:21:37Z cellular_component owl:Class
GO:0050038 biolink:NamedThing L-xylulose reductase (NADP+) activity Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH. got7fsn_ti L-xylulose reductase activity EC:1.1.1.10|KEGG_REACTION:R01904|RHEA:17025|MetaCyc:L-XYLULOSE-REDUCTASE-RXN|Reactome:R-HSA-5662851|Reactome:R-HSA-5661240 molecular_function owl:Class
GO:0061985 biolink:NamedThing carbon catabolite repression A process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of the metabolism of other carbon sources. got7fsn_ti dph 2018-02-15T16:49:48Z biological_process owl:Class
GO:0070818 biolink:NamedThing protoporphyrinogen oxidase activity Catalysis of the reaction: protoporphyrinogen IX + acceptor = protoporphyrin IX + reduced acceptor. got7fsn_ti protoporphyrinogen-IX oxidase activity|protoporphyrinogen IX oxidase activity|protoporphyrinogenase activity mah 2009-07-20T02:41:12Z molecular_function owl:Class
GO:1990620 biolink:NamedThing ANPR-A receptor complex A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. got7fsn_ti NPR1 receptor complex An example of this is Npr1 in rat (UniProt symbol P18910) in PMID:15117952 (inferred from direct assay). ame 2015-01-28T16:03:22Z cellular_component owl:Class
GO:0007561 biolink:NamedThing imaginal disc eversion The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis. got7fsn_ti biological_process owl:Class
GO:0031477 biolink:NamedThing myosin VII complex A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain. got7fsn_ti cellular_component owl:Class
GO:0033906 biolink:NamedThing hyaluronoglucuronidase activity Catalysis of the random hydrolysis of 1,3-linkages between beta-D-glucuronate and N-acetyl-D-glucosamine residues in hyaluronate. got7fsn_ti hyaluronate 3-glycanohydrolase activity|orgelase activity|glucuronoglucosaminoglycan hyaluronate lyase activity|hyaluronidase activity EC:3.2.1.36|MetaCyc:3.2.1.36-RXN molecular_function owl:Class
GO:0021701 biolink:NamedThing cerebellar Golgi cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0043468 biolink:NamedThing regulation of fucose catabolic process Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose. got7fsn_ti biological_process owl:Class
GO:1990460 biolink:NamedThing leptin receptor binding Binding to a leptin receptor. got7fsn_ti tb 2014-08-18T20:17:43Z molecular_function owl:Class
GO:0003054 biolink:NamedThing circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours. got7fsn_ti master pacemaker clock regulation of blood pressure|SCN regulation of blood pressure biological_process owl:Class
GO:0000002 biolink:NamedThing mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. got7fsn_ti biological_process owl:Class
GO:0070005 biolink:NamedThing cysteine-type aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 EC:3.4.18.- molecular_function owl:Class
GO:0008062 biolink:NamedThing eclosion rhythm The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn. got7fsn_ti biological_process owl:Class
GO:0031534 biolink:NamedThing minus-end directed microtubule sliding The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules. got7fsn_ti biological_process owl:Class
GO:0032978 biolink:NamedThing protein insertion into membrane from inner side The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side. got7fsn_ti insertion of proteins into membrane from the inner side biological_process owl:Class
GO:0019615 biolink:NamedThing catechol catabolic process, ortho-cleavage The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups. got7fsn_ti catechol degradation, ortho-cleavage|catechol breakdown, ortho-cleavage MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY biological_process owl:Class
GO:0002263 biolink:NamedThing cell activation involved in immune response A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. got7fsn_ti cell activation during immune response biological_process owl:Class
GO:0008819 biolink:NamedThing cobinamide kinase activity Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate. got7fsn_ti molecular_function owl:Class
GO:0031610 biolink:NamedThing nuclear proteasome regulatory particle, base subcomplex The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell. got7fsn_ti cellular_component owl:Class
GO:1900570 biolink:NamedThing diorcinol metabolic process The chemical reactions and pathways involving diorcinol. got7fsn_ti diorcinol metabolism di 2012-05-15T06:35:01Z biological_process owl:Class
GO:0018782 biolink:NamedThing cis-chloroacrylic acid dehalogenase activity Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde. got7fsn_ti UM-BBD_reactionID:r0688 molecular_function owl:Class
GO:0047923 biolink:NamedThing gentisate decarboxylase activity Catalysis of the reaction: 2,5-dihydroxybenzoate + H(+) = CO(2) + hydroquinone. got7fsn_ti 2,5-dihydroxybenzoate carboxy-lyase (hydroquinone-forming)|gentisate carboxy-lyase activity|2,5-dihydroxybenzoate decarboxylase activity KEGG_REACTION:R02489|RHEA:21312|MetaCyc:GENTISATE-DECARBOXYLASE-RXN|EC:4.1.1.62 molecular_function owl:Class
GO:1990131 biolink:NamedThing Gtr1-Gtr2 GTPase complex A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins. got7fsn_ti rb 2013-06-25T20:39:16Z cellular_component owl:Class
GO:0030789 biolink:NamedThing precorrin-3B C17-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4. got7fsn_ti precorrin-3 methyltransferase activity|CobJ|precorrin-3 methylase activity|S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity MetaCyc:2.1.1.131-RXN|EC:2.1.1.131|RHEA:12761 molecular_function owl:Class
GO:0044078 biolink:NamedThing positive regulation by symbiont of host receptor-mediated endocytosis Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism. got7fsn_ti positive regulation of host receptor-mediated endocytosis by symbiont biological_process owl:Class
GO:0048260 biolink:NamedThing positive regulation of receptor-mediated endocytosis Any process that activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. got7fsn_ti activation of receptor mediated endocytosis|stimulation of receptor mediated endocytosis|up regulation of receptor mediated endocytosis|positive regulation of receptor mediated endocytosis|upregulation of receptor mediated endocytosis|up-regulation of receptor mediated endocytosis biological_process owl:Class
GO:0120211 biolink:NamedThing proacrosomal vesicle fusion Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome. got7fsn_ti krc 2019-05-22T17:12:55Z biological_process owl:Class
GO:0050538 biolink:NamedThing N-carbamoyl-L-amino-acid hydrolase activity Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate. got7fsn_ti L-carbamoylase activity|N-carbamoyl-L-amino acid amidohydrolase activity EC:3.5.1.87|RHEA:17581|MetaCyc:3.5.1.87-RXN molecular_function owl:Class
GO:0036250 biolink:NamedThing peroxisome transport along microtubule The directed movement of a peroxisome along a microtubule, mediated by motor proteins. got7fsn_ti bf 2012-05-31T03:09:09Z biological_process owl:Class
GO:0019492 biolink:NamedThing proline salvage Any process which produces the amino acid proline from derivatives of it, without de novo synthesis. got7fsn_ti proline cycling biological_process owl:Class
GO:0043723 biolink:NamedThing 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia. got7fsn_ti DRAP deaminase activity|2,5-diamino-6-(5-phosphoribitylamino)pyrimidin-4(3H)-one deaminase activity GO:0017173 MetaCyc:RXN-10058 molecular_function owl:Class
GO:0047823 biolink:NamedThing D-glutamyltransferase activity Catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide. got7fsn_ti D-glutamyl transpeptidase activity|D-gamma-glutamyl transpeptidase activity|glutamine:D-glutamyl-peptide 5-glutamyltransferase activity RHEA:35623|EC:2.3.2.1|MetaCyc:D-GLUTAMYLTRANSFERASE-RXN molecular_function owl:Class
GO:0032629 biolink:NamedThing interleukin-25 production The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-25 anabolism|interleukin-25 biosynthesis|IL-25 production|IL-25 secretion|interleukin-25 formation|interleukin-25 synthesis|interleukin-25 biosynthetic process|IL17E secretion|interleukin-25 secretion GO:0045525|GO:0072623 biological_process owl:Class
GO:0047002 biolink:NamedThing L-arabinitol 2-dehydrogenase activity Catalysis of the reaction: L-arabinitol + NAD(+) = L-ribulose + H(+) + NADH. got7fsn_ti L-arabinitol 2-dehydrogenase (ribulose forming) activity EC:1.1.1.13|RHEA:21356|MetaCyc:1.1.1.13-RXN|KEGG_REACTION:R02441 molecular_function owl:Class
GO:0046729 biolink:NamedThing viral procapsid A stable empty viral capsid produced during the assembly of viruses. got7fsn_ti cellular_component owl:Class
GO:0071794 biolink:NamedThing CAP-Gly domain binding Binding to a CAP-Gly domain of a protein. The CAP_Gly domain is a conserved, glycine-rich domain of about 42 residues found in some cytoskeleton-associated proteins, and features a novel protein fold containing three beta-sheets. got7fsn_ti mah 2010-09-02T02:02:53Z molecular_function owl:Class
GO:0060957 biolink:NamedThing endocardial cell fate commitment The commitment of a cell to an endocardial cell fate and its capacity to differentiate into an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. got7fsn_ti dph 2009-09-29T03:24:29Z biological_process owl:Class
GO:1902584 biolink:NamedThing positive regulation of response to water deprivation Any process that activates or increases the frequency, rate or extent of response to water deprivation. got7fsn_ti activation of response to thirst|up-regulation of response to drought|activation of drought tolerance|up regulation of drought tolerance|activation of response to water deprivation|positive regulation of response to drought|up-regulation of response to dehydration|activation of response to dehydration|upregulation of response to drought|up-regulation of drought tolerance|up-regulation of response to thirst|up-regulation of response to water deprivation|upregulation of drought tolerance|positive regulation of response to dehydration|up regulation of response to thirst|positive regulation of response to thirst|upregulation of response to water deprivation|upregulation of response to thirst|up regulation of response to drought|activation of response to drought|positive regulation of drought tolerance|up regulation of response to dehydration|upregulation of response to dehydration|up regulation of response to water deprivation tb 2013-12-19T00:31:58Z biological_process owl:Class
GO:2000070 biolink:NamedThing regulation of response to water deprivation Any process that modulates the frequency, rate or extent of response to water deprivation. got7fsn_ti regulation of drought tolerance|regulation of response to drought|regulation of response to thirst|regulation of response to dehydration tb 2010-08-23T11:32:32Z biological_process owl:Class
GO:0047013 biolink:NamedThing cholate 12-alpha dehydrogenase activity Catalysis of the reaction: cholate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH. got7fsn_ti 12alpha-hydroxysteroid dehydrogenase activity|12alpha-hydroxysteroid:NADP+ 12-oxidoreductase activity|NADP-12alpha-hydroxysteroid dehydrogenase activity|NAD-dependent 12alpha-hydroxysteroid dehydrogenase activity|12-alpha-hydroxysteroid dehydrogenase activity|12alpha-hydroxy steroid dehydrogenase activity MetaCyc:1.1.1.176-RXN|KEGG_REACTION:R02793|EC:1.1.1.176|RHEA:14129 molecular_function owl:Class
GO:0061473 biolink:NamedThing murein tripeptide carboxypeptidase activity Catalysis of the reaction L-Ala-gamma-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-gamma-D-Glu + meso-diaminopimelate. got7fsn_ti dph 2012-11-06T12:23:39Z molecular_function owl:Class
GO:2001004 biolink:NamedThing negative regulation of pectin catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of pectin catabolic process. got7fsn_ti negative regulation of pectin degradation|negative regulation of pectin catabolism|negative regulation of pectin breakdown tt 2011-08-08T03:24:06Z biological_process owl:Class
GO:0021621 biolink:NamedThing hypoglossal nerve structural organization The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. got7fsn_ti CN XII structural organization|hypoglossal nerve structural organisation biological_process owl:Class
GO:0019304 biolink:NamedThing anaerobic rhamnose catabolic process The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen. got7fsn_ti anaerobic rhamnose breakdown|anaerobic rhamnose degradation|anaerobic rhamnose catabolism biological_process owl:Class
GO:0019301 biolink:NamedThing rhamnose catabolic process The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. got7fsn_ti rhamnose degradation|rhamnose catabolism|rhamnose breakdown MetaCyc:RHAMCAT-PWY biological_process owl:Class
GO:0047792 biolink:NamedThing cyanohydrin beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + (S)-4-hydroxymandelonitrile = UDP + (S)-4-hydroxy-mandelonitrile beta-D-glucoside. got7fsn_ti uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase activity|UDP-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity|UDP-D-glucose:(S)-4-hydroxymandelonitrile beta-D-glucosyltransferase activity|uridine diphosphoglucose-cyanohydrin glucosyltransferase activity|UGT85B1 activity|UDP-glucose-p-hydroxymandelonitrile glucosyltransferase activity|cyanohydrin b-glucosyltransferase activity|UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase activity|uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase activity EC:2.4.1.85|RHEA:12853 molecular_function owl:Class
GO:0035914 biolink:NamedThing skeletal muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle. got7fsn_ti bf 2011-06-24T02:36:19Z biological_process owl:Class
PATO:0000001 biolink:NamedThing got7fsn_ti owl:Class
BFO:0000020 biolink:NamedThing got7fsn_ti owl:Class
GO:0031169 biolink:NamedThing ferrichrome biosynthetic process The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. got7fsn_ti ferrichrome anabolism|ferrichrome synthesis|ferrichrome biosynthetic process, peptide modification|ferrichrome formation|ferrichrome biosynthetic process, peptide formation|ferrichrome biosynthesis GO:0031199|GO:0031200 biological_process owl:Class
GO:0019539 biolink:NamedThing hydroxymate-containing siderophore biosynthetic process The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid. Hydroxamate is one of the three major chemical groups incorporated into siderophore structures with catechol and a-hydroxycarboxylate, each having a high selectivity for iron(3+). got7fsn_ti https://github.com/geneontology/go-ontology/issues/20975 GO:0031198|GO:0031197 biological_process owl:Class
GO:0097309 biolink:NamedThing cap1 mRNA methylation Methylation of the ribose of the first nucleotide of a 5'-capped mRNA. got7fsn_ti cap1 mRNA capping pr 2012-05-23T04:03:13Z biological_process owl:Class
GO:0050092 biolink:NamedThing meso-tartrate dehydrogenase activity Catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH. got7fsn_ti meso-tartrate:NAD+ oxidoreductase activity MetaCyc:MESO-TARTRATE-DEHYDROGENASE-RXN|KEGG_REACTION:R02544|EC:1.3.1.7|RHEA:18553 molecular_function owl:Class
GO:0031601 biolink:NamedThing nuclear proteasome core complex The core complex of a proteasome located in the nucleus of a cell. got7fsn_ti cellular_component owl:Class
GO:0102676 biolink:NamedThing avenasterol-desaturase activity Catalysis of the reaction: avenasterol + O2 + NADPH + H+ <=> 5-dehydroavenasterol + 2 H2O + NADP. got7fsn_ti MetaCyc:RXN-4209 molecular_function owl:Class
GO:0102722 biolink:NamedThing gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent Catalysis of the reaction: 4-hydroxybutyrate + NAD(P) = 4-oxobutanoate + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-6903 molecular_function owl:Class
GO:0034057 biolink:NamedThing RNA strand-exchange activity Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity. got7fsn_ti molecular_function owl:Class
GO:0090601 biolink:NamedThing enucleation The process in which nucleated precursor cells lose their nucleus. got7fsn_ti tb 2014-09-05T16:25:16Z biological_process owl:Class
GO:0061628 biolink:NamedThing H3K27me3 modified histone binding Binding to a histone H3 in which the lysine residue at position 27 has been modified by trimethylation. got7fsn_ti H3-K27me3 modified histone binding dph 2014-05-14T15:36:53Z molecular_function owl:Class
GO:0045722 biolink:NamedThing positive regulation of gluconeogenesis Any process that activates or increases the frequency, rate or extent of gluconeogenesis. got7fsn_ti upregulation of gluconeogenesis|stimulation of gluconeogenesis|activation of gluconeogenesis|up regulation of gluconeogenesis|up-regulation of gluconeogenesis biological_process owl:Class
GO:0019170 biolink:NamedThing methylglyoxal reductase (NADH-dependent) activity Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+. got7fsn_ti methylglyoxal reductase activity|D-lactaldehyde dehydrogenase activity|(R)-lactaldehyde:NAD+ oxidoreductase activity EC:1.1.1.78|MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN|RHEA:24528 molecular_function owl:Class
GO:0047373 biolink:NamedThing acetoxybutynylbithiophene deacetylase activity Catalysis of the reaction: 5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(4-hydroxy-but-1-ynyl)-2,2'-bithiophene + acetate + H(+). got7fsn_ti 5-(4-acetoxy-1-butynyl)-2,2'-bithiophene:acetate esterase activity|5-(4-acetoxybut-1-ynyl)-2,2'-bithiophene O-acetylhydrolase activity|acetoxybutynylbithiophene esterase activity RHEA:11548|EC:3.1.1.54|KEGG_REACTION:R04490|MetaCyc:3.1.1.54-RXN molecular_function owl:Class
GO:0010422 biolink:NamedThing regulation of brassinosteroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids. got7fsn_ti biological_process owl:Class
GO:0039720 biolink:NamedThing virogenic stroma A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled. got7fsn_ti VS bf 2013-12-19T15:45:32Z cellular_component owl:Class
GO:0103080 biolink:NamedThing methylthiopropylmalate isomerase activity Catalysis of the reaction: 2-(3-methylthiopropyl)malate(2-) <=> 3-(3'-methylthio)propylmalate. got7fsn_ti RHEA:50644|MetaCyc:RXNQT-4164 molecular_function owl:Class
GO:0009035 biolink:NamedThing type I site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions, driven by ATP hydrolysis. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA. got7fsn_ti ATP-dependent DNase activity|deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)|deoxyribonuclease (adenosine triphosphate-hydrolyzing)|adenosine triphosphate-dependent deoxyribonuclease activity|type I restriction enzyme activity|type I site-specific deoxyribonuclease activity https://github.com/geneontology/go-ontology/issues/21612 EC:3.1.21.3|MetaCyc:3.1.21.3-RXN molecular_function owl:Class
GO:1904090 biolink:NamedThing peptidase inhibitor complex A protein complex which is capable of peptidase inhibitor activity. got7fsn_ti Cathepsin-B - cystatin-A complex An example of this is Cystatin-A in human (UniProt symbol P01040) in PMID:20860624 (inferred from physical interaction). bhm 2015-03-26T10:16:27Z cellular_component owl:Class
GO:0018110 biolink:NamedThing histone arginine kinase activity Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+). got7fsn_ti histone-arginine kinase activity EC:2.7.3.- molecular_function owl:Class
GO:0102856 biolink:NamedThing 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8323|EC:1.14.19.25 molecular_function owl:Class
GO:0030417 biolink:NamedThing nicotianamine metabolic process The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. got7fsn_ti nicotianamine metabolism biological_process owl:Class
GO:0043759 biolink:NamedThing methylbutanoate-CoA ligase activity Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = AMP + diphosphate + 2-methylbutanoyl-CoA. got7fsn_ti branched chain acyl-CoA synthetase (ADP-forming) activity|branched chain acyl CoA synthetase (ADP-forming) activity|branched-chain acyl-CoA synthetase (ADP-forming) activity|branched-chain acyl CoA synthetase (ADP-forming) activity https://github.com/geneontology/go-ontology/issues/18967 RHEA:46180 molecular_function owl:Class
GO:1900810 biolink:NamedThing helvolic acid metabolic process The chemical reactions and pathways involving helvolic acid. got7fsn_ti Fumigacin metabolic process|Fumigacin metabolism|helvolic acid metabolism di 2012-06-04T10:02:28Z biological_process owl:Class
GO:0008396 biolink:NamedThing oxysterol 7-alpha-hydroxylase activity Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O. got7fsn_ti cytochrome P450 CYP7B1 Reactome:R-HSA-191972|Reactome:R-HSA-192178|Reactome:R-HSA-192065|Reactome:R-HSA-5602885 molecular_function owl:Class
GO:0033839 biolink:NamedThing flavonol-3-O-glycoside glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside. got7fsn_ti UDP-glucose:flavonol-3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside 2'''-O-beta-D-glucosyltransferase activity RHEA:23544|MetaCyc:2.4.1.240-RXN|EC:2.4.1.240 molecular_function owl:Class
GO:0036089 biolink:NamedThing cleavage furrow formation Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell. got7fsn_ti cleavage furrow positioning Consider also annotating to 'establishment of contractile ring localization involved in cell cycle cytokinesis ; GO:0032188'. bf 2012-01-10T02:41:03Z biological_process owl:Class
GO:0046101 biolink:NamedThing hypoxanthine biosynthetic process The chemical reactions and pathways resulting in the formation of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate. got7fsn_ti hypoxanthine biosynthesis|hypoxanthine formation|hypoxanthine anabolism|hypoxanthine synthesis biological_process owl:Class
GO:0018610 biolink:NamedThing dibenzofuran 4,4a-dioxygenase activity Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+. got7fsn_ti MetaCyc:R606-RXN|UM-BBD_enzymeID:e0030|RHEA:42460 molecular_function owl:Class
GO:0075197 biolink:NamedThing haustorium neck formation The assembly by the symbiont of a neck-like structure for the purpose of penetration into its host organism. The neck-like structure connects haustorium mother cell and haustorium. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti symbiont haustorium neck formation for entry into host|formation of symbiont haustorium neck for entry into host https://github.com/geneontology/go-ontology/issues/18557 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0032295 biolink:NamedThing ensheathment of neuronal cell bodies The process in which satellite glial cells isolate neuronal cell bodies. got7fsn_ti biological_process owl:Class
GO:0047259 biolink:NamedThing glucomannan 4-beta-mannosyltransferase activity Catalysis of the reaction: glucomannan(n) + GDP-mannose = glucomannan(n+1) + GDP. got7fsn_ti GDP-man-beta-mannan mannosyltransferase activity|glucomannan-synthase activity|GDP-mannose:glucomannan 1,4-beta-D-mannosyltransferase activity|glucomannan 4-b-mannosyltransferase activity EC:2.4.1.32|MetaCyc:2.4.1.32-RXN molecular_function owl:Class
GO:0061811 biolink:NamedThing ADP-ribosyl cyclase activity Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide. got7fsn_ti dph 2016-11-11T13:25:18Z molecular_function owl:Class
GO:0035346 biolink:NamedThing positive regulation of hypoxanthine transport Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti positive regulation of 6-hydroxypurine transport bf 2010-03-04T10:42:48Z biological_process owl:Class
GO:0140604 biolink:NamedThing mycofactocin biosynthetic process The chemical reactions and pathways resulting in the formation of the coenzyme mycofactocin, a variably glycosylated small molecule electron pair carrier derived from the C-terminal valine-tyrosine dipeptide of the ribosomally translated precursor peptide MftA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20547 pg 2021-02-16T07:42:51Z biological_process owl:Class
GO:0005822 biolink:NamedThing inner plaque of spindle pole body One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus. got7fsn_ti cellular_component owl:Class
GO:0006542 biolink:NamedThing glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. got7fsn_ti glutamine anabolism|glutamine biosynthesis|glutamine synthesis|glutamine formation MetaCyc:GLNSYN-PWY biological_process owl:Class
GO:2000061 biolink:NamedThing regulation of ureter smooth muscle cell differentiation Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation. got7fsn_ti jl 2010-08-20T01:44:16Z biological_process owl:Class
GO:0048634 biolink:NamedThing regulation of muscle organ development Any process that modulates the frequency, rate or extent of muscle development. got7fsn_ti biological_process owl:Class
GO:0018422 biolink:NamedThing GDP-mannose:serine-protein mannose-1-phosphotransferase activity Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein. got7fsn_ti molecular_function owl:Class
GO:0102193 biolink:NamedThing protein-ribulosamine 3-kinase activity Catalysis of the reaction: ATP + a [protein]-N6-D-ribulosyl-L-lysine <=> ADP + a [protein]-N6-(3-O-phospho-D-ribulosyl)-L-lysine. got7fsn_ti MetaCyc:RXN-12003|EC:2.7.1.172|RHEA:48432 molecular_function owl:Class
GO:0055074 biolink:NamedThing calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. got7fsn_ti regulation of calcium ion concentration biological_process owl:Class
GO:0071496 biolink:NamedThing cellular response to external stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. mah 2009-12-18T02:36:52Z biological_process owl:Class
GO:0035798 biolink:NamedThing 2-alkenal reductase (NADP+) activity Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+. got7fsn_ti NADPH:2-alkenal alpha,beta-hydrogenase activity bf 2011-04-14T01:11:07Z molecular_function owl:Class
GO:0032440 biolink:NamedThing 2-alkenal reductase [NAD(P)+] activity Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+. got7fsn_ti n-alkanal:NAD(P)+ 2-oxidoreductase activity|NAD(P)H-dependent alkenal/one oxidoreductase activity EC:1.3.1.74 molecular_function owl:Class
GO:0102250 biolink:NamedThing linear malto-oligosaccharide phosphorylase activity Catalysis of the reaction: hydrogenphosphate + a linear malto-oligosaccharide = alpha-D-glucose 1-phosphate + a linear malto-oligosaccharide. got7fsn_ti MetaCyc:RXN-12392|EC:2.4.1.1 molecular_function owl:Class
GO:0097018 biolink:NamedThing renal albumin absorption A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. got7fsn_ti pr 2011-03-23T03:15:04Z biological_process owl:Class
GO:0097017 biolink:NamedThing renal protein absorption A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686). got7fsn_ti pr 2011-03-23T03:13:04Z biological_process owl:Class
GO:0102950 biolink:NamedThing indole-3-acetyl-valine synthetase activity Catalysis of the reaction: indole-3-acetate + L-valine + ATP = H+ + indole-3-acetyl-valine + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-9083 molecular_function owl:Class
GO:0045237 biolink:NamedThing CXCR1 chemokine receptor binding Binding to a CXCR1 chemokine receptor. got7fsn_ti CXCR1 chemokine receptor ligand molecular_function owl:Class
GO:0097045 biolink:NamedThing phosphatidylserine exposure on blood platelet A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system. got7fsn_ti pr 2011-04-20T12:54:35Z biological_process owl:Class
GO:0005142 biolink:NamedThing interleukin-11 receptor binding Binding to an interleukin-11 receptor. got7fsn_ti IL-11|interleukin-11 receptor ligand molecular_function owl:Class
GO:0002089 biolink:NamedThing lens morphogenesis in camera-type eye The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. got7fsn_ti lens morphogenesis|lens morphogenesis in camera-style eye biological_process owl:Class
GO:0004677 biolink:NamedThing DNA-dependent protein kinase activity DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. got7fsn_ti This reaction requires the presence of DNA. molecular_function owl:Class
GO:0047558 biolink:NamedThing 3-cyanoalanine hydratase activity Catalysis of the reaction: L-asparagine = 3-cyano-L-alanine + H(2)O + H(+). got7fsn_ti L-asparagine hydro-lyase activity|beta-cyanoalanine hydratase activity|beta-cyanoalanine hydrolase activity|beta-CNAla hydrolase activity|beta-CNA nitrilase activity|L-asparagine hydro-lyase (3-cyanoalanine-forming) RHEA:15385|KEGG_REACTION:R01267|EC:4.2.1.65|MetaCyc:3-CYANOALANINE-HYDRATASE-RXN molecular_function owl:Class
GO:0030708 biolink:NamedThing germarium-derived female germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0006037 biolink:NamedThing cell wall chitin metabolic process The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. got7fsn_ti cell wall chitin metabolism biological_process owl:Class
GO:1990304 biolink:NamedThing MUB1-RAD6-UBR2 ubiquitin ligase complex A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme. got7fsn_ti This complex has been identified in Saccharomyces cerevisiae (UniProt symbol P19812) - see PMID:18070918. bhm 2014-03-03T21:54:21Z cellular_component owl:Class
GO:0010487 biolink:NamedThing thermospermine synthase activity Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+. got7fsn_ti EC:2.5.1.79|RHEA:30515|MetaCyc:RXN-11190 molecular_function owl:Class
GO:0010446 biolink:NamedThing response to alkaline pH Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti response to basic pH|response to alkalinity biological_process owl:Class
GO:0021502 biolink:NamedThing neural fold elevation formation The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm. got7fsn_ti biological_process owl:Class
GO:0032274 biolink:NamedThing gonadotropin secretion The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone. got7fsn_ti gonadotrophin secretion biological_process owl:Class
GO:0031873 biolink:NamedThing type 2 proteinase activated receptor binding Binding to a type 2 proteinase activated receptor. got7fsn_ti type 2 proteinase activated receptor ligand molecular_function owl:Class
GO:0010420 biolink:NamedThing 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+. got7fsn_ti polyprenyldihydroxybenzoate methyltransferase activity sl 2015-10-28T22:12:58Z GO:1990886 MetaCyc:RXN-9281|RHEA:44452|EC:2.1.1.114 molecular_function owl:Class
GO:0030352 biolink:NamedThing inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. got7fsn_ti molecular_function owl:Class
GO:0004850 biolink:NamedThing uridine phosphorylase activity Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. got7fsn_ti uridine:phosphate alpha-D-ribosyltransferase activity|UrdPase activity|UPase activity|UPH|pyrimidine phosphorylase activity Reactome:R-HSA-74372|RHEA:24388|MetaCyc:URPHOS-RXN|Reactome:R-HSA-74376|EC:2.4.2.3 molecular_function owl:Class
GO:0098544 biolink:NamedThing maintenance of protein complex location Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away. got7fsn_ti dos 2013-11-15T18:20:16Z biological_process owl:Class
GO:0015171 biolink:NamedThing amino acid transmembrane transporter activity Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. got7fsn_ti amino acid/choline transmembrane transporter activity|general amino acid permease activity|amino acid permease activity|amino acid transporter activity|hydroxy/aromatic amino acid permease activity GO:0015359 Reactome:R-HSA-375473|Reactome:R-HSA-379426|Reactome:R-HSA-379415|Reactome:R-HSA-375405|Reactome:R-HSA-352347|Reactome:R-HSA-8952726|Reactome:R-HSA-352354|Reactome:R-HSA-376200|Reactome:R-HSA-352119|Reactome:R-HSA-352103|Reactome:R-HSA-5659734|Reactome:R-HSA-352371|Reactome:R-HSA-5660694|Reactome:R-HSA-5660890|Reactome:R-HSA-5659674|Reactome:R-HSA-212642|Reactome:R-HSA-352174|Reactome:R-HSA-888592|Reactome:R-HSA-375417|Reactome:R-HSA-5659755|Reactome:R-HSA-378513|Reactome:R-HSA-352136|Reactome:R-HSA-352385|Reactome:R-HSA-352379|Reactome:R-HSA-5655702|Reactome:R-HSA-352107|Reactome:R-HSA-352029|Reactome:R-HSA-375790|Reactome:R-HSA-5660910|Reactome:R-HSA-375487|Reactome:R-HSA-5653850|Reactome:R-HSA-379432|Reactome:R-HSA-375768|Reactome:R-HSA-352232|Reactome:R-HSA-352108|Reactome:R-HSA-352059|Reactome:R-HSA-352364|Reactome:R-HSA-375770|Reactome:R-HSA-351963|Reactome:R-HSA-375776|Reactome:R-HSA-352158|Reactome:R-HSA-351987|Reactome:R-HSA-352052|Reactome:R-HSA-352191|Reactome:R-HSA-352182|Reactome:R-HSA-210439 molecular_function owl:Class
GO:0030729 biolink:NamedThing acetoacetate-CoA ligase activity Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+). got7fsn_ti acetoacetyl-CoA synthetase activity|acetoacetate:CoA ligase (AMP-forming) KEGG_REACTION:R01357|RHEA:16117|Reactome:R-HSA-5694494|EC:6.2.1.16|MetaCyc:ACETOACETATE--COA-LIGASE-RXN molecular_function owl:Class
GO:0018550 biolink:NamedThing tetrachloro-p-hydroquinone reductive dehalogenase activity Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl. got7fsn_ti tetrachlorohydroquinone reductive dehalogenase activity UM-BBD_reactionID:r0314|EC:1.8.99.- molecular_function owl:Class
GO:0008366 biolink:NamedThing axon ensheathment Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal. got7fsn_ti nerve ensheathment|cellular axon ensheathment|cellular nerve ensheathment GO:0042553 biological_process owl:Class
GO:0090380 biolink:NamedThing seed trichome maturation A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state. got7fsn_ti These processes continue to 60 DPA in Gossypium spp. tb 2010-09-15T02:29:42Z biological_process owl:Class
GO:0048530 biolink:NamedThing fruit morphogenesis The process in which the anatomical structures of a fruit are generated and organized. A fruit is a reproductive body of a seed plant. got7fsn_ti biological_process owl:Class
GO:0005113 biolink:NamedThing patched binding Binding to a patched (ptc) protein, a receptor for hedgehog proteins. got7fsn_ti ptc binding|ptc ligand|patched ligand molecular_function owl:Class
GO:0030219 biolink:NamedThing megakaryocyte differentiation The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte. got7fsn_ti megakaryocyte cell differentiation biological_process owl:Class
GO:0005742 biolink:NamedThing mitochondrial outer membrane translocase complex A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments. got7fsn_ti mitochondrion outer membrane translocase complex|GIP complex cellular_component owl:Class
GO:0007168 biolink:NamedThing receptor guanylyl cyclase signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti receptor guanylyl cyclase signalling pathway biological_process owl:Class
GO:0016751 biolink:NamedThing S-succinyltransferase activity Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0016748 biolink:NamedThing succinyltransferase activity Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0019114 biolink:NamedThing catechol dioxygenase activity Catalysis of the reaction: catechol + O2 = a muconate. got7fsn_ti EC:1.13.11.- molecular_function owl:Class
GO:0090583 biolink:NamedThing protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0070695 biolink:NamedThing FHF complex A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex). got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. mah 2009-06-04T03:17:29Z cellular_component owl:Class
GO:0070594 biolink:NamedThing juvenile hormone response element binding Binding to a juvenile hormone response element (JHRE), a conserved sequence found in the promoters of genes whose expression is regulated in response to juvenile hormone. got7fsn_ti JHRE binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. mah 2009-04-28T03:31:27Z molecular_function owl:Class
GO:0036505 biolink:NamedThing prosaposin receptor activity Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D). got7fsn_ti prosaposin-activated receptor activity bf 2015-06-11T10:13:10Z molecular_function owl:Class
GO:0051956 biolink:NamedThing negative regulation of amino acid transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti inhibition of amino acid transport|negative regulation of amino acid transmembrane transport|down-regulation of amino acid transport|downregulation of amino acid transport|down regulation of amino acid transport biological_process owl:Class
GO:0102956 biolink:NamedThing UDP-glucose:sinapaldehyde 4-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + sinapoyl aldehyde = H+ + sinapaldehyde glucoside + UDP. got7fsn_ti MetaCyc:RXN-92|RHEA:57712 molecular_function owl:Class
GO:0032406 biolink:NamedThing MutLbeta complex binding Binding to a MutLbeta mismatch repair complex. got7fsn_ti molecular_function owl:Class
GO:0032404 biolink:NamedThing mismatch repair complex binding Binding to a mismatch repair complex. got7fsn_ti molecular_function owl:Class
GO:0033622 biolink:NamedThing integrin activation The aggregation, arrangement and bonding together of an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits, that lead to the increased affinity of the integrin for its extracellular ligands. got7fsn_ti integrin complex activation|integrin complex assembly biological_process owl:Class
GO:0018048 biolink:NamedThing C-terminal peptidyl-proline amidation The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0095 biological_process owl:Class
GO:0043004 biolink:NamedThing cytoplasmic sequestering of CFTR protein The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane. got7fsn_ti cytoplasmic storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein|retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm|sequestering of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm|sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein) in cytoplasm|cytoplasmic sequestration of CFTR (cystic fibrosis transmembrane conductance regulator protein)|storage of CFTR (cystic fibrosis transmembrane conductance regulator) protein in cytoplasm|cytoplasmic sequestering of cystic fibrosis transmembrane conductance regulator protein|cytoplasmic retention of CFTR (cystic fibrosis transmembrane conductance regulator) protein|maintenance of CFTR protein location in cytoplasm biological_process owl:Class
GO:0043002 biolink:NamedThing negative regulation of Golgi to plasma membrane CFTR protein transport Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. got7fsn_ti down-regulation of Golgi to plasma membrane CFTR protein transport|down regulation of Golgi to plasma membrane CFTR protein transport|downregulation of Golgi to plasma membrane CFTR protein transport|inhibition of Golgi to plasma membrane CFTR protein transport biological_process owl:Class
GO:0050250 biolink:NamedThing retinal oxidase activity Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2. got7fsn_ti retinene oxidase activity|retinal:oxygen oxidoreductase activity EC:1.2.3.11|RHEA:22520|MetaCyc:RETINAL-OXIDASE-RXN molecular_function owl:Class
GO:1990878 biolink:NamedThing cellular response to gastrin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus. got7fsn_ti sl 2015-10-07T17:38:14Z biological_process owl:Class
GO:0032637 biolink:NamedThing interleukin-8 production The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-8 secretion|IL-8 production|interleukin-8 biosynthetic process GO:0072606|GO:0042228 biological_process owl:Class
GO:0047870 biolink:NamedThing discadenine synthase activity Catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H(+). got7fsn_ti S-adenosyl-L-methionine:6-N-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferase activity|S-adenosyl-L-methionine:N6-(Delta2-isopentenyl)-adenine 3-(3-amino-3-carboxypropyl)-transferas|discadenine synthetase activity KEGG_REACTION:R03726|MetaCyc:DISCADENINE-SYNTHASE-RXN|RHEA:19581|EC:2.5.1.24 molecular_function owl:Class
GO:0002100 biolink:NamedThing tRNA wobble adenosine to inosine editing The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine. got7fsn_ti biological_process owl:Class
GO:0007624 biolink:NamedThing ultradian rhythm The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours. got7fsn_ti biological_process owl:Class
GO:0060606 biolink:NamedThing tube closure Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold. got7fsn_ti dph 2009-05-15T09:44:07Z biological_process owl:Class
GO:0036261 biolink:NamedThing 7-methylguanosine cap hypermethylation Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation. got7fsn_ti snoRNA capping|TMG cap formation|m(7)G cap hypermethylation|hypermethylation of snoRNA cap|snRNA capping|hypermethylation of snRNA cap|2,2,7-trimethylguanosine cap formation|conversion of m(7)G to m(3)G bf 2012-06-15T02:21:39Z biological_process owl:Class
GO:0014055 biolink:NamedThing acetylcholine secretion, neurotransmission The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS). got7fsn_ti biological_process owl:Class
GO:0006586 biolink:NamedThing indolalkylamine metabolic process The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. got7fsn_ti indolamine metabolic process|indolamine metabolism|indolalkylamine metabolism biological_process owl:Class
GO:0018789 biolink:NamedThing cyclamate sulfohydrolase activity Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate. got7fsn_ti cyclamate sulphohydrolase activity|cyclamate sulfamidase activity|cyclohexylsulfamate sulfamidase activity|cyclamate sulfamatase activity|cyclohexylsulfamate sulfohydrolase activity UM-BBD_reactionID:r0755|RHEA:18481|MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN|EC:3.10.1.2|KEGG_REACTION:R02564 molecular_function owl:Class
GO:0016826 biolink:NamedThing hydrolase activity, acting on acid sulfur-nitrogen bonds Catalysis of the hydrolysis of any acid sulfur-nitrogen bond. got7fsn_ti hydrolase activity, acting on acid sulphur-nitrogen bonds EC:3.10.-.- molecular_function owl:Class
GO:0045257 biolink:NamedThing succinate dehydrogenase complex (ubiquinone) The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration. got7fsn_ti cellular_component owl:Class
GO:0150076 biolink:NamedThing neuroinflammatory response The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents. got7fsn_ti neural tissue inflammatory response|nerve tissue inflammatory response|nervous tissue inflammatory response bc 2018-07-26T12:25:34Z biological_process owl:Class
GO:0071756 biolink:NamedThing pentameric IgM immunoglobulin complex A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide. got7fsn_ti pentameric IgM antibody Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0071518 biolink:NamedThing autoinducer-2 kinase activity Catalysis of the reaction: 4,5-dihydroxy-pentane-2,3-dione + ATP = 5-phospho-4-hydroxy-pentane-2,3-dione (P-DPD) + ADP. got7fsn_ti 4,5-dihydroxy-pentane-2,3-dione kinase activity mah 2010-01-06T05:08:17Z RHEA:15377|MetaCyc:RXN0-5461 molecular_function owl:Class
GO:0047466 biolink:NamedThing 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase activity Catalysis of the reaction: cis-2-chloro-4-carboxymethylenebut-2-en-1,4-olide = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide. got7fsn_ti 2-chlorocarboxymethylenebutenolide isomerase activity|chlorodienelactone isomerase activity|2-chloro-4-carboxymethylenebut-2-en-1,4-olide cis-trans-isomerase activity GO:0018840 KEGG_REACTION:R04576|MetaCyc:5.2.1.10-RXN|EC:5.2.1.10|UM-BBD_reactionID:r0278|RHEA:10924 molecular_function owl:Class
GO:0052738 biolink:NamedThing oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a quinone or similar compound. got7fsn_ti EC:1.2.5.- molecular_function owl:Class
GO:0042056 biolink:NamedThing chemoattractant activity Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. got7fsn_ti attractant molecular_function owl:Class
GO:0019559 biolink:NamedThing histidine catabolic process to imidazol-5-yl-lactate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate. got7fsn_ti histidine breakdown to imidazol-5-yl-lactate|histidine degradation to imidazol-5-yl-lactate MetaCyc:HISTDEG-PWY biological_process owl:Class
GO:0006548 biolink:NamedThing histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. got7fsn_ti histidine breakdown|histidine catabolism|histidine degradation biological_process owl:Class
GO:0070368 biolink:NamedThing positive regulation of hepatocyte differentiation Any process that activates or increases the rate or extent of hepatocyte differentiation. got7fsn_ti stimulation of hepatocyte differentiation|upregulation of hepatocyte differentiation|activation of hepatocyte differentiation|up-regulation of hepatocyte differentiation|positive regulation of liver cell differentiation|up regulation of hepatocyte differentiation biological_process owl:Class
GO:0070991 biolink:NamedThing medium-chain-acyl-CoA dehydrogenase activity Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12. got7fsn_ti MCAD activity mah 2009-10-29T04:11:49Z EC:1.3.99.- molecular_function owl:Class
GO:1990322 biolink:NamedThing collagen type XXIII trimer A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane. got7fsn_ti bhm 2014-03-14T22:01:00Z cellular_component owl:Class
GO:0047183 biolink:NamedThing anthocyanin 5-aromatic acyltransferase activity Catalysis of the reaction: anthocyanidin-3,5-diglucoside + hydroxycinnamoyl-CoA = anthocyanidin 3-glucoside-5-hydroxycinnamoylglucoside + CoA. got7fsn_ti hydroxycinnamoyl-CoA:anthocyanidin 3,5-diglucoside 5-O-glucoside-6'''-O-hydroxycinnamoyltransferase activity MetaCyc:RXN-7945|EC:2.3.1.153|RHEA:15661 molecular_function owl:Class
GO:0006295 biolink:NamedThing nucleotide-excision repair, DNA incision, 3'-to lesion The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage. got7fsn_ti nucleotide-excision repair, DNA incision, 3' to lesion biological_process owl:Class
GO:0033683 biolink:NamedThing nucleotide-excision repair, DNA incision A process that results in the endonucleolytic cleavage of the damaged strand of DNA. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. got7fsn_ti nucleic acid cleavage involved in nucleotide-excision repair|DNA incision involved in nucleotide-excision repair biological_process owl:Class
GO:0000132 biolink:NamedThing establishment of mitotic spindle orientation A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures. got7fsn_ti orienting of mitotic spindle|establishment of spindle orientation during mitosis|establishment of spindle orientation involved in mitotic cell cycle|mitotic spindle orientation GO:0030607|GO:0030609 biological_process owl:Class
GO:0034803 biolink:NamedThing 3-hydroxy-2-naphthoate 2,3-dioxygenase activity Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate. got7fsn_ti UM-BBD_reactionID:r1104|EC:1.13.11.- molecular_function owl:Class
GO:0018622 biolink:NamedThing 4-chlorophenylacetate 3,4-dioxygenase activity Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+). got7fsn_ti 4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating) KEGG_REACTION:R03306|RHEA:14689|MetaCyc:1.14.12.9-RXN|UM-BBD_reactionID:r0308|EC:1.14.12.9 molecular_function owl:Class
GO:0012511 biolink:NamedThing monolayer-surrounded lipid storage body A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins. got7fsn_ti oilbody|oleosome|oil body|spherosome GO:0009520 Wikipedia:Oil_body cellular_component owl:Class
GO:0035539 biolink:NamedThing 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. got7fsn_ti 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase activity|8-oxo-7,8-dihydrodeoxyguanosine triphosphatase activity|8-oxo-7,8-dihydro-deoxyguanosine triphosphate pyrophosphatase activity|8-oxo-dGTPase activity|8-oxo-dGTP pyrophosphohydrolase activity bf 2010-05-07T10:54:19Z EC:3.6.1.55|Reactome:R-HSA-2395849|RHEA:31575|Reactome:R-HSA-2395869 molecular_function owl:Class
GO:0032840 biolink:NamedThing intramolecular proline-rich ligand binding Binding to a proline-rich region within the same polypeptide. got7fsn_ti intramolecular proline-rich region binding molecular_function owl:Class
GO:0043621 biolink:NamedThing protein self-association Binding to a domain within the same polypeptide. got7fsn_ti protein self association|intramolecular protein binding|protein self binding molecular_function owl:Class
GO:0047602 biolink:NamedThing acetoacetate decarboxylase activity Catalysis of the reaction: acetoacetate + H(+) = acetone + CO(2). got7fsn_ti acetoacetate carboxy-lyase (acetone-forming)|acetoacetate carboxy-lyase activity|acetoacetic acid decarboxylase activity RHEA:19729|EC:4.1.1.4|KEGG_REACTION:R01366|MetaCyc:ACETOACETATE-DECARBOXYLASE-RXN molecular_function owl:Class
GO:0008899 biolink:NamedThing homoserine O-succinyltransferase activity Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA. got7fsn_ti homoserine O-transsuccinylase activity|homoserine succinyltransferase activity|succinyl-CoA:L-homoserine O-succinyltransferase activity RHEA:22008|KEGG_REACTION:R01777|MetaCyc:HOMSUCTRAN-RXN|EC:2.3.1.46 molecular_function owl:Class
GO:0035692 biolink:NamedThing macrophage migration inhibitory factor receptor complex A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins. got7fsn_ti bf 2011-02-25T11:33:15Z cellular_component owl:Class
GO:0042582 biolink:NamedThing azurophil granule Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. got7fsn_ti primary granule cellular_component owl:Class
GO:0010620 biolink:NamedThing negative regulation of transcription by transcription factor catabolism Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. got7fsn_ti biological_process owl:Class
GO:0047840 biolink:NamedThing dCTP diphosphatase activity Catalysis of the reaction: dCTP + H2O = dCMP + diphosphate. got7fsn_ti deoxycytidine-triphosphatase activity|dCTP nucleotidohydrolase activity|dCTPase activity|dCTP pyrophosphatase activity|deoxycytidine triphosphatase activity|deoxy-CTPase activity MetaCyc:DCTP-PYROPHOSPHATASE-RXN|RHEA:22636|EC:3.6.1.12|Reactome:R-HSA-6786257 molecular_function owl:Class
GO:0002099 biolink:NamedThing tRNA wobble guanine modification The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified. got7fsn_ti biological_process owl:Class
GO:0003878 biolink:NamedThing ATP citrate synthase activity Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA. got7fsn_ti ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)|citric cleavage enzyme activity|ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity|ATP-citric lyase activity|acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)|ATP-citrate (pro-S)-lyase activity|acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]|ATP-citrate (pro-S-)-lyase activity|citrate-ATP lyase activity|citrate cleavage enzyme activity|acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity|ATP citrate (pro-S)-lyase activity|adenosine triphosphate citrate lyase activity Note that this function was formerly EC:4.1.3.8. GO:0046913 MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN|EC:2.3.3.8|MetaCyc:PWY-5172|KEGG_REACTION:R00352|RHEA:21160|Reactome:R-HSA-75848 molecular_function owl:Class
GO:0043408 biolink:NamedThing regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade. got7fsn_ti regulation of mitogen activated protein kinase cascade|regulation of mitogen-activated protein kinase cascade|regulation of mitogen activated protein kinase kinase kinase cascade|regulation of mitogen-activated protein kinase kinase kinase cascade|regulation of MAP kinase kinase kinase cascade|regulation of MAP kinase cascade|regulation of MAPKKK cascade biological_process owl:Class
GO:0052586 biolink:NamedThing oxidoreductase activity, acting on other nitrogenous compounds as donors, with a quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a quinone or similar compound. got7fsn_ti ai 2010-08-13T10:34:37Z EC:1.7.5.- molecular_function owl:Class
GO:0018533 biolink:NamedThing peptidyl-cysteine acetylation The acetylation of peptidyl-cysteine. got7fsn_ti biological_process owl:Class
GO:0030413 biolink:NamedThing competence pheromone activity A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence. got7fsn_ti molecular_function owl:Class
GO:0034834 biolink:NamedThing 2-mercaptobenzothiazole dioxygenase activity Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol. got7fsn_ti UM-BBD_reactionID:r1177|EC:1.13.11.- molecular_function owl:Class
GO:0034863 biolink:NamedThing 2,4,4-trimethyl-1-pentanol dehydrogenase activity Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1270 molecular_function owl:Class
GO:0003691 biolink:NamedThing double-stranded telomeric DNA binding Binding to double-stranded telomere-associated DNA. got7fsn_ti molecular_function owl:Class
GO:0060531 biolink:NamedThing neuroendocrine cell differentiation involved in prostate gland acinus development The process in which relatively unspecialized cells acquires specialized structural and functions of a neuroendocrine cell of the prostate gland acinus. got7fsn_ti biological_process owl:Class
GO:0099192 biolink:NamedThing cerebellar Golgi cell to granule cell synapse A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell. got7fsn_ti dos 2017-12-20T16:12:25Z cellular_component owl:Class
GO:0022617 biolink:NamedThing extracellular matrix disassembly A process that results in the breakdown of the extracellular matrix. got7fsn_ti biological_process owl:Class
GO:0003286 biolink:NamedThing atrial septum intermedium development The progression of the atrial septum intermedium over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-20T10:23:52Z biological_process owl:Class
GO:0042740 biolink:NamedThing exogenous antibiotic catabolic process The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism. got7fsn_ti exogenous antibiotic breakdown|exogenous antibiotic degradation|exogenous antibiotic catabolism biological_process owl:Class
GO:0044789 biolink:NamedThing modulation by host of viral release from host cell A process in which a host organism modulates the frequency, rate or extent of the release of a virus with which it is infected, from its cells. got7fsn_ti jl 2013-06-06T10:51:10Z biological_process owl:Class
GO:1902186 biolink:NamedThing regulation of viral release from host cell Any process that modulates the frequency, rate or extent of viral release from host cell. got7fsn_ti regulation of viral exit|regulation of viral shedding|regulation of release of virus from host|regulation of viral release ss 2013-06-04T03:54:03Z biological_process owl:Class
GO:0099138 biolink:NamedThing altruistic, chimeric sorocarp development Development of a chimeric sorocarp in which cells of all genotypes have an equal chance of becoming a spore cell. got7fsn_ti fully co-operative, chimeric sorocarp development biological_process owl:Class
GO:0033659 biolink:NamedThing modification by symbiont of host mitochondrion The process in which an organism effects a change in the structure or function of host cell mitochondria. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0034991 biolink:NamedThing nuclear meiotic cohesin complex A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. got7fsn_ti cellular_component owl:Class
GO:0030893 biolink:NamedThing meiotic cohesin complex A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex. got7fsn_ti cellular_component owl:Class
GO:0030771 biolink:NamedThing N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+). got7fsn_ti N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity|benzoyl-CoA:anthranilate N-benzoyltransferase|S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity KEGG_REACTION:R04421|MetaCyc:2.1.1.105-RXN|EC:2.1.1.105|RHEA:17405 molecular_function owl:Class
GO:0008927 biolink:NamedThing mannonate dehydratase activity Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. got7fsn_ti mannonate hydrolyase activity|mannonic hydrolase activity|altronate hydrolase activity|D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)|D-mannonate hydro-lyase activity|D-mannonate hydrolyase activity|altronic hydro-lyase activity RHEA:20097|MetaCyc:MANNONDEHYDRAT-RXN|KEGG_REACTION:R05606|EC:4.2.1.8 molecular_function owl:Class
GO:0061369 biolink:NamedThing negative regulation of testicular blood vessel morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis in the testicle. got7fsn_ti negative regulation of testicular vasculature morphogenesis dph 2010-10-27T02:47:14Z biological_process owl:Class
GO:0039700 biolink:NamedThing fusion of viral membrane with host outer nuclear membrane Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit. got7fsn_ti viral primary envelope fusion with host outer nuclear membrane|fusion of viral membrane with host outer nuclear membrane involved in nuclear egress bf 2013-11-06T15:07:46Z biological_process owl:Class
GO:0099625 biolink:NamedThing ventricular cardiac muscle cell membrane repolarization The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. got7fsn_ti biological_process owl:Class
GO:0047229 biolink:NamedThing 13-hydroxydocosanoate 13-beta-glucosyltransferase activity Catalysis of the reaction: 13-hydroxydocosanoate + UDP-D-glucose = 13-beta-D-glucosyloxydocosanoate + UDP. got7fsn_ti UDPglucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity|UDP-glucose-13-hydroxydocosanoate glucosyltransferase activity|UDP-glucose:13-hydroxydocosanoic acid glucosyltransferase activity|uridine diphosphoglucose-hydroxydocosanoate glucosyltransferase activity|UDP-glucose:13-hydroxydocosanoate 13-beta-D-glucosyltransferase activity|13-glucosyloxydocosanoate 2'-beta-glucosyltransferase activity EC:2.4.1.158|RHEA:22316|MetaCyc:HYDROXYDOCOSANOATE-TRANS-RXN molecular_function owl:Class
GO:0019709 biolink:NamedThing iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase. got7fsn_ti iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide RESID:AA0310 biological_process owl:Class
GO:0048067 biolink:NamedThing cuticle pigmentation Establishment of a pattern of pigment in the cuticle of an organism. got7fsn_ti biological_process owl:Class
GO:0035484 biolink:NamedThing adenine/adenine mispair binding Binding to a double-stranded DNA region containing an A/A mispair. got7fsn_ti A/A mispair binding bf 2010-04-23T10:54:52Z molecular_function owl:Class
GO:0070898 biolink:NamedThing RNA polymerase III preinitiation complex assembly The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter. got7fsn_ti RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly|RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly|RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly|RNA polymerase III transcription PIC formation|RNA polymerase III transcriptional preinitiation complex formation|RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly|RNA polymerase III transcriptional preinitiation complex assembly|RNA polymerase III transcription PIC biosynthesis mah 2010-08-19T04:16:04Z GO:0000999|GO:0001021|GO:0001020|GO:0001043 biological_process owl:Class
GO:0102104 biolink:NamedThing demethoxycurcumin synthase activity Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + feruloyl-CoA + H2O <=> demethoxycurcumin + 2 coenzyme A + carbon dioxide. got7fsn_ti MetaCyc:RXN-11224 molecular_function owl:Class
GO:0080159 biolink:NamedThing zygote elongation The process in which the zygote irreversibly increases in size in one dimension after fertilization. An example of such a process is found in Arabidopsis thaliana. got7fsn_ti dhl 2010-09-01T04:07:51Z biological_process owl:Class
GO:0102331 biolink:NamedThing heptadecanoyl-[acp] elongase/decarboxylase activity Catalysis of the reaction: malonyl-CoA + 3 H+ + a heptodecanoyl-[acp] = octadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-13259 molecular_function owl:Class
GO:0102577 biolink:NamedThing 3-oxo-palmitate decarboxylase activity Catalysis of the reaction: 3-oxopalmitic acid + H+ = 2-pentadecanone + carbon dioxide. got7fsn_ti EC:4.1.1.56|MetaCyc:RXN-15283 molecular_function owl:Class
GO:0018771 biolink:NamedThing 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate. got7fsn_ti (2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity|2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity GO:0008680 MetaCyc:MHPCHYDROL-RXN|RHEA:24789|EC:3.7.1.14|UM-BBD_reactionID:r0438 molecular_function owl:Class
GO:0098827 biolink:NamedThing endoplasmic reticulum subcompartment A distinct region of the endoplasmic reticulum. got7fsn_ti cellular_component owl:Class
GO:0110153 biolink:NamedThing RNA NAD-cap (NMN-forming) hydrolase activity Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+). got7fsn_ti This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. kmv 2019-07-08T17:15:59Z RHEA:60876 molecular_function owl:Class
GO:0038119 biolink:NamedThing CCL19-activated CCR7 signaling pathway A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CCL19-activated CCR7 signalling pathway bf 2012-03-22T11:47:24Z biological_process owl:Class
GO:0038118 biolink:NamedThing C-C chemokine receptor CCR7 signaling pathway A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti C-C chemokine receptor CCR7 signalling pathway|CCR7 signaling pathway This term was created to show the binding of cytokines to multiple receptor types, and vice-versa. Known agonists of chemokine receptor type 7 (CCR7) are C-C chemokines CCL19 and CCL21. Consider instead annotating to one of the child terms 'CCL19-activated CCR7 signaling pathway ; GO:0038119' and/or 'CCL21-activated CCR7 signaling pathway ; GO:0038120'. bf 2012-03-22T11:43:57Z biological_process owl:Class
GO:0030681 biolink:NamedThing multimeric ribonuclease P complex A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species. got7fsn_ti multimeric RNase P complex cellular_component owl:Class
GO:0061805 biolink:NamedThing mitotic spindle elongation (spindle phase three) The cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B. got7fsn_ti mitotic spindle elongation during anaphase|mitotic anaphase spindle elongation|mitotic spindle elongation during mitotic anaphase dph 2016-11-06T23:09:43Z biological_process owl:Class
GO:0097484 biolink:NamedThing dendrite extension Long distance growth of a single dendrite involved in cellular development. got7fsn_ti pr 2013-07-08T09:52:31Z biological_process owl:Class
GO:0003108 biolink:NamedThing negative regulation of the force of heart contraction by chemical signal Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine. got7fsn_ti negative regulation of the force of heart muscle contraction by chemical signal biological_process owl:Class
GO:1900587 biolink:NamedThing arugosin biosynthetic process The chemical reactions and pathways resulting in the formation of arugosin. got7fsn_ti arugosin formation|arugosin biosynthesis|arugosin anabolism|arugosin synthesis di 2012-05-15T06:48:45Z biological_process owl:Class
GO:1990730 biolink:NamedThing VCP-NSFL1C complex A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97. got7fsn_ti p97-p47 complex bf 2015-04-20T12:27:35Z cellular_component owl:Class
GO:0032598 biolink:NamedThing B cell receptor transport into immunological synapse The directed movement of a B cell receptor into an immunological synapse. got7fsn_ti B cell receptor translocation into immunological synapse|BCR translocation into immunological synapse|BCR transport into immunological synapse biological_process owl:Class
GO:0032597 biolink:NamedThing B cell receptor transport into membrane raft The directed movement of a B cell receptor into a membrane raft. got7fsn_ti B cell receptor transport into lipid raft|BCR transport into membrane raft|BCR translocation into membrane raft|B cell receptor translocation into membrane raft biological_process owl:Class
GO:0038172 biolink:NamedThing interleukin-33-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-33 signaling pathway|IL33 signaling pathway|interleukin-33-mediated signalling pathway|IL-33-mediated signaling pathway bf 2012-06-12T10:57:35Z biological_process owl:Class
GO:0030985 biolink:NamedThing high molecular weight kininogen binding Binding to a kininogen of high molecular mass. got7fsn_ti HK binding|HMW kininogen binding molecular_function owl:Class
GO:0047701 biolink:NamedThing beta-L-arabinosidase activity Catalysis of the reaction: H2O + a beta-L-arabinoside = L-arabinose + an alcohol. got7fsn_ti beta-L-arabinoside arabinohydrolase activity|vicianosidase activity|b-L-arabinosidase activity MetaCyc:BETA-L-ARABINOSIDASE-RXN|EC:3.2.1.88 molecular_function owl:Class
GO:0071041 biolink:NamedThing antisense RNA transcript catabolic process The chemical reactions and pathways resulting in the breakdown of antisense transcripts, i.e. transcripts that were produced from the antisense strand of a gene that produces a gene product and which often have a regulatory effect on the transcription of that gene product. got7fsn_ti krc 2009-07-29T01:39:36Z biological_process owl:Class
GO:0044014 biolink:NamedThing histone acetyltransferase activity (H2B-K5 specific) Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5). got7fsn_ti histone lysine N-acetyltransferase activity (H2B-K5 specific) molecular_function owl:Class
GO:1990698 biolink:NamedThing palmitoleoyltransferase activity Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule. got7fsn_ti sp 2015-03-13T08:58:25Z molecular_function owl:Class
GO:0045915 biolink:NamedThing positive regulation of catecholamine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine. got7fsn_ti upregulation of catecholamine metabolic process|activation of catecholamine metabolic process|stimulation of catecholamine metabolic process|up-regulation of catecholamine metabolic process|positive regulation of catecholamine metabolism|up regulation of catecholamine metabolic process biological_process owl:Class
GO:0080116 biolink:NamedThing glucuronoxylan glucuronosyltransferase activity Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule. got7fsn_ti dhl 2009-04-27T03:33:49Z molecular_function owl:Class
GO:0035527 biolink:NamedThing 3-hydroxypropionate dehydrogenase (NADP+) activity Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH. got7fsn_ti 3-hydroxypropanoate dehydrogenase (NADP+) activity|3-hydroxypropionate:NADP+ oxidoreductase|3-hydroxypropanoate:NADP+ oxidoreductase bf 2010-05-05T10:55:07Z MetaCyc:RXN-8974|RHEA:26438|KEGG_REACTION:R09289|EC:1.1.1.298 molecular_function owl:Class
GO:0045947 biolink:NamedThing negative regulation of translational initiation Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation. got7fsn_ti down regulation of translational initiation|downregulation of translational initiation|down-regulation of translational initiation|inhibition of translational initiation biological_process owl:Class
GO:0045460 biolink:NamedThing sterigmatocystin metabolic process The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. got7fsn_ti sterigmatocystin metabolism biological_process owl:Class
GO:0004935 biolink:NamedThing adrenergic receptor activity Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. got7fsn_ti adrenoceptor activity Wikipedia:Adrenergic_receptor molecular_function owl:Class
GO:0023025 biolink:NamedThing MHC class Ib protein complex binding Binding to a class Ib major histocompatibility complex. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0036373 biolink:NamedThing L-fucose mutarotase activity Catalysis of the reaction: alpha-L-fucose = beta-L-fucose. got7fsn_ti fucose 1-epimerase activity|alpha-L-fucose 1-epimerase activity|type-2 mutarotase activity bf 2013-05-07T09:51:06Z EC:5.1.3.29|RHEA:25580|MetaCyc:RXN0-5298 molecular_function owl:Class
GO:0018584 biolink:NamedThing 2,4,5-trichlorophenoxyacetic acid oxygenase activity Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol. got7fsn_ti UM-BBD_reactionID:r0359|EC:1.13.99.- molecular_function owl:Class
GO:1900082 biolink:NamedThing negative regulation of arginine catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of arginine catabolic process. got7fsn_ti down-regulation of arginine catabolism|inhibition of arginine catabolism|inhibition of arginine catabolic process|downregulation of arginine catabolic process|inhibition of arginine degradation|negative regulation of arginine degradation|down regulation of arginine catabolism|down regulation of arginine catabolic process|down regulation of arginine breakdown|downregulation of arginine breakdown|inhibition of arginine breakdown|down-regulation of arginine breakdown|down-regulation of arginine degradation|downregulation of arginine degradation|negative regulation of arginine breakdown|down regulation of arginine degradation|down-regulation of arginine catabolic process|negative regulation of arginine catabolism|downregulation of arginine catabolism pr 2012-02-01T04:04:45Z biological_process owl:Class
GO:0098869 biolink:NamedThing cellular oxidant detoxification Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide. got7fsn_ti biological_process owl:Class
GO:0097522 biolink:NamedThing protein-DNA ISRE complex A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA. got7fsn_ti pr 2013-10-17T14:35:07Z cellular_component owl:Class
GO:2000816 biolink:NamedThing negative regulation of mitotic sister chromatid separation Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation. got7fsn_ti negative regulation of mitotic chromosome separation|negative regulation of sister chromatid separation during mitosis|negative regulation of mitotic sister chromatid resolution|negative regulation of chromosome separation during mitosis mah 2011-07-11T04:45:06Z biological_process owl:Class
GO:0021793 biolink:NamedThing chemorepulsion of branchiomotor axon The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti negative chemotaxis of branchiomotor axon biological_process owl:Class
GO:0061643 biolink:NamedThing chemorepulsion of axon The process in which a neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. got7fsn_ti dph 2014-08-29T08:35:40Z biological_process owl:Class
GO:0071069 biolink:NamedThing alpha4-beta1 integrin-thrombospondin-1 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-1. got7fsn_ti ITGA4-ITGB1-THBS1 complex mah 2009-11-03T04:05:35Z cellular_component owl:Class
GO:0035248 biolink:NamedThing alpha-1,4-N-acetylgalactosaminyltransferase activity Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage. got7fsn_ti alpha-1,4-GalNAc transferase activity molecular_function owl:Class
GO:0045482 biolink:NamedThing trichodiene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene. got7fsn_ti trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase activity|trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming)|sesquiterpene cyclase activity|trichodiene synthetase activity RHEA:12052|EC:4.2.3.6|KEGG_REACTION:R02306|MetaCyc:TRICHODIENE-SYNTHASE-RXN molecular_function owl:Class
GO:0035201 biolink:NamedThing leg disc anterior/posterior lineage restriction Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment. got7fsn_ti biological_process owl:Class
GO:0048099 biolink:NamedThing anterior/posterior lineage restriction, imaginal disc Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment. got7fsn_ti biological_process owl:Class
GO:0140596 biolink:NamedThing TOM complex A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane. got7fsn_ti translocase of the outer mitochondrial membrane https://github.com/geneontology/go-ontology/issues/20669 pg 2021-02-09T19:43:51Z cellular_component owl:Class
GO:0030185 biolink:NamedThing nitric oxide transport The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1990069 biolink:NamedThing stomatal opening The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. got7fsn_ti tb 2013-03-27T21:18:48Z biological_process owl:Class
GO:0004430 biolink:NamedThing 1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+). got7fsn_ti phosphatidylinositol kinase activity|PI4K-alpha activity|ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity|PI4-kinase activity|PI4K|PtdIns-4-kinase activity|phosphatidylinositol kinase (phosphorylating) activity|PI 4-kinase activity|PI kinase activity|type II phosphatidylinositol kinase activity|phosphatidylinositol 4-kinase activity Reactome:R-HSA-1675813|Reactome:R-HSA-1676185|MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN|RHEA:19877|Reactome:R-HSA-1675974|Reactome:R-HSA-1675780|Reactome:R-HSA-1675883|KEGG_REACTION:R03361|EC:2.7.1.67 molecular_function owl:Class
GO:0097389 biolink:NamedThing chemokine (C-C motif) ligand 21 production The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CCL21 production pr 2012-10-23T07:56:26Z biological_process owl:Class
GO:0015145 biolink:NamedThing monosaccharide transmembrane transporter activity Enables the transfer of a monosaccharide from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0051119 biolink:NamedThing sugar transmembrane transporter activity Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. got7fsn_ti sugar/polyol channel activity Reactome:R-HSA-8876319|Reactome:R-HSA-8875902|Reactome:R-HSA-428779 molecular_function owl:Class
GO:0001639 biolink:NamedThing PLC activating G protein-coupled glutamate receptor activity A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system. got7fsn_ti PLC activating metabotropic glutamate receptor activity|group I metabotropic glutamate receptor activity|PLC activating G-protein coupled glutamate receptor activity|Group I metabotropic glutamate receptor|phospholipase C activating metabotropic glutamate receptor activity molecular_function owl:Class
GO:0140613 biolink:NamedThing P-type manganese transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20918 pg 2021-03-03T22:11:36Z RHEA:66820 molecular_function owl:Class
GO:1990666 biolink:NamedThing PCSK9-LDLR complex A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway. got7fsn_ti PCSK9/LDL-R complex|PCSK9:EGF-A complex|PCSK9:low-density lipoprotein receptor complex|PCSK9.LDLR complex bf 2015-03-02T10:19:15Z cellular_component owl:Class
GO:0015491 biolink:NamedThing cation:cation antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). got7fsn_ti molecular_function owl:Class
GO:0075247 biolink:NamedThing aeciospore formation The process in which a dikaryotic spore of typically a rust fungus is produced in an aecium; in heteroecious rusts, the aeciospore is a spore stage that infects the alternate host. got7fsn_ti biological_process owl:Class
GO:0038200 biolink:NamedThing ethylene receptor histidine kinase activity Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. got7fsn_ti bf 2013-12-05T16:25:15Z molecular_function owl:Class
GO:0038199 biolink:NamedThing ethylene receptor activity Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity. got7fsn_ti C2H4 receptor activity|ethylene response sensor bf 2013-12-05T16:06:13Z molecular_function owl:Class
GO:1902405 biolink:NamedThing mitotic actomyosin contractile ring localization Any actomyosin contractile ring localization that is involved in mitotic cell cycle. got7fsn_ti contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle|contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle jl 2013-09-12T12:28:05Z biological_process owl:Class
GO:0050337 biolink:NamedThing thiosulfate-thiol sulfurtransferase activity Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide. got7fsn_ti sulfane sulfurtransferase activity|sulfane reductase activity|thiosulphate-thiol sulphurtransferase activity|glutathione-dependent thiosulfate reductase activity|thiosulfate:thiol sulfurtransferase activity RHEA:14505|EC:2.8.1.3|MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN|Reactome:R-HSA-1655879 molecular_function owl:Class
GO:0090696 biolink:NamedThing post-embryonic plant organ development Development, taking place during the post-embryonic phase of a plant tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. got7fsn_ti tb 2016-08-25T16:35:55Z biological_process owl:Class
GO:0035347 biolink:NamedThing negative regulation of hypoxanthine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti negative regulation of 6-hydroxypurine transport bf 2010-03-04T10:43:53Z biological_process owl:Class
GO:0033071 biolink:NamedThing vancomycin metabolic process The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria. got7fsn_ti vancomycin metabolism biological_process owl:Class
GO:0035796 biolink:NamedThing ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP. got7fsn_ti energy coupling factor (ECF)-type ABC transporter|ATP-binding cassette (ABC) transporter complex, ECF-type|energy-coupling factor transporter The ECF-type transporters differs from other types of ABC transporters because the substrate-binding subunit lies integral to the membrane. bf 2011-04-11T02:02:41Z cellular_component owl:Class
GO:0110104 biolink:NamedThing mRNA alternative polyadenylation The process of generating multiple mRNA molecules with variable 3'-end length formation from a given pre-mRNA by differential use of cleavage and polyadenylation signals (pA signals). got7fsn_ti kmv 2018-03-27T19:26:56Z biological_process owl:Class
GO:1900363 biolink:NamedThing regulation of mRNA polyadenylation Any process that modulates the frequency, rate or extent of mRNA polyadenylation. got7fsn_ti regulation of mRNA polyadenylylation|regulation of cleavage and polyadenylylation specificity factor activity pr 2012-04-12T04:36:21Z biological_process owl:Class
GO:0052785 biolink:NamedThing cellulose catabolism by endo-processive cellulases The breakdown into simpler components of cellulose. Catabolism is initiated by endohydrolytic attacks on the cellulose chain, and the resulting pieces are further degraded by cellulase enzymes to produce smaller and smaller fragments. got7fsn_ti endo-processive cellulase activity ai 2011-10-04T09:31:16Z biological_process owl:Class
GO:0044743 biolink:NamedThing protein transmembrane import into intracellular organelle The directed movement of proteins into an intracellular organelle, across a membrane. got7fsn_ti jl 2012-11-07T15:37:36Z biological_process owl:Class
GO:0090643 biolink:NamedThing inflorescence phyllotactic patterning The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem. got7fsn_ti tb 2015-05-05T14:25:09Z biological_process owl:Class
GO:0060771 biolink:NamedThing phyllotactic patterning The radial pattern formation process that results in the formation of plant organs (leaves or leaf-like structures) or flower primordia around a central axis. got7fsn_ti dph 2009-07-25T06:20:33Z biological_process owl:Class
GO:0018351 biolink:NamedThing peptidyl-cysteine esterification The addition of an ester group to a cysteine residue in a protein. got7fsn_ti biological_process owl:Class
GO:0044458 biolink:NamedThing motile cilium assembly The aggregation, arrangement and bonding together of a set of components to form a motile cilium. got7fsn_ti nodal cilium assembly|motile primary cilium formation|motile primary cilium assembly|motile primary cilia assembly|motile primary cilia formation|nodal cilium formation krc 2015-02-06T17:23:23Z GO:1903887 biological_process owl:Class
GO:0051745 biolink:NamedThing 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+ = isopentenyl diphosphate + NAD(P)+ + H2O. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative name for 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. got7fsn_ti 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity|isopentenyl-diphosphate:NAD(P)+ oxidoreductase activity EC:1.17.7.4|MetaCyc:ISPH2-RXN molecular_function owl:Class
GO:0050342 biolink:NamedThing tocopherol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol. got7fsn_ti S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase activity|gamma-tocopherol methyltransferase activity MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN|RHEA:24012|EC:2.1.1.95 molecular_function owl:Class
GO:0051269 biolink:NamedThing alpha-keto ester reductase activity Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic. got7fsn_ti EC:1.2.-.- molecular_function owl:Class
GO:0006163 biolink:NamedThing purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti purine nucleotide metabolism|purine metabolism|purine metabolic process biological_process owl:Class
GO:0006178 biolink:NamedThing guanine salvage Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis. got7fsn_ti guanine, xanthine and their nucleoside salvage biological_process owl:Class
GO:0010350 biolink:NamedThing cellular response to magnesium starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium. got7fsn_ti biological_process owl:Class
GO:0019102 biolink:NamedThing male somatic sex determination The determination of sex and sexual phenotypes in a male organism's soma. got7fsn_ti biological_process owl:Class
GO:0009401 biolink:NamedThing phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. got7fsn_ti PTS system biological_process owl:Class
GO:0031778 biolink:NamedThing type 2 melanin-concentrating hormone receptor binding Binding to a type 2 melanin-concentrating hormone receptor. got7fsn_ti type 2 melanin-concentrating hormone receptor ligand molecular_function owl:Class
GO:1902727 biolink:NamedThing negative regulation of growth factor dependent skeletal muscle satellite cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. got7fsn_ti mr 2014-02-24T16:10:24Z biological_process owl:Class
GO:1902723 biolink:NamedThing negative regulation of skeletal muscle satellite cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation. got7fsn_ti down-regulation of satellite cell proliferation|down regulation of satellite cell proliferation|downregulation of satellite cell proliferation|inhibition of satellite cell proliferation mr 2014-02-24T16:09:46Z biological_process owl:Class
GO:0140293 biolink:NamedThing ADP-ribosylglutamate hydrolase activity Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + ADP-ribose. got7fsn_ti pg 2018-11-22T14:36:37Z molecular_function owl:Class
GO:0031084 biolink:NamedThing BLOC-2 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru. got7fsn_ti cellular_component owl:Class
GO:0044269 biolink:NamedThing glycerol ether catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. got7fsn_ti glycerol ether catabolism|glycerol ether breakdown|glycerol ether degradation biological_process owl:Class
GO:0034250 biolink:NamedThing positive regulation of cellular amide metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides. got7fsn_ti positive regulation of amide metabolism biological_process owl:Class
GO:0046897 biolink:NamedThing N-terminal peptidyl-tyrosine methylation The methylation of the N-terminal tyrosine of proteins to form the derivative N-methyl-L-tyrosine. got7fsn_ti RESID:AA0338 biological_process owl:Class
GO:0090536 biolink:NamedThing NoRC complex An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters. got7fsn_ti tb 2013-02-11T14:07:14Z cellular_component owl:Class
GO:0045725 biolink:NamedThing positive regulation of glycogen biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen. got7fsn_ti positive regulation of glycogen biosynthesis|positive regulation of glycogen formation|up regulation of glycogen biosynthetic process|positive regulation of glycogen synthesis|stimulation of glycogen biosynthetic process|positive regulation of glycogen anabolism|up-regulation of glycogen biosynthetic process|activation of glycogen biosynthetic process|upregulation of glycogen biosynthetic process biological_process owl:Class
GO:0002254 biolink:NamedThing kinin cascade A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. got7fsn_ti biological_process owl:Class
GO:0043741 biolink:NamedThing alpha-aminoadipate acetyltransferase activity Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A. got7fsn_ti L-2-aminoadipate N-acetyltransferase activity https://github.com/geneontology/go-ontology/issues/18958 GO:0043869 MetaCyc:RXN-5181 molecular_function owl:Class
GO:0090593 biolink:NamedThing peptidyl-histidine autophosphorylation The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein. got7fsn_ti tb 2014-06-06T14:19:46Z biological_process owl:Class
GO:0098780 biolink:NamedThing response to mitochondrial depolarisation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) in response to the depolarization of one or more mitochondria. got7fsn_ti biological_process owl:Class
GO:0044224 biolink:NamedThing juxtaparanode region of axon A region of an axon near a node of Ranvier that is between the paranode and internode regions. got7fsn_ti juxta paranode axon|juxtaparanodal region|juxtaparanode jl 2009-11-13T12:57:36Z NIF_Subcellular:sao758620702 cellular_component owl:Class
GO:0034828 biolink:NamedThing 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+. got7fsn_ti UM-BBD_reactionID:r1172 molecular_function owl:Class
GO:1990381 biolink:NamedThing ubiquitin-specific protease binding Binding to a ubiquitin-specific protease. got7fsn_ti deubiquitinating enzyme binding|deubiquitinase binding bf 2014-05-19T10:01:53Z molecular_function owl:Class
GO:0033437 biolink:NamedThing ACU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACU codon. got7fsn_ti threonine tRNA|ACT codon-amino acid adaptor activity Note that in the standard genetic code, ACT codes for threonine. molecular_function owl:Class
GO:0046887 biolink:NamedThing positive regulation of hormone secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell. got7fsn_ti up regulation of hormone secretion|stimulation of hormone secretion|activation of hormone secretion|upregulation of hormone secretion|up-regulation of hormone secretion biological_process owl:Class
GO:0061496 biolink:NamedThing half bridge of mitotic spindle pole body Structure adjacent to the plaques of the mitotic spindle pole body. got7fsn_ti dph 2012-12-11T09:13:52Z cellular_component owl:Class
GO:0010148 biolink:NamedThing transpiration Release of water by the plant into the air as water vapor mainly through leaves. got7fsn_ti Wikipedia:Transpiration biological_process owl:Class
GO:0070780 biolink:NamedThing dihydrosphingosine-1-phosphate phosphatase activity Catalysis of the reaction: dihydrosphingosine 1-phosphate + H2O = dihydrosphingosine + phosphate. got7fsn_ti sphinganine-1-phosphate phosphatase activity|dihydrosphingosine-1-phosphate phosphohydrolase activity mah 2009-07-02T02:13:49Z RHEA:27514|MetaCyc:RXN3DJ-25|Reactome:R-HSA-428664 molecular_function owl:Class
GO:0048259 biolink:NamedThing regulation of receptor-mediated endocytosis Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport. got7fsn_ti regulation of receptor mediated endocytosis biological_process owl:Class
GO:0008800 biolink:NamedThing beta-lactamase activity Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. got7fsn_ti beta-lactamase AME I|cephalosporin-beta-lactamase activity|penicillinase I, II|neutrapen|penicillin beta-lactamase activity|exopenicillinase activity|beta-lactam hydrolase activity|penicillin amido-beta-lactamhydrolase activity|beta-lactamase A, B, C|beta-lactamase I-III|ampicillinase activity RHEA:20401|MetaCyc:BETA-LACTAMASE-RXN|EC:3.5.2.6 molecular_function owl:Class
GO:0045127 biolink:NamedThing N-acetylglucosamine kinase activity Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+). got7fsn_ti acetylaminodeoxyglucokinase activity|GlcNAc kinase activity|ATP:2-acetylamino-2-deoxy-D-glucose 6-phosphotransferase activity|acetylglucosamine kinase (phosphorylating)|2-acetylamino-2-deoxy-D-glucose kinase activity|ATP:N-acetyl-D-glucosamine 6-phosphotransferase activity RHEA:17417|EC:2.7.1.59|MetaCyc:N-ACETYLGLUCOSAMINE-KINASE-RXN|KEGG_REACTION:R01201|Reactome:R-HSA-6803771 molecular_function owl:Class
GO:0043724 biolink:NamedThing 2-keto-3-deoxygalactonate aldolase activity Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate. got7fsn_ti KDGal aldolase activity molecular_function owl:Class
GO:0047276 biolink:NamedThing N-acetyllactosaminide 3-alpha-galactosyltransferase activity Catalysis of the reaction: beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP-galactose = alpha-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-N-acetyl-D-glucosaminyl-R + UDP. got7fsn_ti UDP-Gal:N-acetyllactosaminide alpha-(1,3)-galactosyltransferase activity|UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha-(1,3)-galactosyltransferase activity|alpha-galactosyltransferase activity|UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase activity|uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase activity|N-acetyllactosaminide alpha-1,3-galactosyltransferase activity|beta-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity|uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase activity|uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl-glucosylceramide galactosyltransferase activity|uridine diphosphogalactose-acetyllactosamine galactosyltransferase activity|UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase activity|UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase activity|beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase activity|UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase activity|uridine diphosphogalactose-acetyllactosamine alpha-1->3-galactosyltransferase activity|UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase activity|glucosaminylglycopeptide alpha-1,3-galactosyltransferase activity|UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase activity|UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase activity|UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase activity GO:0003946 MetaCyc:2.4.1.151-RXN|EC:2.4.1.87|RHEA:13013 molecular_function owl:Class
GO:0010315 biolink:NamedThing auxin efflux The process involved in the transport of auxin out of the cell. got7fsn_ti auxin export biological_process owl:Class
GO:0021514 biolink:NamedThing ventral spinal cord interneuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0021570 biolink:NamedThing rhombomere 4 development The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0102477 biolink:NamedThing 2,5,7-trihydroxyflavanone 6C-glucoside dehydratase activity Catalysis of the reaction: 6C-glucosyl-2,5,7-trihydroxyflavanone <=> H+ + 6C-hexosyl chrysin + H2O. got7fsn_ti MetaCyc:RXN-14088 molecular_function owl:Class
GO:0034538 biolink:NamedThing 3-methylsalicylaldehyde dehydrogenase activity Catalysis of the reaction: 3-methylsalicylaldehyde + NAD+ = 3-methylsalicylate + NADH + H+. got7fsn_ti UM-BBD_reactionID:r0784 molecular_function owl:Class
GO:0051664 biolink:NamedThing nuclear pore localization Any process in which nuclear pores are transported to, or maintained in, a specific location. got7fsn_ti establishment and maintenance of nuclear pore localization|nuclear pore localisation|nuclear pore distribution|positioning of nuclear pores GO:0031081 biological_process owl:Class
GO:0030644 biolink:NamedThing cellular chloride ion homeostasis Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell. got7fsn_ti biological_process owl:Class
GO:0019029 biolink:NamedThing helical viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure. got7fsn_ti cellular_component owl:Class
GO:0008926 biolink:NamedThing mannitol-1-phosphate 5-dehydrogenase activity Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. got7fsn_ti EC:1.1.1.17|MetaCyc:MANNPDEHYDROG-RXN|RHEA:19661 molecular_function owl:Class
GO:0062241 biolink:NamedThing double strand break-nuclear membrane anchor activity Binding to DNA double strand breaks and the nuclear inner membrane, in order to facilitate DNA repair. got7fsn_ti DNA repair factory dph 2020-04-20T18:23:59Z molecular_function owl:Class
GO:0035723 biolink:NamedThing interleukin-15-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-15-mediated signalling pathway|IL-15-mediated signaling pathway bf 2011-03-07T11:28:29Z biological_process owl:Class
GO:0044834 biolink:NamedThing retroviral intasome A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome. got7fsn_ti jl 2014-02-06T14:33:39Z cellular_component owl:Class
GO:0035129 biolink:NamedThing post-embryonic hindlimb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized. got7fsn_ti biological_process owl:Class
GO:0050039 biolink:NamedThing lactaldehyde reductase (NADPH) activity Catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH. got7fsn_ti 1,2-propanediol:NADP+ oxidoreductase activity|propane-1,2-diol:NADP+ oxidoreductase activity|lactaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|NADP-1,2-propanediol dehydrogenase activity|propanediol dehydrogenase activity MetaCyc:LACTALDEHYDE-REDUCTASE-NADPH-RXN|EC:1.1.1.55|KEGG_REACTION:R02259|RHEA:15885 molecular_function owl:Class
GO:0042371 biolink:NamedThing vitamin K biosynthetic process The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. got7fsn_ti vitamin K biosynthesis|vitamin K synthesis|naphthoquinone metabolic process|naphthoquinone metabolism|vitamin K anabolism|vitamin K formation biological_process owl:Class
GO:0046275 biolink:NamedThing flavonoid catabolic process The chemical reactions and pathways resulting in the breakdown of flavonoids, a group of phenolic derivatives containing a flavan skeleton. got7fsn_ti flavonoid degradation|flavonoid catabolism|flavonoid breakdown biological_process owl:Class
GO:1901575 biolink:NamedThing organic substance catabolic process The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon. got7fsn_ti organic substance breakdown|organic molecular entity breakdown|organic molecular entity catabolic process|organic substance degradation|organic molecular entity degradation|organic molecular entity catabolism|organic substance catabolism pr 2012-11-05T11:04:36Z biological_process owl:Class
GO:0018174 biolink:NamedThing protein-heme P460 linkage The linkage of protein to heme P460. got7fsn_ti protein-haem P460 linkage RESID:AA0266|RESID:AA0271 biological_process owl:Class
GO:0035264 biolink:NamedThing multicellular organism growth The increase in size or mass of an entire multicellular organism, as opposed to cell growth. got7fsn_ti body growth biological_process owl:Class
GO:0000405 biolink:NamedThing bubble DNA binding Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. got7fsn_ti molecular_function owl:Class
GO:0016692 biolink:NamedThing NADH peroxidase activity Catalysis of the reaction: H(2)O(2) + H(+) + NADH = 2 H(2)O + NAD(+). got7fsn_ti diphosphopyridine nucleotide peroxidase activity|NADH:hydrogen-peroxide oxidoreductase activity|NADH-peroxidase activity|DPNH peroxidase activity|nicotinamide adenine dinucleotide peroxidase activity|NAD peroxidase activity RHEA:18509|MetaCyc:NADH-PEROXIDASE-RXN|KEGG_REACTION:R00090|EC:1.11.1.1 molecular_function owl:Class
GO:0034583 biolink:NamedThing 21U-RNA binding Binding to a 21U-RNA, a 21-nucleotide RNA characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. got7fsn_ti molecular_function owl:Class
GO:0062213 biolink:NamedThing peroxynitrite isomerase activity Catalysis of the reaction: peroxynitrite = nitrate. got7fsn_ti dph 2020-02-22T13:57:50Z RHEA:63116 molecular_function owl:Class
GO:0008180 biolink:NamedThing COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. got7fsn_ti signalosome|CSN|COP9 complex cellular_component owl:Class
GO:0033705 biolink:NamedThing GDP-4-dehydro-6-deoxy-D-mannose reductase activity Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. got7fsn_ti GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity|GDP-6-deoxy-D-lyxo-4-hexulose reductase activity|GDP-4-keto-6-deoxy-D-mannose reductase activity|Rmd Note that this enzyme differs from EC:1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-D-rhamnose (GDP-6-deoxy-D-mannose). MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN|EC:1.1.1.281 molecular_function owl:Class
GO:0000737 biolink:NamedThing DNA catabolic process, endonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. got7fsn_ti endonucleolytic DNA catabolism|DNA degradation, endonucleolytic|endonucleolytic degradation of DNA|DNA breakdown, endonucleolytic biological_process owl:Class
GO:0006308 biolink:NamedThing DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. got7fsn_ti DNA breakdown|DNA degradation|DNA catabolism biological_process owl:Class
GO:0102211 biolink:NamedThing unsaturated rhamnogalacturonyl hydrolase activity Catalysis of the reaction: 2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnopyranose(1-) + H2O <=> (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + alpha-L-rhamnopyranose. got7fsn_ti EC:3.2.1.172|RHEA:30927|MetaCyc:RXN-12174 molecular_function owl:Class
GO:0021925 biolink:NamedThing cerebellar Purkinje cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem. got7fsn_ti biological_process owl:Class
GO:0043560 biolink:NamedThing insulin receptor substrate binding Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. got7fsn_ti insulin receptor substrate [protein] binding|IRS binding|IRS [protein] binding molecular_function owl:Class
GO:0033153 biolink:NamedThing T cell receptor V(D)J recombination The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). got7fsn_ti T cell receptor V-D-J recombination|T cell receptor V-D-J joining|T cell receptor V-J joining|T cell receptor V-J recombination|T cell receptor V(D)J joining|T-cell receptor V(D)J recombination|TCR V(D)J recombination biological_process owl:Class
GO:0033151 biolink:NamedThing V(D)J recombination The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). got7fsn_ti V(D)J joining|V-J recombination|V-J joining|V-D-J joining|V-D-J recombination Wikipedia:V(D)J_recombination biological_process owl:Class
GO:0047008 biolink:NamedThing pregnan-21-ol dehydrogenase (NADP+) activity Catalysis of the reaction: NADP(+) + pregnan-21-ol = H(+) + NADPH + pregnan-21-al. got7fsn_ti 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|21-hydroxy steroid dehydrogenase activity|NADP-21-hydroxysteroid dehydrogenase activity|21-hydroxysteroid dehydrogenase (NADP+) activity|21-hydroxysteroid:NADP+ 21-oxidoreductase activity|21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide phosphate) activity EC:1.1.1.151|MetaCyc:1.1.1.151-RXN|RHEA:23712|KEGG_REACTION:R03044 molecular_function owl:Class
GO:1990361 biolink:NamedThing PKM2 pyruvate kinase complex A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013). got7fsn_ti PKM2 homotetramer An example of this is PKM2 in human (P14618) in PMID:24606918 (inferred from direct assay). bhm 2014-04-17T14:16:24Z cellular_component owl:Class
GO:0070556 biolink:NamedThing TAF4B-containing transcription factor TFIID complex A transcription factor TFIID complex that contains the TBP-associated factor TAF4B (also known as TAFII105 in human), a cell-type-specific variant of TAF4. got7fsn_ti TFIID complex, B-cell specific cellular_component owl:Class
GO:0061788 biolink:NamedThing EGF repeat binding Binding to Epidermal Growth Factor (EGF) repeats. got7fsn_ti Epidermal Growth Factor repeat binding|Epidermal growth factor domain binding dph 2016-09-08T15:22:28Z molecular_function owl:Class
GO:1990791 biolink:NamedThing dorsal root ganglion development The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure. got7fsn_ti DRG development sl 2015-07-02T22:09:54Z biological_process owl:Class
GO:0098562 biolink:NamedThing cytoplasmic side of membrane The side of a membrane that faces the cytoplasm. got7fsn_ti dos 2013-12-12T11:21:30Z cellular_component owl:Class
GO:0047788 biolink:NamedThing 2-coumarate reductase activity Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + NAD(+) = trans-2-coumarate + H(+) + NADH. got7fsn_ti coumarate reductase activity|3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase activity|melilotate dehydrogenase activity MetaCyc:COUMARATE-REDUCTASE-RXN|RHEA:21444|EC:1.3.1.11|KEGG_REACTION:R03709 molecular_function owl:Class
GO:0000704 biolink:NamedThing pyrimidine dimer DNA N-glycosylase activity Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. got7fsn_ti molecular_function owl:Class
GO:0021956 biolink:NamedThing central nervous system interneuron axonogenesis Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region. got7fsn_ti biological_process owl:Class
GO:0052589 biolink:NamedThing malate dehydrogenase (menaquinone) activity Catalysis of the reaction: (S)-malate + a menaquinone = oxaloacetate + a menaquinol. got7fsn_ti (S)-malate:menaquinone oxidoreductase activity|(S)-malate:(menaquinone) oxidoreductase activity EC:1.1.5.4|MetaCyc:RXNI-3 molecular_function owl:Class
GO:0098987 biolink:NamedThing regulation of modification of synapse structure, modulating synaptic transmission Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:1905244 biolink:NamedThing regulation of modification of synaptic structure Any process that modulates the frequency, rate or extent of modification of synaptic structure. got7fsn_ti regulation of synapse remodelling dos 2016-06-09T09:43:40Z biological_process owl:Class
GO:0098824 biolink:NamedThing peptidyl-cysteine sulfation The sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine. got7fsn_ti RESID:AA0171 biological_process owl:Class
GO:0048755 biolink:NamedThing branching morphogenesis of a nerve The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). got7fsn_ti biological_process owl:Class
GO:0080079 biolink:NamedThing cellobiose glucosidase activity Catalysis of the reaction: cellobiose + H2O = 2 D-glucose. got7fsn_ti cellobiose glucohydrolase activity dhl 2009-04-14T04:07:16Z MetaCyc:RXN-10773 molecular_function owl:Class
GO:0010907 biolink:NamedThing positive regulation of glucose metabolic process Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. got7fsn_ti positive regulation of glucose metabolism biological_process owl:Class
GO:0106080 biolink:NamedThing GATOR1 complex binding Binding to a GATOR1 complex. got7fsn_ti hjd 2017-12-22T14:49:54Z molecular_function owl:Class
GO:0043797 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin. got7fsn_ti D-glyceraldehyde-3-phosphate:ferredoxin oxidoreductase activity|glyceraldehyde-3-phosphate Fd oxidoreductase activity|GAPOR|glyceraldehyde-3-phosphate ferredoxin reductase activity EC:1.2.7.6|RHEA:24148|MetaCyc:1.2.7.6-RXN molecular_function owl:Class
GO:0009385 biolink:NamedThing N-acylmannosamine-6-phosphate 2-epimerase activity Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate. got7fsn_ti N-acylmannosamine-6-P epimerase activity EC:5.1.3.9|RHEA:25257|MetaCyc:NANE-RXN molecular_function owl:Class
GO:0042814 biolink:NamedThing monopolar cell growth Polarized growth from one end of a cell. got7fsn_ti monopolar growth|polar cell elongation|monopolar cell elongation biological_process owl:Class
GO:0035809 biolink:NamedThing regulation of urine volume Any process that modulates the amount of urine excreted from the body over a unit of time. got7fsn_ti regulation of urinary volume|regulation of urine flow bf 2011-04-20T01:17:38Z biological_process owl:Class
GO:1900589 biolink:NamedThing violaceol I catabolic process The chemical reactions and pathways resulting in the breakdown of violaceol I. got7fsn_ti violaceol I degradation|violaceol I catabolism|violaceol I breakdown di 2012-05-15T06:51:09Z biological_process owl:Class
GO:0102223 biolink:NamedThing 4,4'-diapophytoene desaturase activity Catalysis of the reaction: 4 H+ + 15-cis-4,4'-diapophytoene + 4 FAD <=> 4,4'-diapolycopene + 4 FADH2. got7fsn_ti RHEA:31391|EC:1.3.8.2|MetaCyc:RXN-12224 molecular_function owl:Class
GO:0034429 biolink:NamedThing tectobulbar tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the optic tectum towards target cells in the premotor reticulospinal system in the hindbrain. got7fsn_ti biological_process owl:Class
GO:0061156 biolink:NamedThing pulmonary artery morphogenesis The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs. got7fsn_ti dph 2010-06-15T09:13:47Z biological_process owl:Class
GO:0002779 biolink:NamedThing antibacterial peptide secretion The regulated release of an antibacterial peptide from a cell or a tissue. got7fsn_ti biological_process owl:Class
GO:0090001 biolink:NamedThing replication fork arrest at tRNA locus A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit. got7fsn_ti tb 2009-06-24T11:36:15Z biological_process owl:Class
GO:0047010 biolink:NamedThing hydroxycyclohexanecarboxylate dehydrogenase activity Catalysis of the reaction: (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD(+) = (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + H(+) + NADH. got7fsn_ti (-)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD oxidoreductase activity|dihydroxycyclohexanecarboxylate dehydrogenase activity|(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD+ 3-oxidoreductase activity RHEA:10516|EC:1.1.1.166|KEGG_REACTION:R05315|MetaCyc:1.1.1.166-RXN molecular_function owl:Class
GO:0007278 biolink:NamedThing pole cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0008608 biolink:NamedThing attachment of spindle microtubules to kinetochore The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. got7fsn_ti microtubule and chromosome interaction|microtubule and kinetochore interaction|spindle chromosome attachment|bipolar attachment|attachment of spindle microtubules to chromosome|spindle kinetochore attachment|amphotelic attachment|microtubule capture|microtubule anchoring at kinetochore|kinetochore-microtubule attachment|kinetochore microtubule interaction|spindle-chromosome interaction|kinetochore-microtubule interaction This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation). GO:0051313 biological_process owl:Class
GO:0043552 biolink:NamedThing positive regulation of phosphatidylinositol 3-kinase activity Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity. got7fsn_ti stimulation of phosphatidylinositol 3-kinase activity|upregulation of phosphatidylinositol 3-kinase activity|up regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphoinositide 3-kinase activity|activation of phosphatidylinositol 3-kinase activity|up-regulation of phosphatidylinositol 3-kinase activity biological_process owl:Class
GO:0052789 biolink:NamedThing mannan 1,3-beta-mannosidase activity Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose. got7fsn_ti exo-1,3-mannanase activity|1,3-beta-D-mannan mannanohydrolase activity|exo-beta-1,3-mannase activity|beta-1,3-mannan 3-mannanohydrolase activity|exo-1,3-beta-mannanase activity ai 2011-10-04T01:11:41Z molecular_function owl:Class
GO:0030269 biolink:NamedThing tetrahydromethanopterin S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM. got7fsn_ti tetrahydromethanopterin methyltransferase activity|N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity|N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity|5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity GO:0018709 UM-BBD_reactionID:r0355|RHEA:53492|KEGG_REACTION:R04347|MetaCyc:2.1.1.86-RXN|EC:2.1.1.86 molecular_function owl:Class
GO:0042086 biolink:NamedThing 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin. got7fsn_ti molecular_function owl:Class
GO:0018926 biolink:NamedThing methanesulfonic acid metabolic process The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide. got7fsn_ti methanesulphonic acid metabolic process|methanesulphonic acid metabolism|methanesulfonic acid metabolism UM-BBD_pathwayID:msa biological_process owl:Class
GO:0047018 biolink:NamedThing indole-3-acetaldehyde reductase (NADH) activity Catalysis of the reaction: indole-3-ethanol + NAD(+) = (indol-3-yl)acetaldehyde + H(+) + NADH. got7fsn_ti indoleacetaldehyde reductase activity|(indol-3-yl)ethanol:NAD+ oxidoreductase activity|indole-3-ethanol:NAD+ oxidoreductase activity EC:1.1.1.190|KEGG_REACTION:R02679|RHEA:14873|MetaCyc:1.1.1.190-RXN molecular_function owl:Class
GO:0051886 biolink:NamedThing negative regulation of timing of anagen Any process that stops, prevents, or reduces the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. got7fsn_ti downregulation of anagen|down-regulation of anagen|inhibition of anagen|negative regulation of anagen|down regulation of anagen biological_process owl:Class
GO:0048817 biolink:NamedThing negative regulation of hair follicle maturation Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation. got7fsn_ti downregulation of hair follicle maturation|down-regulation of hair follicle maturation|inhibition of hair follicle maturation|down regulation of hair follicle maturation biological_process owl:Class
GO:0045773 biolink:NamedThing positive regulation of axon extension Any process that activates or increases the frequency, rate or extent of axon extension. got7fsn_ti up regulation of axon extension|upregulation of axon extension|stimulation of axon extension|activation of axon extension|up-regulation of axon extension biological_process owl:Class
GO:0090677 biolink:NamedThing reversible differentiation A phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another. got7fsn_ti tb 2016-04-28T17:32:40Z biological_process owl:Class
GO:0051969 biolink:NamedThing regulation of transmission of nerve impulse Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. got7fsn_ti regulation of conduction of nerve impulse biological_process owl:Class
GO:0035737 biolink:NamedThing injection of substance in to other organism The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes. got7fsn_ti bf 2011-03-17T10:58:57Z biological_process owl:Class
GO:1990298 biolink:NamedThing bub1-bub3 complex Protein complex that associates with the kinetochores. got7fsn_ti al 2014-02-26T09:23:04Z cellular_component owl:Class
GO:0036167 biolink:NamedThing phenotypic switching in response to host A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. got7fsn_ti bf 2012-03-27T01:44:24Z biological_process owl:Class
GO:0032475 biolink:NamedThing otolith formation The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti biological_process owl:Class
GO:0031221 biolink:NamedThing arabinan metabolic process The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues. got7fsn_ti arabinan metabolism biological_process owl:Class
GO:0097454 biolink:NamedThing Schwann cell microvillus Small finger-like extension of a Schwann cell that contacts the nodal membrane. got7fsn_ti pr 2012-12-19T13:01:02Z NIF_Subcellular:sao1890444066 cellular_component owl:Class
GO:0102929 biolink:NamedThing lachrymatory factor synthase activity Catalysis of the reaction: 1-propenylsulfenate = propanethiol S-oxide. got7fsn_ti MetaCyc:RXN-8911 molecular_function owl:Class
GO:0001014 biolink:NamedThing snoRNA transcription by RNA polymerase III The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter. got7fsn_ti snoRNA transcription from a type 2 RNA polymerase III promoter krc 2010-08-18T07:13:45Z biological_process owl:Class
GO:0048106 biolink:NamedThing establishment of thoracic bristle planar orientation Orientation along the body surface of bristles, sensory organs originating from a sensory organ precursor cell, such that they all point in a uniform direction. got7fsn_ti establishment of body bristle planar orientation biological_process owl:Class
GO:0099593 biolink:NamedThing endocytosed synaptic vesicle to endosome fusion Fusion of an endocytosed synaptic vesicle with an endosome. got7fsn_ti biological_process owl:Class
GO:0008300 biolink:NamedThing isoprenoid catabolic process The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. got7fsn_ti polyisoprenoid breakdown|isoprenoid catabolism|polyisoprenoid catabolic process|isoprenoid degradation|polyisoprenoid degradation|polyisoprenoid catabolism|polyterpene catabolic process|isoprenoid breakdown|polyterpene catabolism GO:0016097 biological_process owl:Class
GO:0008473 biolink:NamedThing ornithine cyclodeaminase activity Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+). got7fsn_ti ornithine cyclase (deaminating) activity|ornithine cyclase activity|L-ornithine ammonia-lyase (cyclizing; L-proline-forming)|L-ornithine ammonia-lyase (cyclizing)|OCD activity Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases. KEGG_REACTION:R00671|MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN|RHEA:24368|EC:4.3.1.12 molecular_function owl:Class
GO:0033327 biolink:NamedThing Leydig cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis. got7fsn_ti biological_process owl:Class
GO:0050832 biolink:NamedThing defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. got7fsn_ti defense response to fungi|defense response to fungus, incompatible interaction|response to parasitic fungi|response to parasitic fungus|resistance response to pathogenic fungi|defence response to fungi|defence response to fungus|resistance response to pathogenic fungus GO:0009817|GO:0042831|GO:0009623 biological_process owl:Class
GO:0110115 biolink:NamedThing Cdr2 medial cortical node complex A megadalton-sized complex at the medial cortex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent localization and phosphorylation of Wee1 during interphase. got7fsn_ti interphase cortical node|interphase node kmv 2018-07-10T14:02:26Z cellular_component owl:Class
GO:0090402 biolink:NamedThing oncogene-induced cell senescence A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family. got7fsn_ti OIS tb 2011-01-05T02:37:57Z biological_process owl:Class
GO:0090398 biolink:NamedThing cellular senescence A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest. got7fsn_ti tb 2011-01-05T02:27:08Z biological_process owl:Class
GO:0010229 biolink:NamedThing inflorescence development The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0015069 biolink:NamedThing scyllo-inosamine-4-phosphate amidinotransferase activity Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine. got7fsn_ti L-arginine:inosamine-P-amidinotransferase activity|inosamine-P amidinotransferase activity|L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity|L-arginine:inosamine phosphate amidinotransferase activity|inosamine-phosphate amidinotransferase activity KEGG_REACTION:R03477|MetaCyc:2.1.4.2-RXN|RHEA:13265|EC:2.1.4.2 molecular_function owl:Class
GO:0015067 biolink:NamedThing amidinotransferase activity Catalysis of the reversible transfer of an amidino group to an acceptor. got7fsn_ti transamidinase activity EC:2.1.4.- molecular_function owl:Class
GO:0046884 biolink:NamedThing follicle-stimulating hormone secretion The regulated release of follicle-stimulating hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. got7fsn_ti follicle stimulating hormone secretion|FSH secretion|follitropin secretion biological_process owl:Class
GO:0050916 biolink:NamedThing sensory perception of sweet taste The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti sweet taste perception biological_process owl:Class
GO:0000012 biolink:NamedThing single strand break repair The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. got7fsn_ti biological_process owl:Class
GO:0032431 biolink:NamedThing activation of phospholipase A2 activity Any process that initiates the activity of the inactive enzyme phospholipase A2. got7fsn_ti phospholipase A2 activation biological_process owl:Class
GO:0032430 biolink:NamedThing positive regulation of phospholipase A2 activity Any process that activates or increases the activity of the enzyme phospholipase A2. got7fsn_ti up-regulation of phospholipase A2 activity|up regulation of phospholipase A2 activity|activation of phospholipase A2 activity|upregulation of phospholipase A2 activity|stimulation of phospholipase A2 activity biological_process owl:Class
GO:0034948 biolink:NamedThing 2,6-dihydroxypseudooxynicotine hydrolase activity Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate. got7fsn_ti EC:3.7.1.-|UM-BBD_reactionID:r0482 molecular_function owl:Class
GO:0014894 biolink:NamedThing response to denervation involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation. got7fsn_ti biological_process owl:Class
GO:0014877 biolink:NamedThing response to muscle inactivity involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation. got7fsn_ti biological_process owl:Class
GO:0061447 biolink:NamedThing endocardial cushion cell fate specification The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. got7fsn_ti dph 2012-03-13T09:25:56Z biological_process owl:Class
GO:0030758 biolink:NamedThing 3,7-dimethylquercitin 4'-O-methyltransferase activity Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+). got7fsn_ti flavonol 4'-methyltransferase activity|flavonol 4'-O-methyltransferase activity|4'-OMT activity|S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity|3,7-dimethylquercetin 4'-O-methyltransferase activity|S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity EC:2.1.1.83|RHEA:21832|KEGG_REACTION:R03456|MetaCyc:2.1.1.83-RXN molecular_function owl:Class
GO:0120067 biolink:NamedThing pyloric sphincter smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum. got7fsn_ti krc 2017-06-13T22:38:26Z biological_process owl:Class
GO:0042886 biolink:NamedThing amide transport The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0102065 biolink:NamedThing patchoulene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> diphosphoric acid + gamma-patchoulene. got7fsn_ti MetaCyc:RXN-10602 molecular_function owl:Class
GO:0008112 biolink:NamedThing nicotinamide N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine. got7fsn_ti nicotinamide methyltransferase activity|S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN|KEGG_REACTION:R01269|RHEA:23884|EC:2.1.1.1|Reactome:R-HSA-5359451 molecular_function owl:Class
GO:0106233 biolink:NamedThing glycosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a glycosome, a membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis. got7fsn_ti glycosome biogenesis|glycosome organisation|glycosome organization and biogenesis hjd 2019-11-01T18:29:46Z biological_process owl:Class
GO:0042203 biolink:NamedThing toluene catabolic process The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products. got7fsn_ti toluene breakdown|toluene catabolism|toluene degradation biological_process owl:Class
GO:0050638 biolink:NamedThing taxadien-5-alpha-ol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate. got7fsn_ti acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase activity|taxadienol acetyltransferase activity|taxadien-5a-ol O-acetyltransferase activity|taxadien-5alpha-ol O-acetyltransferase activity|acetyl-CoA:taxa-4(20),11-dien-5alpha-ol O-acetyltransferase activity|acetyl coenzyme A:taxa-4(20),11(12)-dien-5-alpha-ol O-acetyl transferase activity|taxa-4(20),11(12)-dien-5alpha-ol-O-acetyltransferase activity KEGG_REACTION:R06307|MetaCyc:2.3.1.162-RXN|RHEA:22028|EC:2.3.1.162 molecular_function owl:Class
GO:0102504 biolink:NamedThing luteolinidin 5-O-glucosyltransferase activity Catalysis of the reaction: luteolinidin + UDP-alpha-D-glucose <=> luteolinidin 5-O-glucoside + UDP + 2 H+. got7fsn_ti MetaCyc:RXN-14424 molecular_function owl:Class
GO:1990654 biolink:NamedThing sebum secreting cell proliferation The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum. got7fsn_ti sebocyte proliferation hjd 2015-02-23T19:43:49Z biological_process owl:Class
GO:0015669 biolink:NamedThing gas transport The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0002176 biolink:NamedThing male germ cell proliferation The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population. got7fsn_ti hjd 2010-11-18T02:35:14Z biological_process owl:Class
GO:0048509 biolink:NamedThing regulation of meristem development Any process that modulates the frequency, rate or extent of meristem development, the biological process whose specific outcome is the progression of the meristem over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0034485 biolink:NamedThing phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate. got7fsn_ti MetaCyc:RXN-10036|Reactome:R-HSA-1675949|RHEA:25528 molecular_function owl:Class
GO:0070458 biolink:NamedThing cellular detoxification of nitrogen compound Any cellular process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. got7fsn_ti cellular detoxification of nitrogenous compound biological_process owl:Class
GO:0051410 biolink:NamedThing detoxification of nitrogen compound Any process that reduces or removes the toxicity of nitrogenous compounds which are dangerous or toxic. This includes the aerobic conversion of toxic compounds to harmless substances. got7fsn_ti nitric oxide (NO) detoxification|detoxification of nitrogenous compound biological_process owl:Class
GO:0042596 biolink:NamedThing fear response The response of an organism to a perceived external threat. got7fsn_ti physiological fear response GO:0001663 biological_process owl:Class
GO:0102550 biolink:NamedThing 2-methyl-6-geranylgeranyl-1,4-benzoquinol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol <=> S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H+. got7fsn_ti MetaCyc:RXN-14917|EC:2.1.1.295|RHEA:38007 molecular_function owl:Class
GO:0036362 biolink:NamedThing ascus membrane A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi. got7fsn_ti bf 2012-09-21T11:21:41Z cellular_component owl:Class
GO:0097069 biolink:NamedThing cellular response to thyroxine stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus. got7fsn_ti cellular response to T4 stimulus pr 2011-06-14T05:06:48Z biological_process owl:Class
GO:0043036 biolink:NamedThing starch grain Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped. got7fsn_ti starch granule cellular_component owl:Class
GO:0015606 biolink:NamedThing spermidine transmembrane transporter activity Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0047882 biolink:NamedThing estradiol 6-beta-monooxygenase activity Catalysis of the reaction: AH(2) + estradiol-17beta + O(2) = 6beta-hydroxyestradiol-17beta + A + H(2)O. got7fsn_ti estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)|estradiol 6b-hydroxylase activity|estradiol 6beta-hydroxylase activity|estradiol 6b-monooxygenase activity|estradiol 6beta-monooxygenase activity|estradiol 6-beta-hydroxylase activity RHEA:19137|MetaCyc:ESTRADIOL-6-BETA-MONOOXYGENASE-RXN|KEGG_REACTION:R03086|EC:1.14.99.11 molecular_function owl:Class
GO:0140570 biolink:NamedThing extraction of mislocalized protein from mitochondrial outer membrane The removal of a mislocalized protein from the mitochondrial outer membrane. got7fsn_ti extraction of mislocalized protein from outer mitochondrion membrane https://github.com/geneontology/go-ontology/issues/20237 pg 2020-12-15T07:37:12Z biological_process owl:Class
GO:0034782 biolink:NamedThing dimethylmalonate decarboxylase activity Catalysis of the reaction: dimethylmalonate + H+ = isobutyrate + CO2. got7fsn_ti UM-BBD_reactionID:r1031 molecular_function owl:Class
GO:0006749 biolink:NamedThing glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. got7fsn_ti oxidized glutathione reduction|glutathione metabolism biological_process owl:Class
GO:0102668 biolink:NamedThing liquiritigenin,NADPH:oxygen oxidoreductase activity Catalysis of the reaction: liquiritigenin + NADPH + O2 + H+ <=> 2,4',7-trihydroxyisoflavanone + NADP(3-) + H2O. got7fsn_ti EC:1.14.14.87|MetaCyc:RXN-3283|RHEA:31723 molecular_function owl:Class
GO:0035362 biolink:NamedThing protein-DNA ISRE complex assembly The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA. got7fsn_ti protein-DNA interferon-stimulated response element complex assembly bf 2010-03-10T10:40:09Z biological_process owl:Class
GO:0018051 biolink:NamedThing C-terminal peptidyl-tryptophan amidation The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0098 biological_process owl:Class
GO:0061160 biolink:NamedThing regulation of establishment of bipolar cell polarity regulating cell shape Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity that contributes to the shape of a cell. got7fsn_ti dph 2010-06-23T09:21:36Z biological_process owl:Class
GO:2000100 biolink:NamedThing regulation of establishment or maintenance of bipolar cell polarity regulating cell shape Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. got7fsn_ti dph 2010-09-14T04:44:57Z biological_process owl:Class
GO:0070999 biolink:NamedThing detection of mechanical stimulus involved in sensory perception of gravity The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal. got7fsn_ti mah 2009-11-03T03:27:30Z biological_process owl:Class
GO:1900567 biolink:NamedThing chanoclavine-I aldehyde metabolic process The chemical reactions and pathways involving chanoclavine-I aldehyde. got7fsn_ti chanoclavine-I aldehyde metabolism di 2012-05-15T06:31:00Z biological_process owl:Class
GO:0031318 biolink:NamedThing detection of folic acid The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal. got7fsn_ti folic acid detection|detection of folate|folic acid sensing|folate sensing|folate detection biological_process owl:Class
GO:0003730 biolink:NamedThing mRNA 3'-UTR binding Binding to a 3' untranslated region of an mRNA molecule. got7fsn_ti mRNA 3' UTR binding molecular_function owl:Class
GO:0000489 biolink:NamedThing maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0106251 biolink:NamedThing N4-acetylcytidine amidohydrolase activity Catalysis of the reaction N4-acetylcytidine +H2O = cytidine + acetate. got7fsn_ti hjd 2020-02-19T20:31:17Z RHEA:62932 molecular_function owl:Class
GO:0009413 biolink:NamedThing response to flooding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water. got7fsn_ti Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle. biological_process owl:Class
GO:0036204 biolink:NamedThing abieta-7,13-dien-18-ol hydroxylase activity Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O. got7fsn_ti bf 2012-04-24T02:37:15Z EC:1.14.14.145|MetaCyc:RXN-12799|RHEA:26221|KEGG_REACTION:R06354 molecular_function owl:Class
GO:0008735 biolink:NamedThing carnitine dehydratase activity Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O. got7fsn_ti L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]|L-carnitine hydro-lyase activity|L-carnitine dehydratase activity EC:4.2.1.89|KEGG_REACTION:R01925|MetaCyc:CARNDEHYDRA-RXN|RHEA:14577 molecular_function owl:Class
GO:0097479 biolink:NamedThing synaptic vesicle localization Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location. got7fsn_ti establishment and maintenance of synaptic vesicle position|establishment and maintenance of synaptic vesicle localization|synaptic vesicle localisation pr 2013-05-22T14:29:55Z biological_process owl:Class
GO:0051648 biolink:NamedThing vesicle localization Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location. got7fsn_ti establishment and maintenance of vesicle localization|cytoplasmic vesicle localization|vesicle localisation biological_process owl:Class
GO:0035718 biolink:NamedThing macrophage migration inhibitory factor binding Binding to the cytokine, macrophage migration inhibitory factor. got7fsn_ti MIF binding bf 2011-03-03T04:27:16Z molecular_function owl:Class
GO:0047726 biolink:NamedThing iron-cytochrome-c reductase activity Catalysis of the reaction: ferrocytochrome c + Fe3+ = ferricytochrome c + Fe2+. got7fsn_ti iron-cytochrome c reductase activity|ferrocytochrome-c:Fe3+ oxidoreductase activity EC:1.9.98.1|MetaCyc:IRON--CYTOCHROME-C-REDUCTASE-RXN|RHEA:15617 molecular_function owl:Class
GO:0072346 biolink:NamedThing cADPR-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts. got7fsn_ti mah 2010-11-10T01:10:51Z molecular_function owl:Class
GO:0070860 biolink:NamedThing RNA polymerase I core factor complex A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p. got7fsn_ti Note that, although this complex can be considered analogous to the mammalian transcription factor SL complex, the core factor complex does not include TBP, whereas SL1 does. mah 2009-08-14T05:00:44Z cellular_component owl:Class
GO:0034005 biolink:NamedThing germacrene-A synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (+)-(R)-germacrene A + diphosphate. got7fsn_ti GAS|2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (germacrene-A-forming) activity|germacrene A synthase activity|2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-A-forming] activity|(+)-germacrene A synthase activity|(+)-(10R)-germacrene A synthase activity RHEA:12516|KEGG_REACTION:R07649|MetaCyc:4.2.3.23-RXN|EC:4.2.3.23 molecular_function owl:Class
GO:0075118 biolink:NamedThing modulation by symbiont of host G protein-coupled receptor signal transduction Any process in which the symbiont modulates the frequency, rate or extent of the host G protein-coupled receptor signal transduction. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host signal transduction mediated by G-protein gamma subunit|modulation by symbiont of host G-protein coupled receptor protein signal transduction|modulation by symbiont of host signal transduction mediated by G-protein beta subunit|modulation by symbiont of host signal transduction mediated by G-protein alpha subunit Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "modulation by host of symbiont G protein-coupled receptor signal transduction ; GO:0075087". GO:0075127|GO:0075124|GO:0075121 biological_process owl:Class
GO:0043852 biolink:NamedThing monomethylamine methyltransferase activity Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3. got7fsn_ti MMAMT|MtmB|monomethylamine:corrinoid methyltransferase activity This function is the first step in the pathway of methanogenesis from monomethylamine. RHEA:26059|MetaCyc:RXN-8098|EC:2.1.1.248 molecular_function owl:Class
GO:0043871 biolink:NamedThing delta1-piperideine-6-carboxylate dehydrogenase activity Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. got7fsn_ti PIPOX|AmaB This function is part of the pipecolate pathway of lysine catabolism. MetaCyc:RXN-8162|RHEA:49476 molecular_function owl:Class
GO:0018299 biolink:NamedThing iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide. got7fsn_ti iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide RESID:AA0225 biological_process owl:Class
GO:0003418 biolink:NamedThing growth plate cartilage chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage. got7fsn_ti dph 2009-12-22T09:00:56Z biological_process owl:Class
GO:0019597 biolink:NamedThing (R)-mandelate catabolic process to benzoate The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate. got7fsn_ti (R)-mandelate degradation to benzoate|(R)-mandelate breakdown to benzoate biological_process owl:Class
GO:0019596 biolink:NamedThing mandelate catabolic process The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic. got7fsn_ti mandelate degradation|mandelate breakdown|mandelate catabolism biological_process owl:Class
GO:1990663 biolink:NamedThing dihydroorotate dehydrogenase (fumarate) activity Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate. got7fsn_ti al 2015-02-26T15:47:30Z EC:1.3.98.1|RHEA:30059 molecular_function owl:Class
GO:0004152 biolink:NamedThing dihydroorotate dehydrogenase activity Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate. got7fsn_ti (S)-dihydroorotate:quinone oxidoreductase activity|(DHO) dehydrogenase activity|DHOdehase activity|dihydoorotic acid dehydrogenase activity|dihydroorotate:ubiquinone oxidoreductase activity Reactome:R-HSA-73569|EC:1.3.5.2|RHEA:18073|MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN|KEGG_REACTION:R01868 molecular_function owl:Class
GO:0034698 biolink:NamedThing response to gonadotropin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus. got7fsn_ti response to gonadotropin stimulus biological_process owl:Class
GO:0030632 biolink:NamedThing D-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid. got7fsn_ti D-alanine synthesis|D-alanine anabolism|D-alanine formation|D-alanine biosynthesis biological_process owl:Class
GO:0044163 biolink:NamedThing host cytoskeleton Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. got7fsn_ti jl 2009-08-11T04:27:04Z cellular_component owl:Class
GO:0044788 biolink:NamedThing modulation by host of viral process A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected. got7fsn_ti jl 2013-06-06T10:50:49Z biological_process owl:Class
GO:0055116 biolink:NamedThing entry into reproductive diapause The dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. got7fsn_ti biological_process owl:Class
GO:0150137 biolink:NamedThing interleukin-37 production The appearance of interleukin-37 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-37 biosynthetic process bc 2019-12-08T08:43:09Z biological_process owl:Class
GO:1900733 biolink:NamedThing negative regulation of polyketide biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of polyketide biosynthetic process. got7fsn_ti inhibition of polyketide formation|down regulation of polyketide synthesis|down-regulation of polyketide synthesis|negative regulation of polyketide anabolism|negative regulation of polyketide biosynthesis|downregulation of polyketide biosynthesis|down-regulation of polyketide biosynthetic process|downregulation of polyketide biosynthetic process|down-regulation of polyketide anabolism|down-regulation of polyketide formation|inhibition of polyketide biosynthesis|inhibition of polyketide biosynthetic process|downregulation of polyketide synthesis|down regulation of polyketide anabolism|down regulation of polyketide formation|negative regulation of polyketide synthesis|downregulation of polyketide anabolism|inhibition of polyketide anabolism|downregulation of polyketide formation|down-regulation of polyketide biosynthesis|inhibition of polyketide synthesis|negative regulation of polyketide formation|down regulation of polyketide biosynthesis|down regulation of polyketide biosynthetic process di 2012-05-26T01:30:02Z biological_process owl:Class
GO:0090071 biolink:NamedThing negative regulation of ribosome biogenesis Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. got7fsn_ti tb 2009-09-11T10:32:17Z biological_process owl:Class
GO:0090117 biolink:NamedThing endosome to lysosome transport of low-density lipoprotein particle The directed movement of low-density lipoprotein particle from endosomes to lysosomes. got7fsn_ti endosome to lysosome transport of LDL tb 2009-12-07T12:04:34Z biological_process owl:Class
GO:0008333 biolink:NamedThing endosome to lysosome transport The directed movement of substances from endosomes to lysosomes. got7fsn_ti biological_process owl:Class
GO:0050292 biolink:NamedThing steroid 9-alpha-monooxygenase activity Catalysis of the reaction: AH(2) + O(2) + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H(2)O. got7fsn_ti steroid 9-alpha-hydroxylase activity|steroid 9a-monooxygenase activity|steroid 9alpha-hydroxylase activity|steroid,hydrogen-donor:oxygen oxidoreductase (9-epoxidizing)|steroid 9alpha-monooxygenase activity RHEA:19557|EC:1.14.99.24|MetaCyc:STEROID-9-ALPHA-MONOOXYGENASE-RXN|KEGG_REACTION:R04392 molecular_function owl:Class
GO:0071430 biolink:NamedThing pre-miRNA-containing ribonucleoprotein complex export from nucleus The directed movement of a ribonucleoprotein complex that contains pre-microRNA from the nucleus to the cytoplasm. got7fsn_ti pre-microRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm|pre-microRNA-containing ribonucleoprotein complex nucleus export|pre-microRNA-containing RNP export from nucleus|pre-microRNA-containing ribonucleoprotein complex export from nucleus|pre-microRNA-containing ribonucleoprotein complex export from cell nucleus mah 2009-12-16T10:26:16Z biological_process owl:Class
GO:0046563 biolink:NamedThing methanol oxidase activity Catalysis of the reaction: O2 + methanol = H2O2 + formaldehyde. got7fsn_ti Note that EC:1.1.3.31 was deleted from EC as it cannot be distinguished from alcohol oxidase (EC:1.1.3.13). MetaCyc:METHANOL-OXIDASE-RXN|EC:1.1.3.- molecular_function owl:Class
GO:0018579 biolink:NamedThing protocatechuate 4,5-dioxygenase activity Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde. got7fsn_ti protocatechuic 4,5-oxygenase activity|protocatechuic 4,5-dioxygenase activity|protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)|protocatechuate 4,5-oxygenase activity UM-BBD_reactionID:r0144|RHEA:24044|MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN|EC:1.13.11.8 molecular_function owl:Class
GO:0039643 biolink:NamedThing host cell viral nucleoid The region of a host cell that contains the viral genome. got7fsn_ti To annotate the region of the complete virus particle in which the viral genome is contained, instead use 'virion nucleoid ; GO:0039642'. bf 2012-09-07T15:41:18Z cellular_component owl:Class
GO:0035553 biolink:NamedThing oxidative single-stranded RNA demethylation Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. got7fsn_ti oxidative ssRNA demethylation bf 2010-05-14T11:05:17Z biological_process owl:Class
GO:0035370 biolink:NamedThing UBC13-UEV1A complex A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A). got7fsn_ti bf 2010-03-11T10:53:09Z cellular_component owl:Class
GO:0060329 biolink:NamedThing cytoplasmic actin-based contraction involved in rearward cell motility The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the rear of the cell. got7fsn_ti cytoplasmic actin-based contraction involved in rearward cell locomotion biological_process owl:Class
GO:0070636 biolink:NamedThing nicotinic acid riboside hydrolase activity Catalysis of the reaction: nicotinic acid riboside + H2O = nicotinic acid + D-ribose. got7fsn_ti nicotinate riboside hydrolase activity|D-ribosylnicotinate hydrolase activity|nicotinate ribonucleoside hydrolase activity|D-ribosylnicotinic acid hydrolase activity|nicotinic acid ribonucleoside hydrolase activity mah 2009-05-07T02:12:00Z molecular_function owl:Class
GO:0036489 biolink:NamedThing neuromelanin biosynthetic process The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers. got7fsn_ti neuromelanin formation|neuromelanin anabolism|neuromelanin biosynthesis|neuromelanin synthesis bf 2014-11-06T13:21:46Z biological_process owl:Class
GO:0016320 biolink:NamedThing endoplasmic reticulum membrane fusion The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum. got7fsn_ti ER membrane fusion biological_process owl:Class
GO:0098583 biolink:NamedThing learned vocalization behavior A vocalization behavior that is the result of learning. got7fsn_ti Examples include human speech and learned bird song. dos 2014-01-24T12:48:57Z biological_process owl:Class
GO:0098598 biolink:NamedThing learned vocalization behavior or vocal learning Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned. got7fsn_ti This grouping term is necessary because, in the absence of conditional mutations, it is not possible to use phenotypic evidence to distinguish an effect on vocal learning from an effect on learned vocalisation behavior. dos 2014-04-10T11:34:33Z biological_process owl:Class
GO:0120192 biolink:NamedThing tight junction assembly A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. got7fsn_ti occluding junction assembly|occluding cell junction assembly krc 2018-08-14T22:48:05Z biological_process owl:Class
GO:0007043 biolink:NamedThing cell-cell junction assembly The aggregation, arrangement and bonding together of a set of components to form a junction between cells. got7fsn_ti intercellular junction assembly biological_process owl:Class
GO:0005868 biolink:NamedThing cytoplasmic dynein complex Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains. got7fsn_ti cytoplasmic dynein heavy chain|cytoplasmic dynein intermediate chain|cytoplasmic dynein light chain|cytoplasmic dynein intermediate light chain Note that this term is labelled based on phylogenetic classification and community usage, rather than strict cellular localization. Cytoplasmic dynein complexes may contain ciliary dyneins; therefore the term is not linked to 'cytoplasm'. Cytoplasmic dynein complexes do not contain axonemal dyneins; see GO:0005858 axonemal dynein complex. cellular_component owl:Class
GO:0140062 biolink:NamedThing 5-formylcytosine dioxygenase activity Catalysis of the reaction: 5-formylcytosine+ 2-oxoglutarate + O2 = 5-carboxylcytosine + succinate + CO2. got7fsn_ti 5fC dioxygenase pg 2017-07-20T09:57:16Z molecular_function owl:Class
GO:0103055 biolink:NamedThing gibberelli A15, 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A15 + 2-oxoglutarate + O2 <=> gibberellin A24 + succinate + carbon dioxide + H2O. got7fsn_ti MetaCyc:RXN1F-163|RHEA:60780 molecular_function owl:Class
GO:0043718 biolink:NamedThing 2-hydroxymethylglutarate dehydrogenase activity Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH. got7fsn_ti (S)-2-hydroxymethylglutarate:NAD+ oxidoreductase activity|HgD MetaCyc:1.1.1.291-RXN|RHEA:15505|KEGG_REACTION:R07985|Wikipedia:2-hydroxymethylglutarate_dehydrogenase|EC:1.1.1.291 molecular_function owl:Class
GO:0052313 biolink:NamedThing modulation of nutrient release from other organism involved in symbiotic interaction Any process in which an organism modulates the frequency, rate or extent of the release of nutrients from a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modulation of nutrient release from other organism during symbiotic interaction biological_process owl:Class
GO:0033190 biolink:NamedThing solanapyrone synthase activity Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A. got7fsn_ti molecular_function owl:Class
GO:0005169 biolink:NamedThing neurotrophin TRKB receptor binding Binding to a neurotrophin TRKB receptor. got7fsn_ti neurotrophin TRKB receptor ligand molecular_function owl:Class
GO:0032289 biolink:NamedThing central nervous system myelin formation The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system. got7fsn_ti myelin formation in central nervous system biological_process owl:Class
GO:0004375 biolink:NamedThing glycine dehydrogenase (decarboxylating) activity Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. got7fsn_ti glycine cleavage system P-protein activity|glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)|protein P1|glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)|glycine-cleavage complex|P-protein|glycine-cleavage complex P-protein activity|glycine decarboxylase activity EC:1.4.4.2|Reactome:R-HSA-5693967|MetaCyc:GCVP-RXN|RHEA:24304 molecular_function owl:Class
GO:0090113 biolink:NamedThing regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. got7fsn_ti tb 2009-12-06T09:16:14Z biological_process owl:Class
GO:0060628 biolink:NamedThing regulation of ER to Golgi vesicle-mediated transport Any process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. got7fsn_ti dph 2009-05-18T02:37:00Z biological_process owl:Class
GO:0000340 biolink:NamedThing RNA 7-methylguanosine cap binding Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. got7fsn_ti RNA m7G cap binding molecular_function owl:Class
GO:0061437 biolink:NamedThing renal system vasculature development The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure. got7fsn_ti dph 2012-03-08T12:16:24Z biological_process owl:Class
GO:0047856 biolink:NamedThing dihydrocoumarin hydrolase activity Catalysis of the reaction: 3,4-dihydrocoumarin + H(2)O = 3-(2-hydroxyphenyl)propanoate + H(+). got7fsn_ti dihydrocoumarin lactonohydrolase activity|dihydrocoumarin lipase activity KEGG_REACTION:R03692|RHEA:10360|EC:3.1.1.35|MetaCyc:DIHYDROCOUMARIN-LIPASE-RXN molecular_function owl:Class
GO:0036331 biolink:NamedThing avascular cornea development in camera-type eye The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees. got7fsn_ti avascular cornea development bf 2012-09-05T09:07:14Z biological_process owl:Class
GO:0045483 biolink:NamedThing aristolochene synthase activity Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate. got7fsn_ti sesquiterpene cyclase activity|trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)|2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, aristolochene-forming)|trans,trans-farnesyl diphosphate aristolochene-lyase activity MetaCyc:ARISTOLOCHENE-SYNTHASE-RXN|RHEA:19825|EC:4.2.3.9 molecular_function owl:Class
GO:0015035 biolink:NamedThing protein-disulfide reductase activity Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. got7fsn_ti haem lyase disulphide oxidoreductase activity|peptide disulfide oxidoreductase activity|protein disulfide oxidoreductase activity|protein disulphide oxidoreductase activity|peptide disulphide oxidoreductase activity|protein disulfide-oxidoreductase activity|heme lyase disulfide oxidoreductase activity https://github.com/geneontology/go-ontology/issues/20219 GO:0008895|GO:0015037 Reactome:R-HSA-3299753|MetaCyc:DISULFOXRED-RXN|Reactome:R-HSA-1307802 molecular_function owl:Class
GO:0008765 biolink:NamedThing UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate. got7fsn_ti UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)|UDP-N-acetylmuramyl-tripeptide synthetase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity|MurE synthetase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity RHEA:23676|KEGG_REACTION:R02788|EC:6.3.2.13|MetaCyc:UDP-NACMURALGLDAPLIG-RXN molecular_function owl:Class
GO:0043230 biolink:NamedThing extracellular organelle Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi. got7fsn_ti cellular_component owl:Class
GO:0034479 biolink:NamedThing phosphatidylglycerol phospholipase C activity Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate. got7fsn_ti molecular_function owl:Class
GO:0046570 biolink:NamedThing methylthioribulose 1-phosphate dehydratase activity Catalysis of the reaction: S-methyl-5-thio-D-ribulose 1-phosphate = 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O. got7fsn_ti 1-PMT-ribulose dehydratase activity|methylthioribulose-1-phosphate dehydratase activity|S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]|5-methylthioribulose-1-phosphate 4-dehydratase activity|S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase[5-(methylthio)-2,3-dioxopentyl-phosphate-forming]|S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase activity GO:0043809 KEGG_REACTION:R07392|MetaCyc:R145-RXN|Reactome:R-HSA-1237140|EC:4.2.1.109|RHEA:15549 molecular_function owl:Class
GO:0097467 biolink:NamedThing type III terminal bouton Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones. got7fsn_ti type III terminal button pr 2013-02-06T09:39:18Z cellular_component owl:Class
GO:0007204 biolink:NamedThing positive regulation of cytosolic calcium ion concentration Any process that increases the concentration of calcium ions in the cytosol. got7fsn_ti cytoplasmic calcium ion concentration elevation|elevation of cytoplasmic calcium ion concentration|elevation of calcium ion concentration in cytosol|cytosolic calcium ion concentration elevation|elevation of calcium ion concentration in cytoplasm|elevation of cytosolic calcium ion concentration biological_process owl:Class
GO:0047152 biolink:NamedThing methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity Catalysis of the reaction: 5-hydroxybenzimidazolylcobamide + methanol = H2O + Co-methyl-Co-5-hydroxybenzimidazolylcob(I)amide. got7fsn_ti methanol-corrinoid protein Co-methyltransferase|methanol:5-hydroxybenzimidazolylcobamide methyltransferase activity|MT 1|methanol cobalamin methyltransferase activity|methyltransferase 1|methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase activity|methanol:corrinoid methyltransferase activity|MT1|MtaB This function is the first step in the pathway of methanogenesis from methanol. GO:1990087 MetaCyc:2.1.1.90-RXN|RHEA:21344|EC:2.1.1.90 molecular_function owl:Class
GO:0010266 biolink:NamedThing response to vitamin B1 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus. got7fsn_ti response to thiamine|response to thiamin biological_process owl:Class
GO:0051643 biolink:NamedThing endoplasmic reticulum localization Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti ER localization|endoplasmic reticulum localisation|establishment and maintenance of ER localization biological_process owl:Class
GO:1900510 biolink:NamedThing negative regulation of pentose catabolic process to ethanol Any process that stops, prevents or reduces the frequency, rate or extent of pentose catabolic process to ethanol. got7fsn_ti down-regulation of pentose catabolism to ethanol|down regulation of pentose catabolism to ethanol|down-regulation of pentose catabolic process to ethanol|negative regulation of pentose catabolism to ethanol|downregulation of pentose catabolic process to ethanol|inhibition of pentose catabolism to ethanol|downregulation of pentose catabolism to ethanol|down regulation of pentose catabolic process to ethanol|inhibition of pentose catabolic process to ethanol tt 2012-05-02T04:04:51Z biological_process owl:Class
GO:0050868 biolink:NamedThing negative regulation of T cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation. got7fsn_ti downregulation of T cell activation|down-regulation of T cell activation|negative regulation of T lymphocyte activation|down regulation of T cell activation|negative regulation of T-cell activation|negative regulation of T-lymphocyte activation|inhibition of T cell activation biological_process owl:Class
GO:0047315 biolink:NamedThing kynurenine-glyoxylate transaminase activity Catalysis of the reaction: L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine. got7fsn_ti kynurenine-glyoxylate aminotransferase activity|kynurenine--glyoxylate aminotransferase activity|L-kynurenine:glyoxylate aminotransferase (cyclizing) EC:2.6.1.63|KEGG_REACTION:R01957|MetaCyc:2.6.1.63-RXN|RHEA:19249 molecular_function owl:Class
GO:0036137 biolink:NamedThing kynurenine aminotransferase activity Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid. got7fsn_ti L-kynurenine transaminase activity|kynurenine-oxo-acid transaminase activity bf 2012-03-06T02:16:48Z molecular_function owl:Class
GO:0042935 biolink:NamedThing achromobactin transport The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0050164 biolink:NamedThing oxoglutarate dehydrogenase (NADP+) activity Catalysis of the reaction: 2-oxoglutarate + CoA + NADP(+) = CO(2) + NADPH + succinyl-CoA. got7fsn_ti 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating) EC:1.2.1.52|RHEA:21400|MetaCyc:OXOGLUTARATE-DEHYDROGENASE-NADP+-RXN|KEGG_REACTION:R00265 molecular_function owl:Class
GO:0034601 biolink:NamedThing oxoglutarate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: 2-oxoglutarate + CoA + NAD(P)+ = succinyl-CoA + CO2 + NAD(P)H. got7fsn_ti EC:1.2.1.52 molecular_function owl:Class
GO:0102971 biolink:NamedThing phosphinothricin N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + phosphinothricin <=> H+ + coenzyme A(4-) + N-acetylphosphinatothricinate. got7fsn_ti RHEA:12597|MetaCyc:RXN-9382|EC:2.3.1.183 molecular_function owl:Class
GO:0034839 biolink:NamedThing menth-2-enone hydratase activity Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone. got7fsn_ti UM-BBD_reactionID:r1184 molecular_function owl:Class
GO:0098653 biolink:NamedThing centromere clustering The process by which centromeres/kinetochores become localized to clusters. got7fsn_ti kinetochore clustering As inner kinetochores are an integral part of centromeres, we treat centromere and kinetochore clustering as the same process. dos 2014-05-23T19:03:37Z GO:0098587 biological_process owl:Class
GO:0019166 biolink:NamedThing trans-2-enoyl-CoA reductase (NADPH) activity Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+. got7fsn_ti reductase, trans-enoyl coenzyme A|acyl-CoA:NADP+ trans-2-oxidoreductase activity|NADPH-dependent trans-2-enoyl-CoA reductase activity Reactome:R-HSA-6786720|Reactome:R-HSA-8952873|Reactome:R-HSA-6809810|RHEA:33763|EC:1.3.1.38|MetaCyc:TRANSENOYLCOARED-RXN molecular_function owl:Class
GO:0005847 biolink:NamedThing mRNA cleavage and polyadenylation specificity factor complex A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. got7fsn_ti CPF complex|cleavage and polyadenylylation specificity factor activity|CFII complex|CPSF complex cellular_component owl:Class
GO:0005849 biolink:NamedThing mRNA cleavage factor complex Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. got7fsn_ti cellular_component owl:Class
GO:0031961 biolink:NamedThing cortisol receptor binding Binding to a cortisol receptor. got7fsn_ti molecular_function owl:Class
GO:0035259 biolink:NamedThing glucocorticoid receptor binding Binding to a glucocorticoid receptor. got7fsn_ti molecular_function owl:Class
GO:0018894 biolink:NamedThing dibenzo-p-dioxin metabolic process The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern. got7fsn_ti dibenzo-p-dioxin metabolism|phenodioxin metabolic process|phenodioxin metabolism|oxanthrene metabolism|oxanthrene metabolic process UM-BBD_pathwayID:dpd biological_process owl:Class
GO:0005199 biolink:NamedThing structural constituent of cell wall The action of a molecule that contributes to the structural integrity of a cell wall. got7fsn_ti molecular_function owl:Class
GO:0030999 biolink:NamedThing linear element assembly The cell cycle process in which linear elements are assembled in association with fission yeast chromosomes during meiotic prophase. Linear element assembly begins with LinE complex formation and ends when LinE complexes are associated with chromatin in structures visible as nuclear foci. A linear element is a proteinaceous scaffold related to the synaptonemal complex. got7fsn_ti linear element formation biological_process owl:Class
GO:0044384 biolink:NamedThing host outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell. got7fsn_ti host cell outer membrane This term covers the outer membrane of the host cell envelope or the outer membrane of a host organelle. For the outer layer of the host cell envelope specifically, see host cell outer membrane ; GO:0039662. jl 2011-12-13T04:02:07Z cellular_component owl:Class
GO:0047172 biolink:NamedThing shikimate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: shikimate + coumaroyl-CoA = 4-coumaroylshikimate + CoA. got7fsn_ti shikimate hydroxycinnamoyltransferase activity|4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase activity EC:2.3.1.133|RHEA:12124|MetaCyc:2.3.1.133-RXN molecular_function owl:Class
GO:0008346 biolink:NamedThing larval walking behavior The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg. got7fsn_ti larval walking behaviour biological_process owl:Class
GO:0035283 biolink:NamedThing central nervous system segmentation Division of the central nervous system into a series of semi-repetitive parts or segments. got7fsn_ti biological_process owl:Class
GO:0102001 biolink:NamedThing isoleucine N-monooxygenase (oxime forming) activity Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ <=> (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O. got7fsn_ti RHEA:28602|MetaCyc:1.14.13.117-RXN|EC:1.14.14.39 molecular_function owl:Class
GO:0050617 biolink:NamedThing 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. got7fsn_ti PebA EC:1.3.7.2|RHEA:10168|MetaCyc:1.3.7.2-RXN molecular_function owl:Class
GO:0061919 biolink:NamedThing process utilizing autophagic mechanism A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway. got7fsn_ti dph 2017-07-13T19:42:14Z biological_process owl:Class
GO:0010385 biolink:NamedThing double-stranded methylated DNA binding Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. got7fsn_ti molecular_function owl:Class
GO:0044203 biolink:NamedThing host cell nuclear lamina The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments. got7fsn_ti jl 2009-10-21T11:11:56Z cellular_component owl:Class
GO:0006588 biolink:NamedThing activation of tryptophan 5-monooxygenase activity The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity. got7fsn_ti tryptophan hydroxylase activation biological_process owl:Class
GO:0032770 biolink:NamedThing positive regulation of monooxygenase activity Any process that activates or increases the activity of a monooxygenase. got7fsn_ti activation of monooxygenase activity|up-regulation of monooxygenase activity|stimulation of monooxygenase activity|up regulation of monooxygenase activity|upregulation of monooxygenase activity biological_process owl:Class
GO:0102858 biolink:NamedThing 1-18:2-2-18:3-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:2-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8325 molecular_function owl:Class
GO:0047554 biolink:NamedThing 2-pyrone-4,6-dicarboxylate lactonase activity Catalysis of the reaction: 2-oxo-2H-pyran-4,6-dicarboxylate + H(2)O = 4-carboxy-2-hydroxyhexa-2,4-dienedioate + H(+). got7fsn_ti 2-pyrone-4,6-dicarboxylate lactonohydrolase activity EC:3.1.1.57|KEGG_REACTION:R04277|RHEA:10644|MetaCyc:RXN-2462 molecular_function owl:Class
GO:0043980 biolink:NamedThing histone H2B-K12 acetylation The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone. got7fsn_ti histone H2B acetylation at K12 biological_process owl:Class
GO:0035199 biolink:NamedThing salt aversion The specific avoidance actions or reactions of an organism in response to the perception of salt. got7fsn_ti behavioral response to salt biological_process owl:Class
GO:1990384 biolink:NamedThing hyaloid vascular plexus regression The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression. got7fsn_ti hjd 2014-05-28T18:43:21Z biological_process owl:Class
GO:0009038 biolink:NamedThing undecaprenol kinase activity Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate. got7fsn_ti ATP:undecaprenol phosphotransferase activity|C55-isoprenyl alcohol phosphokinase activity|C55-isoprenoid alcohol phosphokinase activity|isoprenoid alcohol kinase activity|C55-isoprenoid alcohol kinase activity|isoprenoid alcohol phosphokinase activity|polyisoprenol kinase activity|isoprenoid-alcohol kinase activity|isoprenoid alcohol kinase (phosphorylating) EC:2.7.1.66 molecular_function owl:Class
GO:0004574 biolink:NamedThing oligo-1,6-glucosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose. got7fsn_ti limit dextrinase|exo-oligo-1,6-glucosidase activity|sucrase-isomaltase activity|alpha-limit dextrinase activity|dextrin 6alpha-glucanohydrolase activity|isomaltase activity|oligosaccharide alpha-1,6-glucohydrolase activity|alpha-methylglucosidase activity|oligosaccharide alpha-1,6-glucosidase activity|dextrin 6-glucanohydrolase activity EC:3.2.1.10|MetaCyc:3.2.1.10-RXN molecular_function owl:Class
GO:0072555 biolink:NamedThing 17-beta-ketosteroid reductase activity Catalysis of the reaction: a 17-beta-ketosteroid + NADPH + H+ = a 17-beta-hydroxysteroid + NADP+. got7fsn_ti 7beta-ketosteroid reductase activity|17-beta-ketosteroid reductase (NADPH) activity mah 2011-01-27T11:36:14Z molecular_function owl:Class
GO:0034514 biolink:NamedThing mitochondrial unfolded protein response The series of molecular signals generated as a consequence of the presence of unfolded proteins in the mitochondrial matrix; results in transcriptional upregulation of nuclear genes encoding mitochondrial stress proteins. got7fsn_ti mtUPR biological_process owl:Class
GO:0031774 biolink:NamedThing leukotriene receptor binding Binding to a leukotriene receptor. got7fsn_ti leukotriene receptor ligand molecular_function owl:Class
GO:1902181 biolink:NamedThing verruculogen biosynthetic process The chemical reactions and pathways resulting in the formation of verruculogen. got7fsn_ti verruculogen synthesis|verruculogen formation|verruculogen anabolism|verruculogen biosynthesis di 2013-05-30T17:44:35Z biological_process owl:Class
GO:0047498 biolink:NamedThing calcium-dependent phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. got7fsn_ti calcium-dependent cytosolic phospholipase A2 activity|calcium-dependent secreted phospholipase A2 activity Reactome:R-HSA-111883 molecular_function owl:Class
GO:0018037 biolink:NamedThing C-terminal peptidyl-aspartic acid amidation The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0084 biological_process owl:Class
GO:0018302 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide RESID:AA0284 biological_process owl:Class
GO:0006896 biolink:NamedThing Golgi to vacuole transport The directed movement of substances from the Golgi to the vacuole. got7fsn_ti Golgi to vacuole vesicle-mediated transport biological_process owl:Class
GO:0046974 biolink:NamedThing histone methyltransferase activity (H3-K9 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein. got7fsn_ti histone lysine N-methyltransferase activity (H3-K9 specific)|histone methylase activity (H3-K9 specific) Reactome:R-HSA-427336|Reactome:R-HSA-427527 molecular_function owl:Class
GO:0061976 biolink:NamedThing temporomandibular joint articular cartilage development The process whose specific outcome is the progression of temporomandibular joint articular cartilage over time, from its formation to the mature structure. got7fsn_ti dph 2018-02-12T20:01:00Z biological_process owl:Class
GO:0061975 biolink:NamedThing articular cartilage development The process whose specific outcome is the progression of articular cartilage over time, from its formation to the mature structure. got7fsn_ti articular cartilage of joint development dph 2018-02-12T19:57:31Z biological_process owl:Class
GO:0047774 biolink:NamedThing cis-2-enoyl-CoA reductase (NADPH) activity Catalysis of the reaction: acyl-CoA + NADP+ = cis-2,3-dehydroacyl-CoA + NADPH. got7fsn_ti NADPH-dependent cis-enoyl-CoA reductase activity|reductase, cis-2-enoyl coenzyme A|acyl-CoA:NADP+ cis-2-oxidoreductase activity|cis-2-enoyl-coenzyme A reductase activity MetaCyc:CIS-2-ENOYL-COA-REDUCTASE-NADPH-RXN|EC:1.3.1.37 molecular_function owl:Class
GO:0003879 biolink:NamedThing ATP phosphoribosyltransferase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. got7fsn_ti phosphoribosyladenosine triphosphate synthetase activity|phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity|adenosine triphosphate phosphoribosyltransferase activity|phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity|phosphoribosyladenosine triphosphate pyrophosphorylase activity|1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity|phosphoribosyl-ATP diphosphorylase activity|phosphoribosyl-ATP pyrophosphorylase activity|phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity|phosphoribosyl ATP synthetase activity MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN|RHEA:18473|EC:2.4.2.17 molecular_function owl:Class
GO:0050007 biolink:NamedThing isonocardicin synthase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H(+) + isonocardicin A. got7fsn_ti nocardicin aminocarboxypropyltransferase activity|S-adenosyl-L-methionine:nocardicin-E 3-amino-3-carboxypropyltransferase activity MetaCyc:ISONOCARDICIN-SYNTHASE-RXN|KEGG_REACTION:R03072|EC:2.5.1.38|RHEA:19845 molecular_function owl:Class
GO:0018542 biolink:NamedThing 2,3-dihydroxy DDT 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0452 molecular_function owl:Class
GO:0090495 biolink:NamedThing low-density lipoprotein particle disassembly The disaggregation of a low-density lipoprotein particle into its constituent components. got7fsn_ti tb 2012-10-17T11:48:56Z biological_process owl:Class
GO:0034518 biolink:NamedThing RNA cap binding complex Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. got7fsn_ti cellular_component owl:Class
GO:0008277 biolink:NamedThing regulation of G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway. got7fsn_ti regulation of G-protein-coupled receptor protein signalling pathway|regulation of G protein coupled receptor protein signalling pathway|regulation of G protein coupled receptor protein signaling pathway|regulation of GPCR protein signaling pathway|regulation of GPCR protein signalling pathway|regulation of G-protein coupled receptor protein signalling pathway|regulation of G-protein coupled receptor protein signaling pathway biological_process owl:Class
GO:0120084 biolink:NamedThing endothelial tip cell filopodium assembly The assembly of a filopodium, a thin, stiff protrusion extended by the endothelial tip cell of a vascular sprout. got7fsn_ti krc 2017-07-07T18:05:10Z biological_process owl:Class
GO:0046847 biolink:NamedThing filopodium assembly The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. got7fsn_ti filopodium formation|filopodia formation|filopodia biosynthesis biological_process owl:Class
GO:0060773 biolink:NamedThing flower phyllotactic patterning The radial pattern formation process that results in the formation of floral organ primordia around a central axis in a flower primordium. got7fsn_ti dph 2009-07-25T06:28:38Z biological_process owl:Class
GO:0030611 biolink:NamedThing arsenate reductase activity Catalysis of the interconversion of arsenate and arsenite. got7fsn_ti molecular_function owl:Class
GO:0039719 biolink:NamedThing tube viral factory A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories. got7fsn_ti bf 2013-12-19T15:34:56Z cellular_component owl:Class
GO:0031532 biolink:NamedThing actin cytoskeleton reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. got7fsn_ti actin cytoskeleton remodeling|actin cytoskeleton reorganisation GO:0007012 biological_process owl:Class
GO:1990863 biolink:NamedThing acinar cell proliferation The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus). got7fsn_ti acinic cell proliferation|acinous cell proliferation sl 2015-09-25T14:26:09Z biological_process owl:Class
GO:0046575 biolink:NamedThing rhamnogalacturonan acetylesterase activity Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan. got7fsn_ti molecular_function owl:Class
GO:0008449 biolink:NamedThing N-acetylglucosamine-6-sulfatase activity Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. got7fsn_ti N-acetylglucosamine 6-sulfate sulfatase activity|chondroitinsulfatase|N-acetylglucosamine-6-sulphatase activity|acetylglucosamine 6-sulfatase activity|2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity|glucosamine-6-sulfatase activity|N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity|O,N-disulfate O-sulfohydrolase activity Reactome:R-HSA-2263495|MetaCyc:3.1.6.14-RXN|EC:3.1.6.14|Reactome:R-HSA-1638032 molecular_function owl:Class
GO:0098617 biolink:NamedThing adenylylselenate kinase activity Catalysis of the reaction: ATP + adenylylselenate => ADP + 3'-phosphoadenylylselenate. got7fsn_ti Reactome:R-HSA-2408540 molecular_function owl:Class
GO:0075196 biolink:NamedThing adhesion of symbiont haustorium mother cell to host The attachment of a haustorium mother cell of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti adhesion of symbiont haustorium mother cell to host during symbiotic interaction Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0102299 biolink:NamedThing linolenate 9R-lipoxygenase activity Catalysis of the reaction: alpha-linolenate + O2 <=> (9R,10E,12Z,15Z)-9-hydroperoxyoctadeca-10,12,15-trienoate. got7fsn_ti RHEA:31687|EC:1.13.11.61|MetaCyc:RXN-12759 molecular_function owl:Class
GO:0004808 biolink:NamedThing tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate. got7fsn_ti tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity|S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity|transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity GO:0016425 RHEA:19569|EC:2.1.1.61|MetaCyc:2.1.1.61-RXN|KEGG_REACTION:R00601 molecular_function owl:Class
GO:0034608 biolink:NamedThing vulval location Location, by the male, of his partner's vulva when backing along the ventral side of the hermaphrodite during mating. The male stops at the vulva, coordinates his movements to the hermaphrodite's, and positions his tail precisely over the vulva so that he may insert his spicules and ejaculate. got7fsn_ti biological_process owl:Class
GO:0031073 biolink:NamedThing cholesterol 26-hydroxylase activity Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol. got7fsn_ti molecular_function owl:Class
GO:0047990 biolink:NamedThing hydroxyglutamate decarboxylase activity Catalysis of the reaction: 3-hydroxy-L-glutamate + H(+) = 4-amino-3-hydroxybutanoate + CO(2). got7fsn_ti 3-hydroxy-L-glutamate 1-carboxy-lyase activity|3-hydroxy-L-glutamate 1-carboxy-lyase (4-amino-3-hydroxybutanoate-forming) KEGG_REACTION:R04135|MetaCyc:HYDROXYGLUTAMATE-DECARBOXYLASE-RXN|RHEA:14073|EC:4.1.1.16 molecular_function owl:Class
GO:0045795 biolink:NamedThing positive regulation of cell volume Any process that increases cell volume. got7fsn_ti biological_process owl:Class
GO:0005358 biolink:NamedThing high-affinity glucose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high-affinity hydrogen:glucose transporter activity|high-affinity hydrogen:glucose symporter activity|high-affinity hydrogen/glucose transporter activity molecular_function owl:Class
GO:0009617 biolink:NamedThing response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. got7fsn_ti response to bacteria GO:0009618|GO:0009680 biological_process owl:Class
GO:0072168 biolink:NamedThing specification of anterior mesonephric tubule identity The process in which the tubules of the anterior mesonephros acquire their identity. got7fsn_ti mah 2010-02-26T01:52:36Z biological_process owl:Class
GO:0018488 biolink:NamedThing aryl-aldehyde oxidase activity Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide. got7fsn_ti aryl-aldehyde:oxygen oxidoreductase activity UM-BBD_reactionID:r0145|MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN|EC:1.2.3.9|RHEA:18569 molecular_function owl:Class
GO:0004031 biolink:NamedThing aldehyde oxidase activity Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide. got7fsn_ti aldehyde:oxygen oxidoreductase activity|quinoline oxidase activity Reactome:R-HSA-3204311|EC:1.2.3.1|MetaCyc:ALDEHYDE-OXIDASE-RXN|RHEA:16829 molecular_function owl:Class
GO:0010258 biolink:NamedThing NADH dehydrogenase complex (plastoquinone) assembly The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I. got7fsn_ti biological_process owl:Class
GO:0010257 biolink:NamedThing NADH dehydrogenase complex assembly The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex. got7fsn_ti biological_process owl:Class
GO:0033942 biolink:NamedThing 4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity Catalysis of the hydrolysis of alpha-(1->4)-D-glucosidic linkage in 4-alpha-D-{(1->4)-alpha-D-glucanosyl}n trehalose to yield trehalose and alpha-(1->4)-D-glucan. got7fsn_ti maltooligosyl trehalose trehalohydrolase activity|4-alpha-D-{(1,4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity|malto-oligosyltrehalose trehalohydrolase activity|4-alpha-D-{(1->4)-alpha-D-glucano}trehalose glucanohydrolase (trehalose-producing) activity MetaCyc:3.2.1.141-RXN|EC:3.2.1.141 molecular_function owl:Class
GO:0019668 biolink:NamedThing anaerobic catabolism of pairs of amino acids The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP. got7fsn_ti Stickland reaction|cofermentation of pairs of amino acids biological_process owl:Class
GO:0018426 biolink:NamedThing O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage. got7fsn_ti O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism|O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation|O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis|O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis RESID:AA0297 biological_process owl:Class
GO:0042757 biolink:NamedThing giant axon Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses. got7fsn_ti cellular_component owl:Class
GO:0047362 biolink:NamedThing thiosulfate-dithiol sulfurtransferase activity Catalysis of the reaction: dithioerythritol + thiosulfate = hydrogen sulfide + dithioerythritol disulfide + sulfite. got7fsn_ti thiosulfate reductase activity|TSR|thiosulfate:dithioerythritol sulfurtransferase activity|thiosulphate-dithiol sulphurtransferase activity RHEA:15121|MetaCyc:2.8.1.5-RXN|EC:2.8.1.5 molecular_function owl:Class
GO:0070877 biolink:NamedThing microprocessor complex A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs. got7fsn_ti mah 2009-08-20T03:56:26Z cellular_component owl:Class
GO:1903095 biolink:NamedThing ribonuclease III complex A protein complex which is capable of ribonuclease III activity. got7fsn_ti An example of this is RNC in human (Q9NRR4) in PMID:22393237 (inferred from direct assay). bhm 2014-06-03T15:06:39Z cellular_component owl:Class
GO:0061684 biolink:NamedThing chaperone-mediated autophagy The autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded. got7fsn_ti CMA|chaperone-assisted selective autophagy|CASA https://github.com/geneontology/go-ontology/issues/20850 dph 2015-03-04T14:35:26Z Wikipedia:Chaperone-mediated_autophagy biological_process owl:Class
GO:0071912 biolink:NamedThing asynchronous neurotransmitter secretion Release of neurotransmitter at the synapse that persists for tens to hundreds of milliseconds after action potential invasion. got7fsn_ti mah 2010-09-22T01:45:35Z biological_process owl:Class
GO:0052813 biolink:NamedThing phosphatidylinositol bisphosphate kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate. got7fsn_ti ai 2011-10-21T03:55:36Z molecular_function owl:Class
GO:0032906 biolink:NamedThing transforming growth factor beta2 production The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti transforming growth factor-beta2 production|TGF-B2 production|TGFB2 production biological_process owl:Class
GO:0052675 biolink:NamedThing 3-methylbutanol:NADP oxidoreductase activity Catalysis of the reaction: 3-methylbutanol + NADP+ = 3-methylbutanal + NADPH + H+. 3-methylbutanal is also known as isovaleraldehyde. got7fsn_ti isoamyl alcohol oxidase (NADP) activity|3-methylbutanol:NADP+ oxidoreductase activity|3-methylbutyraldehyde reductase (NADP) activity|3-methylbutanal reductase (NADP) activity ai 2011-04-12T11:19:27Z KEGG_REACTION:R05686|RHEA:18525 molecular_function owl:Class
GO:0018747 biolink:NamedThing phenanthrene-1,2-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene. got7fsn_ti UM-BBD_reactionID:r0536 molecular_function owl:Class
GO:0019118 biolink:NamedThing phenanthrene-epoxide hydrolase activity Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene. got7fsn_ti EC:3.3.2.- molecular_function owl:Class
GO:0044011 biolink:NamedThing single-species biofilm formation on inanimate substrate A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. got7fsn_ti biological_process owl:Class
GO:0090609 biolink:NamedThing single-species submerged biofilm formation A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription. got7fsn_ti tb 2014-09-16T14:55:15Z biological_process owl:Class
GO:0060722 biolink:NamedThing cell proliferation involved in embryonic placenta development The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta. got7fsn_ti dph 2009-06-12T12:46:04Z biological_process owl:Class
GO:0033972 biolink:NamedThing proclavaminate amidinohydrolase activity Catalysis of the reaction: amidinoproclavaminate + H(2)O = proclavaminate + urea. got7fsn_ti proclavaminic acid amidino hydrolase activity|PAH|proclavaminate amidino hydrolase activity RHEA:17001|KEGG_REACTION:R05357|EC:3.5.3.22|MetaCyc:3.5.3.22-RXN molecular_function owl:Class
GO:0031767 biolink:NamedThing gastric inhibitory polypeptide receptor binding Binding to a gastric inhibitory polypeptide receptor. got7fsn_ti gastric inhibitory polypeptide receptor ligand molecular_function owl:Class
GO:0008503 biolink:NamedThing benzodiazepine receptor activity Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. got7fsn_ti Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. molecular_function owl:Class
GO:0080106 biolink:NamedThing 7-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 7-methylthiopropyl-glucosinolate = 7-methylsulfinylpropyl-glucosinolate. got7fsn_ti dhl 2009-04-23T04:29:37Z molecular_function owl:Class
GO:0047019 biolink:NamedThing indole-3-acetaldehyde reductase (NADPH) activity Catalysis of the reaction: indole-3-ethanol + NADP(+) = (indol-3-yl)acetaldehyde + H(+) + NADPH. got7fsn_ti indoleacetaldehyde (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|indole-3-ethanol:NADP+ oxidoreductase activity|(indol-3-yl)ethanol:NADP+ oxidoreductase activity KEGG_REACTION:R02680|MetaCyc:1.1.1.191-RXN|RHEA:17037|EC:1.1.1.191 molecular_function owl:Class
GO:0060992 biolink:NamedThing response to fungicide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. got7fsn_ti dph 2010-01-13T08:05:58Z biological_process owl:Class
GO:0045480 biolink:NamedThing galactose oxidase activity Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide. got7fsn_ti D-galactose oxidase activity|beta-galactose oxidase activity|D-galactose:oxygen 6-oxidoreductase activity RHEA:24160|EC:1.1.3.9|MetaCyc:GALACTOSE-OXIDASE-RXN molecular_function owl:Class
GO:0102582 biolink:NamedThing cyanidin 3-O-p-coumaroylglucoside 2-O''-xylosyltransferase activity Catalysis of the reaction: cyanidin 3-O-(6-O-(E)-4-coumaroyl-beta-D-glucoside) + UDP-alpha-D-xylose <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-15328 molecular_function owl:Class
GO:0050431 biolink:NamedThing transforming growth factor beta binding Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. got7fsn_ti TGF-beta binding|transforming growth factor beta ligand binding to type II receptor|TGFbeta binding|transforming growth factor beta ligand binding to type I receptor molecular_function owl:Class
GO:0070224 biolink:NamedThing sulfide:quinone oxidoreductase activity Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone. got7fsn_ti sulfide-quinone reductase activity|sulphide:quinone oxidoreductase activity Reactome:R-HSA-1614665|MetaCyc:R17-RXN|RHEA:30239 molecular_function owl:Class
GO:0016672 biolink:NamedThing oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound. got7fsn_ti oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor EC:1.8.5.- molecular_function owl:Class
GO:0046583 biolink:NamedThing cation efflux transmembrane transporter activity Enables the transfer of a cation or cations from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti cation efflux permease activity molecular_function owl:Class
GO:0047459 biolink:NamedThing 3-aminobutyryl-CoA ammonia-lyase activity Catalysis of the reaction: (S)-3-aminobutanoyl-CoA = crotonoyl-CoA + NH(4)(+). got7fsn_ti L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)|L-3-aminobutyryl-CoA ammonia-lyase activity|L-3-aminobutyryl-CoA deaminase activity EC:4.3.1.14|MetaCyc:4.3.1.14-RXN|RHEA:10056|KEGG_REACTION:R03030 molecular_function owl:Class
GO:0036175 biolink:NamedThing ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin. got7fsn_ti bf 2012-03-29T11:12:42Z Reactome:R-HSA-111742|Reactome:R-HSA-8866405 molecular_function owl:Class
GO:0061731 biolink:NamedThing ribonucleoside-diphosphate reductase activity Catalysis of the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. got7fsn_ti ribonucleoside 5'-diphosphate reductase activity|ribonucleotide diphosphate reductase activity|aerobic non-heme iron-dependent ribonucleotide reductase activity|adenosylcobalamin-dependent ribonucleotide reductase activity|RNR|class III ribonucleotide reductase activity|class II ribonucleoside-diphosphate reductase activity|anaerobic iron-sulfur-dependent ribonucleotide reductase activity|class I ribonucleotide reductase activity|purine/pyrimidine nucleoside diphosphate reduction|nucleoside diphosphate reductase activity|ribonucleotide reductase activity|class II ribonucleotide reductase activity dph 2015-08-24T07:25:59Z molecular_function owl:Class
GO:0004984 biolink:NamedThing olfactory receptor activity Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. got7fsn_ti odorant receptor activity molecular_function owl:Class
GO:0007114 biolink:NamedThing cell budding A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell. got7fsn_ti budding biological_process owl:Class
GO:0089713 biolink:NamedThing Cbf1-Met4-Met28 complex A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation. got7fsn_ti cellular_component owl:Class
GO:0043385 biolink:NamedThing mycotoxin metabolic process The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus. got7fsn_ti mycotoxin metabolism biological_process owl:Class
GO:0034475 biolink:NamedThing U4 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U4 snRNA molecule. got7fsn_ti U4 snRNA 3' end processing biological_process owl:Class
GO:0045176 biolink:NamedThing apical protein localization Any process in which a protein is transported to, or maintained in, apical regions of the cell. got7fsn_ti establishment and maintenance of apical protein localization|establishment and maintenance of protein localization in apical part of cell|apical protein localisation biological_process owl:Class
GO:0051498 biolink:NamedThing syn-copalyl diphosphate synthase activity Catalysis of the reaction: geranylgeranyl diphosphate = 9alpha-copalyl diphosphate. got7fsn_ti diterpene cyclase activity EC:5.5.1.14|RHEA:25524|MetaCyc:RXN-8528 molecular_function owl:Class
GO:0047771 biolink:NamedThing carboxymethylhydantoinase activity Catalysis of the reaction: L-5-carboxymethylhydantoin + H(2)O = N-carbamoyl-L-aspartate + H(+). got7fsn_ti hydantoin hydrolase activity|L-5-carboxymethylhydantoin amidohydrolase activity RHEA:12028|MetaCyc:CARBOXYMETHYLHYDANTOINASE-RXN|KEGG_REACTION:R02284|EC:3.5.2.4 molecular_function owl:Class
GO:0018424 biolink:NamedThing peptidyl-glutamic acid poly-ADP-ribosylation This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way. got7fsn_ti RESID:AA0295 biological_process owl:Class
GO:0031088 biolink:NamedThing platelet dense granule membrane The lipid bilayer surrounding the platelet dense granule. got7fsn_ti cellular_component owl:Class
GO:0097111 biolink:NamedThing endoplasmic reticulum-Golgi intermediate compartment organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment. got7fsn_ti ERGIC organization|endoplasmic reticulum-Golgi intermediate compartment organisation|ER-Golgi intermediate compartment organization|endoplasmic reticulum-Golgi intermediate compartment organization and biogenesis pr 2011-07-29T04:45:54Z biological_process owl:Class
GO:0047566 biolink:NamedThing 3-ketovalidoxylamine C-N-lyase activity Catalysis of the reaction: 4-nitrophenyl-3-ketovalidamine = 4-nitroaniline + 5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + H(+). got7fsn_ti 4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase [5-D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one-forming]|3-ketovalidoxylamine A C-N-lyase activity|4-nitrophenyl-3-ketovalidamine 4-nitroaniline-lyase activity|p-nitrophenyl-3-ketovalidamine p-nitroaniline lyase activity MetaCyc:3-KETOVALIDOXYLAMINE-C-N-LYASE-RXN|EC:4.3.3.1|KEGG_REACTION:R04367|RHEA:22768 molecular_function owl:Class
GO:0102800 biolink:NamedThing caffeoyl-CoA:pelargonidin-3,5-diglucoside-6''-O-acyltransferase activity Catalysis of the reaction: anthocyanidin 3,5-di-O-beta-D-glucoside + caffeoyl-CoA = pelargonidin 3-O-(6-O-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside + coenzyme A. got7fsn_ti MetaCyc:RXN-8138 molecular_function owl:Class
GO:0102970 biolink:NamedThing 7-deoxyloganetic acid glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 7-deoxyloganetate <=> H+ + 7-deoxyloganate + UDP. got7fsn_ti RHEA:39895|EC:2.4.1.323|MetaCyc:RXN-9372 molecular_function owl:Class
GO:0018522 biolink:NamedThing benzoyl-CoA reductase activity Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H(2)O + benzoyl-CoA + reduced ferredoxin. got7fsn_ti cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity|benzoyl-CoA reductase (dearomatizing) activity UM-BBD_reactionID:r0190|RHEA:30199|MetaCyc:1.3.99.15-RXN|EC:1.3.7.8|KEGG_REACTION:R02451 molecular_function owl:Class
GO:0050883 biolink:NamedThing musculoskeletal movement, spinal reflex action Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord. got7fsn_ti biological_process owl:Class
GO:0061710 biolink:NamedThing L-threonylcarbamoyladenylate synthase Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H(2)O. got7fsn_ti dph 2015-06-23T08:25:14Z MetaCyc:RXN-14569|RHEA:36407|EC:2.7.7.87 molecular_function owl:Class
GO:0006501 biolink:NamedThing C-terminal protein lipidation The covalent attachment of a lipid group to the carboxy-terminus of a protein. got7fsn_ti biological_process owl:Class
GO:0106028 biolink:NamedThing neuron projection retraction The organization process which results in the disassembly (either partial or complete) of constituent parts of a neuron projection. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. got7fsn_ti neuron projection disassembly hjd 2017-06-23T18:32:42Z biological_process owl:Class
GO:0106027 biolink:NamedThing neuron projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite. got7fsn_ti hjd 2017-06-23T18:30:18Z biological_process owl:Class
GO:0004566 biolink:NamedThing beta-glucuronidase activity Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate. got7fsn_ti exo-beta-D-glucuronidase activity|glucuronidase activity|beta-D-glucuronoside glucuronosohydrolase activity|beta-glucuronide glucuronohydrolase activity|ketodase activity Reactome:R-HSA-2162226|Reactome:R-HSA-9036070|Reactome:R-HSA-2318373|MetaCyc:BETA-GLUCURONID-RXN|Reactome:R-HSA-2162227|RHEA:17633|Reactome:R-HSA-1678854|Reactome:R-HSA-9036068|EC:3.2.1.31 molecular_function owl:Class
GO:0060325 biolink:NamedThing face morphogenesis The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head. got7fsn_ti biological_process owl:Class
GO:0102512 biolink:NamedThing delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside betaine + vanillate + H+. got7fsn_ti EC:2.4.1.299|MetaCyc:RXN-14441 molecular_function owl:Class
GO:0005612 biolink:NamedThing laminin-7 complex A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains. got7fsn_ti laminin-321 complex|laminin-7A cellular_component owl:Class
GO:0046099 biolink:NamedThing guanine biosynthetic process The chemical reactions and pathways resulting in the formation of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. got7fsn_ti guanine formation|guanine biosynthesis|guanine anabolism|guanine synthesis biological_process owl:Class
GO:0036307 biolink:NamedThing 23S rRNA (adenine(2030)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA. got7fsn_ti bf 2012-08-08T14:15:48Z molecular_function owl:Class
GO:0047040 biolink:NamedThing pteridine reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = biopterin + 2 H(+) + 2 NADPH. got7fsn_ti ptr1 activity|pteridine reductase 1 activity|PTR1|5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase activity|dihydrobiopterin reduction Note that this function was formerly EC:1.1.1.253. MetaCyc:1.1.1.253-RXN|EC:1.5.1.33|RHEA:19509|KEGG_REACTION:R01812 molecular_function owl:Class
GO:0102166 biolink:NamedThing [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-L-threonine-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [protein]-L-threonine. got7fsn_ti RHEA:48892|EC:3.2.1.169|MetaCyc:RXN-11891 molecular_function owl:Class
GO:0097621 biolink:NamedThing monoamine oxidase activity Catalysis of the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2. got7fsn_ti amine:oxygen oxidoreductase (deaminating) activity Acts on primary amines, and also on some secondary and tertiary amines. It differs from EC:1.4.3.21, primary-amine oxidase as it can oxidize secondary and tertiary amines but not methylamine. pr 2014-07-30T10:23:57Z RHEA:26414 molecular_function owl:Class
GO:0005715 biolink:NamedThing late recombination nodule An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I. got7fsn_ti cellular_component owl:Class
GO:0005713 biolink:NamedThing recombination nodule An electron dense structure that is associated with meiotic chromosomes. got7fsn_ti cellular_component owl:Class
GO:0033824 biolink:NamedThing alternansucrase activity Catalysis of the transfer of an alpha-D-glucosyl residue from sucrose to alternately the 6-position and the 3-position of the non-reducing terminal residue of an alpha-D-glucan, thus producing a glucan having alternating alpha-1,6- and alpha-1,3-linkages. got7fsn_ti sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity|sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase activity|sucrose-1,6(3)-alpha-glucan 6(3)-alpha-glucosyltransferase activity EC:2.4.1.140|MetaCyc:2.4.1.140-RXN molecular_function owl:Class
GO:0018284 biolink:NamedThing iron incorporation into protein via tetrakis-L-cysteinyl iron The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein). got7fsn_ti RESID:AA0136 biological_process owl:Class
GO:0018742 biolink:NamedThing epoxide hydrolase B activity Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers. got7fsn_ti EC:3.3.2.-|UM-BBD_enzymeID:e0051 molecular_function owl:Class
GO:0035541 biolink:NamedThing negative regulation of SNARE complex disassembly Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. got7fsn_ti bf 2010-05-10T01:42:47Z biological_process owl:Class
GO:0007540 biolink:NamedThing sex determination, establishment of X:A ratio The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it. got7fsn_ti biological_process owl:Class
GO:0102175 biolink:NamedThing 3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity Catalysis of the reaction: a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH. got7fsn_ti MetaCyc:RXN-11928|RHEA:34775 molecular_function owl:Class
GO:0032588 biolink:NamedThing trans-Golgi network membrane The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. got7fsn_ti Golgi trans face membrane|trans Golgi network membrane cellular_component owl:Class
GO:0042287 biolink:NamedThing MHC protein binding Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. got7fsn_ti major histocompatibility complex ligand|major histocompatibility complex binding Note that this term does not include binding to the antigen peptide bound to the MHC protein, for this also annotate to 'peptide antigen binding ; GO:0042605' or one of its children. molecular_function owl:Class
GO:2000934 biolink:NamedThing negative regulation of cellotriose metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellotriose metabolic process. got7fsn_ti negative regulation of cellotriose metabolism tt 2011-08-01T12:44:20Z biological_process owl:Class
GO:0080006 biolink:NamedThing internode patterning Determines the spacing between two shoot nodes. A shoot node is the region of the shoot where the spikelet, flower, floret, branch, bud and/or leaves are attached. got7fsn_ti biological_process owl:Class
GO:0002085 biolink:NamedThing inhibition of neuroepithelial cell differentiation Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells. got7fsn_ti negative regulation of neural plate formation|repression of premature neural plate formation biological_process owl:Class
GO:0110008 biolink:NamedThing ncRNA deadenylation Shortening of the poly(A) tail of a nuclear-transcribed ncRNA. got7fsn_ti kmv biological_process owl:Class
GO:0060543 biolink:NamedThing negative regulation of strand invasion Any process that decreases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. got7fsn_ti negative regulation of D-loop biosynthesis|negative regulation of D-loop formation|negative regulation of Rad51-mediated strand invasion dph 2009-04-13T01:32:36Z biological_process owl:Class
GO:0047006 biolink:NamedThing 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity Catalysis of the reaction: NAD(P)+ + 17-alpha,20-alpha-dihydroxypregn-4-en-3-one = NAD(P)H + H+ + 17-alpha-hydroxyprogesterone. got7fsn_ti 20alpha-hydroxy steroid dehydrogenase activity|20alpha-HSDH|20alpha-hydroxysteroid:NAD(P)+ 20-oxidoreductase activity|20alpha-hydroxysteroid dehydrogenase|20alpha-HSD MetaCyc:1.1.1.149-RXN|EC:1.1.1.149 molecular_function owl:Class
GO:0015068 biolink:NamedThing glycine amidinotransferase activity Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate. got7fsn_ti L-arginine:glycine amidinotransferase activity|arginine-glycine amidinotransferase activity|arginine-glycine transamidinase activity|glycine transamidinase activity RHEA:13201|Reactome:R-HSA-71275|EC:2.1.4.1|MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN molecular_function owl:Class
GO:0072243 biolink:NamedThing metanephric nephron epithelium development The process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros. got7fsn_ti mah 2010-03-19T03:29:49Z biological_process owl:Class
GO:0019712 biolink:NamedThing peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid The methyl esterification of peptidyl-glutamic acid. got7fsn_ti peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid|peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid|peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid RESID:AA0072 biological_process owl:Class
GO:0070179 biolink:NamedThing D-serine biosynthetic process The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine. got7fsn_ti D-serine anabolism|D-serine formation|D-serine biosynthesis|D-serine synthesis biological_process owl:Class
GO:0010961 biolink:NamedThing cellular magnesium ion homeostasis Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell. got7fsn_ti tb 2009-05-06T11:48:45Z biological_process owl:Class
GO:0102520 biolink:NamedThing L-threonine O-3-phosphate phosphatase activity Catalysis of the reaction: O-phospho-L-threonine + H2O = L-threonine + hydrogenphosphate. got7fsn_ti MetaCyc:RXN-14505 molecular_function owl:Class
GO:0005940 biolink:NamedThing septin ring A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. got7fsn_ti GO:0030481 Wikipedia:Septin_ring cellular_component owl:Class
GO:0044582 biolink:NamedThing butyryl-CoA catabolic process to butanol The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol. got7fsn_ti butyryl-CoA catabolism to butanol jl 2012-04-19T04:40:06Z biological_process owl:Class
GO:0071271 biolink:NamedThing 1-butanol biosynthetic process The chemical reactions and pathways resulting in the formation of 1-butanol, an alkyl primary alcohol with the formula C4H10O. got7fsn_ti butanol biosynthetic process|1-butanol biosynthesis|1-butanol formation|butan-1-ol biosynthetic process|1-butanol anabolism|1-butanol synthesis mah 2009-12-10T10:27:24Z biological_process owl:Class
GO:0047924 biolink:NamedThing geraniol dehydrogenase activity Catalysis of the reaction: geraniol + NADP+ = geranial + NADPH. got7fsn_ti geraniol:NADP+ oxidoreductase activity MetaCyc:GERANIOL-DEHYDROGENASE-RXN|UM-BBD_reactionID:r1163|EC:1.1.1.183|RHEA:14521 molecular_function owl:Class
GO:0120031 biolink:NamedThing plasma membrane bounded cell projection assembly Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon. got7fsn_ti eupodium https://github.com/geneontology/go-ontology/issues/13298 krc 2017-04-24T23:56:08Z biological_process owl:Class
GO:0080118 biolink:NamedThing brassinosteroid sulfotransferase activity Catalysis of the reaction: a brassinosteroid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated brassinosteroid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a brassinosteroid acceptor, producing the sulfated brassinosteroid derivative. got7fsn_ti dhl 2009-04-27T03:39:36Z molecular_function owl:Class
GO:0031874 biolink:NamedThing type 3 proteinase activated receptor binding Binding to a type 3 proteinase activated receptor. got7fsn_ti type 3 proteinase activated receptor ligand molecular_function owl:Class
GO:0048383 biolink:NamedThing mesectoderm development The process whose specific outcome is the progression of the mesectoderm over time, from its formation to the mature structure. In animal embryos, mesectoderm development processes give rise to both mesoderm and ectoderm tissues. got7fsn_ti biological_process owl:Class
GO:0016996 biolink:NamedThing endo-alpha-(2,8)-sialidase activity Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids. got7fsn_ti endo-N-acylneuraminidase activity|endoneuraminidase activity|polysialoside (2->8)-alpha-sialosylhydrolase activity|alpha-2,8-sialosylhydrolase activity|poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity|poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity|endosialidase activity|endo-N-acetylneuraminidase activity EC:3.2.1.129|MetaCyc:3.2.1.129-RXN molecular_function owl:Class
GO:0042044 biolink:NamedThing fluid transport The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0050624 biolink:NamedThing vomilenine reductase activity Catalysis of the reaction: 1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine. got7fsn_ti 1,2-dihydrovomilenine:NADP+ oxidoreductase activity MetaCyc:1.5.1.32-RXN|KEGG_REACTION:R05878|RHEA:16409|EC:1.5.1.32 molecular_function owl:Class
GO:0032611 biolink:NamedThing interleukin-1 beta production The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-1 beta secretion|interleukin-1 beta biosynthetic process|IL-1 beta production GO:0050702|GO:0050720 biological_process owl:Class
GO:0032612 biolink:NamedThing interleukin-1 production The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-1 production|interleukin-1 biosynthetic process|interleukin-1 secretion GO:0042222|GO:0050701 biological_process owl:Class
GO:0004088 biolink:NamedThing carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate. got7fsn_ti carbamoylphosphate synthetase II activity|carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity|carbamoyl phosphate synthase (glutamine-hydrolyzing) activity|GD-CPSase activity|carbamoyl phosphate synthetase activity|carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity|glutamine-dependent carbamyl phosphate synthetase activity|carbamyl phosphate synthetase (glutamine) activity|carbamoyl-phosphate synthase (glutamine-hydrolysing) activity|hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity|CPS activity|glutamine-dependent carbamoyl-phosphate synthase activity|carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity Reactome:R-HSA-73577|RHEA:18633|MetaCyc:CARBPSYN-RXN|EC:6.3.5.5 molecular_function owl:Class
GO:0140483 biolink:NamedThing kinetochore adaptor activity The binding activity of a protein that brings the kinetochore and another molecule into contact, permitting those molecules to function in a coordinated way. got7fsn_ti inner kinetochore adaptor activity|outer kinetochore adaptor activity https://github.com/geneontology/go-ontology/issues/19701|https://github.com/geneontology/go-ontology/issues/21091 pg 2020-06-29T08:53:10Z molecular_function owl:Class
GO:0046975 biolink:NamedThing histone methyltransferase activity (H3-K36 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group onto lysine at position 36 of the histone H3 protein. got7fsn_ti histone lysine N-methyltransferase activity (H3-K36 specific)|histone methylase activity (H3-K36 specific) molecular_function owl:Class
GO:0050587 biolink:NamedThing chlorite O2-lyase activity Catalysis of the reaction: chloride + O(2) = chlorite. got7fsn_ti chlorite dismutase activity|chloride:oxygen oxidoreductase activity GO:0030065 MetaCyc:1.13.11.49-RXN|KEGG_REACTION:R05721|UM-BBD_reactionID:r0982|RHEA:21404|EC:1.13.11.49 molecular_function owl:Class
GO:0018378 biolink:NamedThing cytochrome c-heme linkage via heme-L-cysteine The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine. got7fsn_ti cytochrome c-haem linkage via haem-L-cysteine RESID:AA0135 biological_process owl:Class
GO:0102117 biolink:NamedThing gibberellin A9 carboxyl methyltransferase activity Catalysis of the reaction: gibberellin A9 + S-adenosyl-L-methionine <=> gibberellin A9 methyl ester + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-11358|EC:2.1.1.275|RHEA:36119 molecular_function owl:Class
GO:0060452 biolink:NamedThing positive regulation of cardiac muscle contraction Any process that increases the frequency, rate or extent of cardiac muscle contraction. got7fsn_ti biological_process owl:Class
GO:0045989 biolink:NamedThing positive regulation of striated muscle contraction Any process that activates or increases the frequency, rate or extent of striated muscle contraction. got7fsn_ti activation of striated muscle contraction|up-regulation of striated muscle contraction|upregulation of striated muscle contraction|up regulation of striated muscle contraction|stimulation of striated muscle contraction biological_process owl:Class
GO:0042161 biolink:NamedThing lipoprotein oxidation The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group. got7fsn_ti biological_process owl:Class
GO:0047757 biolink:NamedThing chondroitin-glucuronate 5-epimerase activity Catalysis of the reaction: chondroitin D-glucuronate = dermatan L-iduronate. got7fsn_ti chondroitin D-glucuronosyl 5-epimerase activity|dermatan-sulfate 5-epimerase activity|polyglucuronate 5-epimerase activity|urunosyl C-5 epimerase activity|chondroitin-D-glucuronate 5-epimerase activity RHEA:21084|Reactome:R-HSA-2022052|MetaCyc:CHONDROITIN-GLUCURONATE-5-EPIMERASE-RXN|EC:5.1.3.19 molecular_function owl:Class
GO:0005631 biolink:NamedThing chitosan layer of spore wall The second outermost layer of the spore wall, as described in Saccharomyces. got7fsn_ti cellular_component owl:Class
GO:0052629 biolink:NamedThing phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. got7fsn_ti Reactome:R-HSA-1676105|EC:3.1.3.95|Reactome:R-HSA-6809778|MetaCyc:RXN-10958|RHEA:39019|Reactome:R-HSA-1676203|Reactome:R-HSA-1676065|Reactome:R-HSA-6809320|Reactome:R-HSA-6809944 molecular_function owl:Class
GO:0097368 biolink:NamedThing establishment of Sertoli cell barrier Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions. got7fsn_ti establishment of BTB|establishment of blood-testis barrier|establishment of SCB pr 2012-08-02T17:05:55Z biological_process owl:Class
GO:0047641 biolink:NamedThing aldose-6-phosphate reductase (NADPH) activity Catalysis of the reaction: D-glucitol 6-phosphate + NADP(+) = D-glucose 6-phosphate + H(+) + NADPH. got7fsn_ti NADP-dependent aldose 6-phosphate reductase activity|NADP-dependent D-sorbitol-6-phosphate dehydrogenase activity|alditol 6-phosphate:NADP 1-oxidoreductase activity|A6PR|aldose-6-phosphate reductase activity|aldose-6-P reductase activity|aldose 6-phosphate reductase activity|D-aldose-6-phosphate:NADP+ 1-oxidoreductase activity EC:1.1.1.200|KEGG_REACTION:R00834|RHEA:20037|MetaCyc:ALDOSE-6-PHOSPHATE-REDUCTASE-NADPH-RXN molecular_function owl:Class
GO:0075031 biolink:NamedThing positive regulation of formation of symbiont germ tube hook structure for appressorium development Any process that activates, maintains or increases the frequency, rate or extent of symbiont germ tube hook structure formation. got7fsn_ti positive regulation of formation of symbiont germ tube hook structure on or near host|positive regulation of symbiont germ tube hook structure formation on or near host|positive regulation of germ tube tip of symbiont on or near the exterior of host biological_process owl:Class
GO:0075027 biolink:NamedThing positive regulation of appressorium initiation Any process that activates or increases the frequency, rate or extent of symbiont appressorium initiation. got7fsn_ti positive regulation of initiation of appressorium on or near host|positive regulation of appressorium initiation on or near host biological_process owl:Class
GO:0006796 biolink:NamedThing phosphate-containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. got7fsn_ti phosphate metabolism|phosphate metabolic process biological_process owl:Class
GO:0097635 biolink:NamedThing extrinsic component of autophagosome membrane The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to autophagic vacuole membrane|autophagic vacuole peripheral membrane|extrinsic component of autophagic vacuole membrane cellular_component owl:Class
GO:0005053 biolink:NamedThing peroxisome matrix targeting signal-2 binding Binding to a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F). got7fsn_ti PTS2 binding|peroxisome targeting signal-2 binding|peroxisomal targeting signal 2 (PTS2) binding|peroxisome targeting signal-2 receptor|PTS2 receptor|PEX7 molecular_function owl:Class
GO:0000268 biolink:NamedThing peroxisome targeting sequence binding Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome. got7fsn_ti PTS receptor|PTS binding|peroxisome targeting signal receptor GO:0005051 molecular_function owl:Class
GO:0044864 biolink:NamedThing positive regulation by virus of host cell division Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division. got7fsn_ti jl 2014-08-05T16:31:20Z biological_process owl:Class
GO:0051781 biolink:NamedThing positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division. got7fsn_ti upregulation of cell division|activation of cell division|up-regulation of cell division|up regulation of cell division|stimulation of cell division biological_process owl:Class
GO:0022032 biolink:NamedThing telencephalon oligodendrocyte cell migration The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class
GO:0050866 biolink:NamedThing negative regulation of cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation. got7fsn_ti down regulation of cell activation|downregulation of cell activation|down-regulation of cell activation|inhibition of cell activation biological_process owl:Class
GO:0050698 biolink:NamedThing proteoglycan sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans. got7fsn_ti proteoglycan sulphotransferase activity|proteoglycan sulfate transfer molecular_function owl:Class
GO:0005790 biolink:NamedThing smooth endoplasmic reticulum The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER. got7fsn_ti smooth ER|SER Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum|NIF_Subcellular:sao710427438 cellular_component owl:Class
GO:0102341 biolink:NamedThing 3-oxo-lignoceroyl-CoA reductase activity Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA + NADP <=> 3-oxotetracosanoyl-CoA + NADPH + H+. got7fsn_ti MetaCyc:RXN-13300|EC:1.1.1.330 molecular_function owl:Class
GO:0001857 biolink:NamedThing complement component C1q receptor activity Combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0001544 biolink:NamedThing initiation of primordial ovarian follicle growth Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle). got7fsn_ti biological_process owl:Class
GO:0015181 biolink:NamedThing arginine transmembrane transporter activity Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane. got7fsn_ti histidine/arginine/lysine/ornithine porter activity|L-arginine transporter activity|arginine permease activity GO:0005288 RHEA:32143 molecular_function owl:Class
GO:0007362 biolink:NamedThing terminal region determination Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products. got7fsn_ti biological_process owl:Class
GO:0060273 biolink:NamedThing crying behavior The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli. got7fsn_ti biological_process owl:Class
GO:0004095 biolink:NamedThing carnitine O-palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. got7fsn_ti carnitine palmitoyltransferase I|outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity|carnitine palmitoyltransferase-A|palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity|CPT-B|acylcarnitine transferase activity|carnitine palmitoyltransferase activity|CPT I (outer membrane carnitine palmitoyl transferase)|L-carnitine palmitoyltransferase activity|CPTo|CPT-A|CPT|carnitine palmitoyltransferase II|palmitoylcarnitine transferase activity|CPTi MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN|Reactome:R-HSA-200410|RHEA:12661|Reactome:R-HSA-200406|EC:2.3.1.21 molecular_function owl:Class
GO:0019142 biolink:NamedThing 2-hydroxyglutarate synthase activity Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+). got7fsn_ti propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)|2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity|hydroxyglutarate synthase activity|alpha-hydroxyglutarate synthase activity|2-hydroxyglutaric synthetase activity|2-hydroxyglutaratic synthetase activity Note that this function was formerly EC:4.1.3.9. KEGG_REACTION:R00932|RHEA:19185|EC:2.3.3.11|MetaCyc:HYDGLUTSYN-RXN molecular_function owl:Class
GO:0021979 biolink:NamedThing hypothalamus cell differentiation The differentiation of cells that will contribute to the structure and function of the hypothalamus. got7fsn_ti biological_process owl:Class
GO:0047742 biolink:NamedThing chenodeoxycholoyltaurine hydrolase activity Catalysis of the reaction: chenodeoxycholoyltaurine + H2O = chenodeoxycholate + taurine. got7fsn_ti chenodeoxycholoyltaurine amidohydrolase activity MetaCyc:CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN|EC:3.5.1.74|RHEA:16309 molecular_function owl:Class
GO:0038018 biolink:NamedThing Wnt receptor catabolic process The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation. got7fsn_ti Wnt receptor catabolism|Wnt receptor degradation|Wnt receptor breakdown|Frizzled degradation|negative regulation of Wnt receptor signaling pathway by Wnt receptor degradation bf 2011-06-23T04:38:12Z biological_process owl:Class
GO:0055060 biolink:NamedThing asymmetric neuroblast division resulting in ganglion mother cell formation Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell. got7fsn_ti biological_process owl:Class
GO:0014017 biolink:NamedThing neuroblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast. got7fsn_ti biological_process owl:Class
GO:0004013 biolink:NamedThing adenosylhomocysteinase activity Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. got7fsn_ti S-adenosyl-L-homocysteine hydrolase activity|S-adenosylhomocysteine hydrolase activity|S-adenosylhomocysteine synthase activity|S-adenosylhomocysteinase activity|AdoHcyase activity|adenosylhomocysteine hydrolase activity|SAHase activity Reactome:R-HSA-5579084|RHEA:21708|MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN|Reactome:R-HSA-174401|EC:3.3.1.1 molecular_function owl:Class
GO:0005020 biolink:NamedThing stem cell factor receptor activity Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation. got7fsn_ti SCF receptor activity|KIT ligand receptor activity|KIT|KL receptor activity molecular_function owl:Class
GO:0050697 biolink:NamedThing 1,1,2-trichloroethene reductive dehalogenase activity Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene. got7fsn_ti TCE-reductive dehalogenase activity|1,1,2-trichloroethylene reductive dehalogenase activity MetaCyc:TCEREDCHLOR-RXN|UM-BBD_enzymeID:e0271 molecular_function owl:Class
GO:0030783 biolink:NamedThing [cytochrome c]-methionine S-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine. got7fsn_ti cytochrome c-methionine S-methyltransferase activity|S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity MetaCyc:2.1.1.123-RXN|EC:2.1.1.123 molecular_function owl:Class
GO:0047487 biolink:NamedThing oligogalacturonide lyase activity Catalysis of the reaction: 4-(4-deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate. got7fsn_ti OGTE|oligogalacturonate lyase activity|unsaturated oligogalacturonate transeliminase activity MetaCyc:OLIGOGALACTURONIDE-LYASE-RXN|EC:4.2.2.6|RHEA:20269 molecular_function owl:Class
GO:0102755 biolink:NamedThing gibberellin-15(closed lactone form),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating) activity Catalysis of the reaction: gibberellin A15 (closed lactone form) + O2 + 2-oxoglutarate = gibberellin A37 (closed lactone form) + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-7680 molecular_function owl:Class
GO:0019424 biolink:NamedThing sulfide oxidation, using siroheme sulfite reductase A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase. got7fsn_ti sulphur oxidation, using siroheme sulphite reductase|sulphide oxidation, using siroheme sulphite reductase|sulfur oxidation, using sirohaem sulfite reductase|sulfide oxidation, using sirohaem sulfite reductase|sulfur oxidation, using siroheme sulfite reductase GO:0019425 MetaCyc:P223-PWY biological_process owl:Class
GO:0120022 biolink:NamedThing glucagon family peptide binding Binding to a member of the glucagon family peptide hormone (e.g. glucagon, glucagon-like peptides, oxyntomodulin, glicentin, ADCYAP1, GHRH, secretin, VIP, GIP). got7fsn_ti glucagon binding|glucagon-like peptide binding https://github.com/geneontology/go-ontology/issues/13143|https://github.com/geneontology/go-ontology/issues/21327 krc 2017-03-17T14:46:29Z GO:0120024 molecular_function owl:Class
GO:0072116 biolink:NamedThing pronephros formation The developmental process pertaining to the initial formation of the pronephros. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life. got7fsn_ti pronephric kidney formation mah 2010-02-22T11:16:26Z biological_process owl:Class
GO:0072003 biolink:NamedThing kidney rudiment formation The developmental process pertaining to the initial formation of a kidney rudiment from unspecified parts. A kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti kidney anlage formation mah 2010-01-25T11:18:58Z biological_process owl:Class
GO:0046175 biolink:NamedThing aldonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group. got7fsn_ti aldonic acid biosynthesis|aldonic acid synthesis|aldonic acid formation|aldonic acid anabolism biological_process owl:Class
GO:0035473 biolink:NamedThing lipase binding Binding to a lipase. got7fsn_ti bf 2010-04-22T05:28:52Z molecular_function owl:Class
GO:0006236 biolink:NamedThing cytidine salvage Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0003011 biolink:NamedThing involuntary skeletal muscle contraction A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control. got7fsn_ti biological_process owl:Class
GO:0097653 biolink:NamedThing unencapsulated part of cell The part of a cell encompassing the intracellular environment and the plasma membrane; it excludes any external encapsulating structures. got7fsn_ti non-encapsulated part of cell pr 2014-09-23T12:57:14Z cellular_component owl:Class
GO:0004598 biolink:NamedThing peptidylamidoglycolate lyase activity Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate. got7fsn_ti HGAD|alpha-hydroxyglycine amidating dealkylase activity|PGL|PAL|peptidylamidoglycolate peptidylamide-lyase activity|peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)|peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN|EC:4.3.2.5|RHEA:20924 molecular_function owl:Class
GO:0098502 biolink:NamedThing DNA dephosphorylation The process of removing one or more phosphate groups from a DNA molecule. got7fsn_ti dos 2013-09-18T14:50:16Z biological_process owl:Class
GO:0010415 biolink:NamedThing unsubstituted mannan metabolic process The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units. got7fsn_ti unsubstituted mannan metabolism biological_process owl:Class
GO:0046983 biolink:NamedThing protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. got7fsn_ti molecular_function owl:Class
GO:0018743 biolink:NamedThing phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene. got7fsn_ti UM-BBD_reactionID:r0560|EC:3.3.2.- molecular_function owl:Class
GO:0019119 biolink:NamedThing phenanthrene-9,10-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene. got7fsn_ti molecular_function owl:Class
GO:0047080 biolink:NamedThing deoxyuridine 2'-dioxygenase activity Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = CO(2) + succinate + uridine. got7fsn_ti thymidine 2-oxoglutarate dioxygenase activity|pyrimidine deoxyribonucleoside 2'-hydroxylase activity|pyrimidine-deoxynucleoside 2'-dioxygenase activity|thymidine 2'-dioxygenase activity|deoxyuridine 2'-hydroxylase activity|2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2'-hydroxylating)|pyrimidine-deoxynucleoside,2-oxoglutarate 2'-dioxygenase activity|thymidine dioxygenase activity|thymidine 2'-hydroxylase activity MetaCyc:1.14.11.3-RXN|RHEA:21076|EC:1.14.11.3|KEGG_REACTION:R01879 molecular_function owl:Class
GO:0043878 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+. got7fsn_ti NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase activity|glyceraldehyde-3-phosphate dehydrogenase (NAD) (non-phosphorylating) activity|glyceraldehyde-3-phosphate dehydrogenase (NAD) activity|non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (NAD) EC:1.2.1.3|MetaCyc:RXN-3443|RHEA:25294 molecular_function owl:Class
GO:0001735 biolink:NamedThing prenylcysteine oxidase activity Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2. got7fsn_ti prenylcysteine lyase activity|S-prenyl-L-cysteine:oxygen oxidoreductase activity RHEA:53892|EC:1.8.3.5|MetaCyc:1.8.3.5-RXN molecular_function owl:Class
GO:0006756 biolink:NamedThing AMP phosphorylation The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP. got7fsn_ti biological_process owl:Class
GO:0047601 biolink:NamedThing acetate kinase (diphosphate) activity Catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate. got7fsn_ti pyrophosphate-acetate phosphotransferase activity|diphosphate:acetate phosphotransferase activity|acetate kinase (pyrophosphate) activity RHEA:24276|EC:2.7.2.12|KEGG_REACTION:R00320|MetaCyc:ACETATE-KINASE-PYROPHOSPHATE-RXN molecular_function owl:Class
GO:0004436 biolink:NamedThing phosphatidylinositol diacylglycerol-lyase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol. got7fsn_ti monophosphatidylinositol phosphodiesterase activity|1-phosphatidylinositol phosphodiesterase activity|1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)|1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)|1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming) Note that this function was formerly EC:3.1.4.10. MetaCyc:3.1.4.10-RXN|RHEA:17093|EC:4.6.1.13 molecular_function owl:Class
GO:0102165 biolink:NamedThing (Z)-3-hexen-1-ol acetyltransferase activity Catalysis of the reaction: acetyl-CoA + (Z)-hex-3-en-1-ol <=> (3Z)-hex-3-en-1-yl acetate + coenzyme A. got7fsn_ti MetaCyc:RXN-11852|EC:2.3.1.195|RHEA:28254 molecular_function owl:Class
GO:0002368 biolink:NamedThing B cell cytokine production Any process that contributes to cytokine production by a B cell. got7fsn_ti B lymphocyte cytokine production|B-lymphocyte cytokine production|B-cell cytokine production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0006705 biolink:NamedThing mineralocorticoid biosynthetic process The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. got7fsn_ti mineralocorticoid formation|mineralocorticoid synthesis|mineralocorticoid biosynthesis|mineralocorticoid anabolism biological_process owl:Class
GO:0050562 biolink:NamedThing lysine-tRNA(Pyl) ligase activity Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP. got7fsn_ti lysine-tRNAPyl ligase activity|L-lysine:tRNAPyl ligase (AMP-forming) MetaCyc:6.1.1.25-RXN molecular_function owl:Class
GO:1990377 biolink:NamedThing organomineral extracellular matrix An extracellular matrix consisting of a densely packed organomineral assembly in which the mineral phase represents the majority of the material by weight. got7fsn_ti An example is found in shell calcitic prisms of the Mediterranean fan mussel Pinna nobilis (PMID:15994301), but the term may also be useful to annotate bone and eggshell proteins. pr 2014-05-07T10:02:28Z cellular_component owl:Class
GO:0043972 biolink:NamedThing histone H3-K23 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone. got7fsn_ti histone H3K23 acetylation|histone H3 acetylation at K23 biological_process owl:Class
GO:0007569 biolink:NamedThing cell aging An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469). got7fsn_ti cell ageing biological_process owl:Class
GO:0048538 biolink:NamedThing thymus development The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. got7fsn_ti Note that this term is reserved for annotation of gene products involved in the formation of the thymus itself, not for gene products involved in T cell differentiation in the thymus or elsewhere. biological_process owl:Class
GO:0061708 biolink:NamedThing tRNA-5-taurinomethyluridine 2-sulfurtransferase Catalysis of 5-taurinomethyluridine in tRNA + a [protein]-S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a [protein]-L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+. got7fsn_ti dph 2015-06-16T09:02:23Z Reactome:R-HSA-6787447|RHEA:47040|MetaCyc:RXN-16821 molecular_function owl:Class
GO:0009799 biolink:NamedThing specification of symmetry The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created. got7fsn_ti determination of symmetry biological_process owl:Class
GO:0039554 biolink:NamedThing suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. got7fsn_ti suppression by virus of host IFIH1 signaling pathway|Inhibition of host MDA5 by virus|suppression by virus of host MDA-5 activity|inhibition by virus of host MDA-5 signaling|inhibition of host IFIH1/MDA5 by virus|suppression by virus of host MDA-5 signaling pathway|suppression by virus of host MDA-5 signalling pathway https://github.com/geneontology/go-ontology/issues/21984 bf 2012-03-09T03:03:49Z GO:0039539 biological_process owl:Class
GO:0018670 biolink:NamedThing 4-aminobenzoate 1-monooxygenase activity Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2. got7fsn_ti 4-aminobenzoate hydroxylase activity|4-aminobenzoate dehydrogenase activity|4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)|4-aminobenzoate monooxygenase activity EC:1.14.13.27|MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN|UM-BBD_reactionID:r0597 molecular_function owl:Class
GO:1990344 biolink:NamedThing secondary cell septum biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division. got7fsn_ti mah 2014-03-24T13:24:48Z biological_process owl:Class
GO:0017116 biolink:NamedThing single-stranded DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. got7fsn_ti ssDNA-dependent ATP-dependent DNA helicase activity|single-stranded DNA-dependent ATPase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity|ssDNA-dependent ATPase activity GO:0043142 molecular_function owl:Class
GO:0097121 biolink:NamedThing cyclin A1-CDK1 complex A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:41:25Z cellular_component owl:Class
GO:0019116 biolink:NamedThing hydroxy-nicotine oxidase activity Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide. got7fsn_ti EC:1.5.3.6 molecular_function owl:Class
GO:0050664 biolink:NamedThing oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. got7fsn_ti oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor EC:1.6.3.- molecular_function owl:Class
GO:0030487 biolink:NamedThing inositol-4,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. got7fsn_ti molecular_function owl:Class
GO:0050555 biolink:NamedThing 2-hydroxypropyl-CoM lyase activity Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane. got7fsn_ti epoxypropyl:CoM transferase activity|epoxyalkane:2-mercaptoethanesulfonate transferase activity|(R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; epoxyalkane-ring-forming)|epoxypropane:coenzyme M transferase activity|(R)-[or (S)-]2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)|2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming)|coenzyme M-epoxyalkane ligase activity|epoxyalkane:CoM transferase activity|EaCoMT activity|epoxyalkane:coenzyme M transferase activity|epoxyalkyl:CoM transferase activity MetaCyc:4.2.99.19-RXN|EC:4.4.1.23|RHEA:19421|UM-BBD_enzymeID:e0538 molecular_function owl:Class
GO:0062140 biolink:NamedThing hyphae septin collar A septin collar in pathogenic fungi involved in the constriction of hyphae at the plant plasmodesma enabling penetration of an adjacent cell. got7fsn_ti septin collar of invasive hyphae https://github.com/geneontology/go-ontology/issues/19013 dph 2019-08-06T14:31:04Z cellular_component owl:Class
GO:0032173 biolink:NamedThing septin collar A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell. got7fsn_ti septin hourglass https://github.com/geneontology/go-ontology/issues/19534 cellular_component owl:Class
GO:0102007 biolink:NamedThing acyl-L-homoserine-lactone lactonohydrolase activity Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine. got7fsn_ti RHEA:22576|EC:3.1.1.81|MetaCyc:3.1.1.81-RXN|Reactome:R-HSA-8932633 molecular_function owl:Class
GO:0046573 biolink:NamedThing lactonohydrolase activity Catalysis of the hydrolysis of lactone rings (intramolecular cyclic esters) to produce a hydroxyl group and a carboxyl group. got7fsn_ti molecular_function owl:Class
GO:0009420 biolink:NamedThing bacterial-type flagellum filament The long (approximately 20 nm), thin external structure of the bacterial-type flagellum, which acts as a propeller. got7fsn_ti flagellin-based flagellum filament|flagellar filament cellular_component owl:Class
GO:0033757 biolink:NamedThing glucoside 3-dehydrogenase activity Catalysis of the reaction: sucrose + acceptor = 3-dehydro-alpha-D-glucosyl-beta-D-fructofuranoside + reduced acceptor. got7fsn_ti D-aldohexoside:acceptor 3-oxidoreductase|D-aldohexopyranoside dehydrogenase|hexopyranoside-cytochrome c oxidoreductase|D-aldohexoside:cytochrome c oxidoreductase|D-aldohexoside:(acceptor) 3-oxidoreductase MetaCyc:GLUCOSIDE-3-DEHYDROGENASE-RXN|Wikipedia:Glucoside_3-dehydrogenase|RHEA:16589|EC:1.1.99.13 molecular_function owl:Class
GO:0071366 biolink:NamedThing cellular response to indolebutyric acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an indolebutyric acid stimulus. got7fsn_ti cellular response to IBA stimulus|cellular response to indole-3-butyric acid stimulus mah 2009-12-11T03:12:14Z biological_process owl:Class
GO:0009374 biolink:NamedThing biotin binding Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. got7fsn_ti vitamin H binding|vitamin B7 binding molecular_function owl:Class
GO:0008390 biolink:NamedThing testosterone 16-alpha-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O. got7fsn_ti cytochrome P450 CYP2D11|cytochrome P450 CYP2D10|cytochrome P450 CYP2B10|cytochrome P450 CYP2B9|cytochrome P450 CYP2D9 molecular_function owl:Class
GO:0008479 biolink:NamedThing queuine tRNA-ribosyltransferase activity Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. got7fsn_ti transfer ribonucleate glycosyltransferase activity|queuine transfer ribonucleate ribosyltransferase activity|Q-insertase activity|tRNA guanine transglycosidase activity|guanine, queuine-tRNA transglycosylase activity|tRNA-guanine transglycosylase activity|tRNA transglycosylase activity|guanine insertion enzyme activity|[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN|RHEA:16633|Reactome:R-HSA-6782443|EC:2.4.2.29 molecular_function owl:Class
GO:0102450 biolink:NamedThing kaempferide 7-O-methyltransferase activity Catalysis of the reaction: kaempferide + S-adenosyl-L-methionine <=> 7,4'-dimethylkaempferol + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13936 molecular_function owl:Class
GO:0072736 biolink:NamedThing cellular response to tert-butyl hydroperoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus. got7fsn_ti cellular response to 2-methyl-prop-2-yl-hydroperoxide|cellular response to t-BOOH mah 2012-07-17T10:33:00Z biological_process owl:Class
GO:0071817 biolink:NamedThing MMXD complex A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation. got7fsn_ti MMS19-MIP18-XPD complex mah 2010-09-07T10:53:42Z cellular_component owl:Class
GO:0044472 biolink:NamedThing envenomation resulting in modulation of calcium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism. got7fsn_ti jl 2012-01-19T02:17:25Z biological_process owl:Class
GO:0008884 biolink:NamedThing glutathionylspermidine amidase activity Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine. got7fsn_ti gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity|GSP amidase activity|glutathionylspermidine amidohydrolase (spermidine-forming) activity EC:3.5.1.78|MetaCyc:GSPAMID-RXN|RHEA:17173 molecular_function owl:Class
GO:0016268 biolink:NamedThing O-glycan processing, core 2 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc. got7fsn_ti biological_process owl:Class
GO:0002701 biolink:NamedThing negative regulation of production of molecular mediator of immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response. got7fsn_ti down regulation of production of molecular mediator of immune response|downregulation of production of molecular mediator of immune response|inhibition of production of molecular mediator of immune response|down-regulation of production of molecular mediator of immune response biological_process owl:Class
GO:0086054 biolink:NamedThing bundle of His cell to Purkinje myocyte communication by electrical coupling The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels. got7fsn_ti bundle of His cardiac muscle cell to Purkinje myocyte communication by electrical coupling dph 2011-11-17T10:46:43Z biological_process owl:Class
GO:0055081 biolink:NamedThing anion homeostasis Any process involved in the maintenance of an internal steady state of anions within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0045508 biolink:NamedThing interleukin-26 receptor activity Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-26 receptor activity|IL-26R molecular_function owl:Class
GO:0005129 biolink:NamedThing granulocyte macrophage colony-stimulating factor receptor binding Binding to a granulocyte macrophage colony-stimulating factor receptor. got7fsn_ti granulocyte macrophage colony-stimulating factor receptor ligand|GMC-SF receptor ligand|GM-CSF receptor ligand|granulocyte macrophage colony stimulating factor receptor binding|GM-CSF receptor binding|granulocyte macrophage colony-stimulating factor molecular_function owl:Class
GO:0010613 biolink:NamedThing positive regulation of cardiac muscle hypertrophy Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. got7fsn_ti biological_process owl:Class
GO:0097713 biolink:NamedThing dolichol-phosphate-mannose synthase regulator activity Binds to and modulates the activity of dolichol-phosphate-mannose synthase. got7fsn_ti pr 2016-08-23T11:19:37Z molecular_function owl:Class
GO:0042667 biolink:NamedThing auditory receptor cell fate specification The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti auditory hair cell fate specification biological_process owl:Class
GO:0018155 biolink:NamedThing peptide cross-linking via sn-(2S,6R)-lanthionine The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione). got7fsn_ti RESID:AA0111 biological_process owl:Class
GO:2000381 biolink:NamedThing negative regulation of mesoderm development Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development. got7fsn_ti vk 2011-02-15T03:10:02Z biological_process owl:Class
GO:0062120 biolink:NamedThing LinE complex assembly The aggregation, arrangement and bonding together of a set of components during meiotic prophase to form a LinE complex, the protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins. got7fsn_ti dph 2019-03-19T14:14:25Z biological_process owl:Class
GO:0046034 biolink:NamedThing ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. got7fsn_ti ATP metabolism biological_process owl:Class
GO:0097078 biolink:NamedThing FAL1-SGD1 complex A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits. got7fsn_ti pr 2011-06-17T09:59:10Z cellular_component owl:Class
GO:0060083 biolink:NamedThing smooth muscle contraction involved in micturition The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body. got7fsn_ti urinary bladder smooth muscle contraction involved in micturition|smooth muscle contraction involved in urination biological_process owl:Class
GO:0047221 biolink:NamedThing sn-glycerol-3-phosphate 2-alpha-galactosyltransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 2-(alpha-D-galactosyl)-sn-glycerol 3-phosphate + H(+) + UDP. got7fsn_ti floridoside-phosphate synthase activity|floridoside phosphate synthetase activity|UDP-galactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity|UDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity|UDP-galactose, sn-3-glycerol phosphate:1->2' galactosyltransferase activity|floridoside phosphate synthase activity|UDPgalactose:sn-glycerol-3-phosphate 2-alpha-D-galactosyltransferase activity|FPS MetaCyc:2.4.1.137-RXN|RHEA:14285|KEGG_REACTION:R00853|EC:2.4.1.137 molecular_function owl:Class
GO:0008809 biolink:NamedThing carnitine racemase activity Catalysis of the reaction: D-carnitine = L-carnitine. got7fsn_ti MetaCyc:CARNRACE-RXN molecular_function owl:Class
GO:0008754 biolink:NamedThing O antigen ligase activity Catalysis of the reaction: Lipid A-core + colanic acid = MLPS. got7fsn_ti MetaCyc:RXN0-5294 molecular_function owl:Class
GO:0018665 biolink:NamedThing 4-hydroxyphenylacetate 1-monooxygenase activity Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O. got7fsn_ti 4-hydroxyphenyl-acetate 1-hydroxylase activity|4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)|4-hydroxyphenylacetic 1-hydroxylase activity|4-hydroxyphenylacetate 1-hydroxylase activity|4-HPA 1-hydroxylase activity EC:1.14.13.18|MetaCyc:1.14.13.18-RXN|UM-BBD_reactionID:r0300 molecular_function owl:Class
GO:0021974 biolink:NamedThing trigeminothalamic tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face. got7fsn_ti biological_process owl:Class
GO:0070997 biolink:NamedThing neuron death The process of cell death in a neuron. got7fsn_ti neuronal cell death|neuron cell death This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. mah 2009-11-03T02:37:17Z biological_process owl:Class
GO:0044523 biolink:NamedThing envenomation resulting in damage of muscle extracellular matrix in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism. got7fsn_ti envenomation resulting in damage of muscle extracellular matrix causing muscle necrosis in other organism jl 2012-02-27T12:40:32Z biological_process owl:Class
GO:0015362 biolink:NamedThing high-affinity sodium:dicarboxylate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity sodium:dicarboxylate cotransporter activity|high affinity sodium:dicarboxylate symporter activity Reactome:R-HSA-433101 molecular_function owl:Class
GO:0050618 biolink:NamedThing phycoerythrobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin. got7fsn_ti (3Z)-phycoerythrobilin:ferredoxin oxidoreductase activity|PebB EC:1.3.7.3|MetaCyc:1.3.7.3-RXN|RHEA:22092 molecular_function owl:Class
GO:0042580 biolink:NamedThing mannosome A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction. got7fsn_ti cellular_component owl:Class
GO:0050113 biolink:NamedThing inositol oxygenase activity Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+). got7fsn_ti meso-inositol oxygenase activity|myo-inositol:oxygen oxidoreductase activity|myo-inositol oxygenase activity|MOO activity KEGG_REACTION:R01184|RHEA:23696|MetaCyc:MYO-INOSITOL-OXYGENASE-RXN|Reactome:R-HSA-5678327|EC:1.13.99.1 molecular_function owl:Class
GO:0048726 biolink:NamedThing labrum development The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0012509 biolink:NamedThing inter-Golgi transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances within the Golgi. got7fsn_ti inter-Golgi transport constitutive secretory pathway transport vesicle membrane cellular_component owl:Class
GO:0030663 biolink:NamedThing COPI-coated vesicle membrane The lipid bilayer surrounding a COPI-coated vesicle. got7fsn_ti COPI coated vesicle membrane cellular_component owl:Class
GO:0035866 biolink:NamedThing alphav-beta3 integrin-PKCalpha complex A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha. got7fsn_ti alphav-beta3 integrin-protein kinase C alpha complex|alphav-beta3 integrin-PKCa complex bf 2011-05-25T03:03:59Z cellular_component owl:Class
GO:0044558 biolink:NamedThing uterine smooth muscle relaxation A process in which the extent of smooth muscle contraction is reduced in the uterus. got7fsn_ti smooth muscle relaxation of the uterus jl 2012-04-05T02:57:11Z biological_process owl:Class
GO:0021611 biolink:NamedThing facial nerve formation The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. got7fsn_ti CN VII biosynthesis|CN VII formation biological_process owl:Class
GO:0046304 biolink:NamedThing 2-nitropropane catabolic process The chemical reactions and pathways resulting in the breakdown of 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. got7fsn_ti 2-nitropropane catabolism|2-nitropropane breakdown|2-nitropropane degradation biological_process owl:Class
GO:1904320 biolink:NamedThing positive regulation of smooth muscle contraction involved in micturition Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition. got7fsn_ti upregulation of urinary bladder smooth muscle contraction involved in micturition|up regulation of urinary bladder smooth muscle contraction involved in micturition|activation of urinary bladder smooth muscle contraction involved in micturition|up-regulation of smooth muscle contraction involved in urination|up-regulation of smooth muscle contraction involved in micturition|up-regulation of urinary bladder smooth muscle contraction involved in micturition|up regulation of smooth muscle contraction involved in urination|upregulation of smooth muscle contraction involved in micturition|activation of smooth muscle contraction involved in urination|activation of smooth muscle contraction involved in micturition|positive regulation of smooth muscle contraction involved in urination|positive regulation of urinary bladder smooth muscle contraction involved in micturition|up regulation of smooth muscle contraction involved in micturition|upregulation of smooth muscle contraction involved in urination sl 2015-06-10T18:46:23Z biological_process owl:Class
GO:0016072 biolink:NamedThing rRNA metabolic process The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes. got7fsn_ti rRNA metabolism biological_process owl:Class
GO:0005026 biolink:NamedThing transforming growth factor beta receptor activity, type II Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor. got7fsn_ti type II TGF-beta receptor activity|type II transforming growth factor beta receptor activity|transforming growth factor beta ligand binding to type II receptor|type II TGFbeta receptor activity Reactome:R-HSA-170843 molecular_function owl:Class
GO:0035345 biolink:NamedThing regulation of hypoxanthine transport Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti regulation of 6-hydroxypurine transport bf 2010-03-04T10:42:04Z biological_process owl:Class
GO:0032239 biolink:NamedThing regulation of nucleobase-containing compound transport Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport biological_process owl:Class
GO:0102570 biolink:NamedThing tyrosine:phenylpyruvate aminotransferase activity Catalysis of the reaction: keto-phenylpyruvate + L-tyrosine = L-phenylalanine + 3-(4-hydroxyphenyl)pyruvate. got7fsn_ti MetaCyc:RXN-15200 molecular_function owl:Class
GO:0017193 biolink:NamedThing N-terminal peptidyl-glycine acetylation The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine. got7fsn_ti RESID:AA0046 biological_process owl:Class
GO:0003136 biolink:NamedThing negative regulation of heart induction by canonical Wnt signaling pathway Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction. got7fsn_ti negative regulation of heart induction by canonical Wnt-activated signaling pathway|negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of heart induction by canonical Wnt receptor signalling pathway tb 2009-09-22T03:26:17Z biological_process owl:Class
GO:0009997 biolink:NamedThing negative regulation of cardioblast cell fate specification Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti suppression of cardioblast cell fate|downregulation of cardioblast cell fate specification|down-regulation of cardioblast cell fate specification|inhibition of cardioblast cell fate specification|down regulation of cardioblast cell fate specification GO:0042687 biological_process owl:Class
GO:0030786 biolink:NamedThing (RS)-norcoclaurine 6-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine. got7fsn_ti S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity RHEA:19941|MetaCyc:2.1.1.128-RXN|EC:2.1.1.128 molecular_function owl:Class
GO:0033687 biolink:NamedThing osteoblast proliferation The multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone. got7fsn_ti biological_process owl:Class
GO:0043653 biolink:NamedThing mitochondrial fragmentation involved in apoptotic process The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form. got7fsn_ti mitochondrial fragmentation involved in apoptosis|mitochondrial fission during apoptosis Although most of the processes described under 'apoptotic mitochondrial changes' take place during the signaling phase of apoptosis, 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed there. It is still controversial whether this process is involved in the signaling phase of apoptosis or not, so it was placed under the more generic 'apoptotic mitochondrial changes' parent rather than linked to the signaling or the execution phase until further research clarifies the matter. biological_process owl:Class
GO:0044343 biolink:NamedThing canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin. got7fsn_ti canonical Wnt receptor signaling pathway involved in regulation of pancreatic B cell proliferation|canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation|canonical Wnt receptor signalling pathway involved in regulation of pancreatic B cell proliferation|canonical Wnt receptor signaling pathway involved in pancreatic beta cell proliferation|canonical Wnt receptor signalling pathway involved in regulation of type B pancreatic cell proliferation|canonical Wnt-activated signaling pathway involved in regulation of type B pancreatic cell proliferation jl 2010-08-25T01:53:22Z biological_process owl:Class
GO:0061670 biolink:NamedThing evoked neurotransmitter secretion Neurotransmitter secretion that occurs in the presence of the action of a secretagogue or a presynaptic action potential. got7fsn_ti stimulus-dependant neurotransmitter secretion dph 2014-11-17T08:06:21Z biological_process owl:Class
GO:0102637 biolink:NamedThing 5-aminolevulinate-CoA ligase activity Catalysis of the reaction: 5-ammoniolevulinate + coenzyme A + ATP <=> 5-aminolevulinyl-CoA + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-15714 molecular_function owl:Class
GO:0002457 biolink:NamedThing T cell antigen processing and presentation The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti T lymphocyte antigen processing and presentation|T-cell antigen processing and presentation|T-lymphocyte antigen processing and presentation biological_process owl:Class
GO:0042952 biolink:NamedThing beta-ketoadipate pathway A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates. got7fsn_ti ortho-cleavage pathway biological_process owl:Class
GO:0009749 biolink:NamedThing response to glucose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. got7fsn_ti response to glucose stimulus biological_process owl:Class
GO:0043881 biolink:NamedThing mesaconyl-CoA hydratase activity Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA. got7fsn_ti mesaconyl-coenzyme A hydratase activity|beta-methylmalyl-CoA dehydratase activity|mch This function is part of an alternate glyoxylate cycle for acetate assimilation. molecular_function owl:Class
GO:0034935 biolink:NamedThing tetrachlorobenzene dioxygenase activity Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0957 molecular_function owl:Class
GO:0036391 biolink:NamedThing medial cortex septin ring A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. got7fsn_ti bf 2013-06-06T16:12:06Z cellular_component owl:Class
GO:0000950 biolink:NamedThing branched-chain amino acid catabolic process to alcohol via Ehrlich pathway The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols. got7fsn_ti branched chain family amino acid catabolic process to alcohol via Ehrlich pathway biological_process owl:Class
GO:0102089 biolink:NamedThing dehydroscoulerine synthase activity Catalysis of the reaction: (S)-scoulerine + O2 = dehydroscoulerine + hydrogen peroxide + H+. got7fsn_ti MetaCyc:RXN-10888 molecular_function owl:Class
GO:0060379 biolink:NamedThing cardiac muscle cell myoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life. got7fsn_ti cardiac myoblast differentiation|myocardial precursor cell differentiation biological_process owl:Class
GO:0097379 biolink:NamedThing dorsal spinal cord interneuron posterior axon guidance The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism. got7fsn_ti dorsal interneuron caudal axon projection pr 2012-10-01T10:22:38Z biological_process owl:Class
GO:0072414 biolink:NamedThing response to mitotic cell cycle checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling. got7fsn_ti mitotic cell cycle G1/S checkpoint effector process|response to signal involved in mitotic G2/M transition checkpoint|response to mitotic cell cycle G1/S checkpoint signaling|response to signal involved in mitotic cell cycle G1/S checkpoint|mitotic G2/M transition checkpoint effector process|response to signal involved in mitotic cell cycle checkpoint|mitotic cell cycle checkpoint effector process|response to mitotic G2/M transition checkpoint signal mah 2010-12-08T03:50:43Z GO:0072473|GO:0072455 biological_process owl:Class
GO:0005227 biolink:NamedThing calcium activated cation channel activity Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. got7fsn_ti intracellular calcium-activated potassium channel|polycystin molecular_function owl:Class
GO:0050460 biolink:NamedThing hydroxylamine reductase (NADH) activity Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+. got7fsn_ti N-hydroxy amine reductase activity|ammonium dehydrogenase activity|NADH-hydroxylamine reductase activity|NADH2:hydroxylamine oxidoreductase activity|NADH:hydroxylamine oxidoreductase activity|ammonium:NAD+ oxidoreductase activity|hydroxylamine reductase (NADH2) MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN|EC:1.7.1.10|RHEA:20581 molecular_function owl:Class
GO:1990112 biolink:NamedThing RQC complex A multiprotein complex that forms a stable complex with large ribosomal subunits (60S in eukaryotes and 50S in prokaryotes) containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins. got7fsn_ti ribosome quality control complex|ribosome-bound quality control complex rb 2013-05-31T21:42:43Z cellular_component owl:Class
GO:0019108 biolink:NamedThing aryl-aldehyde dehydrogenase (NAD) activity Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+. got7fsn_ti aryl-aldehyde:NAD+ oxidoreductase activity UM-BBD_reactionID:r0394|MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN|RHEA:11804|EC:1.2.1.29 molecular_function owl:Class
GO:0031121 biolink:NamedThing equatorial microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell. got7fsn_ti equatorial microtubule organisation|equatorial microtubule organization and biogenesis biological_process owl:Class
GO:0019466 biolink:NamedThing ornithine catabolic process via proline The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline. got7fsn_ti ornithine breakdown via proline|ornithine degradation via proline MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY biological_process owl:Class
GO:0051519 biolink:NamedThing activation of bipolar cell growth Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell. got7fsn_ti biological_process owl:Class
GO:0051518 biolink:NamedThing positive regulation of bipolar cell growth Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. got7fsn_ti upregulation of bipolar cell growth|up-regulation of bipolar cell growth|up regulation of bipolar cell growth|stimulation of bipolar cell growth biological_process owl:Class
GO:0018343 biolink:NamedThing protein farnesylation The covalent attachment of a farnesyl group to a protein. got7fsn_ti C-terminal protein farnesylation|protein amino acid farnesylation GO:0018347 biological_process owl:Class
GO:0019732 biolink:NamedThing antifungal humoral response An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster. got7fsn_ti GO:0019734|GO:0006966 biological_process owl:Class
GO:0051785 biolink:NamedThing positive regulation of nuclear division Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information. got7fsn_ti activation of nuclear division|up regulation of nuclear division|stimulation of nuclear division|up-regulation of nuclear division|upregulation of nuclear division biological_process owl:Class
GO:0106348 biolink:NamedThing U2 snRNA adenosine m6 methytransferase activity Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+. got7fsn_ti hjd 2020-12-18T15:12:57Z molecular_function owl:Class
GO:0086017 biolink:NamedThing Purkinje myocyte action potential An action potential that occurs in a Purkinje myocyte. got7fsn_ti tb 2011-11-10T08:58:56Z biological_process owl:Class
GO:0071351 biolink:NamedThing cellular response to interleukin-18 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. got7fsn_ti cellular response to IL-18 mah 2009-12-11T02:50:03Z biological_process owl:Class
GO:0070673 biolink:NamedThing response to interleukin-18 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-18 stimulus. got7fsn_ti response to IL-18 mah 2009-05-29T10:03:52Z biological_process owl:Class
GO:0140700 biolink:NamedThing 3',2'-cyclic GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(2'-5') (cyclic 3',2' GAMP). got7fsn_ti 3',2' cyclic-GMP-AMP synthase activity|3',2'-cyclic GAMP synthase activity https://github.com/geneontology/go-ontology/issues/21980 pg 2021-08-27T05:11:54Z molecular_function owl:Class
GO:0140699 biolink:NamedThing cyclic GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP. got7fsn_ti cyclic-GMP-AMP synthase activity https://github.com/geneontology/go-ontology/issues/21980 Note that this term should not be used for direct annotation. It should be possible to annotate to a more specific child term that descibes the position of the phosphate group on the cGAMP molecule. pg 2021-08-27T05:05:37Z molecular_function owl:Class
GO:0043831 biolink:NamedThing thiosulfate dehydrogenase (quinone) activity Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate. got7fsn_ti thiosulphate:quinone oxidoreductase activity|DoxA|thiosulfate:6-decylubiquinone oxidoreductase activity|thiosulphate dehydrogenase (quinone) activity|thiosulfate:quinone oxidoreductase activity|TQO|thiosulfate oxidoreductase, tetrathionate-forming activity|DoxD MetaCyc:1.8.5.2-RXN|KEGG_REACTION:R07177|RHEA:10936|EC:1.8.5.2 molecular_function owl:Class
GO:0034360 biolink:NamedThing chylomicron remnant A lipoprotein particle that is derived from a mature chylomicron particle by the removal of triglycerides from the chylomicron core by lipoprotein lipase and the subsequent loss of surface components. It characteristically contains apolipoprotein E (APOE) and is cleared from the blood by the liver. got7fsn_ti cellular_component owl:Class
GO:0102573 biolink:NamedThing aminodeoxyfutalosine synthase activity Catalysis of the reaction: 3-[(1-carboxylatovinyl)oxy]benzoate(2-) + S-adenosyl-L-methionine + H2O <=> aminodeoxyfutalosinate + L-methionine + hydrogencarbonate + H+. got7fsn_ti RHEA:33075|EC:2.5.1.120|MetaCyc:RXN-15264 molecular_function owl:Class
GO:0008158 biolink:NamedThing hedgehog receptor activity Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. got7fsn_ti patched activity molecular_function owl:Class
GO:0052626 biolink:NamedThing benzoate amino acid synthetase activity Catalysis of the reaction: benzoate + ATP + amino acid = benzoyl amino acid conjugate + AMP + diphosphate. got7fsn_ti benzoyl amino acid synthetase activity molecular_function owl:Class
GO:0019479 biolink:NamedThing L-alanine oxidation to D-lactate and ammonia The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia. got7fsn_ti MetaCyc:ALACAT2-PWY biological_process owl:Class
GO:0042853 biolink:NamedThing L-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. got7fsn_ti L-alanine breakdown|L-alanine degradation|L-alanine catabolism biological_process owl:Class
GO:0005262 biolink:NamedThing calcium channel activity Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti Reactome:R-HSA-3295579|Reactome:R-HSA-8949145|Reactome:R-HSA-139855|Reactome:R-HSA-210420|Reactome:R-HSA-139854|Reactome:R-HSA-8949178 molecular_function owl:Class
GO:0009946 biolink:NamedThing proximal/distal axis specification The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end). got7fsn_ti proximal/distal axis determination|proximodistal axis specification biological_process owl:Class
GO:0021686 biolink:NamedThing cerebellar granular layer maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer. got7fsn_ti biological_process owl:Class
GO:0015297 biolink:NamedThing antiporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). got7fsn_ti solute:solute antiporter activity|exchange transporter activity|exchanger|porter|countertransporter activity|antiport|ion antiporter activity|solute:solute exchange GO:0015300|GO:0099516 Reactome:R-HSA-2731002|Reactome:R-HSA-2730959|Reactome:R-HSA-2730692 molecular_function owl:Class
GO:0033656 biolink:NamedThing modification by symbiont of host chloroplast The process in which an organism effects a change in the structure or function of host cell chloroplasts. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0090511 biolink:NamedThing periclinal cell division A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file. got7fsn_ti tb 2012-11-21T11:52:40Z biological_process owl:Class
GO:0099639 biolink:NamedThing neurotransmitter receptor transport, endosome to plasma membrane The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles. got7fsn_ti biological_process owl:Class
GO:0050198 biolink:NamedThing pinosylvin synthase activity Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO(2) + 4 CoA + pinosylvin. got7fsn_ti malonyl-CoA:cinnamoyl-CoA malonyltransferase (cyclizing)|pine stilbene synthase activity|stilbene synthase activity KEGG_REACTION:R02505|MetaCyc:PINOSYLVIN-SYNTHASE-RXN|EC:2.3.1.146|RHEA:12552 molecular_function owl:Class
GO:0004154 biolink:NamedThing dihydropterin oxidase activity Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide. got7fsn_ti molecular_function owl:Class
GO:0035860 biolink:NamedThing glial cell-derived neurotrophic factor receptor signaling pathway The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands. got7fsn_ti glial cell-derived neurotrophic factor receptor signalling pathway|glial cell derived neurotrophic factor receptor signaling pathway|glial cell line-derived neurotrophic factor receptor signalling pathway|GDNF receptor signaling pathway bf 2011-05-17T11:01:33Z biological_process owl:Class
GO:0004824 biolink:NamedThing lysine-tRNA ligase activity Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). got7fsn_ti lysine translase activity|L-lysine:tRNALys ligase (AMP-forming)|L-lysine-transfer RNA ligase activity|lysyl-transfer ribonucleate synthetase activity|lysine-tRNA synthetase activity|lysyl-tRNA synthetase activity|lysyl-transfer RNA synthetase activity Reactome:R-HSA-380008|Reactome:R-HSA-380233|EC:6.1.1.6|RHEA:20792|MetaCyc:LYSINE--TRNA-LIGASE-RXN molecular_function owl:Class
GO:0090516 biolink:NamedThing L-serine transmembrane import into vacuole The directed movement of L-serine into the vacuole across the vacuolar membrane. got7fsn_ti tb 2012-12-14T11:25:52Z biological_process owl:Class
GO:0034491 biolink:NamedThing neutral amino acid transmembrane import into vacuole The directed movement of neutral amino acids into the vacuole across the vacuolar membrane. got7fsn_ti biological_process owl:Class
GO:0018013 biolink:NamedThing N-terminal peptidyl-glycine methylation The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine. got7fsn_ti RESID:AA0063 biological_process owl:Class
GO:0097181 biolink:NamedThing protein C inhibitor-coagulation factor V complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V. got7fsn_ti protein C inhibitor-F5 complex|plasma serine protease inhibitor-coagulation factor V complex|serpin A5-coagulation factor V complex|PCI-coagulation factor V complex|SERPINA5-coagulation factor V complex pr 2011-10-16T08:57:03Z cellular_component owl:Class
GO:0003276 biolink:NamedThing apoptotic process involved in heart valve morphogenesis Any apoptotic process that contributes to the shaping of a heart valve. got7fsn_ti apoptosis involved in heart valve morphogenesis dph 2009-10-20T09:34:29Z biological_process owl:Class
GO:0003278 biolink:NamedThing apoptotic process involved in heart morphogenesis Any apoptotic process that contributes to the shaping of the heart. got7fsn_ti apoptosis involved in heart morphogenesis dph 2009-10-20T09:40:22Z biological_process owl:Class
GO:0018928 biolink:NamedThing methyl ethyl ketone metabolic process The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints. got7fsn_ti MEK metabolism|methyl ethyl ketone metabolism|MEK metabolic process|2-butanone metabolic process|2-butanone metabolism UM-BBD_pathwayID:mek biological_process owl:Class
GO:0004441 biolink:NamedThing inositol-1,4-bisphosphate 1-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate. got7fsn_ti 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity|inositol-polyphosphate 1-phosphatase activity|inositol polyphosphate 1-phosphatase activity RHEA:15553|EC:3.1.3.57|Reactome:R-HSA-1855208|MetaCyc:3.1.3.57-RXN molecular_function owl:Class
GO:0002332 biolink:NamedThing transitional stage B cell differentiation The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent. got7fsn_ti transitional stage B lymphocyte differentiation|transitional stage B-cell differentiation|transitional stage B-lymphocyte differentiation|transitional stage B cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0002327 biolink:NamedThing immature B cell differentiation The process in which a precursor cell type acquires the specialized features of an immature B cell. got7fsn_ti immature B-cell differentiation|immature B lymphocyte differentiation|immature B-lymphocyte differentiation|immature B cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0048525 biolink:NamedThing negative regulation of viral process Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process in which a virus is a participant. got7fsn_ti negative regulation of viral reproduction|down regulation of viral life cycle|downregulation of viral life cycle|negative regulation of viral life cycle|inhibition of viral life cycle|down-regulation of viral life cycle biological_process owl:Class
GO:0030877 biolink:NamedThing beta-catenin destruction complex A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. got7fsn_ti 23S APC complex|BDC|beta-catenin degradation complex|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. GO:0034747|GO:0034742 cellular_component owl:Class
GO:0000833 biolink:NamedThing inositol heptakisphosphate 4-kinase activity Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate. got7fsn_ti diphosphoinositol-pentakisphosphate 4-kinase activity|IP7 4-kinase activity molecular_function owl:Class
GO:0008874 biolink:NamedThing gluconate 5-dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+. got7fsn_ti 5-keto-D-gluconate reductase|5-ketogluconate reductase activity|5-keto-D-gluconate 5-reductase activity|5-ketogluconate 5-reductase activity|D-gluconate:NAD(P)+ 5-oxidoreductase MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN|EC:1.1.1.69 molecular_function owl:Class
GO:0008875 biolink:NamedThing gluconate dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+. got7fsn_ti molecular_function owl:Class
GO:0018277 biolink:NamedThing protein deamination The removal of an amino group from a protein amino acid. got7fsn_ti protein amino acid deamination biological_process owl:Class
GO:0018026 biolink:NamedThing peptidyl-lysine monomethylation The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine. got7fsn_ti RESID:AA0076 biological_process owl:Class
GO:0061545 biolink:NamedThing tyramine secretion The regulated release of a tyramine by a cell. got7fsn_ti dph 2013-06-25T09:14:07Z biological_process owl:Class
GO:0007639 biolink:NamedThing homeostasis of number of meristem cells Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem. got7fsn_ti biological_process owl:Class
GO:0072271 biolink:NamedThing metanephric short descending thin limb development The process whose specific outcome is the progression of the metanephric short descending thin limb over time, from its formation to the mature structure. The metanephric short descending thin limb is the descending thin limb of a short nephron in the metanephros that has a squamous epithelial morphology. got7fsn_ti mah 2010-03-30T03:16:25Z biological_process owl:Class
GO:0015400 biolink:NamedThing low-affinity secondary active ammonium transmembrane transporter activity Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low affinity ammonium transmembrane transporter activity|low affinity secondary active ammonium transmembrane transporter activity molecular_function owl:Class
GO:0036183 biolink:NamedThing asperthecin catabolic process The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. got7fsn_ti asperthecin degradation|asperthecin catabolism|asperthecin breakdown bf 2012-04-16T11:36:38Z biological_process owl:Class
GO:0030557 biolink:NamedThing tRNA modification guide activity Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0044635 biolink:NamedThing positive regulation of complement activation, alternative pathway in other organism Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism. got7fsn_ti jl 2012-07-05T04:36:11Z biological_process owl:Class
GO:0045958 biolink:NamedThing positive regulation of complement activation, alternative pathway Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway. got7fsn_ti positive regulation of complement cascade, alternative pathway|up-regulation of complement activation, alternative pathway|upregulation of complement activation, alternative pathway|up regulation of complement activation, alternative pathway|activation of complement activation, alternative pathway|stimulation of complement activation, alternative pathway biological_process owl:Class
GO:0050359 biolink:NamedThing tropomyosin kinase activity Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin. got7fsn_ti STK|ATP:tropomyosin O-phosphotransferase activity|tropomyosin kinase (phosphorylating) activity EC:2.7.11.28|MetaCyc:TROPOMYOSIN-KINASE-RXN molecular_function owl:Class
GO:0018653 biolink:NamedThing 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline. got7fsn_ti UM-BBD_reactionID:r0046|EC:1.14.13.- molecular_function owl:Class
GO:0047738 biolink:NamedThing cellobiose phosphorylase activity Catalysis of the reaction: cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose. got7fsn_ti cellobiose:phosphate alpha-D-glucosyltransferase activity MetaCyc:CELLOBIOSE-PHOSPHORYLASE-RXN|EC:2.4.1.20|RHEA:19493 molecular_function owl:Class
GO:0120063 biolink:NamedThing stomach smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs throughout the length of the stomach. got7fsn_ti krc 2017-06-13T22:20:16Z biological_process owl:Class
GO:0035901 biolink:NamedThing cellular response to isolation stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species. got7fsn_ti cellular response to social isolation bf 2011-06-22T09:43:34Z biological_process owl:Class
GO:0035900 biolink:NamedThing response to isolation stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species. got7fsn_ti response to social isolation bf 2011-06-22T09:39:57Z biological_process owl:Class
GO:0050296 biolink:NamedThing stipitatonate decarboxylase activity Catalysis of the reaction: H(2)O + stipitatonate = CO(2) + H(+) + stipitatate. got7fsn_ti stipitatonate carboxy-lyase (decyclizing, stipitatate-forming)|stipitatonate carboxy-lyase (decyclizing) MetaCyc:STIPITATONATE-DECARBOXYLASE-RXN|RHEA:13885|EC:4.1.1.60|KEGG_REACTION:R03739 molecular_function owl:Class
GO:0018148 biolink:NamedThing RNA-protein covalent cross-linking via peptidyl-tyrosine The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine. got7fsn_ti RESID:AA0249 biological_process owl:Class
GO:1990638 biolink:NamedThing response to granulocyte colony-stimulating factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus. got7fsn_ti response to G-CSF sl 2015-02-11T00:02:33Z biological_process owl:Class
GO:0048046 biolink:NamedThing apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. got7fsn_ti Wikipedia:Apoplast cellular_component owl:Class
GO:0050100 biolink:NamedThing methylitaconate delta-isomerase activity Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate. got7fsn_ti methylitaconate isomerase activity|methylitaconate delta2-delta3-isomerase activity|methylitaconate D-isomerase activity MetaCyc:METHYLITACONATE-DELTA-ISOMERASE-RXN|KEGG_REACTION:R03070|RHEA:23480|EC:5.3.3.6 molecular_function owl:Class
GO:0004585 biolink:NamedThing ornithine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. got7fsn_ti L-ornithine transcarbamylase activity|L-ornithine carbamyltransferase activity|L-ornithine carbamoyltransferase activity|ornithine carbamyltransferase activity|carbamoyl-phosphate:L-ornithine carbamoyltransferase activity|carbamylphosphate-ornithine transcarbamylase activity|citrulline phosphorylase activity|ornithine transcarbamylase activity|OTC activity|OTCase activity MetaCyc:RXN-13482|Reactome:R-HSA-70560|EC:2.1.3.3|RHEA:19513|MetaCyc:ORNCARBAMTRANSFER-RXN molecular_function owl:Class
GO:0004605 biolink:NamedThing phosphatidate cytidylyltransferase activity Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol. got7fsn_ti CDP-diacylglycerol synthase activity|DAG synthetase activity|CTP:phosphatidate cytidylyltransferase activity|CDP-diglyceride synthetase activity|phosphatidic acid cytidylyltransferase activity|CDP-diglyceride diphosphorylase activity|CDP-diglyceride pyrophosphorylase activity|CTP-diacylglycerol synthetase activity|CDP-diacylglyceride synthetase activity|CDP-DG|phosphatidate cytidyltransferase activity|CDP diglyceride pyrophosphorylase activity|CTP:1,2-diacylglycerophosphate-cytidyl transferase activity|cytidine diphosphoglyceride pyrophosphorylase activity|CDP-diglyceride synthase activity Reactome:R-HSA-1483121|RHEA:16229|EC:2.7.7.41|MetaCyc:CDPDIGLYSYN-RXN|Reactome:R-HSA-1483165 molecular_function owl:Class
GO:0019411 biolink:NamedThing aerobic respiration, using ferrous ions as electron donor The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide. got7fsn_ti biological_process owl:Class
GO:0047618 biolink:NamedThing acylagmatine amidase activity Catalysis of the reaction: N(4)-benzoylagmatine + H(2)O = agmatine + benzoate. got7fsn_ti benzoylagmatine amidohydrolase activity|acylagmatine amidohydrolase activity|acylagmatine deacylase activity KEGG_REACTION:R01425|MetaCyc:ACYLAGMATINE-AMIDASE-RXN|EC:3.5.1.40|RHEA:15065 molecular_function owl:Class
GO:0004830 biolink:NamedThing tryptophan-tRNA ligase activity Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). got7fsn_ti TrpRS activity|tryptophanyl-tRNA synthase activity|tryptophanyl-transfer ribonucleic synthetase activity|tryptophanyl ribonucleic synthetase activity|tryptophanyl-transfer ribonucleate synthetase activity|tryptophanyl-tRNA synthetase activity|L-tryptophan:tRNATrp ligase (AMP-forming)|L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity|tryptophanyl-transfer RNA synthetase activity|tryptophanyl-transfer ribonucleic acid synthetase activity|L-tryptophan-tRNATrp ligase (AMP-forming)|tryptophan translase activity RHEA:24080|Reactome:R-HSA-380222|Reactome:R-HSA-379977|EC:6.1.1.2|MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN molecular_function owl:Class
GO:0021538 biolink:NamedThing epithalamus development The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle. got7fsn_ti biological_process owl:Class
GO:0106274 biolink:NamedThing NAD+-protein-arginine ADP-ribosyltransferase activity Catalysis of the reaction: NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine. got7fsn_ti hjd 2020-07-02T01:37:02Z EC:2.4.2.31|RHEA:19149 molecular_function owl:Class
GO:0102850 biolink:NamedThing 1-18:1-2-16:0-phosphatidylglycerol omega-6 desaturase activity Catalysis of the reaction: 1-[(9Z)-octadec-9-enoyl]-2-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)(1-) + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.23|MetaCyc:RXN-8316|RHEA:46376 molecular_function owl:Class
GO:0034919 biolink:NamedThing butyryl-CoA 2-C-propionyltransferase activity Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA. got7fsn_ti UM-BBD_reactionID:r0931 molecular_function owl:Class
GO:0004801 biolink:NamedThing transaldolase activity Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. got7fsn_ti dihydroxyacetonetransferase activity|glycerone transferase activity|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity|dihydroxyacetone transferase activity https://github.com/geneontology/go-ontology/issues/20486 EC:2.2.1.2|Reactome:R-HSA-71334|MetaCyc:TRANSALDOL-RXN|Reactome:R-HSA-5659989|Reactome:R-HSA-5659998|Reactome:R-HSA-163764|RHEA:17053 molecular_function owl:Class
GO:0102735 biolink:NamedThing trihydroxybenzophenone synthase activity Catalysis of the reaction: benzoyl-CoA + 3 malonyl-CoA + 3 H+ = 2,4,6-trihydroxybenzophenone + 4 coenzyme A + 3 carbon dioxide. got7fsn_ti EC:2.3.1.220|RHEA:35143|MetaCyc:RXN-7481 molecular_function owl:Class
GO:0098868 biolink:NamedThing bone growth The increase in size or mass of a bone that contributes to the shaping of that bone. got7fsn_ti biological_process owl:Class
GO:0030200 biolink:NamedThing heparan sulfate proteoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups. got7fsn_ti heparan sulphate proteoglycan catabolic process|heparan sulfate proteoglycan catabolism|heparan sulfate proteoglycan degradation|heparan sulphate proteoglycan catabolism|heparin proteoglycan catabolic process|heparan sulfate proteoglycan breakdown biological_process owl:Class
GO:0030167 biolink:NamedThing proteoglycan catabolic process The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. got7fsn_ti proteoglycan degradation|proteoglycan catabolism|proteoglycan breakdown biological_process owl:Class
GO:0106261 biolink:NamedThing tRNA uridine(34) acetyltransferase activity Catalysis of the reaction: acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine(34) in tRNA = 5'-deoxyadenosine + carboxymethyluridine(34) in tRNA + CoA + 2 H(+) + L-methionine. got7fsn_ti hjd 2020-05-08T15:21:51Z RHEA:61020 molecular_function owl:Class
GO:0010659 biolink:NamedThing cardiac muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. got7fsn_ti cardiac muscle cell apoptosis biological_process owl:Class
GO:0010658 biolink:NamedThing striated muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations. got7fsn_ti striated muscle cell apoptosis biological_process owl:Class
GO:0031475 biolink:NamedThing myosin V complex A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region. got7fsn_ti cellular_component owl:Class
GO:0097570 biolink:NamedThing cyst wall The specialized envelope lying outside the cell membrane of a cyst. A cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. In protists such as protozoan parasites alternating cystic- and non-cystic stages, the cyst wall is usually composed of carbohydrates and proteins. got7fsn_ti pr 2014-02-18T10:25:53Z cellular_component owl:Class
GO:0000450 biolink:NamedThing cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species. got7fsn_ti biological_process owl:Class
GO:0019657 biolink:NamedThing glycolytic fermentation to propionate Glycolytic fermentation resulting in the catabolism of glucose to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate. got7fsn_ti succinate-propionate fermentation MetaCyc:P108-PWY biological_process owl:Class
GO:0035040 biolink:NamedThing sperm nuclear envelope removal Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus. got7fsn_ti biological_process owl:Class
GO:0002562 biolink:NamedThing somatic diversification of immune receptors via germline recombination within a single locus The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. got7fsn_ti biological_process owl:Class
GO:1900541 biolink:NamedThing fumonisin biosynthetic process The chemical reactions and pathways resulting in the formation of fumonisin. got7fsn_ti fumonisin synthesis|fumonisin formation|fumonisin anabolism|fumonisin biosynthesis tb 2012-05-11T12:54:37Z biological_process owl:Class
GO:0106035 biolink:NamedThing protein maturation by [4Fe-4S] cluster transfer The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. got7fsn_ti hjd 2017-07-07T17:26:10Z biological_process owl:Class
GO:0097428 biolink:NamedThing protein maturation by iron-sulfur cluster transfer The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. got7fsn_ti pr 2012-11-15T09:59:06Z biological_process owl:Class
GO:0052808 biolink:NamedThing reduced coenzyme F420:NADP+ oxidoreductase activity Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. got7fsn_ti F420H2:NADP oxidoreductase activity|F420H2:NADP+ oxidoreductase activity|coenzyme F420-dependent NADP oxidoreductase activity|coenzyme F420-dependent NADP reductase activity|NADP+:F420 oxidoreductase activity ai 2011-09-22T04:08:13Z EC:1.5.1.40 molecular_function owl:Class
GO:0043983 biolink:NamedThing histone H4-K12 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone. got7fsn_ti histone H4 acetylation at K12 biological_process owl:Class
GO:0033717 biolink:NamedThing gluconate 2-dehydrogenase (acceptor) activity Catalysis of the reaction: D-gluconate + acceptor = 2-dehydro-D-gluconate + reduced acceptor. got7fsn_ti D-gluconate:acceptor 2-oxidoreductase activity|D-gluconate:(acceptor) 2-oxidoreductase activity|gluconic dehydrogenase activity|D-gluconate dehydrogenase, 2-keto-D-gluconate-yielding activity|gluconic acid dehydrogenase activity|D-gluconate dehydrogenase activity|2-ketogluconate reductase activity|gluconate oxidase activity EC:1.1.99.3|RHEA:12769|MetaCyc:GLUCONATE-2-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0004594 biolink:NamedThing pantothenate kinase activity Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. got7fsn_ti ATP:pantothenate 4'-phosphotransferase activity|D-pantothenate kinase activity|ATP:(R)-pantothenate 4'-phosphotransferase activity|pantothenate kinase (phosphorylating) activity|pantothenic acid kinase activity MetaCyc:PANTOTHENATE-KIN-RXN|EC:2.7.1.33|Reactome:R-HSA-196857|RHEA:16373|Reactome:R-HSA-199203 molecular_function owl:Class
GO:0030945 biolink:NamedThing protein tyrosine phosphatase activity, via thiol-phosphate intermediate The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate. got7fsn_ti molecular_function owl:Class
GO:0043899 biolink:NamedThing phosphoserine:homoserine phosphotransferase activity Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine. got7fsn_ti thrH molecular_function owl:Class
GO:1900593 biolink:NamedThing violaceol II biosynthetic process The chemical reactions and pathways resulting in the formation of violaceol II. got7fsn_ti violaceol II synthesis|violaceol II formation|violaceol II anabolism|violaceol II biosynthesis di 2012-05-15T06:51:51Z biological_process owl:Class
GO:0001802 biolink:NamedThing type III hypersensitivity An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue. got7fsn_ti Note that the Arthus reaction is an example of type III hypersensitivity. Wikipedia:Type_III_hypersensitivity biological_process owl:Class
GO:0016064 biolink:NamedThing immunoglobulin mediated immune response An immune response mediated by immunoglobulins, whether cell-bound or in solution. got7fsn_ti antibody-mediated immune response biological_process owl:Class
GO:0061100 biolink:NamedThing lung neuroendocrine cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium. got7fsn_ti dph 2010-04-27T03:28:46Z biological_process owl:Class
GO:0018604 biolink:NamedThing 4-aminobenzoate 3,4-dioxygenase (deaminating) activity Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate. got7fsn_ti UM-BBD_reactionID:r0566|EC:1.14.12.- molecular_function owl:Class
GO:0018497 biolink:NamedThing 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS. got7fsn_ti DDMS dehydrogenase activity UM-BBD_reactionID:r0514 molecular_function owl:Class
GO:0018475 biolink:NamedThing trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid. got7fsn_ti UM-BBD_reactionID:r0745 molecular_function owl:Class
GO:0005132 biolink:NamedThing type I interferon receptor binding Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). got7fsn_ti interferon-alpha/beta receptor ligand|IFNAR1 binding|interferon-alpha/beta|IFNAR binding|IFNAR2 binding|interferon-alpha/beta receptor binding molecular_function owl:Class
GO:0050510 biolink:NamedThing N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. got7fsn_ti N-acetylgalactosaminyl-proteoglycan 3-b-glucuronosyltransferase activity|chondroitin glucuronyltransferase II activity|alpha-D-glucuronate:N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 3-beta-glucuronosyltransferase activity MetaCyc:2.4.1.226-RXN|EC:2.4.1.226|Reactome:R-HSA-9632034|Reactome:R-HSA-1971491|Reactome:R-HSA-3595178 molecular_function owl:Class
GO:0033544 biolink:NamedThing fatty acid beta-oxidation, unsaturated, even number, epimerase pathway A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti biological_process owl:Class
GO:0102986 biolink:NamedThing trehalose synthase activity Catalysis of the reaction: an NDP-alpha-D-glucose + D-glucopyranose <=> alpha,alpha-trehalose + H+ + a nucleoside diphosphate. got7fsn_ti MetaCyc:RXN-9603|EC:2.4.1.245|RHEA:47416 molecular_function owl:Class
GO:0019598 biolink:NamedThing (R)-mandelate catabolic process to catechol The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol. got7fsn_ti (R)-mandelate breakdown to catechol|(R)-mandelate degradation to catechol biological_process owl:Class
GO:0050186 biolink:NamedThing phosphoadenylylsulfatase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate. got7fsn_ti 3-phosphoadenosine 5-phosphosulfate sulfatase activity|3-phosphoadenylyl sulfatase activity|3'-phosphoadenylylsulfate sulfohydrolase activity|PAPS sulfatase activity|phosphoadenylylsulphatase activity RHEA:11232|EC:3.6.2.2|MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN molecular_function owl:Class
GO:0016819 biolink:NamedThing hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-. got7fsn_ti hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides EC:3.6.2.- molecular_function owl:Class
GO:0060514 biolink:NamedThing prostate induction The close range interaction of the urogenital sinus mesenchyme and the urogenital sinus epithelium that causes the cells of the urogenital sinus epithelium to change their fates and specify the development of the prostate gland. got7fsn_ti biological_process owl:Class
GO:0060685 biolink:NamedThing regulation of prostatic bud formation Any process that modulates the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth. got7fsn_ti dph 2009-06-05T12:29:26Z biological_process owl:Class
GO:0080151 biolink:NamedThing positive regulation of salicylic acid mediated signaling pathway Any process that activates or increases the frequency, rate or extent of salicylic acid mediated signal transduction. got7fsn_ti positive regulation of salicylic acid mediated signalling pathway dhl 2010-05-20T03:10:46Z biological_process owl:Class
GO:0007531 biolink:NamedThing mating type determination Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms. got7fsn_ti biological_process owl:Class
GO:0102758 biolink:NamedThing very-long-chain enoyl-CoA reductase activity Catalysis of the reaction: NADP(3-) + a very-long-chain 2,3,4-saturated fatty acyl CoA <=> NADPH(4-) + H+ + a very-long-chain trans-2,3-dehydroacyl-CoA. got7fsn_ti EC:1.3.1.93|MetaCyc:RXN-7711|RHEA:14473 molecular_function owl:Class
GO:0048279 biolink:NamedThing vesicle fusion with endoplasmic reticulum The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the endoplasmic reticulum. got7fsn_ti vesicle fusion with ER biological_process owl:Class
GO:0039592 biolink:NamedThing suppression by virus of G2/M transition of host mitotic cell cycle Any viral process that decreases the rate or extent of progression from G2 phase to M phase of the host mitotic cell cycle. got7fsn_ti host G2/M cell cycle arrest by virus bf 2012-06-25T02:07:18Z VZ:876 biological_process owl:Class
GO:0060153 biolink:NamedThing modulation by virus of host cell cycle Any viral process that modulates the rate or extent of progression through the cell cycle. got7fsn_ti viral process regulating host cell cycle|regulation by virus of host cell cycle|modulation of host cell cycle by virus|regulation of host cell cycle by virus VZ:1636 biological_process owl:Class
GO:0060954 biolink:NamedThing neural crest-derived cardiac glial cell development The process aimed at the progression of a neural crest-derived cardiac glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti dph 2009-09-29T03:14:15Z biological_process owl:Class
GO:0032617 biolink:NamedThing interleukin-14 production The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-14 biosynthetic process|interleukin-14 secretion|IL-14 production GO:0072612|GO:0042232 biological_process owl:Class
GO:0061430 biolink:NamedThing bone trabecula morphogenesis The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod. got7fsn_ti dph 2012-02-07T10:15:36Z biological_process owl:Class
GO:0150061 biolink:NamedThing amylin receptor 3 signaling pathway A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 3 (AMY3), a G protein-coupled receptor complex, on the surface of the target cell. The AMY3 signaling pathway can also be initiated by the amyloid-beta complex. AMY3 signaling results in increased import of calcium ions into the cytosol across plasma membrane, increased phosphorylation of ERK1/2, Act, and a PKA regulatory subunit II, as well as increased expression of cFos. got7fsn_ti AMY3 signaling pathway bc 2018-06-21T11:02:09Z biological_process owl:Class
GO:0000917 biolink:NamedThing division septum assembly The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. got7fsn_ti division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle|septin assembly and septum formation involved in mitotic cell cycle|formation of division septum involved in mitotic cell cycle|septation|septin assembly and septum biosynthesis involved in mitotic cell cycle|division septum formation involved in mitotic cell cycle|septin assembly and septum biosynthesis|formation of division septum|septin assembly and septum formation|mitotic division septum assembly|division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle|division septum formation involved in cell cycle cytokinesis|division septum formation|division septum assembly involved in cell cycle cytokinesis GO:0071937|GO:1902411 biological_process owl:Class
GO:0030563 biolink:NamedThing snRNA 2'-O-ribose methylation guide activity Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule. got7fsn_ti Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. molecular_function owl:Class
GO:0019341 biolink:NamedThing dibenzo-p-dioxin catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. got7fsn_ti dibenzo-p-dioxin degradation|dibenzo-p-dioxin breakdown|dibenzo-p-dioxin catabolism MetaCyc:P661-PWY biological_process owl:Class
GO:0036297 biolink:NamedThing interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. got7fsn_ti ICL repair bf 2012-08-07T11:05:19Z biological_process owl:Class
GO:0048291 biolink:NamedThing isotype switching to IgG isotypes The switching of activated B cells from IgM biosynthesis to biosynthesis of an IgG isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgG constant region gene segments in the immunoglobulin heavy chain locus. got7fsn_ti class switching to IgG isotypes|isotype switch recombination to IgG isotypes biological_process owl:Class
GO:0004141 biolink:NamedThing dethiobiotin synthase activity Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate. got7fsn_ti 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)|desthiobiotin synthase activity|DTB synthetase activity KEGG_REACTION:R03182|EC:6.3.3.3|MetaCyc:DETHIOBIOTIN-SYN-RXN|RHEA:15805 molecular_function owl:Class
GO:0035572 biolink:NamedThing N-terminal peptidyl-serine dimethylation The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine. got7fsn_ti bf 2010-08-06T02:00:17Z biological_process owl:Class
GO:0003068 biolink:NamedThing regulation of systemic arterial blood pressure by acetylcholine The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter. got7fsn_ti blood pressure regulation by acetylcholine biological_process owl:Class
GO:0097420 biolink:NamedThing skein-like inclusion Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin. got7fsn_ti pr 2012-11-06T20:58:35Z NIF_Subcellular:nlx_subcell_20090103 cellular_component owl:Class
GO:0110093 biolink:NamedThing nucleus lagging edge The area of a motile nucleus furthest from the direction of movement. got7fsn_ti kmv 2018-02-14T22:56:12Z cellular_component owl:Class
GO:1990341 biolink:NamedThing thrombospondin complex A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour. got7fsn_ti bhm 2014-03-21T14:27:07Z cellular_component owl:Class
GO:0002780 biolink:NamedThing antibacterial peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antibacterial peptide. got7fsn_ti biological_process owl:Class
GO:0047616 biolink:NamedThing acyl-CoA dehydrogenase (NADP+) activity Catalysis of the reaction: acyl-CoA + NADP+ = 2,3-dehydroacyl-CoA + NADPH + H+. got7fsn_ti 2-enoyl-CoA reductase activity|acyl-CoA:NADP+ 2-oxidoreductase activity|dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)|crotonyl coenzyme A reductase activity|enoyl coenzyme A reductase activity RHEA:22460|MetaCyc:ACYL-COA-DEHYDROGENASE-NADP+-RXN|EC:1.3.1.8 molecular_function owl:Class
GO:0015475 biolink:NamedThing adhesin autotransporter activity Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively. got7fsn_ti molecular_function owl:Class
GO:0140295 biolink:NamedThing pathogen-derived receptor ligand activity The activity of a pathogen-derived entity that interacts with a host receptor to activate effector-triggered immunity. got7fsn_ti innate receptor ligand activity https://github.com/geneontology/go-ontology/issues/16656|https://github.com/geneontology/go-ontology/issues/19194 Note that this term is meant to annotate effectors for which the evolved activity is to act as a ligand to activate (for necrotrophs) or suppress (for biotrophs) the host immune system. It should not be used to annotate PAMPs (pathogen-associated molecular pattern molecules) or similar types of microbial proteins recognized by the host innate immune system (for example, PAMPs are recognized by toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals). PAMPs activate innate immune responses, protecting the host from infection, but this is not the molecular function of PAMPs; those usually form the structure of the bacterial cell wall. pg 2018-11-26T13:30:21Z molecular_function owl:Class
GO:0051225 biolink:NamedThing spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. got7fsn_ti bipolar spindle formation|bipolar spindle biosynthesis|spindle biosynthesis|spindle formation GO:0051226|GO:0051227 biological_process owl:Class
GO:0048183 biolink:NamedThing activin AB complex A nonsteroidal regulator, composed of two covalently linked inhibin beta subunits (sometimes known as activin beta or activin/inhibin beta), inhibin beta-A and inhibin beta-B. got7fsn_ti inhibin beta-B|inhibin beta-A Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and a inhibin alpha subunit. See 'inhibin complex ; GO:0043511'. cellular_component owl:Class
GO:0018203 biolink:NamedThing peptidyl-isoleucine modification The modification of peptidyl-isoleucine. got7fsn_ti biological_process owl:Class
GO:0030888 biolink:NamedThing regulation of B cell proliferation Any process that modulates the frequency, rate or extent of B cell proliferation. got7fsn_ti regulation of B-lymphocyte proliferation|regulation of B lymphocyte proliferation|regulation of B-cell proliferation biological_process owl:Class
GO:0016167 biolink:NamedThing glial cell-derived neurotrophic factor receptor activity Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti GDNF receptor activity|glial cell line-derived neurotrophic factor receptor activity molecular_function owl:Class
GO:0001092 biolink:NamedThing TFIIA-class transcription factor complex binding Binding to a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. got7fsn_ti TFIIA-class transcription factor binding krc 2010-10-28T02:37:19Z molecular_function owl:Class
GO:0036012 biolink:NamedThing cyanelle inner membrane The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma. got7fsn_ti cyanelle inner envelope membrane bf 2011-10-10T01:48:56Z cellular_component owl:Class
GO:0014890 biolink:NamedThing smooth muscle atrophy A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. got7fsn_ti biological_process owl:Class
GO:0044510 biolink:NamedThing envenomation resulting in positive regulation of signal transduction in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism. got7fsn_ti jl 2012-02-23T05:03:22Z biological_process owl:Class
GO:0044509 biolink:NamedThing envenomation resulting in modulation of signal transduction in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism. got7fsn_ti jl 2012-02-23T04:58:10Z biological_process owl:Class
GO:0060480 biolink:NamedThing lung goblet cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lung goblet cell. A goblet cell is a cell of the epithelial lining that produces and secretes mucins. got7fsn_ti pulmonary goblet cell differentiation biological_process owl:Class
GO:0000476 biolink:NamedThing maturation of 4.5S rRNA Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule. got7fsn_ti biological_process owl:Class
GO:0003129 biolink:NamedThing heart induction The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart. got7fsn_ti tb 2009-09-22T02:58:41Z biological_process owl:Class
GO:0097643 biolink:NamedThing amylin receptor activity Combining with amylin to initiate a change in cell activity. got7fsn_ti pr 2014-09-08T15:34:16Z molecular_function owl:Class
GO:0051501 biolink:NamedThing diterpene phytoalexin metabolic process The chemical reactions and pathways involving diterpene phytoalexins, a class of diterpene formed in plants in response to fungal infection, physical damage, chemical injury, or a pathogenic process; they are sometimes referred to as plant antibiotics. Diterpenes are unsaturated hydrocarbons containing 20 carbon atoms and 4 branched methyl groups and are made up of isoprenoid units. got7fsn_ti diterpene phytoalexin metabolism biological_process owl:Class
GO:0045180 biolink:NamedThing basal cortex The region that lies just beneath the plasma membrane on the basal edge of a cell. got7fsn_ti cellular_component owl:Class
GO:0080028 biolink:NamedThing nitrile biosynthetic process The chemical reactions and pathways resulting in the formation of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom. got7fsn_ti biological_process owl:Class
GO:0106383 biolink:NamedThing dAMP salvage Any process which produces a dAMP from derivatives of it, without de novo synthesis. got7fsn_ti hjd 2021-06-11T16:51:09Z biological_process owl:Class
GO:0048240 biolink:NamedThing sperm capacitation A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium. got7fsn_ti sperm activation Avian spermatozoa do not require a period of capacitation, since they are competent to fertilize the egg without a prolonged sojourn in the oviduct or in a capacitation medium in vitro. Therefore, sperm capacitation can only be applied to Aves to refer to gene products involved in processes that occur prior to sperm being deposited from the avian male. The term cannot apply to processes occurring in the avian female reproductive tract. biological_process owl:Class
GO:0034559 biolink:NamedThing bisphenol A hydroxylase B activity Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 1,2-bis(4-hydroxyphenyl)-2-propanol + NAD+ + H2O. got7fsn_ti UM-BBD_reactionID:r0860 molecular_function owl:Class
GO:0010473 biolink:NamedThing GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol. got7fsn_ti molecular_function owl:Class
GO:0090017 biolink:NamedThing anterior neural plate formation The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate. got7fsn_ti tb 2009-07-29T11:31:35Z biological_process owl:Class
GO:0103039 biolink:NamedThing protein methylthiotransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [ribosomal protein S12] L-aspartate89 + a sulfurated [sulfur carrier] + a reduced electron acceptor = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2 H+ + a [ribosomal protein S12] 3-methylthio-L-aspartate89 + an unsulfurated [sulfur carrier] + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN0-6366|RHEA:37087|EC:2.8.4.4 molecular_function owl:Class
GO:0070823 biolink:NamedThing HDA1 complex A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p. got7fsn_ti mah 2009-07-20T04:47:11Z cellular_component owl:Class
GO:0008777 biolink:NamedThing acetylornithine deacetylase activity Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine. got7fsn_ti N2-acetyl-L-ornithine amidohydrolase activity|2-N-acetyl-L-ornithine amidohydrolase activity|acetylornithinase activity|N-acetylornithinase activity EC:3.5.1.16|MetaCyc:ACETYLORNDEACET-RXN|RHEA:15941 molecular_function owl:Class
GO:0102892 biolink:NamedThing betanidin 5-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + betanin + UDP. got7fsn_ti MetaCyc:RXN-8479 molecular_function owl:Class
GO:0002023 biolink:NamedThing reduction of food intake in response to dietary excess An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients. got7fsn_ti biological_process owl:Class
GO:0050409 biolink:NamedThing indolylacetylinositol arabinosyltransferase activity Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP. got7fsn_ti UDP-L-arabinose:(indol-3-yl)acetyl-myo-inositol L-arabinosyltransferase activity|UDP-L-arabinose:indol-3-ylacetyl-myo-inositol L-arabinosyltransferase activity|arabinosylindolylacetylinositol synthase activity MetaCyc:2.4.2.34-RXN|KEGG_REACTION:R04335|EC:2.4.2.34|RHEA:19505 molecular_function owl:Class
GO:0052636 biolink:NamedThing arabinosyltransferase activity Catalysis of the transfer of an arabinosyl group from one compound (donor) to another (acceptor). got7fsn_ti arabinosyl transferase activity molecular_function owl:Class
GO:0018883 biolink:NamedThing caprolactam metabolic process The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation. got7fsn_ti caprolactam metabolism UM-BBD_pathwayID:cap biological_process owl:Class
GO:0140034 biolink:NamedThing methylation-dependent protein binding Binding to a protein upon methylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require methylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of methylation. It may be that the methylation causes a conformational change that allows binding of the protein to another region; this type of methylation-dependent protein binding is valid for annotation to this term. pg 2017-05-17T15:40:02Z molecular_function owl:Class
GO:0072588 biolink:NamedThing box H/ACA RNP complex A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex. got7fsn_ti sRNP complex|box H/ACA snoRNP pseudouridylase complex https://github.com/geneontology/go-ontology/issues/20416 mah 2011-02-10T01:43:37Z cellular_component owl:Class
GO:0007187 biolink:NamedThing G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. got7fsn_ti GPCR signaling pathway via cyclic nucleotide second messenger|G protein signaling, coupled to cyclic nucleotide second messenger|G-protein signalling, coupled to cyclic nucleotide second messenger|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|G-protein signaling, coupled to cyclic nucleotide second messenger|G protein signalling, coupled to cyclic nucleotide second messenger biological_process owl:Class
GO:0003947 biolink:NamedThing (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide. got7fsn_ti ganglioside GM3 acetylgalactosaminyltransferase activity|GalNAc-T activity|ganglioside GM2 synthase activity|GM2 synthase activity|uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity|beta-1,4N-aetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity|UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity|GM2/GD2-synthase activity|UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity|asialo-GM2 synthase activity MetaCyc:2.4.1.92-RXN|RHEA:12588|Reactome:R-HSA-8856223|EC:2.4.1.92 molecular_function owl:Class
GO:0018530 biolink:NamedThing (R)-6-hydroxynicotine oxidase activity Catalysis of the reaction: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2). got7fsn_ti D-6-hydroxynicotine oxidase activity|(R)-6-hydroxynicotine:oxygen oxidoreductase activity|6-hydroxy-D-nicotine oxidase activity MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN|RHEA:10012|UM-BBD_reactionID:r0477|EC:1.5.3.6|KEGG_REACTION:R07170 molecular_function owl:Class
GO:0052650 biolink:NamedThing NADP-retinol dehydrogenase activity Catalysis of the reaction: all-trans-retinol + NADP+ = all-trans-retinal + NADPH + H+. got7fsn_ti retinol:NADP+ oxidoreductase activity|NADP(H)-dependent retinol dehydrogenase/reductase activity|retinol dehydrogenase activity|all-trans-retinol dehydrogenase activity|retinol dehydrogenase [NADP+] activity|all-trans retinal reductase activity Reactome:R-HSA-2471670|Reactome:R-HSA-5615668|KEGG_REACTION:R08379|Reactome:R-HSA-2465940|EC:1.1.1.300|Reactome:R-HSA-2466861|Reactome:R-HSA-2464803|MetaCyc:RXN-10841|Reactome:R-HSA-5419165|Reactome:R-HSA-2464822|Reactome:R-HSA-2465921|RHEA:25033|Reactome:R-HSA-5623643|Reactome:R-HSA-74872 molecular_function owl:Class
GO:0005600 biolink:NamedThing collagen type XIII trimer A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0098549 biolink:NamedThing somatic ring canal A stable intercellular bridge between somatic cells. Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects. got7fsn_ti cellular_component owl:Class
GO:0071088 biolink:NamedThing alpha5-beta1 integrin-tissue transglutaminase complex A protein complex that consists of an alpha5-beta1 integrin complex bound to tissue transglutaminase. got7fsn_ti ITGA5-ITGB1-TGM2 complex mah 2009-11-06T04:45:47Z cellular_component owl:Class
GO:0035988 biolink:NamedThing chondrocyte proliferation The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage. got7fsn_ti chondrocyte cell proliferation|cartilage cell proliferation bf 2011-08-25T04:53:40Z biological_process owl:Class
GO:0052072 biolink:NamedThing induction by symbiont of defense-related host salicylic acid-mediated signal transduction pathway Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|upregulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|activation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|up regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|stimulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|upregulation by organism of defense-related host SA-mediated signal transduction pathway|positive regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|induction by organism of defense-related host salicylic acid-mediated signal transduction pathway|up-regulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway|induction by organism of defense-related host SA-mediated signal transduction pathway|activation by organism of defense-related host salicylic acid-mediated signal transduction pathway|activation by organism of defense-related host SA-mediated signal transduction pathway|upregulation by organism of defense-related host salicylic acid-mediated signal transduction pathway|positive regulation by organism of defense-related host SA-mediated signal transduction pathway GO:0052270 biological_process owl:Class
GO:1990328 biolink:NamedThing RPB4-RPB7 complex A protein complex that cycles between the nucleus where it is part of the RNA polymerase II and the cytoplasmic mRNA processing body where it mediates the two major cytoplasmic mRNA decay pathways. got7fsn_ti RNA polymerase II, RPB4-RPB7 subcomplex https://github.com/geneontology/go-ontology/issues/10931 bhm 2014-03-17T09:37:07Z cellular_component owl:Class
GO:0008134 biolink:NamedThing transcription factor binding Binding to a transcription factor, a protein required to initiate or regulate transcription. got7fsn_ti TF binding https://github.com/geneontology/go-ontology/issues/19354 Note that this term should not be used for direct annotation. Please consier one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding. molecular_function owl:Class
GO:0019147 biolink:NamedThing (R)-aminopropanol dehydrogenase activity Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH. got7fsn_ti (R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity|L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity|1-aminopropan-2-ol-NAD+ dehydrogenase activity|1-aminopropan-2-ol-dehydrogenase activity|DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity|L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity|L-aminopropanol dehydrogenase activity RHEA:16517|KEGG_REACTION:R03759|EC:1.1.1.75|MetaCyc:AMINOPROPDEHYDROG-RXN molecular_function owl:Class
GO:0051976 biolink:NamedThing lysine biosynthetic process via alpha-aminoadipate and N2-acetyl-alpha-aminoadipate The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and N2-acetyl-alpha-aminoadipate. This pathway of prokaryotic lysine biosynthesis via alpha-aminoadipate was discovered in the hyper-thermophilic Gram-negative eubacterium Thermus thermophilus. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This undergoes acetylation, to form N2-acetyl-alpha-aminoadipate, and is then phosphorylated to give N2-acetyl-alpha-aminoadipyl-delta-phosphate. This is converted to N2-acetyl-alpha-aminoadipate semialdehyde, which is then converted to N2-acetyl-L-lysine. A final deacetylation reaction produces L-lysine. got7fsn_ti lysine biosynthetic process via aminoadipic acid and N2-acetyl-alpha-aminoadipate|lysine biosynthesis via aminoadipic acid and N2-acetyl-alpha-aminoadipate MetaCyc:PWY-3081 biological_process owl:Class
GO:0034827 biolink:NamedThing 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r1171 molecular_function owl:Class
GO:0050166 biolink:NamedThing pantoate 4-dehydrogenase activity Catalysis of the reaction: (R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH. got7fsn_ti (R)-pantoate:NAD+ 4-oxidoreductase activity|pantoate dehydrogenase activity|panthothenase activity|D-pantoate:NAD+ 4-oxidoreductase activity KEGG_REACTION:R02471|EC:1.1.1.106|RHEA:23000|MetaCyc:PANTOATE-4-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0019401 biolink:NamedThing alditol biosynthetic process The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. got7fsn_ti alditol synthesis|alditol anabolism|alditol formation|alditol biosynthesis biological_process owl:Class
GO:1900821 biolink:NamedThing orlandin biosynthetic process The chemical reactions and pathways resulting in the formation of orlandin. got7fsn_ti orlandin synthesis|orlandin anabolism|orlandin formation|orlandin biosynthesis di 2012-06-04T10:15:24Z biological_process owl:Class
GO:0042602 biolink:NamedThing riboflavin reductase (NADPH) activity Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+. got7fsn_ti riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|reduced-riboflavin:NADP+ oxidoreductase activity|NADPH:riboflavin oxidoreductase activity|riboflavine mononucleotide reductase activity|riboflavin mononucleotide reductase activity|NADPH-riboflavin oxidoreductase activity|NADPH-specific FMN reductase activity|NADPH-FMN reductase activity|NADPH2 dehydrogenase (riboflavin)|NADPH-dependent FMN reductase activity|NADPH2:riboflavin oxidoreductase activity|NADPH-riboflavin reductase activity|flavin reductase activity|NADPH dehydrogenase (riboflavin) activity|FMN reductase (NADPH) activity KEGG_REACTION:R05707|EC:1.5.1.41|MetaCyc:NADPH-DEHYDROGENASE-FLAVIN-RXN|EC:1.5.1.30|RHEA:19377 molecular_function owl:Class
GO:0044202 biolink:NamedThing host cell nuclear outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes. got7fsn_ti jl 2009-10-21T11:10:23Z cellular_component owl:Class
GO:0102435 biolink:NamedThing myricetin 7-O-methyltransferase activity Catalysis of the reaction: myricetin(1-) + S-adenosyl-L-methionine <=> 7-O-methylmyricetin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13910 molecular_function owl:Class
GO:0044759 biolink:NamedThing negative regulation by symbiont of host synaptic transmission Any process in which a symbiont organism decreases the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism. got7fsn_ti jl 2012-12-06T15:37:25Z biological_process owl:Class
GO:0021517 biolink:NamedThing ventral spinal cord development The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output. got7fsn_ti biological_process owl:Class
GO:0090542 biolink:NamedThing ELYC domain binding Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC. got7fsn_ti tb 2013-02-14T17:11:29Z molecular_function owl:Class
GO:0018726 biolink:NamedThing 9-phenanthrol sulfotransferase activity Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate. got7fsn_ti 9-phenanthrol sulphotransferase activity UM-BBD_reactionID:r0564 molecular_function owl:Class
GO:0019894 biolink:NamedThing kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. got7fsn_ti molecular_function owl:Class
GO:0102768 biolink:NamedThing anthocyanidin synthase activity Catalysis of the reaction: flavan-3,3',4,4',5,5',7-heptol + O2 + 2-oxoglutarate = H+ + delphinidin + 2 H2O + carbon dioxide + succinate. got7fsn_ti MetaCyc:RXN-7785 molecular_function owl:Class
GO:0009851 biolink:NamedThing auxin biosynthetic process The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth. got7fsn_ti auxin formation|auxin biosynthesis|auxin synthesis|auxin anabolism biological_process owl:Class
GO:0050324 biolink:NamedThing taurocyamine kinase activity Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H(+). got7fsn_ti ATP:taurocyamine phosphotransferase activity|taurocyamine phosphotransferase activity|ATP:taurocyamine N-phosphotransferase activity EC:2.7.3.4|RHEA:22516|MetaCyc:TAUROCYAMINE-KINASE-RXN|KEGG_REACTION:R03785 molecular_function owl:Class
GO:0050054 biolink:NamedThing lignostilbene alpha beta-dioxygenase activity Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin. got7fsn_ti lignostilbene alphabeta-dioxygenase activity|lignostilbene ab-dioxygenase activity|1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene:oxygen oxidoreductase (alphabeta-bond-cleaving) MetaCyc:LIGNOSTILBENE-ALPHA-BETA-DIOXYGENASE-RXN|EC:1.13.11.43|RHEA:21340|KEGG_REACTION:R00043 molecular_function owl:Class
GO:0030954 biolink:NamedThing astral microtubule nucleation The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. got7fsn_ti biological_process owl:Class
GO:0102987 biolink:NamedThing palmitoleic acid delta 12 desaturase activity Catalysis of the reaction: palmitoleoyl-CoA + O2 + a reduced electron acceptor <=> (9Z,12Z)-hexadecadienoyl-CoA + 2 H2O + an oxidized electron acceptor. got7fsn_ti RHEA:45096|MetaCyc:RXN-9616 molecular_function owl:Class
GO:0008356 biolink:NamedThing asymmetric cell division The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity. got7fsn_ti asymmetrical cell division|asymmetrical cytokinesis|asymmetric cytokinesis Wikipedia:Asymmetric_cell_division biological_process owl:Class
GO:0001540 biolink:NamedThing amyloid-beta binding Binding to an amyloid-beta peptide/protein. got7fsn_ti beta-amyloid binding https://github.com/geneontology/go-ontology/issues/20109 molecular_function owl:Class
GO:0052793 biolink:NamedThing pectin acetylesterase activity Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin. got7fsn_ti ai 2011-10-05T05:17:21Z molecular_function owl:Class
GO:0016688 biolink:NamedThing L-ascorbate peroxidase activity Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O. got7fsn_ti L-ascorbic acid peroxidase activity|L-ascorbic acid-specific peroxidase activity|L-ascorbate:hydrogen-peroxide oxidoreductase activity|ascorbic acid peroxidase activity|ascorbate peroxidase activity MetaCyc:L-ASCORBATE-PEROXIDASE-RXN|RHEA:22996|EC:1.11.1.11 molecular_function owl:Class
GO:0070155 biolink:NamedThing mitochondrial methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA in a mitochondrion, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0050739 biolink:NamedThing peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium. got7fsn_ti RESID:AA0348 biological_process owl:Class
GO:0140451 biolink:NamedThing counting factor complex A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19220 pg 2020-04-15T08:52:26Z cellular_component owl:Class
GO:1902539 biolink:NamedThing multi-organism macropinocytosis A macropinocytosis which involves another organism. got7fsn_ti jl 2013-12-02T14:23:06Z biological_process owl:Class
GO:0050077 biolink:NamedThing maleylpyruvate isomerase activity Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate. got7fsn_ti 3-maleylpyruvate cis-trans-isomerase activity RHEA:17393|MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN|EC:5.2.1.4 molecular_function owl:Class
GO:0003156 biolink:NamedThing regulation of animal organ formation Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. got7fsn_ti tb 2009-09-30T11:21:09Z biological_process owl:Class
GO:0102830 biolink:NamedThing verbascose synthase activity Catalysis of the reaction: 2 stachyose <=> verbascose + raffinose. got7fsn_ti MetaCyc:RXN-8286 molecular_function owl:Class
GO:0052021 biolink:NamedThing modulation by symbiont of ethylene levels in host The alteration by an organism of the levels of ethylene in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of ethylene levels in other organism involved in symbiotic interaction GO:0052449 biological_process owl:Class
GO:0075202 biolink:NamedThing regulation of penetration hypha formation Any process that modulates the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation of symbiont penetration hypha formation for entry into host https://github.com/geneontology/go-ontology/issues/21121 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0140067 biolink:NamedThing peptidyl-lysine butyrylation The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid. got7fsn_ti pg 2017-07-20T16:52:19Z biological_process owl:Class
GO:1990849 biolink:NamedThing maintenance of vacuolar location Any process in which the vacuole is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of vacuole location|maintenance of vacuolar localization|maintenance of vacuole localization mcc 2015-09-10T08:16:02Z biological_process owl:Class
GO:0070618 biolink:NamedThing Grb2-Sos complex A protein complex that contains Grb2 and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. got7fsn_ti Grb2-mSos1 complex mah 2009-04-29T04:19:02Z cellular_component owl:Class
GO:0016524 biolink:NamedThing latrotoxin receptor activity Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti latrophilin molecular_function owl:Class
GO:0044379 biolink:NamedThing protein localization to actin cortical patch A process in which a protein is transported to, or maintained in, an actin cortical patch. got7fsn_ti protein localisation to actin cortical patch jl 2011-12-08T02:28:42Z biological_process owl:Class
GO:0102370 biolink:NamedThing lupeol 28-monooxygenase activity Catalysis of the reaction: lupeol + NADPH(4-) + O2 + H+ <=> betulin + NADP(3-) + H2O. got7fsn_ti MetaCyc:RXN-13497 molecular_function owl:Class
GO:0048545 biolink:NamedThing response to steroid hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. got7fsn_ti response to steroid hormone stimulus biological_process owl:Class
GO:0033782 biolink:NamedThing 24-hydroxycholesterol 7alpha-hydroxylase activity Catalysis of the reaction: (24S)-hydroxycholesterol + O2 + reduced [NADPH-hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. got7fsn_ti 24-hydroxycholesterol 7alpha-monooxygenase activity|24-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating) activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.14.13.99. MetaCyc:1.14.13.99-RXN|KEGG_REACTION:R07208|EC:1.14.14.26|RHEA:46124 molecular_function owl:Class
GO:0006463 biolink:NamedThing steroid hormone receptor complex assembly The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor. got7fsn_ti biological_process owl:Class
GO:0075341 biolink:NamedThing host cell PML body A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism. got7fsn_ti host cell PML nuclear body|host cell PML NB cellular_component owl:Class
GO:0102835 biolink:NamedThing 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8295|EC:1.14.19.35 molecular_function owl:Class
GO:0004815 biolink:NamedThing aspartate-tRNA ligase activity Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). got7fsn_ti L-aspartate:tRNAAsp ligase (AMP-forming)|aspartyl ribonucleic synthetase activity|aspartyl-tRNA synthetase activity|aspartyl-transfer RNA synthetase activity|aspartyl ribonucleate synthetase activity|aspartic acid translase activity|aspartyl-transfer ribonucleic acid synthetase activity MetaCyc:ASPARTATE--TRNA-LIGASE-RXN|Reactome:R-HSA-380229|Reactome:R-HSA-379867|EC:6.1.1.12|RHEA:19649 molecular_function owl:Class
GO:0030648 biolink:NamedThing aminoglycoside antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. got7fsn_ti aminoglycoside antibiotic anabolism|aminoglycoside antibiotic biosynthesis|aminoglycoside antibiotic synthesis|aminoglycoside antibiotic formation biological_process owl:Class
GO:1900604 biolink:NamedThing tensidol A catabolic process The chemical reactions and pathways resulting in the breakdown of tensidol A. got7fsn_ti tensidol A degradation|tensidol A catabolism|tensidol A breakdown di 2012-05-15T06:58:09Z biological_process owl:Class
GO:0055122 biolink:NamedThing response to very low light intensity stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec. got7fsn_ti biological_process owl:Class
GO:0047793 biolink:NamedThing cycloeucalenol cycloisomerase activity Catalysis of the reaction: cycloeucalenol = obtusifoliol. got7fsn_ti cycloeucalenol lyase (cyclopropane-decyclizing)|cycloeucalenol--obtusifoliol isomerase activity|cycloeucalenol-obtusifoliol isomerase activity MetaCyc:CYCLOEUCALENOL-CYCLOISOMERASE-RXN|EC:5.5.1.9|KEGG_REACTION:R03775|RHEA:22800 molecular_function owl:Class
GO:0015599 biolink:NamedThing ATPase-coupled L-glutamine transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in). got7fsn_ti glutamine-importing ATPase activity|glutamine porter activity|ATPase-coupled glutamine transmembrane transporter activity MetaCyc:ABC-12-RXN|EC:7.4.2.1 molecular_function owl:Class
GO:0015186 biolink:NamedThing L-glutamine transmembrane transporter activity Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. got7fsn_ti asparagine/glutamine permease activity molecular_function owl:Class
GO:0021740 biolink:NamedThing principal sensory nucleus of trigeminal nerve development The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure. got7fsn_ti pontine nucleus development Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions. biological_process owl:Class
GO:1990792 biolink:NamedThing cellular response to glial cell derived neurotrophic factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus. got7fsn_ti cellular response to astrocyte-derived trophic factor|cellular response to GDNF|cellular response to ATF sl 2015-07-06T15:27:38Z biological_process owl:Class
GO:0071542 biolink:NamedThing dopaminergic neuron differentiation The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine. got7fsn_ti mah 2010-01-12T02:28:44Z biological_process owl:Class
GO:0045128 biolink:NamedThing negative regulation of reciprocal meiotic recombination Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. got7fsn_ti inhibition of meiotic recombination|down regulation of meiotic recombination|down-regulation of meiotic recombination|downregulation of meiotic recombination|suppression of meiotic recombination biological_process owl:Class
GO:0045835 biolink:NamedThing negative regulation of meiotic nuclear division Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis. got7fsn_ti downregulation of meiosis|down-regulation of meiosis|down regulation of meiosis|inhibition of meiosis|negative regulation of meiosis biological_process owl:Class
GO:0080017 biolink:NamedThing alpha-humulene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = alpha-humulene + diphosphate. got7fsn_ti EC:4.2.3.104|RHEA:31895|MetaCyc:RXN-8415 molecular_function owl:Class
GO:0097648 biolink:NamedThing G protein-coupled receptor complex A protein complex that contains G protein-coupled receptors. got7fsn_ti G-protein coupled receptor complex pr 2014-09-10T09:14:30Z cellular_component owl:Class
GO:0021759 biolink:NamedThing globus pallidus development The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain. got7fsn_ti pallidum development biological_process owl:Class
GO:0004729 biolink:NamedThing oxygen-dependent protoporphyrinogen oxidase activity Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX. got7fsn_ti protoporphyrinogen-IX:oxygen oxidoreductase activity RHEA:25576|KEGG_REACTION:R03222|EC:1.3.3.4|Reactome:R-HSA-189423|MetaCyc:PROTOPORGENOXI-RXN molecular_function owl:Class
GO:0050404 biolink:NamedThing zeatin O-beta-D-xylosyltransferase activity Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H(+) + UDP. got7fsn_ti uridine diphosphoxylose-zeatin xylosyltransferase activity|zeatin O-b-D-xylosyltransferase activity|UDP-D-xylose:zeatin O-beta-D-xylosyltransferase activity|zeatin O-xylosyltransferase activity Note that this function was formerly EC:2.4.1.204. EC:2.4.2.40|KEGG_REACTION:R02119|RHEA:14721|MetaCyc:ZEATIN-O-BETA-D-XYLOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0035510 biolink:NamedThing DNA dealkylation The removal of an alkyl group from one or more nucleotides within an DNA molecule. got7fsn_ti bf 2010-04-30T02:20:08Z biological_process owl:Class
GO:0102135 biolink:NamedThing (22S)-22-hydroxy-campest-4-en-3-one C-23 hydroxylase activity Catalysis of the reaction: H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH + O2 <=> (22R,23R)-22,23-dihydroxy-campest-4-en-3-one + NADP + H2O. got7fsn_ti MetaCyc:RXN-11530 molecular_function owl:Class
GO:0047712 biolink:NamedThing Cypridina-luciferin 2-monooxygenase activity Catalysis of the reaction: Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light. got7fsn_ti luciferase activity|luciferase (Cypridina luciferin)|Cypridina luciferase activity|Cypridina-luciferin:oxygen 2-oxidoreductase (decarboxylating)|Cypridina-type luciferase activity EC:1.13.12.6|RHEA:22760|MetaCyc:CYPRIDINA-LUCIFERIN-2-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0030338 biolink:NamedThing CMP-N-acetylneuraminate monooxygenase activity Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O. got7fsn_ti cytidine monophosphoacetylneuraminate monooxygenase activity|CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)|cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity|CMP-N-acetylneuraminic acid hydroxylase activity|CMP-N-acetylneuraminate hydroxylase activity|N-acetylneuraminic monooxygenase activity|CMP-Neu5Ac hydroxylase activity Note that this was EC:1.14.13.45. MetaCyc:1.14.13.45-RXN|RHEA:16145|EC:1.14.18.2 molecular_function owl:Class
GO:0030841 biolink:NamedThing positive regulation of intermediate filament polymerization Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization. got7fsn_ti positive regulation of intermediate filament polymerization and/or depolymerization|upregulation of intermediate filament polymerization|up regulation of intermediate filament polymerization|up-regulation of intermediate filament polymerization|activation of intermediate filament polymerization|stimulation of intermediate filament polymerization Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844'). biological_process owl:Class
GO:0043888 biolink:NamedThing (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate. got7fsn_ti UbiA|DGGGP synthase activity|2,3-dGGGPS|DGGGPS This function is involved in archaeal lipid synthesis. EC:2.5.1.- molecular_function owl:Class
GO:0004337 biolink:NamedThing geranyltranstransferase activity Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate. got7fsn_ti farnesyl-diphosphate synthase activity|geranyl transferase I|farnesylpyrophosphate synthetase activity|geranyltransferase activity|FPP synthetase activity|geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity|farnesyl pyrophosphate synthetase activity|farnesyl diphosphate synthetase activity Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. Reactome:R-HSA-8870469|MetaCyc:FPPSYN-RXN|Reactome:R-HSA-191303|KEGG_REACTION:R02003|EC:2.5.1.10|RHEA:19361 molecular_function owl:Class
GO:0033960 biolink:NamedThing N-methyl nucleosidase activity Catalysis of the reaction: 7-methylxanthosine + H(2)O = 7-methylxanthine + H(+) + ribofuranose. got7fsn_ti methylpurine nucleosidase activity|N-methyl nucleoside hydrolase activity|N-MeNase activity|7-methylxanthosine ribohydrolase activity|7-methylxanthosine nucleosidase activity MetaCyc:RXN-7597|KEGG_REACTION:R07918|RHEA:10880|EC:3.2.2.25 molecular_function owl:Class
GO:0060703 biolink:NamedThing deoxyribonuclease inhibitor activity Binds to and stops, prevents or reduces the activity of deoxyribonuclease. got7fsn_ti DNase inhibitor activity dph 2009-06-08T03:00:35Z molecular_function owl:Class
GO:0044805 biolink:NamedThing late nucleophagy A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM. got7fsn_ti LN jl 2013-09-10T15:58:23Z biological_process owl:Class
GO:0044804 biolink:NamedThing autophagy of nucleus A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. got7fsn_ti nucleophagy|nucleus degradation jl 2013-09-10T15:50:25Z biological_process owl:Class
GO:0036431 biolink:NamedThing dCMP kinase activity Catalysis of the reaction: ATP + dCMP = ADP + dCDP. got7fsn_ti ATP:dCMP phosphotransferase activity bf 2013-09-16T14:11:56Z RHEA:25094|MetaCyc:RXN-7913|KEGG_REACTION:R01665|MetaCyc:RXN-11831 molecular_function owl:Class
GO:0004127 biolink:NamedThing cytidylate kinase activity Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP. got7fsn_ti CMP kinase activity|ATP:CMP phosphotransferase activity|CTP:CMP phosphotransferase activity|pyrimidine nucleoside monophosphate kinase activity|dCMP kinase activity|ATP:UMP-CMP phosphotransferase activity|deoxycytidylate kinase activity|deoxycytidine monophosphokinase activity|UMP-CMP kinase activity|cytidine monophosphate kinase activity MetaCyc:CMPKI-RXN|EC:2.7.4.14 molecular_function owl:Class
GO:2000543 biolink:NamedThing positive regulation of gastrulation Any process that activates or increases the frequency, rate or extent of gastrulation. got7fsn_ti yaf 2011-04-01T04:10:15Z biological_process owl:Class
GO:0002239 biolink:NamedThing response to oomycetes Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes. got7fsn_ti biological_process owl:Class
GO:0070421 biolink:NamedThing DNA ligase III-XRCC1 complex A protein complex that contains DNA ligase III and XRCC1, and is involved in base excision repair. got7fsn_ti cellular_component owl:Class
GO:0015334 biolink:NamedThing high-affinity oligopeptide transmembrane transporter activity Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. got7fsn_ti high affinity oligopeptide transporter activity|high-affinity oligopeptide transporter activity molecular_function owl:Class
GO:0035673 biolink:NamedThing oligopeptide transmembrane transporter activity Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. got7fsn_ti oligopeptide transporter activity bf 2011-02-08T02:20:14Z GO:0015198 molecular_function owl:Class
GO:0072449 biolink:NamedThing response to G1 cell size control checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling. got7fsn_ti mitotic cell cycle G1/S transition size control checkpoint effector process|response to signal involved in mitotic cell cycle G1/S transition size control checkpoint mah 2010-12-09T10:56:39Z biological_process owl:Class
GO:0072470 biolink:NamedThing response to cell size control checkpoint signaling A process that occurs in response to signals generated as a result of cell size control checkpoint signaling. got7fsn_ti response to mitotic cell cycle cell size control checkpoint signaling|cell size control checkpoint effector process|response to signal involved in cell size control checkpoint mah 2010-12-09T11:46:13Z biological_process owl:Class
GO:0034780 biolink:NamedThing glyphosate dehydrogenase activity Catalysis of the reaction: glyphosate + OH- = glyoxylate + aminomethylphosphonic acid + H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0073 molecular_function owl:Class
GO:0047065 biolink:NamedThing sulochrin oxidase [(-)-bisdechlorogeodin-forming] activity Catalysis of the reaction: O(2) + 2 sulochrin = 2 (2R)-bisdechlorogeodin + 2 H(2)O. got7fsn_ti sulochrin:oxygen oxidoreductase (cyclizing, (-)-specific)|sulochrin oxidase activity EC:1.21.3.5|RHEA:22616|KEGG_REACTION:R00061|MetaCyc:1.10.3.8-RXN molecular_function owl:Class
GO:0019975 biolink:NamedThing interleukin-17 binding Binding to a member of the interleukin-17 family of cytokines. got7fsn_ti IL-17 binding molecular_function owl:Class
GO:0005722 biolink:NamedThing beta-heterochromatin A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization. got7fsn_ti cellular_component owl:Class
GO:0019781 biolink:NamedThing NEDD8 activating enzyme activity Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade. got7fsn_ti RUB1 activating enzyme activity GO:0019944 molecular_function owl:Class
GO:0032578 biolink:NamedThing aleurone grain membrane The lipid bilayer surrounding an aleurone grain. got7fsn_ti cellular_component owl:Class
GO:0050472 biolink:NamedThing zeatin reductase activity Catalysis of the reaction: dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin. got7fsn_ti dihydrozeatin:NADP+ oxidoreductase activity KEGG_REACTION:R05702|MetaCyc:ZEATIN-REDUCTASE-RXN|EC:1.3.1.69|RHEA:12757 molecular_function owl:Class
GO:0060532 biolink:NamedThing bronchus cartilage development The process whose specific outcome is the progression of lung cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. got7fsn_ti pulmonary cartilage development dph 2009-04-10T08:12:06Z biological_process owl:Class
GO:0034025 biolink:NamedThing D-aspartate ligase activity Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate. got7fsn_ti aslfm|D-aspartic acid-activating enzyme|D-aspartate:[beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n ligase (ADP-forming) activity|UDP-MurNAc-pentapeptide:D-aspartate ligase activity RHEA:10752|EC:6.3.1.12|MetaCyc:6.3.1.12-RXN molecular_function owl:Class
GO:0005602 biolink:NamedThing complement component C1 complex A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains. got7fsn_ti complement component C1q complex cellular_component owl:Class
GO:1901318 biolink:NamedThing negative regulation of flagellated sperm motility Any process that stops, prevents or reduces the frequency, rate or extent of flagellated sperm motility. got7fsn_ti inhibition of sperm motility|downregulation of sperm movement|down regulation of sperm movement|negative regulation of sperm movement|inhibition of sperm movement|down-regulation of sperm movement|downregulation of sperm motility|down-regulation of sperm motility|down regulation of sperm motility|negative regulation of sperm motility hjd 2012-08-22T20:50:35Z biological_process owl:Class
GO:0007506 biolink:NamedThing gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism. got7fsn_ti biological_process owl:Class
GO:0002949 biolink:NamedThing tRNA threonylcarbamoyladenosine modification The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). got7fsn_ti t6A biosynthesis|threonylcarbamoyladenosine anabolism|t6A tRNA modification|threonylcarbamoyladenosine biosynthetic process|threonylcarbamoyladenosine formation|t6A biosynthetic process|threonylcarbamoyladenosine biosynthesis|threonylcarbamoyladenosine synthesis hjd 2014-09-19T10:15:27Z GO:0070526 biological_process owl:Class
GO:0047516 biolink:NamedThing 1,3-propanediol dehydrogenase activity Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+. got7fsn_ti 1,3-propanediol oxidoreductase activity|1,3-PD:NAD+ oxidoreductase activity|1,3-propanediol:NAD+ oxidoreductase activity|propane-1,3-diol:NAD+ 1-oxidoreductase activity|3-hydroxypropionaldehyde reductase activity RHEA:23188|EC:1.1.1.202|MetaCyc:13-PROPANEDIOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0110135 biolink:NamedThing Norrin signaling pathway The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state. got7fsn_ti kmv 2019-01-18T19:07:18Z biological_process owl:Class
GO:1905114 biolink:NamedThing cell surface receptor signaling pathway involved in cell-cell signaling Any cell surface receptor signaling pathway that is involved in cell-cell signaling. got7fsn_ti cell surface receptor linked signalling pathway involved in cell-cell signalling|cell surface receptor linked signaling pathway involved in cell-cell signaling|cell surface receptor linked signal transduction involved in cell-cell signaling|cell surface receptor linked signalling pathway involved in cell-cell signaling|cell surface receptor linked signaling pathway involved in cell-cell signalling|cell surface receptor linked signal transduction involved in cell-cell signalling|cell surface receptor signaling pathway involved in cell-cell signalling dos 2016-04-06T16:59:57Z biological_process owl:Class
GO:0008360 biolink:NamedThing regulation of cell shape Any process that modulates the surface configuration of a cell. got7fsn_ti GO:0045788|GO:0045789 biological_process owl:Class
GO:0022604 biolink:NamedThing regulation of cell morphogenesis Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized. got7fsn_ti positive regulation of cell shape and cell size|regulation of cell shape and cell size|negative regulation of cell shape and cell size biological_process owl:Class
GO:0044737 biolink:NamedThing modulation of acid-sensing ion channel in other organism Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism. got7fsn_ti regulation of acid-sensing ion channel in other organism|regulation of ASIC channel in other organism jl 2012-11-06T16:51:24Z biological_process owl:Class
GO:0004038 biolink:NamedThing allantoinase activity Catalysis of the reaction: allantoin + H2O = allantoate. got7fsn_ti (S)-allantoin amidohydrolase activity MetaCyc:ALLANTOINASE-RXN|RHEA:17029|EC:3.5.2.5 molecular_function owl:Class
GO:0018814 biolink:NamedThing phenylacetaldoxime dehydratase activity Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile. got7fsn_ti (Z)-phenylacetaldehyde-oxime hydro-lyase activity|OxdB|(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity|PAOx dehydratase activity|arylacetaldoxime dehydratase activity MetaCyc:4.99.1.7-RXN|KEGG_REACTION:R07638|EC:4.99.1.7|UM-BBD_reactionID:r0697|RHEA:20069 molecular_function owl:Class
GO:0071828 biolink:NamedThing apolipoprotein E recycling The process in which chylomicron remnant-associated apolipoprotein E is internalized by endocytosis, localized to recycling endosomes and then secreted in association with a high-density lipoprotein particle. got7fsn_ti APOE recycling mah 2010-09-08T11:05:15Z biological_process owl:Class
GO:1990744 biolink:NamedThing primary miRNA methylation The posttranscriptional addition of methyl groups to specific residues in an primary miRNA molecule. got7fsn_ti sp 2015-05-15T05:18:47Z biological_process owl:Class
GO:0036136 biolink:NamedThing kynurenine-oxaloacetate transaminase activity Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate. got7fsn_ti L-kynurenine-oxaloacetate transaminase activity bf 2012-03-06T02:14:11Z molecular_function owl:Class
GO:0018214 biolink:NamedThing protein carboxylation The addition of a carboxy group to a protein amino acid. got7fsn_ti protein amino acid carboxylation biological_process owl:Class
GO:1990451 biolink:NamedThing cellular stress response to acidic pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution. got7fsn_ti cellular stress response to acidity An example of this is NOX1 in human (Q9Y5S8) in PMID:10615049. jl 2014-08-06T14:06:58Z biological_process owl:Class
GO:0018529 biolink:NamedThing nitrilotriacetate monooxygenase activity Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate. got7fsn_ti UM-BBD_reactionID:r0587|EC:1.14.14.10 molecular_function owl:Class
GO:2000117 biolink:NamedThing negative regulation of cysteine-type endopeptidase activity Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity. got7fsn_ti negative regulation of thiol endopeptidase activity|negative regulation of lysosomal cysteine-type endopeptidase jl 2010-09-23T10:24:35Z biological_process owl:Class
GO:0015311 biolink:NamedThing monoamine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out). got7fsn_ti monoamine:hydrogen antiporter activity molecular_function owl:Class
GO:0060027 biolink:NamedThing convergent extension involved in gastrulation The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis usually resulting in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. got7fsn_ti biological_process owl:Class
GO:0031257 biolink:NamedThing cell trailing edge membrane The portion of the plasma membrane surrounding the trailing edge of a motile cell. got7fsn_ti trailing edge membrane cellular_component owl:Class
GO:0050757 biolink:NamedThing thymidylate synthase biosynthetic process The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. got7fsn_ti thymidylate synthase formation|thymidylate synthase anabolism|thymidylate synthase biosynthesis|thymidylate synthase synthesis biological_process owl:Class
GO:0070037 biolink:NamedThing rRNA (pseudouridine) methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a pseudouridine residue in an rRNA molecule. got7fsn_ti Reactome:R-HSA-6790906 molecular_function owl:Class
GO:0007099 biolink:NamedThing centriole replication The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0. got7fsn_ti ciliary basal body duplication|centriole duplication|microtubule basal body duplication GO:0032054 biological_process owl:Class
GO:0102926 biolink:NamedThing solanidine glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + solanidine = H+ + gamma-chaconine + UDP. got7fsn_ti MetaCyc:RXN-8882 molecular_function owl:Class
GO:0044323 biolink:NamedThing retinoic acid-responsive element binding Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. got7fsn_ti RARE binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. jl 2010-08-03T03:19:05Z molecular_function owl:Class
GO:0061923 biolink:NamedThing (2S,3R,6S,9S)-(-)-protoillud-7-ene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + (2S,3R,6S,9S)-(-)-protoillud-7-ene. got7fsn_ti protoillud-7-ene synthase activity dph 2017-08-02T15:48:21Z molecular_function owl:Class
GO:0047847 biolink:NamedThing deoxyuridine phosphorylase activity Catalysis of the reaction: deoxyuridine + phosphate = uracil + deoxy-D-ribose 1-phosphate. got7fsn_ti deoxyuridine:phosphate deoxy-alpha-D-ribosyltransferase activity|deoxyuridine:phosphate deoxy-D-ribosyltransferase activity|2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase activity MetaCyc:DEOXYURIDINE-PHOSPHORYLASE-RXN|EC:2.4.2.23|RHEA:22824 molecular_function owl:Class
GO:0045213 biolink:NamedThing neurotransmitter receptor metabolic process The chemical reactions and pathways involving neurotransmitter receptors. got7fsn_ti neurotransmitter receptor metabolism biological_process owl:Class
GO:0021992 biolink:NamedThing cell proliferation involved in neural plate elongation The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue. got7fsn_ti biological_process owl:Class
GO:0031919 biolink:NamedThing vitamin B6 transport The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0055100 biolink:NamedThing adiponectin binding Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism. got7fsn_ti molecular_function owl:Class
GO:0061377 biolink:NamedThing mammary gland lobule development The progression of the mammary gland lobule over time, from its formation to the mature structure. A mammary gland lobule is a small rounded projection of the mammary gland. got7fsn_ti dph 2010-11-09T09:36:29Z biological_process owl:Class
GO:1901678 biolink:NamedThing iron coordination entity transport The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti pr 2012-11-22T15:43:15Z biological_process owl:Class
GO:0003168 biolink:NamedThing Purkinje myocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle. got7fsn_ti cardiac Purkinje fiber cell differentiation dph 2009-10-01T02:49:54Z biological_process owl:Class
GO:0002571 biolink:NamedThing somatic diversification of T cell receptor genes by N region addition The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene. got7fsn_ti somatic diversification of TCR genes by N region addition biological_process owl:Class
GO:0009557 biolink:NamedThing antipodal cell differentiation The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell. got7fsn_ti biological_process owl:Class
GO:1990068 biolink:NamedThing seed dehydration The seed development process whose outcome is the drying of a maturing seed. got7fsn_ti tb 2013-03-27T21:16:03Z biological_process owl:Class
GO:0047133 biolink:NamedThing dimethylamine dehydrogenase activity Catalysis of the reaction: electron-transferring flavoprotein + H2O + dimethylamine = reduced electron-transferring flavoprotein + formaldehyde + methylamine. got7fsn_ti DMADh activity|dimethylamine:electron-transferring flavoprotein oxidoreductase activity EC:1.5.8.1|UM-BBD_reactionID:r1380|RHEA:10204|MetaCyc:1.5.8.1-RXN molecular_function owl:Class
GO:0046665 biolink:NamedThing amnioserosa maintenance Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. got7fsn_ti biological_process owl:Class
GO:0004377 biolink:NamedThing GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage. got7fsn_ti guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity|GDP-mannose-oligosaccharide-lipid mannosyltransferase activity|GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity|GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity|oligosaccharide-lipid mannosyltransferase activity|glycolipid 2-alpha-mannosyltransferase activity EC:2.4.1.131|RHEA:29523|MetaCyc:2.4.1.131-RXN molecular_function owl:Class
GO:0047135 biolink:NamedThing bis-gamma-glutamylcystine reductase activity Catalysis of the reaction: 2 L-gamma-glutamyl-L-cysteine + NADP(+) = bis-gamma-glutamylcystine + H(+) + NADPH. got7fsn_ti Bis-gamma-glutamylcystine reductase (NADPH)|bis-gamma-glutamylcystine reductase (NADPH) activity|NADPH:bis-gamma-glutamylcysteine oxidoreductase activity|gamma-glutamylcysteine:NADP+ oxidoreductase activity|NADPH2:bis-gamma-glutamylcysteine oxidoreductase activity|bis-g-glutamylcystine reductase (NADPH) activity RHEA:11980|KEGG_REACTION:R02742|EC:1.8.1.13|MetaCyc:1.6.4.9-RXN molecular_function owl:Class
GO:0010296 biolink:NamedThing prenylcysteine methylesterase activity Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+. got7fsn_ti MetaCyc:RXN-8409|RHEA:48520 molecular_function owl:Class
GO:0036502 biolink:NamedThing Derlin-1-VIMP complex A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome. got7fsn_ti Derlin-1/VIMP complex bf 2015-05-14T11:40:45Z cellular_component owl:Class
GO:0043968 biolink:NamedThing histone H2A acetylation The modification of histone H2A by the addition of an acetyl group. got7fsn_ti biological_process owl:Class
GO:0018121 biolink:NamedThing NAD(P)-asparagine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine. got7fsn_ti molecular_function owl:Class
GO:0033761 biolink:NamedThing mugineic-acid 3-dioxygenase activity Catalysis of the reactions: mugineic acid + 2-oxoglutarate + O2 = 3-epihydroxymugineic acid + succinate + CO2. got7fsn_ti mugineic acid,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|IDS2 MetaCyc:RXN-7982|KEGG_REACTION:R07186|RHEA:14509|EC:1.14.11.25 molecular_function owl:Class
GO:0070871 biolink:NamedThing cell wall organization involved in conjugation with cellular fusion A process of cell wall organization that contributes to conjugation with cellular fusion. got7fsn_ti cell wall organisation involved in conjugation with cellular fusion mah 2009-08-20T02:23:19Z biological_process owl:Class
GO:0032349 biolink:NamedThing positive regulation of aldosterone biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone. got7fsn_ti up regulation of aldosterone biosynthetic process|activation of aldosterone biosynthetic process|up-regulation of aldosterone biosynthetic process|stimulation of aldosterone biosynthetic process|upregulation of aldosterone biosynthetic process biological_process owl:Class
GO:0047958 biolink:NamedThing glycine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate. got7fsn_ti glycine transaminase activity|L-glutamate:glyoxylate aminotransferase activity|glyoxylate-glutamic transaminase activity|glycine aminotransferase activity|glutamate-glyoxylate transaminase activity|glyoxylate-glutamate aminotransferase activity|glutamic-glyoxylic transaminase activity RHEA:14089|MetaCyc:GLYCINE-AMINOTRANSFERASE-RXN|EC:2.6.1.4 molecular_function owl:Class
GO:0016689 biolink:NamedThing manganese peroxidase activity Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O. got7fsn_ti Mn-dependent peroxidase activity|Mn-dependent (NADH-oxidizing) peroxidase activity|Mn(II):hydrogen-peroxide oxidoreductase activity|peroxidase-M2 RHEA:22776|EC:1.11.1.13|MetaCyc:MANGANESE-PEROXIDASE-RXN molecular_function owl:Class
GO:0036019 biolink:NamedThing endolysosome An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place. got7fsn_ti bf 2011-10-13T02:35:13Z cellular_component owl:Class
GO:1990423 biolink:NamedThing RZZ complex A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints. got7fsn_ti Rod-Zwilch-Zw10 complex Example annotations for this term would be D. melanogaster mit(1)15 (Q9W4X9), rod and zwilch (Q9VA00). jl 2014-07-23T11:16:42Z cellular_component owl:Class
GO:0050025 biolink:NamedThing L-glutamate oxidase activity Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2. got7fsn_ti glutamate (acceptor) dehydrogenase activity|glutamic dehydrogenase (acceptor)|glutamic acid oxidase activity|L-glutamate:oxygen oxidoreductase (deaminating)|glutamate oxidase activity|L-glutamic acid oxidase activity MetaCyc:L-GLUTAMATE-OXIDASE-RXN|RHEA:20728|EC:1.4.3.11 molecular_function owl:Class
GO:0097652 biolink:NamedThing phosphatidylinositol 3-kinase complex, class II A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast. got7fsn_ti class II phosphatidylinositol 3-kinase complex|class II PI3K complex pr 2014-09-16T13:14:17Z cellular_component owl:Class
GO:0034771 biolink:NamedThing histone H4-K20 monomethylation The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone. got7fsn_ti histone H4 K20 monomethylation|histone lysine H4 K20 monomethylation biological_process owl:Class
GO:0031761 biolink:NamedThing fMet-Leu-Phe receptor binding Binding to a fMet-Leu-Phe receptor. got7fsn_ti N-formyl peptide receptor binding|fMet-Leu-Phe receptor ligand molecular_function owl:Class
GO:0018446 biolink:NamedThing pinocarveol dehydrogenase activity Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0717 molecular_function owl:Class
GO:0016084 biolink:NamedThing myostimulatory hormone activity The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction. got7fsn_ti molecular_function owl:Class
GO:0030572 biolink:NamedThing phosphatidyltransferase activity Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group. got7fsn_ti molecular_function owl:Class
GO:0032137 biolink:NamedThing guanine/thymine mispair binding Binding to a double-stranded DNA region containing a G/T mispair. got7fsn_ti G/T mispair binding|T/G mispair binding|thymine/guanine mispair binding molecular_function owl:Class
GO:0002172 biolink:NamedThing high-affinity IgM receptor activity Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti high affinity IgM receptor activity hjd 2010-05-06T05:03:26Z molecular_function owl:Class
GO:0001793 biolink:NamedThing IgM receptor activity Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0014810 biolink:NamedThing positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. got7fsn_ti biological_process owl:Class
GO:0014809 biolink:NamedThing regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. got7fsn_ti biological_process owl:Class
GO:0044209 biolink:NamedThing AMP salvage The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis. got7fsn_ti AMP biosynthetic process via salvage pathway|adenosine monophosphate salvage jl 2009-10-22T02:52:11Z biological_process owl:Class
GO:0072732 biolink:NamedThing cellular response to calcium ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions. got7fsn_ti cellular response to calcium starvation mah 2012-07-06T02:42:26Z biological_process owl:Class
GO:0010619 biolink:NamedThing adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). got7fsn_ti activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway|activation of adenylate cyclase activity by glucose involved in G-protein signaling|activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway|glucose-sensing PKA pathway biological_process owl:Class
GO:0102155 biolink:NamedThing S-sulfolactate dehydrogenase activity Catalysis of the reaction: (S)-3-sulfonatolactate + NAD <=> 3-sulfonatopyruvate(2-) + NADH + H+. got7fsn_ti RHEA:28194|MetaCyc:RXN-11689|EC:1.1.1.310 molecular_function owl:Class
GO:0047846 biolink:NamedThing deoxynucleotide 3'-phosphatase activity Catalysis of the reaction: a deoxynucleoside 3'-phosphate + H2O = a deoxynucleoside + phosphate. got7fsn_ti 3'-deoxynucleotidase activity|deoxyribonucleotide 3'-phosphohydrolase activity|3'-deoxyribonucleotidase activity RHEA:10092|EC:3.1.3.34|MetaCyc:DEOXYNUCLEOTIDE-3-PHOSPHATASE-RXN molecular_function owl:Class
GO:0102741 biolink:NamedThing paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity Catalysis of the reaction: 1,7-dimethylxanthine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-7601|EC:2.1.1.160|RHEA:10280 molecular_function owl:Class
GO:0048211 biolink:NamedThing Golgi vesicle docking The initial attachment of a Golgi transport vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the Golgi vesicle and the target membrane. got7fsn_ti Golgi vesicle to membrane docking|dictyosome vesicle docking to target membrane|Golgi-derived vesicle docking|Golgi vesicle docking with target membrane biological_process owl:Class
GO:0140504 biolink:NamedThing microlipophagy Microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion, such as during the transition to stationary phase or in response to nutrient limitation. Microlipophagy is mediated by the formation of sterol-enriched vacuolar microdomains at sites of engulfment. Initiation of microautophagy is defined as the point where liquid-ordered microdomains are formed at sites of engulfment, that requires S. cerevisiae Atg32p and Atg21p, as well as Niemann-Pick type C (NPC) sterol transporter proteins, Ncr1p and Npc2p. This is followed by redistribution of Atg14p from ER exit sites onto liquid-ordered vacuole membrane domains through interaction with stabilized AMP-activated protein kinase (AMPK), and together with Atg6p facilities docking and internalization of lipid droplets (LDs) at sites of invagination. got7fsn_ti lipid droplet autophagy https://github.com/geneontology/go-ontology/issues/19869 pg 2020-08-14T12:53:43Z biological_process owl:Class
GO:0038107 biolink:NamedThing nodal signaling pathway involved in determination of left/right asymmetry A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves. got7fsn_ti nodal signalling pathway involved in determination of left/right asymmetry|regulation of transcription from RNA polymerase II promoter by nodal signaling pathway, involved in determination of left/right symmetry bf 2012-02-29T10:18:59Z biological_process owl:Class
GO:1900094 biolink:NamedThing regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry Any regulation of transcription from RNA polymerase II promoter that is involved in determination of left/right symmetry. got7fsn_ti regulation of global transcription from Pol II promoter of determination of left/right asymmetry|global transcription regulation from Pol II promoter of determination of left/right symmetry|regulation of transcription from Pol II promoter of determination of left/right symmetry|regulation of transcription from Pol II promoter of determination of left/right asymmetry|regulation of transcription from RNA polymerase II promoter of determination of left/right symmetry|regulation of global transcription from Pol II promoter of determination of left/right symmetry|regulation of transcription from RNA polymerase II promoter of determination of left/right asymmetry|regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right symmetry|regulation of transcription from RNA polymerase II promoter, global of determination of left/right symmetry|regulation of transcription from RNA polymerase II promoter, global of determination of left/right asymmetry|regulation of gene-specific transcription from RNA polymerase II promoter of determination of left/right asymmetry|global transcription regulation from Pol II promoter of determination of left/right asymmetry vk 2012-02-14T10:58:20Z biological_process owl:Class
GO:0097377 biolink:NamedThing spinal cord interneuron axon guidance The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord. got7fsn_ti pr 2012-10-01T10:19:42Z biological_process owl:Class
GO:0099548 biolink:NamedThing trans-synaptic signaling by nitric oxide Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide. got7fsn_ti biological_process owl:Class
GO:1990383 biolink:NamedThing cellular response to biotin starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin. got7fsn_ti al 2014-05-21T10:06:58Z biological_process owl:Class
GO:0050040 biolink:NamedThing lactate 2-monooxygenase activity Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O. got7fsn_ti lactic oxygenase activity|L-lactate monooxygenase activity|lactate oxygenase activity|(S)-lactate:oxygen 2-oxidoreductase (decarboxylating)|lactate monooxygenase activity|lactate oxidative decarboxylase activity|L-lactate-2-monooxygenase activity|lactic oxidase activity|lactate oxidase activity EC:1.13.12.4|MetaCyc:LACTATE-2-MONOOXYGENASE-RXN|RHEA:16513|KEGG_REACTION:R00319 molecular_function owl:Class
GO:0061764 biolink:NamedThing late endosome to lysosome transport via multivesicular body sorting pathway The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome. got7fsn_ti dph 2016-04-19T09:29:57Z biological_process owl:Class
GO:0036211 biolink:NamedThing protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). got7fsn_ti protein modification bf 2012-04-26T01:47:12Z biological_process owl:Class
GO:0042026 biolink:NamedThing protein refolding The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. got7fsn_ti heat shock protein activity biological_process owl:Class
GO:0098967 biolink:NamedThing exocytic insertion of neurotransmitter receptor to postsynaptic membrane The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion. got7fsn_ti biological_process owl:Class
GO:0036147 biolink:NamedThing rumination A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again. got7fsn_ti digestive rumination bf 2012-03-13T04:35:19Z biological_process owl:Class
GO:0035911 biolink:NamedThing descending aorta morphogenesis The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:19:24Z biological_process owl:Class
GO:0002259 biolink:NamedThing endothelial cell activation within high endothelial venule involved in immune response A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. got7fsn_ti endothelial cell activation within high endothelial venule during immune response biological_process owl:Class
GO:0002264 biolink:NamedThing endothelial cell activation involved in immune response A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. got7fsn_ti endothelial cell activation during immune response biological_process owl:Class
GO:0010123 biolink:NamedThing acetate catabolic process to butyrate, ethanol, acetone and butanol The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol. got7fsn_ti acetate fermentation to butyrate, ethanol, acetone and butanol MetaCyc:CENTFERM-PWY biological_process owl:Class
GO:0008465 biolink:NamedThing glycerate dehydrogenase activity Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+. got7fsn_ti hydroxypyruvate dehydrogenase activity RHEA:17905|EC:1.1.1.29|MetaCyc:GLYCERATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0008776 biolink:NamedThing acetate kinase activity Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate. got7fsn_ti AckA|AK activity|acetate kinase (phosphorylating) activity|ATP:acetate phosphotransferase activity|acetic kinase activity|acetokinase activity RHEA:11352|EC:2.7.2.1|MetaCyc:ACETATEKIN-RXN molecular_function owl:Class
GO:0006881 biolink:NamedThing extracellular sequestering of iron ion The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system. got7fsn_ti extracellular retention of iron ion|extracellular iron ion sequestration|extracellular sequestration of iron ion|extracellular iron ion retention|extracellular iron ion storage|extracellular iron ion sequestering|extracellular storage of iron ion biological_process owl:Class
GO:0097577 biolink:NamedThing sequestering of iron ion The process of binding or confining iron ions such that they are separated from other components of a biological system. got7fsn_ti retention of iron ion|iron ion retention|storage of iron ion|sequestration of iron ion|iron ion sequestration|iron ion storage|iron ion sequestering pr 2014-02-28T11:10:53Z biological_process owl:Class
GO:0070464 biolink:NamedThing alphav-beta3 integrin-collagen alpha3(VI) complex A protein complex that consists of an alphav-beta3 integrin complex bound to the alpha3 chain of type VI collagen; the integrin binds most strongly to unfolded collagen. got7fsn_ti cellular_component owl:Class
GO:0098511 biolink:NamedThing sensory perception of low humidity The series of events required for an organism to detect low environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti dos 2013-09-25T14:02:02Z biological_process owl:Class
GO:0061529 biolink:NamedThing epinephrine secretion, neurotransmission The regulated release of epinephrine by a cell in which the epinephrine acts as a neurotransmitter. got7fsn_ti adrenaline secretion, neurotransmission dph 2013-06-21T15:47:22Z biological_process owl:Class
GO:0032237 biolink:NamedThing activation of store-operated calcium channel activity A process that initiates the activity of an inactive store-operated calcium channel. got7fsn_ti biological_process owl:Class
GO:1901341 biolink:NamedThing positive regulation of store-operated calcium channel activity Any process that activates or increases the frequency, rate or extent of store-operated calcium channel activity. got7fsn_ti up-regulation of store-operated calcium channel activity|activation of store-operated calcium channel activity|up regulation of store-operated calcium channel activity|upregulation of store-operated calcium channel activity pr 2012-09-03T14:24:38Z biological_process owl:Class
GO:0072716 biolink:NamedThing response to actinomycin D Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus. got7fsn_ti mah 2012-04-26T02:06:40Z biological_process owl:Class
GO:0033417 biolink:NamedThing CUU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CUU codon. got7fsn_ti leucine tRNA|CTT codon-amino acid adaptor activity Note that in the standard genetic code, CTT codes for leucine. molecular_function owl:Class
GO:0042407 biolink:NamedThing cristae formation The assembly of cristae, the inwards folds of the inner mitochondrial membrane. got7fsn_ti biological_process owl:Class
GO:0090686 biolink:NamedThing glycine betaine-activated nonselective monovalent cation channel activity Enables the transmembrane transfer of a monovalent cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts. got7fsn_ti tb 2016-07-20T16:29:01Z molecular_function owl:Class
GO:0052655 biolink:NamedThing L-valine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamatic acid. got7fsn_ti L-valine aminotransferase activity EC:2.6.1.42|MetaCyc:BRANCHED-CHAINAMINOTRANSFERVAL-RXN|RHEA:24813|KEGG_REACTION:R01214 molecular_function owl:Class
GO:0004084 biolink:NamedThing branched-chain-amino-acid transaminase activity Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. got7fsn_ti branched-chain amino acid aminotransferase activity|glutamate-branched-chain amino acid transaminase activity|branched-chain-amino-acid:2-oxoglutarate aminotransferase activity|branched-chain amino acid-glutamate transaminase activity|branched-chain aminotransferase activity|transaminase B activity|L-branched chain amino acid aminotransferase activity Reactome:R-HSA-70724|EC:2.6.1.42|Reactome:R-HSA-508179|Reactome:R-HSA-508189|Reactome:R-HSA-70723 molecular_function owl:Class
GO:0071722 biolink:NamedThing detoxification of arsenic-containing substance Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds. got7fsn_ti detoxification of arsenic mah 2010-03-17T01:35:56Z biological_process owl:Class
GO:0015616 biolink:NamedThing DNA translocase activity Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21612 Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. molecular_function owl:Class
GO:0005595 biolink:NamedThing collagen type XII trimer A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures. got7fsn_ti cellular_component owl:Class
GO:0018526 biolink:NamedThing 2-aminobenzoyl-CoA reductase activity Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA. got7fsn_ti UM-BBD_reactionID:r0342 molecular_function owl:Class
GO:0043798 biolink:NamedThing glycerate 2-kinase activity Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP. got7fsn_ti glycerate kinase|D-glycerate 2-kinase activity EC:2.7.1.165|MetaCyc:GKI-RXN|RHEA:27377 molecular_function owl:Class
GO:0047902 biolink:NamedThing formylaspartate deformylase activity Catalysis of the reaction: N-formyl-L-aspartate + H2O = formate + L-aspartate. got7fsn_ti N-formyl-L-aspartate amidohydrolase activity|formylaspartic formylase (formylase I, formylase II) MetaCyc:FORMYLASPARTATE-DEFORMYLASE-RXN|RHEA:22040|EC:3.5.1.8 molecular_function owl:Class
GO:0047677 biolink:NamedThing arachidonate 8(R)-lipoxygenase activity Catalysis of the reaction: arachidonate + O(2) = (5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. got7fsn_ti arachidonate 8-lipoxygenase activity|arachidonate:oxygen 8-oxidoreductase activity|8(R)-lipoxygenase activity|8-lipoxygenase activity This activity produces the R-enantiomer of HPETE, 8(R)-HPETE. For the reaction producing the S-enantiomer, see GO:0036403. MetaCyc:ARACHIDONATE-8-LIPOXYGENASE-RXN|EC:1.13.11.40|RHEA:14985|KEGG_REACTION:R01594 molecular_function owl:Class
GO:0071432 biolink:NamedThing peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of conjugation with cellular fusion. got7fsn_ti peptide mating pheromone formation involved in conjugation with cellular fusion|alpha-factor maturation|peptide mating pheromone processing involved in conjugation with cellular fusion|a-factor processing (proteolytic)|mating-type peptide pheromone maturation involved in conjugation with cellular fusion mah 2009-12-16T10:46:50Z biological_process owl:Class
GO:0098885 biolink:NamedThing modification of postsynaptic actin cytoskeleton Any process that modifies the structure of a postsynaptic actin cytoskeleton. got7fsn_ti postsynaptic actin cytoskeleton remodelling This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones. biological_process owl:Class
GO:0099010 biolink:NamedThing modification of postsynaptic structure Any process that modifies the structure of a postsynapse. got7fsn_ti synapse remodelling This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones. biological_process owl:Class
GO:0004018 biolink:NamedThing N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. got7fsn_ti succino AMP-lyase activity|6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity|adenylosuccinate lyase activity|adenylosuccinase activity|N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity Reactome:R-HSA-73800|RHEA:16853|EC:4.3.2.2|KEGG_REACTION:R01083|Reactome:R-HSA-73828|MetaCyc:AMPSYN-RXN molecular_function owl:Class
GO:0050411 biolink:NamedThing agaritine gamma-glutamyltransferase activity Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor. got7fsn_ti (gamma-L-glutamyl)-N1-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity|(gamma-L-glutamyl)-1-N-(4-hydroxymethylphenyl)hydrazine:(acceptor) gamma-glutamyltransferase activity|agaritine g-glutamyltransferase activity MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN|EC:2.3.2.9 molecular_function owl:Class
GO:0002403 biolink:NamedThing T cell tolerance induction in mucosal-associated lymphoid tissue Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells. got7fsn_ti T cell tolerance induction in MALT biological_process owl:Class
GO:0003972 biolink:NamedThing RNA ligase (ATP) activity Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). got7fsn_ti polyribonucleotide synthase (ATP) activity|ribonucleic ligase activity|polyribonucleotide ligase activity|poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming) MetaCyc:RNA-LIGASE-ATP-RXN|Reactome:R-HSA-5696816|EC:6.5.1.3 molecular_function owl:Class
GO:0102855 biolink:NamedThing 1-18:1-2-18:2-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti RHEA:46332|EC:1.14.19.22|MetaCyc:RXN-8322 molecular_function owl:Class
GO:0018285 biolink:NamedThing iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide RESID:AA0137 biological_process owl:Class
GO:0046651 biolink:NamedThing lymphocyte proliferation The expansion of a lymphocyte population by cell division. got7fsn_ti biological_process owl:Class
GO:0060200 biolink:NamedThing clathrin-sculpted acetylcholine transport vesicle A clathrin-sculpted lipid bilayer membrane-enclosed vesicle after clathrin release and containing acetylcholine. got7fsn_ti clathrin sculpted acetylcholine transport vesicle|clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle cellular_component owl:Class
GO:0039529 biolink:NamedThing RIG-I signaling pathway Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. got7fsn_ti retinoic acid inducible gene I signaling pathway|DDX58 signaling pathway|RIG-I signalling pathway The apoptosis effect triggered by the RIG-I signaling pathway is inconclusive and may represent an in-vitro phenomenon. Therefore, in GO the term 'RIG-I signaling pathway ; GO:0039529' is positioned under 'regulation of cytokine production' as this is its primary effect. bf 2011-12-20T03:11:06Z biological_process owl:Class
GO:0098620 biolink:NamedThing seryl-selenocysteinyl-tRNA kinase activity Catalysis of the reaction: Ser-tRNA(Sec) + ATP = Sep-tRNA(Sec) + ADP. got7fsn_ti Reactome:R-HSA-2408507 molecular_function owl:Class
GO:0042013 biolink:NamedThing interleukin-19 binding Binding to interleukin-19. got7fsn_ti IL-19 binding molecular_function owl:Class
GO:0060540 biolink:NamedThing diaphragm morphogenesis The process in which the anatomical structures of the diaphragm are generated and organized. got7fsn_ti dph 2009-04-10T08:47:51Z biological_process owl:Class
GO:0070302 biolink:NamedThing regulation of stress-activated protein kinase signaling cascade Any process that modulates the frequency, rate or extent of signaling via a stress-activated protein kinase signaling cascade. got7fsn_ti regulation of stress-activated protein kinase signalling pathway|regulation of stress-activated protein kinase signaling pathway|regulation of SAPK signaling pathway biological_process owl:Class
GO:0070102 biolink:NamedThing interleukin-6-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-6-mediated signaling pathway|interleukin-6-mediated signalling pathway biological_process owl:Class
GO:0033837 biolink:NamedThing anthocyanin 3'-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + an anthocyanin = UDP + an anthocyanin 3'-O-beta-D-glucoside. got7fsn_ti UDP-glucose:anthocyanin 3'-O-glucosyltransferase activity|UDP-glucose:anthocyanin 3'-O-beta-D-glucosyltransferase activity|3'GT MetaCyc:2.4.1.238-RXN|EC:2.4.1.238|RHEA:35627 molecular_function owl:Class
GO:0042466 biolink:NamedThing chemokinesis A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis). got7fsn_ti Wikipedia:Chemokinesis biological_process owl:Class
GO:0003242 biolink:NamedThing cardiac chamber ballooning The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping. got7fsn_ti dph 2009-10-13T11:30:30Z biological_process owl:Class
GO:0072551 biolink:NamedThing diferuloyl mono-(hydroxyferuloyl) spermidine meta-hydroxylase activity Catalysis of the reaction: diferuloyl mono-(hydroxyferuloyl) spermidine + NADPH + O2 = monoferuloyl di-(hydroxyferuloyl) spermidine + NADP+ + H2O. got7fsn_ti mah 2011-01-25T03:04:16Z molecular_function owl:Class
GO:1990302 biolink:NamedThing Bre1-Rad6 ubiquitin ligase complex A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis. got7fsn_ti Bre1-Rad6 complex This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:19531475 (inferred from direct assay). bhm 2014-02-28T16:50:34Z cellular_component owl:Class
GO:0032184 biolink:NamedThing SUMO polymer binding Binding to a polymer of the small ubiquitin-like protein SUMO. got7fsn_ti Smt3 polymer binding molecular_function owl:Class
GO:0032183 biolink:NamedThing SUMO binding Binding to the small ubiquitin-like protein SUMO. got7fsn_ti Smt3 monomer binding|Smt3 binding molecular_function owl:Class
GO:0031093 biolink:NamedThing platelet alpha granule lumen The volume enclosed by the membrane of the platelet alpha granule. got7fsn_ti platelet alpha-granule lumen cellular_component owl:Class
GO:0106259 biolink:NamedThing cell-to-cell migration in host The directional movement of a symbiont from one host cell to another. got7fsn_ti hjd 2020-05-01T14:09:35Z biological_process owl:Class
GO:0052732 biolink:NamedThing phosphoethanolamine phosphatase activity Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate. got7fsn_ti PHOSPHO1|phosphoethanolamine phosphohydrolase activity|3X11A ai 2011-08-16T04:09:19Z EC:3.1.3.75|Reactome:R-HSA-1483096|MetaCyc:RXN-7948|RHEA:16089|KEGG_REACTION:R06870 molecular_function owl:Class
GO:0035501 biolink:NamedThing MH1 domain binding Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors. got7fsn_ti MAD homology 1 domain binding bf 2010-04-29T03:17:27Z molecular_function owl:Class
GO:1990031 biolink:NamedThing pinceau fiber Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment. got7fsn_ti pr 2013-02-07T12:56:50Z NIF_Subcellular:sao109906988 cellular_component owl:Class
GO:0050792 biolink:NamedThing regulation of viral process Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts. got7fsn_ti regulation of viral reproduction|regulation of viral process biological_process owl:Class
GO:0050184 biolink:NamedThing phosphatidylcholine desaturase activity Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH. got7fsn_ti linoleate synthase activity|oleoyl-CoA desaturase activity|1-acyl-2-oleoyl-sn-glycero-3-phosphocholine:NAD+ delta12-oxidoreductase activity|oleoylphosphatidylcholine desaturase activity|acyl-lipid omega-6 desaturase (cytochrome b5)|oleate desaturase activity KEGG_REACTION:R03475|EC:1.14.19.22|RHEA:12564|MetaCyc:PHOSPHATIDYLCHOLINE-DESATURASE-RXN molecular_function owl:Class
GO:0050096 biolink:NamedThing methylaspartate ammonia-lyase activity Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH(4)(+). got7fsn_ti beta-methylaspartase activity|3-methylaspartase activity|L-threo-3-methylaspartate ammonia-lyase activity|L-threo-3-methylaspartate ammonia-lyase (mesaconate-forming) KEGG_REACTION:R03696|MetaCyc:METHYLASPARTATE-AMMONIA-LYASE-RXN|RHEA:12829|EC:4.3.1.2 molecular_function owl:Class
GO:0043429 biolink:NamedThing 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. got7fsn_ti 2-nonaprenyl-6-methoxy-1,4-benzoquinone methylase activity Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. molecular_function owl:Class
GO:0008949 biolink:NamedThing oxalyl-CoA decarboxylase activity Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA. got7fsn_ti oxalyl coenzyme A decarboxylase activity|oxalyl-CoA carboxy-lyase (formyl-CoA-forming)|oxalyl-CoA carboxy-lyase activity KEGG_REACTION:R01908|EC:4.1.1.8|MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN|RHEA:19333 molecular_function owl:Class
GO:0034831 biolink:NamedThing (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1176 molecular_function owl:Class
GO:0046716 biolink:NamedThing muscle cell cellular homeostasis The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. got7fsn_ti muscle homeostasis|muscle fiber maintenance biological_process owl:Class
GO:0044191 biolink:NamedThing host cell mitochondrial membrane Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope. got7fsn_ti jl 2009-10-15T04:14:35Z cellular_component owl:Class
GO:0071215 biolink:NamedThing cellular response to abscisic acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. got7fsn_ti mah 2009-12-03T01:04:18Z biological_process owl:Class
GO:0009737 biolink:NamedThing response to abscisic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus. got7fsn_ti response to abscisic acid stimulus biological_process owl:Class
GO:0102161 biolink:NamedThing copal-8-ol diphosphate synthase activity Catalysis of the reaction: copal-8-ol diphosphate <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + H2O. got7fsn_ti EC:4.2.1.133|MetaCyc:RXN-11772|RHEA:32703 molecular_function owl:Class
GO:1990508 biolink:NamedThing CKM complex Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8. got7fsn_ti SRB8/9/10/11 complex|CDK8 kinase module|SRB8-SRB11 complex An example of this is SSN2 in Saccharomyces cerevisiae (P38931) in PMID:12200444 (inferred from physical interaction). bhm 2014-10-02T10:05:58Z cellular_component owl:Class
GO:0035383 biolink:NamedThing thioester metabolic process The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. got7fsn_ti thioester metabolism bf 2010-03-18T01:48:12Z biological_process owl:Class
GO:0009730 biolink:NamedThing detection of carbohydrate stimulus The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of carbohydrate stimulus biological_process owl:Class
GO:0035299 biolink:NamedThing inositol pentakisphosphate 2-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+). got7fsn_ti inositol 1,3,4,5,6-pentakisphosphate 2-kinase activity|inositol-pentakisphosphate 2-kinase activity|inositol hexakisphosphate synthase|Ipk1p|inositol polyphosphate kinase activity|Gsl1p|ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase activity|Ins(1,3,4,5,6)P5 2-kinase activity|IP5 2-kinase activity Reactome:R-HSA-1855176|RHEA:20313|MetaCyc:RXN-7163|Reactome:R-HSA-1855179|KEGG_REACTION:R05202|EC:2.7.1.158 molecular_function owl:Class
GO:0051108 biolink:NamedThing carnitine-CoA ligase activity Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA. got7fsn_ti carnitine synthetase activity|crotonobetaine/carnitine-CoA ligase activity RHEA:30543|MetaCyc:DCARNCOALIG-RXN molecular_function owl:Class
GO:0004738 biolink:NamedThing pyruvate dehydrogenase activity Catalysis of the oxidative decarboxylation of pyruvate. got7fsn_ti pyruvic acid dehydrogenase activity|pyruvic dehydrogenase activity Reactome:R-HSA-71397|MetaCyc:PYRUVOXID-RXN|MetaCyc:RXN0-1134 molecular_function owl:Class
GO:0003941 biolink:NamedThing L-serine ammonia-lyase activity Catalysis of the reaction: L-serine = pyruvate + NH3. got7fsn_ti L-serine dehydratase activity|L-serine ammonia-lyase (pyruvate-forming) activity|L-hydroxyaminoacid dehydratase activity|L-serine dehydration activity|serine deaminase activity|L-serine deaminase activity|L-serine hydro-lyase (deaminating) activity Note that this function was formerly EC:4.3.1.13. MetaCyc:4.3.1.17-RXN|RHEA:19169|EC:4.3.1.17 molecular_function owl:Class
GO:0035657 biolink:NamedThing eRF1 methyltransferase complex A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p. got7fsn_ti eRF1 MTase complex bf 2011-01-28T11:29:40Z cellular_component owl:Class
GO:0035552 biolink:NamedThing oxidative single-stranded DNA demethylation Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. got7fsn_ti oxidative ssDNA demethylation bf 2010-05-14T11:03:55Z biological_process owl:Class
GO:0048225 biolink:NamedThing suberin network An extracellular matrix part that consists of fatty acid-derived polymers, including both aromatic and aliphatic components. The suberin network is found in specialized plant cell walls, where it is laid down between the primary wall and plasma membrane, forms protective and wound-healing layers, and provides a water-impermeable diffusion barrier. got7fsn_ti cellular_component owl:Class
GO:0034866 biolink:NamedThing 2,4,4-trimethylpentanoyl-CoA dehydrogenase activity Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1276 molecular_function owl:Class
GO:0044316 biolink:NamedThing cone cell pedicle A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL). got7fsn_ti cone pedicle jl 2010-07-14T01:30:02Z cellular_component owl:Class
GO:0052608 biolink:NamedThing echinenone 3-hydroxylase activity Catalysis of the reaction: echinenone + a reduced electron acceptor + oxygen = 3-hydroxyechinenone + an oxidized electron acceptor + H2O. got7fsn_ti beta-carotene hydroxylase activity|carotene beta-ring hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity MetaCyc:RXN-8214 molecular_function owl:Class
GO:0034221 biolink:NamedThing fungal-type cell wall chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of fungal cells. got7fsn_ti fungal-type cell wall chitin formation|fungal-type cell wall chitin biosynthesis|fungal-type cell wall chitin synthesis|fungal-type cell wall chitin anabolism biological_process owl:Class
GO:0033995 biolink:NamedThing anhydrosialidase activity Catalysis of the reaction: an N-acetylneuraminate glycoside = 2,7-anhydro-alpha-N-acetylneuraminate + an alpha-sialyl group. This reaction is the elimination of alpha-sialyl groups in N-acetylneuraminic acid glycosides, releasing 2,7-anhydro-alpha-N-acetylneuraminate. got7fsn_ti anhydroneuraminidase activity|glycoconjugate sialyl-lyase (2,7-cyclizing) activity|sialglycoconjugate N-acylneuraminylhydrolase (2,7-cyclizing) activity|sialidase L activity EC:4.2.2.15|MetaCyc:4.2.2.15-RXN molecular_function owl:Class
GO:0060182 biolink:NamedThing apelin receptor activity Combining with the peptide apelin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0046415 biolink:NamedThing urate metabolic process The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. got7fsn_ti urate metabolism biological_process owl:Class
GO:0035966 biolink:NamedThing response to topologically incorrect protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. got7fsn_ti response to misfolded or unfolded protein bf 2011-08-03T11:43:12Z biological_process owl:Class
GO:0050493 biolink:NamedThing GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GPI anchor anabolism via N-threonyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-threonyl-glycosylphosphatidylinositolethanolamine|GPI anchor synthesis via N-threonyl-glycosylphosphatidylinositolethanolamine RESID:AA0164 biological_process owl:Class
GO:0031233 biolink:NamedThing intrinsic component of external side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. got7fsn_ti intrinsic to external leaflet of plasma membrane|intrinsic to external side of plasma membrane cellular_component owl:Class
GO:0031226 biolink:NamedThing intrinsic component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to plasma membrane cellular_component owl:Class
GO:0016633 biolink:NamedThing galactonolactone dehydrogenase activity Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c. got7fsn_ti L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity|L-galactono-1,4-lactone dehydrogenase activity|GLDase activity|L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity|L-galactono-gamma-lactone dehydrogenase activity|GLDHase activity|L-galactonolactone dehydrogenase activity EC:1.3.2.3|MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN|RHEA:32367 molecular_function owl:Class
GO:0030107 biolink:NamedThing HLA-A specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte. got7fsn_ti molecular_function owl:Class
GO:0061501 biolink:NamedThing 2',3'-cyclic GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5') (cyclic 2',3' GAMP). got7fsn_ti cyclic 2',3' GAMP synthase activity|cyclic-GMP-AMP synthase activity|2',3' cyclic-GMP-AMP synthase activity|2',3' cyclic GMP-AMP synthase activity https://github.com/geneontology/go-ontology/issues/21980 dph 2013-01-04T07:17:57Z EC:2.7.7.86|Reactome:R-HSA-3244614|RHEA:42064 molecular_function owl:Class
GO:0150089 biolink:NamedThing multiple spine synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and one or more dendritic spines. got7fsn_ti multi-synaptic organization|multisynapse organisation|multisynaptic organisation|multisynaptic organization|multi-synapse organisation|multi-synaptic organisation|multi-synapse organization|multiple spine synapse organisation|multisynapse organization bc 2018-08-08T14:54:50Z biological_process owl:Class
GO:0044853 biolink:NamedThing plasma membrane raft A membrane raft that is part of the plasma membrane. got7fsn_ti jl 2014-07-23T15:55:23Z cellular_component owl:Class
GO:0017056 biolink:NamedThing structural constituent of nuclear pore The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules. got7fsn_ti nucleocytoplasmic transporter activity|nuclear pore activity Note that this term is meant to be used for nuclear pore proteins. For importins and exportins, consider 'nuclear import signal receptor activity' or 'nuclear export signal receptor activity', respectively. tb 2015-06-29T08:59:16Z GO:0005487 Reactome:R-HSA-1176059|Reactome:R-HSA-6783483|Reactome:R-HSA-5252041|Reactome:R-HSA-5661474|Reactome:R-HSA-170796|Reactome:R-HSA-5578744|Reactome:R-HSA-192627|Reactome:R-HSA-192925 molecular_function owl:Class
GO:0036031 biolink:NamedThing recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript. got7fsn_ti capping enzyme targeting to RNA polymerase II|recruitment of guanylyltransferase to RNA polymerase II holoenzyme complex bf 2011-10-24T10:56:46Z biological_process owl:Class
GO:0017083 biolink:NamedThing 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R. got7fsn_ti GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity|lewis-negative alpha-3-fucosyltransferase activity|galactoside 3-L-fucosyltransferase activity|guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity|GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity|GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity|Lewis-negative alpha-3-fucosyltransferase activity|guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity|plasma alpha-3-fucosyltransferase activity|galactoside 3-fucosyltransferase activity RHEA:14257|EC:2.4.1.152|MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0019486 biolink:NamedThing beta-alanine catabolic process to mevalonate semialdehyde, by transamination The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination. got7fsn_ti beta-alanine breakdown to mevalonate semialdehyde, by transamination|beta-alanine degradation to mevalonate semialdehyde, by transamination MetaCyc:BETA-ALA-DEGRADATION-I-PWY biological_process owl:Class
GO:0019484 biolink:NamedThing beta-alanine catabolic process The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins. got7fsn_ti beta-alanine degradation|beta-alanine catabolism|beta-alanine breakdown biological_process owl:Class
GO:0003153 biolink:NamedThing closure of embryonic heart tube Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold. got7fsn_ti tb 2009-09-23T10:14:54Z biological_process owl:Class
GO:0036400 biolink:NamedThing short neuropeptide F receptor activity Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide. got7fsn_ti sNPF receptor activity Despite their naming, neuropeptide F (NPF) and short neuropeptide F (sNPF) are not closely related. bf 2013-07-18T14:46:40Z molecular_function owl:Class
GO:0032263 biolink:NamedThing GMP salvage Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0006177 biolink:NamedThing GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. got7fsn_ti GMP biosynthesis|GMP anabolism|GMP formation|GMP synthesis biological_process owl:Class
GO:0008670 biolink:NamedThing 2,4-dienoyl-CoA reductase (NADPH) activity Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+. got7fsn_ti 4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|4-enoyl-CoA reductase activity|4-enoyl-CoA reductase (NADPH2)|4-enoyl-CoA reductase (NADPH) activity|trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity EC:1.3.1.34|RHEA:12136|MetaCyc:DIENOYLCOAREDUCT-RXN molecular_function owl:Class
GO:0010862 biolink:NamedThing positive regulation of pathway-restricted SMAD protein phosphorylation Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. got7fsn_ti biological_process owl:Class
GO:0090100 biolink:NamedThing positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. got7fsn_ti positive regulation of transmembrane receptor protein serine/threonine kinase signalling pathway tb 2009-11-13T10:55:53Z biological_process owl:Class
GO:0042209 biolink:NamedThing orcinol catabolic process The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants. got7fsn_ti orcin catabolic process|orcin catabolism|orcinol catabolism|orcinol breakdown|orcinol degradation UM-BBD_pathwayID:orc biological_process owl:Class
GO:0021708 biolink:NamedThing Lugaro cell differentiation The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0071972 biolink:NamedThing peptidoglycan L,D-transpeptidase activity Catalysis of the reaction: 2 a peptidoglycan dimer (tetrapeptide) + 3 H2O = a peptidoglycan tetramer with L,D cross-links (L-Lys-D-Asn-L-Lys) + di-trans,poly-cis-undecaprenyl diphosphate + 4 D-alanine. got7fsn_ti mah 2010-10-18T04:36:19Z MetaCyc:RXN-11349 molecular_function owl:Class
GO:0035399 biolink:NamedThing helper T cell enhancement of B cell mediated immune response Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell. got7fsn_ti helper T cell enhancement of B cell mediated immunity|provision of T cell help to B cell bf 2010-03-23T10:41:46Z biological_process owl:Class
GO:0002714 biolink:NamedThing positive regulation of B cell mediated immunity Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. got7fsn_ti activation of B cell mediated immunity|positive regulation of B-cell mediated immunity|up regulation of B cell mediated immunity|positive regulation of B-lymphocyte mediated immunity|positive regulation of B lymphocyte mediated immunity|up-regulation of B cell mediated immunity|upregulation of B cell mediated immunity|stimulation of B cell mediated immunity biological_process owl:Class
GO:0009743 biolink:NamedThing response to carbohydrate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. got7fsn_ti response to carbohydrate stimulus biological_process owl:Class
GO:0060272 biolink:NamedThing embryonic skeletal joint morphogenesis The process in which the anatomical structures of skeletal joints are generated and organized during the embryonic phase. A skeletal joint is the connecting structure between the bones of the skeleton. got7fsn_ti biological_process owl:Class
GO:0035664 biolink:NamedThing TIRAP-dependent toll-like receptor signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response. got7fsn_ti MAL-dependent toll-like receptor signaling pathway|TIRAP-dependent toll-like receptor signalling pathway|TIRAP-dependent TLR signaling pathway|MyD88 adapter-like dependent toll-like receptor signaling pathway bf 2011-02-01T02:31:37Z biological_process owl:Class
GO:0038098 biolink:NamedThing sequestering of BMP from receptor via BMP binding Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor. got7fsn_ti extracellular sequestering of BMP|extracellular sequestering of bone morphogenetic protein bf 2012-02-22T11:28:54Z biological_process owl:Class
GO:0047201 biolink:NamedThing beta-glucogallin O-galloyltransferase activity Catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose. got7fsn_ti 1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity KEGG_REACTION:R00049|MetaCyc:2.3.1.90-RXN|EC:2.3.1.90|RHEA:11416 molecular_function owl:Class
GO:0046969 biolink:NamedThing NAD-dependent histone deacetylase activity (H3-K9 specific) Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein. got7fsn_ti Reactome:R-HSA-9604829 molecular_function owl:Class
GO:0000083 biolink:NamedThing regulation of transcription involved in G1/S transition of mitotic cell cycle Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle. got7fsn_ti biological_process owl:Class
GO:0002276 biolink:NamedThing basophil activation involved in immune response A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response. got7fsn_ti basophil activation during immune response biological_process owl:Class
GO:0034954 biolink:NamedThing diphenyl ether 2,3-dioxygenase activity Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether. got7fsn_ti UM-BBD_reactionID:r1450|EC:1.14.12.- molecular_function owl:Class
GO:0090153 biolink:NamedThing regulation of sphingolipid biosynthetic process Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). got7fsn_ti tb 2009-12-08T03:25:49Z biological_process owl:Class
GO:0036138 biolink:NamedThing peptidyl-histidine hydroxylation The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine. got7fsn_ti bf 2012-03-07T09:25:25Z biological_process owl:Class
GO:0003050 biolink:NamedThing regulation of systemic arterial blood pressure by atrial natriuretic peptide The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide. got7fsn_ti blood pressure regulation by ANP|blood pressure regulation by atrial natriuretic peptide biological_process owl:Class
GO:0015066 biolink:NamedThing alpha-amylase inhibitor activity Binds to and stops, prevents or reduces the activity of alpha-amylase. got7fsn_ti molecular_function owl:Class
GO:0050598 biolink:NamedThing taxane 13-alpha-hydroxylase activity Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol. got7fsn_ti taxane 13alpha-hydroxylase activity|taxa-4(20),11-dien-5alpha-ol,NADPH:oxygen oxidoreductase (13alpha-hydroxylating)|taxane 13a-hydroxylase activity EC:1.14.14.106|KEGG_REACTION:R06308|MetaCyc:1.14.13.77-RXN|RHEA:18949 molecular_function owl:Class
GO:0000701 biolink:NamedThing purine-specific mismatch base pair DNA N-glycosylase activity Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. got7fsn_ti A/G-specific adenine DNA glycosylase activity EC:3.2.2.31 molecular_function owl:Class
GO:0043708 biolink:NamedThing cell adhesion involved in biofilm formation The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm. got7fsn_ti cell adhesion during biofilm formation biological_process owl:Class
GO:0008210 biolink:NamedThing estrogen metabolic process The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. got7fsn_ti oestrogen metabolic process|oestrogen metabolism|estrogen metabolism biological_process owl:Class
GO:0047483 biolink:NamedThing imidazoleacetate-phosphoribosyldiphosphate ligase activity Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O + imidazol-4-ylacetate = 1-(5-phosphoribosyl)imidazol-4-ylacetate + ADP + diphosphate + 2 H(+) + phosphate. got7fsn_ti 5-phosphoribosylimidazoleacetate synthetase activity|imidazoleacetate:5-phosphoribosyl-diphosphate ligase (ADP- and diphosphate-forming) MetaCyc:6.3.4.8-RXN|KEGG_REACTION:R04068|RHEA:16485|EC:6.3.4.8 molecular_function owl:Class
GO:0102460 biolink:NamedThing kaempferol 3-gentiobioside 7-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol-3-gentiobioside + UDP-L-rhamnose = H+ + kaempferol-3-O-gentiobioside-7-O-rhamnoside + UDP. got7fsn_ti MetaCyc:RXN-14008 molecular_function owl:Class
GO:0047786 biolink:NamedThing cortisone alpha-reductase activity Catalysis of the reaction: 4,5alpha-dihydrocortisone + NADP(+) = cortisone + H(+) + NADPH. got7fsn_ti microsomal steroid reductase (5alpha)|4,5alpha-dihydrocortisone:NADP+ delta4-oxidoreductase activity|delta4-3-oxosteroid-5alpha-reductase|delta4-3-ketosteroid reductase (5alpha)|cortisone a-reductase activity|NADPH:Delta4-3-oxosteroid-5alpha-oxidoreductase activity|delta4-5alpha-reductase activity|cortisone delta4-5alpha-reductase activity KEGG_REACTION:R02892|RHEA:17981|MetaCyc:CORTISONE-ALPHA-REDUCTASE-RXN molecular_function owl:Class
GO:0042712 biolink:NamedThing paternal behavior Male behaviors associated with the care and rearing offspring. got7fsn_ti paternal behaviour biological_process owl:Class
GO:0023035 biolink:NamedThing CD40 signaling pathway A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CD40 signalling pathway 2010-02-16T09:30:50Z biological_process owl:Class
GO:0044595 biolink:NamedThing decaprenyldihydroxybenzoate methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate. got7fsn_ti jl 2012-04-26T04:52:05Z Reactome:R-HSA-2162193|MetaCyc:RXN-9282|RHEA:44492 molecular_function owl:Class
GO:0102876 biolink:NamedThing psoralen synthase activity Catalysis of the reaction: (+)-marmesin + NADPH + H+ + O2 <=> psoralen + NADP + acetone + 2 H2O. got7fsn_ti RHEA:19281|EC:1.14.14.141|MetaCyc:RXN-8386 molecular_function owl:Class
GO:0042781 biolink:NamedThing 3'-tRNA processing endoribonuclease activity Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule. got7fsn_ti 3 tRNase activity|tRNA 3' endonuclease activity|3' tRNA processing endoribonuclease activity|ribonuclease Z activity|tRNA 3 endonuclease activity|tRNAse Z|3' tRNase activity|RNase Z activity https://github.com/geneontology/go-ontology/issues/21383 MetaCyc:3.1.26.11-RXN|EC:3.1.26.11 molecular_function owl:Class
GO:0010247 biolink:NamedThing detection of phosphate ion The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal. got7fsn_ti phosphate ion detection|phosphate ion perception|phosphate ion sensing biological_process owl:Class
GO:0099045 biolink:NamedThing viral extrusion The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded. got7fsn_ti VZ:3951 biological_process owl:Class
GO:0004354 biolink:NamedThing glutamate dehydrogenase (NADP+) activity Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+. got7fsn_ti dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))|L-glutamic acid dehydrogenase activity|glutamic acid dehydrogenase|NAD(P)-glutamate dehydrogenase activity|L-glutamate dehydrogenase|L-glutamate:NADP+ oxidoreductase (deaminating)|glutamic dehydrogenase activity|NAD(P)H-dependent glutamate dehydrogenase activity MetaCyc:GLUTSYNIII-PWY|EC:1.4.1.4|RHEA:11612|MetaCyc:GLUTDEHYD-RXN molecular_function owl:Class
GO:0004353 biolink:NamedThing glutamate dehydrogenase [NAD(P)+] activity Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+. got7fsn_ti glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)|glutamic dehydrogenase activity|glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)|L-glutamate:NAD(P)+ oxidoreductase (deaminating) Note that this term has a MetaCyc pathway reference as the pathway only has a single step. Reactome:R-HSA-70600|Reactome:R-HSA-70589|EC:1.4.1.3|MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN|MetaCyc:GLUTAMATE-SYN2-PWY molecular_function owl:Class
GO:1990313 biolink:NamedThing type-III cohesin domain binding Binding to a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain. got7fsn_ti tt 2014-03-07T04:58:07Z molecular_function owl:Class
GO:1990763 biolink:NamedThing arrestin family protein binding Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors. got7fsn_ti sl 2015-06-09T23:29:42Z molecular_function owl:Class
GO:0018548 biolink:NamedThing pentaerythritol trinitrate reductase activity Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate. got7fsn_ti xenobiotic reductase activity UM-BBD_reactionID:r0025|EC:1.6.99.1 molecular_function owl:Class
GO:0018501 biolink:NamedThing cis-chlorobenzene dihydrodiol dehydrogenase activity Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol. got7fsn_ti UM-BBD_enzymeID:e0411 molecular_function owl:Class
GO:0072664 biolink:NamedThing maintenance of protein location in peroxisome Any process in which a protein is maintained in a specific location in a peroxisome, and is prevented from moving elsewhere. got7fsn_ti mah 2011-02-14T02:51:51Z biological_process owl:Class
GO:0102841 biolink:NamedThing 1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:1-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8302|EC:1.14.19.23 molecular_function owl:Class
GO:0097095 biolink:NamedThing frontonasal suture morphogenesis The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized. got7fsn_ti nasofrontal suture morphogenesis pr 2011-07-05T02:57:46Z biological_process owl:Class
GO:0072013 biolink:NamedThing glomus development The progression of the glomus over time from its initial formation until its mature state. The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment. got7fsn_ti pronephric glomus development mah 2010-01-25T02:23:19Z biological_process owl:Class
GO:0019934 biolink:NamedThing cGMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell. got7fsn_ti cGMP-mediated signalling biological_process owl:Class
GO:0019817 biolink:NamedThing vesicle fusion with peroxisome The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome. got7fsn_ti biological_process owl:Class
GO:0039670 biolink:NamedThing viral capsid, turret A turret-like appendage formed at the vertices of an icosahedral capsid. got7fsn_ti bf 2013-09-25T10:08:14Z cellular_component owl:Class
GO:0032635 biolink:NamedThing interleukin-6 production The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-6 secretion|interleukin-6 biosynthetic process|IL-6 production GO:0042226|GO:0072604 biological_process owl:Class
GO:0061979 biolink:NamedThing femoral head articular cartilage development The process whose specific outcome is the progression of femoral head articular cartilage over time, from its formation to the mature structure. got7fsn_ti dph 2018-02-12T20:06:21Z biological_process owl:Class
GO:0061977 biolink:NamedThing hip joint articular cartilage development The process whose specific outcome is the progression of hip joint articular cartilage over time, from its formation to the mature structure. got7fsn_ti dph 2018-02-12T20:03:22Z biological_process owl:Class
GO:0072444 biolink:NamedThing response to mitotic DNA replication checkpoint signaling A process that occurs in response to signals generated as a result of mitotic DNA replication checkpoint signaling. got7fsn_ti response to S-M checkpoint signaling|S-M checkpoint effector process|response to signal involved in mitotic DNA replication checkpoint|response to signal involved in S-M checkpoint|mitotic DNA replication checkpoint effector process mah 2010-12-08T05:13:27Z GO:0072447 biological_process owl:Class
GO:0034981 biolink:NamedThing FHL3-CREB complex A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation. got7fsn_ti cellular_component owl:Class
GO:0050392 biolink:NamedThing vicianin beta-glucosidase activity Catalysis of the reaction: (R)-vicianin + H(2)O = mandelonitrile + vicianose. got7fsn_ti vicianin b-glucosidase activity|(R)-vicianin beta-D-glucohydrolase activity|vicianin hydrolase activity KEGG_REACTION:R03642|RHEA:14041|EC:3.2.1.119|MetaCyc:VICIANIN-BETA-GLUCOSIDASE-RXN molecular_function owl:Class
GO:0030262 biolink:NamedThing apoptotic nuclear changes Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis. got7fsn_ti apoptotic nuclear change biological_process owl:Class
GO:0006921 biolink:NamedThing cellular component disassembly involved in execution phase of apoptosis The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis. got7fsn_ti cellular component disassembly involved in apoptosis|cellular component disassembly involved in apoptotic process|disassembly of cell structures biological_process owl:Class
GO:1990104 biolink:NamedThing DNA bending complex A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction. got7fsn_ti histone-like DNA binding complex bhm 2013-05-20T09:29:06Z cellular_component owl:Class
GO:0070504 biolink:NamedThing selenium-containing prosthetic group biosynthetic process The chemical reactions and pathways resulting in the formation of a prosthetic group that contains selenium, as in the selenium-dependent molybdenum hydroxylases. The selenium atom in the prosthetic group is required for enzymatic function but is labile to a variety of treatments. got7fsn_ti selenium-containing prosthetic group synthesis|selenium-containing prosthetic group formation|selenium-containing prosthetic group anabolism|selenium-containing prosthetic group biosynthesis biological_process owl:Class
GO:0047296 biolink:NamedThing homospermidine synthase activity Catalysis of the reaction: 2 putrescine = NH3 + sym-homospermidine. got7fsn_ti putrescine:putrescine 4-aminobutyltransferase (ammonia-forming) MetaCyc:2.5.1.44-RXN|EC:2.5.1.44|RHEA:18645 molecular_function owl:Class
GO:0051694 biolink:NamedThing pointed-end actin filament capping The binding of a protein or protein complex to the pointed (or minus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits. got7fsn_ti minus-end F-actin capping activity|pointed-end actin capping activity|minus-end actin filament capping activity|pointed-end F-actin capping activity biological_process owl:Class
GO:1904253 biolink:NamedThing positive regulation of bile acid metabolic process Any process that activates or increases the frequency, rate or extent of bile acid metabolic process. got7fsn_ti positive regulation of bile acid metabolism|activation of bile acid metabolism|upregulation of bile acid metabolic process|upregulation of bile acid metabolism|up regulation of bile acid metabolic process|activation of bile acid metabolic process|up-regulation of bile acid metabolic process|up regulation of bile acid metabolism|up-regulation of bile acid metabolism bf 2015-05-20T11:04:40Z biological_process owl:Class
GO:0019540 biolink:NamedThing catechol-containing siderophore biosynthetic process The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol. Catechol is one of the three major chemical groups incorporated into siderophore structures with hydroxamate and a-hydroxycarboxylate, each having a high selectivity for iron(3+). got7fsn_ti https://github.com/geneontology/go-ontology/issues/20975 GO:0031190|GO:0031189 biological_process owl:Class
GO:0016555 biolink:NamedThing uridine to cytidine editing The conversion of a uridine residue to cytosine in an RNA molecule by amination. got7fsn_ti biological_process owl:Class
GO:1990007 biolink:NamedThing membrane stack A configuration of endoplasmic reticulum (ER) found in Purkinje cells in the cerebellum and in axons in the lateral vestibular nucleus, consisting of parallel and interconnecting tubules whose outer surfaces are covered by particles or ringlike structures. got7fsn_ti pr 2012-12-11T14:58:16Z NIF_Subcellular:sao2114874506 cellular_component owl:Class
GO:0001015 biolink:NamedThing snoRNA transcription by RNA polymerase II The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. got7fsn_ti snoRNA transcription from an RNA polymerase II promoter https://github.com/geneontology/go-ontology/issues/14854 krc 2010-08-18T07:21:18Z biological_process owl:Class
GO:0010672 biolink:NamedThing regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. got7fsn_ti regulation of transcription from RNA polymerase II promoter, meiotic|regulation of meiosis by regulation of transcription from RNA polymerase II promoter mah 2012-04-20T02:45:12Z GO:1900401 biological_process owl:Class
GO:0051037 biolink:NamedThing regulation of transcription involved in meiotic cell cycle Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle. got7fsn_ti meiotic regulation of transcription|regulation of transcription, meiotic biological_process owl:Class
GO:1902903 biolink:NamedThing regulation of supramolecular fiber organization Any process that modulates the frequency, rate or extent of supramolecular fiber organization. got7fsn_ti regulation of fibril organisation HSPA8, human, P11142 in PMID:23921388 inferred from direct assay to negatively regulate fibrillation of alpha-Syn in vitro rl 2014-04-15T16:46:36Z biological_process owl:Class
GO:0004502 biolink:NamedThing kynurenine 3-monooxygenase activity Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+). got7fsn_ti L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)|kynurenine hydroxylase activity|L-kynurenine-3-hydroxylase activity|kynurenine 3-hydroxylase activity RHEA:20545|KEGG_REACTION:R01960|MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN|Reactome:R-HSA-71200|EC:1.14.13.9 molecular_function owl:Class
GO:0004565 biolink:NamedThing beta-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. got7fsn_ti beta-lactosidase activity|oryzatym|beta-D-galactanase activity|hydrolact|lactose hydrolysis|maxilact|exo-(1->4)-beta-D-galactanase activity|lactozym|trilactase activity|beta-D-galactoside galactohydrolase activity|S 2107|sumiklat|beta-D-lactosidase activity Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase. Reactome:R-HSA-2265534|Reactome:R-HSA-2090079|Reactome:R-HSA-9036061|MetaCyc:3.2.1.23-RXN|Reactome:R-HSA-1606312|EC:3.2.1.23|Reactome:R-HSA-1793217|MetaCyc:BGALACT-PWY|Reactome:R-HSA-1605624|Reactome:R-HSA-1630306 molecular_function owl:Class
GO:0046258 biolink:NamedThing anaerobic 2,4,6-trinitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, in the absence of oxygen. got7fsn_ti anaerobic 2,4,6-trinitrotoluene breakdown|anaerobic 2,4,6-trinitrotoluene degradation|anaerobic 2,4,6-trinitrotoluene catabolism biological_process owl:Class
GO:0046256 biolink:NamedThing 2,4,6-trinitrotoluene catabolic process The chemical reactions and pathways resulting in the breakdown of 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. got7fsn_ti 2,4,6-trinitrotoluene degradation|2,4,6-trinitrotoluene breakdown|2,4,6-trinitrotoluene catabolism biological_process owl:Class
GO:0009543 biolink:NamedThing chloroplast thylakoid lumen The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana. got7fsn_ti cellular_component owl:Class
GO:1990314 biolink:NamedThing cellular response to insulin-like growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. got7fsn_ti cellular response to insulin-like growth factor sl 2014-03-07T19:38:21Z biological_process owl:Class
GO:0050289 biolink:NamedThing spermidine dehydrogenase activity Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor. got7fsn_ti spermidine:(acceptor) oxidoreductase activity|spermidine:acceptor oxidoreductase activity EC:1.5.99.6|MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN|RHEA:14273 molecular_function owl:Class
GO:2000211 biolink:NamedThing regulation of glutamate metabolic process Any process that modulates the frequency, rate or extent of glutamate metabolic process. got7fsn_ti regulation of glutamic acid metabolic process|regulation of glutamate metabolism|regulation of glutamic acid metabolism mah 2010-11-03T02:43:51Z biological_process owl:Class
GO:0000820 biolink:NamedThing regulation of glutamine family amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. got7fsn_ti regulation of glutamine family amino acid metabolism biological_process owl:Class
GO:0008811 biolink:NamedThing chloramphenicol O-acetyltransferase activity Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA. got7fsn_ti CAT I|chloramphenicol transacetylase activity|CAT III|CAT II|chloramphenicol acetyltransferase activity|acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity|chloramphenicol acetylase activity EC:2.3.1.28|KEGG_REACTION:R03065|RHEA:18421|MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:0030041 biolink:NamedThing actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament. got7fsn_ti actin polymerization|actin polymerizing activity biological_process owl:Class
GO:0060972 biolink:NamedThing left/right pattern formation The pattern specification process that results in the subdivision of the left/right axis in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment. got7fsn_ti dph 2009-10-06T10:25:58Z biological_process owl:Class
GO:2000082 biolink:NamedThing regulation of L-ascorbic acid biosynthetic process Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process. got7fsn_ti regulation of L-ascorbic acid formation|regulation of L-ascorbic acid biosynthesis|regulation of L-ascorbic acid synthesis|regulation of ascorbate biosynthetic process|regulation of vitamin C biosynthetic process|regulation of ascorbate biosynthesis|regulation of L-ascorbic acid anabolism|regulation of vitamin C biosynthesis tb 2010-08-27T11:26:16Z biological_process owl:Class
GO:0005056 biolink:NamedThing tiggrin receptor activity Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0110143 biolink:NamedThing magnetosome A membrane-bound organelle that envelops particles of magnetic iron minerals in magnetotactic bacteria. Magnetosomes form linear chains that align along the cellular motility axis at midcell and function in bacterial navigation along the Earth's magnetic field. They are formed by invagination of the cell inner membrane; in some species they remain connected to the inner membrane, in others they pinch off to form independent intracellular vesicles. got7fsn_ti kmv 2019-05-30T17:31:21Z cellular_component owl:Class
GO:0071009 biolink:NamedThing U4atac/U6atac x U5 tri-snRNP complex A spliceosomal snRNP complex that is formed by the association of the U4atac/U6atac and U5 snRNPs. got7fsn_ti U4atac/U6atac.U5 snRNP complex mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0047341 biolink:NamedThing fucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: beta-L-fucose 1-phosphate + GTP = diphosphate + GDP-L-fucose. got7fsn_ti GDP-L-fucose pyrophosphorylase activity|GDP fucose pyrophosphorylase activity|GDP-fucose diphosphorylase activity|guanosine diphosphate L-fucose pyrophosphorylase activity|GTP:beta-L-fucose-1-phosphate guanylyltransferase activity|GDP-fucose pyrophosphorylase activity|GTP:L-fucose-1-phosphate guanylyltransferase activity|GTP:fucose-1-phosphate guanylyltransferase activity EC:2.7.7.30|Reactome:R-HSA-6787533|RHEA:13549|MetaCyc:2.7.7.30-RXN|KEGG_REACTION:R01951 molecular_function owl:Class
GO:0098600 biolink:NamedThing selenomethionine gamma-lyase activity Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid. got7fsn_ti dos 2014-04-15T15:00:28Z Reactome:R-HSA-2408537 molecular_function owl:Class
GO:0047500 biolink:NamedThing (+)-borneol dehydrogenase activity Catalysis of the reaction: (+)-borneol + NAD(+) = (1R, 4R)-camphor + H(+) + NADH. got7fsn_ti (+)-borneol:NAD+ oxidoreductase activity|bicyclic monoterpenol dehydrogenase activity KEGG_REACTION:R02944|EC:1.1.1.198|RHEA:17329|MetaCyc:+-BORNEOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0008814 biolink:NamedThing citrate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA. got7fsn_ti acetyl-CoA:citrate CoA-transferase activity MetaCyc:CITTRANS-RXN|EC:2.8.3.10|RHEA:19405 molecular_function owl:Class
GO:0007192 biolink:NamedThing adenylate cyclase-activating serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). got7fsn_ti activation of adenylate cyclase activity by serotonin receptor signalling pathway|serotonin receptor, adenylate cyclase activating pathway|serotonin receptor, adenylyl cyclase activating pathway biological_process owl:Class
GO:0090423 biolink:NamedThing phytochelatin-metal complex formation A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex. got7fsn_ti low molecular weight phytochelatin complex formation|LWM phytochelatin complex formation tb 2012-04-20T03:46:45Z biological_process owl:Class
GO:0103062 biolink:NamedThing cis-keto-C60-meroacyl-AMP ligase activity Catalysis of the reaction: ATP(4-) + H2O + a cis-keto-C60-meroacyl-[acp] <=> diphosphoric acid + a cis-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN1G-4142 molecular_function owl:Class
GO:2000870 biolink:NamedThing regulation of progesterone secretion Any process that modulates the frequency, rate or extent of progesterone secretion. got7fsn_ti bf 2011-07-26T08:51:14Z biological_process owl:Class
GO:0071246 biolink:NamedThing cellular response to chlorate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus. got7fsn_ti mah 2009-12-03T02:45:36Z biological_process owl:Class
GO:0034264 biolink:NamedThing isopentenyl adenine metabolic process The chemical reactions and pathways involving the cytokinin 6-isopentenyladenine. got7fsn_ti isopentenyladenine metabolic process|isopentenyl adenine metabolism biological_process owl:Class
GO:0102412 biolink:NamedThing valerena-4,7(11)-diene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> valerena-4,7(11)-diene + diphosphoric acid. got7fsn_ti RHEA:34467|EC:4.2.3.139|MetaCyc:RXN-13769 molecular_function owl:Class
GO:0140022 biolink:NamedThing cnida A giant secretory organelle that comprises a bulb-shape capsule containing a coiled hollow tubule structure attached to it. A cnida defines the phylum Cnidaria. got7fsn_ti cnidae (plural) cjm 2017-04-12T15:12:20Z cellular_component owl:Class
GO:0018560 biolink:NamedThing protocatechuate 3,4-dioxygenase type II activity Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0581 molecular_function owl:Class
GO:0030116 biolink:NamedThing glial cell-derived neurotrophic factor receptor binding A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors. got7fsn_ti glial cell line-derived neurotrophic factor receptor binding|glial cell line-derived neurotrophic factor receptor ligand molecular_function owl:Class
GO:0060931 biolink:NamedThing sinoatrial node cell development The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node. got7fsn_ti SAN cell development|sinus node cell development|SA node cell development dph 2009-09-29T12:05:47Z biological_process owl:Class
GO:0031059 biolink:NamedThing histone deacetylation at centromere The removal of acetyl groups from histones in centromeric DNA. got7fsn_ti biological_process owl:Class
GO:0110058 biolink:NamedThing positive regulation of blood vessel endothelial cell differentiation Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation. got7fsn_ti kmv 2017-10-23T14:38:19Z biological_process owl:Class
GO:0045603 biolink:NamedThing positive regulation of endothelial cell differentiation Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. got7fsn_ti upregulation of endothelial cell differentiation|stimulation of endothelial cell differentiation|activation of endothelial cell differentiation|up-regulation of endothelial cell differentiation|up regulation of endothelial cell differentiation biological_process owl:Class
GO:0032407 biolink:NamedThing MutSalpha complex binding Binding to a MutSalpha mismatch repair complex. got7fsn_ti molecular_function owl:Class
GO:0008209 biolink:NamedThing androgen metabolic process The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. got7fsn_ti androgen metabolism biological_process owl:Class
GO:0010475 biolink:NamedThing galactose-1-phosphate guanylyltransferase (GDP) activity Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose. got7fsn_ti GDP:galactose-1-phosphate guanyltransferase activity molecular_function owl:Class
GO:0035697 biolink:NamedThing CD8-positive, alpha-beta T cell extravasation The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue. got7fsn_ti bf 2011-02-28T03:08:49Z biological_process owl:Class
GO:0004579 biolink:NamedThing dolichyl-diphosphooligosaccharide-protein glycotransferase activity Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. got7fsn_ti dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity|dolichyldiphosphooligosaccharide-protein glycosyltransferase activity|dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity|dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity|dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity|oligomannosyltransferase activity|dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity|asparagine N-glycosyltransferase activity Reactome:R-HSA-9694793|Reactome:R-HSA-446209|MetaCyc:2.4.1.119-RXN|RHEA:22980|EC:2.4.99.18 molecular_function owl:Class
GO:0004576 biolink:NamedThing oligosaccharyl transferase activity Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. got7fsn_ti oligosaccharide transferase activity molecular_function owl:Class
GO:0018063 biolink:NamedThing cytochrome c-heme linkage The linkage of cytochromes and other heme proteins to heme. got7fsn_ti cytochrome c-haem linkage RESID:AA0134|RESID:AA0135 biological_process owl:Class
GO:0042322 biolink:NamedThing negative regulation of circadian sleep/wake cycle, REM sleep Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep. got7fsn_ti inhibition of circadian sleep/wake cycle, REM sleep|negative regulation of REM sleep|downregulation of circadian sleep/wake cycle, REM sleep|down regulation of circadian sleep/wake cycle, REM sleep|down-regulation of circadian sleep/wake cycle, REM sleep biological_process owl:Class
GO:2000859 biolink:NamedThing negative regulation of aldosterone secretion Any process that stops, prevents or reduces the frequency, rate or extent of aldosterone secretion. got7fsn_ti bf 2011-07-26T08:47:31Z biological_process owl:Class
GO:0050194 biolink:NamedThing phosphonoacetaldehyde hydrolase activity Catalysis of the reaction: H(2)O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate. got7fsn_ti phosphonoacetylaldehyde phosphonohydrolase activity|2-oxoethylphosphonate phosphonohydrolase activity|2-phosphonoacetylaldehyde phosphonohydrolase activity|phosphonatase activity KEGG_REACTION:R00747|EC:3.11.1.1|RHEA:18905|MetaCyc:PHOSPHONOACETALDEHYDE-HYDROLASE-RXN molecular_function owl:Class
GO:0044070 biolink:NamedThing regulation of anion transport Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1903792 biolink:NamedThing negative regulation of anion transport Any process that stops, prevents or reduces the frequency, rate or extent of anion transport. got7fsn_ti downregulation of anion transport|down-regulation of anion transport|inhibition of anion transport|down regulation of anion transport sl 2015-01-12T21:50:20Z biological_process owl:Class
GO:0036322 biolink:NamedThing pancreatic polypeptide secretion The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas. got7fsn_ti PP secretion bf 2012-09-04T14:39:03Z biological_process owl:Class
GO:0043366 biolink:NamedThing beta selection The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell. got7fsn_ti biological_process owl:Class
GO:0007112 biolink:NamedThing male meiosis cytokinesis A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells. got7fsn_ti cytokinesis after male meiosis|cytokinesis involved in male meiotic cell cycle biological_process owl:Class
GO:0098928 biolink:NamedThing presynaptic signal transduction Signal transduction in which the initial step occurs in a presynapse. got7fsn_ti presynaptic signaling pathway Do not directly annotate. This term intended for grouping. Annotate to either a subclass or to some other subclass of signal transduction extended with has_start_location/occurs_in presynapse or one of its parts. Such extensions will result in automatic annotation to this term. biological_process owl:Class
GO:0110134 biolink:NamedThing meiotic drive A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis. got7fsn_ti kmv 2019-01-02T17:37:09Z biological_process owl:Class
GO:0034896 biolink:NamedThing 3-formiminopyruvate hydrolase activity Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3. got7fsn_ti UM-BBD_reactionID:r1400|EC:3.5.99.- molecular_function owl:Class
GO:0016158 biolink:NamedThing 3-phytase activity Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate. got7fsn_ti phytase activity|myo-inositol-hexakisphosphate 3-phosphohydrolase activity|myo-inositol-hexaphosphate 3-phosphohydrolase activity|1-phytase activity|phytate 1-phosphatase activity|phytate 3-phosphatase activity EC:3.1.3.8|MetaCyc:RXN0-1001|RHEA:16989 molecular_function owl:Class
GO:0045576 biolink:NamedThing mast cell activation The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. got7fsn_ti biological_process owl:Class
GO:0018823 biolink:NamedThing cyclohexa-1,5-dienecarbonyl-CoA hydratase activity Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA. got7fsn_ti cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity|6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)|cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity|dienoyl-CoA hydratase activity|cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity|cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity MetaCyc:4.2.1.100-RXN|EC:4.2.1.100|RHEA:21856|KEGG_REACTION:R05597|UM-BBD_reactionID:r0203 molecular_function owl:Class
GO:0052332 biolink:NamedThing modification by organism of membrane in other organism involved in symbiotic interaction The process in which an organism effects a change in the structure or function of a cellular membrane of a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti modification by organism of cell membrane in other organism involved in symbiotic interaction|modification by organism of cell membrane in other organism during symbiotic interaction biological_process owl:Class
GO:0048627 biolink:NamedThing myoblast development The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0102816 biolink:NamedThing UDP-D-glucose:delphinidin 3-O-glucosyl-5-O-caffeoylglucoside -O-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-glucosyl-5-O-caffeoylglucoside <=> H+ + delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + UDP. got7fsn_ti RHEA:35423|EC:2.4.1.298|MetaCyc:RXN-8234 molecular_function owl:Class
GO:0042245 biolink:NamedThing RNA repair Any process that results in the repair of damaged RNA. got7fsn_ti biological_process owl:Class
GO:0004450 biolink:NamedThing isocitrate dehydrogenase (NADP+) activity Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. got7fsn_ti NADP-specific isocitrate dehydrogenase activity|isocitrate (NADP) dehydrogenase activity|dual-cofactor-specific isocitrate dehydrogenase activity|NADP(+)-linked isocitrate dehydrogenase activity|NADP-dependent isocitrate dehydrogenase activity|isocitrate dehydrogenase (NADP-dependent) activity|NADP-linked isocitrate dehydrogenase activity|NADP isocitric dehydrogenase activity|isocitrate dehydrogenase (NADP) activity|NADP(+)-ICDH activity|isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity|NADP-dependent isocitric dehydrogenase activity|isocitrate:NADP+ oxidoreductase (decarboxylating)|NADP(+)-IDH activity Reactome:R-HSA-450984|Reactome:R-HSA-389550|Reactome:R-HSA-389540|RHEA:19629|EC:1.1.1.42|MetaCyc:ISOCITDEH-RXN molecular_function owl:Class
GO:0097703 biolink:NamedThing cellular response to pulsatile fluid shear stress Any response to pulsatile fluid shear stress that occurs at the level of a cell. got7fsn_ti pr 2016-01-27T14:18:23Z biological_process owl:Class
GO:0050528 biolink:NamedThing acyloxyacyl hydrolase activity Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid. got7fsn_ti EC:3.1.1.77|RHEA:12032|MetaCyc:3.1.1.77-RXN molecular_function owl:Class
GO:0102934 biolink:NamedThing costunolide synthase activity Catalysis of the reaction: germacra-1(10),4,11(13)-trien-12-oate + O2 + NADPH + 2 H+ = costunolide + 2 H2O + NADP. got7fsn_ti RHEA:28230|MetaCyc:RXN-8971|EC:1.14.14.150 molecular_function owl:Class
GO:0005046 biolink:NamedThing KDEL sequence binding Binding to a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum. got7fsn_ti KDEL receptor activity molecular_function owl:Class
GO:0043456 biolink:NamedThing regulation of pentose-phosphate shunt Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis. got7fsn_ti regulation of pentose phosphate pathway|regulation of pentose-phosphate pathway|regulation of pentose phosphate shunt biological_process owl:Class
GO:0120055 biolink:NamedThing small intestinal transit Migration of ingested material along the length of the small intestine. got7fsn_ti small intestine transit|small bowel transit krc 2017-06-13T20:46:41Z biological_process owl:Class
GO:0039675 biolink:NamedThing exit of virus from host cell nucleus through nuclear pore The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore. got7fsn_ti viral enome export through nuclear pore|exit of virus from host cell nucleus through nuclear pore complex|nuclear pore exit of virus bf 2013-09-25T14:10:03Z VZ:1953 biological_process owl:Class
GO:0097753 biolink:NamedThing membrane bending A membrane organization process resulting in the bending of a membrane. got7fsn_ti membrane curvature pr 2017-01-25T16:37:06Z biological_process owl:Class
GO:0102360 biolink:NamedThing daphnetin 3-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + 7,8-dihydroxycoumarin <=> UDP(3-) + 3-O-beta-D-glucosyl-daphnetin + H+. got7fsn_ti EC:2.4.1.91|MetaCyc:RXN-13452 molecular_function owl:Class
GO:0008190 biolink:NamedThing eukaryotic initiation factor 4E binding Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. got7fsn_ti eIF4E binding molecular_function owl:Class
GO:0031369 biolink:NamedThing translation initiation factor binding Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. got7fsn_ti molecular_function owl:Class
GO:0060131 biolink:NamedThing corticotropin hormone secreting cell development The process whose specific outcome is the progression of a corticotropic hormone secreting cell over time, from its formation to the mature structure. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin. got7fsn_ti corticotrophin hormone secreting cell development|corticotrope development|corticotroph development|adrenocorticotropic hormone secreting cell development|adrenocorticotrophic hormone secreting cell development biological_process owl:Class
GO:0099611 biolink:NamedThing regulation of action potential firing threshold Any process that regulates the potential at which an axon potential is triggered. got7fsn_ti biological_process owl:Class
GO:0021850 biolink:NamedThing subpallium glioblast cell division The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes. got7fsn_ti glioblast cell division in subpallium|glioblast division in ventral telencephalon biological_process owl:Class
GO:0048860 biolink:NamedThing glioblast division The process resulting in the physical partitioning and separation of a glioblast into daughter cells. got7fsn_ti biological_process owl:Class
GO:0098626 biolink:NamedThing methylseleninic acid reductase activity Catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O. got7fsn_ti Reactome:R-HSA-5263616 molecular_function owl:Class
GO:0072587 biolink:NamedThing DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity Binds to and increases the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. got7fsn_ti mah 2011-02-09T05:34:47Z molecular_function owl:Class
GO:0001671 biolink:NamedThing ATPase activator activity Binds to and increases the activity of an ATP hydrolysis activity. got7fsn_ti ATPase stimulator activity https://github.com/geneontology/go-ontology/issues/20955 Reactome:R-HSA-5251955|Reactome:R-HSA-5251959 molecular_function owl:Class
GO:0000472 biolink:NamedThing endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA. got7fsn_ti endonucleolytic cleavage at A1 biological_process owl:Class
GO:0031554 biolink:NamedThing regulation of DNA-templated transcription, termination Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. got7fsn_ti transcription antiterminator activity|regulation of DNA-dependent transcription, termination|regulation of termination of DNA-dependent transcription|regulation of transcription termination, DNA-dependent biological_process owl:Class
GO:0102476 biolink:NamedThing pinocembrin 2-hydroxylase activity Catalysis of the reaction: pinocembrin + NADPH + O2 + H+ <=> 2,5,7-trihydroxyflavanone + NADP + H2O. got7fsn_ti RHEA:57592|MetaCyc:RXN-14083 molecular_function owl:Class
GO:0009027 biolink:NamedThing tartrate dehydrogenase activity Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+. got7fsn_ti mesotartrate dehydrogenase activity|tartrate:NAD+ oxidoreductase activity RHEA:15209|MetaCyc:TARTRATE-DEHYDROGENASE-RXN|EC:1.1.1.93 molecular_function owl:Class
GO:0052001 biolink:NamedThing type IV pili-dependent localized adherence to host Attachment of bacterial clusters to the surface of the host in a type IV pili dependent manner. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0043466 biolink:NamedThing pyrimidine nucleobase fermentation The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP. got7fsn_ti pyrimidine base fermentation|pyrimidine fermentation biological_process owl:Class
GO:0019666 biolink:NamedThing nitrogenous compound fermentation The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP. got7fsn_ti nitrogenous compound catabolic process biological_process owl:Class
GO:0070935 biolink:NamedThing 3'-UTR-mediated mRNA stabilization An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. got7fsn_ti 3'-untranslated region-mediated mRNA stabilization mah 2009-09-21T03:08:20Z biological_process owl:Class
GO:0097718 biolink:NamedThing disordered domain specific binding Binding to a disordered domain of a protein. got7fsn_ti disordered protein domain specific binding pr 2016-08-23T16:42:51Z molecular_function owl:Class
GO:0098628 biolink:NamedThing peptidyl-N-phospho-arginine dephosphorylation The removal of phosphate residues from peptidyl-N-phospho-arginine to form peptidyl-arginine. got7fsn_ti dos 2014-04-17T18:03:31Z biological_process owl:Class
GO:0008612 biolink:NamedThing peptidyl-lysine modification to peptidyl-hypusine The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine. got7fsn_ti hypusinylation|hypusine formation|protein hypusination|hypusine formation from peptidyl-lysine|hypusine biosynthetic process from peptidyl-lysine|hypusine synthesis from peptidyl-lysine|hypusine biosynthesis|hypusine anabolism from peptidyl-lysine|hypusine biosynthetic process|hypusine anabolism|hypusine synthesis GO:0046515 RESID:AA0116 biological_process owl:Class
GO:0043580 biolink:NamedThing periplasmic space organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi. got7fsn_ti periplasmic space organization and biogenesis|periplasmic space organisation biological_process owl:Class
GO:0070593 biolink:NamedThing dendrite self-avoidance The process in which dendrites recognize and avoid contact with sister dendrites from the same cell. got7fsn_ti dendrite repulsion mah 2009-04-28T03:29:14Z biological_process owl:Class
GO:0032169 biolink:NamedThing prospore septin ring A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins. got7fsn_ti cellular_component owl:Class
GO:0008628 biolink:NamedThing hormone-mediated apoptotic signaling pathway A series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered. got7fsn_ti induction of apoptosis by hormones|apoptotic signaling pathway in response to hormone http://wiki.geneontology.org/index.php/Apoptosis_Curation_Manual#Other_children_of_apoptotic_signaling_pathway This term is placed under GO:0097190 apoptotic signaling pathway, rather than under one of its more specific children terms, to cover for the variety of apoptosis signaling mechanisms that different hormones may use. biological_process owl:Class
GO:0035843 biolink:NamedThing endonuclear canal A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope. got7fsn_ti bf 2011-05-06T01:45:03Z cellular_component owl:Class
GO:0033722 biolink:NamedThing malonate-semialdehyde dehydrogenase activity Catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+. got7fsn_ti malonic semialdehyde dehydrogenase activity|3-oxopropanoate:NAD(P)+ oxidoreductase activity EC:1.2.1.15|MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0008157 biolink:NamedThing protein phosphatase 1 binding Binding to a protein phosphatase 1. got7fsn_ti molecular_function owl:Class
GO:0044728 biolink:NamedThing DNA methylation or demethylation The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. got7fsn_ti changes in DNA methylation jl 2012-10-24T14:49:41Z biological_process owl:Class
GO:0002030 biolink:NamedThing inhibitory G protein-coupled receptor phosphorylation The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site. got7fsn_ti inhibitory G-protein coupled receptor phosphorylation biological_process owl:Class
GO:0047260 biolink:NamedThing alpha,alpha-trehalose-phosphate synthase (GDP-forming) activity Catalysis of the reaction: GDP-D-glucose + glucose-6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP. got7fsn_ti GDP-glucose-glucosephosphate glucosyltransferase activity|GDPglucose-glucose-phosphate glucosyltransferase activity|GDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity|guanosine diphosphoglucose-glucose phosphate glucosyltransferase activity|GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity|trehalose phosphate synthase (GDP-forming) activity RHEA:14605|EC:2.4.1.36|MetaCyc:2.4.1.36-RXN molecular_function owl:Class
GO:0061197 biolink:NamedThing fungiform papilla morphogenesis The process in which the anatomical structures of the fungiform papilla are generated and organized. The fungiform papilla is a mushroom-shaped papilla of the tongue. got7fsn_ti dph 2010-07-27T12:26:40Z biological_process owl:Class
GO:0097238 biolink:NamedThing cellular response to methylglyoxal Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal. got7fsn_ti pr 2012-02-02T12:26:35Z biological_process owl:Class
GO:0090167 biolink:NamedThing Golgi distribution to daughter cells Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division. got7fsn_ti tb 2009-12-08T09:15:11Z biological_process owl:Class
GO:0051645 biolink:NamedThing Golgi localization Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti establishment and maintenance of Golgi localization|Golgi body localization|Golgi apparatus localization|Golgi localisation biological_process owl:Class
GO:0097156 biolink:NamedThing fasciculation of motor neuron axon The collection of motor neuron axons into a bundle of rods, known as a fascicle. got7fsn_ti pr 2011-09-16T09:20:46Z biological_process owl:Class
GO:0001122 biolink:NamedThing promoter clearance from bacterial-type RNA polymerase promoter Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor. got7fsn_ti krc 2010-12-06T03:38:10Z biological_process owl:Class
GO:0003086 biolink:NamedThing regulation of systemic arterial blood pressure by local renal renin-angiotensin The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen. got7fsn_ti biological_process owl:Class
GO:0052183 biolink:NamedThing modification by host of symbiont structure The process in which an organism effects a change in an anatomical part or cellular component of the host organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0022875 biolink:NamedThing protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti galactitol PTS transporter activity molecular_function owl:Class
GO:0015577 biolink:NamedThing galactitol transmembrane transporter activity Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. got7fsn_ti galactitol permease activity GO:0015588 RHEA:33143 molecular_function owl:Class
GO:0052750 biolink:NamedThing reactive-black-5:hydrogen-peroxide oxidoreductase activity Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O. got7fsn_ti versatile peroxidase activity ai 2011-09-21T02:33:34Z KEGG_REACTION:R07612|MetaCyc:RXN-8666|RHEA:22396|EC:1.11.1.16 molecular_function owl:Class
GO:0005091 biolink:NamedThing guanyl-nucleotide exchange factor adaptor activity The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way. got7fsn_ti molecular_function owl:Class
GO:0102115 biolink:NamedThing peptidoglycan asparagine synthase activity Catalysis of the reaction: ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ammonium + ATP = H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparaginyl)-L-lysyl-D-alanyl-D-alanine + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-11338 molecular_function owl:Class
GO:0017188 biolink:NamedThing aspartate N-acetyltransferase activity Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+). got7fsn_ti aspartate acetyltransferase activity|acetyl-CoA:L-aspartate N-acetyltransferase activity|L-aspartate N-acetyltransferase activity MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN|RHEA:14165|KEGG_REACTION:R00487|EC:2.3.1.17|Reactome:R-HSA-8954468 molecular_function owl:Class
GO:0060226 biolink:NamedThing negative regulation of retinal cone cell fate commitment Any process that increases the process in which a cell becomes committed to a retinal cone cell fate. Retinal cone cell fate commitment is the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. got7fsn_ti biological_process owl:Class
GO:0046533 biolink:NamedThing negative regulation of photoreceptor cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster. got7fsn_ti inhibition of photoreceptor differentiation|down-regulation of photoreceptor cell differentiation|downregulation of photoreceptor cell differentiation|negative regulation of photoreceptor differentiation|down-regulation of photoreceptor differentiation|inhibition of photoreceptor cell differentiation|downregulation of photoreceptor differentiation|down regulation of photoreceptor cell differentiation|down regulation of photoreceptor differentiation GO:0045674 biological_process owl:Class
GO:1900806 biolink:NamedThing ergot alkaloid catabolic process The chemical reactions and pathways resulting in the breakdown of ergot alkaloid. got7fsn_ti ergot alkaloid catabolism|ergot alkaloids catabolism|ergot alkaloid degradation|ergot alkaloids catabolic process|ergot alkaloid breakdown|ergot alkaloids degradation|ergot alkaloids breakdown di 2012-06-04T09:57:39Z biological_process owl:Class
GO:0009784 biolink:NamedThing transmembrane receptor histidine kinase activity Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate. got7fsn_ti molecular_function owl:Class
GO:0019199 biolink:NamedThing transmembrane receptor protein kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. got7fsn_ti Reactome:R-HSA-8983063|Reactome:R-HSA-8983059 molecular_function owl:Class
GO:0150056 biolink:NamedThing amylin receptor complex 1 A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 1. Amylin receptor complex 1 (AMY1) also serves as a receptor for the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM). got7fsn_ti AMY1 complex bc 2018-06-21T10:47:10Z cellular_component owl:Class
GO:0061645 biolink:NamedThing endocytic patch The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle. got7fsn_ti dph 2014-09-02T09:23:38Z cellular_component owl:Class
GO:0061230 biolink:NamedThing mesonephric juxtaglomerulus cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric juxtaglomerulus cell. got7fsn_ti dph 2010-08-19T02:36:23Z biological_process owl:Class
GO:0019473 biolink:NamedThing L-lysine catabolic process to glutarate, by acetylation The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation. got7fsn_ti L-lysine degradation to glutarate, by acetylation|L-lysine breakdown to glutarate, by acetylation MetaCyc:LYSDEGII-PWY biological_process owl:Class
GO:0019477 biolink:NamedThing L-lysine catabolic process The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid. got7fsn_ti L-lysine breakdown|L-lysine catabolism|L-lysine degradation biological_process owl:Class
GO:0050547 biolink:NamedThing vanillin synthase activity Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin. got7fsn_ti 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propionyl-CoA:vanillin lyase (acetyl-CoA-forming)|3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA vanillin-lyase (acetyl-CoA-forming) MetaCyc:4.1.2.41-RXN|KEGG_REACTION:R05773|EC:4.1.2.61|RHEA:18725 molecular_function owl:Class
GO:0044314 biolink:NamedThing protein K27-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein. got7fsn_ti protein K27-linked polyubiquitination jl 2010-06-02T11:48:08Z biological_process owl:Class
GO:0000209 biolink:NamedThing protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. got7fsn_ti polyubiquitin|protein polyubiquitylation|protein polyubiquitinylation biological_process owl:Class
GO:0102624 biolink:NamedThing scutellarein 7-methyl ether 4'-O-methyltransferase activity Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> ladanein + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-15529 molecular_function owl:Class
GO:0050564 biolink:NamedThing N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H(2)O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H(+). got7fsn_ti L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase activity|ACV synthetase activity|L-alpha-aminoadipyl-cysteinyl-valine synthetase activity|L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting) MetaCyc:6.3.2.26-RXN|EC:6.3.2.26|KEGG_REACTION:R04870|RHEA:23196 molecular_function owl:Class
GO:0048882 biolink:NamedThing lateral line development The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear. got7fsn_ti LL development biological_process owl:Class
GO:0039690 biolink:NamedThing positive stranded viral RNA replication A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA. got7fsn_ti ss(+) viral RNA replication bf 2013-10-17T15:45:40Z VZ:1116 biological_process owl:Class
GO:0140450 biolink:NamedThing protein targeting to Golgi apparatus The process of targeting specific proteins to the Golgi apparatus. Usually requires an organelle-specific protein sequence motif or a protein modification (for example a palmitoylation). got7fsn_ti pg 2020-04-08T13:10:10Z biological_process owl:Class
GO:0021806 biolink:NamedThing initiation of movement involved in cerebral cortex radial glia guided migration The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex. got7fsn_ti initiation of movement involved in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:0047891 biolink:NamedThing flavone 7-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + 5,7,3',4'-tetrahydroxyflavone = UDP + 7-O-beta-D-glucosyl-5,7,3',4'-tetrahydroxyflavone. got7fsn_ti UDP-glucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity|UDPglucose-luteolin beta-D-glucosyltransferase activity|uridine diphosphoglucose-luteolin glucosyltransferase activity|flavone 7-O-b-glucosyltransferase activity|uridine diphosphoglucose-apigenin 7-O-glucosyltransferase activity|UDPglucose:5,7,3',4'-tetrahydroxyflavone 7-O-beta-D-glucosyltransferase activity|UDP-glucose-apigenin beta-glucosyltransferase activity|UDP-glucose-luteolin beta-D-glucosyltransferase activity|UDPglucose-apigenin beta-glucosyltransferase activity EC:2.4.1.81|RHEA:19577|MetaCyc:FLAVONE-7-O-BETA-GLUCOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0034841 biolink:NamedThing mentha-1,3-dione-CoA ligase activity Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA. got7fsn_ti UM-BBD_reactionID:r1186 molecular_function owl:Class
GO:0016584 biolink:NamedThing nucleosome positioning Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another. got7fsn_ti nucleosome spacing biological_process owl:Class
GO:0038001 biolink:NamedThing paracrine signaling The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other. got7fsn_ti paracrine signalling This term should be used with caution, and only used when the signaling between cells has been clearly distinguished from endocrine signaling. bf 2011-02-25T02:11:00Z biological_process owl:Class
GO:0017102 biolink:NamedThing methionyl glutamyl tRNA synthetase complex A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers. got7fsn_ti cellular_component owl:Class
GO:0044098 biolink:NamedThing DNA secretion by the type IV secretion system The controlled release of DNA by a cell, via the type IV secretion system. got7fsn_ti DNA secretion via the type IV secretion system jl 2009-06-09T02:26:57Z biological_process owl:Class
GO:0036352 biolink:NamedThing histone H2A-K15 ubiquitination The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin. got7fsn_ti histone H2A ubiquitination (H2A-K15) bf 2012-09-19T11:49:03Z biological_process owl:Class
GO:0070468 biolink:NamedThing dentin extracellular matrix secretion The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin. got7fsn_ti dentine secretion|dentin secretion|predentin secretion biological_process owl:Class
GO:0045484 biolink:NamedThing L-lysine 6-transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine. got7fsn_ti lysine epsilon-transaminase activity|L-lysine:2-oxoglutarate 6-aminotransferase activity|lysine:2-ketoglutarate 6-aminotransferase activity|L-lysine aminotransferase activity|lysine 6-aminotransferase activity|L-lysine-alpha-ketoglutarate 6-aminotransferase activity|L-lysine transaminase activity|L-lysine-alpha-ketoglutarate aminotransferase activity|lysine epsilon-aminotransferase activity EC:2.6.1.36|MetaCyc:L-LYSINE-AMINOTRANSFERASE-RXN|KEGG_REACTION:R00457|RHEA:21200 molecular_function owl:Class
GO:0072140 biolink:NamedThing DCT cell development The process whose specific outcome is the progression of a distal convoluted tubule cell over time, from its formation to the mature structure. got7fsn_ti distal convoluted tubule cell development mah 2010-02-24T01:36:21Z biological_process owl:Class
GO:0102723 biolink:NamedThing UDP-glucose:curcumin glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + curcumin = curcumin monoglucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-7062 molecular_function owl:Class
GO:2001001 biolink:NamedThing negative regulation of xylan catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of xylan catabolic process. got7fsn_ti negative regulation of xylan breakdown|negative regulation of xylan degradation|negative regulation of xylan catabolism tt 2011-08-08T03:23:18Z biological_process owl:Class
GO:0110052 biolink:NamedThing toxic metabolite repair A cellular process that, through single- or multi-step enzymatic reactions, repairs toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites. got7fsn_ti kmv 2017-09-08T15:19:16Z biological_process owl:Class
GO:0110051 biolink:NamedThing metabolite repair A cellular process that, through single- or multi-step enzymatic reactions, repairs useless or toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites. got7fsn_ti kmv 2017-09-08T15:16:01Z biological_process owl:Class
GO:0045974 biolink:NamedThing regulation of translation, ncRNA-mediated Any process, mediated by small non-coding RNAs, that modulates the frequency, rate or extent that mRNAs are effectively translated into protein. got7fsn_ti biological_process owl:Class
GO:0099119 biolink:NamedThing 3-demethylubiquinol-8 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinol-8 = S-adenosyl-L-homocysteine + ubiquinol-8. got7fsn_ti molecular_function owl:Class
GO:0120097 biolink:NamedThing glycosylphosphatidylinositol-mannosyltransferase II complex A protein complex that is involved in the transfer of the second mannose to the glycosylphosphatidylinositol (GPI) during GPI precursor assembly. In yeast S. cerevisiae this complex consists of GPI18p and PGA1p. got7fsn_ti GPI-MT-I complex krc 2017-09-18T20:51:56Z cellular_component owl:Class
GO:0050390 biolink:NamedThing valine decarboxylase activity Catalysis of the reaction: L-valine + H(+) = 2-methylpropanamine + CO(2). got7fsn_ti L-valine carboxy-lyase (2-methylpropanamine-forming)|leucine decarboxylase activity|L-valine carboxy-lyase activity MetaCyc:VALINE-DECARBOXYLASE-RXN|RHEA:18989|UM-BBD_reactionID:r1052|EC:4.1.1.14|KEGG_REACTION:R01437 molecular_function owl:Class
GO:0004655 biolink:NamedThing porphobilinogen synthase activity Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. got7fsn_ti 5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)|delta-aminolevulinic dehydratase activity|delta-aminolevulinate dehydratase activity|delta-aminolevulinic acid dehydrase activity|5-levulinic acid dehydratase activity|aminolevulinate dehydratase activity|delta-aminolevulinic acid dehydratase activity|aminolevulinic dehydratase activity|5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming) EC:4.2.1.24|Reactome:R-HSA-189439|RHEA:24064|MetaCyc:PORPHOBILSYNTH-RXN|KEGG_REACTION:R00036 molecular_function owl:Class
GO:0102348 biolink:NamedThing trans-docosan-2-enoyl-CoA reductase activity Catalysis of the reaction: behenoyl-CoA + NADP <=> trans-2-docosenoyl-CoA + NADPH + H+. got7fsn_ti MetaCyc:RXN-13307 molecular_function owl:Class
GO:0010636 biolink:NamedThing positive regulation of mitochondrial fusion Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. got7fsn_ti biological_process owl:Class
GO:0006710 biolink:NamedThing androgen catabolic process The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. got7fsn_ti androgen degradation|androgen catabolism|androgen breakdown biological_process owl:Class
GO:0047553 biolink:NamedThing 2-oxoglutarate synthase activity Catalysis of the reaction: 2-oxoglutarate + CoA + oxidized ferredoxin = succinyl-CoA + CO2 + reduced ferredoxin. got7fsn_ti alpha-ketoglutarate synthase activity|alpha-ketoglutarate-ferredoxin oxidoreductase activity|2-ketoglutarate ferredoxin oxidoreductase activity|2-oxoglutarate ferredoxin oxidoreductase activity|2-oxoglutarate:ferredoxin oxidoreductase activity|KGOR activity|2-oxoglutarate:ferredoxin 2-oxidoreductase (CoA-succinylating)|2-oxoglutarate:ferredoxin 2-oxidoreductase (decarboxylating) EC:1.2.7.3|RHEA:17297|MetaCyc:2-OXOGLUTARATE-SYNTHASE-RXN molecular_function owl:Class
GO:0018576 biolink:NamedThing catechol 1,2-dioxygenase activity Catalysis of the reaction: catechol + O2 = cis,cis-muconate. got7fsn_ti pyrocatechase activity|catechol 1,2-oxygenase activity|1,2-pyrocatechase activity|CD II|CD I|catechol-oxygen 1,2-oxidoreductase activity|pyrocatechol 1,2-dioxygenase activity|catechol:oxygen 1,2-oxidoreductase activity|catechase activity EC:1.13.11.1|UM-BBD_enzymeID:e0064|MetaCyc:CATECHOL-12-DIOXYGENASE-RXN|RHEA:23852 molecular_function owl:Class
GO:0050095 biolink:NamedThing methionine decarboxylase activity Catalysis of the reaction: L-methionine + H(+) = 3-methylthiopropanamine + CO(2). got7fsn_ti L-methionine carboxy-lyase activity|L-methionine carboxy-lyase (3-methylthiopropanamine-forming)|L-methionine decarboxylase activity RHEA:17757|KEGG_REACTION:R00656|MetaCyc:METHIONINE-DECARBOXYLASE-RXN|EC:4.1.1.57 molecular_function owl:Class
GO:0014811 biolink:NamedThing negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. got7fsn_ti biological_process owl:Class
GO:0044081 biolink:NamedThing modulation by symbiont of host nitric oxide-mediated signal transduction Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO). got7fsn_ti modulation by symbiont of host nitric oxide mediated signal transduction|modulation of host nitric oxide-mediated signalling by symbiont|modulation of host nitric oxide-mediated signaling by symbiont|modulation of host nitric oxide-mediated signal transduction by symbiont|regulation by symbiont of host nitric oxide-mediated signal transduction biological_process owl:Class
GO:0010749 biolink:NamedThing regulation of nitric oxide mediated signal transduction Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO). got7fsn_ti regulation of nitric oxide-mediated signal transduction biological_process owl:Class
GO:0140571 biolink:NamedThing transmembrane ascorbate ferrireductase activity Oxidation of Fe(3+) to Fe(2+) on the outer side of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction. got7fsn_ti L-ascorbate-cytochrome-b5 reductase activity|L-ascorbate:ferricytochrome-b5 oxidoreductase activity|ascorbate-cytochrome b5 reductase activity pg 2020-12-18T16:25:06Z RHEA:30403|MetaCyc:1.10.2.1-RXN|EC:7.2.1.3 molecular_function owl:Class
GO:0071717 biolink:NamedThing thromboxane transport The directed movement of thromboxanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A thromboxane is any of a class of oxygenated oxane derivatives, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels. got7fsn_ti mah 2010-03-10T03:03:49Z biological_process owl:Class
GO:0038025 biolink:NamedThing reelin receptor activity Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti reeler receptor activity bf 2011-08-02T12:01:25Z molecular_function owl:Class
GO:0018632 biolink:NamedThing 4-nitrophenol 4-monooxygenase activity Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone. got7fsn_ti RHEA:34327|MetaCyc:RXN-8739|UM-BBD_reactionID:r0226|EC:1.14.13.167 molecular_function owl:Class
GO:0102071 biolink:NamedThing 9,10-epoxy-18-hydroxystearate hydrolase activity Catalysis of the reaction: 9,10-epoxy-18-hydroxystearate + H2O <=> 9,10,18-trihydroxystearate. got7fsn_ti MetaCyc:RXN-1065 molecular_function owl:Class
GO:0071291 biolink:NamedThing cellular response to selenium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion. got7fsn_ti mah 2009-12-10T04:15:52Z biological_process owl:Class
GO:0018690 biolink:NamedThing 4-methoxybenzoate monooxygenase (O-demethylating) activity Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O. got7fsn_ti piperonylate-4-O-demethylase activity|4-methoxybenzoate monooxygenase activity|p-anisic O-demethylase activity|4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)|4-methoxybenzoate O-demethylase activity|4-methoxybenzoate 4-monooxygenase (O-demethylating) UM-BBD_reactionID:r0154|KEGG_REACTION:R01306|EC:1.14.99.15|RHEA:18613|MetaCyc:1.14.99.15-RXN molecular_function owl:Class
GO:0046827 biolink:NamedThing positive regulation of protein export from nucleus Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm. got7fsn_ti positive regulation of protein-nucleus export|stimulation of protein export from nucleus|positive regulation of protein transport from nucleus to cytoplasm|positive regulation of protein export from cell nucleus|up-regulation of protein export from nucleus|activation of protein export from nucleus|up regulation of protein export from nucleus|positive regulation of protein export out of nucleus|upregulation of protein export from nucleus biological_process owl:Class
GO:0015312 biolink:NamedThing polyamine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out). got7fsn_ti polyamine:hydrogen antiporter activity molecular_function owl:Class
GO:0000147 biolink:NamedThing actin cortical patch assembly Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. got7fsn_ti biological_process owl:Class
GO:0035663 biolink:NamedThing Toll-like receptor 2 binding Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response. got7fsn_ti TLR2 binding bf 2011-02-01T10:21:51Z molecular_function owl:Class
GO:0046982 biolink:NamedThing protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer. got7fsn_ti molecular_function owl:Class
GO:0036047 biolink:NamedThing peptidyl-lysine demalonylation The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein. got7fsn_ti bf 2011-12-12T09:39:17Z biological_process owl:Class
GO:0036046 biolink:NamedThing protein demalonylation The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide. got7fsn_ti bf 2011-12-12T09:38:26Z biological_process owl:Class
GO:0018137 biolink:NamedThing peptide cross-linking via glycine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti RESID:AA0241 biological_process owl:Class
GO:0071708 biolink:NamedThing immunoglobulin light chain V-J recombination The process in which immunoglobulin light chain V and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). got7fsn_ti immunoglobulin V(D)J recombination|immunoglobulin V-J joining|immunoglobulin V(D)J joining mah 2010-03-09T04:22:29Z biological_process owl:Class
GO:0033152 biolink:NamedThing immunoglobulin V(D)J recombination The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined. got7fsn_ti immunoglobulin V-D-J joining|immunoglobulin V(D)J joining|immunoglobulin V-D-J recombination|immunoglobulin V-J joining|immunoglobulin V-J recombination biological_process owl:Class
GO:1990143 biolink:NamedThing CoA-synthesizing protein complex A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway. got7fsn_ti CoA-SPC|coenzyme A-synthesizing protein complex rb 2013-07-18T22:30:20Z cellular_component owl:Class
GO:0097158 biolink:NamedThing pre-mRNA intronic pyrimidine-rich binding Binding to a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA). got7fsn_ti pre-messenger RNA intronic pyrimidine-rich binding pr 2011-09-23T11:29:03Z molecular_function owl:Class
GO:0097157 biolink:NamedThing pre-mRNA intronic binding Binding to an intronic sequence of a pre-messenger RNA (pre-mRNA). got7fsn_ti pre-messenger RNA intronic binding pr 2011-09-23T11:27:01Z molecular_function owl:Class
GO:0034845 biolink:NamedThing naphthyl-2-methyl-succinyl-CoA dehydrogenase activity Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1258|EC:1.3.99.- molecular_function owl:Class
GO:0061573 biolink:NamedThing actin filament bundle retrograde transport A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell. got7fsn_ti actin filament cable retrograde transport dph 2013-08-02T11:31:04Z biological_process owl:Class
GO:0072526 biolink:NamedThing pyridine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof. got7fsn_ti pyridine-containing compound breakdown|pyridine-containing compound catabolism|pyridine and derivative catabolic process|pyridine-containing compound degradation mah 2011-01-04T03:23:14Z biological_process owl:Class
GO:1903958 biolink:NamedThing nitric-oxide synthase complex A protein complex which is capable of nitric-oxide synthase activity. got7fsn_ti iNOS-S100A8/A9 complex An example of this is NOS2 in human (P35228) in PMID:25417112 (inferred from direct assay). bhm 2015-02-25T10:45:01Z cellular_component owl:Class
GO:2001079 biolink:NamedThing beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc binding Binding to beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc. got7fsn_ti jl 2011-09-15T01:15:19Z molecular_function owl:Class
GO:0102833 biolink:NamedThing sequoyitol galactinol:D-galactosylononitol galactosyltransferase activity Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> D-galactosylononitol + myo-inositol. got7fsn_ti MetaCyc:RXN-8292 molecular_function owl:Class
GO:0052851 biolink:NamedThing ferric-chelate reductase (NADPH) activity Catalysis of the reaction: 2 Fe3+-siderophore + NADP(+) + H(+) -> 2 Fe2+-siderophore + NADPH. got7fsn_ti ferric chelate reductase activity|iron chelate reductase activity|ferric reductase, NADPH-dependent activity https://github.com/geneontology/go-ontology/issues/21029 ai 2011-12-05T11:04:23Z KEGG_REACTION:R09541|RHEA:28795|EC:1.16.1.9|MetaCyc:RXN0-6555 molecular_function owl:Class
GO:0018453 biolink:NamedThing 2-hydroxytetrahydrofuran dehydrogenase activity Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone. got7fsn_ti UM-BBD_reactionID:r0018 molecular_function owl:Class
GO:0004027 biolink:NamedThing alcohol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate. got7fsn_ti sterol sulfokinase activity|steroid sulfokinase activity|3beta-hydroxy steroid sulfotransferase activity|alcohol/hydroxysteroid sulfotransferase activity|hydroxysteroid sulfotransferase activity|delta5-3beta-hydroxysteroid sulfokinase activity|3beta-hydroxysteroid sulfotransferase activity|3-hydroxysteroid sulfotransferase activity|dehydroepiandrosterone sulfotransferase activity|5alpha-androstenol sulfotransferase activity|estrogen sulfotransferase|3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity|steroid alcohol sulfotransferase|estrogen sulfokinase activity|alcohol sulphotransferase activity|HST|sterol sulfotransferase activity Reactome:R-HSA-176494|MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN|Reactome:R-HSA-176609|EC:2.8.2.2|RHEA:22552 molecular_function owl:Class
GO:0018168 biolink:NamedThing protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine. got7fsn_ti RESID:AA0132 biological_process owl:Class
GO:0047261 biolink:NamedThing steroid N-acetylglucosaminyltransferase activity Catalysis of the reaction: estradiol-17alpha 3-D-glucuronoside + UDP-N-acetyl-alpha-D-glucosamine = 17alpha-(N-acetyl-D-glucosaminyl)-estradiol 3-D-glucuronoside + H(+) + UDP. got7fsn_ti UDP-N-acetyl-D-glucosamine:estradiol-17alpha-3-D-glucuronoside 17alpha-N-acetylglucosaminyltransferase activity|hydroxy steroid acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-steroid acetylglucosaminyltransferase activity|steroid acetylglucosaminyltransferase activity EC:2.4.1.39|MetaCyc:2.4.1.39-RXN|RHEA:14153|KEGG_REACTION:R04451 molecular_function owl:Class
GO:0031415 biolink:NamedThing NatA complex A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins. got7fsn_ti N-terminal acetyltransferase A complex cellular_component owl:Class
GO:0002199 biolink:NamedThing zona pellucida receptor complex A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction. got7fsn_ti sperm protein complex I hjd 2011-12-23T01:33:23Z cellular_component owl:Class
GO:0019863 biolink:NamedThing IgE binding Binding to an immunoglobulin of the IgE isotype. got7fsn_ti molecular_function owl:Class
GO:0033401 biolink:NamedThing UUU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UUU codon. got7fsn_ti TTT codon-amino acid adaptor activity|phenylalanine tRNA Note that in the standard genetic code, TTT codes for phenylalanine. molecular_function owl:Class
GO:0009025 biolink:NamedThing tagatose-bisphosphate aldolase activity Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate. got7fsn_ti D-tagatose-1,6-bisphosphate triosephosphate lyase activity|AgaZ|tagatose-1,6-bisphosphate aldolase 1|KbaY|D-tagatose-1,6-bisphosphate aldolase activity|tagatose 1,6-diphosphate aldolase activity|AgaY|D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming) MetaCyc:TAGAALDOL-RXN|RHEA:22948|KEGG_REACTION:R01069|EC:4.1.2.40 molecular_function owl:Class
GO:0031883 biolink:NamedThing taste receptor binding Binding to a taste receptor. got7fsn_ti taste receptor ligand molecular_function owl:Class
GO:0016261 biolink:NamedThing selenocysteine catabolic process The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins. got7fsn_ti selenocysteine degradation|selenocysteine breakdown|selenocysteine catabolism biological_process owl:Class
GO:0044103 biolink:NamedThing L-arabinose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+. got7fsn_ti jl 2009-07-09T04:00:30Z EC:1.1.1.376 molecular_function owl:Class
GO:0071967 biolink:NamedThing lipopolysaccharide core heptosyltransferase activity Catalysis of the reaction: glucosyl-heptosyl2-KDO2-lipid A-phosphate + ADP-L-glycero-beta-D-manno-heptose = glucosyl-heptosyl3-KDO2-lipid A-phosphate + ADP + H+. got7fsn_ti LPS core heptosyltransferase activity mah 2010-10-14T05:13:31Z MetaCyc:RXN0-5122|RHEA:29923 molecular_function owl:Class
GO:0034297 biolink:NamedThing oidium formation The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus. got7fsn_ti biological_process owl:Class
GO:0103044 biolink:NamedThing ribosomal protein S6 glutamate-glutamate ligase activity Catalysis of the reaction: L-glutamate + ATP + a [protein] C-terminal L-glutamate = ADP + hydrogenphosphate + H+ + a [protein] with C-terminal alpha-L-glutamate-alpha-L-glutamate. got7fsn_ti MetaCyc:RXN0-6726 molecular_function owl:Class
GO:0018169 biolink:NamedThing ribosomal S6-glutamic acid ligase activity Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6. got7fsn_ti molecular_function owl:Class
GO:0047848 biolink:NamedThing dephospho-[reductase kinase] kinase activity Catalysis of the reaction: ATP + dephospho-[[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase] = ADP + [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase]. got7fsn_ti AMP-activated kinase activity|ATP:dephospho-{hydroxymethylglutaryl-CoA reductase (NADPH)kinase} phosphotransferase activity|AMP-activated protein kinase kinase activity|reductase kinase activity|STK30|reductase kinase kinase activity|hydroxymethylglutaryl coenzyme A reductase kinase kinase (phosphorylating) activity|dephospho-reductase kinase kinase activity|hydroxymethylglutaryl coenzyme A reductase kinase kinase activity EC:2.7.11.3|MetaCyc:DEPHOSPHO-REDUCTASE-KINASE-KINASE-RXN molecular_function owl:Class
GO:0039645 biolink:NamedThing modulation by virus of host G1/S transition checkpoint Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint. got7fsn_ti G1/S host cell cycle checkpoint dysregulation by virus bf 2012-10-09T15:08:57Z VZ:880 biological_process owl:Class
GO:0046927 biolink:NamedThing peptidyl-threonine racemization The racemization of peptidyl-L-threo-threonine at the alpha-carbon to form D-allo-threonine. This is coupled with the formation of the cross-link 2-(S-L-cysteinyl)-D-allo-threonine. got7fsn_ti biological_process owl:Class
GO:1900509 biolink:NamedThing regulation of pentose catabolic process to ethanol Any process that modulates the frequency, rate or extent of pentose catabolic process to ethanol. got7fsn_ti regulation of pentose catabolism to ethanol tt 2012-05-02T04:04:40Z biological_process owl:Class
GO:0034088 biolink:NamedThing maintenance of mitotic sister chromatid cohesion The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. got7fsn_ti mitotic cohesion stability biological_process owl:Class
GO:0034086 biolink:NamedThing maintenance of sister chromatid cohesion The process in which the association between sister chromatids of a replicated chromosome is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate. got7fsn_ti biological_process owl:Class
GO:0043727 biolink:NamedThing 5-amino-4-imidazole carboxylate lyase activity Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate. got7fsn_ti EC:4.1.1.21 molecular_function owl:Class
GO:0016260 biolink:NamedThing selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins. got7fsn_ti selenocysteine synthesis|selenocysteine biosynthesis|selenocysteine anabolism|selenocysteine formation biological_process owl:Class
GO:0080058 biolink:NamedThing protein deglutathionylation The protein modification process in which a glutathione molecule is removed from a protein amino acid by breaking a disulfide linkage. got7fsn_ti protein amino acid deglutathionylation dhl 2009-04-13T02:48:06Z biological_process owl:Class
GO:0097688 biolink:NamedThing glutamate receptor clustering The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane. got7fsn_ti glutamatergic receptor clustering pr 2015-02-11T11:49:13Z biological_process owl:Class
GO:1990005 biolink:NamedThing granular vesicle A cytoplasmic membrane-bounded vesicle of varying size, but usually larger than 45 nm, with an electron dense granular core, found in noradrenergic and peptidergic cells. got7fsn_ti pr 2012-12-11T14:51:48Z NIF_Subcellular:sao478230652 cellular_component owl:Class
GO:0061561 biolink:NamedThing trigeminal ganglion formation The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti trigeminal ganglia formation dph 2013-07-10T09:08:13Z biological_process owl:Class
GO:0070387 biolink:NamedThing procollagen-proline 4-dioxygenase complex, alpha(II) type A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type II isoform; its activity is inhibited by poly(L-proline) only at high concentrations. got7fsn_ti procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(II) type|prolyl 4-hydroxylase complex (alpha(II)-type) cellular_component owl:Class
GO:0016499 biolink:NamedThing orexin receptor activity Combining with orexin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0010206 biolink:NamedThing photosystem II repair Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition. got7fsn_ti biological_process owl:Class
GO:0030091 biolink:NamedThing protein repair The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. got7fsn_ti biological_process owl:Class
GO:0014723 biolink:NamedThing regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril. got7fsn_ti regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction biological_process owl:Class
GO:0014722 biolink:NamedThing regulation of skeletal muscle contraction by calcium ion signaling Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction. got7fsn_ti regulation of skeletal muscle contraction by calcium ion signalling biological_process owl:Class
GO:0032807 biolink:NamedThing DNA ligase IV complex A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p. got7fsn_ti DNA ligase IV-XRCC4 complex cellular_component owl:Class
GO:0071957 biolink:NamedThing old mitotic spindle pole body The spindle pole body that exists in a cell prior to spindle pole body duplication. An old spindle pole body segregates to the daughter cell upon mitosis, and lacks active proteins involved in signaling exit from mitosis. got7fsn_ti old SPB mah 2011-06-01T02:32:10Z cellular_component owl:Class
GO:0001181 biolink:NamedThing RNA polymerase I general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs. got7fsn_ti general RNA polymerase I transcription factor activity|transcription factor activity, core RNA polymerase I binding|RNA polymerase I transcription general initiation factor activity|core RNA polymerase I binding transcription factor activity https://github.com/geneontology/go-ontology/issues/20253|https://github.com/geneontology/go-ontology/issues/14736 krc 2011-08-12T04:13:30Z molecular_function owl:Class
GO:0045618 biolink:NamedThing positive regulation of keratinocyte differentiation Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation. got7fsn_ti upregulation of keratinocyte differentiation|stimulation of keratinocyte differentiation|up-regulation of keratinocyte differentiation|activation of keratinocyte differentiation|up regulation of keratinocyte differentiation biological_process owl:Class
GO:0003239 biolink:NamedThing conus arteriosus morphogenesis The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. got7fsn_ti dph 2009-10-13T11:25:04Z biological_process owl:Class
GO:0021748 biolink:NamedThing dorsal cochlear nucleus development The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0140326 biolink:NamedThing ATPase-coupled intramembrane lipid transporter activity Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases. got7fsn_ti aminophospholipid-transporting ATPase|phospholipid-translocating ATPase activity|phospholipid flippase activity|phospholipid translocating ATPase activity|phospholipid-transporting ATPase activity|ATPase-coupled phospholipid transporter activity|ATPase-dependent phospholipid transporter activity https://github.com/geneontology/go-ontology/issues/21612|https://github.com/geneontology/go-ontology/issues/17648 pg 2019-04-29T12:42:26Z GO:0008557|GO:0004012 EC:7.6.2.1|Reactome:R-HSA-939763|Reactome:R-HSA-947591|MetaCyc:3.6.3.1-RXN molecular_function owl:Class
GO:0000465 biolink:NamedThing exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0061077 biolink:NamedThing chaperone-mediated protein folding The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone. got7fsn_ti dph 2010-04-06T03:28:55Z biological_process owl:Class
GO:0019661 biolink:NamedThing glucose catabolic process to lactate via pyruvate The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP). got7fsn_ti glucose fermentation to lactate via pyruvate|homofermentative lactate fermentation|homolactic fermentation|homofermentative pathway|homofermentation|homolactate fermentation MetaCyc:ANAEROFRUCAT-PWY biological_process owl:Class
GO:0019659 biolink:NamedThing glucose catabolic process to lactate The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP). got7fsn_ti glucose fermentation to lactate|lactate fermentation Wikipedia:Lactic_acid_fermentation biological_process owl:Class
GO:0004958 biolink:NamedThing prostaglandin F receptor activity Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity. got7fsn_ti PGF receptor activity|PGF(2-alpha) receptor activity molecular_function owl:Class
GO:0044615 biolink:NamedThing nuclear pore nuclear basket A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component. got7fsn_ti jl 2012-06-20T01:31:01Z cellular_component owl:Class
GO:0070859 biolink:NamedThing positive regulation of bile acid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. got7fsn_ti upregulation of bile acid biosynthetic process|up regulation of bile acid biosynthetic process|positive regulation of bile acid synthesis|positive regulation of bile acid formation|activation of bile acid biosynthetic process|up-regulation of bile acid biosynthetic process|positive regulation of bile acid anabolism|stimulation of bile acid biosynthetic process|positive regulation of bile acid biosynthesis mah 2009-08-14T03:22:58Z biological_process owl:Class
GO:0010893 biolink:NamedThing positive regulation of steroid biosynthetic process Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. got7fsn_ti biological_process owl:Class
GO:0044028 biolink:NamedThing DNA hypomethylation An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA. got7fsn_ti biological_process owl:Class
GO:0044030 biolink:NamedThing regulation of DNA methylation Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. got7fsn_ti biological_process owl:Class
GO:0033833 biolink:NamedThing hydroxymethylfurfural reductase (NADH) activity Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+. got7fsn_ti MetaCyc:RXN-10738 molecular_function owl:Class
GO:0004781 biolink:NamedThing sulfate adenylyltransferase (ATP) activity Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. got7fsn_ti adenosine-5'-triphosphate sulfurylase activity|sulphate adenylyltransferase (ATP) activity|adenosinetriphosphate sulfurylase activity|sulfurylase activity|ATP sulfurylase activity|sulfate adenylate transferase activity|ATP:sulfate adenylyltransferase activity|ATP-sulfurylase activity|adenylylsulfate pyrophosphorylase activity EC:2.7.7.4|RHEA:18133|Reactome:R-HSA-174392|MetaCyc:SULFATE-ADENYLYLTRANS-RXN|Reactome:R-HSA-3560794 molecular_function owl:Class
GO:0010575 biolink:NamedThing positive regulation of vascular endothelial growth factor production Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor. got7fsn_ti biological_process owl:Class
GO:0071707 biolink:NamedThing immunoglobulin heavy chain V-D-J recombination The process in which immunoglobulin heavy chain V, D, and J gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). got7fsn_ti immunoglobulin V(D)J recombination|immunoglobulin V-D-J joining|immunoglobulin V(D)J joining mah 2010-03-09T04:20:31Z biological_process owl:Class
GO:0034530 biolink:NamedThing 4-hydroxymethylsalicyaldehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxymethylsalicylaldehyde + NAD+ + H2O = 4-hydroxymethylsalicylate + NADH + 2 H+. got7fsn_ti UM-BBD_reactionID:r0767|EC:1.2.1.- molecular_function owl:Class
GO:0008184 biolink:NamedThing glycogen phosphorylase activity Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate. got7fsn_ti Reactome:R-HSA-453339|Reactome:R-HSA-71515|MetaCyc:GLYCOPHOSPHORYL-RXN|Reactome:R-HSA-71590|Reactome:R-HSA-453358 molecular_function owl:Class
GO:0035272 biolink:NamedThing exocrine system development Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system. got7fsn_ti biological_process owl:Class
GO:0005117 biolink:NamedThing wishful thinking binding Binding to wishful thinking (Wit), a type II bone morphogenic protein receptor. got7fsn_ti wishful thinking ligand|Wit binding|Wit ligand|SE20 receptor binding molecular_function owl:Class
GO:0047512 biolink:NamedThing (S,S)-butanediol dehydrogenase activity Catalysis of the reaction: (S,S)-butane-2,3-diol + NAD(+) = acetoin + H(+) + NADH. got7fsn_ti L-BDH|L(+)-2,3-butanediol dehydrogenase (L-acetoin forming)|(S,S)-butane-2,3-diol:NAD+ oxidoreductase activity|L-butanediol dehydrogenase activity EC:1.1.1.76|MetaCyc:SS-BUTANEDIOL-DEHYDROGENASE-RXN|RHEA:12184|KEGG_REACTION:R03707 molecular_function owl:Class
GO:0036266 biolink:NamedThing Cdc48p-Npl4p-Vms1p AAA ATPase complex A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p. got7fsn_ti Cdc48p-Npl4p-Vms1p complex|Vms1-Cdc48-Npl4 complex|Vms1p-Cdc48p-Npl4p complex bf 2012-06-29T10:57:48Z cellular_component owl:Class
GO:0061715 biolink:NamedThing miRNA 2'-O-methylation The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an miRNA molecule. got7fsn_ti dph 2015-06-29T08:41:03Z biological_process owl:Class
GO:0062035 biolink:NamedThing sensory perception of cold stimulus The series of events required for an organism to receive a cold temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. got7fsn_ti dph 2018-04-30T13:48:10Z biological_process owl:Class
GO:0004747 biolink:NamedThing ribokinase activity Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. got7fsn_ti ATP:D-ribose 5-phosphotransferase activity|ribokinase (phosphorylating)|deoxyribokinase activity|D-ribokinase activity EC:2.7.1.15|MetaCyc:RIBOKIN-RXN|Reactome:R-HSA-8955844|RHEA:13697 molecular_function owl:Class
GO:0051285 biolink:NamedThing cell cortex of cell tip The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell. got7fsn_ti cell cortex of cell end cellular_component owl:Class
GO:0103068 biolink:NamedThing leukotriene C4 gamma-glutamyl transferase activity Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. got7fsn_ti MetaCyc:RXN66-336|EC:2.3.2.2 molecular_function owl:Class
GO:0052681 biolink:NamedThing alpha-bisabolene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,R)-alpha-bisabolene + diphosphate. got7fsn_ti bisabolene synthase activity|(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-alpha-bisabolene-forming] activity KEGG_REACTION:R08370|EC:4.2.3.38|MetaCyc:RXN-8550|RHEA:25436 molecular_function owl:Class
GO:1902102 biolink:NamedThing regulation of metaphase/anaphase transition of meiotic cell cycle Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle. got7fsn_ti regulation of meiotic metaphase/anaphase transition jl 2013-05-02T12:45:38Z biological_process owl:Class
GO:1905132 biolink:NamedThing regulation of meiotic chromosome separation Any process that modulates the frequency, rate or extent of meiotic chromosome separation. got7fsn_ti regulation of chromosome separation during meiosis|regulation of meiotic chromosome resolution dph 2016-04-12T17:46:29Z biological_process owl:Class
GO:0032492 biolink:NamedThing detection of molecule of oomycetes origin The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal. got7fsn_ti detection of oomycetes associated molecule biological_process owl:Class
GO:0003227 biolink:NamedThing right ventricular trabecular myocardium morphogenesis The process in which the anatomical structures of the right ventricular myocardium are generated and organized. got7fsn_ti dph 2009-10-13T10:50:59Z biological_process owl:Class
GO:0033116 biolink:NamedThing endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. got7fsn_ti ER-Golgi intermediate compartment membrane cellular_component owl:Class
GO:0002132 biolink:NamedThing wobble position uridine ribose methylation The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. got7fsn_ti biological_process owl:Class
GO:0101016 biolink:NamedThing FMN-binding domain binding Binding to the FMN-binding domain of a protein. got7fsn_ti molecular_function owl:Class
GO:0075293 biolink:NamedThing response to host pH environment Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the pH conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response of symbiont to host pH environment biological_process owl:Class
GO:0047781 biolink:NamedThing citrullinase activity Catalysis of the reaction: H2O + citrulline = NH3 + CO2 + L-ornithine. got7fsn_ti L-citrulline N5-carbamoyldihydrolase activity|citrulline ureidase activity|L-citrulline 5-N-carbamoyldihydrolase activity|citrulline hydrolase activity MetaCyc:CITRULLINASE-RXN|EC:3.5.1.20|RHEA:11940 molecular_function owl:Class
GO:0034790 biolink:NamedThing 3,4-dihydroxy-3,4-dihydrofluorene dehydrogenase activity Catalysis of the reaction: (+)-(3S,4R)-cis-3,4-dihydroxy-3,4-dihydrofluorene = 3,4-dihydroxyfluorene + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1043 molecular_function owl:Class
GO:0047795 biolink:NamedThing cyclohexane-1,2-diol dehydrogenase activity Catalysis of the reaction: trans-cyclohexane-1,2-diol + NAD+ = 2-hydroxycyclohexan-1-one + NADH. got7fsn_ti trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase activity MetaCyc:CYCLOHEXANE-12-DIOL-DEHYDROGENASE-RXN|EC:1.1.1.174|RHEA:18141 molecular_function owl:Class
GO:1990083 biolink:NamedThing DnaA-Hda complex A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda. got7fsn_ti bhm 2013-04-30T11:49:04Z cellular_component owl:Class
GO:0008470 biolink:NamedThing isovaleryl-CoA dehydrogenase activity Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF. got7fsn_ti isovaleroyl-coenzyme A dehydrogenase activity|3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity|3-methylbutanoyl-CoA:acceptor oxidoreductase activity|isovaleryl-coenzyme A dehydrogenase activity MetaCyc:ISOVALERYL-COA-FAD-RXN|Reactome:R-HSA-70745|RHEA:12276|EC:1.3.8.4 molecular_function owl:Class
GO:0006420 biolink:NamedThing arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0044840 biolink:NamedThing gut granule A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage. got7fsn_ti jl 2014-03-25T11:56:41Z cellular_component owl:Class
GO:0072201 biolink:NamedThing negative regulation of mesenchymal cell proliferation Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets. got7fsn_ti mah 2010-03-01T03:43:29Z biological_process owl:Class
GO:0035820 biolink:NamedThing negative regulation of renal sodium excretion by angiotensin The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time. got7fsn_ti bf 2011-04-20T02:10:50Z biological_process owl:Class
GO:0004794 biolink:NamedThing L-threonine ammonia-lyase activity Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. got7fsn_ti L-threonine hydro-lyase (deaminating) activity|L-threonine deaminase activity|L-threonine ammonia-lyase (2-oxobutanoate-forming)|threonine dehydrase activity|L-serine dehydratase activity|threonine dehydratase activity|L-threonine dehydratase activity|threonine deaminase activity|threonine ammonia-lyase activity|serine deaminase activity Note that this function was formerly EC:4.2.1.16. RHEA:22108|EC:4.3.1.19|UM-BBD_reactionID:r0433|MetaCyc:THREDEHYD-RXN molecular_function owl:Class
GO:0004069 biolink:NamedThing L-aspartate:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. got7fsn_ti aspartyl aminotransferase activity|aspartate:2-oxoglutarate aminotransferase activity|glutamic oxalic transaminase activity|aspartic acid aminotransferase activity|glutamic--aspartic transaminase activity|aspartic aminotransferase activity|L-aspartate-2-oxoglutarate aminotransferase activity|oxaloacetate-aspartate aminotransferase activity|AspT|L-aspartate transaminase activity|2-oxoglutarate-glutamate aminotransferase activity|aspartate-2-oxoglutarate transaminase activity|AAT|L-aspartate-2-oxoglutarate-transaminase activity|L-aspartic aminotransferase activity|glutamic--oxaloacetic transaminase activity|glutamic-oxalacetic transaminase activity|transaminase A activity|oxaloacetate transferase activity|L-aspartate-2-ketoglutarate aminotransferase activity|glutamate-oxalate transaminase activity|glutamic-aspartic aminotransferase activity|glutamate oxaloacetate transaminase activity|glutamate-oxalacetate aminotransferase activity|L-aspartate-alpha-ketoglutarate transaminase activity|aspartate transaminase activity|aspartate aminotransferase activity|GOT (enzyme)|aspartate alpha-ketoglutarate transaminase activity RHEA:21824|Reactome:R-HSA-70581|Reactome:R-HSA-70613|KEGG_REACTION:R00355|Reactome:R-HSA-70592|EC:2.6.1.1|Reactome:R-HSA-70596|MetaCyc:ASPAMINOTRANS-RXN molecular_function owl:Class
GO:0032496 biolink:NamedThing response to lipopolysaccharide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. got7fsn_ti response to endotoxin|response to LPS biological_process owl:Class
GO:0086074 biolink:NamedThing Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. got7fsn_ti dph 2011-11-22T10:02:24Z biological_process owl:Class
GO:0009300 biolink:NamedThing antisense RNA transcription The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA. got7fsn_ti biological_process owl:Class
GO:0022869 biolink:NamedThing protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti lactose PTS transporter activity molecular_function owl:Class
GO:0015155 biolink:NamedThing lactose transmembrane transporter activity Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. got7fsn_ti lactose/glucose efflux transporter activity|lactose permease activity GO:0019189 molecular_function owl:Class
GO:0004577 biolink:NamedThing N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol. got7fsn_ti N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity|UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity|uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity MetaCyc:2.4.1.141-RXN|EC:2.4.1.141|Reactome:R-HSA-446207|RHEA:23380|Reactome:R-HSA-5633241 molecular_function owl:Class
GO:0140272 biolink:NamedThing exogenous protein binding Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein. got7fsn_ti Note that as GO captures normal processes, it may be that exogenous proteins interactions are normal for one of the participating species but not the other. Therefore reciprocal annotations should not be made without confirming that it is physiological relevant. pg 2018-10-01T10:03:21Z molecular_function owl:Class
GO:0005608 biolink:NamedThing laminin-3 complex A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains. got7fsn_ti laminin-121 complex cellular_component owl:Class
GO:0070522 biolink:NamedThing ERCC4-ERCC1 complex A heterodimeric nucleotide-excision repair complex that has endonuclease activity specific for bubble structures characteristic of certain DNA lesions. The subunits are known as XPF/ERCC4 and ERCC1 in mammals, and Rad1p and Rad10p in S. cerevisiae. got7fsn_ti Rad1-Rad10 complex|XPF-ERCC1 complex Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. cellular_component owl:Class
GO:1990269 biolink:NamedThing RNA polymerase II C-terminal domain phosphoserine binding Binding to phosphorylated serine residues in the C-terminal domain of RNA polymerase II. got7fsn_ti RNAP II C-terminal domain phosphoserine binding|RNA Pol II C-terminal domain phosphoserine binding tb 2014-01-11T00:34:59Z molecular_function owl:Class
GO:0050815 biolink:NamedThing phosphoserine residue binding Binding to a phosphorylated serine residue within a protein. got7fsn_ti phosphoserine binding molecular_function owl:Class
GO:0047465 biolink:NamedThing N-acylglucosamine-6-phosphate 2-epimerase activity Catalysis of the reaction: N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate. got7fsn_ti N-acetylmannosamine-6-phosphate 2-epimerase activity|N-acyl-D-glucosamine-6-phosphate 2-epimerase activity|acylglucosamine-6-phosphate 2-epimerase activity|N-acetylglucosmamine 6-phosphate 2-epimerase activity|acylmannosamine phosphate 2-epimerase activity|acylglucosamine phosphate 2-epimerase activity RHEA:23932|EC:5.1.3.9|MetaCyc:5.1.3.9-RXN molecular_function owl:Class
GO:0002236 biolink:NamedThing detection of misfolded protein The series of events in which a misfolded protein stimulus is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0036020 biolink:NamedThing endolysosome membrane The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. got7fsn_ti endolysosomal membrane bf 2011-10-13T04:32:00Z cellular_component owl:Class
GO:0002154 biolink:NamedThing thyroid hormone mediated signaling pathway A series of molecular signals mediated by the detection of a thyroid hormone. got7fsn_ti thyroid hormone mediated signalling pathway hjd 2009-11-19T12:36:29Z biological_process owl:Class
GO:0034204 biolink:NamedThing lipid translocation The translocation, or flipping, of lipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. got7fsn_ti intramembrane lipid transfer biological_process owl:Class
GO:0103060 biolink:NamedThing kaempferol 3-rhamnoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol-3-rhamnoside + UDP-L-rhamnose <=> kaempferol-3-rhamnoside-7-rhamnoside + UDP. got7fsn_ti MetaCyc:RXN1F-475 molecular_function owl:Class
GO:0010904 biolink:NamedThing regulation of UDP-glucose catabolic process Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. got7fsn_ti regulation of UDP-glucose catabolism biological_process owl:Class
GO:0043558 biolink:NamedThing regulation of translational initiation in response to stress Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress. got7fsn_ti regulation of translation initiation in response to stress biological_process owl:Class
GO:0102287 biolink:NamedThing 4-coumaroylhexanoylmethane synthase activity Catalysis of the reaction: 4-coumaryl-CoA + 3-oxooctanoyl-CoA + H2O <=> 4-coumaroylhexanoylmethane + 2 coenzyme A + carbon dioxide. got7fsn_ti MetaCyc:RXN-12668 molecular_function owl:Class
GO:0031822 biolink:NamedThing type 1B serotonin receptor binding Binding to a type 1B serotonin receptor. got7fsn_ti type 1B serotonin receptor ligand|5-hydroxytryptamine 1B receptor binding molecular_function owl:Class
GO:0047949 biolink:NamedThing glutarate-semialdehyde dehydrogenase (NAD+) activity Catalysis of the reaction: glutarate semialdehyde + NAD+ + H2O = glutarate + NADH. got7fsn_ti glutarate semialdehyde dehydrogenase (NAD+) activity|glutarate-semialdehyde:NAD+ oxidoreductase activity RHEA:12064|EC:1.2.1.20|MetaCyc:GLUTARATE-SEMIALDEHYDE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0140490 biolink:NamedThing microtubule nucleator activity The action of a molecule that provides a shape mimicking the end of a microtubule to seed the formation of a new microtubule via self-assembly. got7fsn_ti microtubule nucleation template activity https://github.com/geneontology/go-ontology/issues/19709 pg 2020-07-01T08:47:54Z molecular_function owl:Class
GO:1990177 biolink:NamedThing IHF-DNA complex A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid. got7fsn_ti IHFa-IHFb-DNA complex|IHF complex bhm 2013-08-30T12:22:54Z cellular_component owl:Class
GO:0102185 biolink:NamedThing 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NADH(2-) + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) + 2 H2O. got7fsn_ti MetaCyc:RXN-11947 molecular_function owl:Class
GO:0043008 biolink:NamedThing ATP-dependent protein binding Binding to a protein or protein complex using energy from ATP hydrolysis. got7fsn_ti molecular_function owl:Class
GO:0045894 biolink:NamedThing negative regulation of mating-type specific transcription, DNA-templated Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-templated transcription. got7fsn_ti inhibition of transcription, mating-type specific|down regulation of transcription, mating-type specific|downregulation of transcription, mating-type specific|down-regulation of transcription, mating-type specific|negative regulation of mating-type specific transcription, DNA-dependent biological_process owl:Class
GO:0061520 biolink:NamedThing Langerhans cell differentiation The process in which a precursor cell type acquires the specialized features of a Langerhans cell. got7fsn_ti dph 2013-04-18T13:29:07Z biological_process owl:Class
GO:0030669 biolink:NamedThing clathrin-coated endocytic vesicle membrane The lipid bilayer surrounding a clathrin-coated endocytic vesicle. got7fsn_ti cellular_component owl:Class
GO:0061345 biolink:NamedThing planar cell polarity pathway involved in cardiac muscle cell fate commitment The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin and contributing to a cardioblast being committed to a cardiac muscle cell fate. got7fsn_ti dph 2010-09-30T12:39:05Z biological_process owl:Class
GO:0004087 biolink:NamedThing carbamoyl-phosphate synthase (ammonia) activity Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate. got7fsn_ti carbamylphosphate synthetase I|carbon-dioxide--ammonia ligase activity|carbamylphosphate synthetase activity|carbamoyl-phosphate synthetase (ammonia) activity|carbamoylphosphate synthetase (ammonia) activity|carbamoyl phosphate synthase (ammonia) activity|carbamoylphosphate synthase activity|carbamoyl-phosphate synthetase I activity|carbamoylphosphate synthase (ammonia)|carbmoylphosphate synthetase activity|carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)|CPS I activity EC:6.3.4.16|MetaCyc:6.3.4.16-RXN|Reactome:R-HSA-70555|RHEA:10624|KEGG_REACTION:R00149 molecular_function owl:Class
GO:0030265 biolink:NamedThing phospholipase C-activating rhodopsin mediated signaling pathway The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). got7fsn_ti rhodopsin mediated G-protein signalling, coupled to IP3 second messenger|rhodopsin mediated G protein signalling, coupled to IP3 second messenger|rhodopsin mediated G protein signaling, coupled to IP3 second messenger|rhodopsin mediated G-protein signaling, coupled to IP3 second messenger|phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway|PLC-activating rhodopsin mediated signaling pathway biological_process owl:Class
GO:1904967 biolink:NamedThing regulation of monopolar spindle attachment to meiosis I kinetochore Any process that modulates the frequency, rate or extent of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation. got7fsn_ti regulation of attachment of spindle microtubules to kinetochore involved in meiosis I|regulation of monopolar attachment|regulation of sister kinetochore mono-orientation|correction of merotelic kinetochore attachment, meiosis I|regulation of attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|regulation of attachment of spindle microtubules to kinetochore during meiosis I|repair of merotelic kinetochore attachment defect, meiosis I https://github.com/geneontology/go-ontology/issues/18815 mah 2016-02-15T15:19:12Z GO:0090699 biological_process owl:Class
GO:0140274 biolink:NamedThing repair of kinetochore microtubule attachment defect The cell cycle process where kinetochore microtubule attachment defects are corrected. got7fsn_ti correction of kinetochore microtubule attachment defects|repair of kinetochore microtubule attachment defects pg 2018-10-01T11:30:19Z biological_process owl:Class
GO:0047885 biolink:NamedThing farnesol 2-isomerase activity Catalysis of the reaction: 2-trans,6-trans-farnesol = 2-cis,6-trans-farnesol. got7fsn_ti 2-trans,6-trans-farnesol 2-cis-trans-isomerase activity|farnesol isomerase activity MetaCyc:FARNESOL-2-ISOMERASE-RXN|EC:5.2.1.9|KEGG_REACTION:R03265|RHEA:13401 molecular_function owl:Class
GO:0070984 biolink:NamedThing SET domain binding Binding to a SET domain of a protein. SET domains are named after three Drosophila proteins that contain this domain: Su(var), E(z) and trithorax. SET domains are associated with histone lysine methylation. got7fsn_ti SET binding mah 2009-10-27T04:09:28Z molecular_function owl:Class
GO:0003881 biolink:NamedThing CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+). got7fsn_ti CDP diglyceride-inositol phosphatidyltransferase activity|phosphatidylinositol synthase activity|cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity|CDP-diacylglycerol--inositol phosphatidyltransferase activity|CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity|CDP-DG:inositol transferase activity|CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity|CDP-diglyceride:inositol transferase activity|CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity|cytidine diphosphoglyceride-inositol transferase activity|cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity|CDP-diglyceride-inositol transferase activity|cytidine diphosphoglyceride-inositol phosphatidyltransferase activity RHEA:11580|KEGG_REACTION:R01802|MetaCyc:2.7.8.11-RXN|EC:2.7.8.11|Reactome:R-HSA-1482976 molecular_function owl:Class
GO:0047595 biolink:NamedThing 6-hydroxynicotinate reductase activity Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + oxidized ferredoxin = 6-hydroxynicotinate + reduced ferredoxin. got7fsn_ti 6-oxotetrahydronicotinate dehydrogenase activity|1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase activity|6-hydroxynicotinic reductase activity|6-oxotetrahydro-nicotinate dehydrogenase activity|6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase activity|HNA reductase activity EC:1.3.7.1|RHEA:17225|MetaCyc:6-HYDROXYNICOTINATE-REDUCTASE-RXN molecular_function owl:Class
GO:0106063 biolink:NamedThing G protein-coupled folate receptor activity Combining with folate and transmitting the signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity. got7fsn_ti G-protein coupled folate receptor activity|G-protein coupled folic acid receptor activity hjd 2017-10-27T17:10:07Z molecular_function owl:Class
GO:1902686 biolink:NamedThing mitochondrial outer membrane permeabilization involved in programmed cell death The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process. got7fsn_ti positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death|mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death|mitochondrial membrane permeability transition involved in regulated cell death|MPT involved in caspase-independent apoptosis|positive regulation of mitochondrial membrane permeability involved in PCD|mitochondrial membrane permeabilization involved in programmed cell death|MPT involved in non-apoptotic programmed cell death|mitochondrial permeability transition involved in regulated cell death|positive regulation of transport across mitochondrial membrane involved in programmed cell death|mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death|MPT involved in regulated cell death|mitochondrial membrane permeabilization involved in caspase-independent apoptosis|positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis|mitochondrial permeability transition involved in non-apoptotic programmed cell death|MPT involved in PCD|MPT involved in nonapoptotic programmed cell death|mitochondrial membrane permeability transition involved in caspase-independent apoptosis|mitochondrial membrane permeability transition involved in caspase-independent cell death|mitochondrial permeability transition involved in PCD|MPT involved in caspase-independent cell death|mitochondrion outer membrane permeabilization involved in programmed cell death|mitochondrial membrane permeabilization involved in PCD|mitochondrial membrane permeabilization involved in caspase-independent cell death|mitochondrial membrane permeability transition involved in programmed cell death|positive regulation of mitochondrial membrane permeability involved in regulated cell death|positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death|mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death|mitochondrial permeability transition involved in nonapoptotic programmed cell death|mitochondrial permeability transition involved in caspase-independent cell death|mitochondrial outer membrane permeabilization during programmed cell death|positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis|positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death|mitochondrial membrane permeability transition involved in PCD|positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death|mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death|positive regulation of transport across mitochondrial membrane involved in PCD|mitochondrial permeability transition involved in caspase-independent apoptosis|positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death|positive regulation of transport across mitochondrial membrane involved in regulated cell death|mitochondrial permeability transition involved in programmed cell death|positive regulation of mitochondrial membrane permeability involved in programmed cell death|MPT involved in programmed cell death|mitochondrial membrane permeabilization involved in regulated cell death|positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death pr 2014-02-10T12:56:34Z biological_process owl:Class
GO:0102423 biolink:NamedThing (+)-sesaminol 2-O-glucosyltransferase activity Catalysis of the reaction: (+)-sesaminol + UDP-alpha-D-glucose <=> (+)-sesaminol 2-O-beta-D-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-13818 molecular_function owl:Class
GO:0070409 biolink:NamedThing carbamoyl phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. got7fsn_ti carbamoyl phosphate anabolism|carbamoyl phosphate formation|carbamyl phosphate biosynthetic process|carbamoyl phosphate biosynthesis|carbamoyl phosphate synthesis biological_process owl:Class
GO:0061598 biolink:NamedThing molybdopterin adenylyltransferase activity Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin. got7fsn_ti dph 2014-02-10T14:14:06Z RHEA:31331|EC:2.7.7.75 molecular_function owl:Class
GO:0002152 biolink:NamedThing bile acid conjugation The process in which bile acids are covalently linked to taurine or glycine. got7fsn_ti The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine). hjd 2009-10-29T01:41:51Z biological_process owl:Class
GO:1990833 biolink:NamedThing clathrin-uncoating ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP. got7fsn_ti sl 2015-08-21T18:01:42Z molecular_function owl:Class
GO:1900565 biolink:NamedThing chanoclavine-I catabolic process The chemical reactions and pathways resulting in the breakdown of chanoclavine-I. got7fsn_ti chanoclavine-I breakdown|chanoclavine-I catabolism|chanoclavine-I degradation di 2012-05-15T06:30:48Z biological_process owl:Class
GO:0050627 biolink:NamedThing mycothione reductase activity Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione. got7fsn_ti mycothiol-disulfide reductase activity|mycothiol:NAD(P)+ oxidoreductase activity MetaCyc:1.8.1.15-RXN|EC:1.8.1.15 molecular_function owl:Class
GO:0009647 biolink:NamedThing skotomorphogenesis The control of plant growth, development, and differentiation in response to growth in darkness. got7fsn_ti etiolation biological_process owl:Class
GO:0090499 biolink:NamedThing pimelyl-[acyl-carrier protein] methyl ester esterase activity Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol. got7fsn_ti pimelyl-[acyl-carrier protein] methyl ester hydrolase activity Note that while this reaction occurs on a modified protein (acyl-carrier protein), the ACP only acts as a carrier that later releases the end product. tb 2012-10-19T12:10:01Z molecular_function owl:Class
GO:1990827 biolink:NamedThing deaminase binding Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3). got7fsn_ti sl 2015-08-19T23:48:32Z molecular_function owl:Class
GO:0086026 biolink:NamedThing atrial cardiac muscle cell to AV node cell signaling Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell. got7fsn_ti atrial cardiomyocyte to atrioventricular node cell signaling|atrial cardiomyocyte to AV node cell signalling|atrial cardiomyocyte to AV node cell signaling tb 2011-11-11T02:02:14Z biological_process owl:Class
GO:0031428 biolink:NamedThing box C/D RNP complex A ribonucleoprotein complex containing a box C/D type RNA that can carry out ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya. got7fsn_ti box C/D small nucleolar ribonucleoprotein complex|box C/D snoRNP ribose-2'-O-methyltransferase complex|box C/D snoRNP ribose 2'-O methylase complex|box C/D sRNP complex|box C/D snoRNP complex https://github.com/geneontology/go-ontology/issues/20416 cellular_component owl:Class
GO:0005732 biolink:NamedThing sno(s)RNA-containing ribonucleoprotein complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family and associated proteins. Many are involved in a step of processing of rRNA molecules: cleavage, 2'-O-methylation, or pseudouridylation, but other RNA types can be targets as well. The majority fall into one of two classes, box C/D type or box H/ACA type, which are conserved across eukaryotes and archaea. Other members include the telomerase RNA and the ribonuclease MRP RNA. got7fsn_ti small ribonucleoprotein|snoRNP|small nucleolar ribonucleoprotein complex|sRNP|small ribonucleoprotein protein complex|small nucleolar ribonucleoprotein https://github.com/geneontology/go-ontology/issues/20416 Note that 'nucleolar' in the name acronym 'snoRNA' is part of the RNA family designation 'small nucleolar', and does not reflect the location of the complex. Both box C/D type and box H/ACA RNAs are found in Archaea (where they are referred to as sRNAs) as well as in Eukaryota. In eukaryotes, box H/ACA RNAs are found in both nucleolar-localized snoRNP complexes and in Cajal body-localized scaRNP complexes. cellular_component owl:Class
GO:0036417 biolink:NamedThing tRNA destabilization Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes. got7fsn_ti bf 2013-08-22T15:43:13Z biological_process owl:Class
GO:0030474 biolink:NamedThing spindle pole body duplication Construction of a new spindle pole body. got7fsn_ti spindle pole body assembly|spindle pole body replication|spindle pole body formation|spindle pole body duplication associated with nuclear envelope|spindle pole body duplication in cytoplasm|spindle pole body biosynthesis|spindle pole body biogenesis GO:0031046|GO:0007103 biological_process owl:Class
GO:0097263 biolink:NamedThing eoxin E4 synthase activity Catalysis of the reaction: eoxin D4 + H20 = eoxin E4 + glycine. got7fsn_ti pr 2012-03-08T03:02:48Z Reactome:R-HSA-2161868 molecular_function owl:Class
GO:0035684 biolink:NamedThing helper T cell extravasation The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells. got7fsn_ti helper T-cell extravasation|T-helper cell extravasation bf 2011-02-23T01:11:05Z biological_process owl:Class
GO:0052811 biolink:NamedThing 1-phosphatidylinositol-3-phosphate 4-kinase activity Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+). got7fsn_ti phosphatidylinositol 3-phosphate 4-kinase activity|ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 4-phosphotransferase activity ai 2011-10-21T03:47:58Z RHEA:63688|Reactome:R-HSA-1676145 molecular_function owl:Class
GO:0140328 biolink:NamedThing floppase activity Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. got7fsn_ti floppase activity (cytosolic to exoplasmic leaftlet) Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the cytosolic to the exoplasmic leaftlet of a membrane). pg 2019-04-29T12:58:53Z molecular_function owl:Class
GO:0140594 biolink:NamedThing xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20814 pg 2021-02-09T18:59:49Z molecular_function owl:Class
GO:0102004 biolink:NamedThing 2-octaprenyl-6-hydroxyphenol methylase activity Catalysis of the reaction: 3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine <=> H+ + 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:2-OCTAPRENYL-6-OHPHENOL-METHY-RXN|RHEA:27770 molecular_function owl:Class
GO:0033607 biolink:NamedThing SOD1-Bcl-2 complex A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway. got7fsn_ti cellular_component owl:Class
GO:0010541 biolink:NamedThing acropetal auxin transport The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root. got7fsn_ti biological_process owl:Class
GO:0102368 biolink:NamedThing beta-amyrin 30-monooxygenase activity Catalysis of the reaction: beta-amyrin + NADPH + H+ + O2 <=> 30-hydroxy-beta-amyrin + NADP + H2O. got7fsn_ti MetaCyc:RXN-13489 molecular_function owl:Class
GO:0052684 biolink:NamedThing L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity Catalysis of the reaction: indole + L-serine = L-tryptophan + H2O. got7fsn_ti L-serine hydro-lyase (adding indole; L-tryptophan-forming) activity|tryptophan synthase beta subunit activity EC:4.2.1.122|KEGG_REACTION:R00674|MetaCyc:RXN0-2382|RHEA:26434 molecular_function owl:Class
GO:0032028 biolink:NamedThing myosin head/neck binding Binding to the head/neck region of a myosin heavy chain. got7fsn_ti molecular_function owl:Class
GO:0034353 biolink:NamedThing RNA pyrophosphohydrolase activity Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end. got7fsn_ti molecular_function owl:Class
GO:0060819 biolink:NamedThing inactivation of X chromosome by genetic imprinting Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genetic imprinting. got7fsn_ti dph 2009-08-11T10:56:06Z biological_process owl:Class
GO:0004920 biolink:NamedThing interleukin-10 receptor activity Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-10 receptor activity|IL-10R molecular_function owl:Class
GO:0045582 biolink:NamedThing positive regulation of T cell differentiation Any process that activates or increases the frequency, rate or extent of T cell differentiation. got7fsn_ti positive regulation of T-lymphocyte differentiation|up-regulation of T cell differentiation|up regulation of T cell differentiation|activation of T cell differentiation|positive regulation of T lymphocyte differentiation|positive regulation of T-cell differentiation|stimulation of T cell differentiation|positive regulation of T cell development|upregulation of T cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0006607 biolink:NamedThing NLS-bearing protein import into nucleus The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope. got7fsn_ti NLS-bearing substrate import into nucleus|NLS-bearing substrate import into cell nucleus|NLS-bearing substrate-nucleus import|NLS-bearing substrate transport from cytoplasm to nucleus biological_process owl:Class
GO:0046487 biolink:NamedThing glyoxylate metabolic process The chemical reactions and pathways involving glyoxylate, the anion of glyoxylic acid, HOC-COOH. got7fsn_ti glyoxylate metabolism biological_process owl:Class
GO:0046553 biolink:NamedThing D-malate dehydrogenase (decarboxylating) activity Catalysis of the reaction: (R)-malate + NAD(+) = CO(2) + NADH + pyruvate. got7fsn_ti (R)-malate:NAD+ oxidoreductase (decarboxylating)|D-malic enzyme|bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating)|D-malate dehydrogenase activity MetaCyc:1.1.1.83-RXN|EC:1.1.1.83|RHEA:18365|KEGG_REACTION:R00215 molecular_function owl:Class
GO:0050135 biolink:NamedThing NAD(P)+ nucleosidase activity Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide. got7fsn_ti NAD(P) nucleosidase activity|nicotinamide adenine dinucleotide (phosphate) glycohydrolase activity|triphosphopyridine nucleotidase activity|NAD(P)(+) nucleosidase activity|nicotinamide adenine dinucleotide (phosphate) nucleosidase activity|NAD(P)+ glycohydrolase activity|NAD(P)ase activity EC:3.2.2.6|MetaCyc:NADP+-NUCLEOSIDASE-RXN molecular_function owl:Class
GO:0102455 biolink:NamedThing anthocyanidin 3-O-glucoside 2''-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + an anthocyanidin-3-O-beta-D-glucoside = UDP + H+ + an anthocyanidin 3-O-sophoroside. got7fsn_ti MetaCyc:RXN-13965|RHEA:35419|EC:2.4.1.297 molecular_function owl:Class
GO:0061300 biolink:NamedThing cerebellum vasculature development The process whose specific outcome is the progression of the vasculature of the cerebellum over time, from its formation to the mature structure. got7fsn_ti dph 2010-09-06T03:36:40Z biological_process owl:Class
GO:0001944 biolink:NamedThing vasculature development The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism. got7fsn_ti vascular system development biological_process owl:Class
GO:0031388 biolink:NamedThing organic acid phosphorylation The process of introducing one or more phosphate groups into an organic acid. got7fsn_ti biological_process owl:Class
GO:0032641 biolink:NamedThing lymphotoxin A production The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A. got7fsn_ti lymphotoxin A formation|lymphotoxin A biosynthetic process|LTA production|lymphotoxin-alpha production|lymphotoxin A synthesis|tumor necrosis factor-beta production|TNF-B production|TNF-beta production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0042109 biological_process owl:Class
GO:0031604 biolink:NamedThing nuclear proteasome core complex, alpha-subunit complex The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell. got7fsn_ti cellular_component owl:Class
GO:0005680 biolink:NamedThing anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. got7fsn_ti cyclosome|anaphase promoting complex|APC Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein. Wikipedia:Anaphase-promoting_complex cellular_component owl:Class
GO:0036341 biolink:NamedThing chitin-based cuticle sclerotization by protein cross-linking The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle. got7fsn_ti chitin-based cuticle sclerotization by protein cross-linking and cuticle tanning bf 2012-09-11T13:51:46Z biological_process owl:Class
GO:0110127 biolink:NamedThing phloem unloading The process of unloading solutes that are produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues. got7fsn_ti kmv 2018-09-07T21:33:07Z biological_process owl:Class
GO:0035343 biolink:NamedThing negative regulation of inosine transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti negative regulation of hypoxanthine riboside transport bf 2010-03-04T10:06:07Z biological_process owl:Class
GO:0060970 biolink:NamedThing embryonic heart tube dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis of the embryonic heart tube are established. This process will determine the patterns of cell differentiation along the axis. got7fsn_ti dph 2009-10-06T10:14:53Z biological_process owl:Class
GO:0047881 biolink:NamedThing estradiol 17-alpha-dehydrogenase activity Catalysis of the reaction: estradiol-17-alpha + NAD(P)+ = estrone + NAD(P)H + H+. got7fsn_ti 17alpha-hydroxy steroid dehydrogenase activity|estradiol 17alpha-dehydrogenase activity|estradiol 17a-dehydrogenase activity|17alpha-hydroxysteroid oxidoreductase activity|17alpha-hydroxy steroid oxidoreductase activity|estradiol 17alpha-oxidoreductase activity|17alpha-estradiol dehydrogenase activity|17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase activity MetaCyc:ESTRADIOL-17-ALPHA-DEHYDROGENASE-RXN|EC:1.1.1.148 molecular_function owl:Class
GO:0050848 biolink:NamedThing regulation of calcium-mediated signaling Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response. got7fsn_ti regulation of calcium-mediated signalling biological_process owl:Class
GO:0021643 biolink:NamedThing vagus nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis. got7fsn_ti CN X maturation biological_process owl:Class
GO:0034807 biolink:NamedThing 4,5-dihydroxybenzo(a)pyrene methyltransferase activity Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene. got7fsn_ti UM-BBD_reactionID:r1131 molecular_function owl:Class
GO:0017095 biolink:NamedThing heparan sulfate 6-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate. got7fsn_ti heparin 6-O-sulfotransferase activity|heparan sulphate 6-O-sulphotransferase activity Reactome:R-HSA-2076419|EC:2.8.2.- molecular_function owl:Class
GO:0120258 biolink:NamedThing peptidyl-threonine O-acetylation The acetylation of peptidyl-threonine to form peptidyl-O-acetyl-L-threonine. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19957 krc 2020-09-08T18:07:44Z RESID:AA0364 biological_process owl:Class
GO:0005219 biolink:NamedThing ryanodine-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti ryanodine receptor|caffeine-sensitive calcium-release channel Reactome:R-HSA-2855020 molecular_function owl:Class
GO:0047631 biolink:NamedThing ADP-ribose diphosphatase activity Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. got7fsn_ti ADPribose diphosphatase activity|ADP-ribose ribophosphohydrolase activity|ADPribose pyrophosphatase activity|adenosine diphosphoribose pyrophosphatase activity|ADP-ribose phosphohydrolase activity|ADP-ribose pyrophosphatase activity|ADPR-PPase activity MetaCyc:RXN0-1441|Reactome:R-HSA-2393954|Reactome:R-HSA-2393939|RHEA:10412|EC:3.6.1.13|Reactome:R-HSA-5696049 molecular_function owl:Class
GO:0102297 biolink:NamedThing selenate adenylyltransferase activity Catalysis of the reaction: selenic acid + ATP + 2 H+ <=> adenylyl selenate + diphosphoric acid. got7fsn_ti MetaCyc:RXN-12720 molecular_function owl:Class
GO:0003696 biolink:NamedThing satellite DNA binding Binding to satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA. got7fsn_ti molecular_function owl:Class
GO:0060174 biolink:NamedThing limb bud formation The process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable. got7fsn_ti limbbud formation|limb formation biological_process owl:Class
GO:0047812 biolink:NamedThing D-amino-acid N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a D-amino acid = CoA + an N-acetyl-D-amino-acid. got7fsn_ti D-amino acid acetyltransferase activity|acetyl-CoA:D-amino-acid N-acetyltransferase activity|D-amino acid-alpha-N-acetyltransferase activity EC:2.3.1.36|MetaCyc:D-AMINO-ACID-N-ACETYLTRANSFERASE-RXN|RHEA:20704 molecular_function owl:Class
GO:0075261 biolink:NamedThing positive regulation of spore-bearing organ development Any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores. got7fsn_ti biological_process owl:Class
GO:0044658 biolink:NamedThing pore formation in membrane of host by symbiont The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of a host organism. got7fsn_ti jl 2012-08-01T13:14:42Z biological_process owl:Class
GO:0106271 biolink:NamedThing D-arabinose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-arabinose + NADP+ = D-arabinono-1,4-lactone + NADPH. got7fsn_ti hjd 2020-06-23T18:47:25Z RHEA:21892|EC:1.1.1.117 molecular_function owl:Class
GO:0031867 biolink:NamedThing EP4 subtype prostaglandin E2 receptor binding Binding to an EP4 subtype prostaglandin E2 receptor. got7fsn_ti prostanoid EP4 receptor binding|EP4 subtype prostaglandin E2 receptor ligand molecular_function owl:Class
GO:0042293 biolink:NamedThing Hub1 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti molecular_function owl:Class
GO:0002140 biolink:NamedThing stereocilia tip link A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia. got7fsn_ti hjd 2009-05-06T10:28:10Z cellular_component owl:Class
GO:0050042 biolink:NamedThing lactate-malate transhydrogenase activity Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate. got7fsn_ti (S)-lactate:oxaloacetate oxidoreductase activity|malate-lactate transhydrogenase activity KEGG_REACTION:R01447|RHEA:10984|EC:1.1.99.7|MetaCyc:LACTATE-MALATE-TRANSHYDROGENASE-RXN molecular_function owl:Class
GO:0090081 biolink:NamedThing regulation of heart induction by regulation of canonical Wnt signaling pathway Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes. got7fsn_ti regulation of heart induction by regulation of canonical Wnt-activated signaling pathway|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of heart induction by regulation of canonical Wnt receptor signalling pathway tb 2009-10-23T10:55:18Z biological_process owl:Class
GO:0003307 biolink:NamedThing regulation of Wnt signaling pathway involved in heart development Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time. got7fsn_ti regulation of Wnt receptor signalling pathway involved in heart development|regulation of Wnt-activated signaling pathway involved in heart development|regulation of Wnt receptor signaling pathway involved in heart development dph 2009-10-22T12:32:10Z biological_process owl:Class
GO:0102092 biolink:NamedThing 5-diphosphoinositol pentakisphosphate 3-kinase activity Catalysis of the reaction: 5-diphospho-1D-myo-inositol pentakisphosphate + ATP = 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP. got7fsn_ti EC:2.7.4.24|MetaCyc:RXN-10979 molecular_function owl:Class
GO:0071882 biolink:NamedThing phospholipase C-activating adrenergic receptor signaling pathway The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG). got7fsn_ti activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signalling pathway|adrenergic receptor, phospholipase C activating pathway mah 2010-09-13T04:32:03Z biological_process owl:Class
GO:0002556 biolink:NamedThing serotonin secretion by basophil The regulated release of serotonin by a basophil or group of basophils. got7fsn_ti serotonin release by basophil biological_process owl:Class
GO:0030399 biolink:NamedThing autophagosome membrane disassembly The controlled breakdown of the membranes of autophagosomes. got7fsn_ti autophagic vacuole membrane disassembly|autophagic membrane breakdown|autophagic membrane degradation|autophagic membrane catabolism biological_process owl:Class
GO:0061718 biolink:NamedThing glucose catabolic process to pyruvate The chemical reactions and pathways resulting in the breakdown of glucose, with the production of pyruvate. got7fsn_ti glucose catabolism to pyruvate dph 2015-06-30T13:17:26Z biological_process owl:Class
GO:0006007 biolink:NamedThing glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. got7fsn_ti glucose breakdown|glucose catabolism|glucose degradation biological_process owl:Class
GO:1990969 biolink:NamedThing modulation by host of viral RNA-binding transcription factor activity A process in which a host organism modulates the frequency, rate or extent of the activity of a viral RNA-binding transcription factor. got7fsn_ti modulation by host of viral Tat activity bf 2016-06-21T12:12:31Z biological_process owl:Class
GO:0043921 biolink:NamedThing modulation by host of viral transcription Any process in which a host organism modulates the frequency, rate or extent of viral transcription. got7fsn_ti regulation by host of viral transcription|regulation of viral transcription by host biological_process owl:Class
GO:0035875 biolink:NamedThing maintenance of meiotic sister chromatid cohesion, centromeric The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle. got7fsn_ti maintenance of centromeric meiotic sister chromatin cohesion|maintenance of sister chromatin cohesion at centromere at meiosis I|maintenance of meiotic sister chromatin cohesion at centromere bf 2011-05-31T09:35:51Z biological_process owl:Class
GO:0010432 biolink:NamedThing bract development The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. got7fsn_ti biological_process owl:Class
GO:0071247 biolink:NamedThing cellular response to chromate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chromate stimulus. got7fsn_ti mah 2009-12-03T02:46:01Z biological_process owl:Class
GO:0102468 biolink:NamedThing wogonin 7-O-glucuronosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucuronate + wogonin <=> UDP + wogonin 7-O-beta-D-glucuronate + H+. got7fsn_ti RHEA:28322|MetaCyc:RXN-14060|EC:2.4.1.253 molecular_function owl:Class
GO:0010401 biolink:NamedThing pectic galactan metabolic process The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I. got7fsn_ti pectic galactan metabolism biological_process owl:Class
GO:0010400 biolink:NamedThing rhamnogalacturonan I side chain metabolic process The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I. got7fsn_ti rhamnogalacturonan I side chain metabolism biological_process owl:Class
GO:0015274 biolink:NamedThing organellar voltage-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane. got7fsn_ti organellar voltage gated chloride channel activity|organellar voltage-dependent chloride channel activity molecular_function owl:Class
GO:0005247 biolink:NamedThing voltage-gated chloride channel activity Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage gated chloride channel activity|voltage-dependent chloride channel activity Reactome:R-HSA-2744228 molecular_function owl:Class
GO:0032505 biolink:NamedThing reproduction of a single-celled organism The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. got7fsn_ti biological_process owl:Class
GO:0010654 biolink:NamedThing apical cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote. got7fsn_ti biological_process owl:Class
GO:0062193 biolink:NamedThing D-ribose pyranase activity Catalysis of the reaction: beta-D-ribopyranose = beta-D-ribofuranose. got7fsn_ti dph 2019-12-09T16:49:07Z EC:5.4.99.62|RHEA:25432 molecular_function owl:Class
GO:0042275 biolink:NamedThing error-free postreplication DNA repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate. got7fsn_ti error-free replication restart|error-free PRR Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication. biological_process owl:Class
GO:0071586 biolink:NamedThing CAAX-box protein processing The second process in a series of specific posttranslational modifications to the CAAX box region of CAAX box proteins, in which the last three amino acids of the protein (AAX) are removed by proteolysis. got7fsn_ti mah 2010-01-28T04:42:45Z biological_process owl:Class
GO:0072359 biolink:NamedThing circulatory system development The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. got7fsn_ti cardiovascular system development mah 2010-11-16T11:27:39Z GO:0072358 biological_process owl:Class
GO:0042164 biolink:NamedThing interleukin-12 alpha subunit binding Binding to the alpha subunit of interleukin-12. got7fsn_ti IL-12p35 binding|IL-12A binding|CLMFp35 binding|NKSFp35 binding molecular_function owl:Class
GO:0019972 biolink:NamedThing interleukin-12 binding Binding to interleukin-12. got7fsn_ti IL-12 binding molecular_function owl:Class
GO:0043756 biolink:NamedThing adenosylcobinamide hydrolase activity Catalysis of the reaction: adenosylcobinamide + H(2)O = (R)-1-aminopropan-2-ol + adenosylcobyrate. got7fsn_ti adenosylcobinamide amidohydrolase activity|CbiZ|AdoCbi hydrolase activity|AdoCbi amidohydrolase activity KEGG_REACTION:R05226|EC:3.5.1.90|MetaCyc:R346-RXN|RHEA:23504 molecular_function owl:Class
GO:0021843 biolink:NamedThing substrate-independent telencephalic tangential interneuron migration The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates. got7fsn_ti biological_process owl:Class
GO:0050233 biolink:NamedThing pyranose oxidase activity Catalysis of the reaction: D-glucose + O(2) = 2-dehydro-D-glucose + H(2)O(2). got7fsn_ti glucose 2-oxidase activity|pyranose:oxygen 2-oxidoreductase activity|pyranose-2-oxidase activity KEGG_REACTION:R00302|RHEA:10552|EC:1.1.3.10|MetaCyc:PYRANOSE-OXIDASE-RXN molecular_function owl:Class
GO:0051622 biolink:NamedThing negative regulation of norepinephrine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell. got7fsn_ti downregulation of norepinephrine uptake|negative regulation of levarterenol uptake|negative regulation of noradrenaline uptake|down regulation of norepinephrine uptake|negative regulation of norepinephrine import|down-regulation of norepinephrine uptake biological_process owl:Class
GO:0009959 biolink:NamedThing negative gravitropism The orientation of plant parts away from gravity. got7fsn_ti shoot gravitropism biological_process owl:Class
GO:0102372 biolink:NamedThing alpha-amyrin 28-monooxygenase activity Catalysis of the reaction: alpha-amyrin + NADPH(4-) + O2 + H+ <=> uvaol + NADP(3-) + H2O. got7fsn_ti MetaCyc:RXN-13500 molecular_function owl:Class
GO:0034893 biolink:NamedThing N-nitrodimethylamine hydroxylase activity Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O. got7fsn_ti UM-BBD_reactionID:r1395 molecular_function owl:Class
GO:0030975 biolink:NamedThing thiamine binding Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. got7fsn_ti vitamin B1 binding|thiamin binding molecular_function owl:Class
GO:0015944 biolink:NamedThing formate oxidation The chemical reactions and pathways by which formate is converted to CO2. got7fsn_ti formic acid oxidation MetaCyc:PWY-1881 biological_process owl:Class
GO:0015942 biolink:NamedThing formate metabolic process The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. got7fsn_ti formate metabolism biological_process owl:Class
GO:0050376 biolink:NamedThing UDP-glucosamine 4-epimerase activity Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine. got7fsn_ti UDP-glucosamine epimerase activity|UDPglucosamine 4-epimerase activity RHEA:23492|MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN|EC:5.1.3.16 molecular_function owl:Class
GO:0061872 biolink:NamedThing hepatic stellate cell contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a hepatic stellate cell. got7fsn_ti dph 2017-05-01T13:25:18Z biological_process owl:Class
GO:0102633 biolink:NamedThing flaviolin monooxygenase activity Catalysis of the reaction: flaviolin-2-olate + NADH + H+ + O2 <=> mompain + NAD + H2O. got7fsn_ti MetaCyc:RXN-15585 molecular_function owl:Class
GO:0035819 biolink:NamedThing positive regulation of renal sodium excretion by pressure natriuresis An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis. got7fsn_ti natriuresis resulting from pressure natriuresis bf 2011-04-20T01:57:20Z biological_process owl:Class
GO:0009722 biolink:NamedThing detection of cytokinin stimulus The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of cytokinin stimulus biological_process owl:Class
GO:0009735 biolink:NamedThing response to cytokinin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus. got7fsn_ti response to cytokinin stimulus biological_process owl:Class
GO:0035687 biolink:NamedThing T-helper 1 cell extravasation The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. got7fsn_ti Th1 cell extravasation bf 2011-02-24T10:10:00Z biological_process owl:Class
GO:0033769 biolink:NamedThing glyceollin synthase activity Catalysis of the reactions: 2-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O, and 4-dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + NADPH + H+ + O2 = glyceollin + NADP+ + 2 H2O. got7fsn_ti 2-(or 4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan,NADPH:oxygen oxidoreductase (cyclizing) activity|dimethylallyl-3,6a,9-trihydroxypterocarpan cyclase activity MetaCyc:2.5.1.36-RXN|EC:1.14.13.85 molecular_function owl:Class
GO:0106384 biolink:NamedThing dGMP salvage Any process which produces a dGMP from derivatives of it, without de novo synthesis. got7fsn_ti hjd 2021-06-11T19:36:06Z biological_process owl:Class
GO:0072353 biolink:NamedThing cellular age-dependent response to reactive oxygen species Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. got7fsn_ti mah 2010-11-12T11:27:27Z biological_process owl:Class
GO:0001315 biolink:NamedThing age-dependent response to reactive oxygen species Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism. got7fsn_ti age-dependent response to active oxygen species|age-dependent response to ROI|age-dependent response to reactive oxidative species|age-dependent response to ROS|age-dependent response to AOS|age-dependent response to reactive oxygen intermediate biological_process owl:Class
GO:0010027 biolink:NamedThing thylakoid membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane. got7fsn_ti thylakoid membrane organization and biogenesis|thylakoid membrane organisation See also the cellular component term 'thylakoid membrane ; GO:0042651'. biological_process owl:Class
GO:0006665 biolink:NamedThing sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). got7fsn_ti sphingolipid metabolism biological_process owl:Class
GO:0006643 biolink:NamedThing membrane lipid metabolic process The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane. got7fsn_ti membrane lipid metabolism biological_process owl:Class
GO:0071968 biolink:NamedThing lipid A-core heptosyltransferase activity Catalysis of the reaction: galactosyl-glucosyl3-heptosyl3-KDO2-lipid A-bisphosphate + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H+. got7fsn_ti mah 2010-10-14T05:15:22Z MetaCyc:RXN0-5127|RHEA:30019 molecular_function owl:Class
GO:0047939 biolink:NamedThing L-glucuronate reductase activity Catalysis of the reaction: L-gulonate + NADP(+) = D-glucuronate + H(+) + NADPH. got7fsn_ti TPN-L-gulonate dehydrogenase activity|D-glucuronate reductase activity|aldehyde reductase II activity|D-glucuronate dehydrogenase activity|glucuronate dehydrogenase activity|NADP-L-gulonate dehydrogenase activity|glucuronate reductase activity Reactome:R-HSA-5661256|KEGG_REACTION:R01481|RHEA:14909|EC:1.1.1.19|MetaCyc:GLUCURONATE-REDUCTASE-RXN molecular_function owl:Class
GO:0055069 biolink:NamedThing zinc ion homeostasis Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell. got7fsn_ti zinc homeostasis biological_process owl:Class
GO:0102556 biolink:NamedThing dammarenediol 12-hydroxylase activity Catalysis of the reaction: dammarenediol-II + NADPH + H+ + O2 <=> (20S)-protopanaxadiol + NADP + H2O. got7fsn_ti EC:1.14.14.120|MetaCyc:RXN-14975|RHEA:38579 molecular_function owl:Class
GO:0086027 biolink:NamedThing AV node cell to bundle of His cell signaling Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. got7fsn_ti atrioventricular node to bundle of His cell signaling|AV node cell to bundle of His cell signalling tb 2011-11-11T02:02:14Z biological_process owl:Class
GO:0086019 biolink:NamedThing cell-cell signaling involved in cardiac conduction Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium. got7fsn_ti cell-cell signalling involved in cardiac conduction dph 2011-11-16T03:43:52Z biological_process owl:Class
GO:0036195 biolink:NamedThing muscle cell projection membrane The portion of the plasma membrane surrounding a muscle cell projection. got7fsn_ti bf 2012-04-20T10:21:51Z cellular_component owl:Class
GO:0047897 biolink:NamedThing formate-dihydrofolate ligase activity Catalysis of the reaction: 7,8-dihydrofolate + ATP + formate = 10-formyldihydrofolate + ADP + H(+) + phosphate. got7fsn_ti formyl dihydrofolate synthase activity|formate:dihydrofolate ligase (ADP-forming)|dihydrofolate formyltransferase activity MetaCyc:FORMATE--DIHYDROFOLATE-LIGASE-RXN|RHEA:24328|EC:6.3.4.17|KEGG_REACTION:R02238 molecular_function owl:Class
GO:0003051 biolink:NamedThing angiotensin-mediated drinking behavior The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst. got7fsn_ti angiotensin mediated drinking behavior biological_process owl:Class
GO:0042756 biolink:NamedThing drinking behavior The specific behavior of an organism relating to the intake of liquids, especially water. got7fsn_ti drinking behaviour biological_process owl:Class
GO:0038045 biolink:NamedThing large latent transforming growth factor-beta complex A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors. got7fsn_ti LLC|large latent complex bf 2011-11-03T04:29:49Z cellular_component owl:Class
GO:0099129 biolink:NamedThing cochlear outer hair cell electromotile response A rapid, force generating length change of an outer hair cell in response to electical stimulation. This occurs naturally as during hearing where it serves a source of mechanical amplification. got7fsn_ti biological_process owl:Class
GO:0018356 biolink:NamedThing protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine. got7fsn_ti GO:0018382 RESID:AA0258 biological_process owl:Class
GO:0044731 biolink:NamedThing Ost-alpha/Ost-beta complex A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity. got7fsn_ti Ost alpha-Ost beta complex|(Ost)2 complex|SLC51 complex jl 2012-11-06T13:42:06Z cellular_component owl:Class
GO:0099142 biolink:NamedThing intracellularly ATP-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. got7fsn_ti molecular_function owl:Class
GO:0050301 biolink:NamedThing streptomycin-6-phosphatase activity Catalysis of the reaction: H(2)O + streptomycin 6-phosphate = phosphate + streptomycin. got7fsn_ti streptomycin-6-P phosphohydrolase activity|streptomycin 6-phosphate phosphohydrolase activity|streptomycin-6-phosphate phosphohydrolase activity|streptomycin 6-phosphate phosphatase activity RHEA:10688|KEGG_REACTION:R02228|EC:3.1.3.39|MetaCyc:STREPTOMYCIN-6-PHOSPHATASE-RXN molecular_function owl:Class
GO:0035726 biolink:NamedThing common myeloid progenitor cell proliferation The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage. got7fsn_ti bf 2011-03-10T02:57:19Z biological_process owl:Class
GO:0036433 biolink:NamedThing di-trans, poly-cis-undecaprenol kinase activity Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+. got7fsn_ti ditrans,polycis-undecaprenol kinase activity bf 2013-09-16T14:21:12Z MetaCyc:UNDECAPRENOL-KINASE-RXN|RHEA:28122|KEGG_REACTION:R05626 molecular_function owl:Class
GO:0002511 biolink:NamedThing central B cell receptor editing Receptor editing occurring in B cells in the bone marrow. got7fsn_ti central B lymphocyte receptor editing|central B-cell receptor editing|central B-lymphocyte receptor editing biological_process owl:Class
GO:0060296 biolink:NamedThing regulation of cilium beat frequency involved in ciliary motility Any process that modulates the frequency of cilium beating involved in ciliary motility. got7fsn_ti biological_process owl:Class
GO:0047231 biolink:NamedThing pyridoxine 5'-O-beta-D-glucosyltransferase activity Catalysis of the reaction: pyridoxine + UDP-D-glucose = 5'-O-beta-D-glucosylpyridoxine + H(+) + UDP. got7fsn_ti UDP-glucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity|UDP-glucose:pyridoxine 5'-O-beta-glucosyltransferase activity|UDP-glucose-pyridoxine glucosyltransferase activity|UDPglucose:pyridoxine 5'-O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-pyridoxine 5'-beta-glucosyltransferase activity MetaCyc:2.4.1.160-RXN|EC:2.4.1.160|KEGG_REACTION:R01912|RHEA:20177 molecular_function owl:Class
GO:0018819 biolink:NamedThing lactoyl-CoA dehydratase activity Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O. got7fsn_ti lactoyl-CoA hydro-lyase activity|lactyl-coenzyme A dehydrase activity|lactoyl coenzyme A dehydratase activity|lactyl CoA dehydratase activity|lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)|acrylyl coenzyme A hydratase activity EC:4.2.1.54|UM-BBD_reactionID:r0086|RHEA:21056|MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN|MetaCyc:RXN-781 molecular_function owl:Class
GO:0060164 biolink:NamedThing regulation of timing of neuron differentiation The process controlling the activation and/or rate at which a relatively unspecialized cell acquires features of a neuron. got7fsn_ti biological_process owl:Class
GO:0042867 biolink:NamedThing pyruvate catabolic process The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate. got7fsn_ti pyruvate breakdown|pyruvate degradation|pyruvate catabolism biological_process owl:Class
GO:0071728 biolink:NamedThing beak development The progression of the beak over time from its initial formation until its mature state. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. got7fsn_ti mah 2010-03-17T03:52:48Z biological_process owl:Class
GO:0036488 biolink:NamedThing CHOP-C/EBP complex A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors. got7fsn_ti CHOP-C/EBP dimer|GADD153-C/EBP-alpha complex|CHOP-C/EBP heterodimer|GADD153-C/EBP complex bf 2014-11-06T13:18:49Z cellular_component owl:Class
GO:0009689 biolink:NamedThing induction of phytoalexin biosynthetic process The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection. got7fsn_ti induction of phytoalexin anabolism|induction of phytoalexin synthesis|induction of phytoalexin formation|induction of phytoalexin biosynthesis biological_process owl:Class
GO:0060757 biolink:NamedThing adult foraging behavior Behavior by which an adult locates food. got7fsn_ti dph 2009-06-22T02:50:56Z biological_process owl:Class
GO:0106264 biolink:NamedThing protein serine kinase activity (using GTP as donor) Catalysis of the reactions: GTP + L-seryl-[protein] = GDP + H(+) + O-phospho-L-seryl-[protein]. got7fsn_ti hjd 2020-05-28T18:51:18Z RHEA:64020 molecular_function owl:Class
GO:0032627 biolink:NamedThing interleukin-23 production The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-23 biosynthetic process|interleukin-23 secretion|IL-23 production GO:0042240|GO:0072621 biological_process owl:Class
GO:0045140 biolink:NamedThing inositol phosphoceramide synthase activity Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide + diacylglycerol. got7fsn_ti IPC synthase activity EC:2.7.1.227|MetaCyc:RXN3O-581 molecular_function owl:Class
GO:0004300 biolink:NamedThing enoyl-CoA hydratase activity Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O. got7fsn_ti enoyl coenzyme A hydrase (D)|crotonyl hydrase activity|unsaturated acyl-CoA hydratase activity|(3S)-3-hydroxyacyl-CoA hydro-lyase activity|short chain enoyl coenzyme A hydratase activity|2-enoyl-CoA hydratase activity|enoyl coenzyme A hydrase (L)|enol-CoA hydratase activity|hydratase, enoyl coenzyme A|short-chain enoyl-CoA hydratase activity|ECH|trans-2-enoyl-CoA hydratase activity|beta-hydroxyacid dehydrase activity|beta-hydroxyacyl-CoA dehydrase activity|D-3-hydroxyacyl-CoA dehydratase|enoyl coenzyme A hydratase activity|enoyl hydrase activity|2-octenoyl coenzyme A hydrase activity|acyl coenzyme A hydrase activity GO:0016510 EC:4.2.1.17|Reactome:R-HSA-77344|Reactome:R-HSA-77325|UM-BBD_enzymeID:e0014|Reactome:R-HSA-70830|Reactome:R-HSA-77301|Reactome:R-HSA-77277|Reactome:R-HSA-77333|Reactome:R-HSA-77314|Reactome:R-HSA-70870|RHEA:16105|MetaCyc:ENOYL-COA-HYDRAT-RXN|Reactome:R-HSA-77256 molecular_function owl:Class
GO:0098567 biolink:NamedThing periplasmic side of plasma membrane The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface. got7fsn_ti dos 2013-12-19T09:31:30Z cellular_component owl:Class
GO:0044762 biolink:NamedThing negative regulation by symbiont of host neurotransmitter secretion Any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism. got7fsn_ti jl 2012-12-06T15:52:20Z biological_process owl:Class
GO:0044079 biolink:NamedThing modulation by symbiont of host neurotransmitter secretion Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell in its host organism. got7fsn_ti modification by symbiont of host neurotransmitter secretion|regulation by symbiont of host neurotransmitter secretion|modulation of host neurotransmitter secretion by symbiont biological_process owl:Class
GO:0050057 biolink:NamedThing linamarin synthase activity Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin. got7fsn_ti UDPglucose:ketone cyanohydrin beta-glucosyltransferase activity|uridine diphosphate-glucose-ketone cyanohydrin beta-glucosyltransferase activity|uridine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity|UDPglucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity|UDP-glucose:2-hydroxy-2-methylpropanenitrile beta-D-glucosyltransferase activity|uridine diphosphoglucose-ketone glucosyltransferase activity|UDP glucose ketone cyanohydrin glucosyltransferase activity EC:2.4.1.63|MetaCyc:LINAMARIN-SYNTHASE-RXN|RHEA:20009 molecular_function owl:Class
GO:0047976 biolink:NamedThing hamamelose kinase activity Catalysis of the reaction: D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + 2 H(+). got7fsn_ti hamamelosekinase (ATP: hamamelose 2'-phosphotransferase)|hamamelose kinase (phosphorylating)|ATP/hamamelose 2'-phosphotransferase activity|ATP:D-hamamelose 2'-phosphotransferase activity MetaCyc:HAMAMELOSE-KINASE-RXN|KEGG_REACTION:R03766|RHEA:22796|EC:2.7.1.102 molecular_function owl:Class
GO:0004946 biolink:NamedThing bombesin receptor activity Combining with bombesin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0031858 biolink:NamedThing pituitary adenylate cyclase-activating polypeptide receptor binding Binding to a pituitary adenylate cyclase-activating polypeptide receptor. got7fsn_ti pituitary adenylate cyclase-activating peptide receptor ligand|pituitary adenylate cyclase activating peptide receptor binding|PACAP receptor binding molecular_function owl:Class
GO:0034542 biolink:NamedThing trimethylarsine oxidase activity Catalysis of the reaction: trimethylarsine oxide + 2 H+ + 2 e- = trimethylarsine + H2O. got7fsn_ti EC:1.97.1.-|UM-BBD_reactionID:r0807 molecular_function owl:Class
GO:0005231 biolink:NamedThing excitatory extracellular ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. got7fsn_ti Reactome:R-HSA-432164|Reactome:R-HSA-438037|Reactome:R-HSA-399712|Reactome:R-HSA-399711|Reactome:R-HSA-420980 molecular_function owl:Class
GO:0003424 biolink:NamedThing establishment of cell polarity involved in growth plate cartilage chondrocyte division The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte. got7fsn_ti growth plate cartilage chondrocyte polarization dph 2009-12-22T10:18:10Z biological_process owl:Class
GO:0140538 biolink:NamedThing negative regulation of conjugation with zygote A process that prevents a zygote from fusing an additional cell. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16329 pg 2020-11-07T07:50:23Z biological_process owl:Class
GO:0031138 biolink:NamedThing negative regulation of conjugation with cellular fusion Any process that decreases the rate or frequency of conjugation with cellular fusion. got7fsn_ti down regulation of conjugation with cellular fusion|inhibition of conjugation with cellular fusion|downregulation of conjugation with cellular fusion|down-regulation of conjugation with cellular fusion biological_process owl:Class
GO:0075003 biolink:NamedThing adhesion of symbiont appressorium to host The attachment of an appressorium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti adhesion of symbiont appressorium to host during symbiotic interaction https://github.com/geneontology/go-ontology/issues/21505 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0047635 biolink:NamedThing alanine-oxo-acid transaminase activity Catalysis of the reaction: L-alanine + a 2-oxo acid = pyruvate + an L-amino acid. got7fsn_ti L-alanine:2-oxo-acid aminotransferase activity|alanine--oxo-acid aminotransferase activity|alanine-keto acid aminotransferase activity|leucine-alanine transaminase activity|alanine-oxo acid aminotransferase activity|L-alanine-alpha-keto acid aminotransferase activity|alanine-oxo-acid aminotransferase activity EC:2.6.1.12|RHEA:19953|MetaCyc:ALANINE--OXO-ACID-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:0080140 biolink:NamedThing regulation of jasmonic acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving jasmonic acid. got7fsn_ti dhl 2009-05-19T04:24:55Z biological_process owl:Class
GO:0019217 biolink:NamedThing regulation of fatty acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. got7fsn_ti regulation of fatty acid metabolism GO:0006632 biological_process owl:Class
GO:0043014 biolink:NamedThing alpha-tubulin binding Binding to the microtubule constituent protein alpha-tubulin. got7fsn_ti alpha tubulin binding molecular_function owl:Class
GO:0070486 biolink:NamedThing leukocyte aggregation The adhesion of one leukocyte to one or more other leukocytes via adhesion molecules. got7fsn_ti immune cell aggregation|leucocyte aggregation|white blood cell aggregation|white corpuscle aggregation biological_process owl:Class
GO:0090523 biolink:NamedThing cytochrome-b5 reductase activity, acting on NADPH Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5). got7fsn_ti cytochrome-b5 reductase activity tb 2013-01-11T12:21:41Z RHEA:64576 molecular_function owl:Class
GO:0016041 biolink:NamedThing glutamate synthase (ferredoxin) activity Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. got7fsn_ti L-glutamate:ferredoxin oxidoreductase (transaminating)|glutamate synthase (ferredoxin-dependent)|ferredoxin-glutamate synthase activity|ferredoxin-dependent glutamate synthase activity MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN|EC:1.4.7.1|MetaCyc:PWY-4341|RHEA:12128 molecular_function owl:Class
GO:0036193 biolink:NamedThing 2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O. got7fsn_ti bf 2012-04-19T11:54:34Z EC:1.14.14.110|RHEA:31939|KEGG_REACTION:R07423 molecular_function owl:Class
GO:0004130 biolink:NamedThing cytochrome-c peroxidase activity Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O. got7fsn_ti apocytochrome c peroxidase activity|cytochrome c-H2O oxidoreductase activity|cytochrome c peroxidase activity|mesocytochrome c peroxidase azide|cytochrome peroxidase activity|cytochrome c-551 peroxidase activity|mesocytochrome c peroxidase cyanide|mesocytochrome c peroxidase cyanate|ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity EC:1.11.1.5|MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN|RHEA:16581 molecular_function owl:Class
GO:0030294 biolink:NamedThing receptor signaling protein tyrosine kinase inhibitor activity Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase. got7fsn_ti receptor signalling protein tyrosine kinase inhibitor activity molecular_function owl:Class
GO:0030292 biolink:NamedThing protein tyrosine kinase inhibitor activity Stops, prevents or reduces the activity of a protein tyrosine kinase. got7fsn_ti molecular_function owl:Class
GO:0032249 biolink:NamedThing regulation of adenosine transport Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0036110 biolink:NamedThing cellular response to inositol starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol. got7fsn_ti bf 2012-02-15T10:46:07Z biological_process owl:Class
GO:0030108 biolink:NamedThing HLA-A specific activating MHC class I receptor activity Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte. got7fsn_ti molecular_function owl:Class
GO:0032397 biolink:NamedThing activating MHC class I receptor activity Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte. got7fsn_ti molecular_function owl:Class
GO:0032841 biolink:NamedThing calcitonin binding Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid. got7fsn_ti molecular_function owl:Class
GO:0097737 biolink:NamedThing acquisition of mycelium reproductive competence A maturation process by which an organism acquires the ability to reproduce. In fungi, reproductive competence only occurs in a population of filamentous cells that form a mycelium. got7fsn_ti mycelium developmental competence pr 2016-10-14T16:36:09Z biological_process owl:Class
GO:0047427 biolink:NamedThing cyanoalanine nitrilase activity Catalysis of the reaction: 3-cyano-L-alanine + 2 H(2)O + H(+) = L-aspartate + NH(4)(+). got7fsn_ti 3-cyano-L-alanine aminohydrolase activity|beta-cyanoalanine nitrilase activity EC:3.5.5.4|MetaCyc:3.5.5.4-RXN|RHEA:11188|KEGG_REACTION:R00486 molecular_function owl:Class
GO:0014845 biolink:NamedThing stomach body smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined. got7fsn_ti biological_process owl:Class
GO:0014828 biolink:NamedThing distal stomach smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus. got7fsn_ti biological_process owl:Class
GO:1904606 biolink:NamedThing fat cell apoptotic process Any apoptotic process in a fat cell. got7fsn_ti adipose cell apoptotic process|adipocyte apoptotic process|adipose cell apoptosis|fat cell apoptosis|adipocyte apoptosis sl 2015-08-27T18:13:06Z biological_process owl:Class
GO:0050211 biolink:NamedThing procollagen galactosyltransferase activity Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine. got7fsn_ti uridine diphosphogalactose-collagen galactosyltransferase activity|collagen hydroxylysyl galactosyltransferase activity|collagen galactosyltransferase activity|UDPgalactose:5-hydroxylysine-collagen galactosyltransferase activity|UDP galactose-collagen galactosyltransferase activity|hydroxylysine galactosyltransferase activity|UDP-galactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity|UDPgalactose:procollagen-5-hydroxy-L-lysine D-galactosyltransferase activity MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN|RHEA:12637|Reactome:R-HSA-1981128|Reactome:R-HSA-1981120|EC:2.4.1.50 molecular_function owl:Class
GO:0046488 biolink:NamedThing phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. got7fsn_ti PtdIns metabolic process|phosphoinositide metabolic process|phosphatidylinositol metabolism|PtdIns metabolism|phosphoinositide metabolism GO:0030384 biological_process owl:Class
GO:0050575 biolink:NamedThing 2-(S)-hydroxypropyl-CoM dehydrogenase activity Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH. got7fsn_ti 2-[2-(S)-hydroxypropylthio]ethanesulfonate:NAD+ oxidoreductase activity|2-(2-(S)-hydroxypropylthio)ethanesulfonate dehydrogenase activity KEGG_REACTION:R05690|RHEA:21052|EC:1.1.1.269|UM-BBD_reactionID:r0853|MetaCyc:1.1.1.269-RXN molecular_function owl:Class
GO:0003090 biolink:NamedThing positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings. got7fsn_ti positive regulation of heart contraction by epinephrine-norepinephrine|positive regulation of heart contraction by adrenaline-noradrenaline|increased force of heart contraction by neuronal adrenaline-noradrenaline|increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings|increased force of heart contraction by neuronal epinephrine-norepinephrine biological_process owl:Class
GO:0034965 biolink:NamedThing intronic box C/D RNA processing Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA. got7fsn_ti intronic box C/D snoRNA processing|intronic box C/D sRNA processing biological_process owl:Class
GO:0031070 biolink:NamedThing intronic snoRNA processing The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA. got7fsn_ti biological_process owl:Class
GO:0002538 biolink:NamedThing arachidonic acid metabolite production involved in inflammatory response The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels. got7fsn_ti production of arachidonic acid metabolites involved in acute inflammatory response|arachidonic acid metabolite production involved in acute inflammatory response|production of arachidonic acid metabolites involved in inflammatory response biological_process owl:Class
GO:0099091 biolink:NamedThing postsynaptic specialization, intracellular component A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. got7fsn_ti cellular_component owl:Class
GO:0140649 biolink:NamedThing cell-to-cell migration by invasive hypha The directional movement of a hyphal filament from one host cell to another. This process involves the clearance of plant-derived plasmodesmal occlusion materials, cytoskeleton based constriction of invasive hypha to traverse plasmodesmata. Septins and F-actin are reorganized into an hourglass shape at the point of maximum hyphal constriction. got7fsn_ti plant tissue colonization|host tissue colonization|invasive growth|invasive hyphae formation https://github.com/geneontology/go-ontology/issues/21125 Do not confuse with ' GO:0036267 invasive filamentous growth ', which doesn't include invasion of cells within the host. pg 2021-05-25T07:42:38Z biological_process owl:Class
GO:0052717 biolink:NamedThing tRNA-specific adenosine-34 deaminase activity Catalysis of the reaction: adenosine-34 + H2O = inosine-34 + NH3, in a tRNA-Ala molecule. got7fsn_ti tRNA(Ala)-A34 deaminase activity ai 2011-08-12T11:48:54Z molecular_function owl:Class
GO:0008064 biolink:NamedThing regulation of actin polymerization or depolymerization Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. got7fsn_ti biological_process owl:Class
GO:0001156 biolink:NamedThing TFIIIC-class transcription factor complex binding Binding to a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III. got7fsn_ti TFIIIC-class transcription factor binding krc 2011-01-27T05:02:22Z molecular_function owl:Class
GO:0009051 biolink:NamedThing pentose-phosphate shunt, oxidative branch The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2). got7fsn_ti oxidative branch, pentose pathway|pentose phosphate pathway, oxidative branch|pentose-phosphate pathway, oxidative branch|pentose phosphate shunt, oxidative branch|oxidative pentose phosphate pathway MetaCyc:OXIDATIVEPENT-PWY biological_process owl:Class
GO:0120105 biolink:NamedThing mitotic actomyosin contractile ring, intermediate layer The region of the mitotic actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer. got7fsn_ti actomyosin contractile ring, intermediate layer krc 2017-10-11T22:54:40Z cellular_component owl:Class
GO:0006009 biolink:NamedThing glucose 1-phosphate phosphorylation The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate. got7fsn_ti biological_process owl:Class
GO:0034323 biolink:NamedThing O-butanoyltransferase activity Catalysis of the transfer of a butyl group to an oxygen atom on the acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0003196 biolink:NamedThing ventriculo bulbo valve formation The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti dph 2009-10-08T01:16:02Z biological_process owl:Class
GO:0005459 biolink:NamedThing UDP-galactose transmembrane transporter activity Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate. got7fsn_ti Reactome:R-HSA-735702|Reactome:R-HSA-5652099 molecular_function owl:Class
GO:0042014 biolink:NamedThing interleukin-19 receptor activity Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-19R|IL-19 receptor activity molecular_function owl:Class
GO:0030598 biolink:NamedThing rRNA N-glycosylase activity Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species. got7fsn_ti rRNA N-glycohydrolase activity|mirabilis antiviral protein|saporins|rRNA N-glycosidase activity|ricin|ribosomal ribonucleate N-glycosidase activity|gelonin|momorcochin-S|nigrin b|RNA N-glycosidase activity MetaCyc:3.2.2.22-RXN|EC:3.2.2.22 molecular_function owl:Class
GO:0030597 biolink:NamedThing RNA glycosylase activity Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule. got7fsn_ti molecular_function owl:Class
GO:0039540 biolink:NamedThing suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. got7fsn_ti suppression by virus of host RIG-I signaling pathway|suppression by virus of host RIG-I activity|inhibition by virus of host RIG-I|inhibition by virus of host DDX58 activity|inhibition of host DDX58/RIG-I by virus|suppression by virus of host DDX58 signaling pathway|inhibition by virus of host RIG-I signaling|suppression by virus of host RIG-I signalling pathway https://github.com/geneontology/go-ontology/issues/21984 This term is for annotation of viral proteins that counteract the host anti-viral innate immune response initiated by host RIG-I, either by binding and inhibiting host RIG-I directly, or by interfering with other processes so that RIG-I is unable to carry out its normal function (e.g. by processing viral RNA so it cannot be recognized by RIG-I, or by promoting the degradation of RIG-I). bf 2012-01-18T02:24:20Z GO:0039538 biological_process owl:Class
GO:0008829 biolink:NamedThing dCTP deaminase activity Catalysis of the reaction: dCTP + H2O = dUTP + NH3. got7fsn_ti deoxycytidine triphosphate deaminase activity|5-methyl-dCTP deaminase activity|dCTP aminohydrolase activity MetaCyc:DCTP-DEAM-RXN|EC:3.5.4.13|RHEA:22680|Reactome:R-HSA-180632 molecular_function owl:Class
GO:0047150 biolink:NamedThing betaine-homocysteine S-methyltransferase activity Catalysis of the reaction: L-homocysteine + betaine = N,N-dimethylglycine + L-methionine. got7fsn_ti trimethylammonioacetate:L-homocysteine S-methyltransferase activity|betaine-homocysteine transmethylase activity|betaine-homocysteine methyltransferase activity Reactome:R-HSA-1614654|EC:2.1.1.5|RHEA:22336|KEGG_REACTION:R02821|MetaCyc:2.1.1.5-RXN molecular_function owl:Class
GO:0102074 biolink:NamedThing OPC6-trans-2-enoyl-CoA hydratase activity Catalysis of the reaction: OPC6-3-hydroxyacyl-CoA <=> OPC6-trans-2-enoyl-CoA + H2O. got7fsn_ti MetaCyc:RXN-10704 molecular_function owl:Class
GO:0050968 biolink:NamedThing detection of chemical stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal. got7fsn_ti perception of pain, sensory detection of chemical stimulus|chemical nociception|sensory detection of chemical stimulus during perception of pain|perception of pain, detection of chemical stimulus|sensory transduction of chemical stimulus during perception of pain|perception of pain, sensory transduction of chemical stimulus biological_process owl:Class
GO:0004161 biolink:NamedThing dimethylallyltranstransferase activity Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. got7fsn_ti geranyl pyrophosphate synthase activity|trans-farnesyl pyrophosphate synthetase activity|geranyl-diphosphate synthase activity|dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity|geranyl pyrophosphate synthetase activity|DMAPP:IPP-dimethylallyltransferase activity|(2E,6E)-farnesyl diphosphate synthetase activity|geranyl diphosphate synthase|dimethylallyltransferase activity|diprenyltransferase activity Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. MetaCyc:GPPSYN-RXN|RHEA:22408|EC:2.5.1.1|Reactome:R-HSA-191322 molecular_function owl:Class
GO:0002564 biolink:NamedThing alternate splicing of immunoglobulin genes The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons. got7fsn_ti alternate splicing of antibody genes biological_process owl:Class
GO:0061406 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose. got7fsn_ti dph 2012-01-12T11:16:10Z biological_process owl:Class
GO:0008478 biolink:NamedThing pyridoxal kinase activity Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. got7fsn_ti vitamin B(6) kinase activity|pyridoxal phosphokinase activity|pyridoxal 5-phosphate-kinase activity|vitamin B6 kinase activity|pyridoxal kinase (phosphorylating)|ATP:pyridoxal 5'-phosphotransferase activity|pyridoxamine kinase activity|pyridoxine kinase activity RHEA:10224|MetaCyc:PYRIDOXKIN-RXN|Reactome:R-HSA-964962|Reactome:R-HSA-964970|Reactome:R-HSA-964958|EC:2.7.1.35 molecular_function owl:Class
GO:0060944 biolink:NamedThing neural crest-derived cardiac fibroblast cell fate commitment The commitment of neural crest cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T02:42:39Z biological_process owl:Class
GO:0060937 biolink:NamedThing cardiac fibroblast cell fate commitment The commitment of cells to a cardiac fibroblast fate and their capacity to differentiate into cardiac fibroblast cells. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T01:24:59Z biological_process owl:Class
GO:0008675 biolink:NamedThing 2-dehydro-3-deoxy-phosphogluconate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate. got7fsn_ti 2-keto-3-deoxy-6-phosphogluconate aldolase activity|KDPG aldolase activity|phospho-2-dehydro-3-deoxygluconate aldolase activity|ODPG aldolase activity|6-phospho-2-keto-3-deoxygluconate aldolase activity|2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)|KDPG-aldolase activity|2-keto-3-deoxygluconate-6-P-aldolase activity|2-keto-3-deoxy-6-phosphogluconic aldolase activity|2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity|2-keto-3-deoxygluconate-6-phosphate aldolase activity|2-oxo-3-deoxy-6-phosphogluconate aldolase activity|phospho-2-keto-3-deoxygluconic aldolase activity|phospho-2-keto-3-deoxygluconate aldolase activity EC:4.1.2.14|MetaCyc:KDPGALDOL-RXN|RHEA:17089 molecular_function owl:Class
GO:0015369 biolink:NamedThing calcium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in). got7fsn_ti calcium:hydrogen antiporter activity Reactome:R-HSA-8949687|RHEA:29671 molecular_function owl:Class
GO:0015368 biolink:NamedThing calcium:cation antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). got7fsn_ti Reactome:R-HSA-425822 molecular_function owl:Class
GO:0070928 biolink:NamedThing regulation of mRNA stability, ncRNA-mediated Any process, mediated by small non-coding RNAs, that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. got7fsn_ti regulation of mRNA stability, non-coding RNA-mediated|ncRNA-mediated regulation of mRNA stability mah 2009-09-16T03:26:21Z biological_process owl:Class
GO:0047282 biolink:NamedThing dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity Catalysis of the reaction: dTDP-L-dihydrostreptose + streptidine 6-phosphate = O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate + dTDP + H(+). got7fsn_ti thymidine diphosphodihydrostreptose-streptidine 6-phosphate dihydrostreptosyltransferase activity|dTDPdihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity|dTDP-L-dihydrostreptose:streptidine-6-phosphate dihydrostreptosyltransferase activity RHEA:24392|KEGG_REACTION:R04222|MetaCyc:2.4.2.27-RXN|EC:2.4.2.27 molecular_function owl:Class
GO:0005818 biolink:NamedThing aster An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores. got7fsn_ti cellular_component owl:Class
GO:0019061 biolink:NamedThing uncoating of virus The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome. got7fsn_ti viral uncoating biological_process owl:Class
GO:0009523 biolink:NamedThing photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. got7fsn_ti Wikipedia:Photosystem_II cellular_component owl:Class
GO:0045169 biolink:NamedThing fusome A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle. got7fsn_ti cellular_component owl:Class
GO:0017075 biolink:NamedThing syntaxin-1 binding Binding to a syntaxin-1 SNAP receptor. got7fsn_ti molecular_function owl:Class
GO:0004352 biolink:NamedThing glutamate dehydrogenase (NAD+) activity Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. got7fsn_ti NAD-specific glutamic dehydrogenase activity|NAD-dependent glutamate dehydrogenase activity|NAD:glutamate oxidoreductase activity|NAD-dependent glutamic dehydrogenase activity|NAD-glutamate dehydrogenase activity|glutamic acid dehydrogenase|L-glutamate dehydrogenase|glutamate dehydrogenase (NAD)|glutamate oxidoreductase activity|L-glutamate:NAD+ oxidoreductase (deaminating)|NAD-specific glutamate dehydrogenase activity|NADH-linked glutamate dehydrogenase activity|NAD-linked glutamic dehydrogenase activity|glutamic dehydrogenase activity|NAD-linked glutamate dehydrogenase activity RHEA:15133|MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN|EC:1.4.1.2 molecular_function owl:Class
GO:0001110 biolink:NamedThing promoter clearance from RNA polymerase III promoter Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase. got7fsn_ti krc 2010-12-01T03:08:29Z biological_process owl:Class
GO:0009745 biolink:NamedThing sucrose mediated signaling A series of molecular signals mediated by the detection of sucrose. got7fsn_ti sucrose mediated signalling biological_process owl:Class
GO:0034162 biolink:NamedThing toll-like receptor 9 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 9. got7fsn_ti toll-like receptor 9 signalling pathway|TLR9 signaling pathway biological_process owl:Class
GO:0007621 biolink:NamedThing negative regulation of female receptivity Any process that stops, prevents or reduces the receptiveness of a female to male advances. got7fsn_ti inhibition of female receptivity|down-regulation of female receptivity|downregulation of female receptivity|down regulation of female receptivity biological_process owl:Class
GO:0052367 biolink:NamedThing disruption by host of symbiont cellular component The chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti degradation of symbiont cellular component by organism|disassembly by host of symbiont cellular component|catabolism of symbiont structural constituent by organism|catabolism of symbiont cellular component by organism biological_process owl:Class
GO:0018280 biolink:NamedThing protein S-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine. got7fsn_ti protein amino acid S-linked glycosylation biological_process owl:Class
GO:0047176 biolink:NamedThing beta-glucogallin-tetrakisgalloylglucose O-galloyltransferase activity Catalysis of the reaction: 1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose. got7fsn_ti 1-O-galloyl-beta-D-glucose:1,2,3,6-tetrakis-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity|beta-glucogallin:1,2,3,6-tetra-O-galloylglucose 4-O-galloyltransferase activity|beta-glucogallin-tetragalloylglucose 4-galloyltransferase activity|beta-glucogallin:1,2,3,6-tetra-O-galloyl-beta-D-glucose 4-O-galloyltransferase activity EC:2.3.1.143|RHEA:19109|KEGG_REACTION:R04498|MetaCyc:2.3.1.143-RXN molecular_function owl:Class
GO:1990089 biolink:NamedThing response to nerve growth factor A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. got7fsn_ti response to nerve growth factor stimulus sl 2013-05-06T17:08:47Z biological_process owl:Class
GO:0098610 biolink:NamedThing adhesion between unicellular organisms The attachment of two unicellular organisms to each other. got7fsn_ti multi-organismal cell-cell adhesion|adhesion between unicellular organisms via cell-wall interaction https://github.com/geneontology/go-ontology/issues/18814 GO:0098741 biological_process owl:Class
GO:0047686 biolink:NamedThing arylsulfate sulfotransferase activity Catalysis of the reaction: an aryl sulfate + a phenol = a phenol + an aryl sulfate. got7fsn_ti arylsulfate:phenol sulfotransferase activity|ASST|arylsulfate-phenol sulfotransferase activity|arylsulphate sulphotransferase activity|arylsulfotransferase RHEA:51072|EC:2.8.2.22|MetaCyc:ARYLSULFATE-SULFOTRANSFERASE-RXN molecular_function owl:Class
GO:0099638 biolink:NamedThing endosome to plasma membrane protein transport The directed movement of proteins from the endosome to the plasma membrane in transport vesicles. got7fsn_ti biological_process owl:Class
GO:0090151 biolink:NamedThing establishment of protein localization to mitochondrial membrane The directed movement of a protein to a specific location in the mitochondrial membrane. got7fsn_ti establishment of protein localization in mitochondrial membrane|establishment of protein localisation in mitochondrial membrane tb 2009-12-08T03:18:51Z biological_process owl:Class
GO:0000455 biolink:NamedThing enzyme-directed rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA. got7fsn_ti biological_process owl:Class
GO:0070789 biolink:NamedThing metula development The process whose specific outcome is the progression of metulae over time, from its formation to the mature structure. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. got7fsn_ti development of primary sterigmata mah 2009-07-08T01:33:46Z biological_process owl:Class
GO:0003325 biolink:NamedThing pancreatic PP cell development The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. got7fsn_ti dph 2009-11-02T08:25:03Z biological_process owl:Class
GO:0005133 biolink:NamedThing interferon-gamma receptor binding Binding to an interferon-gamma receptor. got7fsn_ti interferon-gamma receptor ligand|interferon-gamma molecular_function owl:Class
GO:0047600 biolink:NamedThing abequosyltransferase activity Catalysis of the reaction: CDP-abequose + D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid = CDP + D-abequosyl-D-mannosyl-rhamnosyl-D-galactose-1-diphospholipid. got7fsn_ti CDP-abequose:D-mannosyl-L-rhamnosyl-D-galactose-1-diphospholipid D-abequosyltransferase activity|trihexose diphospholipid abequosyltransferase activity RHEA:34183|EC:2.4.1.60|MetaCyc:ABEQUOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0036053 biolink:NamedThing glomerular endothelium fenestra A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes. got7fsn_ti GEnC fenestration|glomerular endothelial cell fenestration bf 2011-12-12T10:53:24Z cellular_component owl:Class
GO:0006613 biolink:NamedThing cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria. got7fsn_ti cotranslational membrane targeting|cotranslational protein-membrane targeting|cotranslational protein membrane targeting biological_process owl:Class
GO:0008681 biolink:NamedThing 2-octaprenyl-6-methoxyphenol hydroxylase activity Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O. got7fsn_ti RHEA:29407|MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN molecular_function owl:Class
GO:0003836 biolink:NamedThing beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. got7fsn_ti CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity|CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity Reactome:R-HSA-1912378|RHEA:21616|Reactome:R-HSA-9605600|Reactome:R-HSA-981497|Reactome:R-HSA-9603987|EC:2.4.99.4|Reactome:R-HSA-2046285|Reactome:R-HSA-4084984|MetaCyc:2.4.99.4-RXN|Reactome:R-HSA-3656258|Reactome:R-HSA-1022129 molecular_function owl:Class
GO:0033727 biolink:NamedThing aldehyde dehydrogenase (FAD-independent) activity Catalysis of the reaction: an aldehyde + H2O + acceptor = a carboxylate + reduced acceptor. got7fsn_ti AORDd|aldehyde:acceptor oxidoreductase (FAD-independent) activity|Mop|aldehyde oxidoreductase activity EC:1.2.99.7|MetaCyc:1.2.99.3-RXN|MetaCyc:1.2.99.7-RXN|MetaCyc:CARBOXYLATE-REDUCTASE-RXN molecular_function owl:Class
GO:0050011 biolink:NamedThing itaconyl-CoA hydratase activity Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O. got7fsn_ti itaconyl coenzyme A hydratase activity|citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)|citramalyl-CoA hydro-lyase activity EC:4.2.1.56|MetaCyc:ITACONYL-COA-HYDRATASE-RXN|RHEA:13785 molecular_function owl:Class
GO:0050889 biolink:NamedThing determination of stimulus intensity The determination of the perceived strength of a sensory stimulus. got7fsn_ti biological_process owl:Class
GO:0000246 biolink:NamedThing delta24(24-1) sterol reductase activity Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH. got7fsn_ti C-24(28) sterol reductase activity|sterol delta-24(28) methylene reductase activity|sterol delta24(28)-reductase activity|sterol Delta(24(28))-reductase activity|ergosterol:NADP+ delta24(241)-oxidoreductase activity|sterol delta-24(28) reductase activity|sterol Delta(24(28))-methylene reductase activity|delta24(241)-sterol reductase activity|D24(24-1)-sterol reductase activity|sterol delta24(28)-methylene reductase activity MetaCyc:1.3.1.71-RXN|RHEA:18501|KEGG_REACTION:R05641|EC:1.3.1.71 molecular_function owl:Class
GO:0044600 biolink:NamedThing protein guanylyltransferase activity Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins. got7fsn_ti jl 2012-05-01T04:00:34Z molecular_function owl:Class
GO:0070285 biolink:NamedThing pigment cell development The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate. got7fsn_ti biological_process owl:Class
GO:0047994 biolink:NamedThing hydroxymethylglutaryl-CoA hydrolase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA + H(2)O = 3-hydroxy-3-methylglutarate + CoA + H(+). got7fsn_ti beta-hydroxy-beta-methylglutaryl coenzyme A deacylase activity|beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase activity|(S)-3-hydroxy-3-methylglutaryl-CoA hydrolase activity|hydroxymethylglutaryl coenzyme A deacylase activity|hydroxymethylglutaryl coenzyme A hydrolase activity|3-hydroxy-3-methylglutaryl-CoA hydrolase activity EC:3.1.2.5|KEGG_REACTION:R02083|MetaCyc:HYDROXYMETHYLGLUTARYL-COA-HYDROLASE-RXN|RHEA:16305 molecular_function owl:Class
GO:0047444 biolink:NamedThing N-acylneuraminate-9-phosphate synthase activity Catalysis of the reaction: H2O + phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate = phosphate + N-acylneuraminate 9-phosphate. got7fsn_ti N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase activity|N-acetylneuraminate 9-phosphate lyase activity|phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase activity|N-acetylneuraminic acid phosphate synthase activity|N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating) activity|sialic acid 9-phosphate synthetase activity|N-acetylneuraminate 9-phosphate synthetase activity GO:0019007 MetaCyc:4.1.3.20-RXN|EC:2.5.1.57|RHEA:13421|Reactome:R-HSA-4084976 molecular_function owl:Class
GO:0043082 biolink:NamedThing megagametophyte egg cell nucleus The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo. got7fsn_ti cellular_component owl:Class
GO:0098832 biolink:NamedThing peri-centrosomal recycling endosome A recycling endosome that is organized around the microtubule organizing center, close to the nucleus. This is the main recycling endosome of most cells. It receives input from the Golgi as well as recycled molecules from early endosomes. got7fsn_ti cellular_component owl:Class
GO:0061373 biolink:NamedThing mammillary axonal complex development The progression of the mammillary axonal complex over time, from its formation to the mature structure. The mammillary axonal complex is formed by the axons from the lateral, medial mammillary and the dorsal premammillary nuclei which share a branching pattern. Every neuron gives off one axonal stem that bifurcates into 2 branches. One of the branches is directed dorsally to the thalamus and another caudally to the midbrain. got7fsn_ti dph 2010-11-09T08:49:59Z biological_process owl:Class
GO:0033704 biolink:NamedThing 3beta-hydroxy-5alpha-steroid dehydrogenase activity Catalysis of the reaction: 3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + H(+) + NADPH. got7fsn_ti 3beta-hydroxy-5alpha-steroid:NADP+ 3-oxidoreductase activity MetaCyc:1.1.1.278-RXN|EC:1.1.1.278|KEGG_REACTION:R07138|RHEA:18137 molecular_function owl:Class
GO:0045062 biolink:NamedThing extrathymic T cell selection The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus. got7fsn_ti extrathymic T lymphocyte selection|extrathymic T-cell selection|extrathymic T-lymphocyte selection biological_process owl:Class
GO:0103093 biolink:NamedThing methylthioalkylmalate dehydrogenase activity Catalysis of the reaction: 3-(7'-methylthio)heptylmalate <=> H+ + 2-oxo-10-methylthiodecanoate + carbon dioxide. got7fsn_ti MetaCyc:RXNQT-4178 molecular_function owl:Class
GO:0030353 biolink:NamedThing fibroblast growth factor receptor antagonist activity Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist. got7fsn_ti FGFR antagonist activity|FGF receptor antagonist activity molecular_function owl:Class
GO:0036371 biolink:NamedThing protein localization to T-tubule A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. got7fsn_ti protein localisation to T-tubule|protein localization to transverse tubule|protein localization to T tubule bf 2012-10-08T17:10:29Z biological_process owl:Class
GO:0004348 biolink:NamedThing glucosylceramidase activity Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. got7fsn_ti acid beta-glucosidase activity|glucocerebrosidase activity|psychosine hydrolase activity|glucosylsphingosine beta-D-glucosidase activity|beta-glucocerebrosidase activity|glucosphingosine glucosylhydrolase activity|beta-D-glucocerebrosidase activity|glucosylsphingosine beta-glucosidase activity|GlcCer-beta-glucosidase activity|ceramide glucosidase activity|glucosylcerebrosidase activity|beta-glucosylceramidase activity|D-glucosyl-N-acylsphingosine glucohydrolase activity Reactome:R-HSA-1861789|MetaCyc:GLUCOSYLCERAMIDASE-RXN|Reactome:R-HSA-1861788|Reactome:R-HSA-1605591|RHEA:13269|EC:3.2.1.45 molecular_function owl:Class
GO:0072162 biolink:NamedThing metanephric mesenchymal cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the metanephros as it progresses from its formation to the mature state. got7fsn_ti mah 2010-02-26T01:35:00Z biological_process owl:Class
GO:0072161 biolink:NamedThing mesenchymal cell differentiation involved in kidney development The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the kidney as it progresses from its formation to the mature state. got7fsn_ti mah 2010-02-26T01:31:49Z biological_process owl:Class
GO:0072196 biolink:NamedThing proximal/distal pattern formation involved in pronephric nephron development The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of the pronephros. got7fsn_ti pronephros proximal/distal pattern formation mah 2010-03-01T02:11:07Z biological_process owl:Class
GO:0021719 biolink:NamedThing superior olivary nucleus morphogenesis The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. got7fsn_ti superior olive morphogenesis biological_process owl:Class
GO:0019653 biolink:NamedThing anaerobic purine nucleobase catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP. got7fsn_ti anaerobic purine base catabolism|anaerobic purine catabolic process|purine fermentation|purine base fermentation|anaerobic purine base catabolic process MetaCyc:PWY-5044|MetaCyc:PWY-5497|MetaCyc:P164-PWY biological_process owl:Class
GO:0006145 biolink:NamedThing purine nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. got7fsn_ti purine base catabolic process|purine base degradation|purine base breakdown|purine base catabolism biological_process owl:Class
GO:0018136 biolink:NamedThing peptidyl-thiazoline dehydrogenase activity Catalysis of the reduction of a peptide-linked thiazoline to thiazole. got7fsn_ti molecular_function owl:Class
GO:0102400 biolink:NamedThing dTDP-3-amino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N,N-dimethyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-alpha-D-glucose <=> 2 S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + 2 H+. got7fsn_ti MetaCyc:RXN-13667 molecular_function owl:Class
GO:0102727 biolink:NamedThing 3beta-hydroxysteroid dehydrogenase activity Catalysis of the reaction: campest-4-en-3beta-ol + NAD = campest-4-en-3-one + NADH + H+. got7fsn_ti MetaCyc:RXN-710 molecular_function owl:Class
GO:0030734 biolink:NamedThing polysaccharide O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units. got7fsn_ti S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity|polysaccharide methyltransferase activity|acylpolysacharide 6-methyltransferase activity MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN|EC:2.1.1.18 molecular_function owl:Class
GO:0050533 biolink:NamedThing 5-phytase activity Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate. got7fsn_ti myo-inositol-hexakisphosphate 5-phosphohydrolase activity RHEA:13001|EC:3.1.3.72|MetaCyc:3.1.3.72-RXN molecular_function owl:Class
GO:0048560 biolink:NamedThing establishment of anatomical structure orientation The process that determines the orientation of an anatomical structure with reference to an axis. got7fsn_ti biological_process owl:Class
GO:0140355 biolink:NamedThing cargo receptor ligand activity The activity of a gene product that interacts with a cargo receptor and initiates endocytosis. got7fsn_ti cargo pg 2019-05-27T09:56:50Z molecular_function owl:Class
GO:0050124 biolink:NamedThing N-acylneuraminate-9-phosphatase activity Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate. got7fsn_ti N-acylneuraminic (sialic) acid 9-phosphatase activity|N-acylneuraminate-9-phosphate phosphohydrolase activity|acylneuraminate 9-phosphatase activity|N-acylneuraminic acid 9-phosphate phosphatase activity EC:3.1.3.29|Reactome:R-HSA-4084989|MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN|RHEA:13057 molecular_function owl:Class
GO:0030014 biolink:NamedThing CCR4-NOT complex The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. got7fsn_ti cellular_component owl:Class
GO:0045523 biolink:NamedThing interleukin-27 receptor binding Binding to an interleukin-27 receptor. got7fsn_ti interleukin-27 receptor ligand|IL-27 molecular_function owl:Class
GO:0097294 biolink:NamedThing 'de novo' XMP biosynthetic process The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors. got7fsn_ti 'de novo' XMP synthesis|'de novo' XMP anabolism|'de novo' XMP biosynthesis|'de novo' XMP formation pr 2012-04-26T09:57:49Z biological_process owl:Class
GO:0097293 biolink:NamedThing XMP biosynthetic process The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate. got7fsn_ti XMP biosynthesis|XMP formation|XMP synthesis|XMP anabolism pr 2012-04-26T09:54:13Z biological_process owl:Class
GO:0004462 biolink:NamedThing lactoylglutathione lyase activity Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. got7fsn_ti (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity|(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)|aldoketomutase activity|ketone-aldehyde mutase activity|glyoxalase I activity|glyoxylase I|methylglyoxalase activity Reactome:R-HSA-5694071|MetaCyc:GLYOXI-RXN|RHEA:19069|KEGG_REACTION:R02530|EC:4.4.1.5 molecular_function owl:Class
GO:0102952 biolink:NamedThing UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP. got7fsn_ti RHEA:57708|MetaCyc:RXN-91 molecular_function owl:Class
GO:0007181 biolink:NamedThing transforming growth factor beta receptor complex assembly The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex. got7fsn_ti TGF-beta receptor complex assembly|TGFbeta receptor complex assembly|TGF-beta:type II receptor:type I receptor complex assembly biological_process owl:Class
GO:0047880 biolink:NamedThing erythrulose reductase activity Catalysis of the reaction: D-threitol + NADP(+) = D-erythrulose + H(+) + NADPH. got7fsn_ti D-erythrulose reductase activity|erythritol:NADP+ oxidoreductase activity EC:1.1.1.162|KEGG_REACTION:R08573|MetaCyc:ERYTHRULOSE-REDUCTASE-RXN|RHEA:18005 molecular_function owl:Class
GO:0018289 biolink:NamedThing molybdenum incorporation into metallo-sulfur cluster The incorporation of molybdenum into a metallo-sulfur cluster. got7fsn_ti molybdenum incorporation into metallo-sulphur cluster biological_process owl:Class
GO:0102621 biolink:NamedThing emindole-SB NADPH:oxygen oxidoreductase (14,15-epoxidizing) activity Catalysis of the reaction: emindole-SB + O2 + NADPH + H+ <=> 14,15-epoxyemindole-SB + NADP + H2O. got7fsn_ti MetaCyc:RXN-15496 molecular_function owl:Class
GO:0002125 biolink:NamedThing maternal aggressive behavior Aggressive behavior of a female to protect her offspring from a threat. got7fsn_ti maternal aggression Paternal aggression also exists. Serves to protect the offspring from intruders. biological_process owl:Class
GO:0010673 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. got7fsn_ti positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|activation of meiosis by positive regulation of transcription from RNA polymerase II promoter|up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter, meiotic dgf 2012-05-01T08:40:11Z GO:1900476 biological_process owl:Class
GO:0102803 biolink:NamedThing thebane O-demethylase activity Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> oripavine + formaldehyde + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-8149|EC:1.14.11.32 molecular_function owl:Class
GO:0010158 biolink:NamedThing abaxial cell fate specification The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0042711 biolink:NamedThing maternal behavior Female behaviors associated with the care and rearing of offspring. got7fsn_ti maternal behaviour biological_process owl:Class
GO:0102086 biolink:NamedThing N-vanillate-L-glutamate synthetase activity Catalysis of the reaction: vanillate + L-glutamate(1-) + ATP <=> H+ + N-vanillate-L-glutamate + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10885 molecular_function owl:Class
GO:0021505 biolink:NamedThing neural fold folding The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds. got7fsn_ti biological_process owl:Class
GO:0047154 biolink:NamedThing methylmalonyl-CoA carboxytransferase activity Catalysis of the reaction: pyruvate + D-methylmalonyl-CoA = oxaloacetic acid + propionyl-CoA. got7fsn_ti (S)-methylmalonyl-CoA:pyruvate carboxyltransferase activity|methylmalonyl coenzyme A carboxyltransferase activity|transcarboxylase activity|(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate|(S)-methylmalonyl-CoA:pyruvate carboxytransferase activity|methylmalonyl-CoA carboxyltransferase activity|(S)-2-methyl-3-oxopropanoyl-CoA:pyruvate carboxyltransferase activity|methylmalonyl-CoA transcarboxylase activity|oxalacetic transcarboxylase activity MetaCyc:2.1.3.1-RXN|UM-BBD_reactionID:r0923|RHEA:20764|EC:2.1.3.1 molecular_function owl:Class
GO:0048206 biolink:NamedThing vesicle targeting, cis-Golgi to rough endoplasmic reticulum The process in which vesicles are directed to specific destination membranes during transport from the cis-Golgi to the rough ER. got7fsn_ti cis-Golgi to rough endoplasmic reticulum targeting|cis-Golgi to rough ER targeting|vesicle targeting, cis-Golgi to rough endoplasmic reticulum|vesicle targeting, cis-Golgi to rough ER biological_process owl:Class
GO:0072086 biolink:NamedThing specification of loop of Henle identity The process in which the loop of Henle of the kidney nephron acquires its identity. got7fsn_ti specification of intermediate tubule identity mah 2010-02-01T02:49:35Z GO:0072083 biological_process owl:Class
GO:0031411 biolink:NamedThing gas vesicle An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations. got7fsn_ti gas vacuole Note that although this organelle is commonly referred to as a 'vesicle' or 'vacuole' in the literature, it is not surrounded by a membrane. cellular_component owl:Class
GO:0048520 biolink:NamedThing positive regulation of behavior Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. got7fsn_ti stimulation of behavior|activation of behavior|up-regulation of behavior|upregulation of behavior|up regulation of behavior biological_process owl:Class
GO:1990046 biolink:NamedThing stress-induced mitochondrial fusion Merging of two or more mitochondria within a cell to form a single compartment, as a result of a disturbance in cellular homeostasis. got7fsn_ti stress-induced mitochondrial hyperfusion|mitochondrial fusion in response to stress|SIMH pr 2013-02-15T16:01:55Z biological_process owl:Class
GO:0008053 biolink:NamedThing mitochondrial fusion Merging of two or more mitochondria within a cell to form a single compartment. got7fsn_ti biological_process owl:Class
GO:0034256 biolink:NamedThing chlorophyll(ide) b reductase activity Catalysis of the reaction: 71-hydroxychlorophyll(ide) a + NAD(P)+ = chlorophyll(ide) b + NAD(P)H + H+. got7fsn_ti Chl b reductase activity|chlorophyllide b reductase activity|chlorophyll b reductase activity MetaCyc:RXN-7678|EC:1.1.1.294 molecular_function owl:Class
GO:0071821 biolink:NamedThing FANCM-MHF complex A protein complex contains the proteins FANCM and MHF, or their orthologs, plays an essential role in DNA remodeling, protects replication forks, and is conserved in eukaryotes. got7fsn_ti mah 2010-09-07T12:08:38Z cellular_component owl:Class
GO:0106229 biolink:NamedThing histone glutaryltransferase activity Catalysis of the reaction: glutaryl-CoA + histone = CoA + H+ + N6-glutaryl-histone. got7fsn_ti hjd 2019-10-17T19:01:48Z molecular_function owl:Class
GO:0019643 biolink:NamedThing reductive tricarboxylic acid cycle A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate. got7fsn_ti reductive carboxylate cycle|reductive citric acid pathway|reductive TCA cycle|reductive Kreb's cycle|reductive carboxylic acid cycle GO:0019644 MetaCyc:REDCITCYC|MetaCyc:P23-PWY biological_process owl:Class
GO:0018030 biolink:NamedThing peptidyl-lysine N6-myristoyltransferase activity Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule. got7fsn_ti molecular_function owl:Class
GO:0018053 biolink:NamedThing C-terminal peptidyl-valine amidation The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0100 biological_process owl:Class
GO:0052042 biolink:NamedThing positive regulation by symbiont of host programmed cell death Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti activation by organism of host programmed cell death|upregulation by symbiont of host programmed cell death|induction of non-apoptotic programmed cell death by other organism|pathogenesis|activation by organism of programmed cell death in other organism during symbiotic interaction|induction by organism of programmed cell death in other organism involved in symbiotic interaction|induction by symbiont of host programmed cell death|induction by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction|enhancement of host programmed cell death|activation by organism of non-apoptotic programmed cell death in other organism|stimulation by symbiont of host programmed cell death|induction by organism of programmed cell death in other organism during symbiotic interaction|activation by symbiont of host programmed cell death|enhancement of host programmed cell death by organism|positive regulation by symbiont of host non-apoptotic programmed cell death GO:0012504|GO:0052400|GO:0052044|GO:0052397|GO:0052045|GO:0052153 biological_process owl:Class
GO:0102561 biolink:NamedThing D-ribose 2,5-bisphosphate 2-phosphohydrolase activity Catalysis of the reaction: H2O + D-ribofuranose 2,5-bisphosphate <=> hydrogenphosphate + D-ribofuranose 5-phosphate. got7fsn_ti RHEA:41616|EC:3.1.4.57|MetaCyc:RXN-14996 molecular_function owl:Class
GO:0043053 biolink:NamedThing dauer entry Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development. got7fsn_ti nematode entry into dormancy biological_process owl:Class
GO:0140074 biolink:NamedThing cardiac endothelial to mesenchymal transition A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes. got7fsn_ti EndoMT|EndMT pg 2017-07-21T09:39:49Z biological_process owl:Class
GO:0048762 biolink:NamedThing mesenchymal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. got7fsn_ti biological_process owl:Class
GO:0052858 biolink:NamedThing peptidyl-lysine acetyltransferase activity Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine. got7fsn_ti peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|acetyl-phosphate:peptidyl-L-lysine N6-acetyltransferase activity|peptidyl-lysine N6-acetyltransferase activity|acetyl-phosphate:peptidyl-L-lysine 6-N-acetyltransferase activity|peptidyl-lysine N(6)-acetyltransferase activity molecular_function owl:Class
GO:0031311 biolink:NamedThing intrinsic component of contractile vacuolar membrane The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to contractile vacuolar membrane cellular_component owl:Class
GO:0031094 biolink:NamedThing platelet dense tubular network A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin. got7fsn_ti cellular_component owl:Class
GO:2000610 biolink:NamedThing negative regulation of thyroid hormone generation Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation. got7fsn_ti yaf 2011-04-18T10:12:19Z biological_process owl:Class
GO:0050415 biolink:NamedThing formimidoylglutamase activity Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide. got7fsn_ti N-formiminoglutamate hydrolase activity|formiminoglutamase activity|N-formimidoyl-L-glutamate formimidoylhydrolase activity|formiminoglutamate hydrolase activity|N-formimino-L-glutamate formiminohydrolase activity MetaCyc:FORMIMINOGLUTAMASE-RXN|KEGG_REACTION:R02285|EC:3.5.3.8|RHEA:22492 molecular_function owl:Class
GO:0071732 biolink:NamedThing cellular response to nitric oxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. got7fsn_ti mah 2010-03-17T04:12:52Z biological_process owl:Class
GO:0045437 biolink:NamedThing uridine nucleosidase activity Catalysis of the reaction: H(2)O + uridine = ribofuranose + uracil. got7fsn_ti uridine ribohydrolase activity|uridine hydrolase activity MetaCyc:URIDINE-NUCLEOSIDASE-RXN|RHEA:15577|KEGG_REACTION:R01080|EC:3.2.2.3 molecular_function owl:Class
GO:0003055 biolink:NamedThing circadian regulation of heart rate by the suprachiasmatic nucleus The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours. got7fsn_ti SCN regulation of heart rate|circadian regulation of heart contraction rate by the suprachiasmatic nucleus|master pacemaker clock regulation of heart rate biological_process owl:Class
GO:0018598 biolink:NamedThing hydroxymethylsilanetriol oxidase activity Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol. got7fsn_ti UM-BBD_reactionID:r0641 molecular_function owl:Class
GO:0034642 biolink:NamedThing mitochondrion migration along actin filament The directed movement of a mitochondrion along a microfilament, mediated by motor proteins. got7fsn_ti mitochondrial migration, actin-mediated|mitochondrial migration along microfilament|mitochondrion migration along microfilament|mitochondrion transport along actin filament|mitochondrial migration along actin filament biological_process owl:Class
GO:0042121 biolink:NamedThing alginic acid biosynthetic process The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). got7fsn_ti alginic acid synthesis|alginate biosynthetic process|alginic acid formation|alginate biosynthesis|alginic acid anabolism|alginic acid biosynthesis biological_process owl:Class
GO:0010493 biolink:NamedThing Lewis a epitope biosynthetic process The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides. got7fsn_ti LE A biosynthetic process biological_process owl:Class
GO:0055043 biolink:NamedThing 5-oxovalerate dehydrogenase activity Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+. got7fsn_ti molecular_function owl:Class
GO:0019186 biolink:NamedThing acyl-CoA N-acyltransferase activity Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0140426 biolink:NamedThing PAMP-triggered immunity signalling pathway Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands to activate a plant innate immune response. PAMP-triggered immunity PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. got7fsn_ti pathogen-associated molecular pattern signalling|PTI signalling|MAMP-triggered immunity signalling https://github.com/geneontology/go-ontology/issues/18588 pg 2020-02-11T11:08:57Z biological_process owl:Class
GO:0004583 biolink:NamedThing dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide. got7fsn_ti Reactome:R-HSA-446194|MetaCyc:RXN-5472|Reactome:R-HSA-446189|Reactome:R-HSA-446202|Reactome:R-HSA-4724330|Reactome:R-HSA-4724291 molecular_function owl:Class
GO:0047743 biolink:NamedThing chlordecone reductase activity Catalysis of the reaction: chlordecone alcohol + NADP(+) = chlordecone + H(+) + NADPH. got7fsn_ti CDR activity|chlordecone-alcohol:NADP+ 2-oxidoreductase activity RHEA:14401|MetaCyc:CHLORDECONE-REDUCTASE-RXN|EC:1.1.1.225|KEGG_REACTION:R03716 molecular_function owl:Class
GO:0061757 biolink:NamedThing leukocyte adhesion to arterial endothelial cell The attachment of a leukocyte to an arterial endothelial cell via adhesion molecules. got7fsn_ti dph 2016-02-29T16:49:38Z biological_process owl:Class
GO:0035661 biolink:NamedThing MyD88-dependent toll-like receptor 2 signaling pathway Any series of molecular signals generated as a consequence of binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response. got7fsn_ti MyD88-dependent TLR2 signaling pathway|MyD88-dependent toll-like receptor 2 signalling pathway bf 2011-02-01T10:11:01Z biological_process owl:Class
GO:0034134 biolink:NamedThing toll-like receptor 2 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 2. got7fsn_ti TLR2 signaling pathway|toll-like receptor 2 signalling pathway biological_process owl:Class
GO:0006977 biolink:NamedThing DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle. got7fsn_ti positive regulation of cell cycle arrest by p53-mediated DNA damage response biological_process owl:Class
GO:0097715 biolink:NamedThing cellular response to viscosity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus. got7fsn_ti pr 2016-08-23T14:34:05Z biological_process owl:Class
GO:0097714 biolink:NamedThing response to viscosity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus. got7fsn_ti pr 2016-08-23T14:32:46Z biological_process owl:Class
GO:1990333 biolink:NamedThing mitotic checkpoint complex, CDC20-MAD2 subcomplex A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20. got7fsn_ti CDC20-MAD2 complex An example of this is cdc20 in Saccharomyces cerevisiae (P26309) in PMID:15879521 (inferred from direct assay). bhm 2014-03-17T14:11:35Z cellular_component owl:Class
GO:0002306 biolink:NamedThing CD4-positive gamma-delta intraepithelial T cell differentiation The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways. got7fsn_ti CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation|CD4-positive, gamma-delta intraepithelial T-cell differentiation|CD4-positive, gamma-delta intraepithelial T cell development|CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0061175 biolink:NamedThing type II terminal bouton Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. got7fsn_ti type II terminal button dph 2010-07-13T09:18:01Z cellular_component owl:Class
GO:0098540 biolink:NamedThing lumenal side of trans-Golgi network transport vesicle membrane The side (leaflet) of the trans-Golgi network transport vesicle membrane that faces the lumen. got7fsn_ti internal side of trans-Golgi network transport vesicle membrane dos 2013-10-24T11:55:02Z cellular_component owl:Class
GO:0098538 biolink:NamedThing lumenal side of transport vesicle membrane The side (leaflet) of the transport vesicle membrane that faces the lumen. got7fsn_ti internal side of transport vesicle membrane dos 2013-10-24T11:43:55Z cellular_component owl:Class
GO:0050527 biolink:NamedThing poly(3-hydroxyoctanoate) depolymerase activity Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5. got7fsn_ti poly(HA) depolymerase activity|poly{oxycarbonyl[(R)-2-pentylethylene]} hydrolase activity|PHO depolymerase activity|PHA depolymerase activity|poly((R)-3-hydroxyoctanoate) hydrolase activity|poly(HA(MCL)) depolymerase activity|poly(3HO) depolymerase activity|poly[(R)-3-hydroxyoctanoate] hydrolase activity|poly(HAMCL) depolymerase activity|poly[(R)-hydroxyalkanoic acid] depolymerase|poly((R)-hydroxyalkanoic acid) depolymerase activity MetaCyc:3.1.1.76-RXN|EC:3.1.1.76 molecular_function owl:Class
GO:0038028 biolink:NamedThing insulin receptor signaling pathway via phosphatidylinositol 3-kinase The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade. got7fsn_ti insulin receptor signaling via PI3K|insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade|insulin receptor signaling pathway via PI3K cascade|insulin receptor signalling pathway via phosphatidylinositol 3-kinase cascade bf 2011-09-08T10:35:14Z biological_process owl:Class
GO:0140585 biolink:NamedThing promoter-enhancer loop anchoring activity Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop. got7fsn_ti enhancer-promoter loop anchoring activity https://github.com/geneontology/go-ontology/issues/20204 Note that GO does not separately defines enhancers, since this concept is very close to that of cis-regulatory elements. However the literature refers to 'promoter-enhancer loops' to describe loops that bring together cis-regulatory elements. Note also that while SO defines 'promoter' as the core promoter, here it is used to mean a cis-regulatory element. pg 2021-02-04T14:50:04Z molecular_function owl:Class
GO:0047883 biolink:NamedThing ethanolamine oxidase activity Catalysis of the reaction: ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2. got7fsn_ti ethanolamine:oxygen oxidoreductase (deaminating) MetaCyc:ETHANOLAMINE-OXIDASE-RXN|RHEA:18581|EC:1.4.3.8 molecular_function owl:Class
GO:0047291 biolink:NamedThing lactosylceramide alpha-2,3-sialyltransferase activity Catalysis of the reaction: cytolipin-H + CMP-N-acetylneuraminate = alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + CMP. Alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide is also known as GM3. got7fsn_ti ganglioside GM3 synthase activity|GM3 synthase activity|CMP-N-acetylneuraminate:lactosylceramide alpha-2,3-N-acetylneuraminyltransferase activity|cytidine monophosphoacetylneuraminate-lactosylceramide sialyltransferase|CMP-acetylneuraminic acid:lactosylceramide sialyltransferase activity|SAT 1|GM3 synthetase activity|CMP-acetylneuraminate-lactosylceramide-sialyltransferase|ganglioside GM3 synthetase activity|CMP-sialic acid:lactosylceramide-sialyltransferase activity|cytidine monophosphoacetylneuraminate-lactosylceramide alpha2,3- sialyltransferase activity MetaCyc:2.4.99.9-RXN|EC:2.4.99.9|RHEA:18417 molecular_function owl:Class
GO:0036098 biolink:NamedThing male germ-line stem cell population maintenance The process by which an organism or tissue maintains a population of male germ-line stem cells. got7fsn_ti bf 2012-01-26T01:58:10Z biological_process owl:Class
GO:0030718 biolink:NamedThing germ-line stem cell population maintenance Any process by which an organism or tissue maintains a population of germ-line stem cells. got7fsn_ti biological_process owl:Class
GO:0016456 biolink:NamedThing X chromosome located dosage compensation complex, transcription activating An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster. got7fsn_ti dosage compensation complex cellular_component owl:Class
GO:0046557 biolink:NamedThing glucan endo-1,6-beta-glucosidase activity Catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans. got7fsn_ti 1,6-beta-D-glucan glucanohydrolase activity|beta-1->6-glucan hydrolase activity|endo-1,6-beta-glucanase activity|endo-1,6-beta-D-glucanase activity|beta-1,6-glucanase activity|beta-1,6-glucanase-pustulanase activity|beta-1,6-glucan 6-glucanohydrolase activity|endo-beta-1,6-glucanase activity|endo-(1->6)-beta-D-glucanase activity|beta-1,6-glucan hydrolase activity|endo-(1,6)-beta-D-glucanase activity EC:3.2.1.75|MetaCyc:3.2.1.75-RXN molecular_function owl:Class
GO:0047753 biolink:NamedThing choline-sulfatase activity Catalysis of the reaction: choline sulfate + H(2)O = choline + H(+) + sulfate. got7fsn_ti choline-sulphatase activity|choline-sulfate sulfohydrolase activity KEGG_REACTION:R01028|EC:3.1.6.6|MetaCyc:CHOLINE-SULFATASE-RXN|RHEA:20820 molecular_function owl:Class
GO:0051800 biolink:NamedThing phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Catalysis of the reaction: phosphatidylinositol-3,4-bisphosphate + H2O = phosphatidylinositol-4-phosphate + phosphate. got7fsn_ti PTEN activity Reactome:R-HSA-1676204|Reactome:R-HSA-1676149 molecular_function owl:Class
GO:0060156 biolink:NamedThing milk ejection reflex A reflex that occurs in response to suckling, beginning with a nerve impulse from a receptor in the mammary gland and ending with the ejection of milk from the gland. Signaling never reaches a level of consciousness. got7fsn_ti milk ejection biological_process owl:Class
GO:0071112 biolink:NamedThing alpha4-beta4 integrin-EMILIN-1 complex A protein complex that consists of an alpha4-beta4 integrin complex bound to EMILIN-1 (ElastinMicrofibril Interface Located ProteIN). got7fsn_ti ITGA4-ITGB4-EMILIN1 complex mah 2009-11-13T02:17:11Z cellular_component owl:Class
GO:0103077 biolink:NamedThing quercetin 3-glucoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: quercetin-3-glucoside + UDP-L-rhamnose <=> quercetin-3-O-glucoside-7-O-rhamnoside + UDP. got7fsn_ti MetaCyc:RXNQT-4161|RHEA:61188 molecular_function owl:Class
GO:0035983 biolink:NamedThing response to trichostatin A Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus. got7fsn_ti bf 2011-08-23T01:48:01Z biological_process owl:Class
GO:1990757 biolink:NamedThing ubiquitin ligase activator activity Binds to and increases the activity of a ubiquitin ligase. got7fsn_ti mitotic anaphase-promoting complex activator activity vw 2015-06-01T08:53:04Z GO:0061636 molecular_function owl:Class
GO:0075203 biolink:NamedThing positive regulation of penetration hypha formation Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation of symbiont penetration hypha formation for entry into host https://github.com/geneontology/go-ontology/issues/21121 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0000995 biolink:NamedThing RNA polymerase III general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III. got7fsn_ti core RNA polymerase III binding transcription factor activity|RNA polymerase III transcription factor activity, sequence-specific DNA binding|transcription factor activity, core RNA polymerase III binding|RNA polymerase III general initiation factor activity|sequence-specific DNA binding RNA polymerase III transcription factor activity https://github.com/geneontology/go-ontology/issues/15789|https://github.com/geneontology/go-ontology/issues/20253 krc 2010-08-23T03:41:48Z GO:0001034 molecular_function owl:Class
GO:0033443 biolink:NamedThing AAA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AAA codon. got7fsn_ti lysine tRNA Note that in the standard genetic code, AAA codes for lysine. molecular_function owl:Class
GO:0070150 biolink:NamedThing mitochondrial glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA in a mitochondrion, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:1990785 biolink:NamedThing response to water-immersion restraint stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile. got7fsn_ti response to immobilization stress combined with water immersion sl 2015-06-24T18:27:28Z biological_process owl:Class
GO:0021524 biolink:NamedThing visceral motor neuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0044803 biolink:NamedThing multi-organism membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism. got7fsn_ti jl 2013-09-10T15:11:41Z biological_process owl:Class
GO:0031052 biolink:NamedThing chromosome breakage Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage. got7fsn_ti establishment or maintenance of heterochromatin architecture Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences. biological_process owl:Class
GO:0061810 biolink:NamedThing NAD glycohydrolase activity Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose without proceeding through a cyclic ADP-ribose intermediate. got7fsn_ti dph 2016-11-11T13:18:54Z Reactome:R-HSA-9637699|EC:3.2.2.5 molecular_function owl:Class
GO:0033996 biolink:NamedThing levan fructotransferase (DFA-IV-forming) activity Catalysis of the reaction: beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)]n-D-fructofuranoside = beta-D-fructopyranosyl-(2->6)-[D-fructofuranosyl-(2->6)](n-1)-D-fructofuranoside + di-beta-D-fructofuranose 2,6':2',6-dianhydride. This reaction is the production of di-beta-D-fructofuranose 2,6':2',6-dianhydride (DFA IV) by successively eliminating the diminishing (2->6)-beta-D-fructan (levan) chain from the terminal D-fructosyl-D-fructosyl disaccharide. got7fsn_ti 2,6-beta-D-fructan lyase (di-beta-D-fructofuranose-2,6':2',6-dianhydride-forming) activity|levan fructotransferase activity|2,6-beta-D-fructan D-fructosyl-D-fructosyltransferase (forming di-beta-D-fructofuranose 2,6':2',6-dianhydride) activity MetaCyc:4.2.2.16-RXN|EC:4.2.2.16 molecular_function owl:Class
GO:0099559 biolink:NamedThing maintenance of alignment of postsynaptic density and presynaptic active zone The process by which alignment between postsynaptic density and presynaptic active zone is maintained. got7fsn_ti biological_process owl:Class
GO:1901098 biolink:NamedThing positive regulation of autophagosome maturation Any process that activates or increases the frequency, rate or extent of autophagosome maturation. got7fsn_ti up-regulation of autolysosome formation|up-regulation of autophagosome maturation|upregulation of autophagosome maturation|up-regulation of autophagic vacuole maturation|up regulation of fusion of autophagosome with lysosome|activation of autophagic vacuole maturation|positive regulation of amphisome-lysosome fusion|upregulation of autolysosome formation|upregulation of fusion of autophagosome with lysosome|upregulation of autophagic vacuole fusion|up regulation of autophagosome maturation|activation of autophagic vacuole fusion|upregulation of autophagic vacuole maturation|activation of autophagosome maturation|activation of autolysosome formation|upregulation of amphisome-lysosome fusion|positive regulation of autophagic vacuole fusion|positive regulation of fusion of autophagosome with lysosome|activation of fusion of autophagosome with lysosome|positive regulation of autophagosome maturation|up-regulation of fusion of autophagosome with lysosome|up regulation of amphisome-lysosome fusion|up regulation of autophagic vacuole fusion|positive regulation of autolysosome formation|up regulation of autolysosome formation|activation of amphisome-lysosome fusion|positive regulation of autophagosome fusion|up-regulation of amphisome-lysosome fusion|up-regulation of autophagic vacuole fusion|up regulation of autophagic vacuole maturation lb 2012-07-10T07:22:34Z GO:1902454 biological_process owl:Class
GO:0033280 biolink:NamedThing response to vitamin D Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. got7fsn_ti response to cholecalciferol|response to calciferol|response to ergocalciferol biological_process owl:Class
GO:0060444 biolink:NamedThing branching involved in mammary gland duct morphogenesis The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. got7fsn_ti mammary gland branching morphogenesis biological_process owl:Class
GO:0051007 biolink:NamedThing squalene-hopene cyclase activity Catalysis of the reaction: squalene = hop-22(29)-ene. got7fsn_ti squalene mutase (cyclizing)|squalene:hopene cyclase activity EC:5.4.99.17|MetaCyc:5.4.99.17-RXN|RHEA:17637 molecular_function owl:Class
GO:0018787 biolink:NamedThing 4-chlorobenzoyl-CoA dehalogenase activity Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride. got7fsn_ti 4-chlorobenzoyl CoA chlorohydrolase activity UM-BBD_enzymeID:e0113|MetaCyc:3.8.1.7-RXN|RHEA:14853|EC:3.8.1.7 molecular_function owl:Class
GO:0046332 biolink:NamedThing SMAD binding Binding to a SMAD signaling protein. got7fsn_ti molecular_function owl:Class
GO:0070748 biolink:NamedThing interleukin-35 receptor binding Binding to an interleukin-35 receptor. got7fsn_ti interleukin-35 receptor ligand|IL-35 mah 2009-06-23T01:21:54Z molecular_function owl:Class
GO:0102425 biolink:NamedThing myricetin 3-O-glucosyltransferase activity Catalysis of the reaction: myricetin + UDP-alpha-D-glucose <=> myricetin 3-O-beta-D-glucopyranoside + UDP. got7fsn_ti MetaCyc:RXN-13822|EC:2.4.1.91 molecular_function owl:Class
GO:0102430 biolink:NamedThing alpha-linolenate delta5 desaturase activity Catalysis of the reaction: alpha-linolenate + O2 + a reduced electron acceptor = coniferonate + 2 H2O + an oxidized electron acceptor. got7fsn_ti RHEA:38039|MetaCyc:RXN-13857 molecular_function owl:Class
GO:0009368 biolink:NamedThing endopeptidase Clp complex A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form. got7fsn_ti cellular_component owl:Class
GO:0070940 biolink:NamedThing dephosphorylation of RNA polymerase II C-terminal domain The process of removing a phosphate group from an amino acid residue in the C-terminal domain of RNA polymerase II. Some dephosphorylation occurs during transcription while some may occur after the enzyme is released from the template in order to prepare it for the beginning of the transcription cycle again. RNA polymerase II with little or no phosphorylation is referred to as the hypophosphorylated or II(A) form. got7fsn_ti generation of II(A) form of RNA polymerase II|CTD domain dephosphorylation of RNA polymerase II|generation of hypophosphorylated CTD of RNA polymerase II mah 2009-09-29T04:34:14Z biological_process owl:Class
GO:1902533 biolink:NamedThing positive regulation of intracellular signal transduction Any process that activates or increases the frequency, rate or extent of intracellular signal transduction. got7fsn_ti up-regulation of signal transduction via intracellular signaling cascade|upregulation of signal transduction via intracellular signaling cascade|activation of intracellular signaling pathway|upregulation of intracellular signaling pathway|activation of intracellular signaling cascade|positive regulation of intracellular signaling chain|activation of intracellular signal transduction pathway|up-regulation of intracellular signal transduction pathway|activation of intracellular signal transduction|up regulation of intracellular signaling pathway|up regulation of signal transmission via intracellular cascade|positive regulation of intracellular signaling cascade|up-regulation of signal transmission via intracellular cascade|upregulation of intracellular signaling chain|activation of intracellular signaling chain|up-regulation of intracellular signaling pathway|up regulation of intracellular signal transduction pathway|positive regulation of signal transduction via intracellular signaling cascade|upregulation of intracellular signaling cascade|up-regulation of intracellular signaling cascade|positive regulation of signal transmission via intracellular cascade|up regulation of intracellular signal transduction|up regulation of intracellular signaling cascade|up regulation of intracellular signaling chain|upregulation of signal transmission via intracellular cascade|up-regulation of intracellular signal transduction|upregulation of intracellular signal transduction pathway|positive regulation of intracellular signaling pathway|upregulation of intracellular signal transduction|activation of signal transmission via intracellular cascade|up regulation of signal transduction via intracellular signaling cascade|up-regulation of intracellular signaling chain|positive regulation of intracellular protein kinase cascade|activation of signal transduction via intracellular signaling cascade|positive regulation of intracellular signal transduction pathway bf 2013-12-02T11:33:10Z GO:0010740 biological_process owl:Class
GO:0010293 biolink:NamedThing abscisic aldehyde oxidase activity Catalysis of the reaction: (+)-abscisic aldehyde + H(2)O + O(2) = abscisate + H(2)O(2) + H(+). got7fsn_ti AAO3|abscisic-aldehyde oxidase activity|AOdelta|abscisic-aldehyde:oxygen oxidoreductase activity GO:0033725 EC:1.2.3.14|KEGG_REACTION:R06957|MetaCyc:1.2.3.14-RXN|RHEA:20529 molecular_function owl:Class
GO:0102864 biolink:NamedThing 1-18:3-2-18:2-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:3-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8331 molecular_function owl:Class
GO:0004473 biolink:NamedThing malate dehydrogenase (decarboxylating) (NADP+) activity Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. got7fsn_ti NADP-specific malic enzyme|NADP-malic enzyme activity|L-malate:NADP oxidoreductase activity|NADP-linked decarboxylating malic enzyme|malate dehydrogenase (decarboxylating, NADP)|NADP-specific malate dehydrogenase activity|'malic' enzyme|(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)|malate dehydrogenase (NADP, decarboxylating) For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'. Reactome:R-HSA-9012036|KEGG_REACTION:R00216|Reactome:R-HSA-9012349|MetaCyc:MALIC-NADP-RXN|EC:1.1.1.40|RHEA:18253 molecular_function owl:Class
GO:0102102 biolink:NamedThing homocarnosine synthase activity Catalysis of the reaction: gamma-aminobutyric acid + L-histidine + ATP = H+ + homocarnosine + ADP + hydrogenphosphate. got7fsn_ti RHEA:59568|EC:6.3.2.11|MetaCyc:RXN-11222 molecular_function owl:Class
GO:0050686 biolink:NamedThing negative regulation of mRNA processing Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing. got7fsn_ti down-regulation of mRNA processing|downregulation of mRNA processing|inhibition of mRNA processing|down regulation of mRNA processing biological_process owl:Class
GO:1990338 biolink:NamedThing laminin-14 complex A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains. got7fsn_ti laminin-423 bhm 2014-03-20T23:37:11Z cellular_component owl:Class
GO:0002937 biolink:NamedThing tRNA 4-thiouridine biosynthesis The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs. got7fsn_ti In E. coli, two genes are involved, nuvA (aka Thi) and NuvC (aka iscS) . NuvA converts the trNA into an unidentified intermediate in an ATP dependent manner. NucC catalyzes the second step, transferring the sulfur from cysteine to an unidentified intermediate. NuvC also participates in thiamine synthesis. hjd 2012-10-19T15:26:28Z biological_process owl:Class
GO:0140057 biolink:NamedThing vacuole-mitochondria membrane tethering The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. got7fsn_ti pg 2017-06-27T10:31:12Z biological_process owl:Class
GO:1990024 biolink:NamedThing C bouton Synaptic bouton found in spinal cord on the soma and proximal dendrites of motor neurons. got7fsn_ti pr 2013-02-06T10:27:41Z NIF_Subcellular:nlx_subcell_100208 cellular_component owl:Class
GO:0047313 biolink:NamedThing aromatic-amino-acid-glyoxylate transaminase activity Catalysis of the reaction: glyoxylate + an aromatic amino acid = L-glycine + an aromatic oxo acid. got7fsn_ti aromatic-amino-acid:glyoxylate aminotransferase activity|aromatic-amino-acid-glyoxylate aminotransferase activity|aromatic-amino-acid--glyoxylate aminotransferase activity EC:2.6.1.60|MetaCyc:2.6.1.60-RXN|RHEA:10900 molecular_function owl:Class
GO:1901607 biolink:NamedThing alpha-amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of an alpha-amino acid. got7fsn_ti alpha-amino acid synthesis|alpha-amino acid formation|alpha-amino acid anabolism|alpha-amino acid biosynthesis tb 2012-11-08T17:39:58Z biological_process owl:Class
GO:0071455 biolink:NamedThing cellular response to hyperoxia Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. got7fsn_ti cellular response to hyperoxic stress|cellular response to increased oxygen tension mah 2009-12-16T04:44:41Z biological_process owl:Class
GO:0009882 biolink:NamedThing blue light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation. got7fsn_ti molecular_function owl:Class
GO:0036158 biolink:NamedThing outer dynein arm assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. got7fsn_ti ODA assembly bf 2012-03-21T02:25:01Z biological_process owl:Class
GO:0015042 biolink:NamedThing trypanothione-disulfide reductase activity Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide. got7fsn_ti trypanothione-disulphide reductase activity|trypanothione:NADP+ oxidoreductase activity|NADPH:trypanothione oxidoreductase activity|N1,N8-bis(glutathionyl)spermidine reductase activity|trypanothione reductase activity|N(1),N(8)-bis(glutathionyl)spermidine reductase activity Note that this function was formerly EC:1.6.4.8. MetaCyc:1.8.1.12-RXN|EC:1.8.1.12|RHEA:16757 molecular_function owl:Class
GO:0005157 biolink:NamedThing macrophage colony-stimulating factor receptor binding Binding to a macrophage colony-stimulating factor receptor. got7fsn_ti macrophage colony-stimulating factor receptor ligand|M-CSF receptor binding|macrophage colony stimulating factor receptor binding molecular_function owl:Class
GO:0061140 biolink:NamedThing lung secretory cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part. got7fsn_ti dph 2010-05-25T09:28:53Z biological_process owl:Class
GO:0097243 biolink:NamedThing flavonoid binding Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge. got7fsn_ti pr 2012-02-17T03:49:16Z molecular_function owl:Class
GO:0004732 biolink:NamedThing pyridoxal oxidase activity Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide. got7fsn_ti pyridoxal:oxygen 4-oxidoreductase activity EC:1.2.3.8|RHEA:23724|MetaCyc:PYRIDOXAL-OXIDASE-RXN molecular_function owl:Class
GO:0046213 biolink:NamedThing methyl ethyl ketone catabolic process The chemical reactions and pathways resulting in the breakdown of methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. got7fsn_ti methyl ethyl ketone catabolism|methyl ethyl ketone breakdown|methyl ethyl ketone degradation biological_process owl:Class
GO:0071460 biolink:NamedThing cellular response to cell-matrix adhesion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell-matrix adhesion. got7fsn_ti mah 2009-12-17T02:25:45Z biological_process owl:Class
GO:0019561 biolink:NamedThing anaerobic phenylalanine oxidation The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde. got7fsn_ti MetaCyc:ANAPHENOXI-PWY biological_process owl:Class
GO:0006559 biolink:NamedThing L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. got7fsn_ti phenylalanine catabolism|L-phenylalanine breakdown|phenylalanine catabolic process|L-phenylalanine degradation|L-phenylalanine catabolism biological_process owl:Class
GO:0047090 biolink:NamedThing benzoyl-CoA 3-monooxygenase activity Catalysis of the reaction: benzoyl-CoA + H(+) + NADPH + O(2) = 3-hydroxybenzoyl-CoA + H(2)O + NADP(+). got7fsn_ti benzoyl-CoA,NADPH:oxygen oxidoreductase (3-hydroxylating)|benzoyl-CoA 3-hydroxylase activity KEGG_REACTION:R02449|RHEA:23216|EC:1.14.13.58|MetaCyc:1.14.13.58-RXN molecular_function owl:Class
GO:0032943 biolink:NamedThing mononuclear cell proliferation The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. got7fsn_ti PBMC proliferation|peripheral blood mononuclear cell proliferation biological_process owl:Class
GO:0032389 biolink:NamedThing MutLalpha complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2. got7fsn_ti MLH1/PMS2 complex|MMR complex|MutL-alpha complex cellular_component owl:Class
GO:0048905 biolink:NamedThing anterior lateral line neuromast mantle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded. got7fsn_ti biological_process owl:Class
GO:0102930 biolink:NamedThing 4-hydroxybenzoate geranyltransferase activity Catalysis of the reaction: geranyl diphosphate + 4-hydroxybenzoic acid = 3-geranyl-4-hydroxybenzoate + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8920|EC:2.5.1.93|RHEA:27854 molecular_function owl:Class
GO:0032089 biolink:NamedThing NACHT domain binding Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs. got7fsn_ti molecular_function owl:Class
GO:0035918 biolink:NamedThing negative regulation of voltage-gated calcium channel activity in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti down-regulation of voltage-gated calcium channel activity in other organism|downregulation of voltage-gated calcium channel activity in other organism|negative regulation of voltage-sensitive calcium channel activity in other organism|inhibition of voltage-gated calcium channel activity in other organism|negative regulation of voltage gated calcium channel activity in other organism|negative regulation of voltage-dependent calcium channel activity in other organism bf 2011-07-01T11:54:43Z biological_process owl:Class
GO:0030423 biolink:NamedThing targeting of mRNA for destruction involved in RNA interference The process in which small interfering RNAs target cognate mRNA molecules for degradation. got7fsn_ti RNA interference, targeting of mRNA for destruction biological_process owl:Class
GO:0038149 biolink:NamedThing C-C motif chemokine 2 receptor activity Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti CCL2 receptor activity bf 2012-05-11T11:37:16Z molecular_function owl:Class
GO:0060963 biolink:NamedThing positive regulation of ribosomal protein gene transcription by RNA polymerase II Any process that increases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. got7fsn_ti positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter dph 2009-10-05T03:04:05Z biological_process owl:Class
GO:0007481 biolink:NamedThing haltere disc morphogenesis The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum. got7fsn_ti haltere disc metamorphosis biological_process owl:Class
GO:1990511 biolink:NamedThing piRNA biosynthetic process The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. got7fsn_ti Piwi-associated RNA biosynthetic process kmv 2014-10-07T13:47:32Z biological_process owl:Class
GO:0007384 biolink:NamedThing specification of segmental identity, thorax The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0035292 biolink:NamedThing specification of segmental identity, trunk The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0031756 biolink:NamedThing Edg-3 sphingosine 1-phosphate receptor binding Binding to an Edg-3 sphingosine 1-phosphate receptor. got7fsn_ti Edg-3 sphingosine 1-phosphate receptor ligand molecular_function owl:Class
GO:0106377 biolink:NamedThing 2-hydroxy-ATP hydrolase activity Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + diphosphate. got7fsn_ti hjd 2021-04-23T00:12:31Z molecular_function owl:Class
GO:0004800 biolink:NamedThing thyroxine 5'-deiodinase activity Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. got7fsn_ti iodothyronine 5'-deiodinase activity|thyroxine 5' deiodinase activity|diiodothyronine 5'-deiodinase activity|outer ring-deiodinating pathway|type I iodothyronine deiodinase activity|thyroxine deiodinase activity|acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)|iodothyronine outer ring monodeiodinase activity|L-thyroxine iodohydrolase (reducing) activity|type II iodothyronine deiodinase activity Note that this was EC:3.8.1.4. MetaCyc:THYROXINE-DEIODINASE-RXN|Reactome:R-HSA-350869|RHEA:19745|Reactome:R-HSA-209772|EC:1.21.99.4 molecular_function owl:Class
GO:0035384 biolink:NamedThing thioester biosynthetic process The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol. got7fsn_ti thioester formation|thioester anabolism|thioester synthesis|thioester biosynthesis bf 2010-03-18T01:52:11Z biological_process owl:Class
GO:0030148 biolink:NamedThing sphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). got7fsn_ti sphingolipid synthesis|sphingolipid formation|sphingolipid biosynthesis|sphingolipid anabolism MetaCyc:PWY-5129 biological_process owl:Class
GO:0035281 biolink:NamedThing pre-miRNA export from nucleus Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product. got7fsn_ti pre-microRNA transport from nucleus to cytoplasm|pre-microRNA export from nucleus|pre-microRNA export from cell nucleus|pre-microRNA-nucleus export|pre-microRNA export out of nucleus biological_process owl:Class
GO:0006405 biolink:NamedThing RNA export from nucleus The directed movement of RNA from the nucleus to the cytoplasm. got7fsn_ti RNA transport from nucleus to cytoplasm|RNA export out of nucleus|RNA export from cell nucleus|RNA-nucleus export biological_process owl:Class
GO:0018866 biolink:NamedThing adamantanone metabolic process The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists. got7fsn_ti adamantanone metabolism UM-BBD_pathwayID:ada biological_process owl:Class
GO:0102857 biolink:NamedThing 1-18:1-2-18:3-phosphatidylcholinedesaturase activity Catalysis of the reaction: 1-18:1-2-18:3-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8324|EC:1.14.19.22 molecular_function owl:Class
GO:0007554 biolink:NamedThing regulation of ecdysteroid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. got7fsn_ti regulation of ecdysteroid anabolism|regulation of ecdysteroid biosynthesis|regulation of ecdysteroid formation|regulation of ecdysteroid synthesis biological_process owl:Class
GO:0047097 biolink:NamedThing phylloquinone monooxygenase (2,3-epoxidizing) activity Catalysis of the reaction: AH(2) + O(2) + phylloquinone = 2,3-epoxyphylloquinone + A + H(2)O. got7fsn_ti vitamin K 2,3-epoxidase activity|phylloquinone,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)|vitamin K epoxidase activity|phylloquinone epoxidase activity|vitamin K1 epoxidase activity EC:1.14.99.20|MetaCyc:1.14.99.20-RXN|KEGG_REACTION:R03510|RHEA:16745 molecular_function owl:Class
GO:0070679 biolink:NamedThing inositol 1,4,5 trisphosphate binding Binding to inositol 1,4,5 trisphosphate. got7fsn_ti InsP3 binding|IP3 binding mah 2009-05-29T04:07:00Z molecular_function owl:Class
GO:0033661 biolink:NamedThing effector-mediated defense to host-produced reactive oxygen species A process mediated by a molecule secreted by a symbiont that results in the suppression of reactive oxygen species produced by the host as part of its innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti down regulation by organism of defense-related host metabolic burst|negative regulation by organism of defense-related host ROS production|suppression by symbiont of defense-related host reactive oxygen species production|down-regulation by organism of defense-related host oxidative burst|negative regulation by organism of defense-related host ROI production|negative regulation by organism of defense-related host reactive oxidative species production|inhibition by organism of defense-related host active oxygen species production|negative regulation by organism of defense-related host reactive oxygen intermediate production|negative regulation by organism of defense-related host respiratory burst|negative regulation by symbiont of defense-related host reactive oxygen species production|downregulation by organism of defense-related host AOS production https://github.com/geneontology/go-ontology/issues/18697 biological_process owl:Class
GO:0120149 biolink:NamedThing host cell peroxisome A small host cell organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. got7fsn_ti host peroxisome krc 2018-04-13T15:36:40Z cellular_component owl:Class
GO:0017051 biolink:NamedThing retinol dehydratase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol. got7fsn_ti molecular_function owl:Class
GO:0010938 biolink:NamedThing cytoplasmic microtubule depolymerization The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule. got7fsn_ti biological_process owl:Class
GO:0031122 biolink:NamedThing cytoplasmic microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. got7fsn_ti cytoplasmic microtubule organization and biogenesis|cytoplasmic microtubule organisation biological_process owl:Class
GO:0072438 biolink:NamedThing response to DNA replication checkpoint signaling A process that occurs in response to signals generated as a result of DNA replication checkpoint signaling. got7fsn_ti response to signal involved in DNA replication checkpoint|DNA replication checkpoint effector process mah 2010-12-08T04:53:12Z biological_process owl:Class
GO:0018411 biolink:NamedThing protein glucuronidation The modification of a protein by amino acid glucuronidation. got7fsn_ti protein amino acid glucuronidation biological_process owl:Class
GO:0045721 biolink:NamedThing negative regulation of gluconeogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis. got7fsn_ti down-regulation of gluconeogenesis|down regulation of gluconeogenesis|downregulation of gluconeogenesis|inhibition of gluconeogenesis biological_process owl:Class
GO:0004854 biolink:NamedThing xanthine dehydrogenase activity Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+. got7fsn_ti xanthine-NAD oxidoreductase activity|xanthine:NAD+ oxidoreductase activity|xanthine/NAD(+) oxidoreductase activity|NAD-xanthine dehydrogenase activity|xanthine/NAD+ oxidoreductase activity|xanthine oxidoreductase activity RHEA:16669|MetaCyc:RXN0-901|EC:1.17.1.4 molecular_function owl:Class
GO:0042062 biolink:NamedThing long-term strengthening of neuromuscular junction Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse. got7fsn_ti biological_process owl:Class
GO:0050806 biolink:NamedThing positive regulation of synaptic transmission Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. got7fsn_ti upregulation of synaptic transmission|up-regulation of synaptic transmission|stimulation of synaptic transmission|up regulation of synaptic transmission|activation of synaptic transmission biological_process owl:Class
GO:0070359 biolink:NamedThing actin polymerization-dependent cell motility involved in migration of symbiont in host A process involved in the controlled movement of a bacterial cell within a host cell, powered by the continuous polymerization of host actin at one pole of the cell. got7fsn_ti actin polymerization-dependent cell motility involved in migration of symbiont within host biological_process owl:Class
GO:0035062 biolink:NamedThing omega speckle A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs). got7fsn_ti cellular_component owl:Class
GO:0042723 biolink:NamedThing thiamine-containing compound metabolic process The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it. got7fsn_ti thiamine and derivative metabolism|thiamine-containing compound metabolism|thiamine and derivative metabolic process|thiamin-containing compound metabolic process|thiamin and derivative metabolic process|thiamin and derivative metabolism|vitamin B1 and derivative metabolism|vitamin B1 and derivative metabolic process biological_process owl:Class
GO:0042356 biolink:NamedThing GDP-4-dehydro-D-rhamnose reductase activity Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed. got7fsn_ti GDP-4-keto-D-rhamnose reductase activity|GDP-4-keto-6-deoxy-D-mannose reductase activity|GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase activity|guanosine diphosphate-4-keto-D-rhamnose reductase activity EC:1.1.1.187|MetaCyc:GDP-4-DEHYDRO-D-RHAMNOSE-REDUCTASE-RXN molecular_function owl:Class
GO:0018661 biolink:NamedThing orcinol 2-monooxygenase activity Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+). got7fsn_ti orcinol hydroxylase activity|orcinol,NADH:oxygen oxidoreductase (2-hydroxylating) KEGG_REACTION:R02830|MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN|EC:1.14.13.6|RHEA:19601|UM-BBD_reactionID:r0092 molecular_function owl:Class
GO:0052836 biolink:NamedThing inositol 5-diphosphate pentakisphosphate 5-kinase activity Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate. got7fsn_ti ai 2011-11-29T01:14:22Z Reactome:R-HSA-1855224|Reactome:R-HSA-1855158 molecular_function owl:Class
GO:1990055 biolink:NamedThing phenylacetaldehyde synthase activity Catalyzes the reaction: L-phenylalanine + O2 + H2O -> phenylacetaldehyde + ammonia + hydrogen peroxide + CO2. got7fsn_ti aromatic aldehyde synthase tb 2013-02-25T20:22:35Z EC:4.1.1.109|RHEA:55532 molecular_function owl:Class
GO:0022417 biolink:NamedThing protein maturation by protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein. got7fsn_ti biological_process owl:Class
GO:0050314 biolink:NamedThing sym-norspermidine synthase activity Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H(+). got7fsn_ti S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase activity RHEA:23244|MetaCyc:SYM-NORSPERMIDINE-SYNTHASE-RXN|KEGG_REACTION:R03271|EC:2.5.1.23 molecular_function owl:Class
GO:0050333 biolink:NamedThing thiamin-triphosphatase activity Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate. got7fsn_ti ThTPase activity|thiamine-triphosphatase activity|thiamine-triphosphate phosphohydrolase activity GO:0048253 EC:3.6.1.28|KEGG_REACTION:R00618|Reactome:R-HSA-965067|MetaCyc:THIAMIN-TRIPHOSPHATASE-RXN|RHEA:11744 molecular_function owl:Class
GO:0044149 biolink:NamedThing positive regulation of formation of structure involved in a symbiotic process Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. got7fsn_ti positive regulation of development of symbiont involved in interaction with host|positive regulation of development of symbiont during interaction with host https://github.com/geneontology/go-ontology/issues/20305 This term partially replaces the obsolete term 'positive regulation of growth or development of symbiont during interaction with host ; GO:0075339'. See also 'positive regulation of growth of symbiont during interaction with host ; GO:0044148'. jl 2009-08-06T02:20:55Z biological_process owl:Class
GO:0097488 biolink:NamedThing multivesicular body, internal vesicle membrane The lipid bilayer surrounding a multivesicular body internal vesicle. got7fsn_ti pr 2013-07-08T20:36:33Z cellular_component owl:Class
GO:0048572 biolink:NamedThing short-day photoperiodism Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a day length that falls short of a particular duration known as the 'critical day length'. The critical day length varies between species. Although the term short-day is used, most species actually respond to the duration of the night, so that the response will occur when a period of darkness exceeds the number of hours defined by 24 hours minus the critical day length. got7fsn_ti long-night photoperiodism|response to long-night|response to short-day|response to short-day photoperiod biological_process owl:Class
GO:0032988 biolink:NamedThing ribonucleoprotein complex disassembly The disaggregation of a protein-RNA complex into its constituent components. got7fsn_ti RNA-protein complex disassembly|protein-RNA complex disassembly|RNP complex disassembly biological_process owl:Class
GO:0071826 biolink:NamedThing ribonucleoprotein complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. got7fsn_ti ribonucleoprotein complex subunit organisation|RNA-protein complex subunit organization|protein-RNA complex subunit organization mah 2010-09-08T10:10:35Z biological_process owl:Class
GO:0098996 biolink:NamedThing disruption of host cell glycocalyx during viral entry The disruption of host cell glycocalyx by viral proteins during virus entry. got7fsn_ti degradation of host capsule during virus entry|catabolism of host glycocalyx during viral entry|degradation of host glycocalyx during viral entry|disassembly of glycocalyx during viral entry VZ:3938 biological_process owl:Class
GO:0033459 biolink:NamedThing GAA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GAA codon. got7fsn_ti glutamic acid tRNA Note that in the standard genetic code, GAA codes for glutamic acid. molecular_function owl:Class
GO:0072143 biolink:NamedThing mesangial cell development The process whose specific outcome is the progression of a mesangial cell in the kidney over time, from its formation to the mature structure. got7fsn_ti mah 2010-02-24T01:44:28Z biological_process owl:Class
GO:0102791 biolink:NamedThing sulfuretin synthase activity Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 + 2 H+ = sulfuretin 6-glucoside + 2 H2O. got7fsn_ti MetaCyc:RXN-8008|EC:1.21.3.6 molecular_function owl:Class
GO:0050275 biolink:NamedThing scopoletin glucosyltransferase activity Catalysis of the reaction: scopoletin + UDP-D-glucose = H(+) + scopolin + UDP. got7fsn_ti UDPglucose:scopoletin O-beta-D-glucosyltransferase activity|SGTase activity|UDP-glucose:scopoletin O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-scopoletin glucosyltransferase activity|UDPglucose:scopoletin glucosyltransferase activity RHEA:20453|MetaCyc:SCOPOLETIN-GLUCOSYLTRANSFERASE-RXN|EC:2.4.1.128|KEGG_REACTION:R03594 molecular_function owl:Class
GO:0072494 biolink:NamedThing host multivesicular body A late endosome in which regions of the limiting host cell endosomal membrane invaginate to form internal vesicles; host membrane proteins that enter the internal vesicles are sequestered from the host cytoplasm. got7fsn_ti host cell multivesicular body mah 2010-12-15T11:48:39Z cellular_component owl:Class
GO:0010210 biolink:NamedThing IAA-Phe conjugate hydrolase activity Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine. got7fsn_ti molecular_function owl:Class
GO:0046421 biolink:NamedThing methylisocitrate lyase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate. got7fsn_ti (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase activity|2-methylisocitrate lyase activity|MICL|(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming) RHEA:16809|EC:4.1.3.30|MetaCyc:METHYLISOCITRATE-LYASE-RXN|KEGG_REACTION:R00409 molecular_function owl:Class
GO:0021532 biolink:NamedThing neural tube patterning The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube. got7fsn_ti biological_process owl:Class
GO:0070048 biolink:NamedThing endobrevin-SNAP-25-syntaxin-1a complex A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 1a (or orthologs thereof). got7fsn_ti SNARE complex (Stx1a, Snap25, Vamp8)|Stx1a-Snap25-Vamp8 complex cellular_component owl:Class
GO:0039530 biolink:NamedThing MDA-5 signaling pathway Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. got7fsn_ti MDA5 signaling pathway|IFIH1 signaling pathway|MDA-5 signalling pathway|melanoma differentiation-associated gene 5 signaling pathway bf 2011-12-20T03:14:52Z biological_process owl:Class
GO:0044398 biolink:NamedThing envenomation resulting in induction of edema in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation. got7fsn_ti envenomation resulting in induction of oedema in other organism jl 2011-12-21T03:57:27Z biological_process owl:Class
GO:0031340 biolink:NamedThing positive regulation of vesicle fusion Any process that activates or increases the frequency, rate or extent of vesicle fusion. got7fsn_ti up-regulation of vesicle fusion|up regulation of vesicle fusion|stimulation of vesicle fusion|upregulation of vesicle fusion|activation of vesicle fusion biological_process owl:Class
GO:0060876 biolink:NamedThing semicircular canal formation The developmental process pertaining to the initial formation of the semicircular canal from the otic vesicle. This process begins with the regionalization of the vesicle that specifies the area where the vesicles will form and continues through the process of fusion which forms the initial tubes. got7fsn_ti dph 2009-08-13T09:45:07Z biological_process owl:Class
GO:0080105 biolink:NamedThing 6-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 6-methylthiopropyl-glucosinolate = 6-methylsulfinylpropyl-glucosinolate. got7fsn_ti dhl 2009-04-23T04:28:55Z molecular_function owl:Class
GO:0034466 biolink:NamedThing chromaffin granule lumen The volume enclosed by the membrane of a chromaffin granule. got7fsn_ti cellular_component owl:Class
GO:0036423 biolink:NamedThing hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate. got7fsn_ti hexaprenyl diphosphate synthase activity|hexaprenyl pyrophosphate synthetase activity bf 2013-09-16T12:22:10Z KEGG_REACTION:R09245|EC:2.5.1.83|RHEA:27559|MetaCyc:TRANS-PENTAPRENYLTRANSFERASE-RXN molecular_function owl:Class
GO:0050796 biolink:NamedThing regulation of insulin secretion Any process that modulates the frequency, rate or extent of the regulated release of insulin. got7fsn_ti biological_process owl:Class
GO:0097390 biolink:NamedThing chemokine (C-X-C motif) ligand 12 production The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CXCL12 production pr 2012-10-23T07:57:28Z biological_process owl:Class
GO:0047022 biolink:NamedThing 7-beta-hydroxysteroid dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + a 7-beta-hydroxysteroid = NADPH + H+ + a 7-oxosteroid. got7fsn_ti NADP-dependent 7beta-hydroxysteroid dehydrogenase activity|7beta-hydroxysteroid dehydrogenase (NADP+)|NADP-dependent 7-beta-hydroxysteroid dehydrogenase activity|7beta-hydroxysteroid:NADP+ 7-oxidoreductase activity Wikipedia:7beta-hydroxysteroid_dehydrogenase_(NADP+)|EC:1.1.1.201|MetaCyc:1.1.1.201-RXN|RHEA:20233 molecular_function owl:Class
GO:0018783 biolink:NamedThing deisopropyldeethylatrazine hydrolase activity Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3. got7fsn_ti molecular_function owl:Class
GO:0102265 biolink:NamedThing tRNA-dihydrouridine47 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) <=> H+ + a uracil47 in tRNA + NAD(P)H. got7fsn_ti MetaCyc:RXN-12457|EC:1.3.1.89 molecular_function owl:Class
GO:0043479 biolink:NamedThing pigment accumulation in tissues in response to UV light The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus. got7fsn_ti biological_process owl:Class
GO:0070995 biolink:NamedThing NADPH oxidation A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP. got7fsn_ti NADPH dehydrogenation|reduced NADP oxidation|reduced nicotinamide adenine dinucleotide phosphate oxidation|NADP (reduced) dehydrogenation|reduced nicotinamide adenine dinucleotide phosphate dehydrogenation|NADP (reduced) oxidation|reduced NADP dehydrogenation mah 2009-11-03T12:02:15Z biological_process owl:Class
GO:0000380 biolink:NamedThing alternative mRNA splicing, via spliceosome The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. got7fsn_ti alternative nuclear mRNA splicing, via spliceosome|splice site selection Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals. biological_process owl:Class
GO:0032037 biolink:NamedThing myosin I heavy chain binding Binding to a heavy chain of a myosin I complex. got7fsn_ti molecular_function owl:Class
GO:0080100 biolink:NamedThing L-glutamine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-glutamine + 2-oxoglutarate = 2-oxoglutaramate + L-glutamate. got7fsn_ti L-glutamine:alpha-ketoglutarate aminotransferase activity This reaction falls within the larger set of reactions associated with EC:2.6.1.50 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.50). dhl 2009-04-23T03:56:16Z EC:2.6.1.50 molecular_function owl:Class
GO:0090512 biolink:NamedThing eisosome membrane domain/MCC A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins. got7fsn_ti tb 2012-12-07T17:00:19Z cellular_component owl:Class
GO:0047327 biolink:NamedThing glycerol-3-phosphate-glucose phosphotransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + D-glucose = D-glucose 6-phosphate + glycerol. got7fsn_ti sn-glycerol-3-phosphate:D-glucose 6-phosphotransferase activity EC:2.7.1.142|MetaCyc:2.7.1.142-RXN|RHEA:21288|KEGG_REACTION:R00850 molecular_function owl:Class
GO:0110100 biolink:NamedThing spindle pole body separation The release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. kmv 2018-03-06T15:09:28Z biological_process owl:Class
GO:0070140 biolink:NamedThing SUMO-specific isopeptidase activity Catalysis of the hydrolysis of an isopeptide bond between the small conjugating protein SUMO and a protein to which SUMO has been conjugated. got7fsn_ti molecular_function owl:Class
GO:0047907 biolink:NamedThing furylfuramide isomerase activity Catalysis of the reaction: (E)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide = (Z)-2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide. got7fsn_ti 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity RHEA:21848|KEGG_REACTION:R04538|EC:5.2.1.6|MetaCyc:FURYLFURAMIDE-ISOMERASE-RXN molecular_function owl:Class
GO:0005497 biolink:NamedThing androgen binding Binding to an androgen, a male sex hormone. got7fsn_ti molecular_function owl:Class
GO:0106286 biolink:NamedThing (E)-caffeate-CoA ligase activity Catalysis of the reaction: (E)-caffeate + ATP + CoA = (E)-caffeoyl-CoA + AMP + diphosphate. got7fsn_ti hjd 2020-07-30T14:26:08Z RHEA:36299 molecular_function owl:Class
GO:0018172 biolink:NamedThing peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine. got7fsn_ti peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine|peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine|peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine RESID:AA0263 biological_process owl:Class
GO:0018336 biolink:NamedThing peptidyl-tyrosine hydroxylation The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine. got7fsn_ti biological_process owl:Class
GO:0031700 biolink:NamedThing adrenomedullin receptor binding Binding to an adrenomedullin receptor. got7fsn_ti adrenomedullin receptor ligand molecular_function owl:Class
GO:0102666 biolink:NamedThing indole-3-acetyl-beta-4-D-glucose hydrolase activity Catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose. got7fsn_ti MetaCyc:RXN-3164 molecular_function owl:Class
GO:0050416 biolink:NamedThing formimidoylglutamate deiminase activity Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3. got7fsn_ti formiminoglutamic iminohydrolase activity|formiminoglutamate deiminase activity|N-formimidoyl-L-glutamate iminohydrolase activity RHEA:22832|EC:3.5.3.13|MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN molecular_function owl:Class
GO:0120170 biolink:NamedThing intraciliary transport particle B binding Binding to an intraciliary transport particle B (IFT B) complex. got7fsn_ti IFT B complex binding|intraflagellar transport complex B binding|intraciliary transport complex B binding|intraflagellar transport particle B binding krc 2018-05-11T22:28:11Z molecular_function owl:Class
GO:0035361 biolink:NamedThing Cul8-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins. got7fsn_ti bf 2010-03-05T02:41:12Z cellular_component owl:Class
GO:0060422 biolink:NamedThing peptidyl-dipeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a peptidyl-dipeptidase. Peptidyl-dipeptidase activity catalyzes the release of C-terminal dipeptides from a polypeptide chain. got7fsn_ti Wikipedia:ACE_inhibitor molecular_function owl:Class
GO:0030414 biolink:NamedThing peptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. got7fsn_ti protease inhibitor activity molecular_function owl:Class
GO:0019506 biolink:NamedThing phenylmercury acetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group. got7fsn_ti phenylmercury acetate breakdown|phenylmercury acetate catabolism|phenylmercury acetate degradation MetaCyc:P641-PWY biological_process owl:Class
GO:0005223 biolink:NamedThing intracellular cGMP-activated cation channel activity Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. got7fsn_ti intracellular cGMP activated cation channel activity molecular_function owl:Class
GO:0046548 biolink:NamedThing retinal rod cell development Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light. got7fsn_ti biological_process owl:Class
GO:0042462 biolink:NamedThing eye photoreceptor cell development Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve. got7fsn_ti biological_process owl:Class
GO:0001852 biolink:NamedThing complement component iC3b binding Binding to a iC3b product of the complement cascade. got7fsn_ti molecular_function owl:Class
GO:0051575 biolink:NamedThing 5'-deoxyribose-5-phosphate lyase activity Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. got7fsn_ti dRPase activity|dRP lyase activity|5'-deoxyribose phosphate activity molecular_function owl:Class
GO:0039560 biolink:NamedThing suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity Any process in which a virus stops, prevents, or reduces a JAK1-STAT signaling cascade in a host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes. got7fsn_ti inhibition of host IRF9 by virus|suppression by virus of host IRF9 activity|inhibition of host interferon regulatory factor-9 by virus|suppression by virus of host interferon regulatory factor 9 activity https://github.com/geneontology/go-ontology/issues/21986 This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. bf 2012-03-09T04:42:08Z biological_process owl:Class
GO:0097388 biolink:NamedThing chemokine (C-C motif) ligand 19 production The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti MIP-3-beta production|CCL19 production|EBI1 ligand chemokine production|macrophage inflammatory protein-3-beta production|ELC production pr 2012-10-23T07:54:10Z biological_process owl:Class
GO:0035769 biolink:NamedThing B cell chemotaxis across high endothelial venule The movement of a B cell to cross a high endothelial venule in response to an external stimulus. got7fsn_ti B-cell chemotaxis across high endothelial venule bf 2011-04-01T10:48:59Z biological_process owl:Class
GO:0002518 biolink:NamedThing lymphocyte chemotaxis across high endothelial venule The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0047821 biolink:NamedThing D-glutamate oxidase activity Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2. got7fsn_ti D-glutamic acid oxidase activity|D-glutamate:oxygen oxidoreductase (deaminating)|D-glutamic oxidase activity RHEA:10028|EC:1.4.3.7|KEGG_REACTION:R00279|MetaCyc:D-GLUTAMATE-OXIDASE-RXN molecular_function owl:Class
GO:0009395 biolink:NamedThing phospholipid catabolic process The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester. got7fsn_ti phospholipid breakdown|phospholipid catabolism|phospholipid degradation biological_process owl:Class
GO:0004049 biolink:NamedThing anthranilate synthase activity Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. got7fsn_ti chorismate pyruvate-lyase (amino-accepting) activity|anthranilate synthetase activity EC:4.1.3.27|RHEA:21732|MetaCyc:ANTHRANSYN-RXN molecular_function owl:Class
GO:0044636 biolink:NamedThing envenomation resulting in modulation of complement activation, classical pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism. got7fsn_ti jl 2012-07-05T04:40:57Z biological_process owl:Class
GO:0098758 biolink:NamedThing response to interleukin-8 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus. got7fsn_ti response to IL-8 biological_process owl:Class
GO:0102068 biolink:NamedThing alpha-humulene 10-hydroxylase activity Catalysis of the reaction: (1E,4E,8E)-alpha-humulene + NADPH + O2 + H+ <=> 10-hydroxy-alpha-humulene + NADP + H2O. got7fsn_ti EC:1.14.14.113|MetaCyc:RXN-10628|RHEA:32491 molecular_function owl:Class
GO:0070644 biolink:NamedThing vitamin D response element binding Binding to a vitamin D response element (VDRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. got7fsn_ti VDRE binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. mah 2009-05-08T04:23:44Z molecular_function owl:Class
GO:0102070 biolink:NamedThing 18-hydroxyoleate peroxygenase activity Catalysis of the reaction: 18-hydroxyoleate + a lipid hydroperoxide <=> 9,10-epoxy-18-hydroxystearate + a lipid alcohol. got7fsn_ti MetaCyc:RXN-1064|EC:1.11.2.3 molecular_function owl:Class
GO:1901656 biolink:NamedThing glycoside transport The directed movement of a glycoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti pr 2012-11-20T11:59:16Z biological_process owl:Class
GO:0052933 biolink:NamedThing alcohol dehydrogenase (cytochrome c(L)) activity Catalysis of the reaction: 2 [Fe(III)cytochrome cL] + a primary alcohol = 2 [Fe(II)cytochrome cL] + an aldehyde + 2 H+. got7fsn_ti 2-chloroethanol cytochrome-c oxidoreductase activity|methanol ferricytochrome-c oxidoreductase activity|ethanol cytochrome-c oxidoreductase activity|alcohol:cytochrome c(L) oxidoreductase activity|methanol dehydrogenase activity https://github.com/geneontology/go-ontology/issues/21412 GO:0052932|GO:0052930|GO:0052931 MetaCyc:RXN-11332|MetaCyc:RXN-2861|KEGG_REACTION:R01146|KEGG_REACTION:R09128|EC:1.1.2.7|RHEA:51004|KEGG_REACTION:R09127 molecular_function owl:Class
GO:0034564 biolink:NamedThing 4,4'-dihydroxy-alpha-methylstilbene dioxygenase activity Catalysis of the reaction: 4,4'-dihydroxy-alpha-methylstilbene + O2 = 4-hydroxybenzaldehyde + 4-hydroxyacetophenone + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0866 molecular_function owl:Class
GO:0050915 biolink:NamedThing sensory perception of sour taste The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti sour taste perception biological_process owl:Class
GO:0008910 biolink:NamedThing kanamycin kinase activity Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate. got7fsn_ti neomycin-kanamycin phosphotransferase activity|APH(3') activity|kanamycin kinase (phosphorylating)|neomycin phosphotransferase activity|ATP:kanamycin 3'-O-phosphotransferase activity|aminoglycoside 3'-phosphotransferase activity MetaCyc:KANAMYCIN-KINASE-RXN|KEGG_REACTION:R01888|EC:2.7.1.95|RHEA:24256 molecular_function owl:Class
GO:0001962 biolink:NamedThing alpha-1,3-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage. got7fsn_ti isoglobotriaosylceramide synthase molecular_function owl:Class
GO:0048174 biolink:NamedThing negative regulation of short-term neuronal synaptic plasticity A process that decreases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. got7fsn_ti down-regulation of short-term neuronal synaptic plasticity|down regulation of short-term neuronal synaptic plasticity|inhibition of short-term neuronal synaptic plasticity|downregulation of short-term neuronal synaptic plasticity Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:0018288 biolink:NamedThing iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide RESID:AA0140 biological_process owl:Class
GO:0018872 biolink:NamedThing arsonoacetate metabolic process The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides. got7fsn_ti arsonoacetate metabolism UM-BBD_pathwayID:ara biological_process owl:Class
GO:0010311 biolink:NamedThing lateral root formation The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper. got7fsn_ti lateral root primordium development GO:0010386 biological_process owl:Class
GO:0106328 biolink:NamedThing acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H(+) + UDP. got7fsn_ti hjd 2020-09-30T13:46:37Z EC:2.4.1.147|RHEA:46884 molecular_function owl:Class
GO:0005992 biolink:NamedThing trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. got7fsn_ti trehalose formation|trehalose biosynthesis|trehalose anabolism|mykose biosynthesis|trehalose synthesis|mycose biosynthetic process|mykose biosynthetic process|mycose biosynthesis MetaCyc:TREHALOSESYN-PWY|MetaCyc:PWY-881|MetaCyc:TRESYN-PWY biological_process owl:Class
GO:0004803 biolink:NamedThing transposase activity Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. got7fsn_ti P-element encoded transposase activity GO:0004804 molecular_function owl:Class
GO:1903983 biolink:NamedThing positive regulation of microvillus length A process that increases the length of a microvillus. got7fsn_ti up regulation of regulation of microvillus length|upregulation of regulation of microvillus length|up-regulation of regulation of microvillus length|activation of regulation of microvillus length als 2015-03-03T13:23:58Z biological_process owl:Class
GO:0032532 biolink:NamedThing regulation of microvillus length A process that modulates the length of a microvillus. got7fsn_ti biological_process owl:Class
GO:0017168 biolink:NamedThing 5-oxoprolinase (ATP-hydrolyzing) activity Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate. got7fsn_ti oxoprolinase activity|pyroglutamic hydrolase activity|pyroglutamase (ATP-hydrolysing)|L-pyroglutamate hydrolase activity|5-oxo-L-prolinase activity|5-oxoprolinase activity|5-OPase activity|5-oxo-L-proline amidohydrolase (ATP-hydrolysing)|pyroglutamate hydrolase activity|pyroglutamase activity|pyroglutamase (ATP-hydrolyzing) activity|5-oxoprolinase (ATP-hydrolysing) RHEA:10348|Wikipedia:5-oxoprolinase_(ATP-hydrolysing)|Reactome:R-HSA-5603208|Reactome:R-HSA-1247935|KEGG_REACTION:R00251|EC:3.5.2.9|MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN molecular_function owl:Class
GO:0045095 biolink:NamedThing keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. got7fsn_ti basic/neutral keratin|acidic keratin cellular_component owl:Class
GO:0005882 biolink:NamedThing intermediate filament A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins. got7fsn_ti type II intermediate filament associated protein|intermediate filament associated protein|type I intermediate filament associated protein NIF_Subcellular:sao952483289|Wikipedia:Intermediate_filament|FMA:63851 cellular_component owl:Class
GO:0097582 biolink:NamedThing dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p. got7fsn_ti Pmt1p-Pmt2p complex pr 2014-03-02T18:13:34Z cellular_component owl:Class
GO:0010598 biolink:NamedThing NAD(P)H dehydrogenase complex (plastoquinone) Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool. got7fsn_ti cellular_component owl:Class
GO:0007381 biolink:NamedThing specification of segmental identity, labial segment The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'. biological_process owl:Class
GO:0080193 biolink:NamedThing diffuse secondary thickening Lateral growth of the older parts of a stem that occurs when the central parenchyma cells and the not yet fully differentiated fiber cells of the bundle sheaths continue to undergo cell division and expansion for a long period of time, leading to an increase in girth of the stem. got7fsn_ti Occurs in the stems (PO:0009047) of some Arecaceae (palms). dhl 2012-12-06T15:57:50Z biological_process owl:Class
GO:0052899 biolink:NamedThing N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity Catalysis of the reaction: H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine. got7fsn_ti N(1)-acetylpolyamine oxidase activity|polyamine oxidase activity MetaCyc:RXN-10460|RHEA:25868|EC:1.5.3.13 molecular_function owl:Class
GO:0043490 biolink:NamedThing malate-aspartate shuttle The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle. got7fsn_ti malate/aspartate shuttle|malate aspartate shuttle|malate:aspartate shuttle Wikipedia:Malate-aspartate_shuttle biological_process owl:Class
GO:1990542 biolink:NamedThing mitochondrial transmembrane transport The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion. got7fsn_ti vw 2014-11-19T11:19:21Z biological_process owl:Class
GO:1901337 biolink:NamedThing thioester transport The directed movement of a thioester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti bf 2012-09-03T13:14:44Z biological_process owl:Class
GO:0102442 biolink:NamedThing syringetin 3-O-methyltransferase activity Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 3,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13920 molecular_function owl:Class
GO:0039634 biolink:NamedThing killing by virus of host cell during superinfection exclusion The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus. got7fsn_ti killing by virus of host cells during superinfection exclusion|Rex exclusion|killing by virus of host cells involved in superinfection exclusion bf 2012-08-10T14:46:03Z biological_process owl:Class
GO:0098603 biolink:NamedThing selenol Se-methyltransferase activity Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine. got7fsn_ti Reactome:R-HSA-2408544 molecular_function owl:Class
GO:0043035 biolink:NamedThing chromatin insulator sequence binding Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription. got7fsn_ti molecular_function owl:Class
GO:0043593 biolink:NamedThing endospore coat The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination. got7fsn_ti cellular_component owl:Class
GO:0035589 biolink:NamedThing G protein-coupled purinergic nucleotide receptor signaling pathway The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. got7fsn_ti P2Y receptor signaling pathway|G-protein coupled purinergic nucleotide receptor signaling pathway|G-protein coupled purinergic nucleotide receptor signalling pathway bf 2010-10-22T11:18:59Z biological_process owl:Class
GO:0090520 biolink:NamedThing sphingolipid mediated signaling pathway A series of molecular signals mediated by a sphingolipid. got7fsn_ti ceramide signaling pathway|sphingolipid mediated signal transduction|sphingosine signaling pathway|ceramide 1-phosphate signaling pathway|sphingolipid signaling pathway|sphingolipid-mediated signaling pathway tb 2013-01-08T09:30:54Z biological_process owl:Class
GO:0043162 biolink:NamedThing ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. got7fsn_ti ubiquitin-dependent protein degradation via the multivesicular body pathway|ubiquitin-dependent protein catabolic process via the MVB pathway|ubiquitin-dependent protein catabolism via the MVB pathway|ubiquitin-dependent protein breakdown via the multivesicular body pathway biological_process owl:Class
GO:0006511 biolink:NamedThing ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. got7fsn_ti protein ubiquitination during ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolism|protein ubiquitylation during ubiquitin-dependent protein catabolism|ubiquitin-dependent proteolysis|protein ubiquitination during ubiquitin-dependent protein catabolism|myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process|protein degradation tagging activity|protein ubiquitination during ubiquitin-dependent protein breakdown|ubiquitin-dependent protein breakdown|protein ubiquitinylation during ubiquitin-dependent protein catabolic process|protein ubiquitination during ubiquitin-dependent protein degradation|protein ubiquitylation during ubiquitin-dependent protein catabolic process|protein ubiquitinylation during ubiquitin-dependent protein catabolism|myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown|ubiquitin-dependent protein degradation|myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation GO:0043432|GO:0042787 biological_process owl:Class
GO:0120193 biolink:NamedThing tight junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a tight junction. A tight junction seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. got7fsn_ti occluding cell junction organization|occluding junction organization krc 2018-08-14T23:05:40Z biological_process owl:Class
GO:0045216 biolink:NamedThing cell-cell junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells. got7fsn_ti cell-cell junction organisation|cell-cell junction biogenesis|intercellular junction assembly and maintenance|cell-cell junction assembly and maintenance biological_process owl:Class
GO:0001779 biolink:NamedThing natural killer cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. got7fsn_ti NK cell differentiation|natural killer cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0052730 biolink:NamedThing sarcosine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + sarcosine = S-adenosyl-L-homocysteine + N,N-dimethylglycine. got7fsn_ti SDMT|S-adenosyl-L-methionine:N,N-sarcosine N-methyltransferase activity ai 2011-08-16T03:45:39Z MetaCyc:RXN-9679|KEGG_REACTION:R07243|EC:2.1.1.156|EC:2.1.1.157|EC:2.1.1.162|MetaCyc:R481-RXN|MetaCyc:RXN-7042|RHEA:15453 molecular_function owl:Class
GO:0045552 biolink:NamedThing dihydrokaempferol 4-reductase activity Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. got7fsn_ti dihydroflavonol 4-reductase activity|NADPH-dihydromyricetin reductase activity|dihydromyricetin reductase activity|dihydroflavanol 4-reductase activity|dihydroquercetin reductase activity|cis-3,4-leucopelargonidin:NADP+ 4-oxidoreductase activity RHEA:23016|MetaCyc:DIHYDROKAEMPFEROL-4-REDUCTASE-RXN|EC:1.1.1.219 molecular_function owl:Class
GO:0044608 biolink:NamedThing peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester. got7fsn_ti peptidyl-threonine esterification jl 2012-05-30T02:47:57Z RESID:AA0507 biological_process owl:Class
GO:0006481 biolink:NamedThing C-terminal protein methylation The methylation of the C-terminal amino acid of a protein. got7fsn_ti C-terminal protein amino acid methylation biological_process owl:Class
GO:0030924 biolink:NamedThing manganese incorporation into metallo-oxygen cluster The incorporation of manganese into a metallo-oxygen cluster. got7fsn_ti biological_process owl:Class
GO:0030923 biolink:NamedThing metal incorporation into metallo-oxygen cluster The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate. got7fsn_ti biological_process owl:Class
GO:0061971 biolink:NamedThing replacement bone morphogenesis The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone. got7fsn_ti dph 2018-02-12T18:10:59Z biological_process owl:Class
GO:0052688 biolink:NamedThing (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + AMP + diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. got7fsn_ti 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity KEGG_REACTION:R06515 molecular_function owl:Class
GO:0047588 biolink:NamedThing 5-aminopentanamidase activity Catalysis of the reaction: 5-aminopentanamide + H2O = 5-aminopentanoate + NH3. got7fsn_ti 5-aminonorvaleramidase activity|5-aminopentanamide amidohydrolase activity|5-aminovaleramidase activity MetaCyc:5-AMINOPENTANAMIDASE-RXN|RHEA:15677|EC:3.5.1.30 molecular_function owl:Class
GO:0004592 biolink:NamedThing pantoate-beta-alanine ligase activity Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. got7fsn_ti (R)-pantoate:beta-alanine ligase (AMP-forming)|D-pantoate:beta-alanine ligase (AMP-forming)|pantothenate synthetase activity|pantoate-activating enzyme activity|pantoic-activating enzyme activity RHEA:10912|MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN|EC:6.3.2.1 molecular_function owl:Class
GO:0102296 biolink:NamedThing 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity Catalysis of the reaction: (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O <=> 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+. got7fsn_ti RHEA:32035|MetaCyc:RXN-12718|EC:3.7.1.17 molecular_function owl:Class
GO:0010349 biolink:NamedThing L-galactose dehydrogenase activity Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+. got7fsn_ti L-galactose 1-dehydrogenase activity https://github.com/geneontology/go-ontology/issues/3975|https://github.com/geneontology/go-ontology/issues/21831 RHEA:31559|MetaCyc:RXN-1884|EC:1.1.1.316 molecular_function owl:Class
GO:0101027 biolink:NamedThing optical nerve axon regeneration The regrowth of axons of the optical nerve following their loss or damage. got7fsn_ti biological_process owl:Class
GO:0002752 biolink:NamedThing cell surface pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. got7fsn_ti cell surface PRR signaling pathway|cell surface pathogen receptor signaling pathway|cell surface PAMP receptor signaling pathway|cell surface pattern recognition receptor signalling pathway https://github.com/geneontology/go-ontology/issues/18588 biological_process owl:Class
GO:0102689 biolink:NamedThing UDP-glucose:isopentenyladenine 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine <=> H+ + 7-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP. got7fsn_ti MetaCyc:RXN-4727 molecular_function owl:Class
GO:0032614 biolink:NamedThing interleukin-11 production The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-11 production|interleukin-11 biosynthetic process|interleukin-11 secretion GO:0072609|GO:0042230 biological_process owl:Class
GO:0043244 biolink:NamedThing regulation of protein-containing complex disassembly Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. got7fsn_ti regulation of protein complex disassembly biological_process owl:Class
GO:0022882 biolink:NamedThing protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti beta-glucoside PTS transporter activity molecular_function owl:Class
GO:0015573 biolink:NamedThing beta-glucoside transmembrane transporter activity Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. got7fsn_ti beta-glucoside permease activity GO:0015582 molecular_function owl:Class
GO:0018402 biolink:NamedThing protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. got7fsn_ti protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine RESID:AA0208 biological_process owl:Class
GO:0004484 biolink:NamedThing mRNA guanylyltransferase activity Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. got7fsn_ti protein lambda2|mRNA capping enzyme activity|GTP--RNA guanylyltransferase activity|messenger RNA guanylyltransferase activity|GTP:mRNA guanylyltransferase activity Reactome:R-HSA-77083|EC:2.7.7.50|RHEA:54592|MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN|Reactome:R-HSA-77081 molecular_function owl:Class
GO:0031817 biolink:NamedThing P2Y8 nucleotide receptor binding Binding to a P2Y8 nucleotide receptor. got7fsn_ti P2Y8 nucleotide receptor ligand molecular_function owl:Class
GO:0034382 biolink:NamedThing chylomicron remnant clearance The process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded. got7fsn_ti biological_process owl:Class
GO:0071830 biolink:NamedThing triglyceride-rich lipoprotein particle clearance The process in which a triglyceride-rich lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. got7fsn_ti mah 2010-09-08T11:23:55Z biological_process owl:Class
GO:0002681 biolink:NamedThing somatic recombination of T cell receptor gene segments The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments. got7fsn_ti somatic recombination of TCR gene segments biological_process owl:Class
GO:0047908 biolink:NamedThing fusarinine-C ornithinesterase activity Catalysis of the reaction: N5-acyl-L-ornithine ester + H2O = N5-acyl-L-ornithine + an alcohol. got7fsn_ti 5-N-acyl-L-ornithine-ester hydrolase activity|N5-acyl-L-ornithine-ester hydrolase activity|ornithine esterase activity RHEA:20165|EC:3.1.1.48|MetaCyc:FUSARININE-C-ORNITHINESTERASE-RXN molecular_function owl:Class
GO:0102478 biolink:NamedThing beta-L-arabinofuranosidase activity Catalysis of the reaction: beta-L-arabinofuranosyl-(1->2)-beta-L-arabinofuranose + H2O = 2 beta-L-arabinofuranose. got7fsn_ti RHEA:36051|EC:3.2.1.185|MetaCyc:RXN-14089 molecular_function owl:Class
GO:0019373 biolink:NamedThing epoxygenase P450 pathway The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids. got7fsn_ti biological_process owl:Class
GO:0099624 biolink:NamedThing atrial cardiac muscle cell membrane repolarization The process in which ions are transported across the plasma membrane of an atrial cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. got7fsn_ti biological_process owl:Class
GO:0102383 biolink:NamedThing steviol 19-O glucosyltransferase activity Catalysis of the reaction: steviol + UDP-alpha-D-glucose <=> 19-O-beta-glucopyranosyl-steviol + UDP + H+. got7fsn_ti MetaCyc:RXN-13520 molecular_function owl:Class
GO:0003293 biolink:NamedThing heart valve cell differentiation The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve. got7fsn_ti dph 2009-10-20T11:06:46Z biological_process owl:Class
GO:0014025 biolink:NamedThing neural keel formation The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts. got7fsn_ti biological_process owl:Class
GO:0097297 biolink:NamedThing activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the execution phase of apoptosis. got7fsn_ti activation of effector caspase activity Note that this term should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the execution phase of apoptosis (also known as an effector caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001272 positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. pr 2012-05-02T03:23:01Z biological_process owl:Class
GO:2001272 biolink:NamedThing positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. got7fsn_ti positive regulation of effector caspase activity pr 2011-12-13T07:59:47Z biological_process owl:Class
GO:0072056 biolink:NamedThing pyramid development The process whose specific outcome is the progression of the kidney pyramids over time, from its formation to the mature structure. Kidney pyramids are the conical masses that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts. got7fsn_ti kidney pyramid development|renal medulla development|pyramids development|renal pyramid development mah 2010-01-25T04:01:36Z biological_process owl:Class
GO:0052075 biolink:NamedThing positive regulation by symbiont of host jasmonic acid-mediated defense response Any process in which a symbiont activates, maintains or increases the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti up-regulation by symbiont of host jasmonic acid-mediated defense response|induction by organism of host jasmonic acid-mediated defense response|activation by symbiont of host jasmonic acid-mediated defense response|induction by organism of host JA-mediated defense response|positive regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction|upregulation by symbiont of host jasmonic acid-mediated defense response|up regulation by symbiont of host jasmonic acid-mediated defense response|positive regulation by organism of host JA-mediated defense response|stimulation by symbiont of host jasmonic acid-mediated defense response GO:0052273 biological_process owl:Class
GO:0005314 biolink:NamedThing high-affinity glutamate transmembrane transporter activity Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high-affinity glutamate transporter activity Reactome:R-HSA-210404|Reactome:R-HSA-428015|Reactome:R-HSA-5625015|Reactome:R-HSA-5625029 molecular_function owl:Class
GO:0015370 biolink:NamedThing solute:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). got7fsn_ti proline/glycine/betaine:hydrogen/sodium symporter activity Reactome:R-HSA-8876283 molecular_function owl:Class
GO:0000243 biolink:NamedThing commitment complex A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript. got7fsn_ti mammalian spliceosomal complex E|yeast spliceosomal complex CC|mammalian spliceosomal E complex cellular_component owl:Class
GO:0004610 biolink:NamedThing phosphoacetylglucosamine mutase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. got7fsn_ti phospho-N-acetylglucosamine mutase activity|N-acetyl-D-glucosamine 1,6-phosphomutase activity|N-acetylglucosamine-phosphate mutase activity|acetylaminodeoxyglucose phosphomutase activity|acetylglucosamine phosphomutase activity|N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN|Reactome:R-HSA-446185|RHEA:23804|EC:5.4.2.3|KEGG_REACTION:R08193 molecular_function owl:Class
GO:1990209 biolink:NamedThing negative regulation by symbiont of RNA levels in host Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-09T18:09:33Z biological_process owl:Class
GO:0033846 biolink:NamedThing adenosyl-fluoride synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine. got7fsn_ti fluorinase activity|S-adenosyl-L-methionine:fluoride adenosyltransferase activity MetaCyc:2.5.1.63-RXN|RHEA:16661|EC:2.5.1.63 molecular_function owl:Class
GO:0034598 biolink:NamedThing phosphothreonine lyase activity Catalysis of the removal of the phosphate group from phosphothreonine by cleavage of the C-OP bond with the concomitant abstraction of the alpha proton, generating a double bond-containing product. got7fsn_ti molecular_function owl:Class
GO:0015826 biolink:NamedThing threonine transport The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-threonine transport biological_process owl:Class
GO:0090471 biolink:NamedThing 9,15,9'-tri-cis-zeta-carotene isomerase activity Catalysis of the reaction: 9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene. got7fsn_ti 9,15,9'-tricis-zeta-carotene cis-trans-isomerase tb 2012-09-24T16:29:49Z molecular_function owl:Class
GO:0034056 biolink:NamedThing estrogen response element binding Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. got7fsn_ti ERE binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. molecular_function owl:Class
GO:0031390 biolink:NamedThing Ctf18 RFC-like complex A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. got7fsn_ti RFC (Ctf18)|Ctf18-RLC|Ctf18-RFC cellular_component owl:Class
GO:0050158 biolink:NamedThing orotate reductase (NADPH) activity Catalysis of the reaction: (S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate. got7fsn_ti dihydro-orotic dehydrogenase activity|orotate reductase activity|L-5,6-dihydro-orotate:NAD oxidoreductase activity|(S)-dihydroorotate:NADP+ oxidoreductase activity KEGG_REACTION:R01866|RHEA:14861|EC:1.3.1.15|MetaCyc:OROTATE-REDUCTASE-NADPH-RXN molecular_function owl:Class
GO:0050589 biolink:NamedThing leucocyanidin oxygenase activity Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O. got7fsn_ti leucoanthocyanidin hydroxylase|leucoanthocyanidin dioxygenase activity|leucocyanidin,2-oxoglutarate:oxygen oxidoreductase activity|anthocyanidin synthase activity GO:0045432 EC:1.14.20.4|MetaCyc:RXN-602 molecular_function owl:Class
GO:0030369 biolink:NamedThing ICAM-3 receptor activity Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues. got7fsn_ti Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. molecular_function owl:Class
GO:0090711 biolink:NamedThing FMN hydrolase activity Catalysis of the reaction: FMN + H2O = riboflavin + phosphate. got7fsn_ti tb 2016-10-21T16:27:34Z molecular_function owl:Class
GO:0006563 biolink:NamedThing L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. got7fsn_ti L-serine metabolism biological_process owl:Class
GO:0072313 biolink:NamedThing metanephric glomerular epithelial cell development The process whose specific outcome is the progression of a metanephric glomerular epithelial cell over time, from its formation to the mature structure. Metanephric glomerular epithelial cells are specialized epithelial cells that form part of the metanephric glomerulus; there are two types, metanephric glomerular parietal epithelial cells and metanephric glomerular visceral epithelial cells. got7fsn_ti mah 2010-04-09T06:57:26Z biological_process owl:Class
GO:0033167 biolink:NamedThing ARC complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA. got7fsn_ti argonaute siRNA chaperone complex cellular_component owl:Class
GO:0004640 biolink:NamedThing phosphoribosylanthranilate isomerase activity Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. got7fsn_ti IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)|N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity|PRA isomerase activity|N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity|PRAI activity|N-(5'-phosphoribosyl)anthranilate isomerase activity MetaCyc:PRAISOM-RXN|KEGG_REACTION:R03509|RHEA:21540|EC:5.3.1.24 molecular_function owl:Class
GO:0033372 biolink:NamedThing establishment of protease localization to mast cell secretory granule The directed movement of a protease to a location within a secretory granule in a mast cell. got7fsn_ti establishment of protease localisation in mast cell secretory granule|establishment of protease localization in mast cell secretory granule biological_process owl:Class
GO:0033369 biolink:NamedThing establishment of protein localization to mast cell secretory granule The directed movement of a protein to a location within a secretory granule in a mast cell. got7fsn_ti establishment of protein localisation in mast cell secretory granule|establishment of protein localization in mast cell secretory granule biological_process owl:Class
GO:0072464 biolink:NamedThing response to meiotic spindle assembly checkpoint signaling A process that occurs in response to signals generated as a result of meiotic spindle assembly checkpoint signaling. got7fsn_ti response to signal involved in meiotic spindle assembly checkpoint|meiotic spindle assembly checkpoint effector process mah 2010-12-09T11:37:48Z biological_process owl:Class
GO:0015389 biolink:NamedThing pyrimidine- and adenine-specific:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in). got7fsn_ti molecular_function owl:Class
GO:0005345 biolink:NamedThing purine nucleobase transmembrane transporter activity Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. got7fsn_ti purine base transmembrane transporter activity|purine transmembrane transporter activity molecular_function owl:Class
GO:0090138 biolink:NamedThing regulation of actin cytoskeleton organization by cell-cell adhesion Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. got7fsn_ti regulation of actin cytoskeleton organisation by cell-cell adhesion tb 2009-12-08T02:05:00Z biological_process owl:Class
GO:0035583 biolink:NamedThing sequestering of TGFbeta in extracellular matrix Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins. got7fsn_ti negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta|sequestering of TGFbeta LLC in extracellular matrix|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta|sequestering of TGFbeta large latency complex in extracellular matrix bf 2010-10-12T03:13:29Z biological_process owl:Class
GO:0099607 biolink:NamedThing lateral attachment of mitotic spindle microtubules to kinetochore The cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate). got7fsn_ti biological_process owl:Class
GO:0051315 biolink:NamedThing attachment of mitotic spindle microtubules to kinetochore The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex as part of mitotic metaphase plate congression. got7fsn_ti attachment of spindle microtubules to mitotic chromosome|attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|mitotic bipolar attachment|attachment of spindle microtubules to kinetochore during mitosis|attachment of spindle microtubules to kinetochore involved in mitosis This class covers transient, lateral attachment to microtubules as well as stable, correctly oriented, end-on attachment (biorientation) GO:0051314 biological_process owl:Class
GO:0034950 biolink:NamedThing phenylboronic acid monooxygenase activity Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3. got7fsn_ti UM-BBD_reactionID:r1020 molecular_function owl:Class
GO:0034805 biolink:NamedThing benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1121 molecular_function owl:Class
GO:0060031 biolink:NamedThing mediolateral intercalation The interdigitation of cells along the mediolateral axis during gastrulation. got7fsn_ti biological_process owl:Class
GO:0097211 biolink:NamedThing cellular response to gonadotropin-releasing hormone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. got7fsn_ti cellular response to gonadotrophin-releasing hormone|cellular response to GnRH pr 2012-01-09T08:51:23Z biological_process owl:Class
GO:0097210 biolink:NamedThing response to gonadotropin-releasing hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. got7fsn_ti response to GnRH pr 2012-01-09T08:48:56Z biological_process owl:Class
GO:0019126 biolink:NamedThing peptidyl-serine racemization The racemization of peptidyl-serine. got7fsn_ti GO:0018090|GO:0018372 RESID:AA0195 biological_process owl:Class
GO:0006208 biolink:NamedThing pyrimidine nucleobase catabolic process The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. got7fsn_ti pyrimidine base degradation|pyrimidine base catabolic process|pyrimidine base breakdown|pyrimidine base catabolism biological_process owl:Class
GO:0009113 biolink:NamedThing purine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. got7fsn_ti purine base anabolism|purine base biosynthetic process|purine base biosynthesis|purine base synthesis|purine base formation MetaCyc:PWY-841 biological_process owl:Class
GO:0071739 biolink:NamedThing IgD immunoglobulin complex, circulating A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti IgD antibody Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0071738 biolink:NamedThing IgD immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0033921 biolink:NamedThing capsular-polysaccharide endo-1,3-alpha-galactosidase activity Catalysis of the random hydrolysis of (1->3)-alpha-D-galactosidic linkages in Aerobacter aerogenes capsular polysaccharide. got7fsn_ti polysaccharide depolymerase activity|capsular polysaccharide galactohydrolase activity|aerobacter-capsular-polysaccharide galactohydrolase activity MetaCyc:3.2.1.87-RXN|EC:3.2.1.87 molecular_function owl:Class
GO:0050265 biolink:NamedThing RNA uridylyltransferase activity Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1). got7fsn_ti TUT activity|polynucleotide uridylyltransferase activity|poly(U) polymerase activity|UTP:RNA uridylyltransferase activity|terminal uridylyltransferase activity Reactome:R-HSA-8941312|RHEA:14785|EC:2.7.7.52|MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN molecular_function owl:Class
GO:0045300 biolink:NamedThing acyl-[acyl-carrier-protein] desaturase activity Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. got7fsn_ti stearyl acyl carrier protein desaturase activity|acyl-[acyl-carrier protein] desaturase activity|stearyl-ACP desaturase activity|acyl-acyl-carrier-protein, hydrogen-donor:oxygen oxidoreductase activity|acyl-acyl-carrier-protein desaturase activity Note that this function was formerly EC:1.14.99.6. MetaCyc:1.14.19.2-RXN|MetaCyc:PWY-5147|EC:1.14.19.2 molecular_function owl:Class
GO:0097575 biolink:NamedThing lateral cell cortex The region directly beneath the plasma membrane of the lateral portion of the cell. got7fsn_ti pr 2014-02-26T13:29:22Z cellular_component owl:Class
GO:0110130 biolink:NamedThing ribitol-5-phosphatase activity Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate. got7fsn_ti kmv 2018-10-08T19:47:57Z RHEA:47648 molecular_function owl:Class
GO:0102246 biolink:NamedThing 6-amino-6-deoxyfutalosine hydrolase activity Catalysis of the reaction: aminodeoxyfutalosinate + H2O <=> dehypoxanthine futalosine + adenine. got7fsn_ti MetaCyc:RXN-12346|EC:3.2.2.30|RHEA:33079 molecular_function owl:Class
GO:0051684 biolink:NamedThing maintenance of Golgi location Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of Golgi apparatus localization|maintenance of Golgi localization|maintenance of Golgi body localization biological_process owl:Class
GO:0044812 biolink:NamedThing fermentative hydrogen production The fermentation of organic substances with a net release of hydrogen. got7fsn_ti carbohydrate fermentation jl 2013-09-18T14:09:47Z Wikipedia:Fermentative_hydrogen_production biological_process owl:Class
GO:0071491 biolink:NamedThing cellular response to red light Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti cellular response to red light stimulus mah 2009-12-18T02:19:47Z biological_process owl:Class
GO:0097392 biolink:NamedThing chemokine (C-X-C motif) ligand 16 production The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CXCL16 production pr 2012-10-23T07:59:43Z biological_process owl:Class
GO:0018043 biolink:NamedThing C-terminal peptidyl-isoleucine amidation The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0090 biological_process owl:Class
GO:0050535 biolink:NamedThing beta-primeverosidase activity Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol. got7fsn_ti 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside 6-O-(beta-D-xylosyl)-beta-D-glucohydrolase activity|b-primeverosidase activity RHEA:24480|EC:3.2.1.149|MetaCyc:3.2.1.149-RXN molecular_function owl:Class
GO:0071171 biolink:NamedThing site-specific DNA replication termination at RTS1 barrier A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching. got7fsn_ti mah 2009-11-20T01:24:41Z biological_process owl:Class
GO:0062048 biolink:NamedThing lymphotoxin complex A homo- or heterotrimeric protein containing complex consisting of alpha and beta lymphotoxin subunits in different stoichiometric combinations. got7fsn_ti lymphotoxin alpha-beta dph 2018-05-18T18:34:55Z cellular_component owl:Class
GO:0034692 biolink:NamedThing E.F.G complex A protein complex that comprises three core spliceosomal proteins, designated E, F, and G. Formation of the E.F.G complex is essential but not sufficient for the formation of a stable U1 snRNP complex. got7fsn_ti cellular_component owl:Class
GO:0061803 biolink:NamedThing posterior cell cortex The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis. got7fsn_ti dph 2016-11-06T22:55:45Z cellular_component owl:Class
GO:0045838 biolink:NamedThing positive regulation of membrane potential Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti upregulation of membrane potential|up-regulation of membrane potential|stimulation of membrane potential|elevation of membrane potential|up regulation of membrane potential|activation of membrane potential biological_process owl:Class
GO:0045857 biolink:NamedThing negative regulation of molecular function, epigenetic Any heritable epigenetic process that stops, prevents, or reduces the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. got7fsn_ti inhibition of protein activity, epigenetic|downregulation of protein activity, epigenetic|negative regulation of protein activity, epigenetic|down regulation of protein activity, epigenetic|down-regulation of protein activity, epigenetic biological_process owl:Class
GO:0102449 biolink:NamedThing kaempferol 3-O-methyltransferase activity Catalysis of the reaction: kaempferol oxoanion + S-adenosyl-L-methionine <=> 3-O-methylkaempferol + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13935 molecular_function owl:Class
GO:0009976 biolink:NamedThing tocopherol cyclase activity Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol). got7fsn_ti molecular_function owl:Class
GO:0043638 biolink:NamedThing puromycin biosynthetic process The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger. got7fsn_ti biological_process owl:Class
GO:0098818 biolink:NamedThing hyperpolarization of postsynaptic membrane A process that hyerpolarizes a postsynaptic membrane relative to its resting potential. This has an inhibitory effect on the post-synaptic cell, moving the membrane potential away from the firing threshold. got7fsn_ti biological_process owl:Class
GO:1900511 biolink:NamedThing positive regulation of pentose catabolic process to ethanol Any process that activates or increases the frequency, rate or extent of pentose catabolic process to ethanol. got7fsn_ti up-regulation of pentose catabolism to ethanol|activation of pentose catabolic process to ethanol|positive regulation of pentose catabolism to ethanol|activation of pentose catabolism to ethanol|up regulation of pentose catabolic process to ethanol|upregulation of pentose catabolism to ethanol|up-regulation of pentose catabolic process to ethanol|up regulation of pentose catabolism to ethanol|upregulation of pentose catabolic process to ethanol tt 2012-05-02T04:05:01Z biological_process owl:Class
GO:0033063 biolink:NamedThing Rad51B-Rad51C-Rad51D-XRCC2 complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof. got7fsn_ti BCDX2 complex cellular_component owl:Class
GO:0047162 biolink:NamedThing 17-O-deacetylvindoline O-acetyltransferase activity Catalysis of the reaction: (1R,9R,10S,11R,12R,19R)-12-ethyl-10,11-dihydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + acetyl-CoA = (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8-methyl-8,16-diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-2(7),3,5,13-tetraen-16-ium + CoA. got7fsn_ti acetylcoenzyme A:deacetylvindoline 4-O-acetyltransferase activity|DAT activity|acetylcoenzyme A-deacetylvindoline 4-O-acetyltransferase activity|deacetylvindoline O-acetyltransferase activity|acetyl-CoA-17-O-deacetylvindoline 17-O-acetyltransferase activity|17-O-deacetylvindoline-17-O-acetyltransferase activity|acetyl-CoA:deacetylvindoline 4-O-acetyltransferase activity|deacetylvindoline acetyltransferase activity|acetyl-CoA:17-O-deacetylvindoline 17-O-acetyltransferase activity|acetylcoenzyme A:deacetylvindoline O-acetyltransferase activity EC:2.3.1.107|MetaCyc:2.3.1.107-RXN|RHEA:24496|KEGG_REACTION:R03230 molecular_function owl:Class
GO:0048673 biolink:NamedThing collateral sprouting of intact axon in response to injury The process in which outgrowths develop from the axons of intact undamaged neurons as a result of injury to an axon. The collateral sprouts typically appear from undamaged axons in a tissue which has had part of its nerve supply removed, and they can often innervate successfully any cells that have lost some or all of their original synaptic input. got7fsn_ti biological_process owl:Class
GO:0090275 biolink:NamedThing negative regulation of somatostatin secretion Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. got7fsn_ti tb 2010-02-05T02:54:14Z biological_process owl:Class
GO:0090273 biolink:NamedThing regulation of somatostatin secretion Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. got7fsn_ti tb 2010-02-05T02:54:14Z biological_process owl:Class
GO:0120001 biolink:NamedThing apical plasma membrane urothelial plaque A scallop-shaped plaque, also referred to as an asymmetric unit membrane (AUM), found in the apical plasma membrane of urothelial superficial (umbrella) cells which form a a barrier to the passage of water and soluble toxic compounds found in urine. The plaques are thickened regions of membrane composed of uroplakin transmembrane proteins which form a crystalline array. got7fsn_ti AUM|asymmetric unit membrane https://github.com/geneontology/go-ontology/issues/12996 krc 2017-02-23T21:10:27Z cellular_component owl:Class
GO:0043554 biolink:NamedThing aerobic respiration, using arsenite as electron donor The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems. got7fsn_ti biological_process owl:Class
GO:0000979 biolink:NamedThing RNA polymerase II core promoter sequence-specific DNA binding Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. got7fsn_ti krc 2010-08-10T02:17:28Z molecular_function owl:Class
GO:0102434 biolink:NamedThing pterin-4alpha-carbinolamine dehydratase activity Catalysis of the reaction: a 10-formyltetrahydrofolate-4a-carbinolamine = H2O + a 10-formyldihydrofolate. got7fsn_ti MetaCyc:RXN-13908 molecular_function owl:Class
GO:0043124 biolink:NamedThing negative regulation of I-kappaB kinase/NF-kappaB signaling Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling. got7fsn_ti down-regulation of I-kappaB kinase/NF-kappaB cascade|down regulation of I-kappaB kinase/NF-kappaB cascade|inhibition of I-kappaB kinase/NF-kappaB cascade|downregulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of I-kappaB kinase/NF-kappaB cascade biological_process owl:Class
GO:0031517 biolink:NamedThing red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation. got7fsn_ti molecular_function owl:Class
GO:0030061 biolink:NamedThing mitochondrial crista Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria. got7fsn_ti mitochondrial cristae|cristae See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. NIF_Subcellular:sao333328131 cellular_component owl:Class
GO:0033835 biolink:NamedThing flavanone 7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity Catalysis of the reaction: UDP-L-rhamnose + a flavanone 7-O-glucoside = UDP + a flavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]. got7fsn_ti UDP-rhamnose:flavanone-7-O-glucoside-2''-O-rhamnosyltransferase activity|1->2 UDP-rhamnosyltransferase activity|UDP-L-rhamnose:flavanone-7-O-glucoside 2''-O-beta-L-rhamnosyltransferase activity MetaCyc:RXN-7759|MetaCyc:RXN-5002|EC:2.4.1.236|MetaCyc:RXN-9699|RHEA:15473|MetaCyc:RXN-5004|MetaCyc:RXN-5001 molecular_function owl:Class
GO:0102513 biolink:NamedThing delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-beta-D-glucoside + 1-O-vanilloyl-beta-D-glucose <=> delphinidin 3,7-di O-beta-D-glucoside + vanillate + H+. got7fsn_ti MetaCyc:RXN-14442 molecular_function owl:Class
GO:0010852 biolink:NamedThing cyclase inhibitor activity Decreases the activity of an enzyme that catalyzes a ring closure reaction. got7fsn_ti molecular_function owl:Class
GO:0019143 biolink:NamedThing 3-deoxy-manno-octulosonate-8-phosphatase activity Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate. got7fsn_ti 3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity MetaCyc:KDO-8PPHOSPHAT-RXN|RHEA:11500|EC:3.1.3.45|KEGG_REACTION:R03350 molecular_function owl:Class
GO:0097098 biolink:NamedThing DNA/RNA hybrid annealing activity An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops. got7fsn_ti https://github.com/geneontology/go-ontology/issues/2161 pr 2011-07-07T11:20:44Z molecular_function owl:Class
GO:0071667 biolink:NamedThing DNA/RNA hybrid binding Binding to a RNA/DNA hybrid. got7fsn_ti RNA/DNA hybrid binding mah 2010-02-15T01:51:44Z molecular_function owl:Class
GO:0008835 biolink:NamedThing diaminohydroxyphosphoribosylaminopyrimidine deaminase activity Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+). got7fsn_ti 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity|2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity|2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity GO:0008485 RHEA:21868|KEGG_REACTION:R03459|EC:3.5.4.26|MetaCyc:RIBOFLAVINSYNDEAM-RXN molecular_function owl:Class
GO:0042396 biolink:NamedThing phosphagen biosynthetic process The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. got7fsn_ti phosphagen synthesis|phosphagen formation|phosphagen anabolism|phosphagen biosynthesis biological_process owl:Class
GO:0090165 biolink:NamedThing regulation of secretion by asymmetric Golgi ribbon formation The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell. got7fsn_ti tb 2009-12-08T09:05:16Z biological_process owl:Class
GO:0051525 biolink:NamedThing NFAT protein binding Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. got7fsn_ti NFAT4 protein binding|non-calcium-regulated NFAT protein binding|NFAT1 protein binding|NFATc2 binding|NFAT2 protein binding|NFATc4 binding|NFATc1 binding|NFAT5 protein binding|NFAT binding|NFATp binding|NFATc3 binding|NFATc binding|NFATx binding|NFAT3 protein binding|nuclear factor of activated T cell protein binding GO:0051530|GO:0051528|GO:0051526|GO:0051527|GO:0051529 molecular_function owl:Class
GO:0035092 biolink:NamedThing sperm chromatin condensation The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication. got7fsn_ti biological_process owl:Class
GO:0036426 biolink:NamedThing ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP. got7fsn_ti bf 2013-09-16T13:21:01Z KEGG_REACTION:R07257|MetaCyc:2.4.1.54-RXN molecular_function owl:Class
GO:0030339 biolink:NamedThing fatty-acyl-ethyl-ester synthase activity Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol. got7fsn_ti fatty-acyl ethyl ester synthase|FAEES activity|long-chain-fatty-acyl-ethyl-ester acylhydrolase activity|FAEE synthase activity RHEA:16641|EC:3.1.1.67|MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN molecular_function owl:Class
GO:0120206 biolink:NamedThing photoreceptor distal connecting cilium The distal region of the photoreceptor connecting cilium is structurally unique to the photoreceptor and is maintained by retina-specific protein, SPATA7, and its interacting partners RPGR and RPGRIP1. It is essential for photoreceptor sensory cilium stability. got7fsn_ti DCC|photoreceptor DCC krc 2019-05-10T22:54:05Z cellular_component owl:Class
GO:0018646 biolink:NamedThing 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate. got7fsn_ti UM-BBD_reactionID:r0736|EC:1.14.13.- molecular_function owl:Class
GO:0030781 biolink:NamedThing 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline. got7fsn_ti S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity RHEA:11892|EC:2.1.1.121|MetaCyc:2.1.1.121-RXN molecular_function owl:Class
GO:0006123 biolink:NamedThing mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. got7fsn_ti complex IV (reduction of O2) biological_process owl:Class
GO:0038124 biolink:NamedThing toll-like receptor TLR6:TLR2 signaling pathway A series of molecular signals initiated by the binding of a heterodimeric TLR6:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti toll-like receptor TLR6:TLR2 signalling pathway|TLR2:TLR6 signaling pathway bf 2012-03-23T10:29:09Z biological_process owl:Class
GO:0034838 biolink:NamedThing menthone dehydrogenase activity Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+. got7fsn_ti UM-BBD_reactionID:r1183 molecular_function owl:Class
GO:0044164 biolink:NamedThing host cell cytosol The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. got7fsn_ti host cytosol jl 2009-09-04T11:03:27Z cellular_component owl:Class
GO:0070471 biolink:NamedThing uterine smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the uterus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The uterus is a muscular organ of the female mammal for containing and usually for nourishing the young during development prior to birth. got7fsn_ti myometrium contraction|myometrial contraction|myometrial smooth muscle contraction biological_process owl:Class
GO:0050101 biolink:NamedThing mimosinase activity Catalysis of the reaction: L-mimosine + H(2)O = 3-hydroxy-4H-pyrid-4-one + L-serine. got7fsn_ti mimosine amidohydrolase activity MetaCyc:MIMOSINASE-RXN|KEGG_REACTION:R04350|RHEA:13373|EC:3.5.1.61 molecular_function owl:Class
GO:0106265 biolink:NamedThing THPH synthase activity Catalysis of the reaction: 3 H+ + hexanoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA. got7fsn_ti polyketide syntase hjd 2020-06-02T18:05:33Z RHEA:64352 molecular_function owl:Class
GO:0002490 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent|TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway|TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway biological_process owl:Class
GO:0045040 biolink:NamedThing protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes. got7fsn_ti protein import into mitochondrial outer membrane|mitochondrial outer membrane protein import|protein transport into mitochondrial outer membrane biological_process owl:Class
GO:0003994 biolink:NamedThing aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. got7fsn_ti aconitase activity|citrate(isocitrate) hydro-lyase activity|citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|cis-aconitase activity|citrate hydro-lyase activity This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'. Reactome:R-HSA-70971|Reactome:R-HSA-5690911|EC:4.2.1.3|RHEA:10336|Reactome:R-HSA-450975 molecular_function owl:Class
GO:0047342 biolink:NamedThing galactose-1-phosphate thymidylyltransferase activity Catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose. got7fsn_ti dTDP-galactose pyrophosphorylase activity|dTDP galactose pyrophosphorylase activity|thymidine diphosphogalactose pyrophosphorylase activity|dTDP-galactose diphosphorylase activity|galactose 1-phosphate thymidylyl transferase activity|thymidine triphosphate:alpha-D-galactose 1-phosphate thymidylyltransferase activity|dTTP:alpha-D-galactose-1-phosphate thymidylyltransferase activity EC:2.7.7.32|MetaCyc:2.7.7.32-RXN|KEGG_REACTION:R02329|RHEA:17165 molecular_function owl:Class
GO:0003688 biolink:NamedThing DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. got7fsn_ti ARS binding molecular_function owl:Class
GO:0102309 biolink:NamedThing dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity Catalysis of the reaction: dTDP-D-oliose + NADP <=> dTDP-4-dehydro-2,6-dideoxy-D-glucose + NADPH + H+. got7fsn_ti MetaCyc:RXN-12930 molecular_function owl:Class
GO:0010452 biolink:NamedThing histone H3-K36 methylation The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone. got7fsn_ti histone H3 K36 methylation|histone lysine H3 K36 methylation|histone H3K36me biological_process owl:Class
GO:0071816 biolink:NamedThing tail-anchored membrane protein insertion into ER membrane A process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region. got7fsn_ti protein insertion of tail-anchored membrane proteins into ER membrane|type II transmembrane protein insertion into ER membrane|tail-anchored membrane protein insertion into endoplasmic reticulum membrane mah 2010-09-06T04:55:16Z biological_process owl:Class
GO:0007545 biolink:NamedThing processes downstream of sex determination signal The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways. got7fsn_ti biological_process owl:Class
GO:0046284 biolink:NamedThing anthocyanin-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. got7fsn_ti anthocyanin catabolic process|anthocyanin breakdown|anthocyanin degradation|anthocyanin catabolism biological_process owl:Class
GO:0070773 biolink:NamedThing protein-N-terminal glutamine amidohydrolase activity Catalysis of the reaction: protein-N-terminal-L-glutamine + H2O = protein-N-terminal-L-glutamate + NH3. This reaction is the deamidation of an N-terminal glutamine residue of a protein. got7fsn_ti NtQ-amidase activity mah 2009-06-30T11:34:08Z molecular_function owl:Class
GO:0005611 biolink:NamedThing laminin-6 complex A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains. got7fsn_ti laminin-311 complex|laminin-6A complex cellular_component owl:Class
GO:0034738 biolink:NamedThing lanosterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + lanosterol = CoA + lanosterol ester. got7fsn_ti molecular_function owl:Class
GO:0097627 biolink:NamedThing high-affinity L-ornithine transmembrane transporter activity Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity L-ornithine transmembrane transporter activity pr 2014-08-20T14:26:33Z molecular_function owl:Class
GO:0000064 biolink:NamedThing L-ornithine transmembrane transporter activity Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. got7fsn_ti histidine/arginine/lysine/ornithine porter activity|L-ornithine transporter activity Reactome:R-HSA-70634 molecular_function owl:Class
GO:0050526 biolink:NamedThing poly(3-hydroxybutyrate) depolymerase activity Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5. got7fsn_ti poly(HASCL) depolymerase activity|poly(3HB) depolymerase activity|PHB depolymerase activity|poly(HA(SCL)) depolymerase activity|poly[(R)-3-hydroxybutyrate] hydrolase activity|poly(HA) depolymerase activity|poly[(R)-hydroxyalkanoic acid] depolymerase|poly((R)-hydroxyalkanoic acid) depolymerase activity EC:3.1.1.75|MetaCyc:3.1.1.75-RXN|RHEA:11248 molecular_function owl:Class
GO:0034267 biolink:NamedThing discadenine metabolic process The chemical reactions and pathways involving discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. got7fsn_ti discadenine metabolism biological_process owl:Class
GO:0001647 biolink:NamedThing G protein-coupled cytokinin receptor activity Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti cytokinin receptor activity, G-protein coupled|G protein coupled cytokinin receptor activity|G-protein coupled cytokinin receptor activity molecular_function owl:Class
GO:0102084 biolink:NamedThing L-dopa O-methyltransferase activity Catalysis of the reaction: L-dopa + S-adenosyl-L-methionine <=> 3-O-methyldopa + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-10870|EC:2.1.1.6 molecular_function owl:Class
GO:0004110 biolink:NamedThing corticosteroid side-chain-isomerase activity Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al. got7fsn_ti 11-deoxycorticosterone aldose-ketose-isomerase activity|11-deoxycorticosterone ketol-isomerase activity KEGG_REACTION:R04165|RHEA:17861|EC:5.3.1.21|MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN molecular_function owl:Class
GO:0033830 biolink:NamedThing Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline. got7fsn_ti UDP-GlcNAc:Skp1-hydroxyproline GlcNAc-transferase activity|UDP-N-acetyl-D-glucosamine:Skp1-protein-hydroxyproline N-acetyl-D-glucosaminyl-transferase activity|Skp1-HyPro GlcNAc-transferase activity|UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase activity|UDP-GlcNAc:hydroxyproline polypeptide GlcNAc-transferase activity EC:2.4.1.229|RHEA:17841 molecular_function owl:Class
GO:0018138 biolink:NamedThing peptide cross-linking via L-serine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti RESID:AA0242 biological_process owl:Class
GO:0042590 biolink:NamedThing antigen processing and presentation of exogenous peptide antigen via MHC class I The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. got7fsn_ti cross-priming|cross priming|antigen presentation, exogenous antigen via major histocompatibility complex class I|exogenous peptide antigen processing and presentation via MHC class I|cross-presentation|cross presentation|antigen presentation, exogenous antigen via MHC class I biological_process owl:Class
GO:0060527 biolink:NamedThing prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis The branching morphogenesis process in which the prostate epithelial cords branch freely to create the structure of the prostate acini. got7fsn_ti biological_process owl:Class
GO:1990871 biolink:NamedThing Vma12-Vma22 assembly complex A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p. got7fsn_ti rb 2015-09-28T19:03:28Z cellular_component owl:Class
GO:0052686 biolink:NamedThing perillic acid-CoA ligase (AMP-forming) activity Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + AMP + diphosphate + perillyl-CoA. got7fsn_ti perillic acid:CoA ligase (AMP-forming) activity|perillyl-CoA synthetase activity KEGG_REACTION:R06368 molecular_function owl:Class
GO:0006293 biolink:NamedThing nucleotide-excision repair, preincision complex stabilization The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. got7fsn_ti biological_process owl:Class
GO:0031334 biolink:NamedThing positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly. got7fsn_ti activation of protein complex assembly|up regulation of protein complex assembly|upregulation of protein complex assembly|stimulation of protein complex assembly|positive regulation of protein complex assembly|up-regulation of protein complex assembly biological_process owl:Class
GO:0102311 biolink:NamedThing 8-hydroxygeraniol dehydrogenase activity Catalysis of the reaction: (6E)-8-hydroxygeraniol + 2 NADP <=> (6E)-8-oxogeranial + 2 NADPH + 2 H+. got7fsn_ti EC:1.1.1.324|RHEA:32659|MetaCyc:RXN-12961 molecular_function owl:Class
GO:0016980 biolink:NamedThing creatinase activity Catalysis of the reaction: creatine + H(2)O = sarcosine + urea. got7fsn_ti creatine amidinohydrolase activity KEGG_REACTION:R01566|RHEA:22456|EC:3.5.3.3|MetaCyc:CREATINASE-RXN molecular_function owl:Class
GO:0031218 biolink:NamedThing arabinogalactan endo-1,4-beta-galactosidase activity Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans. got7fsn_ti endo-1,4-beta-galactanase activity|arabinogalactanase activity|arabinogalactan 4-beta-D-galactanohydrolase activity|galactanase activity MetaCyc:3.2.1.89-RXN|EC:3.2.1.89 molecular_function owl:Class
GO:0102842 biolink:NamedThing 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming) Catalysis of the reaction: 1-18:1-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:1-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti RHEA:46412|EC:1.14.19.35|MetaCyc:RXN-8303 molecular_function owl:Class
GO:0018663 biolink:NamedThing 2,6-dihydroxypyridine 3-monooxygenase activity Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+). got7fsn_ti 2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)|2,6-dihydroxypyridine oxidase activity RHEA:16917|UM-BBD_reactionID:r0479|EC:1.14.13.10|MetaCyc:1.14.13.10-RXN|KEGG_REACTION:R04130 molecular_function owl:Class
GO:0004817 biolink:NamedThing cysteine-tRNA ligase activity Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). got7fsn_ti cysteinyl-tRNA synthetase activity|cysteinyl-transfer ribonucleate synthetase activity|cysteinyl-transferRNA synthetase activity|L-cysteine:tRNACys ligase (AMP-forming)|cysteine translase activity EC:6.1.1.16|Reactome:R-HSA-379887|MetaCyc:CYSTEINE--TRNA-LIGASE-RXN|RHEA:17773|Reactome:R-HSA-380158 molecular_function owl:Class
GO:0001921 biolink:NamedThing positive regulation of receptor recycling Any process that activates or increases the frequency, rate or extent of receptor recycling. got7fsn_ti up-regulation of receptor recycling|stimulation of receptor recycling|up regulation of receptor recycling|activation of receptor recycling|upregulation of receptor recycling biological_process owl:Class
GO:0021826 biolink:NamedThing substrate-independent telencephalic tangential migration The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact. got7fsn_ti biological_process owl:Class
GO:0050193 biolink:NamedThing phosphoketolase activity Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O. got7fsn_ti D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (adding phosphate; acetyl-phosphate-forming)|xylulose-5-phosphate phosphoketolase activity|D-xylulose-5-phosphate D-glyceraldehyde-3-phosphate-lyase (phosphate-acetylating) activity MetaCyc:PHOSPHOKETOLASE-RXN|RHEA:10468|EC:4.1.2.9 molecular_function owl:Class
GO:0045222 biolink:NamedThing CD4 biosynthetic process The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions. got7fsn_ti CD4 formation|CD4 anabolism|CD4 biosynthesis|CD4 synthesis biological_process owl:Class
GO:0034687 biolink:NamedThing integrin alphaL-beta2 complex An integrin complex that comprises one alphaL subunit and one beta2 subunit. got7fsn_ti Itgal-Itgb2 complex|alphaL-beta2 integrin complex cellular_component owl:Class
GO:1990839 biolink:NamedThing response to endothelin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). got7fsn_ti sl 2015-08-27T19:37:52Z biological_process owl:Class
GO:0018904 biolink:NamedThing ether metabolic process The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds. got7fsn_ti organic ether metabolic process|ether metabolism|organic ether metabolism biological_process owl:Class
GO:0006099 biolink:NamedThing tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. got7fsn_ti TCA cycle|Krebs cycle|citric acid cycle MetaCyc:P42-PWY|Wikipedia:Tricarboxylic_acid_cycle|MetaCyc:P105-PWY|MetaCyc:TCA biological_process owl:Class
GO:0009379 biolink:NamedThing Holliday junction helicase complex A DNA helicase complex found at Holliday junctions where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA. got7fsn_ti cellular_component owl:Class
GO:1990119 biolink:NamedThing RNA helicase inhibitor activity Binds to and stops, prevents or reduces the activity of an RNA helicase. got7fsn_ti ATP-dependent RNA helicase inhibitor activity rb 2013-06-11T21:14:38Z molecular_function owl:Class
GO:0009860 biolink:NamedThing pollen tube growth Growth of pollen via tip extension of the intine wall. got7fsn_ti biological_process owl:Class
GO:0010637 biolink:NamedThing negative regulation of mitochondrial fusion Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment. got7fsn_ti biological_process owl:Class
GO:0001770 biolink:NamedThing establishment of natural killer cell polarity The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands. got7fsn_ti NK cell polarization|natural killer cell polarization|establishment of NK cell polarity biological_process owl:Class
GO:0044311 biolink:NamedThing exoneme A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte. got7fsn_ti jl 2010-02-18T03:29:56Z cellular_component owl:Class
GO:0102371 biolink:NamedThing betulin dehydrogenase activity Catalysis of the reaction: betulin + NADPH(4-) + H+ + O2 <=> betulinic aldehyde + NADP(3-) + 2 H2O. got7fsn_ti MetaCyc:RXN-13498 molecular_function owl:Class
GO:0047561 biolink:NamedThing 3-hydroxyanthranilate oxidase activity Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H(2)O(2). got7fsn_ti 3-hydroxyanthranilic acid oxidase activity|3-hydroxyanthranilate:oxygen oxidoreductase activity KEGG_REACTION:R02666|RHEA:17245|MetaCyc:3-HYDROXYANTHRANILATE-OXIDASE-RXN|EC:1.10.3.5 molecular_function owl:Class
GO:0019648 biolink:NamedThing formaldehyde assimilation via xylulose monophosphate cycle The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds. got7fsn_ti formaldehyde assimilation via xylulose-5-phosphate cycle|formaldehyde fixation cycle MetaCyc:P185-PWY biological_process owl:Class
GO:0051167 biolink:NamedThing xylulose 5-phosphate metabolic process The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway. got7fsn_ti xylulose-5-phosphate metabolic process|xylulose-5-phosphate metabolism|D-xylulose 5-phosphate metabolic process|D-xylulose-5-phosphate metabolic process|xylulose 5-phosphate metabolism|D-xylulose-5-phosphate metabolism|D-xylulose 5-phosphate metabolism biological_process owl:Class
GO:0032044 biolink:NamedThing DSIF complex A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes. got7fsn_ti 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex|Spt4-Spt5 complex|DRB sensitivity inducing factor complex|Spt5-Spt4 complex cellular_component owl:Class
GO:0030579 biolink:NamedThing ubiquitin-dependent SMAD protein catabolic process The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome. got7fsn_ti ubiquitin-dependent SMAD protein breakdown|ubiquitin-dependent SMAD protein catabolism|ubiquitin-dependent SMAD protein degradation biological_process owl:Class
GO:0044025 biolink:NamedThing histone kinase activity (H2B-S14 specific) Catalysis of the transfer of a phosphate group to the serine-14 or an equivalent residue of the N-terminal tail of histone H2B. got7fsn_ti histone-serine kinase activity (H2B-S14 specific)|histone serine kinase activity (H2B-S14 specific) molecular_function owl:Class
GO:0021776 biolink:NamedThing smoothened signaling pathway involved in spinal cord motor neuron cell fate specification The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. got7fsn_ti hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification|hh signaling pathway involved in spinal cord motor neuron cell fate specification|smoothened signalling pathway involved in spinal cord motor neuron cell fate specification biological_process owl:Class
GO:2000212 biolink:NamedThing negative regulation of glutamate metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process. got7fsn_ti negative regulation of glutamate metabolism|negative regulation of glutamic acid metabolic process|negative regulation of glutamic acid metabolism mah 2010-11-03T02:43:55Z biological_process owl:Class
GO:0016296 biolink:NamedThing palmitoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate. got7fsn_ti palmitoyl-ACP hydrolase activity|palmitoyl-[acyl-carrier protein] hydrolase activity KEGG_REACTION:R08162|EC:3.1.2.14|RHEA:41932|MetaCyc:RXN-9549 molecular_function owl:Class
GO:0035942 biolink:NamedThing dehydroepiandrosterone secretion The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system. got7fsn_ti dehydroisoandrosterone secretion|3beta-hydroxyandrost-5-en-17-one secretion|DHEA secretion bf 2011-07-25T02:13:54Z biological_process owl:Class
GO:0018450 biolink:NamedThing myrtenol dehydrogenase activity Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal. got7fsn_ti UM-BBD_reactionID:r0710 molecular_function owl:Class
GO:0036351 biolink:NamedThing histone H2A-K13 ubiquitination The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin. got7fsn_ti histone H2A ubiquitination (H2A-K13) bf 2012-09-19T11:48:05Z biological_process owl:Class
GO:0047799 biolink:NamedThing cyclopentanone monooxygenase activity Catalysis of the reaction: cyclopentanone + H(+) + NADPH + O(2) = 5-valerolactone + H(2)O + NADP(+). got7fsn_ti cyclopentanone oxygenase activity|cyclopentanone 1,2-monooxygenase activity|cyclopentanone,NADPH:oxygen oxidoreductase (5-hydroxylating, lactonizing) KEGG_REACTION:R02554|MetaCyc:CYCLOPENTANONE-MONOOXYGENASE-RXN|EC:1.14.13.16|RHEA:15737 molecular_function owl:Class
GO:0050266 biolink:NamedThing rosmarinate synthase activity Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate. got7fsn_ti 4-coumaroyl-CoA:4-hydroxyphenyllactic acid 4-coumaroyl transferase activity|caffeoyl-CoA:3-(3,4-dihydroxyphenyl)lactate 2'-O-caffeoyl-transferase activity|caffeoyl-coenzyme A:3,4-dihydroxyphenyllactic acid caffeoyltransferase activity|rosmarinic acid synthase activity EC:2.3.1.140|MetaCyc:ROSMARINATE-SYNTHASE-RXN|RHEA:22344 molecular_function owl:Class
GO:0009713 biolink:NamedThing catechol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. got7fsn_ti catechol formation|catechol biosynthetic process|catechol synthesis|catechol anabolism|catechol biosynthesis biological_process owl:Class
GO:0099511 biolink:NamedThing voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel. got7fsn_ti molecular_function owl:Class
GO:0008791 biolink:NamedThing arginine N-succinyltransferase activity Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine. got7fsn_ti succinyl-CoA:L-arginine 2-N-succinyltransferase activity|succinyl-CoA:L-arginine N2-succinyltransferase activity|AST activity|arginine and ornithine N2-succinyltransferase activity|AstA|arginine succinyltransferase activity|arginine and ornithine N(2)-succinyltransferase activity|AOST activity EC:2.3.1.109|MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN|RHEA:15185 molecular_function owl:Class
GO:0062146 biolink:NamedThing 4-chloro-allylglycine synthase activity Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+). got7fsn_ti dph 2019-09-02T16:59:30Z RHEA:59888 molecular_function owl:Class
GO:0102716 biolink:NamedThing gibberellin A28,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A28 + 2-oxoglutarate + O2 <=> (2betaOH)-gibberellin28 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-6547 molecular_function owl:Class
GO:0061837 biolink:NamedThing neuropeptide processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide. got7fsn_ti biological_process owl:Class
GO:0008688 biolink:NamedThing 3-(3-hydroxyphenyl)propionate hydroxylase activity Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O. got7fsn_ti EC:1.14.13.127|MetaCyc:MHPHYDROXY-RXN|RHEA:24785|KEGG_REACTION:R06786 molecular_function owl:Class
GO:0048529 biolink:NamedThing magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Catalysis of the reaction: magnesium protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. got7fsn_ti Mg-protoporphyrin IX monomethyl ester oxidative cyclase activity|magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating)|Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase activity EC:1.14.13.81|RHEA:33235 molecular_function owl:Class
GO:0048166 biolink:NamedThing mature follicle stage The stage in oogenesis when the antrum is swollen with follicular fluid. The ovum is ready to erupt from the ovary and is arrested at metaphase of the second meiotic division. got7fsn_ti mammalian oogenesis stage 9 biological_process owl:Class
GO:0061719 biolink:NamedThing glucose catabolic process to pyruvate utilizing ADP The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions. got7fsn_ti dph 2015-06-30T13:23:42Z MetaCyc:P341-PWY biological_process owl:Class
GO:0004479 biolink:NamedThing methionyl-tRNA formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. got7fsn_ti methionyl-tRNA Met formyltransferase activity|N-terminal peptidyl-methionine N-formylation|formylmethionyl-transfer ribonucleic synthetase activity|methionyl-transfer RNA transformylase activity|methionyl ribonucleic formyltransferase activity|mitochondrial N-terminal peptidyl-methionine N-formylation|conversion of met-tRNAf to fmet-tRNA|N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity|methionyl-tRNA transformylase activity|methionyl-transfer ribonucleic transformylase activity|methionyl-transfer ribonucleate methyltransferase activity|N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity|conversion of mitochondrial met-tRNAf to fmet-tRNA|10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity GO:0070128|GO:0001718 RHEA:24380|Reactome:R-HSA-5389841|MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN|EC:2.1.2.9 molecular_function owl:Class
GO:0072398 biolink:NamedThing signal transduction involved in cytokinesis checkpoint A signal transduction process that contributes to a cytokinesis checkpoint. got7fsn_ti mah 2010-12-08T03:22:21Z GO:0072419 biological_process owl:Class
GO:0060668 biolink:NamedThing regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling Any process that modulates the rate, frequency, or extent of salivary gland branching as a result of the transfer of information from the extracellular matrix to the epithelium of the salivary gland. got7fsn_ti regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signalling dph 2009-06-01T09:47:56Z biological_process owl:Class
GO:0016761 biolink:NamedThing cellulose synthase (GDP-forming) activity Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1). got7fsn_ti GDP-glucose-beta-D-glucan glucosyltransferase activity|cellulose synthase (guanosine diphosphate-forming) activity|guanosine diphosphoglucose-cellulose glucosyltransferase activity|guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity|GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity|GDP-glucose-cellulose glucosyltransferase activity|GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity RHEA:17797|MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN|EC:2.4.1.29 molecular_function owl:Class
GO:0098536 biolink:NamedThing deuterosome A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles. got7fsn_ti dos 2013-10-22T16:21:19Z cellular_component owl:Class
GO:0061848 biolink:NamedThing cellular response to cholecystokinin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus. got7fsn_ti biological_process owl:Class
GO:0055110 biolink:NamedThing involution involved in gastrulation with mouth forming second The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation. got7fsn_ti biological_process owl:Class
GO:0043963 biolink:NamedThing modulation by symbiont of host adenylate cyclase-mediated signal transduction Any process in which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0102463 biolink:NamedThing quercetin 3-gentiobioside 7-O-rhamnosyltransferase activity Catalysis of the reaction: quercetin-3-gentiobioside + UDP-L-rhamnose <=> quercetin 3-O-gentiobioside-7-O-rhamnoside + UDP + H+. got7fsn_ti MetaCyc:RXN-14012 molecular_function owl:Class
GO:0016438 biolink:NamedThing tRNA-queuosine beta-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine. got7fsn_ti GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity RHEA:12885|MetaCyc:2.4.1.110-RXN|EC:2.4.1.110 molecular_function owl:Class
GO:0000401 biolink:NamedThing open form four-way junction DNA binding Binding to a DNA segment containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over. got7fsn_ti open form Holliday junction binding molecular_function owl:Class
GO:0004783 biolink:NamedThing sulfite reductase (NADPH) activity Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+. got7fsn_ti hydrogen-sulfide:NADP+ oxidoreductase activity|H2S-NADP oxidoreductase activity|sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|NADPH-sulfite reductase activity|sulphite reductase (NADPH) activity|NADPH-dependent sulfite reductase activity|NADPH:sulfite reductase flavoprotein EC:1.8.1.2|MetaCyc:SULFITE-REDUCT-RXN|RHEA:13801 molecular_function owl:Class
GO:0016002 biolink:NamedThing sulfite reductase activity Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor. got7fsn_ti siroheme sulfite reductase activity|hydrogen-sulfide:(acceptor) oxidoreductase activity|assimilatory-type sulfite reductase activity|hydrogen-sulfide:acceptor oxidoreductase activity|sulphite reductase activity|assimilatory sulfite reductase activity MetaCyc:SULFITE-REDUCTASE-RXN molecular_function owl:Class
GO:0034412 biolink:NamedThing ascospore wall beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of ascospores. got7fsn_ti ascospore wall beta-glucan anabolism|ascospore wall beta-glucan formation|ascospore wall beta-glucan biosynthesis|ascospore wall beta-glucan synthesis biological_process owl:Class
GO:0034531 biolink:NamedThing 2-hydroxy-4-hydroxymethylbenzalpyruvate hydratase-aldolase activity Catalysis of the reaction: 2-hydroxy-4-hydroxymethylbenzalpyruvate + H2O = pyruvate + 4-hydroxymethylsalicylaldehyde. got7fsn_ti UM-BBD_reactionID:r0766 molecular_function owl:Class
GO:0030023 biolink:NamedThing extracellular matrix constituent conferring elasticity A component of the extracellular matrix that enables the matrix to recoil after transient stretching. got7fsn_ti elastin|core extracellular matrix|core matrisome Extracellular matrix elastin proteins may be annotated to this term. PMID:27009176, PMID:24443019 molecular_function owl:Class
GO:0005201 biolink:NamedThing extracellular matrix structural constituent The action of a molecule that contributes to the structural integrity of the extracellular matrix. got7fsn_ti extracellular matrix glycoprotein|core extracellular matrix|core matrisome Extracellular matrix glycoproteins may be annotated to this term. PMID:24443019 molecular_function owl:Class
GO:1905277 biolink:NamedThing negative regulation of epithelial tube formation Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation. got7fsn_ti down-regulation of epithelial tube formation|inhibition of epithelial tube formation|down regulation of epithelial tube formation|downregulation of epithelial tube formation An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). bhm 2016-06-20T09:35:49Z biological_process owl:Class
GO:0085030 biolink:NamedThing symbiotic process benefiting host A process carried out by symbiont gene products that enables a symbiotic interaction with a host organism, that is beneficial to the host organism. got7fsn_ti mutualism jl 2010-07-27T01:25:21Z biological_process owl:Class
GO:0004468 biolink:NamedThing lysine N-acetyltransferase activity, acting on acetyl phosphate as donor Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine. got7fsn_ti acetyl-phosphate:L-lysine N6-acetyltransferase activity|lysine N(6)-acetyltransferase activity|acetyl-phosphate:L-lysine 6-N-acetyltransferase activity|lysine N6-acetyltransferase activity|lysine acetyltransferase activity|LAT activity Reactome:R-HSA-5693001|RHEA:14417|EC:2.3.1.32|MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN|Reactome:R-HSA-5618328 molecular_function owl:Class
GO:0036498 biolink:NamedThing IRE1-mediated unfolded protein response A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. got7fsn_ti endoplasmic reticulum unfolded protein response; IRE1 signaling|inositol-requiring transmembrane kinase/endonuclease signal transduction|IRE1alpha unfolded protein response|inositol-requiring enzyme 1-mediated unfolded protein response|UPR signaling by IRE1 stress sensor|IRE1 signal transduction pathway|IRE1 signaling in response to endoplasmic reticulum stress|IRE1p unfolded protein response|ERN1-mediated unfolded protein response|IRE1 branch of UPR Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants. bf 2015-02-05T13:12:12Z biological_process owl:Class
GO:0030968 biolink:NamedThing endoplasmic reticulum unfolded protein response The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. got7fsn_ti SREBP-mediated signalling pathway|ER unfolded protein response|erUPR Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'. biological_process owl:Class
GO:0061523 biolink:NamedThing cilium disassembly A cellular process that results in the breakdown of a cilium. got7fsn_ti cilium resorption Note that we deem cilium and microtubule-based flagellum to be equivalent. dph 2013-04-18T14:59:59Z biological_process owl:Class
GO:0031796 biolink:NamedThing type 1 metabotropic GABA receptor binding Binding to a type 1 metabotropic GABA receptor. got7fsn_ti type 1 metabotropic GABA receptor ligand molecular_function owl:Class
GO:0089702 biolink:NamedThing undecaprenyl-phosphate glucose phosphotransferase activity Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol. got7fsn_ti molecular_function owl:Class
GO:0003852 biolink:NamedThing 2-isopropylmalate synthase activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+). got7fsn_ti alpha-isopropylmalate synthetase activity|isopropylmalate synthase activity|isopropylmalate synthetase activity|alpha-IPM synthetase activity|3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity|alpha-isopropylmalic synthetase activity|alpha-isopropylmalate synthase activity|acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) Note that this function was formerly EC:4.1.3.12. MetaCyc:2-ISOPROPYLMALATESYN-RXN|RHEA:21524|EC:2.3.3.13|KEGG_REACTION:R01213 molecular_function owl:Class
GO:0044231 biolink:NamedThing host cell presynaptic membrane A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. got7fsn_ti other organism pre-synaptic membrane|host cell pre-synaptic membrane|other organism presynaptic membrane jl 2009-12-08T02:11:18Z GO:0072556 cellular_component owl:Class
GO:0072679 biolink:NamedThing thymocyte migration The movement of a thymocyte through distinct intrathymic niches (e.g. medulla, cortex), where it receives a unique set of developmental cues required for T-cell development. got7fsn_ti immature T-cell migration|thymic lymphocyte migration|immature T cell migration|immature T lymphocyte migration|immature T-lymphocyte migration mah 2011-02-22T03:47:51Z biological_process owl:Class
GO:0038054 biolink:NamedThing G protein-coupled estrogen receptor activity Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G-protein coupled estrogen receptor activity bf 2011-11-29T04:29:42Z molecular_function owl:Class
GO:0043818 biolink:NamedThing precorrin-3B synthase activity Catalysis of the reaction: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B. got7fsn_ti CobG|precorrin-3A,NADH:oxygen oxidoreductase (20-hydroxylating)|precorrin-3X synthase activity EC:1.14.13.83|KEGG_REACTION:R05217|MetaCyc:R321-RXN|RHEA:17293 molecular_function owl:Class
GO:0102172 biolink:NamedThing 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 + H+ <=> 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + 2 H2O. got7fsn_ti RHEA:58860|MetaCyc:RXN-11925 molecular_function owl:Class
GO:0051970 biolink:NamedThing negative regulation of transmission of nerve impulse Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. got7fsn_ti down regulation of transmission of nerve impulse|downregulation of transmission of nerve impulse|negative regulation of conduction of nerve impulse|down-regulation of transmission of nerve impulse|inhibition of transmission of nerve impulse biological_process owl:Class
GO:0002047 biolink:NamedThing phenazine biosynthetic process The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring. got7fsn_ti dibenzo-p-diazine biosynthetic process|azophenylene biosynthesis|azophenylene biosynthetic process|dibenzopyrazine biosynthesis|acridizine biosynthesis|dibenzopyrazine biosynthetic process|acridizine biosynthetic process|dibenzo-p-diazine biosynthesis biological_process owl:Class
GO:0001561 biolink:NamedThing fatty acid alpha-oxidation A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway. got7fsn_ti MetaCyc:PWY-2501 biological_process owl:Class
GO:0009675 biolink:NamedThing high-affinity sulfate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity sulfate:proton symporter activity|high affinity sulfate:hydrogen symporter activity|high affinity sulphate:hydrogen symporter activity molecular_function owl:Class
GO:0005127 biolink:NamedThing ciliary neurotrophic factor receptor binding Binding to a ciliary neurotrophic factor receptor. got7fsn_ti ciliary neurotrophic factor|ciliary neurotrophic factor receptor ligand molecular_function owl:Class
GO:0044389 biolink:NamedThing ubiquitin-like protein ligase binding Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. got7fsn_ti E3 protein ligase binding|small conjugating protein ligase binding jl 2011-12-15T04:33:20Z molecular_function owl:Class
GO:0018363 biolink:NamedThing peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium. got7fsn_ti peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium|peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium GO:0019925 RESID:AA0280 biological_process owl:Class
GO:0021995 biolink:NamedThing neuropore closure The process of joining together the neural folds at either end of the neural tube. got7fsn_ti biological_process owl:Class
GO:0008594 biolink:NamedThing photoreceptor cell morphogenesis The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster. got7fsn_ti photoreceptor development biological_process owl:Class
GO:0007321 biolink:NamedThing sperm displacement The physical displacement of sperm stored from previous mating encounters. got7fsn_ti biological_process owl:Class
GO:0090330 biolink:NamedThing regulation of platelet aggregation Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. got7fsn_ti tb 2010-05-14T10:46:08Z biological_process owl:Class
GO:0031027 biolink:NamedThing glutamate synthase complex (NADH) A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity. got7fsn_ti cellular_component owl:Class
GO:0031026 biolink:NamedThing glutamate synthase complex A complex that possesses glutamate synthase activity. got7fsn_ti cellular_component owl:Class
GO:0043897 biolink:NamedThing glucan 1,4-alpha-maltohydrolase activity Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains. got7fsn_ti 1,4-alpha-D-glucan alpha-maltohydrolase activity|glucan-1,4-alpha-maltohydrolase activity|maltogenic alpha-amylase activity MetaCyc:3.2.1.133-RXN|EC:3.2.1.133 molecular_function owl:Class
GO:0047550 biolink:NamedThing 2-oxoadipate reductase activity Catalysis of the reaction: 2-hydroxyadipate + NAD(+) = 2-oxoadipate + H(+) + NADH. got7fsn_ti alpha-ketoadipate reductase activity|2-hydroxyadipate:NAD+ 2-oxidoreductase activity|2-ketoadipate reductase activity KEGG_REACTION:R01932|MetaCyc:2-OXOADIPATE-REDUCTASE-RXN|RHEA:14793|EC:1.1.1.172 molecular_function owl:Class
GO:0085032 biolink:NamedThing modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade Any process in which an organism modulates the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host NF-kappaB-mediated signal transduction pathway jl 2010-07-27T02:13:37Z biological_process owl:Class
GO:2000831 biolink:NamedThing regulation of steroid hormone secretion Any process that modulates the frequency, rate or extent of steroid hormone secretion. got7fsn_ti bf 2011-07-26T08:38:46Z biological_process owl:Class
GO:0070318 biolink:NamedThing positive regulation of G0 to G1 transition A cell cycle process that activates or increases the rate or extent of the transition from the G0 quiescent state to the G1 phase. got7fsn_ti biological_process owl:Class
GO:0097680 biolink:NamedThing double-strand break repair via classical nonhomologous end joining An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining). got7fsn_ti C-NHEJ|canonical nonhomologous end joining pr 2014-12-17T15:15:18Z biological_process owl:Class
GO:0046981 biolink:NamedThing beta-1,4-mannosylglycolipid beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the transfer of N-acetylglucosamine (GlcNAc) in a beta-1,3 linkage to the mannose(beta-1,4)Glc disaccharide core of glycolipids. got7fsn_ti UDP-N-acetylglucosamine:beta-D-mannosyl-glycolipid beta-1,3-N-acetylglucosaminyltransferase activity molecular_function owl:Class
GO:0036201 biolink:NamedThing ent-isokaurene C2-hydroxylase activity Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+. got7fsn_ti bf 2012-04-20T02:21:33Z EC:1.14.14.76|RHEA:56336|KEGG_REACTION:R09861 molecular_function owl:Class
GO:0097426 biolink:NamedThing glial filament An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes. got7fsn_ti pr 2012-11-07T14:59:55Z NIF_Subcellular:sao1863852493 cellular_component owl:Class
GO:0002558 biolink:NamedThing type I hypersensitivity mediated by mast cells An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. got7fsn_ti biological_process owl:Class
GO:0002448 biolink:NamedThing mast cell mediated immunity Any process involved in the carrying out of an immune response by a mast cell. got7fsn_ti biological_process owl:Class
GO:0102514 biolink:NamedThing cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose <=> cyanidin 3,7-di-O-beta-D-glucoside betaine + ferulate + H+. got7fsn_ti EC:2.4.1.300|MetaCyc:RXN-14446 molecular_function owl:Class
GO:0002503 biolink:NamedThing peptide antigen assembly with MHC class II protein complex The binding of a peptide to the antigen binding groove of an MHC class II protein complex. got7fsn_ti biological_process owl:Class
GO:0036059 biolink:NamedThing nephrocyte diaphragm assembly The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney. got7fsn_ti bf 2011-12-12T04:38:40Z biological_process owl:Class
GO:0034333 biolink:NamedThing adherens junction assembly The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments. got7fsn_ti adherens junction formation biological_process owl:Class
GO:0045860 biolink:NamedThing positive regulation of protein kinase activity Any process that activates or increases the frequency, rate or extent of protein kinase activity. got7fsn_ti up regulation of protein kinase activity|upregulation of protein kinase activity|up-regulation of protein kinase activity|stimulation of protein kinase activity biological_process owl:Class
GO:0070674 biolink:NamedThing hypoxanthine dehydrogenase activity Catalysis of the reaction: hypoxanthine + NAD+ + H2O = xanthine + NADH + H+. got7fsn_ti hypoxanthine-NAD oxidoreductase activity|hypoxanthine/NAD(+) oxidoreductase activity|hypoxanthine:NAD+ oxidoreductase activity|NAD-hypoxanthine dehydrogenase activity|hypoxanthine/NAD+ oxidoreductase activity|hypoxanthine oxidoreductase activity mah 2009-05-29T01:02:13Z molecular_function owl:Class
GO:0005858 biolink:NamedThing axonemal dynein complex A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. got7fsn_ti axonemal dynein heavy chain|axonemal dynein intermediate chain|axonemal dynein light chain|axonemal dynein intermediate light chain cellular_component owl:Class
GO:0001051 biolink:NamedThing plastid single-subunit type RNA polymerase binding Binding to a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. got7fsn_ti krc 2010-09-23T02:42:57Z molecular_function owl:Class
GO:0004802 biolink:NamedThing transketolase activity Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. got7fsn_ti sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity|fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity|glycolaldehydetransferase activity|glycoaldehyde transferase activity Reactome:R-HSA-163751|Reactome:R-HSA-71324|RHEA:10508|EC:2.2.1.1|MetaCyc:1TRANSKETO-RXN|Reactome:R-HSA-71335|Reactome:R-HSA-163741 molecular_function owl:Class
GO:0030747 biolink:NamedThing indolepyruvate C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate. got7fsn_ti indolepyruvic acid methyltransferase activity|S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity|indolepyruvate methyltransferase activity|indolepyruvate 3-methyltransferase activity|S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity RHEA:12112|EC:2.1.1.47|MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:1990576 biolink:NamedThing G protein-coupled glucose receptor activity Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G-protein coupled glucose receptor activity al 2014-12-08T03:15:12Z molecular_function owl:Class
GO:0120217 biolink:NamedThing DNA gyrase complex A bacterial type IIA topoisomerase that is unique in its function of introducing negative supercoils into DNA at the expense of ATP hydrolysis and is also capable of relaxing positive supercoils, an activity shared with topoisomerase IV. Typically, it is composed of two copies each of an A subunit (GyrA) and a B subunit (GyrB). got7fsn_ti topoisomerase II complex krc 2019-08-20T18:36:35Z cellular_component owl:Class
GO:0008842 biolink:NamedThing diphosphate-purine nucleoside kinase activity Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide. got7fsn_ti pyrophosphate-dependent nucleoside kinase activity|diphosphate-dependent nucleoside kinase activity|pyrophosphate-purine nucleoside kinase activity|diphosphate:purine nucleoside phosphotransferase activity MetaCyc:2.7.1.143-RXN|EC:2.7.1.143 molecular_function owl:Class
GO:0034270 biolink:NamedThing Cvt complex A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p. got7fsn_ti cytoplasm-to-vacuole targeting complex|cytoplasm to vacuole targeting complex cellular_component owl:Class
GO:0010818 biolink:NamedThing T cell chemotaxis The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex. got7fsn_ti T-cell chemotaxis biological_process owl:Class
GO:0098825 biolink:NamedThing peptidyl-histidine guanylation The guanylylation of peptidyl-histidine to form (phospho-5'-guanosine)-L-histidine. got7fsn_ti RESID:AA0325 biological_process owl:Class
GO:0047066 biolink:NamedThing phospholipid-hydroperoxide glutathione peroxidase activity Catalysis of the reaction: a lipid hydroperoxide + 2 reduced glutathione = 2 H2O + lipid + 2 oxidized glutathione. got7fsn_ti peroxidation-inhibiting protein activity|phospholipid hydroperoxide glutathione peroxidase activity|glutathione:lipid-hydroperoxide oxidoreductase activity|peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing)|PHGPX|hydroperoxide glutathione peroxidase activity MetaCyc:1.11.1.12-RXN|RHEA:19057|Reactome:R-HSA-9018895|EC:1.11.1.12|Reactome:R-HSA-9020271|Reactome:R-HSA-9018868|Reactome:R-HSA-9020273 molecular_function owl:Class
GO:0018489 biolink:NamedThing vanillate monooxygenase activity Catalysis of the reaction: H(+) + NADH + O(2) + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H(2)O + NAD(+). got7fsn_ti vanillate demethylase (aerobic) activity|4-hydroxy-3-methoxybenzoate demethylase activity|vanillate:oxygen oxidoreductase (demethylating)|vanillate demethylase activity Note that this was EC:1.2.3.12. EC:1.14.13.82|MetaCyc:RXN-10891|KEGG_REACTION:R05274|UM-BBD_reactionID:r0146|RHEA:13021|MetaCyc:RXN-2 molecular_function owl:Class
GO:0045961 biolink:NamedThing negative regulation of development, heterochronic Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and decreases the rate at which this time point is reached. got7fsn_ti inhibition of development, heterochronic|down regulation of development, heterochronic|down-regulation of development, heterochronic|downregulation of development, heterochronic biological_process owl:Class
GO:0090193 biolink:NamedThing positive regulation of glomerulus development Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. got7fsn_ti tb 2009-12-18T11:17:13Z biological_process owl:Class
GO:0047332 biolink:NamedThing diphosphate-serine phosphotransferase activity Catalysis of the reaction: L-serine + diphosphate = O-phospho-L-serine + H(+) + phosphate. got7fsn_ti pyrophosphate-L-serine phosphotransferase activity|pyrophosphate--serine phosphotransferase activity|diphosphate:L-serine O-phosphotransferase activity KEGG_REACTION:R00584|MetaCyc:2.7.1.80-RXN|EC:2.7.1.80|RHEA:23764 molecular_function owl:Class
GO:0018678 biolink:NamedThing 4-hydroxybenzoate 1-hydroxylase activity Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2. got7fsn_ti 4-hydroxybenzoate 1-monooxygenase activity|4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating) MetaCyc:1.14.13.64-RXN|UM-BBD_reactionID:r0752|EC:1.14.13.64 molecular_function owl:Class
GO:0106136 biolink:NamedThing lectin-induced modified bacterial internalization The process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti LIMBI hjd 2018-08-09T17:27:18Z biological_process owl:Class
GO:0051696 biolink:NamedThing pointed-end actin filament uncapping The removal of capping protein from the pointed (or minus) end of actin filaments to free the ends for addition, exchange or removal of further actin subunits. got7fsn_ti minus-end actin filament uncapping|pointed-end F-actin uncapping|pointed end F-actin uncapping|minus end F-actin uncapping|minus-end F-actin uncapping|pointed end actin filament uncapping|minus end actin filament uncapping biological_process owl:Class
GO:1990017 biolink:NamedThing somatic portion of tanycyte Portion of a tanycyte that lies within the ependyma and contains the nucleus. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. got7fsn_ti somatic portion pr 2012-12-19T15:19:25Z NIF_Subcellular:sao401910342 cellular_component owl:Class
GO:0070505 biolink:NamedThing pollen coat A layer of extracellular matrix deposited onto the surface of the pollen wall upon disintegration of the tapetal layer of the anther wall in the late stages of pollen development. The composition of this material is highly heterogeneous and includes waxes, lipid droplets, small aromatic molecules, and proteins. The pollen coat is proposed to have many functions, such as holding pollen in the anther until dispersal, facilitation of pollen dispersal, protection of pollen from water loss and UV radiation, and facilitation of adhesion of pollen to the stigma. got7fsn_ti tryphine|pollenkitt cellular_component owl:Class
GO:0044344 biolink:NamedThing cellular response to fibroblast growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus. got7fsn_ti cellular response to FGF stimulus jl 2010-08-25T02:00:51Z biological_process owl:Class
GO:0004809 biolink:NamedThing tRNA (guanine-N2-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. got7fsn_ti transfer ribonucleate guanine N2-methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity|tRNA(guanine-26,N(2)-N(2)) methyltransferase activity|N2,N2-dimethylguanine tRNA methyltransferase activity|N(2),N(2)-dimethylguanine tRNA methyltransferase activity|tRNA(m(2,2)G26)dimethyltransferase activity|tRNA(guanine-26,N2-N2) methyltransferase activity|S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity|tRNA 2,2-dimethylguanosine-26 methyltransferase activity|transfer ribonucleate guanine 2-methyltransferase activity|transfer RNA guanine 2-methyltransferase activity|guanine-N2-methylase activity Reactome:R-HSA-6786501|Reactome:R-HSA-6782416 molecular_function owl:Class
GO:0045098 biolink:NamedThing type III intermediate filament A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments. got7fsn_ti glial fibrillary acidic protein|peripherin|desmin|type III intermediate filament associated protein|vimentin cellular_component owl:Class
GO:0061530 biolink:NamedThing aspartate secretion, neurotransmission The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter. got7fsn_ti dph 2013-06-21T15:50:10Z biological_process owl:Class
GO:0061528 biolink:NamedThing aspartate secretion The regulated release of aspartate by a cell. got7fsn_ti dph 2013-06-21T15:45:37Z biological_process owl:Class
GO:0050215 biolink:NamedThing propanediol dehydratase activity Catalysis of the reaction: propane-1,2-diol = H(2)O + propanal. got7fsn_ti propane-1,2-diol hydro-lyase activity|propanediol dehydrase activity|diol dehydratase activity|diol dehydrase activity|adenosylcobalamin-dependent diol dehydratase activity|1,2-propanediol dehydratase activity|propane-1,2-diol hydro-lyase (propanal-forming)|DL-1,2-propanediol hydro-lyase activity|meso-2,3-butanediol dehydrase activity|dioldehydratase activity|coenzyme B12-dependent diol dehydrase activity RHEA:14569|KEGG_REACTION:R02376|EC:4.2.1.28|MetaCyc:PROPANEDIOL-DEHYDRATASE-RXN molecular_function owl:Class
GO:0052677 biolink:NamedThing D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity Catalysis of the reaction: D-arabinitol + NADP+ = D-xylulose + NADPH + H+. got7fsn_ti NADP+-dependent D-arabinitol dehydrogenase activity|ARD1p|D-arabinitol dehydrogenase 1 activity|D-arabinitol:NADP+ dehydrogenase activity ai 2011-04-12T02:33:43Z RHEA:21276|MetaCyc:RXN-7971|KEGG_REACTION:R07143 molecular_function owl:Class
GO:1990103 biolink:NamedThing DnaA-HU complex A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC. got7fsn_ti DnaA-HU-DNA complex bhm 2013-05-14T12:36:39Z cellular_component owl:Class
GO:0070694 biolink:NamedThing deoxyribonucleoside 5'-monophosphate N-glycosidase activity Catalysis of the reaction: a deoxyribonucleoside 5'-monophosphate + H2O = deoxyribose 5-monophosphate + a purine or pyrimidine base. got7fsn_ti deoxynucleoside 5'-monophosphate N-glycosidase activity mah 2009-06-04T03:06:57Z Reactome:R-HSA-8953339 molecular_function owl:Class
GO:0031718 biolink:NamedThing type 1 cannabinoid receptor binding Binding to a type 1 cannabinoid receptor. got7fsn_ti type 1 cannabinoid receptor ligand molecular_function owl:Class
GO:0034355 biolink:NamedThing NAD salvage Any process that generates nicotinamide adenine dinucleotide (NAD) from derivatives of it, without de novo synthesis; salvage is usually from the degradation products nicotinic acid (Na) and nicotinamide (Nam). got7fsn_ti NAD salvage pathway biological_process owl:Class
GO:0042140 biolink:NamedThing late meiotic recombination nodule assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over. got7fsn_ti biological_process owl:Class
GO:0007146 biolink:NamedThing meiotic recombination nodule assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes. got7fsn_ti biological_process owl:Class
GO:0102500 biolink:NamedThing beta-maltose 4-alpha-glucanotransferase activity Catalysis of the reaction: beta-D-glucose + a plant soluble heteroglycan = a plant soluble heteroglycan + maltose. got7fsn_ti MetaCyc:RXN-14354|EC:2.4.1.25 molecular_function owl:Class
GO:1990971 biolink:NamedThing EMILIN complex Glycoprotein complex of the C1q/TNF superfamily found in the extracellular matrix (ECM) where it is an important component of the elastic fiber system. A homotrimer that will combine to form supramolecular EMILIN structures. got7fsn_ti EMILIN-1 complex|Elastic microfibrillar interface 1 complex|Elastic microfibrillar interface 2 complex|EMILIN-2 complex An example of this is EMILIN-1 in human (Q9Y6C2) in PMID:10821830 (inferred from direct assay). bhm 2016-06-21T14:41:18Z cellular_component owl:Class
GO:0030197 biolink:NamedThing extracellular matrix constituent, lubricant activity Functions as a lubricant for an extracellular matrix, such as a mucous membrane. got7fsn_ti core matrisome|core extracellular matrix Extracellular matrix mucin proteins may be annotated to this term. PMID:14711375, PMID:18601586 molecular_function owl:Class
GO:0031527 biolink:NamedThing filopodium membrane The portion of the plasma membrane surrounding a filopodium. got7fsn_ti cellular_component owl:Class
GO:0071080 biolink:NamedThing alpha3-beta1 integrin-basigin complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the cell surface protein basigin. got7fsn_ti ITGA3-ITGB1-BSG complex mah 2009-11-06T04:43:26Z cellular_component owl:Class
GO:0039662 biolink:NamedThing host cell outer membrane A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell. got7fsn_ti outer membrane of host cell|host cell envelope outer membrane bf 2013-08-25T10:48:41Z cellular_component owl:Class
GO:0031443 biolink:NamedThing fast-twitch skeletal muscle fiber contraction A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability. got7fsn_ti fast-twitch skeletal myofibre contraction|fast-twitch skeletal myofiber contraction|fast-twitch skeletal muscle fibre contraction|fast-twitch skeletal fiber contraction|fast-twitch skeletal fibre contraction biological_process owl:Class
GO:0014721 biolink:NamedThing twitch skeletal muscle contraction A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation. got7fsn_ti biological_process owl:Class
GO:0060424 biolink:NamedThing lung field specification The process that results in the delineation of a specific region of the foregut into the area in which the lung will develop. got7fsn_ti lung specification biological_process owl:Class
GO:0102495 biolink:NamedThing GA5 3beta-hydroxylase activity Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A3 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-14318 molecular_function owl:Class
GO:0019915 biolink:NamedThing lipid storage The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. got7fsn_ti storage of lipids|retention of lipids|lipid retention|sequestration of lipids|sequestration of lipid|sequestering of lipids|lipid sequestering|lipid sequestration biological_process owl:Class
GO:0035494 biolink:NamedThing SNARE complex disassembly The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. got7fsn_ti bf 2010-04-26T02:54:17Z biological_process owl:Class
GO:0060887 biolink:NamedThing limb epidermis development The process whose specific outcome is the progression of the epidermis of the limb over time, from its formation to the mature structure. The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium. got7fsn_ti dph 2009-08-13T12:39:39Z biological_process owl:Class
GO:0052336 biolink:NamedThing modification by host of symbiont cell wall The process in which an organism effects a change in the structure or function of the symbiont cell wall. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti metabolism of symbiont cell wall by organism biological_process owl:Class
GO:0006644 biolink:NamedThing phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. got7fsn_ti phospholipid metabolism biological_process owl:Class
GO:0046193 biolink:NamedThing anaerobic phenol-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen. got7fsn_ti anaerobic phenol-containing compound catabolism|anaerobic phenol-containing compound breakdown|anaerobic phenol-containing compound degradation biological_process owl:Class
GO:1901038 biolink:NamedThing cyanidin 3-O-glucoside metabolic process The chemical reactions and pathways involving cyanidin 3-O-beta-D-glucoside. got7fsn_ti cyanidin 3-O-beta-D-glucoside metabolic process|cyanidin 3-O-beta-D-glucoside metabolism tb 2012-06-22T12:16:26Z biological_process owl:Class
GO:0034544 biolink:NamedThing trans-ACOHDA hydrolase activity Catalysis of the reaction: trans-4-amino-6-carboxy-2-oxo-hexa-3,5-dienoate + H2O = fumarylpyruvate + NH3. got7fsn_ti UM-BBD_reactionID:r0810|EC:3.5.99.- molecular_function owl:Class
GO:0102897 biolink:NamedThing abietadienal hydroxylase activity Catalysis of the reaction: abietal + NADPH + O2 <=> abietate + NADP + H2O. got7fsn_ti RHEA:56928|MetaCyc:RXN-8510 molecular_function owl:Class
GO:0044605 biolink:NamedThing phosphocholine transferase activity Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate. got7fsn_ti jl 2012-05-24T04:44:25Z molecular_function owl:Class
GO:0060276 biolink:NamedThing maintenance of stationary phase in response to toxin The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment. got7fsn_ti biological_process owl:Class
GO:0060274 biolink:NamedThing maintenance of stationary phase The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment. got7fsn_ti biological_process owl:Class
GO:0047579 biolink:NamedThing 4-hydroxymandelate oxidase activity Catalysis of the reaction: (S)-4-hydroxymandelate + H(+) + O(2) = 4-hydroxybenzaldehyde + CO(2) + H(2)O(2). got7fsn_ti (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase activity|L-4-hydroxymandelate oxidase (decarboxylating) MetaCyc:4-HYDROXYMANDELATE-OXIDASE-RXN|RHEA:15833|KEGG_REACTION:R02673|EC:1.1.3.19 molecular_function owl:Class
GO:0018716 biolink:NamedThing 1-phenanthrol glycosyltransferase activity Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O. got7fsn_ti UM-BBD_reactionID:r0525 molecular_function owl:Class
GO:0033873 biolink:NamedThing petromyzonol sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-diphosphate + H(+). got7fsn_ti PZ-SULT|3'-phosphoadenylyl-sulfate:5alpha-cholan-3alpha,7alpha,12alpha,24-tetrol sulfotransferase activity EC:2.8.2.31|MetaCyc:2.8.2.31-RXN|RHEA:16997|KEGG_REACTION:R07797 molecular_function owl:Class
GO:0010357 biolink:NamedThing homogentisate solanesyltransferase activity Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate. got7fsn_ti molecular_function owl:Class
GO:0055041 biolink:NamedThing cyclopentanol dehydrogenase activity Catalysis of the reaction: cyclopentanol + NAD(+) = cyclopentanone + H(+) + NADH. got7fsn_ti cyclopentanol:NADP+ oxidoreductase activity|cyclopentanol:NAD+ oxidoreductase activity MetaCyc:CYCLOPENTANOL-DEHYDROGENASE-RXN|KEGG_REACTION:R02553|EC:1.1.1.163|RHEA:11728 molecular_function owl:Class
GO:0120280 biolink:NamedThing ciliary pro-basal body The cilary pro-basal body is an immature, partially assembled form of a ciliary basal body found next to the basal body of a cilium. Pro-basal bodies are not capable of nucleating a cilium. As the cell progresses through the cell cycle, continuing assembly will convert the pro-basal body into a mature basal body that is capable of nucleating a cilium. got7fsn_ti pro-basal body|pro-centriole|flagellar pro-basal body|probasal body|flagellar probasal body https://github.com/geneontology/go-ontology/issues/14963 Pro-basal bodies are distinct from basal bodies as they are not at the base of a cilium and are not capable of nucleating a cilium. While immature, they contain some structures in common with the mature basal body and also may contain proteins unique to the immature state. Note that cilia and eukaryotic flagella are deemed to be equivalent. In many eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. In other eukaryotic cells, centrioles are not involved in cell division but only in cilium assembly, which is thought to be the ancestral role of the centriole/basal body. krc 2020-10-29T22:54:44Z cellular_component owl:Class
GO:0008740 biolink:NamedThing L-rhamnose isomerase activity Catalysis of the reaction: L-rhamnose = L-rhamnulose. got7fsn_ti L-rhamnose aldose-ketose-isomerase activity|rhamnose isomerase activity|L-rhamnose ketol-isomerase activity EC:5.3.1.14|RHEA:23160|KEGG_REACTION:R02437|MetaCyc:RHAMNISOM-RXN molecular_function owl:Class
GO:0009558 biolink:NamedThing embryo sac cellularization The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana. got7fsn_ti megagametophyte cellularization|female gametophyte cellularization|cellularization of the embryo sac GO:0009797 biological_process owl:Class
GO:0160001 biolink:NamedThing extrasynaptic signaling via GABA Cell-cell signaling that starts with the activation of extrasynaptic GABA receptors in neurons through binding of ambient gamma-aminobutyric acid present in the extracellular fluid. got7fsn_ti rl 2021-02-26T23:08:15Z biological_process owl:Class
GO:0007214 biolink:NamedThing gamma-aminobutyric acid signaling pathway The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor. got7fsn_ti 4-aminobutanoate signaling pathway|4-aminobutyrate signaling pathway|gamma-aminobutyric acid signalling pathway|GABA signalling pathway|4-aminobutanoate signalling pathway|4-aminobutyrate signalling pathway|GABA signaling pathway biological_process owl:Class
GO:0102350 biolink:NamedThing trans-cerot-2-enoyl-CoA reductase activity Catalysis of the reaction: hexacosanoyl-CoA(4-) + NADP(3-) <=> trans-2-hexacosenoyl-CoA + NADPH + H+. got7fsn_ti MetaCyc:RXN-13309 molecular_function owl:Class
GO:0071283 biolink:NamedThing cellular response to iron(III) ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus. got7fsn_ti cellular response to iron(III) mah 2009-12-10T03:58:00Z biological_process owl:Class
GO:0010998 biolink:NamedThing regulation of translational initiation by eIF2 alpha phosphorylation Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha. got7fsn_ti regulation of translational initiation by eIF2 alpha phosphorylation in response to stress|eIF2 alpha phosphorylation in response to stress Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'. tb 2009-06-10T11:27:47Z biological_process owl:Class
GO:0140706 biolink:NamedThing protein-containing complex localization to centriolar satellite A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite. got7fsn_ti https://github.com/geneontology/go-ontology/issues/22020 pg 2021-09-01T05:59:13Z biological_process owl:Class
GO:0097248 biolink:NamedThing maintenance of protein location in cell cortex of cell tip A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell. got7fsn_ti pr 2012-02-20T04:27:31Z biological_process owl:Class
GO:0032065 biolink:NamedThing maintenance of protein location in cell cortex A process in which a protein or protein complex is maintained in a specific location in the cell cortex. got7fsn_ti maintenance of protein location in cell cortex|cortical protein anchoring biological_process owl:Class
GO:0030251 biolink:NamedThing guanylate cyclase inhibitor activity Stops, prevents or reduces the activity of guanylate cyclase. got7fsn_ti molecular_function owl:Class
GO:0051367 biolink:NamedThing peptidyl-serine decanoylation The decanoylation of peptidyl-serine to form peptidyl-O3-decanoyl-L-serine, typical of the protein ghrelin. got7fsn_ti RESID:AA0385 biological_process owl:Class
GO:0000102 biolink:NamedThing L-methionine secondary active transmembrane transporter activity Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti L-methionine porter activity molecular_function owl:Class
GO:0048648 biolink:NamedThing caste determination The process in which individuals, having the potential to develop any of several distinct developmental paths, have their individual developmental fate determined in response to environmental and/or genetic cues. Individuals with distinct developmental fates perform different functions in a colony of social insects. got7fsn_ti biological_process owl:Class
GO:0060684 biolink:NamedThing epithelial-mesenchymal cell signaling Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted. got7fsn_ti epithelial-mesenchymal cell signalling dph 2009-06-03T06:36:46Z biological_process owl:Class
GO:0080162 biolink:NamedThing intracellular auxin transport The directed movement of auxins within a cell. Auxins are a group of plant hormones that regulates aspects of plant growth. got7fsn_ti dhl 2010-09-23T03:46:29Z biological_process owl:Class
GO:0097154 biolink:NamedThing GABAergic neuron differentiation The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron. got7fsn_ti pr 2011-09-14T09:39:11Z biological_process owl:Class
GO:0033255 biolink:NamedThing SAS acetyltransferase complex A protein complex that possesses histone acetyltransferase activity and links histone acetylation to the assembly of transcriptionally silent chromatin. In vitro, the complex acetylates lysine 16 of histone H4 and lysine 14 of histone H3, although the latter may not be relevant in vivo. The complex contains a catalytic subunit and at least two other subunits; in Saccharomyces, the catalytic subunit is Sas2p and additional subunits are Sas4p and Sas5p. got7fsn_ti SAS-I complex cellular_component owl:Class
GO:0044342 biolink:NamedThing type B pancreatic cell proliferation The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. got7fsn_ti pancreatic beta cell proliferation|pancreatic B cell proliferation jl 2010-08-25T01:44:51Z biological_process owl:Class
GO:0050107 biolink:NamedThing monoterpenol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester. got7fsn_ti acetyl-CoA:monoterpenol O-acetyltransferase activity|menthol transacetylase activity MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN|EC:2.3.1.69 molecular_function owl:Class
GO:0034431 biolink:NamedThing bis(5'-adenosyl)-hexaphosphatase activity Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate. got7fsn_ti diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity|AP6A hydrolase activity|AP-6-A hydrolase activity|AP(6)A hydrolase activity RHEA:32047 molecular_function owl:Class
GO:0036105 biolink:NamedThing peroxisome membrane class-1 targeting sequence binding Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner. got7fsn_ti class 1 mPTS binding|PEX19-dependent mPTS binding Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence. bf 2012-01-27T02:02:22Z molecular_function owl:Class
GO:0033328 biolink:NamedThing peroxisome membrane targeting sequence binding Binding to a peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane. got7fsn_ti peroxisomal membrane protein (PMP) targeting signal (mPTS) binding|PMP targeting signal (mPTS) binding|PMP targeting signal binding|mPTS binding molecular_function owl:Class
GO:0047946 biolink:NamedThing glutamine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + L-glutamine = CoA + N-acyl-L-glutamine. got7fsn_ti acyl-CoA:L-glutamine N-acyltransferase activity EC:2.3.1.68|RHEA:18469|MetaCyc:GLUTAMINE-N-ACYLTRANSFERASE-RXN molecular_function owl:Class
GO:0004848 biolink:NamedThing ureidoglycolate hydrolase activity Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+). got7fsn_ti (S)-ureidoglycolate amidohydrolase (decarboxylating) Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN|EC:3.5.3.19|KEGG_REACTION:R00469|RHEA:19809 molecular_function owl:Class
GO:0031771 biolink:NamedThing type 1 hypocretin receptor binding Binding to a type 1 hypocretin receptor. got7fsn_ti type 1 hypocretin receptor ligand|type 1 orexin receptor binding molecular_function owl:Class
GO:0052009 biolink:NamedThing disruption by symbiont of host cell wall A process carried out by a symbiont that breaks down the cell wall of its host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti disassembly by symbiont of host cell wall biological_process owl:Class
GO:0099642 biolink:NamedThing retrograde axonal protein transport The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons. got7fsn_ti retrograde axon cargo transport biological_process owl:Class
GO:0008694 biolink:NamedThing 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2. got7fsn_ti 3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity|UbiX|3-octaprenyl-4-hydroxybenzoate decarboxylase activity|polyprenyl p-hydroxybenzoate decarboxylase activity|UbiD|PPHB decarboxylase activity|3-polyprenyl 4-hydroxybenzoate decarboxylase activity GO:0019167 RHEA:27778|EC:4.1.1.98|MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN molecular_function owl:Class
GO:0060084 biolink:NamedThing synaptic transmission involved in micturition The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body. got7fsn_ti synaptic transmission involved in urination biological_process owl:Class
GO:0072065 biolink:NamedThing long descending thin limb bend development The process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment. got7fsn_ti mah 2010-01-25T04:13:38Z biological_process owl:Class
GO:0050509 biolink:NamedThing N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP. got7fsn_ti UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity|N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity|heparan glucuronyltransferase II activity Reactome:R-HSA-9036285|MetaCyc:2.4.1.225-RXN|Reactome:R-HSA-3656257|Reactome:R-HSA-2076392|Reactome:R-HSA-9036289|Reactome:R-HSA-2022856|Reactome:R-HSA-3656267|RHEA:20908|EC:2.4.1.225 molecular_function owl:Class
GO:0021573 biolink:NamedThing rhombomere 7 development The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0016612 biolink:NamedThing molybdenum-iron nitrogenase complex An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer. got7fsn_ti molybdenum-iron nitrogenase activity cellular_component owl:Class
GO:0060529 biolink:NamedThing squamous basal epithelial stem cell differentiation involved in prostate gland acinus development The process in which a relatively unspecialized epithelial cell acquires specialized features of a squamous basal epithelial stem cell of the prostate. got7fsn_ti biological_process owl:Class
GO:0002067 biolink:NamedThing glandular epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland. got7fsn_ti biological_process owl:Class
GO:1990408 biolink:NamedThing calcitonin gene-related peptide receptor signaling pathway A series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers. got7fsn_ti calcitonin-gene-related peptide receptor signaling pathway|CGRP receptor signaling pathway|calcitonin-gene-related polypeptide receptor signaling pathway An example of a protein that could be annotated to this term is CALCRL in human (Q16602) in PMID:10882736. bhm 2014-07-02T14:32:37Z biological_process owl:Class
GO:0106324 biolink:NamedThing (S)-limonene 1,2-monooxygenase NADH activity Catalysis of the reaction: (4S)-limonene + NADH + H+ + O2 = NAD+ + H2O + (4S)-limonene-1,2-epoxide. got7fsn_ti hjd 2020-09-23T15:35:58Z RHEA:26089 molecular_function owl:Class
GO:0052601 biolink:NamedThing (S)-limonene 1,2-monooxygenase activity Catalysis of the reaction: (4S)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4S)-limonene-1,2-epoxide. got7fsn_ti (S)-limonene,NAD(P)H:oxygen oxidoreductase activity|(-)-limonene 1,2-monooxygenase activity|(-)-limonene,NAD(P)H:oxygen oxidoreductase activity KEGG_REACTION:R09389|KEGG_REACTION:R09385|EC:1.14.13.107|MetaCyc:RXN-9409 molecular_function owl:Class
GO:0035128 biolink:NamedThing post-embryonic forelimb morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism. got7fsn_ti biological_process owl:Class
GO:0045842 biolink:NamedThing positive regulation of mitotic metaphase/anaphase transition Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. got7fsn_ti upregulation of mitotic metaphase/anaphase transition|up regulation of mitotic metaphase/anaphase transition|activation of mitotic metaphase/anaphase transition|stimulation of mitotic metaphase/anaphase transition|up-regulation of mitotic metaphase/anaphase transition biological_process owl:Class
GO:1901970 biolink:NamedThing positive regulation of mitotic sister chromatid separation Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation. got7fsn_ti upregulation of sister chromatid separation during mitosis|upregulation of mitotic sister chromatid separation|up regulation of mitotic sister chromatid resolution|activation of sister chromatid separation during mitosis|positive regulation of chromosome separation during mitosis|upregulation of mitotic sister chromatid resolution|up-regulation of sister chromatid separation during mitosis|positive regulation of sister chromatid separation during mitosis|upregulation of mitotic chromosome separation|up regulation of mitotic chromosome separation|up regulation of sister chromatid separation during mitosis|up regulation of mitotic sister chromatid separation|activation of mitotic chromosome separation|positive regulation of mitotic sister chromatid resolution|up-regulation of mitotic chromosome separation|positive regulation of mitotic chromosome separation|up regulation of chromosome separation during mitosis|activation of chromosome separation during mitosis|upregulation of chromosome separation during mitosis|up-regulation of mitotic sister chromatid separation|up-regulation of chromosome separation during mitosis|activation of mitotic sister chromatid separation|up-regulation of mitotic sister chromatid resolution|activation of mitotic sister chromatid resolution al 2013-02-22T19:06:19Z biological_process owl:Class
GO:0002367 biolink:NamedThing cytokine production involved in immune response The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti cytokine biosynthetic process involved in immune response|cytokine production during immune response|cytokine secretion during immune response|cytokine secretion involved in immune response Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0002375|GO:0002374 biological_process owl:Class
GO:0015314 biolink:NamedThing aminotriazole:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out). got7fsn_ti aminotriazole:hydrogen antiporter activity molecular_function owl:Class
GO:0002234 biolink:NamedThing detection of endoplasmic reticulum overloading The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal. got7fsn_ti detection of ER overloading biological_process owl:Class
GO:0018718 biolink:NamedThing 1,2-dihydroxy-phenanthrene glycosyltransferase activity Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP. got7fsn_ti UM-BBD_reactionID:r0569 molecular_function owl:Class
GO:0036500 biolink:NamedThing ATF6-mediated unfolded protein response A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity. got7fsn_ti ATF6 signaling in response to endoplasmic reticulum stress|activating transcription factor 6 signaling in unfolded protein response|ATF6 signal transduction pathway|ATF6-beta UPR branch|UPR signaling by ATF6 stress sensor|ATF6 branch of UPR|ATF6-alpha UPR branch|endoplasmic reticulum unfolded protein response; ATF6 signaling bf 2015-02-05T13:18:58Z biological_process owl:Class
GO:0050161 biolink:NamedThing succinyl-CoA:oxalate CoA-transferase Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate. got7fsn_ti succinyl-beta-ketoacyl-CoA transferase activity|succinyl-CoA:oxalate CoA-transferase activity|oxalate coenzyme A-transferase activity|oxalate CoA-transferase activity MetaCyc:OXALATE-COA-TRANSFERASE-RXN|KEGG_REACTION:R01559|RHEA:23588|EC:2.8.3.2 molecular_function owl:Class
GO:0015990 biolink:NamedThing electron transport coupled proton transport The transport of protons against an electrochemical gradient, using energy from electron transport. got7fsn_ti biological_process owl:Class
GO:0003301 biolink:NamedThing physiological cardiac muscle hypertrophy The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart. got7fsn_ti dph 2009-10-22T10:38:10Z biological_process owl:Class
GO:0008409 biolink:NamedThing 5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. got7fsn_ti Reactome:R-HSA-5358619|Reactome:R-HSA-5358599 molecular_function owl:Class
GO:0061538 biolink:NamedThing histamine secretion, neurotransmission The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter. got7fsn_ti dph 2013-06-21T16:21:21Z biological_process owl:Class
GO:0090076 biolink:NamedThing relaxation of skeletal muscle A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. got7fsn_ti tb 2009-09-11T11:44:32Z biological_process owl:Class
GO:0006621 biolink:NamedThing protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. got7fsn_ti maintenance of protein location in ER lumen biological_process owl:Class
GO:1990277 biolink:NamedThing parasexual conjugation with cellular fusion A conjugation process that results in the union of cellular and genetic information from compatible mating types, without the formation of zygotes. An example of this process is found in Candida albicans. got7fsn_ti mating pr 2014-01-28T10:30:20Z biological_process owl:Class
GO:0022819 biolink:NamedThing potassium ion uniporter activity Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. got7fsn_ti molecular_function owl:Class
GO:0034573 biolink:NamedThing didemethylisoproturon amidohydrolase activity Catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline. got7fsn_ti UM-BBD_reactionID:r0898 molecular_function owl:Class
GO:0103061 biolink:NamedThing trans-methoxy-C60-meroacyl-AMP ligase activity Catalysis of the reaction: ATP(4-) + H2O + a trans-methoxy-C60-meroacyl-[acp] <=> diphosphoric acid + a trans-methoxy-meroacyl-adenylate + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN1G-4141 molecular_function owl:Class
GO:0050003 biolink:NamedThing deoxycytidylate C-methyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate. got7fsn_ti 5,10-methylenetetrahydrofolate:dCMP C-methyltransferase activity|dCMP methyltransferase activity|deoxycytidylate methyltransferase activity RHEA:11568|EC:2.1.1.54|MetaCyc:DEOXYCYTIDYLATE-C-METHYLTRANSFERASE-RXN|KEGG_REACTION:R01670 molecular_function owl:Class
GO:0003829 biolink:NamedThing beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R. got7fsn_ti uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity|core 2 acetylglucosaminyltransferase activity|O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity|beta(6)-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity|core 6-beta-GlcNAc-transferase A|beta6-N-acetylglucosaminyltransferase activity https://github.com/geneontology/go-ontology/issues/21793 EC:2.4.1.102|Reactome:R-HSA-914012|Reactome:R-HSA-914018|MetaCyc:2.4.1.102-RXN|RHEA:18705 molecular_function owl:Class
GO:0033752 biolink:NamedThing acetylacetone-cleaving enzyme activity Catalysis of the reaction: pentane-2,4-dione + O2 = acetate + 2-oxopropanal. got7fsn_ti acetylacetone-cleaving enzyme|acetylacetone:oxygen oxidoreductase activity|acetylacetone dioxygenase activity|Dke1|diketone cleaving dioxygenase activity|diketone cleaving enzyme EC:1.13.11.50|RHEA:12877 molecular_function owl:Class
GO:0044302 biolink:NamedThing dentate gyrus mossy fiber Distinctive, unmyelinated axons produced by granule cells. got7fsn_ti dentate gyrus mossy fibre|granule cell axon jl 2010-02-05T11:23:55Z NIF_Subcellular:nlx_subcell_20090601 cellular_component owl:Class
GO:0045550 biolink:NamedThing geranylgeranyl reductase activity Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group. got7fsn_ti molecular_function owl:Class
GO:0046402 biolink:NamedThing O antigen metabolic process The chemical reactions and pathways involving the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide. got7fsn_ti O antigen metabolism biological_process owl:Class
GO:0102127 biolink:NamedThing 8-oxoguanine deaminase activity Catalysis of the reaction: H+ + 7,8-dihydro-8-oxoguanine + H2O <=> 7,9-dihydro-1H-purine-2,6,8(3H)-trione + ammonium. got7fsn_ti RHEA:32067|MetaCyc:RXN-11455|EC:3.5.4.32 molecular_function owl:Class
GO:0035790 biolink:NamedThing platelet-derived growth factor receptor-alpha signaling pathway A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti PDGF receptor-alpha signaling pathway|platelet-derived growth factor receptor-alpha signalling pathway|PDGFR-alpha signaling pathway|alphaPDGF receptor signaling pathway bf 2011-04-06T10:55:16Z biological_process owl:Class
GO:0016605 biolink:NamedThing PML body A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. got7fsn_ti nuclear dot|PML nuclear body|PML NB|ND10 cellular_component owl:Class
GO:0030733 biolink:NamedThing fatty acid O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester. got7fsn_ti S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity|fatty-acid O-methyltransferase activity|fatty acid methyltransferase activity MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN|EC:2.1.1.15|RHEA:23012 molecular_function owl:Class
GO:1900598 biolink:NamedThing demethylkotanin catabolic process The chemical reactions and pathways resulting in the breakdown of demethylkotanin. got7fsn_ti demethylkotanin breakdown|demethylkotanin catabolism|demethylkotanin degradation di 2012-05-15T06:55:14Z biological_process owl:Class
GO:0102160 biolink:NamedThing cyanidin-3-O-glucoside 2-O-glucuronosyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-glucuronate <=> H+ + cyanidin 3-O-beta-(2-O-beta-D-glucuronosyl)-beta-D-glucoside + UDP. got7fsn_ti MetaCyc:RXN-11756|EC:2.4.1.254|RHEA:28258 molecular_function owl:Class
GO:0044875 biolink:NamedThing gamma-glutamyl hercynylcysteine sulfoxide synthase activity Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O. got7fsn_ti gamma-glutamyl hercynylcysteine S-oxide synthase|gamma-glutamyl hercynylcysteine sulfoxide synthase https://github.com/geneontology/go-ontology/issues/11163 jl 2014-12-15T11:44:54Z EC:1.14.99.50|RHEA:42672 molecular_function owl:Class
GO:0010454 biolink:NamedThing negative regulation of cell fate commitment Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. got7fsn_ti biological_process owl:Class
GO:0106100 biolink:NamedThing beta-pinacene synthase activity Catalysis of the cyclization of geranylgeranyl pyrophosphate (GGPP) to yield the monocyclic diterpene beta-pinacene. got7fsn_ti hjd 2018-02-15T16:51:59Z molecular_function owl:Class
GO:0035521 biolink:NamedThing monoubiquitinated histone deubiquitination The removal of the ubiquitin group from a monoubiquitinated histone protein. got7fsn_ti monoubiquitinated histone deubiquitinylation|monoubiquitinated histone deubiquitylation bf 2010-05-04T04:32:04Z biological_process owl:Class
GO:0102467 biolink:NamedThing scutellarein 7-O-glucuronosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucuronate + scutellarein <=> UDP( + scutellarin + H+. got7fsn_ti RHEA:28318|EC:2.4.1.253|MetaCyc:RXN-14058 molecular_function owl:Class
GO:0010176 biolink:NamedThing homogentisate phytyltransferase activity Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol. got7fsn_ti MetaCyc:RXN-2541|KEGG_REACTION:R07500|RHEA:37975 molecular_function owl:Class
GO:0018671 biolink:NamedThing 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O. got7fsn_ti 4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)|4-hydroxybenzoate 3-hydroxylase activity|4-hydroxybenzoate-3-hydroxylase activity|4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate)) EC:1.14.13.33|MetaCyc:1.14.13.33-RXN molecular_function owl:Class
GO:0070738 biolink:NamedThing tubulin-glycine ligase activity Catalysis of the posttranslational transfer of one or more glycine residues to a specific glutamate residue on a target tubulin molecule; acts on alpha or beta tubulin. got7fsn_ti tubulin glycylase activity mah 2009-06-19T02:02:01Z molecular_function owl:Class
GO:0042167 biolink:NamedThing heme catabolic process The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. got7fsn_ti haem catabolic process|heme breakdown|heme catabolism|haem catabolism|heme degradation biological_process owl:Class
GO:1990640 biolink:NamedThing inositol-2,4,5-triphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate. got7fsn_ti al 2015-02-11T18:20:40Z molecular_function owl:Class
GO:0004843 biolink:NamedThing thiol-dependent deubiquitinase Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein. got7fsn_ti deubiquitinase|deubiquitinating enzyme|ubiquitin hydrolase activity|UCH2|deubiquitylase|ubiquitinyl hydrolase 1 activity|thiol-dependent ubiquitinyl hydrolase activity|ubiquitinyl hydrolase activity|ubiquitin-specific protease activity|UBP|thiol-dependent ubiquitin-specific protease activity|deubiquitinase activity|ubiquitin C-terminal hydrolase https://github.com/geneontology/go-ontology/issues/19723 GO:0036459 Reactome:R-HSA-5690157|Reactome:R-HSA-5696945|Reactome:R-HSA-5690196|Reactome:R-HSA-870437|Reactome:R-HSA-5689950|EC:3.4.19.12|Reactome:R-HSA-6807206|Reactome:R-HSA-6807118|Reactome:R-HSA-6781764|Reactome:R-HSA-5690152|Reactome:R-HSA-8862184|Reactome:R-HSA-5696872|Reactome:R-HSA-3640872|Reactome:R-HSA-5696968|Reactome:R-HSA-5690159|Reactome:R-HSA-9653514|Reactome:R-HSA-5690790|Reactome:R-HSA-8865182|Reactome:R-HSA-5696605|Reactome:R-HSA-9033491|Reactome:R-HSA-5655466|Reactome:R-HSA-8875443|Reactome:R-HSA-5696914|Reactome:R-HSA-5696564|Reactome:R-HSA-5696465|Reactome:R-HSA-6783177|Reactome:R-HSA-2179291|Reactome:R-HSA-5688797|Reactome:R-HSA-8853514|Reactome:R-HSA-6781779|Reactome:R-HSA-5690759|Reactome:R-HSA-6781814|Reactome:R-HSA-5689972|Reactome:R-HSA-8869456|Reactome:R-HSA-5696600|Reactome:R-HSA-5696958|Reactome:R-HSA-8873946|Reactome:R-HSA-5689973|Reactome:R-HSA-9033478|Reactome:R-HSA-5688837|Reactome:R-HSA-6786171|Reactome:R-HSA-5697009|Reactome:R-HSA-6782628|Reactome:R-HSA-6782820|Reactome:R-HSA-6782106|Reactome:R-HSA-1358795|Reactome:R-HSA-3215310|Reactome:R-HSA-8986083|Reactome:R-HSA-8853515|Reactome:R-HSA-5690319|Reactome:R-HSA-5696947|Reactome:R-HSA-4641236|Reactome:R-HSA-3215295|Reactome:R-HSA-5696534|Reactome:R-HSA-6781897|Reactome:R-HSA-6782069|Reactome:R-HSA-5696627|Reactome:R-HSA-8853529|Reactome:R-HSA-5690080|Reactome:R-HSA-8853503|Reactome:R-HSA-5696960|Reactome:R-HSA-5653770|Reactome:R-HSA-5691381|Reactome:R-HSA-5696997 molecular_function owl:Class
GO:0000088 biolink:NamedThing mitotic prophase The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0046015 biolink:NamedThing regulation of transcription by glucose Any process involving glucose that modulates the frequency, rate or extent or transcription. got7fsn_ti biological_process owl:Class
GO:0002354 biolink:NamedThing central B cell negative selection Any process leading to negative selection of B cells in the bone marrow. got7fsn_ti central B lymphocyte negative selection|central B-lymphocyte negative selection|central B-cell negative selection biological_process owl:Class
GO:0002340 biolink:NamedThing central B cell selection Any B cell selection process that occurs in the bone marrow. got7fsn_ti central B lymphocyte selection|central B-cell selection|central B-lymphocyte selection biological_process owl:Class
GO:0050014 biolink:NamedThing ketotetrose-phosphate aldolase activity Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate. got7fsn_ti erythrulose-1-phosphate formaldehyde-lyase activity|erythrose-1-phosphate synthase activity|phosphoketotetrose aldolase activity|erythrulose-1-phosphate formaldehyde-lyase (glycerone-phosphate-forming)|erythrulose-1-phosphate synthetase activity KEGG_REACTION:R01014|MetaCyc:KETOTETROSE-PHOSPHATE-ALDOLASE-RXN|EC:4.1.2.2|RHEA:20932 molecular_function owl:Class
GO:0016009 biolink:NamedThing minor mitochondrial derivative The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20737 cellular_component owl:Class
GO:1990680 biolink:NamedThing response to melanocyte-stimulating hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates. got7fsn_ti response to MSH sl 2015-03-02T20:49:46Z biological_process owl:Class
GO:0010948 biolink:NamedThing negative regulation of cell cycle process Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. got7fsn_ti tb 2009-04-27T09:53:22Z biological_process owl:Class
GO:0018483 biolink:NamedThing 6-oxohexanoate dehydrogenase activity Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+. got7fsn_ti 6-oxohexanoate:NADP+ oxidoreductase activity MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN|EC:1.2.1.63|RHEA:13397|UM-BBD_reactionID:r0175 molecular_function owl:Class
GO:0051819 biolink:NamedThing induction by symbiont of tumor or growth in host The process in which a symbiont causes the formation of a mass of cells in a host organism. While these growths are often called nodules, they are not formed as nitrogen-fixing structures, but rather to provide an environment for the symbiont to grow. In this sense they are parasitic structures rather than mutualistic. got7fsn_ti induction by symbiont in host of tumor, nodule, or growth containing transformed cells|induction of tumor, nodule, or growth in other organism involved in symbiotic interaction|induction of tumor, nodule, or growth containing transformed cells in other organism involved in symbiotic interaction|induction by symbiont in host of tumor, nodule, or growth|induction by symbiont of nodulation, tumor or growth in host|induction of tumor, nodule, or growth in other organism during symbiotic interaction|induction of tumor, nodule, or growth containing transformed cells in other organism during symbiotic interaction GO:0051820|GO:0044005|GO:0044006 biological_process owl:Class
GO:0002525 biolink:NamedThing acute inflammatory response to non-antigenic stimulus An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma. got7fsn_ti biological_process owl:Class
GO:0006616 biolink:NamedThing SRP-dependent cotranslational protein targeting to membrane, translocation The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen. got7fsn_ti ER translocation|translocation during SRP-dependent cotranslational protein targeting to membrane|SRP-dependent cotranslational membrane targeting, translocation|SRP-dependent cotranslational protein-membrane targeting, translocation biological_process owl:Class
GO:0035232 biolink:NamedThing germ cell attraction The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target. got7fsn_ti biological_process owl:Class
GO:0106077 biolink:NamedThing histone succinylation The modification of a histone by the addition of an succinyl group. got7fsn_ti hjd 2017-12-15T18:27:16Z biological_process owl:Class
GO:0018335 biolink:NamedThing protein succinylation The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue. got7fsn_ti protein amino acid succinylation biological_process owl:Class
GO:0030315 biolink:NamedThing T-tubule Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane. got7fsn_ti transverse tubule|triad Wikipedia:T-tubule cellular_component owl:Class
GO:0033442 biolink:NamedThing AAC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AAC codon. got7fsn_ti asparagine tRNA Note that in the standard genetic code, AAC codes for asparagine. molecular_function owl:Class
GO:0018644 biolink:NamedThing toluene 2-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene. got7fsn_ti UM-BBD_enzymeID:e0222|EC:1.14.13.243|MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN|RHEA:20349 molecular_function owl:Class
GO:0071064 biolink:NamedThing alphaE-beta7 integrin-E-cadherin complex A protein complex that consists of an alphaE-beta7 integrin complex bound to E-cadherin. got7fsn_ti ITGAE-ITGB7-CDH1 complex mah 2009-11-03T04:03:37Z cellular_component owl:Class
GO:0071180 biolink:NamedThing MAML3-RBP-Jkappa-ICN2 complex A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML3-RBP-Jkappa-Notch2 complex mah 2009-11-23T02:51:29Z cellular_component owl:Class
GO:0006056 biolink:NamedThing mannoprotein metabolic process The chemical reactions and pathways involving a mannoprotein, a protein that contains covalently bound mannose residues. got7fsn_ti mannoprotein metabolism biological_process owl:Class
GO:0106272 biolink:NamedThing protein localization to ERGIC A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). got7fsn_ti hjd 2020-07-01T17:04:35Z biological_process owl:Class
GO:0034067 biolink:NamedThing protein localization to Golgi apparatus A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus. got7fsn_ti establishment of protein localization to Golgi apparatus|establishment of protein localisation to Golgi|establishment of protein localization in Golgi|protein targeting to Golgi|protein-Golgi targeting|establishment of protein localization to Golgi|protein localisation in Golgi apparatus|protein localization in Golgi apparatus mah 2011-02-14T02:26:36Z GO:0000042|GO:0072600 biological_process owl:Class
GO:0032789 biolink:NamedThing unsaturated monocarboxylic acid metabolic process The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds. got7fsn_ti unsaturated monocarboxylate metabolic process|unsaturated monocarboxylic acid metabolism biological_process owl:Class
GO:0045111 biolink:NamedThing intermediate filament cytoskeleton Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell. got7fsn_ti cellular_component owl:Class
GO:0071702 biolink:NamedThing organic substance transport The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. got7fsn_ti mah 2010-03-08T02:15:14Z biological_process owl:Class
GO:0099139 biolink:NamedThing cheating during chimeric sorocarp development Any process during chimeric sorocarp development that increases by which a cell increases the number of spore cells sharing its genotype at the expense of cells of other genotypes. got7fsn_ti biological_process owl:Class
GO:0016273 biolink:NamedThing arginine N-methyltransferase activity Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue. got7fsn_ti molecular_function owl:Class
GO:0001732 biolink:NamedThing formation of cytoplasmic translation initiation complex Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site. got7fsn_ti formation of translation initiation complex|cytoplasmic translation initiation complex assembly|translation initiation complex assembly biological_process owl:Class
GO:1990441 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. got7fsn_ti negative regulation of transcription from RNA polymerase II promoter in response to ER stress|ER stress-induced negative regulation of transcription from RNA polymerase II promoter|reduction of transcription from RNA polymerase II promoter under ER stress|inhibition of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|down regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|down-regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|repression of transcription from RNA polymerase II promoter under ER stress|suppression of transcription from RNA polymerase II promoter under ER stress bf 2014-07-31T13:08:54Z biological_process owl:Class
GO:0102711 biolink:NamedThing gibberellin A25,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A25 + 2-oxoglutarate + O2 <=> gibberellin A13 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-6541 molecular_function owl:Class
GO:0036173 biolink:NamedThing thiosulfate binding Binding to a thiosulfate, a sulfur oxide that has formula O3S2. got7fsn_ti bf 2012-03-29T10:38:15Z molecular_function owl:Class
GO:0043168 biolink:NamedThing anion binding Binding to an anion, a charged atom or group of atoms with a net negative charge. got7fsn_ti molecular_function owl:Class
GO:0060253 biolink:NamedThing negative regulation of glial cell proliferation Any process that stops or decreases the rate or extent of glial cell proliferation. got7fsn_ti biological_process owl:Class
GO:0007234 biolink:NamedThing osmosensory signaling via phosphorelay pathway A series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system. got7fsn_ti signal transduction during osmotic stress via two-component system|osmolarity signalling pathway via two-component system|osmosensory signaling pathway via two-component system|osmolarity signaling pathway via two-component system|osmosensory signalling pathway via two-component system|osmolarity sensing via two-component system biological_process owl:Class
GO:0044556 biolink:NamedThing envenomation resulting in negative regulation of heart rate of other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism. got7fsn_ti jl 2012-03-29T03:04:52Z biological_process owl:Class
GO:0046409 biolink:NamedThing p-coumarate 3-hydroxylase activity Catalysis of the reaction: shikimate or quinate ester of p-coumaric acid + NADPH + H+ + O2 = caffeic acid conjugate (caffeoyl shikimic acid or chlorogenic acid) + H2O + NADP+. got7fsn_ti cytochrome P450 CYP98A3 molecular_function owl:Class
GO:0004653 biolink:NamedThing polypeptide N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. got7fsn_ti UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity|UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity|UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity|polypeptide-N-acetylgalactosamine transferase activity|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity|protein-UDP acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity|UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity|glycoprotein acetylgalactosaminyltransferase activity|UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity Reactome:R-HSA-8851619|EC:2.4.1.41|Reactome:R-HSA-913675|MetaCyc:2.4.1.41-RXN|Reactome:R-HSA-5096532|Reactome:R-HSA-9694438|Reactome:R-HSA-5096537|Reactome:R-HSA-9683760 molecular_function owl:Class
GO:0050631 biolink:NamedThing corydaline synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP(+). got7fsn_ti S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase activity RHEA:14773|MetaCyc:2.1.1.147-RXN|EC:2.1.1.147|KEGG_REACTION:R07241 molecular_function owl:Class
GO:0001405 biolink:NamedThing PAM complex, Tim23 associated import motor Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix. got7fsn_ti presequence translocase-associated import motor|pre-sequence translocase-associated import motor|PAM complex|mitochondrial import motor cellular_component owl:Class
GO:0030626 biolink:NamedThing U12 snRNA binding Binding to a U12 small nuclear RNA (U12 snRNA). got7fsn_ti molecular_function owl:Class
GO:0036335 biolink:NamedThing intestinal stem cell homeostasis Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells. got7fsn_ti bf 2012-09-05T10:23:41Z biological_process owl:Class
GO:0043056 biolink:NamedThing forward locomotion Anterior movement of an organism, following the direction of the head of the animal. got7fsn_ti biological_process owl:Class
GO:0019044 biolink:NamedThing maintenance of viral latency The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms. got7fsn_ti prophage maintenance|latent virus maintenance|provirus maintenance GO:0075716|GO:0032360 biological_process owl:Class
GO:0033772 biolink:NamedThing flavonoid 3',5'-hydroxylase activity Catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O. got7fsn_ti F3'5'H|F3',5'H|flavanone,NADPH:oxygen oxidoreductase activity MetaCyc:RXN-7783|MetaCyc:RXN-8671|RHEA:55448|EC:1.14.14.81 molecular_function owl:Class
GO:0044844 biolink:NamedThing meiotic interphase II The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). jl 2014-03-26T16:52:27Z biological_process owl:Class
GO:0005176 biolink:NamedThing ErbB-2 class receptor binding Binding to a protein-tyrosine kinase receptor Neu/ErbB-2/HER2. got7fsn_ti HER2 receptor binding|HER2 receptor ligand|ErbB-2 class receptor ligand|Neu receptor ligand|Neu receptor binding molecular_function owl:Class
GO:0009389 biolink:NamedThing dimethyl sulfoxide reductase activity Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O. got7fsn_ti dimethyl sulphoxide reductase activity UM-BBD_reactionID:r0207|EC:1.8.99.- molecular_function owl:Class
GO:0034953 biolink:NamedThing perillyl-CoA hydratase activity Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA. got7fsn_ti UM-BBD_reactionID:r1002 molecular_function owl:Class
GO:0070652 biolink:NamedThing HAUS complex A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex. got7fsn_ti HAUS augmin complex mah 2009-05-28T03:21:01Z cellular_component owl:Class
GO:0021669 biolink:NamedThing rhombomere 6 formation The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0015420 biolink:NamedThing ABC-type vitamin B12 transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin. got7fsn_ti cobalamin-transporting ATPase activity|cobalamin porter activity|ATP-dependent vitamin B12 transmembrane transporter activity|cobalamin transporter activity|ATP-dependent cobalamin transmembrane transporter activity|vitamin B12 ABC transporter activity|vitamin B12-transporting ATPase activity|cobalamin ABC transporter|vitamin B12 porter activity|ATPase-coupled vitamin B12 transmembrane transporter activity|vitamin B12 transporter activity|ATPase-coupled cobalamin transmembrane transporter activity https://github.com/geneontology/go-ontology/issues/21353 GO:0015235|GO:0102023 EC:7.6.2.8|RHEA:17873|MetaCyc:3.6.3.33-RXN|Reactome:R-HSA-3095901|Reactome:R-HSA-3315437|MetaCyc:ABC-5-RXN|Reactome:R-HSA-3000238 molecular_function owl:Class
GO:0044807 biolink:NamedThing macrophage migration inhibitory factor production The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti MIF production jl 2013-09-11T12:04:09Z biological_process owl:Class
GO:0004252 biolink:NamedThing serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). got7fsn_ti blood coagulation factor activity|serine elastase activity Reactome:R-HSA-3788061|Reactome:R-HSA-1655842|Reactome:R-HSA-186785|Reactome:R-HSA-1602484|Reactome:R-HSA-9023196|Reactome:R-HSA-159733|Reactome:R-HSA-158333|EC:3.4.21.34|Reactome:R-HSA-140870|EC:3.4.21.61|Reactome:R-HSA-166792|Reactome:R-HSA-9668365|Reactome:R-HSA-173745|Reactome:R-HSA-1592278|Reactome:R-HSA-976743|Reactome:R-HSA-140777|Reactome:R-HSA-1604752|Reactome:R-HSA-1602473|Reactome:R-HSA-1181152|EC:3.4.21.71|EC:3.4.24.3|EC:3.4.21.36|Reactome:R-HSA-158766|EC:3.4.21.53|EC:3.4.21.54|Reactome:R-HSA-1602466|Reactome:R-HSA-5691512|Reactome:R-HSA-1592362|EC:3.4.21.26|EC:3.4.21.62|EC:3.4.21.89|Reactome:R-HSA-158313|Reactome:R-HSA-9694287|Reactome:R-HSA-1474197|Reactome:R-HSA-9033506|Reactome:R-HSA-140823|Reactome:R-HSA-2534260|EC:3.4.21.69|Reactome:R-HSA-9023178|EC:3.4.21.-|Reactome:R-HSA-2168960|Reactome:R-HSA-2514772|Reactome:R-HSA-1566962|Reactome:R-HSA-158925|Reactome:R-HSA-1604359|Reactome:R-HSA-174551|EC:3.4.21.9|EC:3.4.21.20|Reactome:R-HSA-114697|Reactome:R-HSA-9666383|EC:3.4.21.92|EC:3.4.21.5|Reactome:R-HSA-173680|Reactome:R-HSA-9033524|Reactome:R-HSA-8874186|Reactome:R-HSA-381466|Reactome:R-HSA-163798|Reactome:R-HSA-9023626|Reactome:R-HSA-6807224|EC:3.4.21.75|Reactome:R-HSA-1912372|EC:3.4.21.10|Reactome:R-HSA-1604763|Reactome:R-HSA-9033520|Reactome:R-HSA-140599|Reactome:R-HSA-1592316|Reactome:R-HSA-8874205|Reactome:R-HSA-9694661|Reactome:R-HSA-1604690|EC:3.4.21.87|Reactome:R-HSA-141026|Reactome:R-HSA-140840|Reactome:R-HSA-8874206|Reactome:R-HSA-6800299|Reactome:R-HSA-159773|Reactome:R-HSA-400496|Reactome:R-HSA-2214330|Reactome:R-HSA-9686710|Reactome:R-HSA-6800198|Reactome:R-HSA-158747|Reactome:R-HSA-9033515|Reactome:R-HSA-1592371|Reactome:R-HSA-422021|Reactome:R-HSA-158300|Reactome:R-HSA-2482180|Reactome:R-HSA-381446|Reactome:R-HSA-3928657|Reactome:R-HSA-1604741|EC:3.4.21.59|Reactome:R-HSA-8865276|Reactome:R-HSA-5210935|EC:3.4.21.73|Reactome:R-HSA-9033530|EC:3.4.21.46|EC:3.4.21.4|Reactome:R-HSA-2172405|Reactome:R-HSA-8849857|Reactome:R-HSA-1454843|Reactome:R-HSA-1592297|Reactome:R-HSA-159868|Reactome:R-HSA-1592436|Reactome:R-HSA-1912369|Reactome:R-HSA-158137|Reactome:R-HSA-1604360|EC:3.4.21.6|Reactome:R-HSA-422051|Reactome:R-HSA-8850831|Reactome:R-HSA-2022411|Reactome:R-HSA-183130|Reactome:R-HSA-5607002|Reactome:R-HSA-158164|Reactome:R-HSA-9686731|EC:3.4.21.27|EC:3.4.21.45|EC:3.4.21.47|MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN|EC:3.4.21.48|Reactome:R-HSA-8852716|Reactome:R-HSA-140696|Reactome:R-HSA-977371|Reactome:R-HSA-2534206|Reactome:R-HSA-171288|Reactome:R-HSA-381798|Reactome:R-HSA-1604732|EC:3.4.21.68|Reactome:R-HSA-159771|EC:3.4.21.7|EC:3.4.21.21|Reactome:R-HSA-3785684|Reactome:R-HSA-9023627|Reactome:R-HSA-2534160|Reactome:R-HSA-158744|Reactome:R-HSA-6801687|EC:3.4.24.7|Reactome:R-HSA-158311|Reactome:R-HSA-3266557|Reactome:R-HSA-141040|Reactome:R-HSA-265301|EC:3.4.21.43|Reactome:R-HSA-8855825|Reactome:R-HSA-1602458|Reactome:R-HSA-9699007|Reactome:R-HSA-381135|Reactome:R-HSA-166753|Reactome:R-HSA-382061|EC:3.4.21.41|Reactome:R-HSA-9670874|Reactome:R-HSA-9653249|Reactome:R-HSA-170844|EC:3.4.21.22|Reactome:R-HSA-9033490|Reactome:R-HSA-9023632|Reactome:R-HSA-173626|Reactome:R-HSA-139893|Reactome:R-HSA-5578783|Reactome:R-HSA-6800200|Reactome:R-HSA-9655046|EC:3.4.21.93|Reactome:R-HSA-140769|Reactome:R-HSA-1604368|Reactome:R-HSA-158942|Reactome:R-HSA-140736|EC:3.4.21.42|Reactome:R-HSA-8865275|Reactome:R-HSA-166817|Reactome:R-HSA-2471621|Reactome:R-HSA-9668253|Reactome:R-HSA-381500|Reactome:R-HSA-3814820|Reactome:R-HSA-1592398|EC:3.4.24.34|EC:3.4.21.39|Reactome:R-HSA-1566979|EC:3.4.19.1|Reactome:R-HSA-9023633|EC:3.4.21.79|EC:3.4.21.94|Reactome:R-HSA-8849826|Reactome:R-HSA-9673223|Reactome:R-HSA-140700|Reactome:R-HSA-2168923|Reactome:R-HSA-8874212|Reactome:R-HSA-1592270|Reactome:R-HSA-400459|Reactome:R-HSA-159728|Reactome:R-HSA-163843|Reactome:R-HSA-187020|Reactome:R-HSA-159796|Reactome:R-HSA-1602488|Reactome:R-HSA-1604731|Reactome:R-HSA-977615|EC:3.4.21.35|Reactome:R-HSA-2514823|Reactome:R-HSA-1604712|Reactome:R-HSA-2129357|EC:3.4.21.102|Reactome:R-HSA-5591040|Reactome:R-HSA-400492|Reactome:R-HSA-158750|Reactome:R-HSA-9662786|Reactome:R-HSA-140664|Reactome:R-HSA-1604722|Reactome:R-HSA-8874204|Reactome:R-HSA-5210912|EC:3.4.21.83|Reactome:R-HSA-158419|EC:3.4.21.38|Reactome:R-HSA-1566981|EC:3.4.21.1|Reactome:R-HSA-9033529|EC:3.4.21.78|Reactome:R-HSA-173631|Reactome:R-HSA-2471842|Reactome:R-HSA-158982|Reactome:R-HSA-1592314|Reactome:R-HSA-183122|EC:3.4.21.88|Reactome:R-HSA-381461|Reactome:R-HSA-1799329 molecular_function owl:Class
GO:0051840 biolink:NamedThing negative regulation by host of cytolysis of symbiont cells Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti down regulation by host of cytolysis of symbiont cells|downregulation by host of cytolysis of symbiont cells|inhibition by host of cytolysis of symbiont cells|down-regulation by host of cytolysis of symbiont cells biological_process owl:Class
GO:0051803 biolink:NamedThing negative regulation of cytolysis in other organism involved in symbiotic interaction Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti down regulation of cytolysis of cells in other organism during symbiotic interaction|inhibition of cytolysis of cells in other organism during symbiotic interaction|downregulation of cytolysis of cells in other organism during symbiotic interaction|negative regulation of cytolysis of cells in other organism during symbiotic interaction|down-regulation of cytolysis of cells in other organism during symbiotic interaction|negative regulation of cytolysis of cells in other organism involved in symbiotic interaction biological_process owl:Class
GO:0140232 biolink:NamedThing intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential. got7fsn_ti intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential https://github.com/geneontology/synapse/issues/231 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-09T11:30:40Z molecular_function owl:Class
GO:0005222 biolink:NamedThing intracellular cAMP-activated cation channel activity Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. got7fsn_ti intracellular adenosine 3',5'-cyclophosphate activated cation channel activity|intracellular 3',5' cAMP activated cation channel activity|intracellular 3',5'-cAMP activated cation channel activity|intracellular cAMP activated cation channel activity|hyperpolarization-activated cyclic nucleotide-gated channel activity|intracellular cyclic AMP activated cation channel activity|HCN channel activity molecular_function owl:Class
GO:0090550 biolink:NamedThing response to molybdenum starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum. got7fsn_ti tb 2013-04-22T13:57:16Z biological_process owl:Class
GO:0036191 biolink:NamedThing indolin-2-one monooxygenase activity Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O. got7fsn_ti indolin-2-one,NAD(P)H:oxygen oxidoreductase (3-hydroxylating) bf 2012-04-19T11:38:01Z RHEA:31919|EC:1.14.14.157|KEGG_REACTION:R07421 molecular_function owl:Class
GO:0032202 biolink:NamedThing telomere assembly A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins. got7fsn_ti telomere formation biological_process owl:Class
GO:0051923 biolink:NamedThing sulfation The addition of a sulfate group to a molecule. got7fsn_ti sulfonation|phase II metabolism|sulphur addition|sulfur addition|sulphation biological_process owl:Class
GO:0048017 biolink:NamedThing inositol lipid-mediated signaling A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. got7fsn_ti inositol phospholipid-mediated signaling|inositol lipid-mediated signal transduction|inositol lipid-mediated signalling biological_process owl:Class
GO:0099126 biolink:NamedThing transforming growth factor beta complex A protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerisation and dissociation of the LAP. got7fsn_ti TGF-beta complex|TGFbeta complex|TGF-beta dimer|TGFB dimer|TGFbeta dimer|TGFB complex cellular_component owl:Class
GO:0018712 biolink:NamedThing 3-hydroxybutyryl-CoA thiolase activity Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA. got7fsn_ti UM-BBD_reactionID:r0010|MetaCyc:R7-RXN molecular_function owl:Class
GO:0020027 biolink:NamedThing hemoglobin metabolic process The chemical reactions and pathways involving hemoglobin, including its uptake and utilization. got7fsn_ti hemoglobin metabolism|haemoglobin metabolic process|haemoglobin metabolism biological_process owl:Class
GO:0110001 biolink:NamedThing toxin-antitoxin complex A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon. got7fsn_ti An example is YoeB (P69348) in Escherichia coli in PMID:16109374 (inferred by direct evidence). kmv cellular_component owl:Class
GO:0102369 biolink:NamedThing 11alpha-30-dihydroxy beta-amyrin dehydrogenase activity Catalysis of the reaction: 11alpha,30-dihydroxy-beta-amyrin + NADPH + O2 + H+ <=> 30-hydroxy-11-oxo-beta-amyrin + NADP + 2 H2O. got7fsn_ti MetaCyc:RXN-13491 molecular_function owl:Class
GO:0010245 biolink:NamedThing radial microtubular system formation Formation of radial microtubular systems during male meiotic cytokinesis in plants. got7fsn_ti biological_process owl:Class
GO:0071040 biolink:NamedThing nuclear polyadenylation-dependent antisense transcript catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an antisense transcript, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target antisense transcript. got7fsn_ti nuclear poly(A)-dependent antisense transcript catabolic process krc 2009-07-29T01:25:21Z biological_process owl:Class
GO:0050818 biolink:NamedThing regulation of coagulation Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass. got7fsn_ti regulation of clotting biological_process owl:Class
GO:0035115 biolink:NamedThing embryonic forelimb morphogenesis The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human. got7fsn_ti embryonic arm morphogenesis GO:0035117 biological_process owl:Class
GO:0035714 biolink:NamedThing cellular response to nitrogen dioxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus. got7fsn_ti cellular response to NO2 bf 2011-03-02T03:16:37Z biological_process owl:Class
GO:0045436 biolink:NamedThing lycopene beta cyclase activity Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively. got7fsn_ti lycopene cyclase|crtL RHEA:32219|MetaCyc:RXN1F-150 molecular_function owl:Class
GO:0052781 biolink:NamedThing chitobiose catabolic process The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine. got7fsn_ti ai 2011-10-03T08:54:17Z biological_process owl:Class
GO:0052782 biolink:NamedThing amino disaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions. got7fsn_ti ai 2011-10-03T08:56:04Z biological_process owl:Class
GO:0014863 biolink:NamedThing detection of inactivity The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0098826 biolink:NamedThing endoplasmic reticulum tubular network membrane The membrane of the endoplasmic reticulum tubular network. got7fsn_ti cellular_component owl:Class
GO:0022872 biolink:NamedThing protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti mannitol PTS transporter activity molecular_function owl:Class
GO:0015575 biolink:NamedThing mannitol transmembrane transporter activity Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. got7fsn_ti mannitol permease activity GO:0015586 molecular_function owl:Class
GO:0000406 biolink:NamedThing double-strand/single-strand DNA junction binding Binding to a DNA segment that contains double-stranded DNA flanked by a region of single-stranded DNA. got7fsn_ti molecular_function owl:Class
GO:0050400 biolink:NamedThing xylitol kinase activity Catalysis of the reaction: ATP + xylitol = ADP + 2 H(+) + xylitol 5-phosphate. got7fsn_ti ATP:xylitol 5-phosphotransferase activity|xylitol phosphotransferase activity RHEA:20209|EC:2.7.1.122|KEGG_REACTION:R02136|MetaCyc:XYLITOL-KINASE-RXN molecular_function owl:Class
GO:0102786 biolink:NamedThing stearoyl-[acp] desaturase activity Catalysis of the reaction: O2 + a stearoyl-[acp] + a reduced ferredoxin = 2 H2O + an oleoyl-[acp] + an oxidized ferredoxin. got7fsn_ti EC:1.14.19.2|MetaCyc:RXN-7903|RHEA:11776 molecular_function owl:Class
GO:2001308 biolink:NamedThing gliotoxin metabolic process The chemical reactions and pathways involving the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. got7fsn_ti gliotoxin metabolism pr 2012-03-15T03:42:10Z biological_process owl:Class
GO:0097139 biolink:NamedThing BID-BCL-2 complex A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:40:31Z cellular_component owl:Class
GO:0003145 biolink:NamedThing embryonic heart tube formation via epithelial folding The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis. got7fsn_ti tb 2009-09-22T04:26:03Z biological_process owl:Class
GO:0002504 biolink:NamedThing antigen processing and presentation of peptide or polysaccharide antigen via MHC class II The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex. got7fsn_ti peptide or polysaccharide antigen processing and presentation of via MHC class II biological_process owl:Class
GO:0033604 biolink:NamedThing negative regulation of catecholamine secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine. got7fsn_ti downregulation of catecholamine secretion|down regulation of catecholamine secretion|down-regulation of catecholamine secretion|inhibition of catecholamine secretion biological_process owl:Class
GO:0003962 biolink:NamedThing cystathionine gamma-synthase activity Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate. got7fsn_ti homoserine O-transsuccinylase activity|O-succinyl-L-homoserine (thiol)-lyase activity|O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity|O-succinylhomoserine synthase activity|cystathionine g-synthase activity|CTT gamma synthase activity|O-succinylhomoserine synthetase activity|cystathionine synthase activity|O-succinylhomoserine (thiol)-lyase activity|cystathionine synthetase activity|O-succinyl-L-homoserine succinate-lyase activity|O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity|cystathionine gamma synthase activity|homoserine transsuccinylase activity GO:0000505 EC:2.5.1.48|MetaCyc:O-SUCCHOMOSERLYASE-RXN|RHEA:20397 molecular_function owl:Class
GO:0033016 biolink:NamedThing rhoptry membrane The lipid bilayer surrounding a rhoptry. got7fsn_ti cellular_component owl:Class
GO:0047844 biolink:NamedThing deoxycytidine deaminase activity Catalysis of the reaction: deoxycytidine + H2O = deoxyuridine + NH3. got7fsn_ti deoxycytidine aminohydrolase activity EC:3.5.4.14|MetaCyc:CYTIDEAM-RXN|RHEA:13433 molecular_function owl:Class
GO:0045454 biolink:NamedThing cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. got7fsn_ti regulation of redox homeostasis|regulation of cell redox homeostasis GO:0045867|GO:0045868|GO:0030503 Wikipedia:Redox biological_process owl:Class
GO:0010112 biolink:NamedThing regulation of systemic acquired resistance Any process that modulates the frequency, rate or extent of systemic acquired resistance. got7fsn_ti biological_process owl:Class
GO:0047910 biolink:NamedThing galactose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: D-galactose + NADP+ = D-galactonolactone + NADPH. got7fsn_ti D-galactose:NADP+ 1-oxidoreductase activity|D-galactose dehydrogenase (NADP+) MetaCyc:GALACTOSE-1-DEHYDROGENASE-NADP+-RXN|EC:1.1.1.120|RHEA:18625 molecular_function owl:Class
GO:0050374 biolink:NamedThing UDP-galacturonate decarboxylase activity Catalysis of the reaction: H(+) + UDP-alpha-D-galacturonate = CO(2) + UDP-L-arabinose. got7fsn_ti UDPGalUA carboxy lyase activity|UDP-D-galacturonate carboxy-lyase (UDP-L-arabinose-forming)|UDP-galacturonic acid decarboxylase activity|UDP-D-galacturonate carboxy-lyase activity|UDPgalacturonate decarboxylase activity MetaCyc:UDP-GALACTURONATE-DECARBOXYLASE-RXN|EC:4.1.1.67|RHEA:19725|KEGG_REACTION:R02636 molecular_function owl:Class
GO:0060152 biolink:NamedThing microtubule-based peroxisome localization The microtubule-based process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. got7fsn_ti microtubule-based peroxisome localisation biological_process owl:Class
BFO:0000040 biolink:NamedThing got7fsn_ti owl:Class
GO:0033959 biolink:NamedThing deoxyribodipyrimidine endonucleosidase activity Catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue. got7fsn_ti PD-DNA glycosylase activity|deoxyribonucleate pyrimidine dimer glycosidase activity|pyrimidine dimer DNA glycosylase activity|endonuclease V activity|deoxy-D-ribocyclobutadipyrimidine polynucleotidodeoxyribohydrolase activity|pyrimidine dimer DNA-glycosylase activity|T4-induced UV endonuclease activity EC:3.2.2.17|MetaCyc:3.2.2.17-RXN molecular_function owl:Class
GO:0110019 biolink:NamedThing IRES-dependent translational initiation of circular RNA The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate circular mRNA translation. got7fsn_ti IRES-dependent translational initiation of circRNA kmv 2017-06-08T15:36:38Z biological_process owl:Class
GO:0018304 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide RESID:AA0286 biological_process owl:Class
GO:0043332 biolink:NamedThing mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth. got7fsn_ti conjugation tube tip|shmoo tip cellular_component owl:Class
GO:0018472 biolink:NamedThing 1-hydroxy-2-naphthaldehyde dehydrogenase activity Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate. got7fsn_ti UM-BBD_reactionID:r0485 molecular_function owl:Class
GO:0035241 biolink:NamedThing protein-arginine omega-N monomethyltransferase activity Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine. got7fsn_ti S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega-methyl-L-arginine-forming)|type III protein arginine methyltransferase activity Type III protein arginine methyltransferases catalyze the single methylation of one of the terminal nitrogen atoms of the guanidino group in an L-arginine residue within a protein. Unlike type I and type II protein arginine methyltransferases, which also catalyze this reaction, type III enzymes do not methylate the substrate any further. RESID:AA0069|RHEA:48100|EC:2.1.1.321 molecular_function owl:Class
GO:0018007 biolink:NamedThing N-terminal peptidyl-glycine N-glucuronylation The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine. got7fsn_ti RESID:AA0058 biological_process owl:Class
GO:0047780 biolink:NamedThing citrate dehydratase activity Catalysis of the reaction: citrate = cis-aconitate + H2O. got7fsn_ti aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|citrate hydro-lyase (cis-aconitate-forming)|citrate hydro-lyase activity This term is also a sub-reaction of 'aconitate hydratase activity ; GO:0003994 (EC:4.2.1.3)'. GO:0052632 MetaCyc:ACONITATEDEHYDR-RXN|RHEA:10228|KEGG_REACTION:R01325|EC:4.2.1.3|MetaCyc:CITRATE-DEHYDRATASE-RXN molecular_function owl:Class
GO:0050224 biolink:NamedThing prunasin beta-glucosidase activity Catalysis of the reaction: (R)-prunasin + H(2)O = D-glucose + mandelonitrile. got7fsn_ti prunasin beta-D-glucohydrolase activity|prunasin hydrolase activity|prunasin b-glucosidase activity MetaCyc:PRUNASIN-BETA-GLUCOSIDASE-RXN|EC:3.2.1.118|KEGG_REACTION:R02558|RHEA:16489 molecular_function owl:Class
GO:0014818 biolink:NamedThing skeletal muscle satellite cell fate determination The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0003427 biolink:NamedThing regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell. got7fsn_ti regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway dph 2009-12-22T11:43:29Z biological_process owl:Class
GO:0099575 biolink:NamedThing regulation of protein catabolic process at presynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0098913 biolink:NamedThing membrane depolarization during ventricular cardiac muscle cell action potential The process in which ventricular cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. got7fsn_ti ventricular depolarization|electrocardiogram QRS complex biological_process owl:Class
GO:0052616 biolink:NamedThing ent-kaur-16-en-19-ol oxidase activity Catalysis of the reaction: H+ + NADPH + ent-kaur-16-en-19-ol + oxygen = 2 H2O + NADP+ + ent-kaur-16-en-19-al. got7fsn_ti RHEA:21304|MetaCyc:RXN-5242|EC:1.14.14.86 molecular_function owl:Class
GO:0120269 biolink:NamedThing ciliary centrin arm A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20062 Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. krc 2020-09-30T18:20:22Z cellular_component owl:Class
GO:0050502 biolink:NamedThing cis-zeatin O-beta-D-glucosyltransferase activity Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H(+) + UDP. got7fsn_ti UDPglucose:cis-zeatin O-beta-D-glucosyltransferase activity|cis-zeatin O-b-D-glucosyltransferase activity|UDP-glucose:cis-zeatin O-beta-D-glucosyltransferase activity MetaCyc:RXN-4735|KEGG_REACTION:R07260|EC:2.4.1.215|RHEA:20681 molecular_function owl:Class
GO:0021847 biolink:NamedThing ventricular zone neuroblast division The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially. got7fsn_ti neuroblast division in ventricular zone biological_process owl:Class
GO:0018216 biolink:NamedThing peptidyl-arginine methylation The addition of a methyl group to an arginine residue in a protein. got7fsn_ti GO:0018017 biological_process owl:Class
GO:0043883 biolink:NamedThing malolactic enzyme activity Catalysis of the reaction: malate + H+ = L-lactate + CO2. got7fsn_ti MleS This function is part of the process of degradation of L-malic acid by lactic acid bacteria. molecular_function owl:Class
GO:0055005 biolink:NamedThing ventricular cardiac myofibril assembly The process whose specific outcome is the progression of the ventricular cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. got7fsn_ti ventricular heart myofibril development|ventricular cardiac myofibril development biological_process owl:Class
GO:0043587 biolink:NamedThing tongue morphogenesis The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech. got7fsn_ti lingua morphogenesis|glossa morphogenesis biological_process owl:Class
GO:0097585 biolink:NamedThing dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p. got7fsn_ti Pmt5p-Pmt3p complex pr 2014-03-02T18:18:28Z cellular_component owl:Class
GO:1902493 biolink:NamedThing acetyltransferase complex A protein complex which is capable of acetyltransferase activity. got7fsn_ti bhm 2013-11-13T16:16:45Z cellular_component owl:Class
GO:0019875 biolink:NamedThing 6-aminohexanoate-dimer hydrolase activity Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate. got7fsn_ti N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity|6-aminohexanoic acid oligomer hydrolase activity RHEA:21364|EC:3.5.1.46|MetaCyc:RXN-3962|UM-BBD_enzymeID:e0673 molecular_function owl:Class
GO:0008653 biolink:NamedThing lipopolysaccharide metabolic process The chemical reactions and pathways involving lipopolysaccharides, a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. got7fsn_ti lipopolysaccharide metabolism|LPS metabolic process biological_process owl:Class
GO:0051271 biolink:NamedThing negative regulation of cellular component movement Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component. got7fsn_ti negative regulation of cellular component motion biological_process owl:Class
GO:0036472 biolink:NamedThing suppression by virus of host protein-protein interaction Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins. got7fsn_ti suppression by virus of host protein:protein binding|suppression by virus of host protein interaction|suppression by virus of host protein binding|suppression by virus of host protein:protein interaction bf 2014-07-21T11:18:51Z biological_process owl:Class
GO:0050073 biolink:NamedThing macrolide 2'-kinase activity Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H(+) + oleandomycin 2'-O-phosphate. got7fsn_ti ATP:macrolide 2'-O-phosphotransferase activity KEGG_REACTION:R03780|MetaCyc:MACROLIDE-2-KINASE-RXN|EC:2.7.1.136|RHEA:18333 molecular_function owl:Class
GO:0050099 biolink:NamedThing methylglutamate dehydrogenase activity Catalysis of the reaction: N-methyl-L-glutamate + A + H(2)O = L-glutamate + AH(2) + formaldehyde. got7fsn_ti N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating)|N-methyl-L-glutamate:acceptor oxidoreductase (demethylating)|N-methylglutamate dehydrogenase activity MetaCyc:METHYLGUTAMATE-DEHYDROGENASE-RXN|RHEA:22572|KEGG_REACTION:R00609|EC:1.5.99.5 molecular_function owl:Class
GO:0051055 biolink:NamedThing negative regulation of lipid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids. got7fsn_ti negative regulation of lipogenesis|inhibition of lipid biosynthetic process|negative regulation of lipid synthesis|negative regulation of lipid biosynthesis|negative regulation of lipid formation|downregulation of lipid biosynthetic process|negative regulation of lipid anabolism|down regulation of lipid biosynthetic process|down-regulation of lipid biosynthetic process biological_process owl:Class
GO:0070246 biolink:NamedThing natural killer cell apoptotic process Any apoptotic process in a natural killer cell, a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation. got7fsn_ti NK cell apoptosis|natural killer cell apoptosis biological_process owl:Class
GO:0045548 biolink:NamedThing phenylalanine ammonia-lyase activity Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate. got7fsn_ti phe ammonia-lyase activity|PAL activity|phenylalanine ammonium-lyase activity|phenylalanine deaminase activity|L-phenylalanine ammonia-lyase activity EC:4.3.1.24|EC:4.3.1.25|RHEA:21384 molecular_function owl:Class
GO:0047967 biolink:NamedThing glycyrrhizinate beta-glucuronidase activity Catalysis of the reaction: glycyrrhizate + H(2)O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate. got7fsn_ti glycyrrhizin hydrolase activity|glycyrrhizinate glucuronosylhydrolase activity|glycyrrhizinic acid hydrolase activity|glycyrrhizinate b-glucuronidase activity|glycyrrhizin beta-hydrolase activity KEGG_REACTION:R03906|MetaCyc:GLYCYRRHIZINATE-BETA-GLUCURONIDASE-RXN|RHEA:17369|EC:3.2.1.128 molecular_function owl:Class
GO:0071169 biolink:NamedThing establishment of protein localization to chromatin The directed movement of a protein to a part of a chromosome that is organized into chromatin. got7fsn_ti establishment of protein localisation to chromatin mah 2009-11-20T11:52:43Z biological_process owl:Class
GO:0004417 biolink:NamedThing hydroxyethylthiazole kinase activity Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+). got7fsn_ti ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity|4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity|hydroxyethylthiazole kinase (phosphorylating) RHEA:24212|EC:2.7.1.50|MetaCyc:THIAZOLSYN3-RXN|KEGG_REACTION:R04448 molecular_function owl:Class
GO:0042367 biolink:NamedThing biotin catabolic process The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. got7fsn_ti biotin catabolism|biotin degradation|vitamin B7 catabolic process|vitamin H catabolic process|vitamin B7 catabolism|biotin breakdown|vitamin H catabolism biological_process owl:Class
GO:0005675 biolink:NamedThing transcription factor TFIIH holo complex A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex. got7fsn_ti holo TFIIH complex cellular_component owl:Class
GO:0034553 biolink:NamedThing mitochondrial respiratory chain complex II assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II, in the mitochondrial inner membrane. got7fsn_ti biological_process owl:Class
GO:0071245 biolink:NamedThing cellular response to carbon monoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus. got7fsn_ti mah 2009-12-03T02:44:43Z biological_process owl:Class
GO:0061612 biolink:NamedThing galactose to glucose-1-phosphate metabolic process The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate. got7fsn_ti dph 2014-04-04T08:18:49Z biological_process owl:Class
GO:0006012 biolink:NamedThing galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. got7fsn_ti galactose metabolism Wikipedia:Galactose biological_process owl:Class
GO:0097414 biolink:NamedThing classical Lewy body Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils. got7fsn_ti brainstem Lewy body pr 2012-11-06T16:27:41Z NIF_Subcellular:sao4749542545 cellular_component owl:Class
GO:0019714 biolink:NamedThing peptidyl-glutamine esterification The addition of an ester group to a glutamine residue in a protein. got7fsn_ti biological_process owl:Class
GO:0008574 biolink:NamedThing plus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. got7fsn_ti microtubule motor activity, plus-end-directed|kinesin activity|plus-end-directed ATP-dependent microtubule motor activity|ATP-dependent plus-end-directed microtubule motor activity|ATP-dependent microtubule motor activity, plus-end-directed|plus-end-directed kinesin ATPase activity|kinesin ATP phosphohydrolase (plus-end-directed) https://github.com/geneontology/go-ontology/issues/18664 MetaCyc:3.6.4.4-RXN|EC:5.6.1.3 molecular_function owl:Class
GO:0014033 biolink:NamedThing neural crest cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell. got7fsn_ti biological_process owl:Class
GO:0050006 biolink:NamedThing isomaltulose synthase activity Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose. got7fsn_ti sucrose glucosylmutase activity|isomaltulose synthetase activity|sucrose alpha-glucosyltransferase activity|trehalulose synthase activity RHEA:24032|EC:5.4.99.11|MetaCyc:ISOMALTULOSE-SYNTHASE-RXN molecular_function owl:Class
GO:0035712 biolink:NamedThing T-helper 2 cell activation The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti Th2 cell activation bf 2011-03-02T03:05:59Z biological_process owl:Class
GO:0047658 biolink:NamedThing alpha-amino-acid esterase activity Catalysis of the reaction: an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol. got7fsn_ti alpha-amino-acid-ester aminoacylhydrolase activity|alpha-amino acid ester hydrolase activity|alpha-amino-acid ester hydrolase activity|a-amino-acid esterase activity MetaCyc:ALPHA-AMINO-ACID-ESTERASE-RXN|RHEA:17241|EC:3.1.1.43|Reactome:R-HSA-6784959 molecular_function owl:Class
GO:0005690 biolink:NamedThing U4atac snRNP A ribonucleoprotein complex that contains small nuclear RNA U4atac, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U4atac snRNP, most of which remain associated with the U4atac snRNA both while the U4atac snRNP is free or assembled into the U4atac/U6atac complex or into a series of spliceosomal complexes. got7fsn_ti snRNP U4atac cellular_component owl:Class
GO:0030740 biolink:NamedThing inositol 3-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+). got7fsn_ti myo-inositol 1-O-methyltransferase activity|S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity|S-adenosylmethionine:myo-inositol 1-methyltransferase activity|myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)|myo-inositol 1-methyltransferase activity|inositol L-1-methyltransferase activity|S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN|EC:2.1.1.39|RHEA:18877|KEGG_REACTION:R01189 molecular_function owl:Class
GO:0034572 biolink:NamedThing monodemethylisoproturon dimethylaminedehydrogenase activity Catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-. got7fsn_ti EC:1.5.99.-|UM-BBD_reactionID:r0897 molecular_function owl:Class
GO:1990405 biolink:NamedThing protein antigen binding Binding to a protein antigen. got7fsn_ti pm 2014-06-30T13:19:55Z molecular_function owl:Class
GO:0014821 biolink:NamedThing phasic smooth muscle contraction A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations. got7fsn_ti biological_process owl:Class
GO:1990312 biolink:NamedThing type-II cohesin domain binding Binding to a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain. got7fsn_ti tt 2014-03-07T04:51:07Z molecular_function owl:Class
GO:0005824 biolink:NamedThing outer plaque of spindle pole body One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm. got7fsn_ti cellular_component owl:Class
GO:0071773 biolink:NamedThing cellular response to BMP stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bone morphogenetic protein (BMP) stimulus. got7fsn_ti cellular response to bone morphogenetic protein stimulus mah 2010-08-31T11:04:45Z biological_process owl:Class
GO:0102488 biolink:NamedThing dTTP phosphohydrolase activity Catalysis of the reaction: dTTP + 2 H2O = dTMP + 2 hydrogenphosphate + 2 H+. got7fsn_ti MetaCyc:RXN-14200|EC:3.6.1.5 molecular_function owl:Class
GO:0032634 biolink:NamedThing interleukin-5 production The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-5 biosynthetic process|interleukin-5 secretion|IL-5 production GO:0072603|GO:0042225 biological_process owl:Class
GO:0047770 biolink:NamedThing carboxylate reductase activity Catalysis of the reaction: an aldehyde + acceptor + H2O = a carboxylate + reduced acceptor. got7fsn_ti carboxylic acid reductase activity|aldehyde:(acceptor) oxidoreductase activity|aldehyde:acceptor oxidoreductase activity MetaCyc:CARBOXYLATE-REDUCTASE-RXN|EC:1.2.99.6 molecular_function owl:Class
GO:1990362 biolink:NamedThing butanol dehydrogenase activity Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+. got7fsn_ti tt 2014-04-23T21:14:09Z RHEA:33199 molecular_function owl:Class
GO:0047960 biolink:NamedThing glycine dehydrogenase activity Catalysis of the reaction: glycine + H2O + NAD+ = glyoxylate + NH3 + NADH. got7fsn_ti glycine:NAD+ oxidoreductase (deaminating) EC:1.4.1.10|MetaCyc:GLYCINE-DEHYDROGENASE-RXN|RHEA:15721 molecular_function owl:Class
GO:0070836 biolink:NamedThing caveola assembly The aggregation, arrangement and bonding together of a set of components to form a caveola. A caveola is a plasma membrane raft that forms a small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. got7fsn_ti caveolar biogenesis|caveola formation mah 2009-07-30T04:45:54Z biological_process owl:Class
GO:0038152 biolink:NamedThing C-C chemokine receptor CCR4 signaling pathway A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti chemokine receptor CCR4 signaling pathway|C-C chemokine receptor type 4 signaling pathway bf 2012-05-11T11:43:34Z biological_process owl:Class
GO:0071787 biolink:NamedThing endoplasmic reticulum tubular network formation The aggregation, arrangement and bonding together of a set of components to form the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that comprises the membranes with high curvature in cross-section. got7fsn_ti endoplasmic reticulum tubular network assembly|ER tubular network formation|ER tubular network assembly mah 2010-09-01T01:54:29Z biological_process owl:Class
GO:0016040 biolink:NamedThing glutamate synthase (NADH) activity Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH. got7fsn_ti L-glutamate synthetase activity|glutamate (reduced nicotinamide adenine dinucleotide) synthase|L-glutamate:NAD+ oxidoreductase (transaminating)|L-glutamate synthase (NADH)|NADH: GOGAT|L-glutamate synthase activity|GOGAT activity|NADH-dependent glutamate synthase activity|NADH-glutamate synthase activity RHEA:13753|KEGG_REACTION:R00093|MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN|EC:1.4.1.14 molecular_function owl:Class
GO:0018770 biolink:NamedThing 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+. got7fsn_ti UM-BBD_reactionID:r0444 molecular_function owl:Class
GO:0061799 biolink:NamedThing cyclic pyranopterin monophosphate synthase activity Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate. got7fsn_ti dph 2016-10-06T14:36:56Z MetaCyc:RXN-17809|EC:4.6.1.17|RHEA:49580 molecular_function owl:Class
GO:0102264 biolink:NamedThing tRNA-dihydrouridine20 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil20 in tRNA + NAD(P) <=> H+ + a uracil20 in tRNA + NAD(P)H. got7fsn_ti EC:1.3.1.91|MetaCyc:RXN-12456 molecular_function owl:Class
GO:0033454 biolink:NamedThing GCC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GCC codon. got7fsn_ti alanine tRNA Note that in the standard genetic code, GCC codes for alanine. molecular_function owl:Class
GO:0009052 biolink:NamedThing pentose-phosphate shunt, non-oxidative branch The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. got7fsn_ti pentose-phosphate pathway, non-oxidative branch|pentose phosphate shunt, non-oxidative branch|pentose phosphate pathway, non-oxidative branch MetaCyc:NONOXIPENT-PWY|MetaCyc:P21-PWY biological_process owl:Class
GO:0048535 biolink:NamedThing lymph node development The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes. got7fsn_ti lymph gland development biological_process owl:Class
GO:0060337 biolink:NamedThing type I interferon signaling pathway A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti type I interferon-mediated signaling pathway|type I interferon-activated signaling pathway|type I interferon-mediated signalling pathway biological_process owl:Class
GO:0097600 biolink:NamedThing exoxylanase activity A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains. got7fsn_ti pr 2014-05-06T13:48:27Z molecular_function owl:Class
GO:0048391 biolink:NamedThing intermediate mesoderm formation The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts. got7fsn_ti biological_process owl:Class
GO:0035641 biolink:NamedThing locomotory exploration behavior The specific movement from place to place of an organism in response to a novel environment. got7fsn_ti bf 2011-01-19T10:40:04Z biological_process owl:Class
GO:0019585 biolink:NamedThing glucuronate metabolic process The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. got7fsn_ti glucuronate metabolism GO:0019699 Wikipedia:Glucuronic_acid biological_process owl:Class
GO:0072572 biolink:NamedThing poly-ADP-D-ribose binding Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. got7fsn_ti poly-ADP-ribose binding|pADPr binding mah 2011-01-31T02:49:04Z molecular_function owl:Class
GO:0042803 biolink:NamedThing protein homodimerization activity Binding to an identical protein to form a homodimer. got7fsn_ti dimerization activity molecular_function owl:Class
GO:0036296 biolink:NamedThing response to increased oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. got7fsn_ti response to raised oxygen levels This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'response to hyperoxia ; GO:0055093. bf 2012-07-20T01:10:48Z biological_process owl:Class
GO:2001005 biolink:NamedThing positive regulation of pectin catabolic process Any process that activates or increases the frequency, rate or extent of pectin catabolic process. got7fsn_ti positive regulation of pectin breakdown|positive regulation of pectin catabolism|positive regulation of pectin degradation tt 2011-08-08T03:24:09Z biological_process owl:Class
GO:0050216 biolink:NamedThing propanediol-phosphate dehydrogenase activity Catalysis of the reaction: NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH. got7fsn_ti EC:1.1.1.7|KEGG_REACTION:R04236|MetaCyc:PROPANEDIOL-PHOSPHATE-DEHYDROGENASE-RXN|RHEA:21584 molecular_function owl:Class
GO:0042968 biolink:NamedThing homoserine transport The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0031679 biolink:NamedThing NADH dehydrogenase (plastoquinone) activity Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol. got7fsn_ti NADH:plastoquinone reductase activity GO:0030024 molecular_function owl:Class
GO:0042051 biolink:NamedThing compound eye photoreceptor development The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure. got7fsn_ti adult eye photoreceptor development biological_process owl:Class
GO:0043396 biolink:NamedThing corticotropin-releasing hormone secretion The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle. got7fsn_ti CRF secretion|CRH secretion|corticotropin-releasing factor secretion biological_process owl:Class
GO:2000194 biolink:NamedThing regulation of female gonad development Any process that modulates the frequency, rate or extent of female gonad development. got7fsn_ti regulation of ovarian development|regulation of ovary development yaf 2010-10-19T10:45:34Z biological_process owl:Class
GO:0046422 biolink:NamedThing violaxanthin de-epoxidase activity Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; and antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O. got7fsn_ti violaxanthin:ascorbate oxidoreductase activity|VDE RHEA:32371|EC:1.23.5.1 molecular_function owl:Class
GO:0005313 biolink:NamedThing L-glutamate transmembrane transporter activity Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. got7fsn_ti glutamate/aspartate:sodium symporter activity|glutamate/aspartate porter activity|L-glutamate transporter activity Reactome:R-HSA-5624256|Reactome:R-HSA-428052|Reactome:R-HSA-210444 molecular_function owl:Class
GO:0070147 biolink:NamedThing mitochondrial cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA in a mitochondrion, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0120166 biolink:NamedThing protoperithecium formation The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium. got7fsn_ti Note that this term represents protoperithecium formation across homothallic and heterothallic species that do not have the same mechanism. krc 2018-05-17T17:27:16Z biological_process owl:Class
GO:0042743 biolink:NamedThing hydrogen peroxide metabolic process The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. got7fsn_ti hydrogen peroxide metabolism|H2O2 metabolic process biological_process owl:Class
GO:0002129 biolink:NamedThing wobble position guanine ribose methylation The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position. got7fsn_ti biological_process owl:Class
GO:0002938 biolink:NamedThing tRNA guanine ribose methylation The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety. got7fsn_ti hjd 2012-11-02T15:55:55Z biological_process owl:Class
GO:0018170 biolink:NamedThing C-terminal peptidyl-polyglutamic acid amidation The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus. got7fsn_ti RESID:AA0261 biological_process owl:Class
GO:0051779 biolink:NamedThing gibberellin 12-aldehyde oxidase activity Catalysis of the reaction: gibberellin 12-aldehyde + NADPH + H+ + O2 = gibberellin 12 + NADP+ + H2O. This is the third of three successive reactions resulting in the oxidation of ent-kaurenoate (ent-kaurenoic acid) to gibberellin 12 (GA12). got7fsn_ti GA12-aldehyde oxidase activity Note that the enzyme ent-kaurenoate oxidase also catalyzes the reactions represented by the molecular function terms 'ent-kaurenoate oxidase activity ; GO:0051777' and 'ent-7-alpha-hydroxykaurenoate oxidase activity ; GO:0051778'. RHEA:22700|MetaCyc:RXN1F-161 molecular_function owl:Class
GO:0061350 biolink:NamedThing planar cell polarity pathway involved in cardiac muscle tissue morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the cardiac muscle tissue. got7fsn_ti dph 2010-10-01T10:57:33Z biological_process owl:Class
GO:0044720 biolink:NamedThing negative regulation of imaginal disc-derived wing size Any process that reduces the size of an imaginal disc-derived wing. got7fsn_ti jl 2012-10-18T13:50:49Z biological_process owl:Class
GO:0018749 biolink:NamedThing (3,5-dichlorophenylurea)acetate amidohydrolase activity Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine. got7fsn_ti UM-BBD_reactionID:r0708 molecular_function owl:Class
GO:0070852 biolink:NamedThing cell body fiber A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches. got7fsn_ti cell body fibre|primary neurite mah 2009-08-11T04:38:53Z cellular_component owl:Class
GO:0015565 biolink:NamedThing threonine efflux transmembrane transporter activity Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti threonine efflux permease activity|threonine export protein|threonine export transporter activity molecular_function owl:Class
GO:0034639 biolink:NamedThing L-amino acid efflux transmembrane transporter activity Enables the transfer of an L-amino acid from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti L-amino acid export transporter activity|L-amino acid efflux permease activity molecular_function owl:Class
GO:0097491 biolink:NamedThing sympathetic neuron projection guidance The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti sympathetic neuronal cell projection guidance|sympathetic neurite guidance|sympathetic neuron protrusion guidance|sympathetic neuron process guidance pr 2013-07-10T11:49:21Z biological_process owl:Class
GO:0015932 biolink:NamedThing nucleobase-containing compound transmembrane transporter activity Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. got7fsn_ti nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity molecular_function owl:Class
GO:0018462 biolink:NamedThing 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH. got7fsn_ti 4-sulfobenzyl alcohol dehydrogenase activity|4-(hydroxymethyl)benzenesulphonate dehydrogenase activity|4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity EC:1.1.1.257|UM-BBD_reactionID:r0291|RHEA:24412|KEGG_REACTION:R05271|MetaCyc:1.1.1.257-RXN molecular_function owl:Class
GO:0045851 biolink:NamedThing pH reduction Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. got7fsn_ti acidification biological_process owl:Class
GO:0019800 biolink:NamedThing peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain. got7fsn_ti peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan RESID:AA0219 biological_process owl:Class
GO:0047983 biolink:NamedThing homoglutathione synthase activity Catalysis of the reaction: beta-alanine + L-gamma-glutamyl-L-cysteine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + 2 H(+) + phosphate. got7fsn_ti beta-alanine specific hGSH synthetase activity|homoglutathione synthetase activity|gamma-L-glutamyl-L-cysteine:beta-alanine ligase (ADP-forming) EC:6.3.2.23|MetaCyc:HOMOGLUTATHIONE-SYNTHASE-RXN|RHEA:17993|KEGG_REACTION:R02741 molecular_function owl:Class
GO:0090282 biolink:NamedThing positive regulation of transcription involved in G2/M transition of mitotic cell cycle Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle|positive regulation of G2/M-specific transcription in the mitotic cell cycle|up-regulation of transcription involved in G2/M transition of mitotic cell cycle|activation of transcription from RNA polymerase II promoter during G2/M-phase of the mitotic cell cycle|up-regulation of transcription from RNA polymerase II promoter during G2/M transition of the mitotic cell cycle|up-regulation of G2/M-specific transcription in the mitotic cell cycle|activation of G2/M-specific transcription in the mitotic cell cycle|activation of transcription involved in G2/M transition of mitotic cell cycle tb 2010-02-09T02:13:26Z biological_process owl:Class
GO:0043810 biolink:NamedThing ornithine-acyl [acyl carrier protein] N-acyltransferase activity Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids. got7fsn_ti L-ornithine N(alpha)-acyltransferase|ornithine-acyl[acyl carrier protein] N-acyltransferase activity RHEA:20633|EC:2.3.2.30 molecular_function owl:Class
GO:0097020 biolink:NamedThing COPII receptor activity Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20002 pr 2011-03-24T04:19:55Z molecular_function owl:Class
GO:1990342 biolink:NamedThing heterochromatin island A region of facultative heterochromatin formed dynamically at specific loci in response to environmental signals, independently of RNAi. got7fsn_ti https://github.com/geneontology/go-ontology/issues/11247 An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin islands are formed at meiotic genes during vegetative (mitotic) growth. mah 2014-03-21T15:26:44Z cellular_component owl:Class
GO:0021930 biolink:NamedThing cerebellar granule cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0009835 biolink:NamedThing fruit ripening An aging process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal. got7fsn_ti fruit senescence|fruit maturation Wikipedia:Ripening biological_process owl:Class
GO:0014732 biolink:NamedThing skeletal muscle atrophy A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse. got7fsn_ti biological_process owl:Class
GO:0016403 biolink:NamedThing dimethylargininase activity Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. got7fsn_ti NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity|NG,NG-dimethylarginine dimethylaminohydrolase activity|dimethylarginine dimethylaminohydrolase activity|N(G),N(G)-dimethylarginine dimethylaminohydrolase activity Reactome:R-HSA-5693373|MetaCyc:DIMETHYLARGININASE-RXN|EC:3.5.3.18|RHEA:17305 molecular_function owl:Class
GO:0065005 biolink:NamedThing protein-lipid complex assembly The aggregation, arrangement and bonding together of proteins and lipids to form a protein-lipid complex. got7fsn_ti biological_process owl:Class
GO:0003844 biolink:NamedThing 1,4-alpha-glucan branching enzyme activity Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain. got7fsn_ti 1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity|alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity|branching enzyme activity|branching glycosyltransferase activity|amylose isomerase activity|amylo-(1,4 to 1,6)transglucosidase activity|amylo-(1,4->1,6)-transglycosylase activity|enzymatic branching factor|glycogen branching enzyme activity|Q-enzyme|glucosan transglycosylase activity|enzyme Q|starch branching enzyme|alpha-glucan-branching glycosyltransferase activity|1,4-glucan-6-(1,4-glucano)-transferase activity|plant branching enzyme Reactome:R-HSA-3878762|Reactome:R-HSA-3322016|Reactome:R-HSA-3322057|Reactome:R-HSA-3322005|MetaCyc:GLYCOGEN-BRANCH-RXN|EC:2.4.1.18 molecular_function owl:Class
GO:0072137 biolink:NamedThing condensed mesenchymal cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a condensed mesenchymal cell population. A condensed mesenchymal cell population is a population of adherent mesenchymal cells. got7fsn_ti mah 2010-02-22T02:38:54Z biological_process owl:Class
GO:0018569 biolink:NamedThing hydroquinone 1,2-dioxygenase activity Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde. got7fsn_ti UM-BBD_reactionID:r0228|EC:1.13.11.- molecular_function owl:Class
GO:0090016 biolink:NamedThing regulation of leaflet formation Any process that modulates the frequency, rate or extent of leaflet formation. got7fsn_ti tb 2009-07-29T11:23:48Z biological_process owl:Class
GO:0000444 biolink:NamedThing MIS12/MIND type complex A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1. got7fsn_ti Mis12 complex cellular_component owl:Class
GO:0046134 biolink:NamedThing pyrimidine nucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). got7fsn_ti pyrimidine nucleoside formation|pyrimidine nucleoside synthesis|pyrimidine nucleoside biosynthesis|pyrimidine nucleoside anabolism biological_process owl:Class
GO:0010782 biolink:NamedThing proboscis morphogenesis, labial disc-derived The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized. got7fsn_ti biological_process owl:Class
GO:0042366 biolink:NamedThing cobalamin catabolic process The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. got7fsn_ti vitamin B12 catabolism|cobalamin breakdown|cobalamin catabolism|cobalamin degradation|vitamin B12 catabolic process biological_process owl:Class
GO:0007041 biolink:NamedThing lysosomal transport The directed movement of substances into, out of or within a lysosome. got7fsn_ti biological_process owl:Class
GO:0003120 biolink:NamedThing regulation of vasoconstriction by circulating epinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream. got7fsn_ti regulation of vasoconstriction by circulating adrenaline biological_process owl:Class
GO:0034686 biolink:NamedThing integrin alphav-beta8 complex An integrin complex that comprises one alphav subunit and one beta8 subunit. got7fsn_ti alphav-beta8 integrin complex|ITGAV-ITGB8 complex cellular_component owl:Class
GO:0102357 biolink:NamedThing mithramycin dehydrogenase activity Catalysis of the reaction: mithramycin + NADP <=> mithramycin DK + NADPH + H+. got7fsn_ti MetaCyc:RXN-13385 molecular_function owl:Class
GO:0070535 biolink:NamedThing histone H2A K63-linked ubiquitination A histone ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a lysine residue in histone H2A or the variant H2AX. got7fsn_ti biological_process owl:Class
GO:0070534 biolink:NamedThing protein K63-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair. got7fsn_ti protein K63-linked polyubiquitination biological_process owl:Class
GO:0034963 biolink:NamedThing box C/D RNA processing Any process involved in the conversion of a primary box C/D type small RNA transcript into a mature box C/D RNA. got7fsn_ti box C/D sRNA processing|box C/D snoRNA processing https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0031612 biolink:NamedThing cytosolic proteasome regulatory particle, base subcomplex The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell. got7fsn_ti cellular_component owl:Class
GO:0001116 biolink:NamedThing protein-DNA-RNA complex assembly The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex. got7fsn_ti krc 2010-12-03T04:01:38Z biological_process owl:Class
GO:0001115 biolink:NamedThing protein-DNA-RNA complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex. got7fsn_ti protein-DNA-RNA complex subunit organisation krc 2010-12-03T04:00:02Z biological_process owl:Class
GO:0061646 biolink:NamedThing positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter. got7fsn_ti dph 2014-10-02T14:18:49Z biological_process owl:Class
GO:0071144 biolink:NamedThing heteromeric SMAD protein complex A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric. got7fsn_ti SMAD2-SMAD3-SMAD4 protein complex|SMAD3-SMAD4 protein complex|SMAD1-SMAD4 protein complex|SMAD2-SMAD4 protein complex 2009-11-16T02:44:37Z GO:0071145|GO:0071146 cellular_component owl:Class
GO:0072344 biolink:NamedThing rescue of stalled ribosome A process of translational elongation that takes place when a ribosome has stalled during translation, and results in freeing the ribosome from the stalled translation complex. got7fsn_ti mah 2010-11-10T11:54:26Z biological_process owl:Class
GO:0102294 biolink:NamedThing cholesterol dehydrogenase activity Catalysis of the reaction: cholesterol + NAD = cholest-5-en-3-one + NADH + H+. got7fsn_ti MetaCyc:RXN-12693|RHEA:35459|EC:1.1.1.145 molecular_function owl:Class
GO:0016875 biolink:NamedThing ligase activity, forming carbon-oxygen bonds Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti EC:6.1.-.- molecular_function owl:Class
GO:0043995 biolink:NamedThing histone acetyltransferase activity (H4-K5 specific) Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5). got7fsn_ti histone lysine N-acetyltransferase activity (H4-K5 specific) molecular_function owl:Class
GO:0048911 biolink:NamedThing efferent axon development in anterior lateral line nerve The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0018935 biolink:NamedThing aerobic nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen. got7fsn_ti aerobic nitrilotriacetate metabolism biological_process owl:Class
GO:0072316 biolink:NamedThing alpha-glucan catabolic process involved in ascospore release from ascus The chemical reactions and pathways resulting in the breakdown of alpha-glucans in the ascus wall that contributes to the release of ascospores from the ascus. got7fsn_ti alpha-glucan catabolism involved in ascospore release from ascus|alpha-glucan degradation involved in ascospore release from ascus|alpha-glucan breakdown involved in ascospore release from ascus mah 2010-10-25T05:43:52Z biological_process owl:Class
GO:0072000 biolink:NamedThing extracellular polysaccharide catabolic process involved in ascospore release from ascus The chemical reactions and pathways resulting in the breakdown of polysaccharides in the ascus wall that contributes to the release of ascospores from the ascus. got7fsn_ti extracellular polysaccharide degradation involved in ascospore release from ascus|ascus endolysis|extracellular polysaccharide catabolism involved in ascospore release from ascus|ascus catabolic process|extracellular polysaccharide breakdown involved in ascospore release from ascus mah 2010-10-25T05:30:41Z biological_process owl:Class
GO:0032798 biolink:NamedThing Swi5-Sfr1 complex A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces). got7fsn_ti Swi5 complex|Sae3-Mei5 complex Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p. cellular_component owl:Class
GO:0018757 biolink:NamedThing deisopropylhydroxyatrazine aminohydrolase activity Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine. got7fsn_ti UM-BBD_reactionID:r0121|KEGG_REACTION:R05574 molecular_function owl:Class
GO:0047471 biolink:NamedThing maltose alpha-D-glucosyltransferase activity Catalysis of the reaction: maltose = trehalose. got7fsn_ti trehalose synthase activity|maltose glucosylmutase activity|maltose alpha-D-glucosylmutase activity EC:5.4.99.16|MetaCyc:5.4.99.16-RXN|RHEA:15145 molecular_function owl:Class
GO:0102992 biolink:NamedThing 2-methylbutyronitrile hydroxylase activity Catalysis of the reaction: H+ + 2-methylbutyronitrile + NADPH + O2 <=> H2O + NADP + 2-hydroxy-2-methylbutyronitrile. got7fsn_ti RHEA:51948|MetaCyc:RXN-9642 molecular_function owl:Class
GO:0006283 biolink:NamedThing transcription-coupled nucleotide-excision repair The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway. got7fsn_ti transcription-coupled NER|transcription-coupled repair|TC-NER|TCR biological_process owl:Class
GO:0032219 biolink:NamedThing cell wall macromolecule catabolic process involved in cytogamy The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy. got7fsn_ti cell wall macromolecule catabolic process during cytogamy biological_process owl:Class
GO:0102093 biolink:NamedThing acrylate:acyl-coA CoA transferase activity Catalysis of the reaction: acryloyl-CoA + H2O <=> acrylate + coenzyme A + H+. got7fsn_ti MetaCyc:RXN-10985 molecular_function owl:Class
GO:0035385 biolink:NamedThing Roundabout signaling pathway A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti Roundabout signalling pathway|ROBO signaling pathway|ROBO/SLIT signaling pathway bf 2010-03-18T02:38:31Z biological_process owl:Class
GO:0051502 biolink:NamedThing diterpene phytoalexin biosynthetic process The chemical reactions and pathways resulting in the formation of diterpene phytoalexins, terpenoids with 20 carbons produced by plants in response to environmental stresses. got7fsn_ti diterpene phytoalexin formation|diterpene phytoalexin biosynthesis|diterpene phytoalexin anabolism|diterpene phytoalexin synthesis biological_process owl:Class
GO:0033068 biolink:NamedThing macrolide biosynthetic process The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria. got7fsn_ti macrolide biosynthesis|macrolide anabolism|macrolide formation|macrolide synthesis biological_process owl:Class
GO:0052634 biolink:NamedThing C-19 gibberellin 2-beta-dioxygenase activity Catalysis of the reaction: a C-19 gibberellin + 2-oxoglutarate + O2 = a C-19 2-beta-hydroxygibberellin + succinate + CO2. C-19 gibberellin refers to a gibberellin with nineteen carbons. got7fsn_ti C-19 gibberellin 2-beta-hydroxylase activity|C-19 gibberellin 2-oxidase activity|C-19 gibberellin 2beta-hydroxylase activity|C-19 GA 2-oxidase activity|(C-19 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)|C-19 gibberellin 2beta-dioxygenase activity|C(19) gibberellin 2-oxidase activity EC:1.14.11.13 molecular_function owl:Class
GO:0102119 biolink:NamedThing gibberellin A20 carboxyl methyltransferase activity Catalysis of the reaction: gibberellin A20 + S-adenosyl-L-methionine <=> gibberellin A20 methyl ester + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-11360 molecular_function owl:Class
GO:0071201 biolink:NamedThing Kv4.3-DPP6 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.3. got7fsn_ti Kv4.3-DPPX channel complex mah 2009-11-23T05:20:54Z CORUM:599 cellular_component owl:Class
GO:0044516 biolink:NamedThing positive regulation of glucagon-like peptide receptor 1 activity in other organism A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism. got7fsn_ti jl 2012-02-26T11:09:44Z biological_process owl:Class
GO:0016259 biolink:NamedThing selenocysteine metabolic process The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins. got7fsn_ti selenocysteine metabolism biological_process owl:Class
GO:0047430 biolink:NamedThing oligosaccharide-diphosphodolichol diphosphatase activity Catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate. got7fsn_ti oligosaccharide-diphosphodolichol phosphodolichohydrolase activity|oligosaccharide-diphosphodolichol pyrophosphatase activity MetaCyc:3.6.1.44-RXN|RHEA:15205|EC:3.6.1.44 molecular_function owl:Class
GO:0030746 biolink:NamedThing isoflavone 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone. got7fsn_ti isoflavone methyltransferase activity|4'-hydroxyisoflavone methyltransferase activity|isoflavone O-methyltransferase activity|S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity RHEA:31739|EC:2.1.1.46|MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0032843 biolink:NamedThing hydroperoxide reductase activity Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol. got7fsn_ti molecular_function owl:Class
GO:0140665 biolink:NamedThing ATP-dependent H3-H4 histone complex loader activity Loading of a histone H3-H4 complex onto DNA, driven by ATP hydrolysis. got7fsn_ti H3-H4 dimer loading activity|H3-H4 histone complex loader activity|histone H3-H4 dimer loading activity|histone chaperone|H3-H4 histone chaperone https://github.com/geneontology/go-ontology/issues/21733|https://github.com/geneontology/go-ontology/issues/21580 pg 2021-06-22T13:57:16Z molecular_function owl:Class
GO:0140674 biolink:NamedThing ATP-dependent histone loader activity Depositing a histone or a histone complex onto DNA. got7fsn_ti histone loader activity|histone loading activity https://github.com/geneontology/go-ontology/issues/21733 pg 2021-06-29T12:42:57Z molecular_function owl:Class
GO:0052747 biolink:NamedThing sinapyl alcohol dehydrogenase activity Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+. got7fsn_ti sinapyl-alcohol:NADP+ oxidoreductase activity|sinapyl-alcohol dehydrogenase activity 2011-09-21T12:42:06Z MetaCyc:RXN-1125|EC:1.1.1.195|RHEA:45704|KEGG_REACTION:R03918 molecular_function owl:Class
GO:0000254 biolink:NamedThing C-4 methylsterol oxidase activity Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O. got7fsn_ti 4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)|methylsterol monooxygenase activity|methylsterol hydroxylase activity|4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)|4-methylsterol oxidase activity Note that zymosterol is cholesta-8,24-dien-3-ol. RHEA:55220|Reactome:R-HSA-194641|EC:1.14.18.9|MetaCyc:1.14.13.72-RXN|Reactome:R-HSA-194669 molecular_function owl:Class
GO:0030283 biolink:NamedThing testosterone dehydrogenase [NAD(P)] activity Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. got7fsn_ti 17beta-hydroxy steroid dehydrogenase|beta-hydroxy steroid dehydrogenase|3beta-hydroxysteroid dehydrogenase|3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase|3(or 17)beta-hydroxysteroid dehydrogenase activity|3beta-hydroxy steroid dehydrogenase MetaCyc:1.1.1.51-RXN|Reactome:R-HSA-193064|EC:1.1.1.51 molecular_function owl:Class
GO:0008772 biolink:NamedThing [isocitrate dehydrogenase (NADP+)] kinase activity Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate. got7fsn_ti IDH-K/P|IDHK/P|isocitrate dehydrogenase (NADP+) kinase activity|ICDH kinase/phosphatase activity|ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity|isocitrate dehydrogenase kinase (phosphorylating) activity|isocitrate dehydrogenase kinase/phosphatase activity|isocitrate dehydrogenase (NADP) kinase activity|isocitrate dehydrogenase kinase activity|IDH kinase/phosphatase activity|IDH kinase activity RHEA:43540|MetaCyc:PHOSICITDEHASE-RXN|EC:2.7.11.5 molecular_function owl:Class
GO:0044566 biolink:NamedThing chondrocyte activation A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage. got7fsn_ti jl 2012-04-05T04:45:38Z biological_process owl:Class
GO:0004456 biolink:NamedThing phosphogluconate dehydratase activity Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O. got7fsn_ti gluconate 6-phosphate dehydratase activity|6-phosphogluconate dehydratase activity|6-phosphogluconic dehydrase activity|gluconate-6-phosphate dehydratase activity|6-phosphogluconate dehydrase activity|6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)|6-phospho-D-gluconate hydro-lyase activity RHEA:17277|EC:4.2.1.12|MetaCyc:PGLUCONDEHYDRAT-RXN|KEGG_REACTION:R02036 molecular_function owl:Class
GO:1900798 biolink:NamedThing cordyol C catabolic process The chemical reactions and pathways resulting in the breakdown of cordyol C. got7fsn_ti cordyol C degradation|cordyol C catabolism|cordyol C breakdown di 2012-06-04T09:48:10Z biological_process owl:Class
GO:0019154 biolink:NamedThing glycolate dehydrogenase activity Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate. got7fsn_ti glycolate:acceptor 2-oxidoreductase activity|glycolic acid dehydrogenase activity|glycolate oxidoreductase activity|glycolate:(acceptor) 2-oxidoreductase activity RHEA:21264|EC:1.1.99.14|MetaCyc:GLYCOLATEDEHYDRO-RXN|KEGG_REACTION:R00476 molecular_function owl:Class
GO:0050610 biolink:NamedThing methylarsonate reductase activity Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid. got7fsn_ti glutathione:methylarsonate oxidoreductase activity|MMA(V) reductase activity RHEA:15969|KEGG_REACTION:R05748|MetaCyc:1.20.4.2-RXN|Reactome:R-HSA-5696230|EC:1.20.4.2|UM-BBD_reactionID:r0837 molecular_function owl:Class
GO:0102760 biolink:NamedThing 6-deoxocathasterone hydroxylase activity Catalysis of the reaction: 6-deoxycathasterone + O2 + a reduced electron acceptor <=> 6-deoxoteasterone + H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-774 molecular_function owl:Class
GO:0002476 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class Ib The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class Ib biological_process owl:Class
GO:0035946 biolink:NamedThing mitochondrial mRNA surveillance The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion. got7fsn_ti mitochondrial aberrant RNA catabolic process|mitochondrial mRNA quality control|mitochondrial messenger RNA surveillance bf 2011-07-28T10:37:07Z biological_process owl:Class
GO:0034952 biolink:NamedThing malonate semialdehyde decarboxylase activity Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2. got7fsn_ti UM-BBD_reactionID:r0266 molecular_function owl:Class
GO:0008663 biolink:NamedThing 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate. got7fsn_ti cyclic phosphodiesterase:3'-nucleotidase activity|cyclic 2',3'-nucleotide 2'-phosphodiesterase activity|nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity|ribonucleoside 2',3'-cyclic phosphate diesterase activity|2',3 '-cyclic AMP phosphodiesterase activity|2',3'-cyclic AMP 2'-phosphohydrolase activity|2':3'-cyclic phosphodiesterase activity|cyclic 2',3'-nucleotide phosphodiesterase|2',3'-cyclic nucleoside monophosphate phosphodiesterase|2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity|2',3'-cyclic nucleotide phosphohydrolase|2',3'-cyclic nucleotidase activity EC:3.1.4.16|MetaCyc:CYCPHOSDIESTER-RXN|RHEA:19621 molecular_function owl:Class
GO:0016027 biolink:NamedThing inaD signaling complex A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD. got7fsn_ti inaD signalling complex cellular_component owl:Class
GO:0008879 biolink:NamedThing glucose-1-phosphate thymidylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. got7fsn_ti dTDP-glucose pyrophosphorylase activity|glucose 1-phosphate thymidylyltransferase activity|TDP-glucose pyrophosphorylase activity|dTDP-glucose synthase activity|thymidine diphosphoglucose pyrophosphorylase activity|dTDP-glucose diphosphorylase activity|dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity|thymidine diphosphate glucose pyrophosphorylase activity EC:2.7.7.24|RHEA:15225|KEGG_REACTION:R02328|MetaCyc:DTDPGLUCOSEPP-RXN molecular_function owl:Class
GO:0033920 biolink:NamedThing 6-phospho-beta-galactosidase activity Catalysis of the reaction: a 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. got7fsn_ti phospho-beta-D-galactosidase activity|beta-D-phosphogalactoside galactohydrolase activity|6-phospho-beta-D-galactoside 6-phosphogalactohydrolase activity|6-phospho-beta-D-galactosidase activity|phospho-beta-galactosidase activity RHEA:24568|MetaCyc:6-PHOSPHO-BETA-GALACTOSIDASE-RXN|EC:3.2.1.85 molecular_function owl:Class
GO:0008537 biolink:NamedThing proteasome activator complex A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex. got7fsn_ti PA28 cellular_component owl:Class
GO:0005900 biolink:NamedThing oncostatin-M receptor complex A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta. got7fsn_ti cellular_component owl:Class
GO:0000110 biolink:NamedThing nucleotide-excision repair factor 1 complex One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively. got7fsn_ti XPA-ERCC1-ERCC4 complex|NEF1 complex Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. cellular_component owl:Class
GO:0038145 biolink:NamedThing macrophage colony-stimulating factor signaling pathway A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti macrophage colony-stimulating factor signalling pathway|M-CSF signaling pathway bf 2012-04-27T11:04:18Z biological_process owl:Class
GO:0008790 biolink:NamedThing arabinose isomerase activity Catalysis of the reaction: D-arabinose = D-ribulose. got7fsn_ti D-arabinose ketol-isomerase activity|D-arabinose(L-fucose) isomerase activity|D-arabinose aldose-ketose-isomerase activity|D-arabinose isomerase activity MetaCyc:DARABISOM-RXN|EC:5.3.1.3|RHEA:13849 molecular_function owl:Class
GO:0018227 biolink:NamedThing peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine. got7fsn_ti peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine|peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine RESID:AA0103 biological_process owl:Class
GO:0004073 biolink:NamedThing aspartate-semialdehyde dehydrogenase activity Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH. got7fsn_ti ASA dehydrogenase activity|L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)|L-aspartate-beta-semialdehyde dehydrogenase activity|aspartic beta-semialdehyde dehydrogenase activity|L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)|aspartic semialdehyde dehydrogenase activity|aspartate semialdehyde dehydrogenase activity RHEA:24284|MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN|KEGG_REACTION:R02291|EC:1.2.1.11 molecular_function owl:Class
GO:0002069 biolink:NamedThing columnar/cuboidal epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube. got7fsn_ti biological_process owl:Class
GO:0051712 biolink:NamedThing positive regulation of killing of cells of other organism Any process that activates or increases the frequency, rate or extent of the killing by an organism of cells in another organism. got7fsn_ti upregulation of killing of cells of another organism|induction by organism of apoptosis in other organism involved in symbiotic interaction|induction by organism of apoptosis in other organism during symbiotic interaction|enhancement of other organism programmed cell death by organism|stimulation of killing of cells of another organism|positive regulation by organism of non-apoptotic programmed cell death in other organism during symbiotic interaction|positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction|activation of killing of cells of another organism|up-regulation of killing of cells of another organism|up regulation of killing of cells of another organism|activation by organism of apoptotic programmed cell death in other organism during symbiotic interaction|positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction https://github.com/geneontology/go-ontology/issues/20287 GO:0052529|GO:0052518|GO:0052330|GO:0052388|GO:0052501 biological_process owl:Class
GO:0043068 biolink:NamedThing positive regulation of programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes. got7fsn_ti activation of programmed cell death|stimulation of programmed cell death|upregulation of programmed cell death|positive regulation of non-apoptotic programmed cell death|up-regulation of programmed cell death|up regulation of programmed cell death GO:0043071 biological_process owl:Class
GO:0006527 biolink:NamedThing arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. got7fsn_ti arginine degradation|arginine catabolism|arginine breakdown biological_process owl:Class
GO:0102530 biolink:NamedThing aclacinomycin T methylesterase activity Catalysis of the reaction: aclacinomycin T(1+) + H2O <=> 15-demethylaclacinomycin T + methanol + H+. got7fsn_ti MetaCyc:RXN-14703|EC:3.1.1.95|RHEA:37891 molecular_function owl:Class
GO:0019422 biolink:NamedThing disproportionation of elemental sulfur The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2. got7fsn_ti disproportionation of elemental sulphur MetaCyc:P203-PWY biological_process owl:Class
GO:0005879 biolink:NamedThing axonemal microtubule A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules. got7fsn_ti cellular_component owl:Class
GO:0018317 biolink:NamedThing protein C-linked glycosylation via tryptophan The glycosylation of a carbon atom of a peptidyl-tryptophan residue. got7fsn_ti protein amino acid C-linked glycosylation via tryptophan biological_process owl:Class
GO:0047668 biolink:NamedThing amygdalin beta-glucosidase activity Catalysis of the reaction: (R)-amygdalin + H(2)O = (R)-prunasin + D-glucose. got7fsn_ti amygdalinase|amygdalin beta-D-glucohydrolase activity|amygdalin b-glucosidase activity|amygdalin hydrolase activity|(R)-amygdalin beta-glucosidase activity|amygdalin glucosidase activity GO:0080080 KEGG_REACTION:R02985|EC:3.2.1.117|MetaCyc:AMYGDALIN-BETA-GLUCOSIDASE-RXN|RHEA:14177 molecular_function owl:Class
GO:0031958 biolink:NamedThing corticosteroid receptor signaling pathway Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor. got7fsn_ti corticosteroid receptor signalling pathway biological_process owl:Class
GO:0102849 biolink:NamedThing 1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-18:3-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8314|EC:1.14.19.35 molecular_function owl:Class
GO:0140462 biolink:NamedThing pericentric heterochromatin organization The organization of chromatin into heterochromatin at the pericentric region of a chromosome. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19396 pg 2020-05-06T07:47:09Z biological_process owl:Class
GO:0034272 biolink:NamedThing phosphatidylinositol 3-kinase complex, class III, type II A class III phosphatidylinositol 3-kinase complex that is involved in vacuolar protein sorting (VPS) via endosomes. In budding yeast, this complex consists of Vps30p, Vps34p, Vps38 and Vps15p. got7fsn_ti PtdIns-3-kinase complex II|phosphatidylinositol 3-kinase complex II Note that this term should not be confused with '1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex; GO:0005943' or '1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex ; GO:0005944'. cellular_component owl:Class
GO:0000838 biolink:NamedThing Hrd1p ubiquitin ligase ERAD-M complex A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. got7fsn_ti cellular_component owl:Class
GO:0001780 biolink:NamedThing neutrophil homeostasis The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. biological_process owl:Class
GO:0031847 biolink:NamedThing type 1 neurotensin receptor binding Binding to a type 1 neurotensin receptor. got7fsn_ti type 1 neurotensin receptor ligand molecular_function owl:Class
GO:0031846 biolink:NamedThing neurotensin receptor binding Binding to a neurotensin receptor. got7fsn_ti neurotensin receptor ligand molecular_function owl:Class
GO:0021845 biolink:NamedThing neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner. got7fsn_ti biological_process owl:Class
GO:0038141 biolink:NamedThing ERBB4-ERBB4 complex A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4). got7fsn_ti ERBB4 homodimer bf 2012-03-30T02:06:20Z cellular_component owl:Class
GO:0018681 biolink:NamedThing deisopropylatrazine monooxygenase activity Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine. got7fsn_ti EC:1.14.15.-|KEGG_REACTION:R05567 molecular_function owl:Class
GO:0103032 biolink:NamedThing tartronate semialdehyde reductase activity Catalysis of the reaction: D-glycerate + NAD <=> H+ + 2-hydroxy-3-oxopropanoate + NADH. got7fsn_ti RHEA:18845|MetaCyc:RXN0-5289 molecular_function owl:Class
GO:0000244 biolink:NamedThing spliceosomal tri-snRNP complex assembly The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex. got7fsn_ti assembly of spliceosomal tri-snRNP|spliceosomal tri-snRNP assembly|spliceosomal tri-snRNP U4atac/U6atac.U5 assembly|assembly of spliceosomal tri-snRNP U4atac/U6atac.U5|spliceosomal tri-snRNP U4/U6.U5 assembly|snRNP recycling|assembly of spliceosomal tri-snRNP U4/U6.U5 GO:0000351|GO:0000355 biological_process owl:Class
GO:0035158 biolink:NamedThing regulation of tube diameter, open tracheal system Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size. got7fsn_ti regulation of tracheal tube diameter|tracheal tube expansion|tracheal tube dilation biological_process owl:Class
GO:0035296 biolink:NamedThing regulation of tube diameter Any process that modulates the diameter of a tube. got7fsn_ti biological_process owl:Class
GO:0051039 biolink:NamedThing positive regulation of transcription involved in meiotic cell cycle Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle. got7fsn_ti positive regulation of meiotic transcription|upregulation of transcription during meiosis|up regulation of transcription during meiosis|up-regulation of transcription during meiosis|activation of transcription during meiosis|stimulation of transcription during meiosis|positive regulation of transcription, meiotic biological_process owl:Class
GO:0019153 biolink:NamedThing protein-disulfide reductase (glutathione) activity Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol. got7fsn_ti protein disulfide reductase (glutathione)|insulin reductase activity|thiol-protein disulphide oxidoreductase activity|glutathione-insulin transhydrogenase activity|glutaredoxin reductase|protein disulfide transhydrogenase activity|protein-disulfide isomerase/oxidoreductase activity|reductase, protein disulfide (glutathione)|protein-disulfide interchange enzyme|glutathione-protein disulfide oxidoreductase activity|protein-disulphide reductase (glutathione) activity|glutathione--insulin transhydrogenase activity|GSH-insulin transhydrogenase activity|glutathione:protein-disulfide oxidoreductase activity|thiol:protein-disulfide oxidoreductase activity EC:1.8.4.2|MetaCyc:PRODISULFREDUCT-RXN|RHEA:21064 molecular_function owl:Class
GO:0046547 biolink:NamedThing trans-aconitate 3-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + trans-aconitate = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine. got7fsn_ti S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 3'-O-methyltransferase activity EC:2.1.1.145|RHEA:22200|MetaCyc:2.1.1.145-RXN|KEGG_REACTION:R05764 molecular_function owl:Class
GO:0102964 biolink:NamedThing S-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity Catalysis of the reaction: (S)-corytuberine + S-adenosyl-L-methionine <=> H+ + magnoflorine + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:51524|MetaCyc:RXN-9315 molecular_function owl:Class
GO:0034625 biolink:NamedThing fatty acid elongation, monounsaturated fatty acid Elongation of a fatty acid chain into which one C-C double bond has been introduced. got7fsn_ti biological_process owl:Class
GO:0016333 biolink:NamedThing morphogenesis of follicular epithelium The process in which the anatomical structures of a follicular epithelium are generated and organized. got7fsn_ti biological_process owl:Class
GO:0050998 biolink:NamedThing nitric-oxide synthase binding Binding to nitric-oxide synthase. got7fsn_ti NOS binding molecular_function owl:Class
GO:0044318 biolink:NamedThing L-aspartate:fumarate oxidoreductase activity Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate. got7fsn_ti This is based on the finding that L-aspartate oxidase (NadB) of E. coli preferentially uses fumarate as the electron acceptor and does so under anaerobic conditions. The same enzyme uses oxygen as the electron acceptor under aerobic conditions. The EC conflates the two reactions in EC:1.4.3.16 (as they are catalyzed by the same enzyme). jl 2010-07-14T01:50:01Z EC:1.4.3.16 molecular_function owl:Class
GO:0004937 biolink:NamedThing alpha1-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. got7fsn_ti alpha1 adrenoceptor molecular_function owl:Class
GO:0061654 biolink:NamedThing NEDD8 conjugating enzyme activity Isoenergetic transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y -> Y-NEDD8 + X, where both the X-NEDD8 and Y-NEDD8 linkages are thioester bonds between the C-terminal amino acid of NEDD8 and a sulfhydryl side group of a cysteine residue. got7fsn_ti E2 dph 2014-11-06T13:27:56Z molecular_function owl:Class
GO:0010275 biolink:NamedThing NAD(P)H dehydrogenase complex assembly The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool. got7fsn_ti NAD(P)H dehydrogenase complex (plastoquinone) assembly biological_process owl:Class
GO:0033415 biolink:NamedThing UGA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UGA codon. got7fsn_ti TGA codon-amino acid adaptor activity Note that in the standard genetic code, TGA is a stop codon (opal) and is not normally read by a tRNA. molecular_function owl:Class
GO:0006430 biolink:NamedThing lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA. got7fsn_ti biological_process owl:Class
GO:0102733 biolink:NamedThing typhasterol C-23 hydroxylase activity Catalysis of the reaction: typhasterol + O2 + a reduced electron acceptor = castasterone + H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-719 molecular_function owl:Class
GO:0033316 biolink:NamedThing meiotic spindle assembly checkpoint signaling A signal transduction process that contributes to a meiotic spindle assembly checkpoint, that delays the metaphase/anaphase transition of a meiotic cell cycle until the spindle is correctly assembled and chromosomes are attached to the spindle. got7fsn_ti signal transduction involved in meiotic spindle assembly checkpoint|meiotic spindle assembly checkpoint https://github.com/geneontology/go-ontology/issues/20935 GO:0072465 biological_process owl:Class
GO:0044779 biolink:NamedThing meiotic spindle checkpoint signaling A signal transduction process that contributes to a cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle. got7fsn_ti intracellular signaling pathway involved in meiotic spindle checkpoint|intracellular signal transduction pathway involved in meiotic spindle checkpoint|intracellular signaling cascade involved in meiotic spindle checkpoint|intracellular signal transduction involved in meiotic spindle checkpoint|meiotic spindle checkpoint https://github.com/geneontology/go-ontology/issues/20935 jl 2013-03-21T14:01:28Z GO:1902398 biological_process owl:Class
GO:0052078 biolink:NamedThing suppression by symbiont of defense-related host MAP kinase-mediated signal transduction pathway Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti downregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|down-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|negative regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction|suppression by organism of defense-related host MAP kinase-mediated signal transduction pathway|inhibition by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|negative regulation by organism of defense-related host MAPK-mediated signal transduction pathway|negative regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|negative regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway|down regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway https://github.com/geneontology/go-ontology/issues/19235 GO:0052275 biological_process owl:Class
GO:0120204 biolink:NamedThing methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2. got7fsn_ti krc 2019-05-10T15:58:47Z molecular_function owl:Class
GO:0061248 biolink:NamedThing mesonephric glomerulus vasculature morphogenesis The process in which the anatomical structures of the mesonephric glomerulus vasculature are generated and organized. The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus. got7fsn_ti dph 2010-08-30T01:11:34Z biological_process owl:Class
GO:0072103 biolink:NamedThing glomerulus vasculature morphogenesis The process in which the anatomical structures of the glomerulus vasculature are generated and organized. The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus. got7fsn_ti mah 2010-02-10T02:34:54Z biological_process owl:Class
GO:0047086 biolink:NamedThing ketosteroid monooxygenase activity Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. got7fsn_ti steroid-ketone monooxygenase activity|progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing)|ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing)|17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving)|androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing) MetaCyc:1.14.13.54-RXN|EC:1.14.13.54 molecular_function owl:Class
GO:0045921 biolink:NamedThing positive regulation of exocytosis Any process that activates or increases the frequency, rate or extent of exocytosis. got7fsn_ti upregulation of exocytosis|activation of exocytosis|stimulation of exocytosis|up-regulation of exocytosis|up regulation of exocytosis biological_process owl:Class
GO:0014820 biolink:NamedThing tonic smooth muscle contraction A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction. got7fsn_ti biological_process owl:Class
GO:0102655 biolink:NamedThing 1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:1-2-trans-16:1-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-1726|EC:1.14.19.23 molecular_function owl:Class
GO:0097385 biolink:NamedThing programmed necrotic cell death in response to starvation A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment). got7fsn_ti necrotic cell death in response to starvation pr 2012-10-22T09:02:18Z biological_process owl:Class
GO:0001842 biolink:NamedThing neural fold formation The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove. got7fsn_ti neural groove formation biological_process owl:Class
GO:0047128 biolink:NamedThing 1,2-dehydroreticulinium reductase (NADPH) activity Catalysis of the reaction: (R)-reticuline + NADP(+) = 1,2-dehydroreticuline + H(+) + NADPH. got7fsn_ti (R)-reticuline:NADP+ oxidoreductase activity|1,2-dehydroreticulinium ion reductase activity MetaCyc:1.5.1.27-RXN|KEGG_REACTION:R04695|EC:1.5.1.27|RHEA:17569 molecular_function owl:Class
GO:0034578 biolink:NamedThing limonene 8-hydratase activity Catalysis of the reaction: limonene + H2O = alpha-terpineol. got7fsn_ti UM-BBD_reactionID:r0916 molecular_function owl:Class
GO:0097683 biolink:NamedThing dinoflagellate apex The anterior most point of a dinoflagellate epicone. got7fsn_ti apex The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. pr 2014-12-18T09:29:51Z cellular_component owl:Class
GO:1990025 biolink:NamedThing F bouton Synaptic bouton found in the ventral horn of the spinal cord. F boutons range in diameter from 0.5 to 7 um and contain flattened or pleomorphic synaptic vesicles. got7fsn_ti pr 2013-02-06T10:29:42Z NIF_Subcellular:nlx_subcell_100206 cellular_component owl:Class
GO:0032301 biolink:NamedThing MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6. got7fsn_ti MMR complex|MSH2/MSH6 complex cellular_component owl:Class
GO:0007524 biolink:NamedThing adult visceral muscle development The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0010201 biolink:NamedThing response to continuous far red light stimulus by the high-irradiance response system Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence. got7fsn_ti biological_process owl:Class
GO:0007543 biolink:NamedThing sex determination, somatic-gonadal interaction The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism. got7fsn_ti sex determination, somatic/gonadal interaction biological_process owl:Class
GO:0050355 biolink:NamedThing triphosphatase activity Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate. got7fsn_ti triphosphate phosphohydrolase activity|tripolyphosphatase activity|inorganic triphosphatase activity RHEA:14157|MetaCyc:TRIPHOSPHATASE-RXN|KEGG_REACTION:R00138|EC:3.6.1.25 molecular_function owl:Class
GO:0043880 biolink:NamedThing crotonyl-CoA reductase activity Catalysis of the reduction of crotonyl-CoA to butyryl-CoA. got7fsn_ti crotonyl-coenzyme A reductase activity|CCR molecular_function owl:Class
GO:0044382 biolink:NamedThing CLRC complex localization to heterochromatin The process by which a CLRC complex is transported to, or maintained in, heterochromatin. CLRC complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation. got7fsn_ti CLRC ubiquitin ligase complex localization to heterochromatin|CLRC ubiquitin ligase complex localisation to heterochromatin jl 2011-12-13T03:37:18Z biological_process owl:Class
GO:0097355 biolink:NamedThing protein localization to heterochromatin Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin. got7fsn_ti protein localisation to heterochromatin pr 2012-07-03T03:19:07Z biological_process owl:Class
GO:0043806 biolink:NamedThing keto acid formate lyase activity Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate. got7fsn_ti keto-acid formate acetyltransferase|keto-acid formate-lyase activity|keto-acid formate lyase activity MetaCyc:KETOBUTFORMLY-RXN|EC:2.3.1.- molecular_function owl:Class
GO:0097302 biolink:NamedThing lipoprotein biosynthetic process via diacylglyceryl transfer The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex. got7fsn_ti lipoprotein biosynthesis (diacylglyceryl transfer) pr 2012-05-15T01:02:02Z biological_process owl:Class
GO:0042158 biolink:NamedThing lipoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. got7fsn_ti lipoprotein formation|lipoprotein synthesis|lipoprotein anabolism|lipoprotein biosynthesis biological_process owl:Class
GO:0050643 biolink:NamedThing 10-deacetylbaccatin III 10-O-acetyltransferase activity Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA. got7fsn_ti acetyl-CoA:taxan-10beta-ol O-acetyltransferase EC:2.3.1.167|RHEA:20137|KEGG_REACTION:R06311|MetaCyc:2.3.1.167-RXN molecular_function owl:Class
GO:0044341 biolink:NamedThing sodium-dependent phosphate transport The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions. got7fsn_ti jl 2010-08-20T04:16:15Z biological_process owl:Class
GO:0006817 biolink:NamedThing phosphate ion transport The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti phosphate transport biological_process owl:Class
GO:1904516 biolink:NamedThing myofibroblast cell apoptotic process Any apoptotic process in a myofibroblast cell. got7fsn_ti myofibroblast cell apoptosis|MFB apoptotic process|MFB apoptosis sl 2015-07-28T18:29:08Z biological_process owl:Class
GO:0120169 biolink:NamedThing detection of cold stimulus involved in thermoception The series of events in which a cold stimulus is received and converted into a molecular signal as part of thermoception. got7fsn_ti sensory transduction of cold stimulus during thermoception|sensory detection of cold stimulus during thermoception|thermoception, sensory detection of cold stimulus|thermoception, sensory transduction of cold stimulus krc 2018-05-21T20:36:05Z biological_process owl:Class
GO:0050960 biolink:NamedThing detection of temperature stimulus involved in thermoception The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception. got7fsn_ti sensory detection of temperature stimulus during thermoception|sensory detection of thermal stimulus during thermoception|sensory transduction of temperature stimulus during thermoception|thermoception, sensory transduction of temperature stimulus|sensory transduction of thermal stimulus during thermoception|thermoception, sensory transduction of thermal stimulus|thermoception, sensory detection of temperature stimulus|thermoception, sensory detection of thermal stimulus biological_process owl:Class
GO:0033620 biolink:NamedThing Mei2 nuclear dot complex A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I. got7fsn_ti Mei2 nuclear dot|Mei2 dot|nuclear body cellular_component owl:Class
GO:0102471 biolink:NamedThing 2-hydroxynaringenin-6C-glucoside dehydratase activity Catalysis of the reaction: 6C-glucosyl-2-hydroxynaringenin <=> isovitexin-7-olate + H2O. got7fsn_ti MetaCyc:RXN-14076 molecular_function owl:Class
GO:0003094 biolink:NamedThing glomerular filtration The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein. got7fsn_ti biological_process owl:Class
GO:0097205 biolink:NamedThing renal filtration A renal system process in which fluid circulating through the body is filtered through a barrier system. got7fsn_ti pr 2012-01-03T03:10:17Z biological_process owl:Class
GO:0033935 biolink:NamedThing oligoxyloglucan beta-glycosidase activity Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic links in oligoxyloglucans so as to remove successive isoprimeverose (i.e. alpha-xylo-1,6-beta-D-glucosyl-) residues from the non-reducing chain ends. got7fsn_ti oligoxyloglucan xyloglucohydrolase activity|oligoxyloglucan hydrolase activity|isoprimeverose-producing oligoxyloglucan hydrolase activity MetaCyc:3.2.1.120-RXN|EC:3.2.1.120 molecular_function owl:Class
GO:0033948 biolink:NamedThing fructan beta-(2,1)-fructosidase activity Catalysis of the hydrolysis of terminal, non-reducing (2->1) linked beta-D-fructofuranose residues in fructans. got7fsn_ti beta-(2,1)-D-fructan fructohydrolase activity|beta-(2,1)-fructan exohydrolase activity|1-FEH II|1-fructan exohydrolase activity|beta-(2,1)-linkage-specific fructan-beta-fructosidase activity|1-FEH w1|1-FEH w2 MetaCyc:3.2.1.153-RXN|EC:3.2.1.153 molecular_function owl:Class
GO:0102029 biolink:NamedThing D-lactate dehydrogenase (quinone) activity Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol. got7fsn_ti RHEA:51468|MetaCyc:DLACTDEHYDROGFAD-RXN|EC:1.1.5.12 molecular_function owl:Class
GO:0010972 biolink:NamedThing negative regulation of G2/M transition of mitotic cell cycle Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. got7fsn_ti negative regulation of mitotic entry tb 2009-06-01T10:18:29Z biological_process owl:Class
GO:0102673 biolink:NamedThing fatty aldehyde dehydrogenase activity Catalysis of the reaction: NAD(1-) + H2O + a fatty aldehyde <=> NADH(2-) + 2 H+ + a fatty acid. got7fsn_ti MetaCyc:RXN-4142 molecular_function owl:Class
GO:0018774 biolink:NamedThing 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate. got7fsn_ti 2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity|HOHPDA hydrolase activity|2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity EC:3.7.1.8|MetaCyc:3.7.1.8-RXN|UM-BBD_enzymeID:e0033|RHEA:17161 molecular_function owl:Class
GO:0061599 biolink:NamedThing molybdopterin molybdotransferase activity Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP. got7fsn_ti dph 2014-02-10T14:30:31Z EC:2.10.1.1|Reactome:R-HSA-947531|RHEA:35047 molecular_function owl:Class
GO:0036292 biolink:NamedThing DNA rewinding The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA. got7fsn_ti single-stranded DNA bubble rewinding|DNA annealing|RPA-dependent DNA rewinding bf 2012-07-18T10:43:41Z biological_process owl:Class
GO:0055094 biolink:NamedThing response to lipoprotein particle Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. got7fsn_ti response to lipoprotein particle stimulus biological_process owl:Class
GO:0048496 biolink:NamedThing maintenance of animal organ identity The process in which the identity of an animal organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0015516 biolink:NamedThing tartrate:succinate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out). got7fsn_ti molecular_function owl:Class
GO:0015554 biolink:NamedThing tartrate transmembrane transporter activity Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria. got7fsn_ti molecular_function owl:Class
GO:0033985 biolink:NamedThing acidocalcisome lumen The volume enclosed by the membranes of an acidocalcisome. got7fsn_ti cellular_component owl:Class
GO:0019155 biolink:NamedThing 3-(imidazol-5-yl)lactate dehydrogenase activity Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+. got7fsn_ti imidazol-5-yl lactate dehydrogenase activity|(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity MetaCyc:IMILACTDEHYDROG-RXN|EC:1.1.1.111 molecular_function owl:Class
GO:0047751 biolink:NamedThing cholestenone 5-alpha-reductase activity Catalysis of the reaction: 5alpha-cholestan-3-one + NADP(+) = cholest-4-en-3-one + H(+) + NADPH. got7fsn_ti 3-oxosteroid delta4-dehydrogenase|testosterone 5alpha-reductase|3-oxo-5alpha-steroid:NADP+ delta4-oxidoreductase activity|steroid 5alpha-reductase|testosterone delta4-hydrogenase activity|delta4-3-ketosteroid 5alpha-oxidoreductase activity|cholestenone 5alpha-reductase activity|3-oxosteroid 5alpha-reductase activity|4-ene-3-oxosteroid 5alpha-reductase activity|5alpha-reductase|testosterone delta4-5alpha-reductase activity|reduced nicotinamide adenine dinucleotide phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase activity|steroid 5alpha-hydrogenase activity|4-ene-5alpha-reductase activity|cholestenone 5a-reductase activity|cholest-4-en-3-one 5alpha-reductase activity MetaCyc:CHOLESTENONE-5-ALPHA-REDUCTASE-RXN|KEGG_REACTION:R02610|EC:1.3.1.22|RHEA:24552 molecular_function owl:Class
GO:0035456 biolink:NamedThing response to interferon-beta Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon. got7fsn_ti response to fibroblast interferon|response to fiblaferon|response to interferon beta|response to beta-1 interferon bf 2010-04-16T11:06:12Z biological_process owl:Class
GO:0019536 biolink:NamedThing vibriobactin metabolic process The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae. got7fsn_ti vibriobactin metabolism biological_process owl:Class
GO:0009524 biolink:NamedThing phragmoplast Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules. got7fsn_ti Wikipedia:Phragmoplast cellular_component owl:Class
GO:0098030 biolink:NamedThing icosahedral viral capsid, neck A region of constriction located below the head and above the tail sheath of viruses with contractile tails (Myoviridae). got7fsn_ti bm 2012-07-19T14:56:28Z cellular_component owl:Class
GO:0097677 biolink:NamedThing STAT family protein binding Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses. got7fsn_ti signal transducers and activators of transcription family protein binding pr 2014-11-04T11:31:03Z molecular_function owl:Class
GO:0032115 biolink:NamedThing sorbose reductase activity Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction. got7fsn_ti D-glucitol:NADP+ oxidoreductase activity|Sou1p KEGG_REACTION:R07346|RHEA:14609|MetaCyc:1.1.1.289-RXN|EC:1.1.1.289 molecular_function owl:Class
GO:0070523 biolink:NamedThing 11-beta-hydroxysteroid dehydrogenase (NAD+) activity Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21915 Wikipedia:11beta-hydroxysteroid_dehydrogenase|RHEA:53116 molecular_function owl:Class
GO:0044873 biolink:NamedThing lipoprotein localization to membrane A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane. got7fsn_ti jl 2014-11-25T16:28:43Z biological_process owl:Class
GO:0044872 biolink:NamedThing lipoprotein localization Any process in which a lipoprotein is transported to, or maintained in, a specific location. got7fsn_ti jl 2014-11-25T16:27:06Z biological_process owl:Class
GO:0018457 biolink:NamedThing perillyl-alcohol dehydrogenase activity Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde. got7fsn_ti perillyl alcohol dehydrogenase activity|perillyl-alcohol:NAD+ oxidoreductase activity EC:1.1.1.144|UM-BBD_reactionID:r0729|RHEA:10664|MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN|KEGG_REACTION:R03945 molecular_function owl:Class
GO:0018777 biolink:NamedThing 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol). got7fsn_ti molecular_function owl:Class
GO:1990525 biolink:NamedThing BIR domain binding Binding to a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain. got7fsn_ti Baculovirus Inhibitor of apoptosis protein Repeat domain binding An example of this is the Drosophila reaper gene in PMID:21886178. jl 2014-11-04T12:36:56Z molecular_function owl:Class
GO:0062148 biolink:NamedThing L-gamma-glutamyl-L-propargylglycine hydroxylase activity Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate. got7fsn_ti dph 2019-09-02T17:04:43Z RHEA:59900 molecular_function owl:Class
GO:0048356 biolink:NamedThing root epithelial mucilage biosynthetic process The chemical reactions and pathways resulting in the formation of mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth. got7fsn_ti root epithelial mucilage formation|root epithelial mucilage biosynthesis|root epithelial mucilage synthesis|root epithelial mucilage anabolism biological_process owl:Class
GO:0000326 biolink:NamedThing protein storage vacuole A storage vacuole that contains a lytic vacuole; identified in plants. got7fsn_ti cellular_component owl:Class
GO:0061781 biolink:NamedThing mitotic cohesin unloading Negative regulation of sister chromatid cohesion by the topological unlinking of a cohesin ring to DNA as part of the mitotic cell cycle. got7fsn_ti dph 2016-08-24T09:43:07Z biological_process owl:Class
GO:0042554 biolink:NamedThing superoxide anion generation The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. got7fsn_ti superoxide release biological_process owl:Class
GO:0006801 biolink:NamedThing superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. got7fsn_ti superoxide free radical metabolic process|oxygen free radical metabolic process|superoxide free radical metabolism|oxygen free radical metabolism|superoxide metabolism biological_process owl:Class
GO:0102033 biolink:NamedThing long-chain fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl-long-chain fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy-long-chain fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti cytochrome P450 fatty acid omega-hydroxylase activity https://github.com/geneontology/go-ontology/issues/14194|https://github.com/geneontology/go-ontology/issues/19899 EC:1.14.14.80|RHEA:56748|MetaCyc:RXN-16394 molecular_function owl:Class
GO:0120250 biolink:NamedThing fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19899 krc 2020-09-01T00:19:13Z RHEA:39023 molecular_function owl:Class
GO:0035925 biolink:NamedThing mRNA 3'-UTR AU-rich region binding Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. got7fsn_ti mRNA 3'-UTR adenylate/uridylate-rich element binding|AU-rich element binding|adenylate/uridylate-rich element binding|ARE binding https://github.com/geneontology/go-ontology/issues/16842 bf 2011-07-19T09:30:18Z GO:0017091 molecular_function owl:Class
GO:0102154 biolink:NamedThing 8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 8C-glucosyl-2-hydroxynaringenin + UDP + 2 H+. got7fsn_ti MetaCyc:RXN-11685 molecular_function owl:Class
GO:0043061 biolink:NamedThing meiotic metaphase II plate congression The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II. got7fsn_ti biological_process owl:Class
GO:0075271 biolink:NamedThing zygosporangium development The process in which a fruiting body called zygosporangium is formed. A zygosporangium is a thick-walled structure in which spores are produced, and is characteristic of the Zygomycetes. got7fsn_ti biological_process owl:Class
GO:0061254 biolink:NamedThing mesonephric glomerular parietal epithelial cell development The process whose specific outcome is the progression of a mesonephric glomerular parietal epithelial cell over time, from its formation to the mature structure. Mesonephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. got7fsn_ti dph 2010-08-30T01:30:36Z biological_process owl:Class
GO:0072016 biolink:NamedThing glomerular parietal epithelial cell development The process whose specific outcome is the progression of a glomerular parietal epithelial cell over time, from its formation to the mature structure. Glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. got7fsn_ti Bowman's capsule development mah 2010-01-25T02:13:16Z biological_process owl:Class
GO:0035478 biolink:NamedThing chylomicron binding Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. got7fsn_ti bf 2010-04-23T10:18:52Z molecular_function owl:Class
GO:0061038 biolink:NamedThing uterus morphogenesis The process in which anatomical structures of the uterus are generated and organized. got7fsn_ti dph 2010-02-22T11:12:35Z biological_process owl:Class
GO:0038104 biolink:NamedThing nodal receptor complex A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell. got7fsn_ti ActRIIB.ALK4.EGF-CFC complex Nodal signals through activin receptors but (unlike activin) also requires EGF-CFC coreceptors (such as Cripto or Cryptic in mammals) to signal. This term is intended for receptor/co-receptor components and not a nodal-receptor complex. bf 2012-02-17T11:12:21Z cellular_component owl:Class
GO:0045282 biolink:NamedThing plasma membrane succinate dehydrogenase complex A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species. got7fsn_ti succinate dehydrogenase complex cellular_component owl:Class
GO:0062031 biolink:NamedThing filamentous growth MAPK cascade The MAPK cascade which is activated as a result of partial nutrient deprivation and which results in filamentous growth. got7fsn_ti dph 2018-04-17T15:18:44Z biological_process owl:Class
GO:0046895 biolink:NamedThing N-terminal peptidyl-isoleucine methylation The methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine. got7fsn_ti RESID:AA0336 biological_process owl:Class
GO:0031412 biolink:NamedThing gas vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. got7fsn_ti gas vesicle organization and biogenesis|gas vesicle formation|gas vesicle biosynthesis|gas vesicle organisation Note that although gas vesicles are commonly referred to as 'vesicles' or 'vacuoles' in the literature, they are not surrounded by a membrane. biological_process owl:Class
GO:0008753 biolink:NamedThing NADPH dehydrogenase (quinone) activity Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol. got7fsn_ti reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase|NADPH oxidase|NADPH:(quinone-acceptor) oxidoreductase EC:1.6.5.10|KEGG_REACTION:R07359|MetaCyc:NADPH-DEHYDROGENASE-QUINONE-RXN|RHEA:46164 molecular_function owl:Class
GO:0003955 biolink:NamedThing NAD(P)H dehydrogenase (quinone) activity Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone. got7fsn_ti vitamin-K reductase activity|diaphorase activity|p-benzoquinone reductase activity|reduced NAD(P)H dehydrogenase activity|NAD(P)H:(quinone-acceptor)oxidoreductase activity|Naphthoquinone reductase activity|NAD(P)H(2) dehydrogenase (quinone) activity|azoreductase activity|QR1|naphthoquinone reductase activity|NAD(P)H menadione reductase activity|quinone reductase activity|NQO1|NAD(P)H2 dehydrogenase (quinone)|flavoprotein NAD(P)H-quinone reductase activity|dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity|NAD(P)H-quinone oxidoreductase activity|reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity|viologen accepting pyridine nucleotide oxidoreductase activity|menadione reductase activity|NAD(P)H: menadione oxidoreductase activity|NAD(P)H-quinone dehydrogenase activity|phylloquinone reductase activity|NADH-menadione reductase activity|DT-diaphorase activity|menadione oxidoreductase activity|NAD(P)H:quinone oxidoreductase activity|NAD(P)H dehydrogenase activity|vitamin K reductase activity EC:1.6.5.2|MetaCyc:NQOR-RXN|UM-BBD_reactionID:r0227 molecular_function owl:Class
GO:0018139 biolink:NamedThing peptide cross-linking via L-phenylalanine thiazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti RESID:AA0243 biological_process owl:Class
GO:0035328 biolink:NamedThing transcriptionally silent chromatin The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed. got7fsn_ti transcriptionally inactive chromatin bf 2010-02-26T10:24:13Z cellular_component owl:Class
GO:0035868 biolink:NamedThing alphav-beta3 integrin-HMGB1 complex A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein. got7fsn_ti alphav-beta3 integrin-high mobility group box 1 complex|alphaV-beta3 integrin-HMGB1 complex bf 2011-05-25T03:07:24Z cellular_component owl:Class
GO:1990810 biolink:NamedThing microtubule anchoring at mitotic spindle pole body Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end. got7fsn_ti vw 2015-07-24T12:52:25Z biological_process owl:Class
GO:0071622 biolink:NamedThing regulation of granulocyte chemotaxis Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus. got7fsn_ti mah 2010-02-09T04:09:24Z biological_process owl:Class
GO:0018097 biolink:NamedThing protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine. got7fsn_ti protein amino acid cinnamylation RESID:AA0207 biological_process owl:Class
GO:0106004 biolink:NamedThing tRNA (guanine-N7)-methylation The process whereby a guanine in a tRNA is methylated at the N7 position of guanine. got7fsn_ti hjd 2017-04-07T18:17:38Z biological_process owl:Class
GO:0050513 biolink:NamedThing glycoprotein 2-beta-D-xylosyltransferase activity Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H(+) + UDP. got7fsn_ti glycoprotein 2-b-D-xylosyltransferase activity|beta-1,2-xylosyltransferase activity|1,2-beta-xylosyltransferase activity EC:2.4.2.38|KEGG_REACTION:R06016|MetaCyc:2.4.2.38-RXN|RHEA:10612 molecular_function owl:Class
GO:0047285 biolink:NamedThing flavonol-3-O-glycoside xylosyltransferase activity Catalysis of the reaction: flavonol 3-O-glycoside + UDP-D-xylose = flavonol 3-O-D-xylosylglycoside + UDP. got7fsn_ti UDP-D-xylose:flavonol-3-O-glycoside 2''-O-beta-D-xylosyltransferase activity EC:2.4.2.35|RHEA:19701|MetaCyc:2.4.2.35-RXN molecular_function owl:Class
GO:0008714 biolink:NamedThing AMP nucleosidase activity Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine. got7fsn_ti AMP phosphoribohydrolase activity|adenylate nucleosidase activity|adenosine monophosphate nucleosidase activity EC:3.2.2.4|RHEA:20129|MetaCyc:AMP-NUCLEOSID-RXN|KEGG_REACTION:R00182 molecular_function owl:Class
GO:0035321 biolink:NamedThing maintenance of imaginal disc-derived wing hair orientation Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity. got7fsn_ti maintenance of wing hair orientation biological_process owl:Class
GO:0021541 biolink:NamedThing ammon gyrus development The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons. got7fsn_ti cornu ammonis development|Ammon's horn development biological_process owl:Class
GO:0008414 biolink:NamedThing CDP-alcohol phosphotransferase activity Catalysis of the transfer of a CDP-alcohol group from one compound to another. got7fsn_ti molecular_function owl:Class
GO:0070027 biolink:NamedThing carbon monoxide sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of carbon monoxide (CO). got7fsn_ti molecular_function owl:Class
GO:0070025 biolink:NamedThing carbon monoxide binding Binding to carbon monoxide (CO). got7fsn_ti CO binding molecular_function owl:Class
GO:0101026 biolink:NamedThing mitotic nuclear membrane biogenesis A process in which the nuclear inner or outer membrane is synthesized, aggregates, and bonds together during mitotic nuclear division. got7fsn_ti nuclear membrane biogenesis involved in mitotic nuclear division biological_process owl:Class
GO:0101025 biolink:NamedThing nuclear membrane biogenesis The process in which a nuclear membrane is synthesized, aggregates, and bonds together. got7fsn_ti biological_process owl:Class
GO:0048264 biolink:NamedThing determination of ventral identity The regionalization process that results in the determination of the identity of part of an organism or organ where those parts are of the type that occur in the ventral region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti determination of abaxial identity biological_process owl:Class
GO:0045824 biolink:NamedThing negative regulation of innate immune response Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. got7fsn_ti downregulation of innate immune response|inhibition of innate immune response|down-regulation of innate immune response|down regulation of innate immune response biological_process owl:Class
GO:1990760 biolink:NamedThing osmolarity-sensing cation channel activity Enables the transmembrane transfer of a cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides. got7fsn_ti sl 2015-06-05T21:58:50Z molecular_function owl:Class
GO:1990973 biolink:NamedThing transmembrane actin-associated (TAN) line A linear array of nuclear envelope membrane proteins composed of nesprin-2G and SUN2, which couple the nucleus to moving actin cables, resulting in rearward nuclear transport (away from the leading edge). got7fsn_ti TAN line hjd 2016-06-22T15:05:09Z cellular_component owl:Class
GO:0001827 biolink:NamedThing inner cell mass cell fate commitment The cell fate commitment of precursor cells that will become inner cell mass cells. got7fsn_ti See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'. biological_process owl:Class
GO:0097204 biolink:NamedThing phagocytic cup base The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking. got7fsn_ti pr 2011-12-21T10:29:07Z cellular_component owl:Class
GO:0046892 biolink:NamedThing peptidyl-S-carbamoyl-L-cysteine dehydration The dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine. got7fsn_ti formation of peptidyl-S-cyanocysteine|formation of peptidyl-serine thiocyanate ester RESID:AA0333 biological_process owl:Class
GO:0019841 biolink:NamedThing retinol binding Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. got7fsn_ti vitamin A1 alcohol binding|vitamin A1 binding molecular_function owl:Class
GO:0004895 biolink:NamedThing cell adhesion receptor activity The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins. got7fsn_ti https://github.com/geneontology/go-ontology/issues/15237 Reinstated term from obsolete. molecular_function owl:Class
GO:0050499 biolink:NamedThing oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H. got7fsn_ti EC:1.20.1.- molecular_function owl:Class
GO:0009094 biolink:NamedThing L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. got7fsn_ti phenylalanine biosynthetic process, prephenate pathway|L-phenylalanine biosynthesis|L-phenylalanine anabolism|phenylalanine biosynthesis|phenylalanine biosynthetic process|phenylalanine biosynthetic process, shikimate pathway|L-phenylalanine formation|L-phenylalanine synthesis GO:0019274|GO:0019275 biological_process owl:Class
GO:0106154 biolink:NamedThing perithecium formation The process of producing flask-shaped fruiting bodies, called perithecia. In the ascomycetous fungi such as Neurospora crassa and Sordaria macrospora, these perithecia are formed in the sexual phase and they discharge ascospores through the ostiolum at the tip of the perithecial neck. got7fsn_ti hjd 2018-09-19T19:12:53Z biological_process owl:Class
GO:0035698 biolink:NamedThing CD8-positive, alpha-beta cytotoxic T cell extravasation The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue. got7fsn_ti bf 2011-02-28T03:09:53Z biological_process owl:Class
GO:0036168 biolink:NamedThing filamentous growth of a population of unicellular organisms in response to heat The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature. got7fsn_ti bf 2012-03-27T03:53:28Z biological_process owl:Class
GO:0110013 biolink:NamedThing positive regulation of aggregation involved in sorocarp development Any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. got7fsn_ti kmv 2017-05-10T12:52:46Z biological_process owl:Class
GO:0097025 biolink:NamedThing MPP7-DLG1-LIN7 complex A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions. got7fsn_ti pr 2011-03-30T05:03:33Z cellular_component owl:Class
GO:0033186 biolink:NamedThing CAF-1 complex A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48. got7fsn_ti chromatin assembly factor 1 complex In yeast the subunits are MSI1/p50, CAC2/p60 and CAC1/p90. cellular_component owl:Class
GO:0007303 biolink:NamedThing cytoplasmic transport, nurse cell to oocyte The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte. got7fsn_ti biological_process owl:Class
GO:0019430 biolink:NamedThing removal of superoxide radicals Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). got7fsn_ti removal of oxygen free radicals|removal of O2-|cellular detoxification of superoxide radicals MetaCyc:DETOX1-PWY biological_process owl:Class
GO:0061161 biolink:NamedThing positive regulation of establishment of bipolar cell polarity regulating cell shape Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity that regulates the shape of a cell. got7fsn_ti dph 2010-06-23T09:26:45Z biological_process owl:Class
GO:0061173 biolink:NamedThing positive regulation of establishment of bipolar cell polarity Any process that increases the rate, frequency or extent of the establishment of bipolar cell polarity. got7fsn_ti dph 2010-06-30T08:59:20Z biological_process owl:Class
GO:0044350 biolink:NamedThing micropinocytosis An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm. got7fsn_ti single-organism micropinocytosis|clathrin-independent pinocytosis jl 2013-12-02T14:26:30Z GO:1902540 biological_process owl:Class
GO:0006907 biolink:NamedThing pinocytosis An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane. got7fsn_ti fluid-phase endocytosis|clathrin-independent pinocytosis|single-organism pinocytosis jl 2013-12-02T14:14:38Z GO:0006908|GO:1902536 Wikipedia:Pinocytosis biological_process owl:Class
GO:0047722 biolink:NamedThing indolelactate dehydrogenase (NADH) activity Catalysis of the reaction: 3-(indol-3-yl)lactate + NAD(+) = 3-(indol-3-yl)pyruvate + H(+) + NADH. got7fsn_ti indole-3-lactate dehydrogenase activity|(indol-3-yl)lactate:NAD+ oxidoreductase activity|indolelactate:NAD+ oxidoreductase activity KEGG_REACTION:R01971|EC:1.1.1.110|MetaCyc:INDOLELACTATE-DEHYDROGENASE-RXN|RHEA:20133 molecular_function owl:Class
GO:0034237 biolink:NamedThing protein kinase A regulatory subunit binding Binding to one or both of the regulatory subunits of protein kinase A. got7fsn_ti protein kinase A anchoring activity|PKA regulatory subunit binding molecular_function owl:Class
GO:0031842 biolink:NamedThing type 1 neuropeptide Y receptor binding Binding to a type 1 neuropeptide Y receptor. got7fsn_ti type 1 neuropeptide Y receptor ligand molecular_function owl:Class
GO:0051658 biolink:NamedThing maintenance of nucleus location Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of cell nucleus location|maintenance of nucleus localization biological_process owl:Class
GO:0010854 biolink:NamedThing adenylate cyclase regulator activity Binds to and modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. got7fsn_ti molecular_function owl:Class
GO:0035213 biolink:NamedThing clypeo-labral disc development The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite. got7fsn_ti development of structures derived from the clypeo-labral disc biological_process owl:Class
GO:0046947 biolink:NamedThing hydroxylysine biosynthetic process The chemical reactions and pathways resulting in the formation of hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. got7fsn_ti hydroxylysine anabolism|hydroxylysine biosynthesis|hydroxylysine formation|hydroxylysine synthesis biological_process owl:Class
GO:0102453 biolink:NamedThing anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity Catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside]. got7fsn_ti RHEA:35411|MetaCyc:RXN-13959|EC:2.3.1.215 molecular_function owl:Class
GO:0009206 biolink:NamedThing purine ribonucleoside triphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar. got7fsn_ti purine ribonucleoside triphosphate biosynthesis|purine ribonucleoside triphosphate synthesis|purine ribonucleoside triphosphate formation|purine ribonucleoside triphosphate anabolism biological_process owl:Class
GO:0040032 biolink:NamedThing post-embryonic body morphogenesis The process in which the anatomical structures of the post-embryonic soma are generated and organized. got7fsn_ti Note that this term was 'body morphogenesis (sensu Nematoda)'. biological_process owl:Class
GO:0033845 biolink:NamedThing hydroxymethylfurfural reductase (NADPH) activity Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+. got7fsn_ti molecular_function owl:Class
GO:0002196 biolink:NamedThing Ser-tRNA(Ala) hydrolase activity Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala). got7fsn_ti hjd 2011-09-30T02:18:50Z molecular_function owl:Class
GO:0044750 biolink:NamedThing high-affinity nickel cation transmembrane transporter activity Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti jl 2012-11-20T15:15:59Z molecular_function owl:Class
GO:0015099 biolink:NamedThing nickel cation transmembrane transporter activity Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. got7fsn_ti zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity RHEA:29831 molecular_function owl:Class
GO:0045089 biolink:NamedThing positive regulation of innate immune response Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. got7fsn_ti stimulation of innate immune response|up-regulation of innate immune response|up regulation of innate immune response|upregulation of innate immune response biological_process owl:Class
GO:0106034 biolink:NamedThing protein maturation by [2Fe-2S] cluster transfer The transfer of an assembled [2Fe-2S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein. got7fsn_ti hjd 2017-07-07T17:24:59Z biological_process owl:Class
GO:0071799 biolink:NamedThing cellular response to prostaglandin D stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. got7fsn_ti mah 2010-09-03T10:48:35Z biological_process owl:Class
GO:0015052 biolink:NamedThing beta3-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. got7fsn_ti beta3 adrenoceptor molecular_function owl:Class
GO:0004939 biolink:NamedThing beta-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. got7fsn_ti beta adrenoceptor molecular_function owl:Class
GO:0006847 biolink:NamedThing plasma membrane acetate transport The directed movement of acetate across a plasma membrane. got7fsn_ti biological_process owl:Class
GO:0035433 biolink:NamedThing acetate transmembrane transport The process in which acetate is transported across a membrane. Acetate is the 2-carbon carboxylic acid ethanoic acid. got7fsn_ti acetate membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-08T10:59:01Z biological_process owl:Class
GO:0009150 biolink:NamedThing purine ribonucleotide metabolic process The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti purine ribonucleotide metabolism biological_process owl:Class
GO:0047850 biolink:NamedThing diaminopimelate dehydrogenase activity Catalysis of the reaction: meso-2,6-diaminopimelate + H(2)O + NADP(+) = L-2-amino-6-oxopimelate + H(+) + NADPH + NH(4)(+). got7fsn_ti meso-alpha,epsilon-diaminopimelate dehydrogenase activity|meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)|meso-diaminopimelate dehydrogenase activity|meso-diaminopimelate D-dehydrogenase activity EC:1.4.1.16|RHEA:13561|MetaCyc:DIAMINOPIMELATE-DEHYDROGENASE-RXN|KEGG_REACTION:R02755 molecular_function owl:Class
GO:0045197 biolink:NamedThing establishment or maintenance of epithelial cell apical/basal polarity Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. got7fsn_ti biological_process owl:Class
GO:0098838 biolink:NamedThing folate transmembrane transport The process in which a folic acid, or one of its derivatives (dihydrofolate, tetrahydrofolate, methylene-tetrahydrofolate or methyl-tetrahydrofolate) is transported across a membrane. got7fsn_ti folic acid transmembrane transport|reduced folate transmembrane transport https://github.com/geneontology/go-ontology/issues/15461 biological_process owl:Class
GO:0035461 biolink:NamedThing vitamin transmembrane transport The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti vitamin membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-19T10:21:41Z biological_process owl:Class
GO:0086028 biolink:NamedThing bundle of His cell to Purkinje myocyte signaling Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte. got7fsn_ti bundle of His cardiac muscle cell to Purkinje myocyte signaling|bundle of His cardiac muscle cell to Purkinje myocyte signalling tb 2011-11-11T02:02:14Z biological_process owl:Class
GO:0061770 biolink:NamedThing translation elongation factor binding Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation. got7fsn_ti dph 2016-07-09T09:31:11Z molecular_function owl:Class
GO:0033204 biolink:NamedThing ribonuclease P RNA binding Binding to RNA subunit of ribonuclease P. got7fsn_ti RNase P RNA binding molecular_function owl:Class
GO:0001860 biolink:NamedThing complement component C3d receptor activity Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0046356 biolink:NamedThing acetyl-CoA catabolic process The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated. got7fsn_ti acetyl-CoA catabolism|acetyl-CoA breakdown|acetyl-CoA degradation biological_process owl:Class
GO:0099081 biolink:NamedThing supramolecular polymer A polymeric supramolecular structure. got7fsn_ti cellular_component owl:Class
GO:0021653 biolink:NamedThing rhombomere 1 structural organization The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 1 structural organisation biological_process owl:Class
GO:0030284 biolink:NamedThing estrogen receptor activity Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function. got7fsn_ti For estrogen receptors that function within the nucleus to modulate transcription, consider instead annotating to the child terms 'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038052' or 'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038053'. molecular_function owl:Class
GO:0030858 biolink:NamedThing positive regulation of epithelial cell differentiation Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation. got7fsn_ti stimulation of epithelial cell differentiation|activation of epithelial cell differentiation|up-regulation of epithelial cell differentiation|upregulation of epithelial cell differentiation|up regulation of epithelial cell differentiation biological_process owl:Class
GO:0047829 biolink:NamedThing D-nopaline dehydrogenase activity Catalysis of the reaction: N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH. got7fsn_ti nopaline synthase activity|NOS activity|N2-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)|D-nopaline synthase activity|2-N-(D-1,3-dicarboxypropyl)-L-arginine:NADP+ oxidoreductase (L-arginine-forming)|nopaline dehydrogenase activity EC:1.5.1.19|RHEA:19637|MetaCyc:D-NOPALINE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0070287 biolink:NamedThing ferritin receptor activity Combining with ferritin, and delivering ferritin into the cell via endocytosis. got7fsn_ti ferritin complex receptor activity molecular_function owl:Class
GO:1990917 biolink:NamedThing ooplasm The cytoplasm of an ovum. got7fsn_ti sl 2015-12-10T21:40:16Z cellular_component owl:Class
GO:0097656 biolink:NamedThing cell-cell self recognition A cell-cell recognition process by which a cell distinguishes between self and non self during cooperative behavior, such as early development. got7fsn_ti self recognition|kin discrimination|kin recognition Examples are the membrane proteins TgrB1 and TgrC1 in the social amoeba Dictyostelium discoideum. pr 2014-09-24T20:58:35Z biological_process owl:Class
GO:0061613 biolink:NamedThing glycolytic process from glycerol The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH. got7fsn_ti dph 2014-04-04T08:26:57Z biological_process owl:Class
GO:0047217 biolink:NamedThing sucrose-1,6-alpha-glucan 3(6)-alpha-glucosyltransferase activity Catalysis of the reaction: sucrose + 1,6-alpha-D-glucosyl(n) = 1,6-alpha-D-glucosyl(n+1) + fructose. got7fsn_ti water-soluble-glucan synthase activity|GTF-S|sucrose:1,6-alpha-D-glucan 3(6)-alpha-D-glucosyltransferase activity|sucrose:1,6-, 1,3-alpha-D-glucan 3-alpha- and 6-alpha-D-glucosyltransferase|sucrose:1,6-alpha-D-glucan 3-alpha- and 6-alpha-glucosyltransferase activity MetaCyc:2.4.1.125-RXN|EC:2.4.1.125 molecular_function owl:Class
GO:0045505 biolink:NamedThing dynein intermediate chain binding Binding to an intermediate chain of the dynein complex. got7fsn_ti molecular_function owl:Class
GO:0051756 biolink:NamedThing meiotic sister chromatid centromere separation The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis. got7fsn_ti biological_process owl:Class
GO:0051552 biolink:NamedThing flavone metabolic process The chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). got7fsn_ti 2-phenylchromone metabolic process|flavone metabolism|2-phenyl-4H-1-benzopyran-4-one metabolic process|2-phenyl-4H-1-benzopyran-4-one metabolism|2-phenylchromone metabolism biological_process owl:Class
GO:0102233 biolink:NamedThing crotonaldehyde redutase activity Catalysis of the reaction: (cis)-crotonaldehyde + NADPH + H+ <=> butanal + NADP. got7fsn_ti MetaCyc:RXN-12292 molecular_function owl:Class
GO:0010917 biolink:NamedThing negative regulation of mitochondrial membrane potential Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti reduction of mitochondrial membrane potential biological_process owl:Class
GO:0045837 biolink:NamedThing negative regulation of membrane potential Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti downregulation of membrane potential|down regulation of membrane potential|down-regulation of membrane potential|inhibition of membrane potential|reduction of membrane potential biological_process owl:Class
GO:0061544 biolink:NamedThing peptide secretion, neurotransmission The controlled release of a peptide from a cell in which the peptide acts as a neurotransmitter. got7fsn_ti dph 2013-06-25T09:10:10Z biological_process owl:Class
GO:1990168 biolink:NamedThing protein K33-linked deubiquitination A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein. got7fsn_ti sp 2013-08-14T11:19:39Z biological_process owl:Class
GO:0061320 biolink:NamedThing pericardial nephrocyte differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a pericardial nephrocyte. A pericardial nephrocyte is an insect renal cell that filters hemolymph and is found with other pericardial nephrocytes in two rows flanking the dorsal vessel. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. got7fsn_ti pericardial cell differentiation dph 2010-09-24T12:25:53Z GO:0007513 biological_process owl:Class
GO:0034785 biolink:NamedThing salicylate 5-hydroxylase activity Catalysis of the reaction: salicylate + O2 + NAD(P)H + H+ = gentisate + H2O + NAD(P)+. got7fsn_ti UM-BBD_reactionID:r1034|RHEA:35307|EC:1.14.13.172|MetaCyc:RXN-10446 molecular_function owl:Class
GO:0061981 biolink:NamedThing 3-hydroxykynureninase activity Catalysis of the reaction: L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. got7fsn_ti dph 2018-02-14T16:12:49Z RHEA:25143 molecular_function owl:Class
GO:0018465 biolink:NamedThing vanillyl-alcohol oxidase activity Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin. got7fsn_ti 4-hydroxy-2-methoxybenzyl alcohol oxidase activity|vanillyl alcohol:oxygen oxidoreductase activity RHEA:10036|KEGG_REACTION:R02877|MetaCyc:1.1.3.38-RXN|EC:1.1.3.38|UM-BBD_reactionID:r0651 molecular_function owl:Class
GO:0070776 biolink:NamedThing MOZ/MORF histone acetyltransferase complex A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. got7fsn_ti mah 2009-07-02T12:06:04Z cellular_component owl:Class
GO:0050127 biolink:NamedThing N-carbamoylsarcosine amidase activity Catalysis of the reaction: N-carbamoylsarcosine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + sarcosine. got7fsn_ti CSHase activity|N-carbamoylsarcosine amidohydrolase activity|carbamoylsarcosine amidase activity KEGG_REACTION:R01563|RHEA:20057|EC:3.5.1.59|MetaCyc:N-CARBAMOYLSARCOSINE-AMIDASE-RXN molecular_function owl:Class
GO:0001896 biolink:NamedThing autolysis A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation. got7fsn_ti Wikipedia:Autolysis biological_process owl:Class
GO:0042423 biolink:NamedThing catecholamine biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. got7fsn_ti catecholamine biosynthesis|catecholamine formation|catecholamine anabolism|catecholamine synthesis Wikipedia:Catecholamines biological_process owl:Class
GO:0031870 biolink:NamedThing thromboxane A2 receptor binding Binding to a thromboxane A2 receptor. got7fsn_ti thromboxane A2 receptor ligand|prostanoid TP receptor binding molecular_function owl:Class
GO:0044609 biolink:NamedThing DBIRD complex A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD. got7fsn_ti jl 2012-05-30T03:04:23Z cellular_component owl:Class
GO:0070114 biolink:NamedThing organellar chromatophore outer membrane The outer, i.e. cytoplasm-facing, of the two lipid bilayers surrounding an organellar chromatophore. got7fsn_ti Paulinella-type chromatophore outer membrane cellular_component owl:Class
GO:0061493 biolink:NamedThing central plaque of mitotic spindle pole body One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body. got7fsn_ti dph 2012-12-11T09:08:26Z cellular_component owl:Class
GO:0090543 biolink:NamedThing Flemming body A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge. got7fsn_ti Midbody ring tb 2013-02-14T17:24:43Z cellular_component owl:Class
GO:0019087 biolink:NamedThing transformation of host cell by virus A virus-induced cellular transformation resulting in immortalized cells, or cells capable of indefinite replication. got7fsn_ti host cell transformation|immortalization of host cell|viral transformation of host cell|transformation of host cell|viral immortalization|host cell immortalization|viral transformation|immortalization of host cell by virus GO:0020021|GO:0019088 Wikipedia:Viral_transformation biological_process owl:Class
GO:0034527 biolink:NamedThing 1,2-dihydroxy-8-carboxynaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-8-carboxynaphthalene + O2 = 2-carboxy-2-hydroxy-8-carboxychromene. got7fsn_ti UM-BBD_reactionID:r0790 molecular_function owl:Class
GO:0003104 biolink:NamedThing positive regulation of glomerular filtration Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule. got7fsn_ti biological_process owl:Class
GO:0004380 biolink:NamedThing glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose. got7fsn_ti histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)|A transferase activity|A-transferase activity|UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity|blood-group substance alpha-acetyltransferase activity|blood-group substance A-dependent acetylgalactosaminyltransferase activity|fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity|histo-blood group A transferase activity|fucosylgalactose acetylgalactosaminyltransferase activity|UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity|fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity|alpha-3-N-acetylgalactosaminyltransferase activity|histo-blood group A acetylgalactosaminyltransferase activity MetaCyc:2.4.1.40-RXN|RHEA:19021|Reactome:R-HSA-9034042|EC:2.4.1.40|Reactome:R-HSA-9033959 molecular_function owl:Class
GO:0019501 biolink:NamedThing arsonoacetate catabolic process The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom. got7fsn_ti arsonoacetate degradation|arsonoacetate breakdown|arsonoacetate catabolism MetaCyc:P482-PWY biological_process owl:Class
GO:0072482 biolink:NamedThing response to mitotic cell cycle spindle orientation checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle spindle orientation checkpoint signaling. got7fsn_ti response to signal involved in mitotic cell cycle spindle orientation checkpoint|mitotic cell cycle spindle orientation checkpoint effector process mah 2010-12-09T12:11:56Z biological_process owl:Class
GO:0072476 biolink:NamedThing response to mitotic spindle checkpoint signaling A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling. got7fsn_ti response to mitotic cell cycle spindle checkpoint signaling|mitotic cell cycle spindle checkpoint effector process|response to signal involved in mitotic cell cycle spindle checkpoint mah 2010-12-09T11:50:09Z biological_process owl:Class
GO:0072167 biolink:NamedThing specification of mesonephric tubule identity The process in which the tubules of the mesonephros acquire their identity. got7fsn_ti mah 2010-02-26T01:51:03Z biological_process owl:Class
GO:0060387 biolink:NamedThing fertilization envelope A structure that lies outside the plasma membrane and surrounds the egg. The fertilization envelope forms from the vitelline membrane after fertilization as a result of cortical granule release. got7fsn_ti fertilization membrane cellular_component owl:Class
GO:0102826 biolink:NamedThing kaempferol-3-glucoside-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside <=> kaempferol 3,7-O-diglucoside + UDP. got7fsn_ti MetaCyc:RXN-8270 molecular_function owl:Class
GO:0051757 biolink:NamedThing meiotic sister chromatid separation The process in which sister chromatids are physically detached from each other during meiosis. got7fsn_ti meiotic sister chromatid resolution biological_process owl:Class
GO:0032449 biolink:NamedThing CBM complex A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation. got7fsn_ti CARMA1-BCL10-Malt1 complex https://github.com/geneontology/go-ontology/issues/21010 cellular_component owl:Class
GO:0047971 biolink:NamedThing guanidinobutyrase activity Catalysis of the reaction: 4-guanidinobutanoate + H(2)O = 4-aminobutanoate + urea. got7fsn_ti gamma-guanidinobutyrate amidinohydrolase activity|G-base activity|4-guanidinobutyrate amidinobutyrase activity|gamma-guanidobutyrase activity|guanidinobutyrate ureahydrolase activity|GBH|4-guanidinobutanoate amidinohydrolase activity MetaCyc:GUANIDINOBUTYRASE-RXN|KEGG_REACTION:R01990|EC:3.5.3.7|RHEA:19501 molecular_function owl:Class
GO:0048724 biolink:NamedThing epistomal sclerite development The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0019092 biolink:NamedThing mitochondrial srRNA export from mitochondrion The process in which a srRNA, small subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol. got7fsn_ti mitochondrial srRNA, mitochondrial export|mitochondrial srRNA export from mitochondria|mitochondrial srRNA transport from mitochondrion|mitochondrial srRNA export|export of mitochondrial srRNA|mitochondrial srRNA export out of mitochondrion biological_process owl:Class
GO:0019090 biolink:NamedThing mitochondrial rRNA export from mitochondrion The process in which a rRNA, ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol. got7fsn_ti mitochondrial rRNA, mitochondrial export|mitochondrial rRNA transport from mitochondrion|mitochondrial rRNA export from mitochondria|mitochondrial rRNA export|mitochondrial rRNA export out of mitochondrion|export of mitochondrial rRNA biological_process owl:Class
GO:0061046 biolink:NamedThing regulation of branching involved in lung morphogenesis Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. got7fsn_ti dph 2010-02-25T10:41:38Z biological_process owl:Class
GO:0033444 biolink:NamedThing AAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AAG codon. got7fsn_ti lysine tRNA Note that in the standard genetic code, AAG codes for lysine. molecular_function owl:Class
GO:0047782 biolink:NamedThing coniferin beta-glucosidase activity Catalysis of the reaction: H2O + coniferin = D-glucose + coniferol. got7fsn_ti coniferin beta-D-glucosidase activity|coniferin-hydrolyzing beta-glucosidase activity|coniferin b-glucosidase activity RHEA:12252|MetaCyc:CONIFERIN-BETA-GLUCOSIDASE-RXN|EC:3.2.1.126 molecular_function owl:Class
GO:0052821 biolink:NamedThing DNA-7-methyladenine glycosylase activity Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site. got7fsn_ti ai 2011-10-28T02:27:39Z EC:3.2.2.21|MetaCyc:3.2.2.21-RXN molecular_function owl:Class
GO:0075199 biolink:NamedThing positive regulation of symbiont haustorium neck formation for entry into host Any process that activates, maintains or increases the frequency, rate or extent of symbiont haustorium neck formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0003743 biolink:NamedThing translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. got7fsn_ti GO:0003744|GO:0003745 Reactome:R-HSA-72722|Reactome:R-HSA-72621|Reactome:R-HSA-72697 molecular_function owl:Class
GO:0044173 biolink:NamedThing host cell endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system. got7fsn_ti host cell ER-Golgi intermediate compartment membrane|host endoplasmic reticulum-Golgi intermediate compartment membrane|host ER-Golgi intermediate compartment membrane jl 2009-09-04T02:46:13Z cellular_component owl:Class
GO:0090164 biolink:NamedThing asymmetric Golgi ribbon formation The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity. got7fsn_ti tb 2009-12-08T09:02:45Z biological_process owl:Class
GO:0045059 biolink:NamedThing positive thymic T cell selection The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death. got7fsn_ti positive thymic T-cell selection|positive thymic T lymphocyte selection|positive thymic T-lymphocyte selection biological_process owl:Class
GO:0050210 biolink:NamedThing prenyl-diphosphatase activity Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate. got7fsn_ti prenyl-pyrophosphatase activity|prenyl-diphosphate diphosphohydrolase activity|prenylphosphatase activity|prenol pyrophosphatase activity EC:3.1.7.1|RHEA:21496|MetaCyc:PRENYL-PYROPHOSPHATASE-RXN molecular_function owl:Class
GO:0051995 biolink:NamedThing Se-methyltransferase activity Catalysis of the transfer of a methyl group to the selenium atom of an acceptor molecule. got7fsn_ti ai 2010-07-16T04:48:08Z molecular_function owl:Class
GO:0005993 biolink:NamedThing trehalose catabolic process The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. got7fsn_ti mykose catabolism|trehalose degradation|mycose catabolic process|trehalose breakdown|trehalose catabolism|mykose catabolic process|mycose catabolism MetaCyc:TREDEGLOW-PWY biological_process owl:Class
GO:0071294 biolink:NamedThing cellular response to zinc ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. got7fsn_ti cellular response to zinc mah 2009-12-10T04:17:10Z biological_process owl:Class
GO:0070012 biolink:NamedThing oligopeptidase activity Catalysis of the hydrolysis of a peptide bond in an oligopeptide, i.e. a molecule containing a small number (2 to 20) of amino acid residues connected by peptide bonds. got7fsn_ti molecular_function owl:Class
GO:0051957 biolink:NamedThing positive regulation of amino acid transport Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti up-regulation of amino acid transport|activation of amino acid transport|up regulation of amino acid transport|positive regulation of amino acid transmembrane transport|upregulation of amino acid transport|stimulation of amino acid transport biological_process owl:Class
GO:0000769 biolink:NamedThing syncytium formation by mitosis without cytokinesis The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis. got7fsn_ti syncytium formation by mitosis without cell division biological_process owl:Class
GO:0060779 biolink:NamedThing secondary leaflet morphogenesis The process in which the secondary leaflet attains its shape. A secondary leaflet develops by branching or division of a primary leaflet. got7fsn_ti dph 2009-07-25T07:19:02Z biological_process owl:Class
GO:0046789 biolink:NamedThing host cell surface receptor binding Binding to a receptor on the host cell surface. got7fsn_ti cell surface antigen activity, host-interacting|cell surface receptor ligand molecular_function owl:Class
GO:0046812 biolink:NamedThing host cell surface binding Binding to the surface of a host cell. got7fsn_ti molecular_function owl:Class
GO:0033811 biolink:NamedThing flavonol-3-O-triglucoside O-coumaroyltransferase activity Catalysis of the reaction: 4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]. got7fsn_ti 4-coumaroyl-CoA:flavonol-3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] 6'''-O-4-coumaroyltransferase activity MetaCyc:2.3.1.173-RXN|EC:2.3.1.173|RHEA:22160 molecular_function owl:Class
GO:1903439 biolink:NamedThing calcitonin family receptor complex A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far. got7fsn_ti pr 2014-09-16T13:25:11Z cellular_component owl:Class
GO:1990422 biolink:NamedThing glyoxalase (glycolic acid-forming) activity Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor. got7fsn_ti bf 2014-07-21T09:00:21Z molecular_function owl:Class
GO:0004015 biolink:NamedThing adenosylmethionine-8-amino-7-oxononanoate transaminase activity Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate. got7fsn_ti DAPA aminotransferase activity|7,8-diaminononanoate aminotransferase activity|adenosyl methionine-8-amino-7-oxononanoate transaminase activity|7,8-diaminononanoate transaminase activity|adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity|7,8-diaminonanoate transaminase activity|adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity|7-keto-8-aminopelargonic acid|S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity|7-keto-8-aminopelargonic acid aminotransferase activity|7,8-diaminopelargonic acid aminotransferase activity|DAPA transaminase activity|diaminopelargonate synthase activity|7,8-diamino-pelargonic acid aminotransferase activity RHEA:16861|MetaCyc:DAPASYN-RXN|KEGG_REACTION:R03231|EC:2.6.1.62 molecular_function owl:Class
GO:0038142 biolink:NamedThing EGFR:ERBB2 complex A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR. got7fsn_ti EGFR:ERBB2 heterodimer|EGF:EGFR:ERBB2 complex bf 2012-03-30T02:10:38Z cellular_component owl:Class
GO:0098006 biolink:NamedThing viral DNA genome packaging, headful The encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full. got7fsn_ti phage headful packaging Generalized transducing phages usually use this mode of DNA packaging. bm 2012-07-18T16:15:09Z biological_process owl:Class
GO:0102745 biolink:NamedThing dihydrogeranylgeranyl-PP reductase activity Catalysis of the reaction: H+ + dihydrogeranylgeranyl-PP + NADPH = tetrahydrogeranylgeranyl-PP + NADP. got7fsn_ti MetaCyc:RXN-7659 molecular_function owl:Class
GO:0050805 biolink:NamedThing negative regulation of synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. got7fsn_ti down-regulation of synaptic transmission|inhibition of synaptic transmission|down regulation of synaptic transmission|downregulation of synaptic transmission biological_process owl:Class
GO:0050131 biolink:NamedThing N-methyl-L-amino-acid oxidase activity Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2. got7fsn_ti N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)|N-methylamino acid oxidase activity MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN|EC:1.5.3.2|RHEA:11472 molecular_function owl:Class
GO:0071066 biolink:NamedThing detection of mechanical stimulus involved in sensory perception of wind The series of events involved in the perception of wind in which a mechanical stimulus is received and converted into a molecular signal. got7fsn_ti sensory detection of mechanical stimulus during perception of wind|perception of wind, detection of mechanical stimulus|perception of wind, sensory detection of mechanical stimulus|perception of wind, sensory transduction of mechanical stimulus|detection of mechanical stimulus involved in sensory perception of air flow|detection of wind|sensory transduction of wind|sensory transduction of mechanical stimulus during perception of wind mah 2009-11-04T02:47:36Z biological_process owl:Class
GO:0030268 biolink:NamedThing methylenetetrahydromethanopterin dehydrogenase activity Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420. got7fsn_ti 5,10-methylenetetrahydromethanopterin dehydrogenase activity|N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity|5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity GO:0018536 EC:1.5.98.1|MetaCyc:1.5.99.9-RXN|UM-BBD_reactionID:r0348|KEGG_REACTION:R04456|RHEA:16721 molecular_function owl:Class
GO:0030310 biolink:NamedThing poly-N-acetyllactosamine catabolic process The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n. got7fsn_ti poly-N-acetyllactosamine degradation|poly-N-acetyllactosamine breakdown|poly-N-acetyllactosamine catabolism biological_process owl:Class
GO:0047694 biolink:NamedThing barbiturase activity Catalysis of the reaction: barbiturate + H2O = malonate + urea. got7fsn_ti barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming) MetaCyc:BARBITURASE-RXN|EC:3.5.2.1|RHEA:18653 molecular_function owl:Class
GO:0034425 biolink:NamedThing etioplast envelope The double lipid bilayer enclosing the etioplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. got7fsn_ti cellular_component owl:Class
GO:0070177 biolink:NamedThing contractile vacuole discharge The regulated release of water from a contractile vacuole to the outside of a cell by fusion of the contractile vacuole membrane with the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0021898 biolink:NamedThing commitment of multipotent stem cells to neuronal lineage in forebrain The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain. got7fsn_ti biological_process owl:Class
GO:0014883 biolink:NamedThing transition between fast and slow fiber The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. got7fsn_ti transition fast-slow fiber|transition fast-slow fibre|transition between fast and slow fibre biological_process owl:Class
GO:0002793 biolink:NamedThing positive regulation of peptide secretion Any process that activates or increases the frequency, rate, or extent of peptide secretion. got7fsn_ti up regulation of peptide secretion|up-regulation of peptide secretion|upregulation of peptide secretion|activation of peptide secretion|stimulation of peptide secretion biological_process owl:Class
GO:0019513 biolink:NamedThing lactose catabolic process, using glucoside 3-dehydrogenase The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13). got7fsn_ti lactose breakdown, using glucoside 3-dehydrogenase|lactose degradation, using glucoside 3-dehydrogenase MetaCyc:LACTOSEUTIL-PWY biological_process owl:Class
GO:0005990 biolink:NamedThing lactose catabolic process The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose. got7fsn_ti lactose catabolism|lactose breakdown|lactose degradation biological_process owl:Class
GO:0006877 biolink:NamedThing cellular cobalt ion homeostasis Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell. got7fsn_ti cobalt homeostasis biological_process owl:Class
GO:0055068 biolink:NamedThing cobalt ion homeostasis Any process involved in the maintenance of an internal steady state of cobalt ions within an organism or cell. got7fsn_ti cobalt homeostasis biological_process owl:Class
GO:0044564 biolink:NamedThing envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism. got7fsn_ti jl 2012-04-05T04:14:24Z biological_process owl:Class
GO:0033842 biolink:NamedThing N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + N-acetyl-beta-D-glucosaminyl group = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl group. got7fsn_ti beta1,4-N-acetylgalactosaminyltransferase III activity|beta1,4-N-acetylgalactosaminyltransferase activity|beta4GalNAc-T3|UDP-N-acetyl-D-galactosamine:N-acetyl-D-glucosaminyl-group beta-1,4-N-acetylgalactosaminyltransferase activity|beta1,4-N-acetylgalactosaminyltransferase IV activity|beta4GalNAc-T4 MetaCyc:2.4.1.244-RXN|RHEA:20493|EC:2.4.1.244 molecular_function owl:Class
GO:0060698 biolink:NamedThing endoribonuclease inhibitor activity Binds to and stops, prevents or reduces the activity of endoribonuclease. got7fsn_ti dph 2009-06-08T02:37:19Z molecular_function owl:Class
GO:0102802 biolink:NamedThing thebaine 6-O-demethylase activity Catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-8147|RHEA:27477|EC:1.14.11.31 molecular_function owl:Class
GO:0043125 biolink:NamedThing ErbB-3 class receptor binding Binding to the protein-tyrosine kinase receptor ErbB-3/HER3. got7fsn_ti Neu/ErbB-2 receptor activity|HER3 receptor binding molecular_function owl:Class
GO:0043542 biolink:NamedThing endothelial cell migration The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. got7fsn_ti biological_process owl:Class
GO:0071126 biolink:NamedThing alphaV-beta6 integrin-osteopontin complex A protein complex that consists of an alphaV-beta6 integrin complex bound to osteopontin. got7fsn_ti ITGAV-ITGB6-SPP1 complex mah 2009-11-13T02:23:43Z cellular_component owl:Class
GO:0050690 biolink:NamedThing regulation of defense response to virus by virus Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism. got7fsn_ti regulation by virus of antiviral response|regulation of antiviral response by virus|viral regulation of antiviral response biological_process owl:Class
GO:0070747 biolink:NamedThing interleukin-35 receptor activity Combining with interleukin-35 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-35 receptor activity|IL-35R mah 2009-06-23T01:18:09Z molecular_function owl:Class
GO:0018511 biolink:NamedThing 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH. got7fsn_ti cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity KEGG_REACTION:R05240|UM-BBD_reactionID:r0396|MetaCyc:RXN-665|EC:1.3.1.58|RHEA:23772 molecular_function owl:Class
GO:0090087 biolink:NamedThing regulation of peptide transport Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti tb 2009-10-23T11:21:38Z biological_process owl:Class
GO:0047003 biolink:NamedThing dTDP-6-deoxy-L-talose 4-dehydrogenase activity Catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH. got7fsn_ti TDP-6-deoxy-L-talose dehydrogenase activity|dTDP-6-deoxy-L-talose:NADP+ 4-oxidoreductase activity|dTDP-6-deoxy-L-talose dehydrogenase (4-reductase)|thymidine diphospho-6-deoxy-L-talose dehydrogenase activity KEGG_REACTION:R02776|MetaCyc:1.1.1.134-RXN|EC:1.1.1.134|RHEA:23648 molecular_function owl:Class
GO:0047787 biolink:NamedThing delta4-3-oxosteroid 5beta-reductase activity Catalysis of the reactions: (1) 5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+ and (2) 17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+. got7fsn_ti cortisone 5beta-reductase activity|delta(4)-hydrogenase activity|delta4-hydrogenase activity|androstenedione 5-beta-reductase activity|cholestenone 5b-reductase activity|cortisone b-reductase activity|cortisone 5-beta-reductase activity|cortisone beta-reductase activity|cholestenone 5beta-reductase activity|5beta-cholestan-3-one:NADP+ 4,5-oxidoreductase activity|delta4-5beta-reductase activity|delta(4)-5-beta-reductase activity|steroid 5beta-reductase activity|4,5beta-dihydrocortisone:NADP+ delta4-oxidoreductase activity|cholestenone 5-beta-reductase activity|3-oxo-5beta-steroid:NADP+ delta4-oxidoreductase activity|delta(4)-3-ketosteroid 5-beta-reductase activity|5-beta-reductase activity|androstenedione 5beta-reductase activity|cortisone delta(4)-5-beta-reductase activity|cortisone delta4-5beta-reductase activity|testosterone 5-beta-reductase activity|5beta-reductase activity|delta4-3-ketosteroid 5beta-reductase activity|testosterone 5beta-reductase activity|3-oxo-Delta(4)-steroid 5-beta-reductase activity|steroid 5-beta-reductase activity|3-oxo-delta4-steroid 5beta-reductase activity|delta4-3-oxosteroid 5-beta-reductase activity GO:0047752 EC:1.3.1.3|MetaCyc:CHOLESTENONE-5-BETA-REDUCTASE-RXN|MetaCyc:CORTISONE-BETA-REDUCTASE-RXN molecular_function owl:Class
GO:0009093 biolink:NamedThing cysteine catabolic process The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid. got7fsn_ti cysteine degradation|cysteine catabolism|cysteine breakdown Wikipedia:Cysteine biological_process owl:Class
GO:0035243 biolink:NamedThing protein-arginine omega-N symmetric methyltransferase activity Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N'(omega)-dimethyled arginine residues. got7fsn_ti type II PRMT activity|type II protein arginine methyltransferase activity|S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega'-dimethyl-L-arginine-forming) Note that type II protein arginine N-methyltransferase enzymes possess 'protein-arginine omega-N monomethyltransferase activity ; GO:0035241' and 'protein-arginine omega-N symmetric methyltransferase activity ; GO:0035243'. EC:2.1.1.320|Reactome:R-HSA-6804383|RESID:AA0069|RHEA:48108|RESID:AA0067 molecular_function owl:Class
GO:0048926 biolink:NamedThing electrosensory lateral line system development The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0051719 biolink:NamedThing DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN. got7fsn_ti Reactome:R-HSA-5334097|Reactome:R-HSA-5334152 molecular_function owl:Class
GO:0006629 biolink:NamedThing lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. got7fsn_ti lipid metabolism Wikipedia:Lipid_metabolism biological_process owl:Class
GO:0106158 biolink:NamedThing glycero-3-phosphocholine acyltransferase activity Catalysis of the reaction:acyl-CoA + glycerophosphocholine = CoA + 1-acyl-sn-glycero-3-phosphocholine. got7fsn_ti GPACT activity|glycerophosphocholine O-acyltransferase activity|glycero-3-phosphocholine acyltransferase activity https://github.com/geneontology/go-ontology/issues/16665 hjd 2018-11-26T21:21:03Z RHEA:58476 molecular_function owl:Class
GO:0102537 biolink:NamedThing ecdysone-phosphate phosphatase activity Catalysis of the reaction: ecdysone 22-phosphate + H2O <=> ecdysone + hydrogenphosphate. got7fsn_ti MetaCyc:RXN-14766 molecular_function owl:Class
GO:0042654 biolink:NamedThing ecdysis-triggering hormone receptor activity Combining with ecdysis-triggering hormone to initiate a change in cell activity. got7fsn_ti ecdysis-triggering hormone binding|ETH receptor molecular_function owl:Class
GO:0102590 biolink:NamedThing delphinidin 3-O-rutinoside 7-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: delphinidin 3-O-rutinoside + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> delphinidin 3-O-rutinoside-7-O-glucoside + 4-hydroxybenzoic acid + H+. got7fsn_ti MetaCyc:RXN-15351 molecular_function owl:Class
GO:0071190 biolink:NamedThing protocadherin-alpha-v7-protocadherin-gamma-b2 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b2, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdha7-Pcdhgb4 complex mah 2009-11-23T04:30:12Z cellular_component owl:Class
GO:0103009 biolink:NamedThing 3-chlorotoluene monooxygenase activity Catalysis of the reaction: H+ + 3-chlorotoluene + NADH + O2 <=> 3-chlorobenzyl alcohol + NAD + H2O. got7fsn_ti MetaCyc:RXN-9908 molecular_function owl:Class
GO:0046449 biolink:NamedThing creatinine metabolic process The chemical reactions and pathways involving creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine. got7fsn_ti creatinine metabolism biological_process owl:Class
GO:0050028 biolink:NamedThing L-lysine-lactamase activity Catalysis of the reaction: L-2-aminohexano-6-lactam + H(2)O = L-lysine. got7fsn_ti L-lysinamidase activity|L-alpha-aminocaprolactam hydrolase activity|L-lysine-1,6-lactam lactamhydrolase activity RHEA:21388|KEGG_REACTION:R00463|EC:3.5.2.11|MetaCyc:L-LYSINE-LACTAMASE-RXN molecular_function owl:Class
GO:0097042 biolink:NamedThing extrinsic component of fungal-type vacuolar membrane The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to fungal-type vacuolar membrane pr 2011-04-19T03:42:39Z cellular_component owl:Class
GO:0000306 biolink:NamedThing extrinsic component of vacuolar membrane The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to vacuolar membrane cellular_component owl:Class
GO:0008313 biolink:NamedThing gurken-activated receptor activity Combining with the ligand Gurken to initiate a change in cell activity. got7fsn_ti gurken receptor activity molecular_function owl:Class
GO:0039584 biolink:NamedThing suppression by virus of host protein kinase activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity. got7fsn_ti bf 2012-05-02T03:04:55Z biological_process owl:Class
GO:0051127 biolink:NamedThing positive regulation of actin nucleation Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament. got7fsn_ti stimulation of actin nucleation|up-regulation of actin nucleation|upregulation of actin nucleation|up regulation of actin nucleation|activation of actin nucleation biological_process owl:Class
GO:0006545 biolink:NamedThing glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. got7fsn_ti glycine formation|glycine synthesis|glycine anabolism|glycine biosynthesis MetaCyc:GLYCINE-SYN2-PWY biological_process owl:Class
GO:0034460 biolink:NamedThing uropod assembly The assembly of a uropod by rearrangement of the cytoskeleton and overlying membrane. got7fsn_ti uropod formation biological_process owl:Class
GO:0001543 biolink:NamedThing ovarian follicle rupture Disruption of theca cell layer releasing follicular fluid and/or the oocyte. got7fsn_ti biological_process owl:Class
GO:1901269 biolink:NamedThing lipooligosaccharide metabolic process The chemical reactions and pathways involving lipooligosaccharide. got7fsn_ti lipooligosaccharide metabolism yaf 2012-08-17T14:31:26Z biological_process owl:Class
GO:0006858 biolink:NamedThing extracellular transport The transport of substances that occurs outside cells. got7fsn_ti biological_process owl:Class
GO:0032924 biolink:NamedThing activin receptor signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti activin receptor signalling pathway biological_process owl:Class
GO:0031945 biolink:NamedThing positive regulation of glucocorticoid metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids. got7fsn_ti up-regulation of glucocorticoid metabolic process|upregulation of glucocorticoid metabolic process|positive regulation of glucocorticoid metabolism|up regulation of glucocorticoid metabolic process|activation of glucocorticoid metabolic process|stimulation of glucocorticoid metabolic process biological_process owl:Class
GO:0072165 biolink:NamedThing anterior mesonephric tubule development The progression of the anterior mesonephric tubule over time, from its initial formation to the mature structure. The anterior mesonephric tubule is an epithelial tube that is part of the mesonephros. got7fsn_ti mah 2010-02-26T01:47:26Z biological_process owl:Class
GO:0003841 biolink:NamedThing 1-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. got7fsn_ti 1-acyl-sn-glycerol-3-phosphate acyltransferase activity|1-acylglycero-3-phosphate acyltransferase activity|1-acyl-sn-glycerol 3-phosphate acyltransferase activity|1-acyl-sn-glycero-3-phosphate acyltransferase activity|lysophosphatidate acyltransferase activity|1-acylglycerophosphate acyltransferase activity|acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity|1-acylglycerolphosphate acyltransferase activity|lysophosphatidic acid-acyltransferase activity GO:0004469 MetaCyc:RXN-1623|Reactome:R-HSA-1482667|Reactome:R-HSA-1482894|Reactome:R-HSA-1482689|Reactome:R-HSA-1482598|Reactome:R-HSA-75885|RHEA:19709|Reactome:R-HSA-1482547|Reactome:R-HSA-1482548|Reactome:R-HSA-1482539|Reactome:R-HSA-8849345|Reactome:R-HSA-1482636|EC:2.3.1.51 molecular_function owl:Class
GO:0034832 biolink:NamedThing geranial dehydrogenase activity Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+. got7fsn_ti UM-BBD_reactionID:r1164 molecular_function owl:Class
GO:0044298 biolink:NamedThing cell body membrane The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections. got7fsn_ti cell soma membrane jl 2010-02-05T10:39:23Z cellular_component owl:Class
GO:0042859 biolink:NamedThing chrysobactin catabolic process The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). got7fsn_ti chrysobactin breakdown|chrysobactin degradation|chrysobactin catabolism biological_process owl:Class
GO:0046215 biolink:NamedThing siderophore catabolic process The chemical reactions and pathways resulting in the breakdown of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action. got7fsn_ti siderophore catabolism|siderochrome catabolism|siderophore degradation|siderophore breakdown biological_process owl:Class
GO:0008389 biolink:NamedThing coumarin 7-hydroxylase activity Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. got7fsn_ti cytochrome P450 CYP2A5 Reactome:R-HSA-211881|Reactome:R-HSA-76453 molecular_function owl:Class
GO:0050558 biolink:NamedThing maltose epimerase activity Catalysis of the reaction: alpha-maltose = beta-maltose. got7fsn_ti maltose 1-epimerase activity MetaCyc:5.1.3.21-RXN|RHEA:21228|KEGG_REACTION:R07319|EC:5.1.3.21 molecular_function owl:Class
GO:0015652 biolink:NamedThing quaternary ammonium group:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in). got7fsn_ti quaternary ammonium group:hydrogen symporter activity molecular_function owl:Class
GO:1990161 biolink:NamedThing DnaB helicase complex A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair. got7fsn_ti DnaB hexamer bhm 2013-08-02T15:55:48Z cellular_component owl:Class
GO:0002754 biolink:NamedThing intracellular endosomal pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. got7fsn_ti intracellular vesicle pattern recognition receptor signaling pathway|intracellular vesicle PAMP receptor signaling pathway|intracellular vesicle PRR signaling pathway|intracellular vesicle pathogen receptor signaling pathway|intracellular vesicle pattern recognition receptor signalling pathway https://github.com/geneontology/go-ontology/issues/18679 biological_process owl:Class
GO:0045450 biolink:NamedThing bicoid mRNA localization Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis. got7fsn_ti establishment and maintenance of bicoid mRNA localization|bicoid mRNA localisation biological_process owl:Class
GO:0060811 biolink:NamedThing intracellular mRNA localization involved in anterior/posterior axis specification Any process in which mRNA is transported to, or maintained in, a specific location within the oocyte and/or syncytial embryo that contributes to the specification of the anterior/posterior axis. got7fsn_ti intracellular mRNA localisation involved in anterior/posterior axis specification dph 2009-08-07T09:26:22Z biological_process owl:Class
GO:0043585 biolink:NamedThing nose morphogenesis The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity). got7fsn_ti nasus morphogenesis biological_process owl:Class
GO:0031975 biolink:NamedThing envelope A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. got7fsn_ti cellular_component owl:Class
GO:0050843 biolink:NamedThing S-adenosylmethionine catabolic process The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. got7fsn_ti S-adenosyl methionine catabolic process|SAM catabolic process|S-adenosylmethionine breakdown|S-adenosylmethionine catabolism|S-adenosylmethionine degradation|S-adenosyl methionine catabolism biological_process owl:Class
GO:0048377 biolink:NamedThing lateral mesodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into a lateral mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti lateral mesoderm cell fate specification|lateral plate mesodermal cell fate specification|lateral plate mesoderm cell fate specification biological_process owl:Class
GO:0072522 biolink:NamedThing purine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. got7fsn_ti purine-containing compound biosynthesis|purine-containing compound anabolism|purine and derivative biosynthetic process|purine-containing compound formation|purine-containing compound synthesis mah 2011-01-04T03:15:29Z biological_process owl:Class
GO:0034122 biolink:NamedThing negative regulation of toll-like receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. got7fsn_ti negative regulation of TLR signaling pathway|negative regulation of toll-like receptor signalling pathway biological_process owl:Class
GO:0046990 biolink:NamedThing N-hydroxyarylamine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine. got7fsn_ti arylhydroxamate N,O-acetyltransferase activity|N-hydroxy-2-aminofluorene-O-acetyltransferase activity|acetyl-CoA:N-hydroxyarylamine O-acetyltransferase activity MetaCyc:2.3.1.118-RXN|EC:2.3.1.118|RHEA:20277 molecular_function owl:Class
GO:0001725 biolink:NamedThing stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. got7fsn_ti stress fibre|actin cable cellular_component owl:Class
GO:0047078 biolink:NamedThing 3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity Catalysis of the reaction: O2 + 3-hydroxy-1H-quinolin-4-one = carbon monoxide + N-formylanthranilate. got7fsn_ti 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity|3-hydroxy-4(1H)-one, 2,4-dioxygenase activity|quinoline-3,4-diol 2,4-dioxygenase activity|3-hydroxy-4-oxo-1,4-dihydroquinoline 2,4-dioxygenase activity|3-hydroxy-1H-quinolin-4-one 2,4-dioxygenase (CO-forming)|(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity RHEA:17949|EC:1.13.11.47|MetaCyc:1.13.11.47-RXN molecular_function owl:Class
GO:1900601 biolink:NamedThing endocrocin catabolic process The chemical reactions and pathways resulting in the breakdown of endocrocin. got7fsn_ti endocrocin degradation|endocrocin breakdown|endocrocin catabolism di 2012-05-15T06:57:34Z biological_process owl:Class
GO:0052615 biolink:NamedThing ent-kaurene oxidase activity Catalysis of the reaction: H+ + NADPH + ent-kaur-16-ene + oxygen = H2O + NADP+ + ent-kaur-16-en-19-ol. got7fsn_ti RHEA:32323|MetaCyc:1.14.13.78-RXN|EC:1.14.14.86 molecular_function owl:Class
GO:2000908 biolink:NamedThing positive regulation of glucomannan catabolic process Any process that activates or increases the frequency, rate or extent of glucomannan catabolic process. got7fsn_ti positive regulation of glucomannan catabolism tt 2011-07-29T01:13:30Z biological_process owl:Class
GO:2000996 biolink:NamedThing positive regulation of mannan catabolic process Any process that activates or increases the frequency, rate or extent of mannan catabolic process. got7fsn_ti positive regulation of mannan catabolism|positive regulation of mannan breakdown|positive regulation of mannan degradation tt 2011-08-08T03:19:18Z biological_process owl:Class
GO:0007429 biolink:NamedThing secondary branching, open tracheal system Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster. got7fsn_ti secondary tracheal branching biological_process owl:Class
GO:0000176 biolink:NamedThing nuclear exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. got7fsn_ti nuclear exosome multienzyme ribonuclease complex|eukaryotic exosome multienzyme ribonuclease complex|nuclear exosome (ribonuclease complex) cellular_component owl:Class
GO:0034493 biolink:NamedThing melanosome lumen The volume enclosed by the melanosome membrane. got7fsn_ti cellular_component owl:Class
GO:0046354 biolink:NamedThing mannan biosynthetic process The chemical reactions and pathways resulting in the formation of mannan, the main hemicellulose of soft (coniferous) wood, made up of D-mannose, D-glucose and D-galactose. got7fsn_ti mannan biosynthesis|mannan synthesis|mannan anabolism|mannan formation biological_process owl:Class
GO:0035159 biolink:NamedThing regulation of tube length, open tracheal system Ensuring that a tube in an open tracheal system is of the correct length. got7fsn_ti regulation of tracheal tube length|tracheal tube elongation biological_process owl:Class
GO:0035151 biolink:NamedThing regulation of tube size, open tracheal system Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape. got7fsn_ti regulation of tracheal tube size biological_process owl:Class
GO:0031244 biolink:NamedThing extrinsic component of cell outer membrane The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to cell outer membrane cellular_component owl:Class
GO:0046720 biolink:NamedThing citric acid secretion The controlled release of citric acid, 2-hydroxy-1,2,3-propanetricarboxylic acid, by a cell or a tissue. got7fsn_ti citrate secretion biological_process owl:Class
GO:0070086 biolink:NamedThing ubiquitin-dependent endocytosis Endocytosis of a protein that requires the substrate to be modified by ubiquitination. Several plasma membrane proteins, including cell surface permeases and some receptors, are targeted for internalization by endocytosis, and are thereafter delivered to the vacuole or lysosome, where they are degraded. got7fsn_ti ubiquitin-mediated endocytosis biological_process owl:Class
GO:0002010 biolink:NamedThing excitation of vasomotor center by baroreceptor signaling The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure. got7fsn_ti excitation of vasomotor center by baroreceptor signalling biological_process owl:Class
GO:0103101 biolink:NamedThing UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 7-methylthioheptylhydroximate <=> H+ + 6-methylthiohexyldesulfoglucosinolate + UDP. got7fsn_ti MetaCyc:RXNQT-4326|EC:2.4.1.195 molecular_function owl:Class
GO:0032233 biolink:NamedThing positive regulation of actin filament bundle assembly Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles. got7fsn_ti up-regulation of actin filament bundle formation|up regulation of actin filament bundle formation|activation of actin filament bundle formation|upregulation of actin filament bundle formation|stimulation of actin filament bundle formation biological_process owl:Class
GO:0032428 biolink:NamedThing beta-N-acetylgalactosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides. got7fsn_ti MetaCyc:3.2.1.53-RXN|EC:3.2.1.53 molecular_function owl:Class
GO:0004563 biolink:NamedThing beta-N-acetylhexosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. got7fsn_ti beta-D-hexosaminidase activity|hexosaminidase A|beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity|N-acetyl-beta-glucosaminidase activity|beta-N-acetyl-D-hexosaminidase activity|beta-hexosaminidase activity|N-acetyl-beta-hexosaminidase activity|beta-D-N-acetylhexosaminidase activity|beta-acetylhexosaminidinase activity|beta-acetylaminodeoxyhexosidase activity|N-acetyl-beta-D-hexosaminidase activity|N-acetylhexosaminidase activity Reactome:R-HSA-9035976|Reactome:R-HSA-2162225|Reactome:R-HSA-1605595|Reactome:R-HSA-3662344|Reactome:R-HSA-9638075|Reactome:R-HSA-9035978|Reactome:R-HSA-9035983|EC:3.2.1.52|Reactome:R-HSA-1638053|Reactome:R-HSA-2105001|Reactome:R-HSA-1605632|MetaCyc:3.2.1.52-RXN|Reactome:R-HSA-3656259|Reactome:R-HSA-9638076|Reactome:R-HSA-9035982|Reactome:R-HSA-9638078 molecular_function owl:Class
GO:0050536 biolink:NamedThing (S)-N-acetyl-1-phenylethylamine hydrolase activity Catalysis of the reaction: N-acetylphenylethylamine + H(2)O = acetate + phenylethylamine. got7fsn_ti (S)-N-acetylphenylethylamine:H2O hydrolase activity|(S)-N-acetyl-1-phenylethylamine amidohydrolase activity RHEA:23952|EC:3.5.1.85|KEGG_REACTION:R07301|MetaCyc:3.5.1.85-RXN molecular_function owl:Class
GO:0072586 biolink:NamedThing DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity Binds to and modulates the activity of ATP-hydrolyzing DNA topoisomerase. DNA topoisomerase (ATP-hydrolyzing) regulator activity catalyzes a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. got7fsn_ti mah 2011-02-09T05:31:50Z molecular_function owl:Class
GO:0047758 biolink:NamedThing ATP:2-methylpropanoate phosphotransferase activity Catalysis of the reaction: 2-methylpropanoate + ATP = 2-methylpropanoyl phosphate + ADP + H(+). got7fsn_ti branched-chain fatty acid kinase activity|isobutyrate kinase activity|branched-chain-fatty-acid kinase activity|ATP:branched-chain-fatty-acid 1-phosphotransferase activity|ATP:2-methylpropanoate kinase activity|ATP:2-methylpropanoate 1-phosphotransferase activity|ATP:isobutyrate 1-phosphotransferase activity RHEA:24156|EC:2.7.2.14|KEGG_REACTION:R04002|MetaCyc:BRANCHED-CHAIN-FATTY-ACID-KINASE-RXN molecular_function owl:Class
GO:0044730 biolink:NamedThing bone sialoprotein binding Binding to a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin. got7fsn_ti bone sialoprotein II binding jl 2012-11-06T13:05:56Z InterPro:IPR008412 molecular_function owl:Class
GO:0050559 biolink:NamedThing copalyl diphosphate synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate. got7fsn_ti diterpene cyclase activity|(+)-copalyl-diphosphate lyase (decyclizing) MetaCyc:RXN-4861|EC:5.5.1.12|RHEA:24316|KEGG_REACTION:R06298 molecular_function owl:Class
GO:0004108 biolink:NamedThing citrate (Si)-synthase activity Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. got7fsn_ti citrate synthetase activity|citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity|citrate synthase activity|citrate oxaloacetate-lyase, CoA-acetylating activity|citric-condensing enzyme activity|condensing enzyme activity|citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]|citrate condensing enzyme activity|citrogenase activity|oxaloacetate transacetase activity|(R)-citric synthase activity|citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)|citric synthase activity|oxalacetic transacetase activity|acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] Note that this function was formerly EC:4.1.3.7. EC:2.3.3.1|Reactome:R-HSA-70975|MetaCyc:CITSYN-RXN molecular_function owl:Class
GO:0140517 biolink:NamedThing protein-RNA adaptor activity The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19409 pg 2020-09-11T09:12:05Z molecular_function owl:Class
GO:0008957 biolink:NamedThing phenylacetaldehyde dehydrogenase activity Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+. got7fsn_ti phenylacetaldehyde:NAD+ oxidoreductase activity RHEA:21392|EC:1.2.1.39|UM-BBD_reactionID:r0035|MetaCyc:PHENDEHYD-RXN molecular_function owl:Class
GO:0046860 biolink:NamedThing glycosome membrane The lipid bilayer surrounding a glycosome. got7fsn_ti cellular_component owl:Class
GO:0032243 biolink:NamedThing negative regulation of nucleoside transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti downregulation of nucleoside transport|inhibition of nucleoside transport|down-regulation of nucleoside transport|down regulation of nucleoside transport biological_process owl:Class
GO:0019757 biolink:NamedThing glycosinolate metabolic process The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae. got7fsn_ti glycosinolate metabolism biological_process owl:Class
GO:0097203 biolink:NamedThing phagocytic cup lip The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome. got7fsn_ti pr 2011-12-21T10:26:41Z cellular_component owl:Class
GO:0035999 biolink:NamedThing tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules. got7fsn_ti bf 2011-09-02T01:35:49Z UniPathway:UPA00193|MetaCyc:PWY-2201 biological_process owl:Class
GO:0098870 biolink:NamedThing action potential propagation The propagation of an action potential along the plane of an excitable membrane. Action potentials typically propagate once triggered because the depolarization of adjacent membrane regions due to an action potential crosses the firing threshold. got7fsn_ti biological_process owl:Class
GO:0061563 biolink:NamedThing trigeminal ganglion structural organization The process that contributes to creating the structural organization of the trigeminal ganglion This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti trigeminal ganglia organization dph 2013-07-10T09:12:11Z biological_process owl:Class
GO:0043830 biolink:NamedThing thiol-driven fumarate reductase activity Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide. got7fsn_ti EC:1.3.99.- molecular_function owl:Class
GO:0047325 biolink:NamedThing inositol tetrakisphosphate 1-kinase activity Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. got7fsn_ti inositol 3,4,5,6-tetrakisphosphate 1-kinase activity|1D-myo-inositol-trisphosphate 5-kinase activity|ATP:1D-myo-inositol-3,4,5,6-tetrakisphosphate 1-phosphotransferase activity|inositol-tetrakisphosphate 1-kinase activity|1D-myo-inositol-tetrakisphosphate 1-kinase activity|inositol-trisphosphate 6-kinase activity|inositol-trisphosphate 5-kinase activity|1D-myo-inositol-trisphosphate 6-kinase activity Reactome:R-HSA-994137|Reactome:R-HSA-1855162|EC:2.7.1.134|RHEA:12452|MetaCyc:2.7.1.134-RXN molecular_function owl:Class
GO:0034548 biolink:NamedThing N-cyclopropylammeline deaminase activity Catalysis of the reaction: N-cyclopropylammeline + H2O = N-cyclopropylammelide + NH3. got7fsn_ti UM-BBD_reactionID:r0826|MetaCyc:RXN-8019 molecular_function owl:Class
GO:0070770 biolink:NamedThing alphaIIb-beta3 integrin-CD47-FAK complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK. got7fsn_ti ITGA2b-ITGB3-CD47-FAK complex mah 2009-06-29T05:43:59Z cellular_component owl:Class
GO:0099640 biolink:NamedThing axo-dendritic protein transport The directed movement of proteins along microtubules in neuron projections. got7fsn_ti axonal protein transport biological_process owl:Class
GO:0048323 biolink:NamedThing axial mesodermal cell fate determination The process in which a cell becomes capable of differentiating autonomously into an axial mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti axial mesoderm cell fate determination biological_process owl:Class
GO:0085042 biolink:NamedThing periarbuscular membrane A host-derived membrane surrounding the symbiont arbuscule during symbiosis. got7fsn_ti See also: arbuscule ; GO:0085041. jl 2010-07-27T04:31:37Z cellular_component owl:Class
GO:0018721 biolink:NamedThing trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate. got7fsn_ti trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity UM-BBD_reactionID:r0559 molecular_function owl:Class
GO:0120198 biolink:NamedThing positive regulation of imaginal disc-derived wing size Any process that increases the size of an imaginal disc-derived wing. got7fsn_ti krc 2019-04-30T21:47:06Z biological_process owl:Class
GO:0099582 biolink:NamedThing neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol. got7fsn_ti neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels molecular_function owl:Class
GO:0061499 biolink:NamedThing outer plaque of mitotic spindle pole body One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm. got7fsn_ti dph 2012-12-11T09:18:43Z cellular_component owl:Class
GO:0018603 biolink:NamedThing nitrobenzene 1,2-dioxygenase activity Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol. got7fsn_ti UM-BBD_reactionID:r0306|EC:1.14.12.- molecular_function owl:Class
GO:0031361 biolink:NamedThing integral component of thylakoid membrane The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to thylakoid membrane cellular_component owl:Class
GO:0030317 biolink:NamedThing flagellated sperm motility The directed, self-propelled movement of a cilium (aka flagellum) that contributes to the movement of a flagellated sperm. got7fsn_ti sperm flagellum movement involved in flagellated sperm movement|flagellated sperm movement|sperm movement|sperm motility|sperm flagellum movement involved in flagellated sperm motility|sperm flagellum movement GO:1905419|GO:0097724 Wikipedia:Sperm_motility biological_process owl:Class
GO:0060294 biolink:NamedThing cilium movement involved in cell motility Movement of cilia mediated by motor proteins that contributes to the movement of a cell. got7fsn_ti biological_process owl:Class
GO:0061445 biolink:NamedThing endocardial cushion cell fate commitment The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell. got7fsn_ti dph 2012-03-13T09:11:03Z biological_process owl:Class
GO:0031433 biolink:NamedThing telethonin binding Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. got7fsn_ti molecular_function owl:Class
GO:0034473 biolink:NamedThing U1 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U1 snRNA molecule. got7fsn_ti U1 snRNA 3' end processing biological_process owl:Class
GO:0038097 biolink:NamedThing positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors. got7fsn_ti Fc epsilon RI-dependent mast cell activation|positive regulation of mast cell activation by Fc-epsilon receptor signalling pathway|Fc epsilon RI-mediated mast cell activation bf 2012-02-16T05:30:09Z biological_process owl:Class
GO:0009702 biolink:NamedThing L-arabinokinase activity Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+). got7fsn_ti ATP:L-arabinose 1-phosphotransferase activity|L-arabinokinase (phosphorylating) EC:2.7.1.46|RHEA:20153|MetaCyc:L-ARABINOKINASE-RXN|KEGG_REACTION:R01754 molecular_function owl:Class
GO:0070356 biolink:NamedThing synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a complex A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Rab3a (or orthologs thereof). got7fsn_ti SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2)|STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2 complex cellular_component owl:Class
GO:0072339 biolink:NamedThing cellular lactam biosynthetic process The chemical reactions and pathways resulting in the formation of lactams, any cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. got7fsn_ti cellular lactam synthesis|cellular lactam anabolism|cellular lactam biosynthesis|cellular lactam formation mah 2010-11-04T04:33:01Z biological_process owl:Class
GO:0150063 biolink:NamedThing visual system development The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways. got7fsn_ti visual pathway development|optic pathway development bc 2018-07-23T10:31:58Z biological_process owl:Class
GO:0099605 biolink:NamedThing regulation of action potential firing rate Any process that regulates the frequency of action potentials in a spike train. got7fsn_ti biological_process owl:Class
GO:0005760 biolink:NamedThing gamma DNA polymerase complex A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA. got7fsn_ti cellular_component owl:Class
GO:0050167 biolink:NamedThing pantothenoylcysteine decarboxylase activity Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO(2). got7fsn_ti N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase (pantetheine-forming)|N-[(R)-pantothenoyl]-L-cysteine carboxy-lyase activity|pantothenylcysteine decarboxylase activity|N-((R)-pantothenoyl)-L-cysteine carboxy-lyase activity EC:4.1.1.30|RHEA:15077|MetaCyc:PANTOTHENOYLCYSTEINE-DECARBOXYLASE-RXN|KEGG_REACTION:R02972 molecular_function owl:Class
GO:0002400 biolink:NamedThing tolerance induction in nasopharyngeal-associated lymphoid tissue Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT). got7fsn_ti tolerance induction in NALT|nasal tolerance biological_process owl:Class
GO:0101010 biolink:NamedThing pulmonary blood vessel remodeling The reorganization or renovation of existing pulmonary blood vessels. got7fsn_ti biological_process owl:Class
GO:0051306 biolink:NamedThing mitotic sister chromatid separation The process in which sister chromatids are physically detached from each other during mitosis. got7fsn_ti mitotic sister chromatid resolution|mitotic chromosome separation|sister chromatid separation during mitosis|chromosome separation during mitosis biological_process owl:Class
GO:0051304 biolink:NamedThing chromosome separation The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II). got7fsn_ti rDNA separation|chromatid release GO:0034500 biological_process owl:Class
GO:0051204 biolink:NamedThing protein insertion into mitochondrial membrane The process that results in the incorporation of a protein into a mitochondrial membrane. got7fsn_ti integral mitochondrial membrane protein positioning|positioning of protein in mitochondrial membrane|localization of protein in mitochondrial membrane|protein-mitochondrion membrane insertion|protein insertion into mitochondrion membrane|protein-mitochondrial membrane insertion|integral mitochondrial membrane protein localization https://github.com/geneontology/go-ontology/issues/15800 biological_process owl:Class
GO:0061329 biolink:NamedThing Malpighian tubule principal cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule principal cell. A Malpighian tubule principal cell is an epithelial secretory cell that transports cations into the lumen of the tubule. got7fsn_ti dph 2010-09-28T01:26:33Z biological_process owl:Class
GO:0003049 biolink:NamedThing regulation of systemic arterial blood pressure by capillary fluid shift The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment. got7fsn_ti blood pressure regulation by capillary fluid shift biological_process owl:Class
GO:0044378 biolink:NamedThing non-sequence-specific DNA binding, bending The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. got7fsn_ti DNA bending involving non-sequence-specific DNA binding jl 2011-12-08T02:02:13Z molecular_function owl:Class
GO:0090376 biolink:NamedThing seed trichome differentiation The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function. got7fsn_ti cotton fiber development|seed hair differentiation|seed trichome development tb 2010-09-15T02:07:10Z biological_process owl:Class
GO:0043240 biolink:NamedThing Fanconi anaemia nuclear complex A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. got7fsn_ti FA core complex|FA complex|Fanconi anaemia complex|FA nuclear complex cellular_component owl:Class
GO:0008030 biolink:NamedThing neuronal pentraxin receptor activity Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti neuronal pentaxin receptor molecular_function owl:Class
GO:0002792 biolink:NamedThing negative regulation of peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. got7fsn_ti down regulation of peptide secretion|down-regulation of peptide secretion|inhibition of peptide secretion|downregulation of peptide secretion biological_process owl:Class
GO:0008951 biolink:NamedThing palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]. got7fsn_ti palmitoleoyl ACP-dependent acyltransferase activity RHEA:44012|MetaCyc:PALMITOTRANS-RXN molecular_function owl:Class
GO:0045516 biolink:NamedThing interleukin-19 receptor binding Binding to an interleukin-19 receptor. got7fsn_ti IL-19|interleukin-19 receptor ligand molecular_function owl:Class
GO:0030340 biolink:NamedThing hyaluronate lyase activity Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. got7fsn_ti glucuronoglycosaminoglycan lyase activity|spreading factor activity|hyaluronidase activity|mucinase activity|hyaluronidase [but cf. EC:3.2.1.35 (hyalurononglucosaminidase) and EC:3.2.1.36 (hyaluronoglucuronidase)] EC:4.2.2.1|RHEA:50240|MetaCyc:HYALURONATE-LYASE-RXN molecular_function owl:Class
GO:0050552 biolink:NamedThing (4S)-limonene synthase activity Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate. got7fsn_ti (-)-(4S)-limonene synthase activity|geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-(4S)-limonene-forming]|geranyldiphosphate diphosphate lyase (limonene forming)|4S-(-)-limonene synthase activity|geranyldiphosphate diphosphate lyase [cyclizing, (4S)-limonene-forming] EC:4.2.3.16|MetaCyc:4.2.3.16-RXN|RHEA:12869 molecular_function owl:Class
GO:0010014 biolink:NamedThing meristem initiation Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue. got7fsn_ti biological_process owl:Class
GO:0018311 biolink:NamedThing peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine. got7fsn_ti peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine|peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine|peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine RESID:AA0236 biological_process owl:Class
GO:0006798 biolink:NamedThing polyphosphate catabolic process The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid. got7fsn_ti polyphosphate catabolism|polyphosphate degradation|polyphosphate breakdown biological_process owl:Class
GO:0005544 biolink:NamedThing calcium-dependent phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. got7fsn_ti molecular_function owl:Class
GO:0005543 biolink:NamedThing phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. got7fsn_ti molecular_function owl:Class
GO:0004516 biolink:NamedThing nicotinate phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate. got7fsn_ti nicotinic acid phosphoribosyltransferase activity|niacin ribonucleotidase activity|nicotinic acid mononucleotide pyrophosphorylase activity|nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity|nicotinic acid mononucleotide glycohydrolase activity Reactome:R-HSA-197186|RHEA:36163|EC:6.3.4.21|KEGG_REACTION:R01724|MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN molecular_function owl:Class
GO:0071770 biolink:NamedThing DIM/DIP cell wall layer assembly The aggregation, arrangement and bonding together of a set of components, including (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate and diphthioceranate, to form the DIM/DIP layer of the Actinobacterium-type cell wall. got7fsn_ti PDIM cell wall layer assembly|DIM cell wall layer assembly|DIM/DIP cell wall layer biogenesis mah 2010-03-29T04:47:19Z biological_process owl:Class
GO:0005476 biolink:NamedThing carnitine:acyl carnitine antiporter activity Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial). got7fsn_ti carnitine/acyl carnitine carrier activity|carnitine:acyl carnitine carrier activity|fatty acyl carnitine carrier molecular_function owl:Class
GO:0030731 biolink:NamedThing guanidinoacetate N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+). got7fsn_ti guanidinoacetate methyltransferase activity|GA methylpherase activity|methionine-guanidinoacetic transmethylase activity|guanidoacetate methyltransferase activity|guanidinoacetate transmethylase activity|S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity KEGG_REACTION:R01883|MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN|RHEA:10656|EC:2.1.1.2 molecular_function owl:Class
GO:1900556 biolink:NamedThing emericellamide catabolic process The chemical reactions and pathways resulting in the breakdown of emericellamide. got7fsn_ti emericellamide breakdown|emericellamide catabolism|emericellamide degradation di 2012-05-15T01:33:07Z biological_process owl:Class
GO:1900610 biolink:NamedThing F-9775A catabolic process The chemical reactions and pathways resulting in the breakdown of F-9775A. got7fsn_ti F-9775A degradation|F-9775A breakdown|F-9775A catabolism di 2012-05-15T07:02:49Z biological_process owl:Class
GO:0018503 biolink:NamedThing trans-1,2-dihydrodiolphenanthrene dehydrogenase activity Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene. got7fsn_ti UM-BBD_reactionID:r0574 molecular_function owl:Class
GO:0042863 biolink:NamedThing pyochelin metabolic process The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). got7fsn_ti pyochelin metabolism biological_process owl:Class
GO:0039509 biolink:NamedThing suppression by virus of host pattern recognition receptor activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. got7fsn_ti down-regulation by virus of host pattern recognition receptor activity|down regulation by virus of host pattern recognition receptor activity|viral inhibition of host pattern recognition receptor activity|negative regulation by virus of host pattern recognition receptor activity|suppression by virus of host pattern recognition receptor function|inhibition by virus of host pattern recognition receptor activity bf 2011-06-02T03:11:23Z biological_process owl:Class
GO:0039508 biolink:NamedThing suppression by virus of host receptor activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor. got7fsn_ti down-regulation by virus of host receptor activity|inhibition by virus of host receptor activity|viral inhibition of host receptor|downregulation by virus of host receptor activity|negative regulation by virus of host receptor activity|suppression by virus of host receptor function bf 2011-06-02T03:09:37Z biological_process owl:Class
GO:0046989 biolink:NamedThing galactosyl beta-1,3 N-acetylgalactosamine beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to the disaccharide galactosyl beta-1,3 N-acetylgalactosamine, a common component of glycoproteins and glycolipids. got7fsn_ti molecular_function owl:Class
GO:0034366 biolink:NamedThing spherical high-density lipoprotein particle A mature high-density lipoprotein (HDL) particle, converted from discoidal HDL particles following the esterification of cholesterol in the particle by phosphatidylcholine-sterol O-acyltransferase (lecithin cholesterol acyltransferase; LCAT). got7fsn_ti mature HDL|spherical HDL|mature high-density lipoprotein particle cellular_component owl:Class
GO:0035797 biolink:NamedThing tellurite methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride). got7fsn_ti tellurite methylase activity|SAM-dependent tellurite methyltransferase activity|S-adenosyl-L-methionine-dependent tellurite methyltransferase activity bf 2011-04-14T01:06:19Z molecular_function owl:Class
GO:0000139 biolink:NamedThing Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. got7fsn_ti cellular_component owl:Class
GO:0070714 biolink:NamedThing RNA guanosine-uridine insertion The modification of an RNA molecule by insertion of an guanosine-uridine insertion dinucleotide. got7fsn_ti RNA GU insertion mah 2009-06-08T05:33:20Z biological_process owl:Class
GO:0043616 biolink:NamedThing keratinocyte proliferation The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. got7fsn_ti biological_process owl:Class
GO:0120133 biolink:NamedThing negative regulation of actin cortical patch assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin cortical patches. got7fsn_ti downregulation of actin cortical patch assembly|inhibition of actin cortical patch assembly|down-regulation of actin cortical patch assembly|down regulation of actin cortical patch assembly krc 2018-02-20T16:23:53Z biological_process owl:Class
GO:0047031 biolink:NamedThing diethyl 2-methyl-3-oxosuccinate reductase activity Catalysis of the reaction: diethyl (2R,3R)-2-methyl-3-hydroxysuccinate + NADP(+) = diethyl 2-methyl-3-oxosuccinate + H(+) + NADPH. got7fsn_ti diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP+ 3-oxidoreductase activity EC:1.1.1.229|RHEA:21008|KEGG_REACTION:R04387|MetaCyc:1.1.1.229-RXN molecular_function owl:Class
GO:0061595 biolink:NamedThing 6-deoxy-6-sulfofructose-1-phosphate aldolase activity Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate. got7fsn_ti dph 2014-02-10T10:05:27Z molecular_function owl:Class
GO:0102122 biolink:NamedThing gibberellin A34 carboxyl methyltransferase activity Catalysis of the reaction: gibberellin A34 + S-adenosyl-L-methionine = gibberellin A34 methyl ester + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:36127|MetaCyc:RXN-11384 molecular_function owl:Class
GO:0031733 biolink:NamedThing CCR8 chemokine receptor binding Binding to a CCR8 chemokine receptor. got7fsn_ti CCR8 chemokine receptor ligand molecular_function owl:Class
GO:0045050 biolink:NamedThing protein insertion into ER membrane by stop-transfer membrane-anchor sequence A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix. got7fsn_ti protein-ER insertion by stop-transfer membrane-anchor sequence|protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated|protein-endoplasmic reticulum insertion by stop-transfer membrane-anchor sequence|protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence|stop-transfer membrane-anchor sequence mediated protein insertion into ER membrane biological_process owl:Class
GO:0097542 biolink:NamedThing ciliary tip Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. got7fsn_ti cilial tip|flagellum tip|cilium tip|flagellar tip Note that cilia and eukaryotic flagella are deemed to be equivalent. pr 2013-12-12T11:12:22Z cellular_component owl:Class
GO:1990955 biolink:NamedThing G-rich single-stranded DNA binding Binding to G-rich, single-stranded DNA. got7fsn_ti hjd 2016-05-13T17:44:28Z molecular_function owl:Class
GO:0102219 biolink:NamedThing phosphogluco-amylopectin water dikinase activity Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-amylopectin = n AMP + n hydrogenphosphate + a 6-phosphogluco-3-phosphogluco-amylopectin. got7fsn_ti EC:2.7.9.5|MetaCyc:RXN-12204 molecular_function owl:Class
GO:0051752 biolink:NamedThing phosphoglucan, water dikinase activity Catalysis of the reaction: ATP + [phospho-alpha-glucan] + H2O = AMP + O-phospho-[phospho-alpha-glucan] + phosphate. got7fsn_ti ATP:phospho-alpha-glucan, water phosphotransferase activity|OK1|PWD EC:2.7.9.5|MetaCyc:2.7.9.5-RXN molecular_function owl:Class
GO:0140592 biolink:NamedThing histone methyltransferase activity (H3-R8 specific) Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 8) = S-adenosyl-L-homocysteine + (histone H3-N-methyl-arginine (position 8). This reaction is the addition of a methyl group to arginine at position 8 of histone H3. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20037 pg 2021-02-09T14:13:17Z molecular_function owl:Class
GO:1902555 biolink:NamedThing endoribonuclease complex A protein complex which is capable of endoribonuclease activity. got7fsn_ti Ire1 complex dimer|Ire1 complex homodimer|Ire1 complex homooligomer An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay). bhm 2013-12-06T16:09:31Z cellular_component owl:Class
GO:0046404 biolink:NamedThing polydeoxyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. got7fsn_ti ATP-dependent DNA kinase activity|ATP:5'-dephosphopolydeoxyribonucleotide 5'-phosphotransferase activity|ATP-dependent polynucleotide 5'-hydroxyl-kinase activity|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent DNA 5'-hydroxyl-kinase activity https://github.com/geneontology/go-ontology/issues/21619 KEGG_REACTION:R03840|MetaCyc:POLYNUCLEOTIDE-5-HYDROXYL-KINASE-RXN|EC:2.7.1.78|RHEA:15669 molecular_function owl:Class
GO:0008661 biolink:NamedThing 1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2). got7fsn_ti pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)|DXP-synthase activity|DOXP synthase activity|1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity|1-deoxyxylulose-5-phosphate synthase activity RHEA:12605|MetaCyc:DXS-RXN|KEGG_REACTION:R05636|EC:2.2.1.7 molecular_function owl:Class
GO:0047443 biolink:NamedThing 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity Catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate. got7fsn_ti gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity|4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)|pyruvate aldolase activity|4-hydroxy-4-methyl-2-ketoglutarate aldolase activity|4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase activity EC:4.1.3.17|MetaCyc:4.1.3.17-RXN|RHEA:22748 molecular_function owl:Class
GO:0010739 biolink:NamedThing positive regulation of protein kinase A signaling Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. got7fsn_ti positive regulation of protein kinase A signalling cascade|positive regulation of protein kinase A signaling cascade|positive regulation of PKA signaling cascade biological_process owl:Class
GO:0051896 biolink:NamedThing regulation of protein kinase B signaling Any process that modulates the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. got7fsn_ti regulation of protein kinase B signalling cascade|regulation of PKB signalling cascade|regulation of PKB signaling cascade|regulation of AKT signalling cascade|regulation of protein kinase B signaling cascade|regulation of AKT signaling cascade biological_process owl:Class
GO:0103098 biolink:NamedThing CYP79F1 tetrahomomethionine monooxygenase activity Catalysis of the reaction: 2 H+ + tetrahomomethionine + 2 O2 + 2 NADPH <=> 3 H2O + carbon dioxide + 2 NADP + 7-methylthioheptanaldoxime. got7fsn_ti MetaCyc:RXNQT-4311 molecular_function owl:Class
GO:0034890 biolink:NamedThing endosulfan diol hydrolyase (cyclizing) activity Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O. got7fsn_ti UM-BBD_reactionID:r1386 molecular_function owl:Class
GO:0043463 biolink:NamedThing regulation of rhamnose catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose. got7fsn_ti regulation of rhamnose breakdown|regulation of rhamnose catabolism|regulation of rhamnose degradation biological_process owl:Class
GO:0033965 biolink:NamedThing aculeacin-A deacylase activity Catalysis of the hydrolysis of the amide bond in aculeacin A and related neutral lipopeptide antibiotics, releasing the long-chain fatty acid side-chain. got7fsn_ti aculeacin A acylase activity|aculeacin-A amidohydrolase activity MetaCyc:3.5.1.70-RXN|EC:3.5.1.70 molecular_function owl:Class
GO:0006719 biolink:NamedThing juvenile hormone catabolic process The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. got7fsn_ti juvenile hormone catabolism|juvenile hormone breakdown|juvenile hormone degradation biological_process owl:Class
GO:0044346 biolink:NamedThing fibroblast apoptotic process Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti fibroblast apoptosis jl 2010-09-23T11:33:38Z biological_process owl:Class
GO:0071037 biolink:NamedThing nuclear polyadenylation-dependent snRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a small nuclear RNA (snRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target snRNA. got7fsn_ti nuclear poly(A)-dependent snRNA catabolic process krc 2009-07-29T01:07:18Z biological_process owl:Class
GO:0016076 biolink:NamedThing snRNA catabolic process The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. got7fsn_ti snRNA catabolism|snRNA degradation|snRNA breakdown biological_process owl:Class
GO:0032945 biolink:NamedThing negative regulation of mononuclear cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation. got7fsn_ti negative regulation of PBMC proliferation|negative regulation of peripheral blood mononuclear cell proliferation biological_process owl:Class
GO:0031254 biolink:NamedThing cell trailing edge The area of a motile cell opposite to the direction of movement. got7fsn_ti trailing edge|back of cell cellular_component owl:Class
GO:0051043 biolink:NamedThing regulation of membrane protein ectodomain proteolysis Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). got7fsn_ti biological_process owl:Class
GO:0071163 biolink:NamedThing DNA replication preinitiation complex assembly The aggregation, arrangement and bonding together of a set of components to form the DNA replication preinitiation complex, a protein-DNA complex that is assembled at DNA replication origins immediately prior to the initiation of DNA replication. The complex consists of proteins that initiate the DNA binding, melt the helix and enable helicase activity. got7fsn_ti pre-IC complex assembly|DNA replication preinitiation complex formation mah 2009-11-19T11:13:41Z GO:1902293|GO:1902316 biological_process owl:Class
GO:0071096 biolink:NamedThing alphaV-beta3 integrin-gelsolin complex A protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin. got7fsn_ti ITGAV-ITGB3-Gsn complex mah 2009-11-06T04:49:31Z cellular_component owl:Class
GO:0030046 biolink:NamedThing parallel actin filament bundle assembly Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity. got7fsn_ti biological_process owl:Class
GO:0102988 biolink:NamedThing 9,12-cis-hexadecadienoic acid delta 15 desaturase activity Catalysis of the reaction: (9Z,12Z)-hexadecadienoyl-CoA + O2 + a reduced electron acceptor <=> 9,12,15-cis-hexadecatrienoyl-CoA + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-9617|RHEA:46232 molecular_function owl:Class
GO:0052687 biolink:NamedThing (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP + phosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA. got7fsn_ti 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity KEGG_REACTION:R06396 molecular_function owl:Class
GO:0047311 biolink:NamedThing 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol transaminase activity Catalysis of the reaction: 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol + pyruvate = 1D-1-guanidino-1-deoxy-3-dehydro-scyllo-inositol + L-alanine. got7fsn_ti 1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol aminotransferase activity|1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol:pyruvate aminotransferase activity|L-alanine-N-amidino-3-(or 5-)keto-scyllo-inosamine transaminase activity|guanidinoaminodideoxy-scyllo-inositol-pyruvate aminotransferase activity EC:2.6.1.56|KEGG_REACTION:R03502|MetaCyc:2.6.1.56-RXN|RHEA:15497 molecular_function owl:Class
GO:0000049 biolink:NamedThing tRNA binding Binding to a transfer RNA. got7fsn_ti base pairing with tRNA GO:0000946 molecular_function owl:Class
GO:0034365 biolink:NamedThing discoidal high-density lipoprotein particle A newly formed high-density lipoprotein particle; consists of a phospholipid bilayer surrounded by two or more APOA1 molecules. The discoidal HDL particle is formed when lipid-free or lipid-poor APOA1 acquires phospholipids and unesterified cholesterol from either cell membranes or triglyceride-rich lipoproteins (undergoing lipolysis by lipoprotein lipase). got7fsn_ti discoidal HDL|nascent high-density lipoprotein particle|nascent HDL cellular_component owl:Class
GO:0034823 biolink:NamedThing citronellyl-CoA ligase activity Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi. got7fsn_ti KEGG_REACTION:R08088|UM-BBD_reactionID:r1157 molecular_function owl:Class
GO:0019703 biolink:NamedThing coenzyme A-peptidyl-cysteine covalent linking The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide. got7fsn_ti RESID:AA0306 biological_process owl:Class
GO:0036157 biolink:NamedThing outer dynein arm Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. got7fsn_ti outer dynein arm complex bf 2012-03-21T01:25:03Z cellular_component owl:Class
GO:0047855 biolink:NamedThing dihydrobunolol dehydrogenase activity Catalysis of the reaction: dihydrobunolol + NADP(+) = bunolol + H(+) + NADPH. got7fsn_ti bunolol reductase activity|(+-)-5-[(tert-butylamino)-2'-hydroxypropoxy]-1,2,3,4-tetrahydro-1-naphthol:NADP+ oxidoreductase activity RHEA:15925|MetaCyc:DIHYDROBUNOLOL-DEHYDROGENASE-RXN|EC:1.1.1.160|KEGG_REACTION:R04623 molecular_function owl:Class
GO:0072452 biolink:NamedThing response to G2 transition size control checkpoint signaling A process that occurs in response to signals generated as a result of G2/M transition size control checkpoint signaling. got7fsn_ti response to G2/M transition size control checkpoint signaling|response to mitotic cell cycle G2/M transition size control checkpoint signaling|response to signal involved in G2/M transition size control checkpoint|G2/M transition size control checkpoint effector process mah 2010-12-09T11:14:12Z biological_process owl:Class
GO:0047988 biolink:NamedThing hydroxyacid-oxoacid transhydrogenase activity Catalysis of the reaction: (S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate. got7fsn_ti transhydrogenase, hydroxy acid-oxo acid|(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase activity Reactome:R-HSA-880033|Reactome:R-HSA-880002|EC:1.1.99.24|MetaCyc:HYDROXYACID-OXOACID-TRANSHYDROGENASE-RXN molecular_function owl:Class
GO:0004756 biolink:NamedThing selenide, water dikinase activity Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate. got7fsn_ti ATP:selenide, water phosphotransferase activity|selenium donor protein activity|selenophosphate synthase activity|selenide,water dikinase activity|selenophosphate synthetase activity KEGG_REACTION:R03595|EC:2.7.9.3|RHEA:18737|MetaCyc:2.7.9.3-RXN|Reactome:R-HSA-8959510|UM-BBD_reactionID:r0833 molecular_function owl:Class
GO:0050699 biolink:NamedThing WW domain binding Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. got7fsn_ti molecular_function owl:Class
GO:0051879 biolink:NamedThing Hsp90 protein binding Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. got7fsn_ti Hsp90 binding|Hsp90 class protein binding molecular_function owl:Class
GO:2000860 biolink:NamedThing positive regulation of aldosterone secretion Any process that activates or increases the frequency, rate or extent of aldosterone secretion. got7fsn_ti bf 2011-07-26T08:47:34Z biological_process owl:Class
GO:0060035 biolink:NamedThing notochord cell development The process whose specific outcome is the progression of a notochord cell over time, from its formation to its mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0005035 biolink:NamedThing death receptor activity Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. got7fsn_ti apoptosis-activating receptor activity molecular_function owl:Class
GO:0002365 biolink:NamedThing gamma-delta T cell lineage commitment The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell. got7fsn_ti gamma-delta T lymphocyte lineage commitment|gamma-delta T-cell lineage commitment|gamma-delta T-lymphocyte lineage commitment biological_process owl:Class
GO:0018674 biolink:NamedThing (S)-limonene 3-monooxygenase activity Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+). got7fsn_ti (-)-limonene 3-hydroxylase activity|(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity|(-)-limonene 3-monooxygenase activity|limonene 3-hydroxylase activity|(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) EC:1.14.14.99|MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN|UM-BBD_reactionID:r0739|KEGG_REACTION:R02469|RHEA:15129 molecular_function owl:Class
GO:0016212 biolink:NamedThing kynurenine-oxoglutarate transaminase activity Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. got7fsn_ti kynurenine-oxoglutarate aminotransferase activity|L-kynurenine:2-oxoglutarate aminotransferase activity|kynurenine transaminase (cyclizing)|kynurenine 2-oxoglutarate transaminase activity|kynurenine--oxoglutarate aminotransferase activity|kynurenine aminotransferase activity|L-kynurenine aminotransferase activity MetaCyc:2.6.1.7-RXN|RHEA:20964|Reactome:R-HSA-901097|Reactome:R-HSA-893583|Reactome:R-HSA-893596|EC:2.6.1.7 molecular_function owl:Class
GO:0071965 biolink:NamedThing multicellular organismal locomotion Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another. got7fsn_ti mah 2010-10-14T10:34:35Z biological_process owl:Class
GO:0038180 biolink:NamedThing nerve growth factor signaling pathway A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti NGF signaling pathway|nerve growth factor signalling pathway Nerve growth factor (NGF) binds at least two classes of receptors: the p75 LNGFR (low-affinity nerve growth factor receptor) and TrkA, a transmembrane tyrosine kinase. bf 2013-05-15T11:04:05Z Wikipedia:Nerve_growth_factor biological_process owl:Class
GO:0051431 biolink:NamedThing corticotropin-releasing hormone receptor 2 binding Binding to a corticotropin-releasing hormone receptor type 2 (CRHR2). The CRHR2 has several splice variants that are located in sub-cortical areas of the brain and in the periphery. got7fsn_ti type 2 corticotropin releasing factor receptor binding|CRHR2 binding|type 2 corticotropin releasing factor receptor ligand|type 2 corticotropin-releasing factor receptor binding GO:0031744 molecular_function owl:Class
GO:1900032 biolink:NamedThing regulation of trichome patterning Any process that modulates the frequency, rate or extent of trichome patterning. got7fsn_ti regulation of trichome pattern formation|regulation of trichome spacing|regulation of trichome pattern specification|regulation of trichome pattern biosynthesis|regulation of trichome distribution tb 2012-01-13T11:10:46Z biological_process owl:Class
GO:0010423 biolink:NamedThing negative regulation of brassinosteroid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids. got7fsn_ti biological_process owl:Class
GO:0052642 biolink:NamedThing lysophosphatidic acid phosphatase activity Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol. got7fsn_ti lysophosphatidate phosphatase activity|LPA phosphatase activity Reactome:R-HSA-8878654 molecular_function owl:Class
GO:0097010 biolink:NamedThing eukaryotic translation initiation factor 4F complex assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex. got7fsn_ti eIF-4F assembly|eIF4F assembly pr 2011-03-21T04:19:26Z biological_process owl:Class
GO:0102923 biolink:NamedThing 3'-N-debenzoyl-2'-deoxytaxol N-benzoyltransferase activity Catalysis of the reaction: 3'-N-debenzoyltaxol + benzoyl-CoA = H+ + paclitaxel + coenzyme A. got7fsn_ti MetaCyc:RXN-8859|RHEA:33687 molecular_function owl:Class
GO:0150103 biolink:NamedThing reactive gliosis A neuroinflammatory response, occurring over several days, during which glial cells undergo nonspecific reactive changes in response to damage to the central nervous system (CNS); typically involves the proliferation or hypertrophy of different types of glial cells. got7fsn_ti gliosis bc 2019-05-21T12:37:31Z biological_process owl:Class
GO:0046524 biolink:NamedThing sucrose-phosphate synthase activity Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. got7fsn_ti UDPglucose-fructose-phosphate glucosyltransferase activity|sucrose phosphate-uridine diphosphate glucosyltransferase activity|UDP-glucose-fructose-phosphate glucosyltransferase activity|SPS|UDP-glucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity|sucrosephosphate-UDP glucosyltransferase activity|sucrose phosphate synthetase activity|uridine diphosphoglucose-fructose phosphate glucosyltransferase activity|UDPglucose:D-fructose-6-phosphate 2-alpha-D-glucosyltransferase activity|sucrose 6-phosphate synthase activity MetaCyc:SUCROSE-PHOSPHATE-SYNTHASE-RXN|RHEA:22172|EC:2.4.1.14 molecular_function owl:Class
GO:0070332 biolink:NamedThing CD20-Lck-Lyn-Fyn complex A protein complex that contains the cell-surface protein CD20 and the Src family tyrosine kinases Lck, Lyn and Fyn. got7fsn_ti cellular_component owl:Class
GO:0004190 biolink:NamedThing aspartic-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. got7fsn_ti aspartic endopeptidase activity|aspartyl protease activity|aspartic protease activity|aspartate protease activity|carboxyl protease activity EC:3.4.23.43|MetaCyc:3.4.23.36-RXN|MetaCyc:3.4.23.25-RXN|MetaCyc:3.4.23.32-RXN|MetaCyc:3.4.23.34-RXN|MetaCyc:3.4.23.43-RXN|EC:3.4.23.25|Reactome:R-HSA-157640|Reactome:R-HSA-2065357|EC:3.4.23.34|EC:3.4.23.15|EC:3.4.23.20|EC:3.4.23.1|Reactome:R-HSA-9017817|Reactome:R-HSA-2022403|MetaCyc:3.4.23.4-RXN|MetaCyc:3.4.23.15-RXN|Reactome:R-HSA-9013361|EC:3.4.23.35|Reactome:R-HSA-373705|MetaCyc:3.4.23.20-RXN|Reactome:R-HSA-2022412|EC:3.4.23.-|MetaCyc:3.4.23.5-RXN|EC:3.4.23.5|EC:3.4.23.36|MetaCyc:3.4.23.35-RXN|Reactome:R-HSA-2220988|Reactome:R-HSA-157353|EC:3.4.23.4|EC:3.4.23.32|Reactome:R-HSA-9604294|MetaCyc:3.4.23.1-RXN molecular_function owl:Class
GO:0047275 biolink:NamedThing glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = D-galactosyl-N-acetyl-D-glucosaminyl-(1,3)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. got7fsn_ti UDP-galactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity|UDPgalactose:N-acetyl-D-glucosaminyl-1,3-D-galactosyl-1,4-D-glucosylceramide beta-D-galactosyltransferase activity|paragloboside synthase activity|GalT-4|uridine diphosphogalactose-acetyl-glucosaminylgalactosylglucosylceramide galactosyltransferase activity MetaCyc:2.4.1.86-RXN|EC:2.4.1.86|RHEA:16045 molecular_function owl:Class
GO:0008830 biolink:NamedThing dTDP-4-dehydrorhamnose 3,5-epimerase activity Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose. got7fsn_ti thymidine diphospho-4-ketorhamnose 3,5-epimerase activity|dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity|dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity|TDP-4-ketorhamnose 3,5-epimerase activity|TDP-4-keto-L-rhamnose-3,5-epimerase activity RHEA:16969|MetaCyc:DTDPDEHYDRHAMEPIM-RXN|KEGG_REACTION:R06514|EC:5.1.3.13 molecular_function owl:Class
GO:0102098 biolink:NamedThing D-galacturonate reductase activity Catalysis of the reaction: L-galactonate + NADP = aldehydo-D-galacturonate + NADPH + H+. got7fsn_ti RHEA:26345|MetaCyc:RXN-11151|EC:1.1.1.365 molecular_function owl:Class
GO:0061807 biolink:NamedThing positive regulation of DNA recombination at centromere Any process that activates or increases the frequency, rate or extent of DNA recombination at the centromere. got7fsn_ti positive regulation of centromeric recombination dph 2016-11-10T15:20:04Z biological_process owl:Class
GO:0052084 biolink:NamedThing modulation by symbiont of host ethylene-mediated defense response Any process in which a symbiont modulates the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction|modulation by symbiont of defense-related host ethylene-mediated signal transduction pathway|modulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction GO:0052279|GO:0052441|GO:0052077 biological_process owl:Class
GO:0008930 biolink:NamedThing methylthioadenosine nucleosidase activity Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose. got7fsn_ti MTA nucleosidase activity|MeSAdo nucleosidase activity|S-methyl-5'-thioadenosine adeninehyrolase activity|5'-methylthioadenosine nucleosidase activity|methylthioadenosine methylthioribohydrolase activity EC:3.2.2.16|RHEA:13617|MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN molecular_function owl:Class
GO:0120100 biolink:NamedThing bacterial-type flagellum motor A transmembrane complex embedded in the cytoplasmic membrane which is the motor force, or torque, generator of the bacterial-type flagellum. The motor consists of a membrane-anchored rotor complex surrounded by one or more stator complexes in the cytoplasmic membrane. The stator consists of a hetero-hexameric complex of 2 membrane proteins, A and B, with stoichiometry A4B2. Examples are the H+ driven MotA-MotB stator complex of Escherichia coli and Salmonella enterica, and the Na+ driven PomA-PomB stator complex of Vibrio and Shewanella species. The rotor complex consists of a membrane-anchored ring and the motor switch complex, which controls the direction of flagellar rotation. got7fsn_ti krc 2017-10-03T15:44:35Z cellular_component owl:Class
GO:0050566 biolink:NamedThing asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP. got7fsn_ti Asp-tRNA(Asn) amidotransferase activity|Asp-tRNAAsn:L-glutamine amido-ligase (ADP-forming)|asparaginyl-tRNA synthase (glutamine-hydrolysing)|Asp-tRNAAsn amidotransferase activity|aspartyl-tRNAAsn amidotransferase activity|Asp-AdT activity|aspartyl-tRNAAsn:L-glutamine amido-ligase (ADP-forming)|aspartyl-tRNA(Asn) amidotransferase activity EC:6.3.5.6|Wikipedia:Asparaginyl-tRNA_synthase_(glutamine-hydrolysing)|MetaCyc:6.3.5.6-RXN|RHEA:14513 molecular_function owl:Class
GO:0075029 biolink:NamedThing formation of appressorium germ tube hook structure The development of a swollen tip at the growing end of a symbiont spore which usually flattens against the host cell surface prior to appressorium formation. got7fsn_ti formation of germ tube tip of symbiont on or near the exterior of host|formation of symbiont germ tube hook structure for appressorium development|symbiont germ tube hook structure formation on or near host|formation of symbiont germ tube hook structure on or near host biological_process owl:Class
GO:0043701 biolink:NamedThing cyanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance. got7fsn_ti cellular_component owl:Class
GO:0047814 biolink:NamedThing D-arabinokinase activity Catalysis of the reaction: D-arabinose + ATP = D-arabinose 5-phosphate + ADP. got7fsn_ti D-arabinokinase (phosphorylating)|ATP:D-arabinose 5-phosphotransferase activity RHEA:24588|MetaCyc:D-ARABINOKINASE-RXN|EC:2.7.1.54|KEGG_REACTION:R01573 molecular_function owl:Class
GO:0035571 biolink:NamedThing N-terminal peptidyl-serine monomethylation The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine. got7fsn_ti bf 2010-08-06T01:58:56Z biological_process owl:Class
GO:0052676 biolink:NamedThing 3-methylbutanol:NAD oxidoreductase activity Catalysis of the reaction: 3-methylbutanol + NAD+ = 3-methylbutanal + NADH + H+. 3-methylbutanal is also known as isovaleraldehyde. got7fsn_ti 3-methylbutanal reductase (NAD) activity|3-methylbutyraldehyde reductase (NAD) activity|isoamyl alcohol oxidase (NAD) activity|3-methylbutanol:NAD+ oxidoreductase activity ai 2011-04-12T11:22:42Z KEGG_REACTION:R05685|RHEA:18529 molecular_function owl:Class
GO:0010184 biolink:NamedThing cytokinin transport The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0019096 biolink:NamedThing pole plasm mitochondrial lrRNA localization Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. got7fsn_ti pole plasm mitochondrial lrRNA localisation|establishment and maintenance of mitochondrial lrRNA localization in pole plasm|oocyte pole plasm mitochondrial lrRNA localization GO:0048118 biological_process owl:Class
GO:0019355 biolink:NamedThing nicotinamide nucleotide biosynthetic process from aspartate The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate. got7fsn_ti nicotinamide nucleotide formation from aspartate|nicotinamide nucleotide synthesis from aspartate|nicotinamide nucleotide anabolism from aspartate biological_process owl:Class
GO:0043695 biolink:NamedThing detection of pheromone The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0005592 biolink:NamedThing collagen type XI trimer A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils. got7fsn_ti cellular_component owl:Class
GO:0047438 biolink:NamedThing 2-dehydro-3-deoxy-L-pentonate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-L-pentonate = glycolaldehyde + pyruvate. got7fsn_ti 3-deoxy-D-pentulosonic acid aldolase|2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase (pyruvate-forming)|2-keto-3-deoxy-D-xylonate aldolase activity|2-dehydro-3-deoxy-L-pentonate glycolaldehyde-lyase activity|2-keto-3-deoxy-L-arabonate aldolase activity|2-keto-3-deoxy-L-pentonate aldolase activity RHEA:18545|MetaCyc:4.1.2.18-RXN|EC:4.1.2.18 molecular_function owl:Class
GO:0015324 biolink:NamedThing peptide-acetyl-CoA secondary active transmembrane transporter activity Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti peptide-acetyl-CoA transporter activity molecular_function owl:Class
GO:0022000 biolink:NamedThing forebrain induction by the anterior neural ridge The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate. got7fsn_ti biological_process owl:Class
GO:0042464 biolink:NamedThing dosage compensation by hypoactivation of X chromosome Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans. got7fsn_ti biological_process owl:Class
GO:0085020 biolink:NamedThing protein K6-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair. got7fsn_ti protein K6-linked polyubiquitination jl 2010-06-01T03:05:03Z biological_process owl:Class
GO:0106099 biolink:NamedThing 2-keto-3-deoxy-L-rhamnonate aldolase activity Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde. got7fsn_ti hjd 2018-02-15T16:12:17Z RHEA:25784|EC:4.1.2.53 molecular_function owl:Class
GO:0033849 biolink:NamedThing chrysanthemyl diphosphate synthase activity Catalysis of the reaction: 2 dimethylallyl diphosphate = (R,R)-chrysanthemyl diphosphate + diphosphate. got7fsn_ti dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming) activity|CPPase activity KEGG_REACTION:R08948|RHEA:14009|MetaCyc:2.5.1.67-RXN|EC:2.5.1.67 molecular_function owl:Class
GO:0102652 biolink:NamedThing gibberellin A9,2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A9 + 2-oxoglutarate + O2 <=> gibberellin A51 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-171 molecular_function owl:Class
GO:0044601 biolink:NamedThing protein denucleotidylation The removal of a nucleotide from a protein amino acid. got7fsn_ti jl 2012-05-01T04:13:54Z biological_process owl:Class
GO:0102039 biolink:NamedThing alkylhydroperoxide reductase activity Catalysis of the reaction: H2O + NAD + an alcohol <=> NADH + H+ + an organic hydroperoxide. got7fsn_ti EC:1.11.1.26|MetaCyc:R4-RXN molecular_function owl:Class
GO:0060929 biolink:NamedThing atrioventricular node cell fate commitment The commitment of cells to atrioventricular (AV) node cell fates and their capacity to differentiate into AV node cells. got7fsn_ti AV node cell fate commitment dph 2009-09-29T12:01:24Z biological_process owl:Class
GO:0008523 biolink:NamedThing sodium-dependent multivitamin transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate. got7fsn_ti Reactome:R-HSA-429581|Reactome:R-HSA-199206|Reactome:R-HSA-199219 molecular_function owl:Class
GO:0007191 biolink:NamedThing adenylate cyclase-activating dopamine receptor signaling pathway The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). got7fsn_ti dopamine receptor, adenylyl cyclase activating pathway|activation of adenylate cyclase activity by dopamine receptor signalling pathway|activation of adenylate cyclase activity by dopamine receptor signaling pathway|dopamine receptor, adenylate cyclase activating pathway biological_process owl:Class
GO:0022818 biolink:NamedThing sodium ion uniporter activity Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. got7fsn_ti molecular_function owl:Class
GO:0062201 biolink:NamedThing actin wave A cellular anatomical entity that is part of the actin cytoskeleton and results in a wave-like propagation of actin networks. It consists of dynamic structures traveling on the ventral (substrate-attached) side of the cell during cell migration, cytokinesis, adhesion and neurogenesis. got7fsn_ti dph 2020-01-02T13:45:03Z cellular_component owl:Class
GO:0036383 biolink:NamedThing 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O. got7fsn_ti bf 2013-05-23T11:31:09Z MetaCyc:1.14.14.12-RXN|EC:1.14.14.12|KEGG_REACTION:R09819|RHEA:31731 molecular_function owl:Class
GO:0004968 biolink:NamedThing gonadotropin-releasing hormone receptor activity Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. got7fsn_ti GnRH receptor activity|gonadotrophin-releasing hormone receptor activity molecular_function owl:Class
GO:0097219 biolink:NamedThing compound sieve plate A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement. got7fsn_ti Often located on an end wall of a sieve tube member. Unspecialized sieve areas may occur on other parts of the cell. pr 2012-01-13T05:45:23Z cellular_component owl:Class
GO:0034709 biolink:NamedThing methylosome A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. got7fsn_ti 20S methyltransferase complex|20S methylosome cellular_component owl:Class
GO:0004963 biolink:NamedThing follicle-stimulating hormone receptor activity Combining with follicle-stimulating hormone to initiate a change in cell activity. got7fsn_ti FSH receptor activity|follicle stimulating hormone receptor activity molecular_function owl:Class
GO:0072043 biolink:NamedThing regulation of pre-tubular aggregate formation by cell-cell signaling Any process that mediates the transfer of information from one cell to another that modulates the rate, frequency, or extent of pre-tubular aggregate formation. Pre-tubular aggregate formation is the cell adhesion process in which mesenchymal cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney. got7fsn_ti regulation of pre-tubular aggregate formation by cell-cell signalling mah 2010-01-25T03:12:03Z biological_process owl:Class
GO:0035191 biolink:NamedThing nuclear axial expansion The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex. got7fsn_ti nuclear distribution along anterior-posterior axis|nucleus distribution along anterior-posterior axis biological_process owl:Class
GO:0051481 biolink:NamedThing negative regulation of cytosolic calcium ion concentration Any process that decreases the concentration of calcium ions in the cytosol. got7fsn_ti reduction of calcium ion concentration in cytosol|cytoplasmic calcium ion concentration reduction|cytosolic calcium ion concentration reduction|reduction of calcium ion concentration in cytoplasm|reduction of cytosolic calcium ion concentration|reduction of cytoplasmic calcium ion concentration biological_process owl:Class
GO:0000907 biolink:NamedThing sulfonate dioxygenase activity Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2. got7fsn_ti sulphonate dioxygenase activity|sulfonate/alpha-ketoglutarate dioxygenase activity molecular_function owl:Class
GO:0039648 biolink:NamedThing modulation by virus of host protein ubiquitination Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein. got7fsn_ti modulation of host ubiquitin pathway by virus bf 2012-10-09T15:20:47Z biological_process owl:Class
GO:0007629 biolink:NamedThing flight behavior The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air. got7fsn_ti flight behaviour biological_process owl:Class
GO:0014827 biolink:NamedThing intestine smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine. got7fsn_ti biological_process owl:Class
GO:0000822 biolink:NamedThing inositol hexakisphosphate binding Binding to inositol hexakisphosphate. got7fsn_ti IP6 binding|InsP6 binding molecular_function owl:Class
GO:0015928 biolink:NamedThing fucosidase activity Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative. got7fsn_ti molecular_function owl:Class
GO:0031910 biolink:NamedThing cytostome Stable, specialized structure for the ingestion of food by the cell into phagosomes. got7fsn_ti Wikipedia:Cytostome cellular_component owl:Class
GO:0033799 biolink:NamedThing myricetin 3'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + myricetin = S-adenosyl-L-homocysteine + laricitrin. got7fsn_ti S-adenosyl-L-methionine:myricetin O-methyltransferase activity|myricetin 3-O-methyltransferase activity|CrCOMT2|flavonoid 3',5'-O-dimethyltransferase activity Note that this term represents one of two reactions that are grouped together in EC:2.1.1.267 GO:0102437 EC:2.1.1.267;|MetaCyc:RXN-8451|KEGG_REACTION:R06815|MetaCyc:RXN-13912|RHEA:25629 molecular_function owl:Class
GO:0004017 biolink:NamedThing adenylate kinase activity Catalysis of the reaction: ATP + AMP = 2 ADP. got7fsn_ti myokinase activity|adenylokinase activity|adenylic kinase activity|ATP:AMP phosphotransferase activity|5'-AMP-kinase activity Reactome:R-HSA-110145|Reactome:R-HSA-110141|EC:2.7.4.3|RHEA:12973|Reactome:R-HSA-74220|MetaCyc:ADENYL-KIN-RXN|Reactome:R-HSA-110144 molecular_function owl:Class
GO:1990743 biolink:NamedThing protein sialylation A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein. got7fsn_ti sl 2015-05-14T20:18:28Z biological_process owl:Class
GO:0021773 biolink:NamedThing striatal medium spiny neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum. got7fsn_ti striatal MSN differentiation|medium-sized spiny neuron differentiation biological_process owl:Class
GO:0035874 biolink:NamedThing cellular response to copper ion starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions. got7fsn_ti cellular response to copper starvation bf 2011-05-31T09:28:47Z biological_process owl:Class
GO:0039619 biolink:NamedThing T=4 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres. got7fsn_ti bf 2012-07-18T02:15:14Z VZ:808 cellular_component owl:Class
GO:1990223 biolink:NamedThing positive regulation by symbiont of cytokinin levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-16T15:27:27Z biological_process owl:Class
GO:0071725 biolink:NamedThing response to triacyl bacterial lipopeptide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus. got7fsn_ti response to triacylated bacterial lipoprotein Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. mah 2010-03-17T02:16:40Z biological_process owl:Class
GO:0072183 biolink:NamedThing negative regulation of nephron tubule epithelial cell differentiation Any process that decreases the frequency, rate or extent of nephron tubule epithelial cell differentiation. got7fsn_ti mah 2010-02-26T02:47:25Z biological_process owl:Class
GO:0048095 biolink:NamedThing female pigmentation Establishment of a pattern of pigment in females. got7fsn_ti biological_process owl:Class
GO:0072633 biolink:NamedThing interleukin-30 production The appearance of interleukin-30 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-30 complex production|interleukin-30 secretion|IL-30 production GO:0072634 biological_process owl:Class
GO:0036295 biolink:NamedThing cellular response to increased oxygen levels Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen. got7fsn_ti cellular response to raised oxygen levels This term should be used when an increase in oxygen levels is not considered a stress response. For a hyperoxic stress response, consider instead 'cellular response to hyperoxia ; GO:0071455'. bf 2012-07-20T01:09:39Z biological_process owl:Class
GO:0031826 biolink:NamedThing type 2A serotonin receptor binding Binding to a type 2A serotonin receptor. got7fsn_ti type 2A serotonin receptor ligand|5-hydroxytryptamine 2A receptor binding molecular_function owl:Class
GO:0008457 biolink:NamedThing beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide. got7fsn_ti UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity|poly-N-acetyllactosamine extension enzyme activity|uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase RHEA:23004|MetaCyc:2.4.1.163-RXN|EC:2.4.1.149 molecular_function owl:Class
GO:0052637 biolink:NamedThing delta 3-trans-hexadecenoic acid phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:3-3-16:0-phosphatidylglycerol = 1-18:3-3-trans-16:1-phosphatidylglycerol + 2 H+. This reaction is the formation of a trans double bond between carbon 3 and carbon 4 (counting from the carboxyl end) of palmitic acid, which is specifically esterified to the sn-2 glyceryl carbon of phosphatidylglycerol. got7fsn_ti molecular_function owl:Class
GO:0042323 biolink:NamedThing negative regulation of circadian sleep/wake cycle, non-REM sleep Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep. got7fsn_ti down regulation of circadian sleep/wake cycle, non-REM sleep|inhibition of circadian sleep/wake cycle, non-REM sleep|negative regulation of non-REM sleep|downregulation of circadian sleep/wake cycle, non-REM sleep|down-regulation of circadian sleep/wake cycle, non-REM sleep biological_process owl:Class
GO:0045188 biolink:NamedThing regulation of circadian sleep/wake cycle, non-REM sleep Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep. got7fsn_ti regulation of non-REM sleep biological_process owl:Class
GO:0034389 biolink:NamedThing lipid droplet organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. got7fsn_ti lipid particle organization|lipid body organization|lipid particle organisation|adiposome organization|lipid particle organization and biogenesis https://github.com/geneontology/go-ontology/issues/15963|https://github.com/geneontology/go-ontology/issues/13534 biological_process owl:Class
GO:0010161 biolink:NamedThing red light signaling pathway The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs. got7fsn_ti red light signalling pathway|red light phototransduction|red light signal transduction biological_process owl:Class
GO:0070701 biolink:NamedThing mucus layer An extracellular region part that consists of a protective layer of mucus secreted by epithelial cells lining tubular organs of the body such as the colon or secreted into fluids such as saliva. Mucus is a viscous slimy secretion consisting of mucins (i.e. highly glycosylated mucin proteins) and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. got7fsn_ti mucous|mucus|extracellular proteinaceous gel|mucous layer mah 2009-06-08T02:31:34Z cellular_component owl:Class
GO:0030305 biolink:NamedThing heparanase activity Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. got7fsn_ti heparinase activity Reactome:R-HSA-1667005|Reactome:R-HSA-1678694 molecular_function owl:Class
GO:0048322 biolink:NamedThing axial mesodermal cell fate commitment The process in which a cell becomes committed to become an axial mesoderm cell. got7fsn_ti axial mesoderm cell fate commitment biological_process owl:Class
GO:0051522 biolink:NamedThing activation of monopolar cell growth Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell. got7fsn_ti biological_process owl:Class
GO:0051515 biolink:NamedThing positive regulation of monopolar cell growth Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. got7fsn_ti upregulation of monopolar cell growth|up regulation of monopolar cell growth|up-regulation of monopolar cell growth|stimulation of monopolar cell growth biological_process owl:Class
GO:0060470 biolink:NamedThing positive regulation of cytosolic calcium ion concentration involved in egg activation The process that increases the concentration of calcium ions in the cytosol after fertilization or the physiological activation of an egg. got7fsn_ti elevation of cytosolic calcium ion concentration involved in egg activation biological_process owl:Class
GO:0021996 biolink:NamedThing lamina terminalis formation The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore. got7fsn_ti biological_process owl:Class
GO:0050688 biolink:NamedThing regulation of defense response to virus Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism. got7fsn_ti regulation of antiviral response biological_process owl:Class
GO:0046695 biolink:NamedThing SLIK (SAGA-like) complex A SAGA-type histone acetyltransferase complex that contains a smaller form of Spt7 (lacking the SPT8 binding region) than the fungal SAGA complex, and consequently lacks Spt8. The complex is involved in the yeast retrograde response pathway, which is important for gene expression changes during mitochondrial dysfunction. got7fsn_ti SAGA (alt) complex|SLIK/SALSA complex|SALSA complex See also the cellular component term 'SAGA complex ; GO:0000124'. cellular_component owl:Class
GO:0047035 biolink:NamedThing testosterone dehydrogenase (NAD+) activity Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. got7fsn_ti 3alpha,17beta-hydroxy steroid dehydrogenase activity|17beta-hydroxysteroid:NAD+ 17-oxidoreductase activity|17-ketoreductase activity|17beta-HSD|17-beta-HSD activity|3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)|3alpha(17beta)-HSD|testosterone 17beta-dehydrogenase activity|3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17b-dehydrogenase activity|3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase activity GO:0050327 KEGG_REACTION:R01836|MetaCyc:TESTOSTERONE-17-BETA-DEHYDROGENASE-RXN|MetaCyc:1.1.1.239-RXN|EC:1.1.1.239|RHEA:14929|Wikipedia:3alpha(17beta)-hydroxysteroid_dehydrogenase_(NAD+) molecular_function owl:Class
GO:0006452 biolink:NamedThing translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. got7fsn_ti Wikipedia:Translational_frameshift biological_process owl:Class
GO:0048402 biolink:NamedThing intermediate mesoderm structural organization The process that contributes to the act of creating the structural organization of the intermediate mesoderm. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti intermediate mesoderm structural organisation biological_process owl:Class
GO:2000942 biolink:NamedThing regulation of amylopectin metabolic process Any process that modulates the frequency, rate or extent of amylopectin metabolic process. got7fsn_ti regulation of Amylopectin metabolism tt 2011-08-01T02:10:28Z biological_process owl:Class
GO:0018164 biolink:NamedThing protein-DNA covalent cross-linking via peptidyl-threonine The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine. got7fsn_ti DNA-protein covalent cross-linking via peptidyl-threonine RESID:AA0255 biological_process owl:Class
GO:0032639 biolink:NamedThing TRAIL production The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti TRAIL biosynthetic process Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0045553 biological_process owl:Class
GO:0060370 biolink:NamedThing susceptibility to T cell mediated cytotoxicity The process of causing a cell to become susceptible to T cell mediated cytotoxicity. got7fsn_ti biological_process owl:Class
GO:0001916 biolink:NamedThing positive regulation of T cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. got7fsn_ti upregulation of T cell mediated cytotoxicity|stimulation of T cell mediated cytotoxicity|positive regulation of T cell mediated cytolysis|activation of T cell mediated cytotoxicity|positive regulation of T-lymphocyte mediated cytotoxicity|positive regulation of T cell mediated apoptosis|up-regulation of T cell mediated cytotoxicity|up regulation of T cell mediated cytotoxicity|positive regulation of T-cell mediated apoptosis|positive regulation of T cell mediated cell death|positive regulation of T-cell mediated cell death|positive regulation of T-cell mediated cell killing|positive regulation of T-cell mediated cytotoxicity|positive regulation of T cell mediated cell killing|positive regulation of T-cell mediated cytolysis|positive regulation of T lymphocyte mediated cytotoxicity biological_process owl:Class
GO:0140398 biolink:NamedThing versicolorin B desaturase activity Catalyzes the reaction: versicolorin B + NADPH + O(2) <=> versicolorin A + NADP(+) + 2 H(2)O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. got7fsn_ti pg 2019-11-29T10:30:25Z RHEA:35743|MetaCyc:RXN-9495|KEGG_REACTION:R10479 molecular_function owl:Class
GO:0072373 biolink:NamedThing alpha-carotene epsilon hydroxylase activity Catalysis of the reaction: alpha-carotene + NADPH + O2 + H+ = alpha-cryptoxanthin + NADP+ + H2O. got7fsn_ti mah 2010-11-19T03:52:25Z molecular_function owl:Class
GO:0018470 biolink:NamedThing 4-hydroxybutaraldehyde dehydrogenase activity Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate. got7fsn_ti UM-BBD_reactionID:r0014 molecular_function owl:Class
GO:0006035 biolink:NamedThing cuticle chitin biosynthetic process The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles. got7fsn_ti cuticle chitin synthesis|cuticle chitin anabolism|cuticle chitin biosynthesis|cuticle chitin formation biological_process owl:Class
GO:0031386 biolink:NamedThing protein tag A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. got7fsn_ti ubiquitin-like protein modifier|covalent modifier|ubiquitin|protein tagging activity Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures. molecular_function owl:Class
GO:0008936 biolink:NamedThing nicotinamidase activity Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3. got7fsn_ti nicotine deamidase activity|NAMase activity|nicotinamide amidase activity|nicotinamide amidohydrolase activity|YNDase activity|nicotinamide deaminase activity MetaCyc:NICOTINAMID-RXN|EC:3.5.1.19|RHEA:14545 molecular_function owl:Class
GO:0019916 biolink:NamedThing peptidyl-D-alanine racemization, direct The racemization of peptidyl-alanine. got7fsn_ti RESID:AA0191 biological_process owl:Class
GO:0055022 biolink:NamedThing negative regulation of cardiac muscle tissue growth Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth. got7fsn_ti negative regulation of heart muscle growth|down-regulation of cardiac muscle growth|inhibition of cardiac muscle growth|downregulation of cardiac muscle growth|down regulation of cardiac muscle growth biological_process owl:Class
GO:0098769 biolink:NamedThing TIMP family protein binding Binding to a member of the Tissue inhibitors of metalloproteinases (TIMPs) family. TIMPs are endogenous protein regulators of the matrix metalloproteinase (MMPs) family. got7fsn_ti molecular_function owl:Class
GO:0007288 biolink:NamedThing sperm axoneme assembly The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement. got7fsn_ti biological_process owl:Class
GO:0048249 biolink:NamedThing high-affinity phosphate transmembrane transporter activity Enables the transfer of phosphate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity phosphate transmembrane transporter activity molecular_function owl:Class
GO:0015114 biolink:NamedThing phosphate ion transmembrane transporter activity Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. got7fsn_ti phosphate transmembrane transporter activity pr 2012-11-22T15:43:10Z GO:1901677 RHEA:32823 molecular_function owl:Class
GO:0035236 biolink:NamedThing proctolin receptor activity Combining with the neuropeptide proctolin, to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:1990092 biolink:NamedThing calcium-dependent self proteolysis The calcium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. got7fsn_ti sl 2013-05-06T17:33:34Z biological_process owl:Class
GO:0097264 biolink:NamedThing self proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. got7fsn_ti self-proteolysis|autolysis pr 2012-03-09T12:43:24Z biological_process owl:Class
GO:1902422 biolink:NamedThing hydrogen biosynthetic process The chemical reactions and pathways resulting in the formation of H2 (dihydrogen). got7fsn_ti dihydrogen synthesis|molecular hydrogen biosynthesis|H2 biosynthesis|hydrogen production|hydrogen synthesis|hydrogen anabolism|hydrogen biosynthesis|hydrogen generation|hydrogen formation jl 2013-09-18T14:34:32Z biological_process owl:Class
GO:0035287 biolink:NamedThing head segmentation Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial). got7fsn_ti See also the fly_anatomy.ontology term 'head segment ; FBbt:00000006' and its children. biological_process owl:Class
GO:0035574 biolink:NamedThing histone H4-K20 demethylation The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone. got7fsn_ti bf 2010-08-13T10:50:06Z biological_process owl:Class
GO:0061307 biolink:NamedThing cardiac neural crest cell differentiation involved in heart development The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches. got7fsn_ti dph 2010-09-23T08:50:56Z biological_process owl:Class
GO:0047706 biolink:NamedThing biochanin-A reductase activity Catalysis of the reaction: dihydrobiochanin A + NADP(+) = biochanin A + H(+) + NADPH. got7fsn_ti dihydrobiochanin-A:NADP+ delta2-oxidoreductase activity MetaCyc:BIOCHANIN-A-REDUCTASE-RXN|RHEA:12817|KEGG_REACTION:R02954|EC:1.3.1.46 molecular_function owl:Class
GO:0061386 biolink:NamedThing closure of optic fissure The closure of the temporary ventral gap in the optic cup that contributes to its shaping. got7fsn_ti closure or choriod fissure dph 2011-03-30T08:14:59Z biological_process owl:Class
GO:0006426 biolink:NamedThing glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. got7fsn_ti biological_process owl:Class
GO:1990536 biolink:NamedThing phosphoenolpyruvate transmembrane import into Golgi lumen The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane. got7fsn_ti vw 2014-11-14T10:17:01Z biological_process owl:Class
GO:0015714 biolink:NamedThing phosphoenolpyruvate transport The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0052837 biolink:NamedThing thiazole biosynthetic process The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position. got7fsn_ti thiazole synthesis|thiazole anabolism|thiazole formation|thiazole biosynthesis ai 2011-11-29T03:33:05Z biological_process owl:Class
GO:0030160 biolink:NamedThing synaptic receptor adaptor activity The binding activity of a molecule that provides a physical support bridging a synaptic signaling receptor and a downstream signaling molecule. got7fsn_ti GKAP/Homer scaffold protein|postsynaptic density scaffold protein|GKAP/Homer scaffold activity https://github.com/geneontology/go-ontology/issues/18409 molecular_function owl:Class
GO:0061680 biolink:NamedThing Entner-Doudoroff pathway through gluconate to D-glyceraldehyde The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde. got7fsn_ti dph 2015-01-22T08:51:31Z MetaCyc:ENTNER-DOUDOROFF-PWY-II biological_process owl:Class
GO:0098596 biolink:NamedThing imitative learning Learning in which new behaviors are acquired through imitation. got7fsn_ti dos 2014-04-10T11:00:39Z Wikipedia:Observational_learning#Observational_learning_compared_to_imitation|Wikipedia:Imitative_learning biological_process owl:Class
GO:0047249 biolink:NamedThing sarsapogenin 3-beta-glucosyltransferase activity Catalysis of the reaction: (25S)-5beta-spirostan-3beta-ol + UDP-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + H(+) + UDP. got7fsn_ti sarsapogenin 3beta-glucosyltransferase activity|uridine diphosphoglucose-sarsapogenin glucosyltransferase activity|UDPglucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity|UDP-glucose:(25S)-5beta-spirostan-3beta-ol 3-O-beta-D-glucosyltransferase activity RHEA:14461|KEGG_REACTION:R04359|EC:2.4.1.193|MetaCyc:2.4.1.193-RXN molecular_function owl:Class
GO:0102159 biolink:NamedThing baicalein 7-O-glucuronosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucuronate + baicalein <=> H+ + UDP + baicalin. got7fsn_ti MetaCyc:RXN-11755|EC:2.4.1.253|RHEA:28314 molecular_function owl:Class
GO:0098691 biolink:NamedThing dopaminergic synapse A synapse that uses dopamine as a neurotransmitter. got7fsn_ti dos 2017-03-07T14:51:52Z cellular_component owl:Class
GO:0061569 biolink:NamedThing UDP phosphorylation The process of introducing a phosphate group into UDP, uridine diphosphate, to produce UTP. got7fsn_ti dph 2013-08-01T12:59:32Z biological_process owl:Class
GO:0004460 biolink:NamedThing L-lactate dehydrogenase (cytochrome) activity Catalysis of the reaction: (S)-lactate + 2 [Fe(III)cytochrome c] = 2 [Fe(II)cytochrome c] + 2 H+ + pyruvate. got7fsn_ti lactic cytochrome c reductase activity|lactic acid dehydrogenase activity|(S)-lactate:ferricytochrome-c 2-oxidoreductase activity|dehydrogenase, lactate (cytochrome)|cytochrome b2|L(+)-lactate:cytochrome c oxidoreductase activity|L-lactate ferricytochrome c oxidoreductase activity|lactate dehydrogenase (cytochrome)|cytochrome b2 (flavin-free derivative of flavocytochrome b2)|flavocytochrome b2|L-lactate cytochrome c reductase activity|L-lactate cytochrome c oxidoreductase activity EC:1.1.2.3|MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN|RHEA:19909 molecular_function owl:Class
GO:0038183 biolink:NamedThing bile acid signaling pathway A series of molecular signals initiated by the binding of a bile acid to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti bf 2013-05-16T10:35:10Z biological_process owl:Class
GO:0061539 biolink:NamedThing octopamine secretion The controlled release of octopamine by a cell. got7fsn_ti dph 2013-06-21T16:24:02Z biological_process owl:Class
GO:0036001 biolink:NamedThing 'de novo' pyridoxal 5'-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components. got7fsn_ti 'de novo' pyridoxal 5'-phosphate formation|'de novo' pyridoxal 5'-phosphate biosynthesis|'de novo' pyridoxal 5'-phosphate anabolism|'de novo' PLP biosynthesis|'de novo' pyridoxal phosphate biosynthetic process|'de novo' pyridoxal 5'-phosphate synthesis bf 2011-09-06T02:04:53Z MetaCyc:PYRIDOXSYN-PWY biological_process owl:Class
GO:0042823 biolink:NamedThing pyridoxal phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. got7fsn_ti pyridoxal phosphate synthesis|pyridoxal phosphate anabolism|pyridoxal phosphate formation|pyridoxal phosphate biosynthesis|active vitamin B6 biosynthesis|active vitamin B6 biosynthetic process MetaCyc:PWY0-845 biological_process owl:Class
GO:0042864 biolink:NamedThing pyochelin biosynthetic process The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). got7fsn_ti pyochelin biosynthetic process, peptide formation|pyochelin formation|pyochelin synthesis|pyochelin biosynthetic process, peptide modification|pyochelin anabolism|pyochelin biosynthesis GO:0031187|GO:0031188 biological_process owl:Class
GO:0004715 biolink:NamedThing non-membrane spanning protein tyrosine kinase activity Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. got7fsn_ti cytoplasmic protein tyrosine kinase activity|focal adhesion kinase activity|janus kinase 3 activity|ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity|p60c-src protein tyrosine kinase activity|janus kinase 2 activity|janus kinase 1 activity|ATP:protein-tyrosine O-phosphotransferase activity|Bruton's tyrosine kinase activity|non-specific protein-tyrosine kinase activity Reactome:R-HSA-6786095|EC:2.7.10.2|Reactome:R-HSA-1112703|MetaCyc:2.7.10.2-RXN|Reactome:R-HSA-6786096|Reactome:R-HSA-6788582|Reactome:R-HSA-1168459|Reactome:R-HSA-879910|Reactome:R-HSA-8871373|Reactome:R-HSA-1369115|Reactome:R-HSA-437936|Reactome:R-HSA-432148|Reactome:R-HSA-1112602|Reactome:R-HSA-453200|Reactome:R-HSA-1295519|Reactome:R-HSA-1168767|Reactome:R-HSA-1168423 molecular_function owl:Class
GO:0030600 biolink:NamedThing feruloyl esterase activity Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide. got7fsn_ti 4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity|FAE-III|hydroxycinnamoyl esterase activity|FAE-II|ferulic acid esterase activity|FAE-I|hemicellulase accessory|FAEA|cinnAE|cinnamoyl ester hydrolase activity MetaCyc:3.1.1.73-RXN|EC:3.1.1.73 molecular_function owl:Class
GO:0051909 biolink:NamedThing acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate Catalysis of the reaction: 3-hydroxypropenoate = propynoate + H2O. got7fsn_ti 3-hydroxypropenoate dehydratase activity|alkynoate hydratase activity|acetylenemonocarboxylate hydratase activity|acetylenecarboxylate hydratase activity EC:4.2.1.27 molecular_function owl:Class
GO:1990048 biolink:NamedThing anterograde neuronal dense core vesicle transport The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse. got7fsn_ti anterograde dense core granule trafficking|anterograde dense core granule transport biological_process owl:Class
GO:0032536 biolink:NamedThing regulation of cell projection size A process that modulates the size of a cell projection. got7fsn_ti biological_process owl:Class
GO:0052715 biolink:NamedThing mannosyl-diinositol phosphorylceramide phospholipase activity Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol. got7fsn_ti ai 2011-08-05T08:02:57Z molecular_function owl:Class
GO:0051610 biolink:NamedThing serotonin uptake The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems. got7fsn_ti 5-HT uptake|5HT uptake|5-hydroxytryptamine uptake|serotonin import biological_process owl:Class
GO:0086100 biolink:NamedThing endothelin receptor signaling pathway A series of molecular signals initiated by an endothelin receptor binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti endothelin signaling pathway bf biological_process owl:Class
GO:0006728 biolink:NamedThing pteridine biosynthetic process The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group. got7fsn_ti pteridine formation|pterin biosynthesis|pterin biosynthetic process|pteridine synthesis|pteridine biosynthesis|pteridine anabolism biological_process owl:Class
GO:1990181 biolink:NamedThing acetyl-CoA biosynthetic process from pantothenate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA. got7fsn_ti acetyl-CoA synthesis from pantothenate|acetyl-CoA anabolism from pantothenate|acetyl-CoA formation from pantothenate mah 2013-08-30T16:20:44Z biological_process owl:Class
GO:0044482 biolink:NamedThing envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism. got7fsn_ti envenomation resulting in blood vessel ECM, causing hemorrhagic damage in other organism jl 2012-01-19T03:12:04Z biological_process owl:Class
GO:0099503 biolink:NamedThing secretory vesicle A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. got7fsn_ti cellular_component owl:Class
GO:0043838 biolink:NamedThing phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol. got7fsn_ti phosphoethanolamine transferase|EptB Note that Kdo is an abbreviation for 3-deoxy-D-manno-oct-2-ulosonic acid. molecular_function owl:Class
GO:0033118 biolink:NamedThing esterosome membrane The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes. got7fsn_ti cellular_component owl:Class
GO:0034853 biolink:NamedThing 2,4,4-trimethyl-3-oxopentanoate decarboxylase activity Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2. got7fsn_ti UM-BBD_reactionID:r1278 molecular_function owl:Class
GO:0035841 biolink:NamedThing new growing cell tip A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth. got7fsn_ti post-NETO new cell end|new cell tip after activation of bipolar cell growth|post-new end take-off new cell tip|post-NETO new cell tip bf 2011-05-06T01:35:07Z cellular_component owl:Class
GO:0009522 biolink:NamedThing photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). got7fsn_ti cellular_component owl:Class
GO:0018845 biolink:NamedThing 2-hydroxychromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate. got7fsn_ti EC:5.99.1.4|UM-BBD_reactionID:r0337|MetaCyc:RXNN-386|RHEA:27401|KEGG_REACTION:R05137 molecular_function owl:Class
GO:0018494 biolink:NamedThing carvone reductase activity Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone. got7fsn_ti MetaCyc:RXN-9419|MetaCyc:RXN-9403|EC:1.3.99.25|UM-BBD_reactionID:r0732 molecular_function owl:Class
GO:0102198 biolink:NamedThing L-idonate 5-dehydrogenase activity (NAD-dependent) Catalysis of the reaction: L-idonate + NAD = 5-dehydro-D-gluconate + NADH + H+. got7fsn_ti EC:1.1.1.366|MetaCyc:RXN-12107|RHEA:21172 molecular_function owl:Class
GO:0015824 biolink:NamedThing proline transport The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-proline transport biological_process owl:Class
GO:0050476 biolink:NamedThing acetylenedicarboxylate decarboxylase activity Catalysis of the reaction: H2O + acetylenedicarboxylate = CO2 + pyruvate. got7fsn_ti acetylenedicarboxylate hydrase activity|acetylenedicarboxylate carboxy-lyase activity|acetylenedicarboxylate carboxy-lyase (pyruvate-forming)|acetylenedicarboxylate hydratase activity EC:4.1.1.78|MetaCyc:4.1.1.78-RXN|RHEA:17733 molecular_function owl:Class
GO:0003849 biolink:NamedThing 3-deoxy-7-phosphoheptulonate synthase activity Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate. got7fsn_ti 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate|3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity|D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity|7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity|2-dehydro-3-deoxyphosphoheptonate aldolase activity|KDPH synthase activity|phospho-2-keto-3-deoxyheptanoate aldolase activity|3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity|KDPH synthetase activity|DS-Mn activity|DAHP synthase activity|3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity|deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity|DHAP synthase activity|phospho-2-keto-3-deoxyheptonate aldolase activity|phospho-2-oxo-3-deoxyheptonate aldolase activity|2-dehydro-3-deoxy-phosphoheptonate aldolase activity|D-erythrose-4-phosphate-lyase activity|DAH7-P synthase activity|2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity|DS-Co activity|phospho-2-keto-3-deoxyheptonic aldolase activity|7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity|phospho-2-dehydro-3-deoxyheptonate aldolase activity|phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming) Note that this function was formerly EC:4.1.2.15. KEGG_REACTION:R01826|EC:2.5.1.54|MetaCyc:DAHPSYN-RXN|RHEA:14717 molecular_function owl:Class
GO:0090250 biolink:NamedThing cell-cell adhesion involved in establishment of planar polarity The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity. got7fsn_ti tb 2010-01-22T11:28:03Z biological_process owl:Class
GO:0102868 biolink:NamedThing 24-epi-campsterol desaturase activity Catalysis of the reaction: 24-epi-campesterol + NADPH + H+ + O2 <=> brassicasterol + NADP + 2 H2O. got7fsn_ti MetaCyc:RXN-8352 molecular_function owl:Class
GO:0033831 biolink:NamedThing kojibiose phosphorylase activity Catalysis of the reaction: kojibiose + phosphate = beta-D-glucose 1-phosphate + D-glucose. got7fsn_ti 2-alpha-D-glucosyl-D-glucose:phosphate beta-D-glucosyltransferase activity EC:2.4.1.230|MetaCyc:2.4.1.230-RXN|KEGG_REACTION:R07264|RHEA:11176 molecular_function owl:Class
GO:0052156 biolink:NamedThing modulation by symbiont of host T-cell mediated immune response Any process in which an organism modulates the frequency, rate or extent of the T-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of T-cell mediated immune response of other organism involved in symbiotic interaction GO:0052295 biological_process owl:Class
GO:0032165 biolink:NamedThing prospore septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation. got7fsn_ti cellular_component owl:Class
GO:0032160 biolink:NamedThing septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans. got7fsn_ti septin bar cellular_component owl:Class
GO:0090127 biolink:NamedThing positive regulation of synapse maturation by synaptic transmission Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse. got7fsn_ti tb 2009-12-07T02:57:21Z biological_process owl:Class
GO:0090129 biolink:NamedThing positive regulation of synapse maturation Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. got7fsn_ti tb 2009-12-07T03:00:58Z biological_process owl:Class
GO:0008929 biolink:NamedThing methylglyoxal synthase activity Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate. got7fsn_ti glycerone-phosphate phospho-lyase (methylglyoxal-forming)|glycerone-phosphate phospho-lyase activity|methylglyoxal synthetase activity EC:4.2.3.3|MetaCyc:METHGLYSYN-RXN|KEGG_REACTION:R01016|RHEA:17937 molecular_function owl:Class
GO:0071528 biolink:NamedThing tRNA re-export from nucleus The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export. got7fsn_ti tRNA reexport from nucleus mah 2010-01-07T04:17:05Z biological_process owl:Class
GO:0006409 biolink:NamedThing tRNA export from nucleus The directed movement of tRNA from the nucleus to the cytoplasm. got7fsn_ti tRNA export out of nucleus|tRNA transport from nucleus to cytoplasm|tRNA export from cell nucleus|tRNA-nucleus export biological_process owl:Class
GO:0006712 biolink:NamedThing mineralocorticoid catabolic process The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. got7fsn_ti mineralocorticoid catabolism|mineralocorticoid breakdown|mineralocorticoid degradation biological_process owl:Class
GO:0018942 biolink:NamedThing organometal metabolic process The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms. got7fsn_ti organometal metabolism biological_process owl:Class
GO:0080064 biolink:NamedThing 4,4-dimethyl-9beta,19-cyclopropylsterol oxidation A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4,4-dimethyl-9beta,19-cyclopropylsterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy, 4-beta-methyl-9beta,19-cyclopropylsterol + 3 NADP+ + 3 H2O. got7fsn_ti 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity dhl 2009-04-13T03:39:58Z biological_process owl:Class
GO:1990390 biolink:NamedThing protein K33-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is added to a protein. got7fsn_ti sp 2014-06-03T12:22:05Z biological_process owl:Class
GO:0042568 biolink:NamedThing insulin-like growth factor binary complex A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development. got7fsn_ti IGF binary complex cellular_component owl:Class
GO:0035935 biolink:NamedThing androgen secretion The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates. got7fsn_ti bf 2011-07-20T01:11:31Z biological_process owl:Class
GO:0061245 biolink:NamedThing establishment or maintenance of bipolar cell polarity Any cellular process that results in the specification, formation or maintenance of a bipolar intracellular organization or cell growth patterns. got7fsn_ti dph 2010-08-23T09:42:05Z biological_process owl:Class
GO:0035163 biolink:NamedThing embryonic hemocyte differentiation The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. got7fsn_ti embryonic arthropod blood cell differentiation|embryonic hemocyte cell differentiation biological_process owl:Class
GO:0090616 biolink:NamedThing mitochondrial mRNA 3'-end processing Any process involved in forming the mature 3' end of an mRNA molecule that derives from the mitochondrial genome. got7fsn_ti tb 2014-10-24T12:45:08Z biological_process owl:Class
GO:0001176 biolink:NamedThing transcriptional start site selection at bacterial-type RNA polymerase promoter Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. got7fsn_ti krc 2011-06-20T01:48:56Z biological_process owl:Class
GO:0120304 biolink:NamedThing integument-mediated background adaptation Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by light sensitive cells in the integument. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20524 krc 2021-02-09T18:41:07Z biological_process owl:Class
GO:0035334 biolink:NamedThing Notch receptor processing, ligand-independent The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface. got7fsn_ti Notch S1 cleavage bf 2010-02-26T02:32:46Z biological_process owl:Class
GO:0016262 biolink:NamedThing protein N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. got7fsn_ti N-GlcNAc transferase activity|UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity|uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity|UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity GO:0016253 EC:2.4.1.94|MetaCyc:2.4.1.94-RXN|RHEA:16533 molecular_function owl:Class
GO:0050449 biolink:NamedThing casbene synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate. got7fsn_ti geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)|casbene synthetase activity|geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming) MetaCyc:CASBENE-SYNTHASE-RXN|EC:4.2.3.8|KEGG_REACTION:R02064|RHEA:14901 molecular_function owl:Class
GO:0061294 biolink:NamedThing mesonephric renal vesicle induction Signaling at short range between cells of the ureteric bud terminus and the kidney mesenchyme that positively regulates the formation of the mesonephric renal vesicle. got7fsn_ti dph 2010-09-03T12:57:59Z biological_process owl:Class
GO:0102566 biolink:NamedThing 1-acyl dihydroxyacetone phosphate reductase activity Catalysis of the reaction: 1-oleoylglycerone 3-phosphate + NADPH + H+ = 1-oleoyl-sn-glycero-3-phosphate + NADP. got7fsn_ti EC:1.1.1.101|MetaCyc:RXN-15046 molecular_function owl:Class
GO:0004146 biolink:NamedThing dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. got7fsn_ti dihydrofolic acid reductase activity|5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity|dihydrofolate reductase:thymidylate synthase activity|folic acid reductase activity|thymidylate synthetase-dihydrofolate reductase activity|NADPH-dihydrofolate reductase activity|7,8-dihydrofolate reductase activity|dihydrofolate reduction|tetrahydrofolate dehydrogenase activity|dihydrofolic reductase activity|folic reductase activity|DHFR|pteridine reductase:dihydrofolate reductase activity MetaCyc:DIHYDROFOLATEREDUCT-RXN|RHEA:15009|Reactome:R-HSA-1497794|EC:1.5.1.3 molecular_function owl:Class
GO:0004168 biolink:NamedThing dolichol kinase activity Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate. got7fsn_ti CTP:dolichol O-phosphotransferase activity|dolichol phosphokinase activity EC:2.7.1.108|Reactome:R-HSA-446195|RHEA:13133|Reactome:R-HSA-4755600|MetaCyc:DOLICHOL-KINASE-RXN molecular_function owl:Class
GO:0033982 biolink:NamedThing 3-dehydro-L-gulonate-6-phosphate decarboxylase activity Catalysis of the reaction: 3-dehydro-L-gulonate 6-phosphate + H(+) = L-xylulose 5-phosphate + CO(2). got7fsn_ti 3-keto-L-gulonate 6-phosphate decarboxylase activity|3-dehydro-L-gulonate-6-phosphate carboxy-lyase activity|SgaH|3-dehydro-L-gulonate-6-phosphate carboxy-lyase (L-xylulose-5-phosphate-forming) activity|KGPDC|SgbH|UlaD MetaCyc:RXN0-705|KEGG_REACTION:R07125|RHEA:14353|EC:4.1.1.85 molecular_function owl:Class
GO:0061340 biolink:NamedThing establishment or maintenance of monopolar cell polarity regulating cell shape Any cellular process that results in the specification, formation or maintenance of a monopolar intracellular organization or cell growth patterns that regulate the shape of a cell. got7fsn_ti dph 2010-09-29T09:13:55Z biological_process owl:Class
GO:0014881 biolink:NamedThing regulation of myofibril size Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. got7fsn_ti change of myofibril size biological_process owl:Class
GO:0014743 biolink:NamedThing regulation of muscle hypertrophy Any process that modulates the frequency, rate or extent of muscle hypertrophy. got7fsn_ti biological_process owl:Class
GO:0090163 biolink:NamedThing establishment of epithelial cell planar polarity The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue. got7fsn_ti tb 2009-12-08T08:59:57Z biological_process owl:Class
GO:0015621 biolink:NamedThing ferric triacetylfusarinine C transmembrane transporter activity Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042495 biolink:NamedThing detection of triacyl bacterial lipopeptide The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups. got7fsn_ti perception of triacylated bacterial lipopeptide|detection of triacylated bacterial lipoprotein|perception of triacylated bacterial lipoprotein Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. biological_process owl:Class
GO:0070340 biolink:NamedThing detection of bacterial lipopeptide The series of events in which a bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0140023 biolink:NamedThing tRNA adenosine deamination to inosine The removal of an amine group from an adenosine to produce inosine within a tRNA molecule. got7fsn_ti A-to-I tRNA editing pg 2017-04-26T05:56:51Z biological_process owl:Class
GO:0140616 biolink:NamedThing iodotyrosine deiodinase activity Catalyzes the reaction: 2 iodide + L-tyrosine + 2 NADP+ = 3,5-diiodo-L-tyrosine + H+ + 2 NADPH. got7fsn_ti monoiodotyrosine deiodinase activity|iodotyrosine deiodase activity|iodotyrosine deiodinase activity|iodide peroxidase-tyrosine iodinase activity|tyrosine iodinase activity https://github.com/geneontology/go-ontology/issues/21027 pg 2021-03-08T15:36:42Z RHEA:32479|EC:1.21.1.1 molecular_function owl:Class
GO:0046026 biolink:NamedThing precorrin-4 C11-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5. got7fsn_ti S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity|CobM EC:2.1.1.133|RHEA:22012|MetaCyc:2.1.1.133-RXN molecular_function owl:Class
GO:0008352 biolink:NamedThing katanin complex A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa). got7fsn_ti Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'. cellular_component owl:Class
GO:0070692 biolink:NamedThing CTDK-1 complex A positive transcription elongation factor complex that comprises the CDK kinase CTK1 (in budding yeast), Lsk1 (in fission yeast) (corresponding to the Panther PTHR24056:SF39 family), a cyclin and an additional gamma subunit (corresponding to the InterPRO entry IPR024638). got7fsn_ti Ctk complex|CTDK-I complex|trimeric positive transcription elongation factor complex b|C-terminal domain kinase I complex mah 2009-06-03T03:18:04Z cellular_component owl:Class
GO:0047300 biolink:NamedThing pyridoxamine-pyruvate transaminase activity Catalysis of the reaction: pyridoxamine + pyruvate = L-alanine + pyridoxal. got7fsn_ti pyridoxamine-pyruvate aminotransferase activity|pyridoxamine:pyruvate aminotransferase activity|pyridoxamine--pyruvate aminotransferase activity|pyridoxamineu-pyruvic transaminase activity|pyridoxamine-pyruvic transaminase KEGG_REACTION:R01712|MetaCyc:2.6.1.30-RXN|RHEA:12841|EC:2.6.1.30 molecular_function owl:Class
GO:0032071 biolink:NamedThing regulation of endodeoxyribonuclease activity Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. got7fsn_ti endodeoxyribonuclease regulator biological_process owl:Class
GO:0097070 biolink:NamedThing ductus arteriosus closure The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs. got7fsn_ti pr 2011-06-15T04:00:46Z biological_process owl:Class
GO:0060619 biolink:NamedThing cell migration involved in mammary placode formation The orderly movement of epithelial cells within the mammary line that contributes to the formation of the mammary placode. got7fsn_ti dph 2009-05-18T09:41:49Z biological_process owl:Class
GO:0031665 biolink:NamedThing negative regulation of lipopolysaccharide-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide. got7fsn_ti inhibition of lipopolysaccharide-mediated signaling pathway|downregulation of lipopolysaccharide-mediated signaling pathway|down-regulation of lipopolysaccharide-mediated signaling pathway|down regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of LPS-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signalling pathway biological_process owl:Class
GO:0071494 biolink:NamedThing cellular response to UV-C Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm. got7fsn_ti cellular response to UV-C radiation stimulus|cellular response to UV-C light stimulus|cellular response to germicidal ultraviolet radiation stimulus|cellular response to UVC radiation stimulus|cellular response to UVC light stimulus|cellular response to shortwave ultraviolet light stimulus|cellular response to shortwave ultraviolet radiation stimulus|cellular response to germicidal ultraviolet light stimulus mah 2009-12-18T02:22:01Z biological_process owl:Class
GO:0080096 biolink:NamedThing phosphatidate-sterol O-acyltransferase activity Catalysis of the reaction: a phosphatidate + a sterol = a sterol ester + a lysophosphatidate. got7fsn_ti dhl 2009-04-23T03:41:42Z molecular_function owl:Class
GO:0035061 biolink:NamedThing interchromatin granule A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs). got7fsn_ti ICG NIF_Subcellular:sao1049471211 cellular_component owl:Class
GO:0003027 biolink:NamedThing regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions. got7fsn_ti carotid body chemoreceptor response to lowering of systemic arterial blood pressure|carotid body chemoreceptor regulation of systemic arterial blood pressure|vagal reflex|regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling biological_process owl:Class
GO:0022038 biolink:NamedThing corpus callosum development The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. got7fsn_ti biological_process owl:Class
GO:0070073 biolink:NamedThing clustering of voltage-gated calcium channels The process in which voltage-gated calcium channels become localized together in high densities. got7fsn_ti clustering of voltage-dependent calcium channels|voltage-gated calcium channel clustering|clustering of voltage gated calcium channels biological_process owl:Class
GO:0044026 biolink:NamedThing DNA hypermethylation An increase in the epigenetic methylation of cytosine and adenosine residues in DNA. got7fsn_ti biological_process owl:Class
GO:0050879 biolink:NamedThing multicellular organismal movement Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism. got7fsn_ti biological_process owl:Class
GO:1900549 biolink:NamedThing N',N'',N'''-triacetylfusarinine C metabolic process The chemical reactions and pathways involving N',N'',N'''-triacetylfusarinine C. got7fsn_ti N',N'',N'''-triacetylfusarinine C metabolism di 2012-05-15T12:59:06Z biological_process owl:Class
GO:0007370 biolink:NamedThing ventral furrow formation Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation. got7fsn_ti biological_process owl:Class
GO:0018816 biolink:NamedThing 2-hydroxyisobutyrate dehydratase activity Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate. got7fsn_ti UM-BBD_reactionID:r0618 molecular_function owl:Class
GO:0010564 biolink:NamedThing regulation of cell cycle process Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. got7fsn_ti biological_process owl:Class
GO:0010301 biolink:NamedThing xanthoxin dehydrogenase activity Catalysis of the reaction: NAD(+) + xanthoxin = (+)-abscisic aldehyde + H(+) + NADH. got7fsn_ti xanthoxin oxidase activity|xanthoxin:NAD+ oxidoreductase activity|ABA2 GO:0033710 MetaCyc:1.1.1.288-RXN|RHEA:12548|KEGG_REACTION:R06954|EC:1.1.1.288 molecular_function owl:Class
GO:0014047 biolink:NamedThing glutamate secretion The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system. got7fsn_ti biological_process owl:Class
GO:0050825 biolink:NamedThing ice binding Binding to ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. got7fsn_ti ice nucleation activity|antifreeze activity|ice nucleation inhibitor activity|ice crystal binding molecular_function owl:Class
GO:0047184 biolink:NamedThing 1-acylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. got7fsn_ti 1-acyl-sn-glycero-3-phosphocholine acyltransferase activity|lysolecithin acyltransferase activity|lysophosphatide acyltransferase activity|lysophosphatidylcholine acyltransferase activity|acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase activity|acyl coenzyme A-monoacylphosphatidylcholine acyltransferase activity|acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity GO:0000507 Reactome:R-HSA-1482794|MetaCyc:2.3.1.23-RXN|EC:2.3.1.23|RHEA:12937 molecular_function owl:Class
GO:0006478 biolink:NamedThing peptidyl-tyrosine sulfation The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine. got7fsn_ti peptidyl-tyrosine sulphation RESID:AA0172 biological_process owl:Class
GO:0047081 biolink:NamedThing 3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity Catalysis of the reaction: O2 + NADPH + H+ + 3-hydroxy-2-methylpyridine-5-carboxylate = NADP+ + 2-(acetamidomethylene)succinate. got7fsn_ti methylhydroxypyridinecarboxylate oxidase activity|methylhydroxypyridine carboxylate dioxygenase activity|3-hydroxy-3-methylpyridinecarboxylate dioxygenase activity|2-methyl-3-hydroxypyridine 5-carboxylic acid dioxygenase activity|3-hydroxy-2-methylpyridine-5-carboxylate,NADPH:oxygen oxidoreductase (decyclizing) RHEA:10864|MetaCyc:1.14.12.4-RXN|EC:1.14.13.242 molecular_function owl:Class
GO:0047708 biolink:NamedThing biotinidase activity Catalysis of the reaction: biotin amide + H2O = biotin + NH3. got7fsn_ti biotin-amide amidohydrolase activity|amidohydrolase biotinidase activity Reactome:R-HSA-4167509|Reactome:R-HSA-4225086|MetaCyc:BIOTINIDASE-RXN|Reactome:R-HSA-3325540|Reactome:R-HSA-3076905|RHEA:13081|EC:3.5.1.12 molecular_function owl:Class
GO:0047151 biolink:NamedThing methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + tRNA containing uridine at position 54 + FADH + H+ = tetrahydrofolate + tRNA containing ribothymidine at position 54 + FAD+. got7fsn_ti methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH-oxidizing) activity|5,10-methylenetetrahydrofolate:tRNA-UPsiC (uracil-5-)-methyl-transferase activity|folate-dependent ribothymidyl synthase activity|5,10-methylenetetrahydrofolate:tRNA (uracil-5-)-methyltransferase activity|methylenetetrahydrofolate-transfer ribonucleate uracil 5-methyltransferase activity KEGG_REACTION:R03704|MetaCyc:2.1.1.74-RXN|RHEA:16873|EC:2.1.1.74 molecular_function owl:Class
GO:0008728 biolink:NamedThing GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. got7fsn_ti ATP-GTP 3'-diphosphotransferase activity|guanosine pentaphosphate synthetase activity|GPSII|guanosine 5',3'-polyphosphate synthetase activity|stringent factor activity|GPSI|(p)ppGpp synthetase II|GTP pyrophosphokinase activity|guanosine 3',5'-polyphosphate synthase activity|ATP:GTP 3'-diphosphotransferase activity|ppGpp synthetase I activity|(p)ppGpp synthetase I MetaCyc:GTPPYPHOSKIN-RXN|EC:2.7.6.5|RHEA:22088 molecular_function owl:Class
GO:0051013 biolink:NamedThing microtubule severing The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends. got7fsn_ti microtubule severing activity biological_process owl:Class
GO:0010841 biolink:NamedThing positive regulation of circadian sleep/wake cycle, wakefulness Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep. got7fsn_ti biological_process owl:Class
GO:0003349 biolink:NamedThing epicardium-derived cardiac endothelial cell differentiation The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell. got7fsn_ti dph 2009-12-01T11:17:49Z biological_process owl:Class
GO:0032331 biolink:NamedThing negative regulation of chondrocyte differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation. got7fsn_ti down-regulation of chondrocyte differentiation|down regulation of chondrocyte differentiation|inhibition of chondrocyte differentiation|downregulation of chondrocyte differentiation biological_process owl:Class
GO:0061957 biolink:NamedThing NVT complex A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1. got7fsn_ti dph 2017-12-01T17:01:17Z cellular_component owl:Class
GO:0002395 biolink:NamedThing immune response in nasopharyngeal-associated lymphoid tissue An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids. got7fsn_ti immune response in NALT biological_process owl:Class
GO:0032031 biolink:NamedThing myosin I head/neck binding Binding to the head/neck region of a myosin I heavy chain. got7fsn_ti molecular_function owl:Class
GO:0033739 biolink:NamedThing preQ1 synthase activity Catalysis of the reaction: 7-aminomethyl-7-deazaguanine + 2 NADP(+) = 7-cyano-7-deazaguanine + 3 H(+) + 2 NADPH. got7fsn_ti preQ0 oxidoreductase activity|QueF|queuine:NADP+ oxidoreductase activity|7-cyano-7-deazaguanine reductase activity|preQ0 reductase activity|7-aminomethyl-7-carbaguanine:NADP+ oxidoreductase activity|queuine synthase activity|YkvM EC:1.7.1.13|KEGG_REACTION:R07605|RHEA:13409|MetaCyc:RXN0-4022 molecular_function owl:Class
GO:1990713 biolink:NamedThing survivin complex A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC). got7fsn_ti Baculoviral IAP repeat-containing protein 5 complex|survivin homodimer complex An example of this is BIRC5 in human (UniProt symbol O15392) in PMID:10949038 (inferred from physical interaction). bhm 2015-03-26T14:21:46Z cellular_component owl:Class
GO:0015680 biolink:NamedThing protein maturation by copper ion transfer A process that contributes to the delivery of copper ions to a target protein. got7fsn_ti intracellular copper ion delivery|intracellular copper ion transport|intracellular copper delivery biological_process owl:Class
GO:0034813 biolink:NamedThing benzo(a)pyrene 7,8-dioxygenase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol. got7fsn_ti UM-BBD_reactionID:r1137|EC:1.13.11.- molecular_function owl:Class
GO:0030215 biolink:NamedThing semaphorin receptor binding Binding to a semaphorin receptor. got7fsn_ti plexin binding|plexin ligand|semaphorin receptor ligand molecular_function owl:Class
GO:0014824 biolink:NamedThing artery smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart. got7fsn_ti biological_process owl:Class
GO:0102709 biolink:NamedThing S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity Catalysis of the reaction: N,N-dimethyl-beta-alanine + S-adenosyl-L-methionine = H+ + beta-alanine betaine + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-6464 molecular_function owl:Class
GO:0120274 biolink:NamedThing virus coreceptor activity Combining with a virus component, and in cooperation with a nearby primary receptor, initiating a change in cell activity. got7fsn_ti viral coreceptor activity https://github.com/geneontology/go-ontology/issues/20137 krc 2020-10-20T18:32:45Z molecular_function owl:Class
GO:0044637 biolink:NamedThing envenomation resulting in negative regulation of complement activation, classical pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism. got7fsn_ti jl 2012-07-05T04:46:56Z biological_process owl:Class
GO:0043958 biolink:NamedThing acryloyl-CoA reductase activity Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein. got7fsn_ti acrylyl-CoA reductase (NADH)|acryloyl-coenzyme A reductase activity|propionyl-CoA dehydrogenase Note that this function is part of the process of L-alanine fermentation to propionate. MetaCyc:RXN-8568|EC:1.3.99.3|RHEA:34471 molecular_function owl:Class
GO:1990425 biolink:NamedThing ryanodine receptor complex A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom. got7fsn_ti RyR An example of this is RyR1 in rabbit (P11716) in PMID:2550460 (inferred from electron microscopy). anm 2014-07-24T09:36:41Z cellular_component owl:Class
GO:0018737 biolink:NamedThing 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA. got7fsn_ti UM-BBD_reactionID:r0193 molecular_function owl:Class
GO:0033511 biolink:NamedThing luteolin biosynthetic process The chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one. got7fsn_ti luteolin anabolism|luteolin formation|luteolin synthesis|luteolin biosynthesis MetaCyc:PWY-5060 biological_process owl:Class
GO:0035691 biolink:NamedThing macrophage migration inhibitory factor signaling pathway A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti macrophage migration inhibitory factor signalling pathway|MIF signaling pathway bf 2011-02-25T11:31:21Z biological_process owl:Class
GO:0038168 biolink:NamedThing epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB. got7fsn_ti EGFR signaling pathway via IKK-dependent activation of NF-kappaB|EGFR signaling pathway via IKK/NF-kappaB cascade bf 2012-05-15T12:01:09Z biological_process owl:Class
GO:0043960 biolink:NamedThing L-erythro-3-methylmalyl-CoA dehydratase activity Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O. got7fsn_ti molecular_function owl:Class
GO:0102781 biolink:NamedThing isofucosterol hydroxylase activity Catalysis of the reaction: H+ + isofucosterol + O2 + NADPH <=> (22alpha)-hydroxy-isofucosterol + H2O + NADP. got7fsn_ti MetaCyc:RXN-7877 molecular_function owl:Class
GO:0042862 biolink:NamedThing achromobactin catabolic process The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore. got7fsn_ti achromobactin degradation|achromobactin catabolism|achromobactin breakdown biological_process owl:Class
GO:0102911 biolink:NamedThing (-)-secoisolariciresinol dehydrogenase activity Catalysis of the reaction: (-)-secoisolariciresinol + NAD <=> H+ + (-)-lactol + NADH. got7fsn_ti MetaCyc:RXN-8680 molecular_function owl:Class
GO:0070774 biolink:NamedThing phytoceramidase activity Catalysis of the reaction: a phytoceramide + H2O = a fatty acid + phytosphingosine. got7fsn_ti mah 2009-07-02T10:52:42Z Reactome:R-HSA-428262|MetaCyc:CERAMIDASE-YEAST-RXN|KEGG_REACTION:R06528 molecular_function owl:Class
GO:0050170 biolink:NamedThing peptidyl-glutaminase activity Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3. got7fsn_ti peptidoglutaminase activity|peptidyl-L-glutamine amidohydrolase activity|peptideglutaminase activity|peptidoglutaminase I activity MetaCyc:PEPTIDYL-GLUTAMINASE-RXN|RHEA:10032|EC:3.5.1.43 molecular_function owl:Class
GO:0016419 biolink:NamedThing S-malonyltransferase activity Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule. got7fsn_ti EC:2.3.1.39 molecular_function owl:Class
GO:0061446 biolink:NamedThing endocardial cushion cell fate determination The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. got7fsn_ti dph 2012-03-13T09:22:13Z biological_process owl:Class
GO:0034188 biolink:NamedThing apolipoprotein A-I receptor activity Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0030226 biolink:NamedThing apolipoprotein receptor activity Combining with an apolipoprotein to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0018365 biolink:NamedThing protein-serine epimerase activity Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine. got7fsn_ti protein-serine racemase activity RHEA:10660|EC:5.1.1.16|MetaCyc:5.1.1.16-RXN molecular_function owl:Class
GO:0016855 biolink:NamedThing racemase and epimerase activity, acting on amino acids and derivatives Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. got7fsn_ti EC:5.1.1.- molecular_function owl:Class
GO:0035126 biolink:NamedThing post-embryonic genitalia morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized. got7fsn_ti post-embryonic genital morphogenesis biological_process owl:Class
GO:0001616 biolink:NamedThing growth hormone secretagogue receptor activity Combining with ghrelin to initiate a change in cell activity. got7fsn_ti ghrelin receptor activity molecular_function owl:Class
GO:0140506 biolink:NamedThing endoplasmic reticulum-autophagosome adaptor activity The binding activity of a molecule that brings together an ER membrane and an autophagosome during reticulophagy. got7fsn_ti autophagosome-endoplasmic reticulum anchor|autophagosome-ER anchor|ER- autophagosome anchor https://github.com/geneontology/go-ontology/issues/19873 pg 2020-08-27T11:04:43Z molecular_function owl:Class
GO:0051665 biolink:NamedThing membrane raft localization Any process in which membrane rafts are transported to, or maintained in, a specific location. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. got7fsn_ti lipid raft localization|membrane raft localisation|establishment and maintenance of membrane raft localization biological_process owl:Class
GO:0033980 biolink:NamedThing phosphonopyruvate decarboxylase activity Catalysis of the reaction: 3-phosphonopyruvate + 2 H(+) = CO(2) + phosphonoacetaldehyde. got7fsn_ti 3-phosphonopyruvate carboxy-lyase activity|3-phosphonopyruvate carboxy-lyase (2-phosphonoacetaldehyde-forming) activity MetaCyc:4.1.1.82-RXN|KEGG_REACTION:R04053|RHEA:20768|EC:4.1.1.82 molecular_function owl:Class
GO:0040039 biolink:NamedThing inductive cell migration Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans. got7fsn_ti biological_process owl:Class
GO:0016617 biolink:NamedThing 4-oxoproline reductase activity Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+. got7fsn_ti hydroxyproline oxidase activity|4-hydroxy-L-proline:NAD+ oxidoreductase activity|hydroxy-L-proline oxidase activity MetaCyc:4-OXOPROLINE-REDUCTASE-RXN|RHEA:13601|EC:1.1.1.104 molecular_function owl:Class
GO:0018657 biolink:NamedThing toluene 3-monooxygenase activity Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene. got7fsn_ti EC:1.14.13.-|MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN|UM-BBD_enzymeID:e0224 molecular_function owl:Class
GO:0005637 biolink:NamedThing nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. got7fsn_ti nucleus inner membrane|inner nuclear membrane|inner envelope NIF_Subcellular:sao1612527463 cellular_component owl:Class
GO:0001859 biolink:NamedThing complement component C3dg receptor activity Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0019552 biolink:NamedThing glutamate catabolic process via 2-hydroxyglutarate The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP. got7fsn_ti glutamate fermentation via 2-hydroxyglutarate MetaCyc:P162-PWY biological_process owl:Class
GO:0019670 biolink:NamedThing anaerobic glutamate catabolic process The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP. got7fsn_ti glutamate fermentation biological_process owl:Class
GO:0002872 biolink:NamedThing negative regulation of natural killer cell tolerance induction Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction. got7fsn_ti down-regulation of natural killer cell tolerance induction|down regulation of natural killer cell tolerance induction|downregulation of natural killer cell tolerance induction|negative regulation of NK cell tolerance induction|inhibition of natural killer cell tolerance induction biological_process owl:Class
GO:0043917 biolink:NamedThing ribose 1,5-bisphosphate isomerase activity Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate. got7fsn_ti ribose-1,5-bisphosphate isomerase activity MetaCyc:RXN-8801|EC:5.3.1.29|RHEA:32243 molecular_function owl:Class
GO:0090581 biolink:NamedThing protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0102067 biolink:NamedThing geranylgeranyl diphosphate reductase activity Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP <=> 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+. got7fsn_ti MetaCyc:RXN-10625|RHEA:26229|EC:1.3.1.83 molecular_function owl:Class
GO:0036448 biolink:NamedThing cellular response to glucose-phosphate stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate. got7fsn_ti bf 2013-10-31T11:20:08Z biological_process owl:Class
GO:0036447 biolink:NamedThing cellular response to sugar-phosphate stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate. got7fsn_ti cellular response to presence of non-metabolizable sugars bf 2013-10-31T11:18:09Z biological_process owl:Class
GO:0046784 biolink:NamedThing viral mRNA export from host cell nucleus The directed movement of intronless viral mRNA from the host nucleus to the cytoplasm for translation. got7fsn_ti intronless viral mRNA transport from nucleus to cytoplasm|intronless viral mRNA-nucleus export|intronless viral mRNA export out of nucleus|intronless viral mRNA export from host cell nucleus|intronless viral mRNA export from host nucleus biological_process owl:Class
GO:0120249 biolink:NamedThing lateral wall of outer hair cell The lateral wall of an outer hair cell (OHC) is a unique trilaminate composite consisting of the plasma membrane, an underlying cytoskeletal network containing an actin-spectrin cortical lattice, and an adjacent system of circumferential lamellar organelles known as the subsurface cisternae. got7fsn_ti outer hair cell lateral wall|lateral wall of OHC|OHC lateral wall krc 2020-08-27T23:53:44Z cellular_component owl:Class
GO:0097574 biolink:NamedThing lateral part of cell The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells. got7fsn_ti pr 2014-02-26T13:27:27Z cellular_component owl:Class
GO:0060594 biolink:NamedThing mammary gland specification The regionalization process in which the mammary line is specified. The mammary line is a ridge of epidermal cells that will form the mammary placodes. got7fsn_ti mammary line specification dph 2009-05-13T10:09:10Z biological_process owl:Class
GO:0106186 biolink:NamedThing cytoplasmic side of plasma membrane, cell tip The leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. got7fsn_ti hjd 2019-05-01T17:48:02Z cellular_component owl:Class
GO:0009898 biolink:NamedThing cytoplasmic side of plasma membrane The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface. got7fsn_ti internal leaflet of plasma membrane|juxtamembrane|internal side of plasma membrane cellular_component owl:Class
GO:0060958 biolink:NamedThing endocardial cell development The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. got7fsn_ti dph 2009-09-29T03:26:59Z biological_process owl:Class
GO:0042169 biolink:NamedThing SH2 domain binding Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. got7fsn_ti molecular_function owl:Class
GO:0021516 biolink:NamedThing dorsal spinal cord development The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input. got7fsn_ti biological_process owl:Class
GO:0004121 biolink:NamedThing cystathionine beta-lyase activity Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. got7fsn_ti beta-cystathionase activity|cystathionine L-homocysteine-lyase (deaminating)|L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)|beta C-S lyase activity|L-cystathionine L-homocysteine-lyase (deaminating)|cystine lyase activity GO:0008799 EC:4.4.1.8|RHEA:13965|MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN molecular_function owl:Class
GO:0051393 biolink:NamedThing alpha-actinin binding Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. got7fsn_ti nonmuscle alpha-actinin binding|alpha-actinin 4 binding|alpha-actinin 1 binding GO:0051372 molecular_function owl:Class
GO:0042805 biolink:NamedThing actinin binding Binding to actinin, any member of a family of proteins that crosslink F-actin. got7fsn_ti capZ binding|beta-actinin binding GO:0051406 molecular_function owl:Class
GO:0001861 biolink:NamedThing complement component C4b receptor activity Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:1990169 biolink:NamedThing stress response to copper ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus. got7fsn_ti response to copper ion stress|stress response to copper|response to copper toxicity pr 2013-08-14T12:52:05Z biological_process owl:Class
GO:0046688 biolink:NamedThing response to copper ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. got7fsn_ti response to copper|copper sensitivity/resistance biological_process owl:Class
GO:0044475 biolink:NamedThing envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism. got7fsn_ti jl 2012-01-19T02:28:11Z biological_process owl:Class
GO:0039611 biolink:NamedThing suppression by virus of host translation initiation factor activity Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor. got7fsn_ti inhibition of activity of host translation initiation factor|inactivation of eIF2 activity|Inhibition of host translation factors by virus|suppression by virus of host EIF-4E activity bf 2012-07-06T10:27:16Z biological_process owl:Class
GO:0033732 biolink:NamedThing pyrroloquinoline-quinone synthase activity Catalysis of the reaction: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 2 H(2)O + 2 H(2)O(2) + H(+) + pyrroloquinoline quinone. got7fsn_ti 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate:oxygen oxidoreductase (cyclizing) activity|PqqC EC:1.3.3.11|KEGG_REACTION:R07353|RHEA:10692|MetaCyc:1.3.3.11-RXN molecular_function owl:Class
GO:0044061 biolink:NamedThing modulation by symbiont of host excretion The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity. got7fsn_ti regulation by symbiont of host excretion biological_process owl:Class
GO:1990263 biolink:NamedThing spore wall assembly MAPK cascade A MAPK cascade that occurs as a result of deprivation of nourishment. got7fsn_ti MAPK cascade involved in nutrient response signaling|MAPK cascade in response to starvation al 2014-01-09T12:27:52Z biological_process owl:Class
GO:0034718 biolink:NamedThing SMN-Gemin2 complex A protein complex that contains the survival motor neuron (SMN) protein and Gemin2; may form the stable core of the larger SMN complex. got7fsn_ti cellular_component owl:Class
GO:0055076 biolink:NamedThing transition metal ion homeostasis Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. got7fsn_ti biological_process owl:Class
GO:0071463 biolink:NamedThing cellular response to humidity Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere. got7fsn_ti mah 2009-12-18T11:33:55Z biological_process owl:Class
GO:0010064 biolink:NamedThing embryonic shoot morphogenesis The process in which the anatomical structures of embryonic shoot are generated and organized. got7fsn_ti primary shoot system morphogenesis biological_process owl:Class
GO:0031886 biolink:NamedThing type 1 member 3 taste receptor binding Binding to a type 1 member 3 taste receptor. got7fsn_ti sweet taste receptor binding|type 1 member 3 taste receptor ligand molecular_function owl:Class
GO:0050432 biolink:NamedThing catecholamine secretion The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. got7fsn_ti biological_process owl:Class
GO:0072566 biolink:NamedThing chemokine (C-X-C motif) ligand 1 production The appearance of chemokine (C-X-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CXCL1 production|SCYB1 production|KC production|keratinocyte derived chemokine production mah 2011-01-31T11:31:58Z biological_process owl:Class
GO:1900339 biolink:NamedThing regulation of methane biosynthetic process from formic acid Any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid. got7fsn_ti tt 2012-04-06T02:04:53Z biological_process owl:Class
GO:0098773 biolink:NamedThing skin epidermis development The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0047456 biolink:NamedThing 2-methylisocitrate dehydratase activity Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O. got7fsn_ti (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase activity|(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] MetaCyc:4.2.1.99-RXN|EC:4.2.1.99|RHEA:17941|KEGG_REACTION:R04425 molecular_function owl:Class
GO:0090451 biolink:NamedThing cotyledon boundary formation The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained. got7fsn_ti tb 2012-09-19T10:26:54Z biological_process owl:Class
GO:0090691 biolink:NamedThing formation of plant organ boundary The regionalization process that specifies plant organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues. got7fsn_ti tb 2016-08-24T10:16:28Z biological_process owl:Class
GO:0140677 biolink:NamedThing molecular function activator activity A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21782 pg 2021-07-07T07:24:16Z molecular_function owl:Class
GO:0140431 biolink:NamedThing DNA-(abasic site) binding Binding to a DNA site that has neither a purine nor a pyrimidine base. Apurinic sites can form spontaneously or when DNA glycosylase removes a damaged base. got7fsn_ti DNA-(apurinic site) binding|DNA-(apurinic site/apyrimidinic site) binding|DNA AP site binding|DNA-(apyrimidinic site) binding https://github.com/geneontology/go-ontology/issues/18878 pg 2020-02-19T05:30:09Z molecular_function owl:Class
GO:1990667 biolink:NamedThing PCSK9-AnxA2 complex A protein complex consisting of the serine protease PCSK9 (proprotein convertase subtilisin/kexin-9) and annexin A2 (AnxA2). got7fsn_ti PCSK9.AnxA2 complex|PCSK9:ANXA2 complex|PCSK9-Annexin A2 complex bf 2015-03-02T10:33:09Z cellular_component owl:Class
GO:0035410 biolink:NamedThing dihydrotestosterone 17-beta-dehydrogenase activity Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH. got7fsn_ti bf 2010-03-24T10:48:41Z EC:1.1.1.51 molecular_function owl:Class
GO:0002948 biolink:NamedThing archaeosine synthase activity Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA. got7fsn_ti ArcS|glutamine:preQ0-tRNA amidinotransferase https://github.com/geneontology/go-ontology/issues/20486 hjd 2014-08-11T10:33:59Z Wikipedia:Archaeosine_synthase|EC:2.6.1.97|RHEA:54084 molecular_function owl:Class
GO:0006518 biolink:NamedThing peptide metabolic process The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. got7fsn_ti peptide metabolism biological_process owl:Class
GO:1990486 biolink:NamedThing anaerobic fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. got7fsn_ti anaerobic fatty acid degradation tt 2014-09-20T17:25:48Z biological_process owl:Class
GO:0033185 biolink:NamedThing dolichol-phosphate-mannose synthase complex A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively. got7fsn_ti DPM synthase complex|dolichyl-phosphate beta-D-mannosyltransferase complex cellular_component owl:Class
GO:0035708 biolink:NamedThing interleukin-4-dependent isotype switching to IgE isotypes The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4). got7fsn_ti IL-4-dependent isotype switching to IgE isotypes bf 2011-03-02T02:40:35Z biological_process owl:Class
GO:0048289 biolink:NamedThing isotype switching to IgE isotypes The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus. got7fsn_ti class switch recombination to IgE isotypes|isotype switch recombination to IgE isotypes|class switching to IgE isotypes biological_process owl:Class
GO:0042998 biolink:NamedThing positive regulation of Golgi to plasma membrane protein transport Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. got7fsn_ti activation of Golgi to plasma membrane protein transport|upregulation of Golgi to plasma membrane protein transport|stimulation of Golgi to plasma membrane protein transport|up-regulation of Golgi to plasma membrane protein transport|up regulation of Golgi to plasma membrane protein transport biological_process owl:Class
GO:0031592 biolink:NamedThing centrosomal corona An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin. got7fsn_ti Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material. cellular_component owl:Class
GO:0071204 biolink:NamedThing histone pre-mRNA 3'end processing complex A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1. got7fsn_ti histone 3'end pre-mRNA complex mah 2009-11-25T11:11:02Z cellular_component owl:Class
GO:0061729 biolink:NamedThing GDP-mannose biosynthetic process from fructose-6-phosphate The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate. got7fsn_ti dph 2015-07-24T14:50:44Z Reactome:R-HSA-446205 biological_process owl:Class
GO:0010224 biolink:NamedThing response to UV-B Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm. got7fsn_ti response to medium wave ultraviolet light stimulus|response to medium wave ultraviolet radiation stimulus|response to UVB radiation stimulus|response to UV-B radiation stimulus|response to UVB light stimulus|response to UV-B light stimulus biological_process owl:Class
GO:0004365 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. got7fsn_ti 3-phosphoglyceraldehyde dehydrogenase activity|NAD-dependent glyceraldehyde phosphate dehydrogenase activity|glyceraldehyde phosphate dehydrogenase (NAD)|glyceraldehyde-3-P-dehydrogenase activity|phosphoglyceraldehyde dehydrogenase activity|GAPDH activity|triosephosphate dehydrogenase activity|NADH-glyceraldehyde phosphate dehydrogenase activity|dehydrogenase, glyceraldehyde phosphate|NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity|D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating) MetaCyc:GAPOXNPHOSPHN-RXN|Reactome:R-HSA-70482|EC:1.2.1.12|RHEA:10300|Reactome:R-HSA-70449 molecular_function owl:Class
GO:0090105 biolink:NamedThing pancreatic E cell development The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure. got7fsn_ti tb 2009-11-18T11:51:00Z biological_process owl:Class
GO:0044395 biolink:NamedThing protein targeting to vacuolar membrane The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein. got7fsn_ti jl 2011-12-21T02:54:44Z biological_process owl:Class
GO:0043892 biolink:NamedThing methylglyoxal reductase (NADPH-dependent) activity Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+. got7fsn_ti Gre2|lactaldehyde dehydrogenase (NADP+)|lactaldehyde:NADP+ oxidoreductase activity RHEA:21748|EC:1.1.1.283|MetaCyc:RXN-8636|MetaCyc:1.1.1.283-RXN molecular_function owl:Class
GO:0103020 biolink:NamedThing 1-deoxy-D-xylulose kinase activity Catalysis of the reaction: 1-deoxy-D-xylulose + ATP <=> H+ + 1-deoxy-D-xylulose 5-phosphate + ADP. got7fsn_ti RHEA:27990|MetaCyc:RXN0-382 molecular_function owl:Class
GO:0019467 biolink:NamedThing ornithine catabolic process, by decarboxylation The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation. got7fsn_ti ornithine degradation, by decarboxylation|ornithine breakdown, by decarboxylation MetaCyc:ORNDEG-PWY biological_process owl:Class
GO:0006593 biolink:NamedThing ornithine catabolic process The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. got7fsn_ti ornithine catabolism|ornithine breakdown|ornithine degradation biological_process owl:Class
GO:0047710 biolink:NamedThing bis(5'-adenosyl)-triphosphatase activity Catalysis of the reaction: P(1),P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP + 2 H(+). got7fsn_ti P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase activity|1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase activity|dinucleosidetriphosphatase activity|AP(3)A hydrolase activity|AP3Aase activity|diadenosine 5,5-P1,P3-triphosphatase activity|AP3A hydrolase activity|diadenosine 5',5'''-P(1),P(3)-triphosphate hydrolase activity|diadenosine 5',5'''-P1,P3-triphosphate hydrolase activity|AP(3)Aase activity RHEA:13893|KEGG_REACTION:R00187|MetaCyc:BIS5-ADENOSYL-TRIPHOSPHATASE-RXN|EC:3.6.1.29 molecular_function owl:Class
GO:0002926 biolink:NamedThing tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine. got7fsn_ti tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis|mcm5 modification|mcm5s2U34 biosynthesis hjd 2012-01-17T02:50:54Z biological_process owl:Class
GO:0033150 biolink:NamedThing cytoskeletal calyx A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins. got7fsn_ti cellular_component owl:Class
GO:0033065 biolink:NamedThing Rad51C-XRCC3 complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof. got7fsn_ti CX3 complex cellular_component owl:Class
GO:0071908 biolink:NamedThing determination of intestine left/right asymmetry Determination of the asymmetric location of the intestine loops with respect to the left and right halves of the organism. got7fsn_ti mah 2010-09-22T10:24:33Z biological_process owl:Class
GO:0031387 biolink:NamedThing MPF complex A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC). got7fsn_ti cellular_component owl:Class
GO:0046335 biolink:NamedThing ethanolamine biosynthetic process The chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). got7fsn_ti ethanolamine synthesis|ethanolamine anabolism|ethanolamine formation|ethanolamine biosynthesis biological_process owl:Class
GO:0001758 biolink:NamedThing retinal dehydrogenase activity Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. got7fsn_ti cytosolic retinal dehydrogenase activity|retinal:NAD+ oxidoreductase activity MetaCyc:RETINAL-DEHYDROGENASE-RXN|RHEA:16177|Reactome:R-HSA-5362522|EC:1.2.1.36|Reactome:R-HSA-5696101 molecular_function owl:Class
GO:0036474 biolink:NamedThing cell death in response to hydrogen peroxide Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2). got7fsn_ti cell death in response to H2O2|hydrogen peroxide-mediated cell death This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0010421 'hydrogen peroxide-mediated programmed cell death'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. bf 2014-07-21T11:42:28Z biological_process owl:Class
GO:0022809 biolink:NamedThing mobile ion carrier activity Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane. got7fsn_ti ionophore molecular_function owl:Class
GO:0030713 biolink:NamedThing ovarian follicle cell stalk formation Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0102732 biolink:NamedThing myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP. got7fsn_ti MetaCyc:RXN-7186|EC:2.7.1.140 molecular_function owl:Class
GO:0034819 biolink:NamedThing 3-HSA hydroxylase activity Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O. got7fsn_ti UM-BBD_reactionID:r1150|EC:1.14.13.- molecular_function owl:Class
GO:0046581 biolink:NamedThing intercellular canaliculus An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates. got7fsn_ti cellular_component owl:Class
GO:0030953 biolink:NamedThing astral microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles. got7fsn_ti astral microtubule organisation|astral microtubule organization and biogenesis biological_process owl:Class
GO:0033741 biolink:NamedThing adenylyl-sulfate reductase (glutathione) activity Catalysis of the reaction: AMP + glutathione disulfide + H(+) + sulfite = 5'-adenylyl sulfate + 2 glutathione. got7fsn_ti plant-type 5'-adenylylsulfate reductase activity|AMP,sulfite:oxidized-glutathione oxidoreductase (adenosine-5'-phosphosulfate-forming) activity|5'-adenylylsulfate reductase activity|AMP,sulfite:glutathione-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) activity KEGG_REACTION:R05717|MetaCyc:1.8.4.9-RXN|EC:1.8.4.9|RHEA:14141 molecular_function owl:Class
GO:0070680 biolink:NamedThing asparaginyl-tRNAAsn biosynthesis via transamidation A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase. got7fsn_ti mah 2009-06-02T03:11:19Z MetaCyc:PWY490-4 biological_process owl:Class
GO:0004982 biolink:NamedThing N-formyl peptide receptor activity Combining with an N-formyl peptide to initiate a change in cell activity. got7fsn_ti Fmet-leu-phe receptor molecular_function owl:Class
GO:0018054 biolink:NamedThing peptidyl-lysine biotinylation The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine. got7fsn_ti RESID:AA0117 biological_process owl:Class
GO:0033907 biolink:NamedThing beta-D-fucosidase activity Catalysis of the hydrolysis of terminal non-reducing beta-D-fucose residues in beta-D-fucosides. got7fsn_ti beta-D-fucoside fucohydrolase activity|beta-fucosidase activity EC:3.2.1.38|MetaCyc:3.2.1.38-RXN molecular_function owl:Class
GO:0032287 biolink:NamedThing peripheral nervous system myelin maintenance The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state. got7fsn_ti myelin maintenance in peripheral nervous system biological_process owl:Class
GO:0044791 biolink:NamedThing positive regulation by host of viral release from host cell A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells. got7fsn_ti jl 2013-06-06T10:51:48Z biological_process owl:Class
GO:0044794 biolink:NamedThing positive regulation by host of viral process A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected. got7fsn_ti jl 2013-06-06T11:33:51Z biological_process owl:Class
GO:0044181 biolink:NamedThing filamentous growth of a multicellular organism The process in which a multicellular organism grows in a threadlike, filamentous shape. got7fsn_ti jl 2009-09-25T10:17:58Z biological_process owl:Class
GO:0071176 biolink:NamedThing MAML2-RBP-Jkappa-ICN2 complex A protein complex that consists of the intracellular domain of Notch2 (ICN2), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-2 (MAML2); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML2-RBP-Jkappa-Notch2 complex mah 2009-11-23T02:42:24Z cellular_component owl:Class
GO:0062131 biolink:NamedThing 3-butenylglucosinolate 2-hydroxylase activity Catalysis of the reaction: gluconapin + a reduced electron acceptor + O2 = xi-progoitrin + an oxidized electron acceptor + H2O. got7fsn_ti But-3-enyl Glucosinolate-2-hydroxylase activity dph 2019-06-24T16:45:18Z RHEA:60628|MetaCyc:RXNQT-4343 molecular_function owl:Class
GO:0061408 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to heat stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. got7fsn_ti dph 2012-01-12T11:50:30Z biological_process owl:Class
GO:0005539 biolink:NamedThing glycosaminoglycan binding Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. got7fsn_ti molecular_function owl:Class
GO:0061302 biolink:NamedThing smooth muscle cell-matrix adhesion The binding of a smooth muscle cell to the extracellular matrix via adhesion molecules. got7fsn_ti dph 2010-09-14T11:08:00Z biological_process owl:Class
GO:0102518 biolink:NamedThing (11Z)-eicosenoate 14-hydroxylase activity Catalysis of the reaction: (11Z)-eicosenoyl-CoA + NADH + O2 + H+ = lesqueroloyl-CoA + NAD + H2O. got7fsn_ti MetaCyc:RXN-14488|EC:1.14.18.4 molecular_function owl:Class
GO:0033841 biolink:NamedThing 6G-fructosyltransferase activity Catalysis of the reaction: [1-beta-D-fructofuranosyl-(2->1)-]m+1 alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 alpha-D-glucopyranoside = [1-beta-D-fructofuranosyl-(2->1)-]m alpha-D-glucopyranoside + [1-beta-D-fructofuranosyl-(2->1)-]n+1 beta-D-fructofuranosyl-(2->6)-alpha-D-glucopyranoside (m > 0; n >= 0). got7fsn_ti fructan:fructan 6G-fructosyltransferase activity|6G-FT|6G-FFT|6G-fructotransferase activity|1F-oligo[beta-D-fructofuranosyl-(2->1)-]sucrose 6G-beta-D-fructotransferase activity EC:2.4.1.243|MetaCyc:2.4.1.243-RXN molecular_function owl:Class
GO:0034833 biolink:NamedThing geranylate CoA-transferase activity Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-. got7fsn_ti UM-BBD_reactionID:r1165 molecular_function owl:Class
GO:0002160 biolink:NamedThing desmosome maintenance The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm. got7fsn_ti Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. hjd 2010-02-09T10:50:59Z biological_process owl:Class
GO:0051203 biolink:NamedThing peptidyl-aspartic acid reduction to form L-aspartyl aldehyde The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein. got7fsn_ti peptidyl-aspartic acid reduction to form L-aspartate-beta-semialdehyde|peptidyl-aspartic acid reduction to form L-beta-formylalanine See also UniProtKB:P04160. RESID:AA0373 biological_process owl:Class
GO:0051369 biolink:NamedThing peptidyl-threonine decanoylation The decanoylation of peptidyl-threonine to form peptidyl-O3-decanoyl-L-threonine, typical of the protein ghrelin. got7fsn_ti RESID:AA0387 biological_process owl:Class
GO:0061123 biolink:NamedThing negative regulation of positive chemotaxis to cAMP Any process that decreases the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP. got7fsn_ti dph 2010-05-17T08:27:20Z biological_process owl:Class
GO:1990250 biolink:NamedThing transcription-coupled nucleotide-excision repair, DNA damage recognition complex A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex. got7fsn_ti bhm 2013-12-05T16:28:45Z cellular_component owl:Class
GO:1990249 biolink:NamedThing nucleotide-excision repair, DNA damage recognition complex A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex. got7fsn_ti bhm 2013-12-05T16:26:51Z cellular_component owl:Class
GO:0050132 biolink:NamedThing N-methylalanine dehydrogenase activity Catalysis of the reaction: N-methyl-L-alanine + H(2)O + NADP(+) = H(+) + methylammonium + NADPH + pyruvate. got7fsn_ti N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating) EC:1.4.1.17|RHEA:21768|MetaCyc:N-METHYLALANINE-DEHYDROGENASE-RXN|KEGG_REACTION:R01584 molecular_function owl:Class
GO:0036033 biolink:NamedThing mediator complex binding Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. got7fsn_ti bf 2011-10-31T05:09:12Z molecular_function owl:Class
GO:0002565 biolink:NamedThing somatic diversification of immune receptors via gene conversion The process in which immune receptor genes are diversified through gene conversion. got7fsn_ti biological_process owl:Class
GO:0010410 biolink:NamedThing hemicellulose metabolic process The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present. got7fsn_ti hemicellulose metabolism biological_process owl:Class
GO:0008073 biolink:NamedThing ornithine decarboxylase inhibitor activity Binds to and stops, prevents or reduces the activity of ornithine decarboxylase. got7fsn_ti molecular_function owl:Class
GO:0102610 biolink:NamedThing (+)-secoisolariciresinol glucosyltransferase activity Catalysis of the reaction: (+)-secoisolariciresinol + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol monoglucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-15442 molecular_function owl:Class
GO:0052544 biolink:NamedThing defense response by callose deposition in cell wall Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a linear 1,3-beta-d-glucan formed from UDP-glucose and is found in certain plant cell walls. got7fsn_ti cell wall callose deposition during defense response|callose deposition in cell wall during defense response|cell wall callose localization during defense response|callose localization in cell wall during defense response biological_process owl:Class
GO:0031712 biolink:NamedThing B1 bradykinin receptor binding Binding to a B1 bradykinin receptor. got7fsn_ti B1 bradykinin receptor ligand molecular_function owl:Class
GO:0007232 biolink:NamedThing osmosensory signaling pathway via Sho1 osmosensor A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system. got7fsn_ti osmosensory signalling pathway via Sho1 osmosensor|signal transduction during osmotic stress via Sho1 osmosensor biological_process owl:Class
GO:0002206 biolink:NamedThing gene conversion of immunoglobulin genes The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion. got7fsn_ti gene conversion of antibody genes biological_process owl:Class
GO:0050339 biolink:NamedThing thymidine-triphosphatase activity Catalysis of the reaction: dTTP + H2O = dTDP + phosphate. got7fsn_ti dTTP nucleotidohydrolase activity|dTTPase activity|thymidine triphosphate nucleotidohydrolase activity|deoxythymidine-5'-triphosphatase activity EC:3.6.1.39|RHEA:19013|MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN molecular_function owl:Class
GO:0015240 biolink:NamedThing amiloride transmembrane transporter activity Enables the transfer of amiloride from one side of a membrane to the other. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic. got7fsn_ti amiloride transporter activity molecular_function owl:Class
GO:0060225 biolink:NamedThing positive regulation of retinal rod cell fate commitment Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. got7fsn_ti biological_process owl:Class
GO:0033503 biolink:NamedThing HULC complex A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2. got7fsn_ti cellular_component owl:Class
GO:0039013 biolink:NamedThing pronephric distal tubule morphogenesis The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros. got7fsn_ti bf 2010-07-02T09:58:03Z biological_process owl:Class
GO:0001039 biolink:NamedThing RNA polymerase III hybrid type promoter sequence-specific DNA binding Binding to a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene. got7fsn_ti RNA polymerase III hybrid type promoter DNA binding krc 2010-08-23T06:21:24Z GO:0001037 molecular_function owl:Class
GO:0008869 biolink:NamedThing galactonate dehydratase activity Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O. got7fsn_ti D-galactonate dehydrase activity|D-galactonate dehydratase activity|D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)|D-galactonate hydro-lyase activity EC:4.2.1.6|MetaCyc:GALACTONDEHYDRAT-RXN|KEGG_REACTION:R03033|RHEA:18649 molecular_function owl:Class
GO:0097394 biolink:NamedThing telomeric repeat-containing RNA transcription by RNA polymerase II The synthesis of telomeric repeat-containing RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II promoter. got7fsn_ti telomeric RNA transcription from Pol II promoter|TERRA RNA transcription from RNA pol II promoter|telomeric repeat-containing RNA transcription from RNA pol II promoter https://github.com/geneontology/go-ontology/issues/14854 pr 2012-10-23T10:09:15Z biological_process owl:Class
GO:0061109 biolink:NamedThing dense core granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells. got7fsn_ti dense core granule organisation dph 2010-05-01T09:34:37Z biological_process owl:Class
GO:0010910 biolink:NamedThing positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate. got7fsn_ti biological_process owl:Class
GO:0010912 biolink:NamedThing positive regulation of isomerase activity Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. got7fsn_ti biological_process owl:Class
GO:0030772 biolink:NamedThing tryptophan 2-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+). got7fsn_ti tryptophan 2-methyltransferase activity|S-adenosylmethionine:tryptophan 2-methyltransferase activity|S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity EC:2.1.1.106|KEGG_REACTION:R08547|MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN|RHEA:17321 molecular_function owl:Class
GO:0080044 biolink:NamedThing quercetin 7-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 7-hydroxy group of a quercetin molecule. got7fsn_ti molecular_function owl:Class
GO:0046655 biolink:NamedThing folic acid metabolic process The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. got7fsn_ti vitamin M metabolic process|folate metabolic process|vitamin B9 metabolic process|folate metabolism|vitamin M metabolism|vitamin B9 metabolism|folic acid metabolism biological_process owl:Class
GO:0030796 biolink:NamedThing cycloartenol 24-C-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity|sterol C-methyltransferase activity MetaCyc:2.1.1.142-RXN|EC:2.1.1.142|RHEA:13137|KEGG_REACTION:R05760 molecular_function owl:Class
GO:0035937 biolink:NamedThing estrogen secretion The regulated release of estrogen into the circulatory system. Estrogen is a steroid hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals. got7fsn_ti oestrogen secretion bf 2011-07-20T01:14:44Z biological_process owl:Class
GO:0008763 biolink:NamedThing UDP-N-acetylmuramate-L-alanine ligase activity Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine. got7fsn_ti MurC synthetase activity|uridine diphospho-N-acetylmuramoylalanine synthetase activity|UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)|alanine-adding enzyme activity|UDP-N-acetylmuramoylalanine synthetase activity|UDPMurNAc-L-alanine synthetase activity|UDP-N-acetylmuramoyl-L-alanine synthetase activity|L-alanine-adding enzyme activity|L-Ala ligase activity|UDP-MurNAc:L-alanine ligase activity|UDP-acetylmuramyl-L-alanine synthetase activity|uridine diphosphate N-acetylmuramate:L-alanine ligase activity|uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity|UDP-N-acetylmuramyl:L-alanine ligase activity|uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity RHEA:23372|MetaCyc:UDP-NACMUR-ALA-LIG-RXN|EC:6.3.2.8|KEGG_REACTION:R03193 molecular_function owl:Class
GO:0086029 biolink:NamedThing Purkinje myocyte to ventricular cardiac muscle cell signaling Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell. got7fsn_ti Purkinje myocyte to ventricular cardiac muscle cell signalling tb 2011-11-11T02:02:14Z biological_process owl:Class
GO:0019084 biolink:NamedThing middle viral transcription The viral transcription that takes place after early transcription in the viral life cycle, and which involves the transcription of genes required for replication. got7fsn_ti (delayed) early viral mRNA transcription biological_process owl:Class
GO:0010025 biolink:NamedThing wax biosynthetic process The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids. got7fsn_ti wax biosynthesis|wax synthesis|wax formation|wax anabolism MetaCyc:PWY-282 biological_process owl:Class
GO:0031474 biolink:NamedThing myosin IV complex A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV. got7fsn_ti cellular_component owl:Class
GO:0018238 biolink:NamedThing peptidyl-lysine carboxyethylation The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine. got7fsn_ti protein amino acid carboxyethylation GO:0018239 RESID:AA0115 biological_process owl:Class
GO:0004923 biolink:NamedThing leukemia inhibitory factor receptor activity Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti LIF receptor activity|leukemia inhibitory factor receptor beta-protein activity GO:0004899 molecular_function owl:Class
GO:0008941 biolink:NamedThing nitric oxide dioxygenase activity Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+. got7fsn_ti NOD activity|nitric oxide,NAD(P)H:oxygen oxidoreductase activity MetaCyc:R621-RXN|EC:1.14.12.17|Reactome:R-HSA-5340226|Reactome:R-HSA-1222723 molecular_function owl:Class
GO:0001117 biolink:NamedThing protein-DNA-RNA complex disassembly The disaggregation of a protein-DNA-RNA complex into its constituent components. got7fsn_ti krc 2010-12-03T04:04:07Z biological_process owl:Class
GO:0050252 biolink:NamedThing retinol O-fatty-acyltransferase activity Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester. got7fsn_ti acyl-CoA:retinol O-acyltransferase activity|retinol fatty-acyltransferase activity|retinol acyltransferase activity EC:2.3.1.76|MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN|Reactome:R-HSA-8848585|Reactome:R-HSA-2465919|RHEA:11488 molecular_function owl:Class
GO:0018768 biolink:NamedThing 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate. got7fsn_ti UM-BBD_reactionID:r0458|EC:3.7.1.13 molecular_function owl:Class
GO:0072687 biolink:NamedThing meiotic spindle A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle. got7fsn_ti mah 2011-07-08T05:17:08Z cellular_component owl:Class
GO:0055064 biolink:NamedThing chloride ion homeostasis Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0000343 biolink:NamedThing plastid-encoded plastid RNA polymerase complex A A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex. got7fsn_ti PEP-A cellular_component owl:Class
GO:0000427 biolink:NamedThing plastid-encoded plastid RNA polymerase complex An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition. got7fsn_ti cellular_component owl:Class
GO:0102041 biolink:NamedThing 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N-[(7,8-dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid. got7fsn_ti EC:2.5.1.105|MetaCyc:RXN-10009|RHEA:35951 molecular_function owl:Class
GO:0050072 biolink:NamedThing m7G(5')pppN diphosphatase activity Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide. got7fsn_ti M(7)G(5')pppN pyrophosphatase activity|m7G(5')pppN pyrophosphatase activity|decapase activity|7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity EC:3.6.1.30|MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN molecular_function owl:Class
GO:0010242 biolink:NamedThing oxygen evolving activity Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle. got7fsn_ti photosynthetic water oxidation RHEA:36359|MetaCyc:RXN0-5265|EC:1.10.3.9|MetaCyc:PSII-RXN molecular_function owl:Class
GO:0008295 biolink:NamedThing spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. got7fsn_ti spermidine biosynthesis|spermidine formation|spermidine synthesis|spermidine anabolism MetaCyc:BSUBPOLYAMSYN-PWY|MetaCyc:POLYAMINSYN3-PWY biological_process owl:Class
GO:0021817 biolink:NamedThing nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration. got7fsn_ti nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration|nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:0098672 biolink:NamedThing evasion by virus of CRISPR-cas system Any process, either active or passive, by which a virus evades the CRISPR-cas system of its host. Some viruses can directly suppress the CRISPR system. got7fsn_ti CRISPR-cas system evasion by virus dos 2017-01-16T13:38:27Z VZ:3962 biological_process owl:Class
GO:0061483 biolink:NamedThing sulfinylpropanyl adenylate synthase Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H(+) + phosphate. got7fsn_ti SPA synthase dph 2012-11-16T10:08:15Z molecular_function owl:Class
GO:0004512 biolink:NamedThing inositol-3-phosphate synthase activity Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. got7fsn_ti 1L-myo-inositol-1-phosphate lyase (isomerizing)|glucose 6-phosphate cyclase activity|D-glucose 6-phosphate cycloaldolase activity|inositol 1-phosphate synthetase activity|glucose-6-phosphate inositol monophosphate cycloaldolase activity|glucocycloaldolase activity|inositol 1-phosphate synthatase activity Reactome:R-HSA-1855178|EC:5.5.1.4|MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN|KEGG_REACTION:R07324|RHEA:10716 molecular_function owl:Class
GO:0047749 biolink:NamedThing cholestanetriol 26-monooxygenase activity Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + NADPH + O2 = 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NADP+ + H2O. got7fsn_ti cholesterol 27-hydroxylase activity|5beta-cholestane-3alpha,7alpha,12alpha-triol 26-hydroxylase activity|cytochrome P450 27A1' activity|CYP27A|sterol 27-hydroxylase activity|cholestanetriol 26-hydroxylase activity|sterol 26-hydroxylase activity|5beta-cholestane-3alpha,7alpha,12alpha-triol hydroxylase activity|CYP27A1|5beta-cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating)|5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase activity|5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase activity MetaCyc:CHOLESTANETRIOL-26-MONOOXYGENASE-RXN|RHEA:14373|EC:1.14.15.15 molecular_function owl:Class
GO:0051554 biolink:NamedThing flavonol metabolic process The chemical reactions and pathways involving flavonols, a member of a class of vascular pigments formed by consecutive oxidative processes from the flavonoid intermediates flavanones and dihydroflavonols. Flavonols are the most widespread of the flavonoids and have a wide array of physiological activities. got7fsn_ti flavonol metabolism biological_process owl:Class
GO:0035254 biolink:NamedThing glutamate receptor binding Binding to a glutamate receptor. got7fsn_ti molecular_function owl:Class
GO:0034556 biolink:NamedThing nitrobenzoate nitroreductase activity Catalysis of the reaction: o-nitrobenzoate + NADPH + H+ = o-hydroxylaminobenzoate + NADP+. got7fsn_ti EC:1.7.1.-|UM-BBD_reactionID:r0849 molecular_function owl:Class
GO:0052724 biolink:NamedThing inositol hexakisphosphate 3-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate. got7fsn_ti ai 2011-08-16T11:50:48Z EC:2.7.4.21|MetaCyc:RXN-10971 molecular_function owl:Class
GO:0000439 biolink:NamedThing transcription factor TFIIH core complex The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD. got7fsn_ti core TFIIH complex|SSL2-core TFIIH complex GO:0000441 cellular_component owl:Class
GO:0052668 biolink:NamedThing CTP:farnesol kinase activity Catalysis of the reaction: 2-trans,-6-trans-farnesol + CTP = 2-trans,-6-trans-farnesyl monophosphate + CDP + H+. got7fsn_ti CTP:2-trans,-6-trans-farnesol kinase activity|CTP:2-trans,-6-trans-farnesol phosphotransferase activity|farnesol phosphotransferase activity|trans,trans-farnesol kinase activity|farnesol kinase activity https://github.com/geneontology/go-ontology/issues/21619 ai 2011-04-11T01:19:25Z GO:0052669 EC:2.7.1.216|RHEA:51680|MetaCyc:RXN-11625 molecular_function owl:Class
GO:0060111 biolink:NamedThing alae of collagen and cuticulin-based cuticle extracellular matrix Raised, thickened cuticular ridges that run longitudinally, and in parallel, along the left and right sides of the animal. The alae lie above the hypodermal cells known as the lateral seam cells. In C. elegans, alae are produced in L1 larvae, dauer larvae and adult stage animals, where they consist of three, five, and three ridges of distinct morphology, respectively. got7fsn_ti alae of collagen and cuticulin-based exoskeleton extracellular matrix cellular_component owl:Class
GO:0005111 biolink:NamedThing type 2 fibroblast growth factor receptor binding Binding to a type 2 fibroblast growth factor receptor (FGFR2). got7fsn_ti heartless binding|type 2 fibroblast growth factor receptor ligand|heartless ligand|FGFR2 ligand|FGFR2 binding Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2). molecular_function owl:Class
GO:0031701 biolink:NamedThing angiotensin receptor binding Binding to an angiotensin receptor. got7fsn_ti angiotensin receptor ligand molecular_function owl:Class
GO:0071481 biolink:NamedThing cellular response to X-ray Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). got7fsn_ti cellular response to X-ray radiation stimulus mah 2009-12-18T02:00:59Z biological_process owl:Class
GO:0010165 biolink:NamedThing response to X-ray Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz). got7fsn_ti response to X-ray radiation stimulus biological_process owl:Class
GO:1990387 biolink:NamedThing isogloboside biosynthetic process The chemical reactions and pathways resulting in the formation of a lactosyl-ceramide derivative in which a galactose is linked to the galactose via an alpha 1,3 linkage (vs alpha 1,4 for globosides). got7fsn_ti hjd 2014-05-30T17:36:51Z biological_process owl:Class
GO:0006688 biolink:NamedThing glycosphingolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. got7fsn_ti glycosphingolipid biosynthesis|glycosphingolipid formation|glycosphingolipid synthesis|glycosphingolipid anabolism biological_process owl:Class
GO:0050351 biolink:NamedThing trimetaphosphatase activity Catalysis of the reaction: H(2)O + trimetaphosphate = 2 H(+) + triphosphate. got7fsn_ti trimetaphosphate hydrolase activity|inorganic trimetaphosphatase activity KEGG_REACTION:R02504|RHEA:11088|EC:3.6.1.2|MetaCyc:TRIMETAPHOSPHATASE-RXN molecular_function owl:Class
GO:0046694 biolink:NamedThing sperm incapacitation The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males. got7fsn_ti biological_process owl:Class
GO:0034092 biolink:NamedThing negative regulation of maintenance of sister chromatid cohesion Any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained. got7fsn_ti biological_process owl:Class
GO:0042545 biolink:NamedThing cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. got7fsn_ti biological_process owl:Class
GO:0004582 biolink:NamedThing dolichyl-phosphate beta-D-mannosyltransferase activity Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate. got7fsn_ti mannosylphosphodolichol synthase activity|GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity|dolichol-phosphate mannose synthase activity|dolichyl-phosphate mannose synthase activity|GDPmannose:dolichyl-phosphate mannosyltransferase activity|GDP-mannose-dolichol phosphate mannosyltransferase activity|dolichol-phosphate-mannose synthase activity|guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity|GDPmannose-dolichylmonophosphate mannosyltransferase activity|dolichyl phosphate mannosyltransferase activity|dolichol phosphate mannose synthase activity|dolichol-phosphate mannosyltransferase activity|mannosylphosphoryldolichol synthase activity|DPM synthase activity|dolichyl-phospho-mannose synthase activity|dolichyl mannosyl phosphate synthase activity|GDPMan:DolP mannosyltransferase activity Reactome:R-HSA-162721|Reactome:R-HSA-4719354|Reactome:R-HSA-4719375|RHEA:21184|EC:2.4.1.83|MetaCyc:2.4.1.83-RXN|Reactome:R-HSA-4717406 molecular_function owl:Class
GO:0045702 biolink:NamedThing positive regulation of spermatid nuclear differentiation Any process that activates or increases the frequency, rate or extent of spermatid nuclear differentiation. got7fsn_ti stimulation of spermatid nuclear differentiation|upregulation of spermatid nuclear differentiation|up-regulation of spermatid nuclear differentiation|up regulation of spermatid nuclear differentiation|activation of spermatid nuclear differentiation biological_process owl:Class
GO:0098785 biolink:NamedThing biofilm matrix assembly A process that results in the assembly of a biofilm matrix. got7fsn_ti biological_process owl:Class
GO:0052925 biolink:NamedThing dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. got7fsn_ti man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity|dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity RHEA:29527|EC:2.4.1.258|KEGG_REACTION:R06258|MetaCyc:RXN-5466 molecular_function owl:Class
GO:0000033 biolink:NamedThing alpha-1,3-mannosyltransferase activity Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage. got7fsn_ti Reactome:R-HSA-4549368|Reactome:R-HSA-4720473|Reactome:R-HSA-446208|Reactome:R-HSA-446188 molecular_function owl:Class
GO:0047778 biolink:NamedThing [citrate-(pro-3S)-lyase] thiolesterase activity Catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate. got7fsn_ti citrate-(pro-3S)-lyase thioesterase activity|[citrate-(pro-3S)-lyase] thioesterase activity|citrate lyase deacetylase activity|citrate-(pro-3S)-lyase(acetyl-form) hydrolase activity|citrate-(pro-3S)-lyase thiolesterase activity|citrate (pro-3S)-lyase thiolesterase activity MetaCyc:CITRATE-PRO-3S-LYASE-THIOLESTERASE-RXN|EC:3.1.2.16|RHEA:13657 molecular_function owl:Class
GO:0090112 biolink:NamedThing COPII vesicle uncoating The process in which COPII vesicle coat proteins are disassembled, and released. got7fsn_ti tb 2009-12-06T08:56:50Z biological_process owl:Class
GO:0035848 biolink:NamedThing oviduct morphogenesis The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. got7fsn_ti fallopian tube morphogenesis bf 2011-05-10T11:01:20Z biological_process owl:Class
GO:0003215 biolink:NamedThing cardiac right ventricle morphogenesis The process in which the right cardiac ventricle is generated and organized. got7fsn_ti dph 2009-10-13T09:50:57Z biological_process owl:Class
GO:0097661 biolink:NamedThing SCF-Ctf13 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Ctf13 in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:25:56Z cellular_component owl:Class
GO:0016231 biolink:NamedThing beta-N-acetylglucosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides. got7fsn_ti molecular_function owl:Class
GO:0050613 biolink:NamedThing delta14-sterol reductase activity Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. got7fsn_ti sterol C14-reductase activity|D14-sterol reductase activity|C-14 sterol reductase activity|4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity|sterol C-14 reductase activity Note that zymosterol is cholesta-8,24-dien-3-ol. GO:0000251 Reactome:R-HSA-194674|EC:1.3.1.70|RHEA:18561|MetaCyc:1.3.1.70-RXN|Reactome:R-HSA-194698 molecular_function owl:Class
GO:0042652 biolink:NamedThing mitochondrial respiratory chain complex I, peripheral segment The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. got7fsn_ti NADH-Q oxidoreductase complex, peripheral segment|NADH dehydrogenase (ubiquinone) complex, peripheral segment cellular_component owl:Class
GO:1990853 biolink:NamedThing histone H2A SQE motif phosphorylation The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone. got7fsn_ti al 2015-09-15T15:18:02Z biological_process owl:Class
GO:0010435 biolink:NamedThing 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0. got7fsn_ti 3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity|OPC-8:0 CoA ligase activity|3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity EC:6.2.1.-|MetaCyc:RXN-10695 molecular_function owl:Class
GO:0001920 biolink:NamedThing negative regulation of receptor recycling Any process that stops, prevents, or reduces the rate of receptor recycling. got7fsn_ti downregulation of receptor recycling|down-regulation of receptor recycling|down regulation of receptor recycling|inhibition of receptor recycling biological_process owl:Class
GO:0060719 biolink:NamedThing chorionic trophoblast cell development The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. got7fsn_ti dph 2009-06-11T02:58:45Z biological_process owl:Class
GO:0047213 biolink:NamedThing anthocyanidin 3-O-glucosyltransferase activity Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. got7fsn_ti uridine diphosphoglucose-anthocyanidin 3-O-glucosyltransferase activity|UDP-glucose:anthocyanidin 3-O-D-glucosyltransferase activity|UDP-glucose:cyanidin-3-O-glucosyltransferase activity|UDP-glucose:anthocyanidin/flavonol 3-O-glucosyltransferase activity|3-GT activity|UDP-D-glucose:anthocyanidin 3-O-beta-D-glucosyltransferase activity MetaCyc:2.4.1.115-RXN|RHEA:20093|EC:2.4.1.115 molecular_function owl:Class
GO:0140685 biolink:NamedThing histone H3-di/monomethyl-lysine-9 FAD-dependent demethylase activity Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. got7fsn_ti histone H3K9me demethylase activity|histone H3K9me2 demethylase activity https://github.com/geneontology/go-ontology/issues/21089 pg 2021-07-09T07:18:00Z molecular_function owl:Class
GO:0046577 biolink:NamedThing long-chain-alcohol oxidase activity Catalysis of the reaction: 2 long-chain alcohol + O2 = 2 long-chain aldehyde + 2 H2O. got7fsn_ti fatty alcohol oxidase activity|long-chain-alcohol:oxygen oxidoreductase activity|fatty alcohol:oxygen oxidoreductase activity|long-chain fatty acid oxidase activity|long-chain fatty alcohol oxidase activity EC:1.1.3.20|MetaCyc:LONG-CHAIN-ALCOHOL-OXIDASE-RXN|RHEA:22756 molecular_function owl:Class
GO:0018400 biolink:NamedThing peptidyl-proline hydroxylation to 3-hydroxy-L-proline The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase. got7fsn_ti See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'. RESID:AA0029 biological_process owl:Class
GO:0002052 biolink:NamedThing positive regulation of neuroblast proliferation Any process that activates or increases the rate of neuroblast proliferation. got7fsn_ti stimulation of neuroblast proliferation|up-regulation of neuroblast proliferation|up regulation of neuroblast proliferation|upregulation of neuroblast proliferation|activation of neuroblast proliferation biological_process owl:Class
GO:0043023 biolink:NamedThing ribosomal large subunit binding Binding to a large ribosomal subunit. got7fsn_ti molecular_function owl:Class
GO:0039696 biolink:NamedThing RNA-templated viral transcription A transcription process that uses viral RNA as a template. got7fsn_ti bf 2013-10-28T13:28:01Z biological_process owl:Class
GO:0045103 biolink:NamedThing intermediate filament-based process Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins. got7fsn_ti biological_process owl:Class
GO:1990683 biolink:NamedThing DNA double-strand break attachment to nuclear envelope A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs. got7fsn_ti vw 2015-03-10T16:36:21Z biological_process owl:Class
GO:0051880 biolink:NamedThing G-quadruplex DNA binding Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. got7fsn_ti G-DNA binding|G quartet binding|G-quartet DNA binding|G quartet DNA binding|tetraplex DNA binding|G-quartet binding|G quadruplex DNA binding|quadruplex DNA binding molecular_function owl:Class
GO:0000937 biolink:NamedThing dolipore septum A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome). got7fsn_ti cellular_component owl:Class
GO:0000934 biolink:NamedThing porous cell septum A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments. got7fsn_ti porous septum cellular_component owl:Class
GO:0018312 biolink:NamedThing peptidyl-serine ADP-ribosylation The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine. got7fsn_ti RESID:AA0237 biological_process owl:Class
GO:0030093 biolink:NamedThing chloroplast photosystem I Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana. got7fsn_ti cellular_component owl:Class
GO:0061902 biolink:NamedThing negative regulation of 1-phosphatidylinositol-3-kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of 1-phosphatidylinositol-3-kinase activity. got7fsn_ti dph 2017-06-22T19:51:34Z biological_process owl:Class
GO:0006661 biolink:NamedThing phosphatidylinositol biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. got7fsn_ti phosphatidylinositol anabolism|PtdIns biosynthesis|phosphatidylinositol biosynthesis|PtdIns biosynthetic process|phosphoinositide biosynthesis|phosphatidylinositol synthesis|phosphoinositide biosynthetic process|phosphatidylinositol formation GO:0046489 biological_process owl:Class
GO:0019813 biolink:NamedThing type III site-specific deoxyribonuclease complex A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell. got7fsn_ti type III restriction enzyme complex cellular_component owl:Class
NCBITaxon:32524 biolink:NamedThing got7fsn_ti owl:Class
GO:0035240 biolink:NamedThing dopamine binding Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. got7fsn_ti molecular_function owl:Class
GO:1905788 biolink:NamedThing negative regulation of detection of mechanical stimulus involved in sensory perception of touch Any process that stops, prevents or reduces the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. got7fsn_ti down regulation of perception of touch, sensory detection of mechanical stimulus|down-regulation of perception of touch, sensory transduction of mechanical stimulus|downregulation of detection of mechanical stimulus involved in sensory perception of touch|downregulation of perception of touch, sensory transduction of mechanical stimulus|inhibition of tactition, sensory detection of mechanical stimulus|downregulation of sensory detection of mechanical stimulus during perception of touch|down regulation of tactition, sensory detection of mechanical stimulus|negative regulation of sensory transduction of mechanical stimulus during perception of touch|downregulation of perception of touch, detection of mechanical stimulus|inhibition of detection of mechanical stimulus involved in sensory perception of touch|negative regulation of sensory detection of mechanical stimulus during perception of touch|inhibition of perception of touch, sensory detection of mechanical stimulus|down-regulation of sensory detection of mechanical stimulus during perception of touch|negative regulation of perception of touch, detection of mechanical stimulus|inhibition of sensory detection of mechanical stimulus during perception of touch|inhibition of perception of touch, detection of mechanical stimulus|down regulation of perception of touch, detection of mechanical stimulus|downregulation of perception of touch, sensory detection of mechanical stimulus|down-regulation of perception of touch, detection of mechanical stimulus|down regulation of perception of touch, sensory transduction of mechanical stimulus|down-regulation of tactition, sensory detection of mechanical stimulus|negative regulation of tactition, sensory detection of mechanical stimulus|negative regulation of perception of touch, sensory transduction of mechanical stimulus|down regulation of sensory detection of mechanical stimulus during perception of touch|down regulation of detection of mechanical stimulus involved in sensory perception of touch|down-regulation of perception of touch, sensory detection of mechanical stimulus|down-regulation of sensory transduction of mechanical stimulus during perception of touch|downregulation of tactition, sensory detection of mechanical stimulus|down regulation of sensory transduction of mechanical stimulus during perception of touch|inhibition of sensory transduction of mechanical stimulus during perception of touch|down-regulation of detection of mechanical stimulus involved in sensory perception of touch|downregulation of sensory transduction of mechanical stimulus during perception of touch|negative regulation of perception of touch, sensory detection of mechanical stimulus|inhibition of perception of touch, sensory transduction of mechanical stimulus hbye 2017-01-09T15:11:14Z biological_process owl:Class
GO:0009788 biolink:NamedThing negative regulation of abscisic acid-activated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling. got7fsn_ti inhibition of abscisic acid mediated signaling|down-regulation of abscisic acid mediated signaling|negative regulation of abscisic acid mediated signalling|negative regulation of abscisic acid mediated signaling pathway|down regulation of abscisic acid mediated signaling|downregulation of abscisic acid mediated signaling biological_process owl:Class
GO:1905909 biolink:NamedThing regulation of dauer entry Any process that modulates the frequency, rate or extent of dauer entry. got7fsn_ti regulation of nematode entry into dormancy hbye 2017-02-06T15:34:01Z biological_process owl:Class
GO:1904655 biolink:NamedThing positive regulation of lung alveolus development Any process that activates or increases the frequency, rate or extent of lung alveolus development. got7fsn_ti positive regulation of alveolarization|upregulation of alveolarization|up-regulation of alveolarization|up regulation of alveolarization|up-regulation of lung alveolus development|up regulation of alveologenesis|up regulation of lung alveolus development|activation of lung alveolus development|activation of alveologenesis|upregulation of lung alveolus development|activation of alveolarization|up-regulation of alveologenesis|upregulation of alveologenesis|positive regulation of alveologenesis sl 2015-09-03T22:44:56Z biological_process owl:Class
GO:1901474 biolink:NamedThing azole transmembrane transporter activity Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other. got7fsn_ti azole transporter activity tb 2012-10-04T20:00:27Z GO:0045118 molecular_function owl:Class
GO:0045117 biolink:NamedThing azole transmembrane transport The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane. got7fsn_ti azole transport biological_process owl:Class
GO:0061267 biolink:NamedThing mesonephric interstitial fibroblast development The process whose specific outcome is the progression of a mesonephric interstitial fibroblast over time, from its formation to the mature structure. got7fsn_ti mesonephros interstitial cell development dph 2010-08-30T03:14:31Z biological_process owl:Class
GO:1903904 biolink:NamedThing negative regulation of establishment of T cell polarity Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity. got7fsn_ti downregulation of T-cell polarization|downregulation of T lymphocyte polarization|inhibition of T-cell polarization|inhibition of establishment of T-lymphocyte polarity|downregulation of establishment of T-lymphocyte polarity|downregulation of T cell polarization|negative regulation of T cell polarization|down regulation of establishment of T-cell polarity|down-regulation of establishment of T-cell polarity|down-regulation of T-cell polarization|negative regulation of T-cell polarization|negative regulation of T lymphocyte polarization|down-regulation of establishment of T-lymphocyte polarity|down regulation of establishment of T lymphocyte polarity|down regulation of establishment of T cell polarity|downregulation of establishment of T lymphocyte polarity|negative regulation of establishment of T lymphocyte polarity|down regulation of T cell polarization|inhibition of establishment of T-cell polarity|down regulation of T lymphocyte polarization|downregulation of establishment of T cell polarity|inhibition of T lymphocyte polarization|down regulation of T-cell polarization|down-regulation of establishment of T cell polarity|inhibition of T cell polarization|down regulation of establishment of T-lymphocyte polarity|negative regulation of establishment of T-cell polarity|down-regulation of T lymphocyte polarization|down-regulation of T cell polarization|downregulation of establishment of T-cell polarity|inhibition of establishment of T cell polarity|inhibition of establishment of T lymphocyte polarity|down-regulation of establishment of T lymphocyte polarity|negative regulation of establishment of T-lymphocyte polarity als 2015-02-09T10:50:30Z biological_process owl:Class
SO:0000275 biolink:NamedThing got7fsn_ti owl:Class
GO:0021860 biolink:NamedThing pyramidal neuron development The progression of a pyramidal neuron from its initial formation to its mature state. got7fsn_ti projection neuron development biological_process owl:Class
GO:0044691 biolink:NamedThing tooth eruption The tooth development process in which the teeth enter the mouth and become visible. got7fsn_ti jl 2012-08-15T14:58:17Z Wikipedia:Tooth_eruption biological_process owl:Class
GO:0035849 biolink:NamedThing nephric duct elongation The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney. got7fsn_ti bf 2011-05-11T11:31:39Z biological_process owl:Class
GO:0061449 biolink:NamedThing olfactory bulb tufted cell development The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti dph 2012-05-15T12:30:21Z biological_process owl:Class
GO:0099502 biolink:NamedThing calcium-dependent activation of synaptic vesicle fusion The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. got7fsn_ti biological_process owl:Class
GO:0003324 biolink:NamedThing pancreatic D cell development The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin. got7fsn_ti pancreatic delta cell development dph 2009-11-02T08:23:26Z biological_process owl:Class
GO:0071068 biolink:NamedThing alpha9-beta1 integrin-ADAM12 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM12. got7fsn_ti ITGA9-ITGB1-ADAM12 complex mah 2009-11-03T04:05:15Z cellular_component owl:Class
GO:0015653 biolink:NamedThing glycine betaine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in). got7fsn_ti glycine betaine:hydrogen symporter activity molecular_function owl:Class
GO:0031460 biolink:NamedThing glycine betaine transport The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti N-trimethylglycine transport biological_process owl:Class
GO:0014004 biolink:NamedThing microglia differentiation The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system. got7fsn_ti microglial cell differentiation biological_process owl:Class
GO:0021921 biolink:NamedThing regulation of cell proliferation in dorsal spinal cord The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord. got7fsn_ti biological_process owl:Class
GO:0009343 biolink:NamedThing biotin carboxylase complex An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2). got7fsn_ti cellular_component owl:Class
GO:0043598 biolink:NamedThing cytoplasmic DNA replication factor C complex A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species. got7fsn_ti cytoplasmic RFC|cytoplasmic clamp loader cellular_component owl:Class
GO:1904512 biolink:NamedThing regulation of initiation of premeiotic DNA replication Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication. got7fsn_ti regulation of premeiotic DNA replication initiation|regulation of initiation of meiotic DNA synthesis|regulation of meiotic DNA replication initiation|regulation of initiation of premeiotic DNA synthesis mah 2015-07-28T12:59:17Z biological_process owl:Class
GO:0048142 biolink:NamedThing germarium-derived cystoblast division The four rounds of incomplete mitosis undergone by a cystoblast to form a 16-cell cyst of interconnected cells within a germarium. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this process is found in Drosophila melanogaster. got7fsn_ti germarium-derived cystoblast cell division biological_process owl:Class
GO:0061400 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to calcium ion Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus. got7fsn_ti dph 2012-01-10T09:36:02Z biological_process owl:Class
GO:0071277 biolink:NamedThing cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. got7fsn_ti cellular response to Ca2+ ion mah 2009-12-10T03:55:01Z biological_process owl:Class
GO:1903952 biolink:NamedThing regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. got7fsn_ti regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization nc 2015-02-24T10:32:06Z biological_process owl:Class
GO:0086013 biolink:NamedThing membrane repolarization during cardiac muscle cell action potential The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. got7fsn_ti tb 2011-11-10T08:23:25Z biological_process owl:Class
GO:0072305 biolink:NamedThing negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. got7fsn_ti negative regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis mah 2010-04-09T05:03:41Z biological_process owl:Class
GO:1905422 biolink:NamedThing negative regulation of plant organ morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of plant organ morphogenesis. got7fsn_ti down regulation of plant organ morphogenesis|down-regulation of plant organ morphogenesis|inhibition of plant organ morphogenesis|downregulation of plant organ morphogenesis tb 2016-09-06T23:00:22Z biological_process owl:Class
GO:0010127 biolink:NamedThing mycothiol-dependent detoxification The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell. got7fsn_ti mycothiol-dependent detoxification of alkylating agent MetaCyc:PWY1G-170|MetaCyc:PWY1G-1 biological_process owl:Class
GO:0061004 biolink:NamedThing pattern specification involved in kidney development Any developmental process that results in the creation of defined areas or spaces within the kidney to which cells respond and eventually are instructed to differentiate. got7fsn_ti pattern formation involved in kidney development|kidney pattern formation|kidney pattern specification dph 2010-01-21T09:05:54Z biological_process owl:Class
GO:0015200 biolink:NamedThing methylammonium transmembrane transporter activity Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0072489 biolink:NamedThing methylammonium transmembrane transport The process in which methylammonium is transported across a membrane. got7fsn_ti methylammonium membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-12-10T10:36:33Z biological_process owl:Class
GO:1905350 biolink:NamedThing Y-shaped link assembly The aggregation, arrangement and bonding together of a set of components to form a Y-shaped link. Two distinct protein complexes are known to be involved in proper linker assembly: the MKS complex and the NPHP complex. Improper assembly of Y-shaped links may cause malfunctioning of the transition zone as a molecular gate. got7fsn_ti membrane-microtubule complex formation|Y-shaped fibre assembly|Y-shaped linker assembly|Y-link assembly|Y-shaped link formation|Y-shaped fiber formation|membrane-microtubule complex assembly|Y-shaped fibre formation|Y-link structure assembly|Y-shaped assemblage assembly|Y-shaped linker formation|Y-link formation|Y-shaped assemblage formation|Y-shaped fiber assembly|Y-link structure formation pr 2016-08-04T16:04:26Z biological_process owl:Class
GO:1903205 biolink:NamedThing regulation of hydrogen peroxide-induced cell death Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death. got7fsn_ti regulation of cell death in response to H2O2|protection against hydrogen peroxide-mediated cell death|regulation of cell death in response to hydrogen peroxide|regulation of hydrogen peroxide-mediated cell death bf 2014-07-21T16:21:47Z biological_process owl:Class
GO:0035277 biolink:NamedThing spiracle morphogenesis, open tracheal system The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk. got7fsn_ti spiracle morphogenesis biological_process owl:Class
GO:0003323 biolink:NamedThing type B pancreatic cell development The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. got7fsn_ti pancreatic B cell development|pancreatic beta cell development dph 2009-11-02T08:20:11Z biological_process owl:Class
GO:0003309 biolink:NamedThing type B pancreatic cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. got7fsn_ti pancreatic B cell differentiation|pancreatic beta cell differentiation dph 2009-10-26T09:27:23Z biological_process owl:Class
GO:0015130 biolink:NamedThing mevalonate transmembrane transporter activity Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds. got7fsn_ti monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity molecular_function owl:Class
GO:0015728 biolink:NamedThing mevalonate transport The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1905757 biolink:NamedThing negative regulation of primary cell septum biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of primary cell septum biogenesis. got7fsn_ti vw 2016-12-12T18:09:59Z biological_process owl:Class
GO:0080153 biolink:NamedThing negative regulation of reductive pentose-phosphate cycle Any process that stops, prevents, or reduces the frequency, rate or extent of the reductive pentose-phosphate cycle. got7fsn_ti negative regulation of C3 photosynthesis|negative regulation of Calvin cycle dhl 2010-07-01T02:55:27Z biological_process owl:Class
GO:0014860 biolink:NamedThing neurotransmitter secretion involved in regulation of skeletal muscle contraction The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. got7fsn_ti neurotransmitter secretion involved in control of skeletal muscle contraction biological_process owl:Class
GO:0072108 biolink:NamedThing positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Any process that increases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. got7fsn_ti mah 2010-02-12T02:45:57Z biological_process owl:Class
UBERON:0000160 biolink:NamedThing got7fsn_ti owl:Class
GO:0002914 biolink:NamedThing regulation of central B cell anergy Any process that modulates the frequency, rate, or extent of central B cell anergy. got7fsn_ti biological_process owl:Class
GO:0097728 biolink:NamedThing 9+0 motile cilium A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). got7fsn_ti motile 9+0 cilium|nodal cilium This type of cilia may be present in solitary (classic nodal cilia in embryonic nodes) or in multiple copies (e.g. in the choroid plexus epithelium). pr 2016-09-27T15:24:37Z cellular_component owl:Class
GO:0031901 biolink:NamedThing early endosome membrane The lipid bilayer surrounding an early endosome. got7fsn_ti cellular_component owl:Class
GO:0038114 biolink:NamedThing interleukin-21-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-21-mediated signaling pathway|interleukin-21-mediated signalling pathway bf 2012-03-22T10:21:01Z biological_process owl:Class
GO:0098757 biolink:NamedThing cellular response to interleukin-21 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus. got7fsn_ti cellular response to IL-21 biological_process owl:Class
GO:2000200 biolink:NamedThing regulation of ribosomal subunit export from nucleus Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus. got7fsn_ti regulation of ribosome export from nucleus|regulation of ribosomal subunit export from cell nucleus|regulation of ribosomal subunit transport from nucleus to cytoplasm|regulation of ribosomal subunit export out of nucleus|regulation of ribosomal subunit-nucleus export mah 2010-10-26T10:44:27Z biological_process owl:Class
CL:0000545 biolink:NamedThing got7fsn_ti owl:Class
GO:1900437 biolink:NamedThing regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus Any process that modulates the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. got7fsn_ti di 2012-04-25T05:55:17Z biological_process owl:Class
GO:0031313 biolink:NamedThing extrinsic component of endosome membrane The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to endosome membrane cellular_component owl:Class
GO:2000554 biolink:NamedThing regulation of T-helper 1 cell cytokine production Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production. got7fsn_ti regulation of Th1 cell cytokine production ebc 2011-04-03T07:35:43Z biological_process owl:Class
GO:1905426 biolink:NamedThing positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation. got7fsn_ti positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|upregulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt signaling pathway involved in mDA neuron differentiation|upregulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|up regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wg signalling pathway involved in mDA neuron differentiation|up regulation of frizzled signalling pathway involved in mDA neuron differentiation|activation of frizzled signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|up regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|up regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|upregulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt-mediated midbrain DA neuron differentiation|positive regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|upregulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|positive regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt signaling pathway involved in mDA neuron differentiation|positive regulation of Wingless signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|activation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wg signalling pathway involved in midbrain DA neurogenesis|upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|up regulation of frizzled signaling pathway involved in mDA neuron differentiation|positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wg signalling pathway involved in mDA neuron differentiation|upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|up regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wingless signalling pathway involved in mDA neuron differentiation|activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of frizzled signalling pathway involved in mDA neuron differentiation|positive regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wingless signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|up-regulation of Wingless signaling pathway involved in mDA neuron differentiation|upregulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|activation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wg signaling pathway involved in mDA neuron differentiation|upregulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wingless signaling pathway involved in mDA neuron differentiation|activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|up regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|activation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt receptor signalling pathway involved in mDA neuron differentiation|positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wg signaling pathway involved in mDA neuron differentiation|activation of Wnt signaling pathway involved in midbrain DA neurogenesis|up-regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wg signalling pathway involved in midbrain DA neurogenesis|upregulation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|upregulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wingless signaling pathway involved in midbrain DA neurogenesis|upregulation of frizzled signaling pathway involved in midbrain DA neurogenesis|up regulation of Wnt-activated signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|up-regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|up regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|activation of Wg signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt-mediated midbrain DA neuron differentiation|up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|activation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of frizzled signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wg signaling pathway involved in mDA neuron differentiation|activation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|up-regulation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|activation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt signaling pathway involved in mDA neuron differentiation|activation of Wnt-activated signaling pathway involved in mDA neuron differentiation|positive regulation of frizzled signalling pathway involved in midbrain DA neurogenesis|upregulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|up regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wg signalling pathway involved in mDA neuron differentiation|positive regulation of Wg signalling pathway involved in mDA neuron differentiation|activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wg signaling pathway involved in mDA neuron differentiation|upregulation of Wingless signaling pathway involved in mDA neuron differentiation|activation of Wg signalling pathway involved in midbrain DA neurogenesis|positive regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|activation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt-mediated midbrain DA neuron differentiation|positive regulation of Wingless signalling pathway involved in mDA neuron differentiation|positive regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of frizzled signaling pathway involved in mDA neuron differentiation|activation of frizzled signalling pathway involved in midbrain dopaminergic neuron production|up-regulation of frizzled signaling pathway involved in mDA neuron differentiation|up regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|up-regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|up-regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|upregulation of Wnt-activated signaling pathway involved in mDA neuron differentiation|activation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of frizzled signalling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wnt signaling pathway involved in mDA neuron differentiation|activation of Wingless signaling pathway involved in midbrain DA neurogenesis|up regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|activation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wg signalling pathway involved in midbrain DA neurogenesis|activation of Wingless signaling pathway involved in mDA neuron differentiation|upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt-mediated midbrain DA neuron differentiation|positive regulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wg signalling pathway involved in mDA neuron differentiation|up regulation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wingless signalling pathway involved in mDA neuron differentiation|up-regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wnt receptor signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wingless signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wg signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wg signaling pathway involved in midbrain DA neurogenesis|up regulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wg signaling pathway involved in midbrain DA neurogenesis|activation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|upregulation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wingless signalling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|up regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|activation of Wg signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wg signalling pathway involved in midbrain dopaminergic neuron production|up regulation of Wingless signalling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wnt receptor signalling pathway involved in mDA neuron differentiation|positive regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of Wnt receptor signalling pathway involved in midbrain DA neurogenesis|positive regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|activation of frizzled signaling pathway involved in midbrain dopaminergic neuron production|activation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wnt-mediated midbrain DA neuron differentiation|positive regulation of Wg signalling pathway involved in midbrain dopaminergic neuron production|upregulation of frizzled signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wingless signalling pathway involved in mDA neuron differentiation|up regulation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|up-regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of frizzled signaling pathway involved in mDA neuron differentiation|upregulation of Wingless signalling pathway involved in midbrain DA neurogenesis|activation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|positive regulation of Wnt signaling pathway involved in DA neurogenesis from midbrain floor plate|activation of frizzled signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt receptor signaling pathway involved in mDA neuron differentiation|up regulation of frizzled signaling pathway involved in DA neurogenesis from midbrain floor plate|upregulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wnt receptor signaling pathway involved in mDA neuron differentiation|up regulation of Wg signaling pathway involved in mDA neuron differentiation|up regulation of Wg signaling pathway involved in midbrain DA neurogenesis|up regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of frizzled signalling pathway involved in mDA neuron differentiation|up regulation of Wnt receptor signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt receptor signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt signaling pathway involved in mDA neuron differentiation|positive regulation of Wg signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wg signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wingless signalling pathway involved in mDA neuron differentiation|up-regulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|positive regulation of Wingless signaling pathway involved in mDA neuron differentiation|upregulation of Wnt signaling pathway involved in midbrain DA neurogenesis|positive regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron differentiation|up-regulation of Wnt signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of frizzled signalling pathway involved in mDA neuron differentiation|positive regulation of midbrain dopaminergic neuron differentiation by positive regulation of Wnt signaling|up regulation of Wnt signaling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt-activated signaling pathway involved in midbrain DA neurogenesis|activation of frizzled signaling pathway involved in mDA neuron differentiation|up regulation of Wingless signaling pathway involved in midbrain dopaminergic neuron differentiation|activation of Wingless signalling pathway involved in midbrain dopaminergic neuron differentiation|upregulation of Wg signalling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|up-regulation of Wg signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt receptor signaling pathway involved in midbrain dopaminergic neuron production|upregulation of Wnt receptor signalling pathway involved in midbrain dopaminergic neuron differentiation|activation of frizzled signalling pathway involved in midbrain DA neurogenesis|up-regulation of Wnt-activated signaling pathway involved in midbrain dopaminergic neuron differentiation|up regulation of Wingless signaling pathway involved in DA neurogenesis from midbrain floor plate|positive regulation of frizzled signalling pathway involved in mDA neuron differentiation bf 2016-09-07T10:03:51Z biological_process owl:Class
GO:0030145 biolink:NamedThing manganese ion binding Binding to a manganese ion (Mn). got7fsn_ti Mn binding|manganese binding molecular_function owl:Class
GO:0004967 biolink:NamedThing glucagon receptor activity Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti molecular_function owl:Class
GO:0071377 biolink:NamedThing cellular response to glucagon stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus. got7fsn_ti mah 2009-12-11T03:25:07Z biological_process owl:Class
GO:0009509 biolink:NamedThing chromoplast A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments. got7fsn_ti Wikipedia:Chromoplast cellular_component owl:Class
GO:0090422 biolink:NamedThing thiamine pyrophosphate transmembrane transporter activity Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other. got7fsn_ti thiamine pyrophosphate transporter activity|thiamine diphosphate transporter activity tb 2012-04-17T12:28:11Z Reactome:R-HSA-8875838 molecular_function owl:Class
GO:0030974 biolink:NamedThing thiamine pyrophosphate transmembrane transport The process in which thiamine pyrophosphate is transported across a membrane. got7fsn_ti thiamine pyrophosphate transport|thiamine diphosphate transport|thiamin diphosphate transport|thiamin pyrophosphate transport|TPP transport biological_process owl:Class
GO:0006649 biolink:NamedThing phospholipid transfer to membrane The transfer of a phospholipid from its site of synthesis to the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0060034 biolink:NamedThing notochord cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate. got7fsn_ti biological_process owl:Class
GO:0099622 biolink:NamedThing cardiac muscle cell membrane repolarization The process in which ions are transported across the plasma membrane of a cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential. got7fsn_ti biological_process owl:Class
GO:0044640 biolink:NamedThing envenomation resulting in negative regulation of complement activation, lectin pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism. got7fsn_ti jl 2012-07-05T04:56:30Z biological_process owl:Class
GO:0097497 biolink:NamedThing blood vessel endothelial cell delamination The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet. got7fsn_ti pr 2013-08-12T13:48:34Z biological_process owl:Class
GO:1990417 biolink:NamedThing snoRNA release from pre-rRNA The release of snoRNA from pre-rRNA. got7fsn_ti An example of this process is yeast HAS1 from PMID:16908538, inferred from mutant phenotype assay. rb 2014-07-11T21:43:27Z biological_process owl:Class
GO:0032474 biolink:NamedThing otolith morphogenesis The process in which the anatomical structures of an otolith are generated and organized. got7fsn_ti biological_process owl:Class
GO:0006264 biolink:NamedThing mitochondrial DNA replication The process in which new strands of DNA are synthesized in the mitochondrion. got7fsn_ti mitochondrial DNA synthesis|mtDNA replication|replication of mitochondrial DNA|mtDNA synthesis biological_process owl:Class
GO:0039007 biolink:NamedThing pronephric nephron morphogenesis The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros. got7fsn_ti bf 2010-07-02T09:38:53Z biological_process owl:Class
GO:0003896 biolink:NamedThing DNA primase activity Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. got7fsn_ti GO:0003897|GO:0003898 EC:2.7.7.101 molecular_function owl:Class
GO:0021841 biolink:NamedThing chemoattraction involved in interneuron migration from the subpallium to the cortex The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex. got7fsn_ti positive chemotaxis involved in interneuron migration from the subpallium to the cortex biological_process owl:Class
GO:0097613 biolink:NamedThing dinoflagellate epicone The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum. got7fsn_ti episome|epicone|epitheca The term name refers to a taxonomic group to make the label unique with respect to similarly-named anatomical structures. pr 2014-06-09T11:32:48Z cellular_component owl:Class
GO:1905934 biolink:NamedThing negative regulation of cell fate determination Any process that stops, prevents or reduces the frequency, rate or extent of cell fate determination. got7fsn_ti down regulation of cell fate determination|down-regulation of cell fate determination|inhibition of cell fate determination|downregulation of cell fate determination bhm 2017-02-09T11:25:30Z biological_process owl:Class
GO:0021815 biolink:NamedThing modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration. got7fsn_ti modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:0008584 biolink:NamedThing male gonad development The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. got7fsn_ti testicular development|testis development biological_process owl:Class
GO:0012510 biolink:NamedThing trans-Golgi network transport vesicle membrane The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. got7fsn_ti trans-Golgi network constitutive secretory pathway transport vesicle membrane|TGN transport vesicle membrane cellular_component owl:Class
GO:0030140 biolink:NamedThing trans-Golgi network transport vesicle A vesicle that mediates transport between the trans-Golgi network and other parts of the cell. got7fsn_ti trans-Golgi network constitutive secretory pathway transport vesicle|TGN transport vesicle cellular_component owl:Class
GO:0090006 biolink:NamedThing regulation of linear element assembly Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase. got7fsn_ti regulation of linear element assembly tb 2009-07-17T01:05:13Z biological_process owl:Class
GO:0051232 biolink:NamedThing meiotic spindle elongation The lengthening of the distance between poles of the spindle during a meiotic cell cycle. got7fsn_ti spindle elongation during meiosis biological_process owl:Class
GO:0060302 biolink:NamedThing negative regulation of cytokine activity Any process that decreases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells. got7fsn_ti biological_process owl:Class
GO:0007182 biolink:NamedThing common-partner SMAD protein phosphorylation The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus. got7fsn_ti common-mediator SMAD protein phosphorylation|common partner SMAD protein phosphorylation|common mediator SMAD protein phosphorylation|co-SMAD protein phosphorylation biological_process owl:Class
GO:1905910 biolink:NamedThing negative regulation of dauer entry Any process that stops, prevents or reduces the frequency, rate or extent of dauer entry. got7fsn_ti down-regulation of dauer entry|downregulation of dauer entry|down regulation of dauer entry|down regulation of nematode entry into dormancy|inhibition of dauer entry|downregulation of nematode entry into dormancy|inhibition of nematode entry into dormancy|down-regulation of nematode entry into dormancy|negative regulation of nematode entry into dormancy hbye 2017-02-06T15:34:11Z biological_process owl:Class
GO:0008429 biolink:NamedThing phosphatidylethanolamine binding Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. got7fsn_ti molecular_function owl:Class
GO:0098866 biolink:NamedThing multivesicular body fusion to apical plasma membrane The fusion of the membrane of a multivesicular body with the apical plasma membrane, resulting in release of exosomes from the cell. got7fsn_ti biological_process owl:Class
GO:0060441 biolink:NamedThing epithelial tube branching involved in lung morphogenesis The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. got7fsn_ti lung branching morphogenesis biological_process owl:Class
GO:0002633 biolink:NamedThing positive regulation of granuloma formation Any process that activates or increases the frequency, rate, or extent of granuloma formation. got7fsn_ti up-regulation of granuloma formation|upregulation of granuloma formation|activation of granuloma formation|stimulation of granuloma formation|up regulation of granuloma formation biological_process owl:Class
GO:0000802 biolink:NamedThing transverse filament A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them. got7fsn_ti cellular_component owl:Class
GO:1905951 biolink:NamedThing mitochondrion DNA recombination Any DNA recombination that takes place in mitochondrion. got7fsn_ti DNA recombination in mitochondria vw 2017-02-19T10:48:17Z biological_process owl:Class
GO:0097195 biolink:NamedThing pilomotor reflex The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect. got7fsn_ti goosebump reflex|piloerection|horripilation pr 2011-12-01T05:08:14Z biological_process owl:Class
GO:1990463 biolink:NamedThing lateral cortical node A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins. got7fsn_ti Skb1-containing cortical node pr 2014-08-20T09:04:45Z cellular_component owl:Class
GO:0061405 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it. got7fsn_ti dph 2012-01-10T03:24:51Z biological_process owl:Class
GO:0061043 biolink:NamedThing regulation of vascular wound healing Any process that modulates the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. got7fsn_ti dph 2010-02-25T10:21:59Z biological_process owl:Class
GO:0060316 biolink:NamedThing positive regulation of ryanodine-sensitive calcium-release channel activity Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti biological_process owl:Class
GO:0048447 biolink:NamedThing sepal morphogenesis The process in which the anatomical structures of the sepal are generated and organized. got7fsn_ti GO:0048422 biological_process owl:Class
GO:1902417 biolink:NamedThing (+)-abscisic acid D-glucopyranosyl ester transmembrane transporter activity Enables the transfer of (+)-abscisic acid D-glucopyranosyl ester from one side of a membrane to the other. got7fsn_ti ABA-GE transmembrane transporter activity|abscisic acid glucosyl ester transmembrane transporter activity tb 2013-09-16T22:37:11Z molecular_function owl:Class
GO:1902418 biolink:NamedThing (+)-abscisic acid D-glucopyranosyl ester transmembrane transport The process in which (+)-abscisic acid D-glucopyranosyl este is transported across a membrane. got7fsn_ti abscisic acid glucosyl ester transmembrane transport|ABA-GE transmembrane transport tb 2013-09-16T22:37:20Z biological_process owl:Class
GO:0015208 biolink:NamedThing guanine transmembrane transporter activity Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0002555 biolink:NamedThing histamine secretion by platelet The regulated release of histamine by a platelet or group of platelets. got7fsn_ti biological_process owl:Class
GO:0051208 biolink:NamedThing sequestering of calcium ion The process of binding or confining calcium ions such that they are separated from other components of a biological system. got7fsn_ti calcium ion storage activity|sequestering of calcium ion (Ca2+)|calcium ion (Ca2+) storage|calcium ion (Ca2+) sequestration|negative regulation of calcium ion (Ca2+) transport|storage of calcium ion (Ca2+)|calcium ion (Ca2+) retention|retention of calcium ion (Ca2+)|calcium ion (Ca2+) sequestering|sequestration of calcium ion (Ca2+) biological_process owl:Class
GO:0036316 biolink:NamedThing SREBP-SCAP complex retention in endoplasmic reticulum Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER. got7fsn_ti Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937. bf 2012-08-21T14:53:08Z biological_process owl:Class
GO:0036315 biolink:NamedThing cellular response to sterol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus. got7fsn_ti bf 2012-08-21T14:51:21Z biological_process owl:Class
GO:0016519 biolink:NamedThing gastric inhibitory peptide receptor activity Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein. got7fsn_ti GIP receptor activity|glucose-dependent insulinotropic polypeptide receptor activity molecular_function owl:Class
GO:0044612 biolink:NamedThing nuclear pore linkers A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p). got7fsn_ti Nup82 complex|Nic96 complex jl 2012-06-20T01:22:40Z cellular_component owl:Class
GO:0001518 biolink:NamedThing voltage-gated sodium channel complex A sodium channel in a cell membrane whose opening is governed by the membrane potential. got7fsn_ti voltage-dependent sodium channel complex|voltage-sensitive sodium channel complex|voltage gated sodium channel complex NIF_Subcellular:sao785001660 cellular_component owl:Class
PR:000035728 biolink:NamedThing got7fsn_ti owl:Class
GO:0060023 biolink:NamedThing soft palate development The biological process whose specific outcome is the progression of the soft palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The soft palate is the posterior portion of the palate extending from the posterior edge of the hard palate. got7fsn_ti palatum molle development|velum palatum development biological_process owl:Class
GO:0003810 biolink:NamedThing protein-glutamine gamma-glutamyltransferase activity Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. got7fsn_ti glutaminylpeptide gamma-glutamyltransferase activity|protein-glutamine:amine gamma-glutamyltransferase|factor XIIIa|R-glutaminyl-peptide:amine gamma-glutamyl transferase activity|polyamine transglutaminase activity|tissue transglutaminase|transglutaminase activity|TGase activity|fibrinoligase activity|fibrin stabilizing factor RHEA:54816|MetaCyc:2.3.2.13-RXN|Reactome:R-HSA-6810894|Reactome:R-HSA-140851|RESID:AA0124|EC:2.3.2.13 molecular_function owl:Class
GO:0061076 biolink:NamedThing negative regulation of neural retina development Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells. got7fsn_ti dph 2010-03-16T12:46:11Z biological_process owl:Class
GO:0021682 biolink:NamedThing nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state. got7fsn_ti biological_process owl:Class
GO:0003404 biolink:NamedThing optic vesicle morphogenesis The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup. got7fsn_ti dph 2009-12-21T01:54:34Z biological_process owl:Class
CL:0000236 biolink:NamedThing got7fsn_ti owl:Class
GO:0120207 biolink:NamedThing endocytosis, site selection The process of selecting and or marking the position where endocytosis will occur. got7fsn_ti krc 2019-05-15T21:25:49Z biological_process owl:Class
GO:0015763 biolink:NamedThing N-acetylgalactosamine transport The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine. got7fsn_ti biological_process owl:Class
GO:0009349 biolink:NamedThing riboflavin synthase complex An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine. got7fsn_ti cellular_component owl:Class
GO:0097572 biolink:NamedThing right nucleus One of the two nuclei found in Giardia species (trophozoite stage). It is located on the right side of the cell when viewed from the dorsal side. got7fsn_ti Due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-18T11:23:01Z cellular_component owl:Class
GO:0036389 biolink:NamedThing bacterial pre-replicative complex A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. got7fsn_ti bacterial pre-RC bf 2013-06-05T16:41:47Z cellular_component owl:Class
GO:0035475 biolink:NamedThing angioblast cell migration involved in selective angioblast sprouting The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations. got7fsn_ti bf 2010-04-23T10:04:30Z biological_process owl:Class
GO:1990906 biolink:NamedThing accessory outer segment A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors. got7fsn_ti dph 2015-11-24T13:56:06Z cellular_component owl:Class
GO:0046627 biolink:NamedThing negative regulation of insulin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling. got7fsn_ti downregulation of insulin receptor signaling pathway|negative regulation of insulin receptor signalling pathway|down-regulation of insulin receptor signaling pathway|down regulation of insulin receptor signaling pathway|inhibition of insulin receptor signaling pathway biological_process owl:Class
GO:0030049 biolink:NamedThing muscle filament sliding The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated. got7fsn_ti biological_process owl:Class
GO:0004705 biolink:NamedThing JUN kinase activity Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors. got7fsn_ti JNK|JNK3alpha1|SAPK1|c-Jun N-terminal kinase activity Reactome:R-HSA-205132|Reactome:R-HSA-9673789|Reactome:R-HSA-168136|Reactome:R-HSA-204949|Reactome:R-HSA-205075 molecular_function owl:Class
GO:0140384 biolink:NamedThing metacyclogenesis The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania. got7fsn_ti pg 2019-11-20T13:25:55Z biological_process owl:Class
NCBITaxon:5654 biolink:NamedThing got7fsn_ti owl:Class
GO:0044105 biolink:NamedThing L-xylulose reductase (NAD+) activity Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21874 jl 2009-07-09T04:25:43Z molecular_function owl:Class
GO:0048725 biolink:NamedThing cibarial fish-trap bristle development The process whose specific outcome is the progression of the cibarial fish-trap bristle over time, from its formation to the mature structure. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium. got7fsn_ti fish-trap bristle development biological_process owl:Class
GO:0070124 biolink:NamedThing mitochondrial translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. got7fsn_ti mitochondrial translation initiation biological_process owl:Class
GO:0110016 biolink:NamedThing B-WICH complex A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself. got7fsn_ti An example is BAZ1B (Q9UIG0) in human in PMID:16603771 (by IPI). kmv 2017-05-26T19:53:53Z cellular_component owl:Class
GO:1990188 biolink:NamedThing euchromatin binding Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin. got7fsn_ti tb 2013-09-11T19:18:38Z molecular_function owl:Class
GO:1990813 biolink:NamedThing meiotic centromeric cohesion protection The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation after cohesin is cleaved by separase along the arm regions. got7fsn_ti protection of centromeric cohesion during meiotic anaphase I vw 2015-07-28T16:15:31Z biological_process owl:Class
GO:0051455 biolink:NamedThing monopolar spindle attachment to meiosis I kinetochore The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs. got7fsn_ti sister kinetochore mono-orientation|attachment of spindle microtubules to kinetochore involved in meiosis I|attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|attachment of spindle microtubules to kinetochore during meiosis I|monopolar attachment Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis. biological_process owl:Class
GO:0140416 biolink:NamedThing transcription regulator inhibitor activity A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. got7fsn_ti DNA-binding transcription factor inhibitor activity https://github.com/geneontology/go-ontology/issues/18596|https://github.com/geneontology/go-ontology/issues/16132 Usage guidance: transcription regulator inhibitors bind to a transcription regulator to prevent it from reaching the chromatin. This activity does not occur at the promoter. For activities that do occur at the promoter, consider GO:0001217 ; DNA-binding transcription repressor activity or GO:0003714 ; transcription corepressor activity. An example of a transcription regulator is TCF23 Q7RTU1 is an example of a protein that regulates transcription factors by heterodimerising or binding to DbTFs and prevent DNA binding and their specific genomic binding site where the dbTF would have activated or repressed transcription. Also an example is NFKBIA P25963 which has a different way of regulating transcription factor activity by sequestering the dbTF (complex) in the cytoplasm. Another example is the HSP90 and HSP23 proteins that sequester steroid receptors away from the DNA. pg 2020-01-21T14:17:39Z molecular_function owl:Class
GO:0021837 biolink:NamedThing motogenic signaling involved in postnatal olfactory bulb interneuron migration The signaling that results in the stimulation of cell movement in the rostral migratory stream. got7fsn_ti motogenic signalling involved in postnatal olfactory bulb interneuron migration biological_process owl:Class
GO:0005621 biolink:NamedThing cellular bud scar Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age. got7fsn_ti cellular_component owl:Class
GO:0062041 biolink:NamedThing positive regulation of meiotic sister chromatid arm separation Any process that increases the rate or exent of meiotic sister chromatid arm separation, the cell cycle process in which sister chromatid arms are physically detached from each other during meiosis. got7fsn_ti dph 2018-05-04T18:20:28Z biological_process owl:Class
GO:0010449 biolink:NamedThing root meristem growth The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root. got7fsn_ti biological_process owl:Class
GO:0048766 biolink:NamedThing root hair initiation The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth. got7fsn_ti biological_process owl:Class
GO:1901039 biolink:NamedThing regulation of peptide antigen transport Any process that modulates the frequency, rate or extent of peptide antigen transport. got7fsn_ti bf 2012-06-22T04:07:56Z biological_process owl:Class
GO:0043373 biolink:NamedThing CD4-positive, alpha-beta T cell lineage commitment The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell. got7fsn_ti CD4-positive, alpha-beta T lymphocyte lineage commitment|CD4-positive, alpha-beta T-cell lineage commitment|CD4-positive, alpha-beta T-lymphocyte lineage commitment biological_process owl:Class
GO:0031641 biolink:NamedThing regulation of myelination Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons. got7fsn_ti biological_process owl:Class
GO:0008147 biolink:NamedThing structural constituent of bone The action of a molecule that contributes to the structural integrity of bone. got7fsn_ti molecular_function owl:Class
GO:0098646 biolink:NamedThing collagen sheet A protein complex that consists of collagen triple helices associated to form a sheet-like network. got7fsn_ti collagen hexagonal network cellular_component owl:Class
GO:0033263 biolink:NamedThing CORVET complex A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p. got7fsn_ti cellular_component owl:Class
GO:0009344 biolink:NamedThing nitrite reductase complex [NAD(P)H] Complex that possesses nitrite reductase [NAD(P)H] activity. got7fsn_ti See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'. cellular_component owl:Class
GO:1990406 biolink:NamedThing CGRP receptor complex A transmembrane, G protein-coupled signalling receptor complex recognized by calcitonin gene-related peptides (CGRP). got7fsn_ti calcitonin gene-related polypeptide receptor complex|CGRP-R complex|Calcitonin-gene-related peptide receptor complex An example of this is CALCRL in human (Q16602) in PMID:20826335 (inferred from direct assay). bhm 2014-07-01T14:57:43Z cellular_component owl:Class
GO:0045629 biolink:NamedThing negative regulation of T-helper 2 cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation. got7fsn_ti negative regulation of T-helper 2 cell development|down regulation of T-helper 2 cell differentiation|downregulation of T-helper 2 cell differentiation|down-regulation of T-helper 2 cell differentiation|inhibition of T-helper 2 cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:1990629 biolink:NamedThing phospholamban complex A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels. got7fsn_ti cardiac PLB complex|cardiac phospholamban complex|cardiac PLN complex An example of this is PLN in human (UniProt symbol P26678) in PMID:16043693 (inferred from direct assay). ame 2015-02-05T14:12:36Z cellular_component owl:Class
GO:1902080 biolink:NamedThing regulation of calcium ion import into sarcoplasmic reticulum Any process that modulates the frequency, rate or extent of calcium ion import into sarcoplasmic reticulum. got7fsn_ti rl 2013-04-24T16:07:50Z biological_process owl:Class
GO:0030745 biolink:NamedThing dimethylhistidine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine. got7fsn_ti histidine-alpha-N-methyltransferase activity|dimethylhistidine methyltransferase activity|S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity|S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity MetaCyc:2.1.1.44-RXN|EC:2.1.1.44|RHEA:11104|KEGG_REACTION:R04436 molecular_function owl:Class
GO:1990461 biolink:NamedThing detoxification of iron ion Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion. got7fsn_ti sart 2014-08-19T10:12:46Z biological_process owl:Class
GO:0010039 biolink:NamedThing response to iron ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus. got7fsn_ti response to iron biological_process owl:Class
GO:0035444 biolink:NamedThing nickel cation transmembrane transport The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. got7fsn_ti nickel cation membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-13T09:22:51Z biological_process owl:Class
GO:0004586 biolink:NamedThing ornithine decarboxylase activity Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine. got7fsn_ti L-ornithine carboxy-lyase activity|SpeC|L-ornithine carboxy-lyase (putrescine-forming) EC:4.1.1.17|Reactome:R-HSA-70692|MetaCyc:ORNDECARBOX-RXN|KEGG_REACTION:R00670|RHEA:22964 molecular_function owl:Class
GO:0014807 biolink:NamedThing regulation of somitogenesis Any process that modulates the frequency, rate or extent of somitogenesis. got7fsn_ti biological_process owl:Class
GO:1990159 biolink:NamedThing DnaB-DnaC-DnaT-PriA-PriC complex A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. got7fsn_ti DnaB-DnaC-DnaT-PriA-PriC preprimosome|phi-X174-type preprimosome bhm 2013-08-02T11:58:16Z cellular_component owl:Class
GO:0000801 biolink:NamedThing central element A structural unit of the synaptonemal complex found between the lateral elements. got7fsn_ti cellular_component owl:Class
GO:0060461 biolink:NamedThing right lung morphogenesis The process in which anatomical structures of the right lung are generated and organized. got7fsn_ti biological_process owl:Class
GO:0033673 biolink:NamedThing negative regulation of kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. got7fsn_ti inhibition of kinase activity|down-regulation of kinase activity|downregulation of kinase activity|down regulation of kinase activity|kinase inhibitor biological_process owl:Class
GO:0099041 biolink:NamedThing vesicle tethering to Golgi The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion. got7fsn_ti tb 2013-01-08T15:07:50Z biological_process owl:Class
GO:0038031 biolink:NamedThing non-canonical Wnt signaling pathway via JNK cascade The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade. got7fsn_ti non-canonical Wnt receptor signaling pathway via JNK cascade|non-canonical Wnt receptor signalling pathway via JNK cascade|non-canonical Wnt-activated signaling pathway via JNK cascade bf 2011-09-08T01:57:10Z biological_process owl:Class
GO:1901247 biolink:NamedThing negative regulation of lung ciliated cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation. got7fsn_ti downregulation of lung ciliated cell differentiation|inhibition of lung ciliated cell differentiation|down-regulation of lung ciliated cell differentiation|down regulation of lung ciliated cell differentiation vk 2012-08-08T08:58:58Z biological_process owl:Class
GO:1902436 biolink:NamedThing negative regulation of male mating behavior Any process that stops, prevents or reduces the frequency, rate or extent of male mating behavior. got7fsn_ti inhibition of male mating behavior|down-regulation of male mating behavior|down regulation of male mating behavior|downregulation of male mating behavior mm2 2013-10-09T15:50:05Z biological_process owl:Class
GO:0042707 biolink:NamedThing ocellus photoreceptor cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments. got7fsn_ti biological_process owl:Class
GO:0042705 biolink:NamedThing ocellus photoreceptor cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus. got7fsn_ti biological_process owl:Class
GO:0071118 biolink:NamedThing alphaV-beta3 integrin-NOV complex A protein complex that consists of an alphaV-beta3 integrin complex bound to the extracellular matrix protein NOV. got7fsn_ti ITGAV-ITGB3-FN-1-NOV complex mah 2009-11-13T02:20:20Z cellular_component owl:Class
GO:0001533 biolink:NamedThing cornified envelope A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). got7fsn_ti cellular_component owl:Class
GO:0030509 biolink:NamedThing BMP signaling pathway A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti decapentaplegic signaling pathway|BMP receptor signaling pathway|dpp signaling pathway|decapentaplegic receptor signaling pathway|BMP signalling pathway|decapentaplegic receptor signalling pathway|dpp receptor signalling pathway|dpp receptor signaling pathway|bone morphogenetic protein signaling pathway|bone morphogenetic protein signalling pathway GO:0008101 biological_process owl:Class
GO:0030299 biolink:NamedThing intestinal cholesterol absorption Uptake of cholesterol into the blood by absorption from the small intestine. got7fsn_ti biological_process owl:Class
GO:0036390 biolink:NamedThing pre-replicative complex assembly involved in bacterial-type DNA replication The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication. got7fsn_ti bacterial pre-RC assembly|bacterial pre-replicative complex assembly bf 2013-06-05T16:45:21Z biological_process owl:Class
GO:0042753 biolink:NamedThing positive regulation of circadian rhythm Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior. got7fsn_ti activation of circadian rhythm|up regulation of circadian rhythm|up-regulation of circadian rhythm|upregulation of circadian rhythm|stimulation of circadian rhythm biological_process owl:Class
GO:0045320 biolink:NamedThing chloroplast proton-transporting ATP synthase complex A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation. got7fsn_ti chloroplast hydrogen-translocating F-type ATPase complex|chloroplast proton-transporting F-type ATPase complex|hydrogen-translocating F-type ATPase complex cellular_component owl:Class
GO:0098775 biolink:NamedThing curli assembly The process of assembly of curli, extracellular fibers produced by enteric bacteria. This process occurs outside the cell, where it is coupled to secretion across the cell outer membrane via nucleation by elements of the transporter complex. got7fsn_ti biological_process owl:Class
GO:0072276 biolink:NamedThing metanephric glomerulus vasculature morphogenesis The process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus. got7fsn_ti mah 2010-04-01T02:47:32Z biological_process owl:Class
GO:0072275 biolink:NamedThing metanephric glomerulus morphogenesis The process in which the anatomical structures of the metanephric glomerulus are generated and organized. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. got7fsn_ti mah 2010-04-01T02:46:58Z biological_process owl:Class
GO:0045501 biolink:NamedThing regulation of sevenless signaling pathway Any process that modulates the frequency, rate or extent of the sevenless signaling pathway. got7fsn_ti regulation of sev signaling pathway|regulation of sevenless signalling pathway biological_process owl:Class
GO:0071557 biolink:NamedThing histone H3-K27 demethylation The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone. got7fsn_ti H3K27 demethylation mah 2010-01-15T10:59:50Z biological_process owl:Class
GO:0090611 biolink:NamedThing ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation. This process is independent of ubiquitination. got7fsn_ti tb 2014-10-23T15:27:12Z biological_process owl:Class
GO:0035183 biolink:NamedThing female germline ring canal inner rim A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins. got7fsn_ti germline ring canal inner rim|ovarian ring canal inner rim|nurse cell ring canal inner rim See also the fly_anatomy.ontology term 'inner nurse cell ring canal rim ; FBbt:00004881'. cellular_component owl:Class
GO:0004505 biolink:NamedThing phenylalanine 4-monooxygenase activity Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. got7fsn_ti L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)|phenylalanine 4-hydroxylase activity|phenylalaninase activity|phenylalanine hydroxylase activity|PAH activity https://github.com/geneontology/go-ontology/issues/20583 MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN|EC:1.14.16.1|RHEA:20273|Reactome:R-HSA-5649483|Reactome:R-HSA-71118 molecular_function owl:Class
GO:0097120 biolink:NamedThing receptor localization to synapse Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. got7fsn_ti receptor localisation to synapse pr 2011-07-31T09:20:30Z biological_process owl:Class
GO:0021829 biolink:NamedThing oligodendrocyte cell migration from the subpallium to the cortex The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development. got7fsn_ti biological_process owl:Class
CL:0000128 biolink:NamedThing got7fsn_ti owl:Class
GO:0014714 biolink:NamedThing myoblast fate commitment in head The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0021724 biolink:NamedThing inferior raphe nucleus development The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure. got7fsn_ti inferior central nucleus development|posterior raphe nucleus development biological_process owl:Class
GO:1904145 biolink:NamedThing negative regulation of meiotic cell cycle process involved in oocyte maturation Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation. got7fsn_ti down regulation of meiotic cell cycle process involved in oocyte maturation|inhibition of meiotic cell cycle process involved in oocyte maturation|downregulation of meiotic cell cycle process involved in oocyte maturation|down-regulation of meiotic cell cycle process involved in oocyte maturation tb 2015-04-14T15:59:22Z biological_process owl:Class
GO:0030089 biolink:NamedThing phycobilisome Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II. got7fsn_ti Wikipedia:Phycobilisome cellular_component owl:Class
CL:0002085 biolink:NamedThing got7fsn_ti owl:Class
GO:1902747 biolink:NamedThing negative regulation of lens fiber cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lens fiber cell differentiation. got7fsn_ti negative regulation of lens fibre cell differentiation|down-regulation of lens fiber cell differentiation|inhibition of lens fibre cell differentiation|downregulation of lens fiber cell differentiation|down regulation of lens fibre cell differentiation|downregulation of lens fibre cell differentiation|down regulation of lens fiber cell differentiation|down-regulation of lens fibre cell differentiation|inhibition of lens fiber cell differentiation mr 2014-03-03T23:19:32Z biological_process owl:Class
GO:0032284 biolink:NamedThing plastid biotin carboxylase complex A biotin carboxylase complex located in the stroma of a plastid. got7fsn_ti cellular_component owl:Class
GO:0001653 biolink:NamedThing peptide receptor activity Combining with an extracellular or intracellular peptide to initiate a change in cell activity. got7fsn_ti endogenous peptide receptor activity|exogenous peptide receptor activity molecular_function owl:Class
GO:0005784 biolink:NamedThing Sec61 translocon complex A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events. got7fsn_ti Sec61p-Sbh1p-Sss1p complex cellular_component owl:Class
GO:0061268 biolink:NamedThing mesonephric interstitial fibroblast fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric interstitial fibroblast. got7fsn_ti dph 2010-08-30T03:16:52Z biological_process owl:Class
CL:0000601 biolink:NamedThing got7fsn_ti owl:Class
GO:0048448 biolink:NamedThing stamen morphogenesis The process in which the anatomical structures of the stamen are generated and organized. got7fsn_ti GO:0048426 biological_process owl:Class
GO:0010865 biolink:NamedThing stipule development The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms. got7fsn_ti biological_process owl:Class
GO:0048340 biolink:NamedThing paraxial mesoderm morphogenesis The process in which the anatomical structures of the paraxial mesoderm are generated and organized. got7fsn_ti biological_process owl:Class
GO:0035155 biolink:NamedThing negative regulation of terminal cell fate specification, open tracheal system Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. got7fsn_ti inhibition of terminal cell fate specification|downregulation of terminal cell fate specification|down regulation of terminal cell fate specification|negative regulation of terminal cell fate specification|down-regulation of terminal cell fate specification biological_process owl:Class
GO:0033340 biolink:NamedThing pelvic fin development The process whose specific outcome is the progression of the pelvic fin over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0140092 biolink:NamedThing bBAF complex A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180. got7fsn_ti brain-specific SWI/SNF complex|brain-specific BAF complex pg 2017-09-05T09:22:41Z cellular_component owl:Class
GO:0005686 biolink:NamedThing U2 snRNP A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes. got7fsn_ti 17S U2 snRNP|snRNP U2 U2 snRNP refers to the U2 small nuclear RNA and the proteins that associate with it. U2 snRNP is not considered to be a type of spliceosomal complex by itself. cellular_component owl:Class
GO:0048090 biolink:NamedThing negative regulation of female pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in females. got7fsn_ti down regulation of female pigmentation|downregulation of female pigmentation|inhibition of female pigmentation|down-regulation of female pigmentation biological_process owl:Class
GO:0098954 biolink:NamedThing presynaptic endosome membrane The lipid bilayer surrounding a presynaptic endosome. got7fsn_ti cellular_component owl:Class
GO:0098830 biolink:NamedThing presynaptic endosome An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles. got7fsn_ti As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes. See Jahne et al., 2015 (PMID:25939282) for details. cellular_component owl:Class
GO:0060473 biolink:NamedThing cortical granule A secretory vesicle that is stored under the cell membrane of an egg. These vesicles fuse with the egg plasma membrane as part of egg activation and are part of the block to polyspermy. got7fsn_ti cortical vesicle cellular_component owl:Class
GO:1901891 biolink:NamedThing regulation of cell septum assembly Any process that modulates the frequency, rate or extent of cell septum assembly. got7fsn_ti tb 2013-02-06T20:14:40Z biological_process owl:Class
GO:1990501 biolink:NamedThing exon-exon junction subcomplex mago-y14 Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA. got7fsn_ti MGN-RBM8A complex|mago-y14 complex|exon junction subcomplex MAGOH-Y14 An example of this is Mago in drome (P49028) in PMID:12730685 (inferred from direct assay). bhm 2014-09-30T14:05:28Z cellular_component owl:Class
GO:0043066 biolink:NamedThing negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. got7fsn_ti down-regulation of apoptosis|inhibition of apoptosis|pro-survival|down regulation of apoptosis|anti-apoptosis|apoptosis inhibitor activity|downregulation of apoptosis|negative regulation of apoptosis This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is negatively regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. GO:0006916 biological_process owl:Class
GO:0075525 biolink:NamedThing viral translational termination-reinitiation A process which occurs as part of viral mRNA translation which allows expression of a downstream open reading frame (ORF) in a dicistronic mRNA. In this process, ribosomes translate the upstream ORF but following termination, a proportion of 40S subunits remain tethered to the mRNA and go on to re-initiate translation at the start codon of the downstream ORF. got7fsn_ti termination reinitiation involved in viral translation|viral translation involving termination re-initiation|viral translation involving termination-reinitiation|viral translation involving translational stop-start This term is intended to annotate gene products involved in the process of viral translational termination-reinitiation, not viral proteins produced by this translation process. jl 2011-08-04T12:01:22Z VZ:858 biological_process owl:Class
GO:0061033 biolink:NamedThing secretion by lung epithelial cell involved in lung growth The controlled release of liquid by a lung epithelial cell that contributes to an increase in size of the lung as part of its development. got7fsn_ti fetal lung liquid secretion dph 2010-02-09T10:02:55Z biological_process owl:Class
GO:0005369 biolink:NamedThing taurine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in). got7fsn_ti sodium/chloride-dependent taurine transporter molecular_function owl:Class
NCBITaxon:716545 biolink:NamedThing got7fsn_ti owl:Class
GO:1990202 biolink:NamedThing FMN reductase complex A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer. got7fsn_ti SsuE complex|flavin oxidoreductase complex, NAD(P)H-dependent|FMN reductase complex, NAD(P)H-dependent|FMN oxidoreductase complex, NAD(P)H-dependent bhm 2013-10-03T15:07:20Z cellular_component owl:Class
GO:0098578 biolink:NamedThing condensed chromatin of inactivated sex chromosome A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation. got7fsn_ti cellular_component owl:Class
GO:0016037 biolink:NamedThing light absorption The reception of a photon by a cell. got7fsn_ti absorption of light biological_process owl:Class
GO:0015011 biolink:NamedThing nickel-tetrapyrrole coenzyme metabolic process The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase. got7fsn_ti nickel-tetrapyrrole coenzyme metabolism|coenzyme F430 metabolic process biological_process owl:Class
GO:0098974 biolink:NamedThing postsynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. got7fsn_ti biological_process owl:Class
GO:0019911 biolink:NamedThing structural constituent of myelin sheath The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. got7fsn_ti molecular_function owl:Class
GO:0099579 biolink:NamedThing G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential. got7fsn_ti G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential molecular_function owl:Class
GO:0015976 biolink:NamedThing carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. got7fsn_ti heterotrophy|carbon utilization by utilization of organic compounds GO:0015978 Wikipedia:Heterotroph biological_process owl:Class
GO:0033285 biolink:NamedThing ATPase-coupled monocarboxylic acid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monocarboxylic acid(out/in) = ADP + phosphate + monocarboxylic acid(in/out). got7fsn_ti monocarboxylic acid-transporting ATPase activity|ATP-dependent monocarboxylic acid transmembrane transporter activity molecular_function owl:Class
GO:0099162 biolink:NamedThing regulation of neurotransmitter loading into synaptic vesicle Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles. got7fsn_ti regulation of synaptic vesicle neurotransmitter loading|regulation of neurotransmitter uptake into synaptic vesicle dos 2017-09-10T11:07:57Z biological_process owl:Class
GO:0061644 biolink:NamedThing protein localization to CENP-A containing chromatin Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin. got7fsn_ti dph 2014-08-29T12:17:05Z biological_process owl:Class
GO:1904349 biolink:NamedThing positive regulation of small intestine smooth muscle contraction Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction. got7fsn_ti activation of small intestine smooth muscle contraction|up regulation of small intestine smooth muscle contraction|upregulation of small intestine smooth muscle contraction|up-regulation of small intestine smooth muscle contraction sl 2015-06-11T21:37:46Z biological_process owl:Class
GO:0009923 biolink:NamedThing fatty acid elongase complex A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids. got7fsn_ti cellular_component owl:Class
GO:0009761 biolink:NamedThing CAM photosynthesis The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis. got7fsn_ti Wikipedia:Crassulacean_acid_metabolism biological_process owl:Class
GO:0021639 biolink:NamedThing trochlear nerve morphogenesis The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. got7fsn_ti CH IV morphogenesis biological_process owl:Class
GO:0016019 biolink:NamedThing peptidoglycan immune receptor activity Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response. got7fsn_ti peptidoglycan receptor activity|peptidoglycan recognition activity Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead. molecular_function owl:Class
GO:0042834 biolink:NamedThing peptidoglycan binding Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. got7fsn_ti molecular_function owl:Class
GO:0046549 biolink:NamedThing retinal cone cell development Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision. got7fsn_ti biological_process owl:Class
GO:0042670 biolink:NamedThing retinal cone cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell. got7fsn_ti biological_process owl:Class
GO:0003174 biolink:NamedThing mitral valve development The progression of the mitral valve over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-08T11:17:22Z biological_process owl:Class
GO:0070585 biolink:NamedThing protein localization to mitochondrion A process in which a protein is transported to, or maintained in, a location within the mitochondrion. got7fsn_ti protein localization in mitochondrion|protein localisation in mitochondrion mah 2009-04-24T02:31:18Z biological_process owl:Class
GO:0060942 biolink:NamedThing neural crest-derived cardiac fibroblast cell differentiation The process in which a neural crest cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T01:54:19Z biological_process owl:Class
GO:0060783 biolink:NamedThing mesenchymal smoothened signaling pathway involved in prostate gland development The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein in the mesenchymal cells of the prostate that contribute to the progression of the prostate over time. This process contributes to lung development. got7fsn_ti mesenchymal hedgehog signaling pathway involved in prostate gland development|mesenchymal hh signaling pathway involved in prostate gland development|mesenchymal smoothened signalling pathway involved in prostate gland development dph 2009-07-28T11:57:59Z biological_process owl:Class
GO:0060738 biolink:NamedThing epithelial-mesenchymal signaling involved in prostate gland development Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time. got7fsn_ti epithelial-mesenchymal signalling involved in prostate gland development dph 2009-06-15T09:31:31Z biological_process owl:Class
GO:0090256 biolink:NamedThing regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis. got7fsn_ti tb 2010-01-22T11:40:46Z biological_process owl:Class
GO:0090255 biolink:NamedThing cell proliferation involved in imaginal disc-derived wing morphogenesis The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis. got7fsn_ti tb 2010-01-22T11:40:46Z biological_process owl:Class
CHEBI:17855 biolink:NamedThing got7fsn_ti owl:Class
GO:0002533 biolink:NamedThing lysosomal enzyme secretion involved in inflammatory response The regulated release of lysosomal enzymes by a cell as part of an inflammatory response. got7fsn_ti secretion of lysosomal enzymes involved in acute inflammatory response|secretion of lysosomal enzymes involved in inflammatory response|lysosomal enzyme secretion involved in acute inflammatory response biological_process owl:Class
GO:0002393 biolink:NamedThing lysosomal enzyme production involved in inflammatory response The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels. got7fsn_ti lysosomal enzyme production involved in acute inflammatory response|production of lysosomal enzymes involved in inflammatory response|production of lysosomal enzymes involved in acute inflammatory response biological_process owl:Class
GO:0048501 biolink:NamedThing signal recognition particle, plasma membrane targeting A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to or across the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0035354 biolink:NamedThing Toll-like receptor 1-Toll-like receptor 2 protein complex A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2). got7fsn_ti TLR1:TLR2 complex|TLR1-TLR2 protein complex|TLR2:TLR1 heterodimer|toll-like receptor TLR1:TLR2 heterodimeric complex bf 2010-03-04T04:35:44Z GO:0038125 cellular_component owl:Class
GO:0008815 biolink:NamedThing citrate (pro-3S)-lyase activity Catalysis of the reaction: citrate = acetate + oxaloacetate. got7fsn_ti citrate lyase activity|citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]|citratase activity|citrate lyase|citrate aldolase activity|citrate oxaloacetate-lyase activity|citridesmolase activity|citric aldolase activity|citrase activity|citritase activity KEGG_REACTION:R00362|RHEA:10760|MetaCyc:CITLY-RXN|EC:4.1.3.6 molecular_function owl:Class
GO:2000044 biolink:NamedThing negative regulation of cardiac cell fate specification Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification. got7fsn_ti tb 2010-08-19T09:01:10Z biological_process owl:Class
GO:0110034 biolink:NamedThing negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway. got7fsn_ti negative regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway kmv 2017-07-17T20:35:55Z biological_process owl:Class
GO:0071769 biolink:NamedThing mycolate cell wall layer assembly The aggregation, arrangement and bonding together of a set of components, including arabinogalactan mycolate and trehalose dimycolate, to form the mycolate layer of the Actinobacterium-type cell wall. The mycolate layer is physically attached to the peptidoglycan layer. got7fsn_ti mycolate cell wall layer biogenesis mah 2010-03-29T04:40:45Z MetaCyc:PWY-6397 biological_process owl:Class
GO:0071212 biolink:NamedThing subsynaptic reticulum An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane. got7fsn_ti SSR mah 2009-12-01T05:05:21Z cellular_component owl:Class
GO:0072267 biolink:NamedThing metanephric capsule specification The regionalization process in which the identity of the metanephric capsule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti mah 2010-03-30T02:57:36Z biological_process owl:Class
GO:0072266 biolink:NamedThing metanephric capsule formation The developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage. got7fsn_ti mah 2010-03-30T02:56:35Z biological_process owl:Class
GO:2000057 biolink:NamedThing negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis. got7fsn_ti negative regulation of Wnt-activated signaling pathway involved in digestive tract morphogenesis|negative regulation of Wnt receptor signalling pathway involved in digestive tract morphogenesis|negative regulation of Wnt receptor signaling pathway involved in digestive tract morphogenesis jl 2010-08-20T01:17:35Z biological_process owl:Class
GO:0098683 biolink:NamedThing cochlear hair cell ribbon synapse A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density. got7fsn_ti dos 2017-02-05T16:16:49Z cellular_component owl:Class
CL:0000202 biolink:NamedThing got7fsn_ti owl:Class
GO:0070088 biolink:NamedThing PHA granule An inclusion body located in the cytoplasm that consists of polyhydroxyalkanoate (PHA) molecules and associated proteins, surrounded by a phospholipid monolayer; the proteins include PHA synthase, PHA depolymerase and 3HB-oligomer hydroxylase, phasins (PhaPs), which are thought to be the major structural proteins of the membrane surrounding the inclusion, and the regulator of phasin expression PhaR. got7fsn_ti PHB granule|polyhydroxyalkanoate granule cellular_component owl:Class
GO:0015151 biolink:NamedThing alpha-glucoside transmembrane transporter activity Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. got7fsn_ti molecular_function owl:Class
GO:0000017 biolink:NamedThing alpha-glucoside transport The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration. got7fsn_ti biological_process owl:Class
GO:0035688 biolink:NamedThing T-helper 1 cell diapedesis The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. got7fsn_ti Th1 cell diapedesis bf 2011-02-24T10:12:11Z biological_process owl:Class
GO:0140599 biolink:NamedThing mitotic nuclear bridge midzone membrane domain A nuclear membrane part at the midzone of the mitotic nuclear bridge. The midzone forms a bulge that is enriched in nuclear pores that lack baskets. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20526 pg 2021-02-10T13:39:43Z cellular_component owl:Class
GO:0006271 biolink:NamedThing DNA strand elongation involved in DNA replication The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. got7fsn_ti DNA strand elongation during DNA replication|DNA replication elongation https://github.com/geneontology/go-ontology/issues/12633 biological_process owl:Class
GO:0071729 biolink:NamedThing beak morphogenesis The process in which the anatomical structures of the beak are generated and organized. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. got7fsn_ti mah 2010-03-17T03:54:34Z biological_process owl:Class
GO:0031262 biolink:NamedThing Ndc80 complex An outer kinetochore protein complex that is part of the KMN kinetochore network (also known as the NMS complex) providing the platform with which the plus ends of spindle microtubules directly interact to form stable kinetochore-microtubule attachments. A common subunit nomenclature is used from yeast to human: Ndc80, Nuf2, Spc24, and Spc25. got7fsn_ti Nuf2-Ndc80 complex cellular_component owl:Class
GO:0038043 biolink:NamedThing interleukin-5-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti interleukin-5-mediated signalling pathway|IL-5-mediated signaling pathway bf 2011-11-03T04:18:21Z biological_process owl:Class
GO:0000426 biolink:NamedThing micropexophagy Degradation of a peroxisome by lysosomal microautophagy. got7fsn_ti Note that this term is not a child of pexophagy because the community usually uses the latter to refer to the macroautohagy process. biological_process owl:Class
GO:1905683 biolink:NamedThing peroxisome disassembly The disaggregation of a peroxisome into its constituent components. got7fsn_ti peroxisomal disassembly pr 2016-11-14T10:09:15Z biological_process owl:Class
GO:0051082 biolink:NamedThing unfolded protein binding Binding to an unfolded protein. got7fsn_ti chaperone activity https://github.com/geneontology/go-ontology/issues/21436 Reactome:R-HSA-9683772|Reactome:R-HSA-9694337 molecular_function owl:Class
GO:0016992 biolink:NamedThing lipoate synthase activity Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. got7fsn_ti lipoyl synthase activity|LS|protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity|lipoic acid synthase|protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity|LipA GO:0017140 EC:2.8.1.8|RHEA:16585|Reactome:R-HSA-6793591|MetaCyc:RXN0-949 molecular_function owl:Class
GO:0009107 biolink:NamedThing lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. got7fsn_ti lipoate biosynthesis|lipoic acid biosynthetic process|lipoic acid anabolism|lipoate formation|lipoate synthesis|lipoic acid synthesis|lipoic acid biosynthesis|lipoic acid formation|lipoate anabolism GO:0009105 biological_process owl:Class
GO:0048728 biolink:NamedThing proboscis development The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure. got7fsn_ti GO:0016349 biological_process owl:Class
GO:0042650 biolink:NamedThing prothylakoid membrane The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. got7fsn_ti cellular_component owl:Class
GO:0046818 biolink:NamedThing dense nuclear body A location in the host cell nucleus where viral proteins colocalize late in infection prior to the onset of viral DNA synthesis. More than one site can be present simultaneously. got7fsn_ti cellular_component owl:Class
GO:0007227 biolink:NamedThing signal transduction downstream of smoothened The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway. got7fsn_ti biological_process owl:Class
GO:0070143 biolink:NamedThing mitochondrial alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA in a mitochondrion, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0005334 biolink:NamedThing norepinephrine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in). got7fsn_ti noradrenaline transporter activity|norepinephrine transmembrane transporter activity|norepinephrine:sodium:chloride symporter activity|norepinephrine:sodium symporter activity|levarterenol transporter activity|sodium/norepinephrine symporter activity GO:0005333 Reactome:R-HSA-5659764|Reactome:R-HSA-443997|Wikipedia:Norepinephrine_transporter molecular_function owl:Class
GO:0051620 biolink:NamedThing norepinephrine uptake The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine. got7fsn_ti noradrenaline uptake|norepinephrine reuptake|noradrenaline reuptake|levarterenol reuptake|levarterenol uptake|norepinephrine import biological_process owl:Class
GO:0060308 biolink:NamedThing GTP cyclohydrolase I regulator activity Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. got7fsn_ti molecular_function owl:Class
GO:0044549 biolink:NamedThing GTP cyclohydrolase binding Binding to a GTP cyclohydrolase. got7fsn_ti GTP cyclohydrolase I binding jl 2012-03-22T04:38:14Z GO:0043106 molecular_function owl:Class
GO:0140516 biolink:NamedThing mitotic nuclear pore complex disassembly The mitotic cell cycle process in which the controlled breakdown of the nuclear pores occurs during open or closed mitosis. got7fsn_ti nuclear pore complex disassembly during mitosis https://github.com/geneontology/go-ontology/issues/19947 pg 2020-09-09T15:29:01Z biological_process owl:Class
NCBITaxon:5658 biolink:NamedThing got7fsn_ti owl:Class
GO:0034121 biolink:NamedThing regulation of toll-like receptor signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway. got7fsn_ti regulation of TLR signaling pathway|regulation of toll-like receptor signalling pathway biological_process owl:Class
GO:0042078 biolink:NamedThing germ-line stem cell division The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes. got7fsn_ti germ-line stem cell renewal GO:0048131 biological_process owl:Class
GO:0016483 biolink:NamedThing tryptophan hydroxylase activator activity Increases the activity of the enzyme tryptophase hydroxylase. got7fsn_ti molecular_function owl:Class
GO:0060528 biolink:NamedThing secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate. got7fsn_ti biological_process owl:Class
GO:0060525 biolink:NamedThing prostate glandular acinus development The progression of a glandular acinus of the prostate gland over time, from its initial formation to the mature structure. The glandular acini are the saclike structures of the gland. got7fsn_ti biological_process owl:Class
GO:0046528 biolink:NamedThing imaginal disc fusion The process following disc eversion whereby imaginal discs fuse with adjacent disc derivatives to form a continuous adult epidermis. got7fsn_ti biological_process owl:Class
GO:0015211 biolink:NamedThing purine nucleoside transmembrane transporter activity Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015860 biolink:NamedThing purine nucleoside transmembrane transport The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. got7fsn_ti purine nucleoside transport|purine nucleoside membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. GO:0035427 biological_process owl:Class
GO:1990395 biolink:NamedThing meiotic spindle pole body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body. got7fsn_ti tb 2014-06-06T01:41:05Z biological_process owl:Class
GO:0000212 biolink:NamedThing meiotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle. got7fsn_ti meiotic spindle organisation|meiotic spindle organization and biogenesis|meiotic spindle stabilization|spindle organization during meiosis GO:0043147 biological_process owl:Class
GO:0014041 biolink:NamedThing regulation of neuron maturation Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change. got7fsn_ti biological_process owl:Class
GO:0014716 biolink:NamedThing skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt. got7fsn_ti satellite cell asymmetric division involved in skeletal muscle regeneration Occurrence of this process outside of the context of muscle repair is probably very rare, so there is a good case for merging this with the parent class. biological_process owl:Class
GO:0004198 biolink:NamedThing calcium-dependent cysteine-type endopeptidase activity Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. got7fsn_ti calpain activity Reactome:R-HSA-8848658|Reactome:R-HSA-8863012 molecular_function owl:Class
GO:0007094 biolink:NamedThing mitotic spindle assembly checkpoint signaling A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. got7fsn_ti mitotic checkpoint|signal transduction involved in mitotic cell cycle spindle assembly checkpoint|mitotic cell cycle spindle assembly checkpoint|signaling cascade involved in SAC-independent checkpoint|signaling pathway involved in Dma1-dependent checkpoint|signalling cascade involved in SAC-independent checkpoint|Mad2-dependent checkpoint|mitotic spindle assembly checkpoint signalling|signalling pathway involved in SAC-independent checkpoint|mitotic spindle assembly checkpoint|signalling pathway involved in Dma1-dependent checkpoint|signal transduction involved in mitotic spindle assembly checkpoint|signalling cascade involved in Dma1-dependent checkpoint|signal transduction involved in SAC-independent checkpoint|signaling pathway involved in SAC-independent checkpoint|signal transduction involved in Dma1-dependent checkpoint|SAC-independent checkpoint|Dma1-dependent checkpoint|signaling cascade involved in Dma1-dependent checkpoint|mitotic spindle assembly checkpoint signaling https://github.com/geneontology/go-ontology/issues/19810|https://github.com/geneontology/go-ontology/issues/20935 GO:0072480|GO:0044810|GO:1902420 biological_process owl:Class
GO:0005461 biolink:NamedThing UDP-glucuronic acid transmembrane transporter activity Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. got7fsn_ti Reactome:R-HSA-174368|Reactome:R-HSA-5603297 molecular_function owl:Class
GO:0015787 biolink:NamedThing UDP-glucuronic acid transmembrane transport The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate. got7fsn_ti UDP-glucuronic acid transport biological_process owl:Class
GO:0019191 biolink:NamedThing cellobiose transmembrane transporter activity Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. got7fsn_ti cellobiose permease activity GO:0019190 molecular_function owl:Class
GO:0019533 biolink:NamedThing cellobiose transport The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose. got7fsn_ti biological_process owl:Class
GO:0010419 biolink:NamedThing rhamnogalacturonan II side chain metabolic process The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively. got7fsn_ti rhamnogalacturonan II side chain metabolism biological_process owl:Class
GO:0062077 biolink:NamedThing phenylacetyl-CoA 1,2-epoxidase complex A protein complex capable of catalysing the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+). got7fsn_ti paaABCE complex dph 2018-09-27T12:40:04Z cellular_component owl:Class
GO:0010124 biolink:NamedThing phenylacetate catabolic process The chemical reactions and pathways resulting in the breakdown of phenylacetate. got7fsn_ti phenylacetate degradation|phenylacetate breakdown|phenylacetate catabolism MetaCyc:PWY0-321 biological_process owl:Class
GO:0043661 biolink:NamedThing peribacteroid membrane A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells). got7fsn_ti cellular_component owl:Class
GO:1903074 biolink:NamedThing TRAIL death-inducing signaling complex assembly The aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex. got7fsn_ti TRAIL DISC formation|TRAIL DISC assembly|TRAIL death-inducing signalling complex formation|TRAIL death-inducing signalling complex assembly|TRAIL death-inducing signaling complex formation bf 2014-05-29T09:47:39Z biological_process owl:Class
GO:0036462 biolink:NamedThing TRAIL-activated apoptotic signaling pathway An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface. got7fsn_ti TRAIL-activated extrinsic apoptotic signaling pathway|tumor necrosis factor-related apoptosis-inducing ligand apoptotic signaling pathway|TRAIL-induced apoptotic signaling pathway bf 2014-06-11T09:18:41Z biological_process owl:Class
GO:0000487 biolink:NamedThing maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0005898 biolink:NamedThing interleukin-13 receptor complex A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain. got7fsn_ti IL-13 receptor complex cellular_component owl:Class
GO:0060483 biolink:NamedThing lobar bronchus mesenchyme development The biological process whose specific outcome is the progression of a lobar bronchus mesenchyme from an initial condition to its mature state. This process begins with the formation of the lobar bronchus mesenchyme and ends with the mature structure. The lobar bronchus mesenchyme is the mass of tissue composed of mesenchymal cells in the lobar bronchus. got7fsn_ti biological_process owl:Class
GO:0060482 biolink:NamedThing lobar bronchus development The biological process whose specific outcome is the progression of a lobar bronchus from an initial condition to its mature state. This process begins with the formation of the lobar bronchus and ends with the mature structure. The lobar bronchus is the major airway within the respiratory tree that starts by division of the principal bronchi on both sides and ends at the point of its own subdivision into tertiary or segmental bronchi. got7fsn_ti biological_process owl:Class
GO:0120010 biolink:NamedThing intermembrane phospholipid transfer The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. got7fsn_ti https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-16T20:56:03Z biological_process owl:Class
GO:0045063 biolink:NamedThing T-helper 1 cell differentiation The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma. got7fsn_ti T-helper 1 cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0048561 biolink:NamedThing establishment of animal organ orientation The process that determines the orientation of an animal organ or tissue with reference to an axis. got7fsn_ti biological_process owl:Class
GO:0098638 biolink:NamedThing laminin binding involved in cell-matrix adhesion Any laminin protein binding that occurs as part of cell-matrix adhesion. got7fsn_ti molecular_function owl:Class
GO:0044660 biolink:NamedThing viral release by cytolysis via pore formation in host cell membrane The killing by a virus of a cell in its host organism by cytolysis, caused by the formation by the virus of pores in its host cell membrane. got7fsn_ti cytolysis by virus via pore formation in host cell membrane|viral exit by cytolysis via pore formation in host cell membrane https://github.com/geneontology/go-ontology/issues/18852 jl 2012-08-01T13:23:41Z biological_process owl:Class
GO:0035069 biolink:NamedThing larval midgut histolysis The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly. got7fsn_ti larval midgut regression biological_process owl:Class
GO:0002042 biolink:NamedThing cell migration involved in sprouting angiogenesis The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. got7fsn_ti biological_process owl:Class
GO:0048861 biolink:NamedThing leukemia inhibitory factor signaling pathway Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti leukemia inhibitory factor signalling pathway biological_process owl:Class
GO:1901547 biolink:NamedThing negative regulation of synaptic vesicle lumen acidification Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle lumen acidification. got7fsn_ti negative regulation of proton loading|down-regulation of synaptic vesicle lumen acidification|down regulation of synaptic vesicle lumen acidification|down-regulation of synaptic vesicle lumen pH reduction|inhibition of synaptic vesicle lumen acidification|negative regulation of synaptic vesicle lumen pH reduction|downregulation of synaptic vesicle lumen pH reduction|down regulation of synaptic vesicle lumen pH reduction|inhibition of synaptic vesicle lumen pH reduction|downregulation of synaptic vesicle lumen acidification dsf 2012-10-26T16:09:28Z biological_process owl:Class
GO:0014866 biolink:NamedThing skeletal myofibril assembly The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells. got7fsn_ti biological_process owl:Class
GO:0031150 biolink:NamedThing sorocarp stalk development The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum. got7fsn_ti stalk formation|stalk development|sorophore development biological_process owl:Class
GO:0021731 biolink:NamedThing trigeminal motor nucleus development The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0002915 biolink:NamedThing negative regulation of central B cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy. got7fsn_ti downregulation of central B cell anergy|down regulation of central B cell anergy|down-regulation of central B cell anergy|inhibition of central B cell anergy biological_process owl:Class
GO:0099586 biolink:NamedThing release of sequestered calcium ion into postsynaptic cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol. got7fsn_ti biological_process owl:Class
GO:0002785 biolink:NamedThing negative regulation of antimicrobial peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production. got7fsn_ti downregulation of antimicrobial peptide production|inhibition of antimicrobial peptide production|down-regulation of antimicrobial peptide production|down regulation of antimicrobial peptide production biological_process owl:Class
GO:1904094 biolink:NamedThing positive regulation of autophagic cell death Any process that activates or increases the frequency, rate or extent of autophagic cell death. got7fsn_ti up regulation of programmed cell death by macroautophagy|activation of type II programmed cell death|positive regulation of type II programmed cell death|up-regulation of autophagic cell death|upregulation of type II programmed cell death|upregulation of programmed cell death by macroautophagy|activation of programmed cell death by macroautophagy|up regulation of autophagic cell death|positive regulation of programmed cell death by macroautophagy|upregulation of autophagic cell death|activation of autophagic cell death|up-regulation of programmed cell death by macroautophagy|up-regulation of type II programmed cell death|up regulation of type II programmed cell death bhm 2015-03-26T16:41:45Z biological_process owl:Class
GO:0048928 biolink:NamedThing posterior lateral line ganglion neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion. got7fsn_ti biological_process owl:Class
GO:2000054 biolink:NamedThing negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. got7fsn_ti negative regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|negative regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification jl 2010-08-20T01:13:35Z biological_process owl:Class
GO:1904626 biolink:NamedThing positive regulation of glycine secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission. got7fsn_ti upregulation of glycine secretion, neurotransmission|up-regulation of glycine secretion, neurotransmission|up regulation of glycine secretion, neurotransmission|activation of glycine secretion, neurotransmission hjd 2015-08-27T20:03:49Z biological_process owl:Class
GO:1901075 biolink:NamedThing negative regulation of engulfment of apoptotic cell Any process that stops, prevents or reduces the frequency, rate or extent of engulfment of apoptotic cell. got7fsn_ti down-regulation of engulfment of apoptotic cell corpse|down regulation of engulfment of apoptotic cell corpse|inhibition of engulfment of apoptotic cell corpse|downregulation of engulfment of apoptotic cell|inhibition of engulfment of cell corpse|down regulation of engulfment of apoptotic cell|negative regulation of engulfment of cell corpse|down-regulation of engulfment of apoptotic cell|downregulation of engulfment of cell corpse|down regulation of engulfment of cell corpse|negative regulation of engulfment of apoptotic cell corpse|inhibition of engulfment of apoptotic cell|downregulation of engulfment of apoptotic cell corpse|down-regulation of engulfment of cell corpse kmv 2012-07-02T07:32:43Z biological_process owl:Class
GO:0001058 biolink:NamedThing RNA polymerase V activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter krc 2010-09-23T03:45:01Z molecular_function owl:Class
GO:0001060 biolink:NamedThing transcription by RNA polymerase V The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter. got7fsn_ti transcription from RNA pol V promoter|transcription from RNA polymerase V promoter https://github.com/geneontology/go-ontology/issues/14854 krc 2010-09-23T03:54:04Z biological_process owl:Class
GO:0043313 biolink:NamedThing regulation of neutrophil degranulation Any process that modulates the frequency, rate, or extent of neutrophil degranulation. got7fsn_ti regulation of neutrophil granule exocytosis biological_process owl:Class
GO:0043282 biolink:NamedThing pharyngeal muscle development The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx. got7fsn_ti biological_process owl:Class
GO:0060465 biolink:NamedThing pharynx development The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth. got7fsn_ti pharyngeal development biological_process owl:Class
GO:1903704 biolink:NamedThing negative regulation of production of siRNA involved in RNA interference Any process that stops, prevents or reduces the frequency, rate or extent of production of siRNA involved in RNA interference. got7fsn_ti negative regulation of RNA interference, production of siRNA|down regulation of production of guide RNAs involved in RNA interference|negative regulation of production of guide RNAs involved in RNA interference|downregulation of production of guide RNAs involved in RNA interference|inhibition of production of guide RNAs involved in RNA interference|negative regulation of RNA interference, production of guide RNAs|inhibition of production of siRNA involved in RNA interference|down-regulation of RNA interference, production of siRNA|down-regulation of RNA interference, production of guide RNAs|inhibition of RNA interference, production of siRNA|downregulation of RNA interference, production of siRNA|downregulation of RNA interference, production of guide RNAs|downregulation of production of siRNA involved in RNA interference|inhibition of RNA interference, production of guide RNAs|down regulation of RNA interference, production of guide RNAs|down-regulation of production of guide RNAs involved in RNA interference|down regulation of production of siRNA involved in RNA interference|down regulation of RNA interference, production of siRNA|down-regulation of production of siRNA involved in RNA interference nc 2014-12-03T15:13:22Z biological_process owl:Class
GO:0033596 biolink:NamedThing TSC1-TSC2 complex A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. got7fsn_ti tuberin-hamartin complex|tuberous sclerosis complex cellular_component owl:Class
GO:0015614 biolink:NamedThing ABC-type D-xylose transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in). got7fsn_ti D-xylose porter activity|ATPase-coupled D-xylose transmembrane transporter activity|D-xylose-importing ATPase activity RHEA:29899|EC:7.5.2.10 molecular_function owl:Class
GO:1990962 biolink:NamedThing xenobiotic transport across blood-brain barrier The directed movement of a xenobiotic through the blood-brain barrier. got7fsn_ti drug transport across blood-brain barrier sl 2016-06-07T17:39:33Z biological_process owl:Class
GO:0140525 biolink:NamedThing antipodal site The pole of the kinetoplast associated with kinetoplast DNA replication. The antipodal sites flank the kinetoplast DNA disk and are positioned approximately 180 degrees apart. In Trypanosoma brucei and Crithidia fasciculata, minicircles are attached at antipodal sites and they contain enzymes that catalyse some of the later reactions in minicircle replication. got7fsn_ti antipodal zone https://github.com/geneontology/go-ontology/issues/20036 pg 2020-09-29T08:01:53Z cellular_component owl:Class
GO:0042320 biolink:NamedThing regulation of circadian sleep/wake cycle, REM sleep Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep. got7fsn_ti regulation of REM sleep biological_process owl:Class
GO:0097448 biolink:NamedThing spine mat A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma. got7fsn_ti pr 2012-12-17T12:34:16Z NIF_Subcellular:sao2128156969 cellular_component owl:Class
GO:0033581 biolink:NamedThing protein galactosylation in Golgi The addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus. got7fsn_ti protein amino acid galactosylation in Golgi biological_process owl:Class
GO:0016348 biolink:NamedThing imaginal disc-derived leg joint morphogenesis The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:1903237 biolink:NamedThing negative regulation of leukocyte tethering or rolling Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling. got7fsn_ti down-regulation of leukocyte tethering or rolling|inhibition of leukocyte tethering or rolling|downregulation of leukocyte tethering or rolling|down regulation of leukocyte tethering or rolling als 2014-07-31T13:07:55Z biological_process owl:Class
GO:0052619 biolink:NamedThing coenzyme F420-1:gamma-L-glutamate ligase activity Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate. got7fsn_ti MetaCyc:RXN-8081|RHEA:30523|EC:6.3.2.34 molecular_function owl:Class
CL:0000312 biolink:NamedThing got7fsn_ti owl:Class
GO:0060221 biolink:NamedThing retinal rod cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell. got7fsn_ti biological_process owl:Class
GO:0071016 biolink:NamedThing U12-type precatalytic spliceosome A spliceosomal complex that is formed by the recruitment of the preassembled U4atac/U6atac.U5 tri-snRNP to the U12-type prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U11, U12 and U4atac/U6atac.U5 snRNPs. got7fsn_ti AT-AC precatalytic spliceosome|mammalian U12-type spliceosomal complex B|mammalian U12-type spliceosomal complex B1|minor precatalytic spliceosome|yeast U12-type spliceosomal complex A2-1 mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0005692 biolink:NamedThing U11 snRNP A ribonucleoprotein complex that contains small nuclear RNA U11, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U11 snRNP, most of which remain associated with the U11 snRNA both while the U11 snRNP is free or assembled into a series of spliceosomal complexes. got7fsn_ti 12S U11 snRNP|snRNP U11 cellular_component owl:Class
GO:0004703 biolink:NamedThing G protein-coupled receptor kinase activity Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate. got7fsn_ti G protein-coupled receptor kinase activity|G-protein coupled receptor kinase activity|GRK6|GRK5|GPCRK|ATP:G-protein-coupled receptor phosphotransferase activity|STK16|GPCR kinase activity|GPCR phosphorylating protein kinase activity|G protein coupled receptor phosphorylating protein kinase activity|G-protein-coupled receptor phosphorylating protein kinase activity|GRK4 GO:0004678 RHEA:12008|EC:2.7.11.16 molecular_function owl:Class
GO:0019645 biolink:NamedThing anaerobic electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient. got7fsn_ti biological_process owl:Class
GO:0032785 biolink:NamedThing negative regulation of DNA-templated transcription, elongation Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. got7fsn_ti negative regulation of transcriptional elongation|negative regulation of transcription elongation|downregulation of RNA elongation|down-regulation of RNA elongation|down regulation of RNA elongation|inhibition of RNA elongation|negative transcription elongation regulator activity|negative regulation of DNA-dependent transcription, elongation|negative regulation of transcription elongation, DNA-dependent biological_process owl:Class
GO:0001956 biolink:NamedThing positive regulation of neurotransmitter secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter. got7fsn_ti up regulation of neurotransmitter secretion|activation of neurotransmitter secretion|upregulation of neurotransmitter secretion|stimulation of neurotransmitter secretion|up-regulation of neurotransmitter secretion biological_process owl:Class
GO:0140302 biolink:NamedThing pollen-style interaction The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte. got7fsn_ti pg 2019-02-22T13:59:33Z biological_process owl:Class
PO:0025281 biolink:NamedThing got7fsn_ti owl:Class
GO:0045178 biolink:NamedThing basal part of cell The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. got7fsn_ti cellular_component owl:Class
GO:0006294 biolink:NamedThing nucleotide-excision repair, preincision complex assembly The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage. got7fsn_ti nucleotide-excision repair, preincision complex formation biological_process owl:Class
GO:2000248 biolink:NamedThing negative regulation of establishment or maintenance of neuroblast polarity Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity. got7fsn_ti negative regulation of establishment and/or maintenance of neuroblast cell polarity vw 2010-11-11T11:40:34Z biological_process owl:Class
GO:0090307 biolink:NamedThing mitotic spindle assembly Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. got7fsn_ti spindle assembly involved in mitosis tb 2010-04-09T11:31:28Z biological_process owl:Class
GO:2000201 biolink:NamedThing negative regulation of ribosomal subunit export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus. got7fsn_ti negative regulation of ribosome export from nucleus|negative regulation of ribosomal subunit transport from nucleus to cytoplasm|negative regulation of ribosomal subunit export out of nucleus|negative regulation of ribosomal subunit-nucleus export|negative regulation of ribosomal subunit export from cell nucleus mah 2010-10-26T10:44:32Z biological_process owl:Class
GO:0036092 biolink:NamedThing phosphatidylinositol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. got7fsn_ti PI(3)P biosynthesis|phosphatidylinositol-3-phosphate formation|PtdIns3P biosynthesis|phosphatidylinositol-3-phosphate biosynthesis|phosphatidylinositol-3-phosphate synthesis|phosphatidylinositol-3-phosphate anabolism bf 2012-01-13T02:13:57Z biological_process owl:Class
GO:0060691 biolink:NamedThing epithelial cell maturation involved in salivary gland development The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the salivary gland to attain its fully functional state. got7fsn_ti dph 2009-06-08T01:06:00Z biological_process owl:Class
GO:0060690 biolink:NamedThing epithelial cell differentiation involved in salivary gland development The process in which a relatively unspecialized cell acquire specialized structural and/or functional features of an epithelial cell of the salivary gland. got7fsn_ti dph 2009-06-08T01:04:19Z biological_process owl:Class
GO:0001409 biolink:NamedThing guanine nucleotide transmembrane transporter activity Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:1903790 biolink:NamedThing guanine nucleotide transmembrane transport The process in which a guanyl nucleotide is transported across a membrane. got7fsn_ti guanyl nucleotide transmembrane transport dph 2015-01-10T13:51:54Z biological_process owl:Class
GO:0097222 biolink:NamedThing mitochondrial mRNA polyadenylation The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails. got7fsn_ti pr 2012-01-24T02:47:19Z biological_process owl:Class
GO:0150052 biolink:NamedThing regulation of postsynapse assembly Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. got7fsn_ti bc 2018-05-08T16:38:55Z biological_process owl:Class
GO:0010787 biolink:NamedThing COPI coating of Golgi vesicle, inter-Golgi cisterna The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat. got7fsn_ti biological_process owl:Class
GO:0046943 biolink:NamedThing carboxylic acid transmembrane transporter activity Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). got7fsn_ti Reactome:R-HSA-390347 molecular_function owl:Class
GO:1905039 biolink:NamedThing carboxylic acid transmembrane transport The process in which carboxylic acid is transported across a membrane. got7fsn_ti vw 2016-03-09T15:33:53Z biological_process owl:Class
GO:0120155 biolink:NamedThing MIH complex A trimeric complex involved in cytokinesis. Proposed to bridge actomyosin ring contraction and septum synthesis in yeast, resulting in the coordination of these processes, and leading to plasma membrane ingression and fusion. In the yeast Saccharomyces cerevisiae this complex consists of Mlc1p, Iqg1p and Hof1p proteins. got7fsn_ti Mlc1p-Iqg1p-Hof1p complex krc 2018-05-01T17:50:23Z cellular_component owl:Class
GO:0048934 biolink:NamedThing peripheral nervous system neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system. got7fsn_ti biological_process owl:Class
GO:0046928 biolink:NamedThing regulation of neurotransmitter secretion Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. got7fsn_ti biological_process owl:Class
GO:0003186 biolink:NamedThing tricuspid valve morphogenesis The process in which the structure of the tricuspid valve is generated and organized. got7fsn_ti dph 2009-10-08T12:05:45Z biological_process owl:Class
GO:0051974 biolink:NamedThing negative regulation of telomerase activity Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). got7fsn_ti down regulation of telomerase activity|down-regulation of telomerase activity|inhibition of telomerase activity|telomerase inhibitor|downregulation of telomerase activity biological_process owl:Class
GO:0000938 biolink:NamedThing GARP complex A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles. got7fsn_ti Golgi associated retrograde protein complex|Vps fifty three tethering complex|VFT tethering complex cellular_component owl:Class
GO:0034098 biolink:NamedThing VCP-NPL4-UFD1 AAA ATPase complex A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry). got7fsn_ti p97-Ufd1-Npl4 complex|Cdc48p-Npl4p-Ufd1p AAA ATPase complex cellular_component owl:Class
GO:1902961 biolink:NamedThing positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. got7fsn_ti up-regulation of aspartic protease activity involved in APP catabolism|up-regulation of aspartic-type endopeptidase activity involved in APP catabolic process|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|upregulation of carboxyl protease activity involved in amyloid precursor protein degradation|upregulation of aspartyl protease activity involved in APP catabolism|activation of aspartate protease activity involved in APP catabolic process|up regulation of aspartate protease activity involved in amyloid precursor protein catabolism|positive regulation of aspartic-type endopeptidase activity involved in APP catabolic process|up-regulation of aspartic protease activity involved in amyloid precursor protein degradation|up regulation of aspartate protease activity involved in APP catabolic process|positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|upregulation of aspartate protease activity involved in APP catabolic process|activation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|positive regulation of aspartic-type endopeptidase activity involved in APP catabolism|upregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|activation of aspartic protease activity involved in APP catabolism|positive regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|up regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|upregulation of aspartic protease activity involved in APP catabolism|positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|activation of aspartate protease activity involved in amyloid precursor protein degradation|upregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|upregulation of aspartic protease activity involved in amyloid precursor protein catabolism|up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|up regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|activation of aspartic-type endopeptidase activity involved in APP catabolic process|upregulation of aspartyl protease activity involved in amyloid precursor protein catabolism|positive regulation of aspartyl protease activity involved in APP catabolism|positive regulation of aspartic endopeptidase activity involved in APP catabolism|up regulation of aspartic endopeptidase activity involved in APP catabolism|positive regulation of aspartate protease activity involved in amyloid precursor protein degradation|upregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|activation of carboxyl protease activity involved in APP catabolic process|upregulation of aspartate protease activity involved in amyloid precursor protein breakdown|upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|activation of aspartic protease activity involved in amyloid precursor protein catabolism|activation of carboxyl protease activity involved in amyloid precursor protein degradation|up regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|up regulation of aspartic protease activity involved in amyloid precursor protein catabolism|positive regulation of carboxyl protease activity involved in amyloid precursor protein degradation|activation of aspartyl protease activity involved in amyloid precursor protein catabolic process|activation of aspartic protease activity involved in amyloid precursor protein breakdown|activation of aspartyl protease activity involved in amyloid precursor protein breakdown|up-regulation of aspartate protease activity involved in APP catabolic process|up regulation of aspartic protease activity involved in amyloid precursor protein breakdown|upregulation of aspartyl protease activity involved in amyloid precursor protein degradation|up regulation of aspartyl protease activity involved in amyloid precursor protein degradation|activation of aspartic protease activity involved in amyloid precursor protein catabolic process|up-regulation of aspartic endopeptidase activity involved in APP catabolism|positive regulation of aspartic protease activity involved in APP catabolism|up regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|upregulation of aspartic protease activity involved in amyloid precursor protein degradation|up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|upregulation of aspartic endopeptidase activity involved in APP catabolic process|upregulation of aspartic endopeptidase activity involved in APP catabolism|positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|up-regulation of aspartic protease activity involved in amyloid precursor protein breakdown|upregulation of aspartic protease activity involved in amyloid precursor protein catabolic process|up-regulation of aspartate protease activity involved in amyloid precursor protein degradation|upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|up-regulation of carboxyl protease activity involved in amyloid precursor protein degradation|up regulation of carboxyl protease activity involved in amyloid precursor protein degradation|activation of aspartyl protease activity involved in amyloid precursor protein catabolism|activation of aspartate protease activity involved in APP catabolism|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|activation of aspartic protease activity involved in APP catabolic process|up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|positive regulation of aspartate protease activity involved in APP catabolic process|up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|up regulation of aspartic endopeptidase activity involved in APP catabolic process|up regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|upregulation of aspartate protease activity involved in amyloid precursor protein catabolic process|up-regulation of aspartic-type endopeptidase activity involved in APP catabolism|up-regulation of aspartate protease activity involved in APP catabolism|activation of aspartate protease activity involved in amyloid precursor protein catabolism|positive regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|activation of carboxyl protease activity involved in APP catabolism|positive regulation of aspartic protease activity involved in amyloid precursor protein catabolism|activation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|activation of carboxyl protease activity involved in amyloid precursor protein breakdown|positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|upregulation of aspartic-type endopeptidase activity involved in APP catabolism|up regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|positive regulation of carboxyl protease activity involved in APP catabolism|up regulation of carboxyl protease activity involved in APP catabolic process|positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|up-regulation of aspartyl protease activity involved in APP catabolic process|up-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|positive regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|positive regulation of aspartyl protease activity involved in APP catabolic process|activation of aspartyl protease activity involved in APP catabolic process|up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|positive regulation of aspartic protease activity involved in amyloid precursor protein breakdown|up-regulation of carboxyl protease activity involved in APP catabolism|positive regulation of aspartate protease activity involved in amyloid precursor protein breakdown|activation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|positive regulation of carboxyl protease activity involved in APP catabolic process|up regulation of aspartic protease activity involved in amyloid precursor protein degradation|positive regulation of aspartate protease activity involved in amyloid precursor protein catabolism|up-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|activation of aspartate protease activity involved in amyloid precursor protein catabolic process|upregulation of aspartic protease activity involved in APP catabolic process|up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|up-regulation of aspartic protease activity involved in APP catabolic process|upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|up-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|activation of aspartic endopeptidase activity involved in APP catabolism|up-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|up regulation of aspartic-type endopeptidase activity involved in APP catabolic process|up-regulation of aspartyl protease activity involved in APP catabolism|activation of aspartic-type endopeptidase activity involved in APP catabolism|up regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|upregulation of aspartate protease activity involved in APP catabolism|activation of carboxyl protease activity involved in amyloid precursor protein catabolism|upregulation of aspartic-type endopeptidase activity involved in APP catabolic process|positive regulation of aspartic endopeptidase activity involved in APP catabolic process|upregulation of aspartyl protease activity involved in amyloid precursor protein breakdown|up regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|up regulation of aspartic protease activity involved in APP catabolism|activation of aspartic endopeptidase activity involved in APP catabolic process|positive regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|upregulation of carboxyl protease activity involved in amyloid precursor protein catabolism|activation of aspartate protease activity involved in amyloid precursor protein breakdown|upregulation of aspartyl protease activity involved in APP catabolic process|up regulation of aspartate protease activity involved in amyloid precursor protein degradation|up-regulation of aspartic endopeptidase activity involved in APP catabolic process|activation of aspartic protease activity involved in amyloid precursor protein degradation|up-regulation of aspartate protease activity involved in amyloid precursor protein breakdown|activation of carboxyl protease activity involved in amyloid precursor protein catabolic process|upregulation of carboxyl protease activity involved in amyloid precursor protein breakdown|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|upregulation of carboxyl protease activity involved in APP catabolism|positive regulation of aspartic protease activity involved in amyloid precursor protein degradation|up regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|up-regulation of carboxyl protease activity involved in APP catabolic process|up-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|activation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|upregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|activation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|up-regulation of aspartic protease activity involved in amyloid precursor protein catabolism|positive regulation of aspartate protease activity involved in APP catabolism|up regulation of aspartic protease activity involved in APP catabolic process|upregulation of aspartate protease activity involved in amyloid precursor protein degradation|up regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|positive regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of aspartyl protease activity involved in amyloid precursor protein degradation|up-regulation of aspartyl protease activity involved in amyloid precursor protein degradation|up-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|up-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|upregulation of aspartate protease activity involved in amyloid precursor protein catabolism|up-regulation of aspartate protease activity involved in amyloid precursor protein catabolism|activation of aspartyl protease activity involved in amyloid precursor protein degradation|activation of aspartyl protease activity involved in APP catabolism|positive regulation of aspartic protease activity involved in APP catabolic process|up regulation of aspartic-type endopeptidase activity involved in APP catabolism|positive regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|activation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|upregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|up regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|up regulation of aspartyl protease activity involved in APP catabolic process|up regulation of aspartate protease activity involved in APP catabolism|upregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|up-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|up regulation of carboxyl protease activity involved in APP catabolism|upregulation of carboxyl protease activity involved in APP catabolic process|up regulation of aspartate protease activity involved in amyloid precursor protein breakdown|upregulation of aspartic protease activity involved in amyloid precursor protein breakdown|up regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|up regulation of aspartyl protease activity involved in APP catabolism sjp 2014-05-06T09:07:17Z biological_process owl:Class
GO:0060042 biolink:NamedThing retina morphogenesis in camera-type eye The process in which the anatomical structure of the retina is generated and organized. got7fsn_ti retinogenesis|retina morphogenesis in camera-style eye biological_process owl:Class
GO:0015446 biolink:NamedThing ATPase-coupled arsenite transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). got7fsn_ti arsenite-transmembrane transporting ATPase activity|arsenite transporting ATPase activity|arsenite ABC transporter|arsenical resistance ATPase activity|arsenite-translocating ATPase activity|arsenical resistance efflux pump|arsenical pump-driving ATPase activity|arsenite-transporting ATPase activity EC:7.3.2.7 states that this bacterial transporter does not belong to the ABC superfamily, and instead is a member of its own family, referred to as the Ars family. Like ABC transporters, it contains two nucleotide binding sites (PMID:10970874). TC:3.A.4.1.1|MetaCyc:3.6.3.16-RXN|RHEA:11348|EC:7.3.2.7 molecular_function owl:Class
GO:0015700 biolink:NamedThing arsenite transport The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0035694 biolink:NamedThing mitochondrial protein catabolic process The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure. got7fsn_ti catabolism of mitochondrial protein|degradation of damaged mitochondrial protein bf 2011-02-28T11:06:40Z biological_process owl:Class
GO:0015772 biolink:NamedThing oligosaccharide transport The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. got7fsn_ti biological_process owl:Class
GO:0060393 biolink:NamedThing regulation of pathway-restricted SMAD protein phosphorylation Any process that modulates the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. got7fsn_ti biological_process owl:Class
GO:0071656 biolink:NamedThing negative regulation of granulocyte colony-stimulating factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor. got7fsn_ti negative regulation of pluripoietin production|negative regulation of CSF3 production|negative regulation of granulocyte colony stimulating factor production|negative regulation of filgrastim production|negative regulation of lenograstim production|negative regulation of colony stimulating factor 3 (granulocyte) production|negative regulation of G-CSF production mah 2010-02-12T10:41:14Z biological_process owl:Class
GO:0071611 biolink:NamedThing granulocyte colony-stimulating factor production The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti granulocyte colony stimulating factor production|colony stimulating factor 3 (granulocyte) production|filgrastim production|lenograstim production|CSF3 production|G-CSF production|pluripoietin production mah 2010-02-05T04:38:11Z biological_process owl:Class
GO:1905141 biolink:NamedThing negative regulation of apical ectodermal ridge formation Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation. got7fsn_ti inhibition of crista ectodermalis apicalis formation|inhibition of apical epidermal ridge formation|inhibition of AER formation|inhibition of apical ectodermal ridge formation|down regulation of apical epidermal ridge formation|down-regulation of AER formation|negative regulation of crista ectodermalis apicalis formation|down regulation of AER formation|downregulation of AER formation|negative regulation of AER formation|down regulation of crista ectodermalis apicalis formation|downregulation of crista ectodermalis apicalis formation|down regulation of apical ectodermal ridge formation|downregulation of apical epidermal ridge formation|down-regulation of crista ectodermalis apicalis formation|downregulation of apical ectodermal ridge formation|negative regulation of apical epidermal ridge formation|down-regulation of apical ectodermal ridge formation|down-regulation of apical epidermal ridge formation dph 2016-04-13T12:16:48Z biological_process owl:Class
GO:0072690 biolink:NamedThing single-celled organism vegetative growth phase A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods. got7fsn_ti stationary phase|vegetative growth of a single-celled organism https://github.com/geneontology/go-ontology/issues/18275 Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). mah 2011-08-19T12:05:19Z GO:0062178 biological_process owl:Class
NCBITaxon:Union_0000023 biolink:NamedThing got7fsn_ti owl:Class
GO:0051035 biolink:NamedThing DNA transmembrane transporter activity Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0051027 biolink:NamedThing DNA transport The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1900400 biolink:NamedThing regulation of iron ion import into cell by regulation of transcription from RNA polymerase II promoter A regulation of transcription from RNA polymerase II promoter that results in regulation of iron ion import. got7fsn_ti regulation of iron import by regulation of transcription from RNA polymerase II promoter|regulation of iron ion import by regulation of transcription from RNA polymerase II promoter|regulation of iron ion transport by regulation of transcription from RNA polymerase II promoter 2012-04-20T02:34:12Z GO:1900393 biological_process owl:Class
GO:0106005 biolink:NamedThing RNA 5'-cap (guanine-N7)-methylation The process whereby a guanine in 5-cap is methylated at the N7 position of guanine. got7fsn_ti hjd 2017-04-07T19:19:57Z biological_process owl:Class
GO:0030081 biolink:NamedThing B800-820 antenna complex Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex. got7fsn_ti light harvesting complex III|LH3 complex cellular_component owl:Class
GO:0048164 biolink:NamedThing distinct antral spaces stage The stage in oogenesis when the antral spaces become distinct and the first polar body forms. got7fsn_ti mammalian oogenesis stage 7 biological_process owl:Class
GO:0002918 biolink:NamedThing negative regulation of peripheral B cell anergy Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy. got7fsn_ti downregulation of peripheral B cell anergy|down-regulation of peripheral B cell anergy|down regulation of peripheral B cell anergy|inhibition of peripheral B cell anergy biological_process owl:Class
GO:0033210 biolink:NamedThing leptin-mediated signaling pathway A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. got7fsn_ti adipocytokine signaling pathway|leptin-mediated signalling pathway biological_process owl:Class
GO:0044320 biolink:NamedThing cellular response to leptin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. got7fsn_ti jl 2010-07-14T02:21:32Z biological_process owl:Class
GO:1990016 biolink:NamedThing neck portion of tanycyte Elongated portion of a tanycyte that sticks into the periventricular layer of neuropil where it appears to contact a blood vessel; characterized by numerous cytoplasmic extensions. A tanycyte is a specialized elongated ventricular ependymal cell that has processes that extend to the outer, or pial, surface of the CNS. got7fsn_ti neck portion pr 2012-12-19T15:17:17Z NIF_Subcellular:sao901230115 cellular_component owl:Class
GO:1902047 biolink:NamedThing polyamine transmembrane transport The process in which a polyamine macromolecule is transported across a membrane. got7fsn_ti polyamine uptake|polyamine import tb 2013-04-03T15:34:57Z GO:1905122 biological_process owl:Class
GO:2000328 biolink:NamedThing regulation of T-helper 17 cell lineage commitment Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment. got7fsn_ti regulation of Th17 fate commitment|regulation of T-helper 17 cell fate commitment|regulation of Th17 cell lineage commitment mah 2011-01-19T09:31:19Z biological_process owl:Class
GO:1903963 biolink:NamedThing arachidonate transport The directed movement of an arachidonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti arachidonic acid transport bhm 2015-02-25T16:06:14Z biological_process owl:Class
GO:1905298 biolink:NamedThing regulation of intestinal epithelial cell development Any process that modulates the frequency, rate or extent of intestinal epithelial cell development. got7fsn_ti rph 2016-06-30T11:40:47Z biological_process owl:Class
GO:1903190 biolink:NamedThing glyoxal catabolic process The chemical reactions and pathways resulting in the breakdown of glyoxal. got7fsn_ti glyoxal breakdown|glyoxal catabolism|glyoxal degradation bf 2014-07-15T10:11:51Z biological_process owl:Class
GO:0021661 biolink:NamedThing rhombomere 4 morphogenesis The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0051322 biolink:NamedThing anaphase The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Anaphase biological_process owl:Class
GO:0002632 biolink:NamedThing negative regulation of granuloma formation Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation. got7fsn_ti down-regulation of granuloma formation|downregulation of granuloma formation|down regulation of granuloma formation|inhibition of granuloma formation biological_process owl:Class
GO:0044099 biolink:NamedThing polar tube A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell. got7fsn_ti jl 2009-06-09T03:12:32Z cellular_component owl:Class
GO:0030514 biolink:NamedThing negative regulation of BMP signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway. got7fsn_ti negative regulation of bone morphogenetic protein signalling pathway|negative regulation of decapentaplegic receptor signaling pathway|down-regulation of BMP signaling pathway|negative regulation of BMP receptor signaling pathway|downregulation of BMP signaling pathway|negative regulation of decapentaplegic receptor signalling pathway|down regulation of BMP signaling pathway|negative regulation of BMP signalling pathway|negative regulation of decapentaplegic signaling pathway|negative regulation of bone morphogenetic protein signaling pathway|inhibition of BMP signaling pathway tb 2009-11-13T10:51:30Z GO:0090099 biological_process owl:Class
GO:0080126 biolink:NamedThing ovary septum development The process whose specific outcome is the progression of the ovary septum over time, from its formation to the mature structure. The ovary septum is the thin partition that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s). got7fsn_ti dhl 2009-04-28T04:34:39Z biological_process owl:Class
GO:0140510 biolink:NamedThing mitotic nuclear bridge A narrow constricted region of the nucleus that forms around the anaphase spindle during closed mitosis, and connects the main portions of the newly forming daughter nuclei. got7fsn_ti nuclear bridge pg 2020-09-07T09:59:46Z cellular_component owl:Class
GO:0097442 biolink:NamedThing CA3 pyramidal cell dendrite A dendrite of a hippocampal CA3 pyramidal cell. got7fsn_ti pr 2012-12-06T13:47:23Z NIF_Subcellular:nlx_subcell_1005001 cellular_component owl:Class
CL:1001571 biolink:NamedThing got7fsn_ti owl:Class
GO:0001124 biolink:NamedThing transcription elongation from bacterial-type RNA polymerase promoter The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase. got7fsn_ti RNA elongation from bacterial-type RNA polymerase promoter krc 2010-12-06T03:46:27Z biological_process owl:Class
GO:0032283 biolink:NamedThing plastid acetate CoA-transferase complex An acetate CoA-transferase complex located in the stroma of a plastid. got7fsn_ti cellular_component owl:Class
GO:0005740 biolink:NamedThing mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. got7fsn_ti cellular_component owl:Class
GO:0101003 biolink:NamedThing ficolin-1-rich granule membrane The lipid bilayer surrounding a ficolin-1-rich granule. got7fsn_ti mec cellular_component owl:Class
GO:1990318 biolink:NamedThing collagen type XIX trimer A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells. got7fsn_ti bhm 2014-03-14T16:05:57Z cellular_component owl:Class
GO:0003357 biolink:NamedThing noradrenergic neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline. got7fsn_ti norepinephrine secreting neuron differentiation dph 2009-12-03T10:34:30Z biological_process owl:Class
GO:0002803 biolink:NamedThing positive regulation of antibacterial peptide production Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production. got7fsn_ti stimulation of antibacterial peptide production|activation of antibacterial peptide production|up-regulation of antibacterial peptide production|up regulation of antibacterial peptide production|upregulation of antibacterial peptide production biological_process owl:Class
GO:1903467 biolink:NamedThing negative regulation of mitotic DNA replication initiation Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. got7fsn_ti down regulation of DNA replication initiation involved in mitotic DNA replication|inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication|down regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|inhibition of DNA replication initiation involved in mitotic DNA replication|downregulation of DNA replication initiation involved in mitotic cell cycle DNA replication|negative regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|down-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|downregulation of DNA replication initiation involved in mitotic DNA replication|down-regulation of DNA replication initiation involved in mitotic DNA replication vw 2014-09-23T13:38:58Z biological_process owl:Class
GO:1902969 biolink:NamedThing mitotic DNA replication Any nuclear DNA replication that is involved in a mitotic cell cycle. got7fsn_ti DNA replication involved in S-phase involved in mitotic cell cycle|DNA replication involved in S phase involved in mitotic cell cycle|mitotic cell cycle DNA replication|DNA replication during S phase involved in mitotic cell cycle|nuclear cell cycle DNA replication involved in mitotic cell cycle|mitotic nuclear cell cycle DNA replication jl 2014-05-06T15:03:03Z biological_process owl:Class
GO:0006378 biolink:NamedThing mRNA polyadenylation The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. got7fsn_ti mRNA polyadenylylation|cleavage and polyadenylylation specificity factor activity biological_process owl:Class
GO:0099173 biolink:NamedThing postsynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. got7fsn_ti postsynapse development|postsynapse organisation|postsynapse morphogenesis|postsynapse organization and biogenesis biological_process owl:Class
GO:0007526 biolink:NamedThing larval somatic muscle development The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0006270 biolink:NamedThing DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate. got7fsn_ti DNA endoreduplication initiation|DNA-dependent DNA replication initiation|DNA re-replication initiation GO:0042024 biological_process owl:Class
GO:1904866 biolink:NamedThing ventral tegmental area development The process whose specific outcome is the progression of a ventral tegmental area (VTA) over time, from its formation to the mature structure. got7fsn_ti ventral tegmental nucleus (tsai) development|ventral tegmental nucleus of tsai development|ventromedial mesencephalic tegmentum development|ventral tegmental area (Tsai) development|tegmentum ventrale development|ventral brain stem development|area tegmentalis ventralis development|ventral tegmental nucleus (Rioch) development|ventral tegmental area of tsai development|ventral tegmentum development|area tegmentalis ventralis (Tsai) development|a10a development|VTA development bf 2015-12-17T14:44:18Z biological_process owl:Class
GO:0030901 biolink:NamedThing midbrain development The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles). got7fsn_ti mesencephalon development biological_process owl:Class
GO:0061376 biolink:NamedThing mammillotegmental axonal tract development The process in which the mammillotegmental tract progresses over time, from its formation to the mature structure. The mammillotegmental tract is the collection of axons that connects the ventral diencephalon to the tegmentum and pons. got7fsn_ti dph 2010-11-09T09:09:29Z biological_process owl:Class
GO:0062091 biolink:NamedThing Ycf2/FtsHi complex A protein complex located in the chloroplast inner membrane and facing the stroma that is associated with the chloroplast inner membrane translocase complex and provides the ATPase motor activity to drive import of proteins into the chloroplast stroma. got7fsn_ti TIC complex associated chloroplast protein import motor dph 2018-11-08T20:06:11Z cellular_component owl:Class
GO:0035686 biolink:NamedThing sperm fibrous sheath A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat. got7fsn_ti flagellum fibrous sheath|flagellar fibrous sheath bf 2011-02-24T09:10:58Z cellular_component owl:Class
GO:0043979 biolink:NamedThing histone H2B-K5 acetylation The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone. got7fsn_ti histone H2B acetylation at K5 biological_process owl:Class
GO:0042644 biolink:NamedThing chloroplast nucleoid The region of a chloroplast to which the DNA is confined. got7fsn_ti cellular_component owl:Class
GO:0044688 biolink:NamedThing 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+. got7fsn_ti jl 2012-08-15T14:28:30Z molecular_function owl:Class
GO:2001116 biolink:NamedThing methanopterin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a methanopterin. got7fsn_ti methanopterin biosynthesis jl 2011-10-11T11:55:00Z biological_process owl:Class
GO:0033120 biolink:NamedThing positive regulation of RNA splicing Any process that activates or increases the frequency, rate or extent of RNA splicing. got7fsn_ti biological_process owl:Class
GO:0070062 biolink:NamedThing extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. got7fsn_ti exosome|extracellular vesicular exosome cellular_component owl:Class
GO:0071049 biolink:NamedThing nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription The process involved in retention of mRNAs that have incorrectly formed 3'-ends within the nucleus at the site of transcription. got7fsn_ti krc 2009-08-11T02:40:56Z biological_process owl:Class
GO:0071031 biolink:NamedThing nuclear mRNA surveillance of mRNA 3'-end processing The set of processes involved in identifying and degrading mRNAs with incorrectly formed 3'-ends within the nucleus. got7fsn_ti nuclear mRNA quality control of mRNAs with aberrant 3'-ends|nuclear mRNA catabolic process of mRNA with aberrant 3'-ends krc 2009-07-28T04:29:17Z biological_process owl:Class
GO:0006407 biolink:NamedThing rRNA export from nucleus The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins. got7fsn_ti rRNA-nucleus export|rRNA transport from nucleus to cytoplasm|rRNA export from cell nucleus|rRNA export out of nucleus biological_process owl:Class
GO:2000174 biolink:NamedThing regulation of pro-T cell differentiation Any process that modulates the frequency, rate or extent of pro-T cell differentiation. got7fsn_ti regulation of pro-T lymphocyte differentiation mah 2010-10-11T10:24:30Z biological_process owl:Class
GO:0099403 biolink:NamedThing maintenance of mitotic sister chromatid cohesion, telomeric The process in which the association between sister chromatids of a replicated chromosome along the length of the telomeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. got7fsn_ti maintenance of mitotic sister chromatin cohesion at telomere|maintenance of sister chromatin cohesion at telomere at mitosis|maintenance of telomeric mitotic sister chromatin cohesion biological_process owl:Class
GO:0099404 biolink:NamedThing mitotic sister chromatid cohesion, telomeric The cell cycle process in which telomeres of sister chromatids are joined during mitosis. got7fsn_ti mitotic sister chromatid cohesion at telomere|sister chromatid cohesion at telomere at mitosis|telomeric mitotic sister chromatin cohesion biological_process owl:Class
GO:0031240 biolink:NamedThing external side of cell outer membrane The side of the outer membrane that is opposite to the side that faces the periplasm of the cell. got7fsn_ti external leaflet of cell outer membrane|external side of outer membrane In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. cellular_component owl:Class
GO:0072229 biolink:NamedThing metanephric proximal convoluted tubule development The process whose specific outcome is the progression of the metanephric proximal convoluted tubule over time, from its formation to the mature structure. The metanephric proximal convoluted tubule is the most proximal portion of the metanephric proximal tubule and extends from the metanephric glomerular capsule to the metanephric proximal straight tubule. got7fsn_ti mah 2010-03-18T03:37:56Z biological_process owl:Class
GO:0015111 biolink:NamedThing iodide transmembrane transporter activity Enables the transfer of iodide ions from one side of a membrane to the other. got7fsn_ti Reactome:R-HSA-209910|Reactome:R-HSA-5627870|Reactome:R-HSA-5627802 molecular_function owl:Class
GO:0015705 biolink:NamedThing iodide transport The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0046546 biolink:NamedThing development of primary male sexual characteristics The process whose specific outcome is the progression of the primary male sexual characteristics over time, from their formation to the mature structures. The primary male sexual characteristics are the testes, and they develop in response to sex hormone secretion. got7fsn_ti biological_process owl:Class
GO:0015161 biolink:NamedThing lipid III floppase activity Enables the transbilayer of capsular-polysaccharides (Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III)) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of ECA. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi. got7fsn_ti undecaprenol-pyrophosphate O-antigen flippase activity|capsule polysaccharide transporter activity|capsular polysaccharide transmembrane transporter activity TC:2.A.66.2.3|TC:2.A.66.2.12 molecular_function owl:Class
GO:0015776 biolink:NamedThing capsular polysaccharide transport The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi. got7fsn_ti capsular-polysaccharide transport|capsule polysaccharide transport biological_process owl:Class
GO:0042281 biolink:NamedThing dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. got7fsn_ti dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase activity EC:2.4.1.267|RHEA:30635|MetaCyc:RXN-5470 molecular_function owl:Class
GO:0033281 biolink:NamedThing TAT protein transport complex A complex of three proteins integral to the cytoplasmic membrane of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) involved in membrane transport of folded proteins. got7fsn_ti TAT protein secretion complex|TAT protein translocation system complex|Twin-arginine translocation complex cellular_component owl:Class
GO:0032042 biolink:NamedThing mitochondrial DNA metabolic process The chemical reactions and pathways involving mitochondrial DNA. got7fsn_ti mtDNA metabolic process|mitochondrial DNA metabolism|mtDNA metabolism biological_process owl:Class
GO:0097237 biolink:NamedThing cellular response to toxic substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. got7fsn_ti pr 2012-02-02T12:23:31Z biological_process owl:Class
GO:0005965 biolink:NamedThing protein farnesyltransferase complex A protein complex that possesses protein farnesyltransferase activity. got7fsn_ti cellular_component owl:Class
GO:0004969 biolink:NamedThing histamine receptor activity Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. got7fsn_ti molecular_function owl:Class
GO:0051381 biolink:NamedThing histamine binding Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. got7fsn_ti molecular_function owl:Class
GO:0036021 biolink:NamedThing endolysosome lumen The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome. got7fsn_ti endolysosomal lumen bf 2011-10-13T04:32:31Z cellular_component owl:Class
GO:0043245 biolink:NamedThing extraorganismal space The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms. got7fsn_ti cellular_component owl:Class
GO:0099581 biolink:NamedThing ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. got7fsn_ti ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential|ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential molecular_function owl:Class
GO:0044233 biolink:NamedThing mitochondria-associated endoplasmic reticulum membrane A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange. got7fsn_ti ER-mitochondrion membrane contact site|Mitochondria-associated Membrane|MAM|mitochondria-associated ER membrane|endoplasmic reticulum-mitochondrion membrane contact site|mitochondria-associated membrane|mitochondria-endoplasmic reticulum (ER) contact jl 2010-01-07T04:07:24Z cellular_component owl:Class
CL:0000127 biolink:NamedThing got7fsn_ti owl:Class
GO:0080187 biolink:NamedThing floral organ senescence An organ senescence that has as a participant a floral organ. got7fsn_ti Includes senescence of petals, sepals, anthers, and any other plant organ that is part of a flower. Floral organ senescence may follow pollination. In some flowers, the organs of the corolla abscise before they senesce. dhl 2012-03-09T04:08:50Z biological_process owl:Class
GO:0035803 biolink:NamedThing egg coat formation Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. got7fsn_ti ZP assembly|vitelline envelope formation|zona pellucida assembly|VE formation bf 2011-04-19T01:48:43Z biological_process owl:Class
GO:0110095 biolink:NamedThing cellular detoxification of aldehyde Any process carried out at the cellular level that reduces or removes the toxicity of an aldehyde. These may include transport of aldehydes away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance. got7fsn_ti kmv 2018-02-16T21:19:20Z biological_process owl:Class
GO:0110096 biolink:NamedThing cellular response to aldehyde Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus. got7fsn_ti kmv 2018-02-16T21:29:18Z biological_process owl:Class
GO:0007618 biolink:NamedThing mating The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes. got7fsn_ti biological_process owl:Class
GO:0106174 biolink:NamedThing phagolysosome vesicle lumen The volume enclosed by the membrane of a phagolysosome. got7fsn_ti hjd 2019-02-11T19:10:46Z cellular_component owl:Class
GO:0046821 biolink:NamedThing extrachromosomal DNA DNA structures that are not part of a chromosome. got7fsn_ti Wikipedia:Extrachromosomal_DNA cellular_component owl:Class
GO:0007427 biolink:NamedThing epithelial cell migration, open tracheal system The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster. got7fsn_ti tracheal epithelial cell migration|tracheal cell migration biological_process owl:Class
GO:0002072 biolink:NamedThing optic cup morphogenesis involved in camera-type eye development The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus. got7fsn_ti optic cup morphogenesis involved in camera-style eye development biological_process owl:Class
GO:0090144 biolink:NamedThing mitochondrial nucleoid organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined. got7fsn_ti mitochondrial nucleoid organisation tb 2009-12-08T02:38:26Z biological_process owl:Class
GO:0061332 biolink:NamedThing Malpighian tubule bud morphogenesis The morphogenetic process in which a bud forms from the embryonic hindgut tube to form the Malpighian tubule. A bud is a protrusion that forms from the tube by localized changes in cell shape and position. got7fsn_ti Malpighian tubule formation dph 2010-09-28T01:39:32Z biological_process owl:Class
GO:1902379 biolink:NamedThing chemoattractant activity involved in axon guidance Any chemoattractant activity that is involved in axon guidance. got7fsn_ti chemoattractant activity involved in axon chemotaxis|chemoattractant activity involved in axon growth cone guidance|chemoattractant activity involved in axon pathfinding bf 2013-09-02T13:49:35Z molecular_function owl:Class
GO:0010380 biolink:NamedThing regulation of chlorophyll biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. got7fsn_ti biological_process owl:Class
GO:0007576 biolink:NamedThing nucleolar fragmentation The cell aging process that results in the nucleolus breaking down into fragments. got7fsn_ti nucleolar size increase GO:0046616 biological_process owl:Class
GO:0005674 biolink:NamedThing transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. got7fsn_ti cellular_component owl:Class
GO:0015247 biolink:NamedThing aminophospholipid flippase activity Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. got7fsn_ti aminophospholipid transporter activity|aminophospholipid transmembrane transporter activity molecular_function owl:Class
GO:0140331 biolink:NamedThing aminophospholipid translocation The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. got7fsn_ti pg 2019-05-10T13:46:34Z biological_process owl:Class
GO:1905602 biolink:NamedThing positive regulation of receptor-mediated endocytosis involved in cholesterol transport Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport. got7fsn_ti upregulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|upregulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up-regulation of receptor-mediated endocytosis involved in cholesterol transport|positive regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|upregulation of receptor-mediated endocytosis involved in cholesterol transport|up regulation of receptor-mediated endocytosis of LDL|upregulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|activation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|upregulation of receptor-mediated endocytosis of LDL|up-regulation of receptor-mediated endocytosis of LDL|positive regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up regulation of receptor-mediated endocytosis involved in cholesterol transport|positive regulation of receptor-mediated endocytosis of LDL|up-regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|activation of receptor-mediated endocytosis of LDL|up regulation of receptor-mediated endocytosis involved in intracellular cholesterol transport|activation of receptor-mediated endocytosis involved in cholesterol transport|activation of receptor-mediated endocytosis involved in intracellular cholesterol transport|up regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up-regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|activation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|up regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|up-regulation of receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|positive regulation of receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport pr 2016-10-26T13:01:59Z biological_process owl:Class
GO:0007552 biolink:NamedThing metamorphosis A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster. got7fsn_ti GO:0046699|GO:0046698 Wikipedia:Metamorphosis biological_process owl:Class
GO:0033096 biolink:NamedThing amyloplast envelope The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space. got7fsn_ti cellular_component owl:Class
GO:0004949 biolink:NamedThing cannabinoid receptor activity Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids. got7fsn_ti endocannabinoid receptor activity|cannaboid receptor molecular_function owl:Class
GO:0060715 biolink:NamedThing syncytiotrophoblast cell differentiation involved in labyrinthine layer development The process in which a chorionic trophoblast cell acquires specialized features of a syncytiotrophoblast of the labyrinthine layer of the placenta. got7fsn_ti dph 2009-06-11T08:56:18Z biological_process owl:Class
GO:0060029 biolink:NamedThing convergent extension involved in organogenesis The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ. got7fsn_ti biological_process owl:Class
GO:1902358 biolink:NamedThing sulfate transmembrane transport The directed movement of sulfate across a membrane. got7fsn_ti dph 2013-08-14T14:46:04Z biological_process owl:Class
GO:0010318 biolink:NamedThing pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity. got7fsn_ti PFK complex, beta-subunit cellular_component owl:Class
GO:1901021 biolink:NamedThing positive regulation of calcium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of calcium ion transmembrane transporter activity. got7fsn_ti activation of calcium ion transmembrane transporter activity|up regulation of calcium ion transmembrane transporter activity|up-regulation of calcium ion transmembrane transporter activity|upregulation of calcium ion transmembrane transporter activity rl 2012-06-15T07:54:40Z biological_process owl:Class
GO:0016011 biolink:NamedThing dystroglycan complex A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin. got7fsn_ti cellular_component owl:Class
GO:1990158 biolink:NamedThing DnaB-DnaC-DnaT-PriA-PriB complex A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired. got7fsn_ti DnaB-DnaC-DnaT-PriA-PriB preprimosome|phi-X174-type preprimosome bhm 2013-08-02T11:52:55Z cellular_component owl:Class
GO:0015232 biolink:NamedThing heme transmembrane transporter activity Enables the transfer of heme from one side of a membrane to the other. got7fsn_ti heme transporter activity|haem transporter activity https://github.com/geneontology/go-ontology/issues/19472 Reactome:R-HSA-9661408|Reactome:R-HSA-917892|Reactome:R-HSA-917870 molecular_function owl:Class
GO:0015886 biolink:NamedThing heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti haem transport biological_process owl:Class
GO:0030511 biolink:NamedThing positive regulation of transforming growth factor beta receptor signaling pathway Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity. got7fsn_ti up-regulation of transforming growth factor beta receptor signaling pathway|positive regulation of TGF-beta receptor signaling pathway|upregulation of transforming growth factor beta receptor signaling pathway|activation of transforming growth factor beta receptor signaling pathway|positive regulation of TGFbeta receptor signaling pathway|stimulation of transforming growth factor beta receptor signaling pathway|up regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor beta receptor signalling pathway biological_process owl:Class
GO:1901720 biolink:NamedThing negative regulation of NMS complex assembly Any process that stops, prevents or reduces the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation. got7fsn_ti inhibition of KMN network assembly involved in chromosome segregation|down regulation of KMN network assembly involved in chromosome segregation|negative regulation of KMN network assembly involved in chromosome segregation|downregulation of NMS complex association involved in chromosome segregation|downregulation of KMN network assembly involved in chromosome segregation|down-regulation of KMN network assembly involved in chromosome segregation|down-regulation of NMS complex association involved in chromosome segregation|negative regulation of NMS complex assembly involved in kinetochore assembly|down-regulation of KMN complex interaction involved in chromosome segregation|down regulation of NMS complex association involved in chromosome segregation|downregulation of NMS complex interaction involved in chromosome segregation|negative regulation of KMN complex interaction involved in chromosome segregation|down regulation of KMN complex assembly involved in chromosome segregation|down-regulation of NMS complex interaction involved in chromosome segregation|negative regulation of NMS complex association involved in chromosome segregation|inhibition of NMS complex interaction involved in chromosome segregation|inhibition of NMS complex association involved in chromosome segregation|inhibition of KMN complex interaction involved in chromosome segregation|down regulation of NMS complex interaction involved in chromosome segregation|downregulation of KMN complex interaction involved in chromosome segregation jl 2012-12-20T11:44:22Z biological_process owl:Class
GO:2000261 biolink:NamedThing negative regulation of blood coagulation, common pathway Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway. got7fsn_ti mah 2010-11-23T11:42:44Z biological_process owl:Class
GO:0030720 biolink:NamedThing oocyte localization involved in germarium-derived egg chamber formation Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber. got7fsn_ti oocyte localisation involved in germarium-derived egg chamber formation|oocyte localization during germarium-derived egg chamber formation|oogenesis, establishment and maintenance of oocyte localization|oogenesis, oocyte localization|establishment and maintenance of oocyte position during oogenesis|establishment and maintenance of oocyte localization in egg chamber|oocyte localization during oogenesis|oocyte positioning during oogenesis biological_process owl:Class
GO:0048198 biolink:NamedThing Golgi vesicle bud deformation and release The process in which cytosolic coat proteins fit together in a basketlike convex framework to form a coated deformed region on the cytoplasmic surface of the membrane. The deformed region forms into a complete vesicle and is released. got7fsn_ti dictyosome vesicle bud deformation|Golgi-derived vesicle bud deformation and release biological_process owl:Class
GO:0035015 biolink:NamedThing elongation of arista core The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions. got7fsn_ti biological_process owl:Class
GO:1990505 biolink:NamedThing mitotic DNA replication maintenance of fidelity Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication. got7fsn_ti maintenance of fidelity involved in mitotic DNA replication|mitotic DNA replication maintenance of fidelity|maintenance of fidelity involved in mitotic cell cycle DNA replication al 2014-10-01T14:09:05Z GO:1990510 biological_process owl:Class
GO:0075045 biolink:NamedThing regulation of formation by symbiont of haustorium for nutrient acquisition from host Any process that modulates the frequency, rate or extent of symbiont haustorium formation for nutrient acquisition from host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0015437 biolink:NamedThing lipopolysaccharide floppase activity Enables the transfer of a lipopolysaccharide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. got7fsn_ti lipopolysaccharide floppase activity (cytosolic to exoplasmic leaftlet)|lipopolysaccharide-transporting ATPase activity|LPS-transporting ATPase activity|ATP-dependent intramembrane lipopolysaccharide transporter activity|ATPase-coupled intramembrane lipopolysaccharide transporter activity molecular_function owl:Class
GO:0016328 biolink:NamedThing lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. got7fsn_ti cellular_component owl:Class
GO:0007495 biolink:NamedThing visceral mesoderm-endoderm interaction involved in midgut development The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut. got7fsn_ti visceral mesoderm/endoderm interaction biological_process owl:Class
GO:0060676 biolink:NamedThing ureteric bud formation The developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. This process begins when the bud protrudes from the duct and ends when it is a recognizable bud. got7fsn_ti dph 2009-06-02T01:47:23Z biological_process owl:Class
GO:0000262 biolink:NamedThing mitochondrial chromosome A chromosome found in the mitochondrion of a eukaryotic cell. got7fsn_ti mtDNA|mitochondrial DNA|mitochondrial genome NIF_Subcellular:sao1186327184 cellular_component owl:Class
GO:0042645 biolink:NamedThing mitochondrial nucleoid The region of a mitochondrion to which the DNA is confined. got7fsn_ti cellular_component owl:Class
GO:0001056 biolink:NamedThing RNA polymerase III activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter krc 2010-09-23T03:44:47Z Reactome:R-HSA-1964482 molecular_function owl:Class
GO:0072674 biolink:NamedThing multinuclear osteoclast differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. got7fsn_ti multinuclear osteoclast morphogenesis|multinuclear osteoclast formation mah 2011-02-22T02:10:38Z biological_process owl:Class
GO:0031631 biolink:NamedThing negative regulation of synaptic vesicle fusion to presynaptic active zone membrane Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. got7fsn_ti negative regulation of synaptic vesicle fusion to pre-synaptic membrane|inhibition of synaptic vesicle fusion to presynaptic membrane|downregulation of synaptic vesicle fusion to presynaptic membrane|negative regulation of synaptic vesicle fusion to presynaptic membrane|down regulation of synaptic vesicle fusion to presynaptic active zone membrane|downregulation of synaptic vesicle fusion to presynaptic active zone membrane|down regulation of synaptic vesicle fusion to presynaptic membrane|negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane|down-regulation of synaptic vesicle fusion to presynaptic membrane|down-regulation of synaptic vesicle fusion to presynaptic active zone membrane biological_process owl:Class
GO:0015083 biolink:NamedThing aluminum ion transmembrane transporter activity Enables the transfer of aluminum (Al) ions from one side of a membrane to the other. got7fsn_ti aluminium resistance permease activity|aluminum resistance permease activity|aluminium ion transporter activity GO:0015084 molecular_function owl:Class
GO:1902602 biolink:NamedThing aluminum ion transmembrane transport The process in which an aluminium ion is transported across a membrane. got7fsn_ti aluminium ion transmembrane transport|aluminium transmembrane transport|aluminum transmembrane transport pr 2013-12-20T11:09:01Z biological_process owl:Class
GO:0048368 biolink:NamedThing lateral mesoderm development The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure. got7fsn_ti lateral plate mesoderm development biological_process owl:Class
GO:0003334 biolink:NamedThing keratinocyte development The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure. got7fsn_ti dph 2009-11-24T08:55:57Z biological_process owl:Class
GO:0034117 biolink:NamedThing erythrocyte aggregation The adhesion of one erythrocyte to one or more other erythrocytes via adhesion molecules. got7fsn_ti RBC aggregation|red blood cell aggregation biological_process owl:Class
GO:0015205 biolink:NamedThing nucleobase transmembrane transporter activity Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. got7fsn_ti GO:0015392 molecular_function owl:Class
GO:0036365 biolink:NamedThing transforming growth factor beta2 activation The release of transforming growth factor beta 2 (TGF-beta2) from its latent state. got7fsn_ti TGFbeta 2 activation|TGF-beta 2 activation|TGFB2 activation bf 2012-09-24T10:15:11Z biological_process owl:Class
GO:2000520 biolink:NamedThing regulation of immunological synapse formation Any process that modulates the frequency, rate or extent of immunological synapse formation. got7fsn_ti regulation of formation of immunological synapse ebc 2011-03-23T10:18:14Z biological_process owl:Class
GO:0015541 biolink:NamedThing secondary active cyanate transmembrane transporter activity Enables the transfer of cyanate from one side of a membrane to the other. got7fsn_ti cyanate porter activity molecular_function owl:Class
GO:0015704 biolink:NamedThing cyanate transport The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0016255 biolink:NamedThing attachment of GPI anchor to protein A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain. got7fsn_ti biological_process owl:Class
UBERON:0001981 biolink:NamedThing got7fsn_ti owl:Class
GO:0000146 biolink:NamedThing microfilament motor activity A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. got7fsn_ti myosin ATPase activity|actin filament motor activity|actin-dependent ATPase activity|actin-filament motor activity|actin-activated ATPase activity|muscle motor activity https://github.com/geneontology/go-ontology/issues/20877 GO:0030898 EC:5.6.1.8|Reactome:R-HSA-432237|Reactome:R-HSA-9023171|Reactome:R-HSA-2316352 molecular_function owl:Class
GO:0016188 biolink:NamedThing synaptic vesicle maturation Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle. got7fsn_ti biological_process owl:Class
GO:0009534 biolink:NamedThing chloroplast thylakoid Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana. got7fsn_ti cellular_component owl:Class
GO:0099538 biolink:NamedThing synaptic signaling via neuropeptide Cell-cell signaling to or from a synapse, mediated by a peptide. got7fsn_ti biological_process owl:Class
GO:0000015 biolink:NamedThing phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. got7fsn_ti enolase complex cellular_component owl:Class
GO:1903581 biolink:NamedThing regulation of basophil degranulation Any process that modulates the frequency, rate or extent of basophil degranulation. got7fsn_ti sl 2014-10-31T17:37:24Z biological_process owl:Class
GO:0060340 biolink:NamedThing positive regulation of type I interferon-mediated signaling pathway Any process that increases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. got7fsn_ti positive regulation of type I interferon-mediated signalling pathway biological_process owl:Class
GO:0055015 biolink:NamedThing ventricular cardiac muscle cell development The process whose specific outcome is the progression of a ventricular cardiac muscle cell over time, from its formation to the mature state. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. got7fsn_ti ventricular cardiomyocyte development|ventricular heart muscle cell development biological_process owl:Class
GO:0099547 biolink:NamedThing regulation of translation at synapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0010228 biolink:NamedThing vegetative to reproductive phase transition of meristem The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence. got7fsn_ti floral evocation|flowering|transition from vegetative to reproductive phase biological_process owl:Class
GO:0016530 biolink:NamedThing metallochaperone activity Binding to and delivering metal ions to a target protein. got7fsn_ti molecular_function owl:Class
GO:0070236 biolink:NamedThing negative regulation of activation-induced cell death of T cells Any process that stops, prevents, or reduces the frequency, rate or extent of activation-induced cell death of T cells. got7fsn_ti inhibition of activation-induced cell death of T cells|negative regulation of activation-induced cell death of T-cells|downregulation of activation-induced cell death of T cells|negative regulation of activated T cell apoptosis|down regulation of activation-induced cell death of T cells|down-regulation of activation-induced cell death of T cells|negative regulation of antigen-driven apoptosis|negative regulation of AICD|negative regulation of activation-induced cell death of T-lymphocytes|negative regulation of activation-induced cell death of T lymphocytes biological_process owl:Class
GO:0086060 biolink:NamedThing voltage-gated sodium channel activity involved in AV node cell action potential Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated sodium channel activity involved in atrioventricular node cardiac muscle cell action potential|voltage-gated sodium channel activity involved in AV node cardiac muscle cell action potential dph 2011-11-17T12:52:48Z molecular_function owl:Class
GO:0021937 biolink:NamedThing cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation. got7fsn_ti Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation biological_process owl:Class
GO:0021940 biolink:NamedThing positive regulation of cerebellar granule cell precursor proliferation The process that activates or increases the rate or extent of granule cell precursor proliferation. got7fsn_ti up-regulation of granule cell precursor proliferation|activation of granule cell precursor proliferation|upregulation of granule cell precursor proliferation|up regulation of granule cell precursor proliferation|stimulation of granule cell precursor proliferation biological_process owl:Class
GO:0098907 biolink:NamedThing regulation of SA node cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti regulation of sinoatrial node cardiac muscle cell action potential|regulation of SA node cardiac muscle cell action potential|regulation of sinus node cardiac muscle cell action potential|regulation of SAN cardiac muscle cell action potential tb 2011-11-10T08:50:15Z biological_process owl:Class
GO:0021758 biolink:NamedThing putamen development The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain. got7fsn_ti biological_process owl:Class
GO:0003978 biolink:NamedThing UDP-glucose 4-epimerase activity Catalysis of the reaction: UDP-glucose = UDP-galactose. got7fsn_ti uridine diphospho-galactose-4-epimerase activity|uridine diphosphate glucose 4-epimerase activity|UDPgalactose 4-epimerase activity|UDP-glucose epimerase activity|uridine diphosphate galactose 4-epimerase activity|UDPglucose 4-epimerase activity|uridine diphosphoglucose 4-epimerase activity|UDP-D-galactose 4-epimerase activity|galactowaldenase activity|uridine diphosphoglucose epimerase activity|4-epimerase activity|UDPG-4-epimerase activity|UDP-galactose 4-epimerase activity RHEA:22168|EC:5.1.3.2|Reactome:R-HSA-70369|MetaCyc:UDPGLUCEPIM-RXN|Reactome:R-HSA-5610036 molecular_function owl:Class
GO:0034744 biolink:NamedThing APC-IQGAP1-Cdc42 complex A protein complex that contains the tumor suppressor protein adenomatous polyposis coli (APC), the small GTPase Cdc42, and the Rac1 and Cdc42 effector IQGAP1; may play a role in cytoskeleton organization and cell migration. got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0060770 biolink:NamedThing negative regulation of epithelial cell proliferation involved in prostate gland development Any process that decreases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. got7fsn_ti dph 2009-07-08T07:40:27Z biological_process owl:Class
GO:0021609 biolink:NamedThing accessory nerve structural organization The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. got7fsn_ti CN XI structural organization|accessory nerve structural organisation biological_process owl:Class
GO:0043998 biolink:NamedThing H2A histone acetyltransferase activity Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine. got7fsn_ti H2A histone lysine N-acetyltransferase activity molecular_function owl:Class
GO:0002004 biolink:NamedThing secretion of vasopressin involved in fast regulation of systemic arterial blood pressure The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure. got7fsn_ti secretion of vasopressin during fast regulation of systemic arterial blood pressure|secretion of vasopressin during fast control of blood pressure biological_process owl:Class
GO:1990262 biolink:NamedThing anti-Mullerian hormone signaling pathway A series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti An example of this is Amhr2 in M. musculus (Q8K592) a receptor for anti-mullerian hormone, described in PMID:23624077. hjd 2014-01-08T20:42:09Z biological_process owl:Class
GO:0001516 biolink:NamedThing prostaglandin biosynthetic process The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. got7fsn_ti prostaglandin formation|prostaglandin anabolism|prostaglandin synthesis|prostaglandin biosynthesis biological_process owl:Class
GO:0060775 biolink:NamedThing planar cell polarity pathway involved in gastrula mediolateral intercalation The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation. got7fsn_ti dph 2009-07-25T06:52:50Z biological_process owl:Class
GO:0090245 biolink:NamedThing axis elongation involved in somitogenesis The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis. got7fsn_ti tb 2010-01-22T10:54:29Z biological_process owl:Class
GO:0019172 biolink:NamedThing glyoxalase III activity Catalysis of the reaction: methylglyoxal + H2O = D-lactate. got7fsn_ti (R)-lactate hydro-lyase|glutathione-independent glyoxalase activity|D-lactate dehydratase Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC:4.4.1.5 (lactoylglutathione lyase) and EC:3.1.2.6 (hydroxyacylglutathione hydrolase). MetaCyc:GLYOXIII-RXN|RHEA:27754|EC:4.2.1.130 molecular_function owl:Class
GO:0072269 biolink:NamedThing metanephric long descending thin limb development The process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla. got7fsn_ti mah 2010-03-30T03:12:05Z biological_process owl:Class
GO:0031260 biolink:NamedThing pseudopodium membrane The portion of the plasma membrane surrounding a pseudopodium. got7fsn_ti cellular_component owl:Class
GO:0031283 biolink:NamedThing negative regulation of guanylate cyclase activity Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity. got7fsn_ti downregulation of guanylate cyclase activity|down-regulation of guanylate cyclase activity|inhibition of guanylate cyclase activity|down regulation of guanylate cyclase activity biological_process owl:Class
GO:0010443 biolink:NamedThing meristemoid mother cell division The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC. got7fsn_ti meristemoid division biological_process owl:Class
GO:0009942 biolink:NamedThing longitudinal axis specification The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root. got7fsn_ti longitudinal axis determination|apical-basal pattern specification biological_process owl:Class
GO:0034107 biolink:NamedThing negative regulation of erythrocyte clearance Any process that stops, prevents, or reduces the frequency, rate, or extent of erythrocyte clearance. got7fsn_ti negative regulation of neocytolysis|negative regulation of red blood cell clearance|negative regulation of RBC clearance biological_process owl:Class
GO:0031617 biolink:NamedThing NMS complex A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes. got7fsn_ti KMN kinetochore network|Ndc80-MIND-Spc7 complex|KNL-1-Mis12-Ndc80 cellular_component owl:Class
GO:0005628 biolink:NamedThing prospore membrane The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe. got7fsn_ti ascospore-type prospore membrane|forespore membrane|FSM cellular_component owl:Class
GO:0062238 biolink:NamedThing Smp focus A DNA-binding ribonucleoprotein complex that contains a lncRNA complementary to the bound chromosomal locus and is involved in the tethering homologous chromosomes together during chromosome pairing at meiotic prophase I. got7fsn_ti Smp dot dph 2020-04-20T14:23:04Z cellular_component owl:Class
GO:0042581 biolink:NamedThing specific granule Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase. got7fsn_ti secondary granule Wikipedia:Specific_granule cellular_component owl:Class
GO:0102973 biolink:NamedThing norsolorinate anthrone synthase activity Catalysis of the reaction: 7 malonyl-CoA + 5 H+ + a hexanoyl-[acyl-carrier-protein] = norsolorinate anthrone + 7 coenzyme A + 7 carbon dioxide + 2 H2O + a holo-[acyl-carrier protein]. got7fsn_ti norsolorinic acid synthase MetaCyc:RXN-9479|EC:2.3.1.221|RHEA:35179 molecular_function owl:Class
GO:0045698 biolink:NamedThing negative regulation of synergid differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of synergid cell differentiation. got7fsn_ti downregulation of synergid differentiation|down regulation of synergid differentiation|negative regulation of synergid cell differentiation|down-regulation of synergid differentiation|inhibition of synergid differentiation biological_process owl:Class
GO:0043281 biolink:NamedThing regulation of cysteine-type endopeptidase activity involved in apoptotic process Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis. got7fsn_ti regulation of caspase activity|regulation of caspase activation GO:0043026 biological_process owl:Class
GO:1900740 biolink:NamedThing positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway. got7fsn_ti up regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|up-regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|upregulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|up regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|upregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|activation of protein insertion into mitochondrial membrane involved in induction of apoptosis|up-regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|activation of protein insertion into mitochondrion membrane during induction of apoptosis|upregulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|upregulation of protein insertion into mitochondrion membrane during induction of apoptosis|up regulation of protein insertion into mitochondrial membrane during induction of apoptosis|up regulation of protein insertion into mitochondrion membrane during induction of apoptosis|positive regulation of protein insertion into mitochondrial membrane involved in induction of apoptosis|up regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|positive regulation of protein insertion into mitochondrion membrane during induction of apoptosis|up-regulation of protein insertion into mitochondrion membrane during induction of apoptosis|up-regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|activation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|positive regulation of protein insertion into mitochondrial membrane during induction of apoptosis|activation of protein insertion into mitochondrial membrane during induction of apoptosis|positive regulation of insertion of proteins into mitochondrial membranes during the induction of apoptosis|upregulation of protein insertion into mitochondrial membrane during induction of apoptosis|up-regulation of protein insertion into mitochondrial membrane during induction of apoptosis|activation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway pr 2012-05-28T02:28:40Z biological_process owl:Class
GO:0070986 biolink:NamedThing left/right axis specification The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes). got7fsn_ti left-right axis specification|left/right axis determination mah 2009-10-29T01:43:34Z biological_process owl:Class
GO:0035216 biolink:NamedThing haltere disc development Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum. got7fsn_ti biological_process owl:Class
GO:0001945 biolink:NamedThing lymph vessel development The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:1904443 biolink:NamedThing positive regulation of thyroid gland epithelial cell proliferation Any process that activates or increases the frequency, rate or extent of thyroid gland epithelial cell proliferation. got7fsn_ti up regulation of thyroid gland epithelial cell proliferation|positive regulation of Hurthle cell proliferation|upregulation of thyroid follicular cell proliferation|activation of thyroid follicular cell proliferation|activation of Hurthle cell proliferation|up-regulation of thyroid follicular cell proliferation|up-regulation of Hurthle cell proliferation|activation of thyroid gland epithelial cell proliferation|up-regulation of thyroid gland epithelial cell proliferation|up regulation of thyroid follicular cell proliferation|upregulation of thyroid gland epithelial cell proliferation|up regulation of Hurthle cell proliferation|upregulation of Hurthle cell proliferation|positive regulation of thyroid follicular cell proliferation sl 2015-07-06T15:41:21Z biological_process owl:Class
GO:0098846 biolink:NamedThing podocyte foot A cell projection of a podocyte (glomerular visceral epithelial cell) forming a foot-like structure projecting from a podocyte primary projection, that wraps around capillaries of a renal glomerulus. Adjacent feet (pedicels) interdigitate, leaving thin filtration slits between them, which are covered by slit diaphragms. got7fsn_ti podocyte foot process|pedicel|secondary podocyte projection Wikipedia:Podocyte cellular_component owl:Class
CL:0000653 biolink:NamedThing got7fsn_ti owl:Class
GO:0042961 biolink:NamedThing ATPase-coupled antimonite transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out). got7fsn_ti ATP-dependent antimonite transporter activity|antimonite-transporting ATPase activity molecular_function owl:Class
GO:0015699 biolink:NamedThing antimonite transport The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0010096 biolink:NamedThing specification of sepal identity The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0048453 biolink:NamedThing sepal formation The process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048423 biological_process owl:Class
GO:0015110 biolink:NamedThing cyanate transmembrane transporter activity Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0034591 biolink:NamedThing rhoptry lumen The volume enclosed by the rhoptry membrane. got7fsn_ti cellular_component owl:Class
GO:0009736 biolink:NamedThing cytokinin-activated signaling pathway A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti cytokinin mediated signalling|cytokinin signaling|cytokinin mediated signaling pathway biological_process owl:Class
GO:0071368 biolink:NamedThing cellular response to cytokinin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus. got7fsn_ti mah 2009-12-11T03:13:47Z biological_process owl:Class
GO:0002645 biolink:NamedThing positive regulation of tolerance induction Any process that activates or increases the frequency, rate, or extent of tolerance induction. got7fsn_ti up-regulation of tolerance induction|up regulation of tolerance induction|upregulation of tolerance induction|activation of tolerance induction|stimulation of tolerance induction biological_process owl:Class
GO:0071030 biolink:NamedThing nuclear mRNA surveillance of spliceosomal pre-mRNA splicing The set of processes involved in identifying and degrading incorrectly spliced pre-mRNAs within the nucleus. got7fsn_ti nuclear mRNA quality control of incorrectly spliced pre-mRNA|nuclear RNA catabolic process of incorrectly spliced pre-mRNA krc 2009-07-28T04:24:04Z biological_process owl:Class
GO:1903690 biolink:NamedThing negative regulation of wound healing, spreading of epidermal cells Any process that stops, prevents or reduces the frequency, rate or extent of wound healing, spreading of epidermal cells. got7fsn_ti downregulation of wound healing, spreading of epidermal cells|inhibition of wound healing, spreading of epidermal cells|down regulation of wound healing, spreading of epidermal cells|down-regulation of wound healing, spreading of epidermal cells als 2014-12-01T15:54:27Z biological_process owl:Class
GO:1990233 biolink:NamedThing intramolecular phosphotransferase complex A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule. got7fsn_ti bhm 2013-11-12T13:10:12Z cellular_component owl:Class
GO:0060011 biolink:NamedThing Sertoli cell proliferation The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. got7fsn_ti biological_process owl:Class
GO:0016342 biolink:NamedThing catenin complex Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton. got7fsn_ti cellular_component owl:Class
GO:2000555 biolink:NamedThing negative regulation of T-helper 1 cell cytokine production Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production. got7fsn_ti negative regulation of Th1 cell cytokine production ebc 2011-04-03T07:35:51Z biological_process owl:Class
GO:0038140 biolink:NamedThing ERBB4-ERBB3 complex A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission. got7fsn_ti ERBB4:ERBB3 heterodimer|ERBB3-ERBB4 complex bf 2012-03-30T02:04:16Z cellular_component owl:Class
GO:0071315 biolink:NamedThing cellular response to morphine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure. got7fsn_ti mah 2009-12-10T04:53:46Z biological_process owl:Class
GO:0010009 biolink:NamedThing cytoplasmic side of endosome membrane The side (leaflet) of the endosome membrane that faces the cytoplasm. got7fsn_ti external side of endosome membrane|external leaflet of endosome membrane cellular_component owl:Class
GO:0060526 biolink:NamedThing prostate glandular acinus morphogenesis The process in which the prostate glandular acini are generated and organized. The glandular acini are the saclike structures of the gland. got7fsn_ti biological_process owl:Class
GO:0051032 biolink:NamedThing nucleic acid transmembrane transporter activity Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information. got7fsn_ti molecular_function owl:Class
GO:0050657 biolink:NamedThing nucleic acid transport The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1901309 biolink:NamedThing negative regulation of sterol regulatory element binding protein cleavage Any process that stops, prevents or reduces the frequency, rate or extent of sterol regulatory element binding protein cleavage. got7fsn_ti down regulation of sterol regulatory element binding protein cleavage|inhibition of SREBP processing|inhibition of sterol regulatory element binding protein cleavage|inhibition of SREBP cleavage|negative regulation of SREBP cleavage|downregulation of sterol regulatory element binding protein cleavage|downregulation of SREBP cleavage|down-regulation of sterol regulatory element binding protein cleavage|down regulation of SREBP cleavage|down-regulation of SREBP cleavage bf 2012-08-21T16:43:32Z biological_process owl:Class
GO:0001835 biolink:NamedThing blastocyst hatching The hatching of the cellular blastocyst from the zona pellucida. got7fsn_ti See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'. biological_process owl:Class
GO:0001824 biolink:NamedThing blastocyst development The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. got7fsn_ti See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. biological_process owl:Class
GO:0099038 biolink:NamedThing ceramide floppase activity Catalysis of the movement of ceramide from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. got7fsn_ti ATP-dependent ceramide transporter activity|ceramide-translocating ATPase activity|ATPase-coupled ceramide transporter activity|ceramide floppase activity (cytosolic to exoplasmic leaftlet) molecular_function owl:Class
GO:0099040 biolink:NamedThing ceramide translocation The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet. got7fsn_ti biological_process owl:Class
GO:0035808 biolink:NamedThing meiotic recombination initiation complex A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins. got7fsn_ti bf 2011-04-20T11:52:50Z cellular_component owl:Class
GO:1905701 biolink:NamedThing positive regulation of xenobiotic detoxification by transmembrane export across the plasma membrane Any process that activates or increases the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti upregulation of drug transmembrane export|positive regulation of xenobiotic transmembrane export|up-regulation of drug transmembrane export|up regulation of drug transmembrane export|positive regulation of drug transmembrane export|activation of drug transmembrane export https://github.com/geneontology/go-ontology/issues/19460|https://github.com/geneontology/go-ontology/issues/17083 sl 2016-11-15T16:46:44Z biological_process owl:Class
GO:0015100 biolink:NamedThing vanadium ion transmembrane transporter activity Enables the transfer of vanadium (V) ions from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015676 biolink:NamedThing vanadium ion transport The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0009542 biolink:NamedThing granum Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis. got7fsn_ti cellular_component owl:Class
GO:1901219 biolink:NamedThing regulation of cardiac chamber morphogenesis Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis. got7fsn_ti regulation of heart chamber morphogenesis rl 2012-08-06T17:59:11Z biological_process owl:Class
GO:0008509 biolink:NamedThing anion transmembrane transporter activity Enables the transfer of a negatively charged ion from one side of a membrane to the other. got7fsn_ti anion transporter activity Reactome:R-HSA-166214 molecular_function owl:Class
GO:0006127 biolink:NamedThing glycerophosphate shuttle The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle. got7fsn_ti MetaCyc:PWY-6118 biological_process owl:Class
GO:0005463 biolink:NamedThing UDP-N-acetylgalactosamine transmembrane transporter activity Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. got7fsn_ti molecular_function owl:Class
GO:0015789 biolink:NamedThing UDP-N-acetylgalactosamine transmembrane transport The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. got7fsn_ti UDP-N-acetylgalactosamine transport biological_process owl:Class
GO:1901396 biolink:NamedThing negative regulation of transforming growth factor beta2 activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta2 activation. got7fsn_ti inhibition of TGFB2 activation|downregulation of TGFB2 activation|inhibition of TGF-beta 2 activation|downregulation of transforming growth factor beta2 activation|down-regulation of TGFB2 activation|down regulation of TGFbeta 2 activation|inhibition of transforming growth factor beta2 activation|down-regulation of TGF-beta 2 activation|inhibition of TGFbeta 2 activation|down-regulation of transforming growth factor beta2 activation|negative regulation of TGFbeta 2 activation|negative regulation of TGFB2 activation|negative regulation of TGF-beta 2 activation|down regulation of TGF-beta 2 activation|down-regulation of TGFbeta 2 activation|downregulation of TGF-beta 2 activation|downregulation of TGFbeta 2 activation|down regulation of TGFB2 activation|down regulation of transforming growth factor beta2 activation bf 2012-10-01T10:47:59Z biological_process owl:Class
GO:0070268 biolink:NamedThing cornification A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability). got7fsn_ti biological_process owl:Class
GO:0000794 biolink:NamedThing condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. got7fsn_ti meiotic chromosome|nuclear mitotic chromosome Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. cellular_component owl:Class
GO:0006272 biolink:NamedThing leading strand elongation The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork. got7fsn_ti https://github.com/geneontology/go-ontology/issues/12633 biological_process owl:Class
GO:1902942 biolink:NamedThing negative regulation of voltage-gated chloride channel activity Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated chloride channel activity. got7fsn_ti downregulation of voltage-dependent chloride channel activity|down-regulation of voltage-gated chloride channel activity|downregulation of voltage gated chloride channel activity|inhibition of voltage gated chloride channel activity|negative regulation of voltage gated chloride channel activity|down regulation of voltage-gated chloride channel activity|inhibition of voltage-dependent chloride channel activity|downregulation of voltage-gated chloride channel activity|down regulation of voltage-dependent chloride channel activity|negative regulation of voltage-dependent chloride channel activity|inhibition of voltage-gated chloride channel activity|down-regulation of voltage gated chloride channel activity|down regulation of voltage gated chloride channel activity|down-regulation of voltage-dependent chloride channel activity als 2014-04-28T08:55:37Z biological_process owl:Class
GO:0008200 biolink:NamedThing ion channel inhibitor activity Binds to and stops, prevents, or reduces the activity of an ion channel. got7fsn_ti molecular_function owl:Class
GO:0015441 biolink:NamedThing ABC-type beta-glucan transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out). got7fsn_ti beta-glucan-transporting ATPase activity|ATP-dependent beta-glucan transporter activity|ABC-type beta-glucan transporter|ATPase-coupled beta-glucan transporter activity|beta-glucan ABC transporter EC:7.5.2.3|RHEA:18453|MetaCyc:3.6.3.42-RXN molecular_function owl:Class
GO:0015775 biolink:NamedThing beta-glucan transport The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. got7fsn_ti biological_process owl:Class
GO:0034451 biolink:NamedThing centriolar satellite A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome. got7fsn_ti cellular_component owl:Class
GO:0022897 biolink:NamedThing proton-dependent peptide secondary active transmembrane transporter activity Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. got7fsn_ti hydrogen/oligopeptide symporter molecular_function owl:Class
GO:0038132 biolink:NamedThing neuregulin binding Binding to a neuregulin, a member of the EGF family of growth factors. got7fsn_ti bf 2012-03-30T10:59:56Z molecular_function owl:Class
GO:1990008 biolink:NamedThing neurosecretory vesicle A large cytoplasmic membrane-bounded vesicle with an electron dense granular core, up to 150-200 nm in diameter, found in neurosecretory cells in the hypothalamus. got7fsn_ti pr 2012-12-12T09:56:14Z NIF_Subcellular:sao2031592629 cellular_component owl:Class
CL:0000165 biolink:NamedThing got7fsn_ti owl:Class
GO:0008385 biolink:NamedThing IkappaB kinase complex A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. got7fsn_ti IKK complex|heterotrimeric IKK complex|trimeric IKK complex cellular_component owl:Class
GO:0046798 biolink:NamedThing viral portal complex A multimeric ring of proteins through which the DNA enters and exits the viral capsid. got7fsn_ti cellular_component owl:Class
GO:0070154 biolink:NamedThing mitochondrial lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA in a mitochondrion, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:1904888 biolink:NamedThing cranial skeletal system development The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus. got7fsn_ti craniofacial development|osteocranium development|cranial skeleton development|cranium development bf 2016-01-07T13:45:06Z biological_process owl:Class
CHEBI:15361 biolink:NamedThing got7fsn_ti owl:Class
GO:0060939 biolink:NamedThing epicardium-derived cardiac fibroblast cell development The process whose specific outcome is the progression of an epicardial-derived cardiac fibroblast over time, from its formation to the mature state. A epicardial-derived cardiac fibroblast is a connective tissue cell of the heart that arises from the epicardium and secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T01:29:19Z biological_process owl:Class
GO:1901019 biolink:NamedThing regulation of calcium ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of calcium ion transmembrane transporter activity. got7fsn_ti rl 2012-06-15T07:54:12Z biological_process owl:Class
GO:0099185 biolink:NamedThing postsynaptic intermediate filament cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton. got7fsn_ti dos 2017-12-20T13:47:30Z biological_process owl:Class
GO:1990295 biolink:NamedThing post-anaphase microtubule array A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center. got7fsn_ti PAA|post-anaphase array The best-characterized example is found in the fission yeast Schizosaccharomyces pombe. The eMTOC is cortical, but the post-anaphase array microtubules are not exclusively cortical. mah 2014-02-20T13:54:23Z cellular_component owl:Class
GO:0009508 biolink:NamedThing plastid chromosome A circular DNA molecule containing plastid encoded genes. got7fsn_ti cellular_component owl:Class
GO:0042646 biolink:NamedThing plastid nucleoid The region of a plastid to which the DNA is confined. got7fsn_ti cellular_component owl:Class
GO:0015128 biolink:NamedThing gluconate transmembrane transporter activity Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. got7fsn_ti L-idonate/D-gluconate:hydrogen symporter activity molecular_function owl:Class
GO:0035429 biolink:NamedThing gluconate transmembrane transport The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. got7fsn_ti gluconate transport|gluconate membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-08T10:33:46Z GO:0015725 biological_process owl:Class
GO:0061155 biolink:NamedThing pulmonary artery endothelial tube morphogenesis The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery. got7fsn_ti dph 2010-06-15T09:09:04Z biological_process owl:Class
GO:1902909 biolink:NamedThing negative regulation of melanosome transport Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport. got7fsn_ti down regulation of melanosome transport|inhibition of melanosome transport|down-regulation of melanosome transport|downregulation of melanosome transport als 2014-04-17T11:40:28Z biological_process owl:Class
GO:0006913 biolink:NamedThing nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. got7fsn_ti nucleocytoplasmic shuttling Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. GO:0000063 biological_process owl:Class
GO:1990378 biolink:NamedThing upstream stimulatory factor complex A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters. got7fsn_ti USF1 homodimer|USF1-USF2 heterodimer|USF2 homodimer|USF complex An example of this is USF1 in human (UniProt symbol P22415) in PMID:8576131 (inferred from direct assay). bhm 2014-05-07T15:41:42Z cellular_component owl:Class
GO:0031927 biolink:NamedThing pyridoxamine transmembrane transporter activity Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. got7fsn_ti molecular_function owl:Class
GO:1903091 biolink:NamedThing pyridoxamine transmembrane transport The process in which pyridoxamine is transported across a membrane. got7fsn_ti al 2014-06-03T10:41:20Z biological_process owl:Class
GO:0043671 biolink:NamedThing endexine The inner part of the exine, which stains. got7fsn_ti Note that endexine is distinguished on staining properties; compare with 'sexine ; GO:0043673'. See also 'ectexine ; GO:0043669'. cellular_component owl:Class
GO:0016559 biolink:NamedThing peroxisome fission The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. got7fsn_ti peroxisome proliferation|peroxisome division biological_process owl:Class
GO:0022027 biolink:NamedThing interkinetic nuclear migration The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle. got7fsn_ti biological_process owl:Class
GO:1903682 biolink:NamedThing negative regulation of epithelial cell-cell adhesion involved in epithelium migration Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. got7fsn_ti inhibition of epithelial cell-cell adhesion involved in epithelium migration|downregulation of epithelial cell-cell adhesion involved in epithelium migration|down regulation of epithelial cell-cell adhesion involved in epithelium migration|down-regulation of epithelial cell-cell adhesion involved in epithelium migration als 2014-12-01T13:25:14Z biological_process owl:Class
GO:0008515 biolink:NamedThing sucrose transmembrane transporter activity Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. got7fsn_ti sucrose permease (PTS) activity|sucrose permease activity GO:0019188 molecular_function owl:Class
GO:0015774 biolink:NamedThing polysaccharide transport The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. got7fsn_ti biological_process owl:Class
GO:0042945 biolink:NamedThing D-serine transmembrane transporter activity Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid. got7fsn_ti D-serine transporter activity|D-serine permease activity molecular_function owl:Class
GO:0042942 biolink:NamedThing D-serine transport The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0002932 biolink:NamedThing tendon sheath development The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move. got7fsn_ti hjd 2012-04-23T02:11:22Z biological_process owl:Class
GO:0043319 biolink:NamedThing positive regulation of cytotoxic T cell degranulation Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation. got7fsn_ti positive regulation of cytotoxic T lymphocyte degranulation|positive regulation of cytotoxic T cell granule exocytosis|activation of cytotoxic T cell degranulation|stimulation of cytotoxic T cell degranulation|positive regulation of cytotoxic T lymphocyte granule exocytosis|up-regulation of cytotoxic T cell degranulation|positive regulation of cytotoxic T-lymphocyte granule exocytosis|positive regulation of cytotoxic T-lymphocyte degranulation|up regulation of cytotoxic T cell degranulation|positive regulation of cytotoxic T-cell granule exocytosis|upregulation of cytotoxic T cell degranulation|positive regulation of cytotoxic T-cell degranulation biological_process owl:Class
GO:1990758 biolink:NamedThing mitotic sister chromatid biorientation The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step in metaphase plate congression. got7fsn_ti vw 2015-06-02T12:36:17Z biological_process owl:Class
GO:0051010 biolink:NamedThing microtubule plus-end binding Binding to the plus end of a microtubule. got7fsn_ti molecular_function owl:Class
GO:0098904 biolink:NamedThing regulation of AV node cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti regulation of AV node cardiac muscle cell action potential|regulation of atrioventricular node cardiac muscle cell action potential tb 2011-11-10T08:58:56Z biological_process owl:Class
GO:1903752 biolink:NamedThing positive regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. got7fsn_ti upregulation of intrinsic apoptotic signaling pathway in response to H2O2|up-regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|up regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|up regulation of H2O2-induced intrinsic apoptotic signaling pathway|activation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|positive regulation of H2O2-induced intrinsic apoptotic signaling pathway|positive regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|upregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway in response to H2O2|upregulation of H2O2-induced intrinsic apoptotic signaling pathway|upregulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|activation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|up-regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|up-regulation of intrinsic apoptotic signaling pathway in response to H2O2|up regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|up regulation of intrinsic apoptotic signaling pathway in response to H2O2|activation of H2O2-induced intrinsic apoptotic signaling pathway|up-regulation of H2O2-induced intrinsic apoptotic signaling pathway|activation of intrinsic apoptotic signaling pathway in response to H2O2 krc 2014-12-12T23:04:46Z biological_process owl:Class
GO:0062001 biolink:NamedThing negative regulation of cardiac endothelial to mesenchymal transition Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac endothelial to mesenchymal transition. got7fsn_ti dph 2018-02-16T16:36:48Z biological_process owl:Class
CHEBI:16480 biolink:NamedThing got7fsn_ti owl:Class
GO:0010826 biolink:NamedThing negative regulation of centrosome duplication Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized. got7fsn_ti biological_process owl:Class
GO:1904415 biolink:NamedThing regulation of xenophagy Any process that modulates the frequency, rate or extent of xenophagy. got7fsn_ti An example of this is mouse Tbk1 (UniProt symbol, Q9WUN2) in PMID:21617041 (inferred from mutant phenotype). pad 2015-06-29T12:30:47Z biological_process owl:Class
GO:1900104 biolink:NamedThing regulation of hyaluranon cable assembly Any process that modulates the frequency, rate or extent of hyaluranon cable assembly. got7fsn_ti regulation of HA cable assembly yaf 2012-02-16T01:00:41Z biological_process owl:Class
GO:0046551 biolink:NamedThing retinal cone cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal cone cell. A retinal cone cell is one of the two photoreceptor subtypes in a camera-type eye. got7fsn_ti biological_process owl:Class
GO:1901995 biolink:NamedThing positive regulation of meiotic cell cycle phase transition Any process that activates or increases the frequency, rate or extent of meiotic cell cycle phase transition. got7fsn_ti positive regulation of cell cycle transition|up-regulation of meiotic cell cycle phase transition|up regulation of cell cycle transition|activation of meiotic cell cycle phase transition|upregulation of meiotic cell cycle phase transition|up-regulation of cell cycle transition|activation of cell cycle transition|up regulation of meiotic cell cycle phase transition|upregulation of cell cycle transition jl 2013-03-19T16:15:08Z biological_process owl:Class
GO:0004707 biolink:NamedThing MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. got7fsn_ti MBP kinase II activity|SAPK|ERK|myelin basic protein kinase activity|MBP kinase I activity|MAP kinase 2 activity|ERK2|MAPK|mitogen activated kinase activity|MAP kinase 1 activity|stress-activated protein kinase activity|ATP:protein phosphotransferase (MAPKK-activated) activity|SAP kinase activity|extracellular signal-regulated kinase activity|ERK1|mitogen-activated protein kinase activity|stress-activated kinase activity GO:0016908|GO:0016909|GO:0008339|GO:0008338 Reactome:R-HSA-5654562|Reactome:R-HSA-451366|MetaCyc:2.7.11.24-RXN|Reactome:R-HSA-5654566|Reactome:R-HSA-198733|Reactome:R-HSA-9626832|Reactome:R-HSA-111898|Reactome:R-HSA-5654560|Reactome:R-HSA-5654565|EC:2.7.11.24|Reactome:R-HSA-445079|KEGG_REACTION:R00162|Reactome:R-HSA-73722 molecular_function owl:Class
GO:0031566 biolink:NamedThing actomyosin contractile ring maintenance The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle. got7fsn_ti contractile ring maintenance involved in cell cycle cytokinesis|cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle biological_process owl:Class
GO:0001546 biolink:NamedThing preantral ovarian follicle growth Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation. got7fsn_ti biological_process owl:Class
GO:0021656 biolink:NamedThing rhombomere 2 structural organization The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 2 structural organisation biological_process owl:Class
GO:1990101 biolink:NamedThing DnaA-oriC complex A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle. got7fsn_ti DnaA-DNA complex bhm 2013-05-14T12:07:04Z cellular_component owl:Class
GO:1900162 biolink:NamedThing negative regulation of phospholipid scramblase activity Any process that stops, prevents or reduces the frequency, rate or extent of phospholipid scramblase activity. got7fsn_ti down-regulation of phospholipid scramblase activity|down regulation of phospholipid scramblase activity|inhibition of phospholipid scramblase activity|downregulation of phospholipid scramblase activity rph 2012-03-08T10:57:23Z biological_process owl:Class
GO:0050903 biolink:NamedThing leukocyte activation-dependent arrest The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation. got7fsn_ti biological_process owl:Class
GO:0097558 biolink:NamedThing left ventral flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc. got7fsn_ti left ventral cilium Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T13:26:51Z cellular_component owl:Class
GO:2000789 biolink:NamedThing positive regulation of venous endothelial cell fate commitment Any process that activates or increases the frequency, rate or extent of venous endothelial cell fate commitment. got7fsn_ti bf 2011-06-24T01:26:19Z biological_process owl:Class
GO:0039677 biolink:NamedThing exit of virus from host cell nucleus via nuclear envelope disassembly The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus. got7fsn_ti exit of virus from host cell nucleus via nuclear envelope breakdown bf 2013-09-25T14:10:03Z VZ:2176 biological_process owl:Class
GO:1902388 biolink:NamedThing ceramide 1-phosphate transfer activity Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti intermembrane ceramide 1-phosphate transfer activity|ceramide 1-phosphate carrier activity|ceramide 1-phosphate transporter activity uh 2013-09-05T05:57:55Z Reactome:R-HSA-5339535 molecular_function owl:Class
GO:1902389 biolink:NamedThing ceramide 1-phosphate transport The directed movement of a ceramide 1-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti uh 2013-09-05T06:02:35Z biological_process owl:Class
GO:1905776 biolink:NamedThing positive regulation of DNA helicase activity Any process that activates or increases the frequency, rate or extent of ATP-dependent DNA helicase activity. got7fsn_ti up-regulation of DNA helicase activity|upregulation of ATP-dependent DNA helicase activity|positive regulation of ATP-dependent DNA helicase activity|upregulation of DNA helicase activity|up regulation of DNA helicase activity|up regulation of ATP-dependent DNA helicase activity|activation of DNA helicase activity|activation of ATP-dependent DNA helicase activity|up-regulation of ATP-dependent DNA helicase activity rb 2013-10-15T21:20:10Z GO:1902451 biological_process owl:Class
GO:0003429 biolink:NamedThing growth plate cartilage chondrocyte morphogenesis The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized. got7fsn_ti dph 2009-12-22T12:22:24Z biological_process owl:Class
GO:0031039 biolink:NamedThing macronucleus A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell. got7fsn_ti Wikipedia:Macronucleus cellular_component owl:Class
GO:0090641 biolink:NamedThing microsporidian-type endospore The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins. got7fsn_ti Microsporidian biology uses the term endospore differently than GO:0043593 endospore coat which is for a spore formed inside of another cell. Microsporidian endospore refers to the inner layer of the spore wall itself. tb 2015-05-04T14:17:06Z cellular_component owl:Class
GO:0061050 biolink:NamedThing regulation of cell growth involved in cardiac muscle cell development Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state. got7fsn_ti dph 2010-02-25T01:05:16Z biological_process owl:Class
GO:0043318 biolink:NamedThing negative regulation of cytotoxic T cell degranulation Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation. got7fsn_ti negative regulation of cytotoxic T-cell granule exocytosis|negative regulation of cytotoxic T lymphocyte granule exocytosis|negative regulation of cytotoxic T lymphocyte degranulation|down regulation of cytotoxic T cell degranulation|down-regulation of cytotoxic T cell degranulation|negative regulation of cytotoxic T-cell degranulation|downregulation of cytotoxic T cell degranulation|negative regulation of cytotoxic T-lymphocyte degranulation|negative regulation of cytotoxic T cell granule exocytosis|negative regulation of cytotoxic T-lymphocyte granule exocytosis|inhibition of cytotoxic T cell degranulation biological_process owl:Class
GO:0090387 biolink:NamedThing phagolysosome assembly involved in apoptotic cell clearance The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance. got7fsn_ti tb 2010-10-27T10:57:39Z biological_process owl:Class
GO:0090386 biolink:NamedThing phagosome maturation involved in apoptotic cell clearance A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome. got7fsn_ti tb 2010-10-27T10:57:39Z biological_process owl:Class
GO:0120111 biolink:NamedThing neuron projection cytoplasm All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. got7fsn_ti krc 2017-11-01T18:58:12Z cellular_component owl:Class
GO:0070308 biolink:NamedThing lens fiber cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a lens fiber cell. A lens fiber cell is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye. got7fsn_ti lens fibre cell fate commitment biological_process owl:Class
GO:0009780 biolink:NamedThing photosynthetic NADP+ reduction An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions. got7fsn_ti biological_process owl:Class
GO:0043375 biolink:NamedThing CD8-positive, alpha-beta T cell lineage commitment The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell. got7fsn_ti CD8-positive, alpha-beta T-lymphocyte lineage commitment|CD8-positive, alpha-beta T cell fate commitment|CD8-positive, alpha-beta T-cell lineage commitment|CD8-positive, alpha-beta T lymphocyte lineage commitment biological_process owl:Class
GO:0021714 biolink:NamedThing inferior olivary nucleus morphogenesis The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements. got7fsn_ti inferior olive morphogenesis biological_process owl:Class
GO:0099626 biolink:NamedThing voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels. got7fsn_ti voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels molecular_function owl:Class
GO:0033364 biolink:NamedThing mast cell secretory granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a mast cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. got7fsn_ti mast cell secretory granule organisation|mast cell secretory granule organization and biogenesis|mast cell secretory granule maturation biological_process owl:Class
GO:2000371 biolink:NamedThing regulation of DNA topoisomerase (ATP-hydrolyzing) activity Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. got7fsn_ti regulation of topoisomerase II|regulation of deoxyribonucleic topoisomerase activity|regulation of DNA topoisomerase IV activity|regulation of DNA topoisomerase type II activity|regulation of DNA topoisomerase (ATP-hydrolysing)|regulation of type II DNA topoisomerase activity|regulation of deoxyribonucleate topoisomerase|regulation of topoisomerase|regulation of DNA topoisomerase II mah 2011-02-09T02:35:27Z biological_process owl:Class
GO:0015194 biolink:NamedThing L-serine transmembrane transporter activity Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. got7fsn_ti threonine/serine:sodium symporter activity|L-serine permease activity|L-serine transporter activity|serine transporter activity GO:1905361|GO:0015511 Reactome:R-HSA-8932980 molecular_function owl:Class
GO:0015825 biolink:NamedThing L-serine transport The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-serine import tb 2012-10-01T11:10:51Z GO:0090479 biological_process owl:Class
GO:0003142 biolink:NamedThing cardiogenic plate morphogenesis The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field. got7fsn_ti cardiac crescent morphogenesis tb 2009-09-22T04:12:18Z biological_process owl:Class
GO:0099521 biolink:NamedThing ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. got7fsn_ti ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential|ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential molecular_function owl:Class
GO:0000506 biolink:NamedThing glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. got7fsn_ti GPI-GnT complex|GPI-GlcNAc transferase complex|GPI-N-acetylglucosaminyltransferase complex Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. cellular_component owl:Class
GO:0035322 biolink:NamedThing mesenchymal cell migration involved in limb bud formation The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud. got7fsn_ti bf 2010-02-24T02:05:14Z biological_process owl:Class
GO:0090496 biolink:NamedThing mesenchyme migration involved in limb bud formation The migration of mesenchymal tissue that contributes to the formation of a limb bud. got7fsn_ti tb 2012-10-17T12:04:20Z biological_process owl:Class
GO:1901218 biolink:NamedThing negative regulation of holin activity Any process that stops, prevents or reduces the frequency, rate or extent of holin activity. got7fsn_ti antiholin activity|down-regulation of holin activity|downregulation of holin activity|down regulation of holin activity|phage antiholin|inhibition of holin activity bf 2012-08-06T10:48:00Z biological_process owl:Class
GO:0098684 biolink:NamedThing photoreceptor ribbon synapse A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. got7fsn_ti dos 2017-02-05T16:26:27Z cellular_component owl:Class
CL:0000748 biolink:NamedThing got7fsn_ti owl:Class
GO:1901250 biolink:NamedThing negative regulation of lung goblet cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of lung goblet cell differentiation. got7fsn_ti downregulation of lung goblet cell differentiation|down-regulation of lung goblet cell differentiation|down-regulation of pulmonary goblet cell differentiation|downregulation of pulmonary goblet cell differentiation|inhibition of pulmonary goblet cell differentiation|down regulation of pulmonary goblet cell differentiation|inhibition of lung goblet cell differentiation|negative regulation of pulmonary goblet cell differentiation|down regulation of lung goblet cell differentiation vk 2012-08-08T08:59:36Z biological_process owl:Class
GO:0048390 biolink:NamedThing intermediate mesoderm morphogenesis The process in which the anatomical structures of the intermediate mesoderm are generated and organized. got7fsn_ti biological_process owl:Class
GO:0043322 biolink:NamedThing negative regulation of natural killer cell degranulation Any process that stops, prevents, or reduces the rate of natural killer cell degranulation. got7fsn_ti downregulation of natural killer cell degranulation|down regulation of natural killer cell degranulation|negative regulation of NK cell degranulation|inhibition of natural killer cell degranulation|down-regulation of natural killer cell degranulation|negative regulation of natural killer cell granule exocytosis|negative regulation of NK cell granule exocytosis biological_process owl:Class
GO:0062094 biolink:NamedThing stomach development The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. got7fsn_ti dph 2018-11-20T18:15:45Z biological_process owl:Class
GO:0031459 biolink:NamedThing ABC-type glycine betaine transporter activity Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in). got7fsn_ti glycine betaine ABC transporter|ATPase-coupled glycine betaine transporter activity|ATP-dependent glycine betaine transporter activity|N-trimethylglycine-transporting ATPase activity|glycine betaine-transporting ATPase activity RHEA:32783 molecular_function owl:Class
GO:0060166 biolink:NamedThing olfactory pit development The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx. got7fsn_ti biological_process owl:Class
GO:1903352 biolink:NamedThing L-ornithine transmembrane transport The directed movement of L-ornithine across a membrane. got7fsn_ti pr 2014-08-20T13:01:38Z biological_process owl:Class
GO:0009317 biolink:NamedThing acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. got7fsn_ti ACCase complex cellular_component owl:Class
GO:0060419 biolink:NamedThing heart growth The increase in size or mass of the heart. got7fsn_ti biological_process owl:Class
GO:0030993 biolink:NamedThing axonemal heterotrimeric kinesin-II complex A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme. got7fsn_ti cellular_component owl:Class
GO:0010797 biolink:NamedThing regulation of multivesicular body size involved in endosome transport Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles. got7fsn_ti biological_process owl:Class
GO:0017154 biolink:NamedThing semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0035066 biolink:NamedThing positive regulation of histone acetylation Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein. got7fsn_ti up-regulation of histone acetylation|up regulation of histone acetylation|stimulation of histone acetylation|upregulation of histone acetylation|activation of histone acetylation biological_process owl:Class
GO:0009672 biolink:NamedThing auxin:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in). got7fsn_ti auxin:hydrogen symporter activity molecular_function owl:Class
GO:0021916 biolink:NamedThing inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis. got7fsn_ti inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors biological_process owl:Class
GO:0021917 biolink:NamedThing somatic motor neuron fate commitment The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons. got7fsn_ti biological_process owl:Class
GO:0033336 biolink:NamedThing caudal fin development The process whose specific outcome is the progression of the caudal fin over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0070183 biolink:NamedThing mitochondrial tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA in a mitochondrion, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
CHEBI:36915 biolink:NamedThing got7fsn_ti owl:Class
GO:1902233 biolink:NamedThing negative regulation of positive thymic T cell selection Any process that stops, prevents or reduces the frequency, rate or extent of positive thymic T cell selection. got7fsn_ti negative regulation of positive thymic T lymphocyte selection|down-regulation of positive thymic T lymphocyte selection|inhibition of positive thymic T cell selection|down regulation of positive thymic T-cell selection|downregulation of positive thymic T-lymphocyte selection|downregulation of positive thymic T lymphocyte selection|down regulation of positive thymic T cell selection|inhibition of positive thymic T lymphocyte selection|down-regulation of positive thymic T-cell selection|negative regulation of positive thymic T-cell selection|inhibition of positive thymic T-lymphocyte selection|down-regulation of positive thymic T cell selection|downregulation of positive thymic T-cell selection|down-regulation of positive thymic T-lymphocyte selection|inhibition of positive thymic T-cell selection|negative regulation of positive thymic T-lymphocyte selection|down regulation of positive thymic T lymphocyte selection|downregulation of positive thymic T cell selection|down regulation of positive thymic T-lymphocyte selection lb 2013-06-14T11:19:15Z biological_process owl:Class
GO:0031062 biolink:NamedThing positive regulation of histone methylation Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones. got7fsn_ti stimulation of histone methylation|activation of histone methylation|up-regulation of histone methylation|up regulation of histone methylation|upregulation of histone methylation biological_process owl:Class
GO:1905081 biolink:NamedThing positive regulation of cerebellar neuron development Any process that activates or increases the frequency, rate or extent of cerebellar neuron development. got7fsn_ti activation of cerebellar neuron development|upregulation of cerebellar neuron development|up regulation of cerebellar neuron development|up-regulation of cerebellar neuron development hjd 2016-03-24T19:45:35Z biological_process owl:Class
GO:0035203 biolink:NamedThing regulation of lamellocyte differentiation Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. got7fsn_ti biological_process owl:Class
GO:0061056 biolink:NamedThing sclerotome development The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra. got7fsn_ti dph 2010-03-02T12:12:40Z biological_process owl:Class
GO:1904840 biolink:NamedThing positive regulation of male germ-line stem cell asymmetric division Any process that activates or increases the frequency, rate or extent of male germ-line stem cell asymmetric division. got7fsn_ti up regulation of male germ-line stem cell renewal|activation of male germ-line stem cell renewal|up-regulation of male germ-line stem cell asymmetric division|upregulation of male germ-line stem cell asymmetric division|up-regulation of male germ-line stem cell renewal|activation of male germ-line stem cell asymmetric division|up regulation of male germ-line stem cell asymmetric division|upregulation of male germ-line stem cell renewal|positive regulation of male germ-line stem cell renewal sl 2015-12-05T00:28:46Z biological_process owl:Class
GO:0009376 biolink:NamedThing HslUV protease complex A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. got7fsn_ti ClpYQ protease complex cellular_component owl:Class
GO:0004176 biolink:NamedThing ATP-dependent peptidase activity Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. got7fsn_ti ATP-dependent proteolysis https://github.com/geneontology/go-ontology/issues/21612 GO:0004280 Reactome:R-HSA-9698929 molecular_function owl:Class
GO:0043211 biolink:NamedThing ABC-type carbohydrate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane. got7fsn_ti ATPase-coupled carbohydrate transmembrane transporter activity|carbohydrate ABC transporter|ATP-dependent carbohydrate transmembrane transporter activity|carbohydrate-transporting ATPase activity https://github.com/geneontology/go-ontology/issues/17289 molecular_function owl:Class
GO:0034219 biolink:NamedThing carbohydrate transmembrane transport The process in which a carbohydrate is transported across a membrane. got7fsn_ti transmembrane carbohydrate transport|carbohydrate membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. biological_process owl:Class
GO:0061737 biolink:NamedThing leukotriene signaling pathway A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-leukotriene interaction and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti dph 2015-09-15T12:58:21Z biological_process owl:Class
GO:1905468 biolink:NamedThing regulation of clathrin-coated pit assembly Any process that modulates the frequency, rate or extent of clathrin-coated pit assembly. got7fsn_ti regulation of clathrin-coated pit formation|regulation of coated pit formation|regulation of coated pit assembly bf 2016-09-20T10:04:37Z biological_process owl:Class
GO:0036479 biolink:NamedThing peroxidase inhibitor activity Binds to and stops, prevents or reduces the activity of peroxidase. got7fsn_ti GO:0036479 is reserved for cases when the inhibitor directly interacts with the peroxidase. When inhibition of peroxidase activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'negative regulation of peroxidase activity ; GO:2000469'. bf 2014-07-24T10:14:45Z molecular_function owl:Class
GO:0075009 biolink:NamedThing germ tube formation Development of slender tubular outgrowth first produced by most symbiont spores immediately following germination on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti germ tube formation on or near host biological_process owl:Class
GO:0086086 biolink:NamedThing voltage-gated potassium channel activity involved in AV node cell action potential repolarization Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated potassium channel activity involved in AV node cardiac muscle cell action potential repolarization|voltage-gated potassium channel activity involved in atrioventricular node cardiac muscle cell action potential dph 2011-11-22T01:26:32Z molecular_function owl:Class
GO:0086049 biolink:NamedThing membrane repolarization during AV node cell action potential The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. got7fsn_ti membrane repolarization involved in regulation of AV node cardiac muscle cell action potential|membrane repolarization involved in regulation of atrioventricular node cardiac muscle cell action potential dph 2011-11-16T11:43:38Z biological_process owl:Class
GO:2001233 biolink:NamedThing regulation of apoptotic signaling pathway Any process that modulates the frequency, rate or extent of apoptotic signaling pathway. got7fsn_ti regulation of apoptotic signalling pathway pr 2011-11-24T01:20:49Z biological_process owl:Class
GO:0005948 biolink:NamedThing acetolactate synthase complex A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate. got7fsn_ti acetohydroxyacid synthase complex See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. cellular_component owl:Class
GO:0060091 biolink:NamedThing kinocilium A nonmotile primary cilium that is found at the apical surface of auditory receptor cells. The kinocilium is surrounded by actin-based stereocilia. got7fsn_ti Wikipedia:Kinocilium cellular_component owl:Class
GO:0019183 biolink:NamedThing histamine-gated chloride channel complex A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts. got7fsn_ti cellular_component owl:Class
GO:1904381 biolink:NamedThing Golgi apparatus mannose trimming Any protein alpha-1,2-demannosylation that takes place in the Golgi apparatus. got7fsn_ti glycoprotein mannose trimming in Golgi apparatus|mannose trimming in Golgi|mannose trimming in Golgi apparatus|glycoprotein mannose trimming in Golgi complex|protein alpha-1,2-demannosylation in Golgi complex|protein alpha-1,2-demannosylation in Golgi apparatus|glycoprotein mannose trimming in Golgi ribbon|protein alpha-1,2-demannosylation in Golgi ribbon|mannose trimming in cis-Golgi bf 2015-06-23T09:42:06Z biological_process owl:Class
GO:0071004 biolink:NamedThing U2-type prespliceosome A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. got7fsn_ti major prespliceosome|GT-AG prespliceosome|mammalian U2-type spliceosomal complex A|yeast U2-type spliceosomal complex B mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0072008 biolink:NamedThing glomerular mesangial cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the glomerular mesangial cells of the kidney as it progresses from its formation to the mature state. got7fsn_ti mah 2010-01-25T01:59:33Z biological_process owl:Class
GO:0030989 biolink:NamedThing dynein-driven meiotic oscillatory nuclear movement Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein. got7fsn_ti horsetail nuclear movement|HNM|horsetail movement Dynein-driven meiotic oscillatory nuclear movement precedes meiotic recombination. biological_process owl:Class
GO:0004666 biolink:NamedThing prostaglandin-endoperoxide synthase activity Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. got7fsn_ti prostaglandin synthase activity|PG synthetase activity|prostaglandin synthetase activity|prostaglandin endoperoxide synthetase activity|prostaglandin G/H synthase activity|(PG)H synthase activity|(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity|fatty acid cyclooxygenase activity EC:1.14.99.1|MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN|Reactome:R-HSA-140355|Reactome:R-HSA-2309787|RHEA:23728 molecular_function owl:Class
GO:0061825 biolink:NamedThing podosome core The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. got7fsn_ti dph 2017-01-14T14:42:45Z cellular_component owl:Class
GO:0097239 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus. got7fsn_ti pr 2012-02-02T12:28:46Z biological_process owl:Class
GO:0061444 biolink:NamedThing endocardial cushion cell development The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state. got7fsn_ti dph 2012-03-13T09:07:46Z biological_process owl:Class
GO:0021769 biolink:NamedThing orbitofrontal cortex development The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe. got7fsn_ti biological_process owl:Class
GO:0030420 biolink:NamedThing establishment of competence for transformation The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation. got7fsn_ti biological_process owl:Class
GO:0009294 biolink:NamedThing DNA mediated transformation The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material. got7fsn_ti DNA-mediated transformation biological_process owl:Class
GO:0006284 biolink:NamedThing base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. got7fsn_ti BER Wikipedia:Base_excision_repair biological_process owl:Class
GO:0007571 biolink:NamedThing age-dependent general metabolic decline A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis. got7fsn_ti age-dependent decreased translational activity|age-dependent yeast cell size increase|age-dependent increased protein content|nucleolar size increase biological_process owl:Class
GO:1905393 biolink:NamedThing plant organ formation The process that gives rise to the plant organ. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti tb 2016-08-24T00:21:27Z biological_process owl:Class
GO:1902301 biolink:NamedThing galactarate transmembrane transporter activity Enables the transfer of galactaric acid anion (galactarate) from one side of a membrane to the other. got7fsn_ti D-galactarate transmembrane transporter activity|galactaric acid anion transmembrane transporter activity pr 2013-07-16T07:26:36Z GO:0042877 molecular_function owl:Class
GO:1902300 biolink:NamedThing galactarate transmembrane transport The process in which galactaric acid anion (galactarate) is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti galactaric acid anion transport|D-galactarate transport|galactarate transport pr 2013-07-16T07:11:45Z GO:0042871 biological_process owl:Class
GO:0044494 biolink:NamedThing envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism. got7fsn_ti jl 2012-02-01T01:29:25Z biological_process owl:Class
GO:0031163 biolink:NamedThing metallo-sulfur cluster assembly The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster. got7fsn_ti metallo-sulphur cluster assembly|metal-sulfur cluster assembly|metallo-sulfur cluster biosynthesis biological_process owl:Class
GO:0106023 biolink:NamedThing regulation of pupariation Any process that modulates the onset of pupariation. got7fsn_ti hjd 2017-05-24T19:31:39Z biological_process owl:Class
GO:0000223 biolink:NamedThing plasma membrane proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane. got7fsn_ti plasma membrane hydrogen ion-transporting ATPase V1 domain cellular_component owl:Class
GO:0033181 biolink:NamedThing plasma membrane proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the plasma membrane. got7fsn_ti plasma membrane hydrogen ion-transporting ATPase cellular_component owl:Class
GO:0071002 biolink:NamedThing U4atac/U6atac snRNP A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes. got7fsn_ti mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0071952 biolink:NamedThing conversion of O-phosphoseryl-tRNA to cysteinyl-tRNA The modification process that results in the conversion of O-phosphoserine charged on a tRNA(Cys) to cysteinyl-tRNA. got7fsn_ti Note that this process has been observed in some archaeal and bacterial species. mah 2010-10-08T12:02:00Z biological_process owl:Class
GO:0007361 biolink:NamedThing establishment of posterior gap gene boundaries Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps. got7fsn_ti biological_process owl:Class
GO:0007359 biolink:NamedThing posterior abdomen determination The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes. got7fsn_ti Note that this process is exemplified in insects by the actions of the knirps gene product. biological_process owl:Class
GO:1901890 biolink:NamedThing positive regulation of cell junction assembly Any process that activates or increases the frequency, rate or extent of cell junction assembly. got7fsn_ti up-regulation of cell junction assembly|up regulation of cell junction assembly|activation of cell junction assembly|upregulation of cell junction assembly tb 2013-02-06T19:40:46Z biological_process owl:Class
GO:0009427 biolink:NamedThing bacterial-type flagellum basal body, distal rod, L ring One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the outer membrane. got7fsn_ti flagellin-based flagellum basal body, distal rod, L ring|flagellar basal body, distal rod, L ring cellular_component owl:Class
GO:0001792 biolink:NamedThing polymeric immunoglobulin receptor activity Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0001790 biolink:NamedThing polymeric immunoglobulin binding Binding to a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes. got7fsn_ti molecular_function owl:Class
GO:0048702 biolink:NamedThing embryonic neurocranium morphogenesis The process in which the anatomical structures of the neurocranium are generated and organized during the embryonic phase. The neurocranium is the portion of the vertebrate skull surrounding the brain. got7fsn_ti embryonic chondrocranium morphogenesis|embryonic braincase morphogenesis biological_process owl:Class
GO:0021985 biolink:NamedThing neurohypophysis development The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. got7fsn_ti posterior pituitary gland development|neurophysis development|posterior pituitary development biological_process owl:Class
GO:0072495 biolink:NamedThing host cell Cajal body A class of nuclear body in the eukaryotic host cell, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA. The host is the larger of the organisms involved in a symbiotic interaction. got7fsn_ti host cell coiled body|coiled body of host mah 2010-12-15T11:51:12Z cellular_component owl:Class
GO:0032217 biolink:NamedThing riboflavin transmembrane transporter activity Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. got7fsn_ti riboflavin transporter activity RHEA:35015|Reactome:R-HSA-3165230 molecular_function owl:Class
GO:0036470 biolink:NamedThing tyrosine 3-monooxygenase activator activity Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity. got7fsn_ti tyrosine hydroxylase activator activity|TH activator activity bf 2014-07-21T11:06:49Z molecular_function owl:Class
GO:0004511 biolink:NamedThing tyrosine 3-monooxygenase activity Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. got7fsn_ti L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|tyrosine hydroxylase activity|tyrosine 3-hydroxylase activity|L-tyrosine hydroxylase activity Reactome:R-HSA-209823|EC:1.14.16.2|RHEA:18201|MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN molecular_function owl:Class
GO:1902437 biolink:NamedThing positive regulation of male mating behavior Any process that activates or increases the frequency, rate or extent of male mating behavior. got7fsn_ti activation of male mating behavior|upregulation of male mating behavior|up regulation of male mating behavior|up-regulation of male mating behavior mm2 2013-10-09T15:50:14Z biological_process owl:Class
GO:0140584 biolink:NamedThing chromatin extrusion motor activity A DNA translocase activity that folds chromosomal DNA and catalytically extends the newly formed loop, driven by ATP hydrolysis. got7fsn_ti chromatin extrusion activity https://github.com/geneontology/go-ontology/issues/21647|https://github.com/geneontology/go-ontology/issues/20204 pg 2021-02-01T13:42:08Z molecular_function owl:Class
GO:0140588 biolink:NamedThing chromatin looping A chromatin organization process that starts with the loading of an extrusion motor (by an SMC family complex) onto the chromatin, followed by chromatin extrusion that stops at loop anchoring sites on the chromosome. got7fsn_ti chromatin folding|chromatin loop assembly https://github.com/geneontology/go-ontology/issues/20204 pg 2021-02-04T14:55:20Z biological_process owl:Class
GO:0097560 biolink:NamedThing left caudal flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body. got7fsn_ti left caudal cilium Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T13:29:44Z cellular_component owl:Class
GO:0033101 biolink:NamedThing cellular bud membrane The portion of the plasma membrane surrounding a cellular bud. got7fsn_ti cellular bud plasma membrane cellular_component owl:Class
GO:0042647 biolink:NamedThing proplastid nucleoid The region of a proplastid to which the DNA is confined. got7fsn_ti cellular_component owl:Class
GO:0009571 biolink:NamedThing proplastid stroma The space enclosed by the double membrane of a proplastid. got7fsn_ti cellular_component owl:Class
GO:0048398 biolink:NamedThing intermediate mesodermal cell fate specification The process in which a cell becomes capable of differentiating autonomously into an intermediate mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti intermediate mesoderm cell fate specification biological_process owl:Class
GO:0045899 biolink:NamedThing positive regulation of RNA polymerase II transcription preinitiation complex assembly Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. got7fsn_ti positive regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis|positive regulation of RNA polymerase II transcriptional pre-initiation complex assembly|positive regulation of RNA polymerase II transcriptional preinitiation complex formation|upregulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|activation of RNA polymerase II transcriptional preinitiation complex assembly|stimulation of RNA polymerase II transcriptional preinitiation complex assembly|up regulation of RNA polymerase II transcriptional preinitiation complex assembly|up-regulation of RNA polymerase II transcriptional preinitiation complex assembly biological_process owl:Class
GO:0150064 biolink:NamedThing vertebrate eye-specific patterning Early postnatal vertebrate developmental process, during which axons of retinal ganglion cells (RGCs), transmitting overlapping inputs from both eyes, segregate into distinct eye-specific non-overlapping regions in the dorsal lateral geniculate nucleus (dLGN) of the thalamus. got7fsn_ti vertebrate eye-specific segregation|eye-specific segregation|binocular vision development|eye-specific patterning bc 2018-07-23T10:39:44Z biological_process owl:Class
GO:0050969 biolink:NamedThing detection of chemical stimulus involved in magnetoreception The series of events involved in magnetoception in which a chemical stimulus is received and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states. got7fsn_ti sensory transduction of chemical stimulus during magnetoreception|magnetoreception, sensory transduction of chemical stimulus|magnetoreception, detection of chemical stimulus|magnetoreception, sensory detection of chemical stimulus|sensory detection of chemical stimulus during magnetoreception|magnetoception, sensory transduction of chemical stimulus biological_process owl:Class
GO:0009547 biolink:NamedThing plastid ribosome A ribosome contained within a plastid. got7fsn_ti cellular_component owl:Class
GO:1904877 biolink:NamedThing positive regulation of DNA ligase activity Any process that activates or increases the frequency, rate or extent of DNA ligase activity. got7fsn_ti up-regulation of DNA ligase activity|upregulation of DNA ligase activity|activation of DNA ligase activity|up regulation of DNA ligase activity rl 2015-12-18T18:35:44Z biological_process owl:Class
GO:0006266 biolink:NamedThing DNA ligation The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase. got7fsn_ti biological_process owl:Class
GO:1903761 biolink:NamedThing negative regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. got7fsn_ti inhibition of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|inhibition of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|down-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|downregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|down regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|down regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|downregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|downregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|inhibition of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|negative regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|downregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|inhibition of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|down regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|downregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|down-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|negative regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|negative regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|negative regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|down-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|down-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|down regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|down regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|down-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|inhibition of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential rl 2014-12-19T12:02:09Z biological_process owl:Class
GO:0098915 biolink:NamedThing membrane repolarization during ventricular cardiac muscle cell action potential The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. got7fsn_ti electrocardiogram T wave|ventricular repolarization|regulation of ventricular cardiac muscle repolarization biological_process owl:Class
GO:0015184 biolink:NamedThing L-cystine transmembrane transporter activity Enables the transfer of L-cystine from one side of a membrane to the other. got7fsn_ti L-cystine transporter activity|cystine/diaminopimelate porter activity Reactome:R-HSA-5340130 molecular_function owl:Class
GO:0015811 biolink:NamedThing L-cystine transport The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0060128 biolink:NamedThing corticotropin hormone secreting cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin. got7fsn_ti adrenocorticotrophic hormone secreting cell differentiation|adrenocorticotropic hormone secreting cell differentiation|corticotrope differentiation|corticotrophin hormone secreting cell differentiation|corticotroph differentiation biological_process owl:Class
GO:0045022 biolink:NamedThing early endosome to late endosome transport The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs. got7fsn_ti biological_process owl:Class
GO:0038122 biolink:NamedThing C-C motif chemokine 5 receptor activity Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti RANTES receptor activity|small inducible cytokine A5 receptor activity|CCL5 receptor activity bf 2012-03-22T01:36:00Z molecular_function owl:Class
GO:0035689 biolink:NamedThing chemokine (C-C motif) ligand 5 signaling pathway A series of molecular signals initiated by the binding of the chemokine CCL5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CCL5-mediated signaling pathway|RANTES-mediated signaling pathway|chemokine (C-C motif) ligand 5 signalling pathway bf 2011-02-24T12:56:13Z biological_process owl:Class
GO:2000077 biolink:NamedThing negative regulation of type B pancreatic cell development Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development. got7fsn_ti negative regulation of pancreatic beta cell development|negative regulation of pancreatic B cell development tb 2010-08-27T11:21:17Z biological_process owl:Class
GO:0090718 biolink:NamedThing adaptive immune effector response An adaptive immune response that involves one or more immune effector processes and takes place during the effector phase of the adaptive immune response. got7fsn_ti tb 2016-11-11T12:37:26Z biological_process owl:Class
GO:0051415 biolink:NamedThing microtubule nucleation by interphase microtubule organizing center The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation. got7fsn_ti IMTOC-mediated microtubule nucleation during interphase|interphase microtubule organizing center-mediated microtubule nucleation during interphase|microtubule nucleation during interphase by interphase microtubule organizing center|microtubule nucleation during interphase by IMTOC|interphase microtubule nucleation by interphase microtubule organizing center|interphase microtubule nucleation by interphase microtubule organising centre biological_process owl:Class
GO:0007533 biolink:NamedThing mating type switching The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus. got7fsn_ti mating type switching and recombination biological_process owl:Class
GO:0045697 biolink:NamedThing regulation of synergid differentiation Any process that modulates the frequency, rate or extent of synergid cell differentiation. got7fsn_ti regulation of synergid cell differentiation biological_process owl:Class
CL:0000160 biolink:NamedThing got7fsn_ti owl:Class
GO:0019973 biolink:NamedThing interleukin-13 binding Binding to interleukin-13. got7fsn_ti IL-13 binding molecular_function owl:Class
GO:0000815 biolink:NamedThing ESCRT III complex An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes. got7fsn_ti endosomal sorting complex required for transport cellular_component owl:Class
GO:0060701 biolink:NamedThing negative regulation of ribonuclease activity Any process that decreases the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. got7fsn_ti dph 2009-06-08T02:49:46Z biological_process owl:Class
GO:0060336 biolink:NamedThing negative regulation of interferon-gamma-mediated signaling pathway Any process that decreases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor. got7fsn_ti negative regulation of interferon-gamma-mediated signalling pathway|negative regulation of immune interferon-mediated signaling pathway|negative regulation of type II interferon-mediated signaling pathway|negative regulation of type II IFN-mediated signaling pathway|negative regulation of gamma-interferon-mediated signaling pathway biological_process owl:Class
GO:0036395 biolink:NamedThing pancreatic amylase secretion The controlled release of amylase from a cell of the pancreas. got7fsn_ti bf 2013-07-01T13:42:34Z biological_process owl:Class
GO:0061451 biolink:NamedThing retrotrapezoid nucleus development The progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration. got7fsn_ti dph 2012-07-19T12:38:30Z biological_process owl:Class
GO:0031204 biolink:NamedThing posttranslational protein targeting to membrane, translocation The process in which a protein translocates through the ER membrane posttranslationally. got7fsn_ti protein translocation during posttranslational protein targeting to membrane|posttranslational protein membrane targeting, translocation biological_process owl:Class
GO:0060129 biolink:NamedThing thyroid-stimulating hormone-secreting cell differentiation The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a thyroid-stimulating hormone-secreting cell. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid-stimulating hormone, thyrotrophin. got7fsn_ti TSH-secreting cell differentiation|thyrotroph differentiation|thyroid stimulating hormone secreting cell differentiation|beta-basophil differentiation|thyrotrope differentiation biological_process owl:Class
GO:1905221 biolink:NamedThing positive regulation of platelet formation Any process that activates or increases the frequency, rate or extent of platelet formation. got7fsn_ti up regulation of platelet extrusion|up regulation of platelet formation|up-regulation of platelet formation|positive regulation of platelet extrusion|upregulation of platelet extrusion|activation of platelet formation|up-regulation of platelet extrusion|activation of platelet extrusion|upregulation of platelet formation sl 2016-06-06T22:16:02Z biological_process owl:Class
CHEBI:48433 biolink:NamedThing got7fsn_ti owl:Class
GO:0061211 biolink:NamedThing mesonephric collecting duct development The process whose specific outcome is the progression of a collecting duct in the mesonephros over time, from its formation to the mature structure. The collecting duct regulates water, electrolyte and acid-base balance. The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder. got7fsn_ti dph 2010-08-17T03:25:51Z biological_process owl:Class
GO:0120191 biolink:NamedThing negative regulation of termination of RNA polymerase II transcription Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase II transcription. got7fsn_ti repression of termination of RNA polymerase II transcription|down regulation of RNA 3'-end formation by RNA polymerase II|negative regulation of RNA polymerase II transcription termination factor activity|downregulation of RNA 3'-end formation by RNA polymerase II|down regulation of transcription termination from RNA polymerase II promoter|down-regulation of termination of RNA polymerase II transcription|negative regulation of RNA polymerase II transcription termination|negative regulation of transcription termination from Pol II promoter|downregulation of transcription termination from Pol II promoter|downregulation of RNA polymerase II transcription termination factor activity|down regulation of transcription termination from Pol II promoter|down regulation of RNA polymerase II transcription termination|down regulation of termination of RNA polymerase II transcription|downregulation of transcription termination from RNA polymerase II promoter|down-regulation of RNA polymerase II transcription termination|down regulation of RNA polymerase II transcription termination factor activity|down-regulation of RNA polymerase II transcription termination factor activity|downregulation of termination of RNA polymerase II transcription|repression of transcription termination from Pol II promoter|down-regulation of transcription termination from RNA polymerase II promoter|repression of RNA polymerase II transcription termination factor activity|negative regulation of transcription termination from RNA polymerase II promoter|down-regulation of transcription termination from Pol II promoter|negative regulation of RNA 3'-end formation by RNA polymerase II|repression of RNA polymerase II transcription termination|repression of RNA 3'-end formation by RNA polymerase II|down-regulation of RNA 3'-end formation by RNA polymerase II|downregulation of RNA polymerase II transcription termination|repression of transcription termination from RNA polymerase II promoter krc 2018-07-18T15:43:40Z biological_process owl:Class
GO:1990512 biolink:NamedThing Cry-Per complex Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms. got7fsn_ti An example of this is Cry1 in mouse (P97784) in PMID:24855952 (inferred from physical interaction). bhm 2014-10-08T10:53:07Z cellular_component owl:Class
GO:0008270 biolink:NamedThing zinc ion binding Binding to a zinc ion (Zn). got7fsn_ti Zn binding|zinc binding molecular_function owl:Class
GO:0032515 biolink:NamedThing negative regulation of phosphoprotein phosphatase activity Any process that stops or reduces the activity of a phosphoprotein phosphatase. got7fsn_ti down regulation of phosphoprotein phosphatase activity|down regulation of protein phosphatase 2 activity|inhibition of protein phosphatase 3 activity|down regulation of protein phosphatase 3 activity|inhibition of protein phosphatase type 2A activity|down-regulation of phosphoprotein phosphatase activity|downregulation of calcineurin activity|downregulation of protein phosphatase 3 activity|regulation of protein phosphatase 3 activity|downregulation of protein phosphatase type 2B activity|down-regulation of protein phosphatase type 2A activity|negative regulation of calcineurin activity|inhibition of phosphoprotein phosphatase activity|downregulation of protein phosphatase type 2A activity|negative regulation of protein phosphatase 2 activity|downregulation of protein phosphatase 2 activity|downregulation of phosphoprotein phosphatase activity|negative regulation of protein phosphatase type 2B activity|inhibition of calcineurin activity|down-regulation of protein phosphatase type 2B activity|negative regulation of protein phosphatase type 2A activity|down regulation of protein phosphatase type 2B activity|down regulation of protein phosphatase type 2A activity|inhibition of protein phosphatase 2 activity|down regulation of calcineurin activity|inhibition of protein phosphatase type 2B activity GO:0034048|GO:0032513 biological_process owl:Class
GO:1990433 biolink:NamedThing CSL-Notch-Mastermind transcription factor complex A DNA-binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes. got7fsn_ti CSL-NotchIC-MASTERMIND complex bhm 2014-07-30T14:41:43Z cellular_component owl:Class
GO:0033040 biolink:NamedThing sour taste receptor activity Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste. got7fsn_ti molecular_function owl:Class
GO:0001581 biolink:NamedThing detection of chemical stimulus involved in sensory perception of sour taste The series of events required for a sour taste stimulus to be received and converted to a molecular signal. got7fsn_ti sensory transduction of chemical stimulus during perception of sour taste|sensory transduction of sour taste|sensory detection of chemical stimulus during perception of sour taste|perception of sour taste, detection of chemical stimulus|sour taste detection|sensory detection of sour taste|perception of sour taste, sensory transduction of chemical stimulus biological_process owl:Class
NCBITaxon:5740 biolink:NamedThing got7fsn_ti owl:Class
GO:0098944 biolink:NamedThing postsynaptic recycling endosome membrane The lipid bilayer surrounding a postsynaptic recycling endosome. got7fsn_ti cellular_component owl:Class
GO:0098837 biolink:NamedThing postsynaptic recycling endosome A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation. got7fsn_ti postsynaptic endosomal recycling compartment|postsynaptic recycling outpost cellular_component owl:Class
GO:2000558 biolink:NamedThing positive regulation of immunoglobulin production in mucosal tissue Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue. got7fsn_ti positive regulation of antibody production in mucosal tissue ebc 2011-04-03T07:52:17Z biological_process owl:Class
GO:0010169 biolink:NamedThing thioglucosidase complex A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds. got7fsn_ti myrosinase complex cellular_component owl:Class
GO:0007297 biolink:NamedThing ovarian follicle cell migration The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster. got7fsn_ti follicle cell migration biological_process owl:Class
GO:0009537 biolink:NamedThing proplastid The precursor of other plastids. got7fsn_ti cellular_component owl:Class
GO:0043243 biolink:NamedThing positive regulation of protein-containing complex disassembly Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. got7fsn_ti activation of protein complex disassembly|upregulation of protein complex disassembly|positive regulation of protein complex disassembly|up regulation of protein complex disassembly|stimulation of protein complex disassembly|up-regulation of protein complex disassembly biological_process owl:Class
GO:0006449 biolink:NamedThing regulation of translational termination Any process that modulates the frequency, rate or extent of translational termination. got7fsn_ti biological_process owl:Class
GO:0198738 biolink:NamedThing cell-cell signaling by wnt Any process that mediates the transfer of information from one cell to another, medaited by a wnt family protein ligand. This process includes wnt signal transduction in the receiving cell, release of wnt ligand from a secreting cell as well as any processes that actively facilitate wnt transport and presentation to receptor on the recieving cell. got7fsn_ti biological_process owl:Class
GO:0039673 biolink:NamedThing evasion by virus of host dendritic cell activity Any process by which a virus avoids the effects mediated by the host organism's dendritic cells. got7fsn_ti evasion by virus of host dendritic cell response|impairing dendritic cell function by virus|modulation of host dendritic cell activity by virus bf 2013-09-25T11:18:51Z biological_process owl:Class
CL:0000451 biolink:NamedThing got7fsn_ti owl:Class
GO:0015210 biolink:NamedThing uracil transmembrane transporter activity Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other. got7fsn_ti uracil/uridine permease activity molecular_function owl:Class
GO:1903791 biolink:NamedThing uracil transmembrane transport The process in which uracil is transported across a membrane. got7fsn_ti vw 2015-01-12T10:15:25Z biological_process owl:Class
GO:0051740 biolink:NamedThing ethylene binding Binding to ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator. got7fsn_ti ethene binding molecular_function owl:Class
GO:0008358 biolink:NamedThing maternal determination of anterior/posterior axis, embryo The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos. got7fsn_ti biological_process owl:Class
GO:0002024 biolink:NamedThing diet induced thermogenesis The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system. got7fsn_ti biological_process owl:Class
GO:0000738 biolink:NamedThing DNA catabolic process, exonucleolytic The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides. got7fsn_ti DNA degradation, exonucleolytic|exonucleolytic degradation of DNA|DNA breakdown, exonucleolytic biological_process owl:Class
GO:0010847 biolink:NamedThing regulation of chromatin assembly Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus. got7fsn_ti biological_process owl:Class
GO:1990682 biolink:NamedThing CSF1-CSF1R complex A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand. got7fsn_ti M-CSF:C-FMS complex|M-CSF:CSF1R complex|M-CSF:FMS complex|CSF1:C-FMS complex|macrophage colony-stimulating factor:receptor complex bf 2015-03-10T12:23:03Z cellular_component owl:Class
GO:0019284 biolink:NamedThing L-methionine salvage from S-adenosylmethionine The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine. got7fsn_ti L-methionine synthesis from S-adenosylmethionine|L-methionine formation from S-adenosylmethionine biological_process owl:Class
UBERON:0002108 biolink:NamedThing got7fsn_ti owl:Class
GO:0003414 biolink:NamedThing chondrocyte morphogenesis involved in endochondral bone morphogenesis The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized. got7fsn_ti dph 2009-12-22T08:42:55Z biological_process owl:Class
GO:0019013 biolink:NamedThing viral nucleocapsid The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle. got7fsn_ti core|nucleocapsid GO:0019014 cellular_component owl:Class
GO:0021957 biolink:NamedThing corticospinal tract morphogenesis Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract. got7fsn_ti CST axonogenesis|corticospinal tract axonogenesis biological_process owl:Class
GO:0014003 biolink:NamedThing oligodendrocyte development The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. got7fsn_ti oligodendrocyte cell development biological_process owl:Class
GO:2000553 biolink:NamedThing positive regulation of T-helper 2 cell cytokine production Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production. got7fsn_ti positive regulation of Th2 cell cytokine production ebc 2011-04-03T07:32:58Z biological_process owl:Class
GO:0034494 biolink:NamedThing microneme lumen The volume enclosed by the microneme membrane. got7fsn_ti cellular_component owl:Class
GO:0030709 biolink:NamedThing border follicle cell delamination The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration. got7fsn_ti border cell delamination biological_process owl:Class
GO:0001530 biolink:NamedThing lipopolysaccharide binding Binding to a lipopolysaccharide. got7fsn_ti endotoxin binding|LPS binding molecular_function owl:Class
GO:0005702 biolink:NamedThing polytene chromosome weak point A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization. got7fsn_ti constriction cellular_component owl:Class
GO:0015567 biolink:NamedThing alkane transmembrane transporter activity Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds. got7fsn_ti molecular_function owl:Class
GO:0015895 biolink:NamedThing alkane transport The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds. got7fsn_ti biological_process owl:Class
GO:0090166 biolink:NamedThing Golgi disassembly A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance. got7fsn_ti tb 2009-12-08T09:15:11Z biological_process owl:Class
GO:0048313 biolink:NamedThing Golgi inheritance The partitioning of Golgi apparatus between daughter cells at cell division. got7fsn_ti Golgi partitioning|Golgi division biological_process owl:Class
GO:0061857 biolink:NamedThing endoplasmic reticulum stress-induced pre-emptive quality control The response to endoplasimic reticulum stress in which nascent proteins are degraded by attenuation of their translocation into the ER followed by rerouting to the cytosol without cleavage of the signal peptide, and subsequent degradation by the proteasome. got7fsn_ti ER stress-indiced pre-emptive quality control|ER pQC dph 2017-03-28T13:05:03Z biological_process owl:Class
GO:1990476 biolink:NamedThing synaptic vesicle, resting pool A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation causes a saturating degree of vesicular turnover. 50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool. got7fsn_ti resting pool of synaptic vesicles|reserve pool of synaptic vesicles pr 2014-09-02T09:12:37Z cellular_component owl:Class
GO:0031941 biolink:NamedThing filamentous actin A two-stranded helical polymer of the protein actin. got7fsn_ti F-actin Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. Wikipedia:Actin cellular_component owl:Class
GO:1990909 biolink:NamedThing Wnt signalosome A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. got7fsn_ti LRP6 signalosome|LRP5/6 signalosome|Wnt-LRP5/6 signalosome|Wnt signalosome complex Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription. bf 2015-12-07T14:04:23Z cellular_component owl:Class
GO:0030719 biolink:NamedThing P granule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes. got7fsn_ti polar granule organisation|P granule organization and biogenesis|polar granule organization and biogenesis GO:0048114 biological_process owl:Class
GO:0003327 biolink:NamedThing type B pancreatic cell fate commitment The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. got7fsn_ti pancreatic B cell fate commitment dph 2009-11-02T08:31:24Z biological_process owl:Class
GO:0070648 biolink:NamedThing formin-nucleated actin cable An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth. got7fsn_ti mah 2009-05-12T02:09:57Z cellular_component owl:Class
GO:0044012 biolink:NamedThing histone acetyltransferase activity (H2A-K9 specific) Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9). got7fsn_ti histone lysine N-acetyltransferase activity (H2A-K9 specific) molecular_function owl:Class
GO:0043978 biolink:NamedThing histone H2A-K9 acetylation The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone. got7fsn_ti histone H2A acetylation at K9 biological_process owl:Class
GO:1990647 biolink:NamedThing C/EBP complex A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities. got7fsn_ti C/EBPalpha homodimer complex|C/EBP transcription factor complex|C/EBPbeta homodimer complex|C/EBPalpha complex|C/EBPbeta complex|C/EBP homodimer complex An example of this is Cebpa in rat (P05554) in PMID:8657121 (inferred from direct assay). bhm 2015-02-19T11:00:09Z cellular_component owl:Class
GO:0034647 biolink:NamedThing histone H3-tri/di/monomethyl-lysine-4 demethylase activity Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone demethylase activity (H3-trimethyl-K4 specific)|histone demethylase activity (H3-K4-me3 specific)|histone H3-K4me2 demethylase activity|histone H3K4me2 demethylase activity|H3K4me3 demethylase activity|histone H3-K4me3 demethylase activity https://github.com/geneontology/go-ontology/issues/21089 EC:1.14.11.67|RHEA:60208 molecular_function owl:Class
GO:0034721 biolink:NamedThing histone H3-K4 demethylation, trimethyl-H3-K4-specific The modification of histone H3 by the removal of a methyl group from a trimetylated lysine at position 4 of the histone. got7fsn_ti H3K4 demethylation (me3)|histone H3-K4 tridemethylation biological_process owl:Class
GO:0007400 biolink:NamedThing neuroblast fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus. got7fsn_ti neuroblast cell fate determination|neuroblast identity determination GO:0043348|GO:0007408|GO:0043347 biological_process owl:Class
GO:0030256 biolink:NamedThing type I protein secretion system complex A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space. got7fsn_ti ABC translocator complex cellular_component owl:Class
GO:0110131 biolink:NamedThing Aim21-Tda2 complex A complex that localizes to actin cortical patches at sites of endocytosis and negatively regulates barbed end F-actin assembly, resulting in the generation of free actin pools. The Aim21-Tda2 complex is necessary for efficient endocytosis and balancing the distribution of actin between patches and cables. got7fsn_ti Aim21/Tda2 complex kmv 2018-10-09T21:08:36Z cellular_component owl:Class
GO:0030837 biolink:NamedThing negative regulation of actin filament polymerization Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization. got7fsn_ti down regulation of actin filament polymerization|downregulation of actin filament polymerization|negative regulation of actin polymerization and/or depolymerization|down-regulation of actin filament polymerization|inhibition of actin filament polymerization|negative regulation of actin polymerization Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835'). biological_process owl:Class
GO:0060971 biolink:NamedThing embryonic heart tube left/right pattern formation The pattern specification process that results in the subdivision of the left/right axis of the embryonic heart tube in space to define an area or volume in which specific patterns of cell differentiation will take place. got7fsn_ti dph 2009-10-06T10:22:11Z biological_process owl:Class
GO:0005335 biolink:NamedThing serotonin:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in). got7fsn_ti serotonin transmembrane transporter activity|serotonin:sodium:chloride symporter activity|sodium/serotonin symporter activity GO:0015222|GO:0005336 Reactome:R-HSA-444008|RHEA:51196 molecular_function owl:Class
GO:1904347 biolink:NamedThing regulation of small intestine smooth muscle contraction Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction. got7fsn_ti sl 2015-06-11T21:37:34Z biological_process owl:Class
GO:0035311 biolink:NamedThing wing cell fate specification The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment. got7fsn_ti biological_process owl:Class
GO:1901232 biolink:NamedThing regulation of convergent extension involved in axis elongation Any process that modulates the frequency, rate or extent of convergent extension involved in axis elongation. got7fsn_ti vk 2012-08-07T14:21:46Z biological_process owl:Class
GO:1990251 biolink:NamedThing nuclear exosome focus An nuclear body involved in nuclear mRNA surveilllance. Contains at least Mmi1, or an ortholog of it, and the nuclear exosome. got7fsn_ti Mmi1 nuclear focus|nuclear body https://github.com/geneontology/go-ontology/issues/19063 al 2013-12-09T12:07:46Z cellular_component owl:Class
GO:0042907 biolink:NamedThing xanthine transmembrane transporter activity Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. got7fsn_ti molecular_function owl:Class
GO:0042906 biolink:NamedThing xanthine transport The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids. got7fsn_ti xanthine transmembrane transport biological_process owl:Class
GO:0035920 biolink:NamedThing negative regulation of high voltage-gated calcium channel activity in other organism Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. got7fsn_ti down-regulation of high voltage-gated calcium channel activity in other organism|inhibition of high voltage-gated calcium channel activity in other organism|negative regulation of high voltage gated calcium channel activity in other organism|negative regulation of high voltage-dependent calcium channel activity in other organism|downregulation of high voltage-gated calcium channel activity in other organism bf 2011-07-01T12:00:23Z biological_process owl:Class
GO:0003263 biolink:NamedThing cardioblast proliferation The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti dph 2009-10-15T02:13:05Z biological_process owl:Class
GO:1905296 biolink:NamedThing negative regulation of neural crest cell fate specification Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell fate specification. got7fsn_ti inhibition of neural crest cell fate specification|down regulation of neural crest cell fate specification|downregulation of neural crest cell fate specification|down-regulation of neural crest cell fate specification rl 2016-06-28T15:14:49Z biological_process owl:Class
GO:1903946 biolink:NamedThing negative regulation of ventricular cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of ventricular cardiac muscle cell action potential. got7fsn_ti downregulation of ventricular cardiac muscle cell action potential|inhibition of ventricular cardiac muscle cell action potential|down regulation of ventricular cardiac muscle cell action potential|down-regulation of ventricular cardiac muscle cell action potential nc 2015-02-20T14:31:55Z biological_process owl:Class
GO:0045092 biolink:NamedThing interleukin-18 receptor complex A protein complex that binds interleukin-18; comprises an alpha and a beta subunit. got7fsn_ti IL-18 receptor complex cellular_component owl:Class
GO:0043589 biolink:NamedThing skin morphogenesis The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue. got7fsn_ti biological_process owl:Class
GO:0035016 biolink:NamedThing elongation of arista lateral The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions. got7fsn_ti biological_process owl:Class
GO:0061772 biolink:NamedThing xenobiotic transport across blood-nerve barrier The directed movement of a xenobiotic through the blood-nerve barrier. got7fsn_ti drug transport across perineurial barrier|drug transport across blood-nerve barrier dph 2016-07-09T09:59:59Z biological_process owl:Class
GO:1901505 biolink:NamedThing carbohydrate derivative transmembrane transporter activity Enables the transfer of carbohydrate derivative from one side of a membrane to the other. got7fsn_ti carbohydrate derivative transporter activity pr 2012-10-17T10:31:22Z molecular_function owl:Class
GO:1901264 biolink:NamedThing carbohydrate derivative transport The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti bf 2012-08-16T14:51:22Z biological_process owl:Class
GO:0055009 biolink:NamedThing atrial cardiac muscle tissue morphogenesis The process in which the anatomical structure of cardiac atrium muscle is generated and organized. got7fsn_ti atrial myocardium morphogenesis|atrial heart muscle morphogenesis|cardiac atrium muscle morphogenesis biological_process owl:Class
GO:0046606 biolink:NamedThing negative regulation of centrosome cycle Any process that stops, prevents, or reduces the frequency, rate or extent of the centrosome cycle. got7fsn_ti inhibition of centrosome cycle|down-regulation of centrosome cycle|downregulation of centrosome cycle|down regulation of centrosome cycle biological_process owl:Class
GO:0008622 biolink:NamedThing epsilon DNA polymerase complex A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair. got7fsn_ti DNA polymerase epsilon complex cellular_component owl:Class
GO:2000262 biolink:NamedThing positive regulation of blood coagulation, common pathway Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway. got7fsn_ti mah 2010-11-23T11:42:48Z biological_process owl:Class
GO:0015578 biolink:NamedThing mannose transmembrane transporter activity Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. got7fsn_ti mannose permease activity GO:0015589 molecular_function owl:Class
GO:0015761 biolink:NamedThing mannose transmembrane transport The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. got7fsn_ti mannose transport biological_process owl:Class
GO:0042532 biolink:NamedThing negative regulation of tyrosine phosphorylation of STAT protein Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. got7fsn_ti inhibition of tyrosine phosphorylation of Stat6 protein|down-regulation of tyrosine phosphorylation of Stat3 protein|down regulation of tyrosine phosphorylation of Stat3 protein|down regulation of tyrosine phosphorylation of Stat6 protein|negative regulation of tyrosine phosphorylation of Stat7 protein|negative regulation of tyrosine phosphorylation of Stat2 protein|inhibition of tyrosine phosphorylation of Stat1 protein|downregulation of tyrosine phosphorylation of Stat4 protein|down regulation of tyrosine phosphorylation of Stat2 protein|inhibition of tyrosine phosphorylation of Stat7 protein|inhibition of tyrosine phosphorylation of Stat4 protein|negative regulation of tyrosine phosphorylation of Stat6 protein|down-regulation of tyrosine phosphorylation of Stat5 protein|inhibition of tyrosine phosphorylation of Stat5 protein|down regulation of tyrosine phosphorylation of Stat4 protein|down regulation of tyrosine phosphorylation of Stat7 protein|down regulation of tyrosine phosphorylation of Stat1 protein|downregulation of tyrosine phosphorylation of Stat2 protein|downregulation of tyrosine phosphorylation of STAT protein|downregulation of tyrosine phosphorylation of Stat3 protein|down-regulation of tyrosine phosphorylation of Stat6 protein|downregulation of tyrosine phosphorylation of Stat6 protein|negative regulation of tyrosine phosphorylation of Stat4 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|negative regulation of tyrosine phosphorylation of Stat3 protein|down-regulation of tyrosine phosphorylation of Stat1 protein|downregulation of tyrosine phosphorylation of Stat1 protein|down-regulation of tyrosine phosphorylation of Stat4 protein|down regulation of tyrosine phosphorylation of STAT protein|downregulation of tyrosine phosphorylation of Stat7 protein|inhibition of tyrosine phosphorylation of Stat3 protein|down regulation of tyrosine phosphorylation of Stat5 protein|inhibition of tyrosine phosphorylation of Stat2 protein|down-regulation of tyrosine phosphorylation of Stat7 protein|inhibition of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of Stat1 protein|downregulation of tyrosine phosphorylation of Stat5 protein|down-regulation of tyrosine phosphorylation of STAT protein|down-regulation of tyrosine phosphorylation of Stat2 protein GO:0042530|GO:0042521|GO:0042524|GO:0042527|GO:0042514|GO:0042518|GO:0042512 biological_process owl:Class
GO:0002070 biolink:NamedThing epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. got7fsn_ti biological_process owl:Class
GO:1900259 biolink:NamedThing regulation of RNA-directed 5'-3' RNA polymerase activity Any process that modulates the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. got7fsn_ti regulation of ribonucleic acid replicase activity|regulation of transcriptase|regulation of ribonucleic replicase activity|regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|regulation of RNA synthetase activity|regulation of RNA replicase activity|regulation of Q-beta replicase activity|regulation of PB1 proteins|regulation of RNA-dependent RNA polymerase activity|regulation of RNA-dependent RNA replicase activity|regulation of phage f2 replicase|regulation of RDRP|regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|regulation of PB2 proteins|regulation of RNA-directed RNA polymerase activity|regulation of RNA nucleotidyltransferase (RNA-directed) activity|regulation of 3D polymerase activity|regulation of polymerase L|regulation of ribonucleic synthetase activity|regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity tb 2012-04-03T11:01:53Z biological_process owl:Class
GO:1905941 biolink:NamedThing positive regulation of gonad development Any process that activates or increases the frequency, rate or extent of gonad development. got7fsn_ti up-regulation of gonad development|activation of gonadogenesis|upregulation of gonad development|positive regulation of gonadogenesis|up-regulation of gonadogenesis|up regulation of gonadogenesis|activation of gonad development|upregulation of gonadogenesis|up regulation of gonad development hbye 2017-02-09T17:02:08Z biological_process owl:Class
GO:0016082 biolink:NamedThing synaptic vesicle priming A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. got7fsn_ti Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015) biological_process owl:Class
GO:0075188 biolink:NamedThing regulation of hyphopodium formation Any process that modulates the frequency, rate or extent of symbiont hyphopodium formation on or near its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti regulation of hyphopodium formation on or near host Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0040016 biolink:NamedThing embryonic cleavage The first few specialized divisions of an activated animal egg. got7fsn_ti biological_process owl:Class
GO:0015243 biolink:NamedThing cycloheximide transmembrane transporter activity Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes. got7fsn_ti cycloheximide transporter activity molecular_function owl:Class
GO:0015901 biolink:NamedThing cycloheximide transport The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes. got7fsn_ti biological_process owl:Class
GO:0035278 biolink:NamedThing miRNA mediated inhibition of translation The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. got7fsn_ti down regulation of translation involved in gene silencing by miRNA|downregulation of translation involved in gene silencing by miRNA|down-regulation of translation involved in gene silencing by miRNA|miRNA-mediated gene silencing, negative regulation of translation|gene silencing by miRNA, negative regulation of translation|negative regulation of translation involved in gene silencing by microRNA|inhibition of translation involved in gene silencing by miRNA biological_process owl:Class
GO:0070239 biolink:NamedThing regulation of activated T cell autonomous cell death Any process that modulates the occurrence or rate of activated T cell autonomous cell death. got7fsn_ti regulation of activated cell autonomous cell death|regulation of activated T cell apoptosis|regulation of ACAD|regulation of activated T lymphocyte autonomous cell death|regulation of activated T-lymphocyte autonomous cell death|regulation of activated T-cell autonomous cell death biological_process owl:Class
GO:2000266 biolink:NamedThing regulation of blood coagulation, intrinsic pathway Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway. got7fsn_ti mah 2010-11-23T11:45:40Z biological_process owl:Class
GO:0140275 biolink:NamedThing MIB complex A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1. got7fsn_ti mitochondrial intermembrane space bridging complex|mitofilin complex pg 2018-10-01T17:10:27Z cellular_component owl:Class
GO:0031305 biolink:NamedThing integral component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to mitochondrial inner membrane cellular_component owl:Class
GO:0046545 biolink:NamedThing development of primary female sexual characteristics The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion. got7fsn_ti biological_process owl:Class
GO:0021720 biolink:NamedThing superior olivary nucleus formation The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. got7fsn_ti biological_process owl:Class
GO:0097410 biolink:NamedThing hippocampal interneuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron. got7fsn_ti pr 2012-11-04T10:58:28Z biological_process owl:Class
GO:0000353 biolink:NamedThing formation of quadruple SL/U4/U5/U6 snRNP Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA. got7fsn_ti Note that this step is analogous to 5' splice site selection in cis-splicing. biological_process owl:Class
GO:0045291 biolink:NamedThing mRNA trans splicing, SL addition The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body. got7fsn_ti nuclear mRNA trans splicing, SL addition|nuclear mRNA trans splicing, spliced leader addition biological_process owl:Class
GO:0021901 biolink:NamedThing early neuron fate commitment in forebrain The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain. got7fsn_ti biological_process owl:Class
GO:0006782 biolink:NamedThing protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. got7fsn_ti protoporphyrinogen IX synthesis|protoporphyrinogen IX biosynthesis|protoporphyrinogen IX formation|protoporphyrinogen IX anabolism biological_process owl:Class
GO:0000731 biolink:NamedThing DNA synthesis involved in DNA repair Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template. got7fsn_ti mitotic DNA repair synthesis|DNA synthesis during DNA repair|DNA repair synthesis biological_process owl:Class
GO:0015014 biolink:NamedThing heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan. got7fsn_ti heparan sulfate proteoglycan chain elongation|heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis|heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism|heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparan sulfate proteoglycan formation, polysaccharide chain formation|heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis|heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process|heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis biological_process owl:Class
GO:0015898 biolink:NamedThing amiloride transport The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic. got7fsn_ti biological_process owl:Class
GO:0035094 biolink:NamedThing response to nicotine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus. got7fsn_ti biological_process owl:Class
GO:0002044 biolink:NamedThing blood vessel endothelial cell migration involved in intussusceptive angiogenesis The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis. got7fsn_ti biological_process owl:Class
GO:1904857 biolink:NamedThing regulation of endothelial cell chemotaxis to vascular endothelial growth factor Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to vascular endothelial growth factor. got7fsn_ti rph 2015-12-16T11:47:44Z biological_process owl:Class
GO:0000086 biolink:NamedThing G2/M transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. got7fsn_ti mitotic G2/M transition biological_process owl:Class
GO:0099604 biolink:NamedThing ligand-gated calcium channel activity Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti molecular_function owl:Class
GO:0048081 biolink:NamedThing positive regulation of cuticle pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in the cuticle of an organism. got7fsn_ti upregulation of cuticle pigmentation|stimulation of cuticle pigmentation|up-regulation of cuticle pigmentation|activation of cuticle pigmentation|up regulation of cuticle pigmentation biological_process owl:Class
GO:0048499 biolink:NamedThing synaptic vesicle membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the membrane surrounding a synaptic vesicle. got7fsn_ti SLMV biogenesis|synaptic vesicle membrane organization and biogenesis|synaptic vesicle membrane organisation biological_process owl:Class
GO:0021641 biolink:NamedThing trochlear nerve structural organization The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle. got7fsn_ti CN IV structural organization|trochlear nerve structural organisation biological_process owl:Class
GO:0110164 biolink:NamedThing positive regulation of mitotic spindle elongation (spindle phase three) Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three). got7fsn_ti kmv 2019-08-12T15:32:20Z biological_process owl:Class
GO:1900727 biolink:NamedThing osmoregulated periplasmic glucan biosynthetic process The chemical reactions and pathways resulting in the formation of osmoregulated periplasmic glucan. got7fsn_ti osmoregulated periplasmic glucan anabolism|osmoregulated periplasmic glucan biosynthesis|osmoregulated periplasmic glucan synthesis|osmoregulated periplasmic glucan formation jl 2012-05-24T03:19:02Z biological_process owl:Class
GO:1904746 biolink:NamedThing negative regulation of apoptotic process involved in development Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development. got7fsn_ti downregulation of induction of apoptosis involved in development of an anatomical structure|negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure|inhibition of induction of apoptosis involved in development of an anatomical structure|down-regulation of apoptotic program involved in anatomical structure development|inhibition of apoptotic process involved in development|downregulation of apoptotic programmed cell death involved in development of an anatomical structure|down regulation of activation of apoptosis involved in development of an anatomical structure|inhibition of apoptosis activator activity involved in development of an anatomical structure|down regulation of apoptotic process involved in anatomical structure development|down regulation of apoptosis activator activity involved in anatomical structure development|down regulation of commitment to apoptosis involved in anatomical structure development|negative regulation of induction of apoptosis involved in anatomical structure development|down-regulation of induction of apoptosis involved in anatomical structure development|down regulation of type I programmed cell death involved in development of an anatomical structure|down regulation of programmed cell death by apoptosis involved in anatomical structure development|downregulation of induction of apoptosis involved in anatomical structure development|down-regulation of commitment to apoptosis involved in development of an anatomical structure|inhibition of apoptosis involved in anatomical structure development|negative regulation of commitment to apoptosis involved in development of an anatomical structure|downregulation of apoptotic cell death involved in development of an anatomical structure|negative regulation of type I programmed cell death involved in anatomical structure development|inhibition of apoptotic program involved in anatomical structure development|down regulation of apoptosis signaling involved in anatomical structure development|inhibition of apoptotic process involved in development of an anatomical structure|inhibition of apoptosis signaling involved in anatomical structure development|negative regulation of apoptosis involved in anatomical structure development|inhibition of apoptosis involved in development of an anatomical structure|inhibition of type I programmed cell death involved in anatomical structure development|down regulation of type I programmed cell death involved in anatomical structure development|inhibition of apoptotic cell death involved in development of an anatomical structure|negative regulation of apoptotic cell death involved in anatomical structure development|down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure|inhibition of programmed cell death by apoptosis involved in development of an anatomical structure|downregulation of apoptotic program involved in development of an anatomical structure|negative regulation of apoptosis activator activity involved in anatomical structure development|downregulation of apoptotic cell death involved in anatomical structure development|down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|down-regulation of apoptotic process involved in development|down regulation of apoptotic program involved in anatomical structure development|downregulation of apoptosis activator activity involved in anatomical structure development|downregulation of induction of apoptosis by p53 involved in anatomical structure development|negative regulation of induction of apoptosis involved in development of an anatomical structure|inhibition of apoptotic process involved in anatomical structure development|negative regulation of apoptosis signaling involved in development of an anatomical structure|negative regulation of apoptosis signaling involved in anatomical structure development|down regulation of induction of apoptosis involved in development of an anatomical structure|down regulation of signaling (initiator) caspase activity involved in anatomical structure development|negative regulation of apoptosis activator activity involved in development of an anatomical structure|downregulation of apoptotic process involved in development|down-regulation of activation of apoptosis involved in development of an anatomical structure|down-regulation of apoptosis signaling involved in development of an anatomical structure|down regulation of apoptotic programmed cell death involved in anatomical structure development|negative regulation of type I programmed cell death involved in development of an anatomical structure|down-regulation of type I programmed cell death involved in development of an anatomical structure|down regulation of activation of apoptosis involved in anatomical structure development|negative regulation of apoptotic process involved in anatomical structure development|down-regulation of apoptotic programmed cell death involved in anatomical structure development|down-regulation of apoptotic programmed cell death involved in development of an anatomical structure|inhibition of type I programmed cell death involved in development of an anatomical structure|downregulation of type I programmed cell death involved in anatomical structure development|down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure|negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure|downregulation of signaling (initiator) caspase activity involved in anatomical structure development|downregulation of apoptotic program involved in anatomical structure development|downregulation of apoptotic process involved in anatomical structure development|inhibition of activation of apoptosis involved in development of an anatomical structure|down regulation of induction of apoptosis by p53 involved in anatomical structure development|inhibition of induction of apoptosis by p53 involved in anatomical structure development|downregulation of commitment to apoptosis involved in anatomical structure development|downregulation of programmed cell death by apoptosis involved in anatomical structure development|downregulation of commitment to apoptosis involved in development of an anatomical structure|negative regulation of apoptotic program involved in development of an anatomical structure|negative regulation of apoptotic process involved in development of an anatomical structure|negative regulation of apoptotic cell death involved in development of an anatomical structure|down regulation of apoptosis signaling involved in development of an anatomical structure|down regulation of apoptotic program involved in development of an anatomical structure|inhibition of activation of apoptosis involved in anatomical structure development|inhibition of programmed cell death by apoptosis involved in anatomical structure development|down-regulation of apoptosis activator activity involved in anatomical structure development|inhibition of apoptosis signaling involved in development of an anatomical structure|negative regulation of apoptosis involved in development of an anatomical structure|inhibition of signaling (initiator) caspase activity involved in anatomical structure development|down-regulation of signaling (initiator) caspase activity involved in anatomical structure development|negative regulation of activation of apoptosis involved in development of an anatomical structure|negative regulation of commitment to apoptosis involved in anatomical structure development|negative regulation of signaling (initiator) caspase activity involved in anatomical structure development|negative regulation of programmed cell death by apoptosis involved in anatomical structure development|down regulation of apoptosis involved in development of an anatomical structure|down-regulation of activation of apoptosis involved in anatomical structure development|down-regulation of commitment to apoptosis involved in anatomical structure development|down regulation of apoptotic programmed cell death involved in development of an anatomical structure|negative regulation of apoptotic programmed cell death involved in anatomical structure development|down-regulation of apoptosis activator activity involved in development of an anatomical structure|downregulation of apoptotic process involved in development of an anatomical structure|downregulation of programmed cell death by apoptosis involved in development of an anatomical structure|downregulation of apoptosis signaling involved in development of an anatomical structure|down-regulation of apoptotic cell death involved in anatomical structure development|inhibition of apoptotic cell death involved in anatomical structure development|down-regulation of apoptosis signaling involved in anatomical structure development|inhibition of induction of apoptosis by p53 involved in development of an anatomical structure|downregulation of apoptosis involved in anatomical structure development|down-regulation of programmed cell death by apoptosis involved in anatomical structure development|down-regulation of apoptotic cell death involved in development of an anatomical structure|inhibition of apoptotic programmed cell death involved in development of an anatomical structure|downregulation of apoptosis signaling involved in anatomical structure development|down regulation of programmed cell death by apoptosis involved in development of an anatomical structure|downregulation of activation of apoptosis involved in development of an anatomical structure|down regulation of apoptotic process involved in development|negative regulation of apoptotic program involved in anatomical structure development|down regulation of apoptosis involved in anatomical structure development|down-regulation of apoptotic program involved in development of an anatomical structure|downregulation of type I programmed cell death involved in development of an anatomical structure|downregulation of activation of apoptosis involved in anatomical structure development|downregulation of induction of apoptosis by p53 involved in development of an anatomical structure|inhibition of apoptotic programmed cell death involved in anatomical structure development|down-regulation of apoptotic process involved in development of an anatomical structure|negative regulation of apoptotic programmed cell death involved in development of an anatomical structure|down regulation of commitment to apoptosis involved in development of an anatomical structure|down-regulation of induction of apoptosis involved in development of an anatomical structure|down-regulation of induction of apoptosis by p53 involved in anatomical structure development|downregulation of apoptosis involved in development of an anatomical structure|down regulation of induction of apoptosis by p53 involved in development of an anatomical structure|down-regulation of apoptosis involved in anatomical structure development|down regulation of apoptosis activator activity involved in development of an anatomical structure|downregulation of apoptosis activator activity involved in development of an anatomical structure|inhibition of induction of apoptosis involved in anatomical structure development|down regulation of apoptotic cell death involved in development of an anatomical structure|down regulation of induction of apoptosis involved in anatomical structure development|negative regulation of activation of apoptosis involved in anatomical structure development|inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure|down-regulation of apoptosis involved in development of an anatomical structure|down regulation of apoptotic cell death involved in anatomical structure development|inhibition of apoptotic program involved in development of an anatomical structure|inhibition of commitment to apoptosis involved in anatomical structure development|down regulation of apoptotic process involved in development of an anatomical structure|negative regulation of induction of apoptosis by p53 involved in anatomical structure development|inhibition of apoptosis activator activity involved in anatomical structure development|inhibition of commitment to apoptosis involved in development of an anatomical structure|downregulation of apoptotic programmed cell death involved in anatomical structure development|down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|down-regulation of type I programmed cell death involved in anatomical structure development|down-regulation of apoptotic process involved in anatomical structure development|downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure|negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure U4PR86 in PMID:22801495 inferred from mutant phenotype es 2015-10-19T14:12:27Z biological_process owl:Class
GO:0070560 biolink:NamedThing protein secretion by platelet The regulated release of proteins by a platelet or group of platelets. got7fsn_ti mah 2009-04-09T02:38:05Z biological_process owl:Class
GO:0002806 biolink:NamedThing negative regulation of antimicrobial peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis. got7fsn_ti down-regulation of antimicrobial peptide biosynthetic process|down regulation of antimicrobial peptide biosynthetic process|downregulation of antimicrobial peptide biosynthetic process|inhibition of antimicrobial peptide biosynthetic process biological_process owl:Class
GO:0002929 biolink:NamedThing MECO complex A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II. got7fsn_ti meta-coactivator complex hjd 2012-03-14T02:50:13Z cellular_component owl:Class
GO:0010657 biolink:NamedThing muscle cell apoptotic process A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle. got7fsn_ti muscle cell apoptosis biological_process owl:Class
GO:0042951 biolink:NamedThing arbutin transmembrane transporter activity Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042949 biolink:NamedThing arbutin transport The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1901235 biolink:NamedThing (R)-carnitine transmembrane transporter activity Enables the transfer of (R)-carnitine from one side of a membrane to the other. got7fsn_ti jl 2012-08-07T14:46:17Z RHEA:34959 molecular_function owl:Class
GO:1902270 biolink:NamedThing (R)-carnitine transmembrane transport The process in which (R)-carnitine is transported across a membrane. got7fsn_ti mcc 2013-06-28T21:57:39Z biological_process owl:Class
GO:0099530 biolink:NamedThing G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane. got7fsn_ti G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential molecular_function owl:Class
GO:0022024 biolink:NamedThing BMP signaling pathway involved in forebrain neuron fate commitment A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. got7fsn_ti bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment|BMP signalling pathway involved in forebrain neuron fate commitment|bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment biological_process owl:Class
GO:0033168 biolink:NamedThing conversion of ds siRNA to ss siRNA involved in RNA interference The process in which double-stranded siRNA molecules are converted to single-stranded siRNAs; required for the formation of a mature RITS complex during RNA interference. got7fsn_ti RNA interference, conversion of ds siRNA to ss siRNA biological_process owl:Class
GO:0005788 biolink:NamedThing endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum. got7fsn_ti ER lumen|endoplasmic reticulum cisterna|ER cisterna|cisternal lumen GO:0016022 cellular_component owl:Class
GO:0030998 biolink:NamedThing linear element A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex. got7fsn_ti cellular_component owl:Class
GO:0004878 biolink:NamedThing complement component C5a receptor activity Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti C5a anaphylatoxin receptor activity GO:0004944 molecular_function owl:Class
GO:1901017 biolink:NamedThing negative regulation of potassium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity. got7fsn_ti inhibition of potassium transporter activity|negative regulation of potassium transporter activity|downregulation of potassium transporter activity|down-regulation of potassium ion transmembrane transporter activity|inhibition of potassium ion transmembrane transporter activity|down-regulation of potassium transporter activity|down regulation of potassium transporter activity|down regulation of potassium ion transmembrane transporter activity|downregulation of potassium ion transmembrane transporter activity rl 2012-06-15T01:14:10Z biological_process owl:Class
GO:0110073 biolink:NamedThing regulation of apical constriction involved in ventral furrow formation Any process that modulates the frequency, rate or extent of apical constriction involved in ventral furrow formation. got7fsn_ti kmv 2017-12-06T17:30:29Z biological_process owl:Class
GO:0015227 biolink:NamedThing acyl carnitine transmembrane transporter activity Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane. got7fsn_ti acylcarnitine transporter activity Reactome:R-HSA-200424 molecular_function owl:Class
GO:1902616 biolink:NamedThing acyl carnitine transmembrane transport The process in which acyl carnitine is transported across a membrane. got7fsn_ti O-acylcarnitine transmembrane transport pr 2014-01-10T11:07:30Z biological_process owl:Class
GO:0003362 biolink:NamedThing noradrenergic neuron fate commitment involved in brainstem development The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem. got7fsn_ti dph 2009-12-03T10:56:16Z biological_process owl:Class
GO:0003361 biolink:NamedThing noradrenergic neuron differentiation involved in brainstem development The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem. got7fsn_ti dph 2009-12-03T10:53:30Z biological_process owl:Class
GO:0031663 biolink:NamedThing lipopolysaccharide-mediated signaling pathway A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. got7fsn_ti lipopolysaccharide-mediated signalling pathway|LPS-mediated signaling pathway biological_process owl:Class
GO:0071222 biolink:NamedThing cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. got7fsn_ti cellular response to LPS|cellular response to endotoxin mah 2009-12-03T01:29:29Z biological_process owl:Class
GO:0048341 biolink:NamedThing paraxial mesoderm formation The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. got7fsn_ti biological_process owl:Class
GO:0009506 biolink:NamedThing plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. got7fsn_ti plasmodesmata Wikipedia:Plasmodesma cellular_component owl:Class
GO:0045254 biolink:NamedThing pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). got7fsn_ti pyruvate dehydrogenase complex (lipoamide)|dihydrolipoyl dehydrogenase complex Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. GO:0009364 Wikipedia:Pyruvate_dehydrogenase_complex cellular_component owl:Class
GO:0098689 biolink:NamedThing latency-replication decision The process by which a virus switches on its replication cycle in an infected cell. The process is typically controlled by a genetic swtich controlled by environmental factors such as cell type, cell shape, the availability of nutrients, superinfection or exposure of infected cells to UV or various chemical stimuli. got7fsn_ti lytic switch|Latency-replication switch|proviral induction|reactivation of latent virus|proviral switch|prophage induction dos 2017-02-28T11:24:26Z VZ:3964 biological_process owl:Class
GO:0098965 biolink:NamedThing extracellular matrix of synaptic cleft The portion of the extracellular matrix that lies within the synaptic cleft. got7fsn_ti ECM of synaptic cleft|synaptic cleft ECM cellular_component owl:Class
GO:0032186 biolink:NamedThing cellular bud neck septin ring organization Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck. got7fsn_ti cellular bud neck septin ring organisation biological_process owl:Class
GO:0007105 biolink:NamedThing cytokinesis, site selection The process of marking the place where cytokinesis will occur. got7fsn_ti site selection involved in cell cycle cytokinesis|site selection involved in cytokinesis GO:0010687 biological_process owl:Class
CL:0000542 biolink:NamedThing got7fsn_ti owl:Class
GO:1901398 biolink:NamedThing regulation of transforming growth factor beta3 activation Any process that modulates the frequency, rate or extent of transforming growth factor beta3 activation. got7fsn_ti regulation of TGFB3 activation|regulation of TGF-beta 3 activation|regulation of TGFbeta 3 activation bf 2012-10-01T10:49:25Z biological_process owl:Class
GO:0003127 biolink:NamedThing detection of nodal flow The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry. got7fsn_ti tb 2009-09-22T02:45:48Z biological_process owl:Class
GO:0030128 biolink:NamedThing clathrin coat of endocytic vesicle A clathrin coat found on an endocytic vesicle. got7fsn_ti clathrin coat of endocytotic vesicle cellular_component owl:Class
GO:0032391 biolink:NamedThing photoreceptor connecting cilium The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone. got7fsn_ti photoreceptor cilium cellular_component owl:Class
GO:0099606 biolink:NamedThing microtubule plus-end directed mitotic chromosome migration The cell cycle process in which chromosomes that are laterally attached to one or more mitotic spindle microtubules migrate towards the spindle equator via plus-end-directed movement along the microtubules. This process is part of mitotic metaphase plate congression. got7fsn_ti plus-end directed chromosome gliding biological_process owl:Class
GO:1904732 biolink:NamedThing regulation of electron transfer activity Any process that modulates the frequency, rate or extent of electron transfer activity. got7fsn_ti regulation of amicyanin|regulation of electron transfer flavoprotein, group I|regulation of electron transfer flavoprotein|regulation of iron-sulfur electron transfer carrier|regulation of azurin|regulation of electron donor activity|regulation of electron transfer flavoprotein, group II|regulation of electron carrier, chlorophyll electron transport system|regulation of thioredoxin-like 2Fe-2S ferredoxin|regulation of 2Fe-2S electron transfer carrier|regulation of copper electron carrier|regulation of dicluster bacterial-type ferredoxin|regulation of adrenodoxin-type ferredoxin|regulation of redox-active disulfide bond electron carrier|regulation of chloroplast-type ferredoxin|regulation of rubredoxin|regulation of mononuclear iron electron carrier|regulation of monocluster bacterial-type ferredoxin|regulation of bacterial-type ferredoxin|regulation of high-potential iron-sulfur carrier|regulation of electron transporter activity|regulation of polyferredoxin|regulation of electron acceptor activity|regulation of small blue copper electron carrier|regulation of 3Fe-4S/4Fe-4S electron transfer carrier lb 2015-10-15T07:51:19Z biological_process owl:Class
GO:1903464 biolink:NamedThing negative regulation of mitotic cell cycle DNA replication Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication. got7fsn_ti down regulation of DNA replication involved in S phase involved in mitotic cell cycle|inhibition of mitotic cell cycle DNA replication|negative regulation of DNA replication involved in S phase involved in mitotic cell cycle|down regulation of mitotic nuclear cell cycle DNA replication|inhibition of DNA replication during S phase involved in mitotic cell cycle|down-regulation of DNA replication during S phase involved in mitotic cell cycle|negative regulation of DNA replication involved in S-phase involved in mitotic cell cycle|down-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|down-regulation of mitotic cell cycle DNA replication|inhibition of mitotic nuclear cell cycle DNA replication|down-regulation of mitotic nuclear cell cycle DNA replication|negative regulation of DNA replication during S phase involved in mitotic cell cycle|down-regulation of DNA replication involved in S-phase involved in mitotic cell cycle|down regulation of mitotic cell cycle DNA replication|negative regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|downregulation of mitotic nuclear cell cycle DNA replication|downregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|down-regulation of DNA replication involved in S phase involved in mitotic cell cycle|down regulation of DNA replication during S phase involved in mitotic cell cycle|negative regulation of mitotic nuclear cell cycle DNA replication|inhibition of nuclear cell cycle DNA replication involved in mitotic cell cycle|downregulation of DNA replication during S phase involved in mitotic cell cycle|inhibition of DNA replication involved in S phase involved in mitotic cell cycle|down regulation of DNA replication involved in S-phase involved in mitotic cell cycle|downregulation of DNA replication involved in S phase involved in mitotic cell cycle|down regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|inhibition of DNA replication involved in S-phase involved in mitotic cell cycle|downregulation of DNA replication involved in S-phase involved in mitotic cell cycle|downregulation of mitotic cell cycle DNA replication vw 2014-09-23T13:38:33Z biological_process owl:Class
GO:0046662 biolink:NamedThing regulation of oviposition Any process that modulates the frequency, rate or extent of the deposition of eggs, either fertilized or not, upon a surface or into a medium. got7fsn_ti regulation of post-mating oviposition GO:0048042 biological_process owl:Class
GO:0033283 biolink:NamedThing ATPase-coupled organic acid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out). got7fsn_ti organic acid-transporting ATPase activity|ATP-dependent organic acid transmembrane transporter activity molecular_function owl:Class
GO:1903465 biolink:NamedThing positive regulation of mitotic cell cycle DNA replication Any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication. got7fsn_ti positive regulation of DNA replication involved in S phase involved in mitotic cell cycle|up-regulation of DNA replication during S phase involved in mitotic cell cycle|positive regulation of mitotic nuclear cell cycle DNA replication|up-regulation of mitotic nuclear cell cycle DNA replication|activation of mitotic cell cycle DNA replication|activation of nuclear cell cycle DNA replication involved in mitotic cell cycle|up regulation of DNA replication involved in S-phase involved in mitotic cell cycle|positive regulation of DNA replication involved in S-phase involved in mitotic cell cycle|positive regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|positive regulation of DNA replication during S phase involved in mitotic cell cycle|up regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|upregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|upregulation of mitotic cell cycle DNA replication|up-regulation of mitotic cell cycle DNA replication|up-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle|up regulation of DNA replication during S phase involved in mitotic cell cycle|up-regulation of DNA replication involved in S phase involved in mitotic cell cycle|upregulation of mitotic nuclear cell cycle DNA replication|up regulation of DNA replication involved in S phase involved in mitotic cell cycle|activation of DNA replication involved in S phase involved in mitotic cell cycle|up regulation of mitotic nuclear cell cycle DNA replication|activation of mitotic nuclear cell cycle DNA replication|upregulation of DNA replication during S phase involved in mitotic cell cycle|activation of DNA replication during S phase involved in mitotic cell cycle|activation of DNA replication involved in S-phase involved in mitotic cell cycle|up-regulation of DNA replication involved in S-phase involved in mitotic cell cycle|up regulation of mitotic cell cycle DNA replication|upregulation of DNA replication involved in S-phase involved in mitotic cell cycle|upregulation of DNA replication involved in S phase involved in mitotic cell cycle vw 2014-09-23T13:38:41Z biological_process owl:Class
GO:1905138 biolink:NamedThing positive regulation of viral DNA genome packaging via site-specific sequence recognition Any process that activates or increases the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition. got7fsn_ti activation of viral DNA genome packaging via site-specific sequence recognition|up-regulation of viral DNA genome packaging via site-specific sequence recognition|upregulation of viral DNA genome packaging via site-specific sequence recognition|up regulation of viral DNA genome packaging via site-specific sequence recognition pr 2016-04-13T11:37:22Z biological_process owl:Class
GO:0060099 biolink:NamedThing regulation of phagocytosis, engulfment Any process that modulates the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. got7fsn_ti biological_process owl:Class
CL:0000899 biolink:NamedThing got7fsn_ti owl:Class
GO:0000295 biolink:NamedThing adenine nucleotide transmembrane transporter activity Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other. got7fsn_ti Reactome:R-HSA-389652 molecular_function owl:Class
GO:0051503 biolink:NamedThing adenine nucleotide transport The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1905261 biolink:NamedThing regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Any process that modulates the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination. got7fsn_ti se 2016-06-13T20:45:02Z biological_process owl:Class
GO:0007407 biolink:NamedThing neuroblast activation A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. got7fsn_ti GO:0043351|GO:0043352 biological_process owl:Class
GO:0097228 biolink:NamedThing sperm principal piece The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. got7fsn_ti pr 2012-01-25T01:27:27Z cellular_component owl:Class
GO:0019926 biolink:NamedThing peptidyl-tryptophan oxidation to tryptophyl quinone The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine. got7fsn_ti See also the biological process term 'peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone ; GO:0018069'. biological_process owl:Class
GO:0080139 biolink:NamedThing borate efflux transmembrane transporter activity Enables the transfer of borate from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti boron efflux transmembrane transporter activity dhl 2009-05-19T04:11:45Z molecular_function owl:Class
GO:0035445 biolink:NamedThing borate transmembrane transport The process in which borate is transported across a membrane. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals. got7fsn_ti borate membrane transport|boron transmembrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-13T09:24:23Z biological_process owl:Class
GO:0001917 biolink:NamedThing photoreceptor inner segment The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs. got7fsn_ti cellular_component owl:Class
GO:0072250 biolink:NamedThing metanephric glomerular visceral epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros. got7fsn_ti metanephric podocyte cell fate commitment mah 2010-03-19T03:46:41Z biological_process owl:Class
GO:0019634 biolink:NamedThing organic phosphonate metabolic process The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. got7fsn_ti organophosphonate metabolic process|phosphonate metabolism biological_process owl:Class
GO:0050775 biolink:NamedThing positive regulation of dendrite morphogenesis Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis. got7fsn_ti up regulation of dendrite morphogenesis|stimulation of dendrite morphogenesis|upregulation of dendrite morphogenesis|up-regulation of dendrite morphogenesis|activation of dendrite morphogenesis biological_process owl:Class
GO:2000634 biolink:NamedThing regulation of primary miRNA processing Any process that modulates the frequency, rate or extent of primary microRNA processing. got7fsn_ti regulation of primary microRNA processing|regulation of pri-miRNA processing dph 2011-04-18T03:50:50Z biological_process owl:Class
GO:1901029 biolink:NamedThing negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. got7fsn_ti inhibition of MOMP|down-regulation of MOMP|down-regulation of mitochondrial outer membrane permeabilization|down regulation of MOMP|negative regulation of mitochondrial outer membrane permeabilization|down regulation of mitochondrial outer membrane permeabilization|downregulation of MOMP|downregulation of mitochondrial outer membrane permeabilization|negative regulation of MOMP|inhibition of mitochondrial outer membrane permeabilization pr 2012-06-20T09:19:39Z biological_process owl:Class
GO:0060573 biolink:NamedThing cell fate specification involved in pattern specification The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment. got7fsn_ti dph 2009-05-05T02:19:14Z biological_process owl:Class
GO:0060581 biolink:NamedThing cell fate commitment involved in pattern specification The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type. got7fsn_ti dph 2009-05-07T12:40:55Z biological_process owl:Class
GO:1902941 biolink:NamedThing regulation of voltage-gated chloride channel activity Any process that modulates the frequency, rate or extent of voltage-gated chloride channel activity. got7fsn_ti regulation of voltage-dependent chloride channel activity|regulation of voltage gated chloride channel activity als 2014-04-28T08:55:31Z biological_process owl:Class
GO:0090725 biolink:NamedThing peripheral region of growth cone The non-central region or periphery of the migrating motile tip of a growing nerve cell axon or dendrite. got7fsn_ti tb 2016-11-18T12:44:25Z cellular_component owl:Class
GO:0031314 biolink:NamedThing extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to mitochondrial inner membrane cellular_component owl:Class
GO:0006882 biolink:NamedThing cellular zinc ion homeostasis Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell. got7fsn_ti zinc homeostasis biological_process owl:Class
GO:0140040 biolink:NamedThing mitochondrial polycistronic RNA processing The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs. got7fsn_ti pg 2017-06-16T07:18:38Z biological_process owl:Class
GO:0021880 biolink:NamedThing Notch signaling pathway involved in forebrain neuron fate commitment The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. got7fsn_ti Notch signalling pathway involved in forebrain neuron fate commitment biological_process owl:Class
GO:0010389 biolink:NamedThing regulation of G2/M transition of mitotic cell cycle Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. got7fsn_ti regulation of mitotic entry biological_process owl:Class
GO:0015199 biolink:NamedThing amino-acid betaine transmembrane transporter activity Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid. got7fsn_ti glycine betaine/proline porter activity|proline/glycine/betaine:hydrogen/sodium symporter activity|betaine transmembrane transporter activity|betaine/GABA:sodium symporter activity molecular_function owl:Class
GO:0015838 biolink:NamedThing amino-acid betaine transport The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti betaine transport biological_process owl:Class
GO:0001942 biolink:NamedThing hair follicle development The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open. got7fsn_ti GO:0001943 biological_process owl:Class
GO:0043680 biolink:NamedThing filiform apparatus A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells. got7fsn_ti cellular_component owl:Class
GO:0001772 biolink:NamedThing immunological synapse An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. got7fsn_ti c-SMAC|supramolecular activation cluster Wikipedia:Immunological_synapse cellular_component owl:Class
GO:0090210 biolink:NamedThing regulation of establishment of blood-brain barrier Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain. got7fsn_ti regulation of establishment of BBB tb 2009-12-23T12:15:53Z biological_process owl:Class
GO:0016013 biolink:NamedThing syntrophin complex A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase. got7fsn_ti nitric oxide synthase-dystrophin complex, skeletal muscle cellular_component owl:Class
GO:0009877 biolink:NamedThing nodulation The formation of nitrogen-fixing root nodules on plant roots. got7fsn_ti nodule formation|nodule development|nodule morphogenesis https://github.com/geneontology/go-ontology/issues/20305 GO:0009878 biological_process owl:Class
GO:0030235 biolink:NamedThing nitric-oxide synthase regulator activity Binds to and modulates the activity of nitric oxide synthase. got7fsn_ti nitric oxide synthase regulator activity See also 'regulation of nitric-oxide synthase activity ; GO:0050999'. molecular_function owl:Class
GO:0046854 biolink:NamedThing phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. got7fsn_ti PIP biosynthesis|phosphatidylinositol phosphate biosynthesis|phosphoinositide phosphorylation|PtdInsP biosynthesis|phosphatidylinositol phosphate phosphorylation|phosphatidylinositol phosphate biosynthetic process|phosphatidylinositol phosphorylation https://github.com/geneontology/go-ontology/issues/14184 GO:0046837 biological_process owl:Class
GO:0055018 biolink:NamedThing regulation of cardiac muscle fiber development Any process that modulates the frequency, rate or extent of cardiac muscle fiber development. got7fsn_ti regulation of heart muscle fiber development|regulation of cardiac muscle fibre development biological_process owl:Class
GO:1903400 biolink:NamedThing L-arginine transmembrane transport The directed movement of L-arginine across a membrane. got7fsn_ti pr 2014-09-01T13:45:48Z biological_process owl:Class
GO:0044226 biolink:NamedThing basal pole of neuron Portion of a neuron cell soma closest to the point where the basilar dendrite emerges. got7fsn_ti jl 2009-11-13T04:32:17Z NIF_Subcellular:sao1186862860 cellular_component owl:Class
GO:1902667 biolink:NamedThing regulation of axon guidance Any process that modulates the frequency, rate or extent of axon guidance. got7fsn_ti regulation of axon pathfinding|regulation of axon growth cone guidance|regulation of axon chemotaxis hjd 2014-01-31T18:50:10Z biological_process owl:Class
GO:1902671 biolink:NamedThing left anterior basal body Any ciliary basal body that is part of a left anterior flagellum found in Giardia species (trophozoite stage). got7fsn_ti ciliary basal body of left anterior flagellum|cilial basal body of left anterior flagellum|microtubule basal body of left anterior flagellum|ciliary basal body of left anterior cilium|cilium basal body of left anterior cilium|left anterior flagellum ciliary basal body|microtubule basal body of left anterior cilium|cilial basal body of left anterior cilium|cilium basal body of left anterior flagellum Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T14:28:44Z cellular_component owl:Class
GO:0003228 biolink:NamedThing atrial cardiac muscle tissue development The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure. got7fsn_ti atrial myocardium development dph 2009-10-13T10:53:18Z biological_process owl:Class
GO:0060299 biolink:NamedThing negative regulation of sarcomere organization Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. got7fsn_ti negative regulation of sarcomere organisation biological_process owl:Class
GO:0035631 biolink:NamedThing CD40 receptor complex A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules. got7fsn_ti bf 2010-12-21T10:35:05Z cellular_component owl:Class
GO:1904977 biolink:NamedThing lymphatic endothelial cell migration The orderly movement of a lymphatic endothelial cell from one site to another in the wall of a lymphatic vessel. got7fsn_ti dgh 2016-02-18T20:49:43Z biological_process owl:Class
GO:0071074 biolink:NamedThing eukaryotic initiation factor eIF2 binding Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation. got7fsn_ti mah 2009-11-06T01:39:02Z molecular_function owl:Class
GO:0000242 biolink:NamedThing pericentriolar material A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome. got7fsn_ti cellular_component owl:Class
GO:0097555 biolink:NamedThing right anterior flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell. got7fsn_ti right anterior cilium Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T13:18:36Z cellular_component owl:Class
GO:0002795 biolink:NamedThing negative regulation of antimicrobial peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion. got7fsn_ti downregulation of antimicrobial peptide secretion|down-regulation of antimicrobial peptide secretion|inhibition of antimicrobial peptide secretion|down regulation of antimicrobial peptide secretion biological_process owl:Class
GO:0075524 biolink:NamedThing ribosomal skipping A translation process in which a specific viral peptide prevents the ribosome from covalently linking a new inserted amino acid, and lets it continue translation, thereby cleaving the nascent protein while allowing translation to continue. got7fsn_ti This term is intended to annotate gene products involved in the process of ribosomal skipping, not viral proteins produced by this translation process. jl 2011-08-03T03:19:37Z VZ:914 biological_process owl:Class
GO:0097716 biolink:NamedThing copper ion transport across blood-brain barrier The directed movement of copper (Cu) ions passing through the blood-brain barrier. got7fsn_ti copper ion transport across BBB pr 2016-08-23T14:35:54Z biological_process owl:Class
GO:0030205 biolink:NamedThing dermatan sulfate metabolic process The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues. got7fsn_ti dermatan sulphate metabolic process|chondroitin sulfate B metabolism|dermatan sulphate metabolism|dermatan sulfate metabolism|chondroitin sulfate B metabolic process biological_process owl:Class
GO:0050655 biolink:NamedThing dermatan sulfate proteoglycan metabolic process The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. got7fsn_ti dermatan sulfate proteoglycan metabolism|chondroitin sulfate B proteoglycan metabolism|dermatan sulphate proteoglycan metabolic process|dermatan sulphate proteoglycan metabolism|chondroitin sulfate B proteoglycan metabolic process biological_process owl:Class
GO:1903383 biolink:NamedThing regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway. got7fsn_ti regulation of hydrogen peroxide-induced neuron apoptosis|regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|regulation of hydrogen peroxide-induced neuronal apoptosis|regulation of neuron apoptosis in response to hydrogen peroxide|regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|regulation of H2O2-induced neuron apoptosis|regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway bf 2014-08-27T08:50:37Z biological_process owl:Class
GO:0045470 biolink:NamedThing R8 cell-mediated photoreceptor organization The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor. got7fsn_ti R8-mediated photoreceptor organisation biological_process owl:Class
GO:0051378 biolink:NamedThing serotonin binding Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. got7fsn_ti 5-hydroxytryptamine binding molecular_function owl:Class
GO:0044613 biolink:NamedThing nuclear pore central transport channel The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153. got7fsn_ti karyopherin docking complex|nuclear pore central channel|nuclear pore transport channel|nuclear pore central plug jl 2012-06-20T01:25:30Z cellular_component owl:Class
GO:1903395 biolink:NamedThing regulation of secondary cell septum biogenesis Any process that modulates the frequency, rate or extent of secondary cell septum biogenesis. got7fsn_ti di 2014-08-29T21:42:17Z biological_process owl:Class
GO:0039018 biolink:NamedThing nephrostome development The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity. got7fsn_ti bf 2010-07-02T10:08:16Z biological_process owl:Class
GO:2001191 biolink:NamedThing regulation of gamma-delta T cell activation involved in immune response Any process that modulates the frequency, rate or extent of gamma-delta T cell activation involved in immune response. got7fsn_ti regulation of gamma-delta T-cell activation during immune response|regulation of gamma-delta T lymphocyte activation during immune response|regulation of gamma-delta T-lymphocyte activation during immune response|regulation of gamma-delta T cell activation during immune response yaf 2011-11-03T04:28:38Z biological_process owl:Class
GO:0044626 biolink:NamedThing envenomation resulting in positive regulation of cell migration in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of cell migration in the bitten organism. got7fsn_ti jl 2012-07-04T05:08:21Z biological_process owl:Class
GO:0010633 biolink:NamedThing negative regulation of epithelial cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. got7fsn_ti biological_process owl:Class
GO:0004679 biolink:NamedThing AMP-activated protein kinase activity Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. got7fsn_ti SNF1A/AMP-activated protein kinase activity|AMPK activity|5'-AMP-activated protein kinase activity Reactome:R-HSA-447074|Reactome:R-HSA-6805470|Reactome:R-HSA-163691|EC:2.7.11.11|Reactome:R-HSA-200423|Reactome:R-HSA-380927|Reactome:R-HSA-1592244|Reactome:R-HSA-5673768 molecular_function owl:Class
GO:0016208 biolink:NamedThing AMP binding Binding to AMP, adenosine monophosphate. got7fsn_ti molecular_function owl:Class
GO:0086043 biolink:NamedThing bundle of His cell action potential An action potential that occurs in a bundle of His cell. got7fsn_ti bundle of His cardiac muscle cell action potential dph 2011-11-15T12:01:18Z biological_process owl:Class
GO:0099012 biolink:NamedThing neuronal dense core vesicle membrane The lipid bilayer surrounding a neuronal dense core vesicle. got7fsn_ti cellular_component owl:Class
GO:0038117 biolink:NamedThing C-C motif chemokine 19 receptor activity Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti CCL19 receptor activity bf 2012-03-22T11:59:10Z molecular_function owl:Class
GO:0035757 biolink:NamedThing chemokine (C-C motif) ligand 19 binding Binding to chemokine (C-C motif) ligand 19. got7fsn_ti CCL19 binding bf 2011-03-25T02:02:36Z molecular_function owl:Class
GO:0072334 biolink:NamedThing UDP-galactose transmembrane transport The process in which UDP-galactose is transported across a membrane. got7fsn_ti UDP-galactose transport|UDP-galactose membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-11-03T02:03:36Z GO:0015785 biological_process owl:Class
GO:0043317 biolink:NamedThing regulation of cytotoxic T cell degranulation Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation. got7fsn_ti regulation of cytotoxic T-lymphocyte degranulation|regulation of cytotoxic T-cell degranulation|regulation of cytotoxic T-cell granule exocytosis|regulation of cytotoxic T lymphocyte degranulation|regulation of cytotoxic T lymphocyte granule exocytosis|regulation of cytotoxic T cell granule exocytosis|regulation of cytotoxic T-lymphocyte granule exocytosis biological_process owl:Class
GO:0097217 biolink:NamedThing sieve area A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements. got7fsn_ti Part of a sieve element (PO:0025406). pr 2012-01-13T05:39:03Z cellular_component owl:Class
GO:0001876 biolink:NamedThing lipoarabinomannan binding Binding to lipoarabinomannan. got7fsn_ti LAM binding molecular_function owl:Class
GO:0005658 biolink:NamedThing alpha DNA polymerase:primase complex A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which are capable of catalyzing the synthesis of an RNA primer on the lagging strand of replicating DNA and the subsequent synthesis of a smal stretch of DNA. The smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. got7fsn_ti heterotetrameric polymerase alpha holoenzyme|pol-prim|primosome|DNA polymerase alpha:primase complex cellular_component owl:Class
GO:0003887 biolink:NamedThing DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. got7fsn_ti mu DNA polymerase activity|iota DNA polymerase activity|deoxyribonucleic acid duplicase activity|deoxyribonucleic duplicase activity|DNA replicase activity|DNA polymerase alpha|Klenow fragment|deoxyribonucleic polymerase I|beta DNA polymerase activity|kappa DNA polymerase activity|DNA-dependent DNA polymerase activity|DNA polymerase II|epsilon DNA polymerase activity|zeta DNA polymerase activity|DNA polymerase V activity|nu DNA polymerase activity|DNA nucleotidyltransferase (DNA-directed) activity|Tca DNA polymerase|DNA polymerase beta|DNA polymerase III|sequenase|sigma DNA polymerase activity|eta DNA polymerase activity|deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|duplicase|DNA polymerase gamma|DNA polymerase I|Taq DNA polymerase|alpha DNA polymerase activity|delta DNA polymerase activity|lambda DNA polymerase activity|Taq Pol I|theta DNA polymerase activity|gamma DNA-directed DNA polymerase activity|DNA duplicase activity GO:0003894|GO:0016451|GO:0015999|GO:0016449|GO:0003891|GO:0003893|GO:0003888|GO:0008723|GO:0003890|GO:0019984|GO:0016452|GO:0016450|GO:0003895|GO:0016448|GO:0003889|GO:0016000 Reactome:R-HSA-5358579|Reactome:R-HSA-69116|Reactome:R-HSA-5656158|Reactome:R-HSA-5655965|MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN|Reactome:R-HSA-110317|Reactome:R-HSA-174444|Reactome:R-HSA-5691001|Reactome:R-HSA-5649883|Reactome:R-HSA-5649723|Reactome:R-HSA-164505|Reactome:R-HSA-174427|Reactome:R-HSA-73932|Reactome:R-HSA-5687360|Reactome:R-HSA-110368|Reactome:R-HSA-110319|Reactome:R-HSA-110311|Reactome:R-HSA-5656148|Reactome:R-HSA-6782208|Reactome:R-HSA-6786166|EC:2.7.7.7|Reactome:R-HSA-68950|Reactome:R-HSA-164513|Reactome:R-HSA-5693593|Reactome:R-HSA-5687640|Reactome:R-HSA-111253|Reactome:R-HSA-5653840|Reactome:R-HSA-5655892 molecular_function owl:Class
GO:1903382 biolink:NamedThing negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway. got7fsn_ti inhibition of ER stress-induced neuron intrinsic apoptotic signaling pathway|down regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|down regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|down-regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|down-regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|down-regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|down regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|downregulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|downregulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|downregulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|inhibition of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|inhibition of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway bf 2014-08-27T08:45:38Z biological_process owl:Class
GO:0005912 biolink:NamedThing adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. got7fsn_ti cell-cell adherens junction GO:0005913 Wikipedia:Adherens_junction cellular_component owl:Class
GO:0010183 biolink:NamedThing pollen tube guidance The process in which the growth of pollen tube is directed towards the female gametophyte. got7fsn_ti biological_process owl:Class
GO:0033266 biolink:NamedThing ABC-type choline transporter activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of choline across a membrane. got7fsn_ti ATP-dependent choline transmembrane transporter activity|ABC-type choline transmembrane transporter activity|ATPase-coupled choline transmembrane transporter activity|choline-transporting ATPase activity molecular_function owl:Class
GO:0015871 biolink:NamedThing choline transport The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. got7fsn_ti biological_process owl:Class
GO:0048263 biolink:NamedThing determination of dorsal identity Determination of the identity of part of an organism or organ where those parts are of the type that occur in the dorsal region. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti determination of adaxial identity biological_process owl:Class
GO:0007563 biolink:NamedThing regulation of eclosion Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg. got7fsn_ti biological_process owl:Class
GO:1904832 biolink:NamedThing negative regulation of removal of superoxide radicals Any process that stops, prevents or reduces the frequency, rate or extent of removal of superoxide radicals. got7fsn_ti down-regulation of removal of superoxide radicals|down regulation of removal of O2-|down-regulation of cellular detoxification of superoxide radicals|down regulation of removal of superoxide radicals|inhibition of removal of superoxide radicals|downregulation of removal of superoxide radicals|inhibition of removal of O2-|down regulation of removal of oxygen free radicals|negative regulation of cellular detoxification of superoxide radicals|negative regulation of removal of oxygen free radicals|inhibition of removal of oxygen free radicals|down regulation of cellular detoxification of superoxide radicals|down-regulation of removal of O2-|downregulation of cellular detoxification of superoxide radicals|negative regulation of removal of O2-|downregulation of removal of O2-|inhibition of cellular detoxification of superoxide radicals|down-regulation of removal of oxygen free radicals|downregulation of removal of oxygen free radicals rph 2015-11-24T15:30:18Z biological_process owl:Class
GO:0008039 biolink:NamedThing synaptic target recognition The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses. got7fsn_ti neuronal targeting biological_process owl:Class
GO:0036477 biolink:NamedThing somatodendritic compartment The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon. got7fsn_ti bf 2014-07-24T10:06:19Z cellular_component owl:Class
GO:1904178 biolink:NamedThing negative regulation of adipose tissue development Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. got7fsn_ti negative regulation of adipogenesis|down regulation of adipogenesis|inhibition of adipogenesis|down-regulation of adipogenesis|downregulation of adipogenesis|down regulation of adipose tissue development|downregulation of adipose tissue development|down-regulation of adipose tissue development|inhibition of adipose tissue development sl 2015-04-29T20:01:07Z biological_process owl:Class
GO:0033381 biolink:NamedThing establishment of granzyme B localization to T cell secretory granule The directed movement of the protease granzyme B to a location within a secretory granule in a T cell. got7fsn_ti establishment of granzyme B localization in T cell secretory granule|T-lymphocyte secretory granule storage of granzyme B|establishment of granzyme B localization in T-cell secretory granule|establishment of granzyme B localization in T-lymphocyte secretory granule|establishment of granzyme B localisation in T cell secretory granule|establishment of granzyme B localization in T lymphocyte secretory granule biological_process owl:Class
GO:0021722 biolink:NamedThing superior olivary nucleus maturation A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. got7fsn_ti superior olive maturation biological_process owl:Class
GO:0021590 biolink:NamedThing cerebellum maturation A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. got7fsn_ti biological_process owl:Class
GO:0035168 biolink:NamedThing larval lymph gland hemocyte differentiation The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster. got7fsn_ti larval lymph gland arthropod blood cell differentiation biological_process owl:Class
GO:0031585 biolink:NamedThing regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. got7fsn_ti regulation of inositol-1,4,5-triphosphate receptor activity|regulation of IP3 receptor activity biological_process owl:Class
GO:0070360 biolink:NamedThing migration of symbiont within host by polymerization of host actin The directional movement of an organism, usually a bacterial cell, from one place to another within its host organism, by a process involving continuous polymerization of host actin at one pole of the symbiont cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:1905764 biolink:NamedThing regulation of protection from non-homologous end joining at telomere Any process that modulates the frequency, rate or extent of protection from non-homologous end joining at telomere. got7fsn_ti regulation of protection from NHEJ-mediated telomere fusion nc 2016-12-20T11:28:21Z biological_process owl:Class
GO:0019819 biolink:NamedThing P1 peroxisome A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms. got7fsn_ti peroxisome vesicle Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. cellular_component owl:Class
GO:0035034 biolink:NamedThing histone acetyltransferase regulator activity Binds to and modulates the activity of histone acetyltransferase. got7fsn_ti histone acetylase regulator activity See also the molecular function term 'histone acetyltransferase activity ; GO:0004402'. molecular_function owl:Class
GO:0035065 biolink:NamedThing regulation of histone acetylation Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein. got7fsn_ti biological_process owl:Class
GO:0048217 biolink:NamedThing pectic matrix The gel-like pectin matrix consists of the interlinked acidic and neutral pectin networks that are further cross-linked by calcium bridges. Pectins consist largely of long chains of mostly galacturonic acid units (typically 1,4 linkages and sometimes methyl esters). Three major pectic polysaccharides (homogalacturonan, rhamnogalacturonan I and rhamnogalacturonan II) are thought to occur in all primary cell walls. got7fsn_ti cellular_component owl:Class
GO:0009530 biolink:NamedThing primary cell wall A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present. got7fsn_ti cellular_component owl:Class
GO:0001174 biolink:NamedThing transcriptional start site selection at RNA polymerase II promoter Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. got7fsn_ti krc 2011-06-20T01:35:28Z biological_process owl:Class
GO:0098909 biolink:NamedThing regulation of cardiac muscle cell action potential involved in regulation of contraction Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction. got7fsn_ti tb 2011-11-10T07:45:11Z biological_process owl:Class
GO:0015143 biolink:NamedThing urate transmembrane transporter activity Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals. got7fsn_ti uric acid transmembrane transporter activity Reactome:R-HSA-5625210|Reactome:R-HSA-561253|Reactome:R-HSA-2872497 molecular_function owl:Class
GO:0015747 biolink:NamedThing urate transport The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti uric acid transport|urate transmembrane transport biological_process owl:Class
GO:0090405 biolink:NamedThing unicellular trichome branch A cell projection part that is a branch of a unicellular trichome. got7fsn_ti Unicellular trichome (PO:0025537) is a trichome(PO:0000282) that is a single plant cell (PO:0009002). For a cell that forms a branch of a multicellular trichome, see multicellular trichome branch cell (PO:0025163). tb 2011-01-10T10:30:39Z cellular_component owl:Class
GO:0110159 biolink:NamedThing regulation of mitotic spindle formation (spindle phase one) Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). got7fsn_ti kmv 2019-08-12T15:10:26Z biological_process owl:Class
GO:0032888 biolink:NamedThing regulation of mitotic spindle elongation Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle. got7fsn_ti biological_process owl:Class
GO:0005951 biolink:NamedThing carbamoyl-phosphate synthase complex A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events. got7fsn_ti arginine-specific carbamoyl phosphate synthetase complex|carbamoyl phosphate synthase complex|carbamoyl-phosphate synthase arginine-specific complex Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. cellular_component owl:Class
GO:0061296 biolink:NamedThing negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. got7fsn_ti negative regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis|negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis dph 2010-09-06T09:54:49Z biological_process owl:Class
GO:1904301 biolink:NamedThing regulation of maternal process involved in parturition Any process that modulates the frequency, rate or extent of maternal process involved in parturition. got7fsn_ti sl 2015-06-09T23:01:32Z biological_process owl:Class
GO:1990171 biolink:NamedThing SCF complex disassembly in response to cadmium stress The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress. got7fsn_ti rb 2013-08-15T22:38:06Z biological_process owl:Class
GO:1905823 biolink:NamedThing negative regulation of mitotic sister chromatid arm separation Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid arm separation. got7fsn_ti inhibition of mitotic sister chromatid arm separation|down-regulation of mitotic sister chromatid arm separation|down regulation of mitotic sister chromatid arm separation|downregulation of mitotic sister chromatid arm separation als 2017-01-16T13:36:38Z biological_process owl:Class
GO:1903186 biolink:NamedThing regulation of vitellogenesis Any process that modulates the frequency, rate or extent of vitellogenesis. got7fsn_ti regulation of yolk production mr 2014-07-14T19:28:00Z biological_process owl:Class
GO:0015170 biolink:NamedThing propanediol transmembrane transporter activity Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects. got7fsn_ti molecular_function owl:Class
GO:0015799 biolink:NamedThing propanediol transport The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects. got7fsn_ti biological_process owl:Class
GO:0034496 biolink:NamedThing multivesicular body membrane disassembly The controlled breakdown of the membranes of multivesicular bodies. got7fsn_ti MVB membrane disassembly biological_process owl:Class
GO:0036257 biolink:NamedThing multivesicular body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. got7fsn_ti MVB organization bf 2012-06-15T01:09:53Z biological_process owl:Class
GO:1901253 biolink:NamedThing negative regulation of intracellular transport of viral material Any process that stops, prevents or reduces the frequency, rate or extent of intracellular transport of viral material. got7fsn_ti inhibition of movement of virus within host cell|downregulation of egress of virus within host cell|down regulation of viral egress|inhibition of egress of virus within host cell|negative regulation of movement of virus within host cell|downregulation of viral egress|negative regulation of viral egress|down-regulation of movement of virus within host cell|downregulation of movement of virus within host cell|inhibition of viral egress|down regulation of egress of virus within host cell|down-regulation of viral egress|negative regulation of egress of virus within host cell|down-regulation of egress of virus within host cell|down regulation of movement of virus within host cell ss 2012-08-09T05:45:47Z biological_process owl:Class
GO:0005055 biolink:NamedThing laminin receptor activity Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity. got7fsn_ti Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. molecular_function owl:Class
GO:1905824 biolink:NamedThing positive regulation of mitotic sister chromatid arm separation Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid arm separation. got7fsn_ti up-regulation of mitotic sister chromatid arm separation|upregulation of mitotic sister chromatid arm separation|up regulation of mitotic sister chromatid arm separation|activation of mitotic sister chromatid arm separation als 2017-01-16T13:36:47Z biological_process owl:Class
GO:2000469 biolink:NamedThing negative regulation of peroxidase activity Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity. got7fsn_ti negative regulation of donor:hydrogen-peroxide oxidoreductase activity|negative regulation of peroxidase reaction|negative regulation of oxyperoxidase activity bf 2011-03-08T02:18:59Z biological_process owl:Class
GO:0030660 biolink:NamedThing Golgi-associated vesicle membrane The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. got7fsn_ti Golgi vesicle membrane cellular_component owl:Class
GO:0003048 biolink:NamedThing regulation of systemic arterial blood pressure by norepinephrine The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine. got7fsn_ti regulation of blood pressure by noradrenaline|blood pressure regulation by norepinephrine biological_process owl:Class
GO:1905266 biolink:NamedThing blasticidin S biosynthetic process The chemical reactions and pathways resulting in the formation of blasticidin S. got7fsn_ti blasticidin S anabolism|blasticidin S synthesis|blasticidin S formation|blasticidin S biosynthesis pr 2016-06-14T12:47:22Z biological_process owl:Class
GO:0042071 biolink:NamedThing leucokinin receptor activity Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0021899 biolink:NamedThing fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. got7fsn_ti fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment biological_process owl:Class
GO:0000148 biolink:NamedThing 1,3-beta-D-glucan synthase complex A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain. got7fsn_ti 1,3-beta-glucan synthase complex|(1->3)-beta-glucan synthase complex cellular_component owl:Class
GO:0048915 biolink:NamedThing posterior lateral line system development The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. got7fsn_ti PLL biological_process owl:Class
GO:0042663 biolink:NamedThing regulation of endodermal cell fate specification Any process that mediates the specification of a cell into an endoderm cell. got7fsn_ti regulation of endoderm cell fate specification biological_process owl:Class
GO:0015221 biolink:NamedThing lipopolysaccharide transmembrane transporter activity Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. got7fsn_ti LPS transmembrane transporter activity molecular_function owl:Class
GO:0046868 biolink:NamedThing mesosome An intracellular, often complex, membranous structure, sometimes with additional membranous lamellae inside, found in bacteria. They are associated with synthesis of DNA and secretion of proteins. got7fsn_ti Wikipedia:Mesosome cellular_component owl:Class
GO:0061789 biolink:NamedThing dense core granule priming A process that converts unprimed dense core granules (DCVs) to a pool of primed vesicles that are capable of fusing with the plasma membrane (fusion-competent) and thereby releasing their contents. Priming typically occurs after docking. got7fsn_ti large dense-core vesicle priming|LDCV priming|dense core vesicle priming dph 2016-09-08T15:41:30Z biological_process owl:Class
GO:1990504 biolink:NamedThing dense core granule exocytosis The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels. got7fsn_ti dense core vesicle exocytosis kmv 2014-09-30T21:05:50Z biological_process owl:Class
GO:0007220 biolink:NamedThing Notch receptor processing The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor. got7fsn_ti N receptor processing biological_process owl:Class
GO:0033023 biolink:NamedThing mast cell homeostasis The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus. biological_process owl:Class
GO:0044768 biolink:NamedThing NMS complex assembly The aggregation, arrangement and bonding together of a set of components to form an NMS complex. The NMS complex results from the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) and is required for kinetochore assembly. got7fsn_ti Ndc80-MIND-Spc7 complex formation|KNL-1-Mis12-Ndc80 assembly|KNL-1-Mis12-Ndc80 formation|NMS complex formation|Ndc80-MIND-Spc7 complex assembly|NMS complex assembly involved in kinetochore assembly|KMN complex interaction involved in chromosome segregation|KMN kinetochore network formation|KMN kinetochore network assembly|KMN network assembly involved in chromosome segregation|NMS complex association involved in chromosome segregation jl 2012-12-19T14:44:56Z biological_process owl:Class
GO:0006693 biolink:NamedThing prostaglandin metabolic process The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. got7fsn_ti prostaglandin metabolism biological_process owl:Class
GO:0032936 biolink:NamedThing SREBP-SCAP complex A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. got7fsn_ti Sre1-Scp1 complex cellular_component owl:Class
GO:0032775 biolink:NamedThing DNA methylation on adenine The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule. got7fsn_ti adenine methylation biological_process owl:Class
GO:0015097 biolink:NamedThing mercury ion transmembrane transporter activity Enables the transfer of mercury (Hg) ions from one side of a membrane to the other. got7fsn_ti RHEA:32815 molecular_function owl:Class
GO:0098792 biolink:NamedThing xenophagy The selective autophagy process in which a region of cytoplasm containing an intracellular pathogen or some part of an intracellular pathogen (e.g. viral capsid) is enclosed in a double membrane bound autophagosome, which then fuses with the lysosome leading to degradation of the contents. got7fsn_ti While making xenophagy a subclass of (macro)autophagy may seem to directly contradict the definition of autophagy (literally self eating), it is clear that the same pathway is involved as in macroautophagy that doesn't target foreign material: formation of double-membrane-bounded autophagosomes that enclose a region of cytoplasm for degradation. biological_process owl:Class
GO:0072544 biolink:NamedThing L-DOPA binding Binding to L-DOPA, the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid. got7fsn_ti L-dopa binding mah 2011-01-19T05:40:04Z molecular_function owl:Class
GO:1905367 biolink:NamedThing positive regulation of intralumenal vesicle formation Any process that activates or increases the frequency, rate or extent of intralumenal vesicle formation. got7fsn_ti positive regulation of endosome membrane budding|up regulation of endosome membrane budding|up-regulation of intralumenal vesicle formation|up regulation of intralumenal vesicle formation|upregulation of endosome membrane budding|up-regulation of endosome membrane budding|activation of intralumenal vesicle formation|activation of endosome membrane budding|upregulation of intralumenal vesicle formation bc 2016-08-16T12:00:16Z biological_process owl:Class
GO:0097546 biolink:NamedThing ciliary base Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. got7fsn_ti cilial base|cilium base|flagellum base|flagellar base Due to resolution issues, researchers are often unable to assign protein localization to more specific ciliary compartments such as the basal body, transition fibers or transition zone, and instead refer to 'ciliary base'. The terms GO:0036064 'ciliary basal body', GO:0097539 'ciliary transition fiber' and GO:0035869 'ciliary transition zone' represent strictly defined compartments at the ciliary base and should be used for annotation whenever possible. Also, note that cilia and eukaryotic flagella are deemed to be equivalent. pr 2013-12-17T14:16:04Z cellular_component owl:Class
GO:0032415 biolink:NamedThing regulation of sodium:proton antiporter activity Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). got7fsn_ti regulation of sodium:hydrogen antiporter activity biological_process owl:Class
GO:0014717 biolink:NamedThing regulation of satellite cell activation involved in skeletal muscle regeneration Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. got7fsn_ti biological_process owl:Class
GO:1905622 biolink:NamedThing negative regulation of leaf development Any process that stops, prevents or reduces the frequency, rate or extent of leaf development. got7fsn_ti down regulation of leaf development|down-regulation of leaf development|downregulation of leaf development|inhibition of leaf development pga 2016-10-28T15:29:57Z biological_process owl:Class
GO:0044317 biolink:NamedThing rod spherule A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body. got7fsn_ti rod photoreceptor spherule|rod cell spherule jl 2010-07-14T01:38:07Z cellular_component owl:Class
CL:0000604 biolink:NamedThing got7fsn_ti owl:Class
GO:1901212 biolink:NamedThing positive regulation of cardiac chamber formation Any process that activates or increases the frequency, rate or extent of cardiac chamber formation. got7fsn_ti up-regulation of cardiac chamber formation|upregulation of heart chamber formation|up-regulation of heart chamber formation|positive regulation of heart chamber formation|activation of cardiac chamber formation|activation of heart chamber formation|up regulation of heart chamber formation|upregulation of cardiac chamber formation|up regulation of cardiac chamber formation rl 2012-07-31T07:19:05Z biological_process owl:Class
GO:0000779 biolink:NamedThing condensed chromosome, centromeric region The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. got7fsn_ti condensed chromosome, pericentric region|condensed chromosome, centric region|condensed nuclear chromosome, centromeric region|condensed chromosome, centromere Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. GO:0000780 cellular_component owl:Class
GO:0075527 biolink:NamedThing viral RNA editing The process by which bases in viral mRNA are chemically altered during viral transcription. This is usually the incorporation of 1 - 6 additional nucleotides, which shifts the reading frame, allowing the generation of different protein products or through a specific nucleotide change that eliminates the termination codon. got7fsn_ti RNA editing involved in viral mRNA transcription jl 2011-08-04T02:07:03Z VZ:857 biological_process owl:Class
GO:0000352 biolink:NamedThing trans assembly of SL-containing precatalytic spliceosome Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA. got7fsn_ti trans assembly of spliced leader-containing precatalytic spliceosome biological_process owl:Class
GO:0098023 biolink:NamedThing virus tail, tip The basal end of the virus tail, which is used by the virus to attach to the host cell. got7fsn_ti bacteriophage tail tip bm 2012-07-19T14:13:02Z cellular_component owl:Class
GO:0030094 biolink:NamedThing plasma membrane-derived photosystem I A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species. got7fsn_ti plasma membrane photosystem I cellular_component owl:Class
GO:0099086 biolink:NamedThing synaptonemal structure A proteinaceous scaffold found between homologous chromosomes during meiosis. got7fsn_ti cellular_component owl:Class
GO:0005275 biolink:NamedThing amine transmembrane transporter activity Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. got7fsn_ti amine/amide/polyamine channel activity|amine/polyamine transmembrane transporter activity|amino acid-polyamine transmembrane transporter activity GO:0005279 molecular_function owl:Class
GO:0015837 biolink:NamedThing amine transport The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti amine/polyamine transport biological_process owl:Class
GO:0099535 biolink:NamedThing synapse-associated extracellular matrix The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. got7fsn_ti extra-synaptic extracellular matrix cellular_component owl:Class
GO:0039691 biolink:NamedThing double stranded viral RNA replication A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA. got7fsn_ti bf 2013-10-17T15:52:19Z VZ:1936 biological_process owl:Class
GO:0043504 biolink:NamedThing mitochondrial DNA repair The process of restoring mitochondrial DNA after damage. got7fsn_ti biological_process owl:Class
GO:0001228 biolink:NamedThing DNA-binding transcription activator activity, RNA polymerase II-specific A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. got7fsn_ti transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding|RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding|metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription|transcriptional activator activity, metal ion regulated sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription|metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding|sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription|proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding|distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific https://github.com/geneontology/go-ontology/issues/16534|https://github.com/geneontology/go-ontology/issues/16152|https://github.com/geneontology/go-ontology/issues/16131|https://github.com/geneontology/go-ontology/issues/20253 For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. krc 2012-01-26T03:10:20Z GO:0001211|GO:0001213|GO:0001212|GO:0001077|GO:0001209|GO:0001205 molecular_function owl:Class
GO:0046787 biolink:NamedThing viral DNA repair The process of restoring viral DNA after damage or errors in replication. got7fsn_ti biological_process owl:Class
GO:0043311 biolink:NamedThing positive regulation of eosinophil degranulation Any process that activates or increases the frequency, rate or extent of eosinophil degranulation. got7fsn_ti positive regulation of eosinophil granule exocytosis|stimulation of eosinophil degranulation|up-regulation of eosinophil degranulation|up regulation of eosinophil degranulation|upregulation of eosinophil degranulation|activation of eosinophil degranulation biological_process owl:Class
GO:0051973 biolink:NamedThing positive regulation of telomerase activity Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). got7fsn_ti activation of telomerase activity|upregulation of telomerase activity|stimulation of telomerase activity|telomerase activator|up regulation of telomerase activity|up-regulation of telomerase activity biological_process owl:Class
GO:1901214 biolink:NamedThing regulation of neuron death Any process that modulates the frequency, rate or extent of neuron death. got7fsn_ti regulation of neuron cell death|regulation of neuronal cell death rph 2012-08-02T09:57:41Z biological_process owl:Class
GO:0140663 biolink:NamedThing ATP-dependent FeS chaperone activity Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21661 pg 2021-06-19T16:33:09Z molecular_function owl:Class
GO:0072258 biolink:NamedThing metanephric interstitial fibroblast differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the interstitial fibroblasts of the metanephros as it progresses from its formation to the mature state. got7fsn_ti metanephros interstitial cell differentiation mah 2010-03-19T04:17:32Z biological_process owl:Class
GO:0043539 biolink:NamedThing protein serine/threonine kinase activator activity Binds to and increases the activity of a protein serine/threonine kinase. got7fsn_ti protein ser/thr kinase activator activity molecular_function owl:Class
GO:0071902 biolink:NamedThing positive regulation of protein serine/threonine kinase activity Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity. got7fsn_ti mah 2010-09-15T03:09:57Z biological_process owl:Class
GO:0008377 biolink:NamedThing light-induced release of internally sequestered calcium ion The process in which the detection of light triggers the release of internally sequestered calcium ions. got7fsn_ti light-induced release of internally stored calcium ion (Ca2+)|light-induced release of calcium from internal store|light-induced release of internally sequestered calcium ion (Ca2+) biological_process owl:Class
GO:0016056 biolink:NamedThing rhodopsin mediated signaling pathway The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response. got7fsn_ti rhodopsin mediated phototransduction|rhodopsin mediated signalling pathway|rhodopsin signaling GO:0009586 biological_process owl:Class
GO:0031360 biolink:NamedThing intrinsic component of thylakoid membrane The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to thylakoid membrane cellular_component owl:Class
GO:1905617 biolink:NamedThing negative regulation of miRNA mediated inhibition of translation Any process that stops, prevents or reduces the frequency, rate or extent of miRNA mediated inhibition of translation. got7fsn_ti down-regulation of negative regulation of translation involved in gene silencing by microRNA|down-regulation of miRNA mediated inhibition of translation|down regulation of negative regulation of translation involved in gene silencing by microRNA|down regulation of miRNA-mediated gene silencing, negative regulation of translation|inhibition of gene silencing by miRNA, negative regulation of translation|down-regulation of miRNA-mediated gene silencing, negative regulation of translation|down regulation of down-regulation of translation involved in gene silencing by miRNA|inhibition of inhibition of translation involved in gene silencing by miRNA|inhibition of negative regulation of translation involved in gene silencing by microRNA|negative regulation of down-regulation of translation involved in gene silencing by miRNA|inhibition of downregulation of translation involved in gene silencing by miRNA|inhibition of down-regulation of translation involved in gene silencing by miRNA|negative regulation of miRNA-mediated gene silencing, negative regulation of translation|downregulation of miRNA-mediated gene silencing, negative regulation of translation|down-regulation of gene silencing by miRNA, negative regulation of translation|inhibition of miRNA-mediated gene silencing, negative regulation of translation|negative regulation of inhibition of translation involved in gene silencing by miRNA|downregulation of down-regulation of translation involved in gene silencing by miRNA|down regulation of miRNA mediated inhibition of translation|downregulation of gene silencing by miRNA, negative regulation of translation|down regulation of down regulation of translation involved in gene silencing by miRNA|downregulation of negative regulation of translation involved in gene silencing by microRNA|inhibition of down regulation of translation involved in gene silencing by miRNA|down-regulation of down regulation of translation involved in gene silencing by miRNA|downregulation of inhibition of translation involved in gene silencing by miRNA|down-regulation of down-regulation of translation involved in gene silencing by miRNA|down regulation of downregulation of translation involved in gene silencing by miRNA|negative regulation of negative regulation of translation involved in gene silencing by microRNA|down-regulation of inhibition of translation involved in gene silencing by miRNA|downregulation of miRNA mediated inhibition of translation|negative regulation of downregulation of translation involved in gene silencing by miRNA|downregulation of downregulation of translation involved in gene silencing by miRNA|inhibition of miRNA mediated inhibition of translation|down regulation of inhibition of translation involved in gene silencing by miRNA|negative regulation of gene silencing by miRNA, negative regulation of translation|down-regulation of downregulation of translation involved in gene silencing by miRNA|negative regulation of down regulation of translation involved in gene silencing by miRNA|down regulation of gene silencing by miRNA, negative regulation of translation|downregulation of down regulation of translation involved in gene silencing by miRNA bc 2016-10-28T11:47:57Z biological_process owl:Class
GO:0005365 biolink:NamedThing myo-inositol transmembrane transporter activity Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. got7fsn_ti vitamin Bh transporter activity molecular_function owl:Class
GO:0015798 biolink:NamedThing myo-inositol transport The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms. got7fsn_ti vitamin Bh transport biological_process owl:Class
GO:0003167 biolink:NamedThing atrioventricular bundle cell differentiation The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers. got7fsn_ti AV bundle cell differentiation dph 2009-10-01T02:48:23Z biological_process owl:Class
GO:0003166 biolink:NamedThing bundle of His development The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers. got7fsn_ti atrioventricular bundle development dph 2009-10-01T02:08:43Z biological_process owl:Class
GO:2001190 biolink:NamedThing positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Any process that activates or increases the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. got7fsn_ti positive regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|positive regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|positive regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell yaf 2011-11-03T01:31:40Z biological_process owl:Class
GO:0045506 biolink:NamedThing interleukin-24 receptor activity Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-24R|IL-24 receptor activity molecular_function owl:Class
GO:0045510 biolink:NamedThing interleukin-24 binding Binding to interleukin-24. got7fsn_ti IL-24 binding molecular_function owl:Class
GO:0004536 biolink:NamedThing deoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. got7fsn_ti caspase-activated deoxyribonuclease activity GO:0004537 Reactome:R-HSA-5685994|Reactome:R-HSA-211247|Reactome:R-HSA-6785986 molecular_function owl:Class
GO:1990222 biolink:NamedThing ProVWX complex The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions. got7fsn_ti ATP-binding cassette (ABC) transporter complex ProVWX bhm 2013-10-16T09:09:17Z cellular_component owl:Class
GO:1904413 biolink:NamedThing negative regulation of cardiac ventricle development Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development. got7fsn_ti downregulation of cardiac ventricle development|inhibition of cardiac ventricle development|down-regulation of cardiac ventricle development|down regulation of cardiac ventricle development sl 2015-06-25T19:52:21Z biological_process owl:Class
GO:0033335 biolink:NamedThing anal fin development The process whose specific outcome is the progression of the anal fin over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0034992 biolink:NamedThing microtubule organizing center attachment site A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope. got7fsn_ti MAS|microtubule organising centre attachment site|MTOC attachment site Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. cellular_component owl:Class
GO:0005228 biolink:NamedThing intracellular sodium activated potassium channel activity Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification. got7fsn_ti molecular_function owl:Class
CHEBI:29103 biolink:NamedThing got7fsn_ti owl:Class
GO:1902938 biolink:NamedThing regulation of intracellular calcium activated chloride channel activity Any process that modulates the frequency, rate or extent of intracellular calcium activated chloride channel activity. got7fsn_ti als 2014-04-28T08:49:08Z biological_process owl:Class
GO:0060338 biolink:NamedThing regulation of type I interferon-mediated signaling pathway Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. got7fsn_ti regulation of type I interferon-mediated signalling pathway biological_process owl:Class
GO:0001650 biolink:NamedThing fibrillar center A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. got7fsn_ti fibrillar centre cellular_component owl:Class
GO:0005836 biolink:NamedThing fatty-acyl-CoA synthase complex A protein complex that possesses fatty-acyl-CoA synthase activity. got7fsn_ti fatty acyl CoA synthase complex Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes. cellular_component owl:Class
GO:0019801 biolink:NamedThing cyclization of asparagine involved in intein-mediated protein splicing The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing. got7fsn_ti cyclization of asparagine, during protein splicing See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. RESID:AA0302 biological_process owl:Class
GO:0016539 biolink:NamedThing intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. got7fsn_ti intein biological_process owl:Class
GO:0046964 biolink:NamedThing 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity Enables the transfer of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride synthesized from adenosine 5'-phosphosulfate, from one side of a membrane to the other. got7fsn_ti 3'-phosphoadenosine 5'-phosphosulphate transporter activity|PAPS transporter activity|adenosine 3'-phosphate 5'-phosphosulfate transmembrane transporter activity Reactome:R-HSA-741449 molecular_function owl:Class
GO:1902559 biolink:NamedThing 3'-phospho-5'-adenylyl sulfate transmembrane transport The process in which 3'-phospho-5'-adenylyl sulfate is transported across a membrane. got7fsn_ti 3'-phosphoadenosine 5'-phosphosulfate transmembrane transport mcc 2013-12-09T23:19:04Z biological_process owl:Class
GO:0030915 biolink:NamedThing Smc5-Smc6 complex A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans. got7fsn_ti cellular_component owl:Class
GO:0000793 biolink:NamedThing condensed chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure. got7fsn_ti cytoplasmic mitotic chromosome|metaphase chromosome|mitotic chromosome Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. cellular_component owl:Class
GO:0005672 biolink:NamedThing transcription factor TFIIA complex A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). got7fsn_ti cellular_component owl:Class
GO:1990731 biolink:NamedThing UV-damage excision repair, DNA incision A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs). got7fsn_ti UV-damaged DNA endonuclease-dependent excision repair, DNA incision|DNA incision involved in UVER|nucleic acid cleavage involved in UV-damage excision repair|UVDE-dependent excision repair, DNA incision|DNA incision involved in alternative excision repair|DNA incision involved in UV-damaged DNA endonuclease-dependent excision repair|DNA incision involved in UV-damage excision repair|DNA incision involved in UVDE-dependent excision repair|DNA incision involved in AER|alternative excision repair, DNA incision mah 2015-04-21T15:09:04Z biological_process owl:Class
GO:0110028 biolink:NamedThing positive regulation of mitotic spindle organization Any process that activates or increases the frequency, rate or extent of mitotic spindle organization. got7fsn_ti kmv 2017-07-06T14:14:08Z biological_process owl:Class
GO:0000080 biolink:NamedThing mitotic G1 phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis. got7fsn_ti G1 phase of mitotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0097197 biolink:NamedThing tetraspanin-enriched microdomain A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities. got7fsn_ti TEM|membrane tetraspanin-enriched microdomain pr 2011-12-02T04:21:37Z cellular_component owl:Class
GO:0030988 biolink:NamedThing high molecular weight kininogen receptor complex A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins. got7fsn_ti cellular_component owl:Class
GO:0000964 biolink:NamedThing mitochondrial RNA 5'-end processing Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion. got7fsn_ti mitochondrial RNA 5' end processing biological_process owl:Class
GO:0033614 biolink:NamedThing chloroplast proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane. got7fsn_ti biological_process owl:Class
GO:0007358 biolink:NamedThing establishment of central gap gene boundaries Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel. got7fsn_ti biological_process owl:Class
GO:0097105 biolink:NamedThing presynaptic membrane assembly The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. got7fsn_ti pre-synaptic membrane assembly Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron. pr 2011-07-27T01:30:45Z biological_process owl:Class
GO:0001549 biolink:NamedThing cumulus cell differentiation The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell. got7fsn_ti ovarian cumulus cell differentiation biological_process owl:Class
GO:0019960 biolink:NamedThing C-X3-C chemokine binding Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif. got7fsn_ti molecular_function owl:Class
GO:0048093 biolink:NamedThing positive regulation of male pigmentation Any process that activates or increases the frequency, rate or extent of establishment of a pattern of pigment in males. got7fsn_ti upregulation of male pigmentation|activation of male pigmentation|up-regulation of male pigmentation|up regulation of male pigmentation|stimulation of male pigmentation biological_process owl:Class
GO:0099546 biolink:NamedThing protein catabolic process, modulating synaptic transmission Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0080161 biolink:NamedThing auxin transmembrane transporter activity Enables the transfer of auxins from one side of a membrane to the other. Auxins are plant hormones that regulate aspects of plant growth. got7fsn_ti dhl 2010-09-23T03:37:43Z molecular_function owl:Class
GO:0031080 biolink:NamedThing nuclear pore outer ring A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates). got7fsn_ti Nup84 complex|Nup107-160 complex|Nup107-120 complex cellular_component owl:Class
GO:0140442 biolink:NamedThing peroxide sensor activity Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19126 pg 2020-03-24T09:09:43Z molecular_function owl:Class
CHEBI:14321 biolink:NamedThing got7fsn_ti owl:Class
GO:0106160 biolink:NamedThing negative regulation of small RNA loading onto RISC Any process that stops, prevents or reduces the frequency, rate or extent of small RNA loading onto RISC. got7fsn_ti hjd 2018-11-30T15:42:16Z biological_process owl:Class
GO:0086059 biolink:NamedThing voltage-gated calcium channel activity involved SA node cell action potential Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated calcium channel activity involved in SA node cardiac muscle cell action potential|voltage-gated calcium channel activity involved in sinus node cardiac muscle cell action potential|voltage-gated calcium channel activity involved in SAN cardiac muscle cell action potential|voltage-gated calcium channel activity involved in sinoatrial node cardiac muscle cell action potential dph 2011-11-17T12:39:27Z molecular_function owl:Class
GO:0062075 biolink:NamedThing pollen aperture formation The cellular component assembly process of forming pollen apertures, areas where exine is reduced or absent, in the pollen cell wall. got7fsn_ti dph 2018-09-19T19:25:59Z biological_process owl:Class
GO:0019164 biolink:NamedThing pyruvate synthase activity Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. got7fsn_ti PFOR|pyruvate:ferredoxin oxidoreductase activity|pyruvate-ferredoxin reductase activity|pyruvate oxidoreductase activity|pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)|pyruvate synthetase activity|pyruvic-ferredoxin oxidoreductase activity GO:0018696 RHEA:12765|MetaCyc:PYRUFLAVREDUCT-RXN|EC:1.2.7.1|KEGG_REACTION:R01196 molecular_function owl:Class
GO:0006086 biolink:NamedThing acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate. got7fsn_ti acetyl-CoA synthesis from pyruvate|acetyl-CoA anabolism from pyruvate|pyruvate dehydrogenase pathway|acetyl-CoA formation from pyruvate MetaCyc:PYRUVDEHYD-PWY biological_process owl:Class
GO:0004170 biolink:NamedThing dUTP diphosphatase activity Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. got7fsn_ti desoxyuridine 5'-triphosphate nucleotidohydrolase activity|dUTP nucleotidohydrolase activity|deoxyuridine-triphosphatase activity|desoxyuridine 5'-triphosphatase activity|dUTPase activity|dUTP pyrophosphatase activity MetaCyc:DUTP-PYROP-RXN|RHEA:10248|EC:3.6.1.23|KEGG_REACTION:R02100|Reactome:R-HSA-73666 molecular_function owl:Class
GO:0015129 biolink:NamedThing lactate transmembrane transporter activity Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. got7fsn_ti monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity Reactome:R-HSA-373875|Reactome:R-HSA-373867 molecular_function owl:Class
GO:0035873 biolink:NamedThing lactate transmembrane transport The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. got7fsn_ti lactate membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2011-05-31T09:26:59Z biological_process owl:Class
GO:2001271 biolink:NamedThing negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in execution phase of apoptosis. got7fsn_ti negative regulation of effector caspase activity pr 2011-12-13T07:59:42Z biological_process owl:Class
GO:0070132 biolink:NamedThing regulation of mitochondrial translational initiation Any process that modulates the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. got7fsn_ti regulation of mitochondrial translation initiation biological_process owl:Class
GO:0051387 biolink:NamedThing negative regulation of neurotrophin TRK receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the neurotrophin TRK receptor signaling pathway. got7fsn_ti down-regulation of nerve growth factor receptor signaling pathway|down regulation of nerve growth factor receptor signaling pathway|inhibition of nerve growth factor receptor signaling pathway|negative regulation of NGF receptor signaling pathway|negative regulation of nerve growth factor receptor signaling pathway|negative regulation of NGF receptor signalling pathway|negative regulation of nerve growth factor receptor signalling pathway|downregulation of nerve growth factor receptor signaling pathway biological_process owl:Class
GO:0072272 biolink:NamedThing proximal/distal pattern formation involved in metanephric nephron development The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis of a nephron in the metanephros. The proximal/distal axis is defined by a line that runs from the center of the kidney (proximal end) outward (distal end). got7fsn_ti proximal/distal metanephric nephron patterning|proximal-distal pattern formation involved in metanephric nephron development mah 2010-03-30T03:25:37Z biological_process owl:Class
GO:2000621 biolink:NamedThing regulation of DNA replication termination Any process that modulates the frequency, rate or extent of DNA replication termination. got7fsn_ti pr 2011-04-18T03:26:23Z biological_process owl:Class
GO:1990900 biolink:NamedThing ciliary pocket collar A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma. got7fsn_ti FPC|flagellar collar|cilium pocket collar|flagellum pocket collar|flagellar pore|flagellar pocket collar Note that a 'flagellar collar' is described in Choanoflagellates, but this is different from the ciliary pocket collar found e.g. in Giardia; in Choanoflagellates, a single apical flagellum is surrounded by a collar of 30-40 microvilli. pr 2015-11-17T14:43:55Z cellular_component owl:Class
GO:1905139 biolink:NamedThing apical ectodermal ridge formation The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti AER formation|apical epidermal ridge formation|crista ectodermalis apicalis formation dph 2016-04-13T11:46:40Z biological_process owl:Class
GO:0042890 biolink:NamedThing 3-phenylpropionic acid transmembrane transporter activity Enables the transfer of 3-phenylpropionic acid from one side of a membrane to the other. got7fsn_ti hydrocinnamic acid transporter activity|3-phenylpropionate acid transporter activity|HCA transporter activity molecular_function owl:Class
GO:0042889 biolink:NamedThing 3-phenylpropionic acid transport The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti 3-phenylpropionate transport|hydrocinnamic acid transport|HCA transport biological_process owl:Class
GO:0017089 biolink:NamedThing glycolipid transfer activity Removes a glycolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. A glycolipid is a compound usually containing 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid. got7fsn_ti intermembrane glycolipid transfer activity|glycolipid carrier activity|intermembrane glycolipid transporter activity|glycolipid transporter activity Reactome:R-HSA-9697077|Reactome:R-HSA-5340320 molecular_function owl:Class
GO:0046836 biolink:NamedThing glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0098895 biolink:NamedThing postsynaptic endosome membrane The lipid bilayer surrounding a postsynaptic endosome. got7fsn_ti cellular_component owl:Class
GO:0098845 biolink:NamedThing postsynaptic endosome An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse. got7fsn_ti cellular_component owl:Class
GO:0042412 biolink:NamedThing taurine biosynthetic process The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats. got7fsn_ti taurine formation|taurine anabolism|taurine biosynthesis|taurine synthesis biological_process owl:Class
GO:0015499 biolink:NamedThing formate transmembrane transporter activity Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid. got7fsn_ti formate uptake permease activity|formate uptake transmembrane transporter activity GO:0015659 RHEA:29679 molecular_function owl:Class
GO:0015724 biolink:NamedThing formate transport The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0046626 biolink:NamedThing regulation of insulin receptor signaling pathway Any process that modulates the frequency, rate or extent of insulin receptor signaling. got7fsn_ti regulation of insulin receptor signalling pathway biological_process owl:Class
GO:0010457 biolink:NamedThing centriole-centriole cohesion The cell cycle process in which the two centrioles within a centrosome remain tightly paired. got7fsn_ti biological_process owl:Class
GO:0045630 biolink:NamedThing positive regulation of T-helper 2 cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper 2 cell differentiation. got7fsn_ti activation of T-helper 2 cell differentiation|stimulation of T-helper 2 cell differentiation|up-regulation of T-helper 2 cell differentiation|upregulation of T-helper 2 cell differentiation|up regulation of T-helper 2 cell differentiation|positive regulation of T-helper 2 cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0072540 biolink:NamedThing T-helper 17 cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17. got7fsn_ti Th17 fate commitment|Th17 cell lineage commitment|T-helper 17 cell fate commitment mah 2011-01-17T11:19:48Z biological_process owl:Class
GO:0035193 biolink:NamedThing larval central nervous system remodeling Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster. got7fsn_ti CNS metamorphosis|central nervous system metamorphosis biological_process owl:Class
GO:0042047 biolink:NamedThing W-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands. got7fsn_ti W-molybdopterin cofactor biosynthesis|W-molybdopterin cofactor synthesis|W-molybdopterin cofactor formation|Moco biosynthesis|Moco biosynthetic process|W-molybdopterin cofactor anabolism biological_process owl:Class
GO:1902917 biolink:NamedThing positive regulation of mating projection assembly Any process that activates or increases the frequency, rate or extent of mating projection assembly. got7fsn_ti positive regulation of mating projection biogenesis|upregulation of mating projection biogenesis|up regulation of mating projection biogenesis|activation of mating projection assembly|up regulation of mating projection assembly|upregulation of mating projection assembly|up-regulation of mating projection assembly|up-regulation of mating projection biogenesis|activation of mating projection biogenesis di 2014-04-20T11:18:03Z biological_process owl:Class
GO:0031139 biolink:NamedThing positive regulation of conjugation with cellular fusion Any process that increases the rate or frequency of conjugation with cellular fusion. got7fsn_ti up-regulation of conjugation with cellular fusion|stimulation of conjugation with cellular fusion|up regulation of conjugation with cellular fusion|upregulation of conjugation with cellular fusion|activation of conjugation with cellular fusion biological_process owl:Class
OBO:OPL_0000114 biolink:NamedThing got7fsn_ti owl:Class
GO:0060212 biolink:NamedThing negative regulation of nuclear-transcribed mRNA poly(A) tail shortening Any process that decreases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length. got7fsn_ti negative regulation of 3' to 5' mRNA deadenylation|negative regulation of mRNA deadenylation|negative regulation of nuclear mRNA poly(A) tail shortening biological_process owl:Class
GO:0002798 biolink:NamedThing negative regulation of antibacterial peptide secretion Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion. got7fsn_ti inhibition of antibacterial peptide secretion|down-regulation of antibacterial peptide secretion|downregulation of antibacterial peptide secretion|down regulation of antibacterial peptide secretion biological_process owl:Class
GO:1903060 biolink:NamedThing negative regulation of protein lipidation Any process that stops, prevents or reduces the frequency, rate or extent of protein lipidation. got7fsn_ti down-regulation of protein lipidation|inhibition of protein lipidation|negative regulation of protein amino acid lipidation|downregulation of protein lipidation|down-regulation of protein amino acid lipidation|downregulation of protein amino acid lipidation|downregulation of lipid:protein modification|inhibition of lipid:protein modification|down regulation of lipid:protein modification|down regulation of protein lipidation|down-regulation of lipid:protein modification|inhibition of protein amino acid lipidation|negative regulation of lipid:protein modification|down regulation of protein amino acid lipidation rph 2014-05-28T13:21:25Z biological_process owl:Class
GO:0021620 biolink:NamedThing hypoglossal nerve formation The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue. got7fsn_ti CN XII biosynthesis|CN XII formation biological_process owl:Class
GO:0106055 biolink:NamedThing mannosyl-oligosaccharide 1,2-alpha-mannosidase complex A protein complex capable of catalysing the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. got7fsn_ti An example is MNL1 (P38888) in Saccharomyces cerevisiae. PMID:19124653 (by physical interaction evidence). hjd 2017-09-14T15:23:28Z cellular_component owl:Class
GO:0021523 biolink:NamedThing somatic motor neuron differentiation The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0048053 biolink:NamedThing R1/R6 development The process whose specific outcome is the progression of the R1 and R6 pair of photoreceptors in the eye over time, from their formation to the mature structures. R1 and R6 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0090637 biolink:NamedThing inner dense plaque of desmosome The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane. got7fsn_ti tb 2015-04-20T16:10:51Z cellular_component owl:Class
GO:0007499 biolink:NamedThing ectoderm and mesoderm interaction A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm. got7fsn_ti ectoderm/mesoderm interaction biological_process owl:Class
UBERON:0003053 biolink:NamedThing got7fsn_ti owl:Class
GO:0005324 biolink:NamedThing long-chain fatty acid transporter activity Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. got7fsn_ti GO:0005325|GO:0008562 Reactome:R-HSA-5684043|Reactome:R-HSA-434381|Reactome:R-HSA-2046087|Reactome:R-HSA-382575|Reactome:R-HSA-390393|Reactome:R-HSA-2046093 molecular_function owl:Class
GO:0035859 biolink:NamedThing Seh1-associated complex A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p. got7fsn_ti SEA complex|GATOR complex https://github.com/geneontology/go-ontology/issues/21778 The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131. bf 2011-05-17T10:59:50Z cellular_component owl:Class
GO:1903294 biolink:NamedThing regulation of glutamate secretion, neurotransmission Any process that modulates the frequency, rate or extent of glutamate secretion, neurotransmission. got7fsn_ti An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype pad 2014-08-13T13:54:15Z biological_process owl:Class
GO:0042009 biolink:NamedThing interleukin-15 binding Binding to interleukin-15. got7fsn_ti IL-15 binding molecular_function owl:Class
GO:0097231 biolink:NamedThing cell motility in response to calcium ion Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus. got7fsn_ti calcium ion facilitation of cell motility|Ca2+ facilitation of cell motility pr 2012-01-25T04:42:45Z biological_process owl:Class
GO:1904113 biolink:NamedThing negative regulation of muscle filament sliding Any process that stops, prevents or reduces the frequency, rate or extent of muscle filament sliding. got7fsn_ti down regulation of muscle filament sliding|inhibition of muscle filament sliding|downregulation of muscle filament sliding|down-regulation of muscle filament sliding kmv 2015-04-03T18:40:38Z biological_process owl:Class
GO:0033600 biolink:NamedThing negative regulation of mammary gland epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of mammary gland epithelial cell proliferation. got7fsn_ti down-regulation of mammary gland epithelial cell proliferation|inhibition of mammary gland epithelial cell proliferation|downregulation of mammary gland epithelial cell proliferation|down regulation of mammary gland epithelial cell proliferation biological_process owl:Class
GO:1901193 biolink:NamedThing regulation of formation of translation preinitiation complex Any process that modulates the frequency, rate or extent of formation of translation preinitiation complex. got7fsn_ti regulation of translation preinitiation complex assembly|regulation of formation of translation pre-initiation complex ss 2012-07-25T02:31:20Z biological_process owl:Class
GO:0090417 biolink:NamedThing N-methylnicotinate transmembrane transporter activity Enables the transfer of N-methylnicotinate from one side of a membrane to the other. got7fsn_ti N-methylnicotinate transporter activity tb 2011-10-19T11:09:59Z molecular_function owl:Class
GO:2001143 biolink:NamedThing N-methylnicotinate transport The directed movement of a N-methylnicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti tb 2011-10-18T05:16:08Z biological_process owl:Class
GO:0008363 biolink:NamedThing larval chitin-based cuticle development Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster. got7fsn_ti larval cuticle anabolism|larval cuticle synthesis|larval cuticle biosynthetic process|larval cuticle formation biological_process owl:Class
GO:1990589 biolink:NamedThing ATF4-CREB1 transcription factor complex Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway. got7fsn_ti bhm 2014-12-15T14:22:44Z cellular_component owl:Class
GO:1903762 biolink:NamedThing positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization. got7fsn_ti up regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|up regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|upregulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|positive regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|upregulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|positive regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|activation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|activation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|positive regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|up regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|up regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|up-regulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|upregulation of voltage gated potassium channel activity involved in ventricular cardiac muscle cell action potential|up-regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|up-regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|up-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|activation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|up regulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|upregulation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|activation of voltage-gated potassium ion channel activity involved in ventricular cardiac muscle cell action potential|activation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential|upregulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|up-regulation of voltage-dependent potassium channel activity involved in ventricular cardiac muscle cell action potential|positive regulation of voltage-sensitive potassium channel involved in ventricular cardiac muscle cell action potential rl 2014-12-19T12:02:18Z biological_process owl:Class
GO:0032074 biolink:NamedThing negative regulation of nuclease activity Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids. got7fsn_ti down-regulation of nuclease activity|downregulation of nuclease activity|inhibition of nuclease activity|down regulation of nuclease activity|nuclease inhibitor biological_process owl:Class
GO:1990207 biolink:NamedThing EmrE multidrug transporter complex A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer. got7fsn_ti EmrE complex bhm 2013-10-08T08:37:52Z cellular_component owl:Class
GO:0044718 biolink:NamedThing siderophore transmembrane transport The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore. got7fsn_ti siderophore membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. jl 2012-10-18T13:43:56Z biological_process owl:Class
GO:1903689 biolink:NamedThing regulation of wound healing, spreading of epidermal cells Any process that modulates the frequency, rate or extent of wound healing, spreading of epidermal cells. got7fsn_ti als 2014-12-01T15:54:18Z biological_process owl:Class
GO:0061147 biolink:NamedThing endocardial endothelium development The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. got7fsn_ti dph 2010-06-03T09:15:31Z biological_process owl:Class
GO:0003290 biolink:NamedThing atrial septum secundum morphogenesis The process in which anatomical structure of an atrial septum secundum is generated and organized. got7fsn_ti dph 2009-10-20T10:33:57Z biological_process owl:Class
GO:0033362 biolink:NamedThing lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate; in this pathway tetrahydrodipicolinate is converted to meso-diaminopimelate in two enzymatic steps. got7fsn_ti lysine synthesis via diaminopimelate, diaminopimelate-aminotransferase pathway|lysine anabolism via diaminopimelate, diaminopimelate-aminotransferase pathway|lysine biosynthesis via diaminopimelate, diaminopimelate-aminotransferase pathway|lysine formation via diaminopimelate, diaminopimelate-aminotransferase pathway MetaCyc:PWY-5097 biological_process owl:Class
GO:0004704 biolink:NamedThing NF-kappaB-inducing kinase activity Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK). got7fsn_ti NIK molecular_function owl:Class
GO:0061452 biolink:NamedThing retrotrapezoid nucleus neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus. got7fsn_ti dph 2012-07-19T12:43:18Z biological_process owl:Class
GO:2000731 biolink:NamedThing negative regulation of termination of RNA polymerase I transcription Any process that stops, prevents or reduces the frequency, rate or extent of termination of RNA polymerase I transcription. got7fsn_ti negative regulation of transcription termination from RNA polymerase I promoter|negative regulation of transcription termination from Pol I promoter|negative regulation of RNA polymerase I transcription termination dph 2011-06-10T08:43:44Z biological_process owl:Class
GO:0072004 biolink:NamedThing kidney field specification The process that results in the delineation of regions of the embryo into the area in which the kidney rudiment will develop. got7fsn_ti specification of kidney anlage mah 2010-01-25T11:24:33Z biological_process owl:Class
GO:0051486 biolink:NamedThing isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate pathway that contributes to terpenoid biosynthesis. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates. got7fsn_ti isopentenyl diphosphate formation, mevalonate pathway, during terpenoid biosynthesis|isopentenyl diphosphate synthesis, mevalonate pathway, during terpenoid synthesis|isopentenyl diphosphate biosynthetic process, mevalonate pathway, during terpenoid biosynthetic process|isopentenyl diphosphate anabolism, mevalonate pathway, during terpenoid anabolism|isopentenyl diphosphate formation, mevalonate pathway, during terpenoid formation biological_process owl:Class
GO:0051485 biolink:NamedThing terpenoid biosynthetic process, mevalonate-dependent The chemical reactions and pathways resulting in the formation of terpenoids via isopentenyl diphosphate, synthesized by the mevalonate pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-dependent terpenoid biosynthesis, acetate, in the form of acetyl-CoA, is converted to isopentenyl diphosphate (IPP) through a series of mevalonate intermediates. got7fsn_ti terpenoid synthesis, mevalonate-dependent|terpene biosynthetic process, mevalonate-dependent|terpenoid formation, mevalonate-dependent|terpene biosynthesis, mevalonate-dependent|terpenoid anabolism, mevalonate-dependent biological_process owl:Class
GO:0060289 biolink:NamedThing compartment boundary maintenance A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier. got7fsn_ti biological_process owl:Class
GO:0060574 biolink:NamedThing intestinal epithelial cell maturation The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus. got7fsn_ti dph 2009-05-06T08:10:41Z biological_process owl:Class
GO:0042800 biolink:NamedThing histone methyltransferase activity (H3-K4 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein. got7fsn_ti histone lysine N-methyltransferase activity (H3-K4 specific)|histone H3 lysine 4-specific methyltransferase activity|histone methylase activity (H3-K4 specific) Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies. Reactome:R-HSA-8936621|Reactome:R-HSA-8937050|Reactome:R-HSA-8936481|Reactome:R-HSA-1214188|Reactome:R-HSA-8937016|Reactome:R-HSA-8865498|Reactome:R-HSA-3364026 molecular_function owl:Class
GO:0075017 biolink:NamedThing regulation of appressorium formation Any process that modulates the frequency, rate or extent of symbiont appressorium formation. got7fsn_ti regulation of appressorium formation on or near host biological_process owl:Class
GO:0036156 biolink:NamedThing inner dynein arm Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility. got7fsn_ti inner dynein arm complex bf 2012-03-21T01:24:54Z cellular_component owl:Class
GO:1902756 biolink:NamedThing sulfurated eukaryotic molybdenum cofactor(2-) biosynthetic process The chemical reactions and pathways resulting in the formation of sulfurated eukaryotic molybdenum cofactor(2-). got7fsn_ti sulfurated eukaryotic molybdenum cofactor(2-) anabolism|sulfurated eukaryotic molybdenum cofactor(2-) biosynthesis|sulfurated eukaryotic molybdenum cofactor(2-) formation|sulfurated eukaryotic molybdenum cofactor(2-) synthesis dph 2014-03-05T23:29:20Z MetaCyc:PWY-6476|Reactome:R-HSA-947581 biological_process owl:Class
GO:0120321 biolink:NamedThing nuclear envelope adjacent to nuclear pore complex The region of the nuclear envelope situated in close proximity to a nuclear pore complex. got7fsn_ti associated with the nuclear pore|nuclear envelope periphery of the nuclear pore complex|nuclear envelope adjacent to NPC https://github.com/geneontology/go-ontology/issues/21774 krc 2021-07-07T20:30:21Z cellular_component owl:Class
GO:0034551 biolink:NamedThing mitochondrial respiratory chain complex III assembly The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex (also known as ubiquinol-cytochrome c reductase), in the mitochondrial inner membrane. got7fsn_ti mitochondrial cytochrome bc(1) complex assembly biological_process owl:Class
GO:0022849 biolink:NamedThing glutamate-gated calcium ion channel activity Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. got7fsn_ti molecular_function owl:Class
CHEBI:29108 biolink:NamedThing got7fsn_ti owl:Class
GO:0014019 biolink:NamedThing neuroblast development The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron. got7fsn_ti biological_process owl:Class
GO:0009539 biolink:NamedThing photosystem II reaction center An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone. got7fsn_ti photosystem II reaction centre cellular_component owl:Class
GO:0031500 biolink:NamedThing Tea1 cell-end complex A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity. got7fsn_ti cellular_component owl:Class
GO:0150201 biolink:NamedThing positive regulation of transport across blood-brain barrier Any process that activates or increases the frequency, rate or extent of transport across blood-brain barrier. got7fsn_ti bc 2020-03-26T19:26:38Z biological_process owl:Class
GO:1905305 biolink:NamedThing negative regulation of cardiac myofibril assembly Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly. got7fsn_ti inhibition of cardiac myofibril development|down-regulation of cardiac myofibril assembly|negative regulation of cardiac myofibril development|downregulation of heart myofibril assembly|down-regulation of cardiac myofibril development|downregulation of cardiac myofibril morphogenesis|down regulation of heart myofibril assembly|down regulation of cardiac myofibril morphogenesis|negative regulation of cardiac myofibril morphogenesis|inhibition of cardiac myofibril assembly|down-regulation of cardiac myofibril morphogenesis|downregulation of cardiac myofibril assembly|down regulation of cardiac myofibril assembly|down regulation of cardiac myofibril development|inhibition of cardiac myofibril morphogenesis|downregulation of cardiac myofibril development|inhibition of heart myofibril assembly|down-regulation of heart myofibril assembly|negative regulation of heart myofibril assembly rl 2016-07-06T10:01:58Z biological_process owl:Class
GO:0038027 biolink:NamedThing apolipoprotein A-I-mediated signaling pathway A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti apolipoprotein A-I-mediated signalling pathway bf 2011-08-02T02:13:41Z biological_process owl:Class
GO:0090708 biolink:NamedThing specification of plant organ axis polarity The process in which the polarity of a plant organ axis is specified. got7fsn_ti tb 2016-10-05T12:47:11Z biological_process owl:Class
GO:1903436 biolink:NamedThing regulation of mitotic cytokinetic process Any process that modulates the frequency, rate or extent of mitotic cytokinetic process. got7fsn_ti tb 2014-09-15T23:11:38Z biological_process owl:Class
PO:0009062 biolink:NamedThing got7fsn_ti owl:Class
GO:0072180 biolink:NamedThing mesonephric duct morphogenesis The process in which the anatomical structures of the mesonephric duct are generated and organized. A mesonephric duct is a tube drains the mesonephros. got7fsn_ti Wolffian duct morphogenesis mah 2010-02-26T02:37:13Z biological_process owl:Class
GO:0075306 biolink:NamedThing regulation of conidium formation Any process that modulates the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. got7fsn_ti biological_process owl:Class
GO:0098745 biolink:NamedThing Dcp1-Dcp2 complex A protein complex consisting of a Dcp1 regulatory subunit and a Dcp2 catalytic subunit that has mRNA cap binding activity and is involved in decapping of nuclear-transcribed mRNA. got7fsn_ti Additional components may be present, for example in ascomycetes this complex includes an additional regulatory subunit, Edc1. cellular_component owl:Class
GO:0072560 biolink:NamedThing type B pancreatic cell maturation A developmental process, independent of morphogenetic (shape) change, that is required for a type B pancreatic cell to attain its fully functional state. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin. got7fsn_ti pancreatic beta cell maturation|pancreatic B cell maturation These processes continue to 60 DPA in Gossypium spp. mah 2011-01-27T01:57:14Z biological_process owl:Class
GO:0021647 biolink:NamedThing vestibulocochlear nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. got7fsn_ti CN VIII maturation|auditory nerve maturation biological_process owl:Class
GO:0010840 biolink:NamedThing regulation of circadian sleep/wake cycle, wakefulness Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep. got7fsn_ti biological_process owl:Class
GO:1903178 biolink:NamedThing positive regulation of tyrosine 3-monooxygenase activity Any process that activates or increases the frequency, rate or extent of tyrosine 3-monooxygenase activity. got7fsn_ti activation of tyrosine hydroxylase activity|up-regulation of tyrosine 3-monooxygenase activity|upregulation of L-tyrosine hydroxylase activity|up regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|up regulation of L-tyrosine hydroxylase activity|upregulation of tyrosine 3-hydroxylase activity|stimulation of TH activity|activation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|up-regulation of tyrosine 3-hydroxylase activity|positive regulation of tyrosine 3-hydroxylase activity|upregulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|up-regulation of tyrosine hydroxylase activity|upregulation of tyrosine hydroxylase activity|up regulation of tyrosine 3-monooxygenase activity|positive regulation of tyrosine hydroxylase activity|positive regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|activation of L-tyrosine hydroxylase activity|up-regulation of L-tyrosine hydroxylase activity|positive regulation of L-tyrosine hydroxylase activity|activation of tyrosine 3-monooxygenase activity|up-regulation of L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)|up regulation of tyrosine 3-hydroxylase activity|up regulation of tyrosine hydroxylase activity|upregulation of tyrosine 3-monooxygenase activity|positive regulation of TH activity|activation of tyrosine 3-hydroxylase activity bf 2014-07-14T10:39:21Z biological_process owl:Class
GO:0002787 biolink:NamedThing negative regulation of antibacterial peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production. got7fsn_ti down-regulation of antibacterial peptide production|down regulation of antibacterial peptide production|inhibition of antibacterial peptide production|downregulation of antibacterial peptide production biological_process owl:Class
GO:0071341 biolink:NamedThing medial cortical node A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis. got7fsn_ti midsome|mid1p medial cortical dot mah 2009-12-11T11:40:36Z cellular_component owl:Class
GO:0001227 biolink:NamedThing DNA-binding transcription repressor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets transcribed by RNA polymerase II. got7fsn_ti RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription|RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding|metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific|RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding|RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, metal ion regulated sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription|proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific https://github.com/geneontology/go-ontology/issues/16534|https://github.com/geneontology/go-ontology/issues/16152|https://github.com/geneontology/go-ontology/issues/16131|https://github.com/geneontology/go-ontology/issues/20253 For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. krc 2010-10-26T03:56:48Z GO:0001206|GO:0001210|GO:0001078|GO:0001214 molecular_function owl:Class
GO:0035732 biolink:NamedThing nitric oxide storage The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins. got7fsn_ti NO storage bf 2011-03-11T10:00:31Z biological_process owl:Class
GO:0061233 biolink:NamedThing mesonephric glomerular basement membrane development The process whose specific outcome is the progression of the mesonephric glomerular basement membrane over time, from its formation to the mature structure. The mesonephric glomerular basement membrane is the basal laminal portion of the mesonephric glomerulus which performs the actual filtration. got7fsn_ti dph 2010-08-19T02:52:18Z biological_process owl:Class
GO:0050922 biolink:NamedThing negative regulation of chemotaxis Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient. got7fsn_ti down-regulation of chemotaxis|inhibition of chemotaxis|downregulation of chemotaxis|down regulation of chemotaxis biological_process owl:Class
GO:0007086 biolink:NamedThing vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly. got7fsn_ti biological_process owl:Class
GO:0097751 biolink:NamedThing spore-bearing structure formation The process of generating a spore-bearing structure. A spore-bearing structure is an anatomical structure that produces new spores. got7fsn_ti sporangium formation|sporophore formation pr 2017-01-11T13:55:24Z biological_process owl:Class
GO:0070149 biolink:NamedThing mitochondrial glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA in a mitochondrion, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0043294 biolink:NamedThing mitochondrial glutamate synthase complex (NADH) A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity. got7fsn_ti cellular_component owl:Class
GO:0030257 biolink:NamedThing type III protein secretion system complex A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase. got7fsn_ti TTSS complex|T3SS complex cellular_component owl:Class
GO:0035157 biolink:NamedThing negative regulation of fusion cell fate specification Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates. got7fsn_ti inhibition of fusion cell fate specification|downregulation of fusion cell fate specification|down-regulation of fusion cell fate specification|down regulation of fusion cell fate specification biological_process owl:Class
GO:1903108 biolink:NamedThing regulation of mitochondrial transcription Any process that modulates the frequency, rate or extent of transcription occuring in the mitochondrion. got7fsn_ti regulation of mitochondrial transcription|regulation of transcription from mitochondrial promoter al 2014-06-09T11:53:14Z biological_process owl:Class
PO:0000084 biolink:NamedThing got7fsn_ti owl:Class
GO:0004383 biolink:NamedThing guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. got7fsn_ti guanylyl cyclase activity|receptor guanylate cyclase activity|GTP diphosphate-lyase (cyclizing) activity|GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity|guanyl cyclase activity Reactome:R-HSA-392152|RHEA:13665|Reactome:R-HSA-74885|MetaCyc:GUANYLCYC-RXN|EC:4.6.1.2 molecular_function owl:Class
GO:0061687 biolink:NamedThing detoxification of inorganic compound Any process that reduces or removes the toxicity of inorganic compounds. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of inorganic compounds. got7fsn_ti dph 2015-03-09T09:16:23Z biological_process owl:Class
GO:0048041 biolink:NamedThing focal adhesion assembly The aggregation and bonding together of a set of components to form a focal adhesion, a complex of intracellular signaling and structural proteins that provides a structural link between the internal actin cytoskeleton and the ECM, and also function as a locus of signal transduction activity. got7fsn_ti focal adhesion formation|adhesion plaque assembly biological_process owl:Class
GO:0009424 biolink:NamedThing bacterial-type flagellum hook The portion of the bacterial-type flagellum that connects the filament to the basal body. got7fsn_ti flagellar hook|flagellin-based flagellum hook cellular_component owl:Class
GO:0048394 biolink:NamedThing intermediate mesodermal cell fate determination The process in which a cell becomes capable of differentiating autonomously into a intermediate mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti intermediate mesoderm cell fate determination biological_process owl:Class
GO:0015889 biolink:NamedThing cobalamin transport The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti vitamin B12 transport biological_process owl:Class
GO:0099175 biolink:NamedThing regulation of postsynapse organization Any process that modulates the physical form of a postsynapse. got7fsn_ti regulation of postsynapse organization and biogenesis|regulation of postsynapse organisation|regulation of postsynapse structure biological_process owl:Class
GO:0070125 biolink:NamedThing mitochondrial translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in a mitochondrion. got7fsn_ti mitochondrial translation elongation biological_process owl:Class
GO:1903933 biolink:NamedThing negative regulation of DNA primase activity Any process that stops, prevents or reduces the frequency, rate or extent of DNA primase activity. got7fsn_ti down-regulation of DNA primase activity|down regulation of DNA primase activity|inhibition of DNA primase activity|downregulation of DNA primase activity mah 2015-02-12T14:28:36Z biological_process owl:Class
GO:0021663 biolink:NamedThing rhombomere 4 formation The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0071698 biolink:NamedThing olfactory placode development The progression of the olfactory placode over time from its initial formation until its mature state. The olfactory placode is a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. got7fsn_ti mah 2010-03-02T12:45:14Z biological_process owl:Class
GO:0040037 biolink:NamedThing negative regulation of fibroblast growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity. got7fsn_ti inhibition of fibroblast growth factor receptor signaling pathway|negative regulation of FGF receptor signalling pathway|negative regulation of FGF receptor signaling pathway|down-regulation of fibroblast growth factor receptor signaling pathway|negative regulation of FGFR signaling pathway|down regulation of fibroblast growth factor receptor signaling pathway|downregulation of fibroblast growth factor receptor signaling pathway biological_process owl:Class
GO:0048084 biolink:NamedThing positive regulation of adult chitin-containing cuticle pigmentation Any process that activates or increases the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. got7fsn_ti up regulation of adult chitin-containing cuticle pigmentation|activation of adult chitin-containing cuticle pigmentation|up-regulation of adult chitin-containing cuticle pigmentation|upregulation of adult chitin-containing cuticle pigmentation|stimulation of adult chitin-containing cuticle pigmentation biological_process owl:Class
GO:0021615 biolink:NamedThing glossopharyngeal nerve morphogenesis The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. got7fsn_ti CN IX morphogenesis biological_process owl:Class
GO:0021563 biolink:NamedThing glossopharyngeal nerve development Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. got7fsn_ti CN IX development|cranial nerve 9 development|cranial nerve IX development biological_process owl:Class
GO:1905662 biolink:NamedThing negative regulation of telomerase RNA reverse transcriptase activity Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity. got7fsn_ti inhibition of telomerase, catalyst|down regulation of telomerase RNA reverse transcriptase activity|downregulation of telomerase RNA reverse transcriptase activity|down-regulation of telomerase RNA reverse transcriptase activity|inhibition of telomerase RNA reverse transcriptase activity|downregulation of telomerase, catalyst|negative regulation of telomerase, catalyst|down-regulation of telomerase, catalyst|down regulation of telomerase, catalyst nc 2016-11-09T16:55:28Z biological_process owl:Class
GO:0008837 biolink:NamedThing diaminopimelate epimerase activity Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate. got7fsn_ti LL-2,6-diaminoheptanedioate 2-epimerase activity MetaCyc:DIAMINOPIMEPIM-RXN|RHEA:15393|EC:5.1.1.7|KEGG_REACTION:R02735 molecular_function owl:Class
GO:0120121 biolink:NamedThing tripartite attachment complex A three-part cytoskeletal structure in kinetoplastid species linking mitochondrial DNA organised in a kinetoplast through the mitochondrial membranes to the basal body. got7fsn_ti TAC krc 2017-12-12T00:07:37Z cellular_component owl:Class
GO:0035001 biolink:NamedThing dorsal trunk growth, open tracheal system Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system. got7fsn_ti dorsal trunk growth biological_process owl:Class
GO:1903298 biolink:NamedThing negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway. got7fsn_ti inhibition of intrinsic apoptotic signaling pathway in response to hypoxia|down-regulation of intrinsic apoptotic signaling pathway in response to hypoxia|protection against hypoxia-induced apoptosis|down regulation of intrinsic apoptotic signaling pathway in response to hypoxia|negative regulation of hypoxic stress-induced intrinsic apoptotic signaling pathway|negative regulation of hypoxia-induced apoptosis|negative regulation of intrinsic apoptotic signaling pathway in response to hypoxia|downregulation of intrinsic apoptotic signaling pathway in response to hypoxia bf 2014-08-14T14:47:56Z biological_process owl:Class
GO:0035218 biolink:NamedThing leg disc development Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura. got7fsn_ti biological_process owl:Class
GO:0005537 biolink:NamedThing mannose binding Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. got7fsn_ti mannose binding lectin Reactome:R-HSA-947991 molecular_function owl:Class
GO:0043012 biolink:NamedThing regulation of fusion of sperm to egg plasma membrane Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane. got7fsn_ti regulation of sperm-oocyte fusion biological_process owl:Class
GO:1902897 biolink:NamedThing regulation of postsynaptic density protein 95 clustering Any process that modulates the frequency, rate or extent of postsynaptic density protein 95 clustering. got7fsn_ti regulation of post-synaptic density protein 95 clustering|regulation of PSD-95 clustering|regulation of Dlg4 clustering als 2014-04-09T14:52:08Z biological_process owl:Class
GO:0038177 biolink:NamedThing death receptor agonist activity Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor. got7fsn_ti death receptor activator activity bf 2012-09-20T12:52:00Z molecular_function owl:Class
GO:0022851 biolink:NamedThing GABA-gated chloride ion channel activity Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts. got7fsn_ti molecular_function owl:Class
GO:0019097 biolink:NamedThing pole plasm mitochondrial srRNA localization Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. got7fsn_ti establishment and maintenance of mitochondrial localization in pole plasm|oocyte pole plasm mitochondrial srRNA localization|pole plasm mitochondrial srRNA localisation GO:0048119 biological_process owl:Class
GO:0071100 biolink:NamedThing alphaV-beta8 integrin-MMP14-TGFbeta-1 complex A protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1). got7fsn_ti ITGAV-ITGB8-MMP14-TGFB1 complex mah 2009-11-06T04:52:43Z cellular_component owl:Class
GO:1902232 biolink:NamedThing regulation of positive thymic T cell selection Any process that modulates the frequency, rate or extent of positive thymic T cell selection. got7fsn_ti regulation of positive thymic T-lymphocyte selection|regulation of positive thymic T lymphocyte selection|regulation of positive thymic T-cell selection lb 2013-06-14T11:19:09Z biological_process owl:Class
GO:0006406 biolink:NamedThing mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm. got7fsn_ti mRNA-nucleus export|mRNA export from cell nucleus|mRNA transport from nucleus to cytoplasm|mRNA export out of nucleus biological_process owl:Class
GO:0060481 biolink:NamedThing lobar bronchus epithelium development The biological process whose specific outcome is the progression of a lobar bronchus epithelium from an initial condition to its mature state. This process begins with the formation of the lobar bronchus epithelium and ends with the mature structure. The lobar bronchus epithelium is the tissue made up of epithelial cells that lines the inside of the lobar bronchus. got7fsn_ti biological_process owl:Class
GO:0033230 biolink:NamedThing ABC-type cysteine transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(out/in) = ADP + phosphate + cysteine(in/out). got7fsn_ti ATP-dependent cysteine transporter activity|ATPase-coupled cysteine transmembrane transporter activity|cysteine-exporting ATPase activity|cysteine-transporting ATPase activity|cysteine exporter|ATPase-coupled cysteine transporter activity https://github.com/geneontology/go-ontology/issues/17289 GO:0032519 molecular_function owl:Class
GO:1903712 biolink:NamedThing cysteine transmembrane transport The directed movement of cysteine across a membrane. got7fsn_ti vw 2014-12-06T08:15:06Z biological_process owl:Class
CHEBI:58165 biolink:NamedThing got7fsn_ti owl:Class
GO:0043549 biolink:NamedThing regulation of kinase activity Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. got7fsn_ti biological_process owl:Class
GO:0060682 biolink:NamedThing primary ureteric bud growth The process in which the primary ureteric bud grows along its axis dorsally toward the metanephric blastema. got7fsn_ti dph 2009-06-02T02:56:01Z biological_process owl:Class
GO:0035379 biolink:NamedThing carbon dioxide transmembrane transporter activity Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other. got7fsn_ti bf 2010-03-18T11:19:38Z Reactome:R-HSA-1247649|Reactome:R-HSA-1237069|Reactome:R-HSA-1237042|Reactome:R-HSA-1247645 molecular_function owl:Class
GO:0035378 biolink:NamedThing carbon dioxide transmembrane transport The process in which carbon dioxide (CO2) is transported across a membrane. got7fsn_ti carbon dioxide membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-03-18T11:17:54Z biological_process owl:Class
GO:0060440 biolink:NamedThing trachea formation The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches. got7fsn_ti biological_process owl:Class
GO:0043506 biolink:NamedThing regulation of JUN kinase activity Any process that modulates the frequency, rate or extent of JUN kinase activity. got7fsn_ti regulation of JUNK activity biological_process owl:Class
GO:0090139 biolink:NamedThing mitochondrial DNA packaging Any process in which mitochondrial DNA and associated proteins are formed into a compact, orderly structure. got7fsn_ti tb 2009-12-08T02:12:19Z biological_process owl:Class
GO:1900260 biolink:NamedThing negative regulation of RNA-directed 5'-3' RNA polymerase activity Any process that stops, prevents or reduces the frequency, rate or extent of RNA-directed 5'-3' RNA polymerase activity. got7fsn_ti inhibition of phage f2 replicase|down-regulation of PB2 proteins|down-regulation of RNA synthetase activity|down regulation of Q-beta replicase activity|downregulation of transcriptase|down regulation of PB2 proteins|negative regulation of 3D polymerase activity|down regulation of RNA synthetase activity|downregulation of RNA synthetase activity|negative regulation of RNA nucleotidyltransferase (RNA-directed) activity|down regulation of polymerase L|down-regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|downregulation of ribonucleic replicase activity|down regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|inhibition of RNA-dependent RNA polymerase activity|downregulation of RNA-dependent RNA polymerase activity|down-regulation of RNA-dependent RNA polymerase activity|down-regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|down regulation of RNA nucleotidyltransferase (RNA-directed) activity|downregulation of RNA-directed RNA polymerase activity|down regulation of transcriptase|negative regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|down-regulation of ribonucleic replicase activity|inhibition of polymerase L|negative regulation of RNA synthetase activity|inhibition of ribonucleic replicase activity|negative regulation of ribonucleic replicase activity|down regulation of 3D polymerase activity|down-regulation of RDRP|downregulation of PB2 proteins|downregulation of polymerase L|inhibition of RNA nucleotidyltransferase (RNA-directed) activity|negative regulation of RNA-directed RNA polymerase activity|down regulation of ribonucleic acid replicase activity|downregulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|down regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|negative regulation of PB2 proteins|downregulation of RNA replicase activity|inhibition of ribonucleic acid replicase activity|inhibition of RDRP|down regulation of RDRP|downregulation of RNA nucleotidyltransferase (RNA-directed) activity|down-regulation of 3D polymerase activity|negative regulation of RNA replicase activity|down regulation of ribonucleic replicase activity|down-regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|inhibition of PB1 proteins|negative regulation of PB1 proteins|down-regulation of RNA-directed RNA polymerase activity|inhibition of Q-beta replicase activity|negative regulation of ribonucleic acid replicase activity|inhibition of PB2 proteins|down-regulation of transcriptase|down-regulation of RNA-dependent RNA replicase activity|down-regulation of polymerase L|down-regulation of phage f2 replicase|negative regulation of phage f2 replicase|down-regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|down-regulation of RNA replicase activity|negative regulation of Q-beta replicase activity|negative regulation of RNA-dependent ribonucleate nucleotidyltransferase activity|negative regulation of RNA-dependent RNA polymerase activity|downregulation of RNA-dependent RNA replicase activity|down-regulation of PB1 proteins|down regulation of phage f2 replicase|downregulation of Q-beta replicase activity|downregulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|negative regulation of RNA-dependent RNA replicase activity|downregulation of RDRP|downregulation of PB1 proteins|inhibition of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|inhibition of RNA replicase activity|negative regulation of RDRP|downregulation of ribonucleic synthetase activity|inhibition of RNA-dependent RNA replicase activity|inhibition of RNA-dependent ribonucleate nucleotidyltransferase activity|down regulation of RNA-dependent RNA polymerase activity|downregulation of 3D polymerase activity|down regulation of ribonucleic synthetase activity|negative regulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|downregulation of phage f2 replicase|down-regulation of ribonucleic acid replicase activity|down regulation of ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity|inhibition of RNA-directed RNA polymerase activity|down regulation of RNA replicase activity|inhibition of transcriptase|down regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|negative regulation of transcriptase|negative regulation of ribonucleic acid-dependent ribonucleic acid polymerase activity|inhibition of RNA synthetase activity|down-regulation of ribonucleic synthetase activity|downregulation of RNA-dependent ribonucleate nucleotidyltransferase activity|downregulation of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|down regulation of RNA-directed RNA polymerase activity|inhibition of 3D polymerase activity|down-regulation of RNA nucleotidyltransferase (RNA-directed) activity|inhibition of ribonucleic synthetase activity|down regulation of PB1 proteins|negative regulation of polymerase L|inhibition of ribonucleic acid-dependent ribonucleic acid polymerase activity|down regulation of RNA-dependent RNA replicase activity|down-regulation of Q-beta replicase activity|downregulation of ribonucleic acid replicase activity|inhibition of nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)|negative regulation of ribonucleic synthetase activity tb 2012-04-03T11:02:03Z biological_process owl:Class
GO:0005745 biolink:NamedThing m-AAA complex Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria. got7fsn_ti cellular_component owl:Class
GO:0097736 biolink:NamedThing aerial mycelium formation The process by which hyphae grow in an upward or outward direction from the surface of the substrate; from there, propagative spores develop in or on characteristic structures that are distinctive of some fungal and bacterial species. The species that form an aerial mycelium develop conidiophores at the ends of the aerial hyphae. got7fsn_ti fertile mycelium formation|aerial hyphal growth pr 2016-10-14T14:25:22Z biological_process owl:Class
GO:0005183 biolink:NamedThing gonadotropin hormone-releasing hormone activity The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary. got7fsn_ti LHRH activity|gonadotrophin hormone-releasing hormone activity|luteinizing hormone/follicle-stimulating hormone releasing factor activity|luteinizing hormone-releasing hormone activity|GnRH activity|LH/FSH-RF|luteinizing hormone-releasing factor activity molecular_function owl:Class
GO:0006540 biolink:NamedThing glutamate decarboxylation to succinate The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes. got7fsn_ti gamma-aminobutyrate shunt|glutamate degradation via 4-aminobutyrate|glutamate degradation via GABA|GABA shunt|degradation of glutamate to succinate through GABA|4-aminobutyrate shunt Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively). MetaCyc:PWY-4321|MetaCyc:GLUDEG-I-PWY|MetaCyc:PWY3O-210 biological_process owl:Class
GO:0016558 biolink:NamedThing protein import into peroxisome matrix The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix. got7fsn_ti protein transport to peroxisome matrix|peroxisome matrix protein import biological_process owl:Class
GO:0010521 biolink:NamedThing telomerase inhibitor activity Binds to and stops, prevents or reduces the activity of telomerase. got7fsn_ti molecular_function owl:Class
GO:0015150 biolink:NamedThing fucose transmembrane transporter activity Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. got7fsn_ti molecular_function owl:Class
GO:0015756 biolink:NamedThing fucose transmembrane transport The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose. got7fsn_ti fucose transport biological_process owl:Class
GO:1901835 biolink:NamedThing positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA Any process that activates or increases the frequency, rate or extent of deadenylation-independent decapping of nuclear-transcribed mRNA. got7fsn_ti activation of deadenylylation-independent decapping|activation of deadenylation-independent decapping of nuclear-transcribed mRNA|upregulation of deadenylation-independent decapping of nuclear mRNA|up regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|positive regulation of deadenylylation-independent decapping|upregulation of deadenylation-independent decapping of nuclear-transcribed mRNA|up regulation of deadenylation-independent decapping of nuclear mRNA|up-regulation of deadenylation-independent decapping of nuclear mRNA|up regulation of deadenylylation-independent decapping|up-regulation of deadenylylation-independent decapping|activation of deadenylation-independent decapping of nuclear mRNA|positive regulation of deadenylation-independent decapping of nuclear mRNA|up-regulation of deadenylation-independent decapping of nuclear-transcribed mRNA|upregulation of deadenylylation-independent decapping al 2013-01-22T22:42:22Z biological_process owl:Class
GO:1905955 biolink:NamedThing negative regulation of endothelial tube morphogenesis Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis. got7fsn_ti down regulation of endothelial tube morphogenesis|down-regulation of endothelial tube morphogenesis|downregulation of endothelial tube morphogenesis|inhibition of endothelial tube morphogenesis rph 2017-02-21T15:17:31Z biological_process owl:Class
GO:0070164 biolink:NamedThing negative regulation of adiponectin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of adiponectin from a cell. got7fsn_ti inhibition of adiponectin secretion|downregulation of adiponectin secretion|down-regulation of adiponectin secretion|down regulation of adiponectin secretion biological_process owl:Class
GO:0021941 biolink:NamedThing negative regulation of cerebellar granule cell precursor proliferation The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation. got7fsn_ti inhibition of granule cell precursor proliferation|down-regulation of granule cell precursor proliferation|downregulation of granule cell precursor proliferation|down regulation of granule cell precursor proliferation biological_process owl:Class
GO:0032931 biolink:NamedThing histone acetyltransferase activity (H3-K56 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K56 specific) molecular_function owl:Class
GO:0005579 biolink:NamedThing membrane attack complex A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow. got7fsn_ti TCC|MAC|membrane attack complex protein beta2 chain|terminal complement complex|membrane attack complex protein alphaM chain Wikipedia:Complement_membrane_attack_complex cellular_component owl:Class
GO:1902902 biolink:NamedThing negative regulation of autophagosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly. got7fsn_ti inhibition of PAS formation|downregulation of autophagosome biosynthesis|down-regulation of autophagosome formation|down-regulation of PAS formation|down-regulation of autophagosome biosynthesis|downregulation of autophagic vacuole assembly|down-regulation of autophagic vacuole assembly|inhibition of autophagosome formation|inhibition of autophagosome biosynthesis|inhibition of autophagic vacuole formation|down regulation of autophagosome biosynthesis|negative regulation of autophagosome biosynthesis|down regulation of autophagosome formation|negative regulation of autophagosome formation|down regulation of autophagic vacuole formation|down regulation of autophagic vacuole assembly|down-regulation of autophagic vacuole formation|downregulation of autophagosome formation|negative regulation of autophagic vacuole formation|downregulation of autophagic vacuole formation|down regulation of PAS formation|negative regulation of autophagic vacuole assembly|negative regulation of PAS formation|downregulation of PAS formation|inhibition of autophagic vacuole assembly als 2014-04-15T10:37:40Z biological_process owl:Class
GO:0015421 biolink:NamedThing ABC-type oligopeptide transporter activity Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in). got7fsn_ti ATPase-coupled oligopeptide transmembrane transporter activity|ATP-dependent oligopeptide transmembrane transporter activity|oligopeptide ABC transporter|oligopeptide permease activity|ABC-type oligopeptide transporter|oligopeptide-transporting ATPase activity MetaCyc:3.6.3.23-RXN|Reactome:R-HSA-5223317|RHEA:37271|EC:7.4.2.6 molecular_function owl:Class
GO:0035672 biolink:NamedThing oligopeptide transmembrane transport The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. got7fsn_ti oligopeptide membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2011-02-08T02:18:07Z biological_process owl:Class
GO:0006335 biolink:NamedThing DNA replication-dependent nucleosome assembly The formation of nucleosomes on newly replicated DNA, coupled to strand elongation. got7fsn_ti biological_process owl:Class
GO:0009345 biolink:NamedThing glycine-tRNA ligase complex A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly). got7fsn_ti glycine-tRNA synthetase complex cellular_component owl:Class
GO:2000718 biolink:NamedThing regulation of maintenance of mitotic sister chromatid cohesion, centromeric Any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region. got7fsn_ti regulation of maintenance of centromeric mitotic sister chromatin cohesion|regulation of maintenance of mitotic sister chromatin cohesion at centromere|regulation of maintenance of sister chromatin cohesion at centromere at mitosis mah 2011-06-03T10:41:11Z biological_process owl:Class
GO:0061354 biolink:NamedThing planar cell polarity pathway involved in pericardium morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the pericardium. got7fsn_ti dph 2010-10-01T03:12:53Z biological_process owl:Class
GO:0003344 biolink:NamedThing pericardium morphogenesis The process in which the anatomical structure of the pericardium is generated and organized. got7fsn_ti dph 2009-12-01T10:46:34Z biological_process owl:Class
GO:0000085 biolink:NamedThing mitotic G2 phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis. got7fsn_ti G2 phase of mitotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:2001189 biolink:NamedThing negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. got7fsn_ti negative regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|negative regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|negative regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell yaf 2011-11-03T01:31:36Z biological_process owl:Class
GO:0000239 biolink:NamedThing pachytene The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Meiosis#Pachytene|Wikipedia:Pachytene biological_process owl:Class
GO:1905470 biolink:NamedThing positive regulation of clathrin-coated pit assembly Any process that activates or increases the frequency, rate or extent of clathrin-coated pit assembly. got7fsn_ti up-regulation of clathrin-coated pit formation|activation of coated pit assembly|up-regulation of clathrin-coated pit assembly|up regulation of coated pit formation|up regulation of coated pit assembly|positive regulation of coated pit assembly|up-regulation of coated pit assembly|up regulation of clathrin-coated pit assembly|activation of clathrin-coated pit assembly|positive regulation of coated pit formation|upregulation of coated pit formation|up-regulation of coated pit formation|positive regulation of clathrin-coated pit formation|upregulation of coated pit assembly|activation of clathrin-coated pit formation|up regulation of clathrin-coated pit formation|upregulation of clathrin-coated pit assembly|upregulation of clathrin-coated pit formation|activation of coated pit formation bf 2016-09-20T10:04:53Z biological_process owl:Class
GO:0016557 biolink:NamedThing peroxisome membrane biogenesis The process in which a peroxisome membrane is synthesized, aggregates, and bonds together. got7fsn_ti biological_process owl:Class
GO:0030129 biolink:NamedThing clathrin coat of synaptic vesicle A clathrin coat found on a synaptic vesicle. got7fsn_ti cellular_component owl:Class
GO:0061907 biolink:NamedThing negative regulation of AMPA receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor activity. got7fsn_ti dph 2017-06-29T11:55:11Z biological_process owl:Class
GO:0005524 biolink:NamedThing ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. got7fsn_ti Reactome:R-HSA-265682 molecular_function owl:Class
GO:1901395 biolink:NamedThing regulation of transforming growth factor beta2 activation Any process that modulates the frequency, rate or extent of transforming growth factor beta2 activation. got7fsn_ti regulation of TGFB2 activation|regulation of TGFbeta 2 activation|regulation of TGF-beta 2 activation bf 2012-10-01T10:46:50Z biological_process owl:Class
GO:0120228 biolink:NamedThing outer dynein arm docking complex A complex which stabilizes the binding of and correctly positions the outer dynein arm complex along an A-tubule of the flagellar axoneme outer doublet microtubules. got7fsn_ti ODA-DC|ODA docking complex https://github.com/geneontology/go-ontology/issues/19588 krc 2020-06-05T23:30:44Z cellular_component owl:Class
GO:0016546 biolink:NamedThing male courtship behavior, proboscis-mediated licking The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster. got7fsn_ti male courtship behavior, licking|male courtship behaviour, proboscis-mediated licking|male courtship behaviour, licking biological_process owl:Class
GO:0070806 biolink:NamedThing negative regulation of phialide development Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. got7fsn_ti mah 2009-07-08T04:47:16Z biological_process owl:Class
GO:0000958 biolink:NamedThing mitochondrial mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion. got7fsn_ti biological_process owl:Class
GO:0060582 biolink:NamedThing cell fate determination involved in pattern specification A process involved in commitment of a cell to a fate in a developmental field. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. got7fsn_ti dph 2009-05-07T12:48:08Z biological_process owl:Class
GO:0098647 biolink:NamedThing collagen beaded filament A supramolecular assembly of collagen trimers with a 'beads on a string'-like structure. got7fsn_ti beads on a string cellular_component owl:Class
GO:0033172 biolink:NamedThing gas vesicle shell The proteinaceous structure surrounding a gas vesicle. got7fsn_ti gas vesicle membrane|gas vesicle wall cellular_component owl:Class
GO:0006363 biolink:NamedThing termination of RNA polymerase I transcription The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit. got7fsn_ti termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript|transcription termination from Pol I promoter|RNA polymerase I transcription termination|transcription termination from RNA polymerase I promoter|RNA polymerase I transcription termination factor activity krc 2011-08-15T04:07:43Z GO:0001185|GO:0019223 biological_process owl:Class
GO:0018109 biolink:NamedThing peptidyl-arginine phosphorylation The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine. got7fsn_ti RESID:AA0222 biological_process owl:Class
GO:0017077 biolink:NamedThing oxidative phosphorylation uncoupler activity Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. got7fsn_ti uncoupling protein activity|mitochondrial uncoupling protein activity GO:0015302 molecular_function owl:Class
GO:0052776 biolink:NamedThing diacetylchitobiose catabolic process to glucosamine and acetate The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate. got7fsn_ti biological_process owl:Class
GO:0043515 biolink:NamedThing kinetochore binding Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached. got7fsn_ti molecular_function owl:Class
GO:0120017 biolink:NamedThing ceramide transfer activity Removes a ceramide from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti ceramide transporter activity|ceramide carrier activity|intermembrane ceramide transfer activity https://github.com/geneontology/go-ontology/issues/12329 krc 2010-12-08T12:32:50Z GO:0035620 molecular_function owl:Class
GO:0097001 biolink:NamedThing ceramide binding Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes. got7fsn_ti pr 2011-03-09T11:34:09Z molecular_function owl:Class
GO:0002623 biolink:NamedThing negative regulation of B cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation. got7fsn_ti down-regulation of B cell antigen processing and presentation|downregulation of B cell antigen processing and presentation|inhibition of B cell antigen processing and presentation|down regulation of B cell antigen processing and presentation|negative regulation of B lymphocyte antigen processing and presentation|negative regulation of B-cell antigen processing and presentation|negative regulation of B-lymphocyte antigen processing and presentation biological_process owl:Class
GO:0003322 biolink:NamedThing pancreatic A cell development The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon. got7fsn_ti pancreatic alpha cell development dph 2009-11-02T08:13:55Z biological_process owl:Class
GO:0003310 biolink:NamedThing pancreatic A cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. got7fsn_ti pancreatic alpha cell differentiation dph 2009-10-26T09:28:05Z biological_process owl:Class
GO:0002905 biolink:NamedThing regulation of mature B cell apoptotic process Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process. got7fsn_ti regulation of mature B cell apoptosis biological_process owl:Class
CL:0000120 biolink:NamedThing got7fsn_ti owl:Class
GO:0070498 biolink:NamedThing interleukin-1-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-1 beta-mediated signaling pathway|interleukin-1 beta-mediated signaling pathway|IL-1-mediated signaling pathway|IL-1 alpha-mediated signaling pathway|interleukin-1 alpha-mediated signaling pathway|interleukin-1-mediated signalling pathway biological_process owl:Class
GO:0016183 biolink:NamedThing synaptic vesicle coating The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles. got7fsn_ti biological_process owl:Class
GO:0016185 biolink:NamedThing synaptic vesicle budding from presynaptic endocytic zone membrane Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle. got7fsn_ti synaptic vesicle budding from pre-synaptic membrane|synaptic vesicle budding involved in synaptic vesicle endocytosis biological_process owl:Class
GO:0006353 biolink:NamedThing DNA-templated transcription, termination The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. got7fsn_ti DNA-dependent transcription, termination|termination of DNA-dependent transcription|termination of transcription, DNA-dependent|transcription termination, DNA-dependent|transcription termination factor activity|transcriptional complex disassembly biological_process owl:Class
GO:0032414 biolink:NamedThing positive regulation of ion transmembrane transporter activity Any process that activates or increases the activity of an ion transporter. got7fsn_ti up regulation of ion transporter activity|upregulation of ion transporter activity|activation of ion transporter activity|stimulation of ion transporter activity|positive regulation of ion transporter activity|up-regulation of ion transporter activity biological_process owl:Class
GO:0061535 biolink:NamedThing glutamate secretion, neurotransmission The controlled release of glutamate by a cell, in which the glutamate acts as a neurotransmitter. got7fsn_ti dph 2013-06-21T16:14:47Z biological_process owl:Class
GO:2000232 biolink:NamedThing regulation of rRNA processing Any process that modulates the frequency, rate or extent of rRNA processing. got7fsn_ti regulation of 35S primary transcript processing mah 2010-11-10T12:11:29Z biological_process owl:Class
CL:0000182 biolink:NamedThing got7fsn_ti owl:Class
GO:1905792 biolink:NamedThing positive regulation of mechanosensory behavior Any process that activates or increases the frequency, rate or extent of mechanosensory behavior. got7fsn_ti up regulation of mechanosensory behaviour|up-regulation of mechanosensory behavior|up-regulation of behavioural response to mechanical stimulus|up-regulation of behavioral response to mechanical stimulus|up regulation of behavioral response to mechanical stimulus|positive regulation of mechanosensory behaviour|upregulation of mechanosensory behavior|upregulation of behavioral response to mechanical stimulus|up regulation of mechanosensory behavior|positive regulation of behavioral response to mechanical stimulus|positive regulation of behavioural response to mechanical stimulus|up-regulation of mechanosensory behaviour|upregulation of mechanosensory behaviour|activation of mechanosensory behaviour|up regulation of behavioural response to mechanical stimulus|activation of mechanosensory behavior|activation of behavioral response to mechanical stimulus|upregulation of behavioural response to mechanical stimulus|activation of behavioural response to mechanical stimulus hbye 2017-01-09T15:17:24Z biological_process owl:Class
GO:0002804 biolink:NamedThing positive regulation of antifungal peptide production Any process that activates or increases the frequency, rate, or extent of antifungal peptide production. got7fsn_ti stimulation of antifungal peptide production|activation of antifungal peptide production|upregulation of antifungal peptide production|up-regulation of antifungal peptide production|up regulation of antifungal peptide production biological_process owl:Class
GO:2001011 biolink:NamedThing positive regulation of plant-type cell wall cellulose biosynthetic process Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process. got7fsn_ti positive regulation of cellulose biosynthesis during cell wall biosynthesis|positive regulation of cell wall cellulose biosynthesis tt 2011-08-08T08:47:30Z biological_process owl:Class
GO:2000792 biolink:NamedThing positive regulation of mesenchymal cell proliferation involved in lung development Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development. got7fsn_ti pr 2011-06-24T01:53:56Z biological_process owl:Class
GO:0035175 biolink:NamedThing histone kinase activity (H3-S10 specific) Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3. got7fsn_ti histone-serine kinase activity (H3-S10 specific)|histone serine kinase activity (H3-S10 specific)|histone kinase activity (H3-S3 specific) GO:0044021 molecular_function owl:Class
GO:0002783 biolink:NamedThing antifungal peptide biosynthetic process The chemical reactions and pathways resulting in the formation of an antifungal peptide. got7fsn_ti biological_process owl:Class
GO:0022016 biolink:NamedThing pallium glioblast division The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells. got7fsn_ti glioblast cell division in pallium biological_process owl:Class
GO:0033088 biolink:NamedThing negative regulation of immature T cell proliferation in thymus Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus. got7fsn_ti negative regulation of thymocyte proliferation|negative regulation of thymic T cell proliferation|negative regulation of thymocyte cell proliferation biological_process owl:Class
GO:2001222 biolink:NamedThing regulation of neuron migration Any process that modulates the frequency, rate or extent of neuron migration. got7fsn_ti regulation of neuron guidance|regulation of neuronal migration|regulation of neuron chemotaxis kmv 2011-11-17T10:01:38Z biological_process owl:Class
GO:0050885 biolink:NamedThing neuromuscular process controlling balance Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors. got7fsn_ti regulation of balance biological_process owl:Class
GO:0001552 biolink:NamedThing ovarian follicle atresia A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed. got7fsn_ti biological_process owl:Class
UBERON:0001305 biolink:NamedThing got7fsn_ti owl:Class
GO:0095500 biolink:NamedThing acetylcholine receptor signaling pathway The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands. got7fsn_ti acetylcholine receptor signalling pathway biological_process owl:Class
GO:1905145 biolink:NamedThing cellular response to acetylcholine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus. got7fsn_ti dos 2016-04-14T08:54:58Z biological_process owl:Class
GO:0061557 biolink:NamedThing trigeminal ganglion maturation A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state. got7fsn_ti trigeminal ganglia maturation dph 2013-07-10T08:58:24Z biological_process owl:Class
GO:0072562 biolink:NamedThing blood microparticle A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. got7fsn_ti cell membrane microparticle mah 2011-01-28T11:50:56Z cellular_component owl:Class
GO:1903106 biolink:NamedThing positive regulation of insulin receptor signaling pathway involved in determination of adult lifespan Any process that activates or increases the frequency, rate or extent of insulin receptor signaling pathway involved in determination of adult lifespan. got7fsn_ti up-regulation of daf-2 receptor signaling pathway of determination of adult lifespan|activation of insulin receptor signalling pathway of determination of adult lifespan|up regulation of insulin receptor signaling pathway of determination of adult lifespan|up regulation of insulin receptor signalling pathway of determination of adult lifespan|up-regulation of insulin receptor signaling pathway of determination of adult lifespan|positive regulation of insulin receptor signalling pathway of determination of adult lifespan|upregulation of insulin receptor signaling pathway of determination of adult lifespan|upregulation of daf-2 receptor signaling pathway of determination of adult lifespan|upregulation of insulin receptor signalling pathway of determination of adult lifespan|activation of insulin receptor signaling pathway of determination of adult lifespan|upregulation of insulin receptor signaling pathway involved in determination of adult lifespan|activation of daf-2 receptor signaling pathway of determination of adult lifespan|up regulation of insulin receptor signaling pathway involved in determination of adult lifespan|activation of insulin receptor signaling pathway involved in determination of adult lifespan|positive regulation of insulin receptor signaling pathway of determination of adult lifespan|up-regulation of insulin receptor signalling pathway of determination of adult lifespan|up-regulation of insulin receptor signaling pathway involved in determination of adult lifespan|positive regulation of daf-2 receptor signaling pathway of determination of adult lifespan|up regulation of daf-2 receptor signaling pathway of determination of adult lifespan kmv 2014-06-05T20:56:19Z biological_process owl:Class
GO:0051972 biolink:NamedThing regulation of telomerase activity Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. got7fsn_ti telomerase regulator biological_process owl:Class
GO:0043850 biolink:NamedThing RecFOR complex A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair. got7fsn_ti cellular_component owl:Class
GO:1903052 biolink:NamedThing positive regulation of proteolysis involved in cellular protein catabolic process Any process that activates or increases the frequency, rate or extent of proteolysis involved in cellular protein catabolic process. got7fsn_ti up-regulation of proteolysis involved in cellular protein catabolic process|up regulation of peptidolysis involved in cellular protein catabolic process|up regulation of peptidolysis during cellular protein catabolic process|activation of proteolysis during cellular protein catabolism|positive regulation of peptidolysis during cellular protein catabolism|upregulation of peptidolysis during cellular protein catabolism|up-regulation of peptidolysis involved in cellular protein catabolic process|up regulation of peptidolysis during cellular protein catabolism|positive regulation of peptidolysis involved in cellular protein catabolism|activation of peptidolysis during cellular protein catabolism|activation of peptidolysis during cellular protein catabolic process|upregulation of peptidolysis involved in cellular protein catabolism|up-regulation of proteolysis during cellular protein catabolism|activation of peptidolysis involved in cellular protein catabolism|up regulation of proteolysis during cellular protein catabolic process|upregulation of peptidolysis involved in cellular protein catabolic process|upregulation of proteolysis during cellular protein catabolism|upregulation of proteolysis involved in cellular protein catabolic process|up regulation of peptidolysis involved in cellular protein catabolism|up-regulation of peptidolysis involved in cellular protein catabolism|activation of proteolysis during cellular protein catabolic process|up-regulation of proteolysis during cellular protein catabolic process|positive regulation of peptidolysis during cellular protein catabolic process|positive regulation of proteolysis during cellular protein catabolism|up regulation of proteolysis involved in cellular protein catabolic process|up-regulation of peptidolysis during cellular protein catabolic process|upregulation of peptidolysis during cellular protein catabolic process|upregulation of proteolysis during cellular protein catabolic process|up-regulation of peptidolysis during cellular protein catabolism|activation of peptidolysis involved in cellular protein catabolic process|positive regulation of proteolysis during cellular protein catabolic process|up regulation of proteolysis during cellular protein catabolism|positive regulation of peptidolysis involved in cellular protein catabolic process|activation of proteolysis involved in cellular protein catabolic process overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP) rl 2014-05-22T18:00:57Z biological_process owl:Class
GO:1905068 biolink:NamedThing positive regulation of canonical Wnt signaling pathway involved in heart development Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway involved in heart development. got7fsn_ti up-regulation of canonical Wnt signaling pathway involved in heart development|up regulation of canonical Wnt-activated signaling pathway involved in heart development|up regulation of canonical Wnt signaling pathway involved in heart development|up regulation of canonical Wnt receptor signalling pathway involved in heart development|positive regulation of canonical Wnt receptor signalling pathway involved in heart development|activation of canonical Wnt signaling pathway involved in heart development|up-regulation of canonical Wnt-activated signaling pathway involved in heart development|activation of canonical Wnt receptor signalling pathway involved in heart development|activation of canonical Wnt receptor signaling pathway involved in heart development|up regulation of canonical Wnt receptor signaling pathway involved in heart development|upregulation of canonical Wnt signaling pathway involved in heart development|activation of canonical Wnt-activated signaling pathway involved in heart development|up-regulation of canonical Wnt receptor signaling pathway involved in heart development|up-regulation of canonical Wnt receptor signalling pathway involved in heart development|upregulation of canonical Wnt receptor signalling pathway involved in heart development|upregulation of canonical Wnt-activated signaling pathway involved in heart development|upregulation of canonical Wnt receptor signaling pathway involved in heart development|positive regulation of canonical Wnt-activated signaling pathway involved in heart development|positive regulation of canonical Wnt receptor signaling pathway involved in heart development bc 2016-03-21T12:47:15Z biological_process owl:Class
GO:0060598 biolink:NamedThing dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis The process in which the terminal end of a mammary duct bifurcates. got7fsn_ti primary mammary duct branching dph 2009-05-13T12:16:29Z biological_process owl:Class
GO:0002799 biolink:NamedThing positive regulation of antibacterial peptide secretion Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion. got7fsn_ti up regulation of antibacterial peptide secretion|up-regulation of antibacterial peptide secretion|activation of antibacterial peptide secretion|stimulation of antibacterial peptide secretion|upregulation of antibacterial peptide secretion biological_process owl:Class
GO:0090636 biolink:NamedThing outer dense plaque of desmosome The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins, as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane. got7fsn_ti tb 2015-04-20T16:10:51Z cellular_component owl:Class
GO:0021704 biolink:NamedThing locus ceruleus morphogenesis The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic. got7fsn_ti biological_process owl:Class
GO:0010995 biolink:NamedThing free ubiquitin chain depolymerization The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down. got7fsn_ti tb 2009-06-03T11:45:42Z biological_process owl:Class
GO:0010992 biolink:NamedThing ubiquitin recycling Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates. got7fsn_ti regulation of ubiquitin homeostasis|ubiquitin homeostasis tb 2009-06-03T11:36:55Z GO:0010993 biological_process owl:Class
GO:0030174 biolink:NamedThing regulation of DNA-dependent DNA replication initiation Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase. got7fsn_ti regulation of DNA replication initiation|DNA replication licencing|DNA replication licensing biological_process owl:Class
GO:0003909 biolink:NamedThing DNA ligase activity Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+. got7fsn_ti Reactome:R-HSA-6782227|Reactome:R-HSA-5693604|Reactome:R-HSA-5690997|Reactome:R-HSA-69173|Reactome:R-HSA-174456|Reactome:R-HSA-73931|Reactome:R-HSA-5358592|Reactome:R-HSA-5687675|Reactome:R-HSA-5649734|Reactome:R-HSA-175258|Reactome:R-HSA-5651789|Reactome:R-HSA-5651805 molecular_function owl:Class
GO:0036301 biolink:NamedThing macrophage colony-stimulating factor production The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti M-CSF production bf 2012-08-07T14:07:13Z biological_process owl:Class
GO:0042685 biolink:NamedThing cardioblast cell fate specification The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti biological_process owl:Class
GO:0042684 biolink:NamedThing cardioblast cell fate commitment The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti biological_process owl:Class
GO:0015611 biolink:NamedThing ABC-type D-ribose transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in). got7fsn_ti D-ribose-importing ATPase activity|D-ribose porter activity RHEA:29903|MetaCyc:ABC-28-RXN|EC:7.5.2.8 molecular_function owl:Class
GO:0070771 biolink:NamedThing alphaIIb-beta3 integrin-CD47-Src complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase c-Src. got7fsn_ti ITGA2b-ITGB3-CD47-SRC complex mah 2009-06-29T05:46:53Z cellular_component owl:Class
GO:1901018 biolink:NamedThing positive regulation of potassium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity. got7fsn_ti positive regulation of potassium transporter activity|upregulation of potassium transporter activity|activation of potassium ion transmembrane transporter activity|up regulation of potassium ion transmembrane transporter activity|upregulation of potassium ion transmembrane transporter activity|up regulation of potassium transporter activity|up-regulation of potassium ion transmembrane transporter activity|up-regulation of potassium transporter activity|activation of potassium transporter activity rl 2012-06-15T01:14:18Z biological_process owl:Class
GO:0003350 biolink:NamedThing pulmonary myocardium development The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein. got7fsn_ti dph 2009-12-01T12:50:06Z biological_process owl:Class
GO:0060841 biolink:NamedThing venous blood vessel development The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed. got7fsn_ti dph 2009-08-12T10:14:07Z biological_process owl:Class
GO:1903376 biolink:NamedThing regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. got7fsn_ti regulation of neuron intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of neuron apoptosis in response to oxidative stress|regulation of oxidative stress-induced neuronal apoptosis|regulation of oxidative stress-induced neuron apoptosis bf 2014-08-26T13:03:13Z biological_process owl:Class
GO:0010888 biolink:NamedThing negative regulation of lipid storage Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. got7fsn_ti biological_process owl:Class
GO:0072327 biolink:NamedThing vulval cell fate specification The process in which a cell becomes capable of differentiating autonomously into a nematode vulval cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed adult vulva, which is the egg-laying organ of female and hermaphrodite nematodes. got7fsn_ti mah 2010-11-01T02:14:06Z biological_process owl:Class
GO:0048539 biolink:NamedThing bone marrow development The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0000221 biolink:NamedThing vacuolar proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. got7fsn_ti vacuolar hydrogen ion-transporting ATPase V1 domain Note that this domain generally consists of eight subunits. cellular_component owl:Class
GO:0016471 biolink:NamedThing vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. got7fsn_ti vacuolar hydrogen-translocating V-type ATPase complex See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. cellular_component owl:Class
GO:1905219 biolink:NamedThing regulation of platelet formation Any process that modulates the frequency, rate or extent of platelet formation. got7fsn_ti regulation of platelet extrusion sl 2016-06-06T22:15:46Z biological_process owl:Class
GO:1905206 biolink:NamedThing positive regulation of hydrogen peroxide-induced cell death Any process that activates or increases the frequency, rate or extent of cell death in response to hydrogen peroxide. got7fsn_ti up regulation of cell death in response to H2O2|up-regulation of cell death in response to H2O2|upregulation of cell death in response to hydrogen peroxide|positive regulation of cell death in response to hydrogen peroxide|up-regulation of hydrogen peroxide-mediated cell death|positive regulation of hydrogen peroxide-mediated cell death|up regulation of cell death in response to hydrogen peroxide|upregulation of hydrogen peroxide-mediated cell death|activation of hydrogen peroxide-mediated cell death|positive regulation of cell death in response to H2O2|up-regulation of cell death in response to hydrogen peroxide|up regulation of hydrogen peroxide-mediated cell death|activation of cell death in response to H2O2|upregulation of cell death in response to H2O2|activation of cell death in response to hydrogen peroxide bc 2016-05-20T13:13:39Z biological_process owl:Class
GO:0039594 biolink:NamedThing endoribonuclease activity involved in viral induction of host mRNA catabolic process Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA. got7fsn_ti GO:0039594 can be used to annotate a host or viral endoribonuclease activity that cleaves host mRNA in response to a viral infection. bf 2012-07-05T11:21:26Z molecular_function owl:Class
GO:0039599 biolink:NamedThing cleavage by virus of host mRNA Any process in which a host pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner by a viral endoribonuclease. got7fsn_ti viral endoribonuclease activity involved in degradation of host mRNA|host mRNA cleavage by viral endoribonuclease bf 2012-07-04T05:09:08Z biological_process owl:Class
GO:0043484 biolink:NamedThing regulation of RNA splicing Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. got7fsn_ti biological_process owl:Class
GO:0033597 biolink:NamedThing mitotic checkpoint complex A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. got7fsn_ti MCC cellular_component owl:Class
GO:0051033 biolink:NamedThing RNA transmembrane transporter activity Enables the transfer of RNA, ribonucleic acid, from one side of a membrane to the other. got7fsn_ti Reactome:R-HSA-203906 molecular_function owl:Class
GO:0048536 biolink:NamedThing spleen development The process whose specific outcome is the progression of the spleen over time, from its formation to the mature structure. The spleen is a large vascular lymphatic organ composed of white and red pulp, involved both in hemopoietic and immune system functions. got7fsn_ti biological_process owl:Class
GO:0002800 biolink:NamedThing regulation of antifungal peptide secretion Any process that modulates the frequency, rate, or extent of antifungal peptide secretion. got7fsn_ti biological_process owl:Class
GO:0003034 biolink:NamedThing detection of increased carbon dioxide by aortic body chemoreceptor signaling The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body. got7fsn_ti detection of increased carbon dioxide by aortic body chemoreceptor signalling biological_process owl:Class
GO:1903915 biolink:NamedThing positive regulation of fusion of virus membrane with host plasma membrane Any process that activates or increases the frequency, rate or extent of fusion of virus membrane with host plasma membrane. got7fsn_ti up-regulation of viral penetration via membrane fusion|positive regulation of viral envelope fusion with host membrane|upregulation of viral envelope fusion with host plasma membrane|up regulation of viral penetration via membrane fusion|upregulation of viral penetration via membrane fusion|up regulation of viral entry into host cell via membrane fusion with the plasma membrane|up-regulation of viral envelope fusion with host cell membrane|up-regulation of viral-cell fusion molecule activity|upregulation of viral-cell fusion molecule activity|activation of fusion of virus membrane with host plasma membrane|activation of viral-cell fusion molecule activity|up-regulation of fusion of virus membrane with host plasma membrane|up regulation of fusion of virus membrane with host plasma membrane|up-regulation of viral entry into host cell via membrane fusion with the plasma membrane|upregulation of viral entry into host cell via membrane fusion with the plasma membrane|positive regulation of viral envelope fusion with host plasma membrane|up regulation of viral-cell fusion molecule activity|activation of viral envelope fusion with host membrane|activation of viral envelope fusion with host plasma membrane|positive regulation of viral-cell fusion molecule activity|up-regulation of viral envelope fusion with host membrane|up regulation of viral envelope fusion with host cell membrane|up regulation of viral envelope fusion with host membrane|upregulation of viral envelope fusion with host cell membrane|up regulation of viral envelope fusion with host plasma membrane|positive regulation of viral entry into host cell via membrane fusion with the plasma membrane|up-regulation of viral envelope fusion with host plasma membrane|positive regulation of viral penetration via membrane fusion|activation of viral penetration via membrane fusion|activation of viral envelope fusion with host cell membrane|upregulation of viral envelope fusion with host membrane|positive regulation of viral envelope fusion with host cell membrane|activation of viral entry into host cell via membrane fusion with the plasma membrane|upregulation of fusion of virus membrane with host plasma membrane als 2015-02-09T11:13:41Z biological_process owl:Class
GO:0000959 biolink:NamedThing mitochondrial RNA metabolic process The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. got7fsn_ti biological_process owl:Class
GO:0090083 biolink:NamedThing regulation of inclusion body assembly Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body. got7fsn_ti tb 2009-10-23T11:07:22Z biological_process owl:Class
GO:1905295 biolink:NamedThing regulation of neural crest cell fate specification Any process that modulates the frequency, rate or extent of neural crest cell fate specification. got7fsn_ti rl 2016-06-28T15:14:40Z biological_process owl:Class
GO:0031065 biolink:NamedThing positive regulation of histone deacetylation Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones. got7fsn_ti up regulation of histone deacetylation|activation of histone deacetylation|upregulation of histone deacetylation|up-regulation of histone deacetylation|stimulation of histone deacetylation biological_process owl:Class
GO:0010719 biolink:NamedThing negative regulation of epithelial to mesenchymal transition Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. got7fsn_ti biological_process owl:Class
GO:0072287 biolink:NamedThing metanephric distal tubule morphogenesis The process in which the anatomical structures of a metanephric distal tubule are generated and organized. The metanephric distal tubule is a metanephric nephron tubule that begins at the macula densa and extends to the metanephric connecting tubule. got7fsn_ti mah 2010-04-09T03:41:47Z biological_process owl:Class
GO:0061382 biolink:NamedThing Malpighian tubule tip cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule tip cell. A Malpighian tubule tip cell is a mitogenic signaling cell that controls the proliferation of its neighboring cells. got7fsn_ti dph 2010-11-23T09:52:44Z biological_process owl:Class
GO:0048452 biolink:NamedThing petal structural organization The process that contributes to the act of creating the structural organization of the petal. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti petal structural organisation GO:0048420 biological_process owl:Class
GO:1903374 biolink:NamedThing subarachnoid space development The process whose specific outcome is the progression of a subarachnoid space over time, from its formation to the mature structure. got7fsn_ti subarachnoid cavity development|spatium subarachnoideum development|spatium leptomeningeum development|cavum subarachnoideale development|cavitas subarachnoidea development https://github.com/geneontology/go-ontology/issues/21883 pr 2014-08-22T12:20:56Z biological_process owl:Class
GO:0061139 biolink:NamedThing bud field specification The regionalization process in which the identity of a bud primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti dph 2010-05-25T09:21:01Z biological_process owl:Class
GO:1904073 biolink:NamedThing regulation of trophectodermal cell proliferation Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation. got7fsn_ti regulation of trophectoderm cell proliferation tb 2015-03-20T16:55:56Z biological_process owl:Class
GO:0061442 biolink:NamedThing cardiac muscle cell fate determination The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment. got7fsn_ti dph 2012-03-13T08:59:57Z biological_process owl:Class
GO:0039640 biolink:NamedThing viral release by cytolysis via suppression of host peptidoglycan biosynthetic process The killing by a virus of host cell by cytolysis, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls. got7fsn_ti viral exit by cytolysis via suppression of host peptidoglycan biosynthetic process|cytolysis by virus via suppression of host peptidoglycan biosynthetic process https://github.com/geneontology/go-ontology/issues/18852 bf 2012-08-17T10:54:55Z biological_process owl:Class
GO:0003024 biolink:NamedThing baroreceptor detection of decreased arterial stretch The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal. got7fsn_ti biological_process owl:Class
GO:0033289 biolink:NamedThing intraconoid microtubule A microtubule located such that it threads through the conoid and projects through the polar ring. got7fsn_ti cellular_component owl:Class
GO:0120168 biolink:NamedThing detection of hot stimulus involved in thermoception The series of events in which a hot stimulus is received and converted into a molecular signal as part of thermoception. got7fsn_ti sensory transduction of hot stimulus during thermoception|thermoception, sensory transduction of hot stimulus|sensory transduction of heat stimulus during thermoception|sensory detection of heat stimulus during thermoception|thermoception, sensory detection of heat stimulus|sensory detection of hot stimulus during thermoception|thermoception, sensory detection of hot stimulus|thermoception, sensory transduction of heat stimulus krc 2018-05-21T20:35:47Z biological_process owl:Class
GO:0060315 biolink:NamedThing negative regulation of ryanodine-sensitive calcium-release channel activity Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. got7fsn_ti biological_process owl:Class
GO:0042700 biolink:NamedThing luteinizing hormone signaling pathway The series of molecular signals mediated by luteinizing hormone. got7fsn_ti luteinizing hormone signalling pathway biological_process owl:Class
GO:0007398 biolink:NamedThing ectoderm development The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation. got7fsn_ti biological_process owl:Class
GO:0043029 biolink:NamedThing T cell homeostasis The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti T-cell homeostasis|T-lymphocyte homeostasis|T lymphocyte homeostasis Note that this term represents the return of T cell levels to stable numbers following an immune response as well as the proliferation and elimination of T cells required to maintain stable numbers in the absence of an outside stimulus. biological_process owl:Class
GO:0002797 biolink:NamedThing regulation of antibacterial peptide secretion Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion. got7fsn_ti biological_process owl:Class
GO:0001406 biolink:NamedThing glycerophosphodiester transmembrane transporter activity Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. got7fsn_ti molecular_function owl:Class
GO:0001407 biolink:NamedThing glycerophosphodiester transmembrane transport The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol. got7fsn_ti biological_process owl:Class
GO:0002225 biolink:NamedThing positive regulation of antimicrobial peptide production Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production. got7fsn_ti stimulation of antimicrobial peptide production|upregulation of antimicrobial peptide production|up regulation of antimicrobial peptide production|antimicrobial peptide induction|activation of antimicrobial peptide production|up-regulation of antimicrobial peptide production biological_process owl:Class
GO:0008582 biolink:NamedThing regulation of synaptic assembly at neuromuscular junction Any process that modulates the frequency, rate or extent of synaptic assembly at neuromuscular junctions. got7fsn_ti regulation of synaptic growth at neuromuscular junction biological_process owl:Class
GO:0004533 biolink:NamedThing exoribonuclease H activity Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions. got7fsn_ti retroviral reverse transcriptase RNaseH MetaCyc:3.1.13.2-RXN|EC:3.1.13.2 molecular_function owl:Class
GO:1990317 biolink:NamedThing Gin4 complex A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved. got7fsn_ti Gin4-septin complex bhm 2014-03-14T12:07:05Z cellular_component owl:Class
GO:0000921 biolink:NamedThing septin ring assembly The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex. got7fsn_ti septin assembly and septum biosynthesis|septin assembly and septum formation biological_process owl:Class
GO:0031516 biolink:NamedThing far-red light photoreceptor activity The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation. got7fsn_ti molecular_function owl:Class
GO:0002572 biolink:NamedThing pro-T cell differentiation The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed. got7fsn_ti pro-T lymphocyte differentiation biological_process owl:Class
GO:0021881 biolink:NamedThing Wnt-activated signaling pathway involved in forebrain neuron fate commitment The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain. got7fsn_ti Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt-activated signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signalling pathway involved in forebrain neuron fate commitment biological_process owl:Class
GO:0099151 biolink:NamedThing regulation of postsynaptic density assembly Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density. got7fsn_ti dos 2017-07-05T13:20:48Z biological_process owl:Class
GO:0001655 biolink:NamedThing urogenital system development The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0016514 biolink:NamedThing SWI/SNF complex A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. got7fsn_ti SWI-SNF complex cellular_component owl:Class
GO:0080181 biolink:NamedThing lateral root branching Any process involved in the formation of branches in lateral roots. got7fsn_ti dhl 2011-08-10T04:13:33Z biological_process owl:Class
GO:0004455 biolink:NamedThing ketol-acid reductoisomerase activity Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. got7fsn_ti ketol acid reductoisomerase activity|dihydroxyisovalerate dehydrogenase (isomerizing) activity|acetohydroxy acid isomeroreductase activity|isomeroreductase activity|2-hydroxy-3-keto acid reductoisomerase activity|dihydroxyisovalerate (isomerizing) dehydrogenase activity|acetolactate reductoisomerase activity|reductoisomerase activity|alpha-keto-beta-hydroxylacyl reductoisomerase activity|(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)|acetohydroxy acid reductoisomerase activity EC:1.1.1.86|MetaCyc:ACETOLACTREDUCTOISOM-RXN|RHEA:22068 molecular_function owl:Class
GO:0110113 biolink:NamedThing positive regulation of lipid transporter activity Any process that increases the frequency, rate, or extent of lipid transporter activity. got7fsn_ti kmv 2018-07-06T19:14:13Z biological_process owl:Class
GO:0060769 biolink:NamedThing positive regulation of epithelial cell proliferation involved in prostate gland development Any process that increases the rate, frequency or extent of epithelial cell proliferation that contributes to the progression of the prostate gland over time. got7fsn_ti dph 2009-07-08T07:38:02Z biological_process owl:Class
GO:0045275 biolink:NamedThing respiratory chain complex III A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. got7fsn_ti complex III|electron transport complex III|coenzyme Q-cytochrome c reductase complex|CoQH2-cytochrome c reductase complex|ubiquinol-cytochrome c oxidoreductase complex|ubiquinol-cytochrome-c reductase complex|cytochrome bc1 complex|coenzyme Q-cytochrome c oxidoreductase complex|cytochrome bc(1) complex GO:0032842|GO:0045285 Wikipedia:Coenzyme_Q_-_cytochrome_c_reductase cellular_component owl:Class
GO:0019452 biolink:NamedThing L-cysteine catabolic process to taurine The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine. got7fsn_ti L-cysteine breakdown to taurine|L-cysteine degradation to taurine biological_process owl:Class
GO:0061285 biolink:NamedThing mesonephric capsule development The progression of the mesonephric capsule over time, from its formation to the mature structure. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. got7fsn_ti dph 2010-09-02T01:50:06Z biological_process owl:Class
GO:1902797 biolink:NamedThing negative regulation of snoRNA processing Any process that stops, prevents or reduces the frequency, rate or extent of snoRNA processing. got7fsn_ti down-regulation of snoRNA processing|inhibition of snoRNA processing|down regulation of snoRNA processing|downregulation of snoRNA processing mah 2014-03-24T12:47:08Z biological_process owl:Class
GO:0110110 biolink:NamedThing positive regulation of animal organ morphogenesis Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis. got7fsn_ti kmv 2018-07-05T14:10:14Z biological_process owl:Class
GO:0072191 biolink:NamedThing ureter smooth muscle development The process whose specific outcome is the progression of smooth muscle in the ureter over time, from its formation to the mature structure. got7fsn_ti mah 2010-03-01T01:48:53Z biological_process owl:Class
GO:0072264 biolink:NamedThing metanephric glomerular endothelium development The process whose specific outcome is the progression of the metanephric glomerular endothelium over time, from its formation to the mature structure. The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros. got7fsn_ti mah 2010-03-30T02:42:26Z biological_process owl:Class
GO:0010707 biolink:NamedThing globoside biosynthetic process via lactosylceramide The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. got7fsn_ti lactosylceramide biosynthesis leading to globoside|globoside biosynthesis via lactosylceramide biosynthesis|biosynthesis of lactosylceramide precursor to globoside|lactosylceramide biosynthetic process leading to globoside biological_process owl:Class
GO:2000078 biolink:NamedThing positive regulation of type B pancreatic cell development Any process that activates or increases the frequency, rate or extent of pancreatic B cell development. got7fsn_ti positive regulation of pancreatic beta cell development|positive regulation of pancreatic B cell development tb 2010-08-27T11:21:19Z biological_process owl:Class
GO:0021554 biolink:NamedThing optic nerve development The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. got7fsn_ti cranial nerve 2 development|CN II development|cranial nerve II development biological_process owl:Class
CL:0000119 biolink:NamedThing got7fsn_ti owl:Class
GO:0046799 biolink:NamedThing recruitment of helicase-primase complex to DNA lesions The recruitment of the helicase-primase complex to viral DNA lesions during viral DNA repair. got7fsn_ti biological_process owl:Class
GO:0060130 biolink:NamedThing thyroid-stimulating hormone-secreting cell development The process whose specific outcome is the progression of a thyroid-stimulating hormone-secreting cell over time, from its formation to the mature structure. A thyroid-stimulating hormone-secreting cell is a basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. got7fsn_ti thyrotrope development|thyroid stimulating hormone secreting cell development|TSH-secreting cell development|beta-basophil development|thyrotroph development biological_process owl:Class
GO:0002626 biolink:NamedThing negative regulation of T cell antigen processing and presentation Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation. got7fsn_ti negative regulation of T-lymphocyte antigen processing and presentation|inhibition of T cell antigen processing and presentation|negative regulation of T lymphocyte antigen processing and presentation|downregulation of T cell antigen processing and presentation|down regulation of T cell antigen processing and presentation|down-regulation of T cell antigen processing and presentation|negative regulation of T-cell antigen processing and presentation biological_process owl:Class
GO:0003163 biolink:NamedThing sinoatrial node development The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. got7fsn_ti SAN development|sinus node development|SA node development dph 2009-10-01T02:06:09Z biological_process owl:Class
GO:0005577 biolink:NamedThing fibrinogen complex A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. got7fsn_ti fibrinogen beta chain|fibrinogen alpha chain|fibrinogen gamma chain|fibrinogen cellular_component owl:Class
GO:0003292 biolink:NamedThing cardiac septum cell differentiation The process in which an endocardial cushion cell becomes a cell of a cardiac septum. got7fsn_ti dph 2009-10-20T11:03:46Z biological_process owl:Class
GO:1904115 biolink:NamedThing axon cytoplasm Any cytoplasm that is part of a axon. got7fsn_ti axoplasm sl 2015-04-06T18:13:14Z cellular_component owl:Class
GO:0061168 biolink:NamedThing regulation of hair follicle placode formation Any process that modulates the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. got7fsn_ti dph 2010-06-25T01:03:29Z biological_process owl:Class
GO:0015252 biolink:NamedThing proton channel activity Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti hydrogen ion channel activity molecular_function owl:Class
GO:2000265 biolink:NamedThing positive regulation of blood coagulation, extrinsic pathway Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway. got7fsn_ti mah 2010-11-23T11:44:46Z biological_process owl:Class
GO:0015438 biolink:NamedThing ABC-type teichoic acid transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out). got7fsn_ti ABC-type teichoic-acid transporter|teichoic acid transmembrane transporter activity|ATPase-coupled teichoic acid transmembrane transporter activity|teichoic-acid-transporting ATPase activity|teichoic-acid ABC transporter|ATP-dependent teichoic acid transmembrane transporter activity GO:0015162 EC:7.5.2.4|MetaCyc:3.6.3.40-RXN molecular_function owl:Class
GO:0015777 biolink:NamedThing teichoic acid transport The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues. got7fsn_ti biological_process owl:Class
GO:0000183 biolink:NamedThing rDNA heterochromatin assembly The assembly of chromatin characterized by the modified histone H3K9me3, into heterochromatin, resulting in the repression of transcription of rDNA. got7fsn_ti chromatin silencing at ribosomal DNA|rDNA chromatin silencing|heterochromatic silencing at rDNA|chromatin silencing at rDNA https://github.com/geneontology/go-ontology/issues/19238 biological_process owl:Class
GO:0060708 biolink:NamedThing spongiotrophoblast differentiation The process in which a relatively unspecialized cell of the ectoplacental cone acquires specialized features of a spongiotrophoblast of the placenta. A spongiotrophoblast cell is a basophilic cell. got7fsn_ti spongiotrophoblast cell differentiation dph 2009-06-09T10:38:10Z biological_process owl:Class
GO:0001545 biolink:NamedThing primary ovarian follicle growth Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle). got7fsn_ti biological_process owl:Class
GO:0048727 biolink:NamedThing posterior cibarial plate development The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:1903300 biolink:NamedThing negative regulation of hexokinase activity Any process that stops, prevents or reduces the frequency, rate or extent of hexokinase activity. got7fsn_ti down regulation of glucose ATP phosphotransferase activity|inhibition of hexokinase activity|down regulation of ATP-dependent hexokinase activity|inhibition of glucose ATP phosphotransferase activity|negative regulation of hexokinase type IV glucokinase activity|down-regulation of hexokinase type I activity|negative regulation of hexokinase (phosphorylating)|inhibition of hexokinase type IV|down regulation of hexokinase (phosphorylating)|negative regulation of hexokinase type I activity|down regulation of hexokinase D|down regulation of hexokinase activity|downregulation of hexokinase D|negative regulation of hexokinase type III activity|inhibition of hexokinase type IV glucokinase activity|inhibition of hexokinase type III activity|down-regulation of glucose ATP phosphotransferase activity|down regulation of hexokinase type IV (glucokinase) activity|down-regulation of hexokinase type III activity|down-regulation of hexokinase type IV glucokinase activity|negative regulation of hexokinase D|inhibition of hexokinase type IV (glucokinase) activity|down regulation of hexokinase type IV glucokinase activity|down-regulation of hexokinase type IV (glucokinase) activity|inhibition of hexokinase type I activity|negative regulation of hexokinase type II activity|downregulation of hexokinase type IV|down-regulation of hexokinase type IV|downregulation of hexokinase type IV glucokinase activity|downregulation of glucose ATP phosphotransferase activity|downregulation of hexokinase type III activity|inhibition of ATP-dependent hexokinase activity|down-regulation of hexokinase type II activity|downregulation of hexokinase activity|downregulation of hexokinase type II activity|inhibition of hexokinase (phosphorylating)|negative regulation of hexokinase type IV|downregulation of hexokinase type I activity|downregulation of ATP:D-hexose 6-phosphotransferase activity|negative regulation of hexokinase type IV (glucokinase) activity|negative regulation of ATP:D-hexose 6-phosphotransferase activity|down-regulation of hexokinase D|down-regulation of hexokinase (phosphorylating)|negative regulation of ATP-dependent hexokinase activity|downregulation of hexokinase type IV (glucokinase) activity|down regulation of hexokinase type I activity|down regulation of hexokinase type III activity|down regulation of hexokinase type II activity|downregulation of ATP-dependent hexokinase activity|down regulation of hexokinase type IV|down regulation of ATP:D-hexose 6-phosphotransferase activity|down-regulation of ATP:D-hexose 6-phosphotransferase activity|negative regulation of glucose ATP phosphotransferase activity|inhibition of ATP:D-hexose 6-phosphotransferase activity|down-regulation of hexokinase activity|down-regulation of ATP-dependent hexokinase activity|inhibition of hexokinase D|inhibition of hexokinase type II activity|downregulation of hexokinase (phosphorylating) mr 2014-08-15T23:18:01Z biological_process owl:Class
GO:0003165 biolink:NamedThing Purkinje myocyte development The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle. got7fsn_ti cardiac Purkinje fiber development dph 2009-10-01T02:07:50Z biological_process owl:Class
GO:0015218 biolink:NamedThing pyrimidine nucleotide transmembrane transporter activity Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0006864 biolink:NamedThing pyrimidine nucleotide transport The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell. got7fsn_ti biological_process owl:Class
GO:0022018 biolink:NamedThing lateral ganglionic eminence cell proliferation The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population. got7fsn_ti biological_process owl:Class
GO:0097281 biolink:NamedThing immune complex formation The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus. got7fsn_ti antibody-mediated agglutination pr 2012-03-26T01:35:21Z biological_process owl:Class
GO:0007088 biolink:NamedThing regulation of mitotic nuclear division Any process that modulates the frequency, rate or extent of mitosis. got7fsn_ti regulation of mitosis biological_process owl:Class
GO:0010884 biolink:NamedThing positive regulation of lipid storage Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. got7fsn_ti positive regulation of lipid sequestration biological_process owl:Class
GO:1901698 biolink:NamedThing response to nitrogen compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus. got7fsn_ti response to nitrogen molecular entity pr 2012-12-13T15:06:08Z biological_process owl:Class
GO:0035078 biolink:NamedThing induction of programmed cell death by ecdysone Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death. got7fsn_ti biological_process owl:Class
GO:0035075 biolink:NamedThing response to ecdysone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus. got7fsn_ti biological_process owl:Class
GO:0086089 biolink:NamedThing voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization dph 2011-11-22T01:33:01Z molecular_function owl:Class
GO:0003160 biolink:NamedThing endocardium morphogenesis The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. got7fsn_ti dph 2009-10-01T01:37:26Z biological_process owl:Class
GO:0021737 biolink:NamedThing emboliform nucleus development The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0015224 biolink:NamedThing biopterin transmembrane transporter activity Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme. got7fsn_ti biopterin transporter activity molecular_function owl:Class
GO:0015877 biolink:NamedThing biopterin transport The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme. got7fsn_ti biological_process owl:Class
GO:0048797 biolink:NamedThing swim bladder formation The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ. got7fsn_ti gas bladder formation|gas bladder biosynthesis biological_process owl:Class
GO:0009998 biolink:NamedThing negative regulation of retinal cone cell fate specification Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell. got7fsn_ti down-regulation of retinal cone cell fate specification|negative regulation of retina cone cell fate specification|down regulation of retinal cone cell fate specification|suppression of retinal cone cell fate|downregulation of retinal cone cell fate specification|suppression of retina cone cell fate|inhibition of retinal cone cell fate specification biological_process owl:Class
GO:0071953 biolink:NamedThing elastic fiber An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. got7fsn_ti elastin fiber|elastic fibre mah 2010-10-11T11:44:57Z cellular_component owl:Class
GO:0030450 biolink:NamedThing regulation of complement activation, classical pathway Any process that modulates the frequency, rate or extent of the classical pathway of complement activation. got7fsn_ti regulation of complement cascade, classical pathway biological_process owl:Class
GO:2000043 biolink:NamedThing regulation of cardiac cell fate specification Any process that modulates the frequency, rate or extent of cardiac cell fate specification. got7fsn_ti tb 2010-08-19T09:01:04Z biological_process owl:Class
GO:0015119 biolink:NamedThing hexose phosphate transmembrane transporter activity Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule. got7fsn_ti molecular_function owl:Class
GO:0015712 biolink:NamedThing hexose phosphate transport The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0035524 biolink:NamedThing proline transmembrane transport The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore. got7fsn_ti proline membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-05-04T04:52:46Z biological_process owl:Class
GO:1990483 biolink:NamedThing Clr6 histone deacetylase complex I'' A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3. got7fsn_ti al 2014-09-16T10:40:51Z cellular_component owl:Class
GO:2000233 biolink:NamedThing negative regulation of rRNA processing Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing. got7fsn_ti negative regulation of 35S primary transcript processing mah 2010-11-10T12:11:33Z biological_process owl:Class
GO:0106250 biolink:NamedThing DNA-binding transcription repressor activity, RNA polymerase III-specific A DNA-binding transcription factor activity that represses or decreases the transcription of specific genes sets transcribed by RNA polymerase III. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20253 For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. hjd 2020-02-19T19:34:18Z molecular_function owl:Class
GO:0002364 biolink:NamedThing NK T cell lineage commitment The process in which a pro-T cell becomes committed to becoming an NK T cell. got7fsn_ti NK T-cell lineage commitment|natural killer T-cell lineage commitment|natural killer T lymphocyte lineage commitment|natural killer T-lymphocyte lineage commitment|NK T lymphocyte lineage commitment|NK T-lymphocyte lineage commitment biological_process owl:Class
GO:0001865 biolink:NamedThing NK T cell differentiation The process in which a precursor cell type acquires the specialized features of a NK T cell. got7fsn_ti NK T lymphocyte differentiation|NKT cell differentiation|NK T cell development|natural T cell differentiation|natural killer T cell differentiation|NK T-lymphocyte differentiation|NT cell differentiation|NK T-cell differentiation Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0038173 biolink:NamedThing interleukin-17A-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL17a signaling pathway|IL-17A-mediated signaling pathway|interleukin-17A signaling pathway|IL17A signaling pathway|interleukin-17A-mediated signalling pathway bf 2012-06-12T10:59:01Z biological_process owl:Class
GO:0062089 biolink:NamedThing regulation of taurine biosynthetic process Any process that modulates the rate, frequency or extent of taurine biosynthesis. got7fsn_ti dph 2018-11-07T14:05:44Z biological_process owl:Class
GO:0071600 biolink:NamedThing otic vesicle morphogenesis The process in which the anatomical structures of the otic vesicle are generated and organized. The otic vesicle is a transient embryonic structure formed during development of the vertebrate inner ear. got7fsn_ti mah 2010-02-04T04:07:27Z biological_process owl:Class
GO:1903681 biolink:NamedThing regulation of epithelial cell-cell adhesion involved in epithelium migration Any process that modulates the frequency, rate or extent of epithelial cell-cell adhesion involved in epithelium migration. got7fsn_ti als 2014-12-01T13:25:05Z biological_process owl:Class
GO:1905376 biolink:NamedThing negative regulation of cytochrome-c oxidase activity Any process that stops, prevents or reduces the frequency, rate or extent of cytochrome-c oxidase activity. got7fsn_ti downregulation of cytochrome a3 activity|negative regulation of cytochrome c oxidase activity|inhibition of cytochrome oxidase activity|negative regulation of complex IV (mitochondrial electron transport) activity|down regulation of indophenol oxidase|inhibition of ferrocytochrome-c:oxygen oxidoreductase|inhibition of NADH cytochrome c oxidase|inhibition of ferrocytochrome c oxidase|inhibition of ba3-type cytochrome c oxidase|down regulation of cbb3-type cytochrome c oxidase|negative regulation of ba3-type cytochrome c oxidase|downregulation of cytochrome c oxidase activity|down regulation of indophenolase|inhibition of indophenolase|down-regulation of indophenolase|down-regulation of cytochrome c oxidase activity|down-regulation of cytochrome-c oxidase activity|downregulation of cytochrome aa3 activity|downregulation of cytochrome-c oxidase activity|down regulation of ferrocytochrome c oxidase|down-regulation of indophenol oxidase|down regulation of cytochrome c oxidase activity|down-regulation of NADH cytochrome c oxidase|down regulation of warburg's respiratory enzyme activity|down-regulation of cytochrome aa3 activity|down-regulation of cytochrome oxidase activity|down regulation of cytochrome aa3 activity|down regulation of aa3-type cytochrome c oxidase|down regulation of ferrocytochrome-c:oxygen oxidoreductase|negative regulation of cytochrome aa3 activity|down-regulation of aa3-type cytochrome c oxidase|negative regulation of indophenolase|inhibition of aa3-type cytochrome c oxidase|down-regulation of complex IV (mitochondrial electron transport) activity|inhibition of cytochrome a3 activity|downregulation of indophenol oxidase|down-regulation of warburg's respiratory enzyme activity|down regulation of NADH cytochrome c oxidase|downregulation of indophenolase|downregulation of aa3-type cytochrome c oxidase|inhibition of cytochrome-c oxidase activity|negative regulation of ferrocytochrome-c:oxygen oxidoreductase|negative regulation of caa3-type cytochrome c oxidase|down-regulation of ferrocytochrome-c:oxygen oxidoreductase|negative regulation of indophenol oxidase|downregulation of caa3-type cytochrome c oxidase|downregulation of ferrocytochrome-c:oxygen oxidoreductase|down-regulation of ferrocytochrome c oxidase|down regulation of cytochrome-c oxidase activity|inhibition of indophenol oxidase|down-regulation of ba3-type cytochrome c oxidase|downregulation of cytochrome oxidase activity|downregulation of warburg's respiratory enzyme activity|down-regulation of cytochrome a3 activity|negative regulation of ferrocytochrome c oxidase|down regulation of complex IV (mitochondrial electron transport) activity|negative regulation of cytochrome oxidase activity|inhibition of cytochrome c oxidase activity|negative regulation of warburg's respiratory enzyme activity|negative regulation of aa3-type cytochrome c oxidase|negative regulation of cytochrome a3 activity|down-regulation of caa3-type cytochrome c oxidase|inhibition of cbb3-type cytochrome c oxidase|inhibition of warburg's respiratory enzyme activity|inhibition of complex IV (mitochondrial electron transport) activity|down-regulation of cbb3-type cytochrome c oxidase|down regulation of cytochrome oxidase activity|negative regulation of cbb3-type cytochrome c oxidase|down regulation of cytochrome a3 activity|downregulation of NADH cytochrome c oxidase|negative regulation of NADH cytochrome c oxidase|downregulation of ferrocytochrome c oxidase|downregulation of ba3-type cytochrome c oxidase|inhibition of caa3-type cytochrome c oxidase|downregulation of cbb3-type cytochrome c oxidase|down regulation of caa3-type cytochrome c oxidase|down regulation of ba3-type cytochrome c oxidase|inhibition of cytochrome aa3 activity|downregulation of complex IV (mitochondrial electron transport) activity sl 2016-08-17T20:29:57Z biological_process owl:Class
GO:0032832 biolink:NamedThing regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. got7fsn_ti regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response|regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0017076 biolink:NamedThing purine nucleotide binding Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. got7fsn_ti molecular_function owl:Class
GO:0051191 biolink:NamedThing prosthetic group biosynthetic process The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. got7fsn_ti prosthetic group formation|prosthetic group biosynthesis|coenzyme and prosthetic group biosynthetic process|coenzyme and prosthetic group biosynthesis|prosthetic group anabolism|prosthetic group synthesis biological_process owl:Class
GO:1900439 biolink:NamedThing positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to chemical stimulus. got7fsn_ti up-regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|up regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|upregulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus|activation of filamentous growth of a population of unicellular organisms in response to chemical stimulus di 2012-04-25T05:55:35Z biological_process owl:Class
GO:2000787 biolink:NamedThing regulation of venous endothelial cell fate commitment Any process that modulates the frequency, rate or extent of venous endothelial cell fate commitment. got7fsn_ti bf 2011-06-24T01:26:12Z biological_process owl:Class
GO:0001781 biolink:NamedThing neutrophil apoptotic process Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. got7fsn_ti neutrophil apoptosis|programmed cell death of neutrophils by apoptosis|neutrophil programmed cell death by apoptosis|programmed cell death, neutrophils|apoptosis of neutrophils biological_process owl:Class
GO:1900864 biolink:NamedThing mitochondrial RNA modification Any RNA modification that takes place in mitochondrion. got7fsn_ti mitochondrial RNA editing tb 2012-06-11T10:49:56Z biological_process owl:Class
GO:0032118 biolink:NamedThing horsetail-astral microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis. got7fsn_ti horsetail-astral microtubule organisation|horsetail-astral microtubule array organization|horsetail-astral microtubule organization and biogenesis biological_process owl:Class
GO:0030062 biolink:NamedThing mitochondrial tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle. got7fsn_ti TCA cycle enzyme complex cellular_component owl:Class
GO:2001211 biolink:NamedThing negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway Any process that stops, prevents or reduces the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. got7fsn_ti negative regulation of isopentenyl diphosphate synthesis, mevalonate pathway|negative regulation of acetate-mevalonate pathway|negative regulation of isopentenyl diphosphate anabolism, mevalonate pathway|negative regulation of isopentenyl diphosphate formation, mevalonate pathway|negative regulation of Ac-MVA pathway bf 2011-11-15T10:53:45Z biological_process owl:Class
GO:0021540 biolink:NamedThing corpus callosum morphogenesis The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres. got7fsn_ti biological_process owl:Class
GO:1902677 biolink:NamedThing left caudal basal body Any ciliary basal body that is part of a left caudal flagellum found in Giardia species (trophozoite stage). got7fsn_ti microtubule basal body of left caudal cilium|ciliary basal body of left caudal flagellum|cilial basal body of left caudal flagellum|cilium basal body of left caudal cilium|left caudal flagellum ciliary basal body|cilial basal body of left caudal cilium|ciliary basal body of left caudal cilium|microtubule basal body of left caudal flagellum|cilium basal body of left caudal flagellum Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T15:00:36Z cellular_component owl:Class
GO:0061219 biolink:NamedThing mesonephric mesenchyme development The biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros. got7fsn_ti dph 2010-08-17T03:45:44Z biological_process owl:Class
GO:0034634 biolink:NamedThing glutathione transmembrane transporter activity Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0034775 biolink:NamedThing glutathione transmembrane transport A process in which glutathione is transported across a membrane. got7fsn_ti transmembrane glutathione transport|glutathione membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. biological_process owl:Class
GO:0044190 biolink:NamedThing host cell mitochondrial envelope The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space. got7fsn_ti jl 2009-10-15T04:12:55Z cellular_component owl:Class
GO:0021597 biolink:NamedThing central nervous system structural organization The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. got7fsn_ti central nervous system structural organisation biological_process owl:Class
GO:0021551 biolink:NamedThing central nervous system morphogenesis The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord. got7fsn_ti biological_process owl:Class
GO:0005896 biolink:NamedThing interleukin-6 receptor complex A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130. got7fsn_ti IL-6 receptor complex cellular_component owl:Class
CL:0000746 biolink:NamedThing got7fsn_ti owl:Class
GO:0033029 biolink:NamedThing regulation of neutrophil apoptotic process Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process. got7fsn_ti regulation of neutrophil apoptosis biological_process owl:Class
GO:0090428 biolink:NamedThing perianth development The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals. got7fsn_ti tb 2012-05-08T06:02:15Z biological_process owl:Class
GO:1905423 biolink:NamedThing positive regulation of plant organ morphogenesis Any process that activates or increases the frequency, rate or extent of plant organ morphogenesis. got7fsn_ti upregulation of plant organ morphogenesis|activation of plant organ morphogenesis|up-regulation of plant organ morphogenesis|up regulation of plant organ morphogenesis tb 2016-09-06T23:00:29Z biological_process owl:Class
GO:0120317 biolink:NamedThing sperm mitochondrial sheath assembly The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. got7fsn_ti krc 2021-04-29T01:52:38Z biological_process owl:Class
CL:0000847 biolink:NamedThing got7fsn_ti owl:Class
GO:0071690 biolink:NamedThing cardiac muscle myosin thick filament assembly The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in cardiac muscle. got7fsn_ti mah 2010-02-25T03:55:44Z biological_process owl:Class
GO:0042813 biolink:NamedThing Wnt-activated receptor activity Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti frizzled receptor activity|Wnt receptor activity|frizzled-2 receptor activity molecular_function owl:Class
GO:1904823 biolink:NamedThing purine nucleobase transmembrane transport The process in which a purine nucleobase is transported across a membrane. got7fsn_ti vw 2015-11-19T09:07:56Z biological_process owl:Class
GO:0009573 biolink:NamedThing chloroplast ribulose bisphosphate carboxylase complex A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana. got7fsn_ti chloroplast RubisCO complex cellular_component owl:Class
GO:0032043 biolink:NamedThing mitochondrial DNA catabolic process The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA. got7fsn_ti mitochondrial DNA degradation|mtDNA breakdown|mitochondrial DNA catabolism|mtDNA catabolism|mitochondrial DNA breakdown|mtDNA degradation|mtDNA catabolic process biological_process owl:Class
GO:1905822 biolink:NamedThing regulation of mitotic sister chromatid arm separation Any process that modulates the frequency, rate or extent of mitotic sister chromatid arm separation. got7fsn_ti als 2017-01-16T13:36:29Z biological_process owl:Class
GO:0072598 biolink:NamedThing protein localization to chloroplast A process in which a protein is transported to, or maintained at, a location in a chloroplast. got7fsn_ti protein localisation to chloroplast mah 2011-02-14T02:20:30Z biological_process owl:Class
GO:0097740 biolink:NamedThing paraflagellar rod A large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. Protein components of the paraflagellar rod are likely implicated, among other, in adenine nucleotide signalling and metabolism, and in calcium signalling. got7fsn_ti PFR pr 2016-10-19T11:30:08Z cellular_component owl:Class
GO:0043865 biolink:NamedThing methionine transmembrane transporter activity Enables the transfer of methionine from one side of a membrane to the other. got7fsn_ti methionine importer activity|methionine-importing activity|methionine importing activity|methionine importer pr 2013-11-15T10:35:04Z GO:1990240 molecular_function owl:Class
GO:0015821 biolink:NamedThing methionine transport The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-methionine transport biological_process owl:Class
GO:0002943 biolink:NamedThing tRNA dihydrouridine synthesis The process whereby a uridine in a transfer RNA is converted to dihydrouridine. got7fsn_ti Dihydrouridine is found in numerous positions within loop I, the so-called dihydrouridine loop, of many transfer RNAs. Most often found at positions 16 and 17, but also sometimes at positions 20, 20a, and 20b. hjd 2012-11-16T16:20:37Z biological_process owl:Class
GO:0099042 biolink:NamedThing nucleation of clathrin-coated pit The first step in clathrin-dependent endocytosis: invagination of the plasma membrane to form a pit. got7fsn_ti biological_process owl:Class
GO:0005384 biolink:NamedThing manganese ion transmembrane transporter activity Enables the transfer of manganese (Mn) ions from one side of a membrane to the other. got7fsn_ti Reactome:R-HSA-8959798|RHEA:28699 molecular_function owl:Class
GO:0045960 biolink:NamedThing positive regulation of complement activation, classical pathway Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway. got7fsn_ti activation of complement activation, classical pathway|positive regulation of complement cascade, classical pathway|stimulation of complement activation, classical pathway|upregulation of complement activation, classical pathway|up regulation of complement activation, classical pathway|up-regulation of complement activation, classical pathway biological_process owl:Class
GO:1903948 biolink:NamedThing negative regulation of atrial cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of atrial cardiac muscle cell action potential. got7fsn_ti downregulation of atrial cardiac muscle cell action potential|down-regulation of atrial cardiac muscle cell action potential|down regulation of atrial cardiac muscle cell action potential|inhibition of atrial cardiac muscle cell action potential nc 2015-02-20T14:36:33Z biological_process owl:Class
GO:0001054 biolink:NamedThing RNA polymerase I activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter krc 2010-09-23T03:36:11Z molecular_function owl:Class
GO:0015498 biolink:NamedThing pantothenate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in). got7fsn_ti molecular_function owl:Class
GO:0098719 biolink:NamedThing sodium ion import across plasma membrane The directed movement of sodium ions from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti sodium ion import into cell|sodium import|sodium ion import pr 2012-08-03T16:55:52Z GO:1990118|GO:0097369 biological_process owl:Class
GO:0032834 biolink:NamedThing positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. got7fsn_ti positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response|up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response|stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response|activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0106135 biolink:NamedThing negative regulation of cardiac muscle cell contraction Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell contraction. got7fsn_ti hjd 2018-07-26T16:10:17Z biological_process owl:Class
GO:0035289 biolink:NamedThing posterior head segmentation Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains. got7fsn_ti gnathal segmentation See also the fly_anatomy.ontology term 'gnathal segment ; FBbt:00000011' and its children. biological_process owl:Class
GO:0005950 biolink:NamedThing anthranilate synthase complex A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine. got7fsn_ti cellular_component owl:Class
GO:1903295 biolink:NamedThing negative regulation of glutamate secretion, neurotransmission Any process that stops, prevents or reduces the frequency, rate or extent of glutamate secretion, neurotransmission. got7fsn_ti down regulation of glutamate secretion, neurotransmission|down-regulation of glutamate secretion, neurotransmission|downregulation of glutamate secretion, neurotransmission|inhibition of glutamate secretion, neurotransmission An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype pad 2014-08-13T13:54:23Z biological_process owl:Class
GO:1990411 biolink:NamedThing hercynylcysteine sulfoxide lyase activity (ergothioneine-forming) Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium. got7fsn_ti mah 2014-07-02T15:45:43Z MetaCyc:RXN-14428|RHEA:42688 molecular_function owl:Class
GO:1903028 biolink:NamedThing positive regulation of opsonization Any process that activates or increases the frequency, rate or extent of opsonization. got7fsn_ti up-regulation of opsonization|upregulation of opsonization|activation of opsonization|up regulation of opsonization rl 2014-05-16T17:34:54Z biological_process owl:Class
GO:0046667 biolink:NamedThing compound eye retinal cell programmed cell death Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium. got7fsn_ti biological_process owl:Class
GO:1901683 biolink:NamedThing arsenate ion transmembrane transporter activity Enables the transfer of an arsenate ion from one side of a membrane to the other. got7fsn_ti tb 2012-12-04T23:26:27Z molecular_function owl:Class
GO:1901684 biolink:NamedThing arsenate ion transmembrane transport The process in which arsenate is transported across a membrane. got7fsn_ti Note that this term is not intended for use in annotating lateral movement within membranes. tb 2012-12-04T23:26:36Z biological_process owl:Class
GO:0005548 biolink:NamedThing phospholipid transporter activity Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. got7fsn_ti GO:0008497 Reactome:R-HSA-8865637|Reactome:R-HSA-216757|Reactome:R-HSA-5678749|Reactome:R-HSA-382553|Reactome:R-HSA-8867876|Reactome:R-HSA-8857662|Reactome:R-HSA-5678706 molecular_function owl:Class
GO:0015914 biolink:NamedThing phospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. got7fsn_ti biological_process owl:Class
GO:0031422 biolink:NamedThing RecQ family helicase-topoisomerase III complex A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human. got7fsn_ti RecQ helicase-Topo III complex|Sgs1-Top3 complex cellular_component owl:Class
GO:0090602 biolink:NamedThing sieve element enucleation The process in which nucleated precursor cells lose their nucleus as part of sieve element differentiation. The nuclear contents are released and degraded in the cytoplasm at the same time as other organelles are rearranged and the cytosol is degraded. got7fsn_ti tb 2014-09-05T16:25:16Z biological_process owl:Class
GO:0090603 biolink:NamedThing sieve element differentiation The process whereby a relatively unspecialized cell acquires specialized features of a sieve element. got7fsn_ti tb 2014-09-05T16:38:20Z biological_process owl:Class
GO:0021946 biolink:NamedThing deep nuclear neuron cell migration The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei. got7fsn_ti biological_process owl:Class
GO:0045854 biolink:NamedThing positive regulation of bicoid mRNA localization Any process that activates or increases the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location. got7fsn_ti activation of bicoid mRNA localization|positive regulation of bicoid mRNA localisation|up-regulation of bicoid mRNA localization|upregulation of bicoid mRNA localization|up regulation of bicoid mRNA localization|stimulation of bicoid mRNA localization biological_process owl:Class
GO:0015410 biolink:NamedThing ABC-type manganese transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in). got7fsn_ti ABC-type Mn(2+) transporter|manganese transmembrane transporter activity, phosphorylative mechanism|manganese-transporting ATPase activity|manganese ABC transporter|ATPase-coupled manganese transmembrane transporter activity|ATP-dependent manganese transmembrane transporter activity Reactome:R-HSA-5692462|MetaCyc:3.6.3.35-RXN|RHEA:17365|EC:7.2.2.5 molecular_function owl:Class
GO:0005547 biolink:NamedThing phosphatidylinositol-3,4,5-trisphosphate binding Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. got7fsn_ti PIP3 binding molecular_function owl:Class
GO:0048923 biolink:NamedThing posterior lateral line neuromast hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons. got7fsn_ti biological_process owl:Class
GO:0003842 biolink:NamedThing 1-pyrroline-5-carboxylate dehydrogenase activity Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+). got7fsn_ti 1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity|L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity|pyrroline-5-carboxylic acid dehydrogenase activity|pyrroline-5-carboxylate dehydrogenase activity|1-pyrroline dehydrogenase|delta1-pyrroline-5-carboxylate dehydrogenase activity Reactome:R-HSA-70679|EC:1.2.1.88|MetaCyc:PYRROLINECARBDEHYDROG-RXN|Reactome:R-HSA-6784399|RHEA:16417 molecular_function owl:Class
GO:0008179 biolink:NamedThing adenylate cyclase binding Binding to an adenylate cyclase. got7fsn_ti adenylyl cyclase binding Reactome:R-HSA-170672 molecular_function owl:Class
GO:0047872 biolink:NamedThing dolichol O-acyltransferase activity Catalysis of the reaction: palmitoyl-CoA + dolichol = CoA + dolichyl palmitate. got7fsn_ti acyl-CoA:dolichol acyltransferase activity|palmitoyl-CoA:dolichol O-palmitoyltransferase activity EC:2.3.1.123|RHEA:16685|MetaCyc:DOLICHOL-O-ACYLTRANSFERASE-RXN molecular_function owl:Class
GO:0120146 biolink:NamedThing sulfatide binding Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group. got7fsn_ti sulfated galactocerebroside binding|3-O-sulfogalactosylceramide binding|SM4 binding krc 2018-03-30T20:44:03Z molecular_function owl:Class
GO:0051861 biolink:NamedThing glycolipid binding Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. got7fsn_ti molecular_function owl:Class
GO:0044528 biolink:NamedThing regulation of mitochondrial mRNA stability Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs. got7fsn_ti jl 2012-03-15T03:20:10Z biological_process owl:Class
GO:0098790 biolink:NamedThing ncRNA transcription associated with protein coding gene TSS/TES The transcription of non-coding RNA associated with transcriptional start and end sites of protein coding genes. This occurs at some low level for many protein coding genes. got7fsn_ti pasRNA transcription biological_process owl:Class
GO:0098781 biolink:NamedThing ncRNA transcription The transcription of non (protein) coding RNA from a DNA template. got7fsn_ti biological_process owl:Class
GO:0018637 biolink:NamedThing 1-hydroxy-2-naphthoate hydroxylase activity Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene. got7fsn_ti EC:1.14.13.-|UM-BBD_reactionID:r0491 molecular_function owl:Class
GO:0042778 biolink:NamedThing tRNA end turnover The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA. got7fsn_ti biological_process owl:Class
GO:0071459 biolink:NamedThing protein localization to chromosome, centromeric region Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome. got7fsn_ti protein localization to centromere|protein localisation to chromosome, centromeric region|protein localization to chromosome, centric region mah 2009-12-17T02:11:23Z biological_process owl:Class
GO:0016166 biolink:NamedThing phytoene dehydrogenase activity Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene. got7fsn_ti molecular_function owl:Class
GO:0051118 biolink:NamedThing glucan endo-1,3-alpha-glucosidase activity Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran. got7fsn_ti mutanase activity|1,3(1,3;1,4)-alpha-D-glucan 3-glucanohydrolase activity|endo-1,3-alpha-glucanase activity|endo-1,3-alpha-D-glucanase activity|endo-(1->3)-alpha-glucanase activity|cariogenase activity|cariogenanase activity MetaCyc:3.2.1.59-RXN|EC:3.2.1.59 molecular_function owl:Class
GO:0098836 biolink:NamedThing cytoskeleton of dendritic spine The portion of the cytoskeleton that lies within a dendritic spine. The actin component of this cytoskeleton is involved in spine head remodelling in response to postsynaptic signalling. got7fsn_ti cellular_component owl:Class
GO:0017181 biolink:NamedThing peptidyl-diphthine catabolic process The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue. got7fsn_ti peptidyl-diphthine degradation|peptidyl-diphthine catabolism|peptidyl-diphthine breakdown biological_process owl:Class
GO:0009301 biolink:NamedThing snRNA transcription The synthesis of small nuclear RNA (snRNA) from a DNA template. got7fsn_ti biological_process owl:Class
GO:0018095 biolink:NamedThing protein polyglutamylation The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. got7fsn_ti RESID:AA0202 biological_process owl:Class
GO:0018493 biolink:NamedThing formylmethanofuran dehydrogenase activity Catalysis of the reaction: N-formylmethanofuran + A + H(2)O + H(+) = AH(2) + CO(2) + methanofuran. got7fsn_ti formylmethanofuran:(acceptor) oxidoreductase activity|formylmethanofuran:acceptor oxidoreductase activity MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN|RHEA:19841|EC:1.2.7.12|KEGG_REACTION:R03015|UM-BBD_reactionID:r0345 molecular_function owl:Class
GO:0002638 biolink:NamedThing negative regulation of immunoglobulin production Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production. got7fsn_ti downregulation of immunoglobulin production|negative regulation of immunoglobulin biosynthetic process|negative regulation of immunoglobulin secretion|inhibition of immunoglobulin production|down regulation of immunoglobulin production|down-regulation of immunoglobulin production GO:0002641|GO:0051025 biological_process owl:Class
GO:0051746 biolink:NamedThing thalianol synthase activity Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol). got7fsn_ti EC:5.4.99.31|RHEA:26160 molecular_function owl:Class
GO:0102885 biolink:NamedThing alpha-cuprenene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (-)-alpha-cuprenene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8426|RHEA:32027|EC:4.2.3.95 molecular_function owl:Class
GO:0030342 biolink:NamedThing 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol). got7fsn_ti calcitriol 24-hydroxylase activity|1,25-(OH)2D3 24-hydroxylase activity Reactome:R-HSA-211950|Reactome:R-HSA-209765|Reactome:R-HSA-5602004 molecular_function owl:Class
GO:0071605 biolink:NamedThing monocyte chemotactic protein-1 production The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CCL2 production|MCP-1 production mah 2010-02-05T04:09:53Z biological_process owl:Class
GO:0050068 biolink:NamedThing lysine carbamoyltransferase activity Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H(+) + phosphate. got7fsn_ti lysine transcarbamylase activity|carbamoyl-phosphate:L-lysine carbamoyltransferase activity MetaCyc:LYSINE-CARBAMOYLTRANSFERASE-RXN|EC:2.1.3.8|RHEA:17121|KEGG_REACTION:R01396 molecular_function owl:Class
GO:0055097 biolink:NamedThing high density lipoprotein particle mediated signaling A series of molecular signals mediated by the detection of high density lipoprotein particle. got7fsn_ti high density lipoprotein mediated signalling|high density lipoprotein particle-mediated signaling|high density lipoprotein particle mediated signal transduction biological_process owl:Class
GO:0002235 biolink:NamedThing detection of unfolded protein The series of events in which an unfolded protein stimulus is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0004361 biolink:NamedThing glutaryl-CoA dehydrogenase activity Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor. got7fsn_ti glutaryl coenzyme A dehydrogenase activity|glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)|glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) RHEA:13389|EC:1.3.8.6|MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN|UM-BBD_reactionID:r0198|Reactome:R-HSA-71046 molecular_function owl:Class
GO:0071942 biolink:NamedThing XPC complex A nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair (GG-NER). It is part of the pre-incision (or initial recognition) complex bound to sites of DNA damage. In human, it is composed of XPC, RAD23B and CETN2. got7fsn_ti mah 2010-10-01T11:09:36Z cellular_component owl:Class
GO:0140474 biolink:NamedThing mitochondrion-endoplasmic reticulum membrane tether activity The binding activity of a molecule that brings together a mitochondrion and an ER membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion. got7fsn_ti endoplasmic reticulum-mitochondrion membrane tether activity|mitochondrion-ER membrane adaptor activity|mitochondrion-endoplasmic reticulum membrane adaptor activity|mitochondrion-ER membrane tether activity|ER-mitochondrion membrane tether activity|endoplasmic reticulum-mitochondrion membrane adaptor activity|ER-mitochondrion membrane adaptor activity https://github.com/geneontology/go-ontology/issues/19634 pg 2020-06-22T07:01:14Z molecular_function owl:Class
GO:0010771 biolink:NamedThing negative regulation of cell morphogenesis involved in differentiation Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. got7fsn_ti biological_process owl:Class
GO:0033946 biolink:NamedThing xyloglucan-specific endo-beta-1,4-glucanase activity Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the endohydrolysis of (1->4)-beta-D-glucosidic linkages in xyloglucan. got7fsn_ti xyloglucan endo-beta-1,4-glucanase activity|[(1->6)-beta-D-xylo]-(1->4)-beta-D-glucan glucanohydrolase activity|xyloglucanendohydrolase activity|XH|XEG|xyloglucanase activity|1,4-beta-D-glucan glucanohydrolase activity MetaCyc:3.2.1.151-RXN|EC:3.2.1.151 molecular_function owl:Class
GO:0030379 biolink:NamedThing neurotensin receptor activity, non-G protein-coupled Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins. got7fsn_ti neurotensin receptor activity, non G protein coupled|non G protein coupled neurotensin receptor activity|non-G-protein coupled neurotensin receptor activity|non-G-protein-coupled neurotensin receptor activity|neurotensin receptor activity, non-G-protein coupled molecular_function owl:Class
GO:0034298 biolink:NamedThing arthrospore formation The formation of conidia by the conversion of a pre-existing hypha. An arthrospore is produced by the last cell on a hypha breaking off and dispersing. Usually the walls thicken and the cell(s) separates before swelling of each spore. Sometimes further septa form in each cell prior to disarticulation. got7fsn_ti arthroconidium formation biological_process owl:Class
GO:0046941 biolink:NamedThing azetidine-2-carboxylic acid acetyltransferase activity Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid. got7fsn_ti molecular_function owl:Class
GO:0036145 biolink:NamedThing dendritic cell homeostasis The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti DC homeostasis bf 2012-03-12T11:05:36Z biological_process owl:Class
GO:0010428 biolink:NamedThing methyl-CpNpG binding Binding to a methylated cytosine/unspecified/guanine trinucleotide. got7fsn_ti molecular_function owl:Class
GO:0038046 biolink:NamedThing G protein-coupled enkephalin receptor activity Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body. got7fsn_ti enkephalin receptor activity|delta-opioid receptor activity https://github.com/geneontology/go-ontology/issues/21110 bf 2011-11-14T01:30:14Z molecular_function owl:Class
GO:0070942 biolink:NamedThing neutrophil mediated cytotoxicity The directed killing of a target cell by a neutrophil. got7fsn_ti neutrophil mediated cell killing mah 2009-10-01T01:49:30Z biological_process owl:Class
GO:0032221 biolink:NamedThing Rpd3S/Clr6-CII complex A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species). got7fsn_ti Rpd3C(S)|Clr6-CII|Clr6 histone deacetylase complex II'|Clr6 histone deacetylase complex II|Rpd3S complex|Clr6S complex https://github.com/geneontology/go-ontology/issues/19819 GO:0000509 cellular_component owl:Class
GO:0046507 biolink:NamedThing UDPsulfoquinovose synthase activity Catalysis of the reaction: sulfite + UDP-D-glucose = H(2)O + UDP-6-sulfoquinovose. got7fsn_ti UDPsulphoquinovose synthase activity|UDP-6-sulfo-6-deoxyglucose sulfohydrolase activity|UDP-sulfoquinovose synthase activity|sulfite:UDP-glucose sulfotransferase activity KEGG_REACTION:R05775|RHEA:13197|EC:3.13.1.1|MetaCyc:RXN-1223 molecular_function owl:Class
GO:0140082 biolink:NamedThing SUMO-ubiquitin ligase activity Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin -> Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. got7fsn_ti pg 2017-08-08T14:46:50Z molecular_function owl:Class
GO:0035617 biolink:NamedThing stress granule disassembly The disaggregation of a stress granule into its constituent protein and RNA parts. got7fsn_ti SG disassembly bf 2010-12-03T10:38:57Z biological_process owl:Class
GO:0004796 biolink:NamedThing thromboxane-A synthase activity Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2). got7fsn_ti (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity|(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity|thromboxane synthetase activity|cytochrome P450 CYP5|thromboxane synthase activity GO:0008400 EC:5.3.99.5|Reactome:R-HSA-5603275|RHEA:17137|MetaCyc:THROMBOXANE-A-SYNTHASE-RXN|KEGG_REACTION:R02268|Reactome:R-HSA-76500 molecular_function owl:Class
GO:0021632 biolink:NamedThing optic nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain. got7fsn_ti CN II maturation biological_process owl:Class
GO:0102281 biolink:NamedThing formylaminopyrimidine deformylase activity Catalysis of the reaction: formylaminopyrimidine + H2O <=> 4-amino-5-ammoniomethyl-2-methylpyrimidine + formate. got7fsn_ti MetaCyc:RXN-12612 molecular_function owl:Class
GO:0044288 biolink:NamedThing puncta adhaerentia A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells. got7fsn_ti jl 2010-02-04T02:19:38Z NIF_Subcellular:sao257629430 cellular_component owl:Class
GO:0009731 biolink:NamedThing detection of sucrose stimulus The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of sucrose stimulus biological_process owl:Class
GO:0009744 biolink:NamedThing response to sucrose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus. got7fsn_ti response to sucrose stimulus biological_process owl:Class
GO:0102252 biolink:NamedThing cellulose 1,4-beta-cellobiosidase activity (reducing end) Catalysis of the reaction: n H2O + a cellodextrin = n beta-cellobiose, releasing cellobiose from the reducing ends of the chains. got7fsn_ti EC:3.2.1.176|MetaCyc:RXN-12420 molecular_function owl:Class
GO:1990752 biolink:NamedThing microtubule end Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. got7fsn_ti This term should be used when it is not possible to distinguish between the two microtubule ends, e.g. during image annotation. Whenever possible, please annotate to one of the more specific children GO:0035371 'microtubule plus-end' or GO:0036449 'microtubule minus-end'. pr 2015-05-25T12:50:31Z cellular_component owl:Class
GO:0016034 biolink:NamedThing maleylacetoacetate isomerase activity Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate. got7fsn_ti maleylacetone cis-trans-isomerase activity|maleylacetoacetic isomerase activity|4-maleylacetoacetate cis-trans-isomerase activity|maleylacetone isomerase activity GO:0018841 RHEA:14817|UM-BBD_reactionID:r0106|MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN|Reactome:R-HSA-71173|EC:5.2.1.2 molecular_function owl:Class
GO:1904784 biolink:NamedThing NLRP1 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form a NLRP1 inflammasome complex. got7fsn_ti NALP1 inflammasome complex formation|NLRP1 inflammasome complex formation|NALP1 inflammasome complex assembly https://github.com/geneontology/go-ontology/issues/21092 The aggregation, arrangement and bonding together of a set of components to form the NLRP1 inflammasome complex, occurring at the level of an individual cell. ae 2015-11-02T09:39:44Z biological_process owl:Class
GO:0017023 biolink:NamedThing myosin phosphatase complex An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin. got7fsn_ti cellular_component owl:Class
GO:0008783 biolink:NamedThing agmatinase activity Catalysis of the reaction: agmatine + H(2)O = putrescine + urea. got7fsn_ti agmatine ureohydrolase activity|agmatine amidinohydrolase|SpeB KEGG_REACTION:R01157|EC:3.5.3.11|MetaCyc:AGMATIN-RXN|Reactome:R-HSA-350604|RHEA:13929 molecular_function owl:Class
GO:0047734 biolink:NamedThing CDP-glycerol diphosphatase activity Catalysis of the reaction: CDP-glycerol + H(2)O = sn-glycerol 3-phosphate + CMP + 2 H(+). got7fsn_ti CDPglycerol diphosphatase activity|CDPglycerol phosphoglycerohydrolase activity|CDP-glycerol pyrophosphatase activity|cytidine diphosphoglycerol pyrophosphatase activity|CDPglycerol pyrophosphatase activity|CDP-glycerol phosphoglycerohydrolase activity EC:3.6.1.16|MetaCyc:CDP-GLYCEROL-PYROPHOSPHATASE-RXN|KEGG_REACTION:R00855|RHEA:21692 molecular_function owl:Class
GO:0016362 biolink:NamedThing activin receptor activity, type II Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor. got7fsn_ti type II activin receptor activity Reactome:R-HSA-201443 molecular_function owl:Class
GO:0106243 biolink:NamedThing syn-isopimara-7,15-diene synthase activity Catalysis of the reaction: 9alpha-copalyl diphosphate = diphosphate + syn-isopimara-7,15-diene. got7fsn_ti hjd 2019-12-19T19:04:32Z RHEA:62188 molecular_function owl:Class
GO:0061775 biolink:NamedThing cohesin loading activity Facilitating a conformational change to load a cohesin complex around sister chromatids, driven by ATP hydrolysis. got7fsn_ti cohesin loading ATPase|cohesin ATPase activity|ATP-dependent cohesin loading activity https://github.com/geneontology/go-ontology/issues/14205|https://github.com/geneontology/go-ontology/issues/21700 dph 2016-07-13T12:54:43Z molecular_function owl:Class
GO:0014707 biolink:NamedThing branchiomeric skeletal muscle development The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish. got7fsn_ti biological_process owl:Class
GO:0102146 biolink:NamedThing tricetin O-methytransferase activity Catalysis of the reaction: tricetin + S-adenosyl-L-methionine = H+ + 3'-O-methyltricetin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-11582|RHEA:27493 molecular_function owl:Class
GO:0001602 biolink:NamedThing pancreatic polypeptide receptor activity Combining with pancreatic polypeptide PP to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0004983 biolink:NamedThing neuropeptide Y receptor activity Combining with neuropeptide Y to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0098863 biolink:NamedThing nuclear migration by microtubule mediated pushing forces The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules. got7fsn_ti biological_process owl:Class
GO:0099098 biolink:NamedThing microtubule polymerization based movement The movement of a cellular component as a result of microtubule polymerization. got7fsn_ti biological_process owl:Class
GO:0102944 biolink:NamedThing medicagenate UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + medicagenate <=> UDP(3-) + a medicagenate monoglucoside. got7fsn_ti MetaCyc:RXN-9035 molecular_function owl:Class
GO:0150090 biolink:NamedThing multiple spine synapse organization, single dendrite A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite. got7fsn_ti bc 2018-08-08T14:59:49Z biological_process owl:Class
GO:1900555 biolink:NamedThing emericellamide metabolic process The chemical reactions and pathways involving emericellamide. got7fsn_ti emericellamide metabolism di 2012-05-15T01:32:19Z biological_process owl:Class
GO:1990062 biolink:NamedThing RPAP3/R2TP/prefoldin-like complex A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. got7fsn_ti R2TP/prefoldin-like complex pr 2013-03-20T15:31:12Z cellular_component owl:Class
GO:0097318 biolink:NamedThing invasive growth in response to abiotic stimulus The growth of colonies in filamentous chains of cells as a result of a abiotic stimulus. An example of this process is found in Candida albicans. got7fsn_ti pr 2012-05-31T10:39:31Z biological_process owl:Class
GO:0047102 biolink:NamedThing aminomuconate-semialdehyde dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + 2-aminomuconate semialdehyde = NADH + 2-amino-muconate. got7fsn_ti 2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase activity|alpha-aminomuconic epsilon-semialdehyde dehydrogenase activity|2-hydroxymuconate semialdehyde dehydrogenase activity|2-hydroxymuconic acid semialdehyde dehydrogenase activity|alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity|2-hydroxymuconic semialdehyde dehydrogenase activity|2-aminomuconate semialdehyde dehydrogenase activity MetaCyc:1.2.1.32-RXN|Reactome:R-HSA-71239|EC:1.2.1.32|UM-BBD_reactionID:r1434|RHEA:14469 molecular_function owl:Class
GO:0008924 biolink:NamedThing malate dehydrogenase (quinone) activity Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol. got7fsn_ti (S)-malate:quinone oxidoreductase activity|FAD-dependent malate dehydrogenase activity|(S)-malate:(quinone) oxidoreductase activity|MQO activity RHEA:22556|EC:1.1.5.4|MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN molecular_function owl:Class
GO:0005131 biolink:NamedThing growth hormone receptor binding Binding to a growth hormone receptor. got7fsn_ti growth hormone receptor ligand|growth hormone molecular_function owl:Class
GO:0018772 biolink:NamedThing trioxoheptanoate hydrolase activity Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate. got7fsn_ti MetaCyc:R306-RXN|UM-BBD_reactionID:r0094 molecular_function owl:Class
GO:0034711 biolink:NamedThing inhibin binding Binding to an inhibin monomer, any of the polypeptides that combine to form activin and inhibin dimers. got7fsn_ti inhibin beta-B binding|inhibin beta-A binding|inhibin alpha binding|inhibin monomer binding GO:0034712|GO:0048186|GO:0048187 molecular_function owl:Class
GO:0044616 biolink:NamedThing modulation of relaxation of muscle in other organism The process in which an organism effects a change in the relaxation of muscle in a second organism. got7fsn_ti regulation of relaxation of muscle in other organism jl 2012-07-04T01:54:12Z biological_process owl:Class
GO:1901077 biolink:NamedThing regulation of relaxation of muscle Any process that modulates the frequency, rate or extent of relaxation of muscle. got7fsn_ti jl 2012-07-04T10:44:30Z biological_process owl:Class
GO:0018975 biolink:NamedThing anaerobic 2,4,6-trinitrotoluene metabolic process The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen. got7fsn_ti anaerobic 2,4,6-trinitrotoluene metabolism UM-BBD_pathwayID:tnt2 biological_process owl:Class
GO:0018974 biolink:NamedThing 2,4,6-trinitrotoluene metabolic process The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives. got7fsn_ti TNT metabolic process|2,4,6-trinitrotoluene metabolism|TNT metabolism biological_process owl:Class
GO:0060646 biolink:NamedThing internal mammary gland bud epithelial cell differentiation The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an internal epithelial cell of the mammary gland bud. Internal cells are small and of irregular shape. got7fsn_ti dph 2009-05-29T08:10:48Z biological_process owl:Class
GO:0035611 biolink:NamedThing protein branching point deglutamylation The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue. got7fsn_ti bf 2010-11-18T01:11:21Z biological_process owl:Class
GO:0051673 biolink:NamedThing membrane disruption in other organism The disruption of the membranes of another organism, leading to damage to its cells and possibly death of that organism. got7fsn_ti membrane disruption in another organism|cytolysis, by membrane disruption, in other organism biological_process owl:Class
GO:0045107 biolink:NamedThing intermediate filament polymerization Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain. got7fsn_ti biological_process owl:Class
GO:0044194 biolink:NamedThing cytolytic granule A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells. got7fsn_ti jl 2009-10-20T01:22:13Z cellular_component owl:Class
GO:0045243 biolink:NamedThing cytosolic isocitrate dehydrogenase complex (NAD+) Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity. got7fsn_ti isocitrate dehydrogenase complex (NAD+) cellular_component owl:Class
GO:0018458 biolink:NamedThing isopiperitenol dehydrogenase activity Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH. got7fsn_ti (-)-trans-isopiperitenol:NAD+ oxidoreductase activity RHEA:20860|EC:1.1.1.223|KEGG_REACTION:R03261|UM-BBD_reactionID:r0740|MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0046394 biolink:NamedThing carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. got7fsn_ti carboxylic acid biosynthesis|carboxylic acid formation|carboxylic acid anabolism|carboxylic acid synthesis biological_process owl:Class
GO:0006422 biolink:NamedThing aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA. got7fsn_ti biological_process owl:Class
GO:0017146 biolink:NamedThing NMDA selective glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD. got7fsn_ti NMDA-selective glutamate receptor|N-methyl-D-aspartate selective glutamate receptor complex cellular_component owl:Class
GO:0008786 biolink:NamedThing allose 6-phosphate isomerase activity Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate. got7fsn_ti RHEA:28430|MetaCyc:RXN0-303 molecular_function owl:Class
GO:0016655 biolink:NamedThing oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. got7fsn_ti oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor EC:1.6.5.- molecular_function owl:Class
GO:0061453 biolink:NamedThing interstitial cell of Cajal differentiation The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction. got7fsn_ti ICC differentiation dph 2012-07-20T08:20:50Z biological_process owl:Class
GO:0009002 biolink:NamedThing serine-type D-Ala-D-Ala carboxypeptidase activity Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. got7fsn_ti D-alanyl-D-alanine-cleaving-peptidase activity|D-alanine carboxypeptidase|D-alanyl carboxypeptidase activity|DD-transpeptidase activity|D-alanyl-D-alanine-cleaving peptidase activity|DD-peptidase activity|DD-carboxypeptidase|D-alanyl-D-alanine-carboxypeptidase activity|D-alanyl-D-alanine carboxypeptidase activity EC:3.4.16.4|MetaCyc:3.4.16.4-RXN molecular_function owl:Class
GO:0005237 biolink:NamedThing inhibitory extracellular ligand-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels. got7fsn_ti molecular_function owl:Class
GO:0106357 biolink:NamedThing glycerol-1-phosphate dehydrogenase [NAD+] activity Catalysis of the reaction: NAD+ + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H+ + NADH. got7fsn_ti hjd 2021-02-02T06:07:55Z RHEA:21412 molecular_function owl:Class
GO:1990088 biolink:NamedThing [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase activity Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]. got7fsn_ti hjd 2013-05-06T15:07:20Z EC:2.1.1.246|RHEA:45208 molecular_function owl:Class
GO:0061047 biolink:NamedThing positive regulation of branching involved in lung morphogenesis Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units. got7fsn_ti dph 2010-02-25T10:50:01Z biological_process owl:Class
GO:0048836 biolink:NamedThing specification of increased petal number Any process that increases the number of petals produced in a developing flower. got7fsn_ti biological_process owl:Class
GO:0016516 biolink:NamedThing interleukin-4 receptor complex A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor. got7fsn_ti IL-4 receptor complex cellular_component owl:Class
GO:0035304 biolink:NamedThing regulation of protein dephosphorylation Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein. got7fsn_ti regulation of protein amino acid dephosphorylation biological_process owl:Class
GO:0102055 biolink:NamedThing 12-hydroxyjasmonate sulfotransferase activity Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + a 12-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + a 12-hydroxyjasmonate sulfate. got7fsn_ti EC:2.8.2.39|MetaCyc:RXN-10451|RHEA:52728 molecular_function owl:Class
GO:0018793 biolink:NamedThing 3,5-dibromo-4-hydroxybenzoate decarboxylase activity Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol. got7fsn_ti UM-BBD_reactionID:r0546 molecular_function owl:Class
GO:0097466 biolink:NamedThing ubiquitin-dependent glycoprotein ERAD pathway An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component. got7fsn_ti ER-associated glycoprotein degradation|glycoprotein ERAD|misfolded or incompletely synthesized glycoprotein catabolic process|gpERAD pr 2013-02-05T16:37:13Z biological_process owl:Class
GO:0002348 biolink:NamedThing central B cell positive selection Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors. got7fsn_ti central B-cell positive selection|central B lymphocyte positive selection|central B-lymphocyte positive selection biological_process owl:Class
GO:0046967 biolink:NamedThing cytosol to endoplasmic reticulum transport The directed movement of substances from the cytosol to the endoplasmic reticulum of a cell. got7fsn_ti cytosol to endoplasmic reticulum transport|cytosol to ER transport biological_process owl:Class
GO:0010479 biolink:NamedThing stele development The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds. got7fsn_ti biological_process owl:Class
GO:0070712 biolink:NamedThing RNA cytidine-uridine insertion The modification of an RNA molecule by insertion of an cytidine-uridine dinucleotide. got7fsn_ti RNA CU insertion mah 2009-06-08T05:27:01Z biological_process owl:Class
GO:0070367 biolink:NamedThing negative regulation of hepatocyte differentiation Any process that stops or decreases the rate or extent of hepatocyte differentiation. got7fsn_ti inhibition of hepatocyte differentiation|negative regulation of liver cell differentiation|downregulation of hepatocyte differentiation|down regulation of hepatocyte differentiation|down-regulation of hepatocyte differentiation biological_process owl:Class
GO:0102234 biolink:NamedThing but-1-en-3-one reductase activity Catalysis of the reaction: buten-2-one + NADPH + H+ <=> butan-2-one + NADP. got7fsn_ti MetaCyc:RXN-12293 molecular_function owl:Class
GO:0060476 biolink:NamedThing protein localization involved in acrosome reaction The actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction. got7fsn_ti protein localisation involved in acrosome reaction biological_process owl:Class
GO:0047604 biolink:NamedThing acetoin racemase activity Catalysis of the reaction: (S)-acetoin = (R)-acetoin. got7fsn_ti acetylmethylcarbinol racemase activity KEGG_REACTION:R02949|RHEA:12092|EC:5.1.2.4|MetaCyc:ACETOIN-RACEMASE-RXN molecular_function owl:Class
GO:0005925 biolink:NamedThing focal adhesion A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). got7fsn_ti HAJ|connecting hemi-adherens junction|hemi-adherens junction|adhesion plaque|focal contact GO:0008357|GO:0005926 Wikipedia:Focal_adhesion cellular_component owl:Class
GO:0052810 biolink:NamedThing 1-phosphatidylinositol-5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+). got7fsn_ti ATP:1-phosphatidyl-1D-myo-inositol 5-phosphotransferase activity|1-phosphatidylinositol 5-kinase activity ai 2011-10-21T03:37:20Z Reactome:R-HSA-1675810|Reactome:R-HSA-1675866|RHEA:44680 molecular_function owl:Class
GO:0046265 biolink:NamedThing thiocyanate catabolic process The chemical reactions and pathways resulting in the breakdown of thiocyanate, any anion of thiocyanic acid. got7fsn_ti thiocyanate breakdown|thiocyanate catabolism|thiocyanate degradation biological_process owl:Class
GO:0047415 biolink:NamedThing D-benzoylarginine-4-nitroanilide amidase activity Catalysis of the reaction: N(2)-benzoyl-D-arginine-4-nitroanilide + H(2)O = 4-nitroaniline + N(2)-benzoyl-D-arginine + H(+). got7fsn_ti D-BAPA-ase activity|N-benzoyl-D-arginine-4-nitroanilide amidohydrolase activity|benzoyl-D-arginine arylamidase activity KEGG_REACTION:R04113|RHEA:14421|MetaCyc:3.5.1.72-RXN|EC:3.5.1.72 molecular_function owl:Class
GO:0018564 biolink:NamedThing carbazole 1,9a-dioxygenase activity Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol. got7fsn_ti carbazole 1,9alpha-dioxygenase activity EC:1.13.11.-|UM-BBD_reactionID:r0456 molecular_function owl:Class
GO:0075505 biolink:NamedThing entry of intact viral capsid into host nucleus through nuclear pore complex Viral penetration into the host nucleus where a viral capsid passes intact through the host nuclear pore complex (NPC). got7fsn_ti This mechanism is used by viruses with capsids small enough to cross the nuclear pore complex, such as the single-stranded (ss) DNA viruses Parvoviridae, Circoviridae and Geminiviridae. jl 2011-07-26T04:35:03Z biological_process owl:Class
GO:0075732 biolink:NamedThing viral penetration into host nucleus The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid. got7fsn_ti viral import into host nucleus|viral entry into host nucleus jl 2009-05-01T02:43:16Z VZ:989 biological_process owl:Class
GO:0047794 biolink:NamedThing cyclohexadienyl dehydrogenase activity Catalysis of the reaction: L-arogenate + NAD+ = L-tyrosine + NADH + CO2. got7fsn_ti L-arogenate:NAD+ oxidoreductase activity|arogenic dehydrogenase activity|L-arogenate:NAD+ oxidoreductase (decarboxylating)|L-arogenate:NAD(+) oxidoreductase activity|arogenate dehydrogenase activity|pretyrosine dehydrogenase activity RHEA:12256|EC:1.3.1.43|MetaCyc:CYCLOHEXADIENYL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0033410 biolink:NamedThing UAC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UAC codon. got7fsn_ti tyrosine tRNA|TAC codon-amino acid adaptor activity Note that in the standard genetic code, TAC codes for tyrosine. molecular_function owl:Class
GO:0002940 biolink:NamedThing tRNA N2-guanine methylation The process whereby a guanine in a tRNA is methylated at the N2 position of guanine. got7fsn_ti tRNA m2-guanine biosynthesis hjd 2012-11-09T16:23:41Z biological_process owl:Class
GO:0042300 biolink:NamedThing beta-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin. got7fsn_ti oxidosqualene:beta-amyrin cyclase activity MetaCyc:RXN-7570|EC:5.4.99.- molecular_function owl:Class
GO:0097494 biolink:NamedThing regulation of vesicle size Any process that modulates the size of a vesicle. got7fsn_ti pr 2013-08-06T11:48:51Z biological_process owl:Class
GO:0032141 biolink:NamedThing single cytosine insertion binding Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine. got7fsn_ti molecular_function owl:Class
GO:0072518 biolink:NamedThing Rho-dependent protein serine/threonine kinase activity Rho GTPase-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. got7fsn_ti ROCK kinase activity|Rho-associated protein kinase activity This reaction requires binding of the GTPase Rho. mah 2010-12-22T11:07:29Z molecular_function owl:Class
GO:0008234 biolink:NamedThing cysteine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. got7fsn_ti cysteine protease activity|thiol protease activity GO:0004220 Reactome:R-HSA-2022381|Reactome:R-HSA-5660752|Reactome:R-HSA-2467775|Reactome:R-HSA-2467809 molecular_function owl:Class
GO:0102106 biolink:NamedThing curcumin synthase activity Catalysis of the reaction: feruloylacetyl-CoA + feruloyl-CoA(4-) + H2O <=> curcumin + 2 coenzyme A(4-) + carbon dioxide. got7fsn_ti MetaCyc:RXN-11226|EC:2.3.1.217|RHEA:34823 molecular_function owl:Class
GO:0050331 biolink:NamedThing thiamine-diphosphate kinase activity Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate. got7fsn_ti thiamin diphosphate kinase activity|ATP:thiamin-diphosphate phosphotransferase activity|thiamin diphosphate phosphotransferase activity|ATP:thiamine-diphosphate phosphotransferase activity|thiamin pyrophosphate kinase activity|protein bound thiamin diphosphate:ATP phosphoryltransferase activity|thiamin-diphosphate kinase activity|thiamine diphosphate kinase activity|TDP kinase activity EC:2.7.4.15|RHEA:11240|Reactome:R-HSA-997381|MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN molecular_function owl:Class
GO:0051566 biolink:NamedThing anthocyanidin-3-glucoside rhamnosyltransferase activity Catalysis of the reaction: anthocyanidin 3-glucoside + UDP-rhamnose = anthocyanidin 3-rutinoside + UDP. got7fsn_ti anthocyanidin 3-glucoside-rhamnosyltransferase activity|3RT activity molecular_function owl:Class
GO:0010630 biolink:NamedThing regulation of transcription, start site selection Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template. got7fsn_ti biological_process owl:Class
GO:0019219 biolink:NamedThing regulation of nucleobase-containing compound metabolic process Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. got7fsn_ti regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism biological_process owl:Class
GO:0034779 biolink:NamedThing 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA hydrolase activity Catalysis of the reaction: 4-isopropenyl-2-ketocyclohexane-1-carboxyl-CoA + H2O = 3-isopropenylpimelyl-CoA. got7fsn_ti UM-BBD_reactionID:r1004 molecular_function owl:Class
GO:0070442 biolink:NamedThing integrin alphaIIb-beta3 complex An integrin complex that comprises one alphaIIb subunit and one beta3 subunit. got7fsn_ti alphaIIb-beta3 integrin complex|ITGA2B-ITGB3 complex cellular_component owl:Class
GO:0071354 biolink:NamedThing cellular response to interleukin-6 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus. got7fsn_ti cellular response to IL-6 mah 2009-12-11T02:51:14Z biological_process owl:Class
GO:0050043 biolink:NamedThing lactate racemase activity Catalysis of the reaction: (S)-lactate = (R)-lactate. got7fsn_ti hydroxyacid racemase activity|lacticoracemase activity|lactic acid racemase activity RHEA:10960|EC:5.1.2.1|MetaCyc:LACTATE-RACEMASE-RXN|KEGG_REACTION:R01450 molecular_function owl:Class
GO:0015279 biolink:NamedThing store-operated calcium channel activity A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. got7fsn_ti Reactome:R-HSA-434798 molecular_function owl:Class
GO:0043158 biolink:NamedThing heterocyst differentiation The process in which a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen. got7fsn_ti heterocyst biosynthesis|heterocyst formation|heterocyst cell differentiation biological_process owl:Class
GO:0022007 biolink:NamedThing convergent extension involved in neural plate elongation The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate. got7fsn_ti biological_process owl:Class
GO:0102293 biolink:NamedThing pheophytinase b activity Catalysis of the reaction: pheophytin b + H2O <=> H+ + pheophorbide b + phytol. got7fsn_ti MetaCyc:RXN-12686|EC:3.1.1.14 molecular_function owl:Class
GO:0120218 biolink:NamedThing host interaction involved in quorum sensing A quorum sensing process that is modulated by some interaction with a host cell or organism. got7fsn_ti krc 2019-11-01T21:52:08Z biological_process owl:Class
GO:0033397 biolink:NamedThing zeatin metabolic process The chemical reactions and pathways involving zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. got7fsn_ti zeatin metabolism biological_process owl:Class
GO:0047027 biolink:NamedThing benzyl-2-methyl-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH. got7fsn_ti benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity|benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity EC:1.1.1.217|RHEA:16405|KEGG_REACTION:R04370|MetaCyc:1.1.1.217-RXN molecular_function owl:Class
GO:0046537 biolink:NamedThing 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D glycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate. got7fsn_ti PGAM-i molecular_function owl:Class
GO:0030881 biolink:NamedThing beta-2-microglobulin binding Binding to beta-2-microglobulin. got7fsn_ti molecular_function owl:Class
GO:0042730 biolink:NamedThing fibrinolysis A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin. got7fsn_ti Wikipedia:Fibrinolysis biological_process owl:Class
GO:0034922 biolink:NamedThing 4,5-dihydroxypyrene dioxygenase activity Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0936 molecular_function owl:Class
GO:0090254 biolink:NamedThing cell elongation involved in imaginal disc-derived wing morphogenesis The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis. got7fsn_ti tb 2010-01-22T11:40:46Z biological_process owl:Class
GO:0075055 biolink:NamedThing positive regulation of penetration peg formation Any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration peg formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation of symbiont penetration peg formation for entry into host|positive regulation of symbiont penetration peg initiation https://github.com/geneontology/go-ontology/issues/18557 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. GO:0075059 biological_process owl:Class
GO:0120259 biolink:NamedThing 7SK snRNP A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb. got7fsn_ti snRNP 7SK https://github.com/geneontology/go-ontology/issues/19981 krc 2020-09-15T22:01:31Z cellular_component owl:Class
GO:0050384 biolink:NamedThing urate-ribonucleotide phosphorylase activity Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H(+) + urate. got7fsn_ti UAR phosphorylase activity|urate-ribonucleotide:phosphate D-ribosyltransferase activity|urate-ribonucleotide:phosphate alpha-D-ribosyltransferase activity RHEA:13909|EC:2.4.2.16|MetaCyc:URATE-RIBONUCLEOTIDE-PHOSPHORYLASE-RXN|KEGG_REACTION:R02646 molecular_function owl:Class
GO:0047667 biolink:NamedThing AMP-thymidine kinase activity Catalysis of the reaction: AMP + thymidine = adenosine + thymidine 5'-phosphate. got7fsn_ti adenylic acid:deoxythymidine 5'-phosphotransferase activity|thymidine phosphotransferase activity|AMP:thymidine 5'-phosphotransferase activity|AMP:deoxythymidine kinase activity|AMP:deoxythymidine 5'-phosphotransferase activity|AMP:dThd kinase activity|adenylate-nucleoside phosphotransferase activity MetaCyc:AMP--THYMIDINE-KINASE-RXN|RHEA:14913|EC:2.7.1.114 molecular_function owl:Class
GO:0016601 biolink:NamedThing Rac protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state. got7fsn_ti Rac mediated signal transduction biological_process owl:Class
GO:0098532 biolink:NamedThing histone H3-K27 trimethylation The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone. got7fsn_ti dos 2013-10-18T14:11:17Z biological_process owl:Class
GO:0008288 biolink:NamedThing boss receptor activity Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. got7fsn_ti sevenless receptor activity molecular_function owl:Class
GO:0035315 biolink:NamedThing hair cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a hair cell. got7fsn_ti biological_process owl:Class
GO:0018499 biolink:NamedThing cis-2,3-dihydrodiol DDT dehydrogenase activity Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT. got7fsn_ti UM-BBD_reactionID:r0451 molecular_function owl:Class
GO:0047986 biolink:NamedThing hydrogen-sulfide S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate. got7fsn_ti hydrogen-sulphide S-acetyltransferase activity|hydrogen-sulfide acetyltransferase activity|acetyl-CoA:hydrogen-sulfide S-acetyltransferase activity RHEA:16625|EC:2.3.1.10|KEGG_REACTION:R01850|MetaCyc:HYDROGEN-SULFIDE-S-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:0102580 biolink:NamedThing cyanidin 3-O-glucoside 2-O''-xylosyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + UDP-alpha-D-xylose <=> cyanidin 3-O-beta-D-sambubioside + UDP. got7fsn_ti EC:2.4.2.51|MetaCyc:RXN-15326|RHEA:35443 molecular_function owl:Class
GO:0016042 biolink:NamedThing lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. got7fsn_ti multicellular organism lipid catabolic process|multicellular organismal lipid catabolic process|lipid degradation|lipid breakdown|lipid catabolism|lipolysis GO:0006724|GO:0044240 Wikipedia:Lipid_catabolism biological_process owl:Class
GO:0022893 biolink:NamedThing low-affinity tryptophan transmembrane transporter activity Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low-affinity tryptophan permease activity GO:0015510 molecular_function owl:Class
GO:0060710 biolink:NamedThing chorio-allantoic fusion The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois. got7fsn_ti dph 2009-06-09T03:24:27Z biological_process owl:Class
GO:0102999 biolink:NamedThing UDP-glucose:2-hydroxylamino-4,6-dinitrotoluene-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 2-hydroxylamino-4,6-dinitrotoluene <=> 2-hydroxylamino-4,6-dinitrotoluene-O-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-9743 molecular_function owl:Class
GO:0051038 biolink:NamedThing negative regulation of transcription involved in meiotic cell cycle Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle. got7fsn_ti inhibition of transcription during meiosis|down-regulation of transcription during meiosis|negative regulation of meiotic transcription|meiotic repression of transcription|downregulation of transcription during meiosis|down regulation of transcription during meiosis|negative regulation of transcription, meiotic biological_process owl:Class
GO:0070038 biolink:NamedThing rRNA (pseudouridine-N3-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N3-methylpseudouridine. got7fsn_ti molecular_function owl:Class
GO:0098038 biolink:NamedThing non-replicative transposition, DNA-mediated Process by which a transposable element is excised from the donor site and integrated at the target site without replication of the element. Also referred to as cut-and-paste transposition. got7fsn_ti cut-and-paste transposition bm 2012-07-20T16:47:50Z biological_process owl:Class
GO:0039620 biolink:NamedThing T=7 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres. got7fsn_ti Spherical viruses with T numbers greater than or equal to 7 are skewed. They are therefore described as either right-handed (dextro) or left-handed (laevo). bf 2012-07-18T02:16:40Z VZ:804 cellular_component owl:Class
GO:0110035 biolink:NamedThing rDNA spacer replication fork barrier binding, bending The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. got7fsn_ti kmv 2017-07-17T21:09:50Z molecular_function owl:Class
GO:0070753 biolink:NamedThing interleukin-35 production The appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-35 secretion|interleukin-35 biosynthetic process|IL-35 production mah 2009-06-23T01:25:11Z GO:0070749|GO:0072626 biological_process owl:Class
GO:0050494 biolink:NamedThing GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GSI anchor formation via N-glycyl-glycosylsphingolipidinositolethanolamine|GSI anchor synthesis via N-glycyl-glycosylsphingolipidinositolethanolamine|GSI anchor anabolism via N-glycyl-glycosylsphingolipidinositolethanolamine RESID:AA0165 biological_process owl:Class
GO:0034009 biolink:NamedThing isoprene synthase activity Catalysis of the reaction: dimethylallyl diphosphate = diphosphate + isoprene. got7fsn_ti ISPC|ISPS|dimethylallyl-diphosphate diphosphate-lyase (isoprene-forming) activity EC:4.2.3.27|KEGG_REACTION:R08199|MetaCyc:4.2.3.27-RXN|RHEA:13369 molecular_function owl:Class
GO:0140492 biolink:NamedThing metal-dependent deubiquitinase activity Catalysis of the metal-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin. got7fsn_ti metal-dependent ubiquitinyl-like hydrolase activity|metal-dependent ubiquitin-like hydrolase activity https://github.com/geneontology/go-ontology/issues/17398 pg 2020-07-01T13:14:00Z molecular_function owl:Class
GO:1990926 biolink:NamedThing short-term synaptic potentiation The process by which synaptic transmission, induced by the arrival of a spike (action potential) at a synapse, acts to increase the amount of neurotransmitter released in response to the arrival of subsequent spikes. This effect is seen when a train of closely space spikes arrives at a synapse with a low initial release probability. It occurs in a timeframe of tens to hundreds of milliseconds. got7fsn_ti synaptic facilitation The mechanism of short term potentiation is thought to be either increased influx of calcium into the presynapse (Zucker and Regeh, 2002 PMID:11826273) increased sensitivity to calcium (Jackman et al., 2016 PMID:26738595) or both. sp 2016-02-12T13:17:18Z biological_process owl:Class
GO:0047929 biolink:NamedThing gluconate dehydratase activity Catalysis of the reaction: D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. got7fsn_ti D-gluconate dehydratase activity|D-gluconate hydro-lyase activity|D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming) MetaCyc:GLUCONATE-DEHYDRATASE-RXN|RHEA:21612|EC:4.2.1.39|KEGG_REACTION:R01538 molecular_function owl:Class
GO:0035319 biolink:NamedThing imaginal disc-derived wing hair elongation Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles. got7fsn_ti wing hair elongation|wing prehair extension biological_process owl:Class
GO:0052322 biolink:NamedThing positive regulation of phytoalexin biosynthetic process Any process that activates, maintains or increases the frequency, rate or extent of phytoalexin biosynthesis, the chemical reactions and pathways resulting in the formation of phytoalexins. got7fsn_ti upregulation of phytoalexin biosynthesis|activation of phytoalexin biosynthesis|up-regulation of phytoalexin biosynthesis|up regulation of phytoalexin biosynthesis|positive regulation of phytoalexin biosynthesis|stimulation of phytoalexin biosynthesis biological_process owl:Class
GO:0051749 biolink:NamedThing indole acetic acid carboxyl methyltransferase activity Catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine. got7fsn_ti IAA carboxyl methyltransferase activity molecular_function owl:Class
GO:0052659 biolink:NamedThing inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. got7fsn_ti D-myo-inositol (1,3,4,5)-polyphosphate 5-phosphatase activity|5PTase activity|type II inositol polyphosphate 5-phosphatase activity|inositol polyphosphate-5-phosphatase activity|Ins(1,3,4,5)P(4) 5-phosphatase activity|type I inositol-polyphosphate phosphatase activity|Ins(1,3,4,5)P4 5-phosphatase activity Reactome:R-HSA-1855218|RHEA:11392|KEGG_REACTION:R03430|MetaCyc:RXN-8730|EC:3.1.3.56|Reactome:R-HSA-1855213 molecular_function owl:Class
GO:0106347 biolink:NamedThing U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+. got7fsn_ti hjd 2020-12-18T15:11:10Z RHEA:62672 molecular_function owl:Class
GO:0047299 biolink:NamedThing tryptophan-phenylpyruvate transaminase activity Catalysis of the reaction: keto-phenylpyruvate + L-tryptophan = 3-(indol-3-yl)pyruvate + L-phenylalanine. got7fsn_ti L-tryptophan:phenylpyruvate aminotransferase activity|tryptophan--phenylpyruvate aminotransferase activity|tryptophan-phenylpyruvate aminotransferase activity|L-tryptophan-alpha-ketoisocaproate aminotransferase activity KEGG_REACTION:R01376|MetaCyc:2.6.1.28-RXN|RHEA:13741|EC:2.6.1.28 molecular_function owl:Class
GO:0010254 biolink:NamedThing nectary development The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0030288 biolink:NamedThing outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. got7fsn_ti outer membrane bounded periplasmic space|outer membrane-enclosed periplasmic space Wikipedia:Periplasmic_space cellular_component owl:Class
GO:0042597 biolink:NamedThing periplasmic space The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). got7fsn_ti periplasm GO:0005620 cellular_component owl:Class
GO:0043416 biolink:NamedThing regulation of skeletal muscle tissue regeneration Any process that modulates the frequency, rate or extent of skeletal muscle. got7fsn_ti biological_process owl:Class
GO:1900605 biolink:NamedThing tensidol A biosynthetic process The chemical reactions and pathways resulting in the formation of tensidol A. got7fsn_ti tensidol A anabolism|tensidol A synthesis|tensidol A biosynthesis|tensidol A formation di 2012-05-15T06:58:16Z biological_process owl:Class
GO:0004149 biolink:NamedThing dihydrolipoyllysine-residue succinyltransferase activity Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. got7fsn_ti dihydrolipoyl transsuccinylase activity|lipoyl transsuccinylase activity|dihydrolipolyl transsuccinylase activity|succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity|dihydrolipoic transsuccinylase activity|lipoate succinyltransferase (Escherichia coli) activity|succinyl-CoA:dihydrolipoate S-succinyltransferase activity|succinyl-CoA:dihydrolipoamide S-succinyltransferase activity|lipoic transsuccinylase activity|lipoate succinyltransferase activity|enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity|dihydrolipoamide succinyltransferase activity|succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity|dihydrolipoamide S-succinyltransferase activity EC:2.3.1.61|RHEA:15213 molecular_function owl:Class
GO:2000253 biolink:NamedThing positive regulation of feeding behavior Any process that activates or increases the frequency, rate or extent of feeding behavior. got7fsn_ti positive regulation of drinking|positive regulation of behavioural response to food|positive regulation of behavioral response to food|positive regulation of eating|positive regulation of feeding behaviour yaf 2010-11-18T11:24:18Z biological_process owl:Class
GO:0032018 biolink:NamedThing 2-methylbutanol:NADP oxidoreductase activity Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+. got7fsn_ti 2-methylbutyraldehyde reductase (NADP) activity|2-methylbutanal reductase (NADP) activity molecular_function owl:Class
GO:0003389 biolink:NamedThing retrograde extension The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point. got7fsn_ti dph 2009-12-09T09:22:03Z biological_process owl:Class
GO:0070370 biolink:NamedThing cellular heat acclimation Any process that increases heat tolerance of a cell in response to high temperatures. got7fsn_ti cellular thermotolerance biological_process owl:Class
GO:0004063 biolink:NamedThing aryldialkylphosphatase activity Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol. got7fsn_ti organophosphorus acid anhydrase activity|aryltriphosphate dialkylphosphohydrolase activity|pirimiphos-methyloxon esterase activity|esterase E4|paraoxon hydrolase activity|phosphotriesterase activity|A-esterase activity|paraoxonase activity|OPH|aryltriphosphatase activity|organophosphate hydrolase activity|esterase B1|organophosphate esterase activity|organophosphorus hydrolase activity|paraoxon esterase activity RHEA:18053|UM-BBD_enzymeID:e0054|EC:3.1.8.1|MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN molecular_function owl:Class
GO:0043971 biolink:NamedThing histone H3-K18 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone. got7fsn_ti histone H3K18 acetylation|histone H3 acetylation at K18 biological_process owl:Class
GO:0098018 biolink:NamedThing viral capsid, minor subunit The part of the viral capsid that comprises the less common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the pentameric capsomeres are minor subunits. got7fsn_ti minor capsomere|minor head protein bm 2012-07-19T11:28:18Z cellular_component owl:Class
GO:2001141 biolink:NamedThing regulation of RNA biosynthetic process Any process that modulates the frequency, rate or extent of RNA biosynthetic process. got7fsn_ti regulation of RNA anabolism|regulation of RNA biosynthesis|regulation of RNA synthesis|regulation of RNA formation dph 2011-10-17T11:36:25Z biological_process owl:Class
GO:0031819 biolink:NamedThing P2Y10 nucleotide receptor binding Binding to a P2Y10 nucleotide receptor. got7fsn_ti P2Y10 nucleotide receptor ligand molecular_function owl:Class
GO:0018047 biolink:NamedThing C-terminal peptidyl-phenylalanine amidation The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0094 biological_process owl:Class
GO:0045438 biolink:NamedThing delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol. got7fsn_ti ACV synthetase activity molecular_function owl:Class
GO:0018469 biolink:NamedThing myrtenal dehydrogenase activity Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid. got7fsn_ti UM-BBD_reactionID:r0711 molecular_function owl:Class
GO:0006711 biolink:NamedThing estrogen catabolic process The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants. got7fsn_ti estrogen catabolism|estrogen degradation|oestrogen catabolism|oestrogen catabolic process|estrogen breakdown biological_process owl:Class
GO:0004569 biolink:NamedThing glycoprotein endo-alpha-1,2-mannosidase activity Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane. got7fsn_ti endo-alpha-mannosidase activity|endomannosidase activity|glycoprotein glucosylmannohydrolase activity|glucosyl mannosidase activity|glucosylmannosidase activity RHEA:54824|Reactome:R-HSA-964759|MetaCyc:3.2.1.130-RXN|EC:3.2.1.130 molecular_function owl:Class
GO:0071892 biolink:NamedThing thrombocyte activation A cell activation process that occurs in thrombocytes and consists of a series of progressive, overlapping events including shape change, adhesiveness, and aggregation, which, when carried through to completion, lead to the formation of a stable hemostatic plug. Thrombocytes are nucleated cells found in non-mammalian vertebrates and are involved in hemostasis. They are the functional equivalent of the non-nucleated platelets found in mammals. got7fsn_ti blood coagulation, thrombocyte activation mah 2010-09-14T03:06:33Z biological_process owl:Class
GO:0103075 biolink:NamedThing indole-3-pyruvate monooxygenase activity Catalysis of the reaction: 3-(indol-3-yl)pyruvate + NADPH + O2 + H+ <=> indole-3-acetate + carbon dioxide + NADP + H2O. got7fsn_ti MetaCyc:RXNDQC-2|RHEA:34331|EC:1.14.13.168 molecular_function owl:Class
GO:0098744 biolink:NamedThing 1-phosphatidylinositol 4-kinase activator activity Binds to and increases the activity of 1-phosphatidylinositol 4-kinase. got7fsn_ti molecular_function owl:Class
GO:0110064 biolink:NamedThing lncRNA catabolic process The chemical reactions and pathways resulting in the breakdown of lncRNAs, non-coding RNAs over 200 nucleotides in length. got7fsn_ti lncRNA degradation|lncRNA breakdown|lncRNA catabolism kmv 2017-11-06T13:49:49Z biological_process owl:Class
GO:0072185 biolink:NamedThing metanephric cap development The biological process whose specific outcome is the progression of the metanephric cap from an initial condition to its mature state. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. got7fsn_ti mah 2010-03-01T01:20:22Z biological_process owl:Class
GO:0140580 biolink:NamedThing mitochondrion autophagosome adaptor activity The binding activity of a molecule that brings together a mitochondrial membrane and an autophagosome during mitophagy. got7fsn_ti mitophagy receptor https://github.com/geneontology/go-ontology/issues/20668 pg 2021-01-18T11:03:49Z molecular_function owl:Class
GO:0021977 biolink:NamedThing tectospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord. got7fsn_ti biological_process owl:Class
GO:0061896 biolink:NamedThing all-trans retinol 3,4-desaturase activity Catalysis of the reaction: all-trans-retinol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized [adrenodoxin]. got7fsn_ti dph 2017-06-12T14:49:30Z RHEA:50292 molecular_function owl:Class
GO:0090672 biolink:NamedThing telomerase RNA localization Any process in which telomerase RNA is transported to, or maintained in, a specific location. got7fsn_ti tb 2015-12-17T14:08:01Z biological_process owl:Class
GO:0004789 biolink:NamedThing thiamine-phosphate diphosphorylase activity Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate. got7fsn_ti thiamin-phosphate pyrophosphorylase activity|TMP-PPase activity|thiamine-phosphate synthase activity|TMP pyrophosphorylase activity|thiamine phosphate pyrophosphorylase activity|thiamin-phosphate diphosphorylase activity|TMP diphosphorylase activity|thiamine-phosphate pyrophosphorylase activity|thiamine monophosphate pyrophosphorylase activity|2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity RHEA:22328|KEGG_REACTION:R03223|EC:2.5.1.3|MetaCyc:THI-P-SYN-RXN molecular_function owl:Class
GO:0010785 biolink:NamedThing clathrin coating of Golgi vesicle, plasma membrane to endosome targeting The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat. got7fsn_ti biological_process owl:Class
GO:0090037 biolink:NamedThing positive regulation of protein kinase C signaling Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. got7fsn_ti positive regulation of protein kinase C signalling cascade|positive regulation of protein kinase C signaling cascade tb 2009-08-03T11:28:44Z biological_process owl:Class
GO:0106156 biolink:NamedThing peptidyl-lysine 4-dioxygenase activity Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 4-hydroxy-L-lysine + succinate + CO2. got7fsn_ti hjd 2018-11-26T14:59:18Z RHEA:57156 molecular_function owl:Class
GO:1901731 biolink:NamedThing positive regulation of platelet aggregation Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules. got7fsn_ti positive regulation of thrombocyte aggregation|upregulation of thrombocyte aggregation|up regulation of platelet aggregation|up-regulation of thrombocyte aggregation|up-regulation of blood platelet aggregation|activation of blood platelet aggregation|up-regulation of platelet aggregation|activation of platelet aggregation|positive regulation of blood platelet aggregation|up regulation of thrombocyte aggregation|up regulation of blood platelet aggregation|upregulation of platelet aggregation|activation of thrombocyte aggregation|upregulation of blood platelet aggregation pr 2013-01-10T13:25:39Z biological_process owl:Class
GO:0060812 biolink:NamedThing orthodenticle mRNA localization Any process in which orthodenticle mRNA is transported to and maintained in the oocyte and/or syncytial embryo as part of the process that will specify the anterior/posterior axis. got7fsn_ti orthodenticle mRNA localisation dph 2009-08-07T09:39:01Z biological_process owl:Class
GO:0031133 biolink:NamedThing regulation of axon diameter Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained. got7fsn_ti biological_process owl:Class
GO:0050770 biolink:NamedThing regulation of axonogenesis Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. got7fsn_ti biological_process owl:Class
GO:0036435 biolink:NamedThing K48-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein. got7fsn_ti bf 2013-09-18T14:51:06Z Reactome:R-HSA-5683077 molecular_function owl:Class
GO:0018617 biolink:NamedThing 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol. got7fsn_ti 4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity UM-BBD_reactionID:r0580|EC:1.14.12.- molecular_function owl:Class
GO:0090510 biolink:NamedThing anticlinal cell division A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file. got7fsn_ti tb 2012-11-21T11:52:40Z biological_process owl:Class
GO:0000386 biolink:NamedThing second spliceosomal transesterification activity Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. got7fsn_ti lariat formation, 5'-splice site cleavage|3'-splice site cleavage, exon ligation molecular_function owl:Class
GO:0003114 biolink:NamedThing positive regulation of heart rate by circulating norepinephrine The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction. got7fsn_ti positive regulation of heart rate by circulating noradrenaline biological_process owl:Class
GO:0051011 biolink:NamedThing microtubule minus-end binding Binding to the minus end of a microtubule. got7fsn_ti molecular_function owl:Class
GO:0008017 biolink:NamedThing microtubule binding Binding to a microtubule, a filament composed of tubulin monomers. got7fsn_ti microtubule/chromatin interaction|microtubule severing activity Reactome:R-HSA-9614343 molecular_function owl:Class
GO:0098861 biolink:NamedThing actin filament bundle of filopodium A parallel bundle of actin filaments that is part of filopodium. Filaments are oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex. got7fsn_ti cellular_component owl:Class
GO:0008774 biolink:NamedThing acetaldehyde dehydrogenase (acetylating) activity Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+. got7fsn_ti aldehyde dehydrogenase (acylating) activity|acylating acetaldehyde dehydrogenase activity|ADA|DmpF|acetaldehyde:NAD+ oxidoreductase (CoA-acetylating) EC:1.2.1.10|RHEA:23288|MetaCyc:ACETALD-DEHYDROG-RXN molecular_function owl:Class
GO:0019695 biolink:NamedThing choline metabolic process The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. got7fsn_ti choline metabolism biological_process owl:Class
GO:0031987 biolink:NamedThing locomotion involved in locomotory behavior Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement. got7fsn_ti locomotion during locomotory behaviour biological_process owl:Class
GO:0043730 biolink:NamedThing 5-ureido-4-imidazole carboxylate hydrolase activity Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2. got7fsn_ti molecular_function owl:Class
GO:0001195 biolink:NamedThing maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter. got7fsn_ti maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter krc 2011-09-02T02:41:29Z biological_process owl:Class
GO:0098821 biolink:NamedThing BMP receptor activity Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0034837 biolink:NamedThing 2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1179 molecular_function owl:Class
GO:0005835 biolink:NamedThing fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. got7fsn_ti FAS complex|cytosolic type I fatty acid synthase complex|holo-[acyl-carrier-protein] synthase complex|cytosolic fatty acid synthase complex|fatty acid synthetase complex|cytosolic FAS complex|cytosolic type I FAS complex GO:0031373|GO:0031374 Wikipedia:Fatty_acid_synthetase_complex cellular_component owl:Class
GO:0090719 biolink:NamedThing adaptive immune effector response involving T cells and B lineage cells An adaptive immune effector response involving T cells and B lineage cells. In the case of B lineage cells, the effector cells are the antibody secreting plasma cells whereas for T cells the effector cells may be helper T cells or cytotoxic T cells. got7fsn_ti tb 2016-11-11T12:43:26Z biological_process owl:Class
GO:0080085 biolink:NamedThing signal recognition particle, chloroplast targeting A complex consisting of a protein and RNA component which binds the signal sequence of some proteins and facilitates their export to the chloroplast. got7fsn_ti dhl 2009-04-22T02:36:01Z cellular_component owl:Class
GO:0018471 biolink:NamedThing 4-chlorobenzaldehyde oxidase activity Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-. got7fsn_ti EC:1.14.13.-|UM-BBD_reactionID:r0447 molecular_function owl:Class
GO:0030229 biolink:NamedThing very-low-density lipoprotein particle receptor activity Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis. got7fsn_ti VLDL receptor|apolipoprotein E receptor activity|very-low-density lipoprotein receptor activity Wikipedia:VLDL_receptor molecular_function owl:Class
GO:0075720 biolink:NamedThing establishment of episomal latency A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity. got7fsn_ti establishment of plasmid latency|establishment as a plasmid prophage jl 2009-11-26T03:57:44Z biological_process owl:Class
GO:0097109 biolink:NamedThing neuroligin family protein binding Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. got7fsn_ti pr 2011-07-28T05:15:22Z molecular_function owl:Class
GO:0016176 biolink:NamedThing superoxide-generating NADPH oxidase activator activity Increases the activity of the enzyme superoxide-generating NADPH oxidase. got7fsn_ti neutrophil cytosol factor 2 molecular_function owl:Class
GO:0140121 biolink:NamedThing Lewy body formation The aggregation, arrangement and bonding together of a set of components to form a Lewy body. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14160 pg 2017-10-25T06:59:12Z biological_process owl:Class
GO:0090741 biolink:NamedThing pigment granule membrane Any membrane that is part of a pigment granule. got7fsn_ti tb 2017-05-16T22:33:39Z cellular_component owl:Class
GO:0090541 biolink:NamedThing MIT domain binding Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking. got7fsn_ti tb 2013-02-14T17:11:29Z molecular_function owl:Class
GO:0090629 biolink:NamedThing lagging strand initiation The process in which the synthesis of DNA from a template strand in a net 3' to 5' direction is started. got7fsn_ti tb 2015-02-11T14:37:13Z biological_process owl:Class
GO:0003345 biolink:NamedThing proepicardium cell migration involved in pericardium morphogenesis The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart. got7fsn_ti dph 2009-12-01T10:49:32Z biological_process owl:Class
GO:0060973 biolink:NamedThing cell migration involved in heart development The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ. got7fsn_ti dph 2009-10-06T10:53:49Z biological_process owl:Class
GO:0015055 biolink:NamedThing secretin receptor activity Combining with secretin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0047274 biolink:NamedThing galactinol-sucrose galactosyltransferase activity Catalysis of the reaction: sucrose + 1-alpha-D-galactosyl-myo-inositol = raffinose + myo-inositol. got7fsn_ti alpha-D-galactosyl-(1->3)-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity|1-alpha-D-galactosyl-myo-inositol:sucrose 6-alpha-D-galactosyltransferase activity|galactinol:sucrose 6-galactosyl transferase activity|raffinose synthase activity|galactosyltransferase, galactinol-sucrose EC:2.4.1.82|RHEA:20161|MetaCyc:2.4.1.82-RXN molecular_function owl:Class
GO:0018396 biolink:NamedThing peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine. got7fsn_ti RESID:AA0235 biological_process owl:Class
GO:0000906 biolink:NamedThing 6,7-dimethyl-8-ribityllumazine synthase activity Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. got7fsn_ti lumazine synthase activity RHEA:26152|MetaCyc:LUMAZINESYN-RXN|EC:2.5.1.78 molecular_function owl:Class
GO:0090143 biolink:NamedThing nucleoid organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined. got7fsn_ti nucleoid organisation tb 2009-12-08T02:35:48Z biological_process owl:Class
GO:0008873 biolink:NamedThing gluconate 2-dehydrogenase activity Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+. got7fsn_ti 2-keto-D-gluconate reductase activity|2-ketogluconate reductase activity|D-gluconate:NADP+ oxidoreductase activity EC:1.1.1.215|MetaCyc:1.1.1.215-RXN|RHEA:16653 molecular_function owl:Class
GO:0018254 biolink:NamedThing peptidyl-tyrosine adenylylation The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine. got7fsn_ti peptidyl-tyrosine adenylation RESID:AA0203 biological_process owl:Class
GO:0039511 biolink:NamedThing suppression by virus of host interferon receptor activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor. got7fsn_ti inhibition of host interferon receptors by virus|inhibition by virus of host interferon receptor activity|down-regulation by virus of host interferon receptor activity|negative regulation by virus of host interferon receptor activity|downregulation by virus of host interferon receptor activity bf 2011-06-16T02:24:05Z VZ:843 biological_process owl:Class
GO:0098787 biolink:NamedThing mRNA cleavage involved in mRNA processing Cleavage of an immature mRNA transcript to produce one or more more mature mRNA transcripts, prior to translation into polypeptide. got7fsn_ti biological_process owl:Class
GO:0006379 biolink:NamedThing mRNA cleavage Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. got7fsn_ti cleavage stimulation factor activity biological_process owl:Class
GO:0002587 biolink:NamedThing negative regulation of antigen processing and presentation of peptide antigen via MHC class II Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II. got7fsn_ti downregulation of antigen processing and presentation of peptide antigen via MHC class II|down regulation of antigen processing and presentation of peptide antigen via MHC class II|negative regulation of peptide antigen processing and presentation via MHC class II|down-regulation of antigen processing and presentation of peptide antigen via MHC class II|inhibition of antigen processing and presentation of peptide antigen via MHC class II biological_process owl:Class
GO:0052772 biolink:NamedThing brefeldin A esterase activity Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone. got7fsn_ti brefeldin A hydrolase activity|BFA esterase activity ai 2011-10-03T12:01:00Z molecular_function owl:Class
GO:0061002 biolink:NamedThing negative regulation of dendritic spine morphogenesis Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. got7fsn_ti dph 2010-01-20T09:34:49Z biological_process owl:Class
GO:0061000 biolink:NamedThing negative regulation of dendritic spine development Any process that decreases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. got7fsn_ti dph 2010-01-20T09:29:18Z biological_process owl:Class
GO:0070166 biolink:NamedThing enamel mineralization The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel. got7fsn_ti enamel formation biological_process owl:Class
GO:0072563 biolink:NamedThing endothelial microparticle A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell. got7fsn_ti mah 2011-01-28T01:53:25Z cellular_component owl:Class
GO:0043748 biolink:NamedThing O-succinylbenzoate synthase activity Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate. got7fsn_ti EC:4.2.1.113 molecular_function owl:Class
GO:0097513 biolink:NamedThing myosin II filament A bipolar filament composed of myosin II molecules. got7fsn_ti pr 2013-10-16T13:06:20Z cellular_component owl:Class
GO:0090494 biolink:NamedThing dopamine uptake The directed movement of dopamine into a cell. got7fsn_ti tb 2012-10-17T11:12:09Z biological_process owl:Class
GO:0015872 biolink:NamedThing dopamine transport The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. got7fsn_ti biological_process owl:Class
GO:0106299 biolink:NamedThing resolution phase response An active host response phase of acute inflammation driven by specialized pro-resolving mediators (SPMs) and signaling pathways, enabling timely tissue regeneration and return of function. got7fsn_ti Acute inflammatory response(s) are self-limited, resolve on their own and classically divide into initiation and resolution phases. SPMs are a superfamily of proresolving mediators that include resolvins (Rvs), protectins (PDs), maresins (MaRs) and lipoxins (LXs). hjd 2020-08-25T13:54:05Z biological_process owl:Class
GO:0033895 biolink:NamedThing ribonuclease [poly-(U)-specific] activity Catalysis of the endonucleolytic cleavage of poly(U) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. got7fsn_ti uracil-specific RNase activity|ribonuclease (uracil-specific) activity|uracil-specific endoribonuclease activity EC:3.1.26.9 molecular_function owl:Class
GO:0004845 biolink:NamedThing uracil phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil. got7fsn_ti UPRTase activity|UMP pyrophosphorylase activity|uridine monophosphate pyrophosphorylase activity|UMP:diphosphate phospho-alpha-D-ribosyltransferase activity|UMP diphosphorylase activity|uridine 5'-phosphate pyrophosphorylase activity|uridylic pyrophosphorylase activity|uridylate pyrophosphorylase activity|UMP:pyrophosphate phosphoribosyltransferase activity KEGG_REACTION:R00966|MetaCyc:URACIL-PRIBOSYLTRANS-RXN|EC:2.4.2.9|RHEA:13017 molecular_function owl:Class
GO:0106312 biolink:NamedThing methylenetetrahydrofolate reductase NADH activity Catalysis of the reaction: 5-methyltetrahydrofolate + NAD + = 5,10-methylenetetrahydrofolate + NADH + H+. got7fsn_ti hjd 2020-09-23T14:20:07Z RHEA:19821 molecular_function owl:Class
GO:0051911 biolink:NamedThing Methanosarcina-phenazine hydrogenase activity Catalysis of the reaction: H2 + 2-(2,3-dihydropentaprenyloxy)phenazine = 2-dihydropentaprenyloxyphenazine. got7fsn_ti coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity|methylviologen-reducing hydrogenase activity|methanophenazine hydrogenase activity|hydrogen:2-(2,3-dihydropentaprenyloxy)phenazine oxidoreductase activity MetaCyc:RXN-7733|EC:1.12.98.3|RHEA:24436 molecular_function owl:Class
GO:0019639 biolink:NamedThing 6-hydroxycineole catabolic process The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2. got7fsn_ti 6-hydroxycineole breakdown|6-endo-hydroxycineole catabolic process|6-hydroxycineole degradation|6-hydroxycineole catabolism|hydroxycineol catabolic process|6-endo-hydroxycineole catabolism|hydroxycineol catabolism MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY biological_process owl:Class
GO:0033954 biolink:NamedThing alpha-neoagaro-oligosaccharide hydrolase activity Catalysis of the hydrolysis of the 1,3-alpha-L-galactosidic linkages of neoagaro-oligosaccharides that are smaller than a hexamer, yielding 3,6-anhydro-L-galactose and D-galactose. got7fsn_ti alpha-neoagarooligosaccharide hydrolase activity|alpha-NAOS hydrolase activity|alpha-neoagaro-oligosaccharide 3-glycohydrolase activity EC:3.2.1.159|MetaCyc:3.2.1.159-RXN molecular_function owl:Class
GO:0018968 biolink:NamedThing tetrahydrofuran metabolic process The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems. got7fsn_ti THF metabolism|tetrahydrofuran metabolism|THF metabolic process UM-BBD_pathwayID:thf biological_process owl:Class
GO:0018581 biolink:NamedThing hydroxyquinol 1,2-dioxygenase activity Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate. got7fsn_ti hydroxyquinol dioxygenase activity|benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing) EC:1.13.11.37|MetaCyc:HYDROXYQUINOL-12-DIOXYGENASE-RXN|UM-BBD_reactionID:r0232|RHEA:19441 molecular_function owl:Class
GO:0097586 biolink:NamedThing dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p. got7fsn_ti dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer|Pmt4p-Pmt4p complex|dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p-Pmt4p dimer complex pr 2014-03-02T18:19:05Z cellular_component owl:Class
GO:0018972 biolink:NamedThing toluene-4-sulfonate metabolic process The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water. got7fsn_ti toluene-4-sulfonate metabolism|toluene-4-sulphonate metabolic process|4-methylbenzenesulfonate metabolism|4-toluenesulfonate metabolic process|toluene-4-sulphonate metabolism|4-methylbenzenesulfonate metabolic process|4-toluenesulfonate metabolism UM-BBD_pathwayID:tsa|MetaCyc:TOLSULFDEG-PWY biological_process owl:Class
GO:0070998 biolink:NamedThing sensory perception of gravity The series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti mah 2009-11-03T03:25:12Z biological_process owl:Class
GO:0047499 biolink:NamedThing calcium-independent phospholipase A2 activity Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. got7fsn_ti calcium-independent cytosolic phospholipase A2 activity Reactome:R-HSA-8952251 molecular_function owl:Class
GO:0102583 biolink:NamedThing cyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity Catalysis of the reaction: cyanidin 3-O-beta-D-sambubioside + 4-coumaryl-CoA <=> cyanidin 3-O-[2''-O-xylosyl) 6''-O-(p-coumaroyl) glucoside + coenzyme A. got7fsn_ti MetaCyc:RXN-15329 molecular_function owl:Class
GO:0097678 biolink:NamedThing SOCS family protein binding Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions. got7fsn_ti suppressor of cytokine signaling family protein binding pr 2014-11-04T11:32:49Z molecular_function owl:Class
GO:0102824 biolink:NamedThing UDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity Catalysis of the reaction: quercetin-7-olate + UDP-L-rhamnose <=> H+ + quercetin 3-O-rhamnoside + UDP. got7fsn_ti MetaCyc:RXN-8267|RHEA:61160 molecular_function owl:Class
GO:0102549 biolink:NamedThing 1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + H2O <=> sn-1-lyso-2-16:0-monogalactosyldiacylglycerol + oleate + H+. got7fsn_ti EC:3.1.1.26|MetaCyc:RXN-14912 molecular_function owl:Class
GO:0102889 biolink:NamedThing beta-elemene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> beta-elemene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8432 molecular_function owl:Class
GO:0072382 biolink:NamedThing minus-end-directed vesicle transport along microtubule The directed movement of a vesicle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination. got7fsn_ti microtubule minus-end-directed vesicle localization|microtubule minus-end-directed vesicle distribution mah 2010-12-01T04:12:59Z biological_process owl:Class
GO:0072385 biolink:NamedThing minus-end-directed organelle transport along microtubule The directed movement of an organelle towards the minus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination. got7fsn_ti microtubule minus-end-directed organelle distribution|microtubule minus-end-directed organelle localization mah 2010-12-01T05:01:20Z biological_process owl:Class
GO:0050155 biolink:NamedThing ornithine(lysine) transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate. got7fsn_ti lysine/ornithine:2-oxoglutarate aminotransferase activity|L-ornithine(L-lysine):2-oxoglutarate-aminotransferase activity|L-ornithine:2-oxoglutarate-aminotransferase activity|ornithine(lysine) aminotransferase activity MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN|EC:2.6.1.13 molecular_function owl:Class
GO:0031854 biolink:NamedThing orexigenic neuropeptide QRFP receptor binding Binding to an orexigenic neuropeptide QRFP receptor. got7fsn_ti orexigenic neuropeptide QRFP receptor ligand molecular_function owl:Class
GO:0018827 biolink:NamedThing 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU. got7fsn_ti DDMS dehydrochlorinase activity UM-BBD_reactionID:r0515|EC:4.5.1.- molecular_function owl:Class
GO:0033485 biolink:NamedThing cyanidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. got7fsn_ti cyanidin 3-O-glucoside biosynthesis|cyanidin 3-O-glucoside anabolism|cyanidin 3-O-glucoside formation|cyanidin 3-O-glucoside synthesis MetaCyc:PWY-5125 biological_process owl:Class
GO:0030619 biolink:NamedThing U1 snRNA binding Binding to a U1 small nuclear RNA (U1 snRNA). got7fsn_ti Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). molecular_function owl:Class
GO:0051260 biolink:NamedThing protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. got7fsn_ti protein homooligomer biosynthetic process|protein homooligomer assembly|protein homooligomerization activity|protein homooligomer biosynthesis|protein homooligomer formation biological_process owl:Class
GO:0050403 biolink:NamedThing trans-zeatin O-beta-D-glucosyltransferase activity Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H(+) + UDP. got7fsn_ti UDP-glucose:trans-zeatin O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-zeatin O-glucosyltransferase activity|zeatin O-glucosyltransferase activity|zeatin O-beta-D-glucosyltransferase activity|zeatin O-b-D-glucosyltransferase activity|UDPglucose:trans-zeatin O-beta-D-glucosyltransferase activity KEGG_REACTION:R02118|EC:2.4.1.203|RHEA:23224|MetaCyc:RXN-4723 molecular_function owl:Class
GO:0001762 biolink:NamedThing beta-alanine transport The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0051758 biolink:NamedThing homologous chromosome movement towards spindle pole in meiosis I anaphase The directed movement of homologous chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis I anaphase. got7fsn_ti meiosis I, homologous chromosome movement towards spindle pole|homologous chromosome movement towards spindle pole during meiosis I biological_process owl:Class
GO:0047237 biolink:NamedThing glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-1,3-beta-D-galactosylproteoglycan + UDP. got7fsn_ti UDP-N-acetyl-D-galactosamine:D-glucuronyl-1,3-beta-D-galactosyl-proteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-chondroitinacetylgalactosaminyltransferase I activity|N-acetylgalactosaminyltransferase I activity|uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase I|glucuronylgalactosylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase activity MetaCyc:2.4.1.174-RXN|EC:2.4.1.174|RHEA:23464 molecular_function owl:Class
GO:0052812 biolink:NamedThing phosphatidylinositol-3,4-bisphosphate 5-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+). got7fsn_ti ATP:1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 5-phosphotransferase activity ai 2011-10-21T03:52:02Z Reactome:R-HSA-1675773|EC:2.7.1.153 molecular_function owl:Class
GO:0018616 biolink:NamedThing trihydroxytoluene dioxygenase activity Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate. got7fsn_ti MetaCyc:R305-RXN|UM-BBD_reactionID:r0093 molecular_function owl:Class
GO:0048150 biolink:NamedThing behavioral response to ether Any process that results in a change in the behavior of an organism as a result of an ether stimulus. got7fsn_ti behavioural response to ether biological_process owl:Class
GO:0070663 biolink:NamedThing regulation of leukocyte proliferation Any process that modulates the frequency, rate or extent of leukocyte proliferation. got7fsn_ti mah 2009-05-28T05:30:39Z biological_process owl:Class
GO:0080098 biolink:NamedThing L-tyrosine:pyruvate aminotransferase activity Catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine. got7fsn_ti dhl 2009-04-23T03:47:53Z MetaCyc:RXN3O-4157|EC:2.6.1.58 molecular_function owl:Class
GO:1990080 biolink:NamedThing 2-phenylethylamine receptor activity Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity. got7fsn_ti beta-phenylethylamine receptor activity sp 2013-04-30T10:53:19Z molecular_function owl:Class
GO:0039652 biolink:NamedThing activation by virus of host NF-kappaB transcription factor activity Any process in which a virus starts, promotes, or enhances the activity of the host transcription factor NF-kappaB. got7fsn_ti activation of host NF-kappa-B by virus bf 2012-10-11T16:04:31Z VZ:841 biological_process owl:Class
GO:0018387 biolink:NamedThing N-terminal peptidyl-amino acid deamination to pyruvic acid The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. got7fsn_ti RESID:AA0127 biological_process owl:Class
GO:0048768 biolink:NamedThing root hair cell tip growth Localized growth of a plant root hair tip by extension of the cell wall. got7fsn_ti root hair tip growth biological_process owl:Class
GO:0016170 biolink:NamedThing interleukin-15 receptor binding Binding to an interleukin-15 receptor. got7fsn_ti IL-15|interleukin-15 receptor ligand molecular_function owl:Class
GO:0004739 biolink:NamedThing pyruvate dehydrogenase (acetyl-transferring) activity Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. got7fsn_ti pyruvate dehydrogenase complex activity|pyruvate dehydrogenase (lipoamide) activity|PDH|pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)|MtPDC (mitochondrial pyruvate dehydogenase complex) activity|pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity EC:1.2.4.1|RHEA:19189 molecular_function owl:Class
GO:0008856 biolink:NamedThing exodeoxyribonuclease X activity Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes. got7fsn_ti Escherichia coli endodeoxyribonuclease activity|deoxyribonuclease X activity|Escherichia coli endodeoxyribonuclease X activity EC:3.1.11.-|MetaCyc:3.1.22.5-RXN molecular_function owl:Class
GO:0044075 biolink:NamedThing modulation by symbiont of host vacuole organization Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism. got7fsn_ti modulation by symbiont of host vacuole biogenesis|modulation of host vacuole organization by symbiont|modulation by symbiont of host vacuole organisation|regulation by symbiont of host vacuole organization biological_process owl:Class
GO:2000994 biolink:NamedThing regulation of mannan catabolic process Any process that modulates the frequency, rate or extent of mannan catabolic process. got7fsn_ti regulation of mannan catabolism|regulation of mannan degradation|regulation of mannan breakdown tt 2011-08-08T03:19:03Z biological_process owl:Class
GO:2000924 biolink:NamedThing regulation of cellodextrin metabolic process Any process that modulates the frequency, rate or extent of cellodextrin metabolic process. got7fsn_ti regulation of cellodextrin metabolism tt 2011-08-01T12:39:52Z biological_process owl:Class
GO:0019564 biolink:NamedThing aerobic glycerol catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen. got7fsn_ti aerobic glycerol catabolism|aerobic glycerol breakdown|aerobic glycerol fermentation|aerobic glycerol degradation GO:0019565 MetaCyc:PWY0-381 biological_process owl:Class
GO:0019563 biolink:NamedThing glycerol catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. got7fsn_ti glycerol catabolism|glycerol breakdown|glycerol degradation MetaCyc:PWY-4261|MetaCyc:PWY0-381 biological_process owl:Class
GO:0032633 biolink:NamedThing interleukin-4 production The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-4 secretion|interleukin-4 biosynthetic process|IL-4 production GO:0042224|GO:0072602|GO:0042097 biological_process owl:Class
GO:0019033 biolink:NamedThing viral tegument A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically. got7fsn_ti Wikipedia:Viral_tegument cellular_component owl:Class
GO:0006446 biolink:NamedThing regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. got7fsn_ti biological_process owl:Class
GO:0004636 biolink:NamedThing phosphoribosyl-ATP diphosphatase activity Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+). got7fsn_ti 1-(5-phosphoribosyl)-ATP diphosphohydrolase activity|phosphoribosyladenosine triphosphate pyrophosphatase activity|phosphoribosyl-ATP pyrophosphatase activity MetaCyc:HISTPRATPHYD-RXN|EC:3.6.1.31|KEGG_REACTION:R04035|RHEA:22828 molecular_function owl:Class
GO:0080070 biolink:NamedThing 8-methylthiooctyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 8-methylthiooctyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 8-methylthiooctyl-glucosinolate + adenosine 3',5'-bisphosphate. got7fsn_ti dhl 2009-04-13T04:07:58Z MetaCyc:RXNQT-4333 molecular_function owl:Class
GO:0050245 biolink:NamedThing quercitrinase activity Catalysis of the reaction: H(2)O + quercitrin = L-rhamnose + quercetin. got7fsn_ti quercitrin 3-L-rhamnohydrolase activity MetaCyc:QUERCITRINASE-RXN|RHEA:17465|EC:3.2.1.66|KEGG_REACTION:R02436 molecular_function owl:Class
GO:0047142 biolink:NamedThing enzyme-thiol transhydrogenase (glutathione-disulfide) activity Catalysis of the reaction: oxidized glutathione + [xanthine dehydrogenase] = reduced glutathione + xanthine-oxidase. got7fsn_ti enzyme-thiol transhydrogenase (oxidized-glutathione) activity|glutathione-dependent thiol:disulfide oxidoreductase activity|thiol:disulphide oxidoreductase activity|xanthine-dehydrogenase:glutathione-disulfide S-oxidoreductase activity|xanthine-dehydrogenase:oxidized-glutathione S-oxidoreductase activity|thiol:disulfide oxidoreductase activity|[xanthine-dehydrogenase]:oxidized-glutathione S-oxidoreductase activity|enzyme-thiol transhydrogenase (glutathione-disulphide) activity MetaCyc:1.8.4.7-RXN|EC:1.8.4.7 molecular_function owl:Class
GO:0005513 biolink:NamedThing detection of calcium ion The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal. got7fsn_ti calcium ion detection|detection of Ca2+ ion|Ca2+ ion detection|calcium ion sensing biological_process owl:Class
GO:0051592 biolink:NamedThing response to calcium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. got7fsn_ti response to Ca2+ ion biological_process owl:Class
GO:0001517 biolink:NamedThing N-acetylglucosamine 6-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. got7fsn_ti N-acetylglucosamine 6-O-sulphotransferase activity Reactome:R-HSA-6786012|Reactome:R-HSA-2046222|Reactome:R-HSA-3656269 molecular_function owl:Class
GO:1990829 biolink:NamedThing C-rich single-stranded DNA binding Binding to C-rich, single-stranded DNA. got7fsn_ti C-rich ssDNA binding sl 2015-08-20T16:05:12Z molecular_function owl:Class
GO:0055123 biolink:NamedThing digestive system development The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class
GO:0050836 biolink:NamedThing iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide. got7fsn_ti RESID:AA0357 biological_process owl:Class
GO:0004641 biolink:NamedThing phosphoribosylformylglycinamidine cyclo-ligase activity Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate. got7fsn_ti 5'-aminoimidazole ribonucleotide synthetase activity|AIR synthetase activity|phosphoribosyl-aminoimidazole synthetase activity|2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)|2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)|AIRS activity|AIR synthase activity|phosphoribosylaminoimidazole synthetase activity Reactome:R-HSA-73810|RHEA:23032|KEGG_REACTION:R04208|MetaCyc:AIRS-RXN|EC:6.3.3.1 molecular_function owl:Class
GO:0090323 biolink:NamedThing prostaglandin secretion involved in immune response The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. tb 2010-05-12T10:41:04Z biological_process owl:Class
GO:0004616 biolink:NamedThing phosphogluconate dehydrogenase (decarboxylating) activity Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. got7fsn_ti phosphogluconic acid dehydrogenase activity|6-phospho-D-gluconate dehydrogenase activity|6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)|6-phosphogluconate dehydrogenase (decarboxylating)|6-phosphogluconic carboxylase activity|6PGD activity|6-phosphogluconic dehydrogenase activity RHEA:10116|MetaCyc:6PGLUCONDEHYDROG-RXN|Reactome:R-HSA-71299|EC:1.1.1.44 molecular_function owl:Class
GO:0007138 biolink:NamedThing meiotic anaphase II The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0006039 biolink:NamedThing cell wall chitin catabolic process The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells. got7fsn_ti cell wall chitin breakdown|cell wall chitin degradation|cell wall chitin catabolism biological_process owl:Class
GO:0018523 biolink:NamedThing quinoline 2-oxidoreductase activity Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor. got7fsn_ti quinoline:acceptor 2-oxidoreductase (hydroxylating) RHEA:17749|EC:1.3.99.17|UM-BBD_reactionID:r0045|MetaCyc:1.3.99.17-RXN molecular_function owl:Class
GO:0103014 biolink:NamedThing beta-keto ester reductase activity Catalysis of the reaction: ethyl-(2R)-methyl-(3S)-hydroxybutanoate + NADP = ethyl-2-methylacetoacetate + NADPH + H+. got7fsn_ti MetaCyc:RXN0-1941 molecular_function owl:Class
GO:0050570 biolink:NamedThing 4-hydroxythreonine-4-phosphate dehydrogenase activity Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+. got7fsn_ti NAD+-dependent threonine 4-phosphate dehydrogenase activity|PdxA|L-threonine 4-phosphate dehydrogenase activity|4-(phosphohydroxy)-L-threonine dehydrogenase activity|NAD(+)-dependent threonine 4-phosphate dehydrogenase activity|4-(phosphonooxy)-L-threonine:NAD+ oxidoreductase activity MetaCyc:1.1.1.262-RXN|EC:1.1.1.262|RHEA:32275 molecular_function owl:Class
GO:0110057 biolink:NamedThing regulation of blood vessel endothelial cell differentiation Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation. got7fsn_ti kmv 2017-10-23T14:32:09Z biological_process owl:Class
GO:0045601 biolink:NamedThing regulation of endothelial cell differentiation Any process that modulates the frequency, rate or extent of endothelial cell differentiation. got7fsn_ti biological_process owl:Class
GO:0070483 biolink:NamedThing detection of hypoxia The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. got7fsn_ti detection of reduced oxygen levels biological_process owl:Class
GO:0003032 biolink:NamedThing detection of oxygen The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0033196 biolink:NamedThing tryparedoxin peroxidase activity Catalysis of the reaction: tryparedoxin + hydrogen peroxide = tryparedoxin disulfide + H2O. got7fsn_ti TXNPx activity MetaCyc:1.11.1.15-RXN molecular_function owl:Class
GO:0005522 biolink:NamedThing profilin binding Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. got7fsn_ti molecular_function owl:Class
GO:0043837 biolink:NamedThing valine dehydrogenase (NAD) activity Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH. got7fsn_ti ValDH EC:1.4.1.23|RHEA:30763 molecular_function owl:Class
GO:0048248 biolink:NamedThing CXCR3 chemokine receptor binding Binding to a CXCR3 chemokine receptor. got7fsn_ti molecular_function owl:Class
GO:0015818 biolink:NamedThing isoleucine transport The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-isoleucine transport biological_process owl:Class
GO:0071619 biolink:NamedThing phosphorylation of RNA polymerase II C-terminal domain serine 2 residues The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans. got7fsn_ti mah 2010-02-09T02:37:02Z biological_process owl:Class
GO:0022856 biolink:NamedThing protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti sorbitol PTS transporter activity molecular_function owl:Class
GO:0043851 biolink:NamedThing methanol-specific methylcobalamin:coenzyme M methyltransferase activity Catalysis of the reaction: a methylated methanol corrinoid protein + coenzyme M = a methanol corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M. got7fsn_ti methyltransferase 2|methanol-specific methylcobalamin:CoM methyltransferase activity|MtaA|MT2|methanol-specific methylcobalamin: coenzyme M methyltransferase activity|MtaC protein: coenzyme M methyltransferase activity|MtaC protein:coenzyme M methyltransferase activity This function is the second step in the pathway of methanogenesis from methanol. MetaCyc:RXN-8096 molecular_function owl:Class
GO:0001867 biolink:NamedThing complement activation, lectin pathway Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes. got7fsn_ti complement cascade, lectin pathway Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway. biological_process owl:Class
GO:0032248 biolink:NamedThing positive regulation of purine nucleoside transport Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti up regulation of purine nucleoside transport|up-regulation of purine nucleoside transport|upregulation of purine nucleoside transport|stimulation of purine nucleoside transport|activation of purine nucleoside transport biological_process owl:Class
GO:0032244 biolink:NamedThing positive regulation of nucleoside transport Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti stimulation of nucleoside transport|activation of nucleoside transport|up regulation of nucleoside transport|upregulation of nucleoside transport|up-regulation of nucleoside transport biological_process owl:Class
GO:0140696 biolink:NamedThing (S)-2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol. got7fsn_ti L-2-hydroxyglutarate dehydrogenase activity https://github.com/geneontology/go-ontology/issues/21957 pg 2021-08-11T14:16:32Z RHEA:58664|EC:1.1.5.13 molecular_function owl:Class
GO:0106292 biolink:NamedThing superoxide-generating NADPH oxidase activity Catalysis of the reaction: NADPH + 2 O2 = H(+) + NADP(+) + 2 superoxide. got7fsn_ti hjd 2020-08-19T15:58:36Z RHEA:63180 molecular_function owl:Class
GO:0016175 biolink:NamedThing superoxide-generating NAD(P)H oxidase activity Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-. got7fsn_ti cytochrome B-245 Reactome:R-HSA-5668731|Reactome:R-HSA-5218841|Reactome:R-HSA-5668718|Reactome:R-HSA-6789092|Reactome:R-HSA-1236967|Reactome:R-HSA-1497810|EC:1.6.3.-|Reactome:R-HSA-1222376|Reactome:R-HSA-6807557|Reactome:R-HSA-9673797|Reactome:R-HSA-5668629 molecular_function owl:Class
GO:0050501 biolink:NamedThing hyaluronan synthase activity Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP. got7fsn_ti HAS activity|alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1,4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity|seHAS|spHAS|alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity RHEA:12528|EC:2.4.1.212|MetaCyc:2.4.1.212-RXN|Reactome:R-HSA-2160851 molecular_function owl:Class
GO:0090124 biolink:NamedThing N-4 methylation of cytosine The covalent transfer of a methyl group to N-4 of cytosine in a DNA molecule. got7fsn_ti tb 2009-12-07T02:40:38Z biological_process owl:Class
GO:0102769 biolink:NamedThing dihydroceramide glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + a dihydroceramide = UDP + H+ + a D-glucosyl-N-acylsphinganine. got7fsn_ti EC:2.4.1.80|MetaCyc:RXN-7793 molecular_function owl:Class
GO:0097662 biolink:NamedThing SCF-Das1 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Das1 in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:26:27Z cellular_component owl:Class
GO:0002124 biolink:NamedThing territorial aggressive behavior Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics. got7fsn_ti territorial aggression biological_process owl:Class
GO:0047574 biolink:NamedThing 4-acetamidobutyryl-CoA deacetylase activity Catalysis of the reaction: 4-acetamidobutanoyl-CoA + H(2)O = 4-aminobutanoyl-CoA + acetate. got7fsn_ti 4-acetamidobutanoyl-CoA amidohydrolase activity|deacetylase-thiolesterase activity|aminobutyryl-CoA thiolesterase activity EC:3.5.1.51|KEGG_REACTION:R04056|MetaCyc:4-ACETAMIDOBUTYRYL-COA-DEACETYLASE-RXN|RHEA:22928 molecular_function owl:Class
GO:0102585 biolink:NamedThing cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside malonyltransferase activity Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucoside + malonyl-CoA + H+ <=> cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + coenzyme A. got7fsn_ti MetaCyc:RXN-15331 molecular_function owl:Class
GO:0045244 biolink:NamedThing succinate-CoA ligase complex (GDP-forming) A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP. got7fsn_ti succinyl-CoA synthetase, GDP-forming GO:0008325|GO:0045245 cellular_component owl:Class
GO:0080066 biolink:NamedThing 3-methylthiopropyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 3-methylthiopropyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 3-methylthiopropyl-glucosinolate + adenosine 3',5'-bisphosphate. got7fsn_ti dhl 2009-04-13T04:04:08Z MetaCyc:RXN-2209 molecular_function owl:Class
GO:0021739 biolink:NamedThing mesencephalic trigeminal nucleus development The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0044606 biolink:NamedThing phosphocholine hydrolase activity Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate. got7fsn_ti jl 2012-05-24T04:46:44Z molecular_function owl:Class
GO:0050396 biolink:NamedThing vomifoliol 4'-dehydrogenase activity Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH. got7fsn_ti vomifoliol:NAD+ 4'-oxidoreductase activity RHEA:22804|EC:1.1.1.221|KEGG_REACTION:R04412|MetaCyc:VOMIFOLIOL-4-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0071029 biolink:NamedThing nuclear ncRNA surveillance The set of processes involved in identifying and degrading defective or aberrant ncRNAs within the nucleus. got7fsn_ti nuclear aberrant ncRNA catabolic process|nuclear ncRNA quality control krc 2009-07-28T04:22:31Z biological_process owl:Class
GO:0014856 biolink:NamedThing skeletal muscle cell proliferation The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class
GO:1990986 biolink:NamedThing DNA recombinase disassembly The disaggregation of a DNA recombinase complex into its constituent strand exchange proteins (recombinases). got7fsn_ti Rad51 nucleoprotein filament disassembly pg 2016-11-18T13:13:56Z biological_process owl:Class
GO:0060816 biolink:NamedThing random inactivation of X chromosome Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on either the paternal or maternal X-chromosome in the XX sex. got7fsn_ti dph 2009-08-11T10:47:30Z biological_process owl:Class
GO:0102754 biolink:NamedThing chlorophyllide-b:phytyl-diphosphate phytyltransferase activity Catalysis of the reaction: H+ + chlorophyllide b + (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate <=> chlorophyll b + diphosphoric acid. got7fsn_ti MetaCyc:RXN-7674 molecular_function owl:Class
GO:1900771 biolink:NamedThing fumitremorgin B catabolic process The chemical reactions and pathways resulting in the breakdown of fumitremorgin B. got7fsn_ti fumitremorgin B catabolism|Lanosulin catabolism|Lanosulin catabolic process|fumitremorgin B degradation|Lanosulin breakdown|Lanosulin degradation|fumitremorgin B breakdown di 2012-06-04T09:25:43Z biological_process owl:Class
GO:1900767 biolink:NamedThing fonsecin metabolic process The chemical reactions and pathways involving fonsecin. got7fsn_ti fonsecin metabolism di 2012-06-04T09:21:14Z biological_process owl:Class
GO:0002281 biolink:NamedThing macrophage activation involved in immune response A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. got7fsn_ti macrophage activation during immune response|macrophage polarization involved in immune response biological_process owl:Class
GO:0033787 biolink:NamedThing cyanocobalamin reductase (cyanide-eliminating) activity Catalysis of the reaction: cob(I)alamin + hydrogen cyanide + NADP(+) = cyanocob(III)alamin + H(+) + NADPH. got7fsn_ti NADPH2:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity|cyanocobalamin reductase activity|cyanocobalamin reductase (NADPH; CN-eliminating) activity|cyanocobalamin reductase (NADPH, cyanide-eliminating) activity|NADPH:cyanocob(III)alamin oxidoreductase (cyanide-eliminating) activity|cob(I)alamin, cyanide:NADP+ oxidoreductase activity Formerly EC:1.6.99.12. EC:1.16.1.6|KEGG_REACTION:R02999|RHEA:16113|Reactome:R-HSA-3149519|MetaCyc:1.6.99.12-RXN molecular_function owl:Class
GO:0047926 biolink:NamedThing geranyl-diphosphate cyclase activity Catalysis of the reaction: geranyl diphosphate = (2S)-bornyl diphosphate. got7fsn_ti bornyl pyrophosphate synthetase activity|(+)-bornylpyrophosphate cyclase activity|bornyl pyrophosphate synthase activity|(+)-bornyl-diphosphate lyase (decyclizing)|bornyl diphosphate synthase activity MetaCyc:GERANYL-DIPHOSPHATE-CYCLASE-RXN|RHEA:18209|EC:5.5.1.8|KEGG_REACTION:R02007 molecular_function owl:Class
GO:0050401 biolink:NamedThing xylonate dehydratase activity Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O. got7fsn_ti D-xylo-aldonate dehydratase activity|D-xylonate hydro-lyase activity|D-xylonate hydro-lyase (2-dehydro-3-deoxy-D-xylonate-forming)|D-xylonate dehydratase activity MetaCyc:XYLONATE-DEHYDRATASE-RXN|RHEA:19157|EC:4.2.1.82|KEGG_REACTION:R02429 molecular_function owl:Class
GO:0033800 biolink:NamedThing isoflavone 7-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a 7-hydroxyisoflavone = S-adenosyl-L-homocysteine + a 7-methoxyisoflavone. got7fsn_ti S-adenosyl-L-methionine:hydroxyisoflavone 7-O-methyltransferase activity MetaCyc:RXN-6241|EC:2.1.1.150|RHEA:17933 molecular_function owl:Class
GO:0010085 biolink:NamedThing polarity specification of proximal/distal axis Any process resulting in the establishment of polarity along the proximal/distal axis. got7fsn_ti biological_process owl:Class
GO:0008867 biolink:NamedThing galactarate dehydratase activity Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O. got7fsn_ti D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)|D-galactarate hydro-lyase activity RHEA:16005|MetaCyc:GALACTARDEHYDRA-RXN|EC:4.2.1.42|KEGG_REACTION:R05608 molecular_function owl:Class
GO:1990478 biolink:NamedThing response to ultrasound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus. got7fsn_ti sl 2014-09-09T22:11:32Z biological_process owl:Class
GO:0015048 biolink:NamedThing phthalate dioxygenase reductase activity Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems. got7fsn_ti molecular_function owl:Class
GO:0016278 biolink:NamedThing lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. got7fsn_ti Reactome:R-HSA-6805755|Reactome:R-HSA-6805740|Reactome:R-HSA-3222237|Reactome:R-HSA-6805730 molecular_function owl:Class
GO:0042006 biolink:NamedThing masculinization of hermaphroditic germ-line The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans. got7fsn_ti biological_process owl:Class
GO:0040021 biolink:NamedThing hermaphrodite germ-line sex determination The determination of sex and sexual phenotype in the germ line of a hermaphrodite. got7fsn_ti GO:0042005 biological_process owl:Class
GO:0102325 biolink:NamedThing 2,2',3-trihydroxybiphenyl monooxygenase activity Catalysis of the reaction: biphenyl-2,2',3-triol + O2 + NADH + H+ <=> 2,2',3,3'-tetrahydroxybiphenyl + NAD + H2O. got7fsn_ti MetaCyc:RXN-13169|RHEA:63516 molecular_function owl:Class
GO:0004820 biolink:NamedThing glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). got7fsn_ti glycyl-transfer ribonucleate synthetase activity|glycine:tRNAGly ligase (AMP-forming) activity|glycyl-transfer RNA synthetase activity|glycyl-tRNA synthetase activity|glycyl-transfer ribonucleic acid synthetase activity|glycyl translase activity MetaCyc:GLYCINE--TRNA-LIGASE-RXN|RHEA:16013|Reactome:R-HSA-380240|Reactome:R-HSA-380048|EC:6.1.1.14 molecular_function owl:Class
GO:0004595 biolink:NamedThing pantetheine-phosphate adenylyltransferase activity Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. got7fsn_ti phosphopantetheine adenylyltransferase activity|ATP:pantetheine-phosphate adenylyltransferase activity|3'-dephospho-CoA pyrophosphorylase activity|ATP:pantetheine-4'-phosphate adenylyltransferase activity|dephospho-coenzyme A pyrophosphorylase activity|pantetheine phosphate adenylyltransferase activity|dephospho-CoA pyrophosphorylase activity|dephospho-CoA diphosphorylase activity|PPAT activity MetaCyc:PANTEPADENYLYLTRAN-RXN|RHEA:19801|EC:2.7.7.3|KEGG_REACTION:R03035|Reactome:R-HSA-196754 molecular_function owl:Class
GO:0106327 biolink:NamedThing acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP. got7fsn_ti hjd 2020-09-30T13:44:42Z EC:2.4.1.147|RHEA:46880 molecular_function owl:Class
GO:0034170 biolink:NamedThing toll-like receptor 11 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 11. got7fsn_ti TLR11 signaling pathway|toll-like receptor 11 signalling pathway biological_process owl:Class
GO:0090328 biolink:NamedThing regulation of olfactory learning Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue. got7fsn_ti tb 2010-05-14T10:37:22Z biological_process owl:Class
GO:0061348 biolink:NamedThing planar cell polarity pathway involved in ventricular septum morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the ventricular septum. got7fsn_ti dph 2010-10-01T10:47:49Z biological_process owl:Class
GO:1990052 biolink:NamedThing ER to chloroplast lipid transport The directed movement of a lipid from the endoplasmic reticulum (ER) to the chloroplast. got7fsn_ti ER to chloroplast lipid trafficking|endoplasmic reticulum to chloroplast lipid transport tb 2013-02-22T00:05:23Z biological_process owl:Class
GO:0030776 biolink:NamedThing (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline. got7fsn_ti S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity|norreticuline N-methyltransferase activity|(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity EC:2.1.1.115|RHEA:13005|MetaCyc:2.1.1.115-RXN molecular_function owl:Class
GO:0050957 biolink:NamedThing equilibrioception The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion. got7fsn_ti sensory perception of orientation with respect to gravity Wikipedia:Equilibrioception biological_process owl:Class
GO:0098625 biolink:NamedThing methylselenol reductase activity Catalysis of the reaction: NADPH + H+ + CH3SeOH => NADP+ + CH3SeH + H2O. got7fsn_ti Reactome:R-HSA-5263614 molecular_function owl:Class
GO:0047164 biolink:NamedThing isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase activity Catalysis of the reaction: biochanin-A + malonyl-CoA = 6'-malonyl-biochanin A + CoA. got7fsn_ti malonyl-CoA:isoflavone-7-O-beta-D-glucoside 6''-O-malonyltransferase activity|malonyl-CoA:flavone/flavonol 7-O-glucoside malonyltransferase activity|malonyl-coenzyme A:isoflavone 7-O-glucoside-6''-malonyltransferase activity|flavone/flavonol 7-O-beta-D-glucoside malonyltransferase activity|flavone (flavonol) 7-O-glycoside malonyltransferase activity|malonyl-coenzyme A:flavone/flavonol-7-O-glycoside malonyltransferase activity|MAT-7 EC:2.3.1.115|RHEA:15581|MetaCyc:2.3.1.115-RXN molecular_function owl:Class
GO:0031271 biolink:NamedThing lateral pseudopodium assembly The extension of a pseudopodium from the lateral area of a cell. got7fsn_ti lateral pseudopodium formation biological_process owl:Class
GO:0051897 biolink:NamedThing positive regulation of protein kinase B signaling Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. got7fsn_ti positive regulation of protein kinase B signalling cascade|activation of protein kinase B signaling cascade|positive regulation of protein kinase B signaling cascade|up-regulation of protein kinase B signaling cascade|positive regulation of PKB signaling cascade|positive regulation of PKB signalling cascade|stimulation of protein kinase B signaling cascade|positive regulation of AKT signalling cascade|positive regulation of AKT signaling cascade|upregulation of protein kinase B signaling cascade|up regulation of protein kinase B signaling cascade biological_process owl:Class
GO:0033407 biolink:NamedThing UCA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCA codon. got7fsn_ti serine tRNA|TCA codon-amino acid adaptor activity Note that in the standard genetic code, TCA codes for serine. molecular_function owl:Class
GO:0033809 biolink:NamedThing anthocyanin 6''-O-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + an anthocyanidin 3-O-beta-D-glucoside = CoA + an anthocyanidin 3-O-(6-O-malonyl-beta-D-glucoside). got7fsn_ti Dv3MaT|3MaT|malonyl-coenzymeA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity|malonyl-CoA:anthocyanidin-3-O-beta-D-glucoside 6''-O-malonyltransferase activity RHEA:16025|MetaCyc:2.3.1.171-RXN|EC:2.3.1.171 molecular_function owl:Class
GO:0102814 biolink:NamedThing caffeoyl-CoA:delphinidin-3,5,3'-triglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity Catalysis of the reaction: delphinidin 3,3',5-tri-O-beta-D-glucoside betaine + caffeoyl-CoA <=> delphinidin 3-O-glucosyl-5-O-(caffeoylglucoside-3'-O-glucoside) + coenzyme A. got7fsn_ti MetaCyc:RXN-8232 molecular_function owl:Class
GO:0048460 biolink:NamedThing flower formation The process that gives rise to the flower. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti GO:0048410 biological_process owl:Class
GO:0051327 biolink:NamedThing meiotic M phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle. got7fsn_ti M phase of meiotic cell cycle Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0060416 biolink:NamedThing response to growth hormone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. got7fsn_ti response to growth hormone stimulus biological_process owl:Class
GO:0047989 biolink:NamedThing hydroxybutyrate-dimer hydrolase activity Catalysis of the reaction: (R)-3-[(R)-3-hydroxybutanoyloxy]butanoate + H(2)O = 2 (R)-3-hydroxybutanoate + H(+). got7fsn_ti (R)-3-((R)-3-hydroxybutanoyloxy)butanoate hydroxybutanoylhydrolase activity|D-(-)-3-hydroxybutyrate-dimer hydrolase activity EC:3.1.1.22|MetaCyc:HYDROXYBUTYRATE-DIMER-HYDROLASE-RXN|RHEA:10172|KEGG_REACTION:R00048 molecular_function owl:Class
GO:0106349 biolink:NamedThing snRNA methylation The posttranscriptional addition of methyl groups to specific residues in an snRNA molecule. got7fsn_ti hjd 2020-12-18T15:55:19Z biological_process owl:Class
GO:0018698 biolink:NamedThing vinyl chloride reductive dehalogenase activity Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene. got7fsn_ti UM-BBD_reactionID:r0352|EC:1.97.1.-|MetaCyc:VCREDCHLOR-RXN molecular_function owl:Class
GO:0018122 biolink:NamedThing peptidyl-asparagine ADP-ribosylation The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine. got7fsn_ti RESID:AA0231 biological_process owl:Class
GO:0050346 biolink:NamedThing trans-L-3-hydroxyproline dehydratase activity Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+). got7fsn_ti trans-L-3-hydroxyproline hydro-lyase activity|trans-L-3-hydroxyproline hydro-lyase (Delta1-pyrroline 2-carboxylate-forming) MetaCyc:TRANS-L-3-HYDROXYPROLINE-DEHYDRATASE-RXN|RHEA:10320|KEGG_REACTION:R04374|EC:4.2.1.77 molecular_function owl:Class
GO:0140090 biolink:NamedThing membrane curvature sensor activity Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins. got7fsn_ti pg 2017-08-19T20:37:54Z molecular_function owl:Class
GO:0008289 biolink:NamedThing lipid binding Binding to a lipid. got7fsn_ti molecular_function owl:Class
GO:0034907 biolink:NamedThing acetanilide 1,2-dioxygenase activity Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide. got7fsn_ti UM-BBD_reactionID:r0723|EC:1.14.12.- molecular_function owl:Class
GO:0032405 biolink:NamedThing MutLalpha complex binding Binding to a MutLalpha mismatch repair complex. got7fsn_ti molecular_function owl:Class
GO:0039672 biolink:NamedThing suppression by virus of host natural killer cell activation Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host. got7fsn_ti suppression by virus of host NK-cell activation bf 2013-09-25T11:08:19Z biological_process owl:Class
GO:0032815 biolink:NamedThing negative regulation of natural killer cell activation Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation. got7fsn_ti downregulation of natural killer cell activation|down regulation of natural killer cell activation|inhibition of natural killer cell activation|down-regulation of natural killer cell activation|negative regulation of NK cell activation biological_process owl:Class
GO:0006349 biolink:NamedThing regulation of gene expression by genetic imprinting Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself. got7fsn_ti regulation of gene expression by DNA imprinting Wikipedia:Genomic_imprinting biological_process owl:Class
GO:0046657 biolink:NamedThing folic acid catabolic process The chemical reactions and pathways resulting in the breakdown of folic acid, pteroylglutamic acid. got7fsn_ti vitamin B9 catabolism|folic acid breakdown|folate catabolism|folic acid catabolism|folic acid degradation|vitamin M catabolic process|vitamin B9 catabolic process|folate catabolic process|vitamin M catabolism biological_process owl:Class
GO:0031413 biolink:NamedThing regulation of buoyancy Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases. got7fsn_ti buoyancy regulation biological_process owl:Class
GO:0031043 biolink:NamedThing O-glycan processing, core 7 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc. got7fsn_ti biological_process owl:Class
GO:0098931 biolink:NamedThing virion attachment to host cell flagellum The process by which a virion attaches to a the host cell flagellum. Some DNA bacterial viruses use flagella to attach to the host cell. This contact with the flagellum facilitates concentration of phage particles around the entry receptor on the bacterial cell surface. got7fsn_ti VZ:3949 biological_process owl:Class
GO:0050933 biolink:NamedThing early stripe melanocyte differentiation The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development). got7fsn_ti early stripe melanocyte cell differentiation|early stripe melanophore differentiation biological_process owl:Class
GO:0061243 biolink:NamedThing mesonephric renal vesicle morphogenesis The process in which the anatomical structures of the mesonephric renal vesicle are generated and organized. The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells. got7fsn_ti dph 2010-08-19T03:20:21Z biological_process owl:Class
GO:0004373 biolink:NamedThing glycogen (starch) synthase activity Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1). got7fsn_ti UDP-glycogen synthase activity|UDP-glucose-glycogen glucosyltransferase activity|UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity|uridine diphosphoglucose-glycogen glucosyltransferase activity|UDPG-glycogen synthetase activity|glycogen (starch) synthetase activity|UDPG-glycogen transglucosylase activity|UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity EC:2.4.1.11|Reactome:R-HSA-3858506|RHEA:18549|MetaCyc:2.4.1.11-RXN|Reactome:R-HSA-3828061|Reactome:R-HSA-3322001|Reactome:R-HSA-3322041|Reactome:R-HSA-3322009 molecular_function owl:Class
GO:0090068 biolink:NamedThing positive regulation of cell cycle process Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. got7fsn_ti tb 2009-09-09T11:39:52Z biological_process owl:Class
GO:0047741 biolink:NamedThing cetraxate benzylesterase activity Catalysis of the reaction: benzyl cetraxate + H(2)O = benzyl alcohol + cetraxate + H(+). got7fsn_ti cetraxate-benzyl-ester benzylhydrolase activity MetaCyc:CETRAXATE-BENZYLESTERASE-RXN|RHEA:23460|KEGG_REACTION:R03612|EC:3.1.1.70 molecular_function owl:Class
GO:0018580 biolink:NamedThing nitronate monooxygenase activity Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite. got7fsn_ti 2-nitropropane dioxygenase activity|nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity Where non-covalently bound FMN is used as the cofactor, see instead 'nitronate monooxygenase (FMN-linked) activity ; GO:0036434'. MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN|RHEA:28767|EC:1.13.12.16 molecular_function owl:Class
GO:0047822 biolink:NamedThing hypotaurine dehydrogenase activity Catalysis of the reaction: H(2)O + hypotaurine + NAD(+) = H(+) + NADH + taurine. got7fsn_ti hypotaurine:NAD+ oxidoreductase activity MetaCyc:HYPOTAURINE-DEHYDROGENASE-RXN|KEGG_REACTION:R01681|RHEA:17385|Reactome:R-HSA-1655453|EC:1.8.1.3 molecular_function owl:Class
GO:0051889 biolink:NamedThing negative regulation of timing of exogen Any process that stops, prevents, or reduces the frequency, rate or extent of timing of exogen, the shedding phase of the hair cycle. got7fsn_ti downregulation of exogen|negative regulation of exogen|inhibition of exogen|down-regulation of exogen|down regulation of exogen biological_process owl:Class
GO:0035573 biolink:NamedThing N-terminal peptidyl-serine trimethylation The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine. got7fsn_ti bf 2010-08-06T02:00:42Z biological_process owl:Class
GO:0018672 biolink:NamedThing anthranilate 3-monooxygenase (deaminating) activity Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+). got7fsn_ti anthranilate hydroxylase activity|anthranilate hydroxylase (deaminating) activity|anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)|anthranilate 2,3-dioxygenase (deaminating)|anthranilate 2,3-hydroxylase (deaminating) activity EC:1.14.13.35|RHEA:21236|UM-BBD_reactionID:r0578|KEGG_REACTION:R00980|MetaCyc:1.14.13.35-RXN molecular_function owl:Class
GO:0048524 biolink:NamedThing positive regulation of viral process Any process that activates or increases the frequency, rate or extent of a multi-organism process in which a virus is a participant. got7fsn_ti positive regulation of viral reproduction|up-regulation of viral life cycle|activation of viral life cycle|up regulation of viral life cycle|positive regulation of viral life cycle|upregulation of viral life cycle|stimulation of viral life cycle biological_process owl:Class
GO:0031777 biolink:NamedThing type 1 melanin-concentrating hormone receptor binding Binding to a type 1 melanin-concentrating hormone receptor. got7fsn_ti type 1 melanin-concentrating hormone receptor ligand molecular_function owl:Class
GO:0045819 biolink:NamedThing positive regulation of glycogen catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. got7fsn_ti upregulation of glycogen catabolic process|stimulation of glycogen catabolic process|positive regulation of glycogen breakdown|positive regulation of glycogenolysis|up-regulation of glycogen catabolic process|positive regulation of glycogen degradation|up regulation of glycogen catabolic process|positive regulation of glycogen catabolism|activation of glycogen catabolic process biological_process owl:Class
GO:0030751 biolink:NamedThing licodione 2'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity RHEA:18521|KEGG_REACTION:R03623|EC:2.1.1.65|MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0035402 biolink:NamedThing histone kinase activity (H3-T11 specific) Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3. got7fsn_ti histone-threonine kinase activity (H3-T11 specific)|histone threonine kinase activity (H3-T11 specific) bf 2010-03-24T10:04:40Z molecular_function owl:Class
GO:0052765 biolink:NamedThing reduced coenzyme F420 oxidase activity Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O. got7fsn_ti F420H2:oxygen oxidoreductase activity|coenzyme F420H2 oxidase activity|F420H2 oxidase activity ai 2011-09-29T04:33:54Z molecular_function owl:Class
GO:0031141 biolink:NamedThing induction of conjugation upon carbon starvation The process in which a cell initiates conjugation with cellular fusion upon carbon starvation. got7fsn_ti biological_process owl:Class
GO:0033754 biolink:NamedThing indoleamine 2,3-dioxygenase activity Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine. got7fsn_ti IDO|D-tryptophan:oxygen 2,3-oxidoreductase (decyclizing) activity|tryptophan pyrrolase activity MetaCyc:RXN-8665|EC:1.13.11.52|RHEA:14189|MetaCyc:RXN-8664 molecular_function owl:Class
GO:0010043 biolink:NamedThing response to zinc ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. got7fsn_ti response to zinc biological_process owl:Class
GO:0097449 biolink:NamedThing astrocyte projection A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. got7fsn_ti astrocyte process|vellous process|peripheral astrocyte process pr 2012-12-17T13:29:55Z NIF_Subcellular:sao1630537580 cellular_component owl:Class
GO:0050623 biolink:NamedThing berberine reductase activity Catalysis of the reaction: (R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH. got7fsn_ti (R)-canadine synthase activity|(R)-tetrahydroberberine:NADP+ oxidoreductase activity KEGG_REACTION:R07169|MetaCyc:1.5.1.31-RXN|RHEA:21268|EC:1.5.1.31 molecular_function owl:Class
GO:0047670 biolink:NamedThing anhydrotetracycline monooxygenase activity Catalysis of the reaction: anhydrotetracycline + H(+) + NADPH + O(2) = 12-dehydrotetracycline + H(2)O + NADP(+). got7fsn_ti anhydrotetracycline,NADPH:oxygen oxidoreductase (6-hydroxylating)|anhydrotetracycline oxygenase activity|ATC oxygenase activity KEGG_REACTION:R04060|EC:1.14.13.38|RHEA:11976|MetaCyc:ANHYDROTETRACYCLINE-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0039644 biolink:NamedThing suppression by virus of host NF-kappaB transcription factor activity Any process in which a virus stops, prevents, or reduces the activity of host NF-kappaB activity. got7fsn_ti inhibition of host NF-kappa-B by virus bf 2012-10-09T15:04:27Z VZ:695 biological_process owl:Class
GO:0039653 biolink:NamedThing suppression by virus of host transcription Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors. got7fsn_ti host transcription shutoff by virus|suppression by virus of host DNA-dependent transcription bf 2012-10-11T16:11:17Z VZ:1577 biological_process owl:Class
GO:0050522 biolink:NamedThing oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP. got7fsn_ti EC:1.20.98.- molecular_function owl:Class
GO:0017192 biolink:NamedThing N-terminal peptidyl-glutamine acetylation The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable. got7fsn_ti RESID:AA0045 biological_process owl:Class
GO:0010894 biolink:NamedThing negative regulation of steroid biosynthetic process Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. got7fsn_ti biological_process owl:Class
GO:0042868 biolink:NamedThing antisense RNA metabolic process The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis. got7fsn_ti antisense RNA metabolism biological_process owl:Class
GO:1990206 biolink:NamedThing jasmonyl-Ile conjugate hydrolase activity Catalysis of the reaction: jasmonyl-Ile + H2O = jasmonic acid + L-isoleucine. got7fsn_ti JA-Ile hydrolase tb 2013-10-07T18:37:49Z molecular_function owl:Class
GO:0102641 biolink:NamedThing (R)-lactaldehyde dehydrogenase activity Catalysis of the reaction: (R)-propane-1,2-diol + NADP <=> (R)-lactaldehyde + NADPH + H+. got7fsn_ti MetaCyc:RXN-15743 molecular_function owl:Class
GO:0030517 biolink:NamedThing negative regulation of axon extension Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. got7fsn_ti downregulation of axon extension|down regulation of axon extension|down-regulation of axon extension|inhibition of axon extension biological_process owl:Class
GO:0000344 biolink:NamedThing plastid-encoded plastid RNA polymerase complex B A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation. got7fsn_ti PEP-B cellular_component owl:Class
GO:0120056 biolink:NamedThing large intestinal transit Migration of ingested material along the length of the large intestine. got7fsn_ti large intestine transit|colonic transit|large bowel transit|colon transit krc 2017-06-13T20:52:01Z biological_process owl:Class
GO:0047241 biolink:NamedThing lipopolysaccharide N-acetylmannosaminouronosyltransferase activity Catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP. got7fsn_ti UDP-N-acetyl-beta-D-mannosaminouronate:lipopolysaccharide N-acetyl-beta-D-mannosaminouronosyltransferase activity|LPS N-acetylmannosaminouronosyltransferase activity|ManNAcA transferase activity|uridine diphosphoacetylmannosaminuronate-acetylglucosaminylpyrophosphorylundecaprenol acetylmannosaminuronosyltransferase activity EC:2.4.1.180|RHEA:28366|MetaCyc:2.4.1.180-RXN molecular_function owl:Class
GO:0047474 biolink:NamedThing long-chain fatty acid luciferin component ligase activity Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. got7fsn_ti long-chain-fatty-acid luciferin component ligase activity|long-chain-fatty-acid-luciferin-component ligase activity|acyl-protein synthetase activity|long-chain-fatty-acid:protein ligase (AMP-forming) EC:6.2.1.19|MetaCyc:6.2.1.19-RXN|RHEA:20101 molecular_function owl:Class
GO:0006893 biolink:NamedThing Golgi to plasma membrane transport The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. got7fsn_ti Golgi to plasma membrane vesicle-mediated transport biological_process owl:Class
GO:0019380 biolink:NamedThing 3-phenylpropionate catabolic process The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid. got7fsn_ti 3-phenylpropionate breakdown|3-phenylpropionate degradation|3-phenylpropionate catabolism MetaCyc:HCAMHPDEG-PWY|MetaCyc:P281-PWY biological_process owl:Class
GO:0061667 biolink:NamedThing URM1 ligase activity Catalysis of the transfer of URM1 to a substrate protein via the reaction X-URM1 + S --> X + S-URM1, where X is either an E2 or E3 enzyme, the X-URM1 linkage is a thioester bond, and the S-URM1 linkage is an isopeptide bond between the C-terminal amino acid of URM1 and the epsilon-amino group of lysine residues in the substrate. got7fsn_ti E3 dph 2014-11-06T14:04:43Z molecular_function owl:Class
GO:0042294 biolink:NamedThing URM1 transferase activity Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y --> Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages. got7fsn_ti molecular_function owl:Class
GO:0080132 biolink:NamedThing fatty acid alpha-hydroxylase activity Catalysis of the conversion of a fatty acid to an alpha-hydroxylated fatty acid. A hydroxyl group is added to the second carbon, counted from the carboxyl end, of a fatty acid chain. got7fsn_ti fatty acid 2-hydroxylase dhl 2009-05-06T04:43:36Z Reactome:R-HSA-5693761 molecular_function owl:Class
GO:0110015 biolink:NamedThing positive regulation of elastin catabolic process Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin. got7fsn_ti kmv 2017-05-10T14:54:12Z biological_process owl:Class
GO:0060310 biolink:NamedThing regulation of elastin catabolic process Any process that modulates the rate, frequency or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin. got7fsn_ti regulation of elastin catabolism|regulation of elastin degradation|regulation of elastin breakdown biological_process owl:Class
GO:0045986 biolink:NamedThing negative regulation of smooth muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction. got7fsn_ti down-regulation of smooth muscle contraction|down regulation of smooth muscle contraction|inhibition of smooth muscle contraction|downregulation of smooth muscle contraction|smooth muscle relaxation biological_process owl:Class
GO:0102491 biolink:NamedThing dGTP phosphohydrolase activity Catalysis of the reaction: dGTP + 2 H2O = dGMP + 2 hydrogenphosphate + 2 H+. got7fsn_ti MetaCyc:RXN-14208|EC:3.6.1.5 molecular_function owl:Class
GO:0006382 biolink:NamedThing adenosine to inosine editing The conversion of an adenosine residue to inosine in an RNA molecule by deamination. got7fsn_ti biological_process owl:Class
GO:0002255 biolink:NamedThing tissue kallikrein-kinin cascade A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. got7fsn_ti glandular kallikrein-kinin cascade biological_process owl:Class
GO:0052912 biolink:NamedThing 23S rRNA (guanine(748)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine. got7fsn_ti 23S rRNA m(1)G(748) methyltransferase activity KEGG_REACTION:R07233|EC:2.1.1.188|MetaCyc:RXN-11599|RHEA:42904 molecular_function owl:Class
GO:0098760 biolink:NamedThing response to interleukin-7 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus. got7fsn_ti response to IL-7 biological_process owl:Class
GO:0106364 biolink:NamedThing 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]. got7fsn_ti hjd 2021-02-09T15:52:26Z RHEA:20361 molecular_function owl:Class
GO:0046224 biolink:NamedThing bacteriocin metabolic process The chemical reactions and pathways involving bacteriocins, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. got7fsn_ti bacteriocin metabolism biological_process owl:Class
GO:0051975 biolink:NamedThing lysine biosynthetic process via alpha-aminoadipate and saccharopine The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine. got7fsn_ti lysine biosynthesis via aminoadipic acid and saccharopine|lysine biosynthetic process via aminoadipic acid and saccharopine MetaCyc:LYSINE-AMINOAD-PWY biological_process owl:Class
GO:0097208 biolink:NamedThing alveolar lamellar body A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. got7fsn_ti pr 2012-01-04T02:33:04Z cellular_component owl:Class
GO:0005832 biolink:NamedThing chaperonin-containing T-complex A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor. got7fsn_ti CCT particle|TriC cellular_component owl:Class
GO:2000642 biolink:NamedThing negative regulation of early endosome to late endosome transport Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport. got7fsn_ti vk 2011-04-21T11:20:06Z biological_process owl:Class
GO:0047535 biolink:NamedThing 2-alkyn-1-ol dehydrogenase activity Catalysis of the reaction: 2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + H(+) + NADH. got7fsn_ti 2-butyne-1,4-diol:NAD+ 1-oxidoreductase activity KEGG_REACTION:R03963|EC:1.1.1.165|MetaCyc:2-ALKYN-1-OL-DEHYDROGENASE-RXN|RHEA:19101 molecular_function owl:Class
GO:0080012 biolink:NamedThing trihydroxyferuloyl spermidine O-methyltransferase activity Catalysis of the reaction: trihydroxyferuloyl spermidine + S-adenosyl-L-methionine = dihydroxyferuloyl-sinapoyl spermidine + S-adenosyl-L-homocysteine + H+. got7fsn_ti N1,N5,N10-tris-(5-hydroxyferuloyl)spermidine O-methyltransferase activity MetaCyc:RXN-11263 molecular_function owl:Class
GO:0098605 biolink:NamedThing selenocystathionine beta-synthase activity Catalysis of the reaction: L-Serine + Selenohomocysteine => L-Selenocystathionine + H2O. got7fsn_ti dos 2014-04-16T11:07:50Z Reactome:R-HSA-2408559 molecular_function owl:Class
GO:0015690 biolink:NamedThing aluminum cation transport The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti aluminum transport|aluminium ion transport|aluminum ion transport|aluminium transport biological_process owl:Class
GO:0006812 biolink:NamedThing cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti di-, tri-valent inorganic cation transport|trivalent inorganic cation transport GO:0006819|GO:0015674|GO:0072512 biological_process owl:Class
GO:0018803 biolink:NamedThing 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate. got7fsn_ti 2'-carboxybenzalpyruvate aldolase activity|(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)|trans-2'-carboxybenzalpyruvate hydratase-aldolase activity|(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity|(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity MetaCyc:4.1.2.34-RXN|UM-BBD_reactionID:r0487|RHEA:16453|EC:4.1.2.34 molecular_function owl:Class
GO:0061689 biolink:NamedThing tricellular tight junction An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet. got7fsn_ti dph 2015-04-12T10:34:19Z cellular_component owl:Class
GO:0047354 biolink:NamedThing sphingosine cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + sphingosine = CMP + H(+) + sphingosyl-phosphocholine. got7fsn_ti sphingosine choline phosphotransferase activity|CDP-choline-sphingosine cholinephosphotransferase activity|CDP-choline:sphingosine cholinephosphotransferase activity|cytidine diphosphocholine-sphingosine cholinephosphotransferase activity|phosphorylcholine-sphingosine transferase activity KEGG_REACTION:R01929|MetaCyc:2.7.8.10-RXN|EC:2.7.8.10|RHEA:21224 molecular_function owl:Class
GO:0051451 biolink:NamedThing myoblast migration The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0075222 biolink:NamedThing sporangium germination The physiological, developmental and morphological changes that occur in a symbiont sporangium following release from dormancy up to the earliest signs of growth. A sporangium is a structure producing and containing spores. got7fsn_ti sporangium germination on or near host|symbiont sporangium germination on or near host|direct germination on or near host|germination of symbiont sporangium on or near host biological_process owl:Class
GO:0005114 biolink:NamedThing type II transforming growth factor beta receptor binding Binding to a type II transforming growth factor beta receptor. got7fsn_ti punt ligand|type II TGF-beta binding|transforming growth factor beta ligand binding to type II receptor|transforming growth factor beta receptor type II binding|TGF-beta type II binding|punt binding molecular_function owl:Class
GO:0035028 biolink:NamedThing leading edge cell fate determination The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:1990577 biolink:NamedThing C-terminal protein demethylation The removal of a methyl group from the C-terminal amino acid of a protein. got7fsn_ti mcc 2014-12-08T20:55:17Z biological_process owl:Class
GO:0000177 biolink:NamedThing cytoplasmic exosome (RNase complex) A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. got7fsn_ti prokaryotic exosome multienzyme ribonuclease complex|cytoplasmic exosome (ribonuclease complex)|cytoplasmic exosome multienzyme ribonuclease complex cellular_component owl:Class
GO:0044653 biolink:NamedThing dextrin alpha-glucosidase activity Catalysis of the reaction: dextrin + H2O = alpha-D-glucose. got7fsn_ti jl 2012-07-23T02:01:12Z EC:3.2.1.- molecular_function owl:Class
GO:0034784 biolink:NamedThing pivalyl-CoA mutase activity Catalysis of the reaction: pivalyl-CoA = 3-methylbutyryl-CoA. got7fsn_ti EC:5.4.99.-|UM-BBD_reactionID:r1033 molecular_function owl:Class
GO:0060409 biolink:NamedThing positive regulation of acetylcholine metabolic process Any process that increases the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. got7fsn_ti biological_process owl:Class
GO:0018758 biolink:NamedThing 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid. got7fsn_ti UM-BBD_reactionID:r0122 molecular_function owl:Class
GO:0050242 biolink:NamedThing pyruvate, phosphate dikinase activity Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate. got7fsn_ti pyruvic-phosphate dikinase activity|orthophosphate dikinase pyruvate|pyruvate,phosphate dikinase activity|pyruvate, Pi dikinase activity|pyruvate-inorganic phosphate dikinase activity|pyruvate-phosphate ligase activity|ATP:pyruvate, phosphate phosphotransferase activity|pyruvic-phosphate ligase activity|pyruvate-phosphate dikinase activity|pyruvate,orthophosphate dikinase activity|pyruvate-phosphate dikinase (phosphorylating)|PPDK EC:2.7.9.1|MetaCyc:PYRUVATEORTHOPHOSPHATE-DIKINASE-RXN|RHEA:10756|KEGG_REACTION:R00206 molecular_function owl:Class
GO:0030688 biolink:NamedThing preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. got7fsn_ti 43S preribosome Note that this complex is 43S in Saccharomyces. cellular_component owl:Class
GO:0043320 biolink:NamedThing natural killer cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell. got7fsn_ti NK cell degranulation|natural killer cell granule exocytosis|NK cell granule exocytosis biological_process owl:Class
GO:0010761 biolink:NamedThing fibroblast migration Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti fibroblast cell migration biological_process owl:Class
GO:0010294 biolink:NamedThing abscisic acid glucosyltransferase activity Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP. got7fsn_ti MetaCyc:RXN-8155|RHEA:31031 molecular_function owl:Class
GO:0071452 biolink:NamedThing cellular response to singlet oxygen Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. got7fsn_ti mah 2009-12-16T04:39:46Z biological_process owl:Class
GO:0000304 biolink:NamedThing response to singlet oxygen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst. got7fsn_ti biological_process owl:Class
GO:0102042 biolink:NamedThing dehydroquinate synthase activity Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+. got7fsn_ti RHEA:25956|MetaCyc:RXN-10032|EC:1.4.1.24 molecular_function owl:Class
GO:0043992 biolink:NamedThing histone acetyltransferase activity (H3-K9 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K9 specific) molecular_function owl:Class
GO:0051753 biolink:NamedThing mannan synthase activity Catalysis of the reaction: mannan(n) + GDP-mannose = mannan(n+1) + GDP. This reaction is the formation of the beta-(1->4)-linked mannan backbone in substrates such as galactomannan. got7fsn_ti galactomannan beta-1,4-mannosyltransferase activity|mannan beta-1,4-mannosyltransferase activity molecular_function owl:Class
GO:0010962 biolink:NamedThing regulation of glucan biosynthetic process Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. got7fsn_ti tb 2009-05-11T12:17:53Z biological_process owl:Class
GO:0072567 biolink:NamedThing chemokine (C-X-C motif) ligand 2 production The appearance of chemokine (C-X-C motif) ligand 2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti MIP2 production|SCYB2 production|CXCL2 production|MIP-2 production mah 2011-01-31T11:33:40Z biological_process owl:Class
GO:0002868 biolink:NamedThing negative regulation of B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion. got7fsn_ti downregulation of B cell deletion|negative regulation of B lymphocyte deletion|negative regulation of B-cell deletion|down-regulation of B cell deletion|down regulation of B cell deletion|inhibition of B cell deletion|negative regulation of B-lymphocyte deletion biological_process owl:Class
GO:1990753 biolink:NamedThing equatorial cell cortex The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression. got7fsn_ti kmv 2015-05-27T19:12:41Z cellular_component owl:Class
GO:0097510 biolink:NamedThing base-excision repair, AP site formation via deaminated base removal A base-excision repair, AP site formation process occurring via excision of a deaminated base. got7fsn_ti pr 2013-10-08T14:44:01Z biological_process owl:Class
GO:0050169 biolink:NamedThing peptide-tryptophan 2,3-dioxygenase activity Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine. got7fsn_ti tryptophan pyrrolooxygenase activity|peptide-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)|peptidyltryptophan 2,3-dioxygenase activity|pyrrolooxygenase activity MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN|EC:1.13.11.26 molecular_function owl:Class
GO:0007564 biolink:NamedThing regulation of chitin-based cuticle tanning Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning. got7fsn_ti regulation of cuticle tanning|regulation of cuticle hardening biological_process owl:Class
GO:0102162 biolink:NamedThing all-trans-8'-apo-beta-carotenal 15,15'-oxygenase Catalysis of the reaction: 8'-apo-beta,psi-caroten-8'-al + O2 <=> all-trans-retinal + 2,6-dimethylocta-2,4,6-trienedial. got7fsn_ti RHEA:26385|EC:1.13.11.75|MetaCyc:RXN-11783 molecular_function owl:Class
GO:0050956 biolink:NamedThing electroception The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location. got7fsn_ti electroception sense|electroceptive sense Wikipedia:Electroreception biological_process owl:Class
GO:0045772 biolink:NamedThing positive regulation of autophagosome size Any process that increases autophagosome size. got7fsn_ti activation of autophagic vacuole size|up-regulation of autophagic vacuole size|stimulation of autophagic vacuole size|upregulation of autophagic vacuole size|up regulation of autophagic vacuole size|positive regulation of autophagic vacuole size biological_process owl:Class
GO:0052768 biolink:NamedThing mannosyl-oligosaccharide 1,3-alpha-mannosidase activity Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide. got7fsn_ti alpha-1,3-mannosyl-oligosaccharide alpha-D-mannohydrolase activity|1,3-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity|1,3-alpha-mannosidase activity|alpha-1,3-mannosidase activity ai 2011-09-30T12:55:24Z EC:3.1.1.- molecular_function owl:Class
GO:0044876 biolink:NamedThing hercynylselenocysteine synthase Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 <=> 2 H2O + 2 hercynylselenocysteine. got7fsn_ti jl 2014-12-15T11:56:12Z MetaCyc:RXN-15803|RHEA:42680 molecular_function owl:Class
GO:0102184 biolink:NamedThing cycloartenol 4alpha-methyl oxidase activity Catalysis of the reaction: cycloartenol + NADH + O2 + H+ <=> 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD + H2O. got7fsn_ti MetaCyc:RXN-11946 molecular_function owl:Class
GO:0000760 biolink:NamedThing adaptation to pheromone regulating conjugation with mutual genetic exchange In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. got7fsn_ti adaptation to pheromone involved conjugation without cellular fusion|desensitization to pheromone during conjugation without cellular fusion biological_process owl:Class
GO:0032268 biolink:NamedThing regulation of cellular protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. got7fsn_ti regulation of cellular protein metabolism biological_process owl:Class
GO:0090171 biolink:NamedThing chondrocyte morphogenesis The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte. got7fsn_ti tb 2009-12-11T10:36:02Z biological_process owl:Class
GO:0047987 biolink:NamedThing hydroperoxide dehydratase activity Catalysis of the reaction: (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate = (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O. got7fsn_ti (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]|linoleic acid hydroperoxide isomerase|(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase activity|hydroperoxide isomerase activity|linoleate hydroperoxide isomerase|HPI MetaCyc:HYDROPEROXIDE-DEHYDRATASE-RXN|RHEA:25075|EC:4.2.1.92 molecular_function owl:Class
GO:0008124 biolink:NamedThing 4-alpha-hydroxytetrahydrobiopterin dehydratase activity Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O. got7fsn_ti 4a-hydroxytetrahydrobiopterin dehydratase activity|tetrahydrobiopterin dehydratase activity|pterin-4alpha-carbinolamine dehydratase activity|4a-hydroxytetrahydrobiopterin hydro-lyase activity|pterin-4-alpha-carbinolamine dehydratase activity|(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]|4alpha-hydroxy-tetrahydropterin dehydratase activity|pterin-4a-carbinolamine dehydratase activity|4-alpha-hydroxy-tetrahydropterin dehydratase activity Reactome:R-HSA-71146|KEGG_REACTION:R04734|EC:4.2.1.96|RHEA:11920|MetaCyc:RXN-7908 molecular_function owl:Class
GO:0030701 biolink:NamedThing NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]. got7fsn_ti NAD--azoferredoxin (ADP-ribose)transferase activity|NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity|NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity|ADP-ribosyltransferase activity|NAD-azoferredoxin (ADPribose)transferase activity EC:2.4.2.37|MetaCyc:2.4.2.37-RXN|RHEA:18077 molecular_function owl:Class
GO:0008292 biolink:NamedThing acetylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. got7fsn_ti acetylcholine formation|acetylcholine anabolism|acetylcholine synthesis|acetylcholine biosynthesis biological_process owl:Class
GO:0047531 biolink:NamedThing 2,5-diaminovalerate transaminase activity Catalysis of the reaction: 2-oxoglutarate + ornithine = 5-amino-2-oxopentanoate + L-glutamate. got7fsn_ti diamino-acid aminotransferase activity|diamino acid aminotransferase activity|diamino-acid transaminase activity|2,5-diaminopentanoate:2-oxoglutarate aminotransferase activity|2,5-diaminovalerate aminotransferase activity RHEA:16017|EC:2.6.1.8|MetaCyc:25-DIAMINOVALERATE-AMINOTRANSFERASE-RXN|KEGG_REACTION:R03248 molecular_function owl:Class
GO:0009045 biolink:NamedThing xylose isomerase activity Catalysis of the reaction: D-xylose = D-xylulose. got7fsn_ti D-xylose ketol-isomerase activity|D-xylose isomerase activity|D-xylose aldose-ketose-isomerase activity|D-xylose ketoisomerase activity EC:5.3.1.5|RHEA:22816|MetaCyc:XYLISOM-RXN molecular_function owl:Class
GO:0031835 biolink:NamedThing substance P receptor binding Binding to a substance P receptor. got7fsn_ti neurokinin-1 receptor binding|substance P receptor ligand molecular_function owl:Class
GO:0072653 biolink:NamedThing interferon-omega production The appearance of interferon-omega due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IFNW production|IFN-omega production|interferon-omega secretion Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072654 biological_process owl:Class
GO:0047368 biolink:NamedThing UDP-N-acetylgalactosamine-4-sulfate sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + UDP-N-acetyl-D-galactosamine 4-sulfate = adenosine 3',5'-diphosphate + H(+) + UDP-N-acetyl-D-galactosamine 4,6-disulfate. got7fsn_ti uridine diphospho-N-acetylgalactosamine 4-sulfate sulfotransferase activity|3'-phosphoadenylyl-sulfate:UDP-N-acetyl-D-galactosamine-4-sulfate 6-sulfotransferase activity|UDP-N-acetylgalactosamine-4-sulphate sulphotransferase activity|uridine diphosphoacetylgalactosamine 4-sulfate sulfotransferase activity KEGG_REACTION:R04476|EC:2.8.2.7|RHEA:14337|MetaCyc:2.8.2.7-RXN molecular_function owl:Class
GO:0043918 biolink:NamedThing cadaverine aminopropyltransferase activity Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine. got7fsn_ti cadaverine aminopropyl transferase activity EC:2.5.1.104 molecular_function owl:Class
GO:0050183 biolink:NamedThing phosphatidylcholine 12-monooxygenase activity Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O(2) = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H(2)O + NAD(+). got7fsn_ti oleate Delta(12)-hydroxylase activity|oleate delta12-monooxygenase activity|oleate D12-hydroxylase activity|ricinoleic acid synthase activity|oleate delta12-hydroxylase activity|1-acyl-2-oleoyl-sn-glycero-3-phosphocholine,NADH:oxygen oxidoreductase (12-hydroxylating) EC:1.14.18.4|MetaCyc:PHOSPHATIDYLCHOLINE-12-MONOOXYGENASE-RXN|RHEA:46360|KEGG_REACTION:R03476 molecular_function owl:Class
GO:0043286 biolink:NamedThing regulation of poly(3-hydroxyalkanoate) biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. got7fsn_ti regulation of poly(3-hydroxyalkanoate) synthesis|regulation of poly(3-hydroxyalkanoate) anabolism|regulation of PHA|regulation of poly(3-hydroxyalkanoate) formation|regulation of poly(3-hydroxyalkanoate) biosynthesis biological_process owl:Class
GO:0005452 biolink:NamedThing inorganic anion exchanger activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out). got7fsn_ti Reactome:R-HSA-427666|Reactome:R-HSA-5656248|Reactome:R-HSA-425577|Reactome:R-HSA-1237038|Reactome:R-HSA-1247665|Reactome:R-HSA-5627737|Reactome:R-HSA-425482 molecular_function owl:Class
GO:0035810 biolink:NamedThing positive regulation of urine volume Any process that increases the amount of urine excreted from the body over a unit of time. got7fsn_ti diuresis|elevation of urinary volume|increase in urine flow bf 2011-04-20T01:19:38Z biological_process owl:Class
GO:0008808 biolink:NamedThing cardiolipin synthase activity Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. got7fsn_ti cardiolipin synthetase activity|diphosphatidylglycerol synthase activity|cardiolipin synthetase 2 activity|cardiolipin synthase 2 activity GO:0043788 RHEA:31451|MetaCyc:CARDIOLIPSYN-RXN molecular_function owl:Class
GO:0033406 biolink:NamedThing UCC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UCC codon. got7fsn_ti TCC codon-amino acid adaptor activity|serine tRNA Note that in the standard genetic code, TCC codes for serine. molecular_function owl:Class
GO:0050860 biolink:NamedThing negative regulation of T cell receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell. got7fsn_ti down regulation of T cell receptor signaling pathway|negative regulation of T lymphocyte receptor signalling pathway|inhibition of T cell receptor signaling pathway|negative regulation of T-cell receptor signaling pathway|negative regulation of T-lymphocyte receptor signaling pathway|negative regulation of T-lymphocyte receptor signalling pathway|down-regulation of T cell receptor signaling pathway|negative regulation of TCR signaling pathway|negative regulation of T lymphocyte receptor signaling pathway|downregulation of T cell receptor signaling pathway|negative regulation of T cell receptor signalling pathway biological_process owl:Class
GO:1900247 biolink:NamedThing regulation of cytoplasmic translational elongation Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation. got7fsn_ti vw 2012-04-03T05:07:02Z biological_process owl:Class
GO:0039547 biolink:NamedThing suppression by virus of host TRAF activity Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components. got7fsn_ti inhibition of host TRAFs by virus This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. bf 2012-01-19T03:12:15Z biological_process owl:Class
GO:0052886 biolink:NamedThing 9,9'-dicis-carotene:quinone oxidoreductase activity Catalysis of the reaction: 9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol. got7fsn_ti ZDS activity|zeta-carotene desaturase activity|9,9'-di-cis-zeta-carotene desaturase activity EC:1.3.5.6|RHEA:30959|MetaCyc:RXN-11356|KEGG_REACTION:R09656 molecular_function owl:Class
GO:0042735 biolink:NamedThing protein body A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins. got7fsn_ti cellular_component owl:Class
GO:0004366 biolink:NamedThing glycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. got7fsn_ti alpha-glycerophosphate acyltransferase activity|glycerol phosphate transacylase activity|sn-glycerol 3-phosphate acyltransferase activity|glycerophosphate transacylase activity|ACP:sn-glycerol-3-phosphate acyltransferase activity|glycerol phosphate acyltransferase activity|glycerol 3-phosphate acyltransferase activity|sn-glycerol-3-phosphate acyltransferase activity|glycerophosphate acyltransferase activity|acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity|3-glycerophosphate acyltransferase activity EC:2.3.1.15|Reactome:R-HSA-75886|Reactome:R-HSA-1482695|RHEA:15325|MetaCyc:RXN-1381|Reactome:R-HSA-549112 molecular_function owl:Class
GO:0090680 biolink:NamedThing disruption by virus of host outer membrane A process by which a virus has a negative effect on the functioning of a host outer membrane. got7fsn_ti tb 2016-05-04T15:52:02Z biological_process owl:Class
GO:0061824 biolink:NamedThing cytosolic ciliogenesis The process in which an axoneme is exposed entirely or partially to the cytoplasm or by which the cytoplasmic portion is assembled or extended. Cytosolic ciliogenesis can occur following compartmentalized ciliogenesis, in which the cilium is formed within a compartment separated from the cytoplasm. got7fsn_ti intracellular ciliogenesis dph 2017-01-14T14:24:17Z biological_process owl:Class
GO:0061609 biolink:NamedThing fructose-1-phosphate aldolase activity Catalysis of the reaction: D-fructose-1-phosphate = dihydroxyacetone phosphate + D-glyceraldehyde. got7fsn_ti dph 2014-03-28T08:54:24Z Reactome:R-HSA-5656438|RHEA:30851|Reactome:R-HSA-70342 molecular_function owl:Class
GO:0004139 biolink:NamedThing deoxyribose-phosphate aldolase activity Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. got7fsn_ti deoxyribose-5-phosphate aldolase activity|2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity|phosphodeoxyriboaldolase activity|2-deoxyribose-5-phosphate aldolase activity|deoxyriboaldolase activity|2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming) KEGG_REACTION:R01066|Reactome:R-HSA-6787321|MetaCyc:DEOXYRIBOSE-P-ALD-RXN|EC:4.1.2.4|RHEA:12821 molecular_function owl:Class
GO:0036121 biolink:NamedThing double-stranded DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix. got7fsn_ti double-stranded DNA-dependent ATPase activity|dsDNA-dependent ATP-dependent DNA helicase activity|dsDNA-dependent ATPase activity|double-stranded DNA-dependent ATP-dependent DNA helicase activity bf 2012-02-20T02:53:51Z GO:0033676 molecular_function owl:Class
GO:0051448 biolink:NamedThing gonadotropin-releasing hormone binding Binding to gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. got7fsn_ti GnRH binding|gonadotrophin releasing hormone binding molecular_function owl:Class
GO:0042807 biolink:NamedThing central vacuole A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination. got7fsn_ti cellular_component owl:Class
GO:0086030 biolink:NamedThing adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation. got7fsn_ti adrenergic receptor signaling pathway involved in cardiac muscle relaxation via activation of AC|Gs-coupled adrenergic receptor signaling pathway involved in cardiac muscle relaxation|adrenergic receptor signaling pathway involved in cardiac muscle relaxation|adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation|adrenergic receptor-induced cardiac relaxation tb 2011-11-11T02:53:24Z biological_process owl:Class
GO:0086023 biolink:NamedThing adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process A series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart. got7fsn_ti adrenergic receptor signalling pathway involved in heart process|adrenergic receptor signaling pathway involved in heart process|beta-adrenergic receptor signalling pathway involved in heart process tb 2011-11-11T02:51:03Z biological_process owl:Class
GO:0034452 biolink:NamedThing dynactin binding Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity. got7fsn_ti molecular_function owl:Class
GO:0031764 biolink:NamedThing type 1 galanin receptor binding Binding to a type 1 galanin receptor. got7fsn_ti type 1 galanin receptor ligand molecular_function owl:Class
GO:0043801 biolink:NamedThing hexulose-6-phosphate synthase activity Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate. got7fsn_ti EC:4.1.2.43|MetaCyc:R10-RXN|RHEA:25201 molecular_function owl:Class
GO:0002539 biolink:NamedThing prostaglandin production involved in inflammatory response The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti prostaglandin production involved in acute inflammatory response biological_process owl:Class
GO:0039548 biolink:NamedThing suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. got7fsn_ti inhibition of host IRF3 by virus|suppression by virus of host interferon regulatory factor 3|inhibition of IRF3-dependent antiviral response|suppression by virus of host IRF3 activity https://github.com/geneontology/go-ontology/issues/21985 This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. bf 2012-01-19T04:04:26Z biological_process owl:Class
GO:0008826 biolink:NamedThing cysteine sulfinate desulfinase activity Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite. got7fsn_ti cysteine sulphinate desulphinase activity RHEA:28278|MetaCyc:RXN0-279 molecular_function owl:Class
GO:0102390 biolink:NamedThing mycophenolic acid acyl-glucuronide esterase activity Catalysis of the reaction: mycophenolic acid O-acyl-glucuronide(1-) + H2O <=> mycophenolate + H+ + D-glucopyranuronate. got7fsn_ti MetaCyc:RXN-13605|RHEA:34179|EC:3.1.1.93 molecular_function owl:Class
GO:0048556 biolink:NamedThing microsporocyte nucleus The nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte. got7fsn_ti microspore mother cell nucleus|pollen mother cell nucleus GO:0043074 cellular_component owl:Class
GO:0007119 biolink:NamedThing budding cell isotropic bud growth Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding. got7fsn_ti isotropic bud growth biological_process owl:Class
GO:0047666 biolink:NamedThing ammonia kinase activity Catalysis of the reaction: ATP + NH(4)(+) = ADP + 3 H(+) + phosphoramidate. got7fsn_ti phosphoramidate-adenosine diphosphate phosphotransferase activity|ATP:ammonia phosphotransferase activity|phosphoramidate-ADP-phosphotransferase activity MetaCyc:AMMONIA-KINASE-RXN|RHEA:11024|EC:2.7.3.8|KEGG_REACTION:R00141 molecular_function owl:Class
GO:0019918 biolink:NamedThing peptidyl-arginine methylation, to symmetrical-dimethyl arginine The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine. got7fsn_ti RESID:AA0069|RESID:AA0067 biological_process owl:Class
GO:0048822 biolink:NamedThing enucleate erythrocyte development The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti enucleate red blood cell development|enucleate RBC development biological_process owl:Class
GO:0000149 biolink:NamedThing SNARE binding Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. got7fsn_ti SNAP receptor binding Reactome:R-HSA-888589|Reactome:R-HSA-210430|Reactome:R-HSA-9023173|Reactome:R-HSA-372529|Reactome:R-HSA-374899|Reactome:R-HSA-380901|Reactome:R-HSA-372505|Reactome:R-HSA-376369|Reactome:R-HSA-380905|Reactome:R-HSA-380869|Reactome:R-HSA-265166|Reactome:R-HSA-376364|Reactome:R-HSA-374922|Reactome:R-HSA-376357|Reactome:R-HSA-380574|Reactome:R-HSA-210426|Reactome:R-HSA-917744 molecular_function owl:Class
GO:0015514 biolink:NamedThing nitrite efflux transmembrane transporter activity Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti nitrite extrusion permease activity molecular_function owl:Class
GO:0071737 biolink:NamedThing IgG B cell receptor complex An IgG immunoglobulin complex that is present in the plasma membrane of B cells and is composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. got7fsn_ti surface IgG2|surface IgG4|membrane-bound IgG2c|surface IgG2c|membrane-bound IgG2b|membrane-bound IgG2a|membrane-bound IgG2|surface IgG1|membrane-bound IgG4|surface IgG|surface IgG2b|membrane-bound IgG3|membrane-bound IgG|surface IgG2a|membrane-bound IgG1|surface IgG3 Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0032046 biolink:NamedThing micropexophagy-specific membrane apparatus A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole. got7fsn_ti MIPA|micropexophagic apparatus cellular_component owl:Class
GO:0047421 biolink:NamedThing N-acyl-D-glutamate deacylase activity Catalysis of the reaction: N-acyl-D-glutamate + H(2)O = D-glutamate + a carboxylate. got7fsn_ti N-acyl-D-glutamate amidohydrolase activity KEGG_REACTION:R01581|RHEA:12833|EC:3.5.1.82|MetaCyc:3.5.1.82-RXN molecular_function owl:Class
GO:0106142 biolink:NamedThing rRNA (adenine-N1-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(645) in 25S rRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(645) in 25S rRNA. got7fsn_ti 25S rRNA (adenine(645)-N(1))-methyltransferase|25S rRNA m(1)A(645) methyltransferase The m(1)A modification at position 645 in the large rRNA is highly conserved in eukaryotes. hjd 2018-08-22T20:13:21Z EC:2.1.1.287|RHEA:43792 molecular_function owl:Class
GO:0031866 biolink:NamedThing EP3 subtype prostaglandin E2 receptor binding Binding to an EP3 subtype prostaglandin E2 receptor. got7fsn_ti prostanoid EP3 receptor binding|EP3 subtype prostaglandin E2 receptor ligand molecular_function owl:Class
GO:0060828 biolink:NamedThing regulation of canonical Wnt signaling pathway Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. got7fsn_ti catenin import into nucleus|regulation of catenin import into nucleus|regulation of catenin protein nuclear translocation|regulation of Wnt receptor signaling pathway through beta-catenin|regulation of canonical Wnt receptor signalling pathway|regulation of canonical Wnt-activated signaling pathway|regulation of canonical Wnt receptor signaling pathway https://github.com/geneontology/go-ontology/issues/15268|https://github.com/geneontology/go-ontology/issues/13686 dph 2009-08-11T01:54:47Z GO:0035412|GO:0035411 biological_process owl:Class
GO:0103066 biolink:NamedThing 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity Catalysis of the reaction: 4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 4alpha-methyl-5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H. got7fsn_ti EC:1.1.1.170|MetaCyc:RXN66-18 molecular_function owl:Class
GO:0038108 biolink:NamedThing negative regulation of appetite by leptin-mediated signaling pathway A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food. got7fsn_ti inhibition of appetite by leptin signaling|negative regulation of appetite by leptin-mediated signalling pathway|suppression of appetite by leptin-mediated signaling pathway|reduction of appetite by leptin-mediated signaling bf 2012-03-09T11:14:36Z biological_process owl:Class
GO:0032099 biolink:NamedThing negative regulation of appetite Any process that reduces appetite. got7fsn_ti negative regulation of hunger|down regulation of appetite|appetite suppression|downregulation of appetite|down-regulation of appetite|inhibition of appetite biological_process owl:Class
GO:0034420 biolink:NamedThing co-translational protein acetylation The addition of an acetyl group to one or more amino acids in a protein, occurring before the protein has been completely translated and released from the ribosome. got7fsn_ti co-translational protein amino acid acetylation|cotranslational protein amino acid acetylation biological_process owl:Class
GO:0034540 biolink:NamedThing 3-monobromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3-monobromobisphenol A + 2 H+ + 2 e- = bisphenol A + HBr. got7fsn_ti UM-BBD_reactionID:r0824|EC:1.97.1.- molecular_function owl:Class
GO:0021608 biolink:NamedThing accessory nerve formation The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve. got7fsn_ti CN XI biosynthesis|CN XI formation biological_process owl:Class
GO:0030103 biolink:NamedThing vasopressin secretion The regulated release of vasopressin from secretory granules into the blood. got7fsn_ti biological_process owl:Class
GO:0060396 biolink:NamedThing growth hormone receptor signaling pathway The series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand. got7fsn_ti GH receptor signaling pathway|cellular response to growth hormone|growth hormone receptor signalling pathway biological_process owl:Class
GO:0047464 biolink:NamedThing heparosan-N-sulfate-glucuronate 5-epimerase activity Catalysis of the reaction: heparosan-N-sulfate D-glucuronate = heparosan-N-sulfate L-iduronate. got7fsn_ti heparosan-N-sulfate-D-glucuronosyl 5-epimerase activity|D-glucuronyl C-5 epimerase activity|heparosan-N-sulphate-glucuronate 5-epimerase activity|polyglucuronate epimerase activity|heparosan epimerase activity|poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase activity|C-5 uronosyl epimerase activity EC:5.1.3.17|RHEA:20197|MetaCyc:5.1.3.17-RXN molecular_function owl:Class
GO:0001325 biolink:NamedThing formation of extrachromosomal circular DNA Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats. got7fsn_ti assembly of extrachromosomal circular DNA biological_process owl:Class
GO:0017124 biolink:NamedThing SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. got7fsn_ti molecular_function owl:Class
GO:0018689 biolink:NamedThing naphthalene disulfonate 1,2-dioxygenase activity Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene). got7fsn_ti naphthalene disulphonate 1,2-dioxygenase activity UM-BBD_enzymeID:e0249 molecular_function owl:Class
GO:0050540 biolink:NamedThing 2-aminomuconate deaminase activity Catalysis of the reaction: 2-aminomuconate + H(2)O + H(+) = (Z)-5-oxohex-2-enedioate + NH(4)(+). got7fsn_ti 2-aminomuconate aminohydrolase activity MetaCyc:3.5.99.5-RXN|RHEA:20996|KEGG_REACTION:R03887|EC:3.5.99.5 molecular_function owl:Class
GO:0102921 biolink:NamedThing mannosylglycerate synthase activity Catalysis of the reaction: GDP-alpha-D-mannose + D-glycerate <=> H+ + 2-(alpha-D-mannosyl)-D-glycerate + GDP. got7fsn_ti EC:2.4.1.269|MetaCyc:RXN-8849|RHEA:30639 molecular_function owl:Class
GO:0047755 biolink:NamedThing isocitrate epimerase activity Catalysis of the reaction: D-threo-isocitrate = D-erythro-isocitrate. got7fsn_ti (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate 1-epimerase activity EC:5.1.2.6|KEGG_REACTION:R02318|MetaCyc:ISOCITRATE-EPIMERASE-RXN|RHEA:10820 molecular_function owl:Class
GO:0070451 biolink:NamedThing cell hair A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located. got7fsn_ti imaginal disc-derived wing hair|non-sensory hair Wikipedia:Membrane_nanotube cellular_component owl:Class
GO:0080107 biolink:NamedThing 8-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 8-methylthiopropyl-glucosinolate = 8-methylsulfinylpropyl-glucosinolate. got7fsn_ti dhl 2009-04-23T04:30:08Z molecular_function owl:Class
GO:0033807 biolink:NamedThing icosanoyl-CoA synthase activity Catalysis of the reaction: stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ = icosanoyl-CoA + CO2 + 2 NAD(P)+. got7fsn_ti C18-CoA elongase activity|stearoyl-CoA elongase activity|acyl-CoA elongase activity|stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing) activity MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN|EC:2.3.1.119 molecular_function owl:Class
GO:1990021 biolink:NamedThing Schaffer axon collateral Part of axon of a CA3 pyramidal neuron that projects to hippocampal area CA1. got7fsn_ti Schaffer collateral pr 2013-01-10T16:06:17Z NIF_Subcellular:nlx_subcell_20090511 cellular_component owl:Class
GO:0035170 biolink:NamedThing lymph gland crystal cell differentiation The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph. got7fsn_ti biological_process owl:Class
GO:0031740 biolink:NamedThing type A cholecystokinin receptor binding Binding to a type A cholecystokinin receptor. got7fsn_ti type A cholecystokinin receptor ligand molecular_function owl:Class
GO:0031739 biolink:NamedThing cholecystokinin receptor binding Binding to a cholecystokinin receptor. got7fsn_ti cholecystokinin receptor ligand molecular_function owl:Class
GO:0030418 biolink:NamedThing nicotianamine biosynthetic process The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. got7fsn_ti nicotianamine formation|nicotianamine anabolism|nicotianamine synthesis|nicotianamine biosynthesis biological_process owl:Class
GO:0035297 biolink:NamedThing regulation of Malpighian tubule diameter Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells. got7fsn_ti biological_process owl:Class
GO:0051990 biolink:NamedThing (R)-2-hydroxyglutarate dehydrogenase activity Catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. got7fsn_ti D-2-hydroxyglutarate dehydrogenase activity EC:1.1.99.39|RHEA:38295|Reactome:R-HSA-880053|Reactome:R-HSA-880007 molecular_function owl:Class
GO:0000827 biolink:NamedThing inositol-1,3,4,5,6-pentakisphosphate kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. got7fsn_ti Reactome:R-HSA-1855223|EC:2.7.4.21|Reactome:R-HSA-1855181 molecular_function owl:Class
GO:0008204 biolink:NamedThing ergosterol metabolic process The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light. got7fsn_ti ergosterol metabolism biological_process owl:Class
GO:0047680 biolink:NamedThing aryl-acylamidase activity Catalysis of the reaction: anilide + H(2)O = a carboxylate + aniline + H(+). got7fsn_ti AAA-2|aryl-acylamide amidohydrolase activity|pseudocholinesterase (associated with arylacylamidase)|brain acetylcholinesterase (is associated with AAA-2)|AAA-1 KEGG_REACTION:R01862|RHEA:20297|EC:3.5.1.13|MetaCyc:ARYL-ACYLAMIDASE-RXN molecular_function owl:Class
GO:0042286 biolink:NamedThing glutamate-1-semialdehyde 2,1-aminomutase activity Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. got7fsn_ti glutamate-1-semialdehyde aminotransferase activity|(S)-4-amino-5-oxopentanoate 4,5-aminomutase activity KEGG_REACTION:R02272|RHEA:14265|EC:5.4.3.8|MetaCyc:GSAAMINOTRANS-RXN molecular_function owl:Class
GO:0035975 biolink:NamedThing carbamoyl phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. got7fsn_ti carbamoyl phosphate degradation|carbamoyl phosphate catabolism|carbamoyl phosphate breakdown bf 2011-08-16T11:41:13Z biological_process owl:Class
GO:0052786 biolink:NamedThing alpha-linked polysaccharide catabolism to maltotriose The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose. got7fsn_ti alpha-amylase-mediated polysaccharide catabolism, producing maltotriose|maltotriose-forming alpha-amylase activity ai 2011-10-04T09:59:59Z biological_process owl:Class
GO:0036148 biolink:NamedThing phosphatidylglycerol acyl-chain remodeling Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains. got7fsn_ti bf 2012-03-14T01:14:23Z biological_process owl:Class
GO:0046471 biolink:NamedThing phosphatidylglycerol metabolic process The chemical reactions and pathways involving phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol. They are important constituents of cell membranes. got7fsn_ti phosphatidylglycerol metabolism biological_process owl:Class
GO:0102748 biolink:NamedThing geranylgeranyl-chlorophyll a reductase activity Catalysis of the reaction: H+ + geranylgeranyl-chlorophyll a + NADPH = dihydrogeranylgeranyl-chlorophyll a + NADP. got7fsn_ti MetaCyc:RXN-7664 molecular_function owl:Class
GO:0060645 biolink:NamedThing peripheral mammary gland bud epithelial cell differentiation The process in which a relatively unspecialized epithelial cell of the mammary placode becomes an epithelial cell at the periphery of the mammary gland bud. Cells at the periphery of the bud are larger that those of the surrounding epithelium and are arranged concentrically. got7fsn_ti dph 2009-05-29T08:06:16Z biological_process owl:Class
GO:0034562 biolink:NamedThing 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity Catalysis of the reaction: 2,2-bis(4-hydroxyphenyl)-1-propanol + NADH + H+ + O2 = 2,3-bis(4-hydroxyphenyl)-1,2-propanediol + NAD+ + H2O. got7fsn_ti UM-BBD_reactionID:r0864 molecular_function owl:Class
GO:0031760 biolink:NamedThing Edg-7 lysophosphatidic acid receptor binding Binding to an Edg-7 lysophosphatidic acid receptor. got7fsn_ti Edg-7 lysophosphatidic acid receptor ligand|LPA3 receptor binding molecular_function owl:Class
GO:0009650 biolink:NamedThing UV protection Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV. got7fsn_ti ultraviolet protection|ultraviolet resistance|ultraviolet tolerance|UV resistance|UV tolerance biological_process owl:Class
GO:0102728 biolink:NamedThing campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity Catalysis of the reaction: (5alpha)-campestan-3-one + NADP = H+ + campest-4-en-3-one + NADPH. got7fsn_ti RHEA:54416|MetaCyc:RXN-711 molecular_function owl:Class
GO:0097573 biolink:NamedThing glutathione oxidoreductase activity Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione. got7fsn_ti Note that this activity is different from GO:0015038 'glutathione disulfide oxidoreductase activity'. See PMID:18992757: "Grxs [glutaredoxins] can also reduce mixed disulfides between proteins or low molecular weight thiols and GSH in reactions that require only their N-terminal active- site cysteine. It is important to note that the reduction of glutathionylated substrates through the monothiol mechanism seems to be the major activity of Grxs; all dithiol Grxs described so far catalyze these reactions, but not all dithiol Grxs catalyze the reduction of protein disulfides by the dithiol mechanism". pr 2014-02-19T13:41:38Z molecular_function owl:Class
GO:0043908 biolink:NamedThing Ser(Gly)-tRNA(Ala) hydrolase activity Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala). got7fsn_ti Ser(Gly)-tRNAAla hydrolase activity EC:3.1.1.- molecular_function owl:Class
GO:0009419 biolink:NamedThing pilus tip The pointed extremity furthest from the cell of a pilus. got7fsn_ti fimbrial tip cellular_component owl:Class
GO:0043785 biolink:NamedThing cinnamoyl-CoA:phenyllactate CoA-transferase activity Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate. got7fsn_ti (E)-cinnamoyl-CoA:(R)-phenyllactate CoA-transferase activity|FldA MetaCyc:2.8.3.17-RXN|KEGG_REACTION:R07796|EC:2.8.3.17|RHEA:15601 molecular_function owl:Class
GO:0071313 biolink:NamedThing cellular response to caffeine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them. got7fsn_ti mah 2009-12-10T04:52:51Z biological_process owl:Class
GO:0005415 biolink:NamedThing nucleoside:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). got7fsn_ti sodium-dependent nucleoside transporter activity|nucleoside-sodium cotransporter activity GO:0008522 Reactome:R-HSA-109538|Reactome:R-HSA-109530|Reactome:R-HSA-109539 molecular_function owl:Class
GO:0008196 biolink:NamedThing vitellogenin receptor activity Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis. got7fsn_ti molecular_function owl:Class
GO:0051120 biolink:NamedThing hepoxilin A3 synthase activity Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3. got7fsn_ti Reactome:R-HSA-8942208|Reactome:R-HSA-2161794 molecular_function owl:Class
GO:0043128 biolink:NamedThing positive regulation of 1-phosphatidylinositol 4-kinase activity Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase. got7fsn_ti activation of 1-phosphatidylinositol 4-kinase activity|positive regulation of PI4K activity|up regulation of 1-phosphatidylinositol 4-kinase activity|up-regulation of 1-phosphatidylinositol 4-kinase activity|stimulation of 1-phosphatidylinositol 4-kinase activity|upregulation of 1-phosphatidylinositol 4-kinase activity biological_process owl:Class
GO:0034898 biolink:NamedThing hexadecyltrimethylammonium chloride monooxygenase activity Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O. got7fsn_ti EC:1.13.12.-|UM-BBD_reactionID:r1373 molecular_function owl:Class
GO:0008755 biolink:NamedThing O antigen polymerase activity Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide. got7fsn_ti O-antigen polymerase activity molecular_function owl:Class
GO:0033513 biolink:NamedThing L-lysine catabolic process to acetyl-CoA via 5-aminopentanamide The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA, via the intermediate 5-aminopentanamide. got7fsn_ti L-lysine degradation to acetyl-CoA via 5-aminopentanamide|L-lysine breakdown to acetyl-CoA via 5-aminopentanamide MetaCyc:PWY-5280 biological_process owl:Class
GO:0042248 biolink:NamedThing maintenance of polarity of follicular epithelium The maintenance of an established polarized follicular epithelial sheet. got7fsn_ti biological_process owl:Class
GO:0030908 biolink:NamedThing protein splicing The post-translational removal of peptide sequences from within a protein sequence. got7fsn_ti Wikipedia:Protein_splicing biological_process owl:Class
GO:0022840 biolink:NamedThing leak channel activity Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. got7fsn_ti molecular_function owl:Class
GO:0102313 biolink:NamedThing 1,8-cineole synthase activity Catalysis of the reaction: geranyl diphosphate(3-) + H2O <=> 1,8-cineole + diphosphoric acid. got7fsn_ti RHEA:32543|EC:4.2.3.108|MetaCyc:RXN-12980 molecular_function owl:Class
GO:0018683 biolink:NamedThing camphor 5-monooxygenase activity Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O. got7fsn_ti methylene hydroxylase activity|D-camphor-exo-hydroxylase activity|camphor hydroxylase activity|methylene monooxygenase activity|d-camphor monooxygenase activity|camphor 5-exo-hydroxylase activity|bornanone 5-exo-hydroxylase activity|2-bornanone 5-exo-hydroxylase activity|camphor methylene hydroxylase activity|camphor 5-exohydroxylase activity|(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)|cytochrome p450-cam activity|camphor 5-exo-methylene hydroxylase activity MetaCyc:R541-RXN|UM-BBD_enzymeID:e0300|EC:1.14.15.1|RHEA:13525 molecular_function owl:Class
GO:0140498 biolink:NamedThing mannan polymerase I complex A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19817 pg 2020-07-22T14:34:23Z cellular_component owl:Class
GO:0050302 biolink:NamedThing indole-3-acetaldehyde oxidase activity Catalysis of the reaction: (indol-3-yl)acetaldehyde + H(2)O + O(2) = (indol-3-yl)acetate + H(2)O(2) + H(+). got7fsn_ti (indol-3-yl)acetaldehyde:oxygen oxidoreductase activity|IAAld oxidase activity|indoleacetaldehyde oxidase activity|indole-3-acetaldehyde:oxygen oxidoreductase activity|IAA oxidase activity|AO1 RHEA:16277|EC:1.2.3.7|MetaCyc:INDOLE-3-ACETALDEHYDE-OXIDASE-RXN|KEGG_REACTION:R02681 molecular_function owl:Class
GO:0018391 biolink:NamedThing C-terminal peptidyl-glutamic acid tyrosinylation The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein. got7fsn_ti biological_process owl:Class
GO:0047716 biolink:NamedThing imidazole N-acetyltransferase activity Catalysis of the reaction: 1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA. got7fsn_ti imidazole acetylase activity|imidazole acetyltransferase activity|acetyl-CoA:imidazole N-acetyltransferase activity KEGG_REACTION:R03621|MetaCyc:IMIDAZOLE-N-ACETYLTRANSFERASE-RXN|RHEA:15813|EC:2.3.1.2 molecular_function owl:Class
GO:1900582 biolink:NamedThing o-orsellinic acid metabolic process The chemical reactions and pathways involving o-orsellinic acid. got7fsn_ti o-orsellinic acid metabolism di 2012-05-15T06:47:42Z biological_process owl:Class
GO:0036432 biolink:NamedThing all-trans undecaprenol kinase activity Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+. got7fsn_ti bf 2013-09-16T14:21:04Z RHEA:23752 molecular_function owl:Class
GO:1900580 biolink:NamedThing (17Z)-protosta-17(20),24-dien-3beta-ol catabolic process The chemical reactions and pathways resulting in the breakdown of (17Z)-protosta-17(20),24-dien-3beta-ol. got7fsn_ti (17Z)-protosta-17(20),24-dien-3beta-ol catabolism|(17Z)-protosta-17(20),24-dien-3beta-ol degradation|(17Z)-protosta-17(20),24-dien-3beta-ol breakdown di 2012-05-15T06:47:30Z biological_process owl:Class
GO:0004321 biolink:NamedThing fatty-acyl-CoA synthase activity Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. got7fsn_ti yeast fatty acid synthase activity|acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)|fatty acyl CoA synthase activity EC:2.3.1.86|RHEA:22896|MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN molecular_function owl:Class
GO:0033435 biolink:NamedThing AUA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AUA codon. got7fsn_ti ATA codon-amino acid adaptor activity|isoleucine tRNA Note that in the standard genetic code, ATA codes for isoleucine. molecular_function owl:Class
GO:0009746 biolink:NamedThing response to hexose Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus. got7fsn_ti response to hexose stimulus biological_process owl:Class
GO:0006391 biolink:NamedThing transcription initiation from mitochondrial promoter A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase. got7fsn_ti biological_process owl:Class
GO:0007229 biolink:NamedThing integrin-mediated signaling pathway A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti integrin-mediated signalling pathway biological_process owl:Class
GO:0039617 biolink:NamedThing T=3 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres. got7fsn_ti bf 2012-07-18T02:07:40Z VZ:806 cellular_component owl:Class
GO:0010486 biolink:NamedThing manganese:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in). got7fsn_ti manganese:hydrogen antiporter activity molecular_function owl:Class
GO:0035530 biolink:NamedThing chemokine (C-C motif) ligand 6 production The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CCL6 production bf 2010-05-07T10:21:15Z biological_process owl:Class
GO:0071551 biolink:NamedThing RIP homotypic interaction motif binding Binding to a RIP homotypic interaction motif (RHIM) of a protein. The RHIM is a 16-amino-acid motif found in some members, including RIP3, of a family of related kinases. got7fsn_ti RHIM binding mah 2010-01-13T03:03:51Z molecular_function owl:Class
GO:1901654 biolink:NamedThing response to ketone A response that results in a state of tolerance to ketone. got7fsn_ti process resulting in tolerance to ketone pr 2012-11-20T10:55:47Z GO:1990369 biological_process owl:Class
GO:0102872 biolink:NamedThing 1-16:0-2-18:2-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8361|EC:1.14.19.25 molecular_function owl:Class
GO:0070032 biolink:NamedThing synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, and complexin I (or orthologs thereof). got7fsn_ti Vamp2-Snap25-Stx1a-Cplx1 complex|SNARE complex (Vamp2, Snap25, Stx1a, Cplx1) cellular_component owl:Class
GO:0016239 biolink:NamedThing positive regulation of macroautophagy Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation. got7fsn_ti up regulation of macroautophagy|up-regulation of macroautophagy|activation of macroautophagy|upregulation of macroautophagy|positive regulation of starvation-induced autophagy|stimulation of macroautophagy biological_process owl:Class
GO:0016165 biolink:NamedThing linoleate 13S-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. got7fsn_ti lipoxydase activity|lipoxygenase activity|lionoleate:O2 oxidoreductase activity|lipoperoxidase activity|fat oxidase activity|lipoxidase activity|linoleate:oxygen 13-oxidoreductase activity|carotene oxidase activity RHEA:22780|EC:1.13.11.12|MetaCyc:LIPOXYGENASE-RXN molecular_function owl:Class
GO:0051934 biolink:NamedThing catecholamine uptake involved in synaptic transmission The uptake of catecholamine neurotransmitters by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. got7fsn_ti catecholamine neurotransmitter recycling|catecholamine reuptake during transmission of nerve impulse|catecholamine uptake during transmission of nerve impulse|catecholamine neurotransmitter import into neuron|catecholamine neurotransmitter reuptake|catecholamine neurotransmitter import into glial cell biological_process owl:Class
GO:0010309 biolink:NamedThing acireductone dioxygenase [iron(II)-requiring] activity Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+). got7fsn_ti acireductone dioxygenase (Fe2+-requiring) activity|aci-reductone dioxygenase|2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase|1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)|ARD'|acireductone dioxygenase activity|E-2'|ARD1|1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity Reactome:R-HSA-1237119|MetaCyc:R147-RXN|EC:1.13.11.54|KEGG_REACTION:R07364|RHEA:24504 molecular_function owl:Class
GO:0045227 biolink:NamedThing capsule polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi. got7fsn_ti capsule polysaccharide anabolism|capsule polysaccharide formation|capsular polysaccharide biosynthetic process|capsule polysaccharide biosynthesis|capsule polysaccharide synthesis|capsular polysaccharide biosynthesis biological_process owl:Class
GO:0051653 biolink:NamedThing spindle localization Any process in which is the spindle is transported to, and/or maintained in, a specific location. got7fsn_ti establishment and maintenance of spindle localization|spindle localisation biological_process owl:Class
GO:0070582 biolink:NamedThing theta DNA replication A DNA-dependent DNA replication process in which a double-stranded DNA molecule is synthesized from a circular duplex template. got7fsn_ti theta replication mah 2009-04-22T02:54:50Z biological_process owl:Class
GO:0000468 biolink:NamedThing generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. got7fsn_ti processing at B2 biological_process owl:Class
GO:0071164 biolink:NamedThing RNA trimethylguanosine synthase activity Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine. got7fsn_ti snRNA methyltransferase activity|small nuclear RNA methyltransferase activity|cap hypermethylase activity mah 2009-11-19T03:23:20Z molecular_function owl:Class
GO:0052588 biolink:NamedThing diacetyl reductase ((S)-acetoin forming) activity Catalysis of the reaction: (S)-acetoin + NAD(+) = diacetyl + H(+) + NADH. got7fsn_ti (S)-acetoin dehydrogenase activity EC:1.1.1.304|RHEA:27286|KEGG_REACTION:R09078|MetaCyc:RXN-11032 molecular_function owl:Class
GO:0019152 biolink:NamedThing acetoin dehydrogenase activity Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. got7fsn_ti diacetyl reductase activity EC:1.1.1.304|EC:1.1.1.303|KEGG_REACTION:R02343|MetaCyc:ACETOINDEHYDROG-RXN molecular_function owl:Class
GO:0030784 biolink:NamedThing 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline. got7fsn_ti S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity MetaCyc:2.1.1.116-RXN|EC:2.1.1.116|RHEA:17789 molecular_function owl:Class
GO:0042387 biolink:NamedThing plasmatocyte differentiation The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response. got7fsn_ti biological_process owl:Class
GO:0018166 biolink:NamedThing C-terminal protein-tyrosinylation The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase. got7fsn_ti See also the molecular function term 'tubulin-tyrosine ligase activity ; GO:0004835'. RESID:AA0257 biological_process owl:Class
GO:0009010 biolink:NamedThing sorbitol-6-phosphate 2-dehydrogenase activity Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. got7fsn_ti ketosephosphate reductase activity|D-glucitol-6-phosphate dehydrogenase activity|sorbitol-6-P-dehydrogenase activity|D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity|D-sorbitol 6-phosphate dehydrogenase activity|D-sorbitol-6-phosphate dehydrogenase activity|glucitol-6-phosphate dehydrogenase activity MetaCyc:SORB6PDEHYDROG-RXN|RHEA:19837|EC:1.1.1.140 molecular_function owl:Class
GO:0034043 biolink:NamedThing 5-hydroxymethyluracil DNA N-glycosylase activity Catalysis of the removal of 5-hydroxymethyluracil bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. got7fsn_ti 5-hmU DNA N-glycosylase activity molecular_function owl:Class
GO:0042727 biolink:NamedThing flavin-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position. got7fsn_ti flavin-containing compound biosynthesis|vitamin B2 and derivative biosynthesis|flavin-containing compound synthesis|flavin-containing compound anabolism|riboflavin and derivative biosynthetic process|riboflavin and derivative biosynthesis|vitamin B2 and derivative biosynthetic process|flavin-containing compound formation biological_process owl:Class
GO:1990218 biolink:NamedThing positive regulation by symbiont of abscisic acid levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-10T15:54:10Z biological_process owl:Class
GO:0075343 biolink:NamedThing modulation by symbiont of abscisic acid levels in host The alteration by an organism of the levels of abscisic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti Note that this term is intended for use in annotation of symbiont gene products. For host gene products that regulate abscisic acid levels in the host, consider annotating to 'regulation of abscisic acid mediated signaling ; GO:0009787' or 'regulation of abscisic acid biosynthetic process ; GO:0010115'. biological_process owl:Class
GO:0102649 biolink:NamedThing acetoacetyl-ACP synthase activity Catalysis of the reaction: acetyl-CoA + malonyl-CoA + H+ + a holo-[acyl-carrier protein] <=> acetoacetyl-ACP + 2 coenzyme A + carbon dioxide. got7fsn_ti MetaCyc:RXN-15810 molecular_function owl:Class
GO:0034802 biolink:NamedThing branched-chain dodecylbenzene sulfonate monooxygenase activity Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite. got7fsn_ti EC:1.14.13.-|UM-BBD_reactionID:r1079 molecular_function owl:Class
GO:0050295 biolink:NamedThing steryl-beta-glucosidase activity Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol. got7fsn_ti steryl-b-glucosidase activity|cholesteryl-beta-D-glucoside glucohydrolase activity KEGG_REACTION:R01460|RHEA:11956|EC:3.2.1.104|MetaCyc:STERYL-BETA-GLUCOSIDASE-RXN molecular_function owl:Class
GO:0120278 biolink:NamedThing negative regulation of cerebral blood circulation Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation. got7fsn_ti down regulation of cerebral blood circulation|inhibition of cerebral blood circulation|downregulation of cerebral blood circulation|negative regulation of telencephalon blood circulation|negative regulation of cerebrum blood circulation|down-regulation of cerebral blood circulation https://github.com/geneontology/go-ontology/issues/20107 krc 2020-10-21T07:02:05Z biological_process owl:Class
GO:1990566 biolink:NamedThing I(KACh) inward rectifier potassium channel complex An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G protein-coupled receptor signalling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits. got7fsn_ti muscarinic potassium channel complex|GIRK1-GIRK4 G protein-coupled atrial inward rectifier potassium channel complex|Kir3.1-Kir3.4 G protein-coupled atrial inward rectifier potassium channel complex Examples of this are KCNJ3 and KCNJ5 in human (Uniprot symbols P48549 and P48544) in PMID:9765280 inferred from orthology sequence evidence. ame 2014-11-26T15:16:14Z cellular_component owl:Class
GO:0004395 biolink:NamedThing hexaprenyldihydroxybenzoate methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate. got7fsn_ti S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity|DHHB-Mt activity|DHHB methyltransferase activity|dihydroxyhexaprenylbenzoate methyltransferase activity|3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity EC:2.1.1.114|RHEA:14121|MetaCyc:2.1.1.114-RXN molecular_function owl:Class
GO:0008074 biolink:NamedThing guanylate cyclase complex, soluble Complex that possesses guanylate cyclase activity and is not bound to a membrane. got7fsn_ti See also the molecular function term 'guanylate cyclase activity ; GO:0004383'. cellular_component owl:Class
GO:0102164 biolink:NamedThing 2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity Catalysis of the reaction: 2-heptyl-4-quinolone + NADH + O2 + H+ <=> 2-heptyl-3-hydroxy-4-quinolone + NAD + H2O. got7fsn_ti MetaCyc:RXN-11849|RHEA:37871|EC:1.14.13.182 molecular_function owl:Class
GO:0047433 biolink:NamedThing branched-chain-2-oxoacid decarboxylase activity Catalysis of the reaction: (S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal + CO(2). got7fsn_ti (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)|branched-chain keto acid decarboxylase activity|branched-chain oxo acid decarboxylase activity|(3S)-3-methyl-2-oxopentanoate carboxy-lyase activity|BCKA|branched-chain alpha-keto acid decarboxylase activity EC:4.1.1.72|RHEA:21108|KEGG_REACTION:R03894|MetaCyc:4.1.1.72-RXN molecular_function owl:Class
GO:0015021 biolink:NamedThing heparin-sulfate lyase activity Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar. got7fsn_ti heparin-sulfate eliminase activity|heparitin-sulfate lyase activity|heparitinase I|heparin-sulphate lyase activity|heparitinase II|[heparan sulfate]-sulfate lyase activity EC:4.2.2.8|MetaCyc:4.2.2.8-RXN molecular_function owl:Class
GO:0035169 biolink:NamedThing lymph gland plasmatocyte differentiation The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte. got7fsn_ti lymph gland plasmatocyte cell differentiation biological_process owl:Class
GO:0022003 biolink:NamedThing negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands. got7fsn_ti fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate|fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate|fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate|fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate|fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate|fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate biological_process owl:Class
GO:0070122 biolink:NamedThing isopeptidase activity Catalysis of the hydrolysis of an isopeptide bond. An isopeptide bond is an amide linkage between a carboxyl group of one amino acid and an amino group of another amino acid in which at least one of these groups is not on the a-carbon of one of the amino acids (for example, the link between an epsilon-amino group of a lysine molecule to a carboxyl group on a second amino acid is an isopeptide bond). got7fsn_ti molecular_function owl:Class
GO:0102812 biolink:NamedThing 4-coumaroyl-CoA:cyanidin-3-O-beta-D-glucoside-6''-O-acyltransferase activity Catalysis of the reaction: 4-coumaryl-CoA + cyanidin 3-O-beta-D-glucoside betaine <=> cyanidin 3-(p-coumaroyl)-glucoside + coenzyme A. got7fsn_ti MetaCyc:RXN-8204 molecular_function owl:Class
GO:0000832 biolink:NamedThing inositol hexakisphosphate 5-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate. got7fsn_ti ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity EC:2.7.4.21|KEGG_REACTION:R09087|MetaCyc:2.7.1.152-RXN|RHEA:12793 molecular_function owl:Class
GO:0071348 biolink:NamedThing cellular response to interleukin-11 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-11 stimulus. got7fsn_ti cellular response to IL-11 mah 2009-12-11T02:49:29Z biological_process owl:Class
GO:0061970 biolink:NamedThing maintenance of right sidedness The organization process that preserves the right sidedness in an organism's body plan or part of an organism with respect to the left and right halves. got7fsn_ti dph 2018-02-12T16:45:33Z biological_process owl:Class
GO:1900597 biolink:NamedThing demethylkotanin metabolic process The chemical reactions and pathways involving demethylkotanin. got7fsn_ti demethylkotanin metabolism di 2012-05-15T06:54:52Z biological_process owl:Class
GO:0034865 biolink:NamedThing 2,4,4-trimethylpentanoate-CoA ligase activity Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-. got7fsn_ti UM-BBD_reactionID:r1271 molecular_function owl:Class
GO:0005848 biolink:NamedThing mRNA cleavage stimulating factor complex A protein complex required for mRNA cleavage but not for poly(A) addition. got7fsn_ti cleavage stimulation factor activity|CstF complex cellular_component owl:Class
GO:0061867 biolink:NamedThing establishment of mitotic spindle asymmetry The mitotic spindle organization process by which a mitotic spindle becomes asymmetric either in position or structure. got7fsn_ti dph 2017-04-28T12:39:13Z biological_process owl:Class
GO:0042661 biolink:NamedThing regulation of mesodermal cell fate specification Any process that modulates the frequency, rate or extent of mesoderm cell fate specification. got7fsn_ti biological_process owl:Class
GO:0015385 biolink:NamedThing sodium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). got7fsn_ti sodium:hydrogen antiporter activity|sodium/hydrogen antiporter activity|sodium:hydrogen exchange activity|pH-dependent sodium:hydrogen antiporter activity|sodium:hydrogen exchanger|pH-dependent sodium:proton antiporter activity GO:0015502 Reactome:R-HSA-425983|Reactome:R-HSA-2872444|Reactome:R-HSA-425994|RHEA:29251|Reactome:R-HSA-426015|Reactome:R-HSA-425965|Reactome:R-HSA-2872463|Reactome:R-HSA-5661039|Reactome:R-HSA-5661086 molecular_function owl:Class
GO:0031482 biolink:NamedThing myosin XII complex A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil. got7fsn_ti cellular_component owl:Class
GO:0050644 biolink:NamedThing cis-p-coumarate glucosyltransferase activity Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP. got7fsn_ti UDP-glucose:cis-p-coumarate beta-D-glucosyltransferase activity EC:2.4.1.209|RHEA:13129|MetaCyc:2.4.1.209-RXN|KEGG_REACTION:R05324 molecular_function owl:Class
GO:0060373 biolink:NamedThing regulation of ventricular cardiac muscle cell membrane depolarization Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a ventricular cardiomyocyte. got7fsn_ti regulation of ventricular cardiomyocyte membrane depolarization|electrocardiogram QRS complex|ventricular depolarization biological_process owl:Class
GO:0030166 biolink:NamedThing proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans. got7fsn_ti proteoglycan biosynthesis|proteoglycan anabolism|proteoglycan synthesis|proteoglycan formation biological_process owl:Class
GO:0034933 biolink:NamedThing 1-hydroxy-6-methoxypyrene methyltransferase activity Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX. got7fsn_ti UM-BBD_reactionID:r0956 molecular_function owl:Class
GO:0047501 biolink:NamedThing (+)-neomenthol dehydrogenase activity Catalysis of the reaction: (+)-neomenthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH. got7fsn_ti monoterpenoid dehydrogenase activity|(+)-neomenthol:NADP+ oxidoreductase activity RHEA:23812|MetaCyc:+-NEOMENTHOL-DEHYDROGENASE-RXN|EC:1.1.1.208|KEGG_REACTION:R02548 molecular_function owl:Class
GO:1990051 biolink:NamedThing activation of protein kinase C activity Any process that initiates the activity of the inactive enzyme protein kinase C. got7fsn_ti PKC activation|protein kinase C activation sl 2013-02-21T19:57:54Z biological_process owl:Class
GO:0072498 biolink:NamedThing embryonic skeletal joint development The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure. got7fsn_ti mah 2010-12-15T04:14:42Z biological_process owl:Class
GO:0102480 biolink:NamedThing 5-fluorocytosine deaminase activity Catalysis of the reaction: H+ + flucytosine + H2O <=> 5-fluorouracil + ammonium. got7fsn_ti MetaCyc:RXN-14129|EC:3.5.4.1 molecular_function owl:Class
GO:0009916 biolink:NamedThing alternative oxidase activity Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product. got7fsn_ti molecular_function owl:Class
GO:0050524 biolink:NamedThing coenzyme-B sulfoethylthiotransferase activity Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB. got7fsn_ti methyl coenzyme M reductase activity|methyl-coenzyme-M reductase activity|methyl-CoM reductase activity|2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreonine S-(2-sulfoethyl)thiotransferase activity|coenzyme-B sulphoethylthiotransferase activity GO:0018552 RHEA:12532|UM-BBD_reactionID:r0356|MetaCyc:METHYL-COM-HTP-RXN|EC:2.8.4.1|KEGG_REACTION:R04541 molecular_function owl:Class
GO:0016795 biolink:NamedThing phosphoric triester hydrolase activity Catalysis of the hydrolysis of a phosphoric triester. got7fsn_ti EC:3.1.8.- molecular_function owl:Class
GO:0042578 biolink:NamedThing phosphoric ester hydrolase activity Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. got7fsn_ti molecular_function owl:Class
GO:0042317 biolink:NamedThing penicillin catabolic process The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. got7fsn_ti penicillin catabolism|penicillin breakdown|penicillin degradation biological_process owl:Class
GO:1990930 biolink:NamedThing mRNA N1-methyladenosine dioxygenase activity Catalysis of the oxidative demethylation of N1-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenosine as formaldehyde. got7fsn_ti RNA N1-methyladenosine dioxygenase activity|RNA N(1)-methyladenosine dioxygenase activity https://github.com/geneontology/go-ontology/issues/21812 sp 2016-03-10T08:06:47Z RHEA:49516|EC:1.14.11.54 molecular_function owl:Class
GO:0030287 biolink:NamedThing cell wall-bounded periplasmic space The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria. got7fsn_ti cell wall-enclosed periplasmic space|cell wall bounded periplasmic space|IWZ|inner wall zone cellular_component owl:Class
GO:1900804 biolink:NamedThing brevianamide F catabolic process The chemical reactions and pathways resulting in the breakdown of brevianamide F. got7fsn_ti cyclo-L-Trp-L-Pro catabolism|tryptophan-proline diketopiperazine breakdown|cyclo-(Trp-Pro) breakdown|cyclo-L-tryptophanyl-L-proline breakdown|brevianamide F catabolism|L-prolyl-L-tryptophan anhydride degradation|L-prolyl-L-tryptophan anhydride catabolism|L-tryptophyl-L-proline cyclic anhydride breakdown|L-prolyl-L-tryptophan anhydride breakdown|cyclo-L-tryptophanyl-L-proline degradation|cyclo-L-Trp-L-Pro catabolic process|brevianamide F degradation|tryptophan-proline diketopiperazine catabolic process|cyclo-(Trp-Pro) catabolic process|tryptophan-proline diketopiperazine catabolism|cyclo-L-Trp-L-Pro breakdown|cyclo-L-Trp-L-Pro degradation|cyclo-L-tryptophanyl-L-proline catabolic process|tryptophan-proline diketopiperazine degradation|L-tryptophyl-L-proline cyclic anhydride catabolism|cyclo-L-tryptophanyl-L-proline catabolism|brevianamide F breakdown|L-tryptophyl-L-proline cyclic anhydride degradation|L-prolyl-L-tryptophan anhydride catabolic process|cyclo-(Trp-Pro) degradation|L-tryptophyl-L-proline cyclic anhydride catabolic process|cyclo-(Trp-Pro) catabolism di 2012-06-04T09:52:41Z biological_process owl:Class
GO:1900596 biolink:NamedThing (+)-kotanin biosynthetic process The chemical reactions and pathways resulting in the formation of (+)-kotanin. got7fsn_ti (+)-kotanin biosynthesis|(+)-kotanin synthesis|(+)-kotanin anabolism|(+)-kotanin formation di 2012-05-15T06:54:47Z biological_process owl:Class
GO:0046423 biolink:NamedThing allene-oxide cyclase activity Catalysis of the reaction: (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoate = (15Z)-12-oxophyto-10,15-dienoate. got7fsn_ti (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing) KEGG_REACTION:R03402|RHEA:22592|EC:5.3.99.6|MetaCyc:ALLENE-OXIDE-CYCLASE-RXN molecular_function owl:Class
GO:0018724 biolink:NamedThing 4-phenanthrol sulfotransferase activity Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate. got7fsn_ti 4-phenanthrol sulphotransferase activity UM-BBD_reactionID:r0562 molecular_function owl:Class
GO:0035457 biolink:NamedThing cellular response to interferon-alpha Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. got7fsn_ti cellular response to lymphoblastoid interferon|cellular response to interferon alfa-n3|cellular response to lymphoblast interferon|cellular response to interferon alfa-n1|cellular response to leukocyte interferon bf 2010-04-16T11:08:29Z biological_process owl:Class
GO:0018091 biolink:NamedThing peptidyl-asparagine racemization The racemization of peptidyl-asparagine. got7fsn_ti GO:0019127|GO:0018373 RESID:AA0196 biological_process owl:Class
GO:0002415 biolink:NamedThing immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa. got7fsn_ti immunoglobulin transcytosis mediated by pIgR|antibody transcytosis mediated by pIgR biological_process owl:Class
GO:0047534 biolink:NamedThing 2-acetolactate mutase activity Catalysis of the reaction: 2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate. got7fsn_ti acetolactate mutase activity|2-acetolactate methylmutase activity|acetohydroxy acid isomerase activity RHEA:16361|EC:5.4.99.3|MetaCyc:2-ACETOLACTATE-MUTASE-RXN molecular_function owl:Class
GO:0046693 biolink:NamedThing sperm storage The retention of sperm by a female following mating. got7fsn_ti storage of sperm|sequestering of sperm|sequestration of sperm|sperm sequestering|sperm retention|sperm sequestration|retention of sperm biological_process owl:Class
GO:0051940 biolink:NamedThing regulation of catecholamine uptake involved in synaptic transmission Any process that modulates the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. got7fsn_ti regulation of catecholamine neurotransmitter reuptake|regulation of catecholamine neurotransmitter uptake|regulation of catecholamine uptake during transmission of nerve impulse biological_process owl:Class
GO:0070742 biolink:NamedThing C2H2 zinc finger domain binding Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. got7fsn_ti mah 2009-06-23T11:26:02Z molecular_function owl:Class
GO:0061796 biolink:NamedThing membrane addition at site of mitotic cytokinesis A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion. got7fsn_ti dph 2016-10-05T12:06:11Z biological_process owl:Class
GO:0002081 biolink:NamedThing outer acrosomal membrane The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction. got7fsn_ti Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. cellular_component owl:Class
GO:0035906 biolink:NamedThing descending aorta development The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once. got7fsn_ti bf 2011-06-24T11:05:22Z biological_process owl:Class
GO:0036361 biolink:NamedThing racemase activity, acting on amino acids and derivatives Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative. got7fsn_ti bf 2012-09-21T11:13:47Z molecular_function owl:Class
GO:0018667 biolink:NamedThing cyclohexanone monooxygenase activity Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O. got7fsn_ti cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)|cyclohexanone 1,2-monooxygenase activity|cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity|cyclohexanone oxygenase activity EC:1.14.13.22|MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN|UM-BBD_reactionID:r0166|RHEA:24068 molecular_function owl:Class
GO:0018705 biolink:NamedThing 1,2-dichloroethene reductive dehalogenase activity Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride. got7fsn_ti 1,2-dichloroethylene reductive dehalogenase activity UM-BBD_enzymeID:e0272 molecular_function owl:Class
GO:0047502 biolink:NamedThing (+)-sabinol dehydrogenase activity Catalysis of the reaction: (+)-cis-sabinol + NAD(+) = (1S,5S)-sabinone + H(+) + NADH. got7fsn_ti (+)-cis-sabinol:NAD+ oxidoreductase activity|(+)-cis-sabinol dehydrogenase activity MetaCyc:+-SABINOL-DEHYDROGENASE-RXN|RHEA:18329|KEGG_REACTION:R03745|EC:1.1.1.228 molecular_function owl:Class
GO:0051309 biolink:NamedThing female meiosis chromosome separation The process in which paired chromosomes are physically detached from each other during female meiosis. got7fsn_ti female meiosis chromosome resolution|chromosome separation during female meiosis biological_process owl:Class
GO:0016321 biolink:NamedThing female meiosis chromosome segregation The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female. got7fsn_ti biological_process owl:Class
GO:0106340 biolink:NamedThing tRNA (guanosine 32-2'-O)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine 32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylguanosine 32 in tRNA. got7fsn_ti hjd 2020-11-05T22:52:49Z molecular_function owl:Class
GO:0004665 biolink:NamedThing prephenate dehydrogenase (NADP+) activity Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH. got7fsn_ti prephenate:NADP+ oxidoreductase (decarboxylating)|prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity RHEA:21640|KEGG_REACTION:R01730|EC:1.3.1.13|MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN molecular_function owl:Class
GO:1990643 biolink:NamedThing cellular response to granulocyte colony-stimulating factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus. got7fsn_ti sl 2015-02-11T19:22:44Z biological_process owl:Class
GO:0032166 biolink:NamedThing chlamydospore septin filament array Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation. got7fsn_ti cellular_component owl:Class
GO:0004346 biolink:NamedThing glucose-6-phosphatase activity Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate. got7fsn_ti D-glucose-6-phosphate phosphohydrolase activity|glucose 6-phosphate phosphatase activity RHEA:16689|KEGG_REACTION:R00303|Reactome:R-HSA-71825|Reactome:R-HSA-3282876|Reactome:R-HSA-3262512|Reactome:R-HSA-3266566|MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN|Reactome:R-HSA-3274540|EC:3.1.3.9 molecular_function owl:Class
GO:0005666 biolink:NamedThing RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. got7fsn_ti DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase III activity cellular_component owl:Class
GO:0002356 biolink:NamedThing peripheral B cell negative selection Any process leading to negative selection of B cells in the periphery. got7fsn_ti peripheral B lymphocyte negative selection|peripheral B-cell negative selection|peripheral B-lymphocyte negative selection biological_process owl:Class
GO:0004832 biolink:NamedThing valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+). got7fsn_ti valyl-transfer ribonucleic acid synthetase activity|L-valine:tRNAVal ligase (AMP-forming)|valine translase activity|valyl-transfer ribonucleate synthetase activity|valine transfer ribonucleate ligase activity|valyl-tRNA synthetase activity|valyl-transfer RNA synthetase activity EC:6.1.1.9|Reactome:R-HSA-380199|Reactome:R-HSA-380042|KEGG_REACTION:R03665|MetaCyc:VALINE--TRNA-LIGASE-RXN|RHEA:10704 molecular_function owl:Class
GO:0097603 biolink:NamedThing temperature-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism). got7fsn_ti heat-activated ion channel activity|temperature-activated ion channel activity|temperature gated ion channel activity|temperature-dependent ion channel activity pr 2014-05-12T13:10:42Z molecular_function owl:Class
GO:0000438 biolink:NamedThing core TFIIH complex portion of holo TFIIH complex The core TFIIH complex when it is part of the general transcription factor TFIIH. got7fsn_ti SSL2-core TFIIH complex portion of holo TFIIH complex GO:0000443 cellular_component owl:Class
GO:0046033 biolink:NamedThing AMP metabolic process The chemical reactions and pathways involving AMP, adenosine monophosphate. got7fsn_ti adenylate forming enzyme activity|AMP metabolism biological_process owl:Class
GO:0072230 biolink:NamedThing metanephric proximal straight tubule development The process whose specific outcome is the progression of the metanephric proximal straight tubule over time, from its formation to the mature structure. The metanephric proximal straight tubule is the part of the metanephric descending limb that extends from the metanephric proximal convoluted tubule to the metanephric descending thin tubule. got7fsn_ti metanephric S3 development mah 2010-03-18T03:38:53Z biological_process owl:Class
GO:0072020 biolink:NamedThing proximal straight tubule development The process whose specific outcome is the progression of the proximal straight tubule over time, from its formation to the mature structure. The proximal straight tubule is the part of the descending limb that extends from the proximal convoluted tubule to the descending thin tubule. got7fsn_ti S3 development mah 2010-01-25T02:36:14Z biological_process owl:Class
GO:1902093 biolink:NamedThing positive regulation of flagellated sperm motility Any process that activates or increases the frequency, rate or extent of flagellated sperm motility. got7fsn_ti up-regulation of sperm motility|up regulation of sperm movement|activation of sperm movement|activation of sperm motility|positive regulation of sperm movement|positive regulation of sperm motility|up regulation of sperm motility|up-regulation of sperm movement|upregulation of sperm motility|upregulation of sperm movement bf 2013-04-29T09:15:25Z biological_process owl:Class
GO:1901317 biolink:NamedThing regulation of flagellated sperm motility Any process that modulates the frequency, rate or extent of flagellated sperm motility. got7fsn_ti regulation of sperm motility|regulation of sperm movement hjd 2012-08-22T20:50:14Z biological_process owl:Class
GO:0047761 biolink:NamedThing butyrate kinase activity Catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H(+). got7fsn_ti ATP:butanoate 1-phosphotransferase activity MetaCyc:BUTYRATE-KINASE-RXN|KEGG_REACTION:R01688|RHEA:13585|EC:2.7.2.7 molecular_function owl:Class
GO:0004792 biolink:NamedThing thiosulfate sulfurtransferase activity Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate. got7fsn_ti rhodanese activity|thiosulfate:cyanide sulfurtransferase activity|rhodanase activity|thiosulphate sulphurtransferase activity|thiosulfate cyanide transsulfurase activity|thiosulfate thiotransferase activity MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN|KEGG_REACTION:R01931|EC:2.8.1.1|RHEA:16881|Reactome:R-HSA-9013198 molecular_function owl:Class
GO:0042262 biolink:NamedThing DNA protection Any process in which DNA is protected from damage by, for example, oxidative stress. got7fsn_ti biological_process owl:Class
GO:0010403 biolink:NamedThing pectic arabinogalactan I metabolic process The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I. got7fsn_ti pectic arabinogalactan I metabolism biological_process owl:Class
GO:0039621 biolink:NamedThing T=13 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres. got7fsn_ti bf 2012-07-18T02:18:59Z VZ:260 cellular_component owl:Class
GO:0034786 biolink:NamedThing 9-fluorenone-3,4-dioxygenase activity Catalysis of the reaction: 9-fluorenone + O2 + 2 H+ + 2 e- = 1-hydro-1,1a-dihydroxy-9-fluorenone. got7fsn_ti UM-BBD_reactionID:r1039 molecular_function owl:Class
GO:0070821 biolink:NamedThing tertiary granule membrane The lipid bilayer surrounding a tertiary granule. got7fsn_ti mah 2009-07-20T03:59:41Z cellular_component owl:Class
GO:0045430 biolink:NamedThing chalcone isomerase activity Catalysis of the reaction: a chalcone = a flavanone. got7fsn_ti chalcone-flavanone isomerase activity|chalcone--flavonone isomerase activity|flavanone lyase (decyclizing) MetaCyc:CHALCONE-ISOMERASE-RXN|EC:5.5.1.6 molecular_function owl:Class
GO:0034854 biolink:NamedThing 4,4-dimethyl-3-oxopentanoate decarboxylase activity Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2. got7fsn_ti UM-BBD_reactionID:r1280 molecular_function owl:Class
GO:0035709 biolink:NamedThing memory T cell activation The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti bf 2011-03-02T03:03:02Z biological_process owl:Class
GO:0097629 biolink:NamedThing extrinsic component of omegasome membrane The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to omegasome membrane|omegasome peripheral membrane cellular_component owl:Class
GO:0140396 biolink:NamedThing 5'-hydroxyaverantin dehydrogenase activity Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD(+) <=> 5'-oxoaverantin + NADH. got7fsn_ti pg 2019-11-29T08:56:49Z RHEA:35475|EC:1.1.1.352 molecular_function owl:Class
GO:0070671 biolink:NamedThing response to interleukin-12 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-12 stimulus. got7fsn_ti response to IL-12 mah 2009-05-29T10:02:31Z biological_process owl:Class
GO:0071286 biolink:NamedThing cellular response to magnesium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. got7fsn_ti mah 2009-12-10T04:05:50Z biological_process owl:Class
GO:0032026 biolink:NamedThing response to magnesium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus. got7fsn_ti biological_process owl:Class
GO:0032170 biolink:NamedThing pseudohyphal septin ring A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins. got7fsn_ti cellular_component owl:Class
GO:0080150 biolink:NamedThing S-adenosyl-L-methionine:benzoic acid carboxyl methyl transferase activity Catalysis of the reaction: benzoate + S-adenosyl-L-methionine = methylbenzoate + S-adenosyl-L-homocysteine. got7fsn_ti S-adenosyl-L-methionine:benzoate carboxyl methyltransferase activity dhl 2010-03-26T04:19:39Z RHEA:36099|MetaCyc:RXN-6722 molecular_function owl:Class
GO:0080172 biolink:NamedThing petal epidermis patterning The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the cells in the petal epidermis. got7fsn_ti dhl 2011-04-25T04:44:06Z biological_process owl:Class
GO:0009072 biolink:NamedThing aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). got7fsn_ti aromatic amino acid family metabolism biological_process owl:Class
GO:0043973 biolink:NamedThing histone H3-K4 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone. got7fsn_ti histone H3 acetylation at K4|histone H3K4 acetylation biological_process owl:Class
GO:0006476 biolink:NamedThing protein deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti protein amino acid deacetylation biological_process owl:Class
GO:1990247 biolink:NamedThing N6-methyladenosine-containing RNA binding Binding to an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. got7fsn_ti sp 2013-12-04T06:55:29Z molecular_function owl:Class
GO:0098650 biolink:NamedThing peptidyl-proline 4-dioxygenase binding Binding to a peptidyl-proline 4-dioxygenase. got7fsn_ti molecular_function owl:Class
GO:0044204 biolink:NamedThing host cell nuclear matrix The dense fibrillar network lying on the inner side of the host nuclear membrane. got7fsn_ti jl 2009-10-21T11:15:36Z cellular_component owl:Class
GO:0003356 biolink:NamedThing regulation of cilium beat frequency Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium. got7fsn_ti regulation of flagellum beat frequency|regulation of microtubule-based flagellum beat frequency Note that we deem cilium and microtubule-based flagellum to be equivalent. dph 2009-12-03T10:27:12Z GO:0036144 biological_process owl:Class
GO:0003352 biolink:NamedThing regulation of cilium movement Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. got7fsn_ti regulation of flagellum movement|regulation of flagellar movement|regulation of microtubule-based flagellum movement Note that we deem cilium and microtubule-based flagellum to be equivalent. dph 2009-12-03T10:12:00Z GO:1900172 biological_process owl:Class
GO:0052064 biolink:NamedThing induction by symbiont of defense-related host reactive oxygen species production The activation by a symbiont of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti activation by symbiont of defense-related host ROI production|induction by symbiont of defense-related host reactive oxidative species production|activation by symbiont of defense-related host respiratory burst|activation by symbiont of defense-related host reactive oxygen intermediate production|induction by symbiont of defense-related host metabolic burst|positive regulation by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction|upregulation by symbiont of defense-related host reactive oxygen species production|induction by symbiont of defense-related host oxidative burst|induction by organism of defense-related reactive oxygen species production in other organism involved in symbiotic interaction|stimulation by symbiont of defense-related host reactive oxygen species production|activation by symbiont of defense-related host metabolic burst|up-regulation by symbiont of defense-related host reactive oxygen species production|activation by symbiont of defense-related host reactive oxidative species production|up regulation by symbiont of defense-related host reactive oxygen species production|positive regulation by symbiont of defense-related host reactive oxygen species production|activation by symbiont of defense-related host ROS production|induction by symbiont of defense-related host AOS production|activation by symbiont of defense-related host reactive oxygen species production|activation by symbiont of defense-related host oxidative burst|induction by symbiont of defense-related reactive oxygen species production in other organism involved in symbiotic interaction|induction by symbiont of defense-related host active oxygen species production GO:0052369|GO:0052264|GO:0052348 biological_process owl:Class
GO:0000164 biolink:NamedThing protein phosphatase type 1 complex A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity. got7fsn_ti cellular_component owl:Class
GO:0102960 biolink:NamedThing momilactone-A synthase activity Catalysis of the reaction: 3beta-hydroxy-9beta-pimara-7,15-diene-19,6beta-olide + NAD(P) = momilactone A + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-9290|EC:1.1.1.295|RHEA:25367 molecular_function owl:Class
GO:0051211 biolink:NamedThing anisotropic cell growth The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell. got7fsn_ti non-isotropic cell growth biological_process owl:Class
GO:0047590 biolink:NamedThing 5-dehydro-2-deoxygluconokinase activity Catalysis of the reaction: ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. got7fsn_ti 5-keto-2-deoxyglucono kinase (phosphorylating)|DKH kinase activity|ATP:5-dehydro-2-deoxy-D-gluconate 6-phosphotransferase activity|5-keto-2-deoxygluconokinase activity RHEA:13497|MetaCyc:5-DEHYDRO-2-DEOXYGLUCONOKINASE-RXN|EC:2.7.1.92 molecular_function owl:Class
GO:0015016 biolink:NamedThing [heparan sulfate]-glucosamine N-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine. got7fsn_ti 3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity|3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity|heparin N-deacetylase/N-sulfotransferase activity|PAPS:N-desulfoheparin sulfotransferase activity|heparitin sulfotransferase activity|heparan sulfate N-deacetylase/N-sulfotransferase activity|[heparan sulphate]-glucosamine N-sulphotransferase activity|heparitin N-sulphotransferase activity|heparin-glucosamine N-sulfotransferase activity|N-HSST activity|N-heparan sulfate sulfotransferase activity|N-desulfoheparin sulfotransferase activity|heparitin N-sulfotransferase activity|PAPS:DSH sulfotransferase activity|3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity|3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity|heparan sulfate N-sulfotransferase activity|heparin N-deacetylase/N-sulphotransferase activity|heparan sulfate 2-N-sulfotransferase activity|heparin N-sulfotransferase activity|glucosaminyl N-deacetylase/N-sulfotransferase activity|desulfoheparin sulfotransferase activity Note that this activity includes EC:2.8.2.12 (deleted from EC). GO:0051910|GO:0004393|GO:0015022 Reactome:R-HSA-2022860|RHEA:21980|EC:2.8.2.8|MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN molecular_function owl:Class
GO:0001849 biolink:NamedThing complement component C1q complex binding Binding to a C1q complex, a component of the classical complement cascade. got7fsn_ti molecular_function owl:Class
GO:0046481 biolink:NamedThing digalactosyldiacylglycerol synthase activity Catalysis of the reaction: 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + UDP-D-galactose = 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-glycerol + H(+) + UDP. got7fsn_ti UDP-galactose-dependent DGDG synthase activity|DGD1|DGDG synthase activity|DGD2|UDP-galactose:MGDG galactosyltransferase activity|UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase activity|UDP-galactose-dependent digalactosyldiacylglycerol synthase activity EC:2.4.1.241|Wikipedia:Digalactosyldiacylglycerol_synthase|KEGG_REACTION:R04469|MetaCyc:RXN-1225|RHEA:10520 molecular_function owl:Class
GO:0018463 biolink:NamedThing 6-hydroxyhexanoate dehydrogenase activity Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH. got7fsn_ti 6-hydroxyhexanoate:NAD+ oxidoreductase activity MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN|RHEA:14225|EC:1.1.1.258|KEGG_REACTION:R05283|UM-BBD_reactionID:r0174 molecular_function owl:Class
GO:0047853 biolink:NamedThing difructose-anhydride synthase activity Catalysis of the reaction: H2O + bis-D-fructose 2',1:2,1'-dianhydride = inulobiose. got7fsn_ti inulobiose hydrolase activity|bis-D-fructose 2',1:2,1'-dianhydride fructohydrolase activity EC:3.2.1.134|MetaCyc:DIFRUCTOSE-ANHYDRIDE-SYNTHASE-RXN|RHEA:15041 molecular_function owl:Class
GO:0007302 biolink:NamedThing nurse cell nucleus anchoring Attachment of the nurse cell nucleus to the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0051647 biolink:NamedThing nucleus localization Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti nucleus localisation|cell nucleus localization|establishment and maintenance of nucleus localization|localization of nucleus biological_process owl:Class
GO:0080083 biolink:NamedThing beta-gentiobiose beta-glucosidase activity Catalysis of the hydrolysis of glucosidic link in beta-gentiobiose. got7fsn_ti dhl 2009-04-14T04:10:14Z molecular_function owl:Class
GO:0007113 biolink:NamedThing endomitotic cell cycle A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell. got7fsn_ti endomitosis Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. Wikipedia:Mitosis#Endomitosis biological_process owl:Class
GO:1990796 biolink:NamedThing photoreceptor cell terminal bouton A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light. got7fsn_ti sl 2015-07-09T21:33:40Z cellular_component owl:Class
GO:0006642 biolink:NamedThing triglyceride mobilization The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism. got7fsn_ti triacylglycerol mobilization biological_process owl:Class
GO:0006641 biolink:NamedThing triglyceride metabolic process The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins. got7fsn_ti triglyceride metabolism|triacylglycerol metabolic process|triacylglycerol metabolism biological_process owl:Class
GO:0034474 biolink:NamedThing U2 snRNA 3'-end processing Any process involved in forming the mature 3' end of a U2 snRNA molecule. got7fsn_ti U2 snRNA 3' end processing biological_process owl:Class
GO:0032579 biolink:NamedThing apical lamina of hyaline layer A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms. got7fsn_ti cellular_component owl:Class
GO:1901361 biolink:NamedThing organic cyclic compound catabolic process The chemical reactions and pathways resulting in the breakdown of organic cyclic compound. got7fsn_ti organic cyclic compound degradation|organic cyclic compound catabolism|organic cyclic compound breakdown bf 2012-09-14T09:05:04Z biological_process owl:Class
GO:0030570 biolink:NamedThing pectate lyase activity Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. got7fsn_ti pectate transeliminase activity|polygalacturonate lyase activity|PPase-N activity|endopectin methyltranseliminase activity|alpha-1,4-D-endopolygalacturonic acid lyase activity|polygalacturonic acid lyase activity|polygalacturonic transeliminase activity|pectin trans-eliminase activity|(1->4)-alpha-D-galacturonan lyase activity|polygalacturonic acid trans-eliminase activity|pectic acid transeliminase activity|pectic acid lyase activity|endogalacturonate transeliminase activity|endo-alpha-1,4-polygalacturonic acid lyase activity|PGA lyase activity|pectic lyase activity MetaCyc:4.2.2.2-RXN|EC:4.2.2.2 molecular_function owl:Class
GO:0003942 biolink:NamedThing N-acetyl-gamma-glutamyl-phosphate reductase activity Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. got7fsn_ti N-acetylglutamic gamma-semialdehyde dehydrogenase activity|reductase, acetyl-gamma-glutamyl phosphate|N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)|N-acetylglutamate 5-semialdehyde dehydrogenase activity|N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)|NAGSA dehydrogenase activity|N-acetyl-glutamate semialdehyde dehydrogenase activity RHEA:21588|MetaCyc:N-ACETYLGLUTPREDUCT-RXN|EC:1.2.1.38 molecular_function owl:Class
GO:0017014 biolink:NamedThing protein nitrosylation The covalent addition of a nitric oxide group to an amino acid within a protein. got7fsn_ti protein amino acid nitrosylation biological_process owl:Class
GO:0008716 biolink:NamedThing D-alanine-D-alanine ligase activity Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate. got7fsn_ti D-Ala-D-Ala synthetase activity|D-alanyl-D-alanine synthetase activity|D-alanylalanine synthetase activity|alanine:alanine ligase (ADP-forming) activity|D-alanine:D-alanine ligase (ADP-forming)|alanylalanine synthetase activity MetaCyc:DALADALALIG-RXN|RHEA:11224|EC:6.3.2.4|KEGG_REACTION:R01150 molecular_function owl:Class
GO:0018407 biolink:NamedThing peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine). got7fsn_ti peptidyl-thyronine iodination to form triiodothyronine RESID:AA0177 biological_process owl:Class
GO:0050133 biolink:NamedThing N6-hydroxylysine O-acetyltransferase activity Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA. got7fsn_ti N6-hydroxylysine acetylase activity|N(6)-hydroxylysine acetylase activity|acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase activity|N6-hydroxylysine:acetyl CoA N6-transacetylase activity|acetyl-CoA:6-N-hydroxy-L-lysine 6-acetyltransferase activity KEGG_REACTION:R03168|MetaCyc:N6-HYDROXYLYSINE-O-ACETYLTRANSFERASE-RXN|RHEA:22388|EC:2.3.1.102 molecular_function owl:Class
GO:0002481 biolink:NamedThing antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. got7fsn_ti TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib|exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent|TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib biological_process owl:Class
GO:0047700 biolink:NamedThing beta-glucoside kinase activity Catalysis of the reaction: ATP + cellobiose = ADP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose. got7fsn_ti beta-D-glucoside kinase (phosphorylating)|b-glucoside kinase activity|ATP:cellobiose 6-phosphotransferase activity EC:2.7.1.85|MetaCyc:BETA-GLUCOSIDE-KINASE-RXN|RHEA:21944 molecular_function owl:Class
GO:0102985 biolink:NamedThing delta12-fatty-acid desaturase activity Catalysis of the reaction: oleoyl-CoA + O2 + a reduced electron acceptor <=> linoleoyl-CoA + 2 H2O + an oxidized electron acceptor. This microsomal enzyme introduces a cis double bond at position 12 of fatty-acyl-CoAs that contain a cis double bond at position 9. got7fsn_ti RHEA:25856|MetaCyc:RXN-9601|EC:1.14.19.6 molecular_function owl:Class
GO:0061786 biolink:NamedThing peptidoglycan stem peptide endopeptidase activity A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan. got7fsn_ti dph 2016-09-07T16:47:04Z molecular_function owl:Class
GO:0052654 biolink:NamedThing L-leucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamatic acid. got7fsn_ti L-leucine aminotransferase activity MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN|EC:2.6.1.42|KEGG_REACTION:R01090 molecular_function owl:Class
GO:0008849 biolink:NamedThing enterochelin esterase activity Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+. got7fsn_ti enterobactin esterase activity MetaCyc:RXN0-1661|RHEA:28018 molecular_function owl:Class
GO:0102414 biolink:NamedThing quercetin-3-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin-3-gentiobioside + UDP. got7fsn_ti MetaCyc:RXN-13797 molecular_function owl:Class
GO:0102703 biolink:NamedThing camphene synthase activity Catalysis of the reaction: geranyl diphosphate <=> (-)-camphene + diphosphoric acid. got7fsn_ti RHEA:25484|EC:4.2.3.117|MetaCyc:RXN-5142 molecular_function owl:Class
GO:0045341 biolink:NamedThing MHC class I biosynthetic process The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I. got7fsn_ti MHC class I anabolism|MHC class I synthesis|major histocompatibility complex class I biosynthetic process|major histocompatibility complex class I biosynthesis|MHC class I formation|MHC class I biosynthesis biological_process owl:Class
GO:0021665 biolink:NamedThing rhombomere 5 structural organization The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 5 structural organisation biological_process owl:Class
GO:0043965 biolink:NamedThing suppression by symbiont of host adenylate cyclase-mediated signal transduction Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of host adenylate cyclase-mediated signal transduction biological_process owl:Class
GO:0015849 biolink:NamedThing organic acid transport The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0060909 biolink:NamedThing regulation of DNA replication initiation involved in plasmid copy number maintenance Any process that modulates the frequency, rate or extent of initiation of plasmid DNA replication that contributes to copy number maintenance. got7fsn_ti dph 2009-09-04T02:51:48Z biological_process owl:Class
GO:0008437 biolink:NamedThing thyrotropin-releasing hormone activity The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary. got7fsn_ti thyrotropin releasing hormone activity|TRH activity molecular_function owl:Class
GO:0043903 biolink:NamedThing regulation of biological process involved in symbiotic interaction Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association. got7fsn_ti regulation of symbiotic process|regulation of symbiosis, encompassing mutualism through parasitism|regulation of interspecies interactions between organisms https://github.com/geneontology/go-ontology/issues/20191|https://github.com/geneontology/go-ontology/issues/19028 regulation of interspecies interactions between organisms biological_process owl:Class
GO:0035408 biolink:NamedThing histone H3-T6 phosphorylation The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone. got7fsn_ti bf 2010-03-24T10:12:51Z biological_process owl:Class
GO:0033094 biolink:NamedThing butane-1,4-diamine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O. got7fsn_ti PAT activity|putrescine:alpha-ketoglutarate aminotransferase activity|putrescine-alpha-ketoglutarate transaminase activity|putrescine aminotransferase activity|putrescine transaminase activity|putrescine:2-oxoglutarate aminotransferase activity|YgjG EC:2.6.1.82|RHEA:12268|MetaCyc:2.6.1.82-RXN molecular_function owl:Class
GO:0036139 biolink:NamedThing peptidyl-histidine dioxygenase activity Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2. got7fsn_ti bf 2012-03-07T09:26:54Z molecular_function owl:Class
GO:0097408 biolink:NamedThing fibrillary inclusion Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra. got7fsn_ti pr 2012-10-31T13:53:58Z NIF_Subcellular:sao967812059 cellular_component owl:Class
GO:0035882 biolink:NamedThing defecation rhythm The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated. got7fsn_ti DMP|defecation behavior|defecation cycle|defecation motor program bf 2011-06-06T11:36:35Z biological_process owl:Class
GO:0047115 biolink:NamedThing trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol. got7fsn_ti dihydrodiol dehydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase activity EC:1.3.1.20|MetaCyc:1.3.1.20-RXN|RHEA:16729 molecular_function owl:Class
GO:0003830 biolink:NamedThing beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. got7fsn_ti beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity|GnTIII activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity|uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III|uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity|N-acetylglucosaminyltransferase III activity|UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity|beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity MetaCyc:2.4.1.144-RXN|RHEA:15509|EC:2.4.1.144|Reactome:R-HSA-975926 molecular_function owl:Class
GO:0102693 biolink:NamedThing UDP-glucose:kinetin 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + kinetin <=> H+ + kinetin-7-N-glucoside + UDP. got7fsn_ti MetaCyc:RXN-4731 molecular_function owl:Class
GO:0102374 biolink:NamedThing ursolic aldehyde 28-monooxygenase activity Catalysis of the reaction: ursolic aldehyde + NADPH + O2 + H+ <=> ursolic acid + NADP + H2O. got7fsn_ti EC:1.14.14.126|MetaCyc:RXN-13502 molecular_function owl:Class
GO:0097132 biolink:NamedThing cyclin D2-CDK6 complex A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:56:34Z cellular_component owl:Class
GO:0006207 biolink:NamedThing 'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. got7fsn_ti 'de novo' pyrimidine base synthesis|'de novo' pyrimidine base formation|'de novo' pyrimidine base anabolism|'de novo' pyrimidine base biosynthesis|'de novo' pyrimidine base biosynthetic process biological_process owl:Class
GO:0019856 biolink:NamedThing pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. got7fsn_ti pyrimidine base synthesis|pyrimidine base biosynthetic process|pyrimidine base biosynthesis|pyrimidine base anabolism|pyrimidine base formation biological_process owl:Class
GO:0050139 biolink:NamedThing nicotinate-N-glucosyltransferase activity Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP. got7fsn_ti nicotinate glucosyltransferase activity|UDP-glucose:nicotinic acid-N-glucosyltransferase activity|UDP-glucose:nicotinate N-glucosyltransferase activity|uridine diphosphoglucose-nicotinate N-glucosyltransferase activity|UDPglucose:nicotinate N-glucosyltransferase activity MetaCyc:NICOTINATE-GLUCOSYLTRANSFERASE-RXN|KEGG_REACTION:R01722|RHEA:19437|EC:2.4.1.196 molecular_function owl:Class
GO:0035483 biolink:NamedThing gastric emptying The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum. got7fsn_ti bf 2010-04-23T10:51:33Z biological_process owl:Class
GO:0090470 biolink:NamedThing shoot organ boundary specification The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained. got7fsn_ti tb 2012-09-24T16:22:03Z biological_process owl:Class
GO:0032152 biolink:NamedThing meiotic septin complex A heterooligomeric septin complex that acts during meiotic cell division. got7fsn_ti cellular_component owl:Class
GO:0050356 biolink:NamedThing tropine dehydrogenase activity Catalysis of the reaction: NADP(+) + tropine = H(+) + NADPH + tropinone. got7fsn_ti tropine:NADP+ 3alpha-oxidoreductase activity MetaCyc:TROPINE-DEHYDROGENASE-RXN|RHEA:18357|EC:1.1.1.206|KEGG_REACTION:R02832 molecular_function owl:Class
GO:0044029 biolink:NamedThing hypomethylation of CpG island An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. got7fsn_ti DNA hypomethylation of CpG island biological_process owl:Class
GO:0052633 biolink:NamedThing isocitrate hydro-lyase (cis-aconitate-forming) activity Catalysis of the reaction: cis-aconitate + H2O = isocitrate. got7fsn_ti citrate(isocitrate) hydro-lyase activity|citrate hydro-lyase activity|citrate(isocitrate) hydro-lyase (cis-aconitate-forming)|aconitate hydratase activity|cis-aconitase activity MetaCyc:ACONITATEHYDR-RXN|KEGG_REACTION:R01900|RHEA:22144 molecular_function owl:Class
GO:0060999 biolink:NamedThing positive regulation of dendritic spine development Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. got7fsn_ti dph 2010-01-20T09:27:21Z biological_process owl:Class
GO:0046408 biolink:NamedThing chlorophyll synthetase activity Catalysis of the reaction: chlorophyllide a + 2 H(+) + phytyl diphosphate = chlorophyll a + diphosphate. got7fsn_ti chlorophyllide-a:phytyl-diphosphate phytyltransferase activity|chlorophyll synthase activity GO:0043787 MetaCyc:RXN1F-66|EC:2.5.1.62|KEGG_REACTION:R06284|RHEA:17317 molecular_function owl:Class
GO:0015272 biolink:NamedThing ATP-activated inward rectifier potassium channel activity Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. got7fsn_ti Reactome:R-HSA-5683209 molecular_function owl:Class
GO:0047403 biolink:NamedThing lacto-N-biosidase activity Catalysis of the reaction: H2O + beta-D-Gal-(1,3)-beta-D-GlcNAc-(1,3)-beta-D-Gal-(1,4)-D-Glc = beta-D-Gal-(1,4)-D-Glc + beta-D-Gal-(1,3)-D-GlcNAc. got7fsn_ti oligosaccharide lacto-N-biosylhydrolase activity RHEA:21568|EC:3.2.1.140 molecular_function owl:Class
GO:0050157 biolink:NamedThing ornithine racemase activity Catalysis of the reaction: L-ornithine = D-ornithine. got7fsn_ti RHEA:11584|EC:5.1.1.12|MetaCyc:ORNITHINE-RACEMASE-RXN molecular_function owl:Class
GO:0018684 biolink:NamedThing 2,5-diketocamphane 1,2-monooxygenase Catalysis of the reaction: 1R,4R)-bornane-2,5-dione + FMNH2 + O2 = (1R,4R)-5-oxo-1,2-campholide + FMN + H+ + H2O. got7fsn_ti camphor ketolactonase I activity|(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)|2,5-diketocamphane lactonizing enzyme activity|camphor 1,2-monooxygenase activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.14.15.2. EC:1.14.14.108|MetaCyc:CAMPHOR-12-MONOOXYGENASE-RXN|RHEA:34415|UM-BBD_enzymeID:e0302 molecular_function owl:Class
GO:0000395 biolink:NamedThing mRNA 5'-splice site recognition Recognition of the intron 5'-splice site by components of the assembling spliceosome. got7fsn_ti spliceosomal CC complex formation|U12-type nuclear mRNA 5' splice site recognition|spliceosomal E complex formation|spliceosomal commitment complex biosynthesis|U2-type nuclear mRNA 5'-splice site recognition|spliceosomal commitment complex formation|U2-type nuclear mRNA 5' splice site recognition|nuclear mRNA 5' splice site recognition|spliceosomal E complex biosynthesis|U12-type nuclear mRNA 5'-splice site recognition|spliceosomal CC complex biosynthesis|nuclear mRNA 5'-splice site recognition Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian). GO:0000368|GO:0000369 biological_process owl:Class
GO:0061995 biolink:NamedThing ATP-dependent protein-DNA complex displacement activity An activity that displaces proteins or protein complexes from DNA, sometimes in a 'wire stripping' fashion, driven by ATP hydrolysis. got7fsn_ti ATP-dependent protein-nucleic acid complex displacement activity https://github.com/geneontology/go-ontology/issues/21612 dph 2018-02-16T15:46:47Z GO:0061994 molecular_function owl:Class
GO:0071588 biolink:NamedThing hydrogen peroxide mediated signaling pathway A series of molecular signals mediated by the detection of hydrogen peroxide (H2O2). got7fsn_ti H2O2 mediated signaling pathway|hydrogen peroxide mediated signalling pathway mah 2010-01-29T11:18:58Z biological_process owl:Class
GO:0070732 biolink:NamedThing spindle envelope An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase. got7fsn_ti mah 2009-06-18T12:00:59Z cellular_component owl:Class
GO:0008789 biolink:NamedThing altronate dehydratase activity Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O. got7fsn_ti D-altronate hydro-lyase activity|D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming) KEGG_REACTION:R01540|RHEA:15957|EC:4.2.1.7|MetaCyc:ALTRODEHYDRAT-RXN molecular_function owl:Class
GO:0060858 biolink:NamedThing vesicle-mediated transport involved in floral organ abscission The directed movement of substances within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane which are then targeted to, and fuse with, an acceptor membrane contributing to the shedding of a floral organ. got7fsn_ti membrane trafficking involved in floral organ shedding dph 2009-08-12T03:48:54Z biological_process owl:Class
GO:0002953 biolink:NamedThing 5'-deoxynucleotidase activity Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate. got7fsn_ti molecular_function owl:Class
GO:0004836 biolink:NamedThing tyramine-beta hydroxylase activity Catalysis of the hydroxylation of tyramine to form octopamine. got7fsn_ti molecular_function owl:Class
GO:0035627 biolink:NamedThing ceramide transport The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid. got7fsn_ti bf 2010-12-10T10:02:16Z biological_process owl:Class
GO:0032636 biolink:NamedThing interleukin-7 production The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-7 secretion|IL-7 production|interleukin-7 biosynthetic process GO:0042227|GO:0072605 biological_process owl:Class
GO:0071959 biolink:NamedThing maintenance of mitotic sister chromatid cohesion, arms The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. got7fsn_ti maintenance of mitotic sister chromatin cohesion along arms|maintenance of sister chromatin cohesion along arms at mitosis mah 2011-06-01T04:08:43Z biological_process owl:Class
GO:0050609 biolink:NamedThing phosphonate dehydrogenase activity Catalysis of the reaction: H(2)O + NAD(+) + phosphonate = 2 H(+) + NADH + phosphate. got7fsn_ti phosphonate:NAD+ oxidoreductase activity|NAD:phosphite oxidoreductase activity|NAD-dependent phosphite dehydrogenas activity|phosphite dehydrogenase activity RHEA:13173|MetaCyc:1.20.1.1-RXN|EC:1.20.1.1|KEGG_REACTION:R05746|UM-BBD_reactionID:r1055 molecular_function owl:Class
GO:0051596 biolink:NamedThing methylglyoxal catabolic process The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid. got7fsn_ti methylglyoxal catabolism|methylglyoxal breakdown|methylglyoxal degradation MetaCyc:Methylglyoxal-Detoxification|MetaCyc:METHGLYUT-PWY biological_process owl:Class
GO:0044774 biolink:NamedThing mitotic DNA integrity checkpoint signaling A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during mitosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. got7fsn_ti intracellular signaling cascade involved in mitotic DNA integrity checkpoint|signal transduction involved in mitotic DNA integrity checkpoint|intracellular signal transduction involved in topo II checkpoint|intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint|signal transduction via intracellular signaling cascade involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signaling chain involved in mitotic DNA integrity checkpoint|intracellular signaling cascade involved in topo II checkpoint|mitotic DNA integrity checkpoint|intracellular signaling pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signal transduction involved in mitotic cell cycle G2/M transition decatenation checkpoint|signal transduction via intracellular signaling cascade involved in topo II checkpoint|intracellular signaling pathway involved in mitotic DNA integrity checkpoint|intracellular signal transduction pathway involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signal transduction pathway involved in mitotic DNA integrity checkpoint|intracellular signal transduction pathway involved in topo II checkpoint|mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signal transduction pathway involved in topoisomerase II checkpoint|intracellular signaling chain involved in mitotic cell cycle G2/M transition decatenation checkpoint|intracellular signaling pathway involved in topoisomerase II checkpoint|intracellular signaling pathway involved in topo II checkpoint jl 2013-02-28T16:07:26Z GO:0070683|GO:1902403 biological_process owl:Class
GO:0047801 biolink:NamedThing L-cysteine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-cysteine + 2-oxoglutarate = mercaptopyruvate + L-glutamate. got7fsn_ti L-cysteine aminotransferase activity|cysteine transaminase activity|CGT|cysteine aminotransferase activity RHEA:17441|MetaCyc:CYSTEINE-AMINOTRANSFERASE-RXN|EC:2.6.1.3|Reactome:R-HSA-9012597 molecular_function owl:Class
GO:0005714 biolink:NamedThing early recombination nodule An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I. got7fsn_ti cellular_component owl:Class
GO:0008939 biolink:NamedThing nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate. got7fsn_ti nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity|CobT|N(1)-alpha-phosphoribosyltransferase activity|N1-alpha-phosphoribosyltransferase activity|nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity|nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity|nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity|nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity RHEA:11196|MetaCyc:DMBPPRIBOSYLTRANS-RXN|KEGG_REACTION:R04148|EC:2.4.2.21 molecular_function owl:Class
GO:0000762 biolink:NamedThing pheromone-induced unidirectional conjugation The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. got7fsn_ti biological_process owl:Class
GO:0071539 biolink:NamedThing protein localization to centrosome A process in which a protein is transported to, or maintained at, the centrosome. got7fsn_ti protein localisation to centrosome mah 2010-01-12T02:09:45Z biological_process owl:Class
GO:0072629 biolink:NamedThing interleukin-28B production The appearance of interleukin-28B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL28B production|interleukin-28B secretion|interferon lambda 3 production|IL-28B production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072630 biological_process owl:Class
GO:0060732 biolink:NamedThing positive regulation of inositol phosphate biosynthetic process Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. got7fsn_ti dph 2009-06-12T01:58:23Z biological_process owl:Class
GO:1990650 biolink:NamedThing inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate. got7fsn_ti al 2015-02-23T11:14:17Z molecular_function owl:Class
GO:0000388 biolink:NamedThing spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11). got7fsn_ti 3'-splice site cleavage, exon ligation|U12-type spliceosome conformational change to release U4atac and U11|spliceosomal B2 complex formation|spliceosomal A1 complex biosynthesis|spliceosomal A1 complex formation|spliceosomal B2 complex biosynthesis|U2-type spliceosome conformational change to release U4 and U1 Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian). GO:0000396|GO:0000397 biological_process owl:Class
GO:0060870 biolink:NamedThing cell wall disassembly involved in floral organ abscission A cellular process that results in the breakdown of the cell wall that contributes to the process of floral organ abscission. got7fsn_ti dph 2009-08-12T07:15:36Z biological_process owl:Class
GO:0047144 biolink:NamedThing 2-acylglycerol-3-phosphate O-acyltransferase activity Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA. got7fsn_ti acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase activity|2-acylglycerophosphate acyltransferase activity Reactome:R-HSA-1482691|Reactome:R-HSA-1482533|Reactome:R-HSA-1482646|Reactome:R-HSA-1482546|MetaCyc:2-ACYL2.3.1.15-RXN|Reactome:R-HSA-1482626|Reactome:R-HSA-1482635|RHEA:14233|EC:2.3.1.52 molecular_function owl:Class
GO:0004359 biolink:NamedThing glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. got7fsn_ti L-glutaminase activity|glutamine aminohydrolase activity|L-glutamine amidohydrolase activity|glutaminase I RHEA:15889|Reactome:R-HSA-70609|MetaCyc:GLUTAMIN-RXN|EC:3.5.1.2 molecular_function owl:Class
GO:0071122 biolink:NamedThing alpha9-beta1 integrin-VEGF-A complex A protein complex that consists of an alpha9-beta1 integrin complex bound to vascular endothelial growth factor A. got7fsn_ti ITGA9-ITGB1-VEGFA complex mah 2009-11-13T02:22:01Z cellular_component owl:Class
GO:0003113 biolink:NamedThing positive regulation of heart rate by neuronal norepinephrine The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction. got7fsn_ti positive regulation of heart rate by neuronal noradrenaline biological_process owl:Class
GO:0047450 biolink:NamedThing crotonoyl-[acyl-carrier-protein] hydratase activity Catalysis of the reaction: (3R)-3-hydroxybutanoyl-[acyl-carrier protein] = H2O + but-2-enoyl-[acyl-carrier protein]. got7fsn_ti crotonoyl-[acyl-carrier protein] hydratase activity|(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase activity|(3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydro-lyase activity|3-hydroxybutyryl acyl carrier protein dehydratase activity|enoyl acyl carrier protein hydrase activity|(3R)-3-hydroxybutanoyl-acyl-carrier-protein hydro-lyase (but-2-enoyl-acyl-carrier protein-forming)|beta-hydroxybutyryl acyl carrier protein dehydrase activity|beta-hydroxybutyryl acyl carrier protein (ACP) dehydrase activity|crotonoyl-acyl-carrier-protein hydratase activity|crotonyl acyl carrier protein hydratase activity|crotonoyl-ACP hydratase activity GO:0080063 EC:4.2.1.58|KEGG_REACTION:R04428|MetaCyc:4.2.1.58-RXN molecular_function owl:Class
GO:0007023 biolink:NamedThing post-chaperonin tubulin folding pathway Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors. got7fsn_ti biological_process owl:Class
GO:0090078 biolink:NamedThing smooth muscle derived foam cell differentiation The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. got7fsn_ti tb 2009-09-15T03:48:10Z biological_process owl:Class
GO:0102798 biolink:NamedThing heptaldehyde:oxygen oxidoreductase activity Catalysis of the reaction: heptanal + O2 + H2O = H+ + heptanoate + hydrogen peroxide. got7fsn_ti EC:1.2.3.1|MetaCyc:RXN-8094 molecular_function owl:Class
GO:0034722 biolink:NamedThing gamma-glutamyl-peptidase activity Catalysis of the cleavage of a gamma-linked glutamate bond. got7fsn_ti gamma-glutamyl hydrolase activity EC:3.4.19.9|RHEA:56784|MetaCyc:3.4.19.9-RXN molecular_function owl:Class
GO:1990280 biolink:NamedThing RNA localization to chromatin A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin. got7fsn_ti RNA localisation to chromatin mah 2014-01-30T15:55:34Z biological_process owl:Class
GO:1900116 biolink:NamedThing extracellular negative regulation of signal transduction Any negative regulation of signal transduction that takes place in extracellular region. got7fsn_ti inhibition of signal transduction in extracellular region|down-regulation of signal transduction in extracellular region|negative regulation of signalling pathway in extracellular region|negative regulation of signaling pathway in extracellular region|extracellular inhibition of signaling pathway|down regulation of signal transduction in extracellular region|downregulation of signal transduction in extracellular region bf 2012-02-22T10:27:56Z biological_process owl:Class
GO:0050398 biolink:NamedThing wax-ester hydrolase activity Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate. got7fsn_ti wax-ester acylhydrolase activity|jojoba wax esterase|WEH MetaCyc:WAX-ESTER-HYDROLASE-RXN|EC:3.1.1.50|RHEA:13577 molecular_function owl:Class
GO:0071796 biolink:NamedThing K6-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 6 in the target protein. got7fsn_ti mah 2010-09-02T02:13:07Z molecular_function owl:Class
GO:1990323 biolink:NamedThing collagen type XXIV trimer A collagen homotrimer of alpha1(XXIV) chains; type XXIV collagen triple helices may participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development. got7fsn_ti bhm 2014-03-14T22:05:53Z cellular_component owl:Class
GO:0052901 biolink:NamedThing spermine:oxygen oxidoreductase (spermidine-forming) activity Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine. got7fsn_ti spermine oxidase activity|polyamine oxidase activity|non-specific polyamine oxidase activity|N(1)-acetylpolyamine oxidase activity EC:1.5.3.17|RHEA:25804|Reactome:R-HSA-141341|MetaCyc:RXN-9015|MetaCyc:1.5.3.17-RXN|EC:1.5.3.13|KEGG_REACTION:R09076|EC:1.5.3.16 molecular_function owl:Class
GO:0010609 biolink:NamedThing mRNA localization resulting in posttranscriptional regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell. got7fsn_ti posttranscriptional regulation of gene expression by mRNA localisation|mRNA localisation resulting in posttranscriptional regulation of gene expression|posttranscriptional regulation of gene expression by mRNA localization biological_process owl:Class
GO:0019773 biolink:NamedThing proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. got7fsn_ti cellular_component owl:Class
GO:0098594 biolink:NamedThing mucin granule A secretory granule that contains mucin. got7fsn_ti dos 2014-03-11T15:59:11Z cellular_component owl:Class
GO:1990798 biolink:NamedThing pancreas regeneration The regrowth of a destroyed pancreas. got7fsn_ti sl 2015-07-10T22:53:53Z biological_process owl:Class
GO:1990764 biolink:NamedThing myofibroblast contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast. got7fsn_ti MF contraction|MFB contraction sl 2015-06-09T23:43:09Z biological_process owl:Class
GO:0102634 biolink:NamedThing 1,3,6,8-tetrahydroxynaphthalene monooxygenase (quinone-forming) activity Catalysis of the reaction: naphthalene-1,3,6,8-tetrol + O2 <=> flaviolin-2-olate + H2O + H+. got7fsn_ti MetaCyc:RXN-15586 molecular_function owl:Class
GO:0034937 biolink:NamedThing perchlorate reductase activity Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O. got7fsn_ti EC:1.97.1.-|UM-BBD_reactionID:r0980 molecular_function owl:Class
GO:0008987 biolink:NamedThing quinolinate synthetase A activity Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate. got7fsn_ti MetaCyc:QUINOLINATE-SYNTHA-RXN|RHEA:25888 molecular_function owl:Class
GO:0035938 biolink:NamedThing estradiol secretion The regulated release of estradiol into the circulatory system. got7fsn_ti oestradiol secretion bf 2011-07-20T01:16:45Z biological_process owl:Class
GO:0004980 biolink:NamedThing melanocyte-stimulating hormone receptor activity Combining with melanocyte-stimulating hormone to initiate a change in cell activity. got7fsn_ti melanophore-stimulating hormone receptor activity|MSH receptor activity|MSHR activity|melanocyte stimulating hormone receptor activity molecular_function owl:Class
GO:0072547 biolink:NamedThing tricoumaroylspermidine meta-hydroxylase activity Catalysis of the reaction: tricoumaroyl spermidine + NADPH + O2 = dicoumaroyl monocaffeoyl spermidine + NADP+ + H2O. got7fsn_ti tricoumaroyl spermidine meta-hydroxylase activity mah 2011-01-25T02:49:37Z MetaCyc:RXN-11260 molecular_function owl:Class
GO:0080005 biolink:NamedThing photosystem stoichiometry adjustment Adjustment of Photosystem I/Photosystem II ratio in response to light conditions. The function of photosystem stoichiometry adjustment is to compensate for any deficiency in energy conversion at either photosystem I or photosystem II by increasing the quantity the photosystem that will otherwise become the rate-limiting to overall photosynthesis. got7fsn_ti biological_process owl:Class
GO:0010109 biolink:NamedThing regulation of photosynthesis Any process that modulates the frequency, rate or extent of photosynthesis. got7fsn_ti biological_process owl:Class
GO:0036077 biolink:NamedThing intratendonous ossification Ossification wherein bone tissue forms within tendonous tissue. got7fsn_ti Tendonous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance. bf 2011-12-19T01:57:48Z biological_process owl:Class
GO:0014035 biolink:NamedThing neural crest cell fate determination The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0055042 biolink:NamedThing 5-valerolactone hydrolase activity Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate. got7fsn_ti molecular_function owl:Class
GO:0034547 biolink:NamedThing N-cyclopropylmelamine deaminase activity Catalysis of the reaction: cyromazine + H2O = N-cyclopropylammeline + NH3. got7fsn_ti UM-BBD_reactionID:r0825|MetaCyc:RXN-8018 molecular_function owl:Class
GO:0042747 biolink:NamedThing circadian sleep/wake cycle, REM sleep A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity. got7fsn_ti biological_process owl:Class
GO:0098763 biolink:NamedThing mitotic cell cycle phase One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. got7fsn_ti This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0010055 biolink:NamedThing atrichoblast differentiation The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair. got7fsn_ti biological_process owl:Class
GO:0097353 biolink:NamedThing centrolateral pattern formation The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment. got7fsn_ti mediolateral pattern formation pr 2012-07-02T11:34:08Z biological_process owl:Class
GO:0103035 biolink:NamedThing NAD(P)H:methyl-1,4-benzoquinone oxidoreductase activity Catalysis of the reaction: 3 H+ + methyl-1,4-benzoquinone + NADPH = methyl-1,4-benzoquinol + NADP. got7fsn_ti MetaCyc:RXN0-5387 molecular_function owl:Class
GO:0004065 biolink:NamedThing arylsulfatase activity Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. got7fsn_ti sulfatase activity|estrogen sulfatase activity|p-nitrophenyl sulfatase activity|phenolsulfatase activity|phenylsulfatase activity|aryl-sulfate sulfohydrolase activity|aryl-sulfate sulphohydrolase activity|arylsulphatase activity|nitrocatechol sulfatase activity|aryl-sulphate sulphohydrolase activity|4-methylumbelliferyl sulfatase activity|arylsulfohydrolase activity MetaCyc:ARYLSULFAT-RXN|EC:3.1.6.1|RHEA:17261 molecular_function owl:Class
GO:0046723 biolink:NamedThing malic acid secretion The controlled release of malic acid, hydroxybutanedioic (hydroxysuccinic) acid, by a cell or a tissue. got7fsn_ti hydroxysuccinic acid secretion|malate secretion biological_process owl:Class
GO:0071969 biolink:NamedThing fungal-type cell wall (1->3)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of fungi. got7fsn_ti fungal-type cell wall 1,3-beta-glucan metabolism|fungal-type cell wall beta-1,3 glucan metabolism|fungal-type cell wall beta-1,3 glucan metabolic process|fungal-type cell wall 1,3-beta-D-glucan metabolic process mah 2010-10-18T03:25:38Z biological_process owl:Class
GO:0097022 biolink:NamedThing lymphocyte migration into lymph node The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen. got7fsn_ti lymphocyte homing pr 2011-03-29T04:29:27Z biological_process owl:Class
GO:0042397 biolink:NamedThing phosphagen catabolic process The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction. got7fsn_ti phosphagen breakdown|phosphagen catabolism|phosphagen degradation biological_process owl:Class
GO:0102256 biolink:NamedThing neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity Catalysis of the reaction: neoagarohexaose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agaropentaose. got7fsn_ti MetaCyc:RXN-12429|EC:3.2.1.159 molecular_function owl:Class
GO:0036511 biolink:NamedThing trimming of first mannose on A branch The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. got7fsn_ti glycoprotein mannose trimming on A branch|conversion of M9 to M8A|conversion of (Man)9(GlcNAc)2 to (Man)8A(GlcNAc)2 Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. bf 2015-06-11T14:14:03Z biological_process owl:Class
GO:0120320 biolink:NamedThing lateral pseudopodium retraction The myosin-based contraction and retraction of a lateral pseudopodium. got7fsn_ti lateral pseudopodium suppression krc 2021-06-23T21:50:09Z biological_process owl:Class
GO:0031270 biolink:NamedThing pseudopodium retraction The myosin-based contraction and retraction of a pseudopodium. got7fsn_ti biological_process owl:Class
GO:0009643 biolink:NamedThing photosynthetic acclimation A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light. got7fsn_ti photoacclimation|light acclimatization biological_process owl:Class
GO:0044197 biolink:NamedThing Rel homology domain binding Binding to a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT. got7fsn_ti RHD binding jl 2009-10-20T03:57:48Z molecular_function owl:Class
GO:0120036 biolink:NamedThing plasma membrane bounded cell projection organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon. got7fsn_ti https://github.com/geneontology/go-ontology/issues/13298 krc 2017-04-26T16:07:02Z biological_process owl:Class
GO:0002396 biolink:NamedThing MHC protein complex assembly The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex. got7fsn_ti biological_process owl:Class
GO:0006021 biolink:NamedThing inositol biosynthetic process The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. got7fsn_ti vitamin Bh biosynthesis|inositol formation|myo-inositol biosynthesis|inositol biosynthesis|inositol synthesis|vitamin Bh biosynthetic process|inositol anabolism|myo-inositol biosynthetic process biological_process owl:Class
GO:0090648 biolink:NamedThing response to environmental enrichment Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment. got7fsn_ti response to the introduction of novel objects tb 2015-07-01T10:20:37Z biological_process owl:Class
GO:0071093 biolink:NamedThing alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex A protein complex that consists of an alpha5-beta1 integrin complex bound to fibronectin and tissue transglutaminase. got7fsn_ti ITGA5-ITGB1-FN1-TGM2 complex mah 2009-11-06T04:47:22Z cellular_component owl:Class
GO:0071188 biolink:NamedThing protocadherin-alpha-v7-protocadherin-gamma-a1 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdha7-Pcdhga1 complex mah 2009-11-23T04:23:25Z cellular_component owl:Class
GO:2001107 biolink:NamedThing negative regulation of Rho guanyl-nucleotide exchange factor activity Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. got7fsn_ti negative regulation of Rho guanine nucleotide exchange factor|negative regulation of RhoGEF yaf 2011-09-23T10:13:12Z biological_process owl:Class
GO:1905098 biolink:NamedThing negative regulation of guanyl-nucleotide exchange factor activity Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity. got7fsn_ti downregulation of guanyl-nucleotide release factor activity|downregulation of guanyl-nucleotide exchange factor activity|down regulation of guanyl-nucleotide exchange factor activity|downregulation of guanyl-nucleotide releasing factor|inhibition of guanyl-nucleotide releasing factor|down regulation of GEF|negative regulation of guanyl-nucleotide releasing factor|inhibition of GDS|down-regulation of GNRP|down regulation of guanyl-nucleotide releasing factor|inhibition of GEF|downregulation of GDP-dissociation stimulator activity|inhibition of GDP-dissociation stimulator activity|downregulation of GEF|negative regulation of GDS|down regulation of GNRP|down regulation of GDP-dissociation stimulator activity|inhibition of guanyl-nucleotide release factor activity|negative regulation of GEF|down regulation of GDS|downregulation of GDS|down-regulation of GDS|negative regulation of guanyl-nucleotide release factor activity|negative regulation of GDP-dissociation stimulator activity|down-regulation of GDP-dissociation stimulator activity|downregulation of GNRP|negative regulation of GNRP|inhibition of GNRP|inhibition of guanyl-nucleotide exchange factor activity|down-regulation of guanyl-nucleotide exchange factor activity|down-regulation of guanyl-nucleotide releasing factor|down-regulation of guanyl-nucleotide release factor activity|down regulation of guanyl-nucleotide release factor activity|down-regulation of GEF https://github.com/geneontology/go-ontology/issues/18750 sl 2016-03-31T16:09:45Z biological_process owl:Class
GO:0016498 biolink:NamedThing neuromedin K receptor activity Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity. got7fsn_ti neurokinin B receptor activity molecular_function owl:Class
GO:0060653 biolink:NamedThing epithelial cell differentiation involved in mammary gland cord morphogenesis The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland cord. Epithelial cells of the mammary cord give it its funnel-like shape and some are cornified. got7fsn_ti epithelial cell differentiation involved in mammary gland sprout morphogenesis dph 2009-05-29T09:17:16Z biological_process owl:Class
GO:0061435 biolink:NamedThing positive regulation of transcription from a mobile element promoter Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter. got7fsn_ti dph 2012-02-09T10:01:33Z biological_process owl:Class
GO:0061531 biolink:NamedThing primary amine secretion The regulated release of a primary amine by a cell. got7fsn_ti dph 2013-06-21T15:56:08Z biological_process owl:Class
GO:1903775 biolink:NamedThing regulation of DNA double-strand break processing Any process that modulates the frequency, rate or extent of DNA double-strand break processing. got7fsn_ti al 2015-01-06T17:08:15Z biological_process owl:Class
GO:0034003 biolink:NamedThing vetispiradiene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + vetispiradiene. got7fsn_ti trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming) activity|vetispiradiene-forming farnesyl pyrophosphate cyclase activity|pemnaspirodiene synthase activity|HVS|vetispiradiene cyclase activity KEGG_REACTION:R06523|EC:4.2.3.21|MetaCyc:RXN-4823|RHEA:10340 molecular_function owl:Class
GO:0019389 biolink:NamedThing glucuronoside metabolic process The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate. got7fsn_ti glucuronoside metabolism|glucuronide metabolism|glucuronide metabolic process biological_process owl:Class
GO:0007196 biolink:NamedThing adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway|metabotropic glutamate receptor, adenylate cyclase inhibiting pathway|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway biological_process owl:Class
GO:0102972 biolink:NamedThing gibberellin A12,2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A110-forming) Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 = gibberellin A110 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-947 molecular_function owl:Class
GO:0042198 biolink:NamedThing nylon metabolic process The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids. got7fsn_ti nylon metabolism biological_process owl:Class
GO:0047953 biolink:NamedThing glycerol 2-dehydrogenase (NADP+) activity Catalysis of the reaction: glycerol + NADP(+) = glycerone + H(+) + NADPH. got7fsn_ti glycerol:NADP+ 2-oxidoreductase (glycerone-forming)|dihydroxyacetone reductase activity|dihydroxyacetone (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|DHA oxidoreductase activity|dihydroxyacetone reductase (NADPH) MetaCyc:GLYCEROL-2-DEHYDROGENASE-NADP+-RXN|EC:1.1.1.156|RHEA:12753|KEGG_REACTION:R01039 molecular_function owl:Class
GO:0043760 biolink:NamedThing acetyldiaminopimelate aminotransferase activity Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate. got7fsn_ti N-acetyl-L,L-diaminopimelate aminotransferase activity|N-acetyl-diaminopimelate aminotransferase activity molecular_function owl:Class
GO:0031723 biolink:NamedThing CXCR4 chemokine receptor binding Binding to a CXCR4 chemokine receptor. got7fsn_ti CXCR4 chemokine receptor ligand|stromal cell-derived factor 1 receptor binding molecular_function owl:Class
GO:0001155 biolink:NamedThing TFIIIA-class transcription factor binding Binding to an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters. got7fsn_ti krc 2011-01-27T04:57:49Z molecular_function owl:Class
GO:0046028 biolink:NamedThing electron transporter, transferring electrons from cytochrome b6/f complex of photosystem II activity Enables the directed movement of electrons from the cytochrome b6/f complex of photosystem II. got7fsn_ti plastocyanin molecular_function owl:Class
GO:0006868 biolink:NamedThing glutamine transport The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-glutamine transport GO:0015815 biological_process owl:Class
GO:0033729 biolink:NamedThing anthocyanidin reductase activity Catalysis of the reaction: a flavan-3-ol + 2 NAD(P)+ = an anthocyanidin + 2 NAD(P)H + H+. got7fsn_ti MtANR|flavan-3-ol:NAD(P)+ oxidoreductase activity|ANR|AtANR MetaCyc:1.3.1.77-RXN|EC:1.3.1.77 molecular_function owl:Class
GO:0048930 biolink:NamedThing glial cell migration in posterior lateral line nerve The movement of a glial cell along the axons in the posterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0007395 biolink:NamedThing dorsal closure, spreading of leading edge cells Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa. got7fsn_ti biological_process owl:Class
GO:0031499 biolink:NamedThing TRAMP complex A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control. got7fsn_ti Trf4 poly(A) polymerase complex|TRAMP4 complex|TRAMP5 complex|Trf4p-Air2p-Mtr4p polyadenylation complex|Trf4 complex Wikipedia:TRAMP_complex cellular_component owl:Class
GO:0034288 biolink:NamedThing detection of disaccharide stimulus The series of events in which a stimulus from a disaccharide is received and converted into a molecular signal. got7fsn_ti perception of disaccharide stimulus biological_process owl:Class
GO:0050554 biolink:NamedThing abietadiene synthase activity Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate. got7fsn_ti abietadiene cyclase activity|copalyl-diphosphate diphosphate-lyase (cyclizing)|(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, (-)-abietadiene-forming) MetaCyc:4.2.3.18-RXN|EC:4.2.3.18|RHEA:13873|KEGG_REACTION:R06301 molecular_function owl:Class
GO:0000453 biolink:NamedThing enzyme-directed rRNA 2'-O-methylation The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA. got7fsn_ti biological_process owl:Class
GO:0103007 biolink:NamedThing indole-3-acetate carboxyl methyltransferase activity Catalysis of the reaction: indole-3-acetate + S-adenosyl-L-methionine <=> methyl (indol-3-yl)acetate + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.278|RHEA:36131|MetaCyc:RXN-9825 molecular_function owl:Class
GO:0034407 biolink:NamedThing cell wall (1->3)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells. got7fsn_ti cell wall beta-1,3 glucan metabolic process|cell wall 1,3-beta-glucan metabolism|cell wall 1,3-beta-D-glucan metabolic process|cell wall 1,3-beta-glucan metabolic process|cell wall beta-1,3 glucan metabolism biological_process owl:Class
GO:0006074 biolink:NamedThing (1->3)-beta-D-glucan metabolic process The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds. got7fsn_ti beta-1,3 glucan metabolic process|1,3-beta-glucan metabolic process|1,3-beta-D-glucan metabolism|1,3-beta-D-glucan metabolic process|beta-1,3 glucan metabolism biological_process owl:Class
GO:0050421 biolink:NamedThing nitrite reductase (NO-forming) activity Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+. got7fsn_ti methyl viologen-nitrite reductase activity|nitrite reductase (cytochrome; NO-forming) activity|cytochrome cd1 activity|NO-forming nitrite reductase (cytochrome) activity|cytochrome cd activity|Pseudomonas cytochrome oxidase activity|cd-cytochrome nitrite reductase activity|cytochrome c-551:O2, NO2+ oxidoreductase activity|NO-forming nitrite reductase activity|[nitrite reductase (cytochrome)]|cytochrome c-551:O(2), NO(2)(+) oxidoreductase activity|nitric-oxide:ferricytochrome-c oxidoreductase activity Note that EC:1.7.99.3 was merged into this term. GO:0016666 RHEA:15233|MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN|EC:1.7.2.1 molecular_function owl:Class
GO:0098676 biolink:NamedThing modulation of host virulence by virus Any process by which a virus modulates the ability of its host to infect and/or damage an organism for which it is a host. Typically this involves a phage modulating the virulence of a bacterium. Mechanisms include the expression of factors that modulate a bacterial adhesion to a host cell, spread through host tissues, production exotoxins or provide protection against host immune defenses. got7fsn_ti dos 2017-01-19T11:59:46Z VZ:3965 biological_process owl:Class
GO:0102796 biolink:NamedThing protocatechualdehyde:oxygen oxidoreductase activity Catalysis of the reaction: 3,4-dihydroxybenzaldehyde + O2 + H2O <=> H+ + 3,4-dihydroxybenzoate + hydrogen peroxide. got7fsn_ti MetaCyc:RXN-8091|EC:1.2.3.9 molecular_function owl:Class
GO:0033439 biolink:NamedThing ACA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACA codon. got7fsn_ti threonine tRNA Note that in the standard genetic code, ACA codes for threonine. molecular_function owl:Class
GO:0003921 biolink:NamedThing GMP synthase activity Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+). got7fsn_ti RHEA:18301|MetaCyc:GMP-SYN-NH3-RXN molecular_function owl:Class
GO:0044466 biolink:NamedThing glutaryl-CoA hydrolase activity Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate. got7fsn_ti glutaryl-CoA thioesterase activity jl 2012-01-17T04:16:43Z EC:3.1.2.3 molecular_function owl:Class
GO:0004424 biolink:NamedThing imidazoleglycerol-phosphate dehydratase activity Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O. got7fsn_ti IGP dehydratase activity|imidazoleglycerol phosphate dehydratase activity|D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity|D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming] EC:4.2.1.19|KEGG_REACTION:R03457|RHEA:11040|MetaCyc:IMIDPHOSDEHYD-RXN molecular_function owl:Class
GO:0047916 biolink:NamedThing GDP-6-deoxy-D-talose 4-dehydrogenase activity Catalysis of the reaction: GDP-6-deoxy-D-talose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H + H+. got7fsn_ti guanosine diphospho-6-deoxy-D-talose dehydrogenase activity|GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase activity EC:1.1.1.135|MetaCyc:GDP-6-DEOXY-D-TALOSE-4-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0051944 biolink:NamedThing positive regulation of catecholamine uptake involved in synaptic transmission Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of catecholamine neurotransmitters into a neuron or glial cell. got7fsn_ti positive regulation of catecholamine neurotransmitter reuptake|up-regulation of catecholamine uptake during transmission of nerve impulse|upregulation of catecholamine uptake during transmission of nerve impulse|positive regulation of catecholamine neurotransmitter uptake|activation of catecholamine uptake during transmission of nerve impulse|up regulation of catecholamine uptake during transmission of nerve impulse|stimulation of catecholamine uptake during transmission of nerve impulse|positive regulation of catecholamine uptake during transmission of nerve impulse biological_process owl:Class
GO:0047651 biolink:NamedThing alkylhalidase activity Catalysis of the reaction: bromochloromethane + H(2)O = bromide + chloride + formaldehyde + 2 H(+). got7fsn_ti alkyl-halide halidohydrolase activity|halogenase activity|haloalkane halidohydrolase activity MetaCyc:ALKYLHALIDASE-RXN|RHEA:13765|KEGG_REACTION:R03523 molecular_function owl:Class
GO:0002145 biolink:NamedThing 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+). got7fsn_ti HMP-PP diphosphatase|HMP-PP pyrophosphatase hjd 2009-06-10T11:21:35Z MetaCyc:RXN0-3543|RHEA:27914 molecular_function owl:Class
GO:0071000 biolink:NamedThing response to magnetism Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus. got7fsn_ti response to magnetic stimulus mah 2009-11-04T12:02:03Z biological_process owl:Class
GO:0070506 biolink:NamedThing high-density lipoprotein particle receptor activity Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis. got7fsn_ti high-density lipoprotein receptor activity|HDL receptor molecular_function owl:Class
GO:0047070 biolink:NamedThing 3-carboxyethylcatechol 2,3-dioxygenase activity Catalysis of the reaction: O2 + 3-(2,3-dihydroxyphenyl)propanoate = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate. got7fsn_ti 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing)|3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase activity|2,3-dihydroxy-beta-phenylpropionic dioxygenase activity|2,3-dihydroxy-beta-phenylpropionate oxygenase activity GO:0008669 MetaCyc:1.13.11.16-RXN|RHEA:23840|EC:1.13.11.16 molecular_function owl:Class
GO:0047956 biolink:NamedThing glycerol dehydrogenase [NADP+] activity Catalysis of the reaction: glycerol + NADP+ = D-glyceraldehyde + NADPH. got7fsn_ti glycerol:NADP+ oxidoreductase activity|glycerol dehydrogenase (NADP+) activity MetaCyc:GLYCEROL-DEHYDROGENASE-NADP+-RXN|RHEA:23592|EC:1.1.1.72 molecular_function owl:Class
GO:0051907 biolink:NamedThing S-(hydroxymethyl)glutathione synthase activity Catalysis of the reaction: S-(hydroxymethyl)glutathione = formaldehyde + glutathione. got7fsn_ti glutathione-dependent formaldehyde-activating enzyme activity|S-(hydroxymethyl)glutathione formaldehyde-lyase (glutathione-forming)|S-(hydroxymethyl)glutathione formaldehyde-lyase activity|Gfa UM-BBD_reactionID:r1145|MetaCyc:RXN-2961|EC:4.4.1.22|RHEA:22488|KEGG_REACTION:R06982 molecular_function owl:Class
GO:0035702 biolink:NamedThing monocyte homeostasis The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus. got7fsn_ti bf 2011-03-02T11:32:57Z biological_process owl:Class
GO:0050080 biolink:NamedThing malonyl-CoA decarboxylase activity Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. got7fsn_ti malonyl-CoA carboxy-lyase (acetyl-CoA-forming)|malonyl coenzyme A decarboxylase activity|malonyl-CoA carboxy-lyase activity MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN|EC:4.1.1.9|Reactome:R-HSA-977317|RHEA:18781 molecular_function owl:Class
GO:0002498 biolink:NamedThing proteolysis within endoplasmic reticulum associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation. got7fsn_ti proteolysis within ER associated with antigen processing and presentation|endoplasmic reticulum proteolysis associated with antigen processing and presentation|ER proteolysis associated with antigen processing and presentation biological_process owl:Class
GO:0048334 biolink:NamedThing regulation of mesodermal cell fate determination Any process that modulates the frequency, rate or extent of mesoderm cell fate determination. got7fsn_ti biological_process owl:Class
GO:0102337 biolink:NamedThing 3-oxo-cerotoyl-CoA synthase activity Catalysis of the reaction: tetracosanoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxohexacosanoyl-CoA + carbon dioxide + coenzyme A. got7fsn_ti MetaCyc:RXN-13296|RHEA:36515 molecular_function owl:Class
GO:0035540 biolink:NamedThing positive regulation of SNARE complex disassembly Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. got7fsn_ti bf 2010-05-10T01:42:21Z biological_process owl:Class
GO:0090483 biolink:NamedThing phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine. got7fsn_ti cardiolipin synthase tb 2012-10-03T14:20:05Z molecular_function owl:Class
GO:0019141 biolink:NamedThing 2-dehydropantolactone reductase (B-specific) activity Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+. got7fsn_ti 2-ketopantoyl lactone reductase activity|(R)-pantolactone:NADP+ oxidoreductase (B-specific)|2-oxopantoyl lactone reductase|2-dehydropantoyl-lactone reductase (B-specific) activity|ketopantoyl lactone reductase activity EC:1.1.1.214|MetaCyc:DEHYDROPANTLACRED-RXN molecular_function owl:Class
GO:0016728 biolink:NamedThing oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. got7fsn_ti oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor EC:1.17.4.- molecular_function owl:Class
GO:0036099 biolink:NamedThing female germ-line stem cell population maintenance The process by which an organism or tissue maintains a population of female germ-line stem cells. got7fsn_ti bf 2012-01-26T01:58:10Z biological_process owl:Class
GO:0008496 biolink:NamedThing mannan endo-1,6-alpha-mannosidase activity Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. got7fsn_ti exo-1,6-beta-mannanase activity|endo-alpha-D-mannosidase activity|1,6-alpha-D-mannan mannanohydrolase activity|endo-alpha-1->6-D-mannanase activity|endo-1,6-beta-mannanase activity|1,6-beta-D-mannan mannanohydrolase activity|mannan endo-1,6-beta-mannosidase activity MetaCyc:3.2.1.101-RXN|Reactome:R-HSA-6799581|EC:3.2.1.101 molecular_function owl:Class
GO:0047865 biolink:NamedThing dimethylglycine dehydrogenase activity Catalysis of the reaction: N,N-dimethylglycine + electron-transfer flavoprotein + H2O = sarcosine + formaldehyde + reduced electron-transfer flavoprotein. got7fsn_ti N,N-dimethylglycine oxidase activity|N,N-dimethylglycine:acceptor oxidoreductase (demethylating)|N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating) Note that this was EC:1.5.99.2. Reactome:R-HSA-6797653|EC:1.5.8.4|MetaCyc:DIMETHYLGLYCINE-DEHYDROGENASE-RXN|RHEA:52856|KEGG_REACTION:R01565 molecular_function owl:Class
GO:0010215 biolink:NamedThing cellulose microfibril organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall. got7fsn_ti cellulose microfibril organisation biological_process owl:Class
GO:0070551 biolink:NamedThing endoribonuclease activity, cleaving siRNA-paired mRNA Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an siRNA, yielding 5'-phosphomonoesters. got7fsn_ti argonaute endoribonuclease activity molecular_function owl:Class
GO:0046485 biolink:NamedThing ether lipid metabolic process The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. got7fsn_ti plasmalogen metabolic process|ether lipid metabolism Wikipedia:Ether_lipid biological_process owl:Class
GO:0103111 biolink:NamedThing D-glucosamine PTS permease activity Catalysis of the reaction: a [PTS enzyme I]-Npi-phospho-L-histidine + D-glucosamine <=> D-glucosamine 6-phosphate + a [PTS enzyme I]-L-histidine. got7fsn_ti MetaCyc:TRANS-RXN-167A|EC:2.7.1.69|RHEA:37359 molecular_function owl:Class
GO:0060486 biolink:NamedThing club cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles. got7fsn_ti Clara cell differentiation biological_process owl:Class
GO:0004478 biolink:NamedThing methionine adenosyltransferase activity Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. got7fsn_ti S-adenosylmethionine synthase activity|adenosylmethionine synthetase activity|S-adenosyl-L-methionine synthetase activity|S-adenosylmethionine synthetase activity|methionine S-adenosyltransferase activity|ATP:L-methionine S-adenosyltransferase activity|ATP-methionine adenosyltransferase activity|methionine-activating enzyme|AdoMet synthetase activity RHEA:21080|Reactome:R-HSA-5603087|Reactome:R-HSA-174391|EC:2.5.1.6|Reactome:R-HSA-5603114|MetaCyc:S-ADENMETSYN-RXN molecular_function owl:Class
GO:0051735 biolink:NamedThing GTP-dependent polynucleotide kinase activity Catalysis of the reaction: GTP + 5'-dephosphopolynucleotide = GDP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. got7fsn_ti GTP:5'-dephosphopolynucleotide 5'-phosphotransferase activity|GTP-dependent polynucleotide 5'-hydroxyl-kinase activity molecular_function owl:Class
GO:0009057 biolink:NamedThing macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. got7fsn_ti macromolecule degradation|macromolecule catabolism|biopolymer catabolic process|multicellular organismal macromolecule catabolic process|macromolecule breakdown GO:0044266|GO:0043285 biological_process owl:Class
GO:0051633 biolink:NamedThing positive regulation of acetylcholine uptake Any process that activates or increases the frequency, rate or extent of the directed movement of acetylcholine into a cell. got7fsn_ti up-regulation of acetylcholine uptake|positive regulation of acetylcholine import|activation of acetylcholine uptake|up regulation of acetylcholine uptake|stimulation of acetylcholine uptake|upregulation of acetylcholine uptake biological_process owl:Class
GO:0004819 biolink:NamedThing glutamine-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). got7fsn_ti GlnRS|glutaminyl-transfer ribonucleate synthetase activity|glutaminyl ribonucleic acid|glutaminyl-transfer RNA synthetase activity|L-glutamine:tRNAGln ligase (AMP-forming)|glutaminyl-tRNA synthetase activity|glutamine translase activity|glutamine-tRNA synthetase activity MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN|Reactome:R-HSA-379982|Reactome:R-HSA-380241|EC:6.1.1.18|RHEA:20121 molecular_function owl:Class
GO:0102355 biolink:NamedThing 2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity Catalysis of the reaction: 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + H2O <=> 3-maleylpyruvate + H+. got7fsn_ti EC:3.1.1.91|RHEA:33967|MetaCyc:RXN-13371 molecular_function owl:Class
GO:0008261 biolink:NamedThing allatostatin receptor activity Combining with allatostatin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0019178 biolink:NamedThing NADP phosphatase activity Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate. got7fsn_ti MetaCyc:NADPPHOSPHAT-RXN molecular_function owl:Class
GO:0032053 biolink:NamedThing ciliary basal body organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum). got7fsn_ti microtubule basal body organisation|microtubule basal body organization|microtubule basal body organization and biogenesis biological_process owl:Class
GO:0034956 biolink:NamedThing diphenyl ether 1,2-dioxygenase activity Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+. got7fsn_ti UM-BBD_reactionID:r1453|EC:1.13.11.- molecular_function owl:Class
GO:0102822 biolink:NamedThing quercetin 3'-O-methyltransferase activity Catalysis of the reaction: quercetin-7-olate + S-adenosyl-L-methionine = H+ + isorhamnetin + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:55332|EC:2.1.1.42|MetaCyc:RXN-8262 molecular_function owl:Class
GO:0048007 biolink:NamedThing antigen processing and presentation, exogenous lipid antigen via MHC class Ib The process in which an antigen-presenting cell expresses lipid antigen of exogenous origin in association with an MHC class Ib protein complex on its cell surface. Class Ib here refers to non-classical class I molecules, such as those of the CD1 family. got7fsn_ti exogenous lipid antigen processing and presentation via MHC class Ib|antigen presentation, exogenous peptide antigen biological_process owl:Class
GO:0031259 biolink:NamedThing uropod membrane The portion of the plasma membrane surrounding a uropod. got7fsn_ti uropodium membrane cellular_component owl:Class
GO:0019280 biolink:NamedThing L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine. got7fsn_ti L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine|L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine|L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine|methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine MetaCyc:HSERMETANA-PWY biological_process owl:Class
GO:0019279 biolink:NamedThing L-methionine biosynthetic process from L-homoserine via cystathionine The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine. got7fsn_ti L-methionine synthesis from L-homoserine via cystathionine|L-methionine formation from L-homoserine via cystathionine|methionine biosynthetic process from L-homoserine via cystathionine|L-methionine anabolism from L-homoserine via cystathionine MetaCyc:HOMOSER-METSYN-PWY biological_process owl:Class
GO:0051679 biolink:NamedThing 6-alpha-maltosylglucose metabolic process The chemical reactions and pathways involving 6-alpha-maltosylglucose, also known as isopanose. got7fsn_ti isopanose metabolic process|6-alpha-maltosylglucose metabolism|isopanose metabolism biological_process owl:Class
GO:0098977 biolink:NamedThing inhibitory chemical synaptic transmission Synaptic transmission that results in an inhibitory postsynaptic potential. got7fsn_ti biological_process owl:Class
GO:0003058 biolink:NamedThing hormonal regulation of the force of heart contraction The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. got7fsn_ti hormonal cardiac inotropy|hormonal regulation of the force of heart muscle contraction biological_process owl:Class
GO:0035990 biolink:NamedThing tendon cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance. got7fsn_ti muscle attachment cell differentiation|tenocyte differentiation bf 2011-08-26T04:16:06Z biological_process owl:Class
GO:0106291 biolink:NamedThing superoxide-generating NADH oxidase activity. Catalysis of the reaction: NADH + 2 O2 = H(+) + NAD(+) + 2 superoxide. got7fsn_ti hjd 2020-08-19T15:56:43Z RHEA:63184 molecular_function owl:Class
GO:0047510 biolink:NamedThing (S)-2-methylmalate dehydratase activity Catalysis of the reaction: S-citramalate = H(2)O + mesaconate. got7fsn_ti mesaconate mesaconase activity|mesaconate hydratase activity|mesaconase activity|L-citramalate hydrolase activity|(S)-2-methylmalate hydro-lyase activity|citramalate dehydratase activity|(+)-citramalic hydro-lyase activity|(+)-citramalate hydro-lyase activity|(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming) EC:4.2.1.34|KEGG_REACTION:R03693|RHEA:13529|MetaCyc:S-2-METHYLMALATE-DEHYDRATASE-RXN molecular_function owl:Class
GO:0050812 biolink:NamedThing regulation of acyl-CoA biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA. got7fsn_ti regulation of acyl-CoA formation|regulation of acyl-CoA synthesis|regulation of acyl-CoA anabolism|regulation of acyl-CoA biosynthesis biological_process owl:Class
GO:0102251 biolink:NamedThing all-trans-beta-apo-10'-carotenal cleavage oxygenase activity Catalysis of the reaction: 10'-apo-beta-carotenal + O2 <=> 13-apo-beta-carotenone + 4-methylocta-2,4,6-trienedial. got7fsn_ti MetaCyc:RXN-12393|EC:1.13.11.70|RHEA:26401 molecular_function owl:Class
GO:0047892 biolink:NamedThing flavone apiosyltransferase activity Catalysis of the reaction: UDP-apiose + 7-O-beta-D-glucosyl-5,7,4'-trihydroxyflavone = UDP + 7-O-(beta-D-apiofuranosyl-1,2-beta-D-glucosyl)-5,7,4'-trihydroxyflavone. got7fsn_ti uridine diphosphoapiose-flavone apiosyltransferase activity|UDP-apiose:7-O-(beta-D-glucosyl)-flavone apiosyltransferase activity|UDP-apiose:5,4'-dihydroxyflavone 7-O-beta-D-glucoside 2''-O-beta-D-apiofuranosyltransferase activity MetaCyc:FLAVONE-APIOSYLTRANSFERASE-RXN|RHEA:19153|EC:2.4.2.25 molecular_function owl:Class
GO:0033251 biolink:NamedThing cephalosporinase activity Catalysis of the reaction: a cephalosporin + H2O = a substituted beta-amino acid derivative of the cephalosporin. got7fsn_ti MetaCyc:BETA-LACTAMASE-RXN molecular_function owl:Class
GO:0033652 biolink:NamedThing host cell chloroplast A chlorophyll-containing plastid as found within host cells with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti cellular_component owl:Class
GO:0047216 biolink:NamedThing inositol 3-alpha-galactosyltransferase activity Catalysis of the reaction: myo-inositol + UDP-galactose = O-alpha-D-galactosyl-(1,3)-1D-myo-inositol + UDP. got7fsn_ti UDP-D-galactose:inositol galactosyltransferase activity|galactinol synthase activity|UDPgalactose:myo-inositol 1-alpha-D-galactosyltransferase activity|uridine diphosphogalactose-inositol galactosyltransferase activity|UDP-galactose:myo-inositol 1-alpha-D-galactosyltransferase activity|inositol 1-alpha-galactosyltransferase activity|UDP-galactose:myo-inositol 3-alpha-D-galactosyltransferase activity MetaCyc:2.4.1.123-RXN|RHEA:12464|EC:2.4.1.123 molecular_function owl:Class
GO:0102116 biolink:NamedThing laurate hydroxylase activity Catalysis of the reaction: dodecanoate + NADPH + O2 + H+ <=> 11-hydroxylaurate + NADP + H2O. got7fsn_ti MetaCyc:RXN-11340 molecular_function owl:Class
GO:0102646 biolink:NamedThing 14betaH-scalarane-17alpha-19-diol synthase activity Catalysis of the reaction: 14betaH-scalarane-17alpha-19-diol <=> all-trans-geranylfarnesol + H2O. got7fsn_ti MetaCyc:RXN-15759 molecular_function owl:Class
GO:0150059 biolink:NamedThing amylin receptor 1 signaling pathway A series of molecular signals initiated by an extracellular amylin, or another ligand, combining with an amylin receptor 1 (AMY1), a G protein-coupled receptor complex, on the surface of the target cell. Other ligands that have been shown to initiate the AMY1 signaling pathway include the calcitonin related peptide (CGRP) and adrenomedullin (AM/ADM). got7fsn_ti AMY1 signaling pathway bc 2018-06-21T10:58:02Z biological_process owl:Class
GO:0022832 biolink:NamedThing voltage-gated channel activity Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti molecular_function owl:Class
GO:0035000 biolink:NamedThing oligosaccharyltransferase III complex An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes. got7fsn_ti OSTCIII cellular_component owl:Class
GO:0043636 biolink:NamedThing bisphenol A catabolic process The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins. got7fsn_ti bisphenol-A catabolic process|bisphenol-A catabolism biological_process owl:Class
GO:0047735 biolink:NamedThing cellobiose dehydrogenase (acceptor) activity Catalysis of the reaction: cellobiose + acceptor = cellobiono-1,5-lactone + reduced acceptor. got7fsn_ti cellobiose:oxygen 1-oxidoreductase activity|cellobiose oxidase activity|phanerochaete chrysosporium cellobiose oxidoreductase activity|cellobiose:(acceptor) 1-oxidoreductase activity|CDH activity|CBOR activity|cellobiose:acceptor 1-oxidoreductase activity|cellobiose dehydrogenase (quinone) activity|cellobiose-quinone oxidoreductase activity|cellobiose dehydrogenase activity|cellobiose oxidoreductase activity GO:0047737 RHEA:23484|EC:1.1.99.18|MetaCyc:CELLOBIOSE-DEHYDROGENASE-ACCEPTOR-RXN molecular_function owl:Class
GO:0090473 biolink:NamedThing lys-arg specific dibasic protein processing Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein. got7fsn_ti tb 2012-10-01T10:42:30Z biological_process owl:Class
GO:0050129 biolink:NamedThing N-formylglutamate deformylase activity Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate. got7fsn_ti beta-citryl-L-glutamate amidase activity|beta-citryl-L-glutamate amidohydrolase activity|beta-citryl-L-glutamate-hydrolyzing enzyme|N-formyl-L-glutamate amidohydrolase activity|beta-citryl-L-glutamate hydrolase activity|formylglutamate deformylase activity|N-formylglutamate hydrolase activity|beta-citrylglutamate amidase activity EC:3.5.1.68|KEGG_REACTION:R00525|MetaCyc:N-FORMYLGLUTAMATE-DEFORMYLASE-RXN|RHEA:12476 molecular_function owl:Class
GO:0004028 biolink:NamedThing 3-chloroallyl aldehyde dehydrogenase activity Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. got7fsn_ti UM-BBD_enzymeID:e0432|Reactome:R-HSA-71260 molecular_function owl:Class
GO:0008117 biolink:NamedThing sphinganine-1-phosphate aldolase activity Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. got7fsn_ti sphinganine-1-phosphate palmitaldehyde-lyase activity|sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)|sphingosine-1-phosphate aldolase activity|dihydrosphingosine 1-phosphate aldolase activity|sphinganine-1-phosphate alkanal-lyase activity|sphingosine-1-phosphate lyase activity|sphinganine-1-phosphate lyase activity GO:0016001 EC:4.1.2.27|MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN|Reactome:R-HSA-428681|RHEA:18593|Reactome:R-HSA-428676 molecular_function owl:Class
GO:0052926 biolink:NamedThing dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. got7fsn_ti dolichylphosphomannose-dependent ALG9 mannosyltransferase activity MetaCyc:RXN-5467|RHEA:29531|EC:2.4.1.259|KEGG_REACTION:R06259 molecular_function owl:Class
GO:0018246 biolink:NamedThing protein-coenzyme A linkage The formation of a linkage between a protein amino acid and coenzyme A. got7fsn_ti biological_process owl:Class
GO:0047028 biolink:NamedThing 6-pyruvoyltetrahydropterin 2'-reductase activity Catalysis of the reaction: NADP+ + 6-lactoyl-5,6,7,8-tetrahydropterin = NADPH + H+ + 6-pyruvoyltetrahydropterin. got7fsn_ti 6-lactoyl-5,6,7,8-tetrahydropterin:NADP+ 2'-oxidoreductase activity|pyruvoyl-tetrahydropterin reductase activity|6-pyruvoyl tetrahydropterin (2'-oxo)reductase activity|6-pyruvoyltetrahydropterin reductase activity|6-pyruvoyl-tetrahydropterin 2'-reductase activity|6PPH4(2'-oxo) reductase activity RHEA:11772|MetaCyc:1.1.1.220-RXN|EC:1.1.1.220 molecular_function owl:Class
GO:0035476 biolink:NamedThing angioblast cell migration The orderly movement of angioblasts, cells involved in blood vessel morphogenesis. got7fsn_ti bf 2010-04-23T10:06:32Z biological_process owl:Class
GO:1990970 biolink:NamedThing trans-activation response element binding Binding to a trans-activation response (TAR) element, a hairpin RNA structure located at the 5' end of all HIV-1 transcripts, and which is required for trans-activation of a viral promoter. got7fsn_ti TAR binding bf 2016-06-21T12:23:00Z molecular_function owl:Class
GO:0070883 biolink:NamedThing pre-miRNA binding Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. got7fsn_ti precursor microRNA binding|pre-microRNA binding mah 2009-08-24T04:36:24Z molecular_function owl:Class
GO:0090578 biolink:NamedThing RNA polymerase V transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V. got7fsn_ti RNA polymerase V transcription factor complex tb 2014-05-09T14:04:37Z cellular_component owl:Class
GO:0052679 biolink:NamedThing terpentetriene synthase activity Catalysis of the reaction: terpentedienyl diphosphate = diphosphate + terpentetriene. got7fsn_ti terpentedienyl-diphosphate diphosphate-lyase (terpentetriene-forming) activity RHEA:25617|MetaCyc:RXN-9455|EC:4.2.3.36 molecular_function owl:Class
GO:0036304 biolink:NamedThing umbilical cord morphogenesis The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta. got7fsn_ti bf 2012-08-08T10:12:11Z biological_process owl:Class
GO:0075004 biolink:NamedThing adhesion of symbiont spore to host The attachment of a spore of the symbiont to its host via adhesion molecules, general stickiness etc. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti adhesion of symbiont spore to host during symbiotic interaction Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0016202 biolink:NamedThing regulation of striated muscle tissue development Any process that modulates the frequency, rate or extent of striated muscle development. got7fsn_ti biological_process owl:Class
GO:0061922 biolink:NamedThing histone propionyltransferase activity Catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone. got7fsn_ti dph 2017-08-02T13:38:50Z molecular_function owl:Class
GO:0061920 biolink:NamedThing protein propionyltransferase activity Catalysis of the reaction: propionyl-CoA + lysine in peptide = CoA + N-propionyl-lysine-peptide. got7fsn_ti dph 2017-08-02T13:35:22Z molecular_function owl:Class
GO:0015386 biolink:NamedThing potassium:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). got7fsn_ti potassium:hydrogen antiporter activity RHEA:29467 molecular_function owl:Class
GO:0071139 biolink:NamedThing resolution of recombination intermediates The cleavage and rejoining of intermediates, such as Holliday junctions, formed during DNA recombination to produce two intact molecules in which genetic material has been exchanged. got7fsn_ti mah 2009-11-16T12:02:21Z biological_process owl:Class
GO:0047125 biolink:NamedThing delta1-piperideine-2-carboxylate reductase activity Catalysis of the reaction: NADP+ + L-pipecolate = NADPH + delta1-piperideine-2-carboxylate. got7fsn_ti 1,2-didehydropipecolate reductase activity|D1-piperideine-2-carboxylate reductase activity|L-pipecolate:NADP+ 2-oxidoreductase activity|delta 1-piperideine-2-carboxylate reductase activity|P2C reductase activity|1,2-didehydropipecolic reductase activity RHEA:12524|MetaCyc:RXN-8166|EC:1.5.1.21 molecular_function owl:Class
GO:0097054 biolink:NamedThing L-glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid. got7fsn_ti L-glutamate synthesis|L-glutamate anabolism|L-glutamate formation|L-glutamate biosynthesis pr 2011-05-24T04:30:38Z biological_process owl:Class
GO:0071848 biolink:NamedThing positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling Any TNFSF11-mediated signaling process that increases the rate, frequency, or extent of the ERK1 and ERK2 cascade. got7fsn_ti positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalling|positive regulation of ERK1 and ERK2 cascade via RANKL-mediated signaling mah 2010-09-10T02:25:31Z biological_process owl:Class
GO:0070374 biolink:NamedThing positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. got7fsn_ti activation of ERK1 and ERK2 cascade|positive regulation of ERK1 cascade|positive regulation of ERK2 cascade|up-regulation of ERK1 and ERK2 cascade|positive regulation of MAPK1 cascade|positive regulation of ERK1 and ERK2 signalling pathway|positive regulation of ERK cascade|positive regulation of ERK1/2 cascade|positive regulation of MAPK3 cascade|stimulation of ERK1 and ERK2 cascade|upregulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 signaling pathway|up regulation of ERK1 and ERK2 cascade biological_process owl:Class
GO:0097005 biolink:NamedThing adipokinetic hormone receptor binding Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis. got7fsn_ti AKH receptor binding pr 2011-03-14T12:58:19Z molecular_function owl:Class
GO:0047567 biolink:NamedThing 3-methyleneoxindole reductase activity Catalysis of the reaction: 3-methyloxindole + NADP(+) = 3-methyleneoxindole + H(+) + NADPH. got7fsn_ti 3-methyloxindole:NADP+ oxidoreductase activity|3-methyl-1,3-dihydroindol-2-one:NADP+ oxidoreductase activity MetaCyc:3-METHYLENEOXINDOLE-REDUCTASE-RXN|EC:1.3.1.17|KEGG_REACTION:R03930|RHEA:20257 molecular_function owl:Class
GO:0002210 biolink:NamedThing behavioral response to wounding A behavioral response resulting from wounding. got7fsn_ti behavioural response to wounding biological_process owl:Class
GO:0009422 biolink:NamedThing bacterial-type flagellum hook-filament junction The region of the bacterial-type flagellum where the hook and filament meet. got7fsn_ti flagellar hook-filament junction cellular_component owl:Class
GO:0034869 biolink:NamedThing 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH. got7fsn_ti UM-BBD_reactionID:r1307 molecular_function owl:Class
GO:0036005 biolink:NamedThing response to macrophage colony-stimulating factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. got7fsn_ti response to macrophage colony-stimulating factor|response to M-CSF|response to macrophage colony-stimulating factor stimulus bf 2011-09-20T04:22:03Z biological_process owl:Class
GO:0047129 biolink:NamedThing opine dehydrogenase activity Catalysis of the reaction: (2S)-2-[(R)-1-carboxyethylamino]pentanoate + H(2)O + NAD(+) = L-2-aminopentanoate + H(+) + NADH + pyruvate. got7fsn_ti (2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate:NAD+ oxidoreductase (L-aminopentanoate-forming)|(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate dehydrogenase (NAD, L-aminopentanoate-forming) MetaCyc:1.5.1.28-RXN|RHEA:21592|EC:1.5.1.28|KEGG_REACTION:R03732 molecular_function owl:Class
GO:0042615 biolink:NamedThing CD154 receptor binding Binding to CD154, a receptor found on the surface of some activated lymphocytes. got7fsn_ti CD40 receptor activity|CD40L binding molecular_function owl:Class
GO:0102576 biolink:NamedThing 3-oxo-palmitoyl-ACP hydrolase activity Catalysis of the reaction: H2O + a 3-oxo-palmitoyl-[acp] = 3-oxopalmitic acid + H+ + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-15282 molecular_function owl:Class
GO:0071906 biolink:NamedThing CRD domain binding Binding to a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins. got7fsn_ti context dependent regulatory domain binding mah 2010-09-21T04:08:53Z molecular_function owl:Class
GO:0004067 biolink:NamedThing asparaginase activity Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3. got7fsn_ti alpha-asparaginase activity|asparaginase II|crasnitin|leunase activity|elspar|L-asparaginase activity|L-asparagine amidohydrolase activity|colaspase activity Reactome:R-HSA-6797627|EC:3.5.1.1|RHEA:21016|MetaCyc:ASPARAGHYD-RXN molecular_function owl:Class
GO:0033790 biolink:NamedThing hydroxymethylfurfural reductase activity Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+. got7fsn_ti molecular_function owl:Class
GO:0071585 biolink:NamedThing detoxification of cadmium ion Any process that reduces or removes the toxicity of cadmium ion. These may include transport of cadmium away from sensitive areas and to compartments or complexes whose purpose is sequestration of cadmium ion. got7fsn_ti mah 2010-01-28T03:38:48Z biological_process owl:Class
GO:0044874 biolink:NamedThing lipoprotein localization to outer membrane A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane. got7fsn_ti jl 2014-11-25T16:30:30Z biological_process owl:Class
GO:0019149 biolink:NamedThing 3-chloro-D-alanine dehydrochlorinase activity Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3. got7fsn_ti 3-chloro-D-alanine chloride-lyase (deaminating)|beta-chloro-D-alanine dehydrochlorinase activity|3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming) RHEA:18873|MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN|EC:4.5.1.2 molecular_function owl:Class
GO:0001108 biolink:NamedThing bacterial-type RNA polymerase holo enzyme binding Binding to a component of the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase. got7fsn_ti basal bacterial-type RNA polymerase transcription machinery binding krc 2010-11-30T04:26:04Z molecular_function owl:Class
GO:0008691 biolink:NamedThing 3-hydroxybutyryl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+. got7fsn_ti (S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity|beta-hydroxybutyryl coenzyme A dehydrogenase activity|dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)|BHBD activity|L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity|L(+)-3-hydroxybutyryl-CoA dehydrogenase activity|beta-hydroxybutyryl-CoA dehydrogenase activity EC:1.1.1.157|MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN|RHEA:16197 molecular_function owl:Class
GO:0018985 biolink:NamedThing pronuclear envelope synthesis Synthesis and ordering of the envelope of pronuclei. got7fsn_ti biological_process owl:Class
GO:0047042 biolink:NamedThing androsterone dehydrogenase (B-specific) activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. got7fsn_ti 3-alpha-HSD activity|3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (B-specific)|3alpha-hydroxysteroid oxidoreductase activity|3alpha-HSD|3-alpha-hydroxysteroid dehydrogenase (B-specific) activity|3alpha-hydroxysteroid dehydrogenase (B-specific)|sterognost 3alpha|hydroxyprostaglandin dehydrogenase activity Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(B-specific)|EC:1.1.1.50|MetaCyc:1.1.1.50-RXN molecular_function owl:Class
GO:0018498 biolink:NamedThing 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate. got7fsn_ti UM-BBD_enzymeID:e0308|MetaCyc:PHENPRODIOLDEHYDROG-RXN|RHEA:25062 molecular_function owl:Class
GO:0061725 biolink:NamedThing cytosolic lipolysis The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases. got7fsn_ti dph 2015-07-08T13:42:15Z biological_process owl:Class
GO:0090251 biolink:NamedThing protein localization involved in establishment of planar polarity Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity. got7fsn_ti protein localisation involved in establishment of planar polarity tb 2010-01-22T11:31:32Z biological_process owl:Class
GO:0086092 biolink:NamedThing regulation of the force of heart contraction by cardiac conduction A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled. got7fsn_ti dph 2011-11-29T01:26:41Z biological_process owl:Class
GO:0055113 biolink:NamedThing epiboly involved in gastrulation with mouth forming second The expansion of one cell sheet over other cells involved in deuterostomic gastrulation. got7fsn_ti biological_process owl:Class
GO:0002574 biolink:NamedThing thrombocyte differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis. got7fsn_ti Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. biological_process owl:Class
GO:0034697 biolink:NamedThing response to prostaglandin I Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin I stimulus. got7fsn_ti response to prostaglandin I stimulus biological_process owl:Class
GO:0070399 biolink:NamedThing wall teichoic acid catabolic process The chemical reactions and pathways resulting in the breakdown of wall teichoic acid, which is a major component of the cell wall of Gram-positive bacteria and typically consists of a polymer of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and D-alanyl ester residues and which is covalently linked to peptidoglycan. got7fsn_ti wall teichoic acid catabolism|wall teichoic acid breakdown|wall teichoic acid degradation biological_process owl:Class
GO:0047281 biolink:NamedThing dioxotetrahydropyrimidine phosphoribosyltransferase activity Catalysis of the reaction: pyrophosphate + a 2,4-dioxotetrahydropyrimidine D-ribonucleotide = PRPP + a 2,4-dioxotetrahydropyrimidine. got7fsn_ti dioxotetrahydropyrimidine ribonucleotide pyrophosphorylase activity|dioxotetrahydropyrimidine-ribonucleotide pyrophosphorylase activity|dioxotetrahydropyrimidine-ribonucleotide diphosphorylase activity|dioxotetrahydropyrimidine phosphoribosyl transferase activity|2,4-dioxotetrahydropyrimidine-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity RHEA:10232|EC:2.4.2.20|MetaCyc:2.4.2.20-RXN molecular_function owl:Class
GO:1990157 biolink:NamedThing DnaA-DnaB-DnaC complex A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation. got7fsn_ti bhm 2013-08-02T11:42:27Z cellular_component owl:Class
GO:0120326 biolink:NamedThing appressorium-mediated entry into host Penetration by a symbiont into a host organism via an appressorium. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti appressorium-mediated host invasion|appressorium-mediated penetration into host|appressorium-mediated invasion into host|appressorium-mediated host penetration https://github.com/geneontology/go-ontology/issues/21505 krc 2021-08-04T00:48:35Z biological_process owl:Class
GO:0050262 biolink:NamedThing ribosylnicotinamide kinase activity Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide. got7fsn_ti ribosylnicotinamide kinase (phosphorylating)|nicotinamide riboside kinase activity|ATP:N-ribosylnicotinamide 5'-phosphotransferase activity GO:0000816 Reactome:R-HSA-8869627|Reactome:R-HSA-8869633|KEGG_REACTION:R02324|EC:2.7.1.22|MetaCyc:RIBOSYLNICOTINAMIDE-KINASE-RXN|RHEA:14017 molecular_function owl:Class
GO:0002283 biolink:NamedThing neutrophil activation involved in immune response The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. got7fsn_ti neutrophil activation during immune response biological_process owl:Class
GO:0003360 biolink:NamedThing brainstem development The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord. got7fsn_ti dph 2009-12-03T10:47:20Z biological_process owl:Class
GO:0080141 biolink:NamedThing regulation of jasmonic acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of jasmonic acid. got7fsn_ti dhl 2009-05-19T04:28:39Z biological_process owl:Class
GO:0042304 biolink:NamedThing regulation of fatty acid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. got7fsn_ti regulation of fatty acid biosynthesis|regulation of fatty acid anabolism|regulation of fatty acid synthesis|regulation of fatty acid formation biological_process owl:Class
GO:0030790 biolink:NamedThing chlorophenol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole. got7fsn_ti halogenated phenol O-methyltransferase activity|trichlorophenol O-methyltransferase activity|S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity EC:2.1.1.136|MetaCyc:2.1.1.136-RXN|RHEA:18909 molecular_function owl:Class
GO:0034939 biolink:NamedThing 5-hydroxypyrrole-2-carboxylate tautomerase activity Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate. got7fsn_ti UM-BBD_reactionID:r0969 molecular_function owl:Class
GO:0010542 biolink:NamedThing nitrate efflux transmembrane transporter activity Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti molecular_function owl:Class
GO:0018781 biolink:NamedThing S-triazine hydrolase activity Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine. got7fsn_ti UM-BBD_enzymeID:e0091 molecular_function owl:Class
GO:0110068 biolink:NamedThing glucosylglycerate phosphorylase activity Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate. got7fsn_ti kmv 2017-11-21T21:50:10Z molecular_function owl:Class
GO:0062047 biolink:NamedThing pipecolic acid N-hydroxylase Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O. got7fsn_ti dph 2018-05-11T12:17:15Z molecular_function owl:Class
GO:0016078 biolink:NamedThing tRNA catabolic process The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. got7fsn_ti tRNA degradation|tRNA breakdown|tRNA catabolism biological_process owl:Class
GO:0033010 biolink:NamedThing paranodal junction A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. got7fsn_ti paranodal axoglial junction|paranodal septate junction|axoglial septate junction cellular_component owl:Class
GO:0035704 biolink:NamedThing helper T cell chemotaxis The directed movement of a helper T cell in response to an external stimulus. got7fsn_ti T-helper cell chemotaxis bf 2011-03-02T02:31:48Z biological_process owl:Class
GO:1990889 biolink:NamedThing H4K20me3 modified histone binding Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation. got7fsn_ti al 2015-10-30T15:43:09Z molecular_function owl:Class
GO:0102820 biolink:NamedThing norbixin methyltransferase activity Catalysis of the reaction: norbixin + S-adenosyl-L-methionine <=> bixin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-8238 molecular_function owl:Class
GO:0009381 biolink:NamedThing excinuclease ABC activity Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind. got7fsn_ti molecular_function owl:Class
GO:0034602 biolink:NamedThing oxoglutarate dehydrogenase (NAD+) activity Catalysis of the reaction: 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH. got7fsn_ti Reactome:R-HSA-71037|Reactome:R-HSA-71401|KEGG_REACTION:R08549|EC:1.2.1.105|MetaCyc:2OXOGLUTARATEDEH-RXN|RHEA:27786 molecular_function owl:Class
GO:1900803 biolink:NamedThing brevianamide F metabolic process The chemical reactions and pathways involving brevianamide F. got7fsn_ti L-tryptophyl-L-proline cyclic anhydride metabolism|tryptophan-proline diketopiperazine metabolic process|cyclo-L-tryptophanyl-L-proline metabolism|L-prolyl-L-tryptophan anhydride metabolic process|cyclo-(Trp-Pro) metabolism|cyclo-L-Trp-L-Pro metabolic process|cyclo-L-Trp-L-Pro metabolism|cyclo-L-tryptophanyl-L-proline metabolic process|brevianamide F metabolism|L-tryptophyl-L-proline cyclic anhydride metabolic process|tryptophan-proline diketopiperazine metabolism|L-prolyl-L-tryptophan anhydride metabolism di 2012-06-04T09:52:19Z biological_process owl:Class
GO:0036394 biolink:NamedThing amylase secretion The controlled release of amylase from a cell. got7fsn_ti amylase release bf 2013-07-01T13:03:19Z biological_process owl:Class
GO:0071042 biolink:NamedThing nuclear polyadenylation-dependent mRNA catabolic process The chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA. got7fsn_ti nuclear poly(A)-dependent mRNA catabolic process krc 2009-07-29T02:06:19Z biological_process owl:Class
GO:0042989 biolink:NamedThing sequestering of actin monomers The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers. got7fsn_ti actin monomer sequestering|actin monomer sequestration|sequestration of actin monomers|actin monomer storage|retention of actin monomers|actin monomer sequestering activity|storage of actin monomers|actin monomer retention biological_process owl:Class
GO:0102282 biolink:NamedThing 3-ketodihydrosphinganine (C18) reductase activity Catalysis of the reaction: NAD(1-) + a sphinganine <=> 3-dehydrosphinganinium(1+) + NADH + H+. got7fsn_ti MetaCyc:RXN-12641 molecular_function owl:Class
GO:0033475 biolink:NamedThing indoleacetic acid amide conjugate biosynthetic process The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an amino acid or polypeptide through an amide bond. got7fsn_ti indoleacetic acid amide conjugate biosynthesis|indoleacetic acid amide conjugate formation|indole acetic acid amide conjugate biosynthetic process|indole acetic acid amide conjugate biosynthesis|indoleacetic acid amide conjugate synthesis|IAA amide conjugate biosynthetic process|indoleacetic acid amide conjugate anabolism MetaCyc:PWY-1782 biological_process owl:Class
GO:0035310 biolink:NamedThing notum cell fate specification The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment. got7fsn_ti biological_process owl:Class
GO:0036345 biolink:NamedThing platelet maturation A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. got7fsn_ti bf 2012-09-11T15:23:11Z biological_process owl:Class
GO:0098680 biolink:NamedThing template-free RNA nucleotidyltransferase Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the addition of a terminal nucleotide to an RNA molecule in the absence of a nucleic acid template. got7fsn_ti dos 2017-01-31T15:51:56Z molecular_function owl:Class
GO:1905276 biolink:NamedThing regulation of epithelial tube formation Any process that modulates the frequency, rate or extent of epithelial tube formation. got7fsn_ti An example of this is MMRN2 in human (Q9H8L6) in PMID:25745997 (inferred from direct assay). bhm 2016-06-20T09:35:41Z biological_process owl:Class
GO:0097090 biolink:NamedThing presynaptic membrane organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. got7fsn_ti pre-synaptic membrane organization|presynaptic membrane organisation Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron. pr 2011-07-04T01:45:30Z biological_process owl:Class
GO:0008801 biolink:NamedThing beta-phosphoglucomutase activity Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate. got7fsn_ti beta-D-glucose 1,6-phosphomutase activity KEGG_REACTION:R02728|EC:5.4.2.6|MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN|RHEA:20113 molecular_function owl:Class
GO:0050619 biolink:NamedThing phytochromobilin:ferredoxin oxidoreductase activity Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin. got7fsn_ti PPhiB synthase activity|PFB synthase activity|HY2|phytochromobilin synthase activity|(3Z)-phytochromobilin:ferredoxin oxidoreductase activity|P-Phi-B synthase activity RHEA:16377|EC:1.3.7.4|MetaCyc:1.3.7.4-RXN molecular_function owl:Class
GO:0005316 biolink:NamedThing high-affinity inorganic phosphate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity inorganic phosphate:sodium symporter activity|sodium/phosphate cotransporter activity molecular_function owl:Class
GO:0005436 biolink:NamedThing sodium:phosphate symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). got7fsn_ti sodium/phosphate symporter activity|sodium-dependent phosphate transmembrane transporter activity https://github.com/geneontology/go-ontology/issues/18577 GO:0015321 Reactome:R-HSA-5625123|Reactome:R-HSA-5687585|Reactome:R-HSA-5651697|Reactome:R-HSA-2872498|Reactome:R-HSA-427645|Reactome:R-HSA-428609|Reactome:R-HSA-5651971|Reactome:R-HSA-427656|Reactome:R-HSA-427605|Reactome:R-HSA-5651685 molecular_function owl:Class
GO:0070194 biolink:NamedThing synaptonemal complex disassembly The controlled breakdown of a synaptonemal complex. got7fsn_ti biological_process owl:Class
GO:0047951 biolink:NamedThing glutathione thiolesterase activity Catalysis of the reaction: S-acylglutathione + H(2)O = a carboxylate + glutathione + H(+). got7fsn_ti S-acylglutathione hydrolase activity|glutathione thioesterase activity|citryl-glutathione thioesterhydrolase activity MetaCyc:GLUTATHIONE-THIOESTERASE-RXN|KEGG_REACTION:R00547|RHEA:22708|EC:3.1.2.7 molecular_function owl:Class
GO:0046129 biolink:NamedThing purine ribonucleoside biosynthetic process The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule. got7fsn_ti purine ribonucleoside synthesis|purine ribonucleoside formation|purine ribonucleoside biosynthesis|purine ribonucleoside anabolism biological_process owl:Class
GO:0003355 biolink:NamedThing cilium movement involved in otolith formation The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles. got7fsn_ti dph 2009-12-03T10:21:08Z biological_process owl:Class
GO:0014885 biolink:NamedThing detection of injury involved in regulation of muscle adaptation The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation. got7fsn_ti detection of injury involved in regulation of muscle plasticity biological_process owl:Class
GO:0014876 biolink:NamedThing response to injury involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation. got7fsn_ti response to injury involved in regulation of muscle plasticity biological_process owl:Class
GO:0033191 biolink:NamedThing macrophomate synthase activity Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate. got7fsn_ti molecular_function owl:Class
GO:0045208 biolink:NamedThing MAPK phosphatase export from nucleus The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm. got7fsn_ti MAPK phosphatase export from cell nucleus|MAPK phosphatase export out of nucleus|MAPK phosphatase transport from nucleus to cytoplasm|MAPK phosphatase-nucleus export biological_process owl:Class
GO:0046820 biolink:NamedThing 4-amino-4-deoxychorismate synthase activity Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. got7fsn_ti aminodeoxychorismate synthase activity|para-aminobenzoic acid synthase activity|PabB activity|para-aminobenzoic acid (PABA) synthase|p-aminobenzoate synthetase|ADC synthase activity|chorismate:L-glutamine amido-ligase activity Note that the name 'para-aminobenzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. RHEA:11672|EC:2.6.1.85|KEGG_REACTION:R01716|MetaCyc:PABASYN-RXN molecular_function owl:Class
GO:0046915 biolink:NamedThing transition metal ion transmembrane transporter activity Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. got7fsn_ti molecular_function owl:Class
GO:0004044 biolink:NamedThing amidophosphoribosyltransferase activity Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O. got7fsn_ti glutamine phosphoribosylpyrophosphate amidotransferase activity|phosphoribose pyrophosphate amidotransferase activity|glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity|5-phosphoribosyl-1-pyrophosphate amidotransferase activity|glutamine phosphoribosyldiphosphate amidotransferase activity|alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity|5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)|phosphoribosyl pyrophosphate amidotransferase activity|phosphoribosylpyrophosphate glutamyl amidotransferase activity|5'-phosphoribosylpyrophosphate amidotransferase activity|5-phosphororibosyl-1-pyrophosphate amidotransferase activity|phosphoribosyldiphosphate 5-amidotransferase activity|glutamine 5-phosphoribosylpyrophosphate amidotransferase activity RHEA:14905|EC:2.4.2.14|Reactome:R-HSA-73815|KEGG_REACTION:R01072|MetaCyc:PRPPAMIDOTRANS-RXN molecular_function owl:Class
GO:0106019 biolink:NamedThing phosphatidylinositol-4,5-bisphosphate phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. got7fsn_ti hjd 2017-05-10T14:22:12Z molecular_function owl:Class
GO:0003139 biolink:NamedThing secondary heart field specification The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract). got7fsn_ti anterior heart field specification|second heart field specification|SHF specification tb 2009-09-22T03:47:56Z biological_process owl:Class
GO:0106268 biolink:NamedThing 3,5-dichloro-THPH methyl transferase activity Catalysis of the reaction: (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + S-adenosyl-L-methionine = 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one + H+ + S-adenosyl-L-homocysteine. got7fsn_ti DIF-1 syntase hjd 2020-06-02T18:25:03Z RHEA:48396 molecular_function owl:Class
GO:0099047 biolink:NamedThing clearance of foreign intracellular RNA A defense process that protects an organism from invading foreign RNA. got7fsn_ti biological_process owl:Class
GO:0050357 biolink:NamedThing tropinesterase activity Catalysis of the reaction: atropine + H(2)O = H(+) + tropate + tropine. got7fsn_ti atropine esterase activity|atropine acylhydrolase activity|tropine esterase activity|atropinesterase activity|atropinase activity MetaCyc:TROPINESTERASE-RXN|RHEA:23304|KEGG_REACTION:R03563|EC:3.1.1.10 molecular_function owl:Class
GO:0006529 biolink:NamedThing asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. got7fsn_ti asparagine biosynthesis|asparagine formation|asparagine anabolism|asparagine synthesis biological_process owl:Class
GO:0005673 biolink:NamedThing transcription factor TFIIE complex A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH. got7fsn_ti cellular_component owl:Class
GO:0044677 biolink:NamedThing methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis. got7fsn_ti N5-methyltetrahydromethanopterin-coenzyme M methyltransferase complex|methyl-H4MPT|coenzyme M methyltransferase complex|5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex jl 2012-08-09T10:58:24Z cellular_component owl:Class
GO:0098983 biolink:NamedThing symmetric, GABA-ergic, inhibitory synapse A neuron to neuron synapse that lacks an electron dense postsynaptic specialization, uses GABA as a neurotransmitter and whose activity results in inhibitory postsynaptic potentials. got7fsn_ti cellular_component owl:Class
GO:0102778 biolink:NamedThing Delta9-tetrahydrocannabinolate synthase activity Catalysis of the reaction: cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide. got7fsn_ti EC:1.21.3.7|RHEA:34135|MetaCyc:RXN-7854 molecular_function owl:Class
GO:0001851 biolink:NamedThing complement component C3b binding Binding to a C3b product of the complement cascade. got7fsn_ti molecular_function owl:Class
GO:0044027 biolink:NamedThing hypermethylation of CpG island An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. got7fsn_ti DNA hypermethylation of CpG island biological_process owl:Class
GO:0071765 biolink:NamedThing nuclear inner membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner membrane. got7fsn_ti nuclear inner membrane organization and biogenesis|nuclear inner membrane organisation mah 2010-03-29T04:04:57Z biological_process owl:Class
GO:0097496 biolink:NamedThing blood vessel lumen ensheathment A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel. got7fsn_ti pr 2013-08-12T13:46:45Z biological_process owl:Class
GO:0050520 biolink:NamedThing phosphatidylcholine synthase activity Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+). got7fsn_ti PC synthase activity|CDP-diacylglycerol:choline O-phosphatidyltransferase activity|CDP-diglyceride-choline O-phosphatidyltransferase activity|CDPdiglyceride-choline O-phosphatidyltransferase activity KEGG_REACTION:R05794|EC:2.7.8.24|MetaCyc:2.7.8.24-RXN|RHEA:14597 molecular_function owl:Class
GO:0033975 biolink:NamedThing (R)-2-haloacid dehalogenase activity Catalysis of the reaction: (R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide. got7fsn_ti D-DEX|2-haloalkanoic acid dehalogenase activity|D-2-haloacid dehalogenase activity|2-haloalkanoid acid halidohydrolase activity|(R)-2-haloacid halidohydrolase activity MetaCyc:3.8.1.9-RXN|EC:3.8.1.9 molecular_function owl:Class
GO:0060662 biolink:NamedThing salivary gland cavitation The process in which the solid core of salivary epithelium gives rise to the hollow tube of the gland. got7fsn_ti salivary gland invagination dph 2009-06-01T08:22:55Z biological_process owl:Class
GO:0102028 biolink:NamedThing cystathionine gamma-synthase activity (acts on O-phosphohomoserine) Catalysis of the reaction: L-cysteine + O-phosphonato-L-homoserine = L-cystathionine + hydrogenphosphate. got7fsn_ti EC:2.5.1.48|MetaCyc:CYSPH-RXN molecular_function owl:Class
GO:0050438 biolink:NamedThing 2-ethylmalate synthase activity Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H(2)O = (R)-2-ethylmalate + CoA + H(+). got7fsn_ti (R)-2-ethylmalate 2-oxobutanoyl-lyase (CoA-acetylating) activity|propylmalate synthase activity|acetyl-CoA:2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)|propylmalic synthase activity|2-ethylmalate-3-hydroxybutanedioate synthase activity MetaCyc:2-ETHYLMALATE-SYNTHASE-RXN|KEGG_REACTION:R00998|RHEA:23040|EC:2.3.3.6 molecular_function owl:Class
GO:0044479 biolink:NamedThing envenomation resulting in modulation of mast cell degranulation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism. got7fsn_ti jl 2012-01-19T02:51:51Z biological_process owl:Class
GO:0009235 biolink:NamedThing cobalamin metabolic process The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. got7fsn_ti vitamin B12 metabolism|cobalamin metabolism|vitamin B12 reduction|vitamin B12 metabolic process biological_process owl:Class
GO:0050264 biolink:NamedThing rifamycin-B oxidase activity Catalysis of the reaction: 2 H(+) + O(2) + rifamycin B = H(2)O(2) + rifamycin O. got7fsn_ti rifamycin B oxidase activity|rifamycin-B-oxidase activity|rifamycin-B:oxygen oxidoreductase activity KEGG_REACTION:R03736|MetaCyc:RIFAMYCIN-B-OXIDASE-RXN|RHEA:11292|EC:1.10.3.6 molecular_function owl:Class
GO:0070921 biolink:NamedThing regulation of production of siRNA involved in gene silencing by small RNA Any process that modulates the frequency, rate or extent of the production of siRNA, the cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of gene silencing by small RNA. got7fsn_ti regulation of production of siRNA involved in chromatin silencing by small RNA|regulation of chromatin silencing by small RNA, production of siRNA https://github.com/geneontology/go-ontology/issues/22058 mah 2009-09-11T03:42:51Z biological_process owl:Class
GO:0035682 biolink:NamedThing toll-like receptor 21 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 21. got7fsn_ti toll-like receptor 21 signalling pathway|TLR21 signaling pathway bf 2011-02-21T02:39:39Z biological_process owl:Class
GO:0018844 biolink:NamedThing 2-hydroxytetrahydrofuran isomerase activity Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde. got7fsn_ti EC:5.3.99.-|UM-BBD_reactionID:r0019 molecular_function owl:Class
GO:0090728 biolink:NamedThing negative regulation of brood size Any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time. got7fsn_ti tb 2016-12-19T15:07:32Z biological_process owl:Class
GO:0007479 biolink:NamedThing leg disc proximal/distal pattern formation The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg. got7fsn_ti biological_process owl:Class
GO:0102064 biolink:NamedThing gamma-curcumene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> gamma-curcumene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10599|RHEA:32031|EC:4.2.3.94 molecular_function owl:Class
GO:0043451 biolink:NamedThing alkene catabolic process The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. got7fsn_ti alkene breakdown|alkene catabolism|alkene degradation biological_process owl:Class
GO:0070554 biolink:NamedThing synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex A SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 3, and a complexin (or orthologs thereof). got7fsn_ti SNARE complex (Stx3, Snap25, Vamp2, Cplx1)|Stx3-Snap25-Vamp2-Cplx1 complex cellular_component owl:Class
GO:0102919 biolink:NamedThing 5,6-dimethylbenzimidazole synthase activity Catalysis of the reaction: FMNH2 + O2 <=> 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialuric acid. got7fsn_ti RHEA:27345|EC:1.13.11.79|MetaCyc:RXN-8771 molecular_function owl:Class
GO:0031444 biolink:NamedThing slow-twitch skeletal muscle fiber contraction A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue. got7fsn_ti slow-twitch skeletal muscle fibre contraction biological_process owl:Class
GO:0047228 biolink:NamedThing 1,2-diacylglycerol 3-glucosyltransferase activity Catalysis of the reaction: 1,2-diacylglycerol + UDP-D-glucose = 3-D-glucosyl-1,2-diacylglycerol + UDP. got7fsn_ti UDPglucose:diacylglycerol glucosyltransferase activity|UDPglucose:1,2-diacylglycerol 3-D-glucosyltransferase activity|UDP-glucose:1,2-diacylglycerol 3-D-glucosyltransferase activity|UDP-glucose:1,2-diacylglycerol glucosyltransferase activity|UDP-glucose-diacylglycerol glucosyltransferase activity|uridine diphosphoglucose-diacylglycerol glucosyltransferase activity EC:2.4.1.157|MetaCyc:2.4.1.157-RXN molecular_function owl:Class
GO:0008012 biolink:NamedThing structural constituent of adult chitin-based cuticle The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster. got7fsn_ti structural constituent of adult cuticle molecular_function owl:Class
GO:0047380 biolink:NamedThing ADP-dependent medium-chain-acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. Requires ADP. got7fsn_ti ADP-dependent-medium-chain-acyl-CoA hydrolase activity|ADP-dependent myristoyl-CoA thioesterase activity|ADP-dependent medium-chain acyl-CoA hydrolase activity|ADP-dependent medium-chain acyl coenzyme A hydrolase activity|ADP-dependent medium-chain acyl-thioester hydrolase activity|ADP-dependent medium-chain hydrolase activity MetaCyc:3.1.2.19-RXN|EC:3.1.2.19 molecular_function owl:Class
GO:0001019 biolink:NamedThing plastid promoter transcription regulatory region sequence-specific DNA binding Binding to a DNA region that controls transcription by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. got7fsn_ti plastid promoter regulatory region sequence-specific DNA binding krc 2010-08-19T09:46:27Z molecular_function owl:Class
GO:0039595 biolink:NamedThing induction by virus of catabolism of host mRNA The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA). got7fsn_ti virus-mediated mRNA decay|induction by virus of host mRNA catabolic process|promotion of host mRNA degradation|induction of host mRNA decay|viral induction of host mRNA decay bf 2012-07-04T03:14:04Z VZ:901 biological_process owl:Class
GO:0061014 biolink:NamedThing positive regulation of mRNA catabolic process Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. got7fsn_ti positive regulation of mRNA decay dph 2010-01-29T01:58:03Z biological_process owl:Class
GO:0072259 biolink:NamedThing metanephric interstitial fibroblast development The process whose specific outcome is the progression of a metanephric interstitial fibroblast over time, from its formation to the mature structure. got7fsn_ti metanephros interstitial cell development mah 2010-03-19T04:18:00Z biological_process owl:Class
GO:0097719 biolink:NamedThing neural tissue regeneration The regrowth of neural tissue following its loss or destruction. got7fsn_ti neuroregeneration pr 2016-08-25T13:14:27Z biological_process owl:Class
GO:0072492 biolink:NamedThing host cell mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the host cell mitochondrial envelope. got7fsn_ti mah 2010-12-15T11:44:02Z cellular_component owl:Class
GO:0070191 biolink:NamedThing methionine-R-sulfoxide reductase activity Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on free oxidized methionine with specificity for the R enantiomer; does not act on oxidized methionine in peptide linkage. Thioredoxin disulfide is the oxidized form of thioredoxin. got7fsn_ti molecular_function owl:Class
GO:0021972 biolink:NamedThing corticospinal neuron axon guidance through spinal cord The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues. got7fsn_ti corticospinal neuron axon pathfinding through spinal cord biological_process owl:Class
GO:0140290 biolink:NamedThing peptidyl-serine ADP-deribosylation The removal of ADP-ribose from ADP-ribosylserine. got7fsn_ti pg 2018-11-22T14:32:30Z biological_process owl:Class
GO:0051725 biolink:NamedThing protein de-ADP-ribosylation The process of removing one or more ADP-ribose residues from a protein. got7fsn_ti protein poly(ADP-ribose) catabolism|protein poly(ADP-ribose) degradation|protein poly(ADP-ribose) hydrolysis|poly(ADP-ribose) removal from protein|protein poly(ADP-ribose) catabolic process|protein amino acid de-ADP-ribosylation|removal of ADP-ribose from protein biological_process owl:Class
GO:0008379 biolink:NamedThing thioredoxin peroxidase activity Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O. got7fsn_ti TrxPx activity|thiol peroxidase activity|TPx activity GO:0009031 RHEA:63528|Reactome:R-HSA-3697882|Reactome:R-HSA-3341343|Reactome:R-HSA-3697894|Reactome:R-HSA-2161612|MetaCyc:RXN0-267|Reactome:R-HSA-3322995 molecular_function owl:Class
GO:0044861 biolink:NamedThing protein transport into plasma membrane raft The directed movement of a protein into a plasma membrane raft. got7fsn_ti jl 2014-07-23T16:26:29Z biological_process owl:Class
GO:0045272 biolink:NamedThing plasma membrane respiratory chain complex I A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species. got7fsn_ti NADH dehydrogenase (ubiquinone) complex|respiratory chain complex I cellular_component owl:Class
GO:0047143 biolink:NamedThing chlorate reductase activity Catalysis of the reaction: AH(2) + chlorate = A + chlorite + H(2)O + H(+). got7fsn_ti chlorate reductase C|chlorite:acceptor oxidoreductase activity EC:1.97.1.1|KEGG_REACTION:R03575|MetaCyc:1.97.1.1-RXN|UM-BBD_reactionID:r0981|RHEA:16349 molecular_function owl:Class
GO:0090408 biolink:NamedThing phloem nitrate loading The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink. got7fsn_ti tb 2011-06-01T10:06:21Z biological_process owl:Class
GO:0052897 biolink:NamedThing N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity Catalysis of the reaction: H(2)O + N(8)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2). got7fsn_ti N(8)-acetylspermidine oxidase (propane-1,3-diamine-forming) activity RHEA:25972|EC:1.5.3.15|KEGG_REACTION:R09075|MetaCyc:RXN-10463 molecular_function owl:Class
GO:0004571 biolink:NamedThing mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. got7fsn_ti Man9-mannosidase activity|mannosidase I|mannosidase 1A activity|exo-alpha-1,2-mannanase activity|1,2-alpha-mannosidase|glycoprotein processing mannosidase I|man9-mannosidase activity|1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity|mannose-9 processing alpha-mannosidase activity|ManI activity|mannosidase 1B activity Reactome:R-HSA-9036008|Reactome:R-HSA-901074|EC:3.2.1.113|Reactome:R-HSA-6782685|Reactome:R-HSA-9036012|MetaCyc:3.2.1.113-RXN|Reactome:R-HSA-901039|Reactome:R-HSA-901024|KEGG_REACTION:R06722|Reactome:R-HSA-9696807|Reactome:R-HSA-964825|KEGG_REACTION:R05982|Reactome:R-HSA-901036|Reactome:R-HSA-4793949|Reactome:R-HSA-9036011|Reactome:R-HSA-964737|Reactome:R-HSA-964830 molecular_function owl:Class
GO:0033110 biolink:NamedThing Cvt vesicle membrane Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway. got7fsn_ti cytoplasm to vacuole targeting vesicle membrane|cytoplasm-to-vacuole targeting vesicle membrane cellular_component owl:Class
GO:0042620 biolink:NamedThing poly(3-hydroxyalkanoate) metabolic process The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria. got7fsn_ti poly(3-hydroxyalkanoate) metabolism|PHA metabolic process|PHA metabolism biological_process owl:Class
GO:0022874 biolink:NamedThing protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti cellobiose PTS transporter activity molecular_function owl:Class
GO:0030047 biolink:NamedThing actin modification Covalent modification of an actin molecule. got7fsn_ti GO:0007013 biological_process owl:Class
GO:0050837 biolink:NamedThing peptide cross-linking via L-cysteinyl-L-selenocysteine The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P. got7fsn_ti RESID:AA0358 biological_process owl:Class
GO:0070502 biolink:NamedThing capsule poly-gamma-glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of poly-gamma-glutamate, a polymer of D- and/or L-glutamic acid residues linked by gamma-peptidyl bonds, that forms all or part of a bacterial capsule. got7fsn_ti capsule poly-gamma-glutamate biosynthesis|capsule poly-gamma-glutamate formation|capsule poly-gamma-glutamate synthesis|capsule poly-gamma-glutamate anabolism|capsular poly-gamma-glutamate biosynthetic process biological_process owl:Class
GO:0008937 biolink:NamedThing ferredoxin-NAD(P) reductase activity Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+. got7fsn_ti ferredoxin reductase activity molecular_function owl:Class
GO:0016731 biolink:NamedThing oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. got7fsn_ti EC:1.18.1.- molecular_function owl:Class
GO:0045312 biolink:NamedThing nor-spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. got7fsn_ti nor-spermidine synthesis|nor-spermidine formation|nor-spermidine biosynthesis|nor-spermidine anabolism biological_process owl:Class
GO:0021555 biolink:NamedThing midbrain-hindbrain boundary morphogenesis The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate. got7fsn_ti MHB morphogenesis|isthmus morphogenesis biological_process owl:Class
GO:0090590 biolink:NamedThing protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in). got7fsn_ti tb 2014-06-04T16:33:01Z molecular_function owl:Class
GO:0061412 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids. got7fsn_ti dph 2012-01-12T12:54:05Z biological_process owl:Class
GO:0015888 biolink:NamedThing thiamine transport The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. got7fsn_ti vitamin B1 transport|thiamin transport biological_process owl:Class
GO:0098512 biolink:NamedThing detection of humidity stimulus involved in sensory perception The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity. got7fsn_ti dos 2013-09-25T14:09:25Z biological_process owl:Class
GO:0016361 biolink:NamedThing activin receptor activity, type I Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. got7fsn_ti type I activin receptor activity molecular_function owl:Class
GO:0061700 biolink:NamedThing GATOR2 complex A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. got7fsn_ti SEACAT complex The Rag GTPase complex corresponds to Gtr1-Gtr2 GTPase complex ; GO:1990131. dph 2015-05-07T11:13:27Z cellular_component owl:Class
GO:0043276 biolink:NamedThing anoikis Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix. got7fsn_ti detachment induced cell death|suspension induced apoptosis Wikipedia:Anoikis biological_process owl:Class
GO:0052005 biolink:NamedThing suppression by symbiont of host ethylene-mediated defense response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the ethylene-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti downregulation by symbiont of host ethylene-mediated defense response|negative regulation by organism of ethylene-mediated defense response of other organism involved in symbiotic interaction|suppression by organism of host ethylene-mediated defense response|negative regulation by symbiont of defense-related host ethylene-mediated signal transduction pathway|negative regulation by symbiont of host ethylene-mediated defense response|down regulation by symbiont of host ethylene-mediated defense response|negative regulation by organism of defense-related ethylene-mediated signal transduction pathway in other organism involved in symbiotic interaction|down-regulation by symbiont of host ethylene-mediated defense response|inhibition by symbiont of host ethylene-mediated defense response GO:0052268|GO:0052070|GO:0052254 biological_process owl:Class
GO:0097012 biolink:NamedThing response to granulocyte macrophage colony-stimulating factor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus. got7fsn_ti response to GM-CSF|response to granulocyte macrophage colony-stimulating factor stimulus pr 2011-03-22T01:12:15Z biological_process owl:Class
GO:0080023 biolink:NamedThing 3R-hydroxyacyl-CoA dehydratase activity Catalysis of the reaction: 3R-hydroxyacyl-CoA = 2E-enoyl-CoA + H2O. got7fsn_ti Reactome:R-HSA-5676637 molecular_function owl:Class
GO:0043874 biolink:NamedThing acireductone synthase activity Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. got7fsn_ti 5-(methylthio)-2,3-dioxopentyl-phosphate phosphohydrolase (isomerizing)|E-1|E-1 enolase-phosphatase This function is involved in the process of methionine salvage. EC:3.1.3.77|MetaCyc:3.1.3.77-RXN|RHEA:21700|Reactome:R-HSA-1237129 molecular_function owl:Class
GO:0044192 biolink:NamedThing host cell mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae. got7fsn_ti jl 2009-10-15T04:17:29Z cellular_component owl:Class
GO:1901271 biolink:NamedThing lipooligosaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipooligosaccharide. got7fsn_ti lipooligosaccharide synthesis|lipooligosaccharide biosynthesis|lipooligosaccharide anabolism|lipooligosaccharide formation yaf 2012-08-17T14:31:55Z biological_process owl:Class
GO:0050364 biolink:NamedThing tryptophan dimethylallyltransferase activity Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan. got7fsn_ti DMAT synthetase activity|dimethylallylpyrophosphate:L-tryptophan dimethylallyltransferase activity|dimethylallylpyrophosphate:tryptophan dimethylallyl transferase activity|dimethylallyltryptophan synthetase activity|dimethylallyl-diphosphate:L-tryptophan dimethylallyltransferase activity|4-(gamma,gamma-dimethylallyl)tryptophan synthase activity RHEA:14173|MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN|EC:2.5.1.34 molecular_function owl:Class
GO:0031702 biolink:NamedThing type 1 angiotensin receptor binding Binding to a type 1 angiotensin receptor. got7fsn_ti AT1 receptor binding|type 1 angiotensin receptor ligand molecular_function owl:Class
GO:0036205 biolink:NamedThing histone catabolic process The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells. got7fsn_ti histone protein catabolic process This term was created even though it describes a process relating to a group of gene products, because histones are highly conserved proteins that are essential components of cellular chromatin in eukaryotic cells. bf 2012-04-24T04:48:48Z biological_process owl:Class
GO:0032419 biolink:NamedThing extrinsic component of lysosome membrane The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to lysosomal membrane|extrinsic to lysosome membrane cellular_component owl:Class
GO:0061722 biolink:NamedThing sulphoglycolysis The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and pyruvate. got7fsn_ti sulfoglycolysis dph 2015-07-01T09:44:30Z biological_process owl:Class
GO:1903296 biolink:NamedThing positive regulation of glutamate secretion, neurotransmission Any process that activates or increases the frequency, rate or extent of glutamate secretion, where glutamate acts as a neurotransmitter. got7fsn_ti activation of glutamate secretion, neurotransmission|up regulation of glutamate secretion, neurotransmission|upregulation of glutamate secretion, neurotransmission|up-regulation of glutamate secretion, neurotransmission An example of this is Rab3gap1 in mouse (Q80UJ7) in PMID:16782817 inferred from mutant phenotype pad 2014-08-13T13:54:31Z biological_process owl:Class
GO:0050930 biolink:NamedThing induction of positive chemotaxis Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. got7fsn_ti biological_process owl:Class
GO:0050927 biolink:NamedThing positive regulation of positive chemotaxis Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. got7fsn_ti upregulation of positive chemotaxis|up-regulation of positive chemotaxis|stimulation of positive chemotaxis|up regulation of positive chemotaxis|activation of positive chemotaxis biological_process owl:Class
GO:0070586 biolink:NamedThing cell-cell adhesion involved in gastrulation The attachment of one cell to another cell affecting gastrulation. got7fsn_ti mah 2009-04-24T02:48:23Z biological_process owl:Class
GO:0035407 biolink:NamedThing histone H3-T11 phosphorylation The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone. got7fsn_ti bf 2010-03-24T10:12:01Z biological_process owl:Class
GO:0120134 biolink:NamedThing proximal portion of axoneme The portion of the axoneme that is close to the base of the cilium. got7fsn_ti proximal part of axoneme krc 2018-03-10T01:41:06Z cellular_component owl:Class
GO:0031782 biolink:NamedThing type 4 melanocortin receptor binding Binding to a type 4 melanocortin receptor. got7fsn_ti type 4 melanocortin receptor ligand molecular_function owl:Class
GO:0039641 biolink:NamedThing viral inner membrane The lipid bilayer of a virion contained inside the protein capsid. got7fsn_ti virion inner membrane bf 2012-09-07T13:29:48Z cellular_component owl:Class
GO:2001290 biolink:NamedThing hydroperoxide metabolic process The chemical reactions and pathways involving a hydroperoxide. got7fsn_ti hydroperoxide metabolism pr 2012-02-09T03:35:37Z biological_process owl:Class
GO:0033822 biolink:NamedThing glucosyl-DNA beta-glucosyltransferase activity Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a glucosylhydroxymethylcytosine residue in DNA. got7fsn_ti T6-beta-glucosyl transferase activity|T6-glucosyl-HMC-beta-glucosyl transferase activity|uridine diphosphoglucose-glucosyldeoxyribonucleate beta-glucosyltransferase activity|UDPglucose:D-glucosyl-DNA beta-D-glucosyltransferase activity|UDP-glucose:D-glucosyl-DNA beta-D-glucosyltransferase activity EC:2.4.1.28|MetaCyc:2.4.1.28-RXN molecular_function owl:Class
GO:0102113 biolink:NamedThing hypoxia-inducible factor-asparagine oxygenase activity Catalysis of the reaction: 2-oxoglutarate + O2 + a hypoxia inducible factor (HIF) alpha subunit = succinate + carbon dioxide + a (3S)-3-hydroxy-L-asparagine-HIF alpha subunit. got7fsn_ti MetaCyc:RXN-11321|RHEA:54268|EC:1.14.11.30 molecular_function owl:Class
GO:0009132 biolink:NamedThing nucleoside diphosphate metabolic process The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar. got7fsn_ti nucleoside diphosphate metabolism biological_process owl:Class
GO:0051425 biolink:NamedThing PTB domain binding Binding to a phosphotyrosine-binding (PTB) Binding to a phosphotyrosine-bindin domain. got7fsn_ti PID binding|phosphotyrosine-interacting domain binding molecular_function owl:Class
GO:0061027 biolink:NamedThing umbilical cord development The process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta. got7fsn_ti dph 2010-02-09T09:09:22Z biological_process owl:Class
GO:0008866 biolink:NamedThing fructuronate reductase activity Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH. got7fsn_ti mannonic dehydrogenase activity|D-mannonate:NAD+ 5-oxidoreductase activity|D-mannonate oxidoreductase activity|mannonate oxidoreductase activity|D-mannonate:NAD oxidoreductase activity|D-mannonate dehydrogenase activity MetaCyc:MANNONOXIDOREDUCT-RXN|EC:1.1.1.57|KEGG_REACTION:R02454|RHEA:15729 molecular_function owl:Class
GO:0047207 biolink:NamedThing 1,2-beta-fructan 1F-fructosyltransferase activity Catalysis of the reaction: [(1->2)-beta-D-fructosyl](n) + [(1->2)-beta-D-fructosyl](m) = [(1->2)-beta-D-fructosyl](n+1) + [(1->2)-beta-D-fructosyl](m-1). got7fsn_ti 2,1-beta-D-fructan:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity|1,2-beta-fructan 1(F)-fructosyltransferase activity|2,1-fructan:2,1-fructan 1-fructosyltransferase activity|1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity|FFT activity|1,2-beta-D-fructan 1F-fructosyltransferase activity|1,2-beta-D-fructan 1(F)-fructosyltransferase activity|fructan:fructan fructosyl transferase activity|1,2-beta-D-fructan:1,2-beta-D-fructan 1(F)-beta-D-fructosyltransferase activity EC:2.4.1.100|MetaCyc:2.4.1.100-RXN molecular_function owl:Class
GO:0098568 biolink:NamedThing external side of mycolate outer membrane The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface. got7fsn_ti cellular_component owl:Class
GO:0098927 biolink:NamedThing vesicle-mediated transport between endosomal compartments A cellular transport process in which transported substances are moved in membrane-bounded vesicles between endosomal compartments, e.g, between early endosome and sorting endosome. got7fsn_ti biological_process owl:Class
GO:0018720 biolink:NamedThing phenol kinase activity Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate. got7fsn_ti MetaCyc:PHENOLPHOS-RXN|UM-BBD_reactionID:r0155 molecular_function owl:Class
GO:0007537 biolink:NamedThing inactivation of recombination (HML) The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae. got7fsn_ti biological_process owl:Class
GO:0051955 biolink:NamedThing regulation of amino acid transport Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0071814 biolink:NamedThing protein-lipid complex binding Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. got7fsn_ti mah 2010-09-06T04:26:27Z molecular_function owl:Class
GO:0070628 biolink:NamedThing proteasome binding Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation. got7fsn_ti mah 2009-05-01T04:38:58Z molecular_function owl:Class
GO:0045451 biolink:NamedThing pole plasm oskar mRNA localization Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm. got7fsn_ti establishment and maintenance of oskar mRNA localization in pole plasm|establishment and maintenance of pole plasm oskar mRNA localization|pole plasm oskar mRNA localisation|oocyte pole plasm oskar mRNA localization biological_process owl:Class
GO:0019094 biolink:NamedThing pole plasm mRNA localization Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte pole plasm mRNA localization|pole granule RNA localization|pole plasm mRNA localisation|establishment and maintenance of mRNA localization in pole plasm|establishment and maintenance of pole plasm mRNA localization GO:0048120 biological_process owl:Class
GO:0031255 biolink:NamedThing lateral part of motile cell The area of a motile cell perpendicular to the direction of movement. got7fsn_ti cellular_component owl:Class
GO:0050573 biolink:NamedThing dTDP-4-dehydro-6-deoxyglucose reductase activity Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH. got7fsn_ti dTDP-4-keto-6-deoxyglucose reductase activity|dTDP-D-fucose:NADP+ oxidoreductase activity MetaCyc:1.1.1.266-RXN|RHEA:36583|KEGG_REACTION:R05687|EC:1.1.1.266 molecular_function owl:Class
GO:0052916 biolink:NamedThing 23S rRNA (guanine(1835)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:42744|MetaCyc:RXN-11635|KEGG_REACTION:R07234|EC:2.1.1.174 molecular_function owl:Class
GO:0097320 biolink:NamedThing plasma membrane tubulation A membrane tubulation process occurring in a plasma membrane. got7fsn_ti membrane tubulation|vesicle scission pr 2012-05-31T10:01:22Z biological_process owl:Class
GO:0004835 biolink:NamedThing tubulin-tyrosine ligase activity Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. got7fsn_ti alpha-tubulin:L-tyrosine ligase (ADP-forming)|tubulinyl-tyrosine ligase activity|TTL activity RHEA:17605|EC:6.3.2.25|MetaCyc:6.3.2.25-RXN|Reactome:R-HSA-8955706 molecular_function owl:Class
GO:0015019 biolink:NamedThing heparan-alpha-glucosaminide N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide. got7fsn_ti heparin-alpha-glucosaminide N-acetyltransferase activity|acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity|acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity Reactome:R-HSA-9036056|EC:2.3.1.78|Reactome:R-HSA-1678660|Reactome:R-HSA-2263492|Reactome:R-HSA-2090085|MetaCyc:2.3.1.78-RXN|RHEA:15125 molecular_function owl:Class
GO:0080056 biolink:NamedThing petal vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the petal of vascular plants. got7fsn_ti dhl 2009-04-13T02:25:01Z biological_process owl:Class
GO:1990742 biolink:NamedThing microvesicle An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm. got7fsn_ti shedding vesicle|extracellular microvesicle|ectosome pr 2015-05-13T13:44:52Z cellular_component owl:Class
GO:2000706 biolink:NamedThing negative regulation of dense core granule biogenesis Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule biogenesis. got7fsn_ti yaf 2011-05-26T10:29:27Z biological_process owl:Class
GO:0102407 biolink:NamedThing sn-2-glycerol-3-phosphate C22:0-DCA-CoA acyl transferase activity Catalysis of the reaction: C22:0-DCA-CoA + sn-glycerol 3-phosphate <=> coenzyme A + 2-C22:0-DCA-LPA. got7fsn_ti MetaCyc:RXN-13734 molecular_function owl:Class
GO:0019255 biolink:NamedThing glucose 1-phosphate metabolic process The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1. got7fsn_ti glucose 1-phosphate utilization|glucose 1-phosphate metabolism GO:0006008 MetaCyc:GLUCOSE1PMETAB-PWY biological_process owl:Class
GO:0003914 biolink:NamedThing DNA (6-4) photolyase activity Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA. got7fsn_ti MetaCyc:RXN-10771|EC:4.1.99.13 molecular_function owl:Class
GO:0046816 biolink:NamedThing virion transport vesicle A vesicle used to transport the partial or complete virion between cellular compartments. got7fsn_ti cellular_component owl:Class
GO:0097752 biolink:NamedThing regulation of DNA stability Any process that modulates the stability of DNA. got7fsn_ti pr 2017-01-24T11:23:01Z biological_process owl:Class
GO:0035365 biolink:NamedThing regulation of thymine transport Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti regulation of 5-methyluracil transport bf 2010-03-11T10:22:54Z biological_process owl:Class
GO:0062040 biolink:NamedThing fungal biofilm matrix An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses. got7fsn_ti dph 2018-05-04T12:54:39Z cellular_component owl:Class
GO:0086018 biolink:NamedThing SA node cell to atrial cardiac muscle cell signaling Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. got7fsn_ti SAN cardiomyocyte to atrial cardiomyocyte signalling|SA node cardiomyocyte to atrial cardiomyocyte signalling|sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling|SA node cardiac muscle cell to atrial cardiac muscle cell signalling|sinus node cardiomyocyte to atrial cardiomyocyte signalling tb 2011-11-10T09:15:01Z biological_process owl:Class
GO:0034655 biolink:NamedThing nucleobase-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids. got7fsn_ti nucleobase, nucleoside, nucleotide and nucleic acid catabolism|nucleobase, nucleoside, nucleotide and nucleic acid breakdown|nucleobase, nucleoside, nucleotide and nucleic acid catabolic process|nucleobase, nucleoside, nucleotide and nucleic acid degradation biological_process owl:Class
GO:0071703 biolink:NamedThing detection of organic substance The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal. got7fsn_ti mah 2010-03-08T03:18:44Z biological_process owl:Class
GO:0008880 biolink:NamedThing glucuronate isomerase activity Catalysis of the reaction: D-glucuronate = D-fructuronate. got7fsn_ti uronic acid isomerase activity|D-glucuronate ketol-isomerase activity|uronic isomerase activity|D-glucuronate isomerase activity|D-glucuronate aldose-ketose-isomerase activity|uronate isomerase activity RHEA:13049|MetaCyc:GLUCUROISOM-RXN|EC:5.3.1.12 molecular_function owl:Class
GO:0051835 biolink:NamedThing positive regulation of synapse structural plasticity Any process that activates, maintains or increases the frequency, rate or extent of synaptic structural plasticity. got7fsn_ti up-regulation of synapse structural plasticity|up regulation of synapse structural plasticity|stimulation of synapse structural plasticity|upregulation of synapse structural plasticity|activation of synapse structural plasticity biological_process owl:Class
GO:0001118 biolink:NamedThing transcription ternary complex disassembly The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components. got7fsn_ti transcription protein-DNA-RNA complex disassembly krc 2010-12-03T04:11:34Z biological_process owl:Class
GO:0045203 biolink:NamedThing integral component of cell outer membrane The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to external membrane|integral to cell outer membrane|integral to outer membrane cellular_component owl:Class
GO:0003100 biolink:NamedThing regulation of systemic arterial blood pressure by endothelin The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor. got7fsn_ti biological_process owl:Class
GO:0050363 biolink:NamedThing tryptophan dehydrogenase activity Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+. got7fsn_ti L-tryptophan dehydrogenase activity|L-Trp-dehydrogenase activity|TrpDH activity|NAD(P)+-L-tryptophan dehydrogenase activity|TDH|L-tryptophan:NAD(P)+ oxidoreductase (deaminating) EC:1.4.1.19|MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0102266 biolink:NamedThing tRNA-dihydrouridine20a synthase activity Catalysis of the reaction: a 5,6-dihydrouracil20a in tRNA + NAD(P) <=> H+ + a uracil20a in tRNA + NAD(P)H. got7fsn_ti EC:1.3.1.90|MetaCyc:RXN-12475 molecular_function owl:Class
GO:0040022 biolink:NamedThing feminization of hermaphroditic germ-line The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite. got7fsn_ti biological_process owl:Class
GO:0075508 biolink:NamedThing entry of viral genome into host nucleus via retainment of capsid in nuclear pore complex and release of genome into nucleoplasm Viral penetration into the host nucleus where a viral capsid enters the host nuclear pore complex (NPC) but remains attached to the pore on the nuclear side. The capsid then disassembles, releasing the viral genome into the nucleoplasm. got7fsn_ti entry of viral genome into host nucleus via attachment of capsid to nuclear pore complex and release of genome into nucleoplasm This mechanism is used by viruses such as Hepadnaviridae whose capsids enter the NPC but are too big to pass intact into the nucleus. jl 2011-07-26T04:56:10Z biological_process owl:Class
GO:0007615 biolink:NamedThing anesthesia-resistant memory The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis. got7fsn_ti biological_process owl:Class
GO:0080152 biolink:NamedThing regulation of reductive pentose-phosphate cycle Any process that modulates the frequency, rate or extent of reductive pentose-phosphate cycle. got7fsn_ti regulation of C3 photosynthesis|regulation of Calvin cycle dhl 2010-07-01T02:49:55Z biological_process owl:Class
GO:0007367 biolink:NamedThing segment polarity determination Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products. got7fsn_ti biological_process owl:Class
GO:0004079 biolink:NamedThing biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase). got7fsn_ti biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)|biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)|methylmalonyl coenzyme A holotranscarboxylase synthetase activity|biotin-methylmalonyl-CoA-carboxytransferase synthetase activity|biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity|biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity|biotin-methylmalonyl-CoA-carboxytransferase ligase activity|biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity|biotin-methylmalonyl-CoA-carboxyltransferase synthetase|biotin-methylmalonyl-CoA-carboxyltransferase ligase activity|biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity|biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity|biotin-transcarboxylase synthetase activity EC:6.3.4.9|RHEA:23668|MetaCyc:6.3.4.9-RXN molecular_function owl:Class
GO:0097322 biolink:NamedThing 7SK snRNA binding Binding to a 7SK small nuclear RNA (7SK snRNA). got7fsn_ti 7SK small nuclear RNA binding pr 2012-06-05T11:42:23Z molecular_function owl:Class
GO:0043263 biolink:NamedThing cellulosome An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose. got7fsn_ti scaffoldin complex GO:1990296 Wikipedia:Cellulosome cellular_component owl:Class
GO:0120153 biolink:NamedThing calcium-dependent carbohydrate binding Binding to a carbohydrate in the presence of calcium. got7fsn_ti krc 2018-04-27T16:42:21Z molecular_function owl:Class
GO:0030246 biolink:NamedThing carbohydrate binding Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. got7fsn_ti sugar binding|selectin GO:0005529 molecular_function owl:Class
GO:0047576 biolink:NamedThing 4-chlorobenzoate dehalogenase activity Catalysis of the reaction: 4-chlorobenzoate + H(2)O = 4-hydroxybenzoate + chloride + H(+). got7fsn_ti 4-chlorobenzoate chlorohydrolase activity|halobenzoate dehalogenase activity RHEA:23440|MetaCyc:4-CHLOROBENZOATE-DEHALOGENASE-RXN|KEGG_REACTION:R01307|EC:3.8.1.6 molecular_function owl:Class
GO:0150058 biolink:NamedThing amylin receptor complex 3 A G protein-coupled receptor complex that serves as a receptor for amylin polypeptide (AMY) and consists of a calcitonin receptor (CTR/CALCR) and a receptor activity-modifying protein (RAMP) 3. Amylin receptor complex 3 (AMY3) also serves as a receptor for the amyloid-beta complex. Ligand binding to AMY3 results in increased cytosolic calcium ion levels and in activation on multiple intracellular signalling pathways. got7fsn_ti AMY3 complex bc 2018-06-21T10:54:00Z cellular_component owl:Class
GO:0014871 biolink:NamedThing cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction. got7fsn_ti biological_process owl:Class
GO:0070390 biolink:NamedThing transcription export complex 2 A protein complex that couples SAGA-dependent gene expression to mRNA export at the inner side of the nuclear pore complex (NPC). The TREX-2 complex is tethered to the inner side of the NPC via the nucleoporins Nup1 and Nup60; in S. cerevisiae it contains Sac3p, Thp1p, Sem1, Sus1p and Cdc31p. got7fsn_ti TREX-2 complex|Sac3-Thp1-Sus1-Sem1-Cdc31 complex cellular_component owl:Class
GO:0102439 biolink:NamedThing 3',4',5'-trimethylmyricetin 7-O-methyltransferase activity Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 7,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-13916 molecular_function owl:Class
GO:0015090 biolink:NamedThing low-affinity ferric iron ion transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low affinity iron transporter activity|low affinity iron ion transmembrane transporter activity molecular_function owl:Class
GO:0102763 biolink:NamedThing phytyl-P kinase activity Catalysis of the reaction: phytyl phosphate(2-) + a nucleoside triphosphate <=> (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + a nucleoside diphosphate. got7fsn_ti RHEA:38099|MetaCyc:RXN-7763 molecular_function owl:Class
GO:0010086 biolink:NamedThing embryonic root morphogenesis The process in which the anatomical structures of the embryonic root are generated and organized. got7fsn_ti biological_process owl:Class
GO:0060365 biolink:NamedThing coronal suture morphogenesis The process in which the coronal suture is generated and organized. got7fsn_ti biological_process owl:Class
GO:0008839 biolink:NamedThing 4-hydroxy-tetrahydrodipicolinate reductase Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+. got7fsn_ti dihydrodipicolinate reductase activity|dihydrodipicolinic acid reductase activity|2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity EC:1.17.1.8|MetaCyc:DIHYDROPICRED-RXN molecular_function owl:Class
GO:0042610 biolink:NamedThing CD8 receptor binding Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. got7fsn_ti molecular_function owl:Class
GO:0061671 biolink:NamedThing Cbp3p-Cbp6 complex A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly. got7fsn_ti dph 2014-11-18T15:08:30Z cellular_component owl:Class
GO:0004828 biolink:NamedThing serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). got7fsn_ti seryl-transfer RNA synthetase activity|seryl-tRNA synthetase activity|serine translase activity|seryl-transfer ribonucleic acid synthetase activity|L-serine:tRNASer ligase (AMP-forming)|SerRS activity|seryl-transfer ribonucleate synthetase activity Reactome:R-HSA-379992|Reactome:R-HSA-380239|RHEA:12292|EC:6.1.1.11|MetaCyc:SERINE--TRNA-LIGASE-RXN molecular_function owl:Class
GO:0050281 biolink:NamedThing serine-glyoxylate transaminase activity Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine. got7fsn_ti SGAT activity|serine--glyoxylate aminotransferase activity|L-serine:glyoxylate aminotransferase activity MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN|RHEA:19125|EC:2.6.1.45 molecular_function owl:Class
GO:0004024 biolink:NamedThing alcohol dehydrogenase activity, zinc-dependent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. got7fsn_ti Reactome:R-HSA-71707 molecular_function owl:Class
GO:0008466 biolink:NamedThing glycogenin glucosyltransferase activity Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. got7fsn_ti glycogenin activity|alpha-1,4-glucan-protein synthase (UDP-forming) activity|UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity|priming glucosyltransferase activity|UDP-glucose:glycogenin glucosyltransferase activity|1,4alpha-glucan-protein synthase (UDP-forming) activity GO:0047210 Reactome:R-HSA-3814838|RHEA:23360|Reactome:R-HSA-3322014|MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN|Reactome:R-HSA-3322019|Reactome:R-HSA-3322025|EC:2.4.1.186|Reactome:R-HSA-3322003 molecular_function owl:Class
GO:0008860 biolink:NamedThing ferredoxin-NAD+ reductase activity Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+. got7fsn_ti ferredoxin-nicotinamide adenine dinucleotide reductase activity|ferredoxin:NAD+ oxidoreductase activity|NADH flavodoxin oxidoreductase activity|NADH-ferredoxinTOL reductase (component of toluene dioxygenase)|NADH-ferredoxin oxidoreductase activity|ferredoxin-NAD reductase activity|NAD-ferredoxin reductase activity|NADH-ferredoxin reductase activity|NADH2-ferredoxin oxidoreductase activity|reductase, reduced nicotinamide adenine dinucleotide-ferredoxin|NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)|ferredoxin-linked NAD reductase activity MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN|RHEA:16521|EC:1.18.1.3 molecular_function owl:Class
GO:0102954 biolink:NamedThing dalcochinase activity Catalysis of the reaction: dalcochinin-8'-O-beta-glucoside + H2O <=> dalcochinin + D-glucopyranose. got7fsn_ti MetaCyc:RXN-9162 molecular_function owl:Class
GO:0036106 biolink:NamedThing peroxisome membrane class-2 targeting sequence binding Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner. got7fsn_ti class 2 mPTS binding|PEX19-independent mPTS binding Currently identified mPTSs vary greatly in length, and cannot be distinguished by primary structure analysis, suggesting that the peroxisomal sorting information is not contained within a specific amino acid sequence. There do however appear to be two classes of mPTSs: class 1 mPTSs that are bound by PEX19 and imported in a PEX19-dependent manner, and class 2 mPTSs that are not bound by PEX19 and mediate protein import independently of PEX19. The two classes cannot be defined based on their amino acid sequence. bf 2012-01-27T02:02:22Z molecular_function owl:Class
GO:0008820 biolink:NamedThing cobinamide phosphate guanylyltransferase activity Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H(+) = adenosylcobinamide-GDP + diphosphate. got7fsn_ti CobU|adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase|GTP:cobinamide phosphate guanylyltransferase activity|GTP:adenosylcobinamide-phosphate guanylyltransferase activity|AdoCbi kinase/AdoCbi-phosphate guanylyltransferase|adenosylcobinamide-phosphate guanylyltransferase activity GO:0043753 RHEA:22712|KEGG_REACTION:R05222|EC:2.7.7.62|MetaCyc:COBINPGUANYLYLTRANS-RXN molecular_function owl:Class
GO:0047691 biolink:NamedThing aspulvinone dimethylallyltransferase activity Catalysis of the reaction: aspulvinone E + 2 dimethylallyl diphosphate = aspulvinone H + 2 diphosphate. got7fsn_ti dimethylallyl pyrophosphate:aspulvinone dimethylallyltransferase activity|dimethylallyl-diphosphate:aspulvinone-E dimethylallyltransferase activity EC:2.5.1.35|MetaCyc:ASPULVINONE-DIMETHYLALLYLTRANSFERASE-RXN|KEGG_REACTION:R03799|RHEA:13809 molecular_function owl:Class
GO:0047895 biolink:NamedThing formaldehyde dismutase activity Catalysis of the reaction: 2 formaldehyde + H2O = methanol + formate. got7fsn_ti aldehyde dismutase activity|cannizzanase activity|nicotinoprotein aldehyde dismutase|formaldehyde:formaldehyde oxidoreductase activity RHEA:19221|MetaCyc:FORMALDEHYDE-DISMUTASE-RXN|EC:1.2.98.1 molecular_function owl:Class
GO:0106235 biolink:NamedThing ceramide-1-phosphate phosphatase activity Catalysis of the reaction: ceramide-1-phosphate + H2O = ceramide+ phosphate. got7fsn_ti hjd 2019-11-21T20:40:39Z RHEA:50888 molecular_function owl:Class
GO:0042577 biolink:NamedThing lipid phosphatase activity Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. got7fsn_ti molecular_function owl:Class
GO:0048465 biolink:NamedThing corolla development The process whose specific outcome is the progression of the corolla over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0048335 biolink:NamedThing negative regulation of mesodermal cell fate determination Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate determination. got7fsn_ti down regulation of mesodermal cell fate determination|inhibition of mesodermal cell fate determination|down-regulation of mesodermal cell fate determination|downregulation of mesodermal cell fate determination biological_process owl:Class
GO:0043335 biolink:NamedThing protein unfolding The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state. got7fsn_ti biological_process owl:Class
GO:0050642 biolink:NamedThing 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA. got7fsn_ti 2-debenzoyl-7,13-diacetylbaccatin III-2-O-benzoyl transferase activity|benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity|2alpha-hydroxytaxane 2-O-benzoyltransferase activity|benzoyl-CoA:taxan-2alpha-ol O-benzoyltransferase activity|2a-hydroxytaxane 2-O-benzoyltransferase activity|benzoyl-CoA:taxane 2-alpha-O-benzoyltransferase activity RHEA:18741|EC:2.3.1.166|MetaCyc:2.3.1.166-RXN|KEGG_REACTION:R06310 molecular_function owl:Class
GO:1902108 biolink:NamedThing regulation of mitochondrial membrane permeability involved in apoptotic process Any regulation of mitochondrial membrane permeability that is involved in apoptotic process. got7fsn_ti regulation of mitochondrial membrane permeability involved in apoptotic program|regulation of mitochondrial membrane permeability involved in apoptotic programmed cell death|regulation of mitochondrial membrane permeability involved in type I programmed cell death|regulation of transport across mitochondrial membrane involved in apoptotic cell death|regulation of mitochondrial membrane permeability involved in programmed cell death by apoptosis|regulation of mitochondrial membrane permeability involved in signaling (initiator) caspase activity|regulation of transport across mitochondrial membrane involved in apoptotic programmed cell death|regulation of transport across mitochondrial membrane involved in type I programmed cell death|regulation of mitochondrial membrane permeability involved in apoptotic cell death|regulation of transport across mitochondrial membrane involved in signaling (initiator) caspase activity|regulation of transport across mitochondrial membrane involved in apoptotic process|regulation of transport across mitochondrial membrane involved in apoptotic program|regulation of mitochondrial membrane permeability involved in apoptosis|regulation of transport across mitochondrial membrane involved in apoptosis|regulation of transport across mitochondrial membrane involved in programmed cell death by apoptosis pr 2013-05-03T12:09:35Z biological_process owl:Class
GO:0004222 biolink:NamedThing metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. got7fsn_ti metalloendoproteinase activity|metalloendoprotease activity Reactome:R-HSA-8874187|MetaCyc:3.4.24.61-RXN|MetaCyc:3.4.24.21-RXN|Reactome:R-HSA-1251992|Reactome:R-HSA-1474210|Reactome:R-HSA-8940641|Reactome:R-HSA-381518|MetaCyc:3.4.24.35-RXN|EC:3.4.24.18|Reactome:R-HSA-264758|MetaCyc:3.4.24.17-RXN|Reactome:R-HSA-5250606|MetaCyc:3.4.24.24-RXN|EC:3.4.24.22|EC:3.4.24.11|Reactome:R-HSA-2533965|Reactome:R-HSA-8949668|MetaCyc:3.4.24.57-RXN|Reactome:R-HSA-8874194|MetaCyc:3.4.24.56-RXN|Reactome:R-HSA-2534240|Reactome:R-HSA-8876868|EC:3.4.24.61|Reactome:R-HSA-1299476|MetaCyc:3.4.24.69-RXN|Reactome:R-HSA-1564164|Reactome:R-HSA-1564112|Reactome:R-HSA-194800|Reactome:R-HSA-2179402|Reactome:R-HSA-3788075|MetaCyc:3.4.24.23-RXN|EC:3.4.24.72|MetaCyc:3.4.24.55-RXN|Reactome:R-HSA-2533950|Reactome:R-HSA-381537|MetaCyc:3.4.24.71-RXN|Reactome:R-HSA-1564179|Reactome:R-HSA-2485111|EC:3.4.24.37|Reactome:R-HSA-177946|Reactome:R-HSA-420818|Reactome:R-HSA-1564184|Reactome:R-HSA-4224014|Reactome:R-HSA-1474213|MetaCyc:3.4.24.18-RXN|Reactome:R-HSA-2514831|Reactome:R-HSA-8940561|EC:3.4.24.57|Reactome:R-HSA-9624272|Reactome:R-HSA-2473594|EC:3.4.24.14|Reactome:R-HSA-3827958|MetaCyc:3.4.24.37-RXN|EC:3.4.24.59|Reactome:R-HSA-2534248|Reactome:R-HSA-1168777|EC:3.4.24.-|Reactome:R-HSA-1564143|Reactome:R-HSA-3791295|Reactome:R-HSA-1564142|Reactome:R-HSA-2002428|Reactome:R-HSA-5694082|Reactome:R-HSA-8874195|Reactome:R-HSA-1592310|Reactome:R-HSA-181567|Reactome:R-HSA-3791149|Reactome:R-HSA-8949649|Reactome:R-HSA-2473596|Reactome:R-HSA-8940959|EC:3.4.24.23|Reactome:R-HSA-3791319|Reactome:R-HSA-5333671|EC:3.4.24.19|Reactome:R-HSA-1474196|Reactome:R-HSA-5362793|Reactome:R-HSA-3791155|Reactome:R-HSA-1299478|Reactome:R-HSA-2485148|MetaCyc:3.4.24.64-RXN|Reactome:R-HSA-8874192|Reactome:R-HSA-194809|MetaCyc:3.4.24.22-RXN|EC:3.4.24.56|EC:3.4.24.17|Reactome:R-HSA-5250978|EC:3.4.24.69|Reactome:R-HSA-8940554|Reactome:R-HSA-2514790|MetaCyc:3.4.24.59-RXN|Reactome:R-HSA-6784620|Reactome:R-HSA-5228578|MetaCyc:3.4.24.14-RXN|EC:3.4.24.35|Reactome:R-HSA-1454822|EC:3.4.24.70|Reactome:R-HSA-8942302|Reactome:R-HSA-2533970|Reactome:R-HSA-194796|Reactome:R-HSA-3828025|Reactome:R-HSA-2168046|Reactome:R-HSA-1655851|EC:3.4.24.64|Reactome:R-HSA-4086205|Reactome:R-HSA-2002440|Reactome:R-HSA-381435|Reactome:R-HSA-1454757|Reactome:R-HSA-3371385|Reactome:R-HSA-2473584|Reactome:R-HSA-8877620|MetaCyc:3.4.24.70-RXN|Reactome:R-HSA-2533874|Reactome:R-HSA-194793|Reactome:R-HSA-1564120|Reactome:R-HSA-5250962|Reactome:R-HSA-8874201|Reactome:R-HSA-8867344|Reactome:R-HSA-8949659|EC:3.4.24.55|Reactome:R-HSA-1564117|Reactome:R-HSA-194818|MetaCyc:3.4.24.19-RXN|EC:3.4.24.24|Reactome:R-HSA-2533944|MetaCyc:3.4.24.72-RXN|Reactome:R-HSA-2022141|Reactome:R-HSA-194808|Reactome:R-HSA-8943959|Reactome:R-HSA-2537499|EC:3.4.24.71|MetaCyc:3.4.24.11-RXN|Reactome:R-HSA-1564169|Reactome:R-HSA-1458433|EC:3.4.24.21|Reactome:R-HSA-2484882|Reactome:R-HSA-2168982|Reactome:R-HSA-5250892 molecular_function owl:Class
GO:0080065 biolink:NamedThing 4-alpha-methyl-delta7-sterol oxidation A lipid oxidation process proceeding through a series of three successive monooxygenations of the alpha methyl group on the C4 carbon (CH3 to CH2OH to CHO to COOH) and resulting in this overall reaction: 4-alpha-methyl-delta7-sterol + 3 NADPH + 3 H+ + 3 O2 = 4-alpha-carboxy,delta7-sterol + 3 NADP+ + 3 H2O. got7fsn_ti 4-alpha-methyl-delta7-sterol-4alpha-methyl oxidase activity dhl 2009-04-13T03:41:50Z biological_process owl:Class
GO:0097077 biolink:NamedThing copper ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+). got7fsn_ti pr 2011-06-17T09:57:11Z molecular_function owl:Class
GO:0015327 biolink:NamedThing cystine:glutamate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out). got7fsn_ti molecular_function owl:Class
GO:0034915 biolink:NamedThing 2-methylhexanoyl-CoA C-acetyltransferase activity Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA. got7fsn_ti EC:2.3.1.-|UM-BBD_reactionID:r0927 molecular_function owl:Class
GO:0005500 biolink:NamedThing juvenile hormone binding Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. got7fsn_ti molecular_function owl:Class
GO:0048643 biolink:NamedThing positive regulation of skeletal muscle tissue development Any process that activates, maintains or increases the rate of skeletal muscle tissue development. got7fsn_ti upregulation of skeletal muscle development|activation of skeletal muscle development|stimulation of skeletal muscle development|up regulation of skeletal muscle development|up-regulation of skeletal muscle development biological_process owl:Class
GO:0090400 biolink:NamedThing stress-induced premature senescence A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays. got7fsn_ti SIPS tb 2011-01-05T02:32:29Z biological_process owl:Class
GO:1903982 biolink:NamedThing negative regulation of microvillus length A process that decreases the length of a microvillus. got7fsn_ti down regulation of regulation of microvillus length|downregulation of regulation of microvillus length|down-regulation of regulation of microvillus length|inhibition of regulation of microvillus length als 2015-03-03T13:23:52Z biological_process owl:Class
GO:0031345 biolink:NamedThing negative regulation of cell projection organization Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. got7fsn_ti negative regulation of cell projection organization and biogenesis|inhibition of cell projection organization|down-regulation of cell projection organization|negative regulation of cell projection organisation|down regulation of cell projection organization|downregulation of cell projection organization biological_process owl:Class
GO:0030083 biolink:NamedThing PSI associated light-harvesting complex I, LHCIa subcomplex A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm. got7fsn_ti cellular_component owl:Class
GO:0009518 biolink:NamedThing PSI associated light-harvesting complex I Protein-pigment complex associated with photosystem I. got7fsn_ti LHCI cellular_component owl:Class
GO:0033208 biolink:NamedThing UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide. got7fsn_ti Sda beta 1,4GalNAc transferase|UDP-GalNAc:Neu5Ac-alpha-2-Gal-beta-1-R beta-1,4-N-acetylgalactosaminyltransferase activity molecular_function owl:Class
GO:0033398 biolink:NamedThing zeatin biosynthetic process The chemical reactions and pathways resulting in the formation of zeatin, 2-methyl-4-(9H-purin-6-ylamino)but-2-en-1-ol. got7fsn_ti zeatin synthesis|zeatin biosynthesis|zeatin formation|zeatin anabolism biological_process owl:Class
GO:0031619 biolink:NamedThing homologous chromosome orientation involved in meiotic metaphase I plate congression The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I. got7fsn_ti homologous chromosome orientation during meiosis I|homologous chromosome orientation during meiosis biological_process owl:Class
GO:0002173 biolink:NamedThing low-affinity IgM receptor activity Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti low affinity IgM receptor activity hjd 2010-05-06T05:04:24Z molecular_function owl:Class
GO:0051112 biolink:NamedThing peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine). got7fsn_ti RESID:AA0371 biological_process owl:Class
GO:0061547 biolink:NamedThing glycogen synthase activity, transferring glucose-1-phosphate Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate. got7fsn_ti dph 2013-07-02T09:59:18Z Reactome:R-HSA-3781024|Reactome:R-HSA-3780994 molecular_function owl:Class
GO:0047033 biolink:NamedThing 15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity Catalysis of the reaction: NADP(+) + prostaglandin I(2) = 15-dehydro-prostaglandin I(2) + H(+) + NADPH. got7fsn_ti PG I2 dehydrogenase activity|NADP+-dependent PGI2-specific 15-hydroxyprostaglandin dehydrogenase activity|prostacyclin dehydrogenase activity|(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity|NADP-linked 15-hydroxyprostaglandin (prostacyclin) dehydrogenase activity KEGG_REACTION:R03520|RHEA:21420|EC:1.1.1.231|MetaCyc:1.1.1.231-RXN molecular_function owl:Class
GO:0010450 biolink:NamedThing inflorescence meristem growth The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers. got7fsn_ti biological_process owl:Class
GO:0008504 biolink:NamedThing monoamine transmembrane transporter activity Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. got7fsn_ti GO:0015201 Reactome:R-HSA-5660706|Reactome:R-HSA-380586|Reactome:R-HSA-379393|Reactome:R-HSA-380620|Reactome:R-HSA-444160|Reactome:R-HSA-372542 molecular_function owl:Class
GO:0061632 biolink:NamedThing RNA lariat debranching enzyme activator activity Increases the activity of an enzyme that catalyzes the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide. got7fsn_ti dph 2014-06-17T10:07:31Z molecular_function owl:Class
GO:0050545 biolink:NamedThing sulfopyruvate decarboxylase activity Catalysis of the reaction: 3-sulfopyruvate + H(+) = CO(2) + sulfoacetaldehyde. got7fsn_ti sulfopyruvate carboxy-lyase (2-sulfoacetaldehyde-forming)|sulfopyruvate carboxy-lyase activity|sulphopyruvate decarboxylase activity RHEA:20948|EC:4.1.1.79|KEGG_REACTION:R05774|MetaCyc:R231-RXN molecular_function owl:Class
GO:0008832 biolink:NamedThing dGTPase activity Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate. got7fsn_ti deoxy-GTPase activity|deoxyguanosinetriphosphate triphosphohydrolase activity|dGTP triphosphohydrolase activity|deoxyguanosine triphosphatase activity|deoxyguanosine 5-triphosphate triphosphohydrolase activity|deoxyguanosine triphosphate triphosphohydrolase activity EC:3.1.5.1|MetaCyc:DGTPTRIPHYDRO-RXN|RHEA:15193|KEGG_REACTION:R01856 molecular_function owl:Class
GO:0102922 biolink:NamedThing phenylpropanoyltransferase activity Catalysis of the reaction: baccatin III + (3R)-3-amino-3-phenylpropanoyl-CoA = N-debenzoyl-(3'-RS)-2'-deoxytaxol + coenzyme A. got7fsn_ti MetaCyc:RXN-8857|RHEA:42488 molecular_function owl:Class
GO:0002319 biolink:NamedThing memory B cell differentiation The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody. got7fsn_ti memory B-lymphocyte differentiation|memory B lymphocyte differentiation|memory B-cell differentiation|memory B cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0032305 biolink:NamedThing positive regulation of icosanoid secretion Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell. got7fsn_ti stimulation of icosanoid secretion|up-regulation of icosanoid secretion|positive regulation of eicosanoid secretion|activation of icosanoid secretion|up regulation of icosanoid secretion|upregulation of icosanoid secretion biological_process owl:Class
GO:2000193 biolink:NamedThing positive regulation of fatty acid transport Any process that activates or increases the frequency, rate or extent of fatty acid transport. got7fsn_ti rl 2010-10-18T10:37:17Z biological_process owl:Class
GO:0008852 biolink:NamedThing exodeoxyribonuclease I activity Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. got7fsn_ti E. coli exonuclease I|Escherichia coli exonuclease I|exonuclease I activity|E. coli exonuclease I activity MetaCyc:3.1.11.1-RXN|EC:3.1.11.1 molecular_function owl:Class
GO:0061381 biolink:NamedThing cell migration in diencephalon The orderly movement of a cell that will reside in the diencephalon. got7fsn_ti dph 2010-11-09T09:54:27Z biological_process owl:Class
GO:0017134 biolink:NamedThing fibroblast growth factor binding Binding to a fibroblast growth factor. got7fsn_ti fibroblast growth factor 6 binding|fibroblast growth factor 5 binding|FGF 4 binding|fibroblast growth factor 3 binding|FGF 3 binding|FGF 2 binding|FGF 5 binding|fibroblast growth factor 2 binding|FGF binding|FGF 1 binding|fibroblast growth factor 1 binding|FGF 6 binding|fibroblast growth factor 4 binding GO:0048606|GO:0048602|GO:0048607|GO:0048605|GO:0048604|GO:0048603 molecular_function owl:Class
GO:0042981 biolink:NamedThing regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process. got7fsn_ti apoptosis regulator activity|regulation of apoptosis This term should only be used when it is not possible to determine which phase or subtype of the apoptotic process is regulated by a gene product. Whenever detailed information is available, the more granular children terms should be used. biological_process owl:Class
GO:0016994 biolink:NamedThing precorrin-6A reductase activity Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+. got7fsn_ti precorrin-6Y:NADP+ oxidoreductase activity|precorrin-6Y:NADP(+) oxidoreductase activity|precorrin-6X reductase activity|precorrin-6B:NADP+ oxidoreductase activity EC:1.3.1.54|RHEA:23408|MetaCyc:1.3.1.54-RXN molecular_function owl:Class
GO:0090118 biolink:NamedThing receptor-mediated endocytosis involved in cholesterol transport A receptor-mediated endocytosis process involved in intracellular cholesterol transport. got7fsn_ti receptor-mediated endocytosis of LDL|receptor-mediated endocytosis of low-density lipoprotein involved in cholesterol transport|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|receptor-mediated endocytosis involved in intracellular cholesterol transport tb 2009-12-07T12:06:05Z biological_process owl:Class
GO:0097168 biolink:NamedThing mesenchymal stem cell proliferation The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells. got7fsn_ti MSC proliferation pr 2011-09-29T04:44:48Z biological_process owl:Class
GO:0032410 biolink:NamedThing negative regulation of transporter activity Any process that stops or reduces the activity of a transporter. got7fsn_ti down regulation of transporter activity|downregulation of transporter activity|inhibition of transporter activity|down-regulation of transporter activity biological_process owl:Class
GO:0004720 biolink:NamedThing protein-lysine 6-oxidase activity Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. got7fsn_ti protein-L-lysine:oxygen 6-oxidoreductase (deaminating)|lysyl oxidase activity GO:0018056 EC:1.4.3.13|Reactome:R-HSA-2002466|MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN|Reactome:R-HSA-2395340|RHEA:24544|Reactome:R-HSA-2129375 molecular_function owl:Class
GO:0102056 biolink:NamedThing 11-hydroxyjasmonate sulfotransferase activity Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + an 11-hydroxyjasmonate <=> adenosine 3',5'-bismonophosphate + H+ + an 11-hydroxyjasmonate sulfate. got7fsn_ti RHEA:52732|MetaCyc:RXN-10453|EC:2.8.2.39 molecular_function owl:Class
GO:0008963 biolink:NamedThing phospho-N-acetylmuramoyl-pentapeptide-transferase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. got7fsn_ti MraY transferase activity|UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity|phospho-MurNAc-pentapeptide transferase activity|UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity|phosphoacetylmuramoylpentapeptide translocase activity|phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity|UDP-MurNAc-pentapeptide phosphotransferase activity|UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity|UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity|UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity|phospho-N-acetylmuramoyl pentapeptide translocase activity|phosphoacetylmuramoylpentapeptidetransferase activity Note that EC classifies all three 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under EC:2.7.8.13. MetaCyc:RXN-8975|EC:2.7.8.13|RHEA:21920 molecular_function owl:Class
GO:0008868 biolink:NamedThing galactitol-1-phosphate 5-dehydrogenase activity Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+. got7fsn_ti galactitol-1-phosphate:NAD+ oxidoreductase activity EC:1.1.1.251|MetaCyc:1.1.1.251-RXN|RHEA:15137 molecular_function owl:Class
GO:0060264 biolink:NamedThing regulation of respiratory burst involved in inflammatory response Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. got7fsn_ti regulation of respiratory burst involved in acute inflammatory response biological_process owl:Class
GO:0045088 biolink:NamedThing regulation of innate immune response Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. got7fsn_ti biological_process owl:Class
GO:0010041 biolink:NamedThing response to iron(III) ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus. got7fsn_ti response to iron(III) biological_process owl:Class
GO:0003409 biolink:NamedThing optic cup structural organization The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure. got7fsn_ti optic cup structural organisation dph 2009-12-21T02:44:20Z biological_process owl:Class
GO:0016710 biolink:NamedThing trans-cinnamate 4-monooxygenase activity Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O. got7fsn_ti hydroxylase, cinnamate 4-|cinnamic acid p-hydroxylase activity|cinnamate hydroxylase activity|cinnamate 4-monooxygenase activity|cinnamic 4-hydroxylase activity|t-cinnamic acid hydroxylase activity|CA4H activity|cinnamic acid 4-hydroxylase activity|oxygenase, cinnamate 4-mono-|cinnamate 4-hydroxylase activity|trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)|trans-cinnamic acid 4-hydroxylase activity|trans-cinnamate 4-hydroxylase activity|cytochrome P450 cinnamate 4-hydroxylase activity|cinnamic acid 4-monooxygenase activity MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN|EC:1.14.14.91|RHEA:10608 molecular_function owl:Class
GO:0060238 biolink:NamedThing regulation of signal transduction involved in conjugation with cellular fusion Any process that modulates the rate, frequency or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion. got7fsn_ti biological_process owl:Class
GO:0003870 biolink:NamedThing 5-aminolevulinate synthase activity Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA. got7fsn_ti succinyl-CoA:glycine C-succinyltransferase (decarboxylating)|delta-aminolevulinic synthetase activity|delta-aminolevulinate synthase activity|delta-ALA synthetase activity|delta-aminolevulinic acid synthetase activity|alpha-aminolevulinic acid synthase activity|aminolevulinate synthase activity|aminolevulinate synthetase activity|ALA synthetase activity|aminolevulinic acid synthetase activity|5-aminolevulinic acid synthetase activity|delta-aminolevulinic acid synthase activity|aminolevulinic synthetase activity|ALA synthase activity|ALAS activity|delta-aminolevulinate synthetase activity|5-aminolevulinate synthetase activity|aminolevulinic acid synthase activity|5-aminolevulinic acid synthase activity EC:2.3.1.37|Reactome:R-HSA-189442|RHEA:12921|KEGG_REACTION:R00830|MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN molecular_function owl:Class
GO:0031225 biolink:NamedThing anchored component of membrane The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. got7fsn_ti anchored to membrane cellular_component owl:Class
GO:0036299 biolink:NamedThing non-recombinational interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination. got7fsn_ti recombination-independent interstrand cross-link repair|recombination-independent ICL repair bf 2012-08-07T11:11:59Z biological_process owl:Class
GO:0090712 biolink:NamedThing basal pole of outer hair cell The end of the outer hair cell which receives and transmits neural signals. got7fsn_ti tb 2016-11-01T12:57:03Z cellular_component owl:Class
GO:0044074 biolink:NamedThing negative regulation by symbiont of host translation The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism. got7fsn_ti negative regulation of host translation by symbiont biological_process owl:Class
GO:0044073 biolink:NamedThing modulation by symbiont of host translation The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism. got7fsn_ti modification by symbiont of host translation|modulation of host translation by symbiont|regulation by symbiont of host translation biological_process owl:Class
GO:0008779 biolink:NamedThing acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine. got7fsn_ti acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity|acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity|acyl-ACP-phospholipid O-acyltransferase activity|acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity RHEA:10304|MetaCyc:ACYLGPEACYLTRANS-RXN|EC:2.3.1.40 molecular_function owl:Class
GO:0030838 biolink:NamedThing positive regulation of actin filament polymerization Any process that activates or increases the frequency, rate or extent of actin polymerization. got7fsn_ti stimulation of actin filament polymerization|up-regulation of actin filament polymerization|positive regulation of actin polymerization and/or depolymerization|positive regulation of actin polymerization|up regulation of actin filament polymerization|upregulation of actin filament polymerization|activation of actin filament polymerization Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836'). biological_process owl:Class
GO:0099096 biolink:NamedThing vestibular calyx terminal The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell. got7fsn_ti cellular_component owl:Class
GO:0051083 biolink:NamedThing 'de novo' cotranslational protein folding The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. got7fsn_ti multidomain protein assembly|nascent polypeptide association|'de novo' co-translational protein folding GO:0006444 biological_process owl:Class
GO:0052756 biolink:NamedThing chitobiose phosphorylase activity Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units. got7fsn_ti ai 2011-09-27T04:04:53Z molecular_function owl:Class
GO:0006534 biolink:NamedThing cysteine metabolic process The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. got7fsn_ti cysteine metabolism Wikipedia:Cysteine_metabolism biological_process owl:Class
GO:0018567 biolink:NamedThing styrene dioxygenase activity Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0256 molecular_function owl:Class
GO:2000944 biolink:NamedThing positive regulation of amylopectin metabolic process Any process that activates or increases the frequency, rate or extent of amylopectin metabolic process. got7fsn_ti positive regulation of Amylopectin metabolism tt 2011-08-01T02:10:36Z biological_process owl:Class
GO:0032990 biolink:NamedThing cell part morphogenesis The process in which the anatomical structures of a cell part are generated and organized. got7fsn_ti biological_process owl:Class
GO:0047695 biolink:NamedThing benzoin aldolase activity Catalysis of the reaction: benzoin = 2 benzaldehyde. got7fsn_ti benzaldehyde lyase activity|2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2- activity|2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase activity|diphenylethanone benzaldehyde-lyase activity|2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase 2-hydroxy-1,2-diphenylethanone benzaldehyde-lyase (benzaldehyde-forming) RHEA:21460|MetaCyc:BENZOIN-ALDOLASE-RXN|EC:4.1.2.38|KEGG_REACTION:R00027 molecular_function owl:Class
GO:0061270 biolink:NamedThing mesonephric intraglomerular mesangial cell proliferation The multiplication or reproduction of intraglomerular glomerular mesangium cells in the mesonephros by cell division, resulting in the expansion of their population. Intraglomerular mesangial cells are specialized pericytes located among the glomerular capillaries within a renal corpuscle of a kidney. They are required for filtration, structural support and phagocytosis. got7fsn_ti dph 2010-08-30T03:23:10Z biological_process owl:Class
GO:0098786 biolink:NamedThing biofilm matrix disassembly A process that results in the disassembly of a biofilm matrix. got7fsn_ti biological_process owl:Class
GO:0039717 biolink:NamedThing spherule viral factory A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus. got7fsn_ti bf 2013-12-19T15:25:57Z Wikipedia:Viroplasm cellular_component owl:Class
GO:0102232 biolink:NamedThing acrolein reductase activity Catalysis of the reaction: acrolein + NADPH + H+ <=> propanal + NADP. got7fsn_ti MetaCyc:RXN-12281 molecular_function owl:Class
GO:0033910 biolink:NamedThing glucan 1,4-alpha-maltotetraohydrolase activity Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in amylaceous polysaccharides, to remove successive maltotetraose residues from the non-reducing chain ends. got7fsn_ti maltotetraose-forming amylase activity|G4-amylase activity|exo-maltotetraohydrolase activity|glucan 1,4-alpha-maltotetrahydrolase activity|1,4-alpha-D-glucan maltotetraohydrolase activity EC:3.2.1.60|MetaCyc:3.2.1.60-RXN molecular_function owl:Class
GO:0035509 biolink:NamedThing negative regulation of myosin-light-chain-phosphatase activity Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity. got7fsn_ti bf 2010-04-30T10:56:34Z biological_process owl:Class
GO:0016162 biolink:NamedThing cellulose 1,4-beta-cellobiosidase activity Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains. got7fsn_ti beta-1,4-glucan cellobiohydrolase activity|exoglucanase activity|avicelase activity|1,4-beta-D-glucan cellobiohydrolase activity|cellobiohydrolase activity|CBH 1|cellobiosidase activity|cellobiohydrolase I|1,4-beta-glucan cellobiosidase activity|C1 cellulase activity|exo-1,4-beta-D-glucanase activity|exocellobiohydrolase activity|exo-cellobiohydrolase activity|exo-beta-1,4-glucan cellobiohydrolase activity|1,4-beta-cellobiohydrolase activity|beta-1,4-glucan cellobiosylhydrolase activity MetaCyc:3.2.1.91-RXN|EC:3.2.1.91 molecular_function owl:Class
GO:0090551 biolink:NamedThing response to manganese starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of manganese. got7fsn_ti tb 2013-04-22T13:57:16Z biological_process owl:Class
GO:0140066 biolink:NamedThing peptidyl-lysine crotonylation The crotonylation of a lysine residue in a protein. Crotonyl is the univalent radical CH3-CH=CH-CO- derived from crotonic acid. got7fsn_ti pg 2017-07-20T16:48:58Z biological_process owl:Class
GO:0032190 biolink:NamedThing acrosin binding Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. got7fsn_ti acrosin heavy chain binding|acrosin light chain binding GO:0032192|GO:0032191 molecular_function owl:Class
GO:0031732 biolink:NamedThing CCR7 chemokine receptor binding Binding to a CCR7 chemokine receptor. got7fsn_ti type 1 EBV-induced G-protein coupled receptor binding|MIP-3 beta receptor binding|CCR7 chemokine receptor ligand molecular_function owl:Class
GO:0071267 biolink:NamedThing L-methionine salvage Any process that generates L-methionine from derivatives of it, without de novo synthesis. got7fsn_ti mah 2009-12-09T04:36:49Z biological_process owl:Class
GO:0060838 biolink:NamedThing lymphatic endothelial cell fate commitment The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell. got7fsn_ti dph 2009-08-11T03:51:45Z biological_process owl:Class
GO:0016984 biolink:NamedThing ribulose-bisphosphate carboxylase activity Catalysis of the reaction: 2 (2R)-3-phosphoglycerate + 2 H+ = CO2 + D-ribulose 1,5-bisphosphate + H2O. got7fsn_ti ribulose diphosphate carboxylase activity|ribulose 1,5-bisphosphate carboxylase activity|diphosphoribulose carboxylase activity|ribulose 1,5-diphosphate carboxylase activity|carboxydismutase activity|rubisco activity|D-ribulose 1,5-diphosphate carboxylase activity|ribulose diphosphate carboxylase/oxygenase activity|RuBP carboxylase activity|RuBisCO activity|ribulose 1,5-diphosphate carboxylase/oxygenase activity|D-ribulose-1,5-bisphosphate carboxylase activity|ribulose bisphosphate carboxylase/oxygenase activity|ribulose 1,5-bisphosphate carboxylase/oxygenase activity MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN|RHEA:23124|EC:4.1.1.39 molecular_function owl:Class
GO:0102998 biolink:NamedThing 4-sulfomuconolactone hydrolase activity Catalysis of the reaction: (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate + H2O <=> maleylacetate + sulfite + 2 H+. got7fsn_ti RHEA:33711|EC:3.1.1.92|MetaCyc:RXN-9733 molecular_function owl:Class
GO:0050143 biolink:NamedThing nocardicin-A epimerase activity Catalysis of the reaction: isonocardicin A = nocardicin A. got7fsn_ti isonocardicin A epimerase activity RHEA:22792|KEGG_REACTION:R03073|EC:5.1.1.14|MetaCyc:NOCARDICIN-A-EPIMERASE-RXN molecular_function owl:Class
GO:1990063 biolink:NamedThing Bam protein complex Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex. got7fsn_ti OMP complex bhm 2013-03-20T15:42:57Z cellular_component owl:Class
GO:0004488 biolink:NamedThing methylenetetrahydrofolate dehydrogenase (NADP+) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH. got7fsn_ti 5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity|5,10-methylenetetrahydrofolate:NADP oxidoreductase activity RHEA:22812|EC:1.5.1.5|MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN|KEGG_REACTION:R01220 molecular_function owl:Class
GO:0033827 biolink:NamedThing high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity Catalysis of the transfer of an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-1,6 to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum. got7fsn_ti acetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase activity|UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase activity EC:2.4.1.197|MetaCyc:2.4.1.197-RXN molecular_function owl:Class
GO:0043436 biolink:NamedThing oxoacid metabolic process The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). got7fsn_ti oxoacid metabolism|keto acid metabolic process|ketoacid metabolic process|ketoacid metabolism|keto acid metabolism|oxo acid metabolism|oxo acid metabolic process biological_process owl:Class
GO:0097548 biolink:NamedThing seed abscission The controlled shedding of a seed. got7fsn_ti pr 2014-01-22T07:57:41Z biological_process owl:Class
GO:0005689 biolink:NamedThing U12-type spliceosomal complex Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site. got7fsn_ti minor (U12-type) spliceosomal complex|minor spliceosomal complex|AT-AC spliceosomal complex Wikipedia:Minor_spliceosome cellular_component owl:Class
GO:0043200 biolink:NamedThing response to amino acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. got7fsn_ti response to amino acid stimulus GO:0010237 biological_process owl:Class
GO:0047347 biolink:NamedThing aldose-1-phosphate nucleotidyltransferase activity Catalysis of the reaction: aldose 1-phosphate + NDP = phosphate + NDP-aldose. got7fsn_ti sugar nucleotide phosphorylase activity|NDP sugar phosphorylase activity|nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase activity|nucleoside diphosphosugar phosphorylase activity|NDP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity|sugar phosphate nucleotidyltransferase activity|NDP-aldose phosphorylase activity|glucose 1-phosphate inosityltransferase activity|NDP:aldose-1-phosphate nucleotidyltransferase activity|NDP-sugar phosphorylase activity|NDPaldose phosphorylase activity|sugar-1-phosphate nucleotidyltransferase activity MetaCyc:2.7.7.37-RXN|EC:2.7.7.37 molecular_function owl:Class
GO:0050550 biolink:NamedThing pinene synthase activity Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate. got7fsn_ti geranyl-diphosphate diphosphate-lyase (cyclizing, pinene-forming)|(-)-(1S,5S)-pinene synthase activity|geranyldiphosphate diphosphate lyase (pinene forming)|beta-geraniolene synthase activity EC:4.2.3.14|MetaCyc:4.2.3.14-RXN molecular_function owl:Class
GO:0047440 biolink:NamedThing 2-dehydro-3-deoxy-D-pentonate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate. got7fsn_ti 2-dehydro-3-deoxy-D-pentonate glycolaldehyde-lyase activity|2-keto-3-deoxy-D-pentonate aldolase activity|3-deoxy-D-pentulosonic acid aldolase EC:4.1.2.28|MetaCyc:4.1.2.28-RXN|KEGG_REACTION:R01782|RHEA:20609 molecular_function owl:Class
GO:0005844 biolink:NamedThing polysome A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro. got7fsn_ti polyribosome Wikipedia:Polysome|NIF_Subcellular:sao1038025871 cellular_component owl:Class
GO:0008453 biolink:NamedThing alanine-glyoxylate transaminase activity Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine. got7fsn_ti alanine-glyoxylate aminotransferase activity|AGT activity|L-alanine:glyoxylate aminotransferase activity|alanine--glyoxylate aminotransferase activity|alanine-glyoxylic aminotransferase activity|L-alanine-glycine transaminase activity Reactome:R-HSA-904864|EC:2.6.1.44|Reactome:R-HSA-389684|RHEA:24248|MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:0033994 biolink:NamedThing glucuronan lyase activity Catalysis of the reaction: (1->4)-beta-D-glucuronan = an oligosaccharide with 4-deoxy-beta-D-gluc-4-enuronosyl end + (1->4)-beta-D-glucuronan. This reaction is the eliminative cleavage of (1->4)-beta-D-glucuronans to give oligosaccharides with 4-deoxy-beta-D-gluc-4-enuronosyl groups at their non-reducing ends. Complete degradation of glucuronans results in the formation of tetrasaccharides. got7fsn_ti (1,4)-beta-D-glucuronan lyase activity EC:4.2.2.14|MetaCyc:4.2.2.14-RXN molecular_function owl:Class
GO:0032595 biolink:NamedThing B cell receptor transport within lipid bilayer The directed movement of a B cell receptor within a lipid bilayer. got7fsn_ti BCR translocation within membrane|BCR transport within lipid bilayer|B cell receptor translocation within membrane biological_process owl:Class
GO:0045695 biolink:NamedThing negative regulation of embryo sac egg cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac egg cell differentiation. got7fsn_ti negative regulation of female gametophyte egg cell differentiation|inhibition of female gametophyte egg cell differentiation|down regulation of female gametophyte egg cell differentiation|downregulation of female gametophyte egg cell differentiation|down-regulation of female gametophyte egg cell differentiation biological_process owl:Class
GO:0075070 biolink:NamedThing adhesion of symbiont hyphopodium to host The attachment of a hyphopodium of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti adhesion of symbiont hyphopodium to host during symbiotic interaction Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0031552 biolink:NamedThing negative regulation of brain-derived neurotrophic factor-activated receptor activity Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity. got7fsn_ti negative regulation of BDNF receptor activity|inhibition of brain-derived neurotrophic factor receptor activity|down-regulation of brain-derived neurotrophic factor receptor activity|downregulation of brain-derived neurotrophic factor receptor activity|down regulation of brain-derived neurotrophic factor receptor activity|negative regulation of brain-derived neurotrophic factor receptor activity biological_process owl:Class
GO:0031549 biolink:NamedThing negative regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. got7fsn_ti down-regulation of brain-derived neurotrophic factor receptor signaling pathway|inhibition of brain-derived neurotrophic factor receptor signaling pathway|down regulation of brain-derived neurotrophic factor receptor signaling pathway|negative regulation of BDNF receptor signaling pathway|downregulation of brain-derived neurotrophic factor receptor signaling pathway|negative regulation of brain-derived neurotrophic factor receptor signalling pathway|negative regulation of BDNF receptor signalling pathway biological_process owl:Class
GO:0048494 biolink:NamedThing chromatophore ribulose bisphosphate carboxylase complex A complex, located in the chromatophore, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. got7fsn_ti RubisCO complex cellular_component owl:Class
GO:0075139 biolink:NamedThing response to host iron concentration Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting iron concentration in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response of symbiont to host iron concentration Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class
GO:0097587 biolink:NamedThing MutLgamma complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3. got7fsn_ti pr 2014-03-06T11:48:12Z cellular_component owl:Class
GO:0033416 biolink:NamedThing UGG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UGG codon. got7fsn_ti TGG codon-amino acid adaptor activity|tryptophan tRNA Note that in the standard genetic code, TGG codes for tryptophan. molecular_function owl:Class
GO:0010358 biolink:NamedThing leaf shaping The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed. got7fsn_ti leaf structural organization biological_process owl:Class
GO:0047188 biolink:NamedThing aromatic-hydroxylamine O-acetyltransferase activity Catalysis of the reaction: N-hydroxy-4-aminobiphenyl + N-hydroxy-4-acetylaminonbiphenyl = N-acetoxy-4-aminobiphenyl + N-hydroxy-4-aminobiphenyl. got7fsn_ti N,O-acetyltransferase activity|arylhydroxamic acid N,O-acetyltransferase activity|arylhydroxamic acyltransferase activity|aromatic hydroxylamine acetyltransferase activity|arylhydroxamate acyltransferase activity|N-hydroxy-2-acetylaminofluorene N-O acyltransferase activity|N-hydroxy-4-acetylaminobiphenyl:N-hydroxy-4-aminobiphenyl O-acetyltransferase activity RHEA:20325|EC:2.3.1.56|MetaCyc:2.3.1.56-RXN molecular_function owl:Class
GO:0004523 biolink:NamedThing RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. got7fsn_ti hybrid nuclease activity|hybridase (ribonuclease H)|RNase H3 activity|RNase H activity|calf thymus ribonuclease H activity|ribonuclease H3 activity|RNase H1 activity|hybridase activity|ribonuclease H activity|endoribonuclease H|RNA*DNA hybrid ribonucleotidohydrolase activity|ribonuclease H2 activity|hybrid ribonuclease activity|ribonuclease H1 activity|endoribonuclease H (calf thymus)|RNase H2 activity|endoribonuclease0 H activity Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. GO:0004524 Reactome:R-HSA-164528|Reactome:R-HSA-173769|Reactome:R-HSA-164519|Reactome:R-HSA-182859|EC:3.1.26.4|MetaCyc:3.1.26.4-RXN|Reactome:R-HSA-182795 molecular_function owl:Class
GO:0102861 biolink:NamedThing 1-18:2-2-18:1-phosphatidylcholine desaturase activity (SN2-18:2 forming) Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8328|EC:1.14.19.22 molecular_function owl:Class
GO:0030409 biolink:NamedThing glutamate formimidoyltransferase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate. got7fsn_ti formimidoyltransferase activity|glutamate formyltransferase activity|formiminoglutamic formiminotransferase activity|glutamate formiminotransferase activity|formiminoglutamic acid transferase activity|5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity|formiminotransferase activity https://github.com/geneontology/go-ontology/issues/20486 GO:0030407 RHEA:15097|MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN|EC:2.1.2.5 molecular_function owl:Class
GO:0044180 biolink:NamedThing filamentous growth of a unicellular organism The process in which a unicellular organism grows in a threadlike, filamentous shape. got7fsn_ti jl 2009-09-25T10:16:01Z biological_process owl:Class
GO:0071678 biolink:NamedThing olfactory bulb axon guidance The process in which the migration of an axon growth cone of a neuron in the olfactory bulb is directed to its target in the brain in response to a combination of attractive and repulsive cues. got7fsn_ti olfactory bulb axon pathfinding mah 2010-02-17T02:09:34Z biological_process owl:Class
GO:0009392 biolink:NamedThing N-acetyl-anhydromuramoyl-L-alanine amidase activity Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala. got7fsn_ti MetaCyc:RXN0-5225 molecular_function owl:Class
GO:0050612 biolink:NamedThing arsenate reductase (donor) activity Catalysis of the reaction: A + arsenite + H(2)O = AH(2) + arsenate + 2 H(+). got7fsn_ti arsenate:acceptor oxidoreductase activity|arsenate:(acceptor) oxidoreductase activity KEGG_REACTION:R05752|RHEA:18449|EC:1.20.99.1|MetaCyc:1.20.99.1-RXN molecular_function owl:Class
GO:0070837 biolink:NamedThing dehydroascorbic acid transport The directed movement of dehydroascorbate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, is an oxidized form of vitamin C. got7fsn_ti dehydroascorbate transport mah 2009-07-30T05:24:31Z biological_process owl:Class
GO:0002410 biolink:NamedThing plasmacytoid dendritic cell chemotaxis The movement of a plasmacytoid dendritic cell in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0072184 biolink:NamedThing renal vesicle progenitor cell differentiation The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the renal vesicle progenitor cells of the kidney as it progresses from its formation to the mature state. A renal vesicle progenitor cell is a cell that will give rise to terminally differentiated cells of the renal vesicle without self-renewing. got7fsn_ti mah 2010-02-26T02:52:54Z biological_process owl:Class
GO:0097321 biolink:NamedThing cell growth mode switching, filamentous to budding The process in which a cell switches from growing as a filament (elongated cells attached end-to-end) to growing as a round budding cell. An example of this is observed in Candida albicans. got7fsn_ti pr 2012-06-05T11:28:06Z biological_process owl:Class
GO:0070784 biolink:NamedThing regulation of growth of unicellular organism as a thread of attached cells Any process that modulates the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium. got7fsn_ti mah 2009-07-07T02:34:59Z biological_process owl:Class
GO:0034843 biolink:NamedThing 2-oxoglutaryl-CoA thioesterase activity Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH. got7fsn_ti UM-BBD_reactionID:r1238 molecular_function owl:Class
GO:0102257 biolink:NamedThing 1-16:0-2-18:2-phosphatidylcholine sn-1 acylhydrolase activity Catalysis of the reaction: 1-palmitoyl-2-linoleoyl-phosphatidylcholine + H2O <=> 1-linoleoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+. got7fsn_ti MetaCyc:RXN-12430 molecular_function owl:Class
GO:0140417 biolink:NamedThing ATP-sensitive calcium-release channel activity Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a ATP has been bound by the channel complex or one of its constituent parts. got7fsn_ti pg 2020-01-27T09:22:04Z molecular_function owl:Class
GO:1902224 biolink:NamedThing ketone body metabolic process The chemical reactions and pathways involving ketone body. got7fsn_ti ketone body metabolism pr 2013-06-13T10:37:54Z biological_process owl:Class
GO:0001601 biolink:NamedThing peptide YY receptor activity Combining with gut peptide YY to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0050600 biolink:NamedThing myristoyl-CoA 11-(E) desaturase activity Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O. got7fsn_ti n-tetradecanoyl-CoA,NADPH:O2 oxidoreductase [11-(E) desaturating]|n-tetradecanoyl-CoA,NAD(P)H:O2 oxidoreductase [11-(E) desaturating] RHEA:46396|EC:1.14.19.24|MetaCyc:1.14.99.31-RXN molecular_function owl:Class
GO:0103050 biolink:NamedThing isobutyraldehyde reductase activity Catalysis of the reaction: isobutanol + NADP <=> isobutyraldehyde + NADPH + H+. got7fsn_ti MetaCyc:RXN0-7119 molecular_function owl:Class
GO:0034749 biolink:NamedThing Scrib-APC complex A protein complex that contains the Scribble protein (a cell polarity determinant) and the tumor suppressor protein adenomatous polyposis coli (APC); may be involved in the control of cell proliferation. got7fsn_ti hScrib-APC complex Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0046773 biolink:NamedThing suppression by virus of host translation termination Any viral process that stops, prevents, or reduces the frequency, rate or extent of translational termination of a host mRNA. got7fsn_ti negative regulation by virus of host cell protein biosynthetic process shutoff|viral inhibition of termination of host cell protein biosynthetic process|viral inhibition of host cell protein biosynthesis shutoff|suppression by virus of host termination of protein biosynthetic process|viral suppression of termination by host of host cell protein biosynthetic process|viral inhibition of termination of host cell protein biosynthesis|viral inhibition of host cell protein biosynthetic process shutoff|viral suppression of termination by host of host cell protein biosynthesis|negative regulation by virus of host cell protein biosynthesis shutoff biological_process owl:Class
GO:0031468 biolink:NamedThing nuclear membrane reassembly The reformation of the nuclear membranes following their breakdown in the context of a normal process. got7fsn_ti nuclear envelope reassembly https://github.com/geneontology/go-ontology/issues/20636 biological_process owl:Class
GO:0140368 biolink:NamedThing decoy receptor complex A receptor complex that recognizes, binds and sequesters a specific receptor ligand to prevent it from binding to its regular receptor. May be soluble or membrane bound. got7fsn_ti osteoclastogenesis inhibitory factor|osteoprotegerin complex pg 2019-09-13T16:39:24Z cellular_component owl:Class
GO:2001137 biolink:NamedThing positive regulation of endocytic recycling Any process that activates or increases the frequency, rate or extent of endocytic recycling. got7fsn_ti positive regulation of retrograde transport of endocytic vesicles kmv 2011-10-14T03:34:49Z biological_process owl:Class
GO:0015503 biolink:NamedThing glutathione-regulated potassium exporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state. got7fsn_ti molecular_function owl:Class
GO:0006296 biolink:NamedThing nucleotide-excision repair, DNA incision, 5'-to lesion The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage. got7fsn_ti nucleotide-excision repair, DNA incision, 5' to lesion biological_process owl:Class
GO:0061615 biolink:NamedThing glycolytic process through fructose-6-phosphate The chemical reactions and pathways resulting in the breakdown of a monosaccharide into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH. got7fsn_ti glycolysis through fructose-6-phosphate dph 2014-04-08T10:08:49Z MetaCyc:PWY-5484 biological_process owl:Class
GO:0071172 biolink:NamedThing dihydromonapterin reductase activity Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+. got7fsn_ti mah 2009-11-23T11:10:17Z molecular_function owl:Class
GO:0102589 biolink:NamedThing cyanidin 3-O-glucoside 3'',6''-O-dimalonyltransferase activity Catalysis of the reaction: cyanidin 3-O-(6-O-malonyl-beta-D-glucoside) + malonyl-CoA(5-) <=> cyanidin 3-O-(3''', 6''-O-dimalonyl-beta-glucopyranoside) + coenzyme A. got7fsn_ti MetaCyc:RXN-15336 molecular_function owl:Class
GO:0035693 biolink:NamedThing NOS2-CD74 complex A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases. got7fsn_ti bf 2011-02-25T11:35:38Z cellular_component owl:Class
GO:0018180 biolink:NamedThing protein desulfurization The removal of a sulfur group from a protein amino acid. got7fsn_ti protein amino acid desulfurization|protein amino acid desulfurisation|protein amino acid desulphurisation|protein amino acid desulphurization biological_process owl:Class
GO:0034936 biolink:NamedThing 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0959 molecular_function owl:Class
GO:0018636 biolink:NamedThing phenanthrene 9,10-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide. got7fsn_ti UM-BBD_reactionID:r0495|EC:1.14.13.- molecular_function owl:Class
GO:0061441 biolink:NamedThing renal artery morphogenesis The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood. got7fsn_ti dph 2012-03-08T12:42:09Z biological_process owl:Class
GO:0030554 biolink:NamedThing adenyl nucleotide binding Binding to an adenyl nucleotide, an adenosine esterified with (ortho)phosphate. got7fsn_ti molecular_function owl:Class
GO:0140703 biolink:NamedThing 3',3'-cyclic GMP-AMP binding Binding to 3',3' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 3',5' linkages. got7fsn_ti 3',3'-cGMP-AMP binding|3',3'-cGAMP binding|3',3'-cyclic GAMP binding|3',3' cyclic-GMP-AMP binding https://github.com/geneontology/go-ontology/issues/21980 pg 2021-08-27T05:44:15Z molecular_function owl:Class
GO:0030551 biolink:NamedThing cyclic nucleotide binding Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. got7fsn_ti molecular_function owl:Class
GO:0070653 biolink:NamedThing high-density lipoprotein particle receptor binding Binding to a high-density lipoprotein receptor. got7fsn_ti high-density lipoprotein receptor binding|HDL receptor binding mah 2009-05-28T03:44:33Z molecular_function owl:Class
GO:0039501 biolink:NamedThing suppression by virus of host type I interferon production Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti negative regulation by virus of host type I interferon production|suppression by virus of host type I IFN production|suppression by virus of host interferon type I production bf 2011-05-11T03:53:20Z VZ:875 biological_process owl:Class
GO:0032480 biolink:NamedThing negative regulation of type I interferon production Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. got7fsn_ti inhibition of type I interferon production|down regulation of type I interferon production|downregulation of type I interferon production|negative regulation of type I IFN production|down-regulation of type I interferon production biological_process owl:Class
GO:0002337 biolink:NamedThing B-1a B cell differentiation The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors. got7fsn_ti B-1a B-lymphocyte differentiation|B-1a B lymphocyte differentiation|B-1a B cell development|B-1a B-cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0071321 biolink:NamedThing cellular response to cGMP Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. got7fsn_ti cellular response to 3',5' cGMP|cellular response to 3',5'-cGMP|cellular response to cyclic GMP|cellular response to guanosine 3',5'-cyclophosphate mah 2009-12-10T05:12:58Z biological_process owl:Class
GO:0070305 biolink:NamedThing response to cGMP Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cGMP (cyclic GMP, guanosine 3',5'-cyclophosphate) stimulus. got7fsn_ti response to 3',5'-cGMP|response to guanosine 3',5'-cyclophosphate|response to 3',5' cGMP|response to cyclic GMP biological_process owl:Class
GO:0010291 biolink:NamedThing carotene beta-ring hydroxylase activity Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene. got7fsn_ti beta-carotene hydroxylase activity GO:0042411 molecular_function owl:Class
GO:0042124 biolink:NamedThing 1,3-beta-glucanosyltransferase activity Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation. got7fsn_ti molecular_function owl:Class
GO:0070481 biolink:NamedThing nuclear-transcribed mRNA catabolic process, non-stop decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon. got7fsn_ti non-stop mRNA decay|non-stop decay|nonstop mRNA decay|nuclear-transcribed mRNA catabolism, non-stop decay|nuclear-transcribed mRNA degradation, non-stop decay|nuclear-transcribed mRNA breakdown, non-stop decay biological_process owl:Class
GO:0035106 biolink:NamedThing operant conditioning Learning to anticipate future events on the basis of past experience with the consequences of one's own behavior. got7fsn_ti instrumental conditioning Wikipedia:Operant_conditioning biological_process owl:Class
GO:0047004 biolink:NamedThing UDP-N-acetylglucosamine 6-dehydrogenase activity Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-N-acetyl-alpha-D-glucosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate. got7fsn_ti UDP-GLcNAc dehydrogenase activity|UDPacetylglucosamine dehydrogenase activity|UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase activity|uridine diphosphoacetylglucosamine dehydrogenase activity|UDP-N-acetyl-D-glucosamine:NAD+ 6-oxidoreductase activity EC:1.1.1.136|RHEA:13325|MetaCyc:1.1.1.136-RXN|KEGG_REACTION:R00421 molecular_function owl:Class
GO:0020036 biolink:NamedThing Maurer's cleft A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton. got7fsn_ti Maurers cleft cellular_component owl:Class
GO:0050828 biolink:NamedThing regulation of liquid surface tension Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid. got7fsn_ti surfactant activity|regulation of surface tension of a liquid biological_process owl:Class
GO:1901320 biolink:NamedThing negative regulation of heart induction Any process that stops, prevents or reduces the frequency, rate or extent of heart induction. got7fsn_ti down-regulation of heart induction|downregulation of heart induction|down regulation of heart induction|inhibition of heart induction bf 2012-08-28T15:48:38Z biological_process owl:Class
GO:0050329 biolink:NamedThing tetrahydroxypteridine cycloisomerase activity Catalysis of the reaction: tetrahydroxypteridine = H(+) + xanthine-8-carboxylate. got7fsn_ti tetrahydroxypteridine lyase (isomerizing) MetaCyc:TETRAHYDROXYPTERIDINE-CYCLOISOMERASE-RXN|KEGG_REACTION:R04154|EC:5.5.1.3|RHEA:18097 molecular_function owl:Class
GO:0062181 biolink:NamedThing 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity Catatlysis of the reaction: calcitriol + 2 H(+) + O2 + 2 reduced [adrenodoxin] = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized [adrenodoxin]. got7fsn_ti dph 2019-11-26T17:16:39Z RHEA:49192 molecular_function owl:Class
GO:0102459 biolink:NamedThing 8-oxo-deoxyadenine diphosphate phosphatase activity Catalysis of the reaction: 8-oxo-dADP + H2O = 8-oxo-dAMP + hydrogenphosphate + H+. got7fsn_ti MetaCyc:RXN-14005 molecular_function owl:Class
GO:0160003 biolink:NamedThing mono-ADP-D-ribose modification-dependent protein binding Binding to a protein upon mono-ADP-ribosylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require a mono-ADP-D-ribose post-translational modification: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of the ADP-D-ribose modification. It may be that the PTM causes a conformational change that allows binding of the protein to another region; this type of modification-dependent protein binding is valid for annotation to this term. rl 2021-07-12T23:36:00Z molecular_function owl:Class
GO:0034737 biolink:NamedThing ergosterol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + ergosterol = CoA + ergosterol ester. got7fsn_ti molecular_function owl:Class
GO:0102145 biolink:NamedThing (3R)-(E)-nerolidol synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O <=> (3R,6E)-nerolidol + diphosphoric acid. got7fsn_ti RHEA:27534|EC:4.2.3.49|MetaCyc:RXN-11575 molecular_function owl:Class
GO:0102773 biolink:NamedThing dihydroceramide kinase activity Catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate. got7fsn_ti MetaCyc:RXN-7799|EC:2.7.1.138 molecular_function owl:Class
GO:0009447 biolink:NamedThing putrescine catabolic process The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine. got7fsn_ti putrescine degradation|putrescine catabolism|putrescine breakdown biological_process owl:Class
GO:0045997 biolink:NamedThing negative regulation of ecdysteroid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids. got7fsn_ti down-regulation of ecdysteroid biosynthetic process|downregulation of ecdysteroid biosynthetic process|negative regulation of ecdysteroid synthesis|negative regulation of ecdysteroid anabolism|inhibition of ecdysteroid biosynthetic process|down regulation of ecdysteroid biosynthetic process|negative regulation of ecdysteroid biosynthesis|negative regulation of ecdysteroid formation biological_process owl:Class
GO:0039600 biolink:NamedThing induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process The process in which a virus increases the frequency, rate or extent of the breakdown of host nuclear-transcribed mRNAs that begins with endonucleolytic cleavage (by either a host or a viral RNAse) to generate unprotected ends. got7fsn_ti induction by virus of host nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|induction by virus of host endonucleolytic cleavage-dependent mRNA decay Some viruses utilize a host RNase to induce endonucleolytic cleavage of template mRNAs (e.g. the NSP1 protein of SARS coronavirus); for these consider instead annotating to the child term 'induction by virus of host endoribonuclease activity ; GO:0039597'. Other viral proteins act as endonucleases themselves to cleave mRNA and then rely on the host degradation machinery to clear the resulting fragments (e.g. gamma herpesvirus SOX protein); for these cases consider instead annotating to the child term 'endoribonuclease activity involved in viral induction of host mRNA catabolic process ; GO:0039594'. bf 2012-07-04T05:23:43Z biological_process owl:Class
GO:0009821 biolink:NamedThing alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). got7fsn_ti alkaloid synthesis|alkaloid formation|alkaloid anabolism|alkaloid biosynthesis UM-BBD_enzymeID:e0711 biological_process owl:Class
GO:0051788 biolink:NamedThing response to misfolded protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a misfolded protein stimulus. got7fsn_ti biological_process owl:Class
GO:0050474 biolink:NamedThing (S)-norcoclaurine synthase activity Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O. got7fsn_ti 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine; (S)-norcoclaurine-forming]|(S)-norlaudanosoline synthase activity|4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine) GO:0050475 EC:4.2.1.78|RHEA:16173|MetaCyc:S-NORLAUDANOSOLINE-SYNTHASE-RXN molecular_function owl:Class
GO:0016340 biolink:NamedThing calcium-dependent cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction. got7fsn_ti biological_process owl:Class
GO:0004150 biolink:NamedThing dihydroneopterin aldolase activity Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. got7fsn_ti 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)|2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity EC:4.1.2.25|MetaCyc:H2NEOPTERINALDOL-RXN|RHEA:10540 molecular_function owl:Class
GO:0031715 biolink:NamedThing C5L2 anaphylatoxin chemotactic receptor binding Binding to a C5L2 anaphylatoxin chemotactic receptor. got7fsn_ti C5L2 anaphylatoxin chemotactic receptor ligand molecular_function owl:Class
GO:0031714 biolink:NamedThing C5a anaphylatoxin chemotactic receptor binding Binding to a C5a anaphylatoxin chemotactic receptor. got7fsn_ti C5a anaphylatoxin chemotactic receptor ligand molecular_function owl:Class
GO:0004463 biolink:NamedThing leukotriene-A4 hydrolase activity Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4). got7fsn_ti LTA4H|LTA-4 hydrolase activity|leukotriene A4 hydrolase activity|(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity|leukotriene A(4) hydrolase activity|LTA4 hydrolase activity EC:3.3.2.6|Reactome:R-HSA-266072|KEGG_REACTION:R03057|RHEA:22324|MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN molecular_function owl:Class
GO:0102615 biolink:NamedThing ent-cassadiene-C2-hydroxylase activity Catalysis of the reaction: ent-cassa-12,15-diene + NADPH + O2 + H+ <=> 2alpha-hydroxy-ent-cassadiene + NADP + H2O. got7fsn_ti MetaCyc:RXN-15462|RHEA:55484 molecular_function owl:Class
GO:0047447 biolink:NamedThing erythro-3-hydroxyaspartate ammonia-lyase activity Catalysis of the reaction: erythro-3-hydroxy-L-aspartate = NH3 + oxaloacetic acid. got7fsn_ti erythro-3-hydroxy-Ls-aspartate ammonia-lyase (oxaloacetate-forming)|erythro-3-hydroxy-Ls-aspartate ammonia-lyase activity|erythro-3-hydroxy-L(s)-aspartate hydro-lyase (deaminating) activity|erythro-3-hydroxy-Ls-aspartate hydro-lyase (deaminating)|3-hydroxyaspartate dehydratase activity|erythro-beta-hydroxyaspartate dehydratase activity|erythro-3-hydroxyaspartate dehydratase activity MetaCyc:4.3.1.20-RXN|RHEA:19757|EC:4.3.1.20 molecular_function owl:Class
GO:0004068 biolink:NamedThing aspartate 1-decarboxylase activity Catalysis of the reaction: L-aspartate = beta-alanine + CO2. got7fsn_ti aspartate alpha-decarboxylase activity|aspartic alpha-decarboxylase|L-aspartate 1-carboxy-lyase activity|L-aspartate 1-carboxy-lyase (beta-alanine-forming)|L-aspartate alpha-decarboxylase activity EC:4.1.1.11|MetaCyc:PWY-5155|RHEA:19497|MetaCyc:ASPDECARBOX-RXN molecular_function owl:Class
GO:0016496 biolink:NamedThing substance P receptor activity Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0010474 biolink:NamedThing glucose-1-phosphate guanylyltransferase (GDP) activity Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose. got7fsn_ti GDP:glucose-1-phosphate guanyltransferase activity molecular_function owl:Class
GO:0102517 biolink:NamedThing oleate 12-hydroxylase activity Catalysis of the reaction: oleoyl-CoA + NADH + O2 + H+ = ricinoleyl-CoA + NAD + H2O. got7fsn_ti MetaCyc:RXN-14487 molecular_function owl:Class
GO:0015486 biolink:NamedThing glycoside-pentoside-hexuronide:cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+. got7fsn_ti molecular_function owl:Class
GO:0031416 biolink:NamedThing NatB complex A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p. got7fsn_ti N-terminal acetyltransferase B complex cellular_component owl:Class
GO:0097169 biolink:NamedThing AIM2 inflammasome complex An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA. got7fsn_ti pr 2011-10-03T07:36:21Z cellular_component owl:Class
GO:1990091 biolink:NamedThing sodium-dependent self proteolysis The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. got7fsn_ti sl 2013-05-06T17:30:23Z biological_process owl:Class
GO:0032232 biolink:NamedThing negative regulation of actin filament bundle assembly Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles. got7fsn_ti down-regulation of actin filament bundle formation|downregulation of actin filament bundle formation|down regulation of actin filament bundle formation|inhibition of actin filament bundle formation biological_process owl:Class
GO:1990856 biolink:NamedThing methionyl-initiator methionine tRNA binding Binding to methionine-initator methionine tRNA. got7fsn_ti An example of this is eukaryotic initiation factor 2 complex, which binds the methionyl-initiator methionine tRNA during ternary complex formation. The non-acylated tRNA is not bound. hjd 2015-09-18T16:56:59Z molecular_function owl:Class
GO:0060361 biolink:NamedThing flight Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement. got7fsn_ti biological_process owl:Class
GO:0031544 biolink:NamedThing peptidyl-proline 3-dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2. got7fsn_ti molecular_function owl:Class
GO:0051029 biolink:NamedThing rRNA transport The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0016941 biolink:NamedThing natriuretic peptide receptor activity Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0034371 biolink:NamedThing chylomicron remodeling The acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid. got7fsn_ti chylomicron remnant formation biological_process owl:Class
GO:0034370 biolink:NamedThing triglyceride-rich lipoprotein particle remodeling The acquisition, loss or modification of a protein or lipid within a triglyceride-rich lipoprotein particle, including the hydrolysis of triglyceride by lipoprotein lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride from a triglyceride-rich lipoprotein particle. got7fsn_ti triacylglycerol-rich lipoprotein particle remodeling biological_process owl:Class
GO:0102426 biolink:NamedThing myricetin-3-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: myricetin 3-O-beta-D-glucopyranoside + UDP-alpha-D-glucose <=> myricetin 3-O-gentiobioside + UDP + H+. got7fsn_ti MetaCyc:RXN-13823 molecular_function owl:Class
GO:0004643 biolink:NamedThing phosphoribosylaminoimidazolecarboxamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. got7fsn_ti AICAR formyltransferase activity|aminoimidazolecarboxamide ribonucleotide transformylase activity|5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity|AICAR transformylase activity|10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity|5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity|5-amino-4-imidazolecarboxamide ribotide transformylase activity|5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity|10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity RHEA:22192|Reactome:R-HSA-73798|EC:2.1.2.3|MetaCyc:AICARTRANSFORM-RXN molecular_function owl:Class
GO:0000706 biolink:NamedThing meiotic DNA double-strand break processing The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis. got7fsn_ti biological_process owl:Class
GO:0046931 biolink:NamedThing pore complex assembly The aggregation, arrangement and bonding together of a set of components to form a pore complex. A pore complex is a small opening in a membrane that allows the passage of liquids and/or gases. got7fsn_ti pore-forming toxin activity|pore complex biogenesis|pore formation|pore biosynthesis See also the cellular component term 'pore complex ; GO:0046930'. biological_process owl:Class
GO:0102248 biolink:NamedThing diacylglycerol transacylase activity Catalysis of the reaction: 2 a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + a 2-monoglyceride. got7fsn_ti MetaCyc:RXN-12383 molecular_function owl:Class
GO:1900970 biolink:NamedThing positive regulation of sarcinapterin metabolic process Any process that activates or increases the frequency, rate or extent of sarcinapterin metabolic process. got7fsn_ti activation of sarcinapterin metabolic process|upregulation of sarcinapterin metabolism|upregulation of sarcinapterin metabolic process|up regulation of sarcinapterin metabolism|up regulation of sarcinapterin metabolic process|up-regulation of sarcinapterin metabolism|activation of sarcinapterin metabolism|up-regulation of sarcinapterin metabolic process|positive regulation of sarcinapterin metabolism tt 2012-06-14T03:58:43Z biological_process owl:Class
GO:0045864 biolink:NamedThing positive regulation of pteridine metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pteridine. got7fsn_ti upregulation of pteridine metabolic process|up regulation of pteridine metabolic process|stimulation of pteridine metabolic process|activation of pteridine metabolic process|positive regulation of pteridine metabolism|up-regulation of pteridine metabolic process biological_process owl:Class
GO:0018577 biolink:NamedThing catechol 2,3-dioxygenase activity Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde. got7fsn_ti catechol oxygenase|2,3-pyrocatechase activity|pyrocatechol 2,3-dioxygenase|catechol 2,3-oxygenase|cato2ase activity|metapyrocatechase activity|catechol:oxygen 2,3-oxidoreductase (decyclizing) MetaCyc:CATECHOL-23-DIOXYGENASE-RXN|UM-BBD_enzymeID:e0156|RHEA:17337|EC:1.13.11.2 molecular_function owl:Class
GO:0034377 biolink:NamedThing plasma lipoprotein particle assembly The non-covalent aggregation and arrangement of proteins and lipids to form a plasma lipoprotein particle. got7fsn_ti biological_process owl:Class
GO:0031738 biolink:NamedThing XCR1 chemokine receptor binding Binding to a XCR1 chemokine receptor. got7fsn_ti XCR1 chemokine receptor ligand|lymphotactin receptor binding molecular_function owl:Class
GO:0061141 biolink:NamedThing lung ciliated cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells. got7fsn_ti dph 2010-05-25T09:31:14Z biological_process owl:Class
GO:0043990 biolink:NamedThing histone H2A-S1 phosphorylation The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone. got7fsn_ti histone H2AS1 phosphorylation|histone H2A phosphorylation at S1 biological_process owl:Class
GO:0018213 biolink:NamedThing peptidyl-valine modification The modification of peptidyl-valine. got7fsn_ti biological_process owl:Class
GO:0060030 biolink:NamedThing dorsal convergence The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement. got7fsn_ti biological_process owl:Class
GO:0102332 biolink:NamedThing fatty-acyl-[acp] elongase/decarboxylase activity Catalysis of the reaction: malonyl-CoA + H+ + a long-chain acyl-[acp] + a reduced electron acceptor = 2 carbon dioxide + coenzyme A + a terminal olefin + a holo-[acyl-carrier protein] + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-13260 molecular_function owl:Class
GO:0010370 biolink:NamedThing perinucleolar chromocenter A chromocenter adjacent to the nucleolus. got7fsn_ti cellular_component owl:Class
GO:0010369 biolink:NamedThing chromocenter A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure. got7fsn_ti cellular_component owl:Class
GO:0050584 biolink:NamedThing linoleate 11-lipoxygenase activity Catalysis of the reaction: linoleate + O(2) = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate. got7fsn_ti linoleate:oxygen 11S-oxidoreductase activity|manganese lipoxygenase activity|linoleate dioxygenase activity EC:1.13.11.45|MetaCyc:1.13.11.45-RXN|RHEA:18993|KEGG_REACTION:R05718 molecular_function owl:Class
GO:0021520 biolink:NamedThing spinal cord motor neuron cell fate specification The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway. got7fsn_ti biological_process owl:Class
GO:0016330 biolink:NamedThing second mitotic wave involved in compound eye morphogenesis A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia. got7fsn_ti second mitotic wave during compound eye morphogenesis biological_process owl:Class
GO:0031747 biolink:NamedThing type 2 cysteinyl leukotriene receptor binding Binding to a type 2 cysteinyl leukotriene receptor. got7fsn_ti type 2 cysteinyl leukotriene receptor ligand molecular_function owl:Class
GO:0002487 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway biological_process owl:Class
GO:0010283 biolink:NamedThing pinoresinol reductase activity Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+. got7fsn_ti MetaCyc:RXN-8683|MetaCyc:RXN-8678 molecular_function owl:Class
GO:0103085 biolink:NamedThing 2-(5'-methylthio)pentylmalate synthase activity Catalysis of the reaction: 2-oxo-7-methylthioheptanoate + acetyl-CoA + H2O <=> H+ + 2-(5'-methylthio)pentylmalate + coenzyme A. got7fsn_ti MetaCyc:RXNQT-4169 molecular_function owl:Class
GO:0006625 biolink:NamedThing protein targeting to peroxisome The process of directing proteins towards the peroxisome, usually using signals contained within the protein. got7fsn_ti protein-peroxisome targeting biological_process owl:Class
GO:0106317 biolink:NamedThing methane monooxygenase NADH activity Catalysis of the reaction: methane + NADH + H+ + O2 = methanol + NAD+ + H2O. got7fsn_ti hjd 2020-09-23T15:12:25Z RHEA:13637|EC:1.14.13.25 molecular_function owl:Class
GO:0052830 biolink:NamedThing inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate. got7fsn_ti ai 2011-11-29T10:56:59Z Reactome:R-HSA-1855171 molecular_function owl:Class
GO:0036429 biolink:NamedThing adenosylcobinamide kinase (ATP-specific) activity Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+. got7fsn_ti bf 2013-09-16T14:05:56Z RHEA:15769|KEGG_REACTION:R05221|MetaCyc:COBINAMIDEKIN-RXN molecular_function owl:Class
GO:0036420 biolink:NamedThing extrinsic component of mycolate outer membrane The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to mycolate outer membrane|extrinsic to mycomembrane|extrinsic to MOM bf 2013-09-05T20:22:02Z cellular_component owl:Class
GO:0006718 biolink:NamedThing juvenile hormone biosynthetic process The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis. got7fsn_ti juvenile hormone synthesis|juvenile hormone biosynthesis|juvenile hormone anabolism|juvenile hormone formation biological_process owl:Class
GO:0045840 biolink:NamedThing positive regulation of mitotic nuclear division Any process that activates or increases the frequency, rate or extent of mitosis. got7fsn_ti up-regulation of mitosis|upregulation of mitosis|mitogenic activity|up regulation of mitosis|stimulation of mitosis|positive regulation of mitosis|activation of mitosis biological_process owl:Class
GO:0005004 biolink:NamedThing GPI-linked ephrin receptor activity Combining with a GPI-anchored ephrin to initiate a change in cell activity. got7fsn_ti GPI-linked Eph receptor activity molecular_function owl:Class
GO:0005003 biolink:NamedThing ephrin receptor activity Combining with an ephrin to initiate a change in cell activity. got7fsn_ti Eph receptor activity molecular_function owl:Class
GO:0070767 biolink:NamedThing BRCA1-Rad51 complex A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity. got7fsn_ti mah 2009-06-29T05:04:21Z cellular_component owl:Class
GO:0004746 biolink:NamedThing riboflavin synthase activity Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin. got7fsn_ti 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity|riboflavin synthetase activity|light riboflavin synthase|riboflavine synthetase activity|heavy riboflavin synthase|riboflavine synthase activity|vitamin B2 synthase activity|lumazine synthase activity RHEA:20772|EC:2.5.1.9|KEGG_REACTION:R00066|MetaCyc:RIBOFLAVIN-SYN-RXN molecular_function owl:Class
GO:0071727 biolink:NamedThing cellular response to triacyl bacterial lipopeptide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triacylated bacterial lipopeptide stimulus. got7fsn_ti cellular response to triacylated bacterial lipoprotein Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. mah 2010-03-17T02:17:49Z biological_process owl:Class
GO:0120285 biolink:NamedThing tyrosine sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of tyrosine. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20181 krc 2020-11-18T01:19:42Z molecular_function owl:Class
GO:0072545 biolink:NamedThing tyrosine binding Binding to 2-amino-3-(4-hydroxyphenyl)propanoic acid. got7fsn_ti Tyr binding mah 2011-01-19T05:43:55Z molecular_function owl:Class
GO:2000292 biolink:NamedThing regulation of defecation Any process that modulates the frequency, rate or extent of defecation. got7fsn_ti bf 2010-12-21T09:23:08Z biological_process owl:Class
GO:0004671 biolink:NamedThing protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. got7fsn_ti prenylcysteine methyltransferase activity|farnesyl-protein carboxymethyltransferase activity|prenylated protein methyltransferase activity|prenylcysteine carboxylmethyltransferase activity|farnesyl cysteine C-terminal methyltransferase activity|prenylcysteine carboxymethyltransferase activity|farnesylated protein C-terminal O-methyltransferase activity|isoprenylated protein methyltransferase activity|prenylcysteine carboxyl methyltransferase activity|protein-S-isoprenylcysteine O-methyltransferase activity|S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity|protein S-farnesylcysteine C-terminal methyltransferase activity|protein C-terminal farnesylcysteine O-methyltransferase activity|prenylated protein carboxyl methyltransferase activity|isoprenylcysteine carboxylmethyltransferase activity|S-farnesylcysteine methyltransferase activity GO:0018225 EC:2.1.1.100|Reactome:R-HSA-6788650|MetaCyc:2.1.1.100-RXN|RHEA:21672|KEGG_REACTION:R04496|Reactome:R-HSA-9647977 molecular_function owl:Class
GO:0004419 biolink:NamedThing hydroxymethylglutaryl-CoA lyase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA. got7fsn_ti 3-hydroxy-3-methylglutaryl-CoA lyase activity|hydroxymethylglutaryl coenzyme A-cleaving enzyme|HMG-CoA lyase activity|hydroxymethylglutaryl coenzyme A lyase activity|3-hydroxy-3-methylglutarate-CoA lyase activity|3-hydroxy-3-methylglutaryl coenzyme A lyase activity|(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)|3-hydroxy-3-methylglutaryl CoA cleaving enzyme|(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity EC:4.1.3.4|MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN|Reactome:R-HSA-6788597|Reactome:R-HSA-74180|KEGG_REACTION:R01360|RHEA:24404 molecular_function owl:Class
GO:0102114 biolink:NamedThing caprate dehydroxylase activity Catalysis of the reaction: decanoate + NADPH + O2 + H+ <=> 10-hydroxycaprate + NADP + H2O. got7fsn_ti MetaCyc:RXN-11325 molecular_function owl:Class
GO:0106148 biolink:NamedThing 4-hydroxyindole-3- carbonyl nitrile biosynthesis The chemical reactions and pathways resulting in the formation of 4-hydroxyindole-3- carbonyl nitrile (4-OH-ICN), a cyanogenic glucoside. got7fsn_ti hjd 2018-09-10T19:42:16Z biological_process owl:Class
GO:0051360 biolink:NamedThing peptide cross-linking via L-asparagine 5-imidazolinone glycine The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. got7fsn_ti biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via L-asparagine 5-imidazolinone glycine See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. RESID:AA0380 biological_process owl:Class
GO:0018902 biolink:NamedThing 1,3-dichloro-2-propanol metabolic process The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers. got7fsn_ti 1,3-dichloro-2-propanol metabolism|DCP metabolic process|DCP metabolism UM-BBD_pathwayID:dcp biological_process owl:Class
GO:0044102 biolink:NamedThing purine deoxyribosyltransferase activity Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor. got7fsn_ti purine 2'-deoxyribosyltransferase activity|PTD jl 2009-07-09T03:40:15Z molecular_function owl:Class
GO:0052900 biolink:NamedThing spermine oxidase (propane-1,3-diamine-forming) activity Catalysis of the reaction: H(2)O + O(2) + spermine = 1,3-diaminopropane + H(2)O(2) + N-(3-aminopropyl)-4-aminobutanal. got7fsn_ti polyamine oxidase (propane-1,3-diamine-forming) activity MetaCyc:RXN-6421|EC:1.5.3.14|RHEA:25824 molecular_function owl:Class
GO:0070185 biolink:NamedThing mitochondrial valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA in a mitochondrion, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0021752 biolink:NamedThing inferior salivary nucleus development The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0051989 biolink:NamedThing coproporphyrinogen dehydrogenase activity Catalysis of the reaction: coproporphyrinogen III + 2 S-adenosyl-L-methionine = protoporphyrinogen IX + 2 CO2 + 2 L-methionine + 2 5'-deoxyadenosine. got7fsn_ti coproporphyrinogen III oxidase activity|HemN|coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)|oxygen-independent coproporphyrinogen-III oxidase activity|radical SAM enzyme activity EC:1.3.98.3|MetaCyc:HEMN-RXN|RHEA:15425 molecular_function owl:Class
GO:0004167 biolink:NamedThing dopachrome isomerase activity Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. got7fsn_ti dopachrome keto-enol isomerase activity|L-dopachrome keto-enol isomerase activity|TRP2|TRP activity|dopachrome oxidoreductase activity|L-dopachrome-methyl ester tautomerase activity|dopachrome delta7,Delta2-isomerase activity|L-dopachrome isomerase activity|dopachrome rearranging enzyme activity|dopachrome conversion activity|TRP-2|tryosinase-related protein-2|TRP-1|tyrosinase-related protein 2 activity|DCF activity|dopachrome Delta(7),Delta(2)-isomerase activity|dopachrome-rearranging enzyme|DCT activity|dopachrome conversion factor activity|dopachrome delta-isomerase activity|dopachrome tautomerase activity GO:0048059 RHEA:13041|MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN|KEGG_REACTION:R03673|EC:5.3.3.12 molecular_function owl:Class
GO:0036061 biolink:NamedThing muscle cell chemotaxis toward tendon cell The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells. got7fsn_ti muscle cell chemotaxis towards tendon cell|muscle cell attraction bf 2011-12-14T11:13:40Z biological_process owl:Class
GO:0097673 biolink:NamedThing SCF-Ucc1 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is YLR224W in S. cerevisiae. got7fsn_ti SCF-YLR224W ubiquitin ligase complex pr 2014-10-06T10:30:31Z cellular_component owl:Class
GO:0050625 biolink:NamedThing 2-hydroxy-1,4-benzoquinone reductase activity Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+). got7fsn_ti 2-hydroxy-1,4-benzoquinone:NADH oxidoreductase activity|NADH:2-hydroxy-1,4-benzoquinone oxidoreductase activity|1,2,4-trihydroxybenzene:NAD oxidoreductase activity|hydroxybenzoquinone reductase activity|1,2,4-trihydroxybenzene:NAD+ oxidoreductase activity GO:0018540 KEGG_REACTION:R05399|MetaCyc:1.6.5.7-RXN|EC:1.6.5.7|UM-BBD_reactionID:r0667|RHEA:12428 molecular_function owl:Class
GO:0140560 biolink:NamedThing xylosyl alpha-1,3-xylosyltransferase activity Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16869 pg 2020-11-25T13:45:18Z RHEA:22820|EC:2.4.2.62 molecular_function owl:Class
GO:0047156 biolink:NamedThing acetoin-ribose-5-phosphate transaldolase activity Catalysis of the reaction: D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde. got7fsn_ti 1-deoxy-D-altro-heptulose-7-phosphate synthetase activity|3-hydroxybutan-3-one:D-ribose-5-phosphate aldehydetransferase activity|1-deoxy-D-altro-heptulose-7-phosphate synthase activity|3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase activity MetaCyc:2.2.1.4-RXN|RHEA:21504|KEGG_REACTION:R02345|EC:2.2.1.4 molecular_function owl:Class
GO:1990227 biolink:NamedThing paranodal junction maintenance The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath. got7fsn_ti axoglial septate junction maintenance|paranodal septate maintenance|paranodal axoglial junction maintenance pr 2013-11-07T20:01:46Z biological_process owl:Class
GO:0045217 biolink:NamedThing cell-cell junction maintenance The maintenance of junctions between cells. got7fsn_ti intercellular junction maintenance biological_process owl:Class
GO:0071259 biolink:NamedThing cellular response to magnetism Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnetic stimulus. got7fsn_ti cellular response to magnetic stimulus mah 2009-12-04T03:54:53Z biological_process owl:Class
GO:0062209 biolink:NamedThing spatial regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination Any process that modulates the distribution of sites along the chromosome where meiotic DNA double-strand break formation takes place as part of reciprocal meiotic recombination. got7fsn_ti regulation of spatial distribution of meiotic DSB formation involved in reciprocal meiotic recombination|regulation of spatial distribution of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination|DSB interference|crossover interference dph 2020-02-03T19:19:29Z biological_process owl:Class
GO:0006568 biolink:NamedThing tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. got7fsn_ti tryptophan metabolism Wikipedia:Tryptophan biological_process owl:Class
GO:0102048 biolink:NamedThing indole-3-acetyl-isoleucine synthetase activity Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) <=> H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10430 molecular_function owl:Class
GO:0004102 biolink:NamedThing choline O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA. got7fsn_ti choline acetylase activity|acetyl-CoA:choline O-acetyltransferase activity|choline acetyltransferase activity|CHOACTase activity EC:2.3.1.6|Reactome:R-HSA-264622|KEGG_REACTION:R01023|RHEA:18821|MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:0018680 biolink:NamedThing deethylatrazine monooxygenase activity Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine. got7fsn_ti EC:1.14.15.-|UM-BBD_reactionID:r0128 molecular_function owl:Class
GO:0072548 biolink:NamedThing dicoumaroyl monocaffeoyl spermidine meta-hydroxylase activity Catalysis of the reaction: dicoumaroyl monocaffeoyl spermidine + NADPH + O2 = monocoumaroyl dicaffeoyl spermidine + NADP+ + H2O. got7fsn_ti mah 2011-01-25T02:57:22Z molecular_function owl:Class
GO:0150195 biolink:NamedThing transport across blood-cerebrospinal fluid barrier The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-cerebrospinal fluid barrier. got7fsn_ti transport across BCSFB|transport across blood/cerebrospinal fluid barrier|transport across blood/CSF barrier|transport across blood-CSF barrier bc 2020-03-26T14:43:04Z biological_process owl:Class
GO:0060003 biolink:NamedThing copper ion export The directed movement of copper ions out of a cell or organelle. got7fsn_ti copper export biological_process owl:Class
GO:0035434 biolink:NamedThing copper ion transmembrane transport The directed movement of copper cation across a membrane. got7fsn_ti copper ion membrane transport|copper cation transmembrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-08T11:03:23Z GO:1901473 biological_process owl:Class
GO:0033709 biolink:NamedThing D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity Catalysis of the reaction: D-arabinitol + NADP+ = D-ribulose + NADPH + H+. got7fsn_ti NADP+-dependent D-arabinitol dehydrogenase activity|ARD1p|D-arabinitol dehydrogenase 1 activity|D-arabinitol:NADP+ dehydrogenase activity RHEA:11868|KEGG_REACTION:R07144|MetaCyc:RXN-7972 molecular_function owl:Class
GO:0016913 biolink:NamedThing follicle-stimulating hormone activity The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis. got7fsn_ti follicle stimulating hormone activity|FSH activity|follitropin activity molecular_function owl:Class
GO:0009603 biolink:NamedThing detection of symbiotic fungus The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal. got7fsn_ti perception of symbiotic fungi|detection of symbiotic fungi|perception of symbiotic fungus biological_process owl:Class
GO:0009706 biolink:NamedThing chloroplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. got7fsn_ti chloroplast inner envelope cellular_component owl:Class
GO:0061117 biolink:NamedThing negative regulation of heart growth Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart. got7fsn_ti dph 2010-05-17T07:31:28Z biological_process owl:Class
GO:0034940 biolink:NamedThing 5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3. got7fsn_ti UM-BBD_reactionID:r0984 molecular_function owl:Class
GO:0102171 biolink:NamedThing DMNT synthase activity Catalysis of the reaction: H+ + (3S,6E)-nerolidol + NADPH + O2 <=> (E)-4,8-dimethyl-1,3,7-nonatriene + buten-2-one + NADP + 2 H2O. got7fsn_ti RHEA:55424|MetaCyc:RXN-11911 molecular_function owl:Class
GO:0005094 biolink:NamedThing Rho GDP-dissociation inhibitor activity Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. got7fsn_ti molecular_function owl:Class
GO:0070407 biolink:NamedThing oxidation-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the oxidation of one or more amino acid residues in the protein. got7fsn_ti oxidized protein catabolic process|oxidation-dependent protein breakdown|oxidation-dependent proteolysis|oxidation-dependent protein catabolism|oxidation-dependent protein degradation biological_process owl:Class
GO:0043246 biolink:NamedThing megasome Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex. got7fsn_ti cellular_component owl:Class
GO:0034864 biolink:NamedThing 2,4,4-trimethylpentanal dehydrogenase activity Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1275 molecular_function owl:Class
GO:0061249 biolink:NamedThing mesonephric glomerular capillary formation The process that gives rise to a mesonephric glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti dph 2010-08-30T01:17:08Z biological_process owl:Class
GO:0050637 biolink:NamedThing lovastatin nonaketide synthase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+). got7fsn_ti acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) RHEA:18565|KEGG_REACTION:R07251|MetaCyc:2.3.1.161-RXN|EC:2.3.1.161 molecular_function owl:Class
GO:0004408 biolink:NamedThing holocytochrome-c synthase activity Catalysis of the reaction: holocytochrome c = apocytochrome c + heme. got7fsn_ti cytochrome c heme-lyase activity|holocytochrome-c apocytochrome-c-lyase activity|holocytochrome c synthetase activity|cytochrome c synthase activity|holocytochrome-c apocytochrome-c-lyase (heme-forming) RHEA:22648|EC:4.4.1.17|MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN molecular_function owl:Class
GO:0070791 biolink:NamedThing cleistothecium development The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. got7fsn_ti mah 2009-07-08T02:52:32Z biological_process owl:Class
GO:0000909 biolink:NamedThing sporocarp development involved in sexual reproduction The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi. got7fsn_ti perfect stage fruiting body development|fruiting body formation involved in sexual reproduction|ascus development|fruiting body development involved in sexual reproduction biological_process owl:Class
GO:0015989 biolink:NamedThing light-driven proton transport The transport of protons against an electrochemical gradient, using energy from light. got7fsn_ti biological_process owl:Class
GO:0001208 biolink:NamedThing histone H2A-H2B dimer displacement The removal of a H2A-H2B histone dimer from a nucleosome within chromatin. got7fsn_ti krc 2012-03-27T11:03:40Z biological_process owl:Class
GO:0005616 biolink:NamedThing larval serum protein complex A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins. got7fsn_ti cellular_component owl:Class
GO:0021870 biolink:NamedThing Cajal-Retzius cell differentiation The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene. got7fsn_ti biological_process owl:Class
GO:1990641 biolink:NamedThing response to iron ion starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion. got7fsn_ti sl 2015-02-11T18:43:28Z biological_process owl:Class
GO:0052081 biolink:NamedThing modulation by symbiont of defense-related host salicylic acid-mediated signal transduction pathway Any process in which an organism modulates the frequency, rate or extent of host salicylic acid-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation of defense-related host SA-mediated signal transduction pathway by organism|modulation by organism of defense-related salicylic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction GO:0052445 biological_process owl:Class
GO:0002175 biolink:NamedThing protein localization to paranode region of axon A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon. got7fsn_ti protein localisation to paranode region of axon hjd 2010-11-15T10:28:20Z biological_process owl:Class
GO:0044349 biolink:NamedThing DNA excision The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised. got7fsn_ti jl 2011-08-03T10:56:37Z biological_process owl:Class
GO:0018496 biolink:NamedThing 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA. got7fsn_ti UM-BBD_reactionID:r0205 molecular_function owl:Class
GO:0051675 biolink:NamedThing isopullulanase activity Catalysis of the hydrolysis of pullulan to isopanose (6-alpha-maltosylglucose). got7fsn_ti pullulan 4-glucanohydrolase (isopanose-forming) activity MetaCyc:3.2.1.57-RXN|EC:3.2.1.57 molecular_function owl:Class
GO:0050223 biolink:NamedThing protocatechuate decarboxylase activity Catalysis of the reaction: 3,4-dihydroxybenzoate + H(+) = catechol + CO(2). got7fsn_ti 3,4-dihydroxybenzoate decarboxylase activity|protocatechuate carboxy-lyase activity|3,4-dihydrobenzoate decarboxylase activity|3,4-dihydroxybenzoate carboxy-lyase (catechol-forming) MetaCyc:PROTOCATECHUATE-DECARBOXYLASE-RXN|RHEA:22416|EC:4.1.1.63|KEGG_REACTION:R00822 molecular_function owl:Class
GO:0045730 biolink:NamedThing respiratory burst A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. got7fsn_ti metabolic burst|oxidative burst Wikipedia:Respiratory_burst biological_process owl:Class
GO:0036239 biolink:NamedThing taxoid 7beta-hydroxylase activity Catalysis of the reaction: taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O. got7fsn_ti bf 2012-05-22T02:13:21Z MetaCyc:RXN-12885|EC:1.14.13.147|KEGG_REACTION:R09868|RHEA:31975 molecular_function owl:Class
GO:0050487 biolink:NamedThing sulfoacetaldehyde acetyltransferase activity Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde. got7fsn_ti acetyl-phosphate:sulfite S-acetyltransferase (acyl-phosphate hydrolysing, 2-oxoethyl-forming)|sulphoacetaldehyde acetyltransferase activity Note that the enzyme sulfoacetaldehyde acetyltransferase also has sulfoacetaldehyde lyase activity (GO:0050312). RHEA:24204|MetaCyc:RXN-2364|KEGG_REACTION:R05651|EC:2.3.3.15 molecular_function owl:Class
GO:0150016 biolink:NamedThing basal distal dendrite Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is farthest away from the neuronal cell body (the soma). got7fsn_ti bc 2017-12-21T12:11:47Z cellular_component owl:Class
GO:1900732 biolink:NamedThing regulation of polyketide biosynthetic process Any process that modulates the frequency, rate or extent of polyketide biosynthetic process. got7fsn_ti regulation of polyketide formation|regulation of polyketide biosynthesis|regulation of polyketide synthesis|regulation of polyketide anabolism di 2012-05-26T01:29:40Z biological_process owl:Class
GO:0010566 biolink:NamedThing regulation of ketone biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells. got7fsn_ti biological_process owl:Class
GO:0001125 biolink:NamedThing transcription termination from bacterial-type RNA polymerase promoter The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed. got7fsn_ti krc 2010-12-06T03:47:43Z biological_process owl:Class
GO:0047218 biolink:NamedThing hydroxycinnamate 4-beta-glucosyltransferase activity Catalysis of the reaction: 4-coumarate + UDP-D-glucose = 4-O-beta-D-glucosyl-4-hydroxycinnamate + UDP. got7fsn_ti UDP-glucose-hydroxycinnamate glucosyltransferase activity|UDPglucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-hydroxycinnamate glucosyltransferase activity|UDP-glucose:trans-4-hydroxycinnamate 4-O-beta-D-glucosyltransferase activity|hydroxycinnamoyl glucosyltransferase activity RHEA:21636|MetaCyc:2.4.1.126-RXN|EC:2.4.1.126 molecular_function owl:Class
GO:0036165 biolink:NamedThing invasive growth in response to heat The growth of colonies in filamentous chains of cells as a result of an increase in temperature. got7fsn_ti invasive growth in response to temperature stimulus|invasive growth in response to high temperature|invasive growth in response to elevated temperature bf 2012-03-27T11:23:03Z biological_process owl:Class
GO:0009773 biolink:NamedThing photosynthetic electron transport in photosystem I A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP. got7fsn_ti biological_process owl:Class
GO:0140441 biolink:NamedThing protein-cysteine S-arachidonoyltransferase activity Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl-[protein] = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-[protein]. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18882 pg 2020-03-11T09:56:24Z RHEA:59748 molecular_function owl:Class
GO:0031716 biolink:NamedThing calcitonin receptor binding Binding to a calcitonin receptor. got7fsn_ti calcitonin receptor ligand molecular_function owl:Class
GO:0090396 biolink:NamedThing leaf papilla A plant cell papilla that is part of a leaf papilla cell. got7fsn_ti Part of leaf papilla cell (PO:0025167). tb 2010-12-15T03:26:20Z cellular_component owl:Class
GO:0102779 biolink:NamedThing cannabidiolate synthase activity Catalysis of the reaction: cannabigerolate + O2 <=> cannabidiolate + hydrogen peroxide. got7fsn_ti EC:1.21.3.8|RHEA:34411|MetaCyc:RXN-7855 molecular_function owl:Class
GO:0102977 biolink:NamedThing nitrilotriacetate monooxygenase activity (FMN-dependent) Catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN. got7fsn_ti RHEA:31359|MetaCyc:RXN-9508|EC:1.14.14.10 molecular_function owl:Class
GO:0050649 biolink:NamedThing testosterone 6-beta-hydroxylase activity Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O. got7fsn_ti testosterone 6b-hydroxylase activity molecular_function owl:Class
GO:0052733 biolink:NamedThing quinate 3-dehydrogenase (NADP+) activity Catalysis of the reaction: quinate + NADP+ = 3-dehydroquinate + NADPH + H+. got7fsn_ti quinate:NADP 3-oxidoreductase activity|quinate:NADP(+) 3-oxidoreductase activity|quinic dehydrogenase activity ai 2011-08-16T04:23:47Z EC:1.1.1.282|KEGG_REACTION:R06846|RHEA:18425 molecular_function owl:Class
GO:0072760 biolink:NamedThing cellular response to GW 7647 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus. got7fsn_ti mah 2012-11-09T11:46:28Z biological_process owl:Class
GO:0018611 biolink:NamedThing toluate dioxygenase activity Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate. got7fsn_ti UM-BBD_enzymeID:e0190|EC:1.14.12.- molecular_function owl:Class
GO:0106008 biolink:NamedThing 2-oxoglutaramate amidase activity Catalysis of the reaction: 2-oxoglutaramate + H(2)O = 2-oxoglutarate + NH(3). got7fsn_ti hjd 2017-04-25T14:10:02Z RHEA:32963|EC:3.5.1.111 molecular_function owl:Class
GO:0000484 biolink:NamedThing cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0032544 biolink:NamedThing plastid translation The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. got7fsn_ti plastid protein anabolism|plastid protein synthesis|plastid protein translation|plastid protein biosynthesis|plastid protein formation biological_process owl:Class
GO:0042437 biolink:NamedThing indoleacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants. got7fsn_ti IAA catabolic process|indoleacetic acid catabolism|indole acetic acid catabolism|indole acetic acid catabolic process|indoleacetic acid breakdown|indoleacetic acid degradation biological_process owl:Class
GO:0045230 biolink:NamedThing capsule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi. got7fsn_ti capsule organisation|capsule organization and biogenesis biological_process owl:Class
GO:0019867 biolink:NamedThing outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. got7fsn_ti cellular_component owl:Class
GO:0061115 biolink:NamedThing lung proximal/distal axis specification The establishment, maintenance and elaboration of the proximal/distal axis of the lung. The proximal/distal axis of the lung is defined by a line that runs from the trachea to the alveoli. got7fsn_ti dph 2010-05-10T12:30:40Z biological_process owl:Class
GO:0140111 biolink:NamedThing [choline trimethylamine-lyase]-activating enzyme activity Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM). got7fsn_ti https://github.com/geneontology/go-ontology/issues/14190 pg 2017-10-20T13:57:38Z MetaCyc:RXN-16470 molecular_function owl:Class
GO:0035699 biolink:NamedThing T-helper 17 cell extravasation The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue. got7fsn_ti bf 2011-02-28T03:13:27Z biological_process owl:Class
GO:0052674 biolink:NamedThing ent-pimara-9(11),15-diene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate. got7fsn_ti ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-9(11),15-diene-forming] activity|PMD synthase activity MetaCyc:RXN-9299|RHEA:25544|EC:4.2.3.31 molecular_function owl:Class
GO:0061137 biolink:NamedThing bud dilation The process in which a branch bud increases radially. A branch bud is the initial area of outgrowth in the formation of a new branch. got7fsn_ti dph 2010-05-20T07:54:42Z biological_process owl:Class
GO:0050255 biolink:NamedThing ribitol 2-dehydrogenase activity Catalysis of the reaction: D-ribitol + NAD(+) = D-ribulose + H(+) + NADH. got7fsn_ti ribitol:NAD+ 2-oxidoreductase activity|ribitol dehydrogenase D (mutant enzyme with different properties)|adonitol dehydrogenase activity|ribitol dehydrogenase B (mutant enzyme with different properties)|ribitol dehydrogenase A (wild type) EC:1.1.1.56|RHEA:20053|MetaCyc:RIBITOL-2-DEHYDROGENASE-RXN|KEGG_REACTION:R01895 molecular_function owl:Class
GO:0039679 biolink:NamedThing viral occlusion body A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host. got7fsn_ti bf 2013-09-26T14:17:10Z VZ:1949 cellular_component owl:Class
GO:0140220 biolink:NamedThing pathogen-containing vacuole A membrane-bound intracellular compartment that is formed upon internalization of a pathogen into a host cell, and in which the pathogen resides. got7fsn_ti pathogen-containing compartment|pathogen inclusion https://github.com/geneontology/go-ontology/issues/15580 pg 2018-04-20T06:02:14Z cellular_component owl:Class
GO:0051736 biolink:NamedThing polyribonucleotide 5'-hydroxyl-kinase activity Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA. got7fsn_ti ATP-dependent RNA 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide kinase activity|ATP-dependent RNA kinase activity|ATP-dependent polynucleotide 5'-hydroxyl-kinase activity|ATP:5'-dephosphopolyribonucleotide 5'-phosphotransferase activity molecular_function owl:Class
GO:0061099 biolink:NamedThing negative regulation of protein tyrosine kinase activity Any process that decreases the rate, frequency, or extent of protein tyrosine kinase activity. got7fsn_ti dph 2010-04-26T02:34:53Z biological_process owl:Class
GO:0050732 biolink:NamedThing negative regulation of peptidyl-tyrosine phosphorylation Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. got7fsn_ti downregulation of peptidyl-tyrosine phosphorylation|down regulation of peptidyl-tyrosine phosphorylation|inhibition of peptidyl-tyrosine phosphorylation|down-regulation of peptidyl-tyrosine phosphorylation biological_process owl:Class
GO:0032497 biolink:NamedThing detection of lipopolysaccharide The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. got7fsn_ti detection of LPS biological_process owl:Class
GO:0050378 biolink:NamedThing UDP-glucuronate 4-epimerase activity Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate. got7fsn_ti UDP glucuronic epimerase activity|UDP-D-galacturonic acid 4-epimerase activity|UDP-galacturonate 4-epimerase activity|uridine diphospho-D-galacturonic acid|uridine diphosphoglucuronic epimerase activity|uridine diphosphoglucuronate epimerase activity|UDPglucuronate 4-epimerase activity MetaCyc:UDP-GLUCURONATE-4-EPIMERASE-RXN|EC:5.1.3.6|KEGG_REACTION:R01385|MetaCyc:PWY-4861|RHEA:11404 molecular_function owl:Class
GO:0042912 biolink:NamedThing colicin transmembrane transporter activity Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1. got7fsn_ti molecular_function owl:Class
GO:0035206 biolink:NamedThing regulation of hemocyte proliferation Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster. got7fsn_ti regulation of arthropod blood cell proliferation biological_process owl:Class
GO:0034926 biolink:NamedThing pyrene-4,5-epoxide hydrolase activity Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene. got7fsn_ti UM-BBD_reactionID:r0942 molecular_function owl:Class
GO:0006522 biolink:NamedThing alanine metabolic process The chemical reactions and pathways involving alanine, 2-aminopropanoic acid. got7fsn_ti alanine metabolism biological_process owl:Class
GO:0080130 biolink:NamedThing L-phenylalanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-phenylalanine + 2-oxoglutarate = phenylpyruvate + L-glutamate. got7fsn_ti L-phenylalanine:alpha-ketoglutarate aminotransferase activity This reaction falls within the larger set of reactions associated with EC:2.6.1.57 and several other EC numbers (See BRENDA:http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.57). dhl 2009-04-29T03:42:47Z EC:2.6.1.57|MetaCyc:PHEAMINOTRANS-RXN|MetaCyc:RXN-10814|RHEA:25152|KEGG_REACTION:R00694 molecular_function owl:Class
GO:0052728 biolink:NamedThing capsorubin synthase activity Catalysis of the reaction: violaxanthin = capsorubin. got7fsn_ti violaxanthin-capsorubin isomerase (ketone-forming) activity|ketoxanthophyll synthase activity|CCS|capsanthin-capsorubin synthase activity ai 2011-08-16T03:09:26Z RHEA:21752|EC:5.3.99.8|MetaCyc:RXN-7946 molecular_function owl:Class
GO:0106350 biolink:NamedThing octaprenyl pyrophosphate synthase activity Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate. got7fsn_ti hjd 2021-01-12T15:30:15Z RHEA:27798|EC:2.5.1.90 molecular_function owl:Class
GO:0017183 biolink:NamedThing peptidyl-diphthamide biosynthetic process from peptidyl-histidine The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria. got7fsn_ti peptidyl-diphthamide synthesis from peptidyl-histidine|peptidyl-diphthamide formation from peptidyl-histidine|peptidyl-diphthamide anabolism from peptidyl-histidine RESID:AA0040 biological_process owl:Class
GO:0008948 biolink:NamedThing oxaloacetate decarboxylase activity Catalysis of the reaction: oxaloacetate = pyruvate + CO2. got7fsn_ti oxaloacetate beta-decarboxylase activity|oxaloacetate carboxy-lyase activity|oxalate beta-decarboxylase activity|oxaloacetate carboxy-lyase (pyruvate-forming)|oxalacetic acid decarboxylase activity EC:1.1.1.40|KEGG_REACTION:R00217|EC:1.1.1.38|Reactome:R-HSA-9012016|RHEA:15641|EC:4.1.1.112|MetaCyc:OXALODECARB-RXN molecular_function owl:Class
GO:0097655 biolink:NamedThing serpin family protein binding Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors. got7fsn_ti SERPIN family protein binding pr 2014-09-24T16:19:31Z molecular_function owl:Class
GO:0030627 biolink:NamedThing pre-mRNA 5'-splice site binding Binding to a pre-mRNA 5' splice site sequence. got7fsn_ti pre-mRNA 5' splice site binding molecular_function owl:Class
GO:0090600 biolink:NamedThing alpha-1,3-glucosidase activity Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose. got7fsn_ti tb 2014-08-22T15:00:45Z molecular_function owl:Class
GO:1900539 biolink:NamedThing fumonisin metabolic process The chemical reactions and pathways involving fumonisin. got7fsn_ti fumonisin metabolism tb 2012-05-11T12:53:29Z biological_process owl:Class
GO:0018545 biolink:NamedThing NAD(P)H nitroreductase activity Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative. got7fsn_ti UM-BBD_enzymeID:e0346 molecular_function owl:Class
GO:0047195 biolink:NamedThing diacylglycerol-sterol O-acyltransferase activity Catalysis of the reaction: sterol + 1,2-diacylglycerol = sterol ester + acylglycerol. got7fsn_ti 1,2-diacyl-sn-glycerol:sterol O-acyltransferase activity|1,2-diacyl-sn-glycerol:sterol acyl transferase activity RHEA:13301|EC:2.3.1.73|MetaCyc:2.3.1.73-RXN molecular_function owl:Class
GO:0045142 biolink:NamedThing triplex DNA binding Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination. got7fsn_ti molecular_function owl:Class
GO:0039666 biolink:NamedThing virion attachment to host cell pilus The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side. got7fsn_ti viral attachment to host cell pilus|pilus-mediated viral attachment to host cell|pilus-adsorption protein|pilus-mediated viral adsorption onto host cell bf 2013-08-29T13:31:10Z VZ:981 biological_process owl:Class
GO:0004422 biolink:NamedThing hypoxanthine phosphoribosyltransferase activity Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. got7fsn_ti HPRT|inosinate pyrophosphorylase activity|6-mercaptopurine phosphoribosyltransferase activity|inosinic pyrophosphorylase activity|IMP diphosphorylase activity|inosine 5'-phosphate pyrophosphorylase activity|IMP:diphosphate phospho-D-ribosyltransferase activity|IMP pyrophosphorylase activity|IMP-GMP pyrophosphorylase activity|purine-6-thiol phosphoribosyltransferase activity|hypoxanthine-guanine phosphoribosyltransferase activity|Transphosphoribosidase activity|6-hydroxypurine phosphoribosyltransferase activity|guanine-hypoxanthine phosphoribosyltransferase activity|HGPRTase activity|inosinic acid pyrophosphorylase activity MetaCyc:HYPOXANPRIBOSYLTRAN-RXN|EC:2.4.2.8|KEGG_REACTION:R01132|Reactome:R-HSA-74215|RHEA:17973 molecular_function owl:Class
GO:0004464 biolink:NamedThing leukotriene-C4 synthase activity Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). got7fsn_ti leukotriene A4:glutathione S-leukotrienyltransferase activity|LTC(4) synthetase activity|LTC4 synthetase activity|leukotriene C(4) synthetase activity|LTC4 synthase activity|leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)|LTC(4) synthase activity|(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)|leukotriene A(4):glutathione S-leukotrienyltransferase activity|leukotriene C4 synthetase activity|(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening) Note that this function was EC:2.5.1.37. RHEA:17617|MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN|EC:4.4.1.20|KEGG_REACTION:R03059|Reactome:R-HSA-266050 molecular_function owl:Class
GO:0071909 biolink:NamedThing determination of stomach left/right asymmetry Determination of the asymmetric location of the stomach with respect to the left and right halves of the organism. got7fsn_ti mah 2010-09-22T10:25:30Z biological_process owl:Class
GO:0036309 biolink:NamedThing protein localization to M-band Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere. got7fsn_ti protein localization to M line|protein localization to M disc|cellular protein localization to M-band|protein localization to mesophragma bf 2012-08-14T14:02:58Z biological_process owl:Class
GO:0062076 biolink:NamedThing acyl-CoA delta5-desaturase activity Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta5-acyl-CoA + acceptor + 2 H2O. got7fsn_ti acyl-CoA D5-desaturase activity|acyl-CoA delta(5)-desaturase activity|acyl-CoA (8-3)-desaturase dph 2018-09-24T15:33:59Z RHEA:46424|EC:1.14.19.44 molecular_function owl:Class
GO:0098673 biolink:NamedThing inhibition of host DNA replication by virus Any process by which a virus inhibits DNA replication in its host cell. Some bacteriophages are known to do this, possibly as a way of increasing the pool of nucleotides available for virus replication. got7fsn_ti dos 2017-01-17T15:58:15Z biological_process owl:Class
GO:0016602 biolink:NamedThing CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. got7fsn_ti NF-Y transcription factor complex|nuclear transcription factor Y complex|CBF complex cellular_component owl:Class
GO:0044104 biolink:NamedThing 2,5-dioxovalerate dehydrogenase (NAD+) activity Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+. got7fsn_ti 2,5-dioxopentanoate dehydrogenase (NAD+) activity|2,5-dioxopentanoate:NAD+ 5-oxidoreductase activity jl 2009-07-09T04:15:14Z molecular_function owl:Class
GO:0009921 biolink:NamedThing auxin efflux carrier complex The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell. got7fsn_ti cellular_component owl:Class
GO:0031687 biolink:NamedThing A2A adenosine receptor binding Binding to an A2A adenosine receptor. got7fsn_ti A2A adenosine receptor ligand molecular_function owl:Class
GO:0042425 biolink:NamedThing choline biosynthetic process The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. got7fsn_ti choline anabolism|choline synthesis|choline biosynthesis|choline formation MetaCyc:PWY-4762 biological_process owl:Class
GO:0097433 biolink:NamedThing dense body An electron dense body which may contain granules. got7fsn_ti pr 2012-11-22T15:34:04Z NIF_Subcellular:sao730872736 cellular_component owl:Class
GO:0106362 biolink:NamedThing protein-arginine N-acetylglucosaminyltransferase activity Catalysis of the reaction: L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP. got7fsn_ti hjd 2021-02-05T15:42:52Z RHEA:66632 molecular_function owl:Class
GO:0018549 biolink:NamedThing methanethiol oxidase activity Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide. got7fsn_ti MT-oxidase activity|methanethiol:oxygen oxidoreductase activity|methyl mercaptan oxidase activity|(MM)-oxidase activity|methylmercaptan oxidase activity UM-BBD_reactionID:r0209|EC:1.8.3.4|MetaCyc:METHANETHIOL-OXIDASE-RXN|RHEA:11812 molecular_function owl:Class
GO:0004644 biolink:NamedThing phosphoribosylglycinamide formyltransferase activity Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. got7fsn_ti 5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity|glycinamide ribonucleotide transformylase activity|GAR transformylase activity|GAR TFase activity|5'-phosphoribosylglycinamide transformylase activity|2-amino-N-ribosylacetamide 5'-phosphate transformylase activity|GAR formyltransferase activity|GART activity|10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity Reactome:R-HSA-73813|MetaCyc:GART-RXN|EC:2.1.2.2|RHEA:15053 molecular_function owl:Class
GO:0003284 biolink:NamedThing septum primum development The progression of the septum primum over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-20T10:12:26Z biological_process owl:Class
GO:0051044 biolink:NamedThing positive regulation of membrane protein ectodomain proteolysis Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis. got7fsn_ti up-regulation of membrane protein ectodomain proteolysis|activation of membrane protein ectodomain proteolysis|stimulation of membrane protein ectodomain proteolysis|up regulation of membrane protein ectodomain proteolysis|upregulation of membrane protein ectodomain proteolysis biological_process owl:Class
GO:0018182 biolink:NamedThing protein-heme linkage via 3'-L-histidine The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine). got7fsn_ti protein-haem linkage via 3'-L-histidine RESID:AA0276 biological_process owl:Class
GO:0075131 biolink:NamedThing induction by symbiont of host protein kinase-mediated signal transduction Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of protein kinase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by symbiont of host protein kinase-mediated signal transduction Note that this term is used to annotate gene products of the symbiont. To annotate host gene products, consider the biological process term "positive regulation by host of symbiont protein kinase-mediated signal transduction ; GO:0075100". biological_process owl:Class
GO:0070815 biolink:NamedThing peptidyl-lysine 5-dioxygenase activity Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 5-hydroxy-L-lysine + succinate + CO2. got7fsn_ti lysyl hydroxylase activity|protein lysine hydroxylase activity|peptide-lysine 5-dioxygenase activity|lysine hydroxylase activity|peptidyllysine, 2-oxoglutarate:oxygen 5-oxidoreductase activity|lysine-2-oxoglutarate dioxygenase activity|peptidyl-lysine, 2-oxoglutarate: oxygen oxidoreductase activity|lysine,2-oxoglutarate 5-dioxygenase activity mah 2009-07-09T11:42:07Z molecular_function owl:Class
GO:0060522 biolink:NamedThing inductive mesenchymal to epithelial cell signaling Signaling at short range from mesenchymal cells to cells of an epithelium that results in a developmental change in the epithelial cells. got7fsn_ti inductive mesenchymal to epithelial cell signalling biological_process owl:Class
GO:0050470 biolink:NamedThing trimethylamine dehydrogenase activity Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein. got7fsn_ti TMADh activity|trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating) MetaCyc:1.5.8.2-RXN|EC:1.5.8.2|RHEA:11864|UM-BBD_enzymeID:e0854 molecular_function owl:Class
GO:0043163 biolink:NamedThing cell envelope organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present. got7fsn_ti cell envelope organization and biogenesis|cell envelope organisation biological_process owl:Class
GO:0000705 biolink:NamedThing achiasmate meiosis I The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata. got7fsn_ti achiasmate meiosis I nuclear division biological_process owl:Class
GO:0050368 biolink:NamedThing tyrosine 2,3-aminomutase activity Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate. got7fsn_ti L-tyrosine 2,3-aminomutase activity|tyrosine alpha,beta-mutase activity MetaCyc:TYROSINE-23-AMINOMUTASE-RXN|KEGG_REACTION:R00739|EC:5.4.3.6|RHEA:15781 molecular_function owl:Class
GO:0050318 biolink:NamedThing tannase activity Catalysis of the reaction: digallate + H(2)O = 2 gallate + H(+). got7fsn_ti tannin acetylhydrolase activity|tannin acylhydrolase activity|tannase S EC:3.1.1.20|MetaCyc:TANNASE-RXN|KEGG_REACTION:R00053|RHEA:16365 molecular_function owl:Class
GO:0033909 biolink:NamedThing fucoidanase activity Catalysis of the endohydrolysis of 1,2-alpha-L-fucoside linkages in fucoidan without release of sulfate. got7fsn_ti poly(1,2-alpha-L-fucoside-4-sulfate) glycanohydrolase activity EC:3.2.1.211|MetaCyc:RXN-20949 molecular_function owl:Class
GO:0034934 biolink:NamedThing phenanthrene-4-carboxylate dioxygenase activity Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate. got7fsn_ti UM-BBD_reactionID:r0939|EC:1.13.11.- molecular_function owl:Class
GO:0031869 biolink:NamedThing prostacyclin receptor binding Binding to a prostacyclin receptor. got7fsn_ti prostanoid IP receptor binding|prostacyclin receptor ligand molecular_function owl:Class
GO:0047116 biolink:NamedThing 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase activity Catalysis of the reaction: NAD+ + 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate = NADH + CO2 + catechol. got7fsn_ti dihydrodihydroxybenzoate dehydrogenase activity|2-hydro-1,2-dihydroxybenzoate dehydrogenase activity|3,5-cyclohexadiene-1,2-diol-1-carboxylic acid dehydrogenase activity|DHB dehydrogenase activity|cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD+ oxidoreductase activity|DHBDH activity|(1R,6R)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating)|cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate:NAD(+) oxidoreductase activity|3,5-cyclohexadiene-1,2-diol-1-carboxylate dehydrogenase activity RHEA:11560|EC:1.3.1.25|MetaCyc:1.3.1.25-RXN molecular_function owl:Class
GO:0031815 biolink:NamedThing P2Y5 nucleotide receptor binding Binding to a P2Y5 nucleotide receptor. got7fsn_ti P2Y5 nucleotide receptor ligand molecular_function owl:Class
GO:0009825 biolink:NamedThing multidimensional cell growth The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes. got7fsn_ti cell growth in two dimensions|cell growth in three dimensions biological_process owl:Class
GO:0072637 biolink:NamedThing interleukin-32 production The appearance of interleukin-32 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-32 secretion|NK4 production|IL-32 production|interleukin-32 biosynthetic process|TAIF production|IL32 production bc 2020-02-21T10:26:40Z GO:0072638|GO:0150188 biological_process owl:Class
GO:0007608 biolink:NamedThing sensory perception of smell The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. got7fsn_ti olfaction|sense of smell|scent perception|smell perception Wikipedia:Olfaction biological_process owl:Class
GO:0030755 biolink:NamedThing quercetin 3-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone. got7fsn_ti flavonol 3-O-methyltransferase activity|flavonoid 3-methyltransferase activity|S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity RHEA:17673|EC:2.1.1.76|MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0033740 biolink:NamedThing hydroxylamine oxidoreductase activity Catalysis of the reactions: hydroxylamine + NH3 = hydrazine + H2O, and hydrazine + acceptor = N2 + reduced acceptor. got7fsn_ti hydroxylamine:acceptor oxidoreductase activity RHEA:23232|EC:1.7.2.8|MetaCyc:1.7.99.8-RXN molecular_function owl:Class
GO:0047251 biolink:NamedThing thiohydroximate beta-D-glucosyltransferase activity Catalysis of the reaction: phenylthioacetohydroximate + UDP-D-glucose = desulfoglucotropeolin + UDP. got7fsn_ti UDP-glucose:thiohydroximate S-beta-D-glucosyltransferase activity|UDP-glucose:N-hydroxy-2-phenylethanethioamide S-beta-D-glucosyltransferase activity|UDPG:thiohydroximate glucosyltransferase activity|thiohydroximate S-glucosyltransferase activity|uridine diphosphoglucose-thiohydroximate glucosyltransferase activity|N-hydroxythioamide S-beta-glucosyltransferase activity|desulfoglucosinolate-uridine diphosphate glucosyltransferase activity|thiohydroximate glucosyltransferase activity MetaCyc:2.4.1.195-RXN|EC:2.4.1.195|RHEA:13757 molecular_function owl:Class
GO:0033970 biolink:NamedThing N-malonylurea hydrolase activity Catalysis of the reaction: 3-oxo-3-ureidopropanoate + H(2)O = H(+) + malonate + urea. got7fsn_ti 3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming) activity|ureidomalonase activity KEGG_REACTION:R07629|MetaCyc:3.5.1.95-RXN|RHEA:17361|EC:3.5.1.95 molecular_function owl:Class
GO:0052597 biolink:NamedThing diamine oxidase activity Catalysis of the reaction: a diamine + H2O + O2 = a monoamine + NH3 + hydrogen peroxide. got7fsn_ti diamine:oxygen oxidoreductase (deaminating) activity EC:1.4.3.22|MetaCyc:RXN-9599 molecular_function owl:Class
GO:0035098 biolink:NamedThing ESC/E(Z) complex A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. got7fsn_ti PRC2 complex|Extra Sex Combs/Enhancer of Zeste complex cellular_component owl:Class
GO:0010409 biolink:NamedThing extensin metabolic process The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated. got7fsn_ti extensin metabolism biological_process owl:Class
GO:0032621 biolink:NamedThing interleukin-18 production The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-18 production|interleukin-18 biosynthetic process|IL1F4 production|IGIF production|interleukin-18 secretion GO:0072616|GO:0042241 biological_process owl:Class
GO:0034732 biolink:NamedThing transcription factor TFIIIB-alpha complex A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters. got7fsn_ti cellular_component owl:Class
GO:0000126 biolink:NamedThing transcription factor TFIIIB complex A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF. got7fsn_ti cellular_component owl:Class
GO:0035135 biolink:NamedThing post-embryonic anal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming. got7fsn_ti biological_process owl:Class
GO:0070936 biolink:NamedThing protein K48-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation. got7fsn_ti protein K48-linked polyubiquitination mah 2009-09-21T03:25:27Z biological_process owl:Class
GO:1902774 biolink:NamedThing late endosome to lysosome transport The directed movement of substances from late endosome to lysosome. got7fsn_ti prevacuolar compartment to lysosome transport an example of this is snapin in mouse (Q9Z266) in PMID:20920792 inferred from mutant phenotype pad 2014-03-17T16:32:36Z biological_process owl:Class
GO:0004034 biolink:NamedThing aldose 1-epimerase activity Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. got7fsn_ti mutarotase activity|aldose mutarotase activity EC:5.1.3.3|MetaCyc:ALDOSE-1-EPIMERASE-RXN|RHEA:10264 molecular_function owl:Class
GO:0016161 biolink:NamedThing beta-amylase activity Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. got7fsn_ti beta amylase activity|glycogenase activity|1,4-alpha-D-glucan maltohydrolase activity|saccharogen amylase activity MetaCyc:RXN-1827|EC:3.2.1.2|MetaCyc:RXN-12279 molecular_function owl:Class
GO:0045007 biolink:NamedThing depurination The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar. got7fsn_ti Wikipedia:Depurination biological_process owl:Class
GO:0097296 biolink:NamedThing activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway. got7fsn_ti activation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway|activation of initiator caspase activity Components of the DISC (death-inducing signaling complex) may be annotated to this term. These include ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer), and signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Note that GO:0097296 should only be used to annotate gene products directly involved in the initiation or start up of an inactive cysteine-type endopeptidase activity involved in the apoptotic signaling pathway (also known as an initiator caspase). If the evidence provided is not sufficient to account for direct activation of this enzymatic activity, consider using the more generic terms GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway or GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. pr 2012-05-02T03:19:35Z biological_process owl:Class
GO:2001269 biolink:NamedThing positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. got7fsn_ti positive regulation of cysteine-type endopeptidase activity involved in apoptotic signalling pathway|positive regulation of initiator caspase activity pr 2011-12-13T07:56:26Z biological_process owl:Class
GO:0018915 biolink:NamedThing ethylbenzene metabolic process The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels. got7fsn_ti ethylbenzene metabolism UM-BBD_pathwayID:ethb2 biological_process owl:Class
GO:0072035 biolink:NamedThing pre-tubular aggregate formation The cell adhesion process in which mesenchyme cells adhere to one another in the initial stages of the formation of the pre-tubular aggregate, the earliest recognizable structure of the kidney. got7fsn_ti mesenchymal cell condensation involved in renal vesicle formation|nephron epithelium formation mah 2010-01-25T03:03:10Z biological_process owl:Class
GO:0097628 biolink:NamedThing distal tip cell migration The orderly movement of a distal tip cell. got7fsn_ti pr 2014-08-20T16:06:53Z biological_process owl:Class
GO:0019123 biolink:NamedThing peptidyl-methionine racemization The racemization of peptidyl-methionine. got7fsn_ti GO:0018087|GO:0018369 RESID:AA0193 biological_process owl:Class
GO:0046539 biolink:NamedThing histamine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+). got7fsn_ti histamine 1-methyltransferase activity|histamine methyltransferase activity|S-adenosylmethionine-histamine N-methyltransferase activity|imidazolemethyltransferase activity|histamine-methylating enzyme|S-adenosyl-L-methionine:histamine N-tele-methyltransferase activity RHEA:19301|EC:2.1.1.8|Reactome:R-HSA-175993|KEGG_REACTION:R02155|MetaCyc:HISTAMINE-N-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0004821 biolink:NamedThing histidine-tRNA ligase activity Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). got7fsn_ti histidyl-transfer ribonucleate synthetase activity|L-histidine:tRNAHis ligase (AMP-forming)|histidine translase activity|histidyl-tRNA synthetase activity RHEA:17313|MetaCyc:HISTIDINE--TRNA-LIGASE-RXN|EC:6.1.1.21|Reactome:R-HSA-380234|Reactome:R-HSA-379844 molecular_function owl:Class
GO:0047448 biolink:NamedThing 5-dehydro-4-deoxyglucarate dehydratase activity Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucarate + H(+) = 2,5-dioxopentanoate + CO(2) + H(2)O. got7fsn_ti 5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating)|deoxyketoglucarate dehydratase activity|5-dehydro-4-deoxy-D-glucarate hydro-lyase (decarboxylating; 2,5-dioxopentanoate-forming)|D-4-deoxy-5-ketoglucarate hydro-lyase activity|5-keto-4-deoxy-glucarate dehydratase activity RHEA:24608|KEGG_REACTION:R02279|EC:4.2.1.41|MetaCyc:4.2.1.41-RXN molecular_function owl:Class
GO:0061749 biolink:NamedThing forked DNA-dependent helicase activity Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis. got7fsn_ti dph 2015-11-11T13:10:51Z molecular_function owl:Class
GO:0071043 biolink:NamedThing CUT metabolic process The chemical reactions and pathways involving cryptic unstable transcripts (CUTs), which are transcribed from intergenic regions. Many intergenic regions are heavily transcribed, but the transcripts are rarely detected due to rapid degradation by the nuclear exosome. got7fsn_ti krc 2009-07-29T02:31:31Z biological_process owl:Class
GO:0018143 biolink:NamedThing nucleic acid-protein covalent cross-linking The formation of a covalent cross-link between a nucleic acid and a protein. got7fsn_ti biological_process owl:Class
GO:0055049 biolink:NamedThing astral spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the presence of centrosomes. got7fsn_ti biological_process owl:Class
GO:0036164 biolink:NamedThing cell-abiotic substrate adhesion The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules. got7fsn_ti cell-abiotic surface adhesion bf 2012-03-27T11:18:33Z biological_process owl:Class
GO:0061031 biolink:NamedThing endodermal digestive tract morphogenesis The process in which the anatomical structures of the endodermal digestive tract are generated and organized. The endodermal digestive tract includes those portions of the digestive tract that are derived from endoderm. got7fsn_ti dph 2010-02-09T09:46:43Z biological_process owl:Class
GO:0150023 biolink:NamedThing apical dendrite arborization The process in which the anatomical structures of a dendritic tree are generated on the apical neuron side and organized into dendritic branches. got7fsn_ti bc 2017-12-22T11:56:05Z biological_process owl:Class
GO:0150021 biolink:NamedThing apical dendrite morphogenesis The process in which the anatomical structures of an apical dendrite are generated and organized. got7fsn_ti bc 2017-12-22T11:50:00Z biological_process owl:Class
GO:0050052 biolink:NamedThing leukotriene-E4 20-monooxygenase activity Catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+). got7fsn_ti leukotriene-E4 w-hydroxylase activity|leukotriene-E(4) omega-hydroxylase activity|leukotriene-E4 omega-hydroxylase activity|(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating) EC:1.14.13.34|MetaCyc:LEUKOTRIENE-E4-20-MONOOXYGENASE-RXN|KEGG_REACTION:R04256|RHEA:24120 molecular_function owl:Class
GO:0043734 biolink:NamedThing DNA-N1-methyladenine dioxygenase activity Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde. got7fsn_ti alpha-ketoglutarate-dependent dioxygenase|AlkB Reactome:R-HSA-112118|Reactome:R-HSA-112123 molecular_function owl:Class
GO:0009223 biolink:NamedThing pyrimidine deoxyribonucleotide catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti pyrimidine deoxyribonucleotide breakdown|pyrimidine deoxyribonucleotide degradation|pyrimidine deoxyribonucleotide catabolism biological_process owl:Class
GO:0001080 biolink:NamedThing nitrogen catabolite activation of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites krc 2010-10-27T03:32:34Z biological_process owl:Class
GO:0004940 biolink:NamedThing beta1-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors. got7fsn_ti beta1 adrenoceptor molecular_function owl:Class
GO:0015039 biolink:NamedThing NADPH-adrenodoxin reductase activity Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+. got7fsn_ti NADPH:adrenodoxin oxidoreductase activity|adrenodoxin-type ferredoxin reductase activity|adrenodoxin reductase activity Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'. MetaCyc:RXN-13685|EC:1.18.1.6|RHEA:42312 molecular_function owl:Class
GO:0034415 biolink:NamedThing tRNA 3'-trailer cleavage, exonucleolytic Exonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA. got7fsn_ti tRNA 3'-end cleavage, exonucleolytic|exonucleolytic tRNA 3'-trailer cleavage|exonucleolytic tRNA 3'-end cleavage biological_process owl:Class
GO:0043261 biolink:NamedThing laminin-12 complex A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains. got7fsn_ti laminin-213 complex cellular_component owl:Class
GO:1905369 biolink:NamedThing endopeptidase complex A protein complex which is capable of endopeptidase activity. got7fsn_ti An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay). bhm 2016-08-16T12:52:16Z cellular_component owl:Class
GO:0019651 biolink:NamedThing citrate catabolic process to diacetyl The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP. got7fsn_ti citrate fermentation to diacetyl|diacetyl fermentation biological_process owl:Class
GO:0009091 biolink:NamedThing homoserine catabolic process The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid. got7fsn_ti homoserine degradation|homoserine breakdown|homoserine catabolism MetaCyc:HOMOCYSDEGR-PWY biological_process owl:Class
GO:0102635 biolink:NamedThing 11-deoxycorticosterone reductase activity Catalysis of the reaction: 11-deoxycorticosterone + NADH + H+ <=> 4-pregnen-20,21-diol-3-one + NAD. got7fsn_ti RHEA:47716|MetaCyc:RXN-15607 molecular_function owl:Class
GO:0102323 biolink:NamedThing 2-isopropylphenol monooxygenase activity Catalysis of the reaction: 2-isopropylphenol + O2 + NADH + H+ = 3-isopropylcatechol + H2O + NAD. got7fsn_ti MetaCyc:RXN-13152|RHEA:63520 molecular_function owl:Class
GO:0038203 biolink:NamedThing TORC2 signaling A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components. got7fsn_ti TORC2 signal transduction bf 2013-12-09T14:43:29Z biological_process owl:Class
GO:0009024 biolink:NamedThing tagatose-6-phosphate kinase activity Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate. got7fsn_ti phosphotagatokinase activity|ATP:D-tagatose-6-phosphate 1-phosphotransferase activity RHEA:12420|MetaCyc:TAGAKIN-RXN|EC:2.7.1.144 molecular_function owl:Class
GO:0050420 biolink:NamedThing maltose synthase activity Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate. got7fsn_ti alpha-D-glucose-1-phosphate:alpha-D-glucose-1-phosphate 4-alpha-D-glucosyltransferase (dephosphorylating) MetaCyc:MALTOSE-SYNTHASE-RXN|EC:2.4.1.139|RHEA:22320 molecular_function owl:Class
GO:0030412 biolink:NamedThing formimidoyltetrahydrofolate cyclodeaminase activity Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+). got7fsn_ti formiminotetrahydrofolate cyclodeaminase activity|5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)|5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing) Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases. MetaCyc:4.3.1.4-RXN|RHEA:22736|EC:4.3.1.4|Reactome:R-HSA-70920|KEGG_REACTION:R02302 molecular_function owl:Class
GO:0038003 biolink:NamedThing G protein-coupled opioid receptor signaling pathway The series of molecular signals generated as a consequence of an opioid receptor binding to one of its physiological ligands. got7fsn_ti opioid receptor signalling pathway|opioid receptor signaling pathway https://github.com/geneontology/go-ontology/issues/21110 bf 2011-03-03T02:00:02Z Wikipedia:Opioid_receptor biological_process owl:Class
GO:0036076 biolink:NamedThing ligamentous ossification Ossification wherein bone tissue forms within ligamentous tissue. got7fsn_ti Ligamentous ossification may occur via replacement ossification or metaplastic ossification or both in any one instance. bf 2011-12-19T01:57:08Z biological_process owl:Class
GO:0002419 biolink:NamedThing T cell mediated cytotoxicity directed against tumor cell target The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. got7fsn_ti T-cell mediated cytotoxicity directed against tumor cell target|T lymphocyte mediated cytotoxicity directed against tumor cell target|T-lymphocyte mediated cytotoxicity directed against tumor cell target Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. biological_process owl:Class
GO:0047586 biolink:NamedThing 5'-acylphosphoadenosine hydrolase activity Catalysis of the reaction: 5'-acylphosphoadenosine + H2O = AMP + a carboxylate. got7fsn_ti 5'-acylphosphoadenosine acylhydrolase activity|5-phosphoadenosine hydrolase activity MetaCyc:5-ACYLPHOSPHOADENOSINE-HYDROLASE-RXN|EC:3.6.1.20|RHEA:16837 molecular_function owl:Class
GO:0090427 biolink:NamedThing activation of meiosis Any process that starts the inactive process of meiosis. got7fsn_ti tb 2012-05-04T09:50:19Z biological_process owl:Class
GO:0016206 biolink:NamedThing catechol O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol. got7fsn_ti catecholamine O-methyltransferase activity|catechol methyltransferase activity|COMT I|S-adenosyl-L-methionine:catechol O-methyltransferase activity|COMT II|S-COMT (soluble form of catechol-O-methyltransferase)|MB-COMT (membrane-bound form of catechol-O-methyltransferase) Reactome:R-HSA-8955010|MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN|EC:2.1.1.6|Reactome:R-HSA-175983 molecular_function owl:Class
GO:0036285 biolink:NamedThing SAGA complex assembly The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof. got7fsn_ti SAGA complex formation bf 2012-07-16T10:30:00Z biological_process owl:Class
GO:0102877 biolink:NamedThing alpha-copaene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-copaene + diphosphoric acid. got7fsn_ti EC:4.2.3.133|RHEA:33991|MetaCyc:RXN-8416 molecular_function owl:Class
GO:0071303 biolink:NamedThing cellular response to vitamin B3 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B3 stimulus. got7fsn_ti cellular response to niacin|cellular response to nicotinamide mah 2009-12-10T04:35:04Z biological_process owl:Class
GO:0071295 biolink:NamedThing cellular response to vitamin Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus. got7fsn_ti mah 2009-12-10T04:27:24Z biological_process owl:Class
GO:1990232 biolink:NamedThing phosphomannomutase complex A protein complex capable of phosphomannomutase activity. got7fsn_ti PMM-2 complex|PMM-2 dimer|PMM-1 complex|PMM-1 dimer bhm 2013-11-12T13:05:54Z cellular_component owl:Class
GO:0102340 biolink:NamedThing 3-oxo-behenoyl-CoA reductase activity Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA(4-) + NADP(3-) <=> 3-oxodocosanoyl-CoA + NADPH + H+. got7fsn_ti EC:1.1.1.330|MetaCyc:RXN-13299 molecular_function owl:Class
GO:0032448 biolink:NamedThing DNA hairpin binding Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences. got7fsn_ti molecular_function owl:Class
GO:0043776 biolink:NamedThing cobalt-precorrin-6B C5-methyltransferase activity Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7. got7fsn_ti cobalt-precorrin 6B C5-methyltransferase activity|precorrin-6Y C5,15-methyltransferase (decarboxylating)|precorrin-6 methyltransferase activity|precorrin-6Y methylase RHEA:36067|MetaCyc:RXN-8766 molecular_function owl:Class
GO:1901270 biolink:NamedThing lipooligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of lipooligosaccharide. got7fsn_ti lipooligosaccharide degradation|lipooligosaccharide breakdown|lipooligosaccharide catabolism yaf 2012-08-17T14:31:48Z biological_process owl:Class
GO:0009313 biolink:NamedThing oligosaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. got7fsn_ti oligosaccharide degradation|oligosaccharide breakdown|oligosaccharide catabolism|multicellular organismal oligosaccharide catabolic process GO:0051689 biological_process owl:Class
GO:0072190 biolink:NamedThing ureter urothelium development The process whose specific outcome is the progression of the urothelium of the ureter over time, from its formation to the mature structure. The urothelium is an epithelium that makes up the epithelial tube of the ureter. got7fsn_ti ureter epithelium development mah 2010-03-01T01:46:31Z biological_process owl:Class
GO:0098988 biolink:NamedThing G protein-coupled glutamate receptor activity Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity. got7fsn_ti G-protein coupled glutamate receptor activity molecular_function owl:Class
GO:0046942 biolink:NamedThing carboxylic acid transport The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). got7fsn_ti biological_process owl:Class
GO:0014869 biolink:NamedThing detection of muscle inactivity The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0014870 biolink:NamedThing response to muscle inactivity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. got7fsn_ti biological_process owl:Class
GO:0047039 biolink:NamedThing tetrahydroxynaphthalene reductase activity Catalysis of the reaction: NADP+ + scytalone = NADPH + H+ + 1,3,6,8-naphthalenetetrol. got7fsn_ti T4HN reductase activity|scytalone:NADP+ delta5-oxidoreductase activity MetaCyc:1.1.1.252-RXN|EC:1.1.1.252|RHEA:21908 molecular_function owl:Class
GO:0099555 biolink:NamedThing trans-synaptic signaling by nitric oxide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0047383 biolink:NamedThing guanidinodeoxy-scyllo-inositol-4-phosphatase activity Catalysis of the reaction: 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H(2)O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate. got7fsn_ti 1-guanidino-scyllo-inositol 4-phosphatase activity|1-guanidino-1-deoxy-scyllo-inositol-4-P phosphohydrolase activity|1-guanidino-1-deoxy-scyllo-inositol-4-phosphate 4-phosphohydrolase activity MetaCyc:3.1.3.40-RXN|RHEA:15777|KEGG_REACTION:R03496|EC:3.1.3.40 molecular_function owl:Class
GO:0070911 biolink:NamedThing global genome nucleotide-excision repair The nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome. got7fsn_ti global genome NER|GG-NER|global genomic repair|global genomic nucleotide-excision repair|GGR mah 2009-09-09T03:13:11Z biological_process owl:Class
GO:0004439 biolink:NamedThing phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. got7fsn_ti PtdIns(4,5)P2 5-phosphatase activity|phosphatidylinositol-bisphosphatase activity|triphosphoinositide phosphatase activity|PI(4,5)P2 5-phosphatase activity|phosphatidylinositol 4,5-bisphosphate phosphatase activity|triphosphoinositide phosphomonoesterase activity|PtdIns(4,5)P(2) 5-phosphatase activity|phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity GO:0001668 Reactome:R-HSA-1675824|EC:3.1.3.36|Reactome:R-HSA-8868648|MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN|KEGG_REACTION:R04404|RHEA:22764|Reactome:R-HSA-1676177 molecular_function owl:Class
GO:0019458 biolink:NamedThing methionine catabolic process via 2-oxobutanoate The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate. got7fsn_ti methionine degradation via 2-oxobutanoate|methionine breakdown via 2-oxobutanoate MetaCyc:PWY-701 biological_process owl:Class
GO:0016871 biolink:NamedThing cycloartenol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol. got7fsn_ti oxidosqualene:cycloartenol cyclase activity|2,3-epoxysqualene--cycloartenol cyclase activity|2,3-oxidosqualene-cycloartenol cyclase activity|2,3-epoxysqualene cycloartenol-cyclase activity|squalene-2,3-epoxide-cycloartenol cyclase activity|(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming) EC:5.4.99.8|KEGG_REACTION:R03200|MetaCyc:CYCLOARTENOL-SYNTHASE-RXN|RHEA:21308 molecular_function owl:Class
GO:0045439 biolink:NamedThing isopenicillin-N epimerase activity Catalysis of the reaction: isopenicillin N = penicillin N. got7fsn_ti isopenicillin N epimerase activity|penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity RHEA:20033|MetaCyc:5.1.1.17-RXN|KEGG_REACTION:R04147|EC:5.1.1.17 molecular_function owl:Class
GO:0140376 biolink:NamedThing innate immune receptor activity Receiving a signal and transmitting it in a cell to initiate an innate immune response. got7fsn_ti pg 2019-10-18T14:21:28Z molecular_function owl:Class
GO:0017113 biolink:NamedThing dihydropyrimidine dehydrogenase (NADP+) activity Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+. got7fsn_ti DPD|5,6-dihydrouracil:NADP+ 5-oxidoreductase activity|4,5-dihydrothymine: oxidoreductase activity|dihydrothymine dehydrogenase activity|hydropyrimidine dehydrogenase activity|dihydrouracil dehydrogenase (NADP+) activity|DHU dehydrogenase activity|dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)|dihydropyrimidine dehydrogenase activity|DHPDH|dihydrouracil dehydrogenase (NADP) EC:1.3.1.2|RHEA:18093|Reactome:R-HSA-73616|Reactome:R-HSA-73585|MetaCyc:1.3.1.2-RXN molecular_function owl:Class
GO:0018015 biolink:NamedThing N-terminal peptidyl-phenylalanine methylation The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine. got7fsn_ti RESID:AA0065 biological_process owl:Class
GO:0036178 biolink:NamedThing filamentous growth of a population of unicellular organisms in response to neutral pH The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus. got7fsn_ti bf 2012-03-29T01:43:47Z biological_process owl:Class
GO:0047379 biolink:NamedThing ADP-dependent short-chain-acyl-CoA hydrolase activity Catalysis of the reaction: H2O + a short-chain acyl-CoA = a short-chain carboxylate + CoA. got7fsn_ti ADP-dependent short-chain acyl coenzyme A hydrolase activity|ADP-dependent propionyl-CoA thioesterase activity|ADP-dependent short-chain acyl-CoA hydrolase activity|ADP-dependent short-chain acyl-CoA thioesterase activity|ADP-dependent-short-chain-acyl-CoA hydrolase activity|ADP-dependent propionyl-CoA hydrolase activity|ADP-dependent propionyl coenzyme A hydrolase activity MetaCyc:3.1.2.18-RXN|EC:3.1.2.18 molecular_function owl:Class
GO:0030788 biolink:NamedThing precorrin-2 C20-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A. got7fsn_ti S-adenosyl-L-methionine--precorrin-2 methyltransferase activity|S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity RHEA:16841|MetaCyc:2.1.1.130-RXN|EC:2.1.1.130|KEGG_REACTION:R03948 molecular_function owl:Class
GO:0004138 biolink:NamedThing deoxyguanosine kinase activity Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+). got7fsn_ti deoxyguanosine kinase (phosphorylating)|ATP:deoxyguanosine 5'-phosphotransferase activity|2'-deoxyguanosine kinase activity|(dihydroxypropoxymethyl)guanine kinase activity|NTP-deoxyguanosine 5'-phosphotransferase activity KEGG_REACTION:R01967|RHEA:19201|EC:2.7.1.113|MetaCyc:DEOXYGUANOSINE-KINASE-RXN molecular_function owl:Class
GO:0009249 biolink:NamedThing protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine. got7fsn_ti protein-lipoic acid cofactor linkage|peptidyl-lysine lipoylation GO:0018055 biological_process owl:Class
GO:0106304 biolink:NamedThing mannogen biosynthetic process The chemical reactions and pathways resulting in the formation of mannogen, a mannose-containing polysaccharide that is a major energy reserve in Leishmania. got7fsn_ti beta-1,2-mannan biosynthetic process|mannogen biosynthesis|mannogen anabolism|mannogen synthesis|mannogen formation hjd 2020-09-09T13:52:26Z biological_process owl:Class
GO:0031848 biolink:NamedThing protection from non-homologous end joining at telomere A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse. got7fsn_ti protection from NHEJ-mediated telomere fusion biological_process owl:Class
GO:0043247 biolink:NamedThing telomere maintenance in response to DNA damage Any process that occur in response to the presence of critically short or damaged telomeres. got7fsn_ti DNA damage response, telomere maintenance biological_process owl:Class
GO:0062176 biolink:NamedThing R-loop disassembly A DNA metabolic process that results in the disassembly of R-loops. R-loops are three-stranded nucleic acid structures consisitng of an RNA:DNA heteroduplex and a looped-out non-template strand. Aberrant formation and persistence of R-loops block transcription elongation and cause DNA damage. Mechanisms that resolve R-loops are essential for genome stability. got7fsn_ti dph 2019-11-19T12:47:04Z biological_process owl:Class
GO:0003117 biolink:NamedThing regulation of vasoconstriction by circulating norepinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream. got7fsn_ti regulation of vasoconstriction by circulating noradrenaline biological_process owl:Class
GO:0003116 biolink:NamedThing regulation of vasoconstriction by norepinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings. got7fsn_ti biological_process owl:Class
GO:0035212 biolink:NamedThing cell competition in a multicellular organism Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells. got7fsn_ti biological_process owl:Class
GO:0005523 biolink:NamedThing tropomyosin binding Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. got7fsn_ti molecular_function owl:Class
GO:0071082 biolink:NamedThing alpha9-beta1 integrin-tenascin complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the extracellular matrix protein tenascin. got7fsn_ti ITGA9-ITGB1-TNC complex mah 2009-11-06T04:43:58Z cellular_component owl:Class
GO:0045175 biolink:NamedThing basal protein localization Any process in which a protein is transported to, or maintained in, basal regions of the cell. got7fsn_ti establishment and maintenance of protein localization in basal part of cell|basal protein localisation|establishment and maintenance of basal protein localization biological_process owl:Class
GO:0098806 biolink:NamedThing deadenylation involved in gene silencing by miRNA Shortening of the poly(A) tail of a nuclear-transcribed mRNA following miRNA binding to mRNA, resulting in destabilization of the mRNA and a reduction in the efficiency of its translation. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20568 biological_process owl:Class
GO:0044305 biolink:NamedThing calyx of Held The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. got7fsn_ti jl 2010-02-05T02:33:20Z NIF_Subcellular:sao1684283879 cellular_component owl:Class
GO:0080059 biolink:NamedThing flavonol 3-O-arabinosyltransferase activity Catalysis of the reaction: UDP-arabinose + a flavonol = UDP + a flavonol 3-O-D-arabinoside. got7fsn_ti dhl 2009-04-13T02:55:11Z molecular_function owl:Class
GO:0090547 biolink:NamedThing response to low humidity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of low humidity stimulus, reduced moisture in the atmosphere. got7fsn_ti tb 2013-04-17T13:46:28Z biological_process owl:Class
GO:0046978 biolink:NamedThing TAP1 binding Binding to the TAP1 subunit of TAP (transporter associated with antigen processing) protein. got7fsn_ti molecular_function owl:Class
GO:1903491 biolink:NamedThing response to simvastatin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a simvastatin stimulus. Simvastatin is a statin used as a cholesterol-lowering and anti-cardiovascular disease drug. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. hp 2014-09-25T10:58:06Z biological_process owl:Class
GO:0036273 biolink:NamedThing response to statin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties. got7fsn_ti response to HMG-CoA reductase inhibitor|response to hydroxymethylglutaryl-CoA reductase inhibitor Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. bf 2012-07-09T01:54:01Z biological_process owl:Class
GO:0019481 biolink:NamedThing L-alanine catabolic process, by transamination The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination. got7fsn_ti L-alanine degradation, by transamination|L-alanine breakdown, by transamination MetaCyc:ALANINE-DEG3-PWY biological_process owl:Class
GO:0019248 biolink:NamedThing D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde. got7fsn_ti D-lactate synthesis from methylglyoxal via (R)-lactaldehyde|D-lactate formation from methylglyoxal via (R)-lactaldehyde|D-lactate anabolism from methylglyoxal via (R)-lactaldehyde MetaCyc:MGLDLCTANA-PWY biological_process owl:Class
GO:0051443 biolink:NamedThing positive regulation of ubiquitin-protein transferase activity Any process that activates, maintains or increases the rate of ubiquitin transferase activity. got7fsn_ti ubiquitin transferase activator|up regulation of ubiquitin ligase activity|anaphase-promoting complex activator|positive regulation of ubiquitin transferase activity|APC activator|stimulation of ubiquitin transferase activity|APC activation|SCF complex activator|upregulation of ubiquitin transferase activity|anaphase promoting complex activator|up-regulation of ubiquitin transferase activity|activation of ubiquitin transferase activity biological_process owl:Class
GO:0031398 biolink:NamedThing positive regulation of protein ubiquitination Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein. got7fsn_ti upregulation of protein ubiquitination|up-regulation of protein ubiquitination|activation of protein ubiquitination|up regulation of protein ubiquitination|stimulation of protein ubiquitination biological_process owl:Class
GO:0043827 biolink:NamedThing tRNA (adenine-57, 58-N(1)-) methyltransferase activity Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA. got7fsn_ti TrmI|tRNA (m1A) MTase|tRNA (adenine-57, 58-N1-) methyltransferase activity|tRNA (adenine-57, 58 N1-) methyltransferase activity molecular_function owl:Class
GO:0050541 biolink:NamedThing beta,beta-carotene-9',10'-dioxygenase activity Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone. got7fsn_ti b,b-carotene-9',10'-dioxygenase activity molecular_function owl:Class
GO:0031727 biolink:NamedThing CCR2 chemokine receptor binding Binding to a CCR2 chemokine receptor. got7fsn_ti CCR2 chemokine receptor ligand|monocyte chemoattractant protein 1 receptor binding molecular_function owl:Class
GO:0070769 biolink:NamedThing alphaIIb-beta3 integrin-CIB complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to CIB, a protein that binds calcium as well as the alphaIIb-beta3 integrin. got7fsn_ti ITGA2B-ITGB3-CIB1 complex mah 2009-06-29T05:20:01Z cellular_component owl:Class
GO:0070017 biolink:NamedThing alphav-beta3 integrin-thrombospondin complex A protein complex that consists of an alphav-beta3 integrin complex bound to thrombospondin. got7fsn_ti ITGAV-ITGB3-THBS1 complex cellular_component owl:Class
GO:0030448 biolink:NamedThing hyphal growth Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls. got7fsn_ti formation of symbiont invasive hypha in host|symbiont invasive hypha formation within host|formation of symbiont invasive hypha within host|formation of symbiont invasive hypha within host during symbiotic interaction|invasive hyphal growth https://github.com/geneontology/go-ontology/issues/19013 GO:0075061 biological_process owl:Class
GO:0009588 biolink:NamedThing UV-A, blue light phototransduction The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm. got7fsn_ti violet-sensitive opsin|short-wave-sensitive opsin|blue-sensitive opsin biological_process owl:Class
GO:0008838 biolink:NamedThing diaminopropionate ammonia-lyase activity Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3. got7fsn_ti 2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)|diaminopropionatase activity|2,3-diaminopropionate ammonia-lyase activity|alpha,beta-diaminopropionate ammonia-lyase activity RHEA:22084|MetaCyc:4.3.1.15-RXN|EC:4.3.1.15 molecular_function owl:Class
GO:0018062 biolink:NamedThing peptidyl-tryptophan succinylation The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan. got7fsn_ti RESID:AA0130 biological_process owl:Class
GO:0036336 biolink:NamedThing dendritic cell migration The movement of a dendritic cell within or between different tissues and organs of the body. got7fsn_ti bf 2012-09-05T10:24:46Z biological_process owl:Class
GO:0051071 biolink:NamedThing 4,6-pyruvylated galactose residue metabolic process The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain. got7fsn_ti 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolism|PvGal metabolic process|4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process|PvGal metabolism|4,6-pyruvylated galactose residue metabolism biological_process owl:Class
GO:0102539 biolink:NamedThing UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-14769 molecular_function owl:Class
GO:0034701 biolink:NamedThing tripeptidase activity Catalysis of the hydrolysis of a tripeptide. got7fsn_ti MetaCyc:3.4.11.4-RXN|EC:3.4.13.- molecular_function owl:Class
GO:1990346 biolink:NamedThing BID-BCL-xl complex A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti bhm 2014-03-25T00:18:41Z cellular_component owl:Class
GO:0072639 biolink:NamedThing interleukin-33 production The appearance of interleukin-33 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-33 production|interleukin-33 secretion|C9orf26 production|NF-HEV production|interleukin-33 biosynthetic process|IL33 production|IL1F11 production GO:0072640|GO:0150126 biological_process owl:Class
GO:0102515 biolink:NamedThing pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity Catalysis of the reaction: pelargonidin 3-O-beta-D-glucoside + 1-O-feruloyl-beta-D-glucose <=> pelargonidin 3,7-di-O-beta-D-glucoside + ferulate + H+. got7fsn_ti MetaCyc:RXN-14447 molecular_function owl:Class
GO:0102212 biolink:NamedThing unsaturated chondroitin disaccharide hydrolase activity Catalysis of the reaction: beta-D-4-deoxy-Delta(4)-GlcpA-(1->3)-beta-D-GalpNAc6S + H2O = 5-dehydro-4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine 6-sulfate. got7fsn_ti RHEA:31647|EC:3.2.1.180|MetaCyc:RXN-12177 molecular_function owl:Class
GO:0005163 biolink:NamedThing nerve growth factor receptor binding Binding to a nerve growth factor receptor. got7fsn_ti nerve growth factor receptor ligand|NGF receptor binding|neurotrophin molecular_function owl:Class
GO:0050621 biolink:NamedThing tryptophan alpha,beta-oxidase activity Catalysis of the reaction: L-tryptophan + O(2) = alpha,beta-didehydrotryptophan + H(2)O(2) + H(+). got7fsn_ti L-tryptophan alpha,beta-dehydrogenase activity|tryptophan a,b-oxidase activity|L-tryptophan:oxygen alpha,beta-oxidoreductase activity|L-tryptophan 2',3'-oxidase activity Note that this was EC:1.4.3.17. MetaCyc:1.4.3.17-RXN|KEGG_REACTION:R05317|EC:1.3.3.10|RHEA:19901 molecular_function owl:Class
GO:0005052 biolink:NamedThing peroxisome matrix targeting signal-1 binding Binding to a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L. got7fsn_ti PEX5|PTS1 receptor|peroxisome targeting signal-1 binding|peroxisomal targeting signal 1 (PTS1) binding|peroxisome targeting signal-1 receptor|PTS1 binding molecular_function owl:Class
GO:0018830 biolink:NamedThing gamma-hexachlorocyclohexane dehydrochlorinase activity Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene. got7fsn_ti UM-BBD_enzymeID:e0359|EC:4.5.1.- molecular_function owl:Class
GO:0140621 biolink:NamedThing type I pilus A short filamentous structure on the surface of a bacterial cell distinguished from other pili by their D-mannose-sensitive agglutinatination of erythrocytes. In E. coli, type I pili consist of a short tip fibrillum made up of the adhesin protein (FimH) and two minor subunits (FimG and FimF) that is joined to the pilus rod, a homopolymer of ~1000 FimA subunits. got7fsn_ti type I fimbriae|type I pili|type 1 pilus https://github.com/geneontology/go-ontology/issues/14470 pg 2021-03-10T10:24:04Z cellular_component owl:Class
GO:0022407 biolink:NamedThing regulation of cell-cell adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. got7fsn_ti biological_process owl:Class
GO:0010343 biolink:NamedThing singlet oxygen-mediated programmed cell death Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes. got7fsn_ti programmed cell death in response to singlet oxygen|light-dependent programmed cell death biological_process owl:Class
GO:0006771 biolink:NamedThing riboflavin metabolic process The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). got7fsn_ti vitamin G metabolism|vitamin B2 metabolism|riboflavin metabolism|vitamin G metabolic process|vitamin B2 metabolic process Wikipedia:Riboflavin biological_process owl:Class
GO:0021967 biolink:NamedThing corticospinal neuron axon guidance through the cerebral cortex The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues. got7fsn_ti corticospinal neuron axon pathfinding through the cerebral cortex biological_process owl:Class
GO:0140650 biolink:NamedThing radial glia-guided pyramidal neuron migration The radial migration of a pyramidal neuron along radial glial cells. got7fsn_ti radial glia-dependent neuronal migration https://github.com/geneontology/go-ontology/issues/21476 pg 2021-05-25T12:48:12Z biological_process owl:Class
GO:0015304 biolink:NamedThing glucose uniporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in). got7fsn_ti galactose, glucose uniporter activity molecular_function owl:Class
GO:1990580 biolink:NamedThing regulation of cytoplasmic translational termination Any process that modulates the frequency, rate or extent of cytoplasmic translational termination. got7fsn_ti vw 2014-12-10T15:48:55Z biological_process owl:Class
GO:0003954 biolink:NamedThing NADH dehydrogenase activity Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. got7fsn_ti NADH diaphorase activity|NADH:(acceptor) oxidoreductase activity|NADH hydrogenase activity|NADH oxidoreductase activity|dihydrocodehydrogenase I dehydrogenase activity|diphosphopyrinase activity|type 1 dehydrogenase activity|NADH-menadione oxidoreductase activity|dihydronicotinamide adenine dinucleotide dehydrogenase activity|NADH:cytochrome c oxidoreductase activity|diphosphopyridine diaphorase activity|beta-NADH dehydrogenase dinucleotide activity|reduced diphosphopyridine nucleotide diaphorase activity|NADH2 dehydrogenase activity|diaphorase activity|type I dehydrogenase activity|cytochrome c reductase activity|DPNH diaphorase activity|NADH:acceptor oxidoreductase activity MetaCyc:NADH-DEHYDROGENASE-RXN|RHEA:11356 molecular_function owl:Class
GO:0052907 biolink:NamedThing 23S rRNA (adenine(1618)-N(6))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA. got7fsn_ti rRNA large subunit methyltransferase F activity|M(6)A(1618) activity EC:2.1.1.181|KEGG_REACTION:R07232|MetaCyc:RXN-11596|RHEA:16497 molecular_function owl:Class
GO:0043842 biolink:NamedThing Kdo transferase activity Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP. got7fsn_ti 3-deoxy-D-manno-octulosonic-acid transferase activity|WaaA|kdtA EC:2.4.99.13|MetaCyc:KDOTRANS-RXN|EC:2.4.99.15|EC:2.4.99.12|EC:2.4.99.14|MetaCyc:KDOTRANS2-RXN molecular_function owl:Class
GO:0050050 biolink:NamedThing leucine N-acetyltransferase activity Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H(+). got7fsn_ti acetyl-CoA:L-leucine N-acetyltransferase activity|leucine acetyltransferase activity RHEA:20089|EC:2.3.1.66|KEGG_REACTION:R01089|MetaCyc:LEUCINE-N-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:0140634 biolink:NamedThing CARD8 inflammasome complex An inflammasome complex that consists of CARD8 and CASP1. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21092 pg 2021-04-09T11:24:48Z cellular_component owl:Class
GO:0052086 biolink:NamedThing suppression by symbiont of host B-cell mediated immune response Any process in which a symbiont stops, prevents, or reduces the frequency, rate or extent of the B-cell mediated immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti down-regulation by symbiont of host B-cell mediated immune response|inhibition by symbiont of host B-cell mediated immune response|downregulation by symbiont of host B-cell mediated immune response|down regulation by symbiont of host B-cell mediated immune response|negative regulation by organism of B-cell mediated immune response of other organism involved in symbiotic interaction GO:0052281 biological_process owl:Class
GO:0019628 biolink:NamedThing urate catabolic process The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine. got7fsn_ti urate catabolism|uric acid catabolic process|urate breakdown|urate degradation MetaCyc:P165-PWY biological_process owl:Class
GO:0034966 biolink:NamedThing intronic box H/ACA snoRNA processing Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA. got7fsn_ti biological_process owl:Class
GO:0002133 biolink:NamedThing polycystin complex A stable heterodimeric complex composed of polycystin-1 and polycystin-2. got7fsn_ti Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant). cellular_component owl:Class
GO:0033211 biolink:NamedThing adiponectin-activated signaling pathway A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti adiponectin-mediated signaling pathway|adipocytokine signaling pathway|adiponectin-mediated signalling pathway biological_process owl:Class
GO:0097616 biolink:NamedThing positive regulation by host of symbiont type IV pilus-dependent motility Any process in which an organism activates, maintains or increases the frequency, rate or extent of the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti positive regulation by host of bacterial type IV pilus-dependent motility pr 2014-06-10T13:19:51Z biological_process owl:Class
GO:0097615 biolink:NamedThing modulation by host of symbiont type IV pilus-dependent motility The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by host of bacterial type IV pilus-dependent motility pr 2014-06-10T13:17:13Z biological_process owl:Class
GO:2001156 biolink:NamedThing regulation of proline catabolic process to glutamate Any process that modulates the frequency, rate or extent of proline catabolic process to glutamate. got7fsn_ti regulation of proline degradation to glutamate|regulation of proline breakdown to glutamate|regulation of proline oxidation mcc 2011-10-25T08:54:37Z biological_process owl:Class
GO:0009970 biolink:NamedThing cellular response to sulfate starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate. got7fsn_ti cellular response to sulphate starvation biological_process owl:Class
GO:0050284 biolink:NamedThing sinapate 1-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose. got7fsn_ti uridine diphosphoglucose-sinapate glucosyltransferase activity|UDPglucose:sinapate D-glucosyltransferase activity|uridine 5'-diphosphoglucose-hydroxycinnamic acid acylglucosyltransferase activity|UDPglucose:sinapic acid glucosyltransferase activity|UDP-glucose:sinapate D-glucosyltransferase activity EC:2.4.1.120|RHEA:13305|MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0060328 biolink:NamedThing cytoplasmic actin-based contraction involved in forward cell motility The actin filament-based movement by which cytoplasmic actin filaments slide past one another resulting in a contraction that propels the cell in the direction that has been defined as the front of the cell. got7fsn_ti cytoplasmic actin-based contraction involved in forward cell locomotion biological_process owl:Class
GO:0061017 biolink:NamedThing hepatoblast differentiation The process in which a relatively unspecialized cell acquires specialized features of a hepatoblast. A hepatoblast is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes. got7fsn_ti dph 2010-02-02T09:08:03Z biological_process owl:Class
GO:0010117 biolink:NamedThing photoprotection Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis. got7fsn_ti biological_process owl:Class
GO:0050377 biolink:NamedThing UDP-glucose 4,6-dehydratase activity Catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose. got7fsn_ti UDPglucose 4,6-hydro-lyase activity|UDP-D-glucose oxidoreductase activity|UDP-glucose 4,6-hydro-lyase (UDP-4-dehydro-6-deoxy-D-glucose-forming)|UDP-D-glucose-4,6-hydrolyase activity|UDPglucose 4,6-dehydratase activity|UDP-glucose 4,6-hydro-lyase activity RHEA:21500|EC:4.2.1.76|MetaCyc:UDP-GLUCOSE-46-DEHYDRATASE-RXN|KEGG_REACTION:R00293 molecular_function owl:Class
GO:0050366 biolink:NamedThing tyramine N-feruloyltransferase activity Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine. got7fsn_ti feruloyltyramine synthase activity|feruloyl-CoA:tyramine N-(hydroxycinnamoyl)transferase activity|tyramine feruloyltransferase activity|tyramine N-feruloyl-CoA transferase activity|feruloyl-CoA tyramine N-feruloyl-CoA transferase activity EC:2.3.1.110|MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN|RHEA:19685 molecular_function owl:Class
GO:0019835 biolink:NamedThing cytolysis The rupture of cell membranes and the loss of cytoplasm. got7fsn_ti holin|bacteriocin activity|lysin activity|lysis|necrosis|autolysin activity|bacteriolytic toxin activity Wikipedia:Cytolysis biological_process owl:Class
GO:0080042 biolink:NamedThing ADP-glucose pyrophosphohydrolase activity Catalysis of the reaction: ADP-glucose + H2O = AMP + glucose-1-phosphate. got7fsn_ti molecular_function owl:Class
GO:1903303 biolink:NamedThing negative regulation of pyruvate kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of pyruvate kinase activity. got7fsn_ti negative regulation of phosphoenolpyruvate kinase activity|negative regulation of phosphoenol transphosphorylase activity|down regulation of phosphoenol transphosphorylase activity|downregulation of phosphoenolpyruvate kinase activity|inhibition of pyruvate kinase activity|downregulation of pyruvate kinase activity|inhibition of phosphoenol transphosphorylase activity|down regulation of phosphoenolpyruvate kinase activity|down-regulation of phosphoenolpyruvate kinase activity|inhibition of phosphoenolpyruvate kinase activity|down-regulation of pyruvate kinase activity|downregulation of phosphoenol transphosphorylase activity|negative regulation of ATP:pyruvate 2-O-phosphotransferase activity|downregulation of ATP:pyruvate 2-O-phosphotransferase activity|down-regulation of ATP:pyruvate 2-O-phosphotransferase activity|down regulation of pyruvate kinase activity|down-regulation of phosphoenol transphosphorylase activity|inhibition of ATP:pyruvate 2-O-phosphotransferase activity|down regulation of ATP:pyruvate 2-O-phosphotransferase activity mr 2014-08-15T23:25:58Z biological_process owl:Class
GO:0051348 biolink:NamedThing negative regulation of transferase activity Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. got7fsn_ti down-regulation of transferase activity|transferase inhibitor|downregulation of transferase activity|inhibition of transferase activity|down regulation of transferase activity This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. biological_process owl:Class
GO:0042496 biolink:NamedThing detection of diacyl bacterial lipopeptide The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups. got7fsn_ti detection of diacylated bacterial lipoprotein|perception of diacylated bacterial lipopeptide|perception of diacylated bacterial lipoprotein Note that bacterial lipopeptides are derived from bacterial lipoproteins, but the two terms are sometimes used interchangeably in the literature. biological_process owl:Class
GO:0102600 biolink:NamedThing cytochrome P450 dependent 12,13beta-epoxy-beta-amyrin hydroxylase activity Catalysis of the reaction: 12,13beta-epoxy-beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-16beta-hydroxy-beta-amyrin + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-15384 molecular_function owl:Class
GO:0072528 biolink:NamedThing pyrimidine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. got7fsn_ti pyrimidine-containing compound formation|pyrimidine-containing compound synthesis|pyrimidine and derivative biosynthetic process|pyrimidine-containing compound biosynthesis|pyrimidine-containing compound anabolism mah 2011-01-04T03:27:36Z biological_process owl:Class
GO:0018715 biolink:NamedThing 9-phenanthrol UDP-glucuronosyltransferase activity Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP. got7fsn_ti UM-BBD_reactionID:r0567 molecular_function owl:Class
GO:0035632 biolink:NamedThing mitochondrial prohibitin complex A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death. got7fsn_ti mitochondrial inner membrane prohibitin complex bf 2010-12-21T10:38:59Z cellular_component owl:Class
GO:0044508 biolink:NamedThing glucagon-like peptide 1 receptor activity Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein. got7fsn_ti jl 2012-02-23T04:50:25Z molecular_function owl:Class
GO:0048533 biolink:NamedThing sporocyte differentiation The process in which a relatively unspecialized floral cell acquires the specialized features of a sporocyte. Sporocytes are the haploid spores of angiosperms. Once formed, they undergo meiotic divisions to form microspores and megaspores. got7fsn_ti sporocyte development|sporocyte morphogenesis biological_process owl:Class
GO:0036187 biolink:NamedThing cell growth mode switching, budding to filamentous The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans. got7fsn_ti yeast to hyphal transition bf 2012-04-18T11:32:57Z biological_process owl:Class
GO:0055131 biolink:NamedThing C3HC4-type RING finger domain binding Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. got7fsn_ti jid 2009-10-22T02:20:33Z molecular_function owl:Class
GO:0010068 biolink:NamedThing protoderm histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the epidermis. got7fsn_ti biological_process owl:Class
GO:0086053 biolink:NamedThing AV node cell to bundle of His cell communication by electrical coupling The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. got7fsn_ti atrioventricular node cell to bundle of His cell communication by electrical coupling dph 2011-11-16T12:31:08Z biological_process owl:Class
GO:0032040 biolink:NamedThing small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. got7fsn_ti SSU processome|small subunit processome cellular_component owl:Class
GO:0022876 biolink:NamedThing protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti galactosamine PTS transporter activity molecular_function owl:Class
GO:0019196 biolink:NamedThing galactosamine transmembrane transporter activity Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative. got7fsn_ti galactosamine porter activity GO:0019195 molecular_function owl:Class
GO:0004071 biolink:NamedThing aspartate-ammonia ligase activity Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine. got7fsn_ti L-asparagine synthetase activity|asparagine synthetase activity|L-aspartate:ammonia ligase (AMP-forming) MetaCyc:ASNSYNA-RXN|RHEA:11372|EC:6.3.1.1 molecular_function owl:Class
GO:0044676 biolink:NamedThing formyl-methanofuran dehydrogenase (molybdenum enzyme) complex A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis. got7fsn_ti jl 2012-08-09T10:56:51Z cellular_component owl:Class
GO:0006578 biolink:NamedThing amino-acid betaine biosynthetic process The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid. got7fsn_ti betaine formation|betaine synthesis|betaine anabolism|betaine biosynthesis|betaine biosynthetic process biological_process owl:Class
GO:0097148 biolink:NamedThing BCL-2 complex A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:51:16Z cellular_component owl:Class
GO:0045574 biolink:NamedThing sterigmatocystin catabolic process The chemical reactions and pathways resulting in the breakdown of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds. got7fsn_ti sterigmatocystin breakdown|sterigmatocystin catabolism|sterigmatocystin degradation biological_process owl:Class
GO:0050873 biolink:NamedThing brown fat cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. got7fsn_ti brown adipocyte differentiation|brown adipocyte cell differentiation biological_process owl:Class
GO:0044321 biolink:NamedThing response to leptin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]. got7fsn_ti response to leptin stimulus jl 2010-07-14T02:31:20Z biological_process owl:Class
GO:0071249 biolink:NamedThing cellular response to nitrate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus. got7fsn_ti mah 2009-12-03T03:02:06Z biological_process owl:Class
GO:0050045 biolink:NamedThing laminaribiose phosphorylase activity Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate. got7fsn_ti 3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity RHEA:16617|EC:2.4.1.31|MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN molecular_function owl:Class
GO:0102505 biolink:NamedThing apigeninidin 5-O-glucosyltransferase activity Catalysis of the reaction: apigeninidin + UDP-alpha-D-glucose <=> apigeninidin 5-O-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-14427 molecular_function owl:Class
GO:0005588 biolink:NamedThing collagen type V trimer A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils. got7fsn_ti cellular_component owl:Class
GO:0098851 biolink:NamedThing double-stranded miRNA binding Binding to double-stranded miRNA. double-stranded miRNA is formed by processing of pre-miRNA stem-loop structures. got7fsn_ti miRNA duplex binding molecular_function owl:Class
GO:0003725 biolink:NamedThing double-stranded RNA binding Binding to double-stranded RNA. got7fsn_ti dsRNA binding molecular_function owl:Class
GO:0036170 biolink:NamedThing filamentous growth of a population of unicellular organisms in response to starvation The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment. got7fsn_ti bf 2012-03-27T03:53:28Z biological_process owl:Class
GO:0003999 biolink:NamedThing adenine phosphoribosyltransferase activity Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. got7fsn_ti adenylic pyrophosphorylase activity|transphosphoribosidase activity|AMP:diphosphate phospho-D-ribosyltransferase activity|AMP pyrophosphorylase activity|adenylate pyrophosphorylase activity|adenosine phosphoribosyltransferase activity|adenine phosphoribosylpyrophosphate transferase activity|AMP-pyrophosphate phosphoribosyltransferase activity|APRT activity|AMP diphosphorylase activity EC:2.4.2.7|Reactome:R-HSA-74213|MetaCyc:ADENPRIBOSYLTRAN-RXN|RHEA:16609 molecular_function owl:Class
GO:0003261 biolink:NamedThing cardiac muscle progenitor cell migration to the midline involved in heart field formation The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart. got7fsn_ti myocardial progenitor cell midline convergence dph 2009-10-15T01:57:55Z biological_process owl:Class
GO:1990585 biolink:NamedThing hydroxyproline O-arabinosyltransferase activity Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline <=> a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+. got7fsn_ti HPAT tb 2014-12-12T18:22:20Z molecular_function owl:Class
GO:0018451 biolink:NamedThing epoxide dehydrogenase activity Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA. got7fsn_ti UM-BBD_reactionID:r0595 molecular_function owl:Class
GO:0050417 biolink:NamedThing glutamin-(asparagin-)ase activity Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate. got7fsn_ti L-ASNase/L-GLNase activity|L-asparagine/L-glutamine amidohydrolase activity|L-glutamine(L-asparagine) amidohydrolase activity|glutaminase-(asparagin-)ase activity|glutaminase-asparaginase activity MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN|EC:3.5.1.38 molecular_function owl:Class
GO:0099006 biolink:NamedThing viral entry via permeabilization of endosomal membrane The entry of a non-enveloped virus into a host eukaryotic cell, following endocytosis, via permeabilization of the endosomal membrane by membrane penetration protein(s) associated with the viral capsid. In some cases, viral membrane-penetration protein require first to be activated to display its membrane penetrating activity. Activation can be due to receptor binding or the acidic pH of the endosomal lumen. got7fsn_ti viral penetration via permeabilization of host membrane VZ:985 biological_process owl:Class
GO:0086039 biolink:NamedThing P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential. got7fsn_ti calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential tb 2011-11-11T03:33:44Z molecular_function owl:Class
GO:0005388 biolink:NamedThing P-type calcium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). got7fsn_ti Ca2+-transporting ATPase activity|Ca(2+)-transporting ATPase activity|ATPase-coupled calcium transmembrane transporter activity|calcium-translocating P-type ATPase activity|calcium transmembrane transporter activity, phosphorylative mechanism|sarco(endo)plasmic reticulum Ca2+-ATPase|calcium transporting ATPase activity|calcium-transporting ATPase activity|ATP-dependent calcium transmembrane transporter activity|calcium efflux ATPase|calcium pump EC:7.2.2.10|Reactome:R-HSA-418365|Reactome:R-HSA-427910|RHEA:18105|Reactome:R-HSA-418309|Reactome:R-HSA-936883|MetaCyc:3.6.3.8-RXN molecular_function owl:Class
GO:1900586 biolink:NamedThing arugosin catabolic process The chemical reactions and pathways resulting in the breakdown of arugosin. got7fsn_ti arugosin degradation|arugosin catabolism|arugosin breakdown di 2012-05-15T06:48:37Z biological_process owl:Class
GO:0075504 biolink:NamedThing macropinosomal membrane permeabilization involved in viral entry into host cell Induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm. got7fsn_ti viral entry into host cell via macropinocytosis followed by macropinosomal membrane permeabilization jl 2010-06-02T02:48:36Z biological_process owl:Class
GO:0102611 biolink:NamedThing (+)-secoisolariciresinol monoglucoside glucosyltransferase activity Catalysis of the reaction: (+)-secoisolariciresinol monoglucoside + UDP-alpha-D-glucose <=> (+)-secoisolariciresinol diglucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-15443 molecular_function owl:Class
GO:0042973 biolink:NamedThing glucan endo-1,3-beta-D-glucosidase activity Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans. got7fsn_ti callase activity|1,3-beta-D-glucan 3-glucanohydrolase activity|kitalase activity|endo-1,3-beta-glucosidase activity|endo-(1->3)-beta-D-glucanase activity|endo-(1,3)-beta-D-glucanase activity|laminaranase activity|(1->3)-beta-glucan 3-glucanohydrolase activity|beta-1,3-glucanase|1,3-beta-D-glucan glucanohydrolase activity|(1->3)-beta-glucan endohydrolase activity|laminarinase activity|endo-1,3-beta-D-glucanase|endo-1,3-beta-glucanase activity|oligo-1,3-glucosidase activity EC:3.2.1.39|MetaCyc:3.2.1.39-RXN molecular_function owl:Class
GO:0031884 biolink:NamedThing type 1 member 1 taste receptor binding Binding to a type 1 member 1 taste receptor. got7fsn_ti type 1 member 1 taste receptor ligand molecular_function owl:Class
GO:0033562 biolink:NamedThing co-transcriptional gene silencing by RNA interference machinery A process in which the RNAi machinery mediates the degradation of nascent transcripts in association with chromatin. got7fsn_ti cotranscriptional gene silencing by RNA interference machinery|RNAi-mediated CTGS|small RNA-mediated cotranscriptional gene silencing|cotranscriptional gene silencing by small RNA|co-transcriptional gene silencing by small RNA biological_process owl:Class
GO:0003863 biolink:NamedThing 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2. got7fsn_ti 3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)|branched-chain keto acid dehydrogenase activity|2-oxoisovalerate (lipoate) dehydrogenase activity|alpha-oxoisocaproate dehydrogenase activity|BCOAD activity|alpha-ketoisocaproic dehydrogenase activity|dehydrogenase, branched chain alpha-keto acid activity|alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity|alpha-ketoacid dehydrogenase activity|branched-chain ketoacid dehydrogenase activity|3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity|alpha-ketoisovalerate dehydrogenase activity|2-oxoisocaproate dehydrogenase activity|branched-chain 2-keto acid dehydrogenase activity|alpha-keto-alpha-methylvalerate dehydrogenase activity|branched-chain alpha-oxo acid dehydrogenase activity|branched chain keto acid dehydrogenase activity|3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity|branched-chain alpha-keto acid dehydrogenase activity|BCKDH activity|branched-chain (-2-oxoacid) dehydrogenase (BCD) activity|branched-chain 2-oxo acid dehydrogenase activity|alpha-ketoisocaproate dehydrogenase activity|dehydrogenase, 2-oxoisovalerate (lipoate) activity https://github.com/geneontology/go-ontology/issues/21144 GO:0003826 MetaCyc:1.2.4.4-RXN|EC:1.2.4.4|RHEA:13457 molecular_function owl:Class
GO:0102962 biolink:NamedThing 4,4'-diapo-zeta-carotene desaturase activity Catalysis of the reaction: all-trans-4,4'-diapo-zeta-carotene + FAD + H+ = 4,4'-diaponeurosporene + FADH2. got7fsn_ti RHEA:31403|MetaCyc:RXN-9305 molecular_function owl:Class
GO:0030345 biolink:NamedThing structural constituent of tooth enamel The action of a molecule that contributes to the structural integrity of tooth enamel. got7fsn_ti molecular_function owl:Class
GO:0030021 biolink:NamedThing extracellular matrix structural constituent conferring compression resistance A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. got7fsn_ti core extracellular matrix|core matrisome Extracellular matrix proteoglycans may be annotated to this term. PMID:8346704 molecular_function owl:Class
GO:0002371 biolink:NamedThing dendritic cell cytokine production Any process that contributes to cytokine production by a dendritic cell. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0033771 biolink:NamedThing licodione synthase activity Catalysis of the reaction: H(+) + liquiritigenin + NADPH + O(2) = H(2)O + licodione + NADP(+). got7fsn_ti (2S)-flavanone 2-hydroxylase activity|liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming) activity MetaCyc:1.14.13.87-RXN|KEGG_REACTION:R07198|EC:1.14.14.140|RHEA:15697 molecular_function owl:Class
GO:0102809 biolink:NamedThing delphinidin 3-O-glucoside 2''-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + delphinidin 3-O-beta-D-glucoside <=> H+ + delphinidin 3-O-sophoroside + UDP. got7fsn_ti MetaCyc:RXN-8178 molecular_function owl:Class
GO:0043786 biolink:NamedThing cinnamate reductase activity Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+. got7fsn_ti EC:1.3.1.- molecular_function owl:Class
GO:0046210 biolink:NamedThing nitric oxide catabolic process The chemical reactions and pathways resulting in the breakdown of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water. got7fsn_ti nitric oxide degradation|nitric oxide catabolism|nitric oxide breakdown biological_process owl:Class
GO:0072491 biolink:NamedThing toluene-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of toluene, methylbenzene (formula C7H8), or any of its derivatives. got7fsn_ti toluene-containing compound catabolism|toluene-containing compound degradation|toluene-containing compound breakdown|toluene and derivative catabolic process mah 2010-12-14T03:51:03Z biological_process owl:Class
GO:0098784 biolink:NamedThing biofilm matrix organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a biofilm matrix. got7fsn_ti biofilm matrix organization and biogenesis biological_process owl:Class
GO:0004153 biolink:NamedThing dihydropterin deaminase activity Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3. got7fsn_ti molecular_function owl:Class
GO:0018590 biolink:NamedThing methylsilanetriol hydroxylase activity Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol. got7fsn_ti UM-BBD_reactionID:r0640 molecular_function owl:Class
GO:0043635 biolink:NamedThing methylnaphthalene catabolic process The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar. got7fsn_ti 1-MN catabolism|1-methylnaphthalene catabolic process|2-MN catabolic process|1-methylnaphthalene catabolism|1-MN catabolic process|2-MN catabolism|2-methylnaphthalene catabolic process|2-methylnaphthalene catabolism biological_process owl:Class
GO:0061787 biolink:NamedThing peptidoglycan cross-bridge peptide endopeptidase activity A peptidoglycan endopeptidase activity that acts on a peptidoglycan cross-bridge. got7fsn_ti lysostaphin activity dph 2016-09-07T16:54:02Z molecular_function owl:Class
GO:0052582 biolink:NamedThing (+)-menthofuran synthase activity Catalysis of the reaction: (R)-pulegone + H(+) + NADPH + O(2) = (R)-menthofuran + 2 H(2)O + NADP(+). got7fsn_ti (+)-pulegone 9-hydroxylase activity|(+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating) activity|menthofuran synthase activity|cytochrome P450 menthofuran synthase activity|(+)-MFS activity ai 2010-08-09T04:47:42Z KEGG_REACTION:R08923|EC:1.14.14.143|RHEA:25658|MetaCyc:1.14.13.104-RXN molecular_function owl:Class
GO:0061218 biolink:NamedThing negative regulation of mesonephros development Any process that decreases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti dph 2010-08-17T03:43:06Z biological_process owl:Class
GO:0060067 biolink:NamedThing cervix development The reproductive developmental process whose specific outcome is the progression of the cervix over time, from its formation to the mature structure. got7fsn_ti Mullerian tract development biological_process owl:Class
GO:0046660 biolink:NamedThing female sex differentiation The establishment of the sex of a female organism by physical differentiation. got7fsn_ti biological_process owl:Class
GO:0047326 biolink:NamedThing inositol tetrakisphosphate 5-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. got7fsn_ti inositol 1,3,4,6-tetrakisphosphate 5-kinase activity|inositol-tetrakisphosphate 5-kinase activity|1D-myo-inositol-tetrakisphosphate 5-kinase activity|ATP:1D-myo-inositol-1,3,4,6-tetrakisphosphate 5-phosphotransferase activity MetaCyc:2.7.1.140-RXN|Reactome:R-HSA-1855228|RHEA:12717|EC:2.7.1.140 molecular_function owl:Class
GO:0030936 biolink:NamedThing transmembrane collagen trimer Any collagen trimer that passes through a lipid bilayer membrane. got7fsn_ti MACIT cellular_component owl:Class
GO:0060069 biolink:NamedThing Wnt signaling pathway, regulating spindle positioning The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle. got7fsn_ti Wnt receptor signaling pathway, regulating spindle positioning|Wnt-activated signaling pathway, regulating spindle positioning|Wnt receptor signalling pathway, regulating spindle positioning|non-canonical Wnt signaling pathway biological_process owl:Class
GO:0072399 biolink:NamedThing response to cytokinesis checkpoint signaling A process that occurs in response to signals generated as a result of cytokinesis checkpoint signaling. got7fsn_ti cytokinesis checkpoint effector process|response to signal involved in cytokinesis checkpoint mah 2010-12-08T03:23:32Z GO:0072420 biological_process owl:Class
GO:0009044 biolink:NamedThing xylan 1,4-beta-xylosidase activity Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini. got7fsn_ti exo-1,4-xylosidase activity|beta-D-xylopyranosidase activity|exo-1,4-beta-xylosidase activity|1,4-beta-D-xylan xylohydrolase activity|beta-xylosidase activity|xylobiase activity|exo-1,4-beta-D-xylosidase activity MetaCyc:3.2.1.37-RXN|EC:3.2.1.37 molecular_function owl:Class
GO:0051218 biolink:NamedThing tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide). got7fsn_ti RESID:AA02376 biological_process owl:Class
GO:0005173 biolink:NamedThing stem cell factor receptor binding Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor. got7fsn_ti SCF|stem cell factor receptor ligand|stem cell factor|KIT binding|SCFR binding molecular_function owl:Class
GO:0050782 biolink:NamedThing galactose uniporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in). got7fsn_ti galactose, glucose uniporter activity molecular_function owl:Class
GO:0047269 biolink:NamedThing poly(ribitol-phosphate) N-acetylglucosaminyltransferase activity Catalysis of the reaction: poly(ribitol phosphate) + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-poly(ribitol phosphate) + UDP. got7fsn_ti uridine diphosphoacetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:poly(ribitol-phosphate) N-acetyl-D-glucosaminyltransferase activity|UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase activity EC:2.4.1.70|MetaCyc:2.4.1.70-RXN|RHEA:21012 molecular_function owl:Class
GO:0103099 biolink:NamedThing UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 5-methylthiopentylhydroximate <=> H+ + 4-methylthiobutyldesulfoglucosinolate + UDP. got7fsn_ti MetaCyc:RXNQT-4324|EC:2.4.1.195 molecular_function owl:Class
GO:0021804 biolink:NamedThing negative regulation of cell adhesion in ventricular zone The process that results in the loss of attachments of a cell in the ventricular zone. got7fsn_ti downregulation of cell adhesion in ventricular zone|down regulation of cell adhesion in ventricular zone|inhibition of cell adhesion in ventricular zone|down-regulation of cell adhesion in ventricular zone biological_process owl:Class
GO:0071116 biolink:NamedThing alpha6-beta1 integrin-CYR61 complex A protein complex that consists of an alpha6-beta1 integrin complex bound to CYR61, a cysteine-rich protein involved in angiogenesis. got7fsn_ti ITGA6-ITGB1-CYR61 complex mah 2009-11-13T02:19:23Z cellular_component owl:Class
GO:0098033 biolink:NamedThing icosahedral viral capsid, neck fiber A fiber attached to the neck at the base of some icosahedral viral capsids. got7fsn_ti bm 2012-07-19T15:07:39Z cellular_component owl:Class
GO:0006541 biolink:NamedThing glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. got7fsn_ti glutamine metabolism biological_process owl:Class
GO:0071191 biolink:NamedThing protocadherin-alpha-v7-protocadherin-gamma-b4 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v7 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdha7-Pcdhgb2 complex mah 2009-11-23T04:30:51Z cellular_component owl:Class
GO:0045112 biolink:NamedThing integrin biosynthetic process The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules. got7fsn_ti integrin anabolism|integrin synthesis|integrin biosynthesis|integrin formation biological_process owl:Class
GO:0060265 biolink:NamedThing positive regulation of respiratory burst involved in inflammatory response Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. got7fsn_ti positive regulation of respiratory burst involved in acute inflammatory response biological_process owl:Class
GO:0102836 biolink:NamedThing 1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity Catalysis of the reaction: 1-18:1-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:1-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8296|EC:1.14.19.23 molecular_function owl:Class
GO:0047985 biolink:NamedThing hydrogen dehydrogenase activity Catalysis of the reaction: H2 + NAD+ = H+ + NADH. got7fsn_ti NAD-linked hydrogenase activity|H(2):NAD(+) oxidoreductase activity|H2:NAD+ oxidoreductase activity|hydrogen:NAD+ oxidoreductase activity|bidirectional hydrogenase activity|hydrogenase activity RHEA:24636|MetaCyc:HYDROGEN-DEHYDROGENASE-RXN|EC:1.12.1.2 molecular_function owl:Class
GO:0003908 biolink:NamedThing methylated-DNA-[protein]-cysteine S-methyltransferase activity Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine. got7fsn_ti methylated-DNA-protein-cysteine S-methyltransferase activity|DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity|6-O-methylguanine-DNA methyltransferase activity|MGMT|O-6-methylguanine-DNA-alkyltransferase activity|O6-alkylguanine-DNA alkyltransferase|DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity MetaCyc:2.1.1.63-RXN|RHEA:24000|EC:2.1.1.63|Reactome:R-HSA-73892 molecular_function owl:Class
GO:0098842 biolink:NamedThing postsynaptic early endosome An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling. got7fsn_ti Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1. cellular_component owl:Class
GO:0003308 biolink:NamedThing negative regulation of Wnt signaling pathway involved in heart development Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time. got7fsn_ti negative regulation of Wnt receptor signaling pathway involved in heart development|negative regulation of Wnt receptor signalling pathway involved in heart development|negative regulation of Wnt-activated signaling pathway involved in heart development dph 2009-10-22T12:36:11Z biological_process owl:Class
GO:0021981 biolink:NamedThing subpallium radially oriented migration The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain. got7fsn_ti biological_process owl:Class
GO:0070947 biolink:NamedThing neutrophil-mediated killing of fungus The directed killing of a fungal cell by a neutrophil. got7fsn_ti neutrophil mediated killing of fungus mah 2009-10-01T02:07:44Z biological_process owl:Class
GO:0097470 biolink:NamedThing ribbon synapse Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm. got7fsn_ti synapsis fasciolaris pr 2013-02-21T07:40:01Z NIF_Subcellular:sao1884931180 cellular_component owl:Class
GO:0042820 biolink:NamedThing vitamin B6 catabolic process The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. got7fsn_ti vitamin B6 degradation|vitamin B6 breakdown|vitamin B6 catabolism biological_process owl:Class
GO:0017060 biolink:NamedThing 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R. got7fsn_ti guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity|Lewis blood group alpha-(1,3/4)-fucosyltransferase activity|Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity|Lewis blood group alpha-(1->3/4)-fucosyltransferase activity|Lewis FT activity|guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity|alpha-(1->4)-L-fucosyltransferase activity|guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity|Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity|blood group Lewis alpha-4-fucosyltransferase activity|alpha(1,4)-L-fucosyltransferase activity|GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity|beta-acetylglucosaminylsaccharide fucosyltransferase activity|(Lea)-dependent (alpha-3/4)-fucosyltransferase activity|Lewis alpha-(1->3/4)-fucosyltransferase activity|alpha-(1,4)-L-fucosyltransferase activity|blood-group substance Le(a)-dependent fucosyltransferase activity|Lewis alpha-(1,3/4)-fucosyltransferase activity|FucT-II activity|GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity|galactoside 3(4)-L-fucosyltransferase activity|alpha-4-L-fucosyltransferase activity|3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha-(1,3/1,4) fucosyltransferase III activity|blood-group substance Lea-dependent fucosyltransferase|(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity Reactome:R-HSA-9603986|MetaCyc:2.4.1.65-RXN|RHEA:23628|Reactome:R-HSA-5693925|EC:2.4.1.65 molecular_function owl:Class
GO:0033792 biolink:NamedThing bile-acid 7alpha-dehydroxylase activity Catalysis of the reactions: deoxycholate + FAD + H2O = cholate + FADH2, and lithocholate + FAD + H2O = chenodeoxycholate + FADH2. got7fsn_ti bile acid 7-dehydroxylase activity|cholate 7alpha-dehydroxylase activity|deoxycholate:FAD oxidoreductase (7alpha-dehydroxylating) activity|deoxycholate:NAD+ oxidoreductase activity|7alpha-dehydroxylase activity MetaCyc:RXN-8658|MetaCyc:RXN-8659|EC:1.17.99.5 molecular_function owl:Class
GO:0102995 biolink:NamedThing angelicin synthase activity Catalysis of the reaction: columbianetin + NADPH + O2 + H+ <=> angelicin + acetone + NADP + 2 H2O. got7fsn_ti MetaCyc:RXN-9689|EC:1.14.14.148|RHEA:27481 molecular_function owl:Class
GO:0047587 biolink:NamedThing 5-alpha-hydroxysteroid dehydratase activity Catalysis of the reaction: 5alpha-ergosta-7,22-diene-3beta,5-diol = ergosterol + H(2)O. got7fsn_ti 5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase (ergosterol-forming)|5alpha-ergosta-7,22-diene-3beta,5-diol 5,6-hydro-lyase activity|5alpha-hydroxysteroid dehydratase activity RHEA:22064|EC:4.2.1.62|KEGG_REACTION:R03675|MetaCyc:5-ALPHA-HYDROXYSTEROID-DEHYDRATASE-RXN molecular_function owl:Class
GO:0018241 biolink:NamedThing protein O-linked glycosylation via hydroxylysine The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine. got7fsn_ti protein amino acid O-linked glycosylation via hydroxylysine RESID:AA0153 biological_process owl:Class
GO:0071758 biolink:NamedThing IgW immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgW isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgW immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti Note that an IgW immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgW is found in fish. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0071978 biolink:NamedThing bacterial-type flagellum-dependent swarming motility Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria. got7fsn_ti bacterial-type flagellar swarming motility|bacterial-type flagellum-mediated cell swarming mah 2010-10-21T03:00:14Z biological_process owl:Class
GO:0050731 biolink:NamedThing positive regulation of peptidyl-tyrosine phosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. got7fsn_ti activation of peptidyl-tyrosine phosphorylation|upregulation of peptidyl-tyrosine phosphorylation|up regulation of peptidyl-tyrosine phosphorylation|stimulation of peptidyl-tyrosine phosphorylation|up-regulation of peptidyl-tyrosine phosphorylation biological_process owl:Class
GO:0090570 biolink:NamedThing RNA polymerase I transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter. got7fsn_ti tb 2014-05-09T13:26:16Z cellular_component owl:Class
GO:0018341 biolink:NamedThing peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine. got7fsn_ti peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process|peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis|peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation|peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism|peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis biological_process owl:Class
GO:0052737 biolink:NamedThing pyruvate dehydrogenase (quinone) activity Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2. got7fsn_ti pyruvate:ubiquinone-8-oxidoreductase activity|pyruvic dehydrogenase activity|pyruvate:ubiquinone oxidoreductase activity|pyruvate dehydrogenase activity EC:1.2.5.1|MetaCyc:RXN-11496|RHEA:27405|KEGG_REACTION:R03145 molecular_function owl:Class
GO:0033427 biolink:NamedThing CAA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CAA codon. got7fsn_ti glutamine tRNA Note that in the standard genetic code, CAA codes for glutamine. molecular_function owl:Class
GO:0002471 biolink:NamedThing monocyte antigen processing and presentation The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti biological_process owl:Class
GO:0010909 biolink:NamedThing positive regulation of heparan sulfate proteoglycan biosynthetic process Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues. got7fsn_ti biological_process owl:Class
GO:0014045 biolink:NamedThing establishment of endothelial blood-brain barrier Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. got7fsn_ti establishment of endothelial blood/brain barrier|establishment of endothelial BBB biological_process owl:Class
GO:0006507 biolink:NamedThing GPI anchor release The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane. got7fsn_ti biological_process owl:Class
GO:0006505 biolink:NamedThing GPI anchor metabolic process The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain. got7fsn_ti glycosylphosphatidylinositol metabolic process|glycosylphosphatidylinositol metabolism|GPI/GSI anchor metabolic process|GPI anchor metabolism|GPI/GSI anchor metabolism GO:0046472 biological_process owl:Class
GO:0016699 biolink:NamedThing oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein. got7fsn_ti oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor GO:0016736|GO:0019110 EC:1.12.7.- molecular_function owl:Class
GO:0016138 biolink:NamedThing glycoside biosynthetic process The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. got7fsn_ti O-glycoside formation|glycoside anabolism|O-glycoside biosynthesis|glycoside biosynthesis|glycoside formation|O-glycoside biosynthetic process|glycoside synthesis|O-glycoside synthesis|O-glycoside anabolism GO:0016141 biological_process owl:Class
GO:0045242 biolink:NamedThing isocitrate dehydrogenase complex (NAD+) Complex that possesses isocitrate dehydrogenase (NAD+) activity. got7fsn_ti cellular_component owl:Class
GO:0008154 biolink:NamedThing actin polymerization or depolymerization Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. got7fsn_ti biological_process owl:Class
GO:0140327 biolink:NamedThing flippase activity Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. got7fsn_ti flippase activity (exoplasmic to cytosolic leaftlet) Nomenclature note. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases). Scramblases are ATP-independent, non-selective, inducing non-specific transbilayer movements across the membrane. The direction of the translocation should be taken into account for annotation (from the exoplasmic to the cytosolic leaftlet of a membrane). pg 2019-04-29T12:51:21Z molecular_function owl:Class
GO:0140575 biolink:NamedThing transmembrane monodehydroascorbate reductase activity Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20602 pg 2021-01-07T16:20:04Z RHEA:66524 molecular_function owl:Class
GO:0002162 biolink:NamedThing dystroglycan binding Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal). got7fsn_ti alpha-dystroglycan binding|beta-dystroglycan binding hjd 2010-02-22T02:17:58Z GO:0002163|GO:0002166 molecular_function owl:Class
GO:0009962 biolink:NamedThing regulation of flavonoid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. got7fsn_ti regulation of flavonoid anabolism|regulation of flavonoid biosynthesis|regulation of flavonoid synthesis|regulation of flavonoid formation biological_process owl:Class
GO:0035782 biolink:NamedThing mature natural killer cell chemotaxis The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules. got7fsn_ti activated natural killer cell chemotaxis bf 2011-04-04T11:23:13Z biological_process owl:Class
GO:0102888 biolink:NamedThing delta-cuprenene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> delta-cuprenene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8431 molecular_function owl:Class
GO:1905862 biolink:NamedThing ferroxidase complex A protein complex which is capable of ferroxidase activity. got7fsn_ti An example of this is FET3 in Saccharomyces cerevisiae (P38993) in PMID:16522632 (inferred from direct assay). bhm 2017-01-25T10:01:39Z cellular_component owl:Class
GO:0017054 biolink:NamedThing negative cofactor 2 complex A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini. got7fsn_ti cellular_component owl:Class
GO:0004650 biolink:NamedThing polygalacturonase activity Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans. got7fsn_ti endo-D-galacturonase activity|endo-polygalacturonase activity|endogalacturonase activity|pectinase activity|pectin polygalacturonase activity|pectolase activity|pectin hydrolase activity|pectin depolymerase activity|poly(1,4-alpha-D-galacturonide) glycanohydrolase activity|poly-alpha-1,4-galacturonide glycanohydrolase activity|endopolygalacturonase activity EC:3.2.1.15|MetaCyc:RXN-2103 molecular_function owl:Class
GO:0043179 biolink:NamedThing rhythmic excitation Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit. got7fsn_ti biological_process owl:Class
GO:0002053 biolink:NamedThing positive regulation of mesenchymal cell proliferation The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells. got7fsn_ti activation of mesenchymal cell proliferation|up-regulation of mesenchymal cell proliferation|stimulation of mesenchymal cell proliferation|up regulation of mesenchymal cell proliferation|upregulation of mesenchymal cell proliferation biological_process owl:Class
GO:0034680 biolink:NamedThing integrin alpha10-beta1 complex An integrin complex that comprises one alpha10 subunit and one beta1 subunit. got7fsn_ti ITGA10-ITGB1 complex|alpha10-beta1 integrin complex cellular_component owl:Class
GO:0022848 biolink:NamedThing acetylcholine-gated cation-selective channel activity Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. got7fsn_ti nAChR|acetylcholine-gated cation channel activity|nicotinic acetylcholine-activated cation-selective channel activity|acetylcholine-activated cation-selective channel activity|ionotropic acetylcholine receptor activity|nicotinergic acetylcholine receptor activity GO:0016904|GO:0004889 molecular_function owl:Class
GO:0030942 biolink:NamedThing endoplasmic reticulum signal peptide binding Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. got7fsn_ti ER signal peptide binding molecular_function owl:Class
GO:0005159 biolink:NamedThing insulin-like growth factor receptor binding Binding to an insulin-like growth factor receptor. got7fsn_ti IGF receptor binding|insulin-like growth factor receptor ligand|insulin-like growth factor GO:0005067 molecular_function owl:Class
GO:0002174 biolink:NamedThing mammary stem cell proliferation The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ. got7fsn_ti hjd 2010-09-14T01:19:45Z biological_process owl:Class
GO:0044024 biolink:NamedThing histone kinase activity (H2A-S1 specific) Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A. got7fsn_ti histone serine kinase activity (H2A-S1 specific)|histone-serine kinase activity (H2A-S1 specific) molecular_function owl:Class
GO:0046225 biolink:NamedThing bacteriocin catabolic process The chemical reactions and pathways resulting in the breakdown of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. got7fsn_ti bacteriocin catabolism|bacteriocin degradation|bacteriocin breakdown biological_process owl:Class
GO:0140068 biolink:NamedThing histone crotonyltransferase activity Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone. got7fsn_ti pg 2017-07-20T16:55:16Z molecular_function owl:Class
GO:0102290 biolink:NamedThing beta-amyrin monooxygenase activity Catalysis of the reaction: beta-amyrin + O2 + NADPH + H+ <=> 11alpha-hydroxy-beta-amyrin + H2O + NADP. got7fsn_ti EC:1.14.14.152|MetaCyc:RXN-12681|RHEA:31715 molecular_function owl:Class
GO:0004531 biolink:NamedThing deoxyribonuclease II activity Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products. got7fsn_ti acid deoxyribonuclease activity|acid DNase activity|DNase II activity|pancreatic DNase II|deoxyribonucleate 3'-nucleotidohydrolase activity|lysosomal DNase II activity MetaCyc:3.1.22.1-RXN|EC:3.1.22.1 molecular_function owl:Class
GO:0016889 biolink:NamedThing endodeoxyribonuclease activity, producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. got7fsn_ti endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters EC:3.1.22.- molecular_function owl:Class
GO:0060295 biolink:NamedThing regulation of cilium movement involved in cell motility Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility. got7fsn_ti biological_process owl:Class
GO:0051521 biolink:NamedThing termination of monopolar cell growth Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell. got7fsn_ti biological_process owl:Class
GO:0051514 biolink:NamedThing negative regulation of monopolar cell growth Any process that stops, prevents, or reduces the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell. got7fsn_ti inhibition of monopolar cell growth|down regulation of monopolar cell growth|down-regulation of monopolar cell growth|downregulation of monopolar cell growth biological_process owl:Class
GO:0075032 biolink:NamedThing negative regulation of formation of symbiont germ tube hook structure for appressorium development Any process that stops, prevents, or reduces the frequency, rate or extent of symbiont germ tube hook structure formation. got7fsn_ti negative regulation of germ tube tip of symbiont on or near the exterior of host|negative regulation of formation of symbiont germ tube hook structure on or near host|negative regulation of symbiont germ tube hook structure formation on or near host biological_process owl:Class
GO:0004731 biolink:NamedThing purine-nucleoside phosphorylase activity Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. got7fsn_ti PNPase activity|purine deoxyribonucleoside phosphorylase activity|purine ribonucleoside phosphorylase activity|purine deoxynucleoside phosphorylase activity|PUNPI|PUNPII|purine-nucleoside:phosphate ribosyltransferase activity|inosine-guanosine phosphorylase activity|inosine phosphorylase activity|purine nucleoside phosphorylase activity Reactome:R-HSA-74249|RHEA:19805|EC:2.4.2.1|Reactome:R-HSA-112034|MetaCyc:PNP-RXN|Reactome:R-HSA-74242|Reactome:R-HSA-112033 molecular_function owl:Class
GO:0102951 biolink:NamedThing indole-3-acetyl-phenylalanine synthetase activity Catalysis of the reaction: indole-3-acetate + L-phenylalanine + ATP = H+ + indole-3-acetyl-phenylalanine + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-9084 molecular_function owl:Class
GO:0032094 biolink:NamedThing response to food Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat. got7fsn_ti biological_process owl:Class
GO:0071762 biolink:NamedThing heavy chain immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgNAR isotype held together by disulfide bonds and lacking immunoglobulin light chains. got7fsn_ti HCab|IgNAR immunoglobulin complex|IgNAR antibody|Ig NAR immunoglobulin complex Note that a heavy chain immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgNAR is found in serum of cartilaginous fish as a heavy chain dimer without immunoglobulin light chains. Note that HCab is found in camels as a heavy chain dimer without immunoglobulin light chains. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0021726 biolink:NamedThing lateral reticular nucleus development The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0032001 biolink:NamedThing 1,4-alpha-glucan 6-alpha-glucosyltransferase activity Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan. got7fsn_ti D-glucosyltransferase|T-enzyme|1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity|1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity|oligoglucan-branching glycosyltransferase activity EC:2.4.1.24|MetaCyc:2.4.1.24-RXN molecular_function owl:Class
GO:0018588 biolink:NamedThing tri-n-butyltin dioxygenase activity Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin. got7fsn_ti TBT dioxygenase activity UM-BBD_reactionID:r0643 molecular_function owl:Class
GO:0031486 biolink:NamedThing myosin XVI complex A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat. got7fsn_ti cellular_component owl:Class
GO:0052665 biolink:NamedThing tRNA (uracil-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methyluracil. got7fsn_ti tRNA uracil-2'-O-methyltransferase activity|S-adenosyl-L-methionine:tRNA (uracil-2'-O-)-methyltransferase activity|tRNA (uracil 2')-methyltransferase activity|S-adenosyl-L-methionine:tRNA uracil-2'-O-methyltransferase activity|transfer ribonucleate uracil 2'-methyltransferase activity|tRNA uracil 2'-methyltransferase activity ai 2010-10-11T01:05:35Z RHEA:43100|Reactome:R-HSA-6788707|MetaCyc:RXN0-5143|EC:2.1.1.34 molecular_function owl:Class
GO:0031531 biolink:NamedThing thyrotropin-releasing hormone receptor binding Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary. got7fsn_ti thyrotropin releasing hormone receptor binding|thyrotropin-releasing hormone receptor ligand GO:0031888 molecular_function owl:Class
GO:0052760 biolink:NamedThing coenzyme F420-dependent 2,4-dinitrophenol reductase activity Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction. got7fsn_ti coenzyme F420-dependent 2,4-dinitrophenol hydride transferase activity|DNP reductase activity ai 2011-09-28T02:47:31Z EC:1.3.99.-|UM-BBD_reactionID:r1071 molecular_function owl:Class
GO:0047854 biolink:NamedThing diguanidinobutanase activity Catalysis of the reaction: 1,4-diguanidinobutane + H(2)O = agmatine + urea. got7fsn_ti 1,4-diguanidinobutane amidinohydrolase activity RHEA:13597|MetaCyc:DIGUANIDINOBUTANASE-RXN|EC:3.5.3.20|KEGG_REACTION:R01418 molecular_function owl:Class
GO:0106333 biolink:NamedThing subcortical maternal complex Comprised of at least NLRP5, OOEP, TLE6, and KHDC3/KHDC3L with evidence of additional SCMC-associated proteins that interact with one or multiple members of the core complex. got7fsn_ti SCMC hjd 2020-10-14T13:49:57Z cellular_component owl:Class
GO:0010168 biolink:NamedThing ER body A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species. got7fsn_ti endoplasmic reticulum body cellular_component owl:Class
GO:0032032 biolink:NamedThing myosin I tail binding Binding to the tail region of a myosin I heavy chain. got7fsn_ti molecular_function owl:Class
GO:0061364 biolink:NamedThing apoptotic process involved in luteolysis The apoptotic process that contributes to luteolysis. got7fsn_ti apoptosis involved in luteolysis|structural luteolysis dph 2010-10-14T03:18:49Z biological_process owl:Class
GO:1902742 biolink:NamedThing apoptotic process involved in development Any apoptotic process that is involved in anatomical structure development. got7fsn_ti apoptotic process involved in anatomical structure development|apoptosis involved in anatomical structure development|activation of apoptosis involved in development of an anatomical structure|apoptotic program involved in development of an anatomical structure|type I programmed cell death involved in development of an anatomical structure|activation of apoptosis involved in anatomical structure development|commitment to apoptosis involved in development of an anatomical structure|apoptotic cell death involved in development of an anatomical structure|apoptotic cell death involved in anatomical structure development|programmed cell death by apoptosis involved in anatomical structure development|programmed cell death by apoptosis involved in development of an anatomical structure|type I programmed cell death involved in anatomical structure development|signaling (initiator) caspase activity involved in development of an anatomical structure|apoptotic program involved in anatomical structure development|induction of apoptosis involved in development of an anatomical structure|apoptotic programmed cell death involved in development of an anatomical structure|apoptosis signaling involved in development of an anatomical structure|apoptosis activator activity involved in anatomical structure development|apoptosis activator activity involved in development of an anatomical structure|commitment to apoptosis involved in anatomical structure development|induction of apoptosis by p53 involved in development of an anatomical structure|induction of apoptosis by p53 involved in anatomical structure development|apoptosis signaling involved in anatomical structure development|apoptosis involved in development of an anatomical structure|induction of apoptosis involved in anatomical structure development|apoptotic process involved in development of an anatomical structure|signaling (initiator) caspase activity involved in anatomical structure development|apoptotic programmed cell death involved in anatomical structure development pr 2014-02-28T13:09:43Z biological_process owl:Class
GO:1990183 biolink:NamedThing lymphatic vascular process in circulatory system A circulatory process that occurs at the level of the lymphatic vasculature. got7fsn_ti sl 2013-09-10T22:26:40Z biological_process owl:Class
GO:0008107 biolink:NamedThing galactoside 2-alpha-L-fucosyltransferase activity Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. got7fsn_ti guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity|secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity|secretor-type beta-galactoside alpha1->2 fucosyltransferase activity|guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity|guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity|alpha-2-fucosyltransferase activity|alpha(1,2)-L-fucosyltransferase activity|alpha-(1->2)-L-fucosyltransferase activity|guanosine diphosphofucose-lactose fucosyltransferase activity|H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity|GDP fucose-lactose fucosyltransferase activity|galactoside 2-L-fucosyltransferase activity|blood-group substance H-dependent fucosyltransferase activity|blood group H alpha-2-fucosyltransferase activity|GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity|beta-galactoside alpha1->2 fucosyltransferase activity|H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity|beta-galactoside alpha-1->2 fucosyltransferase activity|GDP-L-fucose:lactose fucosyltransferase activity|guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity|guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity|alpha-2-L-fucosyltransferase activity|guanosine diphospho-L-fucose-lactose fucosyltransferase activity|guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity Reactome:R-HSA-9603983|Reactome:R-HSA-9603982|MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN|RHEA:50664|Reactome:R-HSA-9036987|EC:2.4.1.69 molecular_function owl:Class
GO:0042206 biolink:NamedThing halogenated hydrocarbon catabolic process The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. got7fsn_ti halogenated hydrocarbon breakdown|halogenated hydrocarbon degradation|halogenated hydrocarbon catabolism biological_process owl:Class
GO:0102613 biolink:NamedThing trimethyluric acid monooxygenase activity Catalysis of the reaction: 1,3,7-trimethyluric acid + O2 + NADH + 3 H+ <=> 1,3,7-trimethyl-5-hydroxyisourate + NAD + H2O. got7fsn_ti RHEA:48992|MetaCyc:RXN-15454 molecular_function owl:Class
GO:0039683 biolink:NamedThing rolling circle double-stranded viral DNA replication A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome. got7fsn_ti dsDNA rolling circle replication bf 2013-10-17T14:15:04Z VZ:2676 biological_process owl:Class
GO:0047634 biolink:NamedThing agmatine N4-coumaroyltransferase activity Catalysis of the reaction: 4-coumaroyl-CoA + agmatine = N-(4-guanidiniumylbutyl)-4-hydroxycinnamamide + CoA + H(+). got7fsn_ti 4-coumaroyl-CoA:agmatine N4-coumaroyltransferase activity|agmatine coumaroyltransferase activity|p-coumaroyl-CoA-agmatine N-p-coumaroyltransferase activity|4-coumaroyl-CoA:agmatine 4-N-coumaroyltransferase activity RHEA:13405|EC:2.3.1.64|MetaCyc:AGMATINE-N4-COUMAROYLTRANSFERASE-RXN|KEGG_REACTION:R01617 molecular_function owl:Class
GO:0060139 biolink:NamedThing positive regulation of apoptotic process by virus Any viral process that activates or increases the frequency, rate or extent of cell death by apoptotic process. got7fsn_ti positive regulation of apoptosis by virus biological_process owl:Class
GO:0008456 biolink:NamedThing alpha-N-acetylgalactosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides. got7fsn_ti N-acetyl-alpha-galactosaminidase activity|N-acetyl-alpha-D-galactosaminidase activity|alpha-NAGA activity|alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity|alpha-galactosidase B activity|alpha-acetylgalactosaminidase activity MetaCyc:3.2.1.49-RXN|EC:3.2.1.49|RHEA:15085 molecular_function owl:Class
GO:0003925 biolink:NamedThing G protein activity A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). got7fsn_ti signaling G protein activity|large G-protein GTPase activity|large G-protein activity|small monomeric G protein activity|heterotrimeric G-protein GTPase activity|small monomeric GTPase activity https://github.com/geneontology/go-ontology/issues/19082 GO:0003927 EC:3.6.5.1|MetaCyc:3.6.1.47-RXN|MetaCyc:3.6.1.46-RXN|EC:3.6.5.2 molecular_function owl:Class
GO:0102292 biolink:NamedThing 30-hydroxy-beta-amyrin 11-hydroxylase activity Catalysis of the reaction: 30-hydroxy-beta-amyrin + O2 + NADPH + H+ <=> 11alpha,30-dihydroxy-beta-amyrin + H2O + NADP. got7fsn_ti MetaCyc:RXN-12683 molecular_function owl:Class
GO:0038039 biolink:NamedThing G protein-coupled receptor heterodimeric complex A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR. got7fsn_ti GPCR heterodimer|G-protein coupled receptor heterodimer|G-protein coupled receptor heterodimeric complex bf 2011-11-02T04:44:20Z cellular_component owl:Class
GO:0071045 biolink:NamedThing nuclear histone mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus. got7fsn_ti krc 2009-07-30T09:52:44Z biological_process owl:Class
GO:0120299 biolink:NamedThing peptide histaminyltransferase activity Catalysis of the reaction: histamine + L-glutaminyl-[protein] = 5-histaminyl-L-glutamyl-[protein]. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20685 krc 2021-01-19T03:23:48Z RHEA:66564 molecular_function owl:Class
GO:0050689 biolink:NamedThing negative regulation of defense response to virus by host Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti downregulation of antiviral response by host|negative regulation by host of antiviral response|down-regulation of antiviral response by host|negative regulation of antiviral response by host|down regulation of antiviral response by host|inhibition of antiviral response by host biological_process owl:Class
GO:0031553 biolink:NamedThing positive regulation of brain-derived neurotrophic factor-activated receptor activity Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity. got7fsn_ti upregulation of brain-derived neurotrophic factor receptor activity|up-regulation of brain-derived neurotrophic factor receptor activity|up regulation of brain-derived neurotrophic factor receptor activity|stimulation of brain-derived neurotrophic factor receptor activity|positive regulation of brain-derived neurotrophic factor receptor activity|positive regulation of BDNF receptor activity|activation of brain-derived neurotrophic factor receptor activity biological_process owl:Class
GO:0031550 biolink:NamedThing positive regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. got7fsn_ti positive regulation of BDNF receptor signalling pathway|upregulation of brain-derived neurotrophic factor receptor signaling pathway|stimulation of brain-derived neurotrophic factor receptor signaling pathway|positive regulation of brain-derived neurotrophic factor receptor signalling pathway|activation of brain-derived neurotrophic factor receptor signaling pathway|positive regulation of BDNF receptor signaling pathway|up regulation of brain-derived neurotrophic factor receptor signaling pathway|up-regulation of brain-derived neurotrophic factor receptor signaling pathway biological_process owl:Class
GO:0021851 biolink:NamedThing neuroblast division in dorsal lateral ganglionic eminence The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb. got7fsn_ti biological_process owl:Class
GO:0021848 biolink:NamedThing neuroblast division in subpallium The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially. got7fsn_ti neuroblast division in the ventral telencephalon biological_process owl:Class
GO:0046222 biolink:NamedThing aflatoxin metabolic process The chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450. got7fsn_ti aflatoxin B2 metabolic process|aflatoxin B1 metabolism|aflatoxin B metabolic process|aflatoxin metabolism|aflatoxin B2 metabolism|aflatoxin B1 metabolic process https://github.com/geneontology/go-ontology/issues/18291 GO:0043390|GO:0043391|GO:0043389 biological_process owl:Class
GO:0047931 biolink:NamedThing glucosamine kinase activity Catalysis of the reaction: ATP + D-glucosamine = ADP + D-glucosamine phosphate. got7fsn_ti ATP:2-amino-2-deoxy-D-glucose-6-phosphotransferase activity|aminodeoxyglucose kinase activity|glucosamine kinase (phosphorylating)|ATP:D-glucosamine phosphotransferase activity EC:2.7.1.8|MetaCyc:GLUCOSAMINE-KINASE-RXN|RHEA:10948 molecular_function owl:Class
GO:0031648 biolink:NamedThing protein destabilization Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation. got7fsn_ti protein destabilisation|negative regulation of protein stability biological_process owl:Class
GO:0044205 biolink:NamedThing 'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen. got7fsn_ti 'de novo' UMP biosynthesis jl 2009-10-21T11:27:31Z biological_process owl:Class
GO:0060499 biolink:NamedThing fibroblast growth factor receptor signaling pathway involved in lung induction The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands resulting in the formation of the lung bud along the lateral-esophageal sulcus. got7fsn_ti fibroblast growth factor receptor signalling pathway involved in lung induction biological_process owl:Class
GO:0035096 biolink:NamedThing larval midgut cell programmed cell death The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ. got7fsn_ti larval midgut cell death|programmed cell death of larval midgut cells biological_process owl:Class
GO:0071885 biolink:NamedThing N-terminal protein N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the alpha-amino group of the N-terminal amino or imino acid residue of a protein substrate. For example, yeast Tae1p and mammalian family member METTL11A preferentially modify the N-terminal residue of substrates with the N-terminal sequence X-Pro-Lys, where X can be Pro, Ala, or Ser. got7fsn_ti X-Pro-Lys N-terminal methyltransferase mah 2010-09-13T04:53:57Z molecular_function owl:Class
GO:0005905 biolink:NamedThing clathrin-coated pit A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. got7fsn_ti coated pit NIF_Subcellular:sao1969557946 cellular_component owl:Class
GO:0019145 biolink:NamedThing aminobutyraldehyde dehydrogenase activity Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+. got7fsn_ti 4-aminobutanal dehydrogenase activity|ABAL dehydrogenase activity|4-aminobutanal:NAD+ 1-oxidoreductase activity|4-aminobutyraldehyde dehydrogenase activity|gamma-aminobutyraldehyde dehydroganase activity EC:1.2.1.19|RHEA:19105|MetaCyc:AMINOBUTDEHYDROG-RXN molecular_function owl:Class
GO:0062129 biolink:NamedThing chitin-based extracellular matrix Any constituent part of a chitin-based noncellular, hardened, or membranous extracellular matrix secreted from the apical surface of an epithelial sheet. got7fsn_ti chitin-based ECM dph 2019-06-13T12:57:13Z cellular_component owl:Class
GO:0010918 biolink:NamedThing positive regulation of mitochondrial membrane potential Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. got7fsn_ti elevation of mitochondrial membrane potential biological_process owl:Class
GO:0034653 biolink:NamedThing retinoic acid catabolic process The chemical reactions and pathways resulting in the breakdown of retinoic acid, one of the three components that makes up vitamin A. got7fsn_ti vitamin A1 acid catabolic process|retinoic acid catabolism|retinoic acid degradation|retinoic acid breakdown biological_process owl:Class
GO:0060679 biolink:NamedThing trifid subdivision of terminal units involved in ureteric bud branching The process in which a ureteric bud splits into three units at its end. got7fsn_ti dph 2009-06-02T02:37:42Z biological_process owl:Class
GO:0003960 biolink:NamedThing NADPH:quinone reductase activity Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone. got7fsn_ti zeta-crystallin activity|NADPH:quinone oxidoreductase activity|quinone oxidoreductase activity EC:1.6.5.5|RHEA:14269|MetaCyc:QOR-RXN|Reactome:R-HSA-6799722 molecular_function owl:Class
GO:0043769 biolink:NamedThing Tpg-containing telomere binding complex A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species. got7fsn_ti telomere complex cellular_component owl:Class
GO:0004040 biolink:NamedThing amidase activity Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. got7fsn_ti acetamidase activity|acylamidase activity|fatty acylamidase activity|acylamide amidohydrolase activity|acylase activity|N-acetylaminohydrolase activity|amidohydrolase activity UM-BBD_enzymeID:e0068|MetaCyc:AMIDASE-RXN|RHEA:12020|EC:3.5.1.4 molecular_function owl:Class
GO:0050975 biolink:NamedThing sensory perception of touch The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach). got7fsn_ti tactile sense|taction|tactition|perception of touch Wikipedia:Touch biological_process owl:Class
GO:0071633 biolink:NamedThing dihydroceramidase activity Catalysis of the reaction: a dihydroceramide + H2O = a fatty acid + dihydrosphingosine. got7fsn_ti mah 2010-02-11T04:24:12Z molecular_function owl:Class
GO:0047982 biolink:NamedThing homocysteine desulfhydrase activity Catalysis of the reaction: L-homocysteine + H2O = sulfide + NH3 + 2-oxobutanoate. got7fsn_ti L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)|L-homocysteine hydrogen-sulfide-lyase (deaminating)|homocysteine desulfurase activity Reactome:R-HSA-1614631|MetaCyc:HOMOCYSTEINE-DESULFHYDRASE-RXN|RHEA:14501|EC:4.4.1.2 molecular_function owl:Class
GO:0051086 biolink:NamedThing chaperone mediated protein folding independent of cofactor The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release. got7fsn_ti chaperone cofactor-independent protein folding biological_process owl:Class
GO:0001514 biolink:NamedThing selenocysteine incorporation The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine. got7fsn_ti RESID:AA0022 biological_process owl:Class
GO:0110087 biolink:NamedThing suppression by virus of host protease activator activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protease activator activity. got7fsn_ti kmv 2018-02-12T20:17:29Z biological_process owl:Class
GO:0032530 biolink:NamedThing regulation of microvillus organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus. got7fsn_ti regulation of microvillus organization and biogenesis|regulation of microvillus organisation biological_process owl:Class
GO:0035314 biolink:NamedThing scab formation Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection. got7fsn_ti biological_process owl:Class
GO:0009673 biolink:NamedThing low-affinity phosphate transmembrane transporter activity Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low affinity phosphate transmembrane transporter activity molecular_function owl:Class
GO:0090537 biolink:NamedThing CERF complex An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters. got7fsn_ti tb 2013-02-11T14:07:14Z cellular_component owl:Class
GO:0008768 biolink:NamedThing UDP-sugar diphosphatase activity Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate. got7fsn_ti UDP-sugar sugarphosphohydrolase activity|UDP-sugar pyrophosphatase activity|nucleosidediphosphate-sugar pyrophosphatase activity|nucleosidediphosphate-sugar diphosphatase activity|UDP-sugar hydrolase activity Reactome:R-HSA-6810464|MetaCyc:UDPSUGARHYDRO-RXN|EC:3.6.1.45 molecular_function owl:Class
GO:0098981 biolink:NamedThing cholinergic synapse A synapse that uses acetylcholine as a neurotransmitter. got7fsn_ti cellular_component owl:Class
GO:0003721 biolink:NamedThing telomerase RNA reverse transcriptase activity Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template. got7fsn_ti telomerase, catalyst molecular_function owl:Class
GO:0062046 biolink:NamedThing dehydropipecolic acid reductase Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+. got7fsn_ti dph 2018-05-11T12:16:00Z molecular_function owl:Class
GO:0006316 biolink:NamedThing movement of group I intron Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction. got7fsn_ti biological_process owl:Class
GO:0070066 biolink:NamedThing cellubrevin-VAMP4-endobrevin-syntaxin-6 complex A SNARE complex that contains cellubrevin (VAMP3), VAMP4, endobrevin (VAMP8), and syntaxin 6 (or orthologs thereof). got7fsn_ti SNARE complex (Vamp3, Vamp4, Vam8, Stx6)|Vamp3-Vamp4-Vam8-Stx6 complex cellular_component owl:Class
GO:0010597 biolink:NamedThing green leaf volatile biosynthetic process The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid. got7fsn_ti biological_process owl:Class
GO:0019372 biolink:NamedThing lipoxygenase pathway The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. got7fsn_ti biological_process owl:Class
GO:0050560 biolink:NamedThing aspartate-tRNA(Asn) ligase activity Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP. got7fsn_ti nondiscriminating aspartyl-tRNA synthetase activity|L-aspartate:tRNAAsx ligase (AMP-forming)|aspartate-tRNAAsn ligase activity MetaCyc:6.1.1.23-RXN|RHEA:18349|EC:6.1.1.23 molecular_function owl:Class
GO:0003746 biolink:NamedThing translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome. got7fsn_ti GO:0008182|GO:0008183 Reactome:R-HSA-192704|Reactome:R-HSA-192841 molecular_function owl:Class
GO:0004143 biolink:NamedThing diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate. got7fsn_ti diglyceride kinase activity|arachidonoyl-specific diacylglycerol kinase activity|1,2-diacylglycerol kinase activity|sn-1,2-diacylglycerol kinase activity|DG kinase activity|CTP:diacylglycerol kinase activity|DGK activity|diacylglycerol:ATP kinase activity|ATP:diacylglycerol phosphotransferase activity|ATP:1,2-diacylglycerol 3-phosphotransferase activity|1,2-diacylglycerol kinase (phosphorylating) RHEA:10272|MetaCyc:DIACYLGLYKIN-RXN|EC:2.7.1.107|Reactome:R-HSA-426240 molecular_function owl:Class
GO:0038096 biolink:NamedThing Fc-gamma receptor signaling pathway involved in phagocytosis An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. got7fsn_ti Fc-gamma receptor signalling pathway involved in phagocytosis|Fc gamma receptor-dependent phagocytosis|IgG-mediated phagocytosis|Fcgamma receptor-mediated phagocytosis bf 2012-02-16T05:26:25Z biological_process owl:Class
GO:0002749 biolink:NamedThing antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR). got7fsn_ti antigen processing and presentation initiated by TLR mediated phagocytosis of antigen biological_process owl:Class
GO:0002747 biolink:NamedThing antigen processing and presentation following phagocytosis Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis. got7fsn_ti biological_process owl:Class
GO:0002470 biolink:NamedThing plasmacytoid dendritic cell antigen processing and presentation The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. got7fsn_ti biological_process owl:Class
GO:0004487 biolink:NamedThing methylenetetrahydrofolate dehydrogenase (NAD+) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH. got7fsn_ti 5,10-methylenetetrahydrofolate dehydrogenase activity|5,10-methylenetetrahydrofolate:NAD+ oxidoreductase KEGG_REACTION:R01218|Reactome:R-HSA-6801462|MetaCyc:1.5.1.15-RXN|RHEA:22892|EC:1.5.1.15 molecular_function owl:Class
GO:1902298 biolink:NamedThing cell cycle DNA replication maintenance of fidelity Any maintenance of fidelity that is involved in cell cycle DNA replication. got7fsn_ti maintenance of fidelity involved in cell cycle DNA replication|maintenance of fidelity during DNA-dependent DNA replication involved in cell cycle DNA replication jl 2013-07-10T11:47:19Z biological_process owl:Class
GO:0030431 biolink:NamedThing sleep Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain. got7fsn_ti diapause|lethargus|dormancy Wikipedia:Sleep biological_process owl:Class
GO:0030275 biolink:NamedThing LRR domain binding Binding to a LRR domain (leucine rich repeats) of a protein. got7fsn_ti molecular_function owl:Class
GO:0048085 biolink:NamedThing adult chitin-containing cuticle pigmentation Establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster. got7fsn_ti adult cuticle pigmentation GO:0048068 biological_process owl:Class
GO:0140262 biolink:NamedThing mRNA cap binding complex binding Binding to a mRNA cap binding complex. got7fsn_ti pg 2018-09-12T12:56:16Z molecular_function owl:Class
GO:0032809 biolink:NamedThing neuronal cell body membrane The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. got7fsn_ti neuronal cell soma membrane|neuron cell body membrane cellular_component owl:Class
GO:0030020 biolink:NamedThing extracellular matrix structural constituent conferring tensile strength A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress. got7fsn_ti core matrisome|core extracellular matrix Extracellular matrix collagen proteins may be annotated to this term. PMID:29632050, PMID:24443019 molecular_function owl:Class
GO:0018040 biolink:NamedThing C-terminal peptidyl-glutamic acid amidation The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0087 biological_process owl:Class
GO:0015693 biolink:NamedThing magnesium ion transport The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti magnesium transport biological_process owl:Class
GO:0004476 biolink:NamedThing mannose-6-phosphate isomerase activity Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. got7fsn_ti phosphohexoisomerase activity|D-mannose-6-phosphate aldose-ketose-isomerase activity|D-mannose-6-phosphate ketol-isomerase activity|phosphohexomutase activity|phosphomannoisomerase activity|phosphomannose isomerase activity|mannose phosphate isomerase activity EC:5.3.1.8|MetaCyc:MANNPISOM-RXN|RHEA:12356|Reactome:R-HSA-3781832|Reactome:R-HSA-532549 molecular_function owl:Class
GO:0106015 biolink:NamedThing negative regulation of inflammatory response to wounding Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding. got7fsn_ti hjd 2017-04-28T20:09:46Z biological_process owl:Class
GO:0106014 biolink:NamedThing regulation of inflammatory response to wounding Any process that modulates the frequency, rate or extent of the inflammatory response to wounding. got7fsn_ti hjd 2017-04-28T20:03:14Z biological_process owl:Class
GO:0021672 biolink:NamedThing rhombomere 7 structural organization The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti rhombomere 7 structural organisation biological_process owl:Class
GO:0031959 biolink:NamedThing mineralocorticoid receptor signaling pathway Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor. got7fsn_ti mineralocorticoid receptor signalling pathway biological_process owl:Class
GO:0140432 biolink:NamedThing 5'-hydroxyl dinucleotide hydrolase Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18881 pg 2020-02-19T05:50:35Z molecular_function owl:Class
GO:0010846 biolink:NamedThing activation of reciprocal meiotic recombination Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. got7fsn_ti activation of meiotic recombination biological_process owl:Class
GO:0042564 biolink:NamedThing NLS-dependent protein nuclear import complex A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore. got7fsn_ti cellular_component owl:Class
GO:0106016 biolink:NamedThing positive regulation of inflammatory response to wounding Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding. got7fsn_ti hjd 2017-04-28T20:16:31Z biological_process owl:Class
GO:0034569 biolink:NamedThing monodemethylisoproturon dehydrogenase activity Catalysis of the reaction: monodemethylisoproturon + H2O = hydroxymonodemethylisoproturon + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0893|EC:1.17.99.- molecular_function owl:Class
GO:0004360 biolink:NamedThing glutamine-fructose-6-phosphate transaminase (isomerizing) activity Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. got7fsn_ti glucosamine 6-phosphate synthase activity|glucosaminephosphate isomerase|L-glutamine:D-fructose-6-phosphate isomerase (deaminating)|glucosamine-6-phosphate synthase activity|L-glutamine-D-fructose-6-phosphate amidotransferase activity|GlcN6P synthase activity|D-fructose-6-phosphate amidotransferase activity|glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity|hexosephosphate aminotransferase activity|glucosamine-6-phosphate isomerase (glutamine-forming) activity MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN|RHEA:13237|EC:2.6.1.16|Reactome:R-HSA-449715|KEGG_REACTION:R00768|Reactome:R-HSA-4085027 molecular_function owl:Class
GO:0016338 biolink:NamedThing calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction. got7fsn_ti calcium-independent cell adhesion molecule activity biological_process owl:Class
GO:0052683 biolink:NamedThing (Z)-gamma-bisabolene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate. got7fsn_ti (2E,6E)-farnesyl-diphosphate diphosphate-lyase [(Z)-gamma-bisabolene-forming] activity MetaCyc:RXN-10005|RHEA:26081|EC:4.2.3.40 molecular_function owl:Class
GO:0071977 biolink:NamedThing bacterial-type flagellum-dependent swimming motility Bacterial-type flagellum-dependent cell motility that results in the smooth movement of a cell through a liquid medium. got7fsn_ti bacterial-type flagellum-mediated cell swimming|bacterial-type flagellar swimming motility mah 2010-10-21T02:58:51Z biological_process owl:Class
GO:0071975 biolink:NamedThing cell swimming Cell motility that results in the smooth movement of a cell through a liquid medium. got7fsn_ti cell swimming motility mah 2010-10-21T02:31:34Z biological_process owl:Class
GO:0031721 biolink:NamedThing hemoglobin alpha binding Binding to a hemoglobin alpha chain. got7fsn_ti molecular_function owl:Class
GO:0030492 biolink:NamedThing hemoglobin binding Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. got7fsn_ti haemoglobin binding|globin binding molecular_function owl:Class
GO:0042629 biolink:NamedThing mast cell granule Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase. got7fsn_ti cellular_component owl:Class
GO:0036508 biolink:NamedThing protein alpha-1,2-demannosylation The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein. got7fsn_ti mannose trimming|glycoprotein mannose trimming Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. bf 2015-06-11T13:58:50Z biological_process owl:Class
GO:0034888 biolink:NamedThing endosulfan monooxygenase I activity Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O. got7fsn_ti UM-BBD_reactionID:r1382 molecular_function owl:Class
GO:0030512 biolink:NamedThing negative regulation of transforming growth factor beta receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway. got7fsn_ti negative regulation of TGF-beta receptor signaling pathway|negative regulation of TGFbeta receptor signaling pathway|down regulation of transforming growth factor beta receptor signaling pathway|downregulation of transforming growth factor beta receptor signaling pathway|inhibition of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signalling pathway|down-regulation of transforming growth factor beta receptor signaling pathway biological_process owl:Class
GO:0009652 biolink:NamedThing thigmotropism The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it. got7fsn_ti Wikipedia:Thigmotropism biological_process owl:Class
GO:0004412 biolink:NamedThing homoserine dehydrogenase activity Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. got7fsn_ti EC:1.1.1.3|RHEA:15761|MetaCyc:HOMOSERDEHYDROG-RXN molecular_function owl:Class
GO:0009949 biolink:NamedThing polarity specification of anterior/posterior axis Any process resulting in the establishment of polarity along the anterior/posterior axis. got7fsn_ti biological_process owl:Class
GO:0018016 biolink:NamedThing N-terminal peptidyl-proline dimethylation The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline. got7fsn_ti RESID:AA0066 biological_process owl:Class
GO:0102125 biolink:NamedThing gibberellin A9 16alpha,17 epoxidase activity Catalysis of the reaction: gibberellin A9 + O2 + H+ + NAD(P)H <=> 16alpha, 17-epoxy gibberellin A9 + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-11388 molecular_function owl:Class
GO:0031773 biolink:NamedThing kisspeptin receptor binding Binding to a kisspeptin receptor. got7fsn_ti hypogonadotropin-1 receptor binding|metastin receptor binding|kisspeptin receptor ligand|G-protein coupled receptor 54 binding|hOT7T175 receptor binding|KiSS-1 receptor binding molecular_function owl:Class
GO:1902408 biolink:NamedThing mitotic cytokinesis, site selection Any cytokinesis, site selection that is involved in mitotic cell cycle. got7fsn_ti site selection involved in cytokinesis involved in mitotic cell cycle|site selection involved in cell cycle cytokinesis involved in mitotic cell cycle jl 2013-09-12T12:29:13Z biological_process owl:Class
GO:0060215 biolink:NamedThing primitive hemopoiesis A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells. got7fsn_ti primitive hematopoiesis|primitive haemopoiesis|primitive haematopoiesis biological_process owl:Class
GO:0018008 biolink:NamedThing N-terminal peptidyl-glycine N-myristoylation The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine. got7fsn_ti N-terminal peptidyl-glycine N-myristylation RESID:AA0059 biological_process owl:Class
GO:0102354 biolink:NamedThing 11-cis-retinol dehydrogenase activity Catalysis of the reaction: 11-cis-retinol + NADP = 11-cis-retinal + NADPH + H+. got7fsn_ti MetaCyc:RXN-13363|RHEA:54912 molecular_function owl:Class
GO:0019929 biolink:NamedThing peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid. got7fsn_ti RESID:AA0315 biological_process owl:Class
GO:0032640 biolink:NamedThing tumor necrosis factor production The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. got7fsn_ti TNF production|tumor necrosis factor biosynthetic process|TNF-alpha production|tumor necrosis factor synthesis|tumor necrosis factor formation|cachectin production|TNF biosynthesis|tumor necrosis factor anabolism|Tnfa production|tumor necrosis factor secretion|tumor necrosis factor-alpha production|TNF-alpha biosynthetic process|tumor necrosis factor biosynthesis|TNF biosynthetic process|TNF alpha biosynthesis|TNF-alpha biosynthesis Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). That this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. sl 2015-06-15T22:59:26Z GO:0042533|GO:1990774 biological_process owl:Class
GO:0044672 biolink:NamedThing acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis. got7fsn_ti CO dehydrogenase complex|carbon-monoxide:(acceptor) oxidoreductase complex|carbon monoxide dehydrogenase|CODH/ACS complex|CODH|CO dehydrogenase/acetyl-CoA synthase complex jl 2012-08-08T16:06:03Z cellular_component owl:Class
GO:0003711 biolink:NamedThing transcription elongation regulator activity A molecular function that regulates transcriptional elongation by enabling the transition from transcription initiation to elongation or by altering the elongation properties of the enzyme during the elongation phase of transcription. got7fsn_ti transcriptional elongation regulator activity|transcription elongation regulator activity|transcription elongation factor activity https://github.com/geneontology/go-ontology/issues/14398 Restored term from obsolete. molecular_function owl:Class
GO:0014012 biolink:NamedThing peripheral nervous system axon regeneration The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury. got7fsn_ti axon regeneration in peripheral nervous system biological_process owl:Class
GO:0047784 biolink:NamedThing cortisol O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cortisol = CoA + cortisol 21-acetate. got7fsn_ti cortisol acetyltransferase activity|corticosteroid acetyltransferase activity|acetyl-CoA:cortisol O-acetyltransferase activity|corticosteroid-21-O-acetyltransferase activity MetaCyc:CORTISOL-O-ACETYLTRANSFERASE-RXN|KEGG_REACTION:R02837|RHEA:17073|EC:2.3.1.27 molecular_function owl:Class
GO:0051915 biolink:NamedThing induction of synaptic plasticity by chemical substance The process in which a chemical substance activates synaptic plasticity, the ability of synapses to change as circumstances require. got7fsn_ti activation of synaptic plasticity by drug|activation of synaptic plasticity by chemical substance|induction of synaptic plasticity by drug biological_process owl:Class
GO:0051914 biolink:NamedThing positive regulation of synaptic plasticity by chemical substance The process in which a chemical substance increases synaptic plasticity, the ability of synapses to change as circumstances require. got7fsn_ti stimulation of synaptic plasticity by chemical substance|positive regulation of synaptic plasticity by drug|up-regulation of synaptic plasticity by chemical substance|up regulation of synaptic plasticity by chemical substance|activation of synaptic plasticity by chemical substance|upregulation of synaptic plasticity by chemical substance biological_process owl:Class
GO:0103001 biolink:NamedThing dimethylsulfoxide oxygenase activity Catalysis of the reaction: dimethyl sulfoxide + O2 + NADPH + H+ <=> sulfonyldimethane + H2O + NADP. got7fsn_ti RHEA:57956|MetaCyc:RXN-9767 molecular_function owl:Class
GO:0103046 biolink:NamedThing alanylglutamate dipeptidase activity Catalysis of the reaction: L-alanyl-L-glutamate + H2O <=> L-alanine + L-glutamate. got7fsn_ti MetaCyc:RXN0-6981|EC:3.4.13.18 molecular_function owl:Class
GO:0000210 biolink:NamedThing NAD+ diphosphatase activity Catalysis of the reaction: NAD+ + H2O = AMP + NMN. got7fsn_ti NADH pyrophosphatase activity|NADP pyrophosphatase activity|NAD diphosphatase activity|NAD+ pyrophosphatase activity|NAD pyrophosphatase activity|NAD(+) pyrophosphatase activity|NAD+ phosphohydrolase activity|nicotinamide adenine dinucleotide pyrophosphatase activity MetaCyc:NADPYROPHOSPHAT-RXN|EC:3.6.1.22|RHEA:11800 molecular_function owl:Class
GO:0017098 biolink:NamedThing sulfonylurea receptor binding Binding to a sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel. got7fsn_ti sulfonylurea receptor ligand|sulphonylurea receptor binding molecular_function owl:Class
GO:0046405 biolink:NamedThing glycerol dehydratase activity Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. got7fsn_ti glycerol hydro-lyase activity|glycerol dehydrase activity|glycerol hydro-lyase (3-hydroxypropanal-forming) MetaCyc:GLYCEROL-DEHYDRATASE-RXN|EC:4.2.1.30|RHEA:19765 molecular_function owl:Class
GO:0004740 biolink:NamedThing pyruvate dehydrogenase (acetyl-transferring) kinase activity Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. got7fsn_ti PDK|PDH kinase activity|pyruvate dehydrogenase kinase activity|pyruvate dehydrogenase kinase (phosphorylating) activity|PDHK Reactome:R-HSA-203946|EC:2.7.11.2|RHEA:23052|MetaCyc:2.7.11.2-RXN molecular_function owl:Class
GO:0045156 biolink:NamedThing electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. got7fsn_ti cytochrome bc1 complex|cytochrome molecular_function owl:Class
GO:0030273 biolink:NamedThing melanin-concentrating hormone receptor activity Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity. got7fsn_ti MCH receptor molecular_function owl:Class
GO:0004957 biolink:NamedThing prostaglandin E receptor activity Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. got7fsn_ti PGE receptor activity|PGE(2) receptor activity molecular_function owl:Class
GO:0102485 biolink:NamedThing dATP phosphohydrolase activity Catalysis of the reaction: dATP + 2 H2O = dAMP + 2 hydrogenphosphate + 2 H+. got7fsn_ti EC:3.6.1.5|MetaCyc:RXN-14195 molecular_function owl:Class
GO:0018388 biolink:NamedThing N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine. got7fsn_ti RESID:AA0275 biological_process owl:Class
GO:0098608 biolink:NamedThing methylselenol demethylase activity Catalysis of the reaction: methylselenol + H2O => H2Se + CH3OH. got7fsn_ti dos 2014-04-16T11:28:00Z Reactome:R-HSA-2408530 molecular_function owl:Class
GO:0006428 biolink:NamedThing isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0050626 biolink:NamedThing trimethylamine-N-oxide reductase (cytochrome c) activity Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+. got7fsn_ti trimethylamine:cytochrome c oxidoreductase activity|TOR activity|TMAO reductase activity MetaCyc:1.7.2.3-RXN|EC:1.7.2.3|RHEA:24236|Wikipedia:Trimethylamine_N-oxide_reductase molecular_function owl:Class
GO:0018769 biolink:NamedThing 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate. got7fsn_ti UM-BBD_reactionID:r0311 molecular_function owl:Class
GO:0070691 biolink:NamedThing P-TEFb complex A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T. got7fsn_ti Bur1/Bur2 complex|cyclin-dependent kinase 9 (Cdk9)-cyclin T2 complex|dimeric positive transcription elongation factor complex b|cyclin-dependent kinase 9 (Cdk9)-cyclin T1 complex|Sgv1/Bur2 complex mah 2009-06-03T03:12:56Z cellular_component owl:Class
GO:0052844 biolink:NamedThing inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+. got7fsn_ti ai 2011-12-05T10:59:26Z MetaCyc:RXN-10978 molecular_function owl:Class
GO:0090445 biolink:NamedThing positive regulation of nematode larval development, heterochronic Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached. got7fsn_ti tb 2012-08-24T13:24:43Z biological_process owl:Class
GO:0017041 biolink:NamedThing galactosylgalactosylglucosylceramidase activity Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose. got7fsn_ti D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity|trihexosylceramide alpha-galactosidase activity|ceramide trihexosidase activity|trihexosyl ceramide galactosidase activity|ceramidetrihexosidase activity|ceramidetrihexoside alpha-galactosidase activity EC:3.2.1.47|MetaCyc:3.2.1.47-RXN|RHEA:21112 molecular_function owl:Class
GO:0055093 biolink:NamedThing response to hyperoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension. got7fsn_ti response to increased oxygen tension|response to hyperoxic stress biological_process owl:Class
GO:0052591 biolink:NamedThing sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8. got7fsn_ti Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. RHEA:28751|MetaCyc:GLYC3PDEHYDROG-RXN|EC:1.1.5.3 molecular_function owl:Class
GO:0042786 biolink:NamedThing evasion of host immune response via regulation of host antigen processing and presentation Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti active immune evasion via modulation of antigen processing/presentation|active immune evasion via regulation of antigen processing and presentation|active immune evasion via modulation of antigen processing and presentation|active evasion of immune response of other organism via regulation of antigen processing and presentation in other organism involved in symbiotic interaction|active evasion of host immune response via regulation of host antigen processing and presentation|active evasion of host immune response via regulation of host antigen processing and presentation pathway GO:0051813 biological_process owl:Class
GO:0097471 biolink:NamedThing mossy fiber rosette A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes. got7fsn_ti cerebellar mossy fiber to granule cell synapse pr 2013-02-21T07:42:52Z NIF_Subcellular:nlx_subcell_091021 cellular_component owl:Class
GO:0002050 biolink:NamedThing pyoverdine catabolic process The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine. got7fsn_ti biological_process owl:Class
GO:0102373 biolink:NamedThing uvaol dehydrogenase activity Catalysis of the reaction: uvaol + NADPH + O2 + H+ <=> ursolic aldehyde + NADP + 2 H2O. got7fsn_ti EC:1.14.14.126|MetaCyc:RXN-13501 molecular_function owl:Class
GO:0072061 biolink:NamedThing inner medullary collecting duct development The process whose specific outcome is the progression of the inner medullary collecting duct over time, from its formation to the mature structure. The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla. got7fsn_ti mah 2010-01-25T04:08:45Z biological_process owl:Class
GO:0098756 biolink:NamedThing response to interleukin-21 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-21 stimulus. got7fsn_ti response to IL-21 biological_process owl:Class
GO:0106151 biolink:NamedThing CNBH domain intrinsic ligand binding Interacting selectivity and noncovalently with a cyclic nucleotide mimicking protein motif that is part of the same protein. The CNBHD is a domain on KCNH channels that creates a binding pocket on the KCNH channel that resembles the cyclic nucleotide- binding domain on other ion channels. It binds to a peptide motif that is part of the same protein rather than a cyclic nucleotide. got7fsn_ti It is unclear if the motif bound by CNBHD is a specific motif or just a beta sheet with the appropriate amino acids. hjd 2018-09-18T20:47:35Z molecular_function owl:Class
GO:0000834 biolink:NamedThing inositol heptakisphosphate 6-kinase activity Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate. got7fsn_ti molecular_function owl:Class
GO:0047185 biolink:NamedThing N-acetylneuraminate 4-O-acetyltransferase activity Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-4-O-acetylneuraminate + CoA. got7fsn_ti sialate O-acetyltransferase|acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity EC:2.3.1.44|MetaCyc:2.3.1.44-RXN|RHEA:18305|KEGG_REACTION:R01806 molecular_function owl:Class
GO:0102862 biolink:NamedThing 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming) Catalysis of the reaction: 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + O2 + a reduced electron acceptor = 1-18:2-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8329|EC:1.14.19.25 molecular_function owl:Class
GO:0070702 biolink:NamedThing inner mucus layer The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria. got7fsn_ti mah 2009-06-08T02:38:55Z cellular_component owl:Class
GO:0010590 biolink:NamedThing regulation of septum digestion after cytokinesis Any process that modulates the rate, frequency or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. got7fsn_ti regulation of cell separation following cytokinesis|regulation of cell separation after cytokinesis|regulation of mitotic cytokinetic cell separation GO:1902467|GO:2001041 biological_process owl:Class
GO:0120113 biolink:NamedThing cytoplasm to vacuole transport by the NVT pathway A pathway targeting soluble cytosolic proteins to the vacuole lumen. It uses a selective autophagy receptor protein Nbr1, which is an ortholog of mammalian NBR1, and is remotely related to S. cerevisiae Cvt pathway receptor protein Atg19. Similar to the Cvt pathway, the cargos transported by this pathway are hydrolases, which presumably contribute to the hydrolytic activities in the vacuole lumen. Different from the Cvt pathway, this pathway does not require the macroautophagy machinery, but instead relies on the ESCRT machinery for cargo sequestration. This pathway is observed in the fission yeast S. pombe. got7fsn_ti protein localization by the NVT pathway|protein localization by the Nbr1-mediated vacuolar targeting pathway|cytoplasm-to-vacuole targeting|cytoplasm to vacuole targeting krc 2017-11-03T16:07:55Z biological_process owl:Class
GO:1990268 biolink:NamedThing response to gold nanoparticle Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus. got7fsn_ti sl 2014-01-10T17:37:34Z biological_process owl:Class
GO:0140523 biolink:NamedThing GTPase-dependent fusogenic activity A GTPase activity that mediates the joining two lipid bilayers to form a single membrane. got7fsn_ti membrane fusion GTPase activity https://github.com/geneontology/go-ontology/issues/19942 pg 2020-09-24T09:49:40Z molecular_function owl:Class
GO:0140522 biolink:NamedThing fusogenic activity The activity of joining two lipid bilayers to form a single membrane. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19942 pg 2020-09-24T09:45:21Z molecular_function owl:Class
GO:0140664 biolink:NamedThing ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21662 pg 2021-06-19T16:37:21Z molecular_function owl:Class
GO:0034526 biolink:NamedThing 2-methylnaphthalene hydroxylase activity Catalysis of the reaction: 2-methylnaphthalene + NADH + O2 + H+ = 2-hydroxymethylnaphthalene + NAD+ + H2O. got7fsn_ti UM-BBD_reactionID:r0788|EC:1.14.13.- molecular_function owl:Class
GO:0036242 biolink:NamedThing glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase. got7fsn_ti glutamate degradation via gamma aminobutyrate transaminase activity While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants. bf 2012-05-23T02:28:33Z MetaCyc:PWY-4321|MetaCyc:PWY3O-210 biological_process owl:Class
GO:0045504 biolink:NamedThing dynein heavy chain binding Binding to a heavy chain of the dynein complex. got7fsn_ti molecular_function owl:Class
GO:0036430 biolink:NamedThing CMP kinase activity Catalysis of the reaction: ATP + CMP = ADP + CDP. got7fsn_ti bf 2013-09-16T14:11:48Z MetaCyc:RXN-11832|RHEA:11600|KEGG_REACTION:R00512 molecular_function owl:Class
GO:0036311 biolink:NamedThing chitin disaccharide deacetylase activity Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate. got7fsn_ti chitobiose amidohydrolase activity|chitin oligosaccharide deacetylase activity|chitin oligosaccharide amidohydrolase activity In contrast to EC:3.5.1.41 (chitin deacetylase) this enzyme is specific for the chitin disaccharide. bf 2012-08-15T15:18:09Z molecular_function owl:Class
GO:0034199 biolink:NamedThing activation of protein kinase A activity Any process that initiates the activity of the inactive enzyme protein kinase A. got7fsn_ti protein kinase A activation biological_process owl:Class
GO:0048109 biolink:NamedThing peptide cross-linking via 2-amino-3-isothiazolidinone-L-serine The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link through a process of forming first an intermediate cysteine sulfenic acid by peroxide oxidation, followed by condensation with the alpha-amido of the following serine residue and the release of water. got7fsn_ti RESID:AA0344 biological_process owl:Class
GO:0102677 biolink:NamedThing campesterol,NADPH:oxygen oxidoreductase activity Catalysis of the reaction: H+ + campesterol + O2 + NADPH <=> (22S)-22-hydroxycampesterol + H2O + NADP. got7fsn_ti MetaCyc:RXN-4225 molecular_function owl:Class
GO:0032447 biolink:NamedThing protein urmylation Covalent attachment of the ubiquitin-like protein URM1 to another protein. got7fsn_ti biological_process owl:Class
GO:0010203 biolink:NamedThing response to very low fluence red light stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec. got7fsn_ti biological_process owl:Class
GO:0047189 biolink:NamedThing 2,3-diaminopropionate N-oxalyltransferase activity Catalysis of the reaction: 3-amino-L-alanine + oxalyl-CoA = N(3)-oxalyl-L-2,3-diaminopropanoate + CoA. got7fsn_ti oxalyl-CoA:L-2,3-diaminopropanoate N3-oxalyltransferase activity|oxalyldiaminopropionate synthase activity|oxalyldiaminopropionic synthase activity|ODAP synthase activity|oxalyl-CoA:L-2,3-diaminopropanoate 3-N-oxalyltransferase activity|oxalyl-CoA:L-alpha,beta-diaminopropionic acid oxalyltransferase activity EC:2.3.1.58|KEGG_REACTION:R04211|MetaCyc:2.3.1.58-RXN|RHEA:13465 molecular_function owl:Class
GO:0031995 biolink:NamedThing insulin-like growth factor II binding Binding to insulin-like growth factor II. got7fsn_ti IGF-II binding molecular_function owl:Class
GO:0033852 biolink:NamedThing thyroid-hormone transaminase activity Catalysis of the reaction: 2-oxoglutarate + 3,5,3'-triiodo-L-thyronine = 3,5,3'-triiodothyropyruvate + L-glutamate. got7fsn_ti 3,5-dinitrotyrosine transaminase activity|thyroid-hormone aminotransferase activity|L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase activity|3,5-dinitrotyrosine aminotransferase activity|thyroid hormone aminotransferase activity EC:2.6.1.26|MetaCyc:THYROID-HORMONE-AMINOTRANSFERASE-RXN|RHEA:19133|KEGG_REACTION:R03952 molecular_function owl:Class
GO:0001987 biolink:NamedThing vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure. got7fsn_ti biological_process owl:Class
GO:0006168 biolink:NamedThing adenine salvage Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. got7fsn_ti adenine salvage pathway|adenine, hypoxanthine and their nucleoside salvage biological_process owl:Class
GO:0046084 biolink:NamedThing adenine biosynthetic process The chemical reactions and pathways resulting in the formation of adenine, 6-aminopurine, one of the five main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine. got7fsn_ti adenine synthesis|adenine anabolism|adenine biosynthesis|adenine formation biological_process owl:Class
GO:0021990 biolink:NamedThing neural plate formation The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system. got7fsn_ti biological_process owl:Class
GO:0099520 biolink:NamedThing ion antiporter activity involved in regulation of presynaptic membrane potential Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. got7fsn_ti ion antiporter activity involved in regulation of pre-synaptic membrane potential molecular_function owl:Class
GO:0047894 biolink:NamedThing flavonol 3-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin = adenosine 3',5'-diphosphate + H(+) + quercetin 3-sulfate. got7fsn_ti flavonol 3-sulphotransferase activity|3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase activity MetaCyc:FLAVONOL-3-SULFOTRANSFERASE-RXN|KEGG_REACTION:R02159|RHEA:13453|EC:2.8.2.25 molecular_function owl:Class
GO:0034812 biolink:NamedThing 9,10-dihydroxybenzo(a)pyrene dioxygenase activity Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r1134 molecular_function owl:Class
GO:0102531 biolink:NamedThing ecdysteroid-phosphate phosphatase activity Catalysis of the reaction: H2O + an ecdysteroid 22-phosphate = hydrogenphosphate + an ecdysteroid. got7fsn_ti RHEA:63576|MetaCyc:RXN-14734 molecular_function owl:Class
GO:0071198 biolink:NamedThing Kv4.1-DPP6 channel complex A voltage-gated potassium channel complex that contains the peptidase-related protein DPP6 associated with the channel via interaction with the Kv alpha subunit 4.1. got7fsn_ti Kv4.1-DPPX channel complex mah 2009-11-23T05:14:37Z CORUM:600 cellular_component owl:Class
GO:0019518 biolink:NamedThing L-threonine catabolic process to glycine The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine. got7fsn_ti L-threonine catabolism to glycine|L-threonine degradation to glycine|L-threonine catabolic process to pyruvate|threonine catabolic process to glycine|L-threonine breakdown to glycine MetaCyc:THREONINE-DEG2-PWY biological_process owl:Class
GO:0021650 biolink:NamedThing vestibulocochlear nerve formation The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. got7fsn_ti CN VII formation biological_process owl:Class
GO:0046589 biolink:NamedThing ribonuclease T1 activity Catalysis of the endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Gp with 2',3'-cyclic phosphate intermediates. got7fsn_ti RNase G|RNase Sa|RNase T1|ribonuclease Ch|binase activity|RNase T1 activity|RNase N1 activity|ribonuclease C2|ribonuclease N3|ribonuclease F1|ribonuclease PP1|ribonuclease N1|guanyloribonuclease activity|guanyl-specific RNase activity|Aspergillus oryzae ribonuclease activity|ribonuclease guaninenucleotido-2'-transferase (cyclizing)|RNase F1|ribonuclease U1|RNase N2 activity|ribonuclease SA EC:4.6.1.24|MetaCyc:3.1.27.3-RXN molecular_function owl:Class
GO:0043221 biolink:NamedThing SMC family protein binding Binding to a protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization. got7fsn_ti structural maintenance of chromosomes family protein binding molecular_function owl:Class
GO:0039593 biolink:NamedThing suppression by virus of host exit from mitosis Any viral process which decreases the rate or extent of a host cell leaving M phase of the cell cycle. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. got7fsn_ti inhibition of host mitotic exit by virus bf 2012-06-25T02:21:20Z VZ:877 biological_process owl:Class
GO:0018776 biolink:NamedThing trans-chloroacrylic acid dehalogenase activity Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde. got7fsn_ti UM-BBD_reactionID:r0689 molecular_function owl:Class
GO:0031431 biolink:NamedThing Dbf4-dependent protein kinase complex A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins. got7fsn_ti DDK|Hsk1-Dfp1 kinase complex|Cdc7-Dbf4 complex cellular_component owl:Class
GO:0071883 biolink:NamedThing MAPK-activating adrenergic receptor signaling pathway The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand and leading to the activation of a MAP kinase cascade. got7fsn_ti activation of MAP kinase activity by adrenergic receptor signalling pathway|activation of MAPK activity by adrenergic receptor signalling pathway|activation of MAPK activity by adrenergic receptor signaling pathway|activation of MAP kinase activity by adrenergic receptor signaling pathway https://github.com/geneontology/go-ontology/issues/21544 mah 2010-09-13T04:34:47Z biological_process owl:Class
GO:0085019 biolink:NamedThing formation of tubovesicular network for nutrient acquisition The assembly of a symbiont-induced complex organelle that comprises of multiple protein and lipid domains for the purpose of obtaining nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti formation by symbiont of a tubovesicular network for nutrient acquisition from host|formation of a symbiont- induced tubovesicular network for nutrient acquisition from host https://github.com/geneontology/go-ontology/issues/20305 jl 2010-05-20T04:29:24Z biological_process owl:Class
GO:0016894 biolink:NamedThing endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. got7fsn_ti 3'-endonuclease activity|endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters Note that this activity can catalyze cleavage of DNA or RNA. EC:3.1.31.- molecular_function owl:Class
GO:0080031 biolink:NamedThing methyl salicylate esterase activity Catalysis of the reaction: methyl salicylate + H2O = salicylic acid + methanol + H+. got7fsn_ti methylsalicylate esterase activity|methyl SA esterase activity|salicylic acid methyl ester esterase activity|MESA esterase activity MetaCyc:RXNQT-4366 molecular_function owl:Class
GO:0047203 biolink:NamedThing 13-hydroxylupinine O-tigloyltransferase activity Catalysis of the reaction: 13-hydroxylupanine + 2-methylcrotonoyl-CoA = 13-(2-methylcrotonoyloxy)lupanine + CoA. got7fsn_ti tigloyl-CoA:13-hydroxylupanine O-tigloyltransferase activity|(E)-2-methylcrotonoyl-CoA:13-hydroxylupinine O-2-methylcrotonoyltransferase activity|13-hydroxylupanine acyltransferase activity MetaCyc:2.3.1.93-RXN|KEGG_REACTION:R04205|RHEA:12360|EC:2.3.1.93 molecular_function owl:Class
GO:0018448 biolink:NamedThing hydroxymethylmethylsilanediol oxidase activity Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O. got7fsn_ti UM-BBD_reactionID:r0638 molecular_function owl:Class
GO:0045544 biolink:NamedThing gibberellin 20-oxidase activity Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones. got7fsn_ti molecular_function owl:Class
GO:0033079 biolink:NamedThing immature T cell proliferation The expansion of an immature T cell population by cell division. got7fsn_ti biological_process owl:Class
GO:0007385 biolink:NamedThing specification of segmental identity, abdomen The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti biological_process owl:Class
GO:0046738 biolink:NamedThing induction of innate immune response in host by virus The intentional, virally-encoded stimulation of an innate host defense response to viral infection. got7fsn_ti active induction of innate immune response in host by virus|active viral induction of innate immune response in host biological_process owl:Class
GO:0044602 biolink:NamedThing protein deadenylylation The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid. got7fsn_ti protein deAMPylation jl 2012-05-01T04:16:22Z biological_process owl:Class
GO:0047239 biolink:NamedThing hydroxymandelonitrile glucosyltransferase activity Catalysis of the reaction: 4-hydroxymandelonitrile + UDP-D-glucose = H(+) + taxiphyllin + UDP. got7fsn_ti cyanohydrin glucosyltransferase activity|UDP-glucose:4-hydroxymandelonitrile glucosyltransferase activity|UDPglucose:4-hydroxymandelonitrile glucosyltransferase activity EC:2.4.1.178|RHEA:15961|MetaCyc:2.4.1.178-RXN|KEGG_REACTION:R02709 molecular_function owl:Class
GO:0036152 biolink:NamedThing phosphatidylethanolamine acyl-chain remodeling Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. got7fsn_ti bf 2012-03-14T02:09:00Z biological_process owl:Class
GO:0046470 biolink:NamedThing phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. got7fsn_ti phosphatidylcholine metabolism biological_process owl:Class
GO:0007451 biolink:NamedThing dorsal/ventral lineage restriction, imaginal disc Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment. got7fsn_ti dorsal-ventral lineage restriction, imaginal disc|dorsoventral lineage restriction, imaginal disc biological_process owl:Class
GO:0045464 biolink:NamedThing R8 cell fate specification The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0003923 biolink:NamedThing GPI-anchor transamidase activity Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor. got7fsn_ti Reactome:R-HSA-162836 molecular_function owl:Class
GO:0098872 biolink:NamedThing G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse. got7fsn_ti G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration|G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels molecular_function owl:Class
GO:0043719 biolink:NamedThing 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O. got7fsn_ti MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN|EC:1.14.13.- molecular_function owl:Class
GO:0045459 biolink:NamedThing iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide. got7fsn_ti iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl triiron tetrasulphide RESID:AA0326 biological_process owl:Class
GO:0038159 biolink:NamedThing C-X-C chemokine receptor CXCR4 signaling pathway A series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti CXCR4 signaling pathway bf 2012-05-14T01:33:17Z biological_process owl:Class
GO:0004370 biolink:NamedThing glycerol kinase activity Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+). got7fsn_ti glycerol kinase (phosphorylating)|ATP:glycerol 3-phosphotransferase activity|ATP:glycerol-3-phosphotransferase activity|GK|glyceric kinase activity|glycerokinase activity MetaCyc:GLYCEROL-KIN-RXN|EC:2.7.1.30|KEGG_REACTION:R00847|RHEA:21644|Reactome:R-HSA-75887 molecular_function owl:Class
GO:0051002 biolink:NamedThing ligase activity, forming nitrogen-metal bonds Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. got7fsn_ti EC:6.6.-.- molecular_function owl:Class
GO:0010999 biolink:NamedThing regulation of eIF2 alpha phosphorylation by heme Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels. got7fsn_ti tb 2009-06-10T11:42:10Z biological_process owl:Class
GO:0010770 biolink:NamedThing positive regulation of cell morphogenesis involved in differentiation Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. got7fsn_ti biological_process owl:Class
GO:0042349 biolink:NamedThing guiding stereospecific synthesis activity The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis. got7fsn_ti dirigent protein molecular_function owl:Class
GO:1990434 biolink:NamedThing lower tip-link density An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises. got7fsn_ti LTLD sl 2014-07-30T16:34:34Z cellular_component owl:Class
GO:0017166 biolink:NamedThing vinculin binding Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. got7fsn_ti molecular_function owl:Class
GO:0015941 biolink:NamedThing pantothenate catabolic process The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. got7fsn_ti pantothenate catabolism|vitamin B5 catabolic process|pantothenate breakdown|pantothenate degradation|vitamin B5 catabolism biological_process owl:Class
GO:0007144 biolink:NamedThing female meiosis I The cell cycle process in which the first meiotic division occurs in the female germline. got7fsn_ti female meiosis I nuclear division biological_process owl:Class
GO:0071095 biolink:NamedThing alpha3-beta1 integrin-thrombospondin complex A protein complex that consists of an alpha3-beta1 integrin complex bound to thrombospondin. got7fsn_ti ITGA3-ITGB1-THBS1 complex mah 2009-11-06T04:48:03Z cellular_component owl:Class
GO:0019086 biolink:NamedThing late viral transcription The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins. got7fsn_ti late viral mRNA transcription biological_process owl:Class
GO:0099118 biolink:NamedThing microtubule-based protein transport A microtubule-based process that results in the transport of proteins. got7fsn_ti biological_process owl:Class
GO:0004657 biolink:NamedThing proline dehydrogenase activity Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. got7fsn_ti L-proline:(acceptor) oxidoreductase activity|L-proline dehydrogenase activity|L-proline:acceptor oxidoreductase activity MetaCyc:RXN-7181|EC:1.5.99.8|Reactome:R-HSA-8955817|Reactome:R-HSA-6784224|Reactome:R-HSA-70670|RHEA:23784 molecular_function owl:Class
GO:0102304 biolink:NamedThing sesquithujene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> 7-epi-sesquithujene + diphosphoric acid. got7fsn_ti EC:4.2.3.102|MetaCyc:RXN-12838|RHEA:31991 molecular_function owl:Class
GO:0031775 biolink:NamedThing lutropin-choriogonadotropic hormone receptor binding Binding to a lutropin-choriogonadotropic hormone receptor. got7fsn_ti lutropin-choriogonadotropic hormone receptor ligand molecular_function owl:Class
GO:0102409 biolink:NamedThing sn-2-glycerol-3-phosphate C16:0-CoA acyl transferase activity Catalysis of the reaction: behenoyl-CoA + sn-glycerol 3-phosphate(2-) <=> coenzyme A + 2-docosanoyl-glycerol 3-phosphate. got7fsn_ti MetaCyc:RXN-13736 molecular_function owl:Class
GO:0019807 biolink:NamedThing aspartoacylase activity Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate. got7fsn_ti N-acyl-L-aspartate amidohydrolase activity|acylase II|N-acetylaspartate amidohydrolase activity|aminoacylase II activity|acetyl-aspartic deaminase activity MetaCyc:ASPARTOACYLASE-RXN|Reactome:R-HSA-5691507|RHEA:10872|EC:3.5.1.15 molecular_function owl:Class
GO:0016966 biolink:NamedThing nitric oxide reductase activity Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide. got7fsn_ti CYP55|P450 nitric oxide reductase activity|nitrous-oxide:acceptor oxidoreductase (NO-forming)|nitrous-oxide:(acceptor) oxidoreductase (NO-forming)|cytochrome bc nitric oxide reductase activity|P450nor|nitrogen oxide reductase activity|nitric-oxide reductase activity GO:0016967|GO:0016968 MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN|KEGG_REACTION:R00294|EC:1.7.2.5|RHEA:30211 molecular_function owl:Class
GO:2000368 biolink:NamedThing positive regulation of acrosomal vesicle exocytosis Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis. got7fsn_ti positive regulation of acrosomal granule exocytosis|positive regulation of acrosome exocytosis yaf 2011-02-07T11:52:42Z biological_process owl:Class
GO:0005171 biolink:NamedThing hepatocyte growth factor receptor binding Binding to an hepatocyte growth factor receptor. got7fsn_ti HGF receptor binding|hepatocyte growth factor|hepatocyte growth factor receptor ligand molecular_function owl:Class
GO:0090618 biolink:NamedThing DNA clamp unloading The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates. got7fsn_ti PCNA unloading tb 2014-10-29T12:57:05Z biological_process owl:Class
GO:0002000 biolink:NamedThing detection of renal blood flow The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal. got7fsn_ti biological_process owl:Class
GO:0090580 biolink:NamedThing phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand. got7fsn_ti tb 2014-05-14T15:52:41Z molecular_function owl:Class
GO:0005883 biolink:NamedThing neurofilament A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter. got7fsn_ti type IV intermediate filament Wikipedia:Neurofilament|NIF_Subcellular:sao1316272517 cellular_component owl:Class
GO:1990518 biolink:NamedThing single-stranded 3'-5' DNA helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'. got7fsn_ti al 2014-10-22T10:17:40Z molecular_function owl:Class
GO:1900819 biolink:NamedThing orlandin metabolic process The chemical reactions and pathways involving orlandin. got7fsn_ti orlandin metabolism di 2012-06-04T10:14:55Z biological_process owl:Class
GO:0102607 biolink:NamedThing 3beta-hydroxy-12,15-cassadiene-11-one 2-hydroxylase activity Catalysis of the reaction: 3beta-hydroxy-12,15-cassadiene-11-one + NADPH + O2 + H+ <=> 2beta,3beta-dihydroxy-12,15-cassadiene-11-one + NADP + H2O. got7fsn_ti MetaCyc:RXN-15433 molecular_function owl:Class
GO:0000713 biolink:NamedThing meiotic heteroduplex formation During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules. got7fsn_ti biological_process owl:Class
GO:0001856 biolink:NamedThing complement component C5a binding Binding to a C5a product of the complement cascade. got7fsn_ti molecular_function owl:Class
GO:0006124 biolink:NamedThing ferredoxin metabolic process The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each. got7fsn_ti ferredoxin metabolism biological_process owl:Class
GO:0014702 biolink:NamedThing free sarcoplasmic reticulum membrane The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane. got7fsn_ti cellular_component owl:Class
GO:0047481 biolink:NamedThing D-alanine-alanyl-poly(glycerolphosphate) ligase activity Catalysis of the reaction: alanyl-poly(glycerolphosphate) + D-alanine + ATP = D-alanyl-alanyl-poly(glycerolphosphate) + phosphate + ADP. got7fsn_ti D-alanine:membrane-acceptor ligase activity|D-alanyl-poly(phosphoglycerol) synthetase activity|D-alanine:alanyl-poly(glycerolphosphate) ligase (ADP-forming)|D-alanyl-alanyl-poly(glycerolphosphate) synthetase activity|D-alanylalanylpoly(phosphoglycerol) synthetase activity|D-alanine-membrane acceptor-ligase activity MetaCyc:6.3.2.16-RXN|EC:6.3.2.16 molecular_function owl:Class
GO:0035582 biolink:NamedThing sequestering of BMP in extracellular matrix Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins. got7fsn_ti BMP sequestration in the ECM|negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex. bf 2010-10-12T03:12:45Z biological_process owl:Class
GO:0102825 biolink:NamedThing quercetin 3-O-rhamnoside-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + quercetin 3-O-rhamnoside <=> quercetin 3-O-rhamnoside-7-O-glucoside + UDP. got7fsn_ti MetaCyc:RXN-8268 molecular_function owl:Class
GO:0106323 biolink:NamedThing (S)-limonene 1,2-monooxygenase NADPH activity Catalysis of the reaction: (4S)-limonene + NADPH+= + H+ + O2 = NADP+ + H2O + (4S)-limonene-1,2-epoxide. got7fsn_ti hjd 2020-09-23T15:35:43Z RHEA:26085 molecular_function owl:Class
GO:0035754 biolink:NamedThing B cell chemotaxis The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti bf 2011-03-23T10:30:33Z biological_process owl:Class
GO:0036366 biolink:NamedThing transforming growth factor beta3 activation The release of transforming growth factor beta 3 (TGF-beta3) from its latent state. got7fsn_ti TGF-beta 3 activation|TGFB3 activation|TGFbeta 3 activation bf 2012-09-24T10:16:05Z biological_process owl:Class
GO:0031479 biolink:NamedThing myosin IX complex A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins. got7fsn_ti cellular_component owl:Class
GO:1990935 biolink:NamedThing splicing factor binding Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA. got7fsn_ti sl 2016-03-21T21:57:20Z molecular_function owl:Class
GO:0061732 biolink:NamedThing mitochondrial acetyl-CoA biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate in the mitochondrion. The process begins with the transport of pyruvate from the cytosol to the mitochondrion where it is subsequently decarboxylated to form acetyl-CoA. got7fsn_ti dph 2015-08-24T13:44:02Z Reactome:R-HSA-372342.1|Reactome:R-HSA-71397.1 biological_process owl:Class
GO:0007121 biolink:NamedThing bipolar cellular bud site selection The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell. got7fsn_ti polar budding|bipolar budding|bipolar bud site selection biological_process owl:Class
GO:0062240 biolink:NamedThing euchromatin-nuclear membrane anchor activity Binding to euchromatin and the nuclear inner membrane, in order to establish and maintain the euchromatin location and organization. got7fsn_ti euchromatin-nuclear membrane tether activity|nuclear membrane-euchromatin anchor activity|nuclear membrane-euchromatin tether activity dph 2020-04-20T18:22:35Z molecular_function owl:Class
GO:0047122 biolink:NamedThing quinaldate 4-oxidoreductase activity Catalysis of the reaction: A + H(2)O + quinaldate = AH(2) + kynurenate. got7fsn_ti quinaldic acid 4-oxidoreductase activity|quinoline-2-carboxylate:acceptor 4-oxidoreductase (hydroxylating) KEGG_REACTION:R03687|MetaCyc:1.3.99.18-RXN|EC:1.3.99.18|RHEA:16697 molecular_function owl:Class
GO:0071919 biolink:NamedThing G-quadruplex DNA formation A DNA metabolic process that results in the formation of G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad or G-quartet. The stacking of several layers of G-quartets forms G-quadruplexes, in which one or more DNA single strands are assembled in parallel and/or antiparallel, with interactions that can be either intra- or intermolecular in nature. got7fsn_ti G quartet DNA formation|G-quartet DNA formation|G quadruplex DNA formation mah 2010-09-24T10:57:43Z biological_process owl:Class
GO:0102772 biolink:NamedThing sphingolipid long-chain base 4-hydroxylase activity Catalysis of the reaction: O2 + H+ + a dihydroceramide + NAD(P)H = H2O + a phytoceramide + NAD(P). got7fsn_ti MetaCyc:RXN-7797 molecular_function owl:Class
GO:0015018 biolink:NamedThing galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. got7fsn_ti UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity|uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity|glucuronosyltransferase I activity|UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity RHEA:24168|EC:2.4.1.135|Reactome:R-HSA-9638064|Reactome:R-HSA-1889955|Reactome:R-HSA-3560802|MetaCyc:2.4.1.135-RXN molecular_function owl:Class
GO:0002551 biolink:NamedThing mast cell chemotaxis The movement of a mast cell in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0050967 biolink:NamedThing detection of electrical stimulus involved in sensory perception of pain The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal. got7fsn_ti detection of electrical stimulus during sensory perception of pain|perception of pain, detection of electrical stimulus|sensory transduction of electrical stimulus during perception of pain|perception of pain, sensory detection of electrical stimulus|sensory detection of electrical stimulus during perception of pain|perception of pain, sensory transduction of electrical stimulus biological_process owl:Class
GO:0055002 biolink:NamedThing striated muscle cell development The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. got7fsn_ti biological_process owl:Class
GO:0008623 biolink:NamedThing CHRAC An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair. got7fsn_ti chromatin accessibility complex|ISW2 complex GO:0016588 cellular_component owl:Class
GO:0061751 biolink:NamedThing neutral sphingomyelin phosphodiesterase activity Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+) in a neutral environment. got7fsn_ti neutral SMase|neutral sphingomyelinase dph 2015-11-11T14:48:08Z molecular_function owl:Class
GO:0002087 biolink:NamedThing regulation of respiratory gaseous exchange by nervous system process A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates. got7fsn_ti neurological control of breathing|regulation of respiratory gaseous exchange by neurological system process biological_process owl:Class
GO:0106226 biolink:NamedThing peptide 2-hydroxyisobutyryltransferase activity Catalysis of the reaction: 2-hydroxyisobutyryl-CoA + lysine in peptide = CoA + N-2-hydroxyisobutyryl-lysine-peptide. got7fsn_ti hjd 2019-10-17T18:55:24Z RHEA:24180 molecular_function owl:Class
GO:0004397 biolink:NamedThing histidine ammonia-lyase activity Catalysis of the reaction: L-histidine = urocanate + NH3. got7fsn_ti L-histidine ammonia-lyase (urocanate-forming)|histidase activity|histidinase activity|histidine alpha-deaminase activity|L-histidine ammonia-lyase activity EC:4.3.1.3|MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN|RHEA:21232|Reactome:R-HSA-70899 molecular_function owl:Class
GO:0075218 biolink:NamedThing zoospore encystment on host The physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0071322 biolink:NamedThing cellular response to carbohydrate stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus. got7fsn_ti mah 2009-12-10T05:13:33Z biological_process owl:Class
GO:0102091 biolink:NamedThing phosphatidylinositol-5-phosphate 5-phosphatase activity Catalysis of the reaction: H2O + a 1-phosphatidyl-1D-myo-inositol 5-phosphate = hydrogenphosphate + an L-1-phosphatidyl-inositol. got7fsn_ti MetaCyc:RXN-10962 molecular_function owl:Class
GO:0016015 biolink:NamedThing morphogen activity Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. got7fsn_ti molecular_function owl:Class
GO:0007198 biolink:NamedThing adenylate cyclase-inhibiting serotonin receptor signaling pathway The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP). got7fsn_ti serotonin receptor, adenylyl cyclase inhibiting pathway|inhibition of adenylate cyclase activity by serotonin receptor signaling pathway|serotonin receptor, adenylate cyclase inhibiting pathway|inhibition of adenylate cyclase activity by serotonin receptor signalling pathway biological_process owl:Class
GO:0036291 biolink:NamedThing protein cis-autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues. got7fsn_ti cis-autophosphorylation bf 2012-07-18T10:27:06Z biological_process owl:Class
GO:0060640 biolink:NamedThing positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling Any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud. got7fsn_ti positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signaling|positive regulation of dentine-containing tooth bud formation by mesenchymal-epithelial signalling dph 2009-05-20T04:33:52Z biological_process owl:Class
GO:0042488 biolink:NamedThing positive regulation of odontogenesis of dentin-containing tooth Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates. got7fsn_ti upregulation of odontogenesis|activation of odontogenesis|positive regulation of odontogenesis of dentine-containing teeth|positive regulation of odontogenesis of dentine-containing tooth|up regulation of odontogenesis|stimulation of odontogenesis|up-regulation of odontogenesis biological_process owl:Class
GO:0010128 biolink:NamedThing benzoate catabolic process via CoA ligation The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway. got7fsn_ti anaerobic benzoate degradation|anaerobic benzoate breakdown|anaerobic benzoate catabolic process|anaerobic benzoate catabolism MetaCyc:PWY-283 biological_process owl:Class
GO:0070994 biolink:NamedThing detection of oxidative stress The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal. got7fsn_ti mah 2009-10-30T02:54:35Z biological_process owl:Class
GO:1990002 biolink:NamedThing methylglyoxal reductase (NADPH-dependent, acetol producing) Catalysis of the reaction: H+ + methylglyoxal + NADPH <=> hydroxyacetone + NADP+. got7fsn_ti jl 2012-12-05T15:55:06Z RHEA:27986 molecular_function owl:Class
GO:1990053 biolink:NamedThing DNA-5-methylcytosine glycosylase activity Catalysis of the reaction: DNA containing 5-methylcytosine + H2O = DNA with abasic site + 5-methylcytosine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the DNA 5-methylcytosine and the deoxyribose sugar to remove the 5-methylcytosine, leaving an abasic site. got7fsn_ti tb 2013-02-22T01:09:06Z molecular_function owl:Class
GO:0019768 biolink:NamedThing high-affinity IgE receptor activity Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti high affinity IgE receptor activity|high affinity Fc receptor activity molecular_function owl:Class
GO:0051734 biolink:NamedThing polynucleotide kinase activity Catalysis of the reaction: ATP + 5'-dephosphopolynucleotide = ADP + 5'-phosphopolynucleotide. The polynucleotide may be DNA or RNA. got7fsn_ti ATP-dependent polynucleotide kinase activity|ATP-dependent polynucleotide 5'-hydroxyl-kinase activity|ATP:5'-dephosphopolynucleotide 5'-phosphotransferase activity|ATP:5'-dephosphopolynucleotide 5'-phosphatase activity https://github.com/geneontology/go-ontology/issues/21619 EC:2.7.1.78|RHEA:54580 molecular_function owl:Class
GO:0016131 biolink:NamedThing brassinosteroid metabolic process The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. got7fsn_ti brassinosteroid metabolism biological_process owl:Class
GO:0102328 biolink:NamedThing 3-oxoacid decarboxylase activity Catalysis of the reaction: H+ + a 3-oxoacid = carbon dioxide + a methylketone. got7fsn_ti MetaCyc:RXN-13248 molecular_function owl:Class
GO:0047825 biolink:NamedThing D-lactate-2-sulfatase activity Catalysis of the reaction: (R)-2-O-sulfolactate + H(2)O = (R)-lactate + H(+) + sulfate. got7fsn_ti (S)-2-O-sulfolactate 2-sulfohydrolase activity|D-lactate-2-sulphatase activity KEGG_REACTION:R01448|RHEA:20337|MetaCyc:D-LACTATE-2-SULFATASE-RXN|EC:3.1.6.17 molecular_function owl:Class
GO:0102586 biolink:NamedThing cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6''-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside] sinapoyltransferase activity Catalysis of the reaction: cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-malonylglucoside + 1-O-sinapoyl-beta-D-glucose <=> cyanidin 3-O-[2''-O-(2''-O-(sinapoyl) xylosyl) 6'-O-(p-coumaroyl) glucoside] 5-O-[6''-O-(malonyl) glucoside + beta-D-glucose. got7fsn_ti MetaCyc:RXN-15332 molecular_function owl:Class
GO:0004344 biolink:NamedThing glucose dehydrogenase activity Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor. got7fsn_ti D-glucose:acceptor 1-oxidoreductase|glucose dehydrogenase (Aspergillus) activity|glucose dehydrogenase (acceptor) activity|glucose dehydrogenase (decarboxylating)|D-glucose:(acceptor) 1-oxidoreductase GO:0008708 RHEA:24540|MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN|EC:1.1.99.10|KEGG_REACTION:R00305 molecular_function owl:Class
GO:0047608 biolink:NamedThing acetylindoxyl oxidase activity Catalysis of the reaction: N-acetylindoxyl + O2 = N-acetylisatin + unknown. got7fsn_ti N-acetylindoxyl:oxygen oxidoreductase activity MetaCyc:ACETYLINDOXYL-OXIDASE-RXN|RHEA:16941|EC:1.7.3.2 molecular_function owl:Class
GO:0016977 biolink:NamedThing chitosanase activity Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan. got7fsn_ti chitosan N-acetylglucosaminohydrolase activity MetaCyc:3.2.1.132-RXN|EC:3.2.1.132 molecular_function owl:Class
GO:0044715 biolink:NamedThing 8-oxo-dGDP phosphatase activity Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate. got7fsn_ti jl 2012-10-18T13:31:09Z RHEA:32063|Reactome:R-HSA-2395879|EC:3.6.1.58|Reactome:R-HSA-2395873 molecular_function owl:Class
GO:0031694 biolink:NamedThing alpha-2A adrenergic receptor binding Binding to an alpha-2A adrenergic receptor. got7fsn_ti alpha-2A adrenergic receptor ligand molecular_function owl:Class
GO:0010934 biolink:NamedThing macrophage cytokine production The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0016339 biolink:NamedThing calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. got7fsn_ti calcium-dependent cell adhesion molecule activity biological_process owl:Class
GO:1990600 biolink:NamedThing single-stranded DNA endodeoxyribonuclease activator activity Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity. got7fsn_ti al 2015-01-06T15:35:36Z molecular_function owl:Class
GO:0033882 biolink:NamedThing choloyl-CoA hydrolase activity Catalysis of the reaction: choloyl-CoA + H2O = cholate + CoA. got7fsn_ti choloyl-coenzyme A thioesterase activity|PTE-2|peroxisomal acyl-CoA thioesterase 2 activity|chenodeoxycholoyl-coenzyme A thioesterase activity EC:3.1.2.27|RHEA:14541|MetaCyc:3.1.2.27-RXN molecular_function owl:Class
GO:0016973 biolink:NamedThing poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. got7fsn_ti polyadenylated mRNA export from nucleus|poly(A)+ mRNA transport from nucleus to cytoplasm|poly(A)+ mRNA export out of nucleus|poly(A)+ mRNA export from cell nucleus|poly(A)+ mRNA-nucleus export|poly(A) mRNA export from nucleus biological_process owl:Class
GO:0032942 biolink:NamedThing inositol tetrakisphosphate 2-kinase activity Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP. got7fsn_ti inositol-tetrakisphosphate 2-kinase activity|inositol 1,3,4,6-tetrakisphosphate 2-kinase activity|1D-myo-inositol-tetrakisphosphate 2-kinase activity EC:2.7.1.- molecular_function owl:Class
GO:0036067 biolink:NamedThing light-dependent chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light. got7fsn_ti light-dependent chlorophyll biosynthesis|light-dependent chlorophyll formation|light-dependent chlorophyll anabolism|light dependent chlorophyll biosynthetic process|light-dependent chlorophyll synthesis bf 2011-12-15T04:42:47Z biological_process owl:Class
GO:0044210 biolink:NamedThing 'de novo' CTP biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. got7fsn_ti 'de novo' cytidine 5'-triphosphate biosynthetic process jl 2009-10-22T03:22:34Z biological_process owl:Class
GO:0006241 biolink:NamedThing CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. got7fsn_ti CTP formation|CTP anabolism|CTP biosynthesis|CTP synthesis biological_process owl:Class
GO:0002479 biolink:NamedThing antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules. got7fsn_ti cross-presentation|exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent|cross presentation|TAP-dependent exogenous peptide antigen processing and presentation via MHC class I|TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process owl:Class
GO:0004588 biolink:NamedThing orotate phosphoribosyltransferase activity Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. got7fsn_ti OPRTase activity|orotidine 5'-monophosphate pyrophosphorylase activity|orotidylate pyrophosphorylase activity|orotidylic pyrophosphorylase activity|OPRT activity|orotic acid phosphoribosyltransferase activity|orotidylic acid pyrophosphorylase activity|orotidylic phosphorylase activity|orotidylic acid phosphorylase activity|orotidine monophosphate pyrophosphorylase activity|orotidine-5'-phosphate pyrophosphorylase activity|orotidine-5'-phosphate diphosphorylase activity|orotidine phosphoribosyltransferase activity|orotidylate phosphoribosyltransferase activity|orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity|orotate phosphoribosyl pyrophosphate transferase activity MetaCyc:OROPRIBTRANS-RXN|RHEA:10380|Reactome:R-HSA-73567|EC:2.4.2.10 molecular_function owl:Class
GO:0036344 biolink:NamedThing platelet morphogenesis Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. got7fsn_ti bf 2012-09-11T15:15:35Z biological_process owl:Class
GO:0050515 biolink:NamedThing 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H(+). got7fsn_ti CDP-ME kinase activity|ATP:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol 2-phosphotransferase activity|4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity|4-diphosphocytidyl-2-C-methyl-D-erythritol kinase activity|CMK activity GO:0008698 KEGG_REACTION:R05634|EC:2.7.1.148|MetaCyc:2.7.1.148-RXN|RHEA:18437 molecular_function owl:Class
GO:0046595 biolink:NamedThing establishment of pole plasm mRNA localization Any process that results in the directed movement of mRNA to the oocyte pole plasm. got7fsn_ti establishment of oocyte pole plasm mRNA localization|establishment of pole plasm mRNA localisation GO:0048121 biological_process owl:Class
GO:0047626 biolink:NamedThing adenosylmethionine hydrolase activity Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O = S-methyl-5'-thioadenosine + L-homoserine + H(+). got7fsn_ti adenosylmethionine lyase activity|methylmethionine-sulfonium-salt hydrolase activity|S-adenosyl-L-methionine hydrolase activity|S-adenosylmethionine cleaving enzyme activity|adenosyl methionine hydrolase activity MetaCyc:ADENOSYLMETHIONINE-HYDROLASE-RXN|KEGG_REACTION:R00175|EC:3.3.1.2|RHEA:14645 molecular_function owl:Class
GO:0099400 biolink:NamedThing caveola neck A membrane microdomain that forms a necklace around the bulb (crater) of a caveola. Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it. got7fsn_ti cellular_component owl:Class
GO:0019464 biolink:NamedThing glycine decarboxylation via glycine cleavage system The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. got7fsn_ti glycine cleavage system MetaCyc:GLYCLEAV-PWY biological_process owl:Class
GO:0006546 biolink:NamedThing glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. got7fsn_ti glycine breakdown|glycine catabolism|glycine degradation biological_process owl:Class
GO:0102123 biolink:NamedThing gibberellin A4 16alpha,17 epoxidase activity Catalysis of the reaction: gibberellin A4 + O2 + H+ + NAD(P)H <=> 16alpha,17-epoxy gibberellin A4 + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-11385 molecular_function owl:Class
GO:0004461 biolink:NamedThing lactose synthase activity Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose. got7fsn_ti uridine diphosphogalactose-glucose galactosyltransferase activity|UDPgalactose:D-glucose 4-beta-D-galactotransferase activity|lactose synthetase activity|UDP-galactose:D-glucose 4-beta-D-galactotransferase activity|UDPgalactose-glucose galactosyltransferase activity|UDP-galactose-glucose galactosyltransferase activity RHEA:12404|EC:2.4.1.22|MetaCyc:LACTOSE-SYNTHASE-RXN|Reactome:R-HSA-5653878 molecular_function owl:Class
GO:0035046 biolink:NamedThing pronuclear migration The directed movement of the male and female pronuclei towards each other prior to their fusion. got7fsn_ti biological_process owl:Class
GO:0052712 biolink:NamedThing inositol phosphosphingolipid phospholipase activity Catalysis of the reaction: inositol phosphosphingolipid + H2O = sphingolipid + phosphorylinositol. got7fsn_ti ai 2011-08-05T04:49:13Z molecular_function owl:Class
GO:0005668 biolink:NamedThing RNA polymerase transcription factor SL1 complex A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48. got7fsn_ti selectivity factor SL1 complex|TIF-IB cellular_component owl:Class
GO:0102955 biolink:NamedThing S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H+. got7fsn_ti EC:2.1.1.163|RHEA:33255|MetaCyc:RXN-9191 molecular_function owl:Class
GO:0102358 biolink:NamedThing daphnetin-8-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 7,8-dihydroxycoumarin <=> S-adenosyl-L-homocysteine + 7-hydroxy-8-methoxycoumarin + H+. got7fsn_ti MetaCyc:RXN-13448 molecular_function owl:Class
GO:0106146 biolink:NamedThing sideretin biosynthesis The chemical reactions and pathways resulting in the formation of sideretin. got7fsn_ti hjd 2018-09-07T18:31:30Z biological_process owl:Class
GO:0032442 biolink:NamedThing phenylcoumaran benzylic ether reductase activity Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+. got7fsn_ti PCBER activity molecular_function owl:Class
GO:0060002 biolink:NamedThing plus-end directed microfilament motor activity A motor activity that generates movement along a microfilament towards the plus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers. got7fsn_ti plus-end directed actin-filament motor activity|barbed-end directed actin-filament motor activity|plus-end directed actin filament motor activity molecular_function owl:Class
GO:0043700 biolink:NamedThing pterinosome A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance. got7fsn_ti cellular_component owl:Class
GO:0047060 biolink:NamedThing (R)-pantolactone dehydrogenase (flavin) activity Catalysis of the reaction: (R)-pantolactone + A = 2-dehydropantolactone + AH(2). got7fsn_ti (R)-pantolactone:acceptor oxidoreductase (flavin-containing)|2-dehydropantoyl-lactone reductase (flavin) activity|(R)-pantoyllactone dehydrogenase (flavin) activity|2-dehydropantolactone reductase (flavin) activity KEGG_REACTION:R03156|EC:1.1.99.27|RHEA:21004|MetaCyc:1.1.99.27-RXN molecular_function owl:Class
GO:0050152 biolink:NamedThing omega-amidase activity Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3. got7fsn_ti w-amidase activity|alpha-keto acid-omega-amidase activity|omega-amidodicarboxylate amidohydrolase activity MetaCyc:OMEGA-AMIDASE-RXN|RHEA:11716|EC:3.5.1.3 molecular_function owl:Class
GO:0017118 biolink:NamedThing lipoyltransferase activity Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme. got7fsn_ti RHEA:20473 molecular_function owl:Class
GO:0034347 biolink:NamedThing type III interferon binding Binding to a type III interferon. Interferon lambda is the only member of the type III interferon found so far. got7fsn_ti interferon-lambda binding Note that IL-28A, IL-28B, and IL-29 are types of interferon-lambda. molecular_function owl:Class
GO:0072499 biolink:NamedThing photoreceptor cell axon guidance The chemotaxis process that directs the migration of a photoreceptor cell axon growth cone to its target in the optic lobe in response to a combination of attractive and repulsive cues. got7fsn_ti photoreceptor cell axon pathfinding mah 2010-12-15T05:34:10Z biological_process owl:Class
GO:0061258 biolink:NamedThing mesonephric glomerular visceral epithelial cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a mesonephric glomerular visceral epithelial cell. A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros. got7fsn_ti dph 2010-08-30T02:13:33Z biological_process owl:Class
GO:0060814 biolink:NamedThing posterior mRNA localization involved in anterior/posterior axis specification Any process in which a mRNA is transported to and maintained in the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis. got7fsn_ti posterior mRNA localisation involved in anterior/posterior axis specification dph 2009-08-07T09:54:54Z biological_process owl:Class
GO:0010471 biolink:NamedThing GDP-galactose:mannose-1-phosphate guanylyltransferase activity Catalysis of the reaction: GDP-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + alpha-L-galactose-1-phosphate. got7fsn_ti GDP-L-galactose phosphorylase activity|GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity MetaCyc:RXN4FS-12 molecular_function owl:Class
GO:0047494 biolink:NamedThing serine-phosphoethanolamine synthase activity Catalysis of the reaction: L-serine + CDP-ethanolamine = L-serine-phosphoethanolamine + CMP + H(+). got7fsn_ti serine-phosphinico-ethanolamine synthase activity|serine ethanolaminephosphotransferase activity|CDP-ethanolamine:L-serine ethanolamine phosphotransferase activity|serine ethanolamine phosphodiester synthase activity|serine ethanolamine phosphate synthetase activity|serinephosphoethanolamine synthase activity KEGG_REACTION:R02563|MetaCyc:SERINE-PHOSPHOETHANOLAMINE-SYNTHASE-RXN|EC:2.7.8.4|RHEA:22656 molecular_function owl:Class
GO:0009996 biolink:NamedThing negative regulation of cell fate specification Any process that restricts, stops or prevents a cell from adopting a specific cell fate. got7fsn_ti down-regulation of cell fate specification|downregulation of cell fate specification|down regulation of cell fate specification|inhibition of cell fate specification|suppression of cell fate biological_process owl:Class
GO:0009551 biolink:NamedThing secondary plasmodesma A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata. got7fsn_ti cellular_component owl:Class
GO:0072665 biolink:NamedThing protein localization to vacuole A process in which a protein is transported to, or maintained at, a location in a vacuole. got7fsn_ti protein localisation to vacuole mah 2011-02-14T02:55:35Z biological_process owl:Class
GO:0043338 biolink:NamedThing CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol. got7fsn_ti CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase RHEA:25690|EC:2.7.7.67 molecular_function owl:Class
GO:0034676 biolink:NamedThing integrin alpha6-beta4 complex An integrin complex that comprises one alpha6 subunit and one beta4 subunit. got7fsn_ti alpha6-beta4 integrin complex|ITGA6-ITGB4 complex cellular_component owl:Class
GO:0006856 biolink:NamedThing eye pigment precursor transport The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0047236 biolink:NamedThing methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity Catalysis of the reaction: methylazoxymethanol + UDP-D-glucose = H+ + cycasin + UDP. got7fsn_ti methyl-ONN-azoxymethanol glucosyltransferase activity|UDP-glucose:methyl-ONN-azoxymethanol beta-D-glucosyltransferase activity|UDPglucose-methylazoxymethanol glucosyltransferase activity|cycasin synthase activity|uridine diphosphoglucose-methylazoxymethanol glucosyltransferase activity RHEA:20205|MetaCyc:2.4.1.171-RXN|EC:2.4.1.171 molecular_function owl:Class
GO:0102945 biolink:NamedThing soyasapogenol B UDP-glucosyl transferase activity Catalysis of the reaction: UDP-alpha-D-glucose(2-) + soyasapogenol B <=> UDP(3-) + a soyasapogenol B monoglucoside. got7fsn_ti MetaCyc:RXN-9037 molecular_function owl:Class
GO:0102141 biolink:NamedThing [chondroitin sulfate]-D-glucuronyl 2-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [chondroitin-sulfate]-beta-D-glucuronate = adenosine 3',5'-bismonophosphate + [chondroitin-sulfate]-2-O-sulfo-beta-D-glucuronate. got7fsn_ti MetaCyc:RXN-11560 molecular_function owl:Class
GO:0002316 biolink:NamedThing follicular B cell differentiation The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region. got7fsn_ti follicular B-cell differentiation|follicular B cell development|follicular B lymphocyte differentiation|follicular B-lymphocyte differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0047196 biolink:NamedThing long-chain-alcohol O-fatty-acyltransferase activity Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA. got7fsn_ti wax-ester synthase activity|wax ester synthase activity|wax synthase activity|acyl-CoA:long-chain-alcohol O-acyltransferase activity GO:0103095 Reactome:R-HSA-5696424|MetaCyc:RXNQT-4193|Reactome:R-HSA-8848582|MetaCyc:2.3.1.75-RXN|RHEA:38443|EC:2.3.1.75 molecular_function owl:Class
GO:0033936 biolink:NamedThing polymannuronate hydrolase activity Catalysis of the endohydrolysis of the D-mannuronide linkages of polymannuronate. got7fsn_ti poly(mannuronide) mannuronohydrolase activity|polymannuronic acid polymerase activity MetaCyc:3.2.1.121-RXN|EC:3.2.1.121 molecular_function owl:Class
GO:0090269 biolink:NamedThing fibroblast growth factor production The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti tb 2010-02-05T02:33:33Z biological_process owl:Class
GO:0003866 biolink:NamedThing 3-phosphoshikimate 1-carboxyvinyltransferase activity Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate. got7fsn_ti 5-enolpyruvylshikimate-3-phosphate synthase activity|3-enol-pyruvoylshikimate-5-phosphate synthase activity|phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity|EPSP synthase activity KEGG_REACTION:R03460|EC:2.5.1.19|RHEA:21256|MetaCyc:2.5.1.19-RXN molecular_function owl:Class
GO:0102522 biolink:NamedThing tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 4-demethylwyosine37 in tRNAPhe <=> 5'-S-methyl-5'-thioadenosine + H+ + 7-[(3S)-3-amino-3-carboxypropyl]-4-demethylwyosine37 in tRNAPhe. got7fsn_ti MetaCyc:RXN-14518|RHEA:36355|EC:2.5.1.114 molecular_function owl:Class
GO:0018543 biolink:NamedThing 4-amino-2-nitroso-6-nitrotoluene reductase activity Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene. got7fsn_ti UM-BBD_reactionID:r0464 molecular_function owl:Class
GO:0072703 biolink:NamedThing cellular response to methyl methanesulfonate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus. got7fsn_ti cellular response to MMS mah 2012-04-11T03:04:18Z biological_process owl:Class
GO:0008071 biolink:NamedThing maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster. got7fsn_ti maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded|maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded|maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded biological_process owl:Class
GO:0030254 biolink:NamedThing protein secretion by the type III secretion system The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins. got7fsn_ti type III protein secretion system|protein secretion by the T3SS|protein secretion by the T3S|protein secretion by the type III protein secretion system|protein secretion by the TTSS Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. biological_process owl:Class
GO:0010406 biolink:NamedThing classical arabinogalactan protein metabolic process The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored. got7fsn_ti classical-arabinogalactan protein metabolism biological_process owl:Class
GO:0021906 biolink:NamedThing hindbrain-spinal cord boundary formation The process whose specific outcome is the formation of the hindbrain-spinal cord boundary. got7fsn_ti biological_process owl:Class
GO:0021666 biolink:NamedThing rhombomere 5 formation The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0004687 biolink:NamedThing myosin light chain kinase activity Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate. got7fsn_ti ATP:myosin-light-chain O-phosphotransferase|smooth-muscle-myosin-light-chain kinase activity|calcium/calmodulin-dependent myosin light chain kinase activity|ATP:myosin-light-chain O-phosphotransferase activity|myosin light chain protein kinase activity|myosin light-chain kinase (phosphorylating)|MLCK|myosin light-chain kinase|myosin kinase activity|MLCkase activity|myosin light-chain kinase activity|myosin-light-chain kinase activity|myosin light-chain kinase (phosphorylating) activity|STK18 EC:2.7.11.18|Reactome:R-HSA-445813|Reactome:R-HSA-5668978|RHEA:22004|MetaCyc:2.7.11.18-RXN molecular_function owl:Class
GO:0050838 biolink:NamedThing peptidyl-5-hydroxy-L-lysine trimethylation The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine. got7fsn_ti RESID:AA0359 biological_process owl:Class
GO:0106009 biolink:NamedThing (4S)-4-hydroxy-2-oxoglutarate aldolase activity Catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate. got7fsn_ti hjd 2017-04-25T14:14:58Z RHEA:35639|EC:4.1.3.42 molecular_function owl:Class
GO:0047858 biolink:NamedThing dihydroxyfumarate decarboxylase activity Catalysis of the reaction: dihydroxyfumarate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2). got7fsn_ti dihydroxyfumarate carboxy-lyase activity|dihydroxyfumarate carboxy-lyase (tartronate-semialdehyde-forming) RHEA:13845|KEGG_REACTION:R03127|EC:4.1.1.54|MetaCyc:DIHYDROXYFUMARATE-DECARBOXYLASE-RXN molecular_function owl:Class
GO:0036405 biolink:NamedThing anchored component of cell outer membrane The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. got7fsn_ti anchored to cell outer membrane bf 2013-08-15T11:40:41Z cellular_component owl:Class
GO:0072187 biolink:NamedThing metanephric cap formation The developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip. got7fsn_ti mah 2010-03-01T01:26:53Z biological_process owl:Class
GO:0050044 biolink:NamedThing galactose-6-phosphate isomerase activity Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate. got7fsn_ti D-galactose-6-phosphate ketol-isomerase activity|D-galactose-6-phosphate aldose-ketose-isomerase activity EC:5.3.1.26|RHEA:13033|MetaCyc:LACTOSE-6-PHOSPHATE-ISOMERASE-RXN|KEGG_REACTION:R03240 molecular_function owl:Class
GO:0071257 biolink:NamedThing cellular response to electrical stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. got7fsn_ti cellular response to electricity mah 2009-12-04T03:27:03Z biological_process owl:Class
GO:0047468 biolink:NamedThing phosphoglucomutase (glucose-cofactor) activity Catalysis of the reaction: glucose-1-phosphate = glucose-6-phosphate; using D-glucose as a cofactor. got7fsn_ti alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)|glucose-1-phosphate phosphotransferase activity MetaCyc:5.4.2.5-RXN|EC:5.4.2.5 molecular_function owl:Class
GO:0004614 biolink:NamedThing phosphoglucomutase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate. got7fsn_ti glucose phosphomutase activity|phosphoglucose mutase activity|alpha-D-glucose 1,6-phosphomutase activity Reactome:R-HSA-9638125|Reactome:R-HSA-9638127|Reactome:R-HSA-5609939|Reactome:R-HSA-70272|MetaCyc:PHOSPHOGLUCMUT-RXN|Reactome:R-HSA-70427|RHEA:23536|EC:5.4.2.2 molecular_function owl:Class
GO:0060577 biolink:NamedThing pulmonary vein morphogenesis The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart. got7fsn_ti pulmonary venous blood vessel morphogenesis dph 2009-05-06T08:44:04Z biological_process owl:Class
GO:0035156 biolink:NamedThing fusion cell fate specification The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion. got7fsn_ti biological_process owl:Class
GO:0010187 biolink:NamedThing negative regulation of seed germination Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination. got7fsn_ti inhibition of seed germination|down-regulation of seed germination|down regulation of seed germination|downregulation of seed germination biological_process owl:Class
GO:0030971 biolink:NamedThing receptor tyrosine kinase binding Binding to a receptor that possesses protein tyrosine kinase activity. got7fsn_ti transmembrane receptor protein tyrosine kinase ligand binding molecular_function owl:Class
GO:1990782 biolink:NamedThing protein tyrosine kinase binding Binding to protein tyrosine kinase. got7fsn_ti tyrosine kinase binding sl 2015-06-23T20:50:58Z molecular_function owl:Class
GO:0030739 biolink:NamedThing O-demethylpuromycin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin. got7fsn_ti O-demethylpuromycin methyltransferase activity|S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity RHEA:22280|EC:2.1.1.38|MetaCyc:2.1.1.38-RXN molecular_function owl:Class
GO:0047640 biolink:NamedThing aldose 1-dehydrogenase activity Catalysis of the reaction: D-aldose + NAD+ = D-aldonolactone + NADH. got7fsn_ti aldose dehydrogenase activity|D-aldose:NAD+ 1-oxidoreductase activity|dehydrogenase, D-aldohexose MetaCyc:ALDOSE-1-DEHYDROGENASE-RXN|EC:1.1.1.121|RHEA:15917 molecular_function owl:Class
GO:0071894 biolink:NamedThing histone H2B conserved C-terminal lysine ubiquitination A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals. got7fsn_ti fission yeast H2B K119 ubiquitination|budding yeast H2B K123 ubiquitination|mammalian H2B K120 ubiquitination mah 2010-09-14T03:43:46Z biological_process owl:Class
GO:0033523 biolink:NamedThing histone H2B ubiquitination The modification of histone H2B by addition of ubiquitin groups. got7fsn_ti biological_process owl:Class
GO:0006554 biolink:NamedThing lysine catabolic process The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid. got7fsn_ti lysine catabolism|lysine degradation|lysine breakdown biological_process owl:Class
GO:0102715 biolink:NamedThing gibberellin A17,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A17 + 2-oxoglutarate + O2 <=> gibberellin A28 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-6546 molecular_function owl:Class
GO:0052820 biolink:NamedThing DNA-1,N6-ethenoadenine N-glycosylase activity Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. got7fsn_ti 1,N(6)-ethenoadenine N-glycosylase activity|1,N6-ethenoadenine glycosylase activity 2011-10-28T01:17:21Z molecular_function owl:Class
GO:0102361 biolink:NamedThing esculetin 4-O-beta-glucosyltransferase activity Catalysis of the reaction: esculetin + UDP-alpha-D-glucose <=> 4-O-beta-D-glucosyl-esculetin + UDP + H+. got7fsn_ti EC:2.4.1.126|MetaCyc:RXN-13471 molecular_function owl:Class
GO:0008977 biolink:NamedThing prephenate dehydrogenase (NAD+) activity Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH. got7fsn_ti chorismate mutase--prephenate dehydrogenase activity|hydroxyphenylpyruvate synthase activity|prephenate:NAD+ oxidoreductase (decarboxylating) KEGG_REACTION:R01728|MetaCyc:PREPHENATEDEHYDROG-RXN|EC:1.3.1.12|RHEA:13869 molecular_function owl:Class
GO:0140080 biolink:NamedThing class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity Catalysis of the cleavage of an AP site 3' and 5' of the baseless site, generating a 3'-phosphate and a 5'-OH. got7fsn_ti endonuclease III|endonuclease IV pg 2017-07-24T11:48:18Z molecular_function owl:Class
GO:1900791 biolink:NamedThing shamixanthone metabolic process The chemical reactions and pathways involving shamixanthone. got7fsn_ti shamixanthone metabolism di 2012-06-04T09:40:20Z biological_process owl:Class
GO:0075285 biolink:NamedThing sexual sporulation resulting in formation of a multicellular or syncytial spore The formation of multicellular or syncytial spore via septations derived from meiosis. A multicellular or syncytial spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction. got7fsn_ti biological_process owl:Class
GO:0047277 biolink:NamedThing globoside alpha-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-N-acetyl-D-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide + UDP. got7fsn_ti globoside acetylgalactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase activity|forssman synthase activity|Forssman synthase activity|UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase activity MetaCyc:2.4.1.88-RXN|RHEA:22164|EC:2.4.1.88 molecular_function owl:Class
GO:0018528 biolink:NamedThing iminodiacetate dehydrogenase activity Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine. got7fsn_ti UM-BBD_reactionID:r0589 molecular_function owl:Class
GO:0019713 biolink:NamedThing peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine The coupled methyl esterification and deamidation of peptidyl-glutamine. got7fsn_ti peptidyl-L-glutamic acid 5-methyl ester formation from glutamine|peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine|peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine RESID:AA0072 biological_process owl:Class
GO:0098759 biolink:NamedThing cellular response to interleukin-8 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-8 stimulus. got7fsn_ti cellular response to IL-8 biological_process owl:Class
GO:0120178 biolink:NamedThing steroid hormone biosynthetic process The chemical reactions and pathways resulting in the formation of any steroid hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone. got7fsn_ti krc 2019-05-20T22:34:00Z biological_process owl:Class
GO:0016920 biolink:NamedThing pyroglutamyl-peptidase activity Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein. got7fsn_ti EC:3.4.19.- molecular_function owl:Class
GO:0008955 biolink:NamedThing peptidoglycan glycosyltransferase activity Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate. got7fsn_ti peptidoglycan transglycosylase activity|PG-II activity|bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity|undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity|peptidoglycan TGase activity|penicillin binding protein (3 or 1B) activity RHEA:23708|MetaCyc:RXN0-5405|EC:2.4.1.129 molecular_function owl:Class
GO:0097072 biolink:NamedThing interferon regulatory factor 3 complex An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3. got7fsn_ti IRF3:IRF3 complex pr 2011-06-15T04:26:10Z cellular_component owl:Class
GO:0090385 biolink:NamedThing phagosome-lysosome fusion The creation of a phagolysosome from a phagosome and a lysosome. got7fsn_ti tb 2010-10-27T10:24:28Z biological_process owl:Class
GO:0001882 biolink:NamedThing nucleoside binding Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. got7fsn_ti molecular_function owl:Class
GO:0008859 biolink:NamedThing exoribonuclease II activity Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction. got7fsn_ti RNase II|BN ribonuclease activity|Escherichia coli exo-RNase II|ribonuclease Q|ribonuclease II activity|5'-exoribonuclease activity|RNase II activity EC:3.1.13.1|MetaCyc:3.1.13.1-RXN molecular_function owl:Class
GO:0051865 biolink:NamedThing protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. got7fsn_ti protein self-ubiquitination|protein auto-ubiquitination|protein autoubiquitinylation|protein auto-ubiquitinylation|protein self-ubiquitinylation biological_process owl:Class
GO:0018848 biolink:NamedThing pinocarveol isomerase activity Catalysis of the reaction: pinocarveol = carveol. got7fsn_ti UM-BBD_reactionID:r0715|EC:5.5.1.- molecular_function owl:Class
GO:0071244 biolink:NamedThing cellular response to carbon dioxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus. got7fsn_ti mah 2009-12-03T02:41:21Z biological_process owl:Class
GO:0047079 biolink:NamedThing deoxyuridine 1'-dioxygenase activity Catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = 2-deoxy-D-ribono-1,4-lactone + CO(2) + succinate + uracil. got7fsn_ti pyrimidine-deoxynucleoside,2-oxoglutarate 1'-dioxygenase activity|2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (1'-hydroxylating)|pyrimidine-deoxynucleoside 1'-dioxygenase activity RHEA:23316|KEGG_REACTION:R02486|MetaCyc:1.14.11.10-RXN|EC:1.14.11.10 molecular_function owl:Class
GO:0014027 biolink:NamedThing secondary neural tube rod cavitation The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube. got7fsn_ti medullary rod cavitation biological_process owl:Class
GO:0102704 biolink:NamedThing GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity Catalysis of the reaction: GDP-alpha-D-mannose(2-) + a (mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol <=> H+ + GDP(3-) + a (mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol. got7fsn_ti RHEA:29519|MetaCyc:RXN-5463|EC:2.4.1.257 molecular_function owl:Class
GO:0016422 biolink:NamedThing mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am. got7fsn_ti S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity|S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity MetaCyc:2.1.1.62-RXN|EC:2.1.1.62|RHEA:22744 molecular_function owl:Class
GO:0008793 biolink:NamedThing aromatic-amino-acid:2-oxoglutarate aminotransferase activity Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate. got7fsn_ti aromatic amino acid transferase activity|aromatic amino acid aminotransferase activity|aromatic aminotransferase activity|ArAT|aromatic-amino-acid transaminase activity EC:2.6.1.57|RHEA:17533|UM-BBD_reactionID:r0297|MetaCyc:2.6.1.57-RXN molecular_function owl:Class
GO:0039557 biolink:NamedThing suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. got7fsn_ti inhibition of host IRF7 by virus|suppression by virus of host IRF7 activity|suppression by virus of host interferon regulatory factor 7 activity|inhibition of host interferon regulatory factor-7 by virus https://github.com/geneontology/go-ontology/issues/21985 This term is for annotation of viral proteins that counteract the host anti-viral innate immune response. bf 2012-03-09T04:17:46Z biological_process owl:Class
GO:0090653 biolink:NamedThing apical recycling endosome Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells. got7fsn_ti tb 2015-07-01T15:46:19Z cellular_component owl:Class
GO:0009337 biolink:NamedThing sulfite reductase complex (NADPH) A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide. got7fsn_ti sulphite reductase complex (NADPH) See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'. cellular_component owl:Class
GO:0009778 biolink:NamedThing cyclic photosynthetic phosphorylation A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I. got7fsn_ti biological_process owl:Class
GO:0047965 biolink:NamedThing glycoprotein O-fatty-acyltransferase activity Catalysis of the reaction: palmitoyl-CoA + mucus glycoprotein = CoA + O-palmitoylglycoprotein. got7fsn_ti fatty-acyl-CoA:mucus-glycoprotein fatty-acyltransferase activity|protein acyltransferase activity MetaCyc:GLYCOPROTEIN-O-FATTY-ACYLTRANSFERASE-RXN|EC:2.3.1.142 molecular_function owl:Class
GO:0018064 biolink:NamedThing protein-L-histidine N-tele-methyltransferase activity Catalysis of the reaction: L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine. got7fsn_ti protein (histidine) methyltransferase activity|S-adenosyl methionine:protein-histidine N-methyltransferase activity|S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity|protein-histidine N-methyltransferase activity|protein methylase IV activity|actin-specific histidine methyltransferase activity|peptidyl-histidine N-methyltransferase activity EC:2.1.1.85|RHEA:19369|MetaCyc:2.1.1.85-RXN molecular_function owl:Class
GO:0070080 biolink:NamedThing titin Z domain binding Binding to a titin Z protein domain, which recognizes and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34), adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. got7fsn_ti Z repeat domain binding molecular_function owl:Class
GO:0030761 biolink:NamedThing 8-hydroxyquercitin 8-O-methyltransferase activity Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+). got7fsn_ti flavonol 8-O-methyltransferase activity|S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity|flavonol 8-methyltransferase activity|8-hydroxyquercetin 8-O-methyltransferase activity MetaCyc:2.1.1.88-RXN|KEGG_REACTION:R04398|RHEA:16593|EC:2.1.1.88 molecular_function owl:Class
GO:0080095 biolink:NamedThing phosphatidylethanolamine-sterol O-acyltransferase activity Catalysis of the reaction: a phosphatidylethanolamine + a sterol = a sterol ester + a lysophosphatidylethanolamine. got7fsn_ti dhl 2009-04-23T03:39:33Z molecular_function owl:Class
GO:0019377 biolink:NamedThing glycolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). got7fsn_ti glycolipid breakdown|glycolipid degradation|glycolipid catabolism biological_process owl:Class
GO:0030581 biolink:NamedThing symbiont intracellular protein transport in host The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti intracellular protein transport in other organism during symbiotic interaction|intracellular protein transport in other organism involved in symbiotic interaction|intracellular protein transport in host|host cell protein transport GO:0051708 biological_process owl:Class
GO:0070354 biolink:NamedThing GATA2-TAL1-TCF3-Lmo2 complex A protein complex that contains the zinc finger transcription factor GATA2, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis. got7fsn_ti cellular_component owl:Class
GO:0030960 biolink:NamedThing peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link. got7fsn_ti RESID:AA0368 biological_process owl:Class
GO:0016038 biolink:NamedThing absorption of visible light The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm. got7fsn_ti biological_process owl:Class
GO:0031301 biolink:NamedThing integral component of organelle membrane The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to organelle membrane cellular_component owl:Class
GO:0099085 biolink:NamedThing DIF dechlorinase activity Catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-. got7fsn_ti DIF-1 dechlorinase activity|1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one 3(5)-dechlorinase activity|DIF-1 3(5)-dechlorinase activity|differentiation-inducing factor 1 dechlorinase activity|1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one 3(5)-dechlorinase activity|differentiation-inducing factor dechlorinase activity molecular_function owl:Class
GO:0044290 biolink:NamedThing mitochondrial intracristal space The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space. got7fsn_ti jl 2010-02-04T02:32:10Z NIF_Subcellular:sao508958414 cellular_component owl:Class
GO:0034435 biolink:NamedThing cholesterol esterification A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle. got7fsn_ti biological_process owl:Class
GO:0008970 biolink:NamedThing phospholipase A1 activity Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. got7fsn_ti phosphatidylcholine 1-acylhydrolase activity RHEA:18689|Reactome:R-HSA-1482847|Reactome:R-HSA-1482920|Reactome:R-HSA-5694485|Reactome:R-HSA-1482862|MetaCyc:PHOSPHOLIPASE-A1-RXN|EC:3.1.1.32|Reactome:R-HSA-1482827|Reactome:R-HSA-1482932|Reactome:R-HSA-1482828|Reactome:R-HSA-1482892 molecular_function owl:Class
GO:0019333 biolink:NamedThing denitrification pathway The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen. got7fsn_ti MetaCyc:DENITRIFICATION-PWY biological_process owl:Class
GO:0033785 biolink:NamedThing heptose 7-phosphate kinase activity Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP. got7fsn_ti D-alpha,beta-D-heptose 7-phosphate 1-kinase activity RHEA:27473|MetaCyc:RXN0-4341|EC:2.7.1.167 molecular_function owl:Class
GO:1901694 biolink:NamedThing positive regulation of compound eye retinal cell apoptotic process Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process. got7fsn_ti up regulation of compound eye retinal cell apoptotic process|activation of compound eye retinal cell apoptotic process|up-regulation of compound eye retinal cell apoptotic process|induction of compound eye retinal cell programmed cell death|upregulation of compound eye retinal cell apoptotic process pr 2012-12-12T10:28:45Z GO:0046675 biological_process owl:Class
GO:0046672 biolink:NamedThing positive regulation of compound eye retinal cell programmed cell death Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina. got7fsn_ti up regulation of retinal cell programmed cell death|up-regulation of retinal cell programmed cell death|activation of retinal cell programmed cell death|stimulation of retinal cell programmed cell death|upregulation of retinal cell programmed cell death|positive regulation of retinal cell programmed cell death biological_process owl:Class
GO:0019930 biolink:NamedThing cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1. got7fsn_ti cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid|cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid|cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid RESID:AA0316 biological_process owl:Class
GO:0042769 biolink:NamedThing DNA damage response, detection of DNA damage The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal. got7fsn_ti detection of DNA damage during DNA damage response|DNA damage response, perception of DNA damage biological_process owl:Class
GO:0070311 biolink:NamedThing nucleosomal methylation activator complex A protein complex that contains eight subunits in common with the SWI/SNF complex, plus the ATPase BRG1 (SMARCA4) and the histone methyltransferase CARM1; the complex is involved in regulating nuclear receptor-dependent transcription. got7fsn_ti NUMAC cellular_component owl:Class
GO:0019273 biolink:NamedThing L-alanine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine. got7fsn_ti L-alanine synthesis via ornithine|L-alanine formation via ornithine|L-alanine anabolism via ornithine biological_process owl:Class
GO:0042852 biolink:NamedThing L-alanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid. got7fsn_ti L-alanine formation|L-alanine biosynthesis|L-alanine synthesis|L-alanine anabolism biological_process owl:Class
GO:0010674 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. got7fsn_ti negative regulation of transcription from RNA polymerase II promoter, meiotic|positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter|upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter|stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter|up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter|activation of meiosis by negative regulation of transcription from RNA polymerase II promoter|up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter dgf 2012-05-01T08:39:58Z GO:1900475 biological_process owl:Class
GO:0050408 biolink:NamedThing [pyruvate kinase]-phosphatase activity Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate. got7fsn_ti pyruvate kinase phosphatase activity|ATP:pyruvate 2-O-phosphotransferase-phosphate phosphohydrolase activity|pyruvate kinase-phosphatase activity EC:3.1.3.49|MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN molecular_function owl:Class
GO:1990352 biolink:NamedThing BRE1 E3 ubiquitin ligase complex A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes. got7fsn_ti BRE1 oligomer|BRE1 E3 ubiquitin-protein ligase complex An example of this is BRE1 in Saccharomyces cerevisiae (UniProt symbol Q07457) in PMID:19531475 (inferred from direct assay). bhm 2014-03-27T13:49:05Z cellular_component owl:Class
GO:0016608 biolink:NamedThing growth hormone-releasing hormone activity The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland. got7fsn_ti GHRH activity|GHRF activity molecular_function owl:Class
GO:0043481 biolink:NamedThing anthocyanin accumulation in tissues in response to UV light The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus. got7fsn_ti biological_process owl:Class
GO:0032264 biolink:NamedThing IMP salvage Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis. got7fsn_ti biological_process owl:Class
GO:0051991 biolink:NamedThing UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity Catalysis of the reaction: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + UDP. got7fsn_ti Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. ai 2010-07-06T11:53:19Z MetaCyc:NACGLCTRANS-RXN|RHEA:31227|EC:2.4.1.227 molecular_function owl:Class
GO:0033434 biolink:NamedThing AUC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AUC codon. got7fsn_ti ATC codon-amino acid adaptor activity|isoleucine tRNA Note that in the standard genetic code, ATC codes for isoleucine. molecular_function owl:Class
GO:0061007 biolink:NamedThing hepaticobiliary system process An system process carried out by any of the organs or tissues of the hepaticobiliary system. The hepaticobiliary system is responsible for metabolic and catabolic processing of small molecules absorbed from the blood or gut, hormones and serum proteins, detoxification, storage of glycogen, triglycerides, metals and lipid soluble vitamins and excretion of bile. Included are the synthesis of albumin, blood coagulation factors, complement, and specific binding proteins. got7fsn_ti hepatobiliary system process dph 2010-01-22T09:09:10Z biological_process owl:Class
GO:0071594 biolink:NamedThing thymocyte aggregation The adhesion of one thymocyte (an immature T cell) to one or more other thymocytes via adhesion molecules. got7fsn_ti immature T-cell aggregation|immature T cell aggregation|immature T-lymphocyte aggregation|thymic lymphocyte aggregation|T cell precursor aggregation mah 2010-01-29T01:38:49Z biological_process owl:Class
GO:0061865 biolink:NamedThing polarized secretion of basement membrane proteins in epithelium The basement membrane constituent secretion in which there is a restriction or targeting of basement membrane proteins for controlled release on the basal side of polarized epithelium. got7fsn_ti dph 2017-04-07T18:26:02Z biological_process owl:Class
GO:0018824 biolink:NamedThing (hydroxyamino)benzene mutase activity Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol. got7fsn_ti HAB mutase activity|hydroxylaminobenzene mutase activity|(hydroxyamino)benzene hydroxymutase activity|hydroxylaminobenzene hydroxymutase activity UM-BBD_reactionID:r0304|RHEA:19245|MetaCyc:5.4.4.1-RXN molecular_function owl:Class
GO:0071846 biolink:NamedThing actin filament debranching An actin filament severing process that results in the removal of actin filament branches specifically at the branch points. got7fsn_ti mah 2010-09-10T02:15:42Z biological_process owl:Class
GO:0051014 biolink:NamedThing actin filament severing The process in which an actin filament is broken down into smaller filaments. got7fsn_ti actin filament severing activity|F-actin severing|barbed-end actin capping/severing activity biological_process owl:Class
GO:0001717 biolink:NamedThing conversion of seryl-tRNAsec to selenocys-tRNAsec The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine. got7fsn_ti biological_process owl:Class
GO:0044066 biolink:NamedThing modification by symbiont of host cell nucleus The process in which a symbiont organism effects a change in the structure or function of its host cell nucleus. got7fsn_ti modification of host nucleus by symbiont|modification of host cell nucleus by symbiont|modification by symbiont of host nucleus biological_process owl:Class
GO:0045324 biolink:NamedThing late endosome to vacuole transport The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. got7fsn_ti biological_process owl:Class
GO:0052598 biolink:NamedThing histamine oxidase activity Catalysis of the reaction: histamine + H2O + O2 = imidazole-4-acetaldehyde + NH3 + hydrogen peroxide + H+. got7fsn_ti 1H-Imidazole-4-ethanamine oxidase activity|histamine:oxygen oxidoreductase (deaminating) activity|1H-Imidazole-4-ethanamine:oxygen oxidoreductase (deaminating) activity RHEA:25625|Reactome:R-HSA-5696131|EC:1.4.3.22|MetaCyc:RXN-9600|KEGG_REACTION:R02150 molecular_function owl:Class
GO:0090383 biolink:NamedThing phagosome acidification Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion. got7fsn_ti phagosomal acidification tb 2010-10-27T10:20:22Z biological_process owl:Class
GO:0046378 biolink:NamedThing enterobacterial common antigen metabolic process The chemical reactions and pathways involving enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria. got7fsn_ti enterobacterial common antigen metabolism biological_process owl:Class
GO:0102645 biolink:NamedThing 17(E)-cheilanthenediol synthase activity Catalysis of the reaction: 17(E)-cheilanthenediol <=> all-trans-geranylfarnesol + H2O. got7fsn_ti MetaCyc:RXN-15758 molecular_function owl:Class
GO:1990644 biolink:NamedThing microtubule site clamp The binding activity of a molecule that attaches the spindle microtubules to the kinetochore. got7fsn_ti vw 2015-02-13T15:50:13Z molecular_function owl:Class
GO:0044828 biolink:NamedThing negative regulation by host of viral genome replication A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication. got7fsn_ti jl 2014-02-06T11:34:23Z biological_process owl:Class
GO:0110055 biolink:NamedThing negative regulation of actin filament annealing Any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments. got7fsn_ti kmv 2017-09-20T20:10:55Z biological_process owl:Class
GO:0035492 biolink:NamedThing negative regulation of leukotriene production involved in inflammatory response Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. got7fsn_ti bf 2010-04-26T10:50:55Z biological_process owl:Class
GO:0047593 biolink:NamedThing 6-acetylglucose deacetylase activity Catalysis of the reaction: 6-acetyl-D-glucose + H(2)O = D-glucose + acetate + H(+). got7fsn_ti 6-acetyl-D-glucose acetylhydrolase activity|6-O-acetylglucose deacetylase activity EC:3.1.1.33|KEGG_REACTION:R00327|RHEA:18485|MetaCyc:6-ACETYLGLUCOSE-DEACETYLASE-RXN molecular_function owl:Class
GO:0006753 biolink:NamedThing nucleoside phosphate metabolic process The chemical reactions and pathways involving any phosphorylated nucleoside. got7fsn_ti nucleoside phosphate metabolism biological_process owl:Class
GO:0004561 biolink:NamedThing alpha-N-acetylglucosaminidase activity Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. got7fsn_ti NAG activity|alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity|alpha-D-2-acetamido-2-deoxyglucosidase activity|N-acetyl-alpha-glucosaminidase activity|N-acetyl-alpha-D-glucosaminidase activity|alpha-acetylglucosaminidase activity MetaCyc:3.2.1.50-RXN|EC:3.2.1.50|Reactome:R-HSA-2090038|Reactome:R-HSA-1678742|Reactome:R-HSA-9036052|Reactome:R-HSA-2263496 molecular_function owl:Class
GO:0097517 biolink:NamedThing contractile actin filament bundle An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle. got7fsn_ti pr 2013-10-16T15:41:14Z cellular_component owl:Class
GO:0006768 biolink:NamedThing biotin metabolic process The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. got7fsn_ti vitamin H metabolic process|vitamin H metabolism|biotin metabolism|vitamin B7 metabolism|vitamin B7 metabolic process Wikipedia:Biotin biological_process owl:Class
GO:0047160 biolink:NamedThing alkylglycerophosphate 2-O-acetyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycerol 3-phosphate + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + CoA. got7fsn_ti acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase activity|alkyllyso-GP:acetyl-CoA acetyltransferase activity MetaCyc:2.3.1.105-RXN|RHEA:18557|KEGG_REACTION:R03455|EC:2.3.1.105 molecular_function owl:Class
GO:0001586 biolink:NamedThing Gi/o-coupled serotonin receptor activity Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels. got7fsn_ti serotonin receptor activity, coupled via Gi/o|5-HT1 receptor activity molecular_function owl:Class
GO:0042139 biolink:NamedThing early meiotic recombination nodule assembly During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene. got7fsn_ti biological_process owl:Class
GO:0004494 biolink:NamedThing methylmalonyl-CoA mutase activity Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA. got7fsn_ti (R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity|methylmalonyl coenzyme A mutase activity|methylmalonyl-CoA CoA-carbonyl mutase activity|(R)-methylmalonyl-CoA CoA-carbonylmutase activity|methylmalonyl coenzyme A carbonylmutase activity|(S)-methylmalonyl-CoA mutase activity RHEA:22888|Reactome:R-HSA-3322971|Reactome:R-HSA-71010|KEGG_REACTION:R00833|EC:5.4.99.2|MetaCyc:METHYLMALONYL-COA-MUT-RXN|UM-BBD_reactionID:r0922 molecular_function owl:Class
GO:0034810 biolink:NamedThing 4,5-dihydroxybenzo(a)pyrene dioxygenase activity Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate. got7fsn_ti UM-BBD_reactionID:r1128|EC:1.13.11.- molecular_function owl:Class
GO:0004807 biolink:NamedThing triose-phosphate isomerase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. got7fsn_ti triose phosphate mutase activity|D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity|triose phosphoisomerase activity|triosephosphate mutase activity|D-glyceraldehyde-3-phosphate ketol-isomerase activity|phosphotriose isomerase activity|triosephosphate isomerase activity Reactome:R-HSA-70481|EC:5.3.1.1|MetaCyc:TRIOSEPISOMERIZATION-RXN|RHEA:18585|KEGG_REACTION:R01015|Reactome:R-HSA-70454 molecular_function owl:Class
GO:0002383 biolink:NamedThing immune response in brain or nervous system An immune response taking place in the brain or nervous system. got7fsn_ti biological_process owl:Class
GO:0016474 biolink:NamedThing sodium ion-transporting V-type ATPase complex A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. got7fsn_ti sodium-translocating V-type ATPase complex cellular_component owl:Class
GO:0006298 biolink:NamedThing mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. got7fsn_ti mismatch repair, MutL-like pathway|MMR|MutS/MutL/MutH pathway|long patch mismatch repair system GO:0006300 Wikipedia:DNA_mismatch_repair biological_process owl:Class
GO:0032408 biolink:NamedThing MutSbeta complex binding Binding to a MutSbeta mismatch repair complex. got7fsn_ti molecular_function owl:Class
GO:0004754 biolink:NamedThing saccharopine dehydrogenase (NAD+, L-lysine-forming) activity Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH. got7fsn_ti N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)|epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)|dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)|6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)|N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming) RHEA:12440|EC:1.5.1.7|KEGG_REACTION:R00715|MetaCyc:1.5.1.7-RXN molecular_function owl:Class
GO:0032281 biolink:NamedThing AMPA glutamate receptor complex An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. got7fsn_ti AMPA receptor|alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|AMPA-selective glutamate receptor complex cellular_component owl:Class
GO:0006425 biolink:NamedThing glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:2000075 biolink:NamedThing negative regulation of cytokinesis, site selection Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis. got7fsn_ti negative regulation of site selection involved in cell cycle cytokinesis tb 2010-08-27T11:19:56Z biological_process owl:Class
GO:0016756 biolink:NamedThing glutathione gamma-glutamylcysteinyltransferase activity Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly. got7fsn_ti glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity|phytochelatin synthase activity|gamma-glutamylcysteine dipeptidyl transpeptidase activity GO:0042143 EC:2.3.2.15|MetaCyc:2.3.2.15-RXN|RHEA:17917 molecular_function owl:Class
GO:0101011 biolink:NamedThing inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate 1-diphosphatase activity Catalysis of the reaction: myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = myo-inositol hexakisphosphate + phosphate. got7fsn_ti inositol 1-pyrophosphate 2,3,4,5,6-pentakisphosphate 1-pyrophosphatase activity molecular_function owl:Class
GO:0034683 biolink:NamedThing integrin alphav-beta3 complex An integrin complex that comprises one alphav subunit and one beta3 subunit. got7fsn_ti ITGAV-ITGB3 complex|alphav-beta3 integrin complex cellular_component owl:Class
GO:0043251 biolink:NamedThing sodium-dependent organic anion transport The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0015711 biolink:NamedThing organic anion transport The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. got7fsn_ti biological_process owl:Class
GO:0070514 biolink:NamedThing SRF-myogenin-E12 complex A transcription factor complex that contains the serum response factor (SRF) and the basic helix-loop-helix proteins myogenin and E12, and is involved in activating transcription of muscle-specific genes. got7fsn_ti cellular_component owl:Class
GO:0008257 biolink:NamedThing protein histidine tele-kinase activity Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine. got7fsn_ti ATP:protein-L-histidine Ntau-phosphotransferase activity|protein-histidine tele-kinase activity|ATP:protein-L-histidine N-tele-phosphotransferase activity|HK3 RHEA:11860|MetaCyc:2.7.13.2-RXN|EC:2.7.13.2 molecular_function owl:Class
GO:0002480 biolink:NamedThing antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules. got7fsn_ti TAP-independent exogenous peptide antigen processing and presentation via MHC class I|cross-presentation|cross presentation|exogenous peptide antigen processing and presentation via MHC class I, TAP-independent|TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I biological_process owl:Class
GO:0050410 biolink:NamedThing 3-oxolaurate decarboxylase activity Catalysis of the reaction: 3-oxolaurate + H(+) = 2-undecanone + CO(2). got7fsn_ti 3-oxododecanoate carboxy-lyase activity|beta-ketoacyl decarboxylase activity|beta-ketolaurate decarboxylase activity|3-oxododecanoate carboxy-lyase (2-undecanone-forming) MetaCyc:3-OXOLAURATE-DECARBOXYLASE-RXN|KEGG_REACTION:R03747|EC:4.1.1.56|RHEA:13385 molecular_function owl:Class
GO:0008683 biolink:NamedThing 2-oxoglutarate decarboxylase activity Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde. got7fsn_ti 2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)|alpha-ketoglutaric decarboxylase activity|pre-2-oxoglutarate decarboxylase activity|2-oxoglutarate carboxy-lyase activity|alpha-ketoglutarate decarboxylase activity KEGG_REACTION:R00272|EC:4.1.1.71|RHEA:10524|MetaCyc:RXN-7774 molecular_function owl:Class
GO:0018784 biolink:NamedThing (S)-2-haloacid dehalogenase activity Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide. got7fsn_ti 2-halocarboxylic acid dehalogenase II activity|DL-2-haloacid dehalogenase activity|(S)-2-haloacid halidohydrolase activity|2-haloacid dehalogenase activity|L-DEX activity|2-haloacid halidohydrolase activity|2-haloalkanoid acid halidohydrolase activity|halocarboxylic acid halidohydrolase activity|2-haloalkanoic acid dehalogenase activity|L-2-haloacid dehalogenase activity EC:3.8.1.2|UM-BBD_reactionID:r0090|RHEA:11192|MetaCyc:2-HALOACID-DEHALOGENASE-RXN molecular_function owl:Class
GO:0030519 biolink:NamedThing snoRNP binding Binding to a small nucleolar ribonucleoprotein particle. got7fsn_ti molecular_function owl:Class
GO:0030612 biolink:NamedThing arsenate reductase (thioredoxin) activity Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin. got7fsn_ti MetaCyc:RXN-10737 molecular_function owl:Class
GO:0048454 biolink:NamedThing sepal structural organization The process that contributes to the act of creating the structural organization of the sepal. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti sepal structural organisation GO:0048424 biological_process owl:Class
GO:1902023 biolink:NamedThing L-arginine transport The directed movement of a L-arginine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-arginine uptake|L-arginine import kmv 2013-03-27T16:09:11Z GO:0043091 biological_process owl:Class
GO:0015802 biolink:NamedThing basic amino acid transport The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0035871 biolink:NamedThing protein K11-linked deubiquitination A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein. got7fsn_ti protein K11-linked deubiquitylation|protein K11-linked deubiquitinylation bf 2011-05-26T11:44:13Z biological_process owl:Class
GO:0009304 biolink:NamedThing tRNA transcription The synthesis of transfer RNA (tRNA) from a DNA template. got7fsn_ti tRNA synthesis|tRNA biosynthesis|tRNA biosynthetic process biological_process owl:Class
GO:0008901 biolink:NamedThing ferredoxin hydrogenase activity Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2. got7fsn_ti [Fe] hydrogenase gamma|hydrogenase II|Ni-Fe-Se hydrogenase activity|hydrogenase I|hydrogenlyase activity|[Fe] hydrogenase activity|uptake hydrogenase activity|Ni-Fe hydrogenase activity|H(2) oxidizing hydrogenase activity|nickel-iron hydrogenase activity|H(2) producing hydrogenase activity|iron hydrogenase activity|H2 oxidizing hydrogenase|bidirectional hydrogenase activity|hydrogenase (ferredoxin) activity|hydrogenase activity|hydrogen-lyase activity|nickel hydrogenase activity|iron-only hydrogenase activity|nickel-iron-selenium hydrogenase activity|H2 producing hydrogenase|hydrogen:ferredoxin oxidoreductase activity Note that this function was formerly EC:1.12.1.1, EC:1.12.7.1, EC:1.98.1.1, EC:1.18.3.1 and EC:1.18.99.1. GO:0016951|GO:0016948|GO:0016950|GO:0016949 EC:1.12.7.2|RHEA:17445|MetaCyc:HYDROG-RXN|UM-BBD_enzymeID:e0418 molecular_function owl:Class
GO:0015330 biolink:NamedThing high-affinity glutamine transmembrane transporter activity Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity glutamine permease activity|high affinity glutamine transmembrane transporter activity molecular_function owl:Class
GO:0018406 biolink:NamedThing protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring. got7fsn_ti protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan|protein amino acid C-linked mannosylation GO:0032004 RESID:AA0217 biological_process owl:Class
GO:0060214 biolink:NamedThing endocardium formation Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers. got7fsn_ti biological_process owl:Class
GO:0031389 biolink:NamedThing Rad17 RFC-like complex A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p. got7fsn_ti Rad24p RFC-like complex|RFC (Rad17)|Rad17-RFC|Rad17-RLC cellular_component owl:Class
GO:0102574 biolink:NamedThing 3-oxo-myristoyl-ACP hydrolase activity Catalysis of the reaction: H2O + a 3-oxo-myristoyl-[acp] = 3-oxo-myristate + H+ + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-15280 molecular_function owl:Class
GO:0106219 biolink:NamedThing zinc ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of zinc. got7fsn_ti hjd 2019-08-15T16:45:43Z molecular_function owl:Class
GO:0044611 biolink:NamedThing nuclear pore inner ring A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex. got7fsn_ti Nup170 complex jl 2012-06-20T01:14:17Z cellular_component owl:Class
GO:0031395 biolink:NamedThing bursicon neuropeptide hormone complex A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits. got7fsn_ti cellular_component owl:Class
GO:0051561 biolink:NamedThing positive regulation of mitochondrial calcium ion concentration Any process that increases the concentration of calcium ions in mitochondria. got7fsn_ti mitochondrial calcium ion concentration elevation|elevation of calcium ion concentration in mitochondrion|elevation of mitochondrial calcium ion concentration|elevation of calcium ion concentration in mitochondria biological_process owl:Class
GO:0021816 biolink:NamedThing extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells. got7fsn_ti biological_process owl:Class
GO:0097602 biolink:NamedThing cullin family protein binding Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). got7fsn_ti cullin binding pr 2014-05-11T20:41:10Z molecular_function owl:Class
GO:0000250 biolink:NamedThing lanosterol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus. got7fsn_ti 2,3-epoxysqualene--lanosterol cyclase activity|squalene-2,3-oxide-lanosterol cyclase activity|squalene epoxidase-cyclase activity|oxidosqualene:lanosterol cyclase activity|2,3-epoxysqualene-lanosterol cyclase activity|2,3-oxidosqualene sterol cyclase activity|(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)|2,3-oxidosqualene-lanosterol cyclase activity|OSC|oxidosqualene--lanosterol cyclase activity|lanosterol 2,3-oxidosqualene cyclase activity|squalene 2,3-epoxide:lanosterol cyclase activity|2,3-epoxysqualene lanosterol cyclase activity|oxidosqualene-lanosterol cyclase activity RHEA:14621|MetaCyc:LANOSTEROL-SYNTHASE-RXN|EC:5.4.99.7|KEGG_REACTION:R03199|Reactome:R-HSA-191366 molecular_function owl:Class
GO:0070441 biolink:NamedThing G-protein beta/gamma-Btk complex A protein complex formed by the association of the Bruton tyrosine protein kinase Btk, which is implicated in mammalian X-linked immunodeficiencies, with the beta and gamma subunits of a heterotrimeric G protein. got7fsn_ti G protein complex (BTK, GNG1, GNG2)|G protein complex (Btk, Gng2, Gnb1) See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. cellular_component owl:Class
GO:0033707 biolink:NamedThing 3''-deamino-3''-oxonicotianamine reductase activity Catalysis of the reaction: 2'-deoxymugineic acid + NAD(P)+ = 3''-deamino-3''-oxonicotianamine + NAD(P)H + H+. got7fsn_ti 2'-deoxymugineic acid:NAD(P)+ 3''-oxidoreductase activity MetaCyc:1.1.1.285-RXN|EC:1.1.1.285 molecular_function owl:Class
GO:0000237 biolink:NamedThing leptotene The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Wikipedia:Leptotene|Wikipedia:Meiosis#Leptotene biological_process owl:Class
GO:0002201 biolink:NamedThing somatic diversification of DSCAM-based immune receptors The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects. got7fsn_ti Note that this type of immune receptor may not be limited to insects. biological_process owl:Class
GO:0062191 biolink:NamedThing galactoxylomannan biosynthetic process The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactoxylomannan. Galactoxylomannan is produced by a pathogenic fungus and causes paralysis in some animals. got7fsn_ti glucuronoxylomannogalactan biosynthetic process|galactoxylomannan formation|galactoxylomannan synthesis|GalXM biosynthetic process|galactoxylomannan anabolism|galactoxylomannan biosynthesis dph 2019-12-06T14:44:36Z biological_process owl:Class
GO:0008712 biolink:NamedThing ADP-glyceromanno-heptose 6-epimerase activity Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. got7fsn_ti ADPglyceromanno-heptose 6-epimerase activity|ADP-L-glycero-D-manno-heptose 6-epimerase activity KEGG_REACTION:R05176|MetaCyc:5.1.3.20-RXN|EC:5.1.3.20|RHEA:17577 molecular_function owl:Class
GO:0070684 biolink:NamedThing seminal clot liquefaction The reproductive process in which coagulated semen becomes liquid following ejaculation, allowing the progressive release of motile spermatozoa. got7fsn_ti semen liquefaction mah 2009-06-02T04:33:54Z biological_process owl:Class
GO:0097358 biolink:NamedThing D-leucyl-tRNA(Leu) deacylase activity Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu). got7fsn_ti pr 2012-07-04T09:18:12Z molecular_function owl:Class
GO:0102808 biolink:NamedThing pelargonidin 3-O-glucoside 2''-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + pelargonidin 3-O-beta-D-glucoside <=> H+ + pelargonidin 3-O-sophoroside + UDP. got7fsn_ti MetaCyc:RXN-8177 molecular_function owl:Class
GO:0045442 biolink:NamedThing deacetoxycephalosporin-C hydroxylase activity Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate. got7fsn_ti DACS|deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|deacetylcephalosporin C synthase activity|deacetoxycephalosporin C hydroxylase activity|3'-methylcephem hydroxylase activity|beta-lactam hydroxylase activity|DAOC hydroxylase activity EC:1.14.11.26|RHEA:16805|MetaCyc:1.14.11.26-RXN|KEGG_REACTION:R05229 molecular_function owl:Class
GO:0003187 biolink:NamedThing ventriculo bulbo valve morphogenesis The process in which the structure of the ventriculo bulbo valve is generated and organized. got7fsn_ti dph 2009-10-08T12:07:00Z biological_process owl:Class
GO:0052902 biolink:NamedThing spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity Catalysis of the reaction: H(2)O + O(2) + spermidine = 3-aminopropanal + H(2)O(2) + putrescine. got7fsn_ti polyamine oxidase activity|non-specific polyamine oxidase activity|N(1)-acetylpolyamine oxidase activity KEGG_REACTION:R09077|RHEA:25808|MetaCyc:RXN-10461|EC:1.5.3.17|MetaCyc:RXN-12089|EC:1.5.3.13 molecular_function owl:Class
GO:0140458 biolink:NamedThing pre-transcriptional gene silencing by RNA Any gene inactivation (silencing) process mediated by small RNA molecules that occur before the trancription begins. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19328 pg 2020-04-24T07:19:09Z biological_process owl:Class
GO:1990150 biolink:NamedThing VEGF-A complex A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase. got7fsn_ti vascular endothelial growth factor A complex bhm 2013-07-30T13:24:41Z cellular_component owl:Class
GO:0004340 biolink:NamedThing glucokinase activity Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate. got7fsn_ti glucokinase (phosphorylating)|ATP:D-glucose 6-phosphotransferase activity|glucose kinase activity EC:2.7.1.2|Reactome:R-HSA-5621918|RHEA:17825|Reactome:R-HSA-70420|Reactome:R-HSA-5621888|MetaCyc:GLUCOKIN-RXN molecular_function owl:Class
GO:0042117 biolink:NamedThing monocyte activation The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti biological_process owl:Class
GO:0047044 biolink:NamedThing androstan-3-alpha,17-beta-diol dehydrogenase activity Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. got7fsn_ti 20beta-HSD|3alpha(or 20beta)-hydroxysteroid dehydrogenase activity|dehydrogenase, 20beta-hydroxy steroid|(R)-20-hydroxysteroid dehydrogenase activity|3alpha,20beta-hydroxysteroid:NAD+-oxidoreductase activity|20beta-hydroxysteroid dehydrogenase activity|cortisone reductase activity|delta4-3-ketosteroid hydrogenase activity|NADH-20beta-hydroxysteroid dehydrogenase activity|3alpha(or 20beta)-hydroxysteroid:NAD+ oxidoreductase activity|3-alpha(or 20-beta)-hydroxysteroid dehydrogenase activity RHEA:22400|EC:1.1.1.53|MetaCyc:1.1.1.53-RXN molecular_function owl:Class
GO:0052755 biolink:NamedThing reduced coenzyme F420:quinone oxidoreductase activity Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone. got7fsn_ti F420H2-dependent quinone oxidoreductase activity|F420H2:2,3-dimethyl-1,4-naphthoquinone oxidoreductase activity|F420H2:quinone oxidoreductase activity ai 2011-09-22T04:08:13Z molecular_function owl:Class
GO:0052857 biolink:NamedThing NADPHX epimerase activity Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX. got7fsn_ti Reactome:R-HSA-6806966|RHEA:32227|EC:5.1.99.6 molecular_function owl:Class
GO:0048788 biolink:NamedThing cytoskeleton of presynaptic active zone The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites. got7fsn_ti synaptic ribbon|pre-synaptic ribbon|pre-synaptic cytoskeletal matrix assembled at active zones|T-bar ribbon|active zone cytomatrix|pre-synaptic dense body|CAZ|presynaptic cytoskeletal matrix assembled at active zones|T-bar|ribbon|presynaptic ribbon|presynaptic dense body|presynaptic cytoskeletal matrix|presynaptic cytomatrix assembled at active zones NIF_Subcellular:sao1470121605 cellular_component owl:Class
GO:0097276 biolink:NamedThing cellular creatinine homeostasis Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell. got7fsn_ti pr 2012-03-22T02:55:46Z biological_process owl:Class
GO:0070580 biolink:NamedThing base J metabolic process The chemical reactions and pathways involving base J (beta-D-glucosyl-hydroxymethyluracil), a hypermodified thymidine residue found in the genome of kinetoplastid parasites. This modified base is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. The base is synthesized in a two-step pathway. Initially, a thymidine residue in DNA is hydroxylated by a thymidine hydroxylase (TH) to form the intermediate hydroxymethyluracil, which is then glucosylated to form base J. got7fsn_ti base J metabolism|beta-D-glucosyl-HOMedU metabolic process|beta-D-glucosyl-hydroxymethyluracil metabolism mah 2009-04-22T02:37:23Z biological_process owl:Class
GO:0075511 biolink:NamedThing macropinosome lysis involved in viral entry into host cell Viral-induced lysis of the macropinosome involved in the uptake of a virus into a host cell. Occurs after internalization of the virus in a macropinosome, and results in the release of viral contents from the macropinosome into the host cell cytoplasm. got7fsn_ti jl 2011-07-27T11:38:07Z biological_process owl:Class
GO:0001648 biolink:NamedThing proteinase activated receptor activity A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. got7fsn_ti molecular_function owl:Class
GO:0005402 biolink:NamedThing carbohydrate:cation symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). got7fsn_ti cation:sugar symporter activity|cation/sugar symporter activity|sugar:cation symporter activity molecular_function owl:Class
GO:0000006 biolink:NamedThing high-affinity zinc transmembrane transporter activity Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity zinc uptake transmembrane transporter activity|high-affinity zinc uptake transmembrane transporter activity molecular_function owl:Class
GO:0046987 biolink:NamedThing N-acetyllactosamine beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-D-glucuronic acid to N-acetyllactosamine (galactosyl beta-1,4-N-acetylglucosamine). got7fsn_ti galactosyl beta-1,4 N-acetylglucosamine beta-1,3 glucuronosyltransferase activity molecular_function owl:Class
GO:0043237 biolink:NamedThing laminin-1 binding Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. got7fsn_ti laminin-111 binding molecular_function owl:Class
GO:0047614 biolink:NamedThing aconitate delta-isomerase activity Catalysis of the reaction: trans-aconitate = cis-aconitate. got7fsn_ti aconitate D-isomerase activity|aconitate delta2-delta3-isomerase activity|aconitate isomerase activity MetaCyc:ACONITATE-DELTA-ISOMERASE-RXN|KEGG_REACTION:R02244|RHEA:17265|EC:5.3.3.7 molecular_function owl:Class
GO:0014703 biolink:NamedThing oscillatory muscle contraction A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation. got7fsn_ti biological_process owl:Class
GO:0003010 biolink:NamedThing voluntary skeletal muscle contraction A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control. got7fsn_ti biological_process owl:Class
GO:0031843 biolink:NamedThing type 2 neuropeptide Y receptor binding Binding to a type 2 neuropeptide Y receptor. got7fsn_ti type 2 neuropeptide Y receptor ligand molecular_function owl:Class
GO:0043164 biolink:NamedThing Gram-negative-bacterium-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. got7fsn_ti 1-2nm peptidoglycan-based cell wall biogenesis|cell wall biosynthetic process|cell wall synthesis|cell wall anabolism|cell wall formation|cell wall assembly biological_process owl:Class
GO:0098873 biolink:NamedThing neuronal action potential back-propagation Propagation of an action potential in a neuron, from its site of initiation (typically the axon hillock) towards the soma. got7fsn_ti biological_process owl:Class
GO:0036406 biolink:NamedThing anchored component of periplasmic side of cell outer membrane The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only. got7fsn_ti anchored to internal side of cell outer membrane|anchored to periplasmic side of cell outer membrane bf 2013-08-15T11:45:39Z cellular_component owl:Class
GO:0051289 biolink:NamedThing protein homotetramerization The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits. got7fsn_ti protein homotetramer assembly|protein homotetramer biosynthetic process|protein homotetramer formation|protein homotetramer biosynthesis biological_process owl:Class
GO:0033440 biolink:NamedThing ACG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an ACG codon. got7fsn_ti threonine tRNA Note that in the standard genetic code, ACG codes for threonine. molecular_function owl:Class
GO:0000407 biolink:NamedThing phagophore assembly site Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction. got7fsn_ti PAS|perivacuolar space|pre-autophagosomal structure cellular_component owl:Class
GO:0098570 biolink:NamedThing stromal side of plastid inner membrane The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface. got7fsn_ti cellular_component owl:Class
GO:0043841 biolink:NamedThing (S)-lactate 2-kinase activity Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP. got7fsn_ti lactate 2-kinase activity MetaCyc:RXN-8076 molecular_function owl:Class
GO:0060252 biolink:NamedThing positive regulation of glial cell proliferation Any process that activates or increases the rate or extent of glial cell proliferation. got7fsn_ti biological_process owl:Class
GO:0033815 biolink:NamedThing biphenyl synthase activity Catalysis of the reaction: 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2. got7fsn_ti malonyl-CoA:benzoyl-CoA malonyltransferase activity|BIS MetaCyc:2.3.1.177-RXN|RHEA:22292|EC:2.3.1.177 molecular_function owl:Class
GO:0120209 biolink:NamedThing cone telodendria Cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina. got7fsn_ti krc 2019-05-21T00:01:34Z cellular_component owl:Class
GO:0035446 biolink:NamedThing cysteine-glucosaminylinositol ligase activity Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins. got7fsn_ti L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase|desacetylmycothiol synthase|MshC ligase bf 2010-04-14T11:33:06Z EC:6.3.1.13|RHEA:26176|MetaCyc:RXN1G-4 molecular_function owl:Class
GO:0001933 biolink:NamedThing negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. got7fsn_ti down regulation of protein amino acid phosphorylation|down-regulation of protein amino acid phosphorylation|negative regulation of protein amino acid phosphorylation|inhibition of protein amino acid phosphorylation|downregulation of protein amino acid phosphorylation biological_process owl:Class
GO:0031435 biolink:NamedThing mitogen-activated protein kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. got7fsn_ti MAPKKK binding molecular_function owl:Class
GO:0035887 biolink:NamedThing aortic smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta. got7fsn_ti bf 2011-06-08T11:34:26Z biological_process owl:Class
GO:0060591 biolink:NamedThing chondroblast differentiation The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes. got7fsn_ti chondrocyte progenitor cell differentiation dph 2009-05-11T07:47:36Z biological_process owl:Class
GO:0031625 biolink:NamedThing ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. got7fsn_ti ubiquitin ligase binding molecular_function owl:Class
GO:0047045 biolink:NamedThing testosterone 17-beta-dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. got7fsn_ti testosterone 17beta-dehydrogenase (NADP+)|17beta-hydroxysteroid:NADP+ 17-oxidoreductase activity|NADP-dependent testosterone-17beta-oxidoreductase activity|17-ketoreductase activity MetaCyc:1.1.1.64-RXN|RHEA:14981|EC:1.1.1.64|Wikipedia:Testosterone_17beta-dehydrogenase_(NADP+)|KEGG_REACTION:R01838 molecular_function owl:Class
GO:0042385 biolink:NamedThing myosin III complex A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain. got7fsn_ti cellular_component owl:Class
GO:0050733 biolink:NamedThing RS domain binding Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. got7fsn_ti molecular_function owl:Class
GO:0003111 biolink:NamedThing positive regulation of heart rate by circulating epinephrine The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction. got7fsn_ti positive regulation of heart rate by circulating adrenaline biological_process owl:Class
GO:0047208 biolink:NamedThing o-dihydroxycoumarin 7-O-glucosyltransferase activity Catalysis of the reaction: 7,8-dihydroxycoumarin + UDP-D-glucose = daphnin + H(+) + UDP. got7fsn_ti UDP-glucose:o-dihydroxycoumarin glucosyltransferase activity|UDPglucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-o-dihydroxycoumarin 7-O-glucosyltransferase activity|UDP-glucose:7,8-dihydroxycoumarin 7-O-beta-D-glucosyltransferase activity EC:2.4.1.104|MetaCyc:2.4.1.104-RXN|KEGG_REACTION:R03548|RHEA:14325 molecular_function owl:Class
GO:0051559 biolink:NamedThing phlobaphene biosynthetic process The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols. got7fsn_ti biological_process owl:Class
GO:1903524 biolink:NamedThing positive regulation of blood circulation Any process that activates or increases the frequency, rate or extent of blood circulation. got7fsn_ti up-regulation of hemolymph circulation|up regulation of hemolymph circulation|activation of blood circulation|up-regulation of blood circulation|upregulation of hemolymph circulation|positive regulation of hemolymph circulation|up regulation of blood circulation|activation of hemolymph circulation|upregulation of blood circulation mr 2014-10-06T18:39:13Z biological_process owl:Class
GO:0033078 biolink:NamedThing extrathymic T cell differentiation The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus. got7fsn_ti extrathymic T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0080103 biolink:NamedThing 4-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 4-methylthiopropyl-glucosinolate = 4-methylsulfinylpropyl-glucosinolate. got7fsn_ti dhl 2009-04-23T04:27:45Z molecular_function owl:Class
GO:0007077 biolink:NamedThing mitotic nuclear membrane disassembly The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis. got7fsn_ti local NEB|mitotic nuclear envelope catabolism|mitotic nuclear envelope breakdown|mitotic nuclear envelope degradation|nuclear envelope breakdown|mitotic nuclear envelope disassembly|NEB biological_process owl:Class
GO:0102827 biolink:NamedThing galactosylononitol-raffinose galactosyltransferase activity Catalysis of the reaction: raffinose + D-galactosylononitol = stachyose + 1D-4-O-methyl-myo-inositol. got7fsn_ti MetaCyc:RXN-8282 molecular_function owl:Class
GO:0022028 biolink:NamedThing tangential migration from the subventricular zone to the olfactory bulb The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration. got7fsn_ti rostral migratory stream migration biological_process owl:Class
GO:0001512 biolink:NamedThing dihydronicotinamide riboside quinone reductase activity Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone. got7fsn_ti QR2 activity|N-ribosyldihydronicotinamide dehydrogenase (quinone) activity|NQO(2) activity|NQO2|quinone reductase 2 activity|NRH:quinone oxidoreductase 2 activity|ribosyldihydronicotinamide dehydrogenase (quinone) activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.10.99.2. MetaCyc:1.10.99.2-RXN|EC:1.10.5.1|RHEA:12364|Reactome:R-HSA-8936519 molecular_function owl:Class
GO:0003883 biolink:NamedThing CTP synthase activity Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. got7fsn_ti UTP:ammonia ligase (ADP-forming)|cytidine 5'-triphosphate synthetase activity|UTP--ammonia ligase activity|CTP synthetase activity|uridine triphosphate aminase activity|cytidine triphosphate synthetase activity EC:6.3.4.2|Reactome:R-HSA-73647|RHEA:16597|Reactome:R-HSA-504054|MetaCyc:CTPSYN-RXN molecular_function owl:Class
GO:0016929 biolink:NamedThing SUMO-specific protease activity Catalysis of the hydrolysis of peptide or isopeptide bonds within SUMO, or between the SUMO and a larger protein to which it has been conjugated. got7fsn_ti ULP|SUSP This term should not be used for direct manual annotation because the supporting experiments should always distinguish whether the activity is part of maturation or SUMO removal. molecular_function owl:Class
GO:0060799 biolink:NamedThing transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt an endoderm fate. got7fsn_ti transforming growth factor beta receptor signalling pathway involved in endodermal cell fate specification dph 2009-08-06T11:24:01Z biological_process owl:Class
GO:0008695 biolink:NamedThing 3-phenylpropionate dioxygenase activity Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol. got7fsn_ti HcaA1A2CD|3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity|3-phenylpropanoate dioxygenase activity|Hca dioxygenase activity UM-BBD_enzymeID:e0307|EC:1.14.12.19|MetaCyc:HCAMULTI-RXN|RHEA:20357 molecular_function owl:Class
GO:0048047 biolink:NamedThing mating behavior, sex discrimination The behavior of individuals for the purpose of discriminating between the sexes, for the purpose of finding a suitable mating partner. got7fsn_ti mating behaviour, sex discrimination biological_process owl:Class
GO:0097725 biolink:NamedThing histone H3-K79 dimethylation The modification of histone H3 by addition of two methyl groups to lysine at position 79 of the histone. got7fsn_ti histone H3 K79 dimethylation|histone lysine H3 K79 dimethylation pr 2016-09-15T12:41:13Z biological_process owl:Class
GO:0034729 biolink:NamedThing histone H3-K79 methylation The modification of histone H3 by addition of a methyl group to lysine at position 79 of the histone. got7fsn_ti histone lysine H3 K79 methylation|histone H3K79me|histone H3 K79 methylation biological_process owl:Class
GO:0046659 biolink:NamedThing digestive hormone activity The action characteristic of a hormone that takes part in the digestion process. got7fsn_ti secretin molecular_function owl:Class
GO:0036133 biolink:NamedThing 11-hydroxythromboxane B2 dehydrogenase activity Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+. got7fsn_ti NAD dependent 11-hydroxythromboxane B2 dehydrogenase activity Note that the KEGG_REACTION:R05060 reaction does not stipulate the acceptor group, and is therefore slightly more general than the activity described by GO:0036133. bf 2012-03-05T11:05:09Z RHEA:52312|Reactome:R-HSA-2161732|KEGG_REACTION:R05060 molecular_function owl:Class
GO:0045342 biolink:NamedThing MHC class II biosynthetic process The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II. got7fsn_ti MHC class II anabolism|MHC class II biosynthesis|MHC class II formation|major histocompatibility complex class II biosynthesis|major histocompatibility complex class II biosynthetic process|MHC class II synthesis biological_process owl:Class
GO:0072529 biolink:NamedThing pyrimidine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof. got7fsn_ti pyrimidine-containing compound catabolism|pyrimidine-containing compound breakdown|pyrimidine and derivative catabolic process|pyrimidine-containing compound degradation mah 2011-01-04T03:27:51Z biological_process owl:Class
GO:0047739 biolink:NamedThing cephalosporin-C deacetylase activity Catalysis of the reaction: cephalosporin C + H(2)O = acetate + deacetylcephalosporin C + H(+). got7fsn_ti cephalosporin acetylesterase activity|cephalosporin C acetylesterase activity|cephalosporin C acetylase activity|cephalosporin-C acetylhydrolase activity|cephalosporin C deacetylase activity|cephalosporin C acetyl-esterase activity|cephalosporin C acetyl-hydrolase activity MetaCyc:CEPHALOSPORIN-C-DEACETYLASE-RXN|RHEA:22596|KEGG_REACTION:R03062|EC:3.1.1.41 molecular_function owl:Class
GO:0033529 biolink:NamedThing raffinose biosynthetic process The chemical reactions and pathways resulting in the formation of raffinose, the trisaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. got7fsn_ti raffinose synthesis|raffinose anabolism|raffinose biosynthesis|raffinose formation biological_process owl:Class
GO:0033978 biolink:NamedThing phosphonopyruvate hydrolase activity Catalysis of the reaction: 3-phosphonopyruvate + H(2)O = phosphate + pyruvate. got7fsn_ti PPH MetaCyc:3.11.1.3-RXN|EC:3.11.1.3|RHEA:16673|KEGG_REACTION:R08200 molecular_function owl:Class
GO:0004399 biolink:NamedThing histidinol dehydrogenase activity Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. got7fsn_ti RHEA:20641|MetaCyc:HISTALDEHYD-RXN|EC:1.1.1.23|MetaCyc:HISTOLDEHYD-RXN molecular_function owl:Class
GO:0033419 biolink:NamedThing CUA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CUA codon. got7fsn_ti CTA codon-amino acid adaptor activity|leucine tRNA Note that in the standard genetic code, CTA codes for leucine. molecular_function owl:Class
GO:0048849 biolink:NamedThing neurohypophysis formation The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation. got7fsn_ti posterior pituitary biosynthesis|posterior pituitary gland biosynthesis|neurophysis formation|posterior pituitary gland formation|neurophysis biosynthesis|posterior pituitary formation biological_process owl:Class
GO:0033775 biolink:NamedThing deoxysarpagine hydroxylase activity Catalysis of the reaction: 10-deoxysarpagine + H(+) + NADPH + O(2) = H(2)O + NADP(+) + sarpagine. got7fsn_ti DOSH|10-deoxysarpagine,NADPH:oxygen oxidoreductase (10-hydroxylating) activity KEGG_REACTION:R05828|MetaCyc:1.14.13.91-RXN|EC:1.14.14.136|RHEA:14237 molecular_function owl:Class
GO:0061698 biolink:NamedThing protein deglutarylation The removal of a glutaryl group (CO-CH2-CH2-CH2-CO) from a residue in a peptide or protein. got7fsn_ti dph 2015-05-07T11:02:31Z biological_process owl:Class
GO:0055036 biolink:NamedThing virion membrane The lipid bilayer surrounding a virion. got7fsn_ti cellular_component owl:Class
GO:0018150 biolink:NamedThing peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link. got7fsn_ti RESID:AA0250 biological_process owl:Class
GO:0102381 biolink:NamedThing stevioside glucosyltransferase activity (rebaudioside A forming) Catalysis of the reaction: stevioside + UDP-alpha-D-glucose = rebaudioside A + UDP + H+. got7fsn_ti MetaCyc:RXN-13517 molecular_function owl:Class
GO:0045520 biolink:NamedThing interleukin-24 receptor binding Binding to an interleukin-24 receptor. got7fsn_ti IL-24|interleukin-24 receptor ligand molecular_function owl:Class
GO:0033366 biolink:NamedThing protein localization to secretory granule A process in which a protein is transported to, or maintained in, a location within a secretory granule. got7fsn_ti protein localization in secretory granule|protein localisation in secretory granule biological_process owl:Class
GO:0018809 biolink:NamedThing E-phenylitaconyl-CoA hydratase activity Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA. got7fsn_ti UM-BBD_reactionID:r0331 molecular_function owl:Class
GO:0030037 biolink:NamedThing actin filament reorganization involved in cell cycle The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs. got7fsn_ti actin filament reorganization during cell cycle|actin filament reorganisation involved in cell cycle biological_process owl:Class
GO:0097681 biolink:NamedThing double-strand break repair via alternative nonhomologous end joining An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment. got7fsn_ti double-strand break repair via microhomology-mediated end joining|A-NHEJ|alt-NHEJ|MMEJ pr 2014-12-17T15:17:45Z biological_process owl:Class
GO:0102081 biolink:NamedThing homotaurine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: homotaurine + 2-oxoglutarate(2-) <=> 3-sulfopropanal + L-glutamate(1-). got7fsn_ti MetaCyc:RXN-10822 molecular_function owl:Class
GO:0102915 biolink:NamedThing piperitol synthase activity Catalysis of the reaction: H+ + (+)-pinoresinol + NADPH + O2 <=> (+)-piperitol + NADP + 2 H2O. got7fsn_ti MetaCyc:RXN-8695 molecular_function owl:Class
GO:0047536 biolink:NamedThing 2-aminoadipate transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate. got7fsn_ti glutamic-ketoadipic transaminase activity|L-2-aminoadipate:2-oxoglutarate aminotransferase activity|alpha-aminoadipate aminotransferase activity|2-aminoadipate aminotransferase activity|glutamate-alpha-ketoadipate transaminase activity|2-aminoadipic aminotransferase activity Reactome:R-HSA-508561|KEGG_REACTION:R01939|EC:2.6.1.39|Reactome:R-HSA-70952|MetaCyc:2-AMINOADIPATE-AMINOTRANSFERASE-RXN|RHEA:12601 molecular_function owl:Class
GO:0090736 biolink:NamedThing MATH domain binding Binding to a meprin and TRAF homology (MATH) domain. got7fsn_ti tb 2017-02-06T17:08:28Z molecular_function owl:Class
GO:0047167 biolink:NamedThing 1-alkyl-2-acetylglycerol O-acyltransferase activity Catalysis of the reaction: 1-O-alkyl-2-acetyl-sn-glycerol + acyl-CoA = 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol + CoA. got7fsn_ti 1-hexadecyl-2-acetylglycerol acyltransferase activity|acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase activity MetaCyc:2.3.1.125-RXN|RHEA:21996|EC:2.3.1.125 molecular_function owl:Class
GO:0140569 biolink:NamedThing extraction of mislocalized protein from ER membrane The removal of a mislocalized protein from the endoplasmic reticulum (ER) membrane. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20237 pg 2020-12-15T07:36:46Z biological_process owl:Class
GO:0106344 biolink:NamedThing 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] = (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase]. got7fsn_ti 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP https://github.com/geneontology/go-ontology/issues/20274 hjd 2020-12-04T14:48:37Z RHEA:65756 molecular_function owl:Class
GO:0004123 biolink:NamedThing cystathionine gamma-lyase activity Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+. got7fsn_ti gamma-cystathionase activity|L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)|homoserine deaminase activity|L-cystathionine cysteine-lyase (deaminating)|homoserine deaminase-cystathionase activity|homoserine dehydratase activity GO:0016225 EC:4.4.1.1|MetaCyc:CYSTAGLY-RXN|Reactome:R-HSA-1614583|RHEA:14005|KEGG_REACTION:R01001 molecular_function owl:Class
GO:0042791 biolink:NamedThing 5S class rRNA transcription by RNA polymerase III The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter. got7fsn_ti 5S rRNA transcription|5S class rRNA transcription from RNA polymerase III type 1 promoter biological_process owl:Class
GO:0031291 biolink:NamedThing Ran protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state. got7fsn_ti biological_process owl:Class
GO:0044824 biolink:NamedThing retroviral 3' processing activity The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls. got7fsn_ti 3'-processing activity|3' processing reaction This reaction may serve to remove heterogeneous extra bases from the viral DNA end, and to stabilize the integrase-DNA complex. The chemistry of cleavage is a simple hydrolysis by single-step transesterification. jl 2014-02-04T14:51:24Z molecular_function owl:Class
GO:0035211 biolink:NamedThing spermathecum morphogenesis The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk. got7fsn_ti See also the fly_anatomy.ontology term 'spermathecum ; FBbt:00004921'. biological_process owl:Class
GO:0044353 biolink:NamedThing micropinosome A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis. got7fsn_ti jl 2011-08-11T10:51:27Z cellular_component owl:Class
GO:0061677 biolink:NamedThing 2-dehydro-3-deoxy-D-gluconate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate <=> pyruvate + D-glyceraldehyde. got7fsn_ti KDG aldolase activity|2-keto-3-deoxygluconate aldolase activity dph 2015-01-15T13:46:25Z GO:0043725 EC:4.1.2.51|RHEA:35583|MetaCyc:DHDOGALDOL-RXN|MetaCyc:4.1.2.51-RXN molecular_function owl:Class
GO:0031703 biolink:NamedThing type 2 angiotensin receptor binding Binding to a type 2 angiotensin receptor. got7fsn_ti type 2 angiotensin receptor ligand|AT2 receptor binding molecular_function owl:Class
GO:0052719 biolink:NamedThing apurinic/apyrimidinic endoribonuclease activity Catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends. got7fsn_ti apurinic endoribonuclease activity|apyrimidinic endoribonuclease activity|abasic endoribonuclease activity|AP endoribonuclease activity molecular_function owl:Class
GO:0008535 biolink:NamedThing respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. got7fsn_ti cytochrome c oxidase complex assembly|cytochrome c oxidase biogenesis biological_process owl:Class
GO:1900564 biolink:NamedThing chanoclavine-I metabolic process The chemical reactions and pathways involving chanoclavine-I. got7fsn_ti chanoclavine-I metabolism di 2012-05-15T06:30:25Z biological_process owl:Class
GO:0032542 biolink:NamedThing sulfiredoxin activity Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R. got7fsn_ti Srx1|peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]|sulphiredoxin activity|peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity RHEA:17545|EC:1.8.98.2|MetaCyc:1.8.98.2-RXN molecular_function owl:Class
GO:0050469 biolink:NamedThing sabinene-hydrate synthase activity Catalysis of the reaction: geranyl diphosphate + H(2)O = diphosphate + sabinene hydrate. got7fsn_ti geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)|sabinene hydrate cyclase activity MetaCyc:4.2.3.11-RXN|RHEA:19565|KEGG_REACTION:R02006|EC:4.2.3.11 molecular_function owl:Class
GO:0071979 biolink:NamedThing cytoskeleton-mediated cell swimming Cell motility in which contractile cytoskeletal elements alter cell shape, resulting in the smooth movement of a cell through a liquid medium. got7fsn_ti cytoskeleton-mediated swimming motility mah 2010-10-21T03:02:36Z biological_process owl:Class
GO:0031642 biolink:NamedThing negative regulation of myelination Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons. got7fsn_ti inhibition of myelination|down regulation of myelination|downregulation of myelination|down-regulation of myelination biological_process owl:Class
GO:0034536 biolink:NamedThing 2-hydroxy-8-methylchromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxy-8-methylchromene-2-carboxylate = 2-hydroxy-3-methylbenzalpyruvate. got7fsn_ti UM-BBD_reactionID:r0782|EC:5.3.99.- molecular_function owl:Class
GO:0031473 biolink:NamedThing myosin III binding Binding to a class III myosin; myosin III is monomeric and has an N terminal kinase domain. got7fsn_ti molecular_function owl:Class
GO:0032486 biolink:NamedThing Rap protein signal transduction A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state. got7fsn_ti biological_process owl:Class
GO:0110014 biolink:NamedThing negative regulation of aggregation involved in sorocarp development Any process that decreases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug. got7fsn_ti kmv 2017-05-10T12:53:12Z biological_process owl:Class
GO:0019323 biolink:NamedThing pentose catabolic process The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule. got7fsn_ti pentose degradation|pentose catabolism|pentose breakdown biological_process owl:Class
GO:0010489 biolink:NamedThing UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose. got7fsn_ti molecular_function owl:Class
GO:0031545 biolink:NamedThing peptidyl-proline 4-dioxygenase activity Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2. got7fsn_ti prolyl 4-hydroxylase|HIF-type prolyl 4-hydroxylase Reactome:R-HSA-1234173|Reactome:R-HSA-1234181|Reactome:R-HSA-1234179|Reactome:R-HSA-1234165|Reactome:R-HSA-1234166|Reactome:R-HSA-1234177 molecular_function owl:Class
GO:0010239 biolink:NamedThing chloroplast mRNA processing Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs. got7fsn_ti biological_process owl:Class
GO:0047843 biolink:NamedThing dehydrogluconate dehydrogenase activity Catalysis of the reaction: 2-dehydro-D-gluconate + A = 2,5-didehydro-D-gluconate + AH(2). got7fsn_ti alpha-ketogluconate dehydrogenase activity|ketogluconate dehydrogenase activity|2-dehydro-D-gluconate:acceptor 2-oxidoreductase activity|2-oxogluconate dehydrogenase activity|2-keto-D-gluconate dehydrogenase activity KEGG_REACTION:R07153|MetaCyc:DEHYDROGLUCONATE-DEHYDROGENASE-RXN|RHEA:12368|EC:1.1.99.4 molecular_function owl:Class
GO:1990311 biolink:NamedThing type-I cohesin domain binding Binding to a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain. got7fsn_ti tt 2014-03-07T04:47:31Z molecular_function owl:Class
GO:0047551 biolink:NamedThing 2-oxoaldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo acid + NADH + H+. got7fsn_ti 2-ketoaldehyde dehydrogenase|2-oxoaldehyde dehydrogenase (NAD+)|NAD-dependent alpha-ketoaldehyde dehydrogenase activity|NAD-linked alpha-ketoaldehyde dehydrogenase activity|alpha-ketoaldehyde dehydrogenase activity|2-oxoaldehyde:NAD+ 2-oxidoreductase activity|methylglyoxal dehydrogenase activity Wikipedia:2-oxoaldehyde_dehydrogenase_(NAD+)|EC:1.2.1.23|MetaCyc:2-OXOALDEHYDE-DEHYDROGENASE-NAD+-RXN|RHEA:22276 molecular_function owl:Class
GO:0097535 biolink:NamedThing lymphoid lineage cell migration into thymus The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process. got7fsn_ti lymphoid lineage restricted progenitor cell migration into thymus pr 2013-11-28T10:48:58Z biological_process owl:Class
GO:2001232 biolink:NamedThing positive regulation of protein localization to prospore membrane Any process that activates or increases the frequency, rate or extent of protein localization to prospore membrane. got7fsn_ti positive regulation of protein localisation to prospore membrane|positive regulation of protein targeting to forespore membrane|positive regulation of protein targeting to FSM|positive regulation of protein targeting to prospore membrane|positive regulation of protein targeting to ascospore-type prospore membrane|positive regulation of protein-prospore membrane targeting mah 2011-11-21T04:13:36Z biological_process owl:Class
GO:1903078 biolink:NamedThing positive regulation of protein localization to plasma membrane Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane. got7fsn_ti up-regulation of protein targeting to plasma membrane|activation of protein localisation in plasma membrane|up-regulation of protein localization to plasma membrane|activation of protein localization to plasma membrane|up regulation of protein targeting to plasma membrane|positive regulation of establishment of protein localisation in plasma membrane|activation of protein-plasma membrane targeting|upregulation of protein localization to plasma membrane|positive regulation of protein localisation in plasma membrane|positive regulation of protein targeting to plasma membrane|up-regulation of protein localisation in plasma membrane|up-regulation of protein-plasma membrane targeting|up regulation of protein localization to plasma membrane|upregulation of protein localization in plasma membrane|up regulation of protein localization in plasma membrane|upregulation of protein localisation in plasma membrane|up regulation of protein localisation in plasma membrane|up-regulation of protein localization in plasma membrane|positive regulation of protein localization in plasma membrane|positive regulation of protein-plasma membrane targeting|activation of protein localization in plasma membrane|up regulation of protein-plasma membrane targeting|activation of protein targeting to plasma membrane|upregulation of protein targeting to plasma membrane|positive regulation of establishment of protein localization to plasma membrane|upregulation of protein-plasma membrane targeting tb 2009-07-10T10:34:17Z GO:0090004|GO:1905965 biological_process owl:Class
GO:0035939 biolink:NamedThing microsatellite binding Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem. got7fsn_ti variable number tandem repeat binding|microsatellite DNA binding|VNTR binding bf 2011-07-20T01:26:26Z molecular_function owl:Class
GO:0033810 biolink:NamedThing anthocyanin 5-O-glucoside 6'''-O-malonyltransferase activity Catalysis of the reaction: malonyl-CoA + pelargonidin 3-O-(6-caffeoyl-beta-D-glucoside) 5-O-beta-D-glucoside = CoA + 4'''-demalonylsalvianin. got7fsn_ti Ss5MaT1|malonyl-CoA:pelargonidin-3-O-(6-caffeoyl-beta-D-glucoside)-5-O-beta-D-glucoside 6'''-O-malonyltransferase activity RHEA:21988|MetaCyc:2.3.1.172-RXN|EC:2.3.1.172 molecular_function owl:Class
GO:0036203 biolink:NamedThing taxoid 14-beta-hydroxylase activity Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O. got7fsn_ti bf 2012-04-20T02:40:54Z KEGG_REACTION:R09867|RHEA:31971|EC:1.14.13.146 molecular_function owl:Class
GO:0010994 biolink:NamedThing free ubiquitin chain polymerization The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein. got7fsn_ti tb 2009-06-03T11:41:03Z biological_process owl:Class
GO:0103058 biolink:NamedThing kaempferol 3-glucoside 7-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol 3-O-glucoside + UDP-L-rhamnose <=> kaempferol-3-glucoside-7-rhamnoside + UDP. got7fsn_ti MetaCyc:RXN1F-443 molecular_function owl:Class
GO:1990535 biolink:NamedThing neuron projection maintenance The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. got7fsn_ti axon maintenance|neuron process maintenance|neurite maintenance|neuron protrusion maintenance|axon homeostasis|neuronal cell projection maintenance kmv 2014-11-13T22:24:05Z biological_process owl:Class
GO:0052678 biolink:NamedThing levopimaradiene synthase activity Catalysis of the reaction: (+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate. got7fsn_ti ent-copalyl-diphosphate diphosphate-lyase [ent-abieta-8(14),12-diene-forming] activity MetaCyc:4.2.3.32-RXN|RHEA:25548|EC:4.2.3.32|KEGG_REACTION:R06302 molecular_function owl:Class
GO:0015092 biolink:NamedThing high-affinity ferric iron transmembrane transporter activity Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity ferric uptake transmembrane transporter activity https://github.com/geneontology/go-ontology/issues/14372 molecular_function owl:Class
GO:0021861 biolink:NamedThing forebrain radial glial cell differentiation The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti radial glial cell differentiation in forebrain biological_process owl:Class
GO:0097316 biolink:NamedThing cellular response to N-acetyl-D-glucosamine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus. got7fsn_ti pr 2012-05-30T04:01:02Z biological_process owl:Class
GO:0018981 biolink:NamedThing triethanolamine metabolic process The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent. got7fsn_ti triethanolamine metabolism UM-BBD_pathwayID:tea biological_process owl:Class
GO:0097698 biolink:NamedThing telomere maintenance via base-excision repair A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature. got7fsn_ti pr 2016-01-07T11:15:39Z biological_process owl:Class
GO:0031168 biolink:NamedThing ferrichrome metabolic process The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. got7fsn_ti ferrichrome metabolism biological_process owl:Class
GO:0031932 biolink:NamedThing TORC2 complex A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p. got7fsn_ti mTORC2|TORC 2 complex|TORC2|rapamycin and nutrient-insensitive TOR complex|TOR complex 2 Wikipedia:MTORC1 cellular_component owl:Class
GO:0008255 biolink:NamedThing ecdysis-triggering hormone activity The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system. got7fsn_ti molecular_function owl:Class
GO:0103063 biolink:NamedThing trans-keto-C61-meroacyl-AMP ligase activity Catalysis of the reaction: ATP(4-) + H2O + a trans-keto-C61-meroacyl-[acp] <=> diphosphoric acid + a trans-keto-meroacyl-adenylate + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN1G-4143 molecular_function owl:Class
GO:0042443 biolink:NamedThing phenylethylamine metabolic process The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. got7fsn_ti phenylethylamine metabolism biological_process owl:Class
GO:0075000 biolink:NamedThing response to host osmotic environment Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the osmotic conditions in or around its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response of symbiont to host osmotic environment biological_process owl:Class
GO:0150092 biolink:NamedThing regulation of synaptic scaling A process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell. got7fsn_ti regulation of homeostatic synaptic scaling|homeostatic synaptic scaling bc 2018-08-09T16:27:28Z biological_process owl:Class
GO:0042292 biolink:NamedThing URM1 activating enzyme activity Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti molecular_function owl:Class
GO:0004474 biolink:NamedThing malate synthase activity Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+). got7fsn_ti glyoxylate transacetase activity|acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)|malic synthetase activity|malate condensing enzyme activity|glyoxylic transacetase activity|malate synthetase activity|glyoxylate transacetylase activity|malic-condensing enzyme activity|L-malate glyoxylate-lyase (CoA-acetylating) activity Note that this function was formerly EC:4.1.3.2. MetaCyc:MALSYN-RXN|RHEA:18181|EC:2.3.3.9|KEGG_REACTION:R00472 molecular_function owl:Class
GO:2001309 biolink:NamedThing gliotoxin catabolic process The chemical reactions and pathways resulting in the breakdown of the epipolythiodioxopiperazine gliotoxin, a poisonous substance produced by some species of fungi. got7fsn_ti gliotoxin catabolism|gliotoxin breakdown|gliotoxin degradation pr 2012-03-15T03:42:14Z biological_process owl:Class
GO:0032296 biolink:NamedThing double-stranded RNA-specific ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules. got7fsn_ti dsRNA-specific ribonuclease activity|double-stranded RNA-specific RNase activity|dsRNA-specific RNase activity molecular_function owl:Class
GO:0039723 biolink:NamedThing suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1. got7fsn_ti inhibition of host TBK1 by virus|suppression by virus of host TBK1 activity https://github.com/geneontology/go-ontology/issues/21970 bf 2014-01-06T12:04:44Z biological_process owl:Class
GO:0102936 biolink:NamedThing gypsogenate-UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenate = gypsogenate-28-beta-D-glucoside + UDP. got7fsn_ti MetaCyc:RXN-9013 molecular_function owl:Class
GO:0002326 biolink:NamedThing B cell lineage commitment The process in which a lymphoid progenitor cell becomes committed to become any type of B cell. got7fsn_ti B lymphocyte lineage commitment|B-cell lineage commitment|B-lymphocyte lineage commitment biological_process owl:Class
GO:0004076 biolink:NamedThing biotin synthase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+). got7fsn_ti dethiobiotin:sulfur sulfurtransferase activity|biotin synthetase activity RHEA:22060|EC:2.8.1.6|MetaCyc:2.8.1.6-RXN|KEGG_REACTION:R01078 molecular_function owl:Class
GO:0047305 biolink:NamedThing (R)-3-amino-2-methylpropionate-pyruvate transaminase activity Catalysis of the reaction: (2R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine. got7fsn_ti beta-aminoisobutyrate--pyruvate transaminase activity|D-3-aminoisobutyrate--pyruvate transaminase activity|(R)-3-amino-2-methylpropanoate transaminase activity|D-beta-aminoisobutyrate:pyruvate aminotransferase activity|(R)-3-amino-2-methylpropionate-pyruvate aminotransferase activity|beta-aminoisobutyrate-pyruvate aminotransferase activity|D-AIBAT activity|(R)-3-amino-2-methylpropanoate aminotransferase activity|D-3-aminoisobutyrate-pyruvate transaminase activity|(R)-3-amino-2-methylpropionate--pyruvate aminotransferase activity|(R)-3-amino-2-methylpropanoate:pyruvate aminotransferase activity|D-3-aminoisobutyrate--pyruvate aminotransferase activity|(R)-3-amino-2-methylpropionate transaminase activity Note that this function was EC:2.6.1.61. GO:0047314 Reactome:R-HSA-909780|KEGG_REACTION:R02050|EC:2.6.1.40|MetaCyc:2.6.1.40-RXN|RHEA:18393 molecular_function owl:Class
GO:0046480 biolink:NamedThing galactolipid galactosyltransferase activity Catalysis of the reaction: 2 mono-beta-D-galactosyldiacylglycerol = alpha-D-galactosyl-beta-D-galactosyldiacylglycerol + 1,2-diacylglycerol. got7fsn_ti GGGT activity|3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol:mono-3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol beta-D-galactosyltransferase activity|galactolipid-galactolipid galactosyltransferase activity|galactolipid:galactolipid galactosyltransferase activity|digalactosyldiacylglycerol synthase activity|DGDG synthase activity|interlipid galactosyltransferase activity MetaCyc:RXN-1226|EC:2.4.1.184|RHEA:15921 molecular_function owl:Class
GO:0033420 biolink:NamedThing CUG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CUG codon. got7fsn_ti CTG codon-amino acid adaptor activity|leucine tRNA Note that in the standard genetic code, CTG codes for leucine. molecular_function owl:Class
GO:0060183 biolink:NamedThing apelin receptor signaling pathway The series of molecular signals generated as a consequence of an apelin receptor binding to one of its physiological ligands. got7fsn_ti apelin receptor signalling pathway biological_process owl:Class
GO:0070200 biolink:NamedThing establishment of protein localization to telomere The directed movement of a protein to a specific location in the telomeric region of a chromosome. got7fsn_ti establishment of protein localization to chromosome, telomeric region|establishment of protein localisation to telomere biological_process owl:Class
GO:0046737 biolink:NamedThing induction of cell-mediated immune response in host by virus The intentional, virally-encoded stimulation of a cell-mediated host defense response to viral infection. got7fsn_ti active induction of cell-mediated immune response in host by virus|active viral induction of cell-mediated immune response in host biological_process owl:Class
GO:0050500 biolink:NamedThing 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate. got7fsn_ti beta-D-galactopyranosyl-(1->3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity|beta-1,3-galactosyl-N-acetylhexosamine phosphorylase activity|beta-D-galactopyranosyl-(1,3)-N-acetyl-D-hexosamine:phosphate galactosyltransferase activity RHEA:20285|EC:2.4.1.211|MetaCyc:2.4.1.211-RXN molecular_function owl:Class
GO:0061768 biolink:NamedThing magnesium:sodium antiporter activity Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in). got7fsn_ti dph 2016-05-04T14:45:45Z molecular_function owl:Class
GO:0062206 biolink:NamedThing manoyl oxide synthase activity Catalysis of the reaction: 8-hydroxycopalyl diphosphate = (13R)-manoyl oxide + diphosphate. got7fsn_ti dph 2020-01-03T14:48:52Z EC:4.2.3.190|RHEA:54516 molecular_function owl:Class
GO:0034277 biolink:NamedThing ent-cassa-12,15-diene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate. got7fsn_ti ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming) activity MetaCyc:RXN-4881|RHEA:25532|EC:4.2.3.28|KEGG_REACTION:R09119 molecular_function owl:Class
GO:0017086 biolink:NamedThing 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate. got7fsn_ti branched-chain alpha-ketoacid dehydrogenase complex|BCADH GO:0031212 cellular_component owl:Class
GO:0102301 biolink:NamedThing gamma-linolenate elongase activity Catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide. got7fsn_ti MetaCyc:RXN-12777 molecular_function owl:Class
GO:0052587 biolink:NamedThing diacetyl reductase ((R)-acetoin forming) activity Catalysis of the reaction: (R)-acetoin + NAD(+) = diacetyl + H(+) + NADH. got7fsn_ti (R)-acetoin dehydrogenase activity KEGG_REACTION:R02855|MetaCyc:RXN-11036|RHEA:22900|EC:1.1.1.303 molecular_function owl:Class
GO:0102494 biolink:NamedThing GA20 2,3-desaturase activity Catalysis of the reaction: gibberellin A20 + O2 + a reduced electron acceptor <=> gibberellin A5 + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-14317 molecular_function owl:Class
GO:0033876 biolink:NamedThing glycochenodeoxycholate sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H(+). got7fsn_ti BAST|bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase activity|bile acid:PAPS:sulfotransferase activity|3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase activity EC:2.8.2.34|KEGG_REACTION:R07289|MetaCyc:2.8.2.34-RXN|RHEA:17689 molecular_function owl:Class
GO:0004768 biolink:NamedThing stearoyl-CoA 9-desaturase activity Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O. got7fsn_ti fatty acid desaturase|stearoyl-CoA desaturase activity|delta(9)-desaturase activity|delta9-desaturase|acyl-CoA desaturase Note that this function was formerly EC:1.14.99.5. GO:0043735|GO:0016214 EC:1.14.19.1|Reactome:R-HSA-5690565|RHEA:19721|MetaCyc:1.14.19.1-RXN|Reactome:R-HSA-8847579 molecular_function owl:Class
GO:0007546 biolink:NamedThing somatic processes downstream of sex determination signal The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways. got7fsn_ti biological_process owl:Class
GO:0070176 biolink:NamedThing DRM complex A transcriptional repressor complex that contains the lin-9, lin-35, lin-37, lin-52, lin-53, lin-5is involved in 4-, dpl-1 and efl-1 proteins, and is involved in cell fate specification. got7fsn_ti DP/Rb/MuvB cellular_component owl:Class
GO:0102706 biolink:NamedThing butein:oxygen oxidoreductase activity Catalysis of the reaction: butein 4'-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O + H+. got7fsn_ti RHEA:34203|EC:1.21.3.6|MetaCyc:RXN-6242 molecular_function owl:Class
GO:0031013 biolink:NamedThing troponin I binding Binding to troponin I, the inhibitory subunit of the troponin complex. got7fsn_ti molecular_function owl:Class
GO:0008968 biolink:NamedThing D-sedoheptulose 7-phosphate isomerase activity Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate. got7fsn_ti phosphoheptose isomerase activity RHEA:27489|MetaCyc:RXN0-4301 molecular_function owl:Class
GO:0016251 biolink:NamedThing RNA polymerase II general transcription initiation factor activity A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. got7fsn_ti general RNA polymerase II transcription factor activity|sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly|transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly|GTF2 activity|basal RNA polymerase II transcription factor activity https://github.com/geneontology/go-ontology/issues/20253 General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur. GO:0000983|GO:0001075|GO:0003703 molecular_function owl:Class
GO:0102909 biolink:NamedThing alpha-ketoglutarate reductase activity (NADH-dependent) Catalysis of the reaction: NAD + 2-hydroxyglutarate = H+ + 2-oxoglutarate + NADH. got7fsn_ti MetaCyc:RXN-8645 molecular_function owl:Class
GO:0071696 biolink:NamedThing ectodermal placode development The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm. got7fsn_ti mah 2010-03-02T11:48:01Z biological_process owl:Class
GO:0035380 biolink:NamedThing very long-chain-3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22. got7fsn_ti very-long-chain-3-hydroxyacyl-CoA dehydrogenase activity bf 2010-03-18T11:23:05Z molecular_function owl:Class
GO:0033424 biolink:NamedThing CCG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CCG codon. got7fsn_ti proline tRNA Note that in the standard genetic code, CCG codes for proline. molecular_function owl:Class
GO:0042271 biolink:NamedThing susceptibility to natural killer cell mediated cytotoxicity The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity. got7fsn_ti susceptibility to natural killer cell mediated cell killing|susceptibility to natural killer cell mediated cytolysis|susceptibility to natural killer cell mediated cell death|susceptibility to NK cell mediated cell killing|susceptibility to NK cell mediated cytotoxicity|susceptibility to NK cell mediated cell death|susceptibility to NK cell mediated cytolysis Note that this term is intended for cell-surface molecules on a target cell which interact with activating receptors on a natural killer cell to promote natural killer cell mediated cytotoxicity. biological_process owl:Class
GO:0045954 biolink:NamedThing positive regulation of natural killer cell mediated cytotoxicity Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity. got7fsn_ti positive regulation of NK cell mediated cytolysis|up-regulation of natural killer cell mediated cytotoxicity|activation of natural killer cell mediated cytotoxicity|upregulation of natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytolysis|up regulation of natural killer cell mediated cytotoxicity|stimulation of natural killer cell mediated cytotoxicity|positive regulation of NK cell mediated cell killing|positive regulation of natural killer cell mediated cell death|positive regulation of natural killer cell mediated cell killing|positive regulation of NK cell mediated cell death|positive regulation of NK cell mediated cytotoxicity biological_process owl:Class
GO:0006435 biolink:NamedThing threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA. got7fsn_ti biological_process owl:Class
GO:0033449 biolink:NamedThing GUU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GUU codon. got7fsn_ti GTT codon-amino acid adaptor activity|valine tRNA Note that in the standard genetic code, GTT codes for valine. molecular_function owl:Class
GO:1990030 biolink:NamedThing pericellular basket Ramification of basket cell axon surrounding cell bodies, forming the characteristic pericellular baskets from which the cell class derives its name. got7fsn_ti peri cellular basket|peri-cellular basket pr 2013-02-07T12:53:54Z NIF_Subcellular:sao413722576 cellular_component owl:Class
GO:0044843 biolink:NamedThing cell cycle G1/S phase transition The cell cycle process by which a cell in G1 phase commits to S phase. got7fsn_ti jl 2014-03-25T16:33:47Z biological_process owl:Class
GO:0086091 biolink:NamedThing regulation of heart rate by cardiac conduction A cardiac conduction process that modulates the frequency or rate of heart contraction. got7fsn_ti dph 2011-11-29T01:04:19Z biological_process owl:Class
GO:0097695 biolink:NamedThing establishment of protein-containing complex localization to telomere The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome. got7fsn_ti establishment of macromolecular complex localization to telomere|establishment of macromolecular complex localisation to telomere pr 2015-12-22T09:38:13Z biological_process owl:Class
GO:0004773 biolink:NamedThing steryl-sulfatase activity Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate. got7fsn_ti arylsulfatase C activity|phenolic steroid sulfatase activity|steroid sulfate sulfohydrolase activity|dehydroepiandrosterone sulfate sulfatase activity|3-beta-hydroxysteroid sulfate sulfatase activity|steryl-sulfate sulfohydrolase activity|sterol sulfatase activity|steroid 3-sulfatase activity|pregnenolone sulfatase activity|steroid sulfatase activity|dehydroepiandrosterone sulfatase activity|steryl-sulphatase activity EC:3.1.6.2|Reactome:R-HSA-1606839|MetaCyc:STERYL-SULFATASE-RXN|RHEA:19873 molecular_function owl:Class
GO:0070846 biolink:NamedThing Hsp90 deacetylation The modification of an Hsp90 protein by removal of acetyl groups. got7fsn_ti mah 2009-07-31T12:58:47Z biological_process owl:Class
GO:0010418 biolink:NamedThing rhamnogalacturonan II backbone metabolic process The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues. got7fsn_ti rhamnogalacturonan II backbone metabolism biological_process owl:Class
GO:0010396 biolink:NamedThing rhamnogalacturonan II metabolic process The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues. got7fsn_ti rhamnogalacturonan II metabolism biological_process owl:Class
GO:0047697 biolink:NamedThing beta-alanopine dehydrogenase activity Catalysis of the reaction: (R)-beta-alanopine + H(2)O + NAD(+) = beta-alanine + H(+) + NADH + pyruvate. got7fsn_ti N-(D-1-carboxyethyl)-beta-alanine:NAD+ oxidoreductase (beta-alanine-forming)|b-alanopine dehydrogenase activity RHEA:21684|EC:1.5.1.26|KEGG_REACTION:R00906|MetaCyc:BETA-ALANOPINE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0016430 biolink:NamedThing tRNA (adenine-N6-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. got7fsn_ti S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity|S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN|EC:2.1.1.55|RHEA:16785 molecular_function owl:Class
GO:0120148 biolink:NamedThing host cell centrosome A structure in a host cell comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. got7fsn_ti host centrosome krc 2018-04-13T15:22:54Z cellular_component owl:Class
GO:0106162 biolink:NamedThing mRNA N-acetyltransferase activity Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate. got7fsn_ti hjd 2018-12-18T19:19:06Z RHEA:58480 molecular_function owl:Class
GO:0018467 biolink:NamedThing formaldehyde dehydrogenase activity Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH. got7fsn_ti glutathione-independent formaldehyde dehydrogenase activity|formaldehyde:NAD+ oxidoreductase activity UM-BBD_reactionID:r0240|MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN|RHEA:16425|EC:1.2.1.46|KEGG_REACTION:R00604 molecular_function owl:Class
GO:0140208 biolink:NamedThing apoptotic process in response to mitochondrial fragmentation Any apoptotic process that occurs as a result of mitochondrial fragmentation. got7fsn_ti apoptosis in response to mitochondrial fragmentation pg 2018-03-08T16:54:17Z biological_process owl:Class
GO:0033441 biolink:NamedThing AAU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AAU codon. got7fsn_ti AAT codon-amino acid adaptor activity|asparagine tRNA Note that in the standard genetic code, AAT codes for asparagine. molecular_function owl:Class
GO:0106256 biolink:NamedThing hydroperoxy icosatetraenoate dehydratase activity A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O. got7fsn_ti hjd 2020-03-20T14:40:16Z RHEA:55556|EC:4.2.1.152 molecular_function owl:Class
GO:0016556 biolink:NamedThing mRNA modification The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically. got7fsn_ti mRNA editing The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. GO:0006381 biological_process owl:Class
GO:0010211 biolink:NamedThing IAA-Leu conjugate hydrolase activity Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine. got7fsn_ti MetaCyc:RXN-2982 molecular_function owl:Class
GO:0043617 biolink:NamedThing cellular response to sucrose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose. got7fsn_ti biological_process owl:Class
GO:0106359 biolink:NamedThing 2-hydroxyacyl-CoA lyase activity Catalysis of the reaction: A 2-hydroxyacyl-CoA = formyl-CoA + a propanol. got7fsn_ti hjd 2021-02-03T16:12:00Z molecular_function owl:Class
GO:0102564 biolink:NamedThing aurachin C epoxide hydrolase/isomerase activity Catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P). got7fsn_ti MetaCyc:RXN-15030|RHEA:48728 molecular_function owl:Class
GO:0045879 biolink:NamedThing negative regulation of smoothened signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. got7fsn_ti negative regulation of smoothened by patched|negative regulation of hedgehog signaling pathway|downregulation of smoothened signaling pathway|negative regulation of smoothened receptor activity by patched|negative regulation of hh signaling pathway|negative regulation of smoothened signalling pathway|down-regulation of smoothened signaling pathway|negative regulation of smoothened activity|down regulation of smoothened signaling pathway|inhibition of smoothened signaling pathway GO:0045877 biological_process owl:Class
GO:0010967 biolink:NamedThing regulation of polyamine biosynthetic process Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. got7fsn_ti tb 2009-05-20T11:45:37Z biological_process owl:Class
GO:0043910 biolink:NamedThing ATP:coenzyme F420 adenylyltransferase activity Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate. got7fsn_ti coenzyme F390-A synthetase activity|ATP:coenzyme F420 adenyltransferase activity MetaCyc:RXN-9385 molecular_function owl:Class
GO:0004122 biolink:NamedThing cystathionine beta-synthase activity Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. got7fsn_ti serine sulfhydrylase activity|L-serine hydro-lyase (adding homocysteine)|L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)|beta-thionase activity|methylcysteine synthase activity|serine sulfhydrase activity RHEA:10112|MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN|EC:4.2.1.22|Reactome:R-HSA-1614524 molecular_function owl:Class
GO:0008267 biolink:NamedThing poly-glutamine tract binding Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein. got7fsn_ti molecular_function owl:Class
GO:1902404 biolink:NamedThing mitotic actomyosin contractile ring contraction Any actomyosin contractile ring contraction that is involved in mitotic cell cycle. got7fsn_ti cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|mitotic actomyosin contractile ring constriction https://github.com/geneontology/go-ontology/issues/21855 jl 2013-09-12T12:27:57Z biological_process owl:Class
GO:0018486 biolink:NamedThing 2-butanone oxidase activity Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate. got7fsn_ti UM-BBD_reactionID:r0169 molecular_function owl:Class
GO:0102756 biolink:NamedThing very-long-chain 3-ketoacyl-CoA synthase activity Catalysis of the reaction: malonyl-CoA + a very-long-chain 2,3,4-saturated fatty acyl CoA = carbon dioxide + coenzyme A + a very-long-chain oxoacyl-CoA. got7fsn_ti MetaCyc:RXN-7697|RHEA:32727|EC:2.3.1.199 molecular_function owl:Class
GO:0046216 biolink:NamedThing indole phytoalexin catabolic process The chemical reactions and pathways resulting in the breakdown of indole phytoalexins, any indole compound produced by plants as part of their defense response. got7fsn_ti indole phytoalexin catabolism|indole phytoalexin breakdown|indole phytoalexin degradation biological_process owl:Class
GO:0032976 biolink:NamedThing release of matrix enzymes from mitochondria The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process. got7fsn_ti release of aspartate aminotransferase from mitochondria|mAST release from mitochondria Annotation to this term should be done with caution, particularly if the mechanism is not well clarified. biological_process owl:Class
GO:2001108 biolink:NamedThing positive regulation of Rho guanyl-nucleotide exchange factor activity Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity. got7fsn_ti positive regulation of RhoGEF|positive regulation of Rho guanine nucleotide exchange factor yaf 2011-09-23T10:13:16Z biological_process owl:Class
GO:1905099 biolink:NamedThing positive regulation of guanyl-nucleotide exchange factor activity Any process that activates or increases the frequency, rate or extent of guanyl-nucleotide exchange factor activity. got7fsn_ti upregulation of guanyl-nucleotide releasing factor|activation of GDS|upregulation of GEF|up-regulation of guanyl-nucleotide releasing factor|upregulation of guanyl-nucleotide exchange factor activity|activation of guanyl-nucleotide releasing factor|activation of GDP-dissociation stimulator activity|up-regulation of GDS|up regulation of GEF|positive regulation of guanyl-nucleotide release factor activity|positive regulation of GDS|upregulation of GDP-dissociation stimulator activity|positive regulation of GEF|up regulation of guanyl-nucleotide release factor activity|up-regulation of GEF|activation of guanyl-nucleotide exchange factor activity|upregulation of GDS|up-regulation of GNRP|upregulation of guanyl-nucleotide release factor activity|activation of guanyl-nucleotide release factor activity|positive regulation of GDP-dissociation stimulator activity|up regulation of guanyl-nucleotide exchange factor activity|up-regulation of guanyl-nucleotide exchange factor activity|upregulation of GNRP|activation of GNRP|up-regulation of guanyl-nucleotide release factor activity|up regulation of GNRP|positive regulation of guanyl-nucleotide releasing factor|up regulation of GDS|up-regulation of GDP-dissociation stimulator activity|up regulation of GDP-dissociation stimulator activity|up regulation of guanyl-nucleotide releasing factor|positive regulation of GNRP|activation of GEF https://github.com/geneontology/go-ontology/issues/18750 sl 2016-03-31T16:09:54Z biological_process owl:Class
GO:1900562 biolink:NamedThing dehydroaustinol catabolic process The chemical reactions and pathways resulting in the breakdown of dehydroaustinol. got7fsn_ti dehydroaustinol catabolism|dehydroaustinol degradation|dehydroaustinol breakdown di 2012-05-15T06:27:55Z biological_process owl:Class
GO:0000711 biolink:NamedThing meiotic DNA repair synthesis During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template. got7fsn_ti biological_process owl:Class
GO:0001605 biolink:NamedThing adrenomedullin receptor activity Combining with adrenomedullin to initiate a change in cell activity. got7fsn_ti G10D receptor molecular_function owl:Class
GO:0050319 biolink:NamedThing tartrate decarboxylase activity Catalysis of the reaction: L-tartrate + H(+) = D-glycerate + CO(2). got7fsn_ti (R,R)-tartrate carboxy-lyase (D-glycerate-forming)|(R,R)-tartrate carboxy-lyase activity MetaCyc:TARTRATE-DECARBOXYLASE-RXN|KEGG_REACTION:R01751|EC:4.1.1.73|RHEA:13317 molecular_function owl:Class
GO:0009242 biolink:NamedThing colanic acid biosynthetic process The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide. got7fsn_ti colanic acid formation|M antigen biosynthetic process|colanic acid synthesis|colanic acid anabolism|colanic acid biosynthesis|M antigen biosynthesis MetaCyc:COLANSYN-PWY biological_process owl:Class
GO:0120201 biolink:NamedThing cone photoreceptor disc membrane Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane. got7fsn_ti krc 2019-05-07T23:17:43Z cellular_component owl:Class
GO:0002115 biolink:NamedThing store-operated calcium entry A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum. got7fsn_ti store-operated calcium import|calcium ion import|capacitative calcium entry|SOCE SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum. biological_process owl:Class
GO:0048678 biolink:NamedThing response to axon injury Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. got7fsn_ti biological_process owl:Class
GO:0015952 biolink:NamedThing purine deoxyribonucleotide interconversion The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide. got7fsn_ti biological_process owl:Class
GO:0072759 biolink:NamedThing cellular response to topoisomerase inhibitor Any process that results in a change in state or activity of a (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus. got7fsn_ti mah 2012-11-09T11:38:08Z biological_process owl:Class
GO:0072758 biolink:NamedThing response to topoisomerase inhibitor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus. got7fsn_ti mah 2012-11-09T11:34:51Z biological_process owl:Class
GO:0046538 biolink:NamedThing 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate; this reaction requires the cofactor 2,3-bisphosphoglycerate. got7fsn_ti glycerate phosphomutase (diphosphoglycerate cofactor) activity|PGAM-d molecular_function owl:Class
GO:0046754 biolink:NamedThing viral exocytosis The exit of enveloped or unenveloped virion particles from the host cell by exocytosis, without causing cell lysis. got7fsn_ti biological_process owl:Class
GO:0030654 biolink:NamedThing beta-lactam antibiotic biosynthetic process The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins. got7fsn_ti beta-lactam antibiotic anabolism|beta-lactam antibiotic synthesis|beta-lactam antibiotic biosynthesis|beta-lactam antibiotic formation biological_process owl:Class
GO:0004778 biolink:NamedThing succinyl-CoA hydrolase activity Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate. got7fsn_ti succinyl coenzyme A deacylase activity|succinyl coenzyme A hydrolase activity|succinyl-CoA acylase activity MetaCyc:SUCCINYL-COA-HYDROLASE-RXN|RHEA:11516|EC:3.1.2.3|KEGG_REACTION:R00407 molecular_function owl:Class
GO:0140529 biolink:NamedThing CMG complex assembly The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16570 pg 2020-10-12T16:42:17Z biological_process owl:Class
GO:0060312 biolink:NamedThing regulation of blood vessel remodeling Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. got7fsn_ti biological_process owl:Class
GO:0004438 biolink:NamedThing phosphatidylinositol-3-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. got7fsn_ti inositol-1,3-bisphosphate 3-phosphatase activity|inositol-polyphosphate 3-phosphatase activity|phosphatidyl-3-phosphate 3-phosphohydrolase activity|D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity|inositol 1,3-bisphosphate phosphatase activity|inositol-1,4,-bisphosphate 3-phosphatase activity|1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity Note that this function includes EC:3.1.3.65. GO:0016315 Reactome:R-HSA-1675795|Reactome:R-HSA-6809720|Reactome:R-HSA-1676141|MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN|RHEA:12316|Reactome:R-HSA-6809777|Reactome:R-HSA-1675994|Reactome:R-HSA-6809975|Reactome:R-HSA-6809325|Reactome:R-HSA-1676114|EC:3.1.3.64 molecular_function owl:Class
GO:0102890 biolink:NamedThing naringenin chalcone 4'-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 2',4,4',6'-tetrahydroxychalcone <=> UDP + 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + H+. got7fsn_ti EC:2.4.1.286|RHEA:34291|MetaCyc:RXN-8453 molecular_function owl:Class
GO:0031960 biolink:NamedThing response to corticosteroid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids. got7fsn_ti response to corticosteroid stimulus biological_process owl:Class
GO:0103026 biolink:NamedThing fructose-1-phosphatase activity Catalysis of the reaction: beta-D-fructofuranose 1-phosphate + H2O <=> beta-D-fructofuranose + hydrogenphosphate. got7fsn_ti RHEA:35603|MetaCyc:RXN0-5186 molecular_function owl:Class
GO:0004965 biolink:NamedThing G protein-coupled GABA receptor activity Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G-protein coupled GABA receptor activity|metabotropic GABA receptor|GABA-B receptor activity Reactome:R-HSA-1013013|Reactome:R-HSA-1013012 molecular_function owl:Class
GO:0047173 biolink:NamedThing phosphatidylcholine-retinol O-acyltransferase activity Catalysis of the reaction: retinol-[cellular-retinol-binding-protein] + phosphatidylcholine = retinyl-ester-[cellular-retinol-binding-protein] + 2-acylglycerophosphocholine. got7fsn_ti phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase activity|lecithin--retinol acyltransferase activity|phosphatidylcholine:retinol-[cellular-retinol-binding-protein] O-acyltransferase activity MetaCyc:2.3.1.135-RXN|RHEA:17469|EC:2.3.1.135|Reactome:R-HSA-975608 molecular_function owl:Class
GO:0018954 biolink:NamedThing pentaerythritol tetranitrate metabolic process The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator. got7fsn_ti pentaerythritol tetranitrate metabolism UM-BBD_pathwayID:petn biological_process owl:Class
GO:0033637 biolink:NamedThing modulation by symbiont of host response to cold Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti freezing tolerance biological_process owl:Class
GO:0033636 biolink:NamedThing modulation by symbiont of host response to temperature stimulus Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of host response to thermal stimulus biological_process owl:Class
GO:0070440 biolink:NamedThing Mad-Max-mSin3B complex A transcriptional repressor complex that contains a heterodimer of the bHLH-ZIP proteins Mad and Max, plus mSin3B, a homolog of the yeast Sin3p. got7fsn_ti cellular_component owl:Class
GO:0047979 biolink:NamedThing hexose oxidase activity Catalysis of the reaction: hexose + O2 = aldono-1,5-lactone + H202. got7fsn_ti D-hexose:oxygen 1-oxidoreductase activity EC:1.1.3.5|MetaCyc:HEXOSE-OXIDASE-RXN molecular_function owl:Class
GO:0031153 biolink:NamedThing slug development involved in sorocarp development The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development. got7fsn_ti standing slug development during sorocarp development|slug development during fruiting body development|pseudoplasmodium formation|migratory slug development during sorocarp development|slug development during sorocarp development|pseudoplasmodium biosynthesis biological_process owl:Class
GO:0051221 biolink:NamedThing tungsten incorporation into metallo-sulfur cluster The incorporation of tungsten into a metallo-sulfur cluster. got7fsn_ti tungsten incorporation into metallo-sulphur cluster biological_process owl:Class
GO:0106263 biolink:NamedThing 1-acylglycerophosphoserine O-acyltransferase activity Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA. got7fsn_ti hjd 2020-05-18T15:12:42Z RHEA:33191 molecular_function owl:Class
GO:0030738 biolink:NamedThing tyramine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+). got7fsn_ti tyramine methylpherase activity|DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)|S-adenosyl-L-methionine:tyramine N-methyltransferase activity|S-adenosyl-methionine:tyramine N-methyltransferase activity MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN|RHEA:14865|EC:2.1.1.27|KEGG_REACTION:R02384 molecular_function owl:Class
GO:0051627 biolink:NamedThing negative regulation of epinephrine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of epinephrine into a cell. got7fsn_ti down regulation of epinephrine uptake|negative regulation of epinephrine import|down-regulation of epinephrine uptake|downregulation of epinephrine uptake|negative regulation of adrenaline uptake biological_process owl:Class
GO:0071730 biolink:NamedThing beak formation The process that gives rise to the beak. This process pertains to the initial formation of a structure from unspecified parts. The avian beak is an external anatomical structure, in the head region, that is adapted for feeding self and young, catching prey, probing, etc. It encompasses, but is not restricted to, the maxilla, mandible, maxillary rhamphotheca, mandibular rhamphotheca, nostril, nasal fossa, nasal bones, egg tooth and rictus. got7fsn_ti mah 2010-03-17T03:57:07Z biological_process owl:Class
GO:1990915 biolink:NamedThing structural constituent of ascospore wall The action of a molecule that contributes to the structural integrity of an ascospore wall. got7fsn_ti al 2015-12-09T19:04:53Z molecular_function owl:Class
GO:0034302 biolink:NamedThing akinete formation The process in which an akinete, a thick-walled (encysted) dormant cell derived from the enlargement of a vegetative cell, is formed. Akinetes typically have granular cytoplasm, are more resistant to environmental extremes than vegetative cells, and are characteristic of several groups of Cyanobacteria. got7fsn_ti biological_process owl:Class
GO:0034909 biolink:NamedThing 6-hydroxypseudooxynicotine dehydrogenase activity Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine. got7fsn_ti UM-BBD_reactionID:r1441|RHEA:34223|EC:1.5.99.14 molecular_function owl:Class
GO:0102156 biolink:NamedThing 2,5-DHBA UDP-glucosyltransferase activity Catalysis of the reaction: 2,5-dihydroxybenzoate + UDP-alpha-D-glucose <=> 2,5-dihydroxybenzoate 5-O-beta-D-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-11705 molecular_function owl:Class
GO:0042966 biolink:NamedThing biotin carboxyl carrier protein biosynthetic process The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase. got7fsn_ti BCCP biosynthesis|biotin carboxyl carrier protein formation|biotin carboxyl carrier protein anabolism|biotin carboxyl carrier protein biosynthesis|BCCP biosynthetic process|biotin carboxyl carrier protein synthesis biological_process owl:Class
GO:0102133 biolink:NamedThing limonene hydroxylase activity Catalysis of the reaction: (4R)-limonene + O2 + NADH + H+ <=> (4R)-perillyl alcohol + NAD + H2O. got7fsn_ti MetaCyc:RXN-11493 molecular_function owl:Class
GO:0034362 biolink:NamedThing low-density lipoprotein particle A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver. got7fsn_ti LDL particle|LDL complex|low-density lipoprotein complex cellular_component owl:Class
GO:1900772 biolink:NamedThing fumitremorgin B biosynthetic process The chemical reactions and pathways resulting in the formation of fumitremorgin B. got7fsn_ti Lanosulin formation|fumitremorgin B biosynthesis|fumitremorgin B formation|Lanosulin biosynthetic process|Lanosulin anabolism|Lanosulin synthesis|fumitremorgin B synthesis|fumitremorgin B anabolism|Lanosulin biosynthesis di 2012-06-04T09:25:50Z biological_process owl:Class
GO:0031683 biolink:NamedThing G-protein beta/gamma-subunit complex binding Binding to a complex of G-protein beta/gamma subunits. got7fsn_ti molecular_function owl:Class
GO:0036372 biolink:NamedThing opsin transport The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. got7fsn_ti ciliary transport of opsin bf 2013-04-23T09:26:29Z biological_process owl:Class
GO:0048173 biolink:NamedThing positive regulation of short-term neuronal synaptic plasticity A process that increases short-term neuronal synaptic plasticity, the ability of neuronal synapses to change in the short-term as circumstances require. Short-term neuronal synaptic plasticity generally involves increasing or decreasing synaptic sensitivity. got7fsn_ti upregulation of short-term neuronal synaptic plasticity|activation of short-term neuronal synaptic plasticity|up-regulation of short-term neuronal synaptic plasticity|up regulation of short-term neuronal synaptic plasticity|stimulation of short-term neuronal synaptic plasticity Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. biological_process owl:Class
GO:0005978 biolink:NamedThing glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. got7fsn_ti glycogen biosynthesis|glycogen formation|glycogen anabolism|glycogen synthesis MetaCyc:GLYCOGENSYNTH-PWY biological_process owl:Class
GO:0103074 biolink:NamedThing glucose-6-phosphate 3-dehydrogenase activity Catalysis of the reaction: NAD + D-glucopyranose 6-phosphate = NADH + H+ + 3-dehydro-D-glucose 6-phosphate. got7fsn_ti EC:1.1.1.361|MetaCyc:RXN8J2-136|RHEA:37547 molecular_function owl:Class
GO:0031004 biolink:NamedThing potassium ion-transporting ATPase complex Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex. got7fsn_ti Kdp system complex cellular_component owl:Class
GO:0043214 biolink:NamedThing ABC-type bacteriocin transporter activity Enables the transfer of a bacteriocin from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. got7fsn_ti ATPase-coupled bacteriocin transmembrane transporter activity|ABC-type bacteriocin transmembrane transporter activity|bacteriocin ABC transporter molecular_function owl:Class
GO:0043449 biolink:NamedThing cellular alkene metabolic process The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells. got7fsn_ti alkene metabolism biological_process owl:Class
GO:0050369 biolink:NamedThing [tyrosine 3-monooxygenase] kinase activity Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]. got7fsn_ti tyrosine 3-monooxygenase kinase (phosphorylating) activity|tyrosine 3-monooxygenase kinase activity|ATP:tyrosine-3-monoxygenase phosphotransferase activity|STK4|pheochromocytoma tyrosine hydroxylase-associated kinase activity MetaCyc:2.7.11.6-RXN|RHEA:17133|EC:2.7.11.6 molecular_function owl:Class
GO:0009421 biolink:NamedThing bacterial-type flagellum filament cap The proteinaceous structure at the distal tip of the bacterial-type flagellar filament. got7fsn_ti flagellin-based flagellum filament cap|flagellar filament cap cellular_component owl:Class
GO:0010838 biolink:NamedThing positive regulation of keratinocyte proliferation Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class
GO:0034403 biolink:NamedThing alignment of 3' and 5' splice sites of mRNA Recognition of both the 5' and 3'-splice sites and positioning them in the correct alignment with respect to each other so that the second catalytic step of nuclear mRNA splicing can occur. got7fsn_ti alignment of 3' and 5' splice sites of nuclear mRNA biological_process owl:Class
GO:0070049 biolink:NamedThing endobrevin-SNAP-25-syntaxin-2 complex A SNARE complex that contains endobrevin (VAMP8), SNAP-25, and syntaxin 2 (or orthologs thereof). got7fsn_ti SNARE complex (Stx2, Snap25, Vamp8)|Stx2-Snap25-Vamp8 complex cellular_component owl:Class
GO:0031836 biolink:NamedThing neuromedin K receptor binding Binding to a neuromedin K receptor. got7fsn_ti neuromedin K receptor ligand|neurokinin-B receptor binding molecular_function owl:Class
GO:0071522 biolink:NamedThing ureidoglycine aminohydrolase activity Catalysis of the reaction: ureidoglycine + H2O = S-ureidoglycolate + NH3. got7fsn_ti mah 2010-01-07T01:43:58Z EC:3.5.3.26|RHEA:25241|MetaCyc:URUR-RXN molecular_function owl:Class
GO:0004470 biolink:NamedThing malic enzyme activity Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. got7fsn_ti pyruvic-malic carboxylase activity molecular_function owl:Class
GO:0042567 biolink:NamedThing insulin-like growth factor ternary complex A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development. got7fsn_ti IGF ternary complex cellular_component owl:Class
GO:0031216 biolink:NamedThing neopullulanase activity Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose). got7fsn_ti pullulan 4-D-glucanohydrolase (panose-forming)|pullulanase II activity EC:3.2.1.135|MetaCyc:3.2.1.135-RXN molecular_function owl:Class
GO:0039602 biolink:NamedThing suppression by virus of host transcription initiation from RNA polymerase II promoter Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template. got7fsn_ti suppression by virus of host DNA-dependent transcription, initiation|inhibition of host transcription initiation by virus bf 2012-07-05T03:29:34Z GO:0039601 VZ:904 biological_process owl:Class
GO:0071381 biolink:NamedThing cellular response to prostaglandin F stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus. got7fsn_ti mah 2009-12-11T03:34:57Z biological_process owl:Class
GO:0061843 biolink:NamedThing Sertoli cell barrier remodeling The tissue remodeling process by which the Sertoli cell barrier is temporarily disrupted and reorganized to accommodate the transit of preleptotene spermatocytes at stage VIII of the epithelial cycle. got7fsn_ti restructuring of SCB|blood testis barrier restructuring|restructuring of BTB|SCB remodeling|restructuring of blood-testis barrier|Sertoli cell barrier restructuring biological_process owl:Class
GO:0031731 biolink:NamedThing CCR6 chemokine receptor binding Binding to a CCR6 chemokine receptor. got7fsn_ti LARC receptor binding|CCR6 chemokine receptor ligand molecular_function owl:Class
GO:0070337 biolink:NamedThing 3'-flap-structured DNA binding Binding to a 3'-flap structure in DNA. A DNA flap structure is one in which a single-stranded 3'-end of DNA or RNA protrudes from a double-stranded DNA molecule. got7fsn_ti molecular_function owl:Class
GO:0001734 biolink:NamedThing mRNA (N6-adenosine)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U. got7fsn_ti Reactome:R-HSA-72095 molecular_function owl:Class
GO:0047557 biolink:NamedThing 3-aci-nitropropanoate oxidase activity Catalysis of the reaction: 3-aci-nitropropanoate + H(2)O + O(2) = 3-oxopropanoate + H(2)O(2) + nitrite. got7fsn_ti 3-aci-nitropropanoate:oxygen oxidoreductase activity|propionate-3-nitronate oxidase activity KEGG_REACTION:R01609|EC:1.7.3.5|MetaCyc:3-ACI-NITROPROPANOATE-OXIDASE-RXN|RHEA:22372 molecular_function owl:Class
GO:0015771 biolink:NamedThing trehalose transport The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. got7fsn_ti biological_process owl:Class
GO:0097252 biolink:NamedThing oligodendrocyte apoptotic process Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons. got7fsn_ti oligodendrocyte apoptosis pr 2012-03-05T10:51:15Z biological_process owl:Class
GO:0004971 biolink:NamedThing AMPA glutamate receptor activity An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium. got7fsn_ti AMPA receptor activity|alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. molecular_function owl:Class
GO:1903213 biolink:NamedThing protein localization to subtelomeric heterochromatin A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin. got7fsn_ti protein localisation to telomeric heterochromatin|protein localisation to subtelomeric heterochromatin|protein localisation in subtelomeric heterochromatin|protein localization in subtelomeric heterochromatin|protein localization to telomeric heterochromatin mah 2013-07-31T15:04:26Z GO:1990152 biological_process owl:Class
GO:0097265 biolink:NamedThing 5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity Catalysis of the reaction: 5-HETE + NADP(+) = 5-oxo-ETE + NADPH + H(+). got7fsn_ti 5(S)-HETE dehydrogenase activity|5-hydroxy-eicosatetraenoic acid dehydrogenase activity|5-HETE dehydrogenase activity pr 2012-03-09T12:46:02Z Reactome:R-HSA-2161776 molecular_function owl:Class
GO:0043442 biolink:NamedThing acetoacetic acid catabolic process The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH. got7fsn_ti acetoacetic acid breakdown|acetoacetic acid catabolism|acetoacetic acid degradation biological_process owl:Class
GO:0019626 biolink:NamedThing short-chain fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6. got7fsn_ti short-chain fatty acid degradation|short-chain fatty acid catabolism|short-chain fatty acid breakdown MetaCyc:ACETOACETATE-DEG-PWY biological_process owl:Class
GO:0009879 biolink:NamedThing determination of radial symmetry The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis. got7fsn_ti determination of radial asymmetry biological_process owl:Class
GO:0070052 biolink:NamedThing collagen V binding Binding to a type V collagen trimer. got7fsn_ti molecular_function owl:Class
GO:0005518 biolink:NamedThing collagen binding Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). got7fsn_ti molecular_function owl:Class
GO:0102258 biolink:NamedThing 1,3-diacylglycerol acylhydrolase activity Catalysis of the reaction: H2O + a 1,3-diglyceride = a monoglyceride + a fatty acid. got7fsn_ti MetaCyc:RXN-12433 molecular_function owl:Class
GO:0051409 biolink:NamedThing response to nitrosative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. got7fsn_ti biological_process owl:Class
GO:1990353 biolink:NamedThing Fused-Smurf ubiquitin ligase complex A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation. got7fsn_ti An example of this is FUSED in Drosophila melanogaster (UniProt symbol P23647) in PMID:21145463 (inferred from direct assay). bhm 2014-03-27T14:02:09Z cellular_component owl:Class
GO:0047230 biolink:NamedThing flavonol-3-O-glucoside L-rhamnosyltransferase activity Catalysis of the reaction: flavonol 3-O-D-glucoside + UDP-L-rhamnose = flavonol 3-O-L-rhamnosylglucoside + UDP. got7fsn_ti UDP-L-rhamnose:flavonol-3-O-D-glucoside 6''-O-L-rhamnosyltransferase activity|uridine diphosphorhamnose-flavonol 3-O-glucoside rhamnosyltransferase activity|UDP-rhamnose:flavonol 3-O-glucoside rhamnosyltransferase activity MetaCyc:2.4.1.159-RXN|EC:2.4.1.159|RHEA:22528 molecular_function owl:Class
GO:1904269 biolink:NamedThing cell leading edge cell cortex The cell cortex of the leading edge of a cell. got7fsn_ti peripheral cytoplasm of cell leading edge|cell cortex of leading edge of cell|cell periphery of leading edge of cell|cell cortex of cell leading edge|cell cortex of front of cell|peripheral cytoplasm of front of cell|cell periphery of cell leading edge|peripheral cytoplasm of leading edge of cell|cell periphery of front of cell kmv 2015-05-28T19:16:03Z cellular_component owl:Class
GO:0048772 biolink:NamedThing leucophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance. got7fsn_ti leucophore cell differentiation biological_process owl:Class
GO:0140380 biolink:NamedThing psilocybin biosynthetic process The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product. got7fsn_ti pg 2019-11-20T10:03:05Z biological_process owl:Class
GO:0052600 biolink:NamedThing propane-1,3-diamine oxidase activity Catalysis of the reaction: propane-1,3-diamine + H2O + O2 = 3-aminopropanal + NH3 + hydrogen peroxide + H+. got7fsn_ti trimethylenediamine oxidase activity|propane-1,3-diamine:oxygen oxidoreductase (deaminating) activity|1,3-diaminopropane oxidase activity KEGG_REACTION:R03139|EC:1.4.3.22|MetaCyc:RXN-6381|RHEA:30895 molecular_function owl:Class
GO:0002433 biolink:NamedThing immune response-regulating cell surface receptor signaling pathway involved in phagocytosis An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes. got7fsn_ti immune response-regulating cell surface receptor signalling pathway involved in phagocytosis|phagocytosis triggered by activation of immune response cell surface activating receptor biological_process owl:Class
GO:0043993 biolink:NamedThing histone acetyltransferase activity (H3-K18 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K18 specific) molecular_function owl:Class
GO:0051479 biolink:NamedThing mannosylglycerate biosynthetic process The chemical reactions and pathways resulting in the formation of mannosylglycerate, a very common compatible solute in thermophilic and hyperthermophilic organisms. got7fsn_ti mannosylglycerate formation|mannosylglycerate anabolism|mannosylglycerate synthesis|mannosylglycerate biosynthesis biological_process owl:Class
GO:0031823 biolink:NamedThing type 1D serotonin receptor binding Binding to a type 1D serotonin receptor. got7fsn_ti type 1D serotonin receptor ligand|5-hydroxytryptamine 1D receptor binding molecular_function owl:Class
GO:0071275 biolink:NamedThing cellular response to aluminum ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. got7fsn_ti cellular response to aluminum|cellular response to aluminium ion mah 2009-12-10T03:52:20Z biological_process owl:Class
GO:0102729 biolink:NamedThing 6-oxocampestanol hydroxylase activity Catalysis of the reaction: H+ + 6-oxocampestanol + O2 + NADPH = cathasterone + H2O + NADP. got7fsn_ti MetaCyc:RXN-715 molecular_function owl:Class
GO:0060510 biolink:NamedThing type II pneumocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a type II pneumocyte. A type II pneumocyte is a surfactant secreting cell that contains abundant cytoplasm containing numerous lipid-rich multilamellar bodies. got7fsn_ti great alveolar cell differentiation|large alveolar cell differentiation|granular pneumocyte differentiation biological_process owl:Class
GO:0044313 biolink:NamedThing protein K6-linked deubiquitination A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein. got7fsn_ti jl 2010-06-01T03:10:11Z biological_process owl:Class
GO:0035842 biolink:NamedThing old cell tip after activation of bipolar cell growth A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures. got7fsn_ti post-new end take-off old cell tip|post-NETO old cell tip|post-NETO old cell end bf 2011-05-06T01:37:23Z cellular_component owl:Class
GO:0035840 biolink:NamedThing old growing cell tip A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures. got7fsn_ti old growing cell end bf 2011-05-06T01:33:54Z cellular_component owl:Class
GO:0033543 biolink:NamedThing fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). got7fsn_ti biological_process owl:Class
GO:0010012 biolink:NamedThing steroid 22-alpha hydroxylase activity Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O. got7fsn_ti molecular_function owl:Class
GO:0047888 biolink:NamedThing fatty acid peroxidase activity Catalysis of the reaction: 2 H(2)O(2) + H(+) + palmitate = CO(2) + 3 H(2)O + pentadecanal. got7fsn_ti fatty-acid peroxidase activity|long chain fatty acid peroxidase activity|hexadecanoate:hydrogen-peroxide oxidoreductase activity RHEA:23960|KEGG_REACTION:R01703|MetaCyc:FATTY-ACID-PEROXIDASE-RXN|EC:1.11.1.3 molecular_function owl:Class
GO:0034730 biolink:NamedThing SmD-containing SMN-Sm protein complex An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D1, D2, D3, E, F, and G with the SMN complex. got7fsn_ti SMN-containing protein complex cellular_component owl:Class
GO:0071330 biolink:NamedThing cellular response to trehalose-6-phosphate stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus. got7fsn_ti mah 2009-12-10T05:32:52Z biological_process owl:Class
GO:0080094 biolink:NamedThing response to trehalose-6-phosphate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose-6-phosphate stimulus. got7fsn_ti response to trehalose-6-phosphate stimulus dhl 2009-04-22T04:49:13Z biological_process owl:Class
GO:0097008 biolink:NamedThing (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone. got7fsn_ti (3E)-4,8-dimethylnona-1,3,7-triene synthase activity|DNMT synthase activity pr 2011-03-17T10:38:01Z MetaCyc:RXN-8619 molecular_function owl:Class
GO:0014893 biolink:NamedThing response to rest involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation. got7fsn_ti biological_process owl:Class
GO:0042122 biolink:NamedThing alginic acid catabolic process The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds). got7fsn_ti alginic acid catabolism|alginic acid degradation|alginate catabolic process|alginic acid breakdown|alginate catabolism biological_process owl:Class
GO:0042625 biolink:NamedThing ATPase-coupled ion transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. got7fsn_ti ATPase coupled ion transmembrane transporter activity|ATPase activity, coupled to transmembrane movement of ions|ATP-dependent ion transmembrane transporter activity molecular_function owl:Class
GO:0050105 biolink:NamedThing L-gulonolactone oxidase activity Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2. got7fsn_ti L-gulono-gamma-lactone oxidase activity|L-gulono-1,4-lactone:oxygen 3-oxidoreductase activity|L-gulono-gamma-lactone:O2 oxidoreductase activity|GLO activity|L-gulono-gamma-lactone:oxidoreductase activity MetaCyc:L-GULONOLACTONE-OXIDASE-RXN|RHEA:32363|EC:1.1.3.8 molecular_function owl:Class
GO:0006727 biolink:NamedThing ommochrome biosynthetic process The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye. got7fsn_ti ommochrome anabolism|ommochrome formation|ommochrome synthesis|ommochrome biosynthesis biological_process owl:Class
GO:0061072 biolink:NamedThing iris morphogenesis The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina. got7fsn_ti dph 2010-03-16T10:48:42Z biological_process owl:Class
GO:0034706 biolink:NamedThing sodium channel complex An ion channel complex through which sodium ions pass. got7fsn_ti cellular_component owl:Class
GO:0044644 biolink:NamedThing envenomation resulting in negative regulation of complement activation, alternative pathway in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism. got7fsn_ti jl 2012-07-11T12:35:11Z biological_process owl:Class
GO:0051687 biolink:NamedThing maintenance of spindle location Any process in which the spindle is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of spindle localization biological_process owl:Class
GO:1905554 biolink:NamedThing negative regulation of vessel branching Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching. got7fsn_ti downregulation of patterning of blood vessels|inhibition of patterning of blood vessels|down-regulation of branching involved in blood vessel morphogenesis|negative regulation of branching involved in blood vessel morphogenesis|down-regulation of patterning of blood vessels|down regulation of patterning of blood vessels|inhibition of branching involved in blood vessel morphogenesis|down regulation of branching involved in blood vessel morphogenesis|downregulation of branching involved in blood vessel morphogenesis nc 2016-10-12T14:19:41Z biological_process owl:Class
GO:0071020 biolink:NamedThing post-spliceosomal complex A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, including U5. got7fsn_ti yeast spliceosomal complex A2-3|mammalian spliceosomal complex C2 mah 2009-07-30T12:00:35Z cellular_component owl:Class
GO:0030753 biolink:NamedThing 8-hydroxyfuranocoumarin 8-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin. got7fsn_ti furanocoumarin 8-methyltransferase activity|xanthotoxol 8-O-methyltransferase activity|xanthotoxol O-methyltransferase activity|S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity|furanocoumarin 8-O-methyl-transferase activity|xanthotoxol methyltransferase activity|XMT activity|S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity|S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity GO:0030765 KEGG_REACTION:R02982|EC:2.1.1.70 molecular_function owl:Class
GO:0019405 biolink:NamedThing alditol catabolic process The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group. got7fsn_ti alditol breakdown|alditol catabolism|alditol degradation biological_process owl:Class
GO:0080054 biolink:NamedThing low-affinity nitrate transmembrane transporter activity Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. got7fsn_ti low affinity nitrate transmembrane transporter activity molecular_function owl:Class
GO:0003681 biolink:NamedThing bent DNA binding Binding to DNA in a bent conformation. got7fsn_ti molecular_function owl:Class
GO:0019229 biolink:NamedThing regulation of vasoconstriction Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels. got7fsn_ti biological_process owl:Class
GO:0047698 biolink:NamedThing beta-alanyl-CoA ammonia-lyase activity Catalysis of the reaction: beta-alanyl-CoA = acryloyl-CoA + NH3. got7fsn_ti b-alanyl-CoA ammonia-lyase activity|beta-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming)|beta-alanyl coenzyme A ammonia-lyase activity MetaCyc:BETA-ALANYL-COA-AMMONIA-LYASE-RXN|EC:4.3.1.6|RHEA:12416 molecular_function owl:Class
GO:1990146 biolink:NamedThing protein localization to rhabdomere A process in which a protein is transported to, or maintained in, a location within a rhabdomere. got7fsn_ti sart 2013-07-25T11:24:49Z biological_process owl:Class
GO:0060566 biolink:NamedThing positive regulation of DNA-templated transcription, termination Any process that increases the rate, frequency or extent of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. got7fsn_ti positive regulation of DNA-dependent transcription, termination|positive regulation of termination of DNA-dependent transcription|positive regulation of transcription termination, DNA-dependent dph 2009-04-29T02:54:50Z biological_process owl:Class
GO:0106389 biolink:NamedThing ecdysteroid 22-kinase activity Catalysis of the reaction: an ecdysteroid + ATP = an ecdysteroid 22-phosphate + ADP + H+. got7fsn_ti hjd 2021-07-13T14:37:23Z MetaCyc:RXN-14755 molecular_function owl:Class
GO:0036024 biolink:NamedThing protein C inhibitor-TMPRSS7 complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7. got7fsn_ti plasma serine protease inhibitor-TMPRSS7 complex|protein C inhibitor-matriptase-3 complex|PCI-TMPRSS7 complex|protein C inhibitor-transmembrane protease serine 7 complex|serpin A5-TMPRSS7 complex|SERPINA5-TMPRSS7 complex bf 2011-10-19T01:25:06Z cellular_component owl:Class
GO:0062244 biolink:NamedThing double membrane vesicle viral factory lumen The volume surrounded by the inner membrane of a double membrane vesicle viral factory. got7fsn_ti lumen of double membrane vesicle viral factory dph 2020-04-20T20:53:30Z cellular_component owl:Class
GO:0043751 biolink:NamedThing polyphosphate:AMP phosphotransferase activity Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP. got7fsn_ti PPT|PAP molecular_function owl:Class
GO:0060234 biolink:NamedThing neuroblast delamination The negative regulation of cell adhesion process in which a neuroblast splits off of a neurectodermal sheet. got7fsn_ti biological_process owl:Class
GO:0031346 biolink:NamedThing positive regulation of cell projection organization Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections. got7fsn_ti stimulation of cell projection organization|positive regulation of cell projection organization and biogenesis|up regulation of cell projection organization|positive regulation of cell projection organisation|upregulation of cell projection organization|activation of cell projection organization|up-regulation of cell projection organization biological_process owl:Class
GO:0140491 biolink:NamedThing ubiquitin-like hydrolase activity An activity that cleaves ubiquitin or ubiquitin-like proteins (ULP) from target proteins. got7fsn_ti ubiquitinyl-like hydrolase activity https://github.com/geneontology/go-ontology/issues/17398 pg 2020-07-01T12:37:19Z molecular_function owl:Class
GO:0047759 biolink:NamedThing butanal dehydrogenase activity Catalysis of the reaction: butanal + CoA + NAD(P)+ = butanoyl-CoA + NAD(P)H + H+. got7fsn_ti butanal:NAD(P)+ oxidoreductase (CoA-acylating) EC:1.2.1.57|MetaCyc:BUTANAL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0099128 biolink:NamedThing mitochondrial iron-sulfur cluster assembly complex A protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine. got7fsn_ti cellular_component owl:Class
GO:0043509 biolink:NamedThing activin A complex A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A). got7fsn_ti Note that the actions of the activin complex are the opposite of those of the inhibin complex, which is a dimer of an inhibin beta-A or inhibin beta-B subunit and an inhibin alpha subunit. See also the cellular component term 'inhibin complex ; GO:0043511'. GO:0048181 cellular_component owl:Class
GO:0072214 biolink:NamedThing metanephric cortex development The process whose specific outcome is the progression of the metanephric cortex over time, from its formation to the mature structure. The metanephric cortex is the outer region of the metanephros. got7fsn_ti mah 2010-03-18T01:29:49Z biological_process owl:Class
GO:0085033 biolink:NamedThing induction by symbiont of host I-kappaB kinase/NF-kappaB cascade Any process that activates or increases the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti activation by symbiont of host I-kappaB kinase/NF-kappaB cascade|up-regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|positive regulation by symbiont of nuclear factor kappa-light-chain-enhancer of activated B cells mediated signal transduction pathway|up regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|positive regulation by symbiont of host NF-kappaB-mediated signal transduction pathway|upregulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|stimulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|positive regulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|induction by symbiont of host I-kappaB kinase/NF-kappaB cascade jl 2010-07-27T02:47:01Z biological_process owl:Class
GO:0043123 biolink:NamedThing positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. got7fsn_ti up regulation of I-kappaB kinase/NF-kappaB cascade|up-regulation of I-kappaB kinase/NF-kappaB cascade|upregulation of I-kappaB kinase/NF-kappaB cascade|activation of I-kappaB kinase/NF-kappaB cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|stimulation of I-kappaB kinase/NF-kappaB cascade biological_process owl:Class
GO:0033565 biolink:NamedThing ESCRT-0 complex A protein complex required for the recycling of Golgi proteins, formation of lumenal membranes and sorting of ubiquitinated proteins into those membranes. This complex includes Vps1p and Hse1p in yeast and the Hrs and STAM proteins in mammals. got7fsn_ti Hrs/STAM complex|Vps27p-Hse1p complex cellular_component owl:Class
GO:0046568 biolink:NamedThing 3-methylbutanol:NAD(P) oxidoreductase activity Catalysis of the reaction: 3-methylbutanol + NAD(P)+ = 3-methylbutanal + NAD(P)H + H+. 3-methylbutanal is also known as isovaleraldehyde. got7fsn_ti 3-methylbutanal reductase [NAD(P)] activity|3-methylbutyraldehyde reductase activity|isoamyl alcohol oxidase activity EC:1.1.1.265|MetaCyc:1.1.1.265-RXN molecular_function owl:Class
GO:0003827 biolink:NamedThing alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP. got7fsn_ti GNTI activity|N-acetylglucosaminyltransferase I activity|UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity|UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity|alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity|GnTI|uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity EC:2.4.1.101|RHEA:11456|MetaCyc:2.4.1.101-RXN|Reactome:R-HSA-964768|KEGG_REACTION:R05983 molecular_function owl:Class
GO:0102150 biolink:NamedThing 3-oxo-myristoyl-CoA hydrolase activity Catalysis of the reaction: 3-oxotetradecanoyl-CoA + H2O <=> 3-oxo-myristate + coenzyme A + H+. got7fsn_ti MetaCyc:RXN-11668 molecular_function owl:Class
GO:0071292 biolink:NamedThing cellular response to silver ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus. got7fsn_ti mah 2009-12-10T04:16:30Z biological_process owl:Class
GO:0010272 biolink:NamedThing response to silver ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus. got7fsn_ti biological_process owl:Class
GO:0102335 biolink:NamedThing N,N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase activity Catalysis of the reaction: N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP-N-acetyl-D-galactosamine <=> N-acetyl-D-galactosaminyl-alpha-(1->3)-N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UDP + H+. got7fsn_ti MetaCyc:RXN-13274|RHEA:34511|EC:2.4.1.290 molecular_function owl:Class
GO:0019827 biolink:NamedThing stem cell population maintenance The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types. got7fsn_ti maintenance of pluripotency biological_process owl:Class
GO:0090175 biolink:NamedThing regulation of establishment of planar polarity Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates. got7fsn_ti tb 2009-12-14T10:29:41Z biological_process owl:Class
GO:0030199 biolink:NamedThing collagen fibril organization Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix. got7fsn_ti collagen fibril organisation|fibrillar collagen organization biological_process owl:Class
GO:0043448 biolink:NamedThing alkane catabolic process The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2. got7fsn_ti alkane breakdown|alkane catabolism|alkane degradation biological_process owl:Class
GO:0010274 biolink:NamedThing hydrotropism Growth or movement in a sessile organism toward or away from water, as of the roots of a plant. got7fsn_ti Wikipedia:Hydrotropism biological_process owl:Class
GO:0051031 biolink:NamedThing tRNA transport The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0016720 biolink:NamedThing delta12-fatty acid dehydrogenase activity Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O. got7fsn_ti delta-12 fatty acid acetylenase activity|crepenynate synthase activity|linoleate delta-12-fatty acid acetylenase (desaturase) activity|linoleate delta12-fatty acid acetylenase (desaturase)|delta12 fatty acid acetylenase activity|D12-fatty acid dehydrogenase activity|linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating) RHEA:23456|KEGG_REACTION:R05740|EC:1.14.99.33|MetaCyc:1.14.99.33-RXN molecular_function owl:Class
GO:0000286 biolink:NamedThing alanine dehydrogenase activity Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+). got7fsn_ti alanine oxidoreductase activity|L-alanine:NAD+ oxidoreductase (deaminating)|alpha-alanine dehydrogenase activity|NAD-linked alanine dehydrogenase activity|NADH-dependent alanine dehydrogenase activity|AlaDH|L-alanine dehydrogenase activity|NAD-dependent alanine dehydrogenase activity RHEA:18405|MetaCyc:ALANINE-DEHYDROGENASE-RXN|EC:1.4.1.1 molecular_function owl:Class
GO:0102774 biolink:NamedThing p-coumaroyltriacetic acid lactone synthase activity Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + 3 malonyl-CoA( <=> p-coumaroyltriacetic acid lactone + 4 coenzyme A + 3 carbon dioxide. got7fsn_ti MetaCyc:RXN-7822 molecular_function owl:Class
GO:0016269 biolink:NamedThing O-glycan processing, core 3 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc. got7fsn_ti biological_process owl:Class
GO:0047818 biolink:NamedThing D-fuconate dehydratase activity Catalysis of the reaction: D-fuconate = 2-dehydro-3-deoxy-D-fuconate + H(2)O. got7fsn_ti D-fuconate hydro-lyase activity|D-fuconate hydro-lyase (2-dehydro-3-deoxy-D-fuconate-forming)|D-fuconate hydratase activity MetaCyc:D-FUCONATE-HYDRATASE-RXN|RHEA:12949|EC:4.2.1.67|KEGG_REACTION:R03671 molecular_function owl:Class
GO:0099051 biolink:NamedThing vesicle scission involved in endocytosis The membrane scission process that is the final step in the formation of an endocytic vesicle: separation from the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0099050 biolink:NamedThing vesicle scission The membrane scission process that is the final step in the formation of a vesicle, leading to separation from its parent membrane. Vesicle scission involves the constriction of a neck-forming protein complex, consisting e.g. of dynamin, around the budded membrane, leading to vesicle closure during its separation from the parent membrane. got7fsn_ti biological_process owl:Class
GO:0036016 biolink:NamedThing cellular response to interleukin-3 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus. got7fsn_ti cellular response to IL-3 bf 2011-10-12T10:09:10Z biological_process owl:Class
GO:0036015 biolink:NamedThing response to interleukin-3 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus. got7fsn_ti response to IL-3 bf 2011-10-12T10:08:26Z biological_process owl:Class
GO:0051786 biolink:NamedThing all-trans-retinol 13,14-reductase activity Catalysis of the reaction: all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH(2). Note that this reaction has only been observed to occur in the opposite direction. got7fsn_ti RetSat activity|all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase activity|all-trans-retinol:all-trans-13,14-dihydroretinol saturase activity|(13,14)-all-trans-retinol saturase activity|retinol saturase activity MetaCyc:1.3.99.23-RXN|KEGG_REACTION:R07163|RHEA:19193|EC:1.3.99.23|Reactome:R-HSA-8956427 molecular_function owl:Class
GO:0030277 biolink:NamedThing maintenance of gastrointestinal epithelium Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents. got7fsn_ti biological_process owl:Class
GO:0042409 biolink:NamedThing caffeoyl-CoA O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA. got7fsn_ti S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase activity|caffeoyl coenzyme A methyltransferase activity|caffeoyl-CoA 3-O-methyltransferase activity|trans-caffeoyl-CoA 3-O-methyltransferase activity MetaCyc:CAFFEOYL-COA-O-METHYLTRANSFERASE-RXN|RHEA:16925|EC:2.1.1.104 molecular_function owl:Class
GO:0032898 biolink:NamedThing neurotrophin production The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. got7fsn_ti biological_process owl:Class
GO:0010199 biolink:NamedThing organ boundary specification between lateral organs and the meristem The process in which boundaries between lateral organs and the meristem is established and maintained. got7fsn_ti biological_process owl:Class
GO:0036368 biolink:NamedThing cone photoresponse recovery The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers. got7fsn_ti cone phototransduction termination|cone response recovery bf 2012-09-26T14:35:20Z biological_process owl:Class
GO:0050372 biolink:NamedThing ubiquitin-calmodulin ligase activity Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin. got7fsn_ti uCaM-synthetase activity|ubiquityl-calmodulin synthase activity|ubiquitin-calmodulin synthetase activity|ubiquityl-calmodulin synthetase activity|calmodulin:ubiquitin ligase (AMP-forming) MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN molecular_function owl:Class
GO:0031025 biolink:NamedThing equatorial microtubule organizing center disassembly The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis. got7fsn_ti equatorial microtubule organising center disassembly biological_process owl:Class
GO:0061592 biolink:NamedThing phosphatidylserine exposure on osteoblast involved in bone mineralization A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization. got7fsn_ti dph 2014-02-05T15:27:39Z biological_process owl:Class
GO:0002149 biolink:NamedThing hypochlorous acid biosynthetic process The chemical reactions and pathways resulting in the formation of hypochlorous acid. got7fsn_ti hypochlorite biosynthetic process|HClO biosynthetic process|hypochlorous acid biosynthesis|HOCl biosynthetic process Note that this reaction is catalyzed by myeloperoxidase in neutrophils. hjd 2009-10-13T10:32:35Z biological_process owl:Class
GO:0103016 biolink:NamedThing tRNA-specific 2-thiouridylase activity Catalysis of the reaction: ATP + H+ + a tRNA uridine34 + a [TusE sulfur carrier protein]-S-sulfanylcysteine = AMP + diphosphoric acid + a tRNA 2-thiouridine34 + a [TusE sulfur carrier protein]-L-cysteine. got7fsn_ti MetaCyc:RXN0-2023 molecular_function owl:Class
GO:0052716 biolink:NamedThing hydroquinone:oxygen oxidoreductase activity Catalysis of the reaction: 4 hydroquinone + O2 = 4 benzosemiquinone + 4 H2O. got7fsn_ti p-diphenol:oxygen oxidoreductase activity|laccase reaction|benzenediol:oxygen oxidoreductase activity ai 2011-08-11T03:18:19Z EC:1.10.3.2|RHEA:11276|MetaCyc:LACCASE-RXN|KEGG_REACTION:R00083 molecular_function owl:Class
GO:0008825 biolink:NamedThing cyclopropane-fatty-acyl-phospholipid synthase activity Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. got7fsn_ti cyclopropane fatty acid synthase activity|cyclopropane fatty acid synthetase activity|cyclopropane synthase activity|S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)|cyclopropane synthetase activity|unsaturated-phospholipid methyltransferase activity|CFA synthase activity EC:2.1.1.79|MetaCyc:2.1.1.79-RXN|RHEA:11988 molecular_function owl:Class
GO:0090274 biolink:NamedThing positive regulation of somatostatin secretion Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas. got7fsn_ti tb 2010-02-05T02:54:14Z biological_process owl:Class
GO:0021509 biolink:NamedThing roof plate formation The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells. got7fsn_ti biological_process owl:Class
GO:0034735 biolink:NamedThing transcription factor TFIIIC2 complex A transcription factor complex that forms part of the TFIIIC complex, observed in human; composed of five subunits (GTF3C1/hTFIIIC220/TFIIICalpha, GTF3C2/hTFIIIC110/TFIIICbeta, GTF3C3/hTFIIIC102/TFIIICgamma, GTF3C4/hTFIIIC90/TFIIICdelta and GTF3C5/hTFIIIC63/TFIIICepsilon in human) that together recognize the type 2 RNA polymerase III promoter. got7fsn_ti cellular_component owl:Class
GO:0031101 biolink:NamedThing fin regeneration The regrowth of fin tissue following its loss or destruction. got7fsn_ti biological_process owl:Class
GO:0047683 biolink:NamedThing aryl-aldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: an aromatic aldehyde + NADP+ + AMP + diphosphate + H2O = an aromatic acid + NADPH + ATP. got7fsn_ti aryl-aldehyde:NADP+ oxidoreductase (ATP-forming)|aromatic acid reductase activity RHEA:19229|MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-NADP+-RXN|EC:1.2.1.30 molecular_function owl:Class
GO:0071092 biolink:NamedThing alpha3-beta1 integrin-tissue transglutaminase complex A protein complex that consists of an alpha3-beta1 integrin complex bound to tissue transglutaminase. got7fsn_ti ITGA3-ITGB1-TGM2 complex mah 2009-11-06T04:47:04Z cellular_component owl:Class
GO:0052656 biolink:NamedThing L-isoleucine transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid. got7fsn_ti L-isoleucine aminotransferase activity KEGG_REACTION:R02199|EC:2.6.1.42|RHEA:24801|MetaCyc:BRANCHED-CHAINAMINOTRANSFERILEU-RXN molecular_function owl:Class
GO:0008214 biolink:NamedThing protein dealkylation The removal of an alkyl group from a protein amino acid. Alkyl groups are derived from alkanes by removal of one hydrogen atom. got7fsn_ti protein amino acid dealkylation biological_process owl:Class
GO:0010508 biolink:NamedThing positive regulation of autophagy Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. got7fsn_ti biological_process owl:Class
GO:0004145 biolink:NamedThing diamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine. got7fsn_ti spermidine N(1)-acetyltransferase activity|acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity|acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity|spermine N-acetyltransferase|putrescine acetyltransferase activity|spermidine N1-acetyltransferase activity|putrescine acetylase activity|spermidine acetyltransferase activity|spermidine/spermine N1-acetyltransferase activity|spermine acetyltransferase|spermine N(1)-acetyltransferase|putrescine (diamine)-acetylating enzyme activity|diamine acetyltransferase activity|putrescine N-acetyltransferase activity MetaCyc:DIAMACTRANS-RXN|EC:2.3.1.57|Reactome:R-HSA-351208|Reactome:R-HSA-351207|RHEA:25181 molecular_function owl:Class
GO:1900578 biolink:NamedThing gerfelin biosynthetic process The chemical reactions and pathways resulting in the formation of gerfelin. got7fsn_ti gerfelin biosynthesis|gerfelin anabolism|gerfelin formation|gerfelin synthesis di 2012-05-15T06:42:47Z biological_process owl:Class
GO:0050174 biolink:NamedThing phenylalanine decarboxylase activity Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2. got7fsn_ti L-phenylalanine carboxy-lyase (phenylethylamine-forming)|L-phenylalanine decarboxylase activity|aromatic L-amino acid decarboxylase activity|L-phenylalanine carboxy-lyase activity MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN|RHEA:19717|EC:4.1.1.53 molecular_function owl:Class
GO:0006287 biolink:NamedThing base-excision repair, gap-filling Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template. got7fsn_ti biological_process owl:Class
GO:0047765 biolink:NamedThing caldesmon-phosphatase activity Catalysis of the reaction: caldesmon phosphate + H2O = caldesmon + phosphate. got7fsn_ti SMP-I|caldesmon-phosphate phosphohydrolase activity|smooth muscle caldesmon phosphatase activity EC:3.1.3.55|MetaCyc:CALDESMON-PHOSPHATASE-RXN molecular_function owl:Class
GO:1990211 biolink:NamedThing positive regulation by symbiont of jasmonic acid levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-09T18:58:37Z biological_process owl:Class
GO:0047199 biolink:NamedThing phosphatidylcholine-dolichol O-acyltransferase activity Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + dolichol = 1-acyl-sn-glycero-3-phosphocholine + acyldolichol. got7fsn_ti 3-sn-phosphatidylcholine:dolichol O-acyltransferase activity MetaCyc:2.3.1.83-RXN|RHEA:19285|KEGG_REACTION:R04227|EC:2.3.1.83 molecular_function owl:Class
GO:0045900 biolink:NamedThing negative regulation of translational elongation Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation. got7fsn_ti downregulation of translational elongation|down regulation of translational elongation|inhibition of translational elongation|down-regulation of translational elongation biological_process owl:Class
GO:0097214 biolink:NamedThing positive regulation of lysosomal membrane permeability Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane. got7fsn_ti positive regulation of lysosome membrane permeability pr 2012-01-12T10:22:17Z biological_process owl:Class
GO:0009742 biolink:NamedThing brassinosteroid mediated signaling pathway A series of molecular signals mediated by the detection of brassinosteroid. got7fsn_ti brassinosteroid mediated signalling biological_process owl:Class
GO:0080043 biolink:NamedThing quercetin 3-O-glucosyltransferase activity Catalysis of the transfer of a glucosyl group from UDP-glucose to the 3-hydroxy group of a quercetin molecule. got7fsn_ti molecular_function owl:Class
GO:0047147 biolink:NamedThing trimethylsulfonium-tetrahydrofolate N-methyltransferase activity Catalysis of the reaction: (6S)-5,6,7,8-tetrahydrofolate + trimethylsulfonium = (6S)-5-methyl-5,6,7,8-tetrahydrofolate + dimethyl sulfide + H(+). got7fsn_ti trimethylsulfonium-tetrahydrofolate methyltransferase activity|trimethylsulfonium:tetrahydrofolate N-methyltransferase activity|trimethylsulphonium-tetrahydrofolate N-methyltransferase activity RHEA:13693|EC:2.1.1.19|MetaCyc:2.1.1.19-RXN|KEGG_REACTION:R02573 molecular_function owl:Class
GO:0051412 biolink:NamedThing response to corticosterone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses. got7fsn_ti response to corticosterone stimulus biological_process owl:Class
GO:0051385 biolink:NamedThing response to mineralocorticoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. got7fsn_ti response to mineralocorticoid stimulus biological_process owl:Class
GO:0071948 biolink:NamedThing activation-induced B cell apoptotic process B cell apoptotic process that occurs upon engagement of either the B cell receptor or CD40. Engagement of either receptor, but not both, leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death. got7fsn_ti activation-induced cell death of B lymphocytes|antigen-driven apoptosis|activation-induced cell death of B-lymphocytes|activation-induced cell death of B-cells|AICD|activation-induced cell death of B cells|activation-induced B cell apoptosis|activated B cell apoptosis|activation-induced B-cell apoptosis mah 2010-10-06T02:47:46Z biological_process owl:Class
GO:0050479 biolink:NamedThing glyceryl-ether monooxygenase activity Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine). got7fsn_ti glyceryl-ether cleaving enzyme activity|alkylglycerol monooxygenase activity|glyceryl etherase activity|O-alkylglycerol monooxygenase activity|glyceryl ether oxygenase activity|1-alkyl-sn-glycerol,tetrahydrobiopterin:oxygen oxidoreductase activity EC:1.14.16.5|RHEA:36255|MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN|Reactome:R-HSA-5696119 molecular_function owl:Class
GO:0043664 biolink:NamedThing host peribacteroid membrane A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells). got7fsn_ti cellular_component owl:Class
GO:0015919 biolink:NamedThing peroxisomal membrane transport The directed movement of substances to, from or across the peroxisomal membrane. got7fsn_ti biological_process owl:Class
GO:0043574 biolink:NamedThing peroxisomal transport Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. got7fsn_ti biological_process owl:Class
GO:0004735 biolink:NamedThing pyrroline-5-carboxylate reductase activity Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. got7fsn_ti L-proline oxidase activity|NADPH-L-delta1-pyrroline carboxylic acid reductase activity|P5CR activity|L-proline:NAD(P)+ 5-oxidoreductase activity|L-proline-NAD(P)+ 5-oxidoreductase activity|1-pyrroline-5-carboxylate reductase activity EC:1.5.1.2|Reactome:R-HSA-6783955|RHEA:14109|MetaCyc:PYRROLINECARBREDUCT-RXN|Reactome:R-HSA-70664|Reactome:R-HSA-6783939 molecular_function owl:Class
GO:0070181 biolink:NamedThing small ribosomal subunit rRNA binding Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. got7fsn_ti SSU rRNA binding|18S rRNA binding molecular_function owl:Class
GO:0033832 biolink:NamedThing alpha,alpha-trehalose phosphorylase (configuration-retaining) activity Catalysis of the reaction: alpha,alpha-trehalose + phosphate = alpha-D-glucose + alpha-D-glucose 1-phosphate. got7fsn_ti alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase activity|trehalose phosphorylase activity MetaCyc:RXN-4441|RHEA:16257 molecular_function owl:Class
GO:0043805 biolink:NamedThing indolepyruvate ferredoxin oxidoreductase activity Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin. got7fsn_ti IOR|indolepyruvate oxidoreductase activity|3-(indol-3-yl)pyruvate:ferredoxin oxidoreductase (decarboxylating, CoA-indole-acetylating)|3-(indol-3-yl)pyruvate synthase (ferredoxin) activity EC:1.2.7.8|MetaCyc:1.2.7.8-RXN|RHEA:12645 molecular_function owl:Class
GO:0102333 biolink:NamedThing stearoyl-[acp] elongase/decarboxylase activity Catalysis of the reaction: malonyl-CoA + 3 H+ + a stearoyl-[acp] = nonadec-1-ene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-13261 molecular_function owl:Class
GO:0046745 biolink:NamedThing viral capsid secondary envelopment The process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope. got7fsn_ti Golgi membrane viral budding during viral capsid re-envelopment|virus budding from inner nuclear membrane by viral capsid re-envelopment|virus budding from Golgi membrane by viral capsid re-envelopment|virus budding from nuclear membrane during viral capsid re-envelopment|viral capsid re-envelopment|endoplasmic reticulum membrane viral budding during viral capsid re-envelopment|viral budding from nuclear membrane during viral capsid re-envelopment|viral budding from inner nuclear membrane by viral capsid re-envelopment|virus budding from ER membrane during viral capsid re-envelopment|viral budding from Golgi membrane by viral capsid re-envelopment|ER membrane viral budding during viral capsid re-envelopment|viral budding from Golgi membrane during viral capsid re-envelopment|nuclear membrane viral budding during viral capsid re-envelopment|virus budding from outer nuclear membrane during viral capsid re-envelopment|virus budding from nuclear membrane by viral capsid re-envelopment|viral budding from plasma membrane by viral capsid re-envelopment|virus budding from Golgi membrane during viral capsid re-envelopment|viral budding from nuclear membrane by viral capsid re-envelopment|virus budding from plasma membrane during viral capsid re-envelopment|virus budding from ER membrane by viral capsid re-envelopment|viral budding from inner nuclear membrane during viral capsid re-envelopment|virus budding from inner nuclear membrane during viral capsid re-envelopment|viral budding from plasma membrane during viral capsid re-envelopment|virus budding from outer nuclear membrane by viral capsid re-envelopment|viral budding from ER membrane by viral capsid re-envelopment|inner nuclear membrane viral budding during viral capsid re-envelopment|viral budding from outer nuclear membrane by viral capsid re-envelopment|viral budding from ER membrane during viral capsid re-envelopment|viral budding from outer nuclear membrane during viral capsid re-envelopment|plasma membrane viral budding during viral capsid re-envelopment|outer nuclear membrane viral budding during viral capsid re-envelopment GO:0046770|GO:0046747|GO:0046769|GO:0046768|GO:0046746|GO:0046748 biological_process owl:Class
GO:0102183 biolink:NamedThing avenastenone reductase activity Catalysis of the reaction: avenastenone + NADPH + H+ <=> avenasterol + NADP. got7fsn_ti MetaCyc:RXN-11939 molecular_function owl:Class
GO:0042406 biolink:NamedThing extrinsic component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to ER membrane|extrinsic to endoplasmic reticulum membrane cellular_component owl:Class
GO:0048485 biolink:NamedThing sympathetic nervous system development The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. got7fsn_ti biological_process owl:Class
GO:0033723 biolink:NamedThing fluoroacetaldehyde dehydrogenase activity Catalysis of the reaction: fluoroacetaldehyde + NAD+ + H2O = fluoroacetate + NADH + 2 H+. got7fsn_ti fluoroacetaldehyde:NAD+ oxidoreductase activity EC:1.2.1.69|RHEA:16677 molecular_function owl:Class
GO:0102502 biolink:NamedThing ADP-glucose-starch glucosyltransferase activity Catalysis of the reaction: ADP alpha-D-glucoside + n a 1,4-alpha-D-glucan = ADP + n alpha-amylose. got7fsn_ti EC:2.4.1.242|MetaCyc:RXN-14378 molecular_function owl:Class
GO:0050674 biolink:NamedThing urothelial cell proliferation The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria. got7fsn_ti biological_process owl:Class
GO:0031089 biolink:NamedThing platelet dense granule lumen The volume enclosed by the membrane of the platelet dense granule. got7fsn_ti cellular_component owl:Class
GO:0050121 biolink:NamedThing N-acylglucosamine 2-epimerase activity Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine. got7fsn_ti N-acyl-D-glucosamine 2-epimerase activity|GlcNAc 2-epimerase activity|acylglucosamine 2-epimerase activity|N-acetyl-D-glucosamine 2-epimerase activity|N-acetylglucosamine 2-epimerase activity EC:5.1.3.8|Reactome:R-HSA-6803761|RHEA:19033|MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN molecular_function owl:Class
GO:1900590 biolink:NamedThing violaceol I biosynthetic process The chemical reactions and pathways resulting in the formation of violaceol I. got7fsn_ti violaceol I formation|violaceol I synthesis|violaceol I biosynthesis|violaceol I anabolism di 2012-05-15T06:51:16Z biological_process owl:Class
GO:0050622 biolink:NamedThing glycine dehydrogenase (cyanide-forming) activity Catalysis of the reaction: glycine + 2 A = HCN + CO2 + 2 AH2. got7fsn_ti glycine:acceptor oxidoreductase (hydrogen-cyanide-forming)|HCN synthase activity|hydrogen cyanide synthase activity MetaCyc:1.4.99.5-RXN|RHEA:15821|EC:1.4.99.5 molecular_function owl:Class
GO:0043528 biolink:NamedThing tRNA (m2G10) methyltransferase complex A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p. got7fsn_ti cellular_component owl:Class
GO:0070876 biolink:NamedThing SOSS complex A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. got7fsn_ti mah 2009-08-20T03:30:48Z cellular_component owl:Class
GO:0031755 biolink:NamedThing Edg-2 lysophosphatidic acid receptor binding Binding to an Edg-2 lysophosphatidic acid receptor. got7fsn_ti Edg-2 lysophosphatidic acid receptor ligand|LPA1 receptor binding molecular_function owl:Class
GO:0033452 biolink:NamedThing GUG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GUG codon. got7fsn_ti valine tRNA|GTG codon-amino acid adaptor activity Note that in the standard genetic code, GTG codes for valine. molecular_function owl:Class
GO:0047284 biolink:NamedThing dolichyl-xylosyl-phosphate-protein xylosyltransferase activity Catalysis of the reaction: dolichyl D-xylosyl phosphate + protein = dolichol-phosphate + D-xylosylprotein. got7fsn_ti dolichyl-D-xylosyl-phosphate:protein D-xylosyltransferase activity EC:2.4.2.33|MetaCyc:2.4.2.33-RXN|RHEA:18361 molecular_function owl:Class
GO:0042152 biolink:NamedThing RNA-mediated DNA recombination The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele. got7fsn_ti biological_process owl:Class
GO:0008996 biolink:NamedThing ribonuclease G activity Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group. got7fsn_ti molecular_function owl:Class
GO:0047619 biolink:NamedThing acylcarnitine hydrolase activity Catalysis of the reaction: O-acylcarnitine + H2O = a fatty acid + L-carnitine. got7fsn_ti carnitine ester hydrolase activity|palmitoyl carnitine hydrolase activity|O-acylcarnitine acylhydrolase activity|high activity acylcarnitine hydrolase activity|palmitoyl-L-carnitine hydrolase activity|long-chain acyl-L-carnitine hydrolase activity|palmitoylcarnitine hydrolase activity|HACH RHEA:17101|MetaCyc:ACYLCARNITINE-HYDROLASE-RXN|EC:3.1.1.28 molecular_function owl:Class
GO:0097133 biolink:NamedThing cyclin D3-CDK6 complex A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:57:41Z cellular_component owl:Class
GO:0035455 biolink:NamedThing response to interferon-alpha Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon. got7fsn_ti response to interferon alfa-n1|response to leukocyte interferon|response to lymphoblast interferon|response to interferon alfa-n3|response to lymphoblastoid interferon bf 2010-04-16T10:57:16Z biological_process owl:Class
GO:0000933 biolink:NamedThing adventitious septum A cell septum whose formation is independent of nuclear division. got7fsn_ti cellular_component owl:Class
GO:0047091 biolink:NamedThing L-lysine 6-monooxygenase (NADPH) activity Catalysis of the reaction: L-lysine + NADPH + O(2) = N(6)-hydroxy-L-lysine + H(2)O + NADP(+). got7fsn_ti L-lysine,NADPH:oxygen oxidoreductase (6-hydroxylating)|L-lysine 6-monooxygenase activity|lysine N(6)-hydroxylase activity|lysine N6-hydroxylase activity Note that EC:1.13.12.10 was merged into this term. GO:0008739 KEGG_REACTION:R00448|RHEA:23228|EC:1.14.13.59|MetaCyc:1.14.13.59-RXN molecular_function owl:Class
GO:0018134 biolink:NamedThing peptide cross-linking via glycine oxazolecarboxylic acid The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation. got7fsn_ti RESID:AA0240 biological_process owl:Class
GO:0018713 biolink:NamedThing 3-ketopimelyl-CoA thiolase activity Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA. got7fsn_ti UM-BBD_reactionID:r0197|MetaCyc:RXN-8032 molecular_function owl:Class
GO:1904949 biolink:NamedThing ATPase complex A protein complex which is capable of ATPase activity. got7fsn_ti VPS4 complex An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay). bhm 2016-02-04T22:13:32Z cellular_component owl:Class
GO:0102562 biolink:NamedThing hydroxyproline O-arbinofuranose transferase activity Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline = UDP + H+ + a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline. got7fsn_ti MetaCyc:RXN-15011|RHEA:49472 molecular_function owl:Class
GO:0030290 biolink:NamedThing sphingolipid activator protein activity Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase. got7fsn_ti saposin Reactome:R-HSA-1605717 molecular_function owl:Class
GO:0003130 biolink:NamedThing BMP signaling pathway involved in heart induction A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction. got7fsn_ti BMP signalling pathway involved in heart induction tb 2009-09-22T03:02:00Z biological_process owl:Class
GO:0033977 biolink:NamedThing 2-haloacid dehalogenase (configuration-retaining) activity Catalysis of the reactions: (S)-2-haloacid + H2O = (S)-2-hydroxyacid + halide, and (R)-2-haloacid + H2O = (R)-2-hydroxyacid + halide. got7fsn_ti DL-DEXr|2-haloalkanoid acid halidohydrolase activity|2-haloalkanoic acid dehalogenase activity|DL-2-haloacid dehalogenase activity EC:3.8.1.11|MetaCyc:3.8.1.11-RXN|RHEA:12072 molecular_function owl:Class
GO:0045920 biolink:NamedThing negative regulation of exocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis. got7fsn_ti down-regulation of exocytosis|inhibition of exocytosis|down regulation of exocytosis|downregulation of exocytosis biological_process owl:Class
GO:0070524 biolink:NamedThing 11-beta-hydroxysteroid dehydrogenase (NADP+) activity Catalysis of the reaction: an 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+. got7fsn_ti beta-hydroxysteroid dehydrogenase|corticosteroid 11-beta-dehydrogenase activity EC:1.1.1.146|Wikipedia:11beta-hydroxysteroid_dehydrogenase|RHEA:11388|MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0033015 biolink:NamedThing tetrapyrrole catabolic process The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. got7fsn_ti tetrapyrrole breakdown|tetrapyrrole catabolism|tetrapyrrole degradation biological_process owl:Class
GO:0098886 biolink:NamedThing modification of dendritic spine Any process that modifies the structure of a dendritic spine. got7fsn_ti This class does not cover assembly or disassembly of dendritic spines, only the modification/remodelling of existing ones. biological_process owl:Class
GO:0071954 biolink:NamedThing chemokine (C-C motif) ligand 11 production The appearance of chemokine (C-C motif) ligand 11 (CCL11, also known as eotaxin-1) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti CCL11 production|eotaxin-1 production|eotaxin production|C-C motif chemokine 11 production|CCL-11 production mah 2010-10-08T12:10:34Z biological_process owl:Class
GO:1990465 biolink:NamedThing aldehyde oxygenase (deformylating) activity Catalysis of the reaction a long-chain aldehyde + O(2) + 2 NADPH = an alkane + formate + H(2)O + 2 NADP(+). got7fsn_ti tt 2014-08-25T15:16:43Z RHEA:21440|EC:4.1.99.5 molecular_function owl:Class
GO:0102963 biolink:NamedThing (S)-corytuberine synthase activity Catalysis of the reaction: H+ + (S)-reticulinium(1+) + NADPH + O2 <=> (S)-corytuberine + NADP + 2 H2O. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21133 RHEA:51540|MetaCyc:RXN-9314|EC:1.14.19.51 molecular_function owl:Class
GO:1901097 biolink:NamedThing negative regulation of autophagosome maturation Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome maturation. got7fsn_ti negative regulation of amphisome-lysosome fusion|down-regulation of autophagic vacuole maturation|negative regulation of autophagic vacuole fusion|down-regulation of autophagic vacuole fusion|inhibition of fusion of autophagosome with lysosome|inhibition of amphisome-lysosome fusion|inhibition of autophagic vacuole fusion|downregulation of autophagic vacuole fusion|negative regulation of autophagosome maturation|downregulation of autolysosome formation|downregulation of autophagic vacuole maturation|negative regulation of autolysosome formation|down-regulation of autophagosome maturation|downregulation of amphisome-lysosome fusion|inhibition of autolysosome formation|down-regulation of fusion of autophagosome with lysosome|negative regulation of autophagosome fusion|down regulation of amphisome-lysosome fusion|down regulation of autophagic vacuole fusion|negative regulation of fusion of autophagosome with lysosome|inhibition of autophagic vacuole maturation|inhibition of autophagosome maturation|down regulation of autophagic vacuole maturation|down regulation of fusion of autophagosome with lysosome|down-regulation of autolysosome formation|downregulation of autophagosome maturation|downregulation of fusion of autophagosome with lysosome|down regulation of autophagosome maturation|down-regulation of amphisome-lysosome fusion|down regulation of autolysosome formation lb 2012-07-10T07:22:26Z GO:1902453 biological_process owl:Class
GO:0016242 biolink:NamedThing negative regulation of macroautophagy Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy. got7fsn_ti inhibition of macroautophagy|negative regulation of starvation-induced autophagy|downregulation of macroautophagy|down regulation of macroautophagy|down-regulation of macroautophagy biological_process owl:Class
GO:0010290 biolink:NamedThing chlorophyll catabolite transmembrane transporter activity Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0014706 biolink:NamedThing striated muscle tissue development The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells. got7fsn_ti biological_process owl:Class
GO:0018112 biolink:NamedThing proline racemase activity Catalysis of the reaction: L-proline = D-proline. got7fsn_ti KEGG_REACTION:R01255|RHEA:10680|EC:5.1.1.4|MetaCyc:PROLINE-RACEMASE-RXN molecular_function owl:Class
GO:0008532 biolink:NamedThing N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. got7fsn_ti uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase|uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase|UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity|galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity|UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity|GnTE activity|UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity|N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity|poly-N-acetyllactosamine extension enzyme activity RHEA:14389|MetaCyc:2.4.1.149-RXN|EC:2.4.1.149|Reactome:R-HSA-2025724 molecular_function owl:Class
GO:0050053 biolink:NamedThing levansucrase activity Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1). got7fsn_ti sucrose 6-fructosyl transferase activity|beta-2,6-fructan:D-glucose 1-fructosyltransferase activity|sucrose:2,6-beta-D-fructan 6-beta-D-fructosyltransferase activity|sucrose 6-fructosyltransferase activity|beta-2,6-fructosyltransferase activity EC:2.4.1.10|MetaCyc:LEVANSUCRASE-RXN|RHEA:13653 molecular_function owl:Class
GO:0018601 biolink:NamedThing 4-nitrophenol 2-monooxygenase activity Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+). got7fsn_ti 4-nitrophenol hydroxylase activity|4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)|4-nitrophenol-2-hydroxylase activity RHEA:12568|EC:1.14.13.29|KEGG_REACTION:R03023|UM-BBD_reactionID:r0230|MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0018651 biolink:NamedThing toluene-4-sulfonate monooxygenase activity Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene. got7fsn_ti toluene-4-sulphonate monooxygenase activity UM-BBD_reactionID:r0296|EC:1.14.13.- molecular_function owl:Class
GO:0043328 biolink:NamedThing protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway The process of directing proteins towards the vacuole that contributes to protein catabolism via the multivesicular body (MVB) pathway. got7fsn_ti protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway|protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway|protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway|protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway|protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway|protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway|protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway|protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway|protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway biological_process owl:Class
GO:0003854 biolink:NamedThing 3-beta-hydroxy-delta5-steroid dehydrogenase activity Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+). got7fsn_ti 3beta-hydroxy steroid dehydrogenase/isomerase activity|3-beta-hydroxy-D5-steroid dehydrogenase activity|3beta-hydroxy-delta5-C27-steroid oxidoreductase|delta5-3beta-hydroxysteroid dehydrogenase activity|3beta-hydroxy-5-ene-steroid dehydrogenase activity|progesterone reductase activity|3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity|3beta-HSDH|steroid-delta5-3beta-ol dehydrogenase activity|3beta-hydroxy-delta5-steroid dehydrogenase activity|3beta-hydroxy-5-ene steroid dehydrogenase activity|3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity|3beta-hydroxy-5-ene-steroid oxidoreductase activity|3-beta-hydroxy-5-ene steroid dehydrogenase activity|5-ene-3-beta-hydroxysteroid dehydrogenase activity MetaCyc:1.1.1.145-RXN|Reactome:R-HSA-192097|Reactome:R-HSA-196372|Reactome:R-HSA-193789|Reactome:R-HSA-196350|RHEA:24076|EC:1.1.1.145|Reactome:R-HSA-193816 molecular_function owl:Class
GO:0071532 biolink:NamedThing ankyrin repeat binding Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure. got7fsn_ti ANK repeat binding mah 2010-01-08T02:21:02Z molecular_function owl:Class
GO:0008447 biolink:NamedThing L-ascorbate oxidase activity Catalysis of the reaction: 4 L-ascorbate + O(2) <=> 4 monodehydroascorbate + 2 H(2)O. got7fsn_ti ascorbase activity|ascorbate oxidase activity|AAO|ascorbate dehydrogenase activity|L-ascorbate:O2 oxidoreductase activity|ascorbic oxidase activity|L-ascorbic acid oxidase activity|AA oxidase activity|ascorbic acid oxidase activity|L-ascorbate:oxygen oxidoreductase activity https://github.com/geneontology/go-ontology/issues/21022 EC:1.10.3.3|RHEA:30243|MetaCyc:L-ASCORBATE-OXIDASE-RXN molecular_function owl:Class
GO:0035357 biolink:NamedThing peroxisome proliferator activated receptor signaling pathway The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes. got7fsn_ti peroxisome proliferator activated receptor signalling pathway|PPAR signaling pathway|peroxisome proliferator-activated receptor signaling pathway bf 2010-03-05T10:30:10Z biological_process owl:Class
GO:0035614 biolink:NamedThing snRNA stem-loop binding Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. got7fsn_ti snRNA hairpin loop binding|small nuclear RNA stem-loop binding|snRNA hairpin binding bf 2010-11-26T10:43:17Z molecular_function owl:Class
GO:0042725 biolink:NamedThing thiamine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it. got7fsn_ti thiamine-containing compound degradation|vitamin B1 and derivative catabolic process|thiamin-containing compound catabolic process|thiamin and derivative catabolic process|thiamine-containing compound breakdown|thiamine and derivative catabolic process|thiamine and derivative catabolism|thiamine-containing compound catabolism|vitamin B1 and derivative catabolism|thiamin and derivative catabolism biological_process owl:Class
GO:0097710 biolink:NamedThing viral terminase, small subunit The part of the viral terminase complex that acts as a phage DNA-recognition component and regulates the activity of the large subunit. The small subunit usually assembles as a heterooligomer with the large subunit. got7fsn_ti virus terminase, small subunit This term should only be used when the small subunit consists of more than one polypeptide. pr 2016-06-07T12:45:00Z cellular_component owl:Class
GO:0070196 biolink:NamedThing eukaryotic translation initiation factor 3 complex assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 3 complex. got7fsn_ti eIF-3 assembly|eIF3 assembly biological_process owl:Class
GO:0045818 biolink:NamedThing negative regulation of glycogen catabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen. got7fsn_ti downregulation of glycogen catabolic process|negative regulation of glycogen catabolism|negative regulation of glycogenolysis|negative regulation of glycogen degradation|inhibition of glycogen catabolic process|down-regulation of glycogen catabolic process|down regulation of glycogen catabolic process|negative regulation of glycogen breakdown biological_process owl:Class
GO:0016985 biolink:NamedThing mannan endo-1,4-beta-mannosidase activity Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans. got7fsn_ti endo-beta-mannanase activity|endo-1,4-mannanase activity|beta-mannanase activity|endo-beta-1,4-mannase activity|1,4-beta-D-mannan mannanohydrolase activity|beta-D-mannanase activity|beta-mannanase B|beta-1,4-mannan 4-mannanohydrolase activity|endo-1,4-beta-mannanase activity MetaCyc:3.2.1.78-RXN|EC:3.2.1.78 molecular_function owl:Class
GO:0003270 biolink:NamedThing Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti Notch signaling pathway involved in regulation of second heart field cardioblast proliferation|Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation dph 2009-10-15T02:47:00Z biological_process owl:Class
GO:0061314 biolink:NamedThing Notch signaling involved in heart development The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the progression of the heart over time. got7fsn_ti Notch signalling involved in heart development dph 2010-09-24T08:25:22Z biological_process owl:Class
GO:0010611 biolink:NamedThing regulation of cardiac muscle hypertrophy Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. got7fsn_ti biological_process owl:Class
GO:0061153 biolink:NamedThing trachea gland development The progression of a trachea gland over time, from its formation to the mature structure. Trachea glands are found under the mucus of the trachea and secrete mucus, and agents that help protect the lung from injury and infection. got7fsn_ti dph 2010-06-07T10:10:51Z biological_process owl:Class
GO:0103118 biolink:NamedThing UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity Catalysis of the reaction: UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine(1-) + an (3R)-3-hydroxymyristoyl-[acp] <=> UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + H+ + a holo-[acyl-carrier protein]. got7fsn_ti UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity GO:0043764 RHEA:17817|MetaCyc:UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN|EC:2.3.1.191 molecular_function owl:Class
GO:0016117 biolink:NamedThing carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. got7fsn_ti carotenoid formation|carotenoid biosynthesis|carotenoid anabolism|carotenoid synthesis MetaCyc:CAROTENOID-PWY biological_process owl:Class
GO:0017061 biolink:NamedThing S-methyl-5-thioadenosine phosphorylase activity Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate. got7fsn_ti MeSAdo/Ado phosphorylase activity|MeSAdo phosphorylase activity|5'-methylthioadenosine phosphorylase activity|5'-deoxy-5'-methylthioadenosine phosphorylase activity|methylthioadenosine phosphorylase activity|MTAPase activity|MTA phosphorylase activity|methylthioadenosine nucleoside phosphorylase activity|5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity|S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity Reactome:R-HSA-1237160|EC:2.4.2.28|MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN|RHEA:11852 molecular_function owl:Class
GO:0006423 biolink:NamedThing cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0047334 biolink:NamedThing diphosphate-fructose-6-phosphate 1-phosphotransferase activity Catalysis of the reaction: fructose-6-phosphate + diphosphate = phosphate + fructose-1,6-bisphosphate. got7fsn_ti pyrophosphate-dependent 6-phosphofructose-1-kinase activity|diphosphate:D-fructose-6-phosphate 1-phosphotransferase activity|6-phosphofructokinase (diphosphate) activity|diphosphate-dependent 6-phosphofructose-1-kinase activity|pyrophosphate-fructose 6-phosphate phosphotransferase activity|pyrophosphate-dependent phosphofructo-1-kinase activity|inorganic pyrophosphate-dependent phosphofructokinase activity|6-phosphofructokinase (pyrophosphate) activity|pyrophosphate--fructose 6-phosphate 1-phosphotransferase activity|inorganic pyrophosphate-phosphofructokinase activity MetaCyc:2.7.1.90-RXN|RHEA:13613|EC:2.7.1.90 molecular_function owl:Class
GO:0102049 biolink:NamedThing indole-3-acetyl-methionine synthetase activity Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) <=> H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10431 molecular_function owl:Class
GO:0102454 biolink:NamedThing cyanidin 3-O-galactosyltransferase activity Catalysis of the reaction: cyanidin + UDP-D-galactose = cyanidin 3-O-beta-D-galactoside betaine + UDP. got7fsn_ti EC:2.4.1.294|RHEA:35631|MetaCyc:RXN-13960 molecular_function owl:Class
GO:0034283 biolink:NamedThing syn-stemod-13(17)-ene synthase activity Catalysis of the reaction: 9-alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate. got7fsn_ti exo-stemodene synthase activity|syn-stemodene synthase activity|stemod-13(17)-ene synthase activity|stemodene synthase activity|9alpha-copalyl-diphosphate diphosphate-lyase [stemod-13(17)-ene-forming] activity RHEA:25556|KEGG_REACTION:R09116|MetaCyc:RXN-9291|EC:4.2.3.34 molecular_function owl:Class
GO:2000140 biolink:NamedThing negative regulation of octopamine signaling pathway involved in response to food Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food. got7fsn_ti negative regulation of octopamine signalling pathway involved in response to food mah 2010-09-30T02:48:10Z biological_process owl:Class
GO:0032096 biolink:NamedThing negative regulation of response to food Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus. got7fsn_ti inhibition of response to food|down regulation of response to food|down-regulation of response to food|downregulation of response to food biological_process owl:Class
GO:0015576 biolink:NamedThing sorbitol transmembrane transporter activity Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. got7fsn_ti glucitol permease activity|glucitol transporter activity|sorbitol permease activity GO:0015587 molecular_function owl:Class
GO:0016629 biolink:NamedThing 12-oxophytodienoate reductase activity Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + H(+) + NADPH. got7fsn_ti 12-oxo-phytodienoic acid reductase activity|8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity|12-oxo-phytodienoate reductase activity EC:1.3.1.42|RHEA:21888|MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN|KEGG_REACTION:R03401 molecular_function owl:Class
GO:0050518 biolink:NamedThing 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate. got7fsn_ti MCT activity|4-diphosphocytidyl-2C-methyl-D-erythritol synthase activity|CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity|4-diphosphocytidyl-2-C-methyl-D-erythritol synthase activity|MEP cytidylyltransferase activity GO:0008699 EC:2.7.7.60|KEGG_REACTION:R05633|RHEA:13429|MetaCyc:2.7.7.60-RXN molecular_function owl:Class
GO:0034006 biolink:NamedThing amorpha-4,11-diene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate. got7fsn_ti amorphadiene synthase activity|2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity MetaCyc:4.2.3.24-RXN|EC:4.2.3.24|RHEA:18325|KEGG_REACTION:R07630|MetaCyc:RXN-8046 molecular_function owl:Class
GO:0004654 biolink:NamedThing polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate. got7fsn_ti polyribonucleotide:phosphate nucleotidyltransferase activity|polyribonucleotide phosphorylase activity|polynucleotide phosphorylase activity|nucleoside diphosphate:polynucleotidyl transferase activity RHEA:22096|MetaCyc:2.7.7.8-RXN|EC:2.7.7.8 molecular_function owl:Class
GO:0017064 biolink:NamedThing fatty acid amide hydrolase activity Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid. got7fsn_ti GO:0017073 Reactome:R-HSA-5693742|Reactome:R-HSA-5693751 molecular_function owl:Class
GO:0042299 biolink:NamedThing lupeol synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol. got7fsn_ti oxidosqualene:lupeol cyclase activity EC:5.4.99.41|MetaCyc:RXN-111|RHEA:31383 molecular_function owl:Class
GO:0090036 biolink:NamedThing regulation of protein kinase C signaling Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. got7fsn_ti regulation of protein kinase C signalling cascade|regulation of protein kinase C signaling cascade tb 2009-08-03T11:27:26Z biological_process owl:Class
GO:0003359 biolink:NamedThing noradrenergic neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron. got7fsn_ti norepinephrine secreting neuron fate commitment dph 2009-12-03T10:41:08Z biological_process owl:Class
GO:0060269 biolink:NamedThing centripetally migrating follicle cell migration The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte. got7fsn_ti biological_process owl:Class
GO:0097259 biolink:NamedThing 20-aldehyde-leukotriene B4 20-monooxygenase activity Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase]. got7fsn_ti pr 2012-03-07T03:40:05Z Reactome:R-HSA-2161979|RHEA:48672|Reactome:R-HSA-2161792 molecular_function owl:Class
GO:0047629 biolink:NamedThing ADP deaminase activity Catalysis of the reaction: ADP + H2O = IDP + NH3. got7fsn_ti adenosine diphosphate deaminase activity|adenosinepyrophosphate deaminase activity|ADP aminohydrolase activity MetaCyc:ADP-DEAMINASE-RXN|EC:3.5.4.7|RHEA:12741 molecular_function owl:Class
GO:0061455 biolink:NamedThing integral component of muscle cell projection membrane The component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to muscle cell projection membrane dph 2012-07-27T02:38:01Z cellular_component owl:Class
GO:0071545 biolink:NamedThing inositol phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. got7fsn_ti inositol phosphate breakdown|inositol phosphate catabolism|inositol phosphate degradation|myo-inositol phosphate catabolic process See also the biological process term 'inositol phosphate dephosphorylation ; GO:0046855'. mah 2010-01-12T05:07:45Z biological_process owl:Class
GO:0015451 biolink:NamedThing decarboxylation-driven active transmembrane transporter activity Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. got7fsn_ti decarboxylation-driven transporter EC:7.2.4.1|TC:3.B|EC:7.2.4.2|EC:7.2.4.3|EC:7.2.4.5|EC:7.2.4.4 molecular_function owl:Class
GO:0021581 biolink:NamedThing medulla oblongata structural organization The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate. got7fsn_ti medulla structural maturation|medulla oblongata structural organisation|myelencephalon structural maturation biological_process owl:Class
GO:0085015 biolink:NamedThing dormancy maintenance of symbiont in host Any process in which a dormant state is maintained by the symbiont within the host organism. got7fsn_ti non-replicating persistence|NRP jl 2010-05-19T03:17:32Z biological_process owl:Class
GO:0008672 biolink:NamedThing 2-dehydro-3-deoxyglucarate aldolase activity Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde. got7fsn_ti 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)|2-keto-3-deoxyglucarate aldolase activity|alpha-keto-beta-deoxy-D-glucarate aldolase activity|2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity EC:4.1.2.20|RHEA:10268|MetaCyc:KDGALDOL-RXN molecular_function owl:Class
GO:0102623 biolink:NamedThing scutellarein 7-methyl ether 6-O-methyltransferase activity Catalysis of the reaction: scutellarein 7-methyl ether + S-adenosyl-L-methionine <=> cirsimaritin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-15528 molecular_function owl:Class
GO:0039624 biolink:NamedThing viral outer capsid The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions. got7fsn_ti outer capsid bf 2012-07-18T04:03:16Z cellular_component owl:Class
GO:0045957 biolink:NamedThing negative regulation of complement activation, alternative pathway Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway. got7fsn_ti down-regulation of complement activation, alternative pathway|downregulation of complement activation, alternative pathway|inhibition of complement activation, alternative pathway|negative regulation of complement cascade, alternative pathway|down regulation of complement activation, alternative pathway biological_process owl:Class
GO:0140625 biolink:NamedThing opioid growth factor receptor activity Combining with the opioid growth factor (OGF, met-enkephalin) and transmitting the signal across the nuclear membrane. Met-enkephalin is an endogenous opioid peptide that binds to opioid and opioid growth factor receptors, regulating tissue growth in a variety of cellular processes. got7fsn_ti methionine enkephalin receptor activity|met-enkephalin receptor activity|metenkefalin receptor activity https://github.com/geneontology/go-ontology/issues/21110 pg 2021-03-17T13:15:33Z molecular_function owl:Class
GO:0140240 biolink:NamedThing perforant pathway to dendrate granule cell synapse A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus. got7fsn_ti perforant pathway to DG granule cell synapse https://github.com/geneontology/synapse/issues/234 pg 2018-07-15T08:21:43Z cellular_component owl:Class
GO:0090640 biolink:NamedThing phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine. got7fsn_ti tb 2015-04-23T15:56:12Z biological_process owl:Class
GO:0000825 biolink:NamedThing inositol tetrakisphosphate 6-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. got7fsn_ti inositol 1,3,4,5-tetrakisphosphate 6-kinase activity|1D-myo-inositol-tetrakisphosphate 6-kinase activity MetaCyc:RXN-7184|Reactome:R-HSA-1855206 molecular_function owl:Class
GO:0050112 biolink:NamedThing inositol 2-dehydrogenase activity Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH. got7fsn_ti inositol:NAD 2-dehydrogenase activity|myo-inositol 2-dehydrogenase activity EC:1.1.1.18|MetaCyc:MYO-INOSITOL-2-DEHYDROGENASE-RXN|KEGG_REACTION:R01183|RHEA:16949 molecular_function owl:Class
GO:0075267 biolink:NamedThing aecium development The process in which a cup-like structure containing chains of aeciospores is formed. This is characteristic of the rust fungus and typically, the first dikaryotic spores (aeciospores) are produced in the aecium. got7fsn_ti biological_process owl:Class
GO:0034023 biolink:NamedThing 5-(carboxyamino)imidazole ribonucleotide mutase activity Catalysis of the reaction: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate. got7fsn_ti PurE|N5-CAIR mutase activity|class I PurE|5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole carboxymutase activity|N5-carboxyaminoimidazole ribonucleotide mutase activity EC:5.4.99.18|RHEA:13193|MetaCyc:5.4.99.18-RXN molecular_function owl:Class
GO:0046891 biolink:NamedThing peptidyl-cysteine S-carbamoylation The carbamoylation of peptidyl-cysteine to form peptidyl-S-carbamoyl-L-cysteine. got7fsn_ti RESID:AA0332 biological_process owl:Class
GO:0080069 biolink:NamedThing 7-methylthioheptyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 7-methylthioheptyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = 7-methylthioheptyl-glucosinolate + adenosine 3',5'-bisphosphate. got7fsn_ti dhl 2009-04-13T04:07:32Z MetaCyc:RXNQT-4332 molecular_function owl:Class
GO:0018761 biolink:NamedThing bromoxynil nitrilase activity Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil. got7fsn_ti 3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity|bromoxynil-specific nitrilase activity MetaCyc:3.5.5.6-RXN|UM-BBD_enzymeID:e0357|EC:3.5.5.6|KEGG_REACTION:R04349|RHEA:22100 molecular_function owl:Class
GO:0046970 biolink:NamedThing NAD-dependent histone deacetylase activity (H4-K16 specific) Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 16) + H2O = histone H4 L-lysine (position 16) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 16 of the histone H4 protein. got7fsn_ti molecular_function owl:Class
GO:0110010 biolink:NamedThing basolateral protein secretion The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base. got7fsn_ti kmv biological_process owl:Class
GO:0008843 biolink:NamedThing endochitinase activity Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain. got7fsn_ti molecular_function owl:Class
GO:0004568 biolink:NamedThing chitinase activity Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. got7fsn_ti beta-1,4-poly-N-acetyl glucosamidinase activity|poly-beta-glucosaminidase activity|poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity|1,4-beta-poly-N-acetylglucosaminidase activity|chitodextrinase activity MetaCyc:3.2.1.14-RXN|Reactome:R-HSA-6786421|EC:3.2.1.14 molecular_function owl:Class
GO:0102631 biolink:NamedThing caffeoylglucose 3-O-methyltransferase activity Catalysis of the reaction: 1-O-caffeoyl-beta-D-glucose + S-adenosyl-L-methionine <=> 1-O-feruloyl-beta-D-glucose + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-15537 molecular_function owl:Class
GO:0031594 biolink:NamedThing neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. got7fsn_ti NMJ|motor endplate In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. Wikipedia:Neuromuscular_junction|NIF_Subcellular:sao1124888485 cellular_component owl:Class
GO:0071132 biolink:NamedThing alphaX-beta2 integrin-ICAM-4 complex A protein complex that consists of an alphaX-beta2 integrin complex bound to intercellular adhesion molecule 4. got7fsn_ti ITGAX-ITGB2-ICAM4 complex mah 2009-11-13T02:28:30Z cellular_component owl:Class
GO:0001531 biolink:NamedThing interleukin-21 receptor binding Binding to an interleukin-21 receptor. got7fsn_ti IL-21|interleukin-21 receptor ligand molecular_function owl:Class
GO:0035145 biolink:NamedThing exon-exon junction complex A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. got7fsn_ti EJC|exon junction complex cellular_component owl:Class
GO:0017187 biolink:NamedThing peptidyl-glutamic acid carboxylation The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase. got7fsn_ti See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'. RESID:AA0032 biological_process owl:Class
GO:0140291 biolink:NamedThing peptidyl-glutamate ADP-deribosylation The removal of ADP-ribose from ADP-ribosylglutamate. got7fsn_ti pg 2018-11-22T14:34:24Z biological_process owl:Class
GO:0032623 biolink:NamedThing interleukin-2 production The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-2 secretion|interleukin-2 biosynthetic process|IL-2 production GO:0070970|GO:0042094 biological_process owl:Class
GO:0098025 biolink:NamedThing virus tail, baseplate Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached. got7fsn_ti tail tip|tail structure|bacteriophage baseplate Tail fibers are often attached to the baseplate of Caudovirales (tailed bacteriophages with dsDNA genomes). Sometimes referred to as the tail tip or tip structure in Siphoviridae. bm 2012-07-19T14:16:51Z cellular_component owl:Class
GO:0004996 biolink:NamedThing thyroid-stimulating hormone receptor activity Combining with thyroid-stimulating hormone to initiate a change in cell activity. got7fsn_ti TSH receptor activity|thyroid stimulating hormone receptor activity|thyrotropin receptor Wikipedia:Thyrotropin_receptor molecular_function owl:Class
GO:0003274 biolink:NamedThing endocardial cushion fusion The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping. got7fsn_ti dph 2009-10-20T09:26:32Z biological_process owl:Class
GO:0031750 biolink:NamedThing D3 dopamine receptor binding Binding to a D3 dopamine receptor. got7fsn_ti D3 dopamine receptor ligand molecular_function owl:Class
GO:0060408 biolink:NamedThing regulation of acetylcholine metabolic process Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. got7fsn_ti biological_process owl:Class
GO:0102138 biolink:NamedThing 7-oxatyphasterol synthase activity Catalysis of the reaction: H+ + typhasterol + NADPH + O2 <=> 7-oxatyphasterol + NADP + H2O. got7fsn_ti MetaCyc:RXN-11538 molecular_function owl:Class
OBO:CARO_0000000 biolink:NamedThing got7fsn_ti owl:Class
GO:0140133 biolink:NamedThing suppression by symbiont of host cytokine production Any process in which a symbiont stops, prevents, or reduces the rate or extent of cytokine production by the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti suppression by symbiont of host cytokine secretion|negative regulation by symbiont of host cytokine production https://github.com/geneontology/go-ontology/issues/14553 pg 2017-11-14T07:07:04Z biological_process owl:Class
GO:0033898 biolink:NamedThing Bacillus subtilis ribonuclease activity Catalysis of the endonucleolytic cleavage to 2',3'-cyclic nucleotides. got7fsn_ti proteus mirabilis RNase activity|ribonucleate nucleotido-2'-transferase (cyclizing) activity EC:4.6.1.22|MetaCyc:3.1.27.2-RXN molecular_function owl:Class
GO:0071550 biolink:NamedThing death-inducing signaling complex assembly A process of protein complex assembly in which the arrangement and bonding together of the set of components that form the protein complex is mediated by a death domain (DD) interaction, as part of the extrinsic apoptotic signaling pathway. got7fsn_ti DISC formation|death-inducing signalling complex assembly|death-inducing signaling complex formation|death domain-mediated complex assembly|DD-mediated complex assembly|DISC assembly|death domain-mediated complex assembly involved in extrinsic apoptotic pathway mah 2010-01-13T02:48:38Z biological_process owl:Class
GO:1990899 biolink:NamedThing meiotic DNA double-strand break resectioning The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends. got7fsn_ti al 2015-11-10T17:23:07Z biological_process owl:Class
GO:1900813 biolink:NamedThing monodictyphenone metabolic process The chemical reactions and pathways involving monodictyphenone. got7fsn_ti monodictyphenone metabolism di 2012-06-04T10:11:03Z biological_process owl:Class
GO:0097116 biolink:NamedThing gephyrin clustering involved in postsynaptic density assembly The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses. got7fsn_ti Geph clustering pr 2011-07-31T05:42:29Z biological_process owl:Class
GO:0035418 biolink:NamedThing protein localization to synapse Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. got7fsn_ti protein localisation to synapse bf 2010-03-29T10:58:53Z biological_process owl:Class
GO:0044381 biolink:NamedThing glucose import in response to insulin stimulus The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus. got7fsn_ti cellular glucose import in response to insulin stimulus jl 2011-12-08T02:44:01Z biological_process owl:Class
GO:0046323 biolink:NamedThing glucose import The directed movement of the hexose monosaccharide glucose into a cell or organelle. got7fsn_ti glucose uptake Wikipedia:Glucose_uptake biological_process owl:Class
GO:0042616 biolink:NamedThing paclitaxel metabolic process The chemical reactions and pathways involving paclitaxel, a tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. got7fsn_ti paclitaxel metabolism|taxol metabolic process|taxol metabolism biological_process owl:Class
GO:0034734 biolink:NamedThing transcription factor TFIIIC1 complex A transcription factor complex that forms part of the TFIIIC complex, observed in human. The complex is poorly characterized, but contains the 250-kDa form of HsBdp1, and is thought to include nuclear factor 1 (NF1). It stimulates binding by human TFIIIC2 and is required for transcription activity. got7fsn_ti cellular_component owl:Class
GO:0102695 biolink:NamedThing UDP-glucose:cis-zeatin 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin <=> H+ + cis-zeatin-7-N-glucoside + UDP. got7fsn_ti MetaCyc:RXN-4733 molecular_function owl:Class
GO:0008807 biolink:NamedThing carboxyvinyl-carboxyphosphonate phosphorylmutase activity Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2. got7fsn_ti 1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)|carboxyphosphonoenolpyruvate phosphonomutase activity|CPEP phosphonomutase activity RHEA:14045|EC:2.7.8.23|MetaCyc:2.7.8.23-RXN molecular_function owl:Class
GO:0018125 biolink:NamedThing peptidyl-cysteine methylation The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine. got7fsn_ti RESID:AA0234 biological_process owl:Class
GO:0047703 biolink:NamedThing beta-nitroacrylate reductase activity Catalysis of the reaction: 3-nitropropanoate + NADP(+) = 3-nitroacrylate + H(+) + NADPH. got7fsn_ti b-nitroacrylate reductase activity|3-nitropropanoate:NADP+ oxidoreductase activity KEGG_REACTION:R03900|MetaCyc:BETA-NITROACRYLATE-REDUCTASE-RXN|RHEA:23892|EC:1.3.1.16 molecular_function owl:Class
GO:0072218 biolink:NamedThing metanephric ascending thin limb development The process whose specific outcome is the progression of a metanephric ascending thin limb over time, from its formation to the mature structure. The metanephric ascending thin limb is a segment of a nephron tubule in the metanephros lying in the inner medulla that is permeable to ions but not to water and has a simple epithelium; active transepithelial solute transport is absent. got7fsn_ti mah 2010-03-18T03:34:42Z biological_process owl:Class
GO:0033777 biolink:NamedThing lithocholate 6beta-hydroxylase activity Catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+). got7fsn_ti cytochrome P450 3A10/lithocholic acid 6beta-hydroxylase activity|lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity|lithocholate 6beta-monooxygenase activity|6beta-hydroxylase activity|CYP3A10 KEGG_REACTION:R07203|MetaCyc:1.14.13.94-RXN|RHEA:18857|EC:1.14.14.138 molecular_function owl:Class
GO:0033944 biolink:NamedThing beta-galactofuranosidase activity Catalysis of the hydrolysis of terminal non-reducing beta-D-galactofuranosides, releasing galactose. got7fsn_ti beta-D-galactofuranosidase activity|exo-beta-galactofuranosidase activity|beta-D-galactofuranoside hydrolase activity|exo-beta-D-galactofuranosidase activity MetaCyc:3.2.1.146-RXN|EC:3.2.1.146 molecular_function owl:Class
GO:0019711 biolink:NamedThing peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid. got7fsn_ti peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid|peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid|peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid biological_process owl:Class
GO:0036353 biolink:NamedThing histone H2A-K119 monoubiquitination The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms. got7fsn_ti histone H2A monoubiquitination (H2A-K119) bf 2012-09-19T11:52:25Z biological_process owl:Class
GO:1900561 biolink:NamedThing dehydroaustinol metabolic process The chemical reactions and pathways involving dehydroaustinol. got7fsn_ti dehydroaustinol metabolism di 2012-05-15T06:27:35Z biological_process owl:Class
GO:0006706 biolink:NamedThing steroid catabolic process The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. got7fsn_ti steroid breakdown|steroid degradation|steroid catabolism biological_process owl:Class
GO:0102664 biolink:NamedThing indole-3-acetyl-leucine synthetase activity Catalysis of the reaction: indole-3-acetate + L-leucine + ATP <=> H+ + indole-3-acetyl-leucine + diphosphoric acid + AMP. got7fsn_ti MetaCyc:RXN-2945 molecular_function owl:Class
GO:0036298 biolink:NamedThing recombinational interstrand cross-link repair Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. got7fsn_ti recombination-dependent interstrand cross-link repair bf 2012-08-07T11:11:59Z biological_process owl:Class
GO:0047568 biolink:NamedThing 3-oxo-5-beta-steroid 4-dehydrogenase activity Catalysis of the reaction: a 3-oxo-5-beta-steroid + acceptor = a 3-oxo-D4-steroid + reduced acceptor. got7fsn_ti 3-oxo-5beta-steroid:(acceptor) delta4-oxidoreductase activity|3-oxo-5beta-steroid 4-dehydrogenase activity|3-oxo-5beta-steroid:acceptor delta4-oxidoreductase activity|delta4-3-ketosteroid 5-beta-reductase activity RHEA:24172|EC:1.3.99.6|MetaCyc:3-OXO-5-BETA-STEROID-4-DEHYDROGENASE-RXN molecular_function owl:Class
GO:1900805 biolink:NamedThing brevianamide F biosynthetic process The chemical reactions and pathways resulting in the formation of brevianamide F. got7fsn_ti cyclo-L-tryptophanyl-L-proline biosynthetic process|cyclo-(Trp-Pro) formation|cyclo-(Trp-Pro) biosynthesis|cyclo-L-tryptophanyl-L-proline formation|C16H17N3O2 synthesis|cyclo-L-tryptophanyl-L-proline biosynthesis|cyclo-L-Trp-L-Pro synthesis|L-prolyl-L-tryptophan anhydride biosynthesis|C16H17N3O2 anabolism|cyclo-L-Trp-L-Pro anabolism|tryptophan-proline diketopiperazine anabolism|cyclo-(Trp-Pro) biosynthetic process|cyclo-L-Trp-L-Pro formation|C16H17N3O2 formation|L-prolyl-L-tryptophan anhydride synthesis|L-prolyl-L-tryptophan anhydride formation|C16H17N3O2 biosynthesis|L-prolyl-L-tryptophan anhydride anabolism|brevianamide F formation|L-tryptophyl-L-proline cyclic anhydride formation|L-tryptophyl-L-proline cyclic anhydride anabolism|L-tryptophyl-L-proline cyclic anhydride biosynthetic process|tryptophan-proline diketopiperazine synthesis|cyclo-(Trp-Pro) synthesis|cyclo-L-Trp-L-Pro biosynthesis|cyclo-L-tryptophanyl-L-proline synthesis|tryptophan-proline diketopiperazine biosynthesis|brevianamide F anabolism|tryptophan-proline diketopiperazine biosynthetic process|brevianamide F biosynthesis|cyclo-L-tryptophanyl-L-proline anabolism|L-tryptophyl-L-proline cyclic anhydride synthesis|cyclo-(Trp-Pro) anabolism|cyclo-L-Trp-L-Pro biosynthetic process|L-tryptophyl-L-proline cyclic anhydride biosynthesis|C16H17N3O2 biosynthetic process|brevianamide F synthesis|tryptophan-proline diketopiperazine formation|L-prolyl-L-tryptophan anhydride biosynthetic process di 2012-06-04T09:52:48Z biological_process owl:Class
GO:0016989 biolink:NamedThing sigma factor antagonist activity The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity. got7fsn_ti anti-sigma factor activity molecular_function owl:Class
GO:0043793 biolink:NamedThing beta-ribofuranosylaminobenzene 5'-phosphate synthase activity Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate. got7fsn_ti beta-RFAP synthase activity MetaCyc:RXN-8124 molecular_function owl:Class
GO:0035491 biolink:NamedThing positive regulation of leukotriene production involved in inflammatory response Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response. got7fsn_ti bf 2010-04-26T10:50:14Z biological_process owl:Class
GO:0070279 biolink:NamedThing vitamin B6 binding Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate. got7fsn_ti molecular_function owl:Class
GO:0044219 biolink:NamedThing host cell plasmodesma A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell. got7fsn_ti jl 2009-11-12T02:50:52Z cellular_component owl:Class
GO:1900770 biolink:NamedThing fumitremorgin B metabolic process The chemical reactions and pathways involving fumitremorgin B. got7fsn_ti fumitremorgin B metabolism|Lanosulin metabolic process|Lanosulin metabolism di 2012-06-04T09:25:18Z biological_process owl:Class
GO:1990407 biolink:NamedThing calcitonin gene-related peptide binding Binding to calcitonin gene-related peptide (CGRP). got7fsn_ti CGRP polypeptide binding|calcitonin-gene-related polypeptide binding|calcitonin-gene-related peptide binding An example of this is CALCRL in human (Q16602) in PMID:10882736 (inferred from direct assay/mutant phenotype/etc.). bhm 2014-07-02T14:22:06Z molecular_function owl:Class
GO:0033808 biolink:NamedThing 6'-deoxychalcone synthase activity Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = 4 CoA + isoliquiritigenin + 3 CO2 + NADP+ + H2O. got7fsn_ti malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing, reducing) activity EC:2.3.1.170|RHEA:10584|MetaCyc:RXN-3142 molecular_function owl:Class
GO:0021959 biolink:NamedThing cuneatus tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb. got7fsn_ti tract of Burdach morphogenesis biological_process owl:Class
GO:0075513 biolink:NamedThing caveolin-mediated endocytosis of virus by host cell Any caveolin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins when material is taken up into plasma membrane caveolae - specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane - which then pinch off to form endocytic caveolar carriers containing the virus. got7fsn_ti viral entry into host cell via caveolae-mediated endocytosis|viral entry into host cell via caveolin-mediated endocytosis|viral penetration via caveolae-mediated endocytosis followed by endosome disruption jl 2011-07-27T02:40:04Z VZ:976 biological_process owl:Class
GO:0050012 biolink:NamedThing juglone 3-hydroxylase activity Catalysis of the reaction: 2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H+. got7fsn_ti juglone 3-monooxygenase activity|5-hydroxy-1,4-naphthoquinone,hydrogen-donor:oxygen oxidoreductase (3-hydroxylating)|juglone hydroxylase activity|naphthoquinone hydroxylase activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.14.99.27. KEGG_REACTION:R04327|EC:1.17.3.4|MetaCyc:JUGLONE-3-MONOOXYGENASE-RXN|RHEA:18745 molecular_function owl:Class
GO:1903502 biolink:NamedThing translation repressor complex A protein complex which is capable of translation repressor activity. got7fsn_ti An example of this is Eif4e in drome (P48598) in PMID:14723848 (inferred from physical interaction). bhm 2014-09-30T12:44:27Z cellular_component owl:Class
GO:0033789 biolink:NamedThing phenylacetyl-CoA dehydrogenase activity Catalysis of the reaction: 2 1,4-benzoquinone + H(2)O + phenylacetyl-CoA = 2 hydroquinone + phenylglyoxylyl-CoA. got7fsn_ti phenylacetyl-CoA:acceptor oxidoreductase activity|phenylacetyl-CoA:quinone oxidoreductase activity MetaCyc:1.17.5.1-RXN|KEGG_REACTION:R07222|RHEA:15705|EC:1.17.5.1 molecular_function owl:Class
GO:0102054 biolink:NamedThing maleylpyruvate hydrolase activity Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O <=> H+ + maleate(2-) + pyruvate. got7fsn_ti MetaCyc:RXN-10447|RHEA:47956 molecular_function owl:Class
GO:0106276 biolink:NamedThing biliberdin reductase NAD+ activity Catalysis of the reaction: bilirubin + NAD+ = biliverdin + NADH+ H+. got7fsn_ti hjd 2020-07-02T01:48:07Z RHEA:15797|EC:1.3.1.24 molecular_function owl:Class
GO:0004074 biolink:NamedThing biliverdin reductase (NAD(P)+) activity Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+. got7fsn_ti bilirubin:NAD(P)+ oxidoreductase activity Reactome:R-HSA-189384|MetaCyc:BILIVERDIN-REDUCTASE-RXN|EC:1.3.1.24 molecular_function owl:Class
GO:0050206 biolink:NamedThing oximinotransferase activity Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate. got7fsn_ti oximinotransaminase activity|transoximinase activity|transoximase activity|oximase activity|pyruvate-acetone oximinotransferase activity GO:0016770 EC:2.6.3.1|MetaCyc:OXIMINOTRANSFERASE-RXN|RHEA:11624|KEGG_REACTION:R03796 molecular_function owl:Class
GO:0034610 biolink:NamedThing oligodeoxyribonucleotidase activity Catalysis of the exonucleolytic cleavage of oligodeoxyribonucleotides to yield deoxyribonucleoside 5'-phosphates. got7fsn_ti DNA oligonucleotidase activity molecular_function owl:Class
GO:0030768 biolink:NamedThing 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+). got7fsn_ti NMT activity|S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity|3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity|16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity|S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity EC:2.1.1.99|RHEA:11336|MetaCyc:2.1.1.99-RXN|KEGG_REACTION:R04013 molecular_function owl:Class
GO:0018600 biolink:NamedThing alpha-pinene dehydrogenase activity Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol. got7fsn_ti UM-BBD_reactionID:r0709|EC:1.14.-.- molecular_function owl:Class
GO:0015452 biolink:NamedThing methyl transfer-driven active transmembrane transporter activity Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. got7fsn_ti Methyltransfer-driven transporters TC:3.C molecular_function owl:Class
GO:0097666 biolink:NamedThing SCF-Met30/Pof1 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe). got7fsn_ti pr 2014-10-06T10:27:49Z cellular_component owl:Class
GO:0090669 biolink:NamedThing telomerase RNA stabilization Prevention of degradation of telomerase RNA (TERC) molecules. got7fsn_ti TERC stabilization tb 2015-12-17T14:01:11Z biological_process owl:Class
GO:0035761 biolink:NamedThing dorsal motor nucleus of vagus nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state. got7fsn_ti bf 2011-03-29T02:45:50Z biological_process owl:Class
GO:0007616 biolink:NamedThing long-term memory The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. got7fsn_ti Wikipedia:Long-term_memory biological_process owl:Class
GO:1990966 biolink:NamedThing ATP generation from poly-ADP-D-ribose The process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. got7fsn_ti sp 2016-06-16T09:41:35Z biological_process owl:Class
GO:0050634 biolink:NamedThing phloroisovalerophenone synthase activity Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one. got7fsn_ti valerophenone synthase activity|3-methyl-1-(trihydroxyphenyl)butan-1-one synthase activity|isovaleryl-CoA:malonyl-CoA acyltransferase activity RHEA:23572|MetaCyc:2.3.1.156-RXN|EC:2.3.1.156 molecular_function owl:Class
GO:0099155 biolink:NamedThing synaptic transmission, noradrenergic The vesicular release of noradrenaline (norepinephrine) a presynapse, across a chemical synapse, the subsequent activation of noradrenaline receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. got7fsn_ti noradrenergic synaptic transmission dos 2017-07-05T14:36:55Z biological_process owl:Class
GO:0140459 biolink:NamedThing response to Gram-positive bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19278 pg 2020-04-30T07:33:34Z biological_process owl:Class
GO:0032498 biolink:NamedThing detection of muramyl dipeptide The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan. got7fsn_ti biological_process owl:Class
GO:0032495 biolink:NamedThing response to muramyl dipeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan. got7fsn_ti biological_process owl:Class
GO:0003944 biolink:NamedThing N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose. got7fsn_ti alpha-N-acetylglucosaminyl phosphodiesterase activity|lysosomal alpha-N-acetylglucosaminidase activity|2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity|phosphodiester glycosidase activity|glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity|alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity EC:3.1.4.45|RHEA:24372|MetaCyc:3.1.4.45-RXN molecular_function owl:Class
GO:0047513 biolink:NamedThing 1,2-alpha-L-fucosidase activity Catalysis of the reaction: H2O + methyl-2-alpha-L-fucopyranosyl-beta-D-galactoside = L-fucose + methyl beta-D-galactoside. got7fsn_ti 2-alpha-L-fucopyranosyl-beta-D-galactoside fucohydrolase activity|alpha-(1->2)-L-fucosidase activity|almond emulsin fucosidase activity|almond emulsin fucosidase II activity MetaCyc:12-ALPHA-L-FUCOSIDASE-RXN|EC:3.2.1.63|RHEA:10816 molecular_function owl:Class
GO:0097474 biolink:NamedThing retinal cone cell apoptotic process Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina. got7fsn_ti cone photoreceptor apoptotic process pr 2013-03-21T09:46:22Z biological_process owl:Class
GO:0051980 biolink:NamedThing iron-nicotianamine transmembrane transporter activity Enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other. got7fsn_ti Fe-NA chelate transporter activity molecular_function owl:Class
GO:0070222 biolink:NamedThing sulfide oxidation, using sulfide dehydrogenase A sulfide oxidation process that proceeds via the reaction catalyzed by sulfide dehydrogenase. got7fsn_ti sulphide oxidation, using sulfide dehydrogenase MetaCyc:PWY-5274 biological_process owl:Class
GO:0019908 biolink:NamedThing nuclear cyclin-dependent protein kinase holoenzyme complex Cyclin-dependent protein kinase (CDK) complex found in the nucleus. got7fsn_ti CDK holoenzyme cellular_component owl:Class
GO:0018012 biolink:NamedThing N-terminal peptidyl-alanine trimethylation The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine. got7fsn_ti RESID:AA0062 biological_process owl:Class
GO:0016938 biolink:NamedThing kinesin I complex A complex of two kinesin heavy chains and two kinesin light chains. got7fsn_ti cellular_component owl:Class
GO:1990097 biolink:NamedThing SeqA-DNA complex A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle. got7fsn_ti SeqA-hemimethylated DNA complex|SeqA-dsDNA complex|SeqA-hemimethylation dsDNA complex bhm 2013-05-13T11:18:11Z cellular_component owl:Class
GO:0047469 biolink:NamedThing 4-carboxymethyl-4-methylbutenolide mutase activity Catalysis of the reaction: 4-carboxymethyl-4-methylbut-2-en-1,4-olide = 4-carboxymethyl-3-methylbut-2-en-1,4-olide. got7fsn_ti 4-methyl-3-enelactone methyl isomerase activity|4-methyl-2-enelactone isomerase activity|4-methylmuconolactone methylisomerase activity|4-carboxymethyl-4-methylbut-2-en-1,4-olide methylmutase activity|4-methyl-2-enelactone methyl-isomerase activity EC:5.4.99.14|MetaCyc:5.4.99.14-RXN|KEGG_REACTION:R04510|RHEA:19237 molecular_function owl:Class
GO:0050017 biolink:NamedThing L-3-cyanoalanine synthase activity Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine. got7fsn_ti beta-cyano-L-alanine synthase activity|beta-cyanoalanine synthase activity|L-cysteine hydrogen-sulfide-lyase (adding hydrogen cyanide; L-3-cyanoalanine-forming)|L-cysteine hydrogen-sulfide-lyase (adding HCN)|beta-cyanoalanine synthetase activity RHEA:17821|MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN|EC:4.4.1.9 molecular_function owl:Class
GO:0033703 biolink:NamedThing 3beta-hydroxy-5beta-steroid dehydrogenase activity Catalysis of the reaction: 3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + H(+) + NADPH. got7fsn_ti 3beta-hydroxysteroid 5beta-progesterone oxidoreductase activity|3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase activity|3beta-hydroxysteroid 5beta-oxidoreductase activity EC:1.1.1.277|MetaCyc:1.1.1.277-RXN|KEGG_REACTION:R06166|RHEA:22944 molecular_function owl:Class
GO:0072747 biolink:NamedThing cellular response to chloramphenicol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus. got7fsn_ti mah 2012-08-31T12:33:30Z biological_process owl:Class
GO:0050037 biolink:NamedThing L-xylose 1-dehydrogenase activity Catalysis of the reaction: aldehydo-L-xylose + NADP(+) = L-xylono-1,4-lactone + H(+) + NADPH. got7fsn_ti L-xylose dehydrogenase activity|NADPH-xylose reductase activity|L-xylose:NADP+ 1-oxidoreductase activity KEGG_REACTION:R03586|EC:1.1.1.113|RHEA:15789|MetaCyc:L-XYLOSE-1-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0043807 biolink:NamedThing 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin. got7fsn_ti VOR|3-methyl-2-oxobutanoate synthase (ferredoxin) activity|2-oxoisovalerate ferredoxin reductase activity|2-ketoisovalerate ferredoxin reductase activity|keto-valine-ferredoxin oxidoreductase activity|ketoisovalerate oxidoreductase activity|branched-chain oxo acid ferredoxin reductase activity|3-methyl-2-oxobutanoate:ferredoxin oxidoreductase (decarboxylating; CoA-2-methylpropanoylating)|ketoisovalerate ferredoxin reductase activity|branched-chain ketoacid ferredoxin reductase activity EC:1.2.7.7|RHEA:11712|MetaCyc:1.2.7.7-RXN molecular_function owl:Class
GO:0004019 biolink:NamedThing adenylosuccinate synthase activity Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate. got7fsn_ti adenylosuccinate synthetase activity|IMP--aspartate ligase activity|succino-AMP synthetase activity|succinoadenylic kinosynthetase activity|IMP:L-aspartate ligase (GDP-forming) KEGG_REACTION:R01135|Reactome:R-HSA-111524|EC:6.3.4.4|RHEA:15753|MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN molecular_function owl:Class
GO:0050259 biolink:NamedThing ribose 1-dehydrogenase (NADP+) activity Catalysis of the reaction: H(2)O + NADP(+) + ribofuranose = D-ribonate + 2 H(+) + NADPH. got7fsn_ti D-ribose dehydrogenase (NADP+)|D-ribose:NADP+ 1-oxidoreductase activity|NADP-pentose-dehydrogenase activity EC:1.1.1.115|KEGG_REACTION:R01079|MetaCyc:RIBOSE-1-DEHYDROGENASE-NADP+-RXN|RHEA:11676 molecular_function owl:Class
GO:0047981 biolink:NamedThing histidine N-acetyltransferase activity Catalysis of the reaction: L-histidine + acetyl-CoA = N(alpha)-acetyl-L-histidine + CoA + H(+). got7fsn_ti acetyl-CoA:L-histidine N-acetyltransferase activity|acetylhistidine synthetase activity|histidine acetyltransferase activity KEGG_REACTION:R01160|EC:2.3.1.33|MetaCyc:HISTIDINE-N-ACETYLTRANSFERASE-RXN|RHEA:24596 molecular_function owl:Class
GO:0140630 biolink:NamedThing all-trans-phytoene synthase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate -> all-trans-phytoene + 2 diphosphate. got7fsn_ti phytoene synthase activity https://github.com/geneontology/go-ontology/issues/21165 pg 2021-03-25T18:04:01Z molecular_function owl:Class
GO:0035035 biolink:NamedThing histone acetyltransferase binding Binding to an histone acetyltransferase. got7fsn_ti histone acetylase binding molecular_function owl:Class
GO:0030623 biolink:NamedThing U5 snRNA binding Binding to a U5 small nuclear RNA (U5 snRNA). got7fsn_ti molecular_function owl:Class
GO:0047161 biolink:NamedThing tartronate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: hydroxymalonate + sinapoyl-CoA = CoA + sinapoyltartronate. got7fsn_ti hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase activity|sinapoyl-CoA:2-hydroxymalonate O-(hydroxycinnamoyl)transferase activity|tartronate sinapoyltransferase activity EC:2.3.1.106|MetaCyc:2.3.1.106-RXN|KEGG_REACTION:R03965|RHEA:10952 molecular_function owl:Class
GO:1990456 biolink:NamedThing mitochondrion-endoplasmic reticulum membrane tethering The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles. got7fsn_ti mitochondrion-ER attachment|mitochondrion-endoplasmic reticulum tethering|mitochondrion-ER membrane tethering|mitochondrion-endoplasmic reticulum attachment|mitochondrion-ER tethering mcc 2014-08-14T13:32:30Z biological_process owl:Class
GO:0052818 biolink:NamedThing heteroglycan 3-alpha-mannosyltransferase activity Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP. got7fsn_ti GDP-mannose:heteroglycan 3-alpha-D-mannosyltransferase activity|GDP mannose 3-alpha-mannosyltransferase activity|guanosine diphosphomannose-heteroglycan 3-alpha-mannosyltransferase activity|heteropolysaccharide 3-alpha-mannosyltransferase activity ai 2011-10-27T12:36:10Z MetaCyc:RXN-7992|KEGG_REACTION:R03769|EC:2.4.1.48 molecular_function owl:Class
GO:0102961 biolink:NamedThing 4,4'-diapophytofluene desaturase activity Catalysis of the reaction: all-trans-4,4'-diapophytofluene + FAD + H+ = all-trans-4,4'-diapo-zeta-carotene + FADH2. got7fsn_ti MetaCyc:RXN-9304|RHEA:31399 molecular_function owl:Class
GO:0032398 biolink:NamedThing MHC class Ib protein complex A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. got7fsn_ti cellular_component owl:Class
GO:0006579 biolink:NamedThing amino-acid betaine catabolic process The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid. got7fsn_ti betaine degradation|betaine catabolic process|betaine breakdown|betaine catabolism biological_process owl:Class
GO:0044179 biolink:NamedThing hemolysis in other organism The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another. got7fsn_ti hemolysis of erythrocytes in other organism|hemolysis of red blood cells in other organism|hemolysis of cells in other organism|hemolysis of RBCs in other organism jl 2009-09-04T03:36:00Z biological_process owl:Class
GO:0031824 biolink:NamedThing type 1E serotonin receptor binding Binding to a type 1E serotonin receptor. got7fsn_ti type 1E serotonin receptor ligand|5-hydroxytryptamine 1E receptor binding molecular_function owl:Class
GO:0098816 biolink:NamedThing mini excitatory postsynaptic potential A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse. got7fsn_ti biological_process owl:Class
GO:0008666 biolink:NamedThing 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H(2)O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA. got7fsn_ti tetrahydropicolinate succinylase activity|succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity|tetrahydrodipicolinate N-succinyltransferase activity|succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity|tetrahydrodipicolinate succinyltransferase activity|tetrahydrodipicolinate succinylase activity|THDP N-succinyltransferase activity|succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity KEGG_REACTION:R04365|MetaCyc:TETHYDPICSUCC-RXN|RHEA:17325|EC:2.3.1.117 molecular_function owl:Class
GO:0008307 biolink:NamedThing structural constituent of muscle The action of a molecule that contributes to the structural integrity of a muscle fiber. got7fsn_ti molecular_function owl:Class
GO:0097544 biolink:NamedThing ciliary shaft The mid part of a cilium between the ciliary base and ciliary tip that extends into the extracellular space. got7fsn_ti cilium shaft|flagellar shaft|cilial shaft|flagellum shaft Note that 'ciliary shaft' is sparingly used in the literature to denote the projecting part of the cilium; many authors would refer to the axoneme instead. However, the definition of GO:0005930 'axoneme' is rather stringent, and the localization of many ciliary proteins would not fit that definition. Also, note that cilia and eukaryotic flagella are deemed to be equivalent. pr 2013-12-12T11:17:30Z cellular_component owl:Class
GO:0102378 biolink:NamedThing steviolmonoside glucosyltransferase activity Catalysis of the reaction: steviolmonoside + UDP-alpha-D-glucose = rubusoside + UDP + H+. got7fsn_ti MetaCyc:RXN-13512 molecular_function owl:Class
GO:0050440 biolink:NamedThing 2-methylcitrate synthase activity Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+). got7fsn_ti MCS activity|methylcitrate synthetase activity|2-methylcitrate oxaloacetate-lyase activity|methylcitrate synthase activity|propanoyl-CoA:oxaloacetate C-propanoyltransferase (thioester-hydrolysing, 1-carboxyethyl-forming) EC:2.3.3.5|RHEA:23780|KEGG_REACTION:R00931|MetaCyc:2-METHYLCITRATE-SYNTHASE-RXN molecular_function owl:Class
GO:0035134 biolink:NamedThing post-embryonic dorsal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins. got7fsn_ti biological_process owl:Class
GO:0102318 biolink:NamedThing 2-deoxystreptamine glucosyltransferase activity Catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+. got7fsn_ti RHEA:34063|MetaCyc:RXN-13121|EC:2.4.1.284 molecular_function owl:Class
GO:0004960 biolink:NamedThing thromboxane receptor activity Combining with a thromboxane (TXA) to initiate a change in cell activity. got7fsn_ti TXA receptor activity molecular_function owl:Class
GO:0062182 biolink:NamedThing all-trans retinoic acid 4-hydrolase activity Catalysis of the reaction: all-trans-retinoate + O2 + reduced [NADPH--hemoprotein reductase] = all-trans-(4S)-hydroxyretinoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti dph 2019-11-26T18:36:06Z RHEA:51492 molecular_function owl:Class
GO:0017058 biolink:NamedThing FH1 domain binding Binding to a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain. got7fsn_ti molecular_function owl:Class
GO:0021968 biolink:NamedThing corticospinal neuron axon guidance through the internal capsule The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues. got7fsn_ti corticospinal neuron axon pathfinding through the internal capsule biological_process owl:Class
GO:0060842 biolink:NamedThing arterial endothelial cell differentiation The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries. got7fsn_ti dph 2009-08-12T10:41:34Z biological_process owl:Class
GO:0036519 biolink:NamedThing chemorepulsion of serotonergic neuron axon The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. got7fsn_ti chemorepulsion of 5-HT axon|chemorepulsion of serotonergic axon bf 2015-12-17T11:31:16Z biological_process owl:Class
GO:0033460 biolink:NamedThing GAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GAG codon. got7fsn_ti glutamic acid tRNA Note that in the standard genetic code, GAG codes for glutamic acid. molecular_function owl:Class
GO:0047117 biolink:NamedThing enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-D2-enoyl-[acyl-carrier protein] + NADPH + H+. got7fsn_ti enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|enoyl-ACP reductase (NADPH, A-specific) activity|enoyl-[acyl-carrier protein] reductase (NADPH, A-specific) activity|enoyl-acyl-carrier-protein reductase (NADPH, A-specific)|enoyl-ACp reductase activity|acyl-acyl-carrier-protein:NADP+ oxidoreductase (A-specific) EC:1.3.1.39|MetaCyc:1.3.1.39-RXN molecular_function owl:Class
GO:0043803 biolink:NamedThing hydroxyneurosporene-O-methyltransferase activity Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = H(+) + S-adenosyl-L-homocysteine + spheroidene. got7fsn_ti 1-hydroxycarotenoid O-methylase|1-HO-carotenoid methylase|1-hydroxycarotenoid methylase|demethylspheroidene O-methyltransferase EC:2.1.1.210|RHEA:30903 molecular_function owl:Class
GO:0034503 biolink:NamedThing protein localization to nucleolar rDNA repeats Any process in which a protein is transported to, or maintained at, the rDNA repeats on a chromosome in the nucleolus. got7fsn_ti protein localisation to nucleolar rDNA repeats|condensin localization to nucleolar rDNA repeats biological_process owl:Class
GO:0043768 biolink:NamedThing S-ribosylhomocysteine lyase activity Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine. got7fsn_ti S-(5-deoxy-D-ribos-5-yl)-L-homocysteine homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]|S-ribosylhomocysteinase activity|LuxS|ribosylhomocysteinase activity GO:0019138 KEGG_REACTION:R01291|EC:4.4.1.21|RHEA:17753|MetaCyc:RIBOSYLHOMOCYSTEINASE-RXN molecular_function owl:Class
GO:0075529 biolink:NamedThing establishment of latency as a circular episome A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure. got7fsn_ti establishment of circular plasmid latency|establishment of latency as a circular plasmid jl 2011-08-04T03:08:17Z biological_process owl:Class
GO:0047896 biolink:NamedThing formaldehyde transketolase activity Catalysis of the reaction: D-xylulose 5-phosphate + formaldehyde = glyceraldehyde 3-phosphate + glycerone. got7fsn_ti glycerone synthase activity|D-xylulose-5-phosphate:formaldehyde glycolaldehydetransferase activity|dihydroxyacetone synthase activity|DHAS activity EC:2.2.1.3|RHEA:24264|MetaCyc:FORMALDEHYDE-TRANSKETOLASE-RXN molecular_function owl:Class
GO:0120283 biolink:NamedThing protein serine/threonine kinase binding Binding to a protein serine/threonine kinase. got7fsn_ti https://github.com/geneontology/go-ontology/issues/15218 krc 2020-11-17T16:26:36Z molecular_function owl:Class
GO:0001818 biolink:NamedThing negative regulation of cytokine production Any process that stops, prevents, or reduces the rate of production of a cytokine. got7fsn_ti downregulation of cytokine biosynthetic process|down-regulation of cytokine biosynthetic process|negative regulation of cytokine anabolism|negative regulation of cytokine biosynthetic process|inhibition of cytokine biosynthetic process|down-regulation of cytokine production|down regulation of cytokine production|negative regulation of cytokine secretion|down regulation of cytokine biosynthetic process|negative regulation of cytokine synthesis|negative regulation of cytokine formation|downregulation of cytokine production|inhibition of cytokine production|negative regulation of cytokine biosynthesis GO:0050710|GO:0042036 biological_process owl:Class
GO:0042048 biolink:NamedThing olfactory behavior The behavior of an organism in response to an odor. got7fsn_ti behavioural response to odour|olfactory behaviour|behavioral response to smell|behavioural response to scent|behavioral response to scent|behavioural response to smell biological_process owl:Class
GO:0039658 biolink:NamedThing TBK1-IKKE-DDX3 complex A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3. got7fsn_ti TBK1-IKBKE-DDX3 complex bf 2013-07-03T16:59:27Z cellular_component owl:Class
GO:0019500 biolink:NamedThing cyanide catabolic process The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. got7fsn_ti cyanide degradation|cyanide breakdown|cyanide catabolism MetaCyc:P401-PWY biological_process owl:Class
GO:0036223 biolink:NamedThing cellular response to adenine starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine. got7fsn_ti cellular response to adenine deprivation bf 2012-05-09T02:26:52Z biological_process owl:Class
GO:0060763 biolink:NamedThing mammary duct terminal end bud growth The morphogenetic growth of the large, club-shaped terminal end of a mammary gland duct during prepubertal growth and during puberty. got7fsn_ti dph 2009-07-06T07:33:50Z biological_process owl:Class
GO:0106245 biolink:NamedThing L-serine-phosphatidylethanolamine phosphatidyltransferase activity Catalysis of the reaction: L-1-phosphatidylethanolamine + L-serine <=> L-1-phosphatidylserine + ethanolamine. got7fsn_ti hjd 2020-01-22T15:27:57Z RHEA:27606|EC:2.7.8.29 molecular_function owl:Class
GO:0050273 biolink:NamedThing S-succinylglutathione hydrolase activity Catalysis of the reaction: S-succinylglutathione + H(2)O = glutathione + H(+) + succinate. got7fsn_ti MetaCyc:S-SUCCINYLGLUTATHIONE-HYDROLASE-RXN|EC:3.1.2.13|KEGG_REACTION:R00499|RHEA:16713 molecular_function owl:Class
GO:1900794 biolink:NamedThing terrequinone A metabolic process The chemical reactions and pathways involving terrequinone A. got7fsn_ti terrequinone A metabolism di 2012-06-04T09:45:20Z biological_process owl:Class
GO:1990208 biolink:NamedThing positive regulation by symbiont of RNA levels in host Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti ml 2013-10-08T13:31:41Z biological_process owl:Class
GO:0031278 biolink:NamedThing alpha-1,2-galactosyltransferase activity Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage. got7fsn_ti molecular_function owl:Class
GO:1990714 biolink:NamedThing hydroxyproline O-galactosyltransferase activity Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone. got7fsn_ti HPGT tb 2015-03-26T23:22:09Z molecular_function owl:Class
GO:0047719 biolink:NamedThing indole 2,3-dioxygenase activity Catalysis of the reaction: indole + O(2) = 2-formamidobenzaldehyde. got7fsn_ti indole:O2 oxidoreductase activity|indole oxidase activity|indole-oxygen 2,3-oxidoreductase (decyclizing)|indole:oxygen 2,3-oxidoreductase (decyclizing)|IDO MetaCyc:INDOLE-23-DIOXYGENASE-RXN|KEGG_REACTION:R02338|RHEA:11212|EC:1.13.11.17 molecular_function owl:Class
GO:0052622 biolink:NamedThing ATP dimethylallyltransferase activity Catalysis of the reaction: delta(2)-isopentenyl diphosphate + ATP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-triphosphate. got7fsn_ti dimethylallyl-diphosphate:ATP dimethylallyltransferase activity|ATP isopentenyltransferase activity|2-isopentenyl-diphosphate:ATP 2-isopentenyltransferase activity|2-isopentenyl-diphosphate:ATP delta2-isopentenyltransferase activity ai 2010-08-26T10:45:38Z MetaCyc:RXN-4303|EC:2.5.1.-|KEGG_REACTION:R08052 molecular_function owl:Class
GO:0008667 biolink:NamedThing 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH. got7fsn_ti 2,3-DHB dehydrogenase activity|2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity KEGG_REACTION:R01505|EC:1.3.1.28|RHEA:23824|MetaCyc:DHBDEHYD-RXN molecular_function owl:Class
GO:0090397 biolink:NamedThing stigma papilla A plant cell papilla that is part of a stigma papilla cell. got7fsn_ti Part of stigma papilla cell (PO:0025168). tb 2010-12-15T03:26:20Z cellular_component owl:Class
GO:0060729 biolink:NamedThing intestinal epithelial structure maintenance A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium. got7fsn_ti maintenance of intestinal epithelium|epithelial structure maintenance of intestine dph 2009-06-12T01:44:52Z biological_process owl:Class
GO:0098616 biolink:NamedThing selenate adenylyltransferase (ATP) activity Catalysis of the reaction: ATP + H2SeO4 => diphosphate + adenylylselenate. got7fsn_ti Reactome:R-HSA-2408525 molecular_function owl:Class
GO:0036218 biolink:NamedThing dTTP diphosphatase activity Catalysis of the reaction: dTTP + H2O = dTMP + diphosphate. got7fsn_ti bf 2012-05-08T01:47:59Z EC:3.6.1.9|RHEA:28534|MetaCyc:RXN0-5107 molecular_function owl:Class
GO:0036386 biolink:NamedThing bacterial nucleoid DNA packaging Compaction of DNA in a bacterial nucleoid into a compact structure. Often achieved by DNA supercoiling. got7fsn_ti prokaryotic DNA condensation|nucleoid compaction|chromosomal compaction bf 2013-05-30T10:41:08Z biological_process owl:Class
GO:0035861 biolink:NamedThing site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. got7fsn_ti IRIF|DNA damage focus|ionizing radiation-induced foci|site of DSB|DNA damage foci bf 2011-05-17T03:04:42Z cellular_component owl:Class
GO:0043826 biolink:NamedThing sulfur oxygenase reductase activity Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+. got7fsn_ti sulphur oxygenase reductase activity|SOR MetaCyc:RXN-8226 molecular_function owl:Class
GO:0072701 biolink:NamedThing cellular response to bismuth Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus. got7fsn_ti cellular response to bismuth ion mah 2012-04-11T02:56:42Z biological_process owl:Class
GO:0030760 biolink:NamedThing pyridine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine. got7fsn_ti pyridine methyltransferase activity|S-adenosyl-L-methionine:pyridine N-methyltransferase activity KEGG_REACTION:R02862|EC:2.1.1.87|MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN|Reactome:R-HSA-175987|RHEA:16893 molecular_function owl:Class
GO:0047113 biolink:NamedThing aldehyde dehydrogenase (quinone) activity Catalysis of the reaction: an aldehyde + a quinone + H2O = a carboxylate + a quinol. got7fsn_ti aldehyde:(pyrroloquinoline-quinone) oxidoreductase activity|aldehyde dehydrogenase (acceptor) activity|aldehyde dehydrogenase (pyrroloquinoline-quinone) MetaCyc:1.2.99.3-RXN|RHEA:13881|EC:1.2.5.2 molecular_function owl:Class
GO:0098982 biolink:NamedThing GABA-ergic synapse A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. got7fsn_ti cellular_component owl:Class
GO:0070214 biolink:NamedThing CSK-GAP-A.p62 complex A protein complex that contains the protein-tyrosine kinase CSK and the GTPase-activating protein (GAP)-associated p62 (GAP-A.p62); may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation. got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0044536 biolink:NamedThing envenomation resulting in depletion of circulating fibrinogen in other organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism. got7fsn_ti envenomation resulting in negative regulation of circulating fibrinogen in other organism jl 2012-03-21T02:56:49Z biological_process owl:Class
GO:0003176 biolink:NamedThing aortic valve development The progression of the aortic valve over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-08T11:18:55Z biological_process owl:Class
GO:0102045 biolink:NamedThing 3-chlorobenzoate-3,4-oxygenase activity Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-10422 molecular_function owl:Class
GO:0050086 biolink:NamedThing mannitol 2-dehydrogenase activity Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH. got7fsn_ti D-mannitol dehydrogenase activity|D-mannitol:NAD+ 2-oxidoreductase activity MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN|EC:1.1.1.67|RHEA:12084 molecular_function owl:Class
GO:0061275 biolink:NamedThing mesonephric proximal tubule development The progression of the mesonephric proximal tubule over time, from its formation to the mature structure. The mesonephric proximal tubule extends from the capsule to the distal tubule. got7fsn_ti dph 2010-09-02T01:08:05Z biological_process owl:Class
GO:0071203 biolink:NamedThing WASH complex A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. got7fsn_ti mah 2009-11-25T11:01:33Z cellular_component owl:Class
GO:0102910 biolink:NamedThing dirigent protein activity Catalysis of the reaction: 2 H+ + 2 coniferol + O2 <=> (+)-pinoresinol + 2 H2O. got7fsn_ti MetaCyc:RXN-8677 molecular_function owl:Class
GO:0008140 biolink:NamedThing cAMP response element binding protein binding Binding to a cAMP response element binding protein (a CREB protein). got7fsn_ti 3',5' cAMP response element binding protein binding|adenosine 3',5'-cyclophosphate response element binding protein binding|cyclic AMP response element binding protein binding|CREB binding|3',5'-cAMP response element binding protein binding|CBP molecular_function owl:Class
GO:0102411 biolink:NamedThing quercetin-3,4'-O-glucosyltransferase activity Catalysis of the reaction: quercetin-3-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-). got7fsn_ti MetaCyc:RXN-13766 molecular_function owl:Class
GO:0016254 biolink:NamedThing preassembly of GPI anchor in ER membrane The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane. got7fsn_ti preassembly of GPI anchor in endoplasmic reticulum membrane biological_process owl:Class
GO:0006650 biolink:NamedThing glycerophospholipid metabolic process The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue. got7fsn_ti phosphoglyceride metabolism|alpha-glycerophosphate pathway|phosphoglyceride metabolic process|glycerophospholipid metabolism GO:0006652 biological_process owl:Class
GO:0047409 biolink:NamedThing alkenylglycerophosphoethanolamine hydrolase activity Catalysis of the reaction: H2O + 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine = sn-glycero-3-phosphoethanolamine + an aldehyde. got7fsn_ti 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity RHEA:16905|EC:3.3.2.5|MetaCyc:3.3.2.5-RXN molecular_function owl:Class
GO:0019806 biolink:NamedThing bromide peroxidase activity Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide. got7fsn_ti bromoperoxidase activity EC:1.11.1.18 molecular_function owl:Class
GO:0099525 biolink:NamedThing presynaptic dense core vesicle exocytosis The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels. got7fsn_ti biological_process owl:Class
GO:0001608 biolink:NamedThing G protein-coupled nucleotide receptor activity Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti nucleotide receptor activity, G-protein coupled|nucleotide receptor activity, G protein coupled|G protein coupled nucleotide receptor activity|G-protein coupled nucleotide receptor activity molecular_function owl:Class
GO:0004493 biolink:NamedThing methylmalonyl-CoA epimerase activity Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA. got7fsn_ti methylmalonyl-CoA racemase activity|methylmalonyl-CoA 2-epimerase activity|2-methyl-3-oxopropanoyl-CoA 2-epimerase activity|methylmalonyl coenzyme A racemase activity|DL-methylmalonyl-CoA racemase activity RHEA:20553|MetaCyc:METHYLMALONYL-COA-EPIM-RXN|Reactome:R-HSA-71020|KEGG_REACTION:R02765|EC:5.1.99.1 molecular_function owl:Class
GO:0030240 biolink:NamedThing skeletal muscle thin filament assembly The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle. got7fsn_ti biological_process owl:Class
GO:0090683 biolink:NamedThing GPCR sweet taste receptor activity A G protein-coupled receptor activity that is responsible for the sense of sweet taste. got7fsn_ti G-protein coupled receptor sweet taste receptor activity tb 2016-05-20T15:49:18Z molecular_function owl:Class
GO:0102917 biolink:NamedThing (S)-reticuline 7-O-methyltransferase activity Catalysis of the reaction: (S)-reticulinium(1+) + S-adenosyl-L-methionine <=> H+ + laudanine(1+) + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:10444|EC:2.1.1.291|MetaCyc:RXN-8700 molecular_function owl:Class
GO:0052798 biolink:NamedThing beta-galactoside alpha-2,3-sialyltransferase activity Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor. got7fsn_ti trans-sialidase activity molecular_function owl:Class
GO:0043406 biolink:NamedThing positive regulation of MAP kinase activity Any process that activates or increases the frequency, rate or extent of MAP kinase activity. got7fsn_ti upregulation of MAPK activity|positive regulation of mitogen-activated protein kinase activity|positive regulation of mitogen activated protein kinase activity|up-regulation of MAPK activity|up regulation of MAPK activity|stimulation of MAPK activity biological_process owl:Class
GO:0048258 biolink:NamedThing 3-ketoglucose-reductase activity Catalysis of the reaction: NADP+ + 3-dehydro-alpha-D-glucose = NADPH + alpha-D-glucose. got7fsn_ti MetaCyc:KETOGLUCOSE-REDUCTASE-RXN molecular_function owl:Class
GO:0043824 biolink:NamedThing succinylglutamate-semialdehyde dehydrogenase activity Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H(2)O + NAD(+) = N-succinyl-L-glutamate + 2 H(+) + NADH. got7fsn_ti N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase activity|AruD|N-succinylglutamate 5-semialdehyde dehydrogenase activity|succinyl glutamate-semialdehyde dehydrogenase activity|AstD|SGSD|succinylglutamic semialdehyde dehydrogenase activity RHEA:10812|EC:1.2.1.71|KEGG_REACTION:R05049|MetaCyc:SUCCGLUALDDEHYD-RXN molecular_function owl:Class
GO:0033066 biolink:NamedThing Rad51B-Rad51C complex A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof. got7fsn_ti BC complex cellular_component owl:Class
GO:0072651 biolink:NamedThing interferon-tau production The appearance of interferon-tau due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IFN-tau secretion|IFN-tau production|interferon-tau secretion|IFNT production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072652 biological_process owl:Class
GO:0102470 biolink:NamedThing 6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity Catalysis of the reaction: 2,4,4',6-tetrahydroxydibenzoylmethane + UDP-alpha-D-glucose <=> 6C-glucosyl-2-hydroxynaringenin + UDP + H+. got7fsn_ti MetaCyc:RXN-14075 molecular_function owl:Class
GO:0032364 biolink:NamedThing oxygen homeostasis A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell. got7fsn_ti biological_process owl:Class
GO:0009012 biolink:NamedThing aminoglycoside 3''-adenylyltransferase activity Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H(+). got7fsn_ti streptomycin 3''-adenylyltransferase activity|ATP:streptomycin 3''-adenylyltransferase activity|AAD (3'') KEGG_REACTION:R02226|EC:2.7.7.47|RHEA:20245|MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN molecular_function owl:Class
GO:0034871 biolink:NamedThing 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1308 molecular_function owl:Class
GO:0097163 biolink:NamedThing sulfur carrier activity Covalently binding to sulfur and delivering it to an acceptor molecule. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14455 pr 2011-09-27T10:15:41Z molecular_function owl:Class
GO:0140104 biolink:NamedThing molecular carrier activity Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. got7fsn_ti https://github.com/geneontology/go-ontology/issues/14221|https://github.com/geneontology/go-ontology/issues/20848 Note that a carrier moves with its substrate/cargo, while a transporter does not move with the cargo, but facilitates the change in localization. pg 2017-09-19T13:10:18Z molecular_function owl:Class
GO:0099592 biolink:NamedThing endocytosed synaptic vesicle processing via endosome The process in which endocytosed synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. got7fsn_ti synaptic vesicle processing via endosome involved in synaptic vesicle recycling biological_process owl:Class
GO:0043959 biolink:NamedThing L-erythro-3-methylmalyl-CoA lyase activity Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA. got7fsn_ti HpcH/HpaI aldolase EC:4.1.3.24 molecular_function owl:Class
GO:0010767 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus. got7fsn_ti biological_process owl:Class
GO:0036461 biolink:NamedThing BLOC-2 complex binding Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. got7fsn_ti bf 2014-06-11T09:14:55Z molecular_function owl:Class
GO:0009016 biolink:NamedThing succinyldiaminopimelate transaminase activity Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate. got7fsn_ti N-succinyl-L-diaminopimelic glutamic transaminase activity|N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity|succinyldiaminopimelate aminotransferase activity|succinyldiaminopimelate transferase activity MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN|RHEA:11960|EC:2.6.1.17|KEGG_REACTION:R04475 molecular_function owl:Class
GO:0008486 biolink:NamedThing diphosphoinositol-polyphosphate diphosphatase activity Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate. got7fsn_ti diphosphoinositol-polyphosphate phosphohydrolase activity|DIPP activity|diphosphoinositol polyphosphate phosphohydrolase activity|diphospho-myo-inositol-polyphosphate diphosphohydrolase activity EC:3.6.1.52|MetaCyc:3.6.1.52-RXN|KEGG_REACTION:R05777 molecular_function owl:Class
GO:0033436 biolink:NamedThing AUG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AUG codon. got7fsn_ti ATG codon-amino acid adaptor activity|initiator methionine tRNA|methionine tRNA Note that in the standard genetic code, ATG codes for methionine, and is the initiator codon. molecular_function owl:Class
GO:0051131 biolink:NamedThing chaperone-mediated protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. got7fsn_ti protein complex assembly, multichaperone pathway|cellular chaperone-mediated protein complex assembly|chaperone activity GO:0034619 biological_process owl:Class
GO:0009361 biolink:NamedThing succinate-CoA ligase complex (ADP-forming) A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP. got7fsn_ti succinyl-CoA synthetase, ADP-forming cellular_component owl:Class
GO:0106257 biolink:NamedThing glycerol-3-phosphate dehydrogenase [NADP+] activity Catalysis of the reaction: sn-glycerol 3-phosphate + NADP+ = glycerone phosphate + NADH + H+. got7fsn_ti hjd 2020-04-03T17:10:44Z RHEA:11096 molecular_function owl:Class
GO:0071984 biolink:NamedThing maintenance of reproductive diapause The dormancy process that results an organism remaining in reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli. got7fsn_ti mah 2010-10-21T04:49:28Z biological_process owl:Class
GO:0034877 biolink:NamedThing isonicotinate dehydrogenase activity Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor. got7fsn_ti UM-BBD_reactionID:r1337 molecular_function owl:Class
GO:0039017 biolink:NamedThing pattern specification involved in pronephros development Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate. got7fsn_ti pattern specification involved in pronephric kidney development bf 2010-07-02T10:04:39Z biological_process owl:Class
GO:0033956 biolink:NamedThing beta-apiosyl-beta-glucosidase activity Catalysis of the reaction: 7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid + H2O = a 7-hydroxyisoflavonoid + beta-D-apiofuranosyl-(1->6)-D-glucose. got7fsn_ti isoflavonoid 7-O-beta-apiosyl-glucoside beta-glucosidase activity|isoflavonoid-7-O-beta[D-apiosyl-(1->6)-beta-D-glucoside] disaccharidase activity|7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity|furcatin hydrolase activity MetaCyc:RXN-9156|RHEA:21488|MetaCyc:3.2.1.161-RXN|EC:3.2.1.161 molecular_function owl:Class
GO:0044835 biolink:NamedThing hydrogen generation via nitrogenase The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria. got7fsn_ti jl 2014-02-19T14:59:15Z biological_process owl:Class
GO:0102904 biolink:NamedThing germacrene C synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = germacrene C + diphosphoric acid. got7fsn_ti EC:4.2.3.60|MetaCyc:RXN-8561|RHEA:28302 molecular_function owl:Class
GO:0004726 biolink:NamedThing non-membrane spanning protein tyrosine phosphatase activity Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. got7fsn_ti Reactome:R-HSA-177924|Reactome:R-HSA-177923|Reactome:R-HSA-9635739|Reactome:R-HSA-177935|Reactome:R-HSA-177926 molecular_function owl:Class
GO:0102886 biolink:NamedThing alpha-chamigrene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> alpha-chamigrene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8428 molecular_function owl:Class
GO:0048843 biolink:NamedThing negative regulation of axon extension involved in axon guidance Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. got7fsn_ti inhibition of axon extension involved in axon guidance|down-regulation of axon extension involved in axon guidance|down regulation of axon extension involved in axon guidance|downregulation of axon extension involved in axon guidance biological_process owl:Class
GO:0044515 biolink:NamedThing envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism. got7fsn_ti jl 2012-02-26T11:08:08Z biological_process owl:Class
GO:0071761 biolink:NamedThing IgZ immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgZ isotype and two identical immunoglobulin light chains, held together by disulfide bonds. The IgZ isotype is also known as the IgT isotype in certain species of fish. got7fsn_ti IgT immunoglobulin complex|IgT antibody|IgZ antibody Note that an IgZ immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgZ is found in bony fish, and called IgT in certain species, such as trout. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0033834 biolink:NamedThing kaempferol 3-O-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + kaempferol = UDP + kaempferol 3-O-beta-D-galactoside. got7fsn_ti F3GalTase activity|UDP-galactose:kaempferol 3-O-beta-D-galactosyltransferase activity MetaCyc:2.4.1.234-RXN|EC:2.4.1.234|RHEA:15709 molecular_function owl:Class
GO:0018531 biolink:NamedThing (S)-6-hydroxynicotine oxidase activity Catalysis of the reaction: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2). got7fsn_ti (S)-6-hydroxynicotine:oxygen oxidoreductase activity|6-hydroxy-L-nicotine:oxygen oxidoreductase activity|6-hydroxy-L-nicotine oxidase activity|L-6-hydroxynicotine oxidase activity UM-BBD_reactionID:r0478|RHEA:11880|EC:1.5.3.5|KEGG_REACTION:R03202|MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN molecular_function owl:Class
GO:0072582 biolink:NamedThing 17-beta-hydroxysteroid dehydrogenase (NADP+) activity Catalysis of the reaction: a 17-beta-hydroxysteroid + NADP+ = a 17-oxosteroid + NADPH + H+. got7fsn_ti mah 2011-02-07T01:54:21Z RHEA:24616 molecular_function owl:Class
GO:0075053 biolink:NamedThing penetration peg formation The assembly by the symbiont of a peg-like structure for the purpose of penetration into its host organism, which penetrates through the host cuticle and epidermal cell wall. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti symbiont penetration peg initiation|initiation of symbiont penetration peg|symbiont penetration peg formation for entry into host|formation of symbiont penetration peg for entry into host https://github.com/geneontology/go-ontology/issues/18557 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. GO:0075057 biological_process owl:Class
GO:0102190 biolink:NamedThing 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) <=> 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O. got7fsn_ti MetaCyc:RXN-11958 molecular_function owl:Class
GO:0035544 biolink:NamedThing negative regulation of SNARE complex assembly Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. got7fsn_ti bf 2010-05-10T01:51:10Z biological_process owl:Class
GO:0034586 biolink:NamedThing 21U-RNA catabolic process The chemical reactions and pathways resulting in the breakdown of 21U-RNAs, a class of single-stranded RNA molecules of about 21 nucleotides in length characterized by a uridine 5'-monophosphate and a modified 3' end resistant to periodate degradation. 21U-RNAs are derived from distinct, autonomously expressed loci within the genome. got7fsn_ti 21U-RNA catabolism|21U-RNA breakdown|21U-RNA degradation biological_process owl:Class
GO:0016205 biolink:NamedThing selenocysteine methyltransferase activity Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine. got7fsn_ti RHEA:26341|MetaCyc:RXN-11061|EC:2.1.1.280 molecular_function owl:Class
GO:0033828 biolink:NamedThing glucosylglycerol-phosphate synthase activity Catalysis of the reaction: sn-glycerol 3-phosphate + ADP-glucose = 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + ADP + H(+). got7fsn_ti ADP-glucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity|ADPglucose:sn-glycerol-3-phosphate 2-beta-D-glucosyltransferase activity|GG-phosphate synthase activity|glucosyl-glycerol-phosphate synthase activity|GGPS RHEA:12881|KEGG_REACTION:R05328|MetaCyc:2.4.1.213-RXN|EC:2.4.1.213 molecular_function owl:Class
GO:0010190 biolink:NamedThing cytochrome b6f complex assembly Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents. got7fsn_ti cytochrome b6f complex biogenesis biological_process owl:Class
GO:0006597 biolink:NamedThing spermine biosynthetic process The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. got7fsn_ti spermine formation|spermine biosynthesis|spermine synthesis|spermine anabolism biological_process owl:Class
GO:0048312 biolink:NamedThing intracellular distribution of mitochondria Any process that establishes the spatial arrangement of mitochondria within the cell. got7fsn_ti mitochondria positioning within cell|mitochondrion positioning within cell biological_process owl:Class
GO:0031055 biolink:NamedThing chromatin remodeling at centromere Dynamic structural changes in centromeric DNA. got7fsn_ti biological_process owl:Class
GO:0052693 biolink:NamedThing epoxyqueuosine reductase activity Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant. got7fsn_ti RHEA:32159|EC:1.17.99.6 molecular_function owl:Class
GO:0062184 biolink:NamedThing testosterone 16-beta-hydroxylase activity Catalysis of the reaction: O2 + reduced [NADPH--hemoprotein reductase] + testosterone = 16beta,17beta-dihydroxyandrost-4-en-3-one + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti dph 2019-11-26T18:43:43Z RHEA:46304 molecular_function owl:Class
GO:1990489 biolink:NamedThing anaerobic pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen. got7fsn_ti anaerobic pectin degradation tt 2014-09-20T18:09:53Z biological_process owl:Class
GO:0045490 biolink:NamedThing pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. got7fsn_ti pectin degradation|pectin catabolism|pectin breakdown biological_process owl:Class
GO:0010378 biolink:NamedThing temperature compensation of the circadian clock The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms. got7fsn_ti regulation of the circadian clock by temperature biological_process owl:Class
GO:0010356 biolink:NamedThing homogentisate geranylgeranyltransferase activity Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol. got7fsn_ti molecular_function owl:Class
GO:0060038 biolink:NamedThing cardiac muscle cell proliferation The expansion of a cardiac muscle cell population by cell division. got7fsn_ti heart muscle cell proliferation|cardiomyocyte proliferation|cardiac myocyte proliferation biological_process owl:Class
GO:0052595 biolink:NamedThing aliphatic-amine oxidase activity Catalysis of the reaction: an aliphatic amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide + H+. got7fsn_ti aliphatic-amine:oxygen oxidoreductase(deaminating) activity EC:1.4.3.21|MetaCyc:AMINEOXID-RXN|RHEA:16153 molecular_function owl:Class
GO:2000750 biolink:NamedThing negative regulation of establishment or maintenance of bipolar cell polarity regulating cell shape Any process that stops, prevents or reduces the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape. got7fsn_ti mah 2011-06-16T11:51:49Z biological_process owl:Class
GO:0005372 biolink:NamedThing water transmembrane transporter activity Enables the transfer of water (H2O) from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0044547 biolink:NamedThing DNA topoisomerase binding Binding to a DNA topoisomerase. got7fsn_ti DNA topoisomerase I binding jl 2012-03-22T02:30:37Z GO:0017033 molecular_function owl:Class
GO:0061828 biolink:NamedThing apical tubulobulbar complex Actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell. got7fsn_ti apical TBC dph 2017-01-15T10:41:00Z cellular_component owl:Class
GO:0047808 biolink:NamedThing D(-)-tartrate dehydratase activity Catalysis of the reaction: D-tartrate = H(2)O + oxaloacetate. got7fsn_ti D-tartrate dehydratase activity|(S,S)-tartrate hydro-lyase activity|(S,S)-tartrate hydro-lyase (oxaloacetate-forming) MetaCyc:D--TARTRATE-DEHYDRATASE-RXN|RHEA:18289|KEGG_REACTION:R00340|EC:4.2.1.81 molecular_function owl:Class
GO:0102143 biolink:NamedThing carboxynorspermidine dehydrogenase I activity Catalysis of the reaction: carboxynorspermidine + NADP + H2O <=> L-aspartic acid 4-semialdehyde betaine + trimethylenediaminium + NADPH + H+. got7fsn_ti RHEA:34115|MetaCyc:RXN-11565 molecular_function owl:Class
GO:1990491 biolink:NamedThing methane biosynthetic process from methanol and hydrogen The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen. got7fsn_ti methanogenesis from methanol and hydrogen|methane biosynthesis from methanol and hydrogen tt 2014-09-21T01:08:40Z biological_process owl:Class
GO:0018851 biolink:NamedThing alpha-pinene-oxide decyclase activity Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal. got7fsn_ti alpha-pinene-oxide lyase (decyclizing)|alpha-pinene oxide lyase activity UM-BBD_reactionID:r0743|MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN|RHEA:16693|KEGG_REACTION:R04040|EC:5.5.1.10 molecular_function owl:Class
GO:0050682 biolink:NamedThing AF-2 domain binding Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation. got7fsn_ti molecular_function owl:Class
GO:0051587 biolink:NamedThing inhibition of dopamine uptake involved in synaptic transmission Any process that prevents the activation of the directed movement of dopamine into a cell. got7fsn_ti inhibition of dopamine import involved in synaptic transmission biological_process owl:Class
GO:0051585 biolink:NamedThing negative regulation of dopamine uptake involved in synaptic transmission Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell. got7fsn_ti down regulation of dopamine uptake involved in synaptic transmission|negative regulation of dopamine import involved in synaptic transmission|down-regulation of dopamine uptake involved in synaptic transmission|downregulation of dopamine uptake involved in synaptic transmission biological_process owl:Class
GO:0086008 biolink:NamedThing voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti tb 2011-11-10T08:38:09Z molecular_function owl:Class
GO:0018267 biolink:NamedThing GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine|GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine RESID:AA0160 biological_process owl:Class
GO:0042250 biolink:NamedThing maintenance of polarity of embryonic epithelium The maintenance of an established polarized embryonic epithelial sheet. got7fsn_ti biological_process owl:Class
GO:0039686 biolink:NamedThing bidirectional double-stranded viral DNA replication A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions. got7fsn_ti viral bidirectional dsDNA replication bf 2013-10-17T14:42:09Z VZ:1939 biological_process owl:Class
GO:0099016 biolink:NamedThing DNA end degradation evasion by virus Any process, either active or passive, by which a virus evades and ends degradation of its DNA when free viral-DNA ends are exposed as part of its life-cycle. For example, some bacteriophages encode proteins that bind to free viral DNA ends, protecting them from degradation by host exonucleases. got7fsn_ti VZ:3963 biological_process owl:Class
GO:0008761 biolink:NamedThing UDP-N-acetylglucosamine 2-epimerase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine. got7fsn_ti UDP-N-acetyl-D-glucosamine 2-epimerase activity|UDP-N-acetylglucosamine 2'-epimerase activity|uridine diphosphoacetylglucosamine 2'-epimerase activity|uridine diphospho-N-acetylglucosamine 2'-epimerase activity|UDP-GlcNAc-2-epimerase activity|uridine diphosphate-N-acetylglucosamine-2'-epimerase activity MetaCyc:UDPGLCNACEPIM-RXN|EC:5.1.3.14|RHEA:17213|Reactome:R-HSA-4085021|Reactome:R-HSA-4088338 molecular_function owl:Class
GO:1990194 biolink:NamedThing cytoplasmic U snRNP body assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body. got7fsn_ti U body assembly tb 2013-09-12T21:54:20Z biological_process owl:Class
GO:0102205 biolink:NamedThing cholesterol alpha-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+. got7fsn_ti cholesterol UDP-glucosyltransferase activity|cholesterol allpha-glucosyltransferase activity GO:0051505 MetaCyc:RXN-12127|EC:2.4.1.173|RHEA:61848 molecular_function owl:Class
GO:0101014 biolink:NamedThing [isocitrate dehydrogenase (NADP+)] phosphatase activity Catalysis of the reaction: [isocitrate dehydrogenase] phosphate + H2O = [isocitrate dehydrogenase] + phosphate. got7fsn_ti isocitrate dehydrogenase kinase/phosphatase activity MetaCyc:ICITDEHASE-KIN-PHOSPHA molecular_function owl:Class
GO:0031425 biolink:NamedThing chloroplast RNA processing The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules. got7fsn_ti biological_process owl:Class
GO:0071831 biolink:NamedThing intermediate-density lipoprotein particle clearance The process in which a intermediate-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. got7fsn_ti IDL clearance mah 2010-09-08T11:26:12Z biological_process owl:Class
GO:0043474 biolink:NamedThing pigment metabolic process involved in pigmentation The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell. got7fsn_ti pigment metabolism during pigmentation|pigment metabolic process during pigmentation biological_process owl:Class
GO:0051583 biolink:NamedThing dopamine uptake involved in synaptic transmission The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. got7fsn_ti dopamine reuptake involved in synaptic transmission|dopamine import involved in synaptic transmission biological_process owl:Class
GO:0047126 biolink:NamedThing N5-(carboxyethyl)ornithine synthase activity Catalysis of the reaction: N(5)-[1(S)-1-carboxyethyl]-L-ornithine + H(2)O + NADP(+) = L-ornithine + H(+) + NADPH + pyruvate. got7fsn_ti N5-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming)|5-N-(L-1-carboxyethyl)-L-ornithine:NADP+ oxidoreductase (L-ornithine-forming) KEGG_REACTION:R00666|EC:1.5.1.24|MetaCyc:1.5.1.24-RXN|RHEA:18661 molecular_function owl:Class
GO:0033368 biolink:NamedThing protease localization to mast cell secretory granule Any process in which a protease is transported to, or maintained in, a location within a secretory granule in a mast cell. got7fsn_ti protease localization in mast cell secretory granule|protease localisation in mast cell secretory granule biological_process owl:Class
GO:0042796 biolink:NamedThing snRNA transcription by RNA polymerase III The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter. got7fsn_ti snRNA transcription from Pol III promoter|snRNA transcription from RNA polymerase III promoter https://github.com/geneontology/go-ontology/issues/14854 biological_process owl:Class
GO:0097150 biolink:NamedThing neuronal stem cell population maintenance Any process in by an organism or tissue maintains a population of neuronal stem cells. got7fsn_ti pr 2011-08-04T11:18:28Z biological_process owl:Class
GO:0036174 biolink:NamedThing butane monooxygenase activity Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O. got7fsn_ti sBMO|soluble butane monooxygenase bf 2012-03-29T10:42:07Z molecular_function owl:Class
GO:0097138 biolink:NamedThing BAD-BCL-2 complex A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:37:50Z cellular_component owl:Class
GO:2000213 biolink:NamedThing positive regulation of glutamate metabolic process Any process that activates or increases the frequency, rate or extent of glutamate metabolic process. got7fsn_ti positive regulation of glutamic acid metabolic process|positive regulation of glutamate metabolism|positive regulation of glutamic acid metabolism mah 2010-11-03T02:43:59Z biological_process owl:Class
GO:0102874 biolink:NamedThing 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-16:0-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-16:0-2-18:3-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.35|MetaCyc:RXN-8365 molecular_function owl:Class
GO:0050191 biolink:NamedThing phosphoglycerate kinase (GTP) activity Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H(+). got7fsn_ti GTP:3-phospho-D-glycerate 1-phosphotransferase activity MetaCyc:PHOSPHOGLYCERATE-KINASE-GTP-RXN|RHEA:23332|EC:2.7.2.10|KEGG_REACTION:R01517 molecular_function owl:Class
GO:0106381 biolink:NamedThing purine deoxyribonucleotide salvage Any process which produces a purine deoxyribonucleotide from derivatives of it, without de novo synthesis. got7fsn_ti hjd 2021-06-11T14:55:33Z biological_process owl:Class
GO:0036337 biolink:NamedThing Fas signaling pathway A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily. got7fsn_ti Apo-1 signaling pathway|Fas receptor signaling pathway|CD95 signaling pathway|FAS ligand-Fas signaling pathway|Fas-FasL signaling pathway|FasR signaling pathway|FasL signaling pathway bf 2012-09-05T10:28:11Z biological_process owl:Class
GO:0060791 biolink:NamedThing sebaceous gland placode formation The developmental process in which a sebaceous gland placode forms. A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud. got7fsn_ti dph 2009-08-04T12:23:09Z biological_process owl:Class
GO:0061610 biolink:NamedThing glycerol to glycerone phosphate metabolic process The chemical reactions and pathways in which glycerol, 1,2,3-propanetriol, is converted to glycerone phosphate. got7fsn_ti glycerol metabolism to DHAP|glycerol to dihydroxyacetone phosphate metabolic process|glycerol metabolism to glycerone phosphate|glycerol metabolism to dihydroxyacetone phosphate|glycerol to DHAP metabolic process dph 2014-04-03T13:26:21Z biological_process owl:Class
GO:0006071 biolink:NamedThing glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. got7fsn_ti glycerol metabolism MetaCyc:GLYCEROLMETAB-PWY biological_process owl:Class
GO:0052422 biolink:NamedThing modulation by host of symbiont catalytic activity The process in which a host organism effects a change in the enzyme activity of its symbiont organism. got7fsn_ti modulation by host of symbiont enzyme activity|modulation by host of symbiont molecular function GO:0052428 biological_process owl:Class
GO:0003986 biolink:NamedThing acetyl-CoA hydrolase activity Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+). got7fsn_ti acetyl-CoA acylase activity|acetyl coenzyme A acylase activity|acetyl-CoA deacylase activity|acetyl coenzyme A hydrolase activity|acetyl coenzyme A deacylase activity|acetyl-CoA thiol esterase activity RHEA:20289|Reactome:R-HSA-390304|KEGG_REACTION:R00227|Reactome:R-HSA-2066779|MetaCyc:ACETYL-COA-HYDROLASE-RXN|EC:3.1.2.1 molecular_function owl:Class
GO:0110147 biolink:NamedThing protein maturation by nickel ion transfer A process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation. got7fsn_ti kmv 2019-05-31T14:41:20Z biological_process owl:Class
GO:0047234 biolink:NamedThing raffinose-raffinose alpha-galactotransferase activity Catalysis of the reaction: 2 raffinose = sucrose + 1F-alpha-D-galactosylraffinose. got7fsn_ti raffinose-raffinose a-galactosyltransferase activity|raffinose-raffinose alpha-galactosyltransferase activity|raffinose:raffinose alpha-D-galactosyltransferase activity|raffinose (raffinose donor) galactosyltransferase activity|raffinose:raffinose alpha-galactosyltransferase activity MetaCyc:2.4.1.166-RXN|RHEA:14125|EC:2.4.1.166 molecular_function owl:Class
GO:0031861 biolink:NamedThing prolactin-releasing peptide receptor binding Binding to a prolactin-releasing peptide receptor. got7fsn_ti prolactin-releasing peptide receptor ligand molecular_function owl:Class
GO:0032198 biolink:NamedThing MITE transposition Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs). got7fsn_ti Class III transposition biological_process owl:Class
GO:0051190 biolink:NamedThing prosthetic group catabolic process The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein. got7fsn_ti prosthetic group catabolism|prosthetic group degradation|coenzyme and prosthetic group catabolic process|coenzyme and prosthetic group catabolism|prosthetic group breakdown biological_process owl:Class
GO:0007223 biolink:NamedThing Wnt signaling pathway, calcium modulating pathway The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC). got7fsn_ti non-canonical Wnt signaling pathway|Wnt-activated signaling pathway, calcium modulating pathway|frizzled-2 signalling pathway|frizzled-2 signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway biological_process owl:Class
GO:0042988 biolink:NamedThing X11-like protein binding Binding to X11-like protein, a neuron-specific adaptor protein. got7fsn_ti X11L binding molecular_function owl:Class
GO:0102336 biolink:NamedThing 3-oxo-arachidoyl-CoA synthase activity Catalysis of the reaction: stearoyl-CoA(4-) + malonyl-CoA(5-) + H+ <=> 3-oxoicosanoyl-CoA. + carbon dioxide + coenzyme A. got7fsn_ti MetaCyc:RXN-13294|RHEA:35319 molecular_function owl:Class
GO:0010032 biolink:NamedThing meiotic chromosome condensation Compaction of chromatin structure prior to meiosis in eukaryotic cells. got7fsn_ti chromosome condensation involved in meiotic cell cycle biological_process owl:Class
GO:0060649 biolink:NamedThing mammary gland bud elongation The process in which the mammary gland bud grows along its axis. got7fsn_ti dph 2009-05-29T08:50:39Z biological_process owl:Class
GO:0019363 biolink:NamedThing pyridine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. got7fsn_ti pyridine nucleotide formation|pyridine nucleotide biosynthesis|pyridine nucleotide synthesis|pyridine nucleotide anabolism MetaCyc:PYRIDNUCSYN-PWY biological_process owl:Class
GO:0035824 biolink:NamedThing long tract gene conversion A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor. got7fsn_ti bf 2011-05-04T01:06:18Z biological_process owl:Class
GO:0061468 biolink:NamedThing karyomere A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division. got7fsn_ti dph 2012-10-22T14:19:29Z cellular_component owl:Class
GO:0061611 biolink:NamedThing mannose to fructose-6-phosphate metabolic process The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate. got7fsn_ti mannose metabolism to fructose-6-phosphate dph 2014-04-03T13:38:50Z biological_process owl:Class
GO:0006013 biolink:NamedThing mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. got7fsn_ti mannose metabolism biological_process owl:Class
GO:0140020 biolink:NamedThing DNA methyltransferase complex A protein complex that possesses DNA methyltransferase activity. got7fsn_ti pg 2017-04-06T19:12:09Z cellular_component owl:Class
GO:0031881 biolink:NamedThing type 4 somatostatin receptor binding Binding to a type 4 somatostatin receptor. got7fsn_ti type 4 somatostatin receptor ligand molecular_function owl:Class
GO:0005427 biolink:NamedThing proton-dependent oligopeptide secondary active transmembrane transporter activity Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement. got7fsn_ti hydrogen/oligopeptide symporter|proton-dependent oligopeptide transporter activity molecular_function owl:Class
GO:0018723 biolink:NamedThing 3-phenanthrol sulfotransferase activity Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate. got7fsn_ti 3-phenanthrol sulphotransferase activity UM-BBD_reactionID:r0561 molecular_function owl:Class
GO:0140533 biolink:NamedThing suppression of host RNAi-mediated antiviral immune response Any process in which a symbiont stops, prevents, or reduces the rate or extent of the host's RNAi-mediated antiviral immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti suppression of host RNAi-mediated gene silencing|suppression of host RNAi-mediated antiviral immunity https://github.com/geneontology/go-ontology/issues/19958 pg 2020-10-28T07:55:27Z biological_process owl:Class
GO:0001502 biolink:NamedThing cartilage condensation The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. got7fsn_ti biological_process owl:Class
GO:0034555 biolink:NamedThing 3,3'-dibromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3,3'-dibromobisphenol A + 2 H+ + 2 e- = 3-monobromobisphenol A + HBr. got7fsn_ti UM-BBD_reactionID:r0844|EC:1.97.1.- molecular_function owl:Class
GO:0047223 biolink:NamedThing beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R + UDP. got7fsn_ti elongation 3-beta-GalNAc-transferase activity|O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity|UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to -D-galactose of beta-D-galactosyl-1,3-(N-acetyl-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity|uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase (elongating)|elongation 3beta-GalNAc-transferase activity MetaCyc:2.4.1.146-RXN|Reactome:R-HSA-5617096|Reactome:R-HSA-5617037|EC:2.4.1.146 molecular_function owl:Class
GO:0042744 biolink:NamedThing hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). got7fsn_ti hydrogen peroxide scavenging|detoxification of H2O2|hydrogen peroxide catabolism|hydrogen peroxide removal|hydrogen peroxide degradation|H2O2 catabolic process|detoxification of hydrogen peroxide|hydrogen peroxide breakdown|H2O2 scavenging biological_process owl:Class
GO:0018831 biolink:NamedThing 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone. got7fsn_ti EC:4.5.1.-|UM-BBD_reactionID:r0666 molecular_function owl:Class
GO:0051116 biolink:NamedThing cobaltochelatase activity Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate. got7fsn_ti CobNST|hydrogenobyrinic acid a,c-diamide cobaltochelatase activity|hydrogenobyrinic-acid-a,c-diamide:cobalt cobalt-ligase (ADP-forming)|CobN-CobST EC:6.6.1.2|KEGG_REACTION:R05227|MetaCyc:R342-RXN|RHEA:15341 molecular_function owl:Class
GO:0048921 biolink:NamedThing posterior lateral line neuromast cupula development The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter. got7fsn_ti biological_process owl:Class
GO:0098613 biolink:NamedThing methaneselenol methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide. got7fsn_ti Reactome:R-HSA-2408541 molecular_function owl:Class
GO:0006690 biolink:NamedThing icosanoid metabolic process The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids. got7fsn_ti icosanoid metabolism|eicosanoid metabolism|eicosanoid metabolic process biological_process owl:Class
GO:0043757 biolink:NamedThing adenosylcobinamide-phosphate synthase activity Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide. got7fsn_ti CbiB|adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase (ADP-forming)|AdoCbi-P synthase activity EC:6.3.1.10|MetaCyc:RXN-6261|RHEA:21896 molecular_function owl:Class
GO:0034977 biolink:NamedThing ABIN2-NFKB1-MAP3K8 complex A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages. got7fsn_ti ABIN2-NFKB1-TPL-1 complex cellular_component owl:Class
GO:0072699 biolink:NamedThing protein localization to cortical microtubule cytoskeleton A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton. got7fsn_ti protein localisation to cortical microtubule cytoskeleton mah 2012-04-11T01:23:36Z biological_process owl:Class
GO:0034860 biolink:NamedThing 2-mercaptobenzothiazole desulfurase activity Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor. got7fsn_ti UM-BBD_reactionID:r1288|EC:4.4.1.- molecular_function owl:Class
GO:0043423 biolink:NamedThing 3-phosphoinositide-dependent protein kinase binding Binding to a 3-phosphoinositide-dependent protein kinase. got7fsn_ti phosphatidylinositol-3-phosphate-dependent protein kinase binding molecular_function owl:Class
GO:0043057 biolink:NamedThing backward locomotion Posterior movement of an organism, e.g. following the direction of the tail of an animal. got7fsn_ti biological_process owl:Class
GO:0031734 biolink:NamedThing CCR9 chemokine receptor binding Binding to a CCR9 chemokine receptor. got7fsn_ti CCR9 chemokine receptor ligand molecular_function owl:Class
GO:0032619 biolink:NamedThing interleukin-16 production The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-16 production|pro-interleukin-16 production|interleukin-16 biosynthetic process|LCF production|interleukin-16 secretion GO:0042234|GO:0072614 biological_process owl:Class
GO:0045793 biolink:NamedThing positive regulation of cell size Any process that increases cell size. got7fsn_ti upregulation of cell size|up regulation of cell size|activation of cell size|stimulation of cell size|up-regulation of cell size biological_process owl:Class
GO:0022877 biolink:NamedThing protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti fructose PTS transporter activity molecular_function owl:Class
GO:0004552 biolink:NamedThing octanol dehydrogenase activity Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH. got7fsn_ti 1-octanol dehydrogenase activity|octanol:NAD+ oxidoreductase activity MetaCyc:OCTANOL-DEHYDROGENASE-RXN|KEGG_REACTION:R02878|EC:1.1.1.73|RHEA:24620 molecular_function owl:Class
GO:0008747 biolink:NamedThing N-acetylneuraminate lyase activity Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate. got7fsn_ti N-acetylneuraminate pyruvate-lyase activity|NPL|N-acetylneuraminic aldolase activity|N-acetylneuraminic acid lyase activity|N-acetylneuraminic lyase activity|sialic acid aldolase activity|sialic aldolase activity|N-acetylneuraminate aldolase activity|neuraminic aldolase activity|sialate lyase activity|NANA lyase activity|NALase activity|acetylneuraminate pyruvate-lyase activity|neuraminate aldolase activity|neuraminic acid aldolase activity|acetylneuraminate lyase activity|N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)|N-acetylneuraminic acid aldolase activity MetaCyc:ACNEULY-RXN|Reactome:R-HSA-4085217|KEGG_REACTION:R01811|EC:4.1.3.3|RHEA:23296 molecular_function owl:Class
GO:0035543 biolink:NamedThing positive regulation of SNARE complex assembly Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. got7fsn_ti bf 2010-05-10T01:50:02Z biological_process owl:Class
GO:0046196 biolink:NamedThing 4-nitrophenol catabolic process The chemical reactions and pathways resulting in the breakdown of 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion. got7fsn_ti 4-nitrophenol degradation|4-nitrophenol catabolism|4-nitrophenol breakdown biological_process owl:Class
GO:0016492 biolink:NamedThing G protein-coupled neurotensin receptor activity Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. got7fsn_ti G-protein coupled neurotensin receptor activity|G protein coupled neurotensin receptor activity|neurotensin receptor activity, G protein coupled|neurotensin receptor activity, G-protein coupled molecular_function owl:Class
GO:0047445 biolink:NamedThing 3-hydroxy-3-isohexenylglutaryl-CoA lyase activity Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA + 4 H(+) = 7-methyl-3-oxooct-6-enoyl-CoA + acetate. got7fsn_ti beta-hydroxy-beta-isohexenylglutaryl CoA-lyase activity|3-hydroxy-3-isohexenylglutaryl coenzyme A lyase activity|hydroxyisohexenylglutaryl-CoA:acetatelyase activity|3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)|3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase activity|3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase activity UM-BBD_reactionID:r1168|RHEA:23084|MetaCyc:4.1.3.26-RXN|KEGG_REACTION:R08090|EC:4.1.3.26 molecular_function owl:Class
GO:0004941 biolink:NamedThing beta2-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors. got7fsn_ti beta2 adrenoceptor molecular_function owl:Class
GO:0050090 biolink:NamedThing mannuronate reductase activity Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+. got7fsn_ti D-mannonate:nicotinamide adenine dinucleotide (phosphate oxidoreductase (D-mannuronate-forming))|D-mannonate:NAD(P)+ 6-oxidoreductase activity|mannonate dehydrogenase (NAD(P)+)|mannonate dehydrogenase activity|mannonate (nicotinamide adenine dinucleotide (phosphate))dehydrogenase activity EC:1.1.1.131|MetaCyc:MANNURONATE-REDUCTASE-RXN molecular_function owl:Class
GO:0102747 biolink:NamedThing chlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity Catalysis of the reaction: H+ + chlorophyllide a(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) <=> geranylgeranyl-chlorophyll a + diphosphoric acid. got7fsn_ti MetaCyc:RXN-7663 molecular_function owl:Class
GO:0008840 biolink:NamedThing 4-hydroxy-tetrahydrodipicolinate synthase activity Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O. got7fsn_ti DHDPS activity|dihydropicolinate synthetase activity|L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]|dihydrodipicolinate synthetase activity|dihydrodipicolinic acid synthase activity|dihydrodipicolinate synthase activity|L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing) KEGG_REACTION:R02292|MetaCyc:DIHYDRODIPICSYN-RXN|EC:4.3.3.7|RHEA:14845 molecular_function owl:Class
GO:0002083 biolink:NamedThing 4-hydroxybenzoate decaprenyltransferase activity Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate. got7fsn_ti RHEA:44564|Reactome:R-HSA-2162192|EC:2.5.1.39|MetaCyc:RXN-9230 molecular_function owl:Class
GO:0031781 biolink:NamedThing type 3 melanocortin receptor binding Binding to a type 3 melanocortin receptor. got7fsn_ti type 3 melanocortin receptor ligand molecular_function owl:Class
GO:0000111 biolink:NamedThing nucleotide-excision repair factor 2 complex One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p. got7fsn_ti NEF2 complex Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. cellular_component owl:Class
GO:0031828 biolink:NamedThing type 2C serotonin receptor binding Binding to a type 2C serotonin receptor. got7fsn_ti type 2C serotonin receptor ligand|5-hydroxytryptamine 2C receptor binding molecular_function owl:Class
GO:0072019 biolink:NamedThing proximal convoluted tubule development The process whose specific outcome is the progression of the proximal convoluted tubule over time, from its formation to the mature structure. The proximal convoluted tubule is the most proximal portion of the proximal tubule and extends from the glomerular capsule to the proximal straight tubule. got7fsn_ti mah 2010-01-25T02:35:35Z biological_process owl:Class
GO:0099580 biolink:NamedThing ion antiporter activity involved in regulation of postsynaptic membrane potential Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. got7fsn_ti ion antiporter activity involved in regulation of post-synaptic membrane potential molecular_function owl:Class
GO:0004745 biolink:NamedThing NAD-retinol dehydrogenase activity Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. got7fsn_ti retinol dehydrogenase activity|retinol (vitamin A1) dehydrogenase activity|retinene reductase activity|retinal reductase activity|all-trans retinol dehydrogenase activity https://github.com/geneontology/go-ontology/issues/20980 Reactome:R-HSA-2454081|Reactome:R-HSA-2466832|EC:1.1.1.105|MetaCyc:RETINOL-DEHYDROGENASE-RXN|Reactome:R-HSA-5362518|Reactome:R-HSA-5362564|RHEA:21284|Reactome:R-HSA-5362721 molecular_function owl:Class
GO:0008662 biolink:NamedThing 1-phosphofructokinase activity Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate. got7fsn_ti fructose-1-phosphate kinase activity|phosphofructokinase 1|fructose 1-phosphate kinase activity|ATP:D-fructose-phosphate 6-phosphotransferase activity|D-fructose-1-phosphate kinase activity|1-phosphofructokinase (phosphorylating) MetaCyc:1PFRUCTPHOSN-RXN|EC:2.7.1.56|RHEA:14213 molecular_function owl:Class
GO:0102254 biolink:NamedThing neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity Catalysis of the reaction: neoagarotetraose + H2O <=> 3,6-anhydro-alpha-L-galactopyranose + agarotriose. got7fsn_ti EC:3.2.1.159|MetaCyc:RXN-12427 molecular_function owl:Class
GO:0008087 biolink:NamedThing light-activated voltage-gated calcium channel complex A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus. got7fsn_ti light-activated voltage-dependent calcium channel complex|light-activated voltage-sensitive calcium channel complex|light-activated voltage gated calcium channel complex cellular_component owl:Class
GO:0036004 biolink:NamedThing GAF domain binding Binding to a GAF protein domain. got7fsn_ti bf 2011-09-20T04:20:42Z molecular_function owl:Class
GO:0004799 biolink:NamedThing thymidylate synthase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. got7fsn_ti thymidylate synthetase activity|TMP synthetase activity|5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity|dTMP synthase activity|methylenetetrahydrofolate:dUMP C-methyltransferase activity RHEA:12104|EC:2.1.1.45|KEGG_REACTION:R02101|Reactome:R-HSA-73605|MetaCyc:THYMIDYLATESYN-RXN molecular_function owl:Class
GO:0000247 biolink:NamedThing C-8 sterol isomerase activity Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. got7fsn_ti delta-8-delta-7 sterol isomerase activity molecular_function owl:Class
GO:0031711 biolink:NamedThing bradykinin receptor binding Binding to a bradykinin receptor. got7fsn_ti bradykinin receptor ligand molecular_function owl:Class
GO:0044813 biolink:NamedThing glycolytic fermentation via PFOR pathway The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species. got7fsn_ti jl 2013-09-18T16:04:00Z biological_process owl:Class
GO:0000939 biolink:NamedThing inner kinetochore The region of a kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome. got7fsn_ti inner kinetochore of condensed nuclear chromosome|inner centromere core complex|inner kinetochore plate|inner kinetochore of condensed chromosome|condensed nuclear chromosome inner kinetochore|condensed chromosome inner kinetochore https://github.com/geneontology/go-ontology/issues/21126 GO:0000941 cellular_component owl:Class
GO:0016914 biolink:NamedThing follicle-stimulating hormone complex A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity. got7fsn_ti follicle stimulating hormone complex|FSH complex cellular_component owl:Class
GO:1900568 biolink:NamedThing chanoclavine-I aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of chanoclavine-I aldehyde. got7fsn_ti chanoclavine-I aldehyde breakdown|chanoclavine-I aldehyde catabolism|chanoclavine-I aldehyde degradation di 2012-05-15T06:31:21Z biological_process owl:Class
GO:0047524 biolink:NamedThing 16-hydroxysteroid epimerase activity Catalysis of the reaction: 16-alpha-hydroxysteroid = 16-beta-hydroxysteroid. got7fsn_ti 16-hydroxysteroid 16-epimerase activity RHEA:15829|MetaCyc:16-HYDROXYSTEROID-EPIMERASE-RXN|EC:5.1.99.2 molecular_function owl:Class
GO:0045160 biolink:NamedThing myosin I complex A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement. got7fsn_ti cellular_component owl:Class
GO:0045145 biolink:NamedThing single-stranded DNA 5'-3' exodeoxyribonuclease activity Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. got7fsn_ti single-stranded DNA specific 5'-3' exodeoxyribonuclease activity|ssDNA-specific 5'-3' exodeoxyribonuclease activity molecular_function owl:Class
GO:0046861 biolink:NamedThing glyoxysomal membrane The lipid bilayer surrounding a glyoxysome. got7fsn_ti glyoxysome membrane cellular_component owl:Class
GO:0097620 biolink:NamedThing (R)-mandelate dehydrogenase activity Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor. got7fsn_ti D-mandelate dehydrogenase activity In the yeast Rhodotorula graminis, (R)-mandelate dehydrogenase is the first enzyme of the mandelate pathway, and catalyzes the NAD-dependent oxidation of (R)-mandelate to phenylglyoxylate. pr 2014-07-30T09:53:23Z RHEA:43112 molecular_function owl:Class
GO:0002436 biolink:NamedThing immune complex clearance by monocytes and macrophages The process of immune complex clearance by monocytes or macrophages. got7fsn_ti biological_process owl:Class
GO:1900612 biolink:NamedThing F-9775B metabolic process The chemical reactions and pathways involving F-9775B. got7fsn_ti F-9775B metabolism di 2012-05-15T07:03:01Z biological_process owl:Class
GO:0061142 biolink:NamedThing mesothelial-mesenchymal cell signaling involved in early lung development Any process that mediates the transfer of information from a mesothelial cell to an epithelial cell and contributes to the development of the lung. got7fsn_ti mesothelial-mesenchymal cell signalling involved in early lung development dph 2010-05-25T09:35:32Z biological_process owl:Class
GO:0060495 biolink:NamedThing cell-cell signaling involved in lung development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure. got7fsn_ti cell-cell signalling involved in lung development biological_process owl:Class
GO:0001720 biolink:NamedThing conversion of lysyl-tRNA to pyrrolysyl-tRNA The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate). got7fsn_ti biological_process owl:Class
GO:0016630 biolink:NamedThing protochlorophyllide reductase activity Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+. got7fsn_ti NADPH2-protochlorophyllide oxidoreductase activity|protochlorophyllide photooxidoreductase activity|NADPH-protochlorophyllide oxidoreductase activity|protochlorophyllide oxidoreductase activity|chlorophyllide-a:NADP+ 7,8-oxidoreductase activity|NADPH-protochlorophyllide reductase activity MetaCyc:RXN1F-10|EC:1.3.1.33|RHEA:11132 molecular_function owl:Class
GO:0018474 biolink:NamedThing 2-carboxybenzaldehyde dehydrogenase activity Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate. got7fsn_ti UM-BBD_reactionID:r0490|EC:1.2.1.- molecular_function owl:Class
GO:0018082 biolink:NamedThing peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine. got7fsn_ti peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine|peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine|peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine RESID:AA0182 biological_process owl:Class
GO:0004355 biolink:NamedThing glutamate synthase (NADPH) activity Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+. got7fsn_ti NADPH-glutamate synthase activity|NADPH GOGAT|L-glutamate:NADP+ oxidoreductase (transaminating)|L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity|glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity|L-glutamate synthetase activity|glutamine-ketoglutaric aminotransferase activity|L-glutamate synthase activity|GOGAT activity|NADPH-dependent glutamate synthase activity|glutamate synthetase (NADP) activity|glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity|NADPH-linked glutamate synthase Note that this term has a MetaCyc pathway reference as the pathway only has a single step. MetaCyc:GLUTAMATESYN-RXN|EC:1.4.1.13|RHEA:15501|MetaCyc:GLUGLNSYN-PWY|MetaCyc:GLUTSYN-PWY|KEGG_REACTION:R00114 molecular_function owl:Class
GO:0014846 biolink:NamedThing esophagus smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract. got7fsn_ti oesophagus smooth muscle contraction biological_process owl:Class
GO:0070303 biolink:NamedThing negative regulation of stress-activated protein kinase signaling cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. got7fsn_ti negative regulation of stress-activated protein kinase signalling pathway|negative regulation of stress-activated protein kinase signaling pathway|negative regulation of SAPK signaling pathway|down regulation of stress-activated protein kinase signaling pathway|downregulation of stress-activated protein kinase signaling pathway|down-regulation of stress-activated protein kinase signaling pathway|inhibition of stress-activated protein kinase signaling pathway biological_process owl:Class
GO:0004113 biolink:NamedThing 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. got7fsn_ti CNPase activity|2',3'-cyclic nucleoside monophosphate phosphodiesterase|2':3'-cyclic nucleotide 3'-phosphodiesterase activity|cyclic-CMP phosphodiesterase activity|cyclic 2',3'-nucleotide 3'-phosphodiesterase activity|2':3'-CNMP-3'-ase activity|nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity|2',3'-cyclic nucleotide 3'-phosphohydrolase activity|cyclic 2',3'-nucleotide phosphodiesterase|2',3'-cyclic nucleotide 3'-phosphodiesterase activity|2',3'-cyclic AMP phosphodiesterase activity|2',3'-cyclic nucleotide phosphohydrolase EC:3.1.4.37|RHEA:14489|MetaCyc:3.1.4.37-RXN molecular_function owl:Class
GO:0044785 biolink:NamedThing metaphase/anaphase transition of meiotic cell cycle The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis. got7fsn_ti meiotic metaphase/anaphase transition jl 2013-05-02T13:11:28Z biological_process owl:Class
GO:0021976 biolink:NamedThing medulla reticulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord. got7fsn_ti biological_process owl:Class
GO:0032618 biolink:NamedThing interleukin-15 production The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-15 biosynthetic process|interleukin-15 secretion|IL-15 production GO:0072613|GO:0042233 biological_process owl:Class
GO:0043129 biolink:NamedThing surfactant homeostasis Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli. got7fsn_ti biological_process owl:Class
GO:0071324 biolink:NamedThing cellular response to disaccharide stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus. got7fsn_ti mah 2009-12-10T05:26:14Z biological_process owl:Class
GO:0044729 biolink:NamedThing hemi-methylated DNA-binding Binding to double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. got7fsn_ti double-stranded hemi-methylated DNA binding jl 2012-10-24T14:58:14Z molecular_function owl:Class
GO:0003346 biolink:NamedThing epicardium-derived cell migration to the myocardium The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium. got7fsn_ti dph 2009-12-01T11:00:42Z biological_process owl:Class
GO:0030730 biolink:NamedThing sequestering of triglyceride The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system. got7fsn_ti storage of triglyceride|retention of triglyceride|triglyceride sequestration|triglyceride retention|sequestration of triglyceride|retention of triacylglycerol|triglyceride sequestering|triacylglycerol storage|triacylglycerol retention|storage of triacylglycerol|triacylglycerol sequestration|triglyceride storage|triacylglycerol sequestering|sequestration of triacylglycerol|sequestering of triacylglycerol biological_process owl:Class
GO:0043846 biolink:NamedThing DNA polymerase III, clamp loader complex A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. got7fsn_ti DNA polymerase III, DnaX subcomplex|clamp loader complex|DNA polymerase III, DnaX complex cellular_component owl:Class
GO:1990023 biolink:NamedThing mitotic spindle midzone The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner. got7fsn_ti vw 2013-02-05T15:41:48Z cellular_component owl:Class
GO:0018753 biolink:NamedThing cyanuric acid amidohydrolase activity Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2. got7fsn_ti EC:3.5.2.15|RHEA:14641|MetaCyc:R468-RXN|UM-BBD_reactionID:r0116 molecular_function owl:Class
GO:0070979 biolink:NamedThing protein K11-linked ubiquitination A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains. got7fsn_ti mah 2009-10-26T04:50:57Z biological_process owl:Class
GO:0052924 biolink:NamedThing all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate. got7fsn_ti solanesyl diphosphate synthetase activity|nonaprenyl diphosphate synthase activity|solanesyl diphosphate synthase activity EC:2.5.1.85|RHEA:27594|MetaCyc:RXN-11486|KEGG_REACTION:R09251 molecular_function owl:Class
GO:0070888 biolink:NamedThing E-box binding Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. got7fsn_ti E-box promoter binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. mah 2009-08-28T10:37:01Z molecular_function owl:Class
GO:0046684 biolink:NamedThing response to pyrethroid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pyrethroid stimulus. Pyrethroids are a group of growth regulators, analogous to insect juvenile hormones, that interfere with the development of insect larvae and are used in the control of insects that are harmful in the adult stage. got7fsn_ti pyrethroid susceptibility/resistance|pyrethroid resistance biological_process owl:Class
GO:0102347 biolink:NamedThing trans-arachidon-2-enoyl-CoA reductase activity Catalysis of the reaction: icosanoyl-CoA(4-) + NADP(3-) <=> trans-2-icosenoyl-CoA(4-) + NADPH(4-) + H+. got7fsn_ti MetaCyc:RXN-13306 molecular_function owl:Class
GO:0047093 biolink:NamedThing 4-hydroxyquinoline 3-monooxygenase activity Catalysis of the reaction: H(+) + NADH + O(2) + quinolin-4-ol = H(2)O + NAD(+) + quinoline-3,4-diol. got7fsn_ti quinolin-4(1H)-one,NADH:oxygen oxidoreductase (3-oxygenating)|1-H-4-oxoquinoline 3-monooxygenase activity|quinolin-4(1H)-one 3-monooxygenase activity EC:1.14.13.62|RHEA:19325|MetaCyc:1.14.13.62-RXN|KEGG_REACTION:R05154 molecular_function owl:Class
GO:0098577 biolink:NamedThing inactive sex chromosome A sex chromosome that has been inactivated. got7fsn_ti inactivated sex chromosome cellular_component owl:Class
GO:0140547 biolink:NamedThing acquisition of seed longevity The acquisition of seed longevity is the ordered series of events during seed development, that prevent embryo deterioration and ROS damage and thus contribute to seed viability over time or in response to adverse environmental conditions. These events include protective (e.g. production of glassy cytoplasm ) and repair (e.g. oxidative stress responses) processes. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19829 pg 2020-11-11T21:28:55Z biological_process owl:Class
GO:0052910 biolink:NamedThing 23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA. got7fsn_ti rRNA methyltransferase ermC' activity|ermC 23S rRNA methyltransferase activity|rRNA:m(6)A methyltransferase ermC' activity EC:2.1.1.184|MetaCyc:RXN-11597|RHEA:42784 molecular_function owl:Class
GO:0047492 biolink:NamedThing xanthan lyase activity Catalysis of the reaction: xanthan = oligosaccharide with 4-deoxy-alpha-L-threo-hex-4-enuronosyl end + pyruvylate mannose. This reaction is the eliminative cleavage of the terminal beta-D-mannosyl-beta-D-1,4-glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain. got7fsn_ti EC:4.2.2.12|MetaCyc:4.2.2.12-RXN molecular_function owl:Class
GO:0140499 biolink:NamedThing negative regulation of mitotic spindle assembly checkpoint signaling Any process that stops, prevents, or reduces the frequency, rate or extent of negative regulation of mitotic spindle assembly checkpoint signaling. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19818 pg 2020-07-22T15:44:06Z biological_process owl:Class
GO:0002454 biolink:NamedThing peripheral B cell deletion The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection. got7fsn_ti peripheral B lymphocyte deletion|peripheral B-cell deletion|peripheral B-lymphocyte deletion biological_process owl:Class
GO:0090437 biolink:NamedThing socket cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support. got7fsn_ti tb 2012-07-31T17:01:28Z biological_process owl:Class
GO:0050628 biolink:NamedThing 2-oxopropyl-CoM reductase (carboxylating) activity Catalysis of the reaction: acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO(2) + NADPH. got7fsn_ti 2-mercaptoethanesulfonate,acetoacetate:NADP+ oxidoreductase (decarboxylating)|2-KPCC activity|NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase activity|NADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity KEGG_REACTION:R05713|UM-BBD_reactionID:r0854|RHEA:16977|MetaCyc:1.8.1.5-RXN|EC:1.8.1.5 molecular_function owl:Class
GO:0102540 biolink:NamedThing D-mannose 6-phosphate 1-epimerase activity Catalysis of the reaction: alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate. got7fsn_ti MetaCyc:RXN-14815 molecular_function owl:Class
GO:0033893 biolink:NamedThing ribonuclease IV activity Catalysis of the endonucleolytic cleavage of poly(A) to fragments terminated by 3'-hydroxy and 5'-phosphate groups. got7fsn_ti endoribonuclease IV activity EC:3.1.26.6|MetaCyc:3.1.26.6-RXN molecular_function owl:Class
GO:0035255 biolink:NamedThing ionotropic glutamate receptor binding Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. got7fsn_ti molecular_function owl:Class
GO:0004089 biolink:NamedThing carbonate dehydratase activity Catalysis of the reaction: H2CO3 = CO2 + H2O. got7fsn_ti carboxyanhydrase activity|carbonic dehydratase activity|carbonate anhydrase activity|carbonic anhydrase activity|anhydrase activity|carbonate hydro-lyase (carbon-dioxide-forming)|carbonate hydro-lyase activity|carbonic anhydrase A|carbonic acid anhydrase activity Reactome:R-HSA-1475436|Reactome:R-HSA-1475026|Reactome:R-HSA-1475028|EC:4.2.1.1|Reactome:R-HSA-1475435|Reactome:R-HSA-1475017|RHEA:10748|MetaCyc:CARBODEHYDRAT-RXN|Reactome:R-HSA-1237059|Reactome:R-HSA-1237045|Reactome:R-HSA-1237081|Reactome:R-HSA-1475022|Reactome:R-HSA-1237047|Reactome:R-HSA-1475032|Reactome:R-HSA-1475025 molecular_function owl:Class
GO:0007139 biolink:NamedThing meiotic telophase II The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0102743 biolink:NamedThing eriodictyol,NADPH:oxygen oxidoreductase activity Catalysis of the reaction: H+ + eriodictyol + NADPH + O2 <=> 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate(1-) + NADP + 2 H2O. got7fsn_ti MetaCyc:RXN-7653 molecular_function owl:Class
GO:0005135 biolink:NamedThing interleukin-3 receptor binding Binding to an interleukin-3 receptor. got7fsn_ti IL-3|interleukin-3 receptor ligand molecular_function owl:Class
GO:0007512 biolink:NamedThing adult heart development The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure. got7fsn_ti adult cardiac development biological_process owl:Class
GO:0047457 biolink:NamedThing exo-(1,4)-alpha-D-glucan lyase activity Catalysis of the reaction: linear alpha-D-glucan = 1,5-anhydro-D-fructose + beta-D-glucose. got7fsn_ti alpha-1,4-glucan lyase activity|alpha-(1->4)-glucan 1,5-anhydro-D-fructose eliminase activity|exo-(1->4)-alpha-D-glucan lyase activity|(1->4)-alpha-D-glucan exo-4-lyase (1,5-anhydro-D-fructose-forming)|alpha-1,4-glucan 1,5-anhydro-D-fructose eliminase activity|exo-alpha-1,4-glucan lyase activity|alpha-1,4-glucan exo-lyase activity EC:4.2.2.13|MetaCyc:4.2.2.13-RXN molecular_function owl:Class
GO:0102696 biolink:NamedThing cis-zeatin UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cis-zeatin = H+ + 9-(alpha-D-glucosyl)-cis-zeatin + UDP. got7fsn_ti MetaCyc:RXN-4734 molecular_function owl:Class
GO:0008973 biolink:NamedThing phosphopentomutase activity Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate. got7fsn_ti deoxyribose phosphomutase activity|alpha-D-ribose 1,5-phosphomutase activity|phosphodeoxyribomutase activity|alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity|phosphoribomutase activity|deoxyribomutase activity|D-ribose 1,5-phosphomutase activity Reactome:R-HSA-8982667|Reactome:R-HSA-6787329|RHEA:18793|MetaCyc:PPENTOMUT-RXN|EC:5.4.2.7 molecular_function owl:Class
GO:0039616 biolink:NamedThing T=2 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers. got7fsn_ti The T=2 symmetry is an non-official appellation; strictly speaking the capsid has a T=1 symmetry with each unit composed of a homodimer. bf 2012-07-18T02:01:55Z VZ:838 cellular_component owl:Class
GO:0023031 biolink:NamedThing MHC class Ib protein binding, via lateral surface Binding to a major histocompatibility complex class Ib molecules via the lateral surface. got7fsn_ti 2010-02-16T09:30:50Z molecular_function owl:Class
GO:0008413 biolink:NamedThing 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. got7fsn_ti 8-oxo-7,8-dihydroguanosine triphosphatase activity|7,8-dihydro-8-oxoguanine-triphosphatase activity|8-oxo-7,8-dihydroguanine triphosphatase activity|8-oxo-GTPase activity RHEA:60032|EC:3.6.1.69 molecular_function owl:Class
GO:0071124 biolink:NamedThing alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex A protein complex that consists of an alpha1-beta1 integrin complex bound to tyrosine-protein phosphatase non-receptor type 2. got7fsn_ti ITGA1-ITGB1-PTPN2 complex mah 2009-11-13T02:22:51Z cellular_component owl:Class
GO:0000969 biolink:NamedThing tRNA exon ligation utilizing ATP as source of linkage phosphate A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species. got7fsn_ti krc 2009-04-28T10:29:37Z biological_process owl:Class
GO:0097108 biolink:NamedThing hedgehog family protein binding Binding to a member of the hedgehog protein family, signaling proteins involved in development. got7fsn_ti pr 2011-07-28T10:06:45Z molecular_function owl:Class
GO:0030380 biolink:NamedThing interleukin-17E receptor binding Binding to an interleukin-17E receptor. got7fsn_ti interleukin-17E receptor ligand|IL-17E molecular_function owl:Class
GO:0031908 biolink:NamedThing glyoxysomal lumen The volume enclosed by the membranes of a glyoxysome. got7fsn_ti cellular_component owl:Class
GO:0047674 biolink:NamedThing apiose 1-reductase activity Catalysis of the reaction: D-apiitol + NAD(+) = D-apiose + H(+) + NADH. got7fsn_ti D-apiose reductase activity|D-apiitol:NAD+ 1-oxidoreductase activity|D-apiitol reductase activity EC:1.1.1.114|KEGG_REACTION:R03577|MetaCyc:APIOSE-1-REDUCTASE-RXN|RHEA:15301 molecular_function owl:Class
GO:0033638 biolink:NamedThing modulation by symbiont of host response to heat Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response to heat shock biological_process owl:Class
GO:0018633 biolink:NamedThing dimethyl sulfide monooxygenase activity Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde. got7fsn_ti dimethyl sulphide monooxygenase activity UM-BBD_reactionID:r0208|EC:1.14.13.- molecular_function owl:Class
GO:0102557 biolink:NamedThing protopanaxadiol 6-hydroxylase activity Catalysis of the reaction: (20S)-protopanaxadiol + O2 + NADPH(4-) + H+ <=> protopanaxatriol + NADP + H2O. got7fsn_ti MetaCyc:RXN-14978|EC:1.14.14.121|RHEA:22272 molecular_function owl:Class
GO:0036048 biolink:NamedThing protein desuccinylation The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein. got7fsn_ti bf 2011-12-12T09:42:35Z biological_process owl:Class
GO:0106225 biolink:NamedThing peptidyl-lysine 2-hydroxyisobutyrylation The 2-hydroxyisobutyrylation of a lysine residue in a protein. got7fsn_ti hjd 2019-10-17T18:51:15Z biological_process owl:Class
GO:0002321 biolink:NamedThing natural killer cell progenitor differentiation The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor. got7fsn_ti biological_process owl:Class
GO:0036403 biolink:NamedThing arachidonate 8(S)-lipoxygenase activity Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. got7fsn_ti 8(S)-lipoxygenase activity|8-lipoxygenase (S-type) This activity produces the S-enantiomer of HPETE, 8(S)-HPETE. For the reaction producing the S-enantiomer, see GO:0047677. bf 2013-08-14T11:48:46Z RHEA:38675|KEGG_REACTION:R07053 molecular_function owl:Class
GO:0060062 biolink:NamedThing Spemann organizer formation at the dorsal lip of the blastopore Formation of the specialized region at the dorsal lip of the blatopore of the embryo that acts as the main signaling center establishing the vertebrate body plan. got7fsn_ti Spemann's organizer formation at the dorsal lip of the blastopore|Spemann-Mangold organizer formation at the dorsal lip of the blastopore Occurs in amphibia, cephalochordates, cyclostomes and cartilaginous fish. biological_process owl:Class
GO:0047061 biolink:NamedThing glucose-fructose oxidoreductase activity Catalysis of the reaction: D-fructose + D-glucose = D-glucitol + D-glucono-1,5-lactone. got7fsn_ti D-glucose:D-fructose oxidoreductase activity EC:1.1.99.28|KEGG_REACTION:R00874|RHEA:20637|MetaCyc:1.1.99.28-RXN molecular_function owl:Class
GO:0047021 biolink:NamedThing 15-hydroxyprostaglandin dehydrogenase (NADP+) activity Catalysis of the reaction: NADP(+) + prostaglandin E(1) = 15-dehydro-prostaglandin E1 + H(+) + NADPH. got7fsn_ti (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase activity|NADP-linked 15-hydroxyprostaglandin dehydrogenase|type II 15-hydroxyprostaglandin dehydrogenase activity|NADP-dependent 15-hydroxyprostaglandin dehydrogenase|NADP-specific 15-hydroxyprostaglandin dehydrogenase EC:1.1.1.197|MetaCyc:1.1.1.197-RXN|RHEA:11636|KEGG_REACTION:R04552 molecular_function owl:Class
GO:0102088 biolink:NamedThing N-(4-hydroxybenzoyl)-L-glutamate synthetase activity Catalysis of the reaction: 4-hydroxybenzoic acid + L-glutamate + ATP <=> H+ + N-(4-hydroxybenzoyl)-L-glutamate + AMP + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10887 molecular_function owl:Class
GO:0048466 biolink:NamedThing androecium development The process whose specific outcome is the progression of the androecium over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0009754 biolink:NamedThing detection of jasmonic acid stimulus The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule. got7fsn_ti perception of jasmonic acid stimulus biological_process owl:Class
GO:0046203 biolink:NamedThing spermidine catabolic process The chemical reactions and pathways resulting in the breakdown of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. got7fsn_ti spermidine degradation|spermidine catabolism|spermidine breakdown biological_process owl:Class
GO:0010111 biolink:NamedThing glyoxysome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway. got7fsn_ti glyoxysome organization and biogenesis|glyoxysome organisation biological_process owl:Class
GO:0031885 biolink:NamedThing type 1 member 2 taste receptor binding Binding to a type 1 member 2 taste receptor. got7fsn_ti type 1 member 2 taste receptor ligand molecular_function owl:Class
GO:0051063 biolink:NamedThing CDP reductase activity Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin. got7fsn_ti CDP reduction MetaCyc:CDPREDUCT-RXN molecular_function owl:Class
GO:0021718 biolink:NamedThing superior olivary nucleus development The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. got7fsn_ti superior olive development biological_process owl:Class
GO:0031825 biolink:NamedThing type 1F serotonin receptor binding Binding to a type 1F serotonin receptor. got7fsn_ti 5-hydroxytryptamine 1F receptor binding|type 1F serotonin receptor ligand molecular_function owl:Class
GO:0102848 biolink:NamedThing 1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-18:2-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8310|EC:1.14.19.35 molecular_function owl:Class
GO:0019546 biolink:NamedThing arginine deiminase pathway The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase. got7fsn_ti MetaCyc:ARGDEGRAD-PWY biological_process owl:Class
GO:0071925 biolink:NamedThing thymic stromal lymphopoietin production The appearance of thymic stromal lymphopoietin (TSLP) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti TSLP production mah 2010-09-28T11:38:55Z biological_process owl:Class
GO:0043866 biolink:NamedThing adenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin. got7fsn_ti AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)|thioredoxin-dependent 5'-adenylylsulfate reductase activity|AMP, sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming) EC:1.8.4.10|RHEA:21976 molecular_function owl:Class
GO:0102684 biolink:NamedThing L-phenylalanine N-monooxygenase activity Catalysis of the reaction: L-phenylalanine + 2 NADPH + 2 O2 + 2 H+ <=> (E)-phenylacetaldehyde oxime + 2 NADP + 3 H2O + carbon dioxide. got7fsn_ti EC:1.14.14.40|MetaCyc:RXN-4602|RHEA:33263 molecular_function owl:Class
GO:0140105 biolink:NamedThing interleukin-10-mediated signaling pathway A series of molecular signals initiated by the binding of interleukin-10 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti IL-10-mediated signaling pathway|interleukin-10-mediated signalling pathway pg 2017-09-22T16:04:42Z biological_process owl:Class
GO:1990393 biolink:NamedThing 3M complex A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity. got7fsn_ti sp 2014-06-05T06:40:49Z cellular_component owl:Class
GO:0047934 biolink:NamedThing glucose 1-dehydrogenase (NAD+) activity Catalysis of the reaction: D-glucose + NAD+ = D-glucono-1,5-lactone + NADH. got7fsn_ti D-glucose:NAD+ 1-oxidoreductase activity|D-aldohexose dehydrogenase activity|D-glucose:NAD oxidoreductase activity RHEA:14293|MetaCyc:GLUCOSE-1-DEHYDROGENASE-NAD+-RXN|EC:1.1.1.118 molecular_function owl:Class
GO:0140306 biolink:NamedThing lipoprotein releasing activity The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex. got7fsn_ti https://github.com/geneontology/go-ontology/issues/17058 pg 2019-03-22T14:25:43Z molecular_function owl:Class
GO:0102285 biolink:NamedThing 1-deoxy-11-oxopentalenate oxygenase activity Catalysis of the reaction: 1-deoxy-11-oxopentalenate + O2 + NADPH + H+ = pentalenolactone D + H2O + NADP. got7fsn_ti EC:1.14.13.170|RHEA:34635|MetaCyc:RXN-12654 molecular_function owl:Class
GO:0030346 biolink:NamedThing protein phosphatase 2B binding Binding to a protein phosphatase 2B. got7fsn_ti protein phosphatase 3 binding|calcineurin binding molecular_function owl:Class
GO:0098761 biolink:NamedThing cellular response to interleukin-7 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus. got7fsn_ti cellular response to IL-7 biological_process owl:Class
GO:0140225 biolink:NamedThing DNA topoisomerase III-beta-TDRD3 complex A protein complex that has DNA topoisomerase type I and RNA topoisomerase activities. got7fsn_ti Top3-beta-TDRD3 complex pg 2018-05-29T10:05:33Z cellular_component owl:Class
GO:0001223 biolink:NamedThing transcription coactivator binding Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. got7fsn_ti RNA polymerase II transcription coactivator binding https://github.com/geneontology/go-ontology/issues/19354 krc 2012-04-16T03:30:16Z GO:0001225 molecular_function owl:Class
GO:0102546 biolink:NamedThing mannosylglycerate hydrolase activity Catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate. got7fsn_ti MetaCyc:RXN-14900|RHEA:58456 molecular_function owl:Class
GO:1990327 biolink:NamedThing collagen type XXV trimer A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane. got7fsn_ti bhm 2014-03-17T09:28:50Z cellular_component owl:Class
GO:0031680 biolink:NamedThing G-protein beta/gamma-subunit complex The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange. got7fsn_ti heterotrimeric G-protein GTPase, beta-subunit|G-beta/G-gamma complex See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. cellular_component owl:Class
GO:0018656 biolink:NamedThing phenanthrene 3,4-monooxygenase activity Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide. got7fsn_ti EC:1.14.13.-|UM-BBD_reactionID:r0508 molecular_function owl:Class
GO:1990524 biolink:NamedThing INA complex A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p. got7fsn_ti INAC jl 2014-11-03T16:03:39Z cellular_component owl:Class
GO:0061690 biolink:NamedThing lipoamidase activity Catalysis of the cleavage of the amide bond to release lipoic acid from a lipoylated protein. got7fsn_ti lipoyl-X-hydrolase dph 2015-05-05T10:06:49Z MetaCyc:RXN-13031 molecular_function owl:Class
GO:0046998 biolink:NamedThing (S)-usnate reductase activity Catalysis of the reaction: (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6-methylcyclohexa-2,4-dien-1-one + NAD(+) = (S)-usnate + 2 H(+) + NADH. got7fsn_ti L-usnic acid dehydrogenase activity|reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming) EC:1.1.1.199|KEGG_REACTION:R07345|RHEA:21876|MetaCyc:1.1.1.199-RXN molecular_function owl:Class
GO:0044245 biolink:NamedThing polysaccharide digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class
GO:0046095 biolink:NamedThing deoxyinosine biosynthetic process The chemical reactions and pathways resulting in the formation of deoxyinosine, hypoxanthine deoxyriboside. got7fsn_ti deoxyinosine synthesis|deoxyinosine anabolism|deoxyinosine biosynthesis|deoxyinosine formation biological_process owl:Class
GO:0047727 biolink:NamedThing isobutyryl-CoA mutase activity Catalysis of the reaction: isobutyryl-CoA = butanoyl-CoA. got7fsn_ti 2-methylpropanoyl-CoA CoA-carbonylmutase activity|isobutyryl coenzyme A mutase activity|butyryl-CoA:isobutyryl-CoA mutase activity MetaCyc:ISOBUTYRYL-COA-MUTASE-RXN|RHEA:13141|EC:5.4.99.13|KEGG_REACTION:R01181 molecular_function owl:Class
GO:0044286 biolink:NamedThing peg and socket contact A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells. got7fsn_ti ball and socket contact jl 2010-02-02T10:15:27Z NIF_Subcellular:sao1943947957 cellular_component owl:Class
GO:0034817 biolink:NamedThing cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-. got7fsn_ti UM-BBD_reactionID:r1144 molecular_function owl:Class
GO:0006577 biolink:NamedThing amino-acid betaine metabolic process The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid. got7fsn_ti betaine metabolic process|betaine metabolism biological_process owl:Class
GO:0031799 biolink:NamedThing type 2 metabotropic glutamate receptor binding Binding to a type 2 metabotropic glutamate receptor. got7fsn_ti type 2 metabotropic glutamate receptor ligand molecular_function owl:Class
GO:0034516 biolink:NamedThing response to vitamin B6 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. got7fsn_ti biological_process owl:Class
GO:0015473 biolink:NamedThing fimbrial usher porin activity A porin that acts in the assembly of fimbria together with fimbrial chaperone. got7fsn_ti molecular_function owl:Class
GO:0047529 biolink:NamedThing 2,3-dimethylmalate lyase activity Catalysis of the reaction: (2R,3S)-2,3-dimethylmalate = propanoate + pyruvate. got7fsn_ti (2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)|(2R,3S)-2,3-dimethylmalate pyruvate-lyase activity|2,3-dimethylmalate pyruvate-lyase activity KEGG_REACTION:R01355|RHEA:10472|EC:4.1.3.32|MetaCyc:23-DIMETHYLMALATE-LYASE-RXN molecular_function owl:Class
GO:0004090 biolink:NamedThing carbonyl reductase (NADPH) activity Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+. got7fsn_ti NADPH-dependent carbonyl reductase activity|xenobiotic ketone reductase activity|NADPH2-dependent carbonyl reductase activity|aldehyde reductase 1|secondary-alcohol:NADP+ oxidoreductase activity|aldehyde reductase I activity|ALR3|nonspecific NADPH-dependent carbonyl reductase activity|prostaglandin 9-ketoreductase activity|carbonyl reductase activity EC:1.1.1.184|RHEA:19257|Reactome:R-HSA-8937419|MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN molecular_function owl:Class
GO:0010573 biolink:NamedThing vascular endothelial growth factor production The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti VEGF production biological_process owl:Class
GO:0007387 biolink:NamedThing anterior compartment pattern formation The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo. got7fsn_ti anterior compartment pattern specification biological_process owl:Class
GO:0097692 biolink:NamedThing histone H3-K4 monomethylation The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone. got7fsn_ti pr 2015-11-05T11:23:15Z biological_process owl:Class
GO:0031691 biolink:NamedThing alpha-1A adrenergic receptor binding Binding to an alpha-1A adrenergic receptor. got7fsn_ti alpha-1A adrenergic receptor ligand molecular_function owl:Class
GO:0030110 biolink:NamedThing HLA-C specific inhibitory MHC class I receptor activity Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte. got7fsn_ti molecular_function owl:Class
GO:0032616 biolink:NamedThing interleukin-13 production The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-13 biosynthetic process|IL-13 production|interleukin-13 secretion GO:0072611|GO:0042231 biological_process owl:Class
GO:0034291 biolink:NamedThing canonical holin activity A compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell. got7fsn_ti molecular_function owl:Class
GO:0042018 biolink:NamedThing interleukin-22 receptor activity Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti IL-22 receptor activity|IL-22R molecular_function owl:Class
GO:0102384 biolink:NamedThing 19-O-beta-glucopyranosyl-steviol glucosyltransferase activity Catalysis of the reaction: 19-O-beta-glucopyranosyl-steviol + UDP-alpha-D-glucose <=> rubusoside + UDP + H+. got7fsn_ti MetaCyc:RXN-13521 molecular_function owl:Class
GO:0018773 biolink:NamedThing acetylpyruvate hydrolase activity Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate. got7fsn_ti 2,4-dioxopentanoate acetylhydrolase activity RHEA:16097|MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN|EC:3.7.1.6|UM-BBD_reactionID:r0095|KEGG_REACTION:R00324 molecular_function owl:Class
GO:0052748 biolink:NamedThing baicalin beta-D-glucuronidase activity Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate. got7fsn_ti baicalinase activity|5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase activity ai 2011-09-21T12:58:43Z MetaCyc:RXN-11760|EC:3.2.1.167|KEGG_REACTION:R09533|RHEA:28130 molecular_function owl:Class
GO:0045352 biolink:NamedThing interleukin-1 type I receptor antagonist activity Blocks the binding of interleukin-1 to interleukin-1 type I receptors. got7fsn_ti IL-1ra type I molecular_function owl:Class
GO:0039623 biolink:NamedThing T=25 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres. got7fsn_ti bf 2012-07-18T02:21:43Z VZ:810 cellular_component owl:Class
GO:0030625 biolink:NamedThing U11 snRNA binding Binding to a U11 small nuclear RNA (U11 snRNA). got7fsn_ti molecular_function owl:Class
GO:0050488 biolink:NamedThing ecdysteroid UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid. got7fsn_ti ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity GO:0050489 molecular_function owl:Class
GO:0018028 biolink:NamedThing peptidyl-lysine myristoylation The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine. got7fsn_ti peptidyl-lysine myristylation RESID:AA0078 biological_process owl:Class
GO:0034652 biolink:NamedThing extrachromosomal circular DNA localization involved in cell aging A process in which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging. got7fsn_ti extrachromosomal circular DNA localization during cell ageing|extrachromosomal circular DNA localisation involved in cell aging|extrachromosomal circular DNA localization during cell aging Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. biological_process owl:Class
GO:0001301 biolink:NamedThing progressive alteration of chromatin involved in cell aging Any chromatin organization process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. got7fsn_ti progressive alteration of chromatin during cell ageing|progressive alteration of chromatin during cell aging|age-dependent accumulation of genetic damage biological_process owl:Class
GO:0030980 biolink:NamedThing alpha-glucan catabolic process The chemical reactions and pathways resulting in the breakdown of alpha-glucans. got7fsn_ti alpha-glucan degradation|alpha-glucan breakdown|alpha-glucan catabolism biological_process owl:Class
GO:0102629 biolink:NamedThing patuletin 3'-O-methyltransferase activity Catalysis of the reaction: patuletin + S-adenosyl-L-methionine <=> quercetagetin 3',6-dimethyl ether + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-15534 molecular_function owl:Class
GO:0018466 biolink:NamedThing limonene-1,2-diol dehydrogenase activity Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene. got7fsn_ti EC:1.1.99.-|UM-BBD_reactionID:r0735 molecular_function owl:Class
GO:0034886 biolink:NamedThing gamma-aminovinylacetate deaminase activity Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3. got7fsn_ti EC:3.5.99.-|UM-BBD_reactionID:r1351 molecular_function owl:Class
GO:1990567 biolink:NamedThing DPS complex A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22. got7fsn_ti al 2014-11-27T09:56:18Z cellular_component owl:Class
GO:0015946 biolink:NamedThing methanol oxidation The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. got7fsn_ti MetaCyc:CO2FORM-PWY biological_process owl:Class
GO:0015945 biolink:NamedThing methanol metabolic process The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent. got7fsn_ti methanol metabolism biological_process owl:Class
GO:0102700 biolink:NamedThing alpha-thujene synthase activity Catalysis of the reaction: geranyl diphosphate(3-) <=> alpha-thujene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-5105 molecular_function owl:Class
GO:0120203 biolink:NamedThing rod photoreceptor disc lumen The volume enclosed by the membrane of a rod photoreceptor cell disc membrane. got7fsn_ti krc 2019-05-07T23:49:50Z cellular_component owl:Class
GO:0004719 biolink:NamedThing protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. got7fsn_ti L-aspartyl/L-isoaspartyl protein methyltransferase activity|L-isoaspartyl protein carboxyl methyltransferase activity|protein L-isoaspartate methyltransferase activity|protein D-aspartate methyltransferase activity|D-aspartyl/L-isoaspartyl methyltransferase activity|protein-L-isoaspartate O-methyltransferase activity|protein-L-isoaspartate(D-aspartate) O-methyltransferase activity|L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity|protein O-methyltransferase (L-isoaspartate)|S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity|protein (D-aspartate) methyltransferase activity|protein-beta-aspartate O-methyltransferase activity|protein L-isoaspartyl methyltransferase activity|protein beta-aspartate O-methyltransferase activity RHEA:12705|Reactome:R-HSA-5676966|EC:2.1.1.77|MetaCyc:2.1.1.77-RXN molecular_function owl:Class
GO:0097271 biolink:NamedThing protein localization to bud neck A process in which a protein is transported to, or maintained at, a location within a cellular bud neck. got7fsn_ti protein localization to cellular bud neck|protein localisation to bud neck pr 2012-03-20T03:39:20Z biological_process owl:Class
GO:0097266 biolink:NamedThing phenylacetyl-CoA 1,2-epoxidase activity Catalysis of the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+). got7fsn_ti phenylacetyl-CoA monooxygenase activity|phenylacetyl-CoA epoxidase activity|ring 1,2-phenylacetyl-CoA epoxidase activity pr 2012-03-13T09:22:47Z RHEA:32171|EC:1.14.13.149|KEGG_REACTION:R09838 molecular_function owl:Class
GO:0047392 biolink:NamedThing CMP-N-acylneuraminate phosphodiesterase activity Catalysis of the reaction: H2O + CMP-N-acylneuraminate = N-acylneuraminate + CMP. got7fsn_ti CMP-N-acetylneuraminate hydrolase activity|cytidine monophosphosialic hydrolase activity|CMP-N-acylneuraminate N-acylneuraminohydrolase activity|CMP-sialate hydrolase activity|CMP-N-acylneuraminic acid hydrolase activity|cytidine monophosphate-N-acetylneuraminic acid hydrolase activity|CMP-sialic acid hydrolase activity|cytidine monophosphosialate hydrolase activity RHEA:20185|MetaCyc:3.1.4.40-RXN|EC:3.1.4.40 molecular_function owl:Class
GO:0018693 biolink:NamedThing ethylbenzene hydroxylase activity Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2). got7fsn_ti ethylbenzene:(acceptor) oxidoreductase activity|ethylbenzene dehydrogenase activity KEGG_REACTION:R05745|RHEA:17897|MetaCyc:RXN-1301|UM-BBD_reactionID:r0234|EC:1.17.99.2 molecular_function owl:Class
GO:1990795 biolink:NamedThing rod bipolar cell terminal bouton A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer. got7fsn_ti sl 2015-07-09T21:11:53Z cellular_component owl:Class
GO:0031704 biolink:NamedThing apelin receptor binding Binding to an apelin receptor. got7fsn_ti APJ receptor binding|apelin receptor ligand GO:0042569 molecular_function owl:Class
GO:0050766 biolink:NamedThing positive regulation of phagocytosis Any process that activates or increases the frequency, rate or extent of phagocytosis. got7fsn_ti up regulation of phagocytosis|up-regulation of phagocytosis|upregulation of phagocytosis|stimulation of phagocytosis|activation of phagocytosis biological_process owl:Class
GO:0001065 biolink:NamedThing mitochondrial single subunit type RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. got7fsn_ti krc 2010-10-19T03:50:51Z molecular_function owl:Class
GO:0043365 biolink:NamedThing [formate-C-acetyltransferase]-activating enzyme activity Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical. got7fsn_ti formate-C-acetyltransferase-activating enzyme|PFL activase activity|PFL-glycine:S-adenosyl-L-methionine H transferase (flavodoxin-oxidizing, S-adenosyl-L-methionine-cleaving) activity|[pyruvate formate-lyase]-activating enzyme activity|pyruvate formate-lyase-activating enzyme|formate acetyltransferase activating enzyme activity|formate C-acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving)|formate acetyltransferase-glycine dihydroflavodoxin:S-adenosyl-L-methionine oxidoreductase (S-adenosyl-L-methionine cleaving) activity https://github.com/geneontology/go-ontology/issues/14190 GO:0008862 EC:1.97.1.4|RHEA:19225|MetaCyc:TDCEACT-RXN molecular_function owl:Class
GO:0018568 biolink:NamedThing 3,4-dihydroxyphenanthrene dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate. got7fsn_ti UM-BBD_reactionID:r0501|EC:1.13.11.- molecular_function owl:Class
GO:0044817 biolink:NamedThing hydrogen generation via biophotolysis The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae. got7fsn_ti hydrogen biosynthesis via biophotolysis jl 2013-10-22T14:36:54Z biological_process owl:Class
GO:0004490 biolink:NamedThing methylglutaconyl-CoA hydratase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O. got7fsn_ti (S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity|methylglutaconyl coenzyme A hydratase activity|methylglutaconase activity|(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)|3-methylglutaconyl CoA hydratase activity EC:4.2.1.18|KEGG_REACTION:R02085|RHEA:21536|MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN|Reactome:R-HSA-70785 molecular_function owl:Class
GO:0018659 biolink:NamedThing 4-hydroxybenzoate 3-monooxygenase activity Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O. got7fsn_ti 4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)|p-hydroxybenzoic acid hydrolase activity|para-hydroxybenzoate hydroxylase activity|p-hydroxybenzoic acid hydroxylase activity|4-hydroxybenzoate monooxygenase activity|p-hydroxybenzoic hydroxylase activity|p-hydroxybenzoate hydrolyase activity|p-hydroxybenzoate-3-hydroxylase activity|4-hydroxybenzoate 3-hydroxylase activity|p-hydroxybenzoate hydroxylase activity UM-BBD_reactionID:r0109|MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN|EC:1.14.13.2 molecular_function owl:Class
GO:0102618 biolink:NamedThing oryzalexin B synthase activity Catalysis of the reaction: oryzalexin D + NAD(P) <=> oryzalexin B + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-15466 molecular_function owl:Class
GO:0102828 biolink:NamedThing stachyose galactinol:verbascose galactosyltransferase activity Catalysis of the reaction: stachyose + alpha-D-galactosyl-(1->3)-1D-myo-inositol <=> verbascose + myo-inositol. got7fsn_ti MetaCyc:RXN-8284 molecular_function owl:Class
GO:0055012 biolink:NamedThing ventricular cardiac muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ. got7fsn_ti ventricular heart muscle cell differentiation|ventricular cardiomyocyte differentiation biological_process owl:Class
GO:0070313 biolink:NamedThing RGS6-DNMT1-DMAP1 complex A protein complex formed by the association of RGS6, a negative regulator of heterotrimeric G protein signaling, with the DMAP1-Dnmt1 transcriptional repressor complex; in the complex, RGS6 inhibits the transcriptional repressor activity of DMAP1. got7fsn_ti cellular_component owl:Class
GO:0008679 biolink:NamedThing 2-hydroxy-3-oxopropionate reductase activity Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+. got7fsn_ti (R)-glycerate:NAD(P)+ oxidoreductase activity|tartronate semialdehyde reductase (NADPH) activity RHEA:18841|MetaCyc:TSA-REDUCT-RXN|EC:1.1.1.60 molecular_function owl:Class
GO:0009104 biolink:NamedThing lipopolysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. got7fsn_ti lipopolysaccharide breakdown|LPS catabolic process|lipopolysaccharide degradation|lipopolysaccharide catabolism biological_process owl:Class
GO:0034876 biolink:NamedThing isonicotinic acid hydrazide hydrolase activity Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine. got7fsn_ti UM-BBD_reactionID:r1336 molecular_function owl:Class
GO:0102738 biolink:NamedThing (gibberellin-14), 2-oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A14 + O2 + 2-oxoglutarate <=> gibberellin A37 + carbon dioxide + succinate. got7fsn_ti MetaCyc:RXN-7589 molecular_function owl:Class
GO:0046201 biolink:NamedThing cyanate biosynthetic process The chemical reactions and pathways resulting in the formation of cyanate, NCO-, the anion of cyanic acid. got7fsn_ti cyanate synthesis|cyanate anabolism|cyanate formation|cyanate biosynthesis biological_process owl:Class
GO:0019335 biolink:NamedThing 3-methylquinoline catabolic process The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring. got7fsn_ti 3-methylquinoline breakdown|3-methylquinoline degradation|3-methylquinoline catabolism MetaCyc:PWY-721 biological_process owl:Class
GO:0005144 biolink:NamedThing interleukin-13 receptor binding Binding to an interleukin-13 receptor. got7fsn_ti IL-13|interleukin-13 receptor ligand molecular_function owl:Class
GO:0097739 biolink:NamedThing negative regulation of ferrichrome biosynthetic process in response to iron Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus. got7fsn_ti pr 2016-10-18T17:00:24Z biological_process owl:Class
GO:1905569 biolink:NamedThing negative regulation of ferrichrome biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of ferrichrome biosynthetic process. got7fsn_ti down-regulation of ferrichrome anabolism|down-regulation of ferrichrome biosynthetic process|down regulation of ferrichrome formation|downregulation of ferrichrome formation|down regulation of ferrichrome biosynthetic process, peptide formation|negative regulation of ferrichrome biosynthetic process, peptide modification|inhibition of ferrichrome biosynthetic process, peptide formation|down regulation of ferrichrome anabolism|down-regulation of ferrichrome formation|negative regulation of ferrichrome synthesis|downregulation of ferrichrome biosynthesis|negative regulation of ferrichrome biosynthesis|inhibition of ferrichrome biosynthesis|down regulation of ferrichrome biosynthetic process|down regulation of ferrichrome biosynthetic process, peptide modification|inhibition of ferrichrome anabolism|downregulation of ferrichrome biosynthetic process|negative regulation of ferrichrome biosynthetic process, peptide formation|downregulation of ferrichrome biosynthetic process, peptide formation|down-regulation of ferrichrome synthesis|negative regulation of ferrichrome anabolism|inhibition of ferrichrome formation|down-regulation of ferrichrome biosynthetic process, peptide formation|inhibition of ferrichrome biosynthetic process|down regulation of ferrichrome synthesis|inhibition of ferrichrome biosynthetic process, peptide modification|negative regulation of ferrichrome formation|down-regulation of ferrichrome biosynthesis|inhibition of ferrichrome synthesis|down regulation of ferrichrome biosynthesis|downregulation of ferrichrome synthesis|down-regulation of ferrichrome biosynthetic process, peptide modification|downregulation of ferrichrome biosynthetic process, peptide modification|downregulation of ferrichrome anabolism pr 2016-10-18T14:49:08Z biological_process owl:Class
GO:0034945 biolink:NamedThing 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA. got7fsn_ti UM-BBD_reactionID:r0987|EC:2.3.1.- molecular_function owl:Class
GO:0102751 biolink:NamedThing UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + a glucosyl-glycogenin = (1,4-alpha-D-glucosyl)n-glucosyl glucogenin + UDP + H+. got7fsn_ti MetaCyc:RXN-7667|RHEA:56560|EC:2.4.1.186 molecular_function owl:Class
GO:0047015 biolink:NamedThing 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity Catalysis of the reaction: NAD+ + 2-methyl-3-hydroxybutyryl-CoA = NADH + H+ + 2-methylaceto-acetyl-CoA. got7fsn_ti 2-methyl-3-hydroxy-butyryl CoA dehydrogenase activity|2-methyl-3-hydroxybutyryl-CoA dehydrogenase activity|(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase activity|2-methyl-3-hydroxybutyryl coenzyme A dehydrogenase activity MetaCyc:1.1.1.178-RXN|RHEA:13281|EC:1.1.1.178 molecular_function owl:Class
GO:0106343 biolink:NamedThing glutarate dioxygenase activity Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2. got7fsn_ti hjd 2020-11-17T18:04:10Z EC:1.14.11.64|RHEA:13821 molecular_function owl:Class
GO:0090438 biolink:NamedThing camelliol C synthase activity Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C. got7fsn_ti (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, camelliol-C-forming) tb 2012-08-08T15:41:45Z molecular_function owl:Class
GO:0140682 biolink:NamedThing histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. got7fsn_ti histone H3K4me2 demethylase activity|histone H3K4me demethylase activity https://github.com/geneontology/go-ontology/issues/21089 pg 2021-07-08T15:45:22Z EC:1.14.99.66|RHEA:60244 molecular_function owl:Class
GO:0034690 biolink:NamedThing integrin alphaD-beta2 complex An integrin complex that comprises one alphaD subunit and one beta2 subunit. got7fsn_ti alphaD-beta2 integrin complex|Itgad-Itgb2 complex cellular_component owl:Class
GO:0103006 biolink:NamedThing 9,10-dihydroxystearate hydroxylase activity Catalysis of the reaction: H+ + (9R,10S)-dihydroxystearate + O2 + NADPH <=> 9,10,18-trihydroxystearate + H2O + NADP. got7fsn_ti MetaCyc:RXN-9807 molecular_function owl:Class
GO:0019579 biolink:NamedThing aldaric acid catabolic process The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group. got7fsn_ti aldaric acid degradation|aldaric acid breakdown|aldaric acid catabolism biological_process owl:Class
GO:0021617 biolink:NamedThing glossopharyngeal nerve structural organization The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion. got7fsn_ti CN IX structural organization|glossopharyngeal nerve structural organisation biological_process owl:Class
GO:0047344 biolink:NamedThing glucose-1-phosphate guanylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + GTP = diphosphate + GDP-D-glucose. got7fsn_ti GDP-glucose pyrophosphorylase activity|GTP:glucose-1-phosphate guanylyltransferase activity|GDP glucose pyrophosphorylase activity|GDP-glucose diphosphorylase activity|GTP:alpha-D-glucose-1-phosphate guanylyltransferase activity|guanosine diphosphoglucose pyrophosphorylase activity RHEA:10708|KEGG_REACTION:R00954|EC:2.7.7.34|MetaCyc:2.7.7.34-RXN molecular_function owl:Class
GO:0031042 biolink:NamedThing O-glycan processing, core 6 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc. got7fsn_ti biological_process owl:Class
GO:0018081 biolink:NamedThing peptide cross-linking via lanthionine or 3-methyl-lanthionine The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process. got7fsn_ti peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine|peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine RESID:AA0111|RESID:AA0110|RESID:AA0112 biological_process owl:Class
GO:0047059 biolink:NamedThing polyvinyl alcohol dehydrogenase (cytochrome) activity Catalysis of the reaction: polyvinyl alcohol + ferricytochrome c = oxidized polyvinyl alcohol + ferrocytochrome c + H+. got7fsn_ti PVA dehydrogenase activity|polyvinyl alcohol:ferricytochrome-c oxidoreductase activity|polyvinyl-alcohol:(acceptor) oxidoreductase activity|polyvinyl-alcohol:acceptor oxidoreductase activity Formerly EC:1.1.99.23. EC:1.1.2.6|KEGG_REACTION:R03136|MetaCyc:RXN-11316|RHEA:20157 molecular_function owl:Class
GO:0003131 biolink:NamedThing mesodermal-endodermal cell signaling Any process that mediates the transfer of information from mesodermal cells to endodermal cells. got7fsn_ti mesodermal-endodermal cell signalling tb 2009-09-22T03:07:34Z biological_process owl:Class
GO:0031083 biolink:NamedThing BLOC-1 complex A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins. got7fsn_ti cellular_component owl:Class
GO:0097255 biolink:NamedThing R2TP complex A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. got7fsn_ti pr 2012-03-06T11:16:33Z cellular_component owl:Class
GO:0050030 biolink:NamedThing L-pipecolate dehydrogenase activity Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. got7fsn_ti L-pipecolate:(acceptor) 1,6-oxidoreductase activity|L-pipecolate:acceptor 1,6-oxidoreductase activity MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN|EC:1.5.99.3|RHEA:19777 molecular_function owl:Class
GO:0047959 biolink:NamedThing glycine dehydrogenase (cytochrome) activity Catalysis of the reaction: glycine + H2O + 2 ferricytochrome c = glyoxylate + NH3 + 2 ferrocytochrome c. got7fsn_ti glycine-cytochrome c reductase activity|glycine:ferricytochrome-c oxidoreductase (deaminating)|reductase, glycine-cytochrome c RHEA:16909|MetaCyc:GLYCINE-DEHYDROGENASE-CYTOCHROME-RXN|EC:1.4.2.1 molecular_function owl:Class
GO:0034836 biolink:NamedThing 6-hydroxy-2-mercaptobenzothiazole monooxygenase activity Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole. got7fsn_ti UM-BBD_reactionID:r1181|EC:1.13.12.- molecular_function owl:Class
GO:0016155 biolink:NamedThing formyltetrahydrofolate dehydrogenase activity Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH. got7fsn_ti 10-formyl-H4folate dehydrogenase activity|10-formyl-H2PtGlu:NADP oxidoreductase activity|10-formyltetrahydrofolate dehydrogenase activity|10-formyl tetrahydrofolate:NADP oxidoreductase activity|10-formyltetrahydrofolate:NADP+ oxidoreductase activity|N10-formyltetrahydrofolate dehydrogenase activity RHEA:10180|EC:1.5.1.6|KEGG_REACTION:R00941|MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0004304 biolink:NamedThing estrone sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate. got7fsn_ti 3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity|estrogen sulfotransferase|estrogen sulphotransferase activity|3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity|estrone sulphotransferase activity|3'-phosphoadenylylsulfate:oestrone sulfotransferase activity|oestrogen sulphotransferase activity EC:2.8.2.4|RHEA:15973|MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN|Reactome:R-HSA-176664 molecular_function owl:Class
GO:0070617 biolink:NamedThing negative regulation of thiamine diphosphate biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine diphosphate. got7fsn_ti negative regulation of thiamine diphosphate synthesis|down regulation of thiamine diphosphate biosynthetic process|inhibition of thiamine diphosphate biosynthetic process|negative regulation of thiamine diphosphate anabolism|downregulation of thiamine diphosphate biosynthetic process|negative regulation of thiamin diphosphate biosynthetic process|negative regulation of thiamine diphosphate biosynthesis|down-regulation of thiamine diphosphate biosynthetic process|negative regulation of thiamine diphosphate formation mah 2009-04-29T03:39:48Z biological_process owl:Class
GO:0060045 biolink:NamedThing positive regulation of cardiac muscle cell proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation. got7fsn_ti positive regulation of heart muscle cell proliferation biological_process owl:Class
GO:0030909 biolink:NamedThing non-intein-mediated protein splicing The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins. got7fsn_ti biological_process owl:Class
GO:0033818 biolink:NamedThing beta-ketoacyl-acyl-carrier-protein synthase III activity Catalysis of the reaction: acetyl-CoA + malonyl-[acyl-carrier protein] = acetoacyl-[acyl-carrier protein] + CoA + CO2. got7fsn_ti beta-ketoacyl-ACP synthase III activity|acetyl-CoA:malonyl-acyl-carrier-protein C-acyltransferase activity|KAS III|beta-ketoacyl (acyl carrier protein) synthase III activity|3-ketoacyl-acyl carrier protein synthase III activity|KASIII|FabH|beta-ketoacyl-acyl carrier protein synthase III activity|3-oxoacyl:ACP synthase III activity RHEA:12080|MetaCyc:2.3.1.180-RXN|EC:2.3.1.180 molecular_function owl:Class
GO:0036181 biolink:NamedThing protein localization to linear element A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. got7fsn_ti protein localisation to linear element bf 2012-03-30T04:14:17Z biological_process owl:Class
GO:0043176 biolink:NamedThing amine binding Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group. got7fsn_ti molecular_function owl:Class
GO:0044586 biolink:NamedThing cellotetraose binding Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose. got7fsn_ti jl 2012-04-24T04:56:10Z molecular_function owl:Class
GO:0034923 biolink:NamedThing phenanthrene-4,5-dicarboxylate decarboxylase activity Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2. got7fsn_ti UM-BBD_reactionID:r0937 molecular_function owl:Class
GO:0048292 biolink:NamedThing isotype switching to IgD isotypes The switching of activated B cells from IgM biosynthesis to IgD biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgD constant region gene segments in the immunoglobulin heavy chain locus. got7fsn_ti isotype switch recombination to IgD isotypes|class switching to IgD isotypes Note that this term is to be used only for gene products involved in the expression of IgD through recombinational switching into the vestigial switch region at the 5' end of the IgD gene segment, rather than gene products involved in the expression of IgD through alternative splicing mechanisms. biological_process owl:Class
GO:0016154 biolink:NamedThing pyrimidine-nucleoside phosphorylase activity Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate. got7fsn_ti Py-NPase activity|pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN|EC:2.4.2.2 molecular_function owl:Class
GO:0010057 biolink:NamedThing trichoblast fate specification The process involved in the specification of a trichoblast. got7fsn_ti biological_process owl:Class
GO:0097126 biolink:NamedThing cyclin B2-CDK1 complex A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:46:17Z cellular_component owl:Class
GO:0047088 biolink:NamedThing dihydrosanguinarine 10-monooxygenase activity Catalysis of the reaction: dihydrosanguinarine + H(+) + NADPH + O(2) = 10-hydroxydihydrosanguinarine + H(2)O + NADP(+). got7fsn_ti dihydrosanguinarine,NADPH:oxygen oxidoreductase (10-hydroxylating)|dihydrosanguinarine 10-hydroxylase activity EC:1.14.14.100|KEGG_REACTION:R04702|RHEA:10528|MetaCyc:1.14.13.56-RXN molecular_function owl:Class
GO:0018583 biolink:NamedThing biphenyl-2,3-diol 1,2-dioxygenase activity Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O. got7fsn_ti 2,3-dihydroxybiphenyl dioxygenase activity|biphenyl-2,3-diol dioxygenase activity|2,3-dihydroxybiphenyl 1,2-dioxygenase activity|biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing) RHEA:14413|EC:1.13.11.39|MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN|UM-BBD_enzymeID:e0127 molecular_function owl:Class
GO:0007638 biolink:NamedThing mechanosensory behavior Behavior that is dependent upon the sensation of a mechanical stimulus. got7fsn_ti mechanosensory behaviour|behavioral response to mechanical stimulus|behavioural response to mechanical stimulus biological_process owl:Class
GO:0045131 biolink:NamedThing pre-mRNA branch point binding Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site. got7fsn_ti molecular_function owl:Class
GO:0050593 biolink:NamedThing N-methylcoclaurine 3'-monooxygenase activity Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+). got7fsn_ti (S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (3'-hydroxylating)|cytochrome P450 80B1 activity|(S)-N-methylcoclaurine 3'-hydroxylase activity|N-methylcoclaurine 3'-hydroxylase activity MetaCyc:1.14.13.71-RXN|RHEA:16649|EC:1.14.14.102|KEGG_REACTION:R05732 molecular_function owl:Class
GO:0039606 biolink:NamedThing suppression by virus of host translation initiation Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein. got7fsn_ti bf 2012-07-05T04:44:10Z biological_process owl:Class
GO:0016012 biolink:NamedThing sarcoglycan complex A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex. got7fsn_ti sarcoglycan-sarcospan complex cellular_component owl:Class
GO:0023002 biolink:NamedThing nuclear migration to embryo sac poles Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell. got7fsn_ti nucleus migration to megagametophyte poles|nucleus migration to embryo sac poles|nucleus migration to female gametophyte poles|nuclear migration to megagametophyte poles|nuclear migration to female gametophyte poles biological_process owl:Class
GO:1902728 biolink:NamedThing positive regulation of growth factor dependent skeletal muscle satellite cell proliferation Any process that activates or increases the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta. got7fsn_ti mr 2014-02-24T16:10:33Z biological_process owl:Class
GO:1902724 biolink:NamedThing positive regulation of skeletal muscle satellite cell proliferation Any process that activates or increases the frequency, rate or extent of skeletal muscle satellite cell proliferation. got7fsn_ti up regulation of satellite cell proliferation|up-regulation of satellite cell proliferation|upregulation of satellite cell proliferation|activation of satellite cell proliferation mr 2014-02-24T16:09:56Z biological_process owl:Class
GO:0090449 biolink:NamedThing phloem glucosinolate loading The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink. got7fsn_ti tb 2012-09-07T16:21:22Z biological_process owl:Class
GO:1901349 biolink:NamedThing glucosinolate transport The directed movement of a glucosinolate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti tb 2012-09-07T22:44:34Z biological_process owl:Class
GO:0009990 biolink:NamedThing contact guidance Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells. got7fsn_ti biological_process owl:Class
GO:0008362 biolink:NamedThing chitin-based embryonic cuticle biosynthetic process Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster. got7fsn_ti embryonic cuticle biosynthetic process|embryonic cuticle synthesis|embryonic cuticle formation|embryonic cuticle anabolism biological_process owl:Class
GO:0015955 biolink:NamedThing pyrimidine deoxyribonucleotide interconversion The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide. got7fsn_ti biological_process owl:Class
GO:0009219 biolink:NamedThing pyrimidine deoxyribonucleotide metabolic process The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti pyrimidine deoxyribonucleotide metabolism biological_process owl:Class
GO:0140692 biolink:NamedThing very long-chain fatty acid omega-hydroxylase activity Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced [NADPH-hemoprotein reductase] = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized [NADPH-hemoprotein reductase]. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21925 pg 2021-08-05T07:41:17Z molecular_function owl:Class
GO:0070242 biolink:NamedThing thymocyte apoptotic process Any apoptotic process in a thymocyte, an immature T cell located in the thymus. got7fsn_ti thymocyte apoptosis|immature T cell apoptosis Note that a thymocyte is an immature T cell located in the thymus (CL:0000893). biological_process owl:Class
GO:0045720 biolink:NamedThing negative regulation of integrin biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins. got7fsn_ti inhibition of integrin biosynthetic process|negative regulation of integrin biosynthesis|down regulation of integrin biosynthetic process|down-regulation of integrin biosynthetic process|downregulation of integrin biosynthetic process|negative regulation of integrin anabolism|negative regulation of integrin synthesis|negative regulation of integrin formation biological_process owl:Class
GO:0042500 biolink:NamedThing aspartic endopeptidase activity, intramembrane cleaving Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. got7fsn_ti Note that although GO generally avoids the use of localization information in terms, in this case an exception was made. This is because the fact that the cleavage occurs within the membrane is integral to its function, as it is the only thing that distinguishes this group from other aspartic endopeptidases. EC:3.4.23.-|Reactome:R-HSA-8863101 molecular_function owl:Class
GO:0070371 biolink:NamedThing ERK1 and ERK2 cascade An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. got7fsn_ti ERK1 and ERK2 signalling pathway|ERK1 cascade|MAPK1 cascade|ERK cascade|ERK2 cascade|MAPK3 cascade|extracellular signal-regulated kinase 1/2 cascade|extracellular signal-regulated kinase 1/2 (ERK1/2) cascade|ERK1 and ERK2 signaling pathway|ERK1/2 cascade Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2 and should not be confused with cascades that involve other ERK kinases. biological_process owl:Class
GO:0022023 biolink:NamedThing radial glial cell fate commitment in forebrain The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain. got7fsn_ti biological_process owl:Class
GO:0102834 biolink:NamedThing 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity Catalysis of the reaction: 1-18:1-2-16:0-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.23|MetaCyc:RXN-8294 molecular_function owl:Class
GO:0047390 biolink:NamedThing glycerophosphocholine cholinephosphodiesterase activity Catalysis of the reaction: sn-glycero-3-phosphocholine + H(2)O = choline phosphate + glycerol + H(+). got7fsn_ti L-3-glycerylphosphinicocholine cholinephosphohydrolase activity|sn-glycero-3-phosphocholine cholinephosphohydrolase activity RHEA:19545|Reactome:R-HSA-6814797|KEGG_REACTION:R02591|EC:3.1.4.38|MetaCyc:3.1.4.38-RXN molecular_function owl:Class
GO:0043024 biolink:NamedThing ribosomal small subunit binding Binding to a small ribosomal subunit. got7fsn_ti molecular_function owl:Class
GO:0034710 biolink:NamedThing inhibin complex binding Binding to an inhibin complex, a dimer of one inhibin-alpha subunit and one inhibin-beta subunit. got7fsn_ti molecular_function owl:Class
GO:0043522 biolink:NamedThing leucine zipper domain binding Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. got7fsn_ti leucine zipper binding molecular_function owl:Class
GO:0050464 biolink:NamedThing nitrate reductase (NADPH) activity Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+. got7fsn_ti NADPH-nitrate reductase activity|nitrate reductase (NADPH2)|triphosphopyridine nucleotide-nitrate reductase activity|NADPH:nitrate reductase activity|NADPH:nitrate oxidoreductase activity|assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase activity|nitrate reductase (NADPH(2)) activity|assimilatory nitrate reductase activity|assimilatory NADPH-nitrate reductase activity|nitrite:NADP+ oxidoreductase activity EC:1.7.1.3|RHEA:19061|MetaCyc:NITRATE-REDUCTASE-NADPH-RXN molecular_function owl:Class
GO:0052580 biolink:NamedThing (+)-pulegone reductase, (-)-menthone as substrate, activity Catalysis of the reaction: (-)-menthone + NADP+ = (+)-pulegone + NADPH + H+. got7fsn_ti (-)-menthone:NADP+ oxidoreductase activity ai 2010-08-09T04:33:53Z EC:1.3.1.81|MetaCyc:RXN-5164 molecular_function owl:Class
GO:0005248 biolink:NamedThing voltage-gated sodium channel activity Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage gated sodium channel activity|voltage-sensitive sodium channel|voltage-gated sodium ion channel activity|voltage-dependent sodium channel activity Reactome:R-HSA-5576895 molecular_function owl:Class
GO:0005272 biolink:NamedThing sodium channel activity Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. got7fsn_ti Reactome:R-HSA-3295580|Reactome:R-HSA-2730664 molecular_function owl:Class
GO:0008116 biolink:NamedThing prostaglandin-I synthase activity Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2). got7fsn_ti prostacycline synthetase activity|PGI(2) synthetase activity|cytochrome P450 CYP8A1|PGI2 synthetase activity|PGI(2) synthase activity|(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity|prostacyclin synthase activity|PGI2 synthase activity|prostagladin I2 synthetase activity Reactome:R-HSA-76496|KEGG_REACTION:R02267|MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN|EC:5.3.99.4|RHEA:23580 molecular_function owl:Class
GO:0043799 biolink:NamedThing glycine oxidase activity Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide. got7fsn_ti glycine:oxygen oxidoreductase (deaminating) MetaCyc:RXN-8672|EC:1.4.3.19|MetaCyc:1.4.3.19-RXN|MetaCyc:RXN-8674|MetaCyc:RXN-8673 molecular_function owl:Class
GO:0071601 biolink:NamedThing sphere organelle A nuclear body that is found in the germinal vesicles of amphibian oocytes, and consist of three major parts: a remarkably spherical body about 5-10 pm in diameter, smaller spherical or nearly spherical granules on the surface, and inclusions of various sizes that strongly resemble the surface granules. The parts of the sphere organelle have distinct compositions, including splicing snRNAs and proteins. got7fsn_ti mah 2010-02-04T04:26:41Z cellular_component owl:Class
GO:0008806 biolink:NamedThing carboxymethylenebutenolidase activity Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate. got7fsn_ti maleylacetate enol-lactonase activity|4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity|carboxymethylene butenolide hydrolase activity|dienelactone hydrolase activity GO:0018735 RHEA:12372|EC:3.1.1.45|UM-BBD_enzymeID:e0066|MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN molecular_function owl:Class
GO:0003118 biolink:NamedThing regulation of vasoconstriction by neuronal norepinephrine Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings. got7fsn_ti regulation of vasoconstriction by neuronal noradrenaline biological_process owl:Class
GO:0008660 biolink:NamedThing 1-aminocyclopropane-1-carboxylate deaminase activity Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+). got7fsn_ti 1-aminocyclopropane carboxylic acid deaminase activity|1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity|ACC deaminase activity|1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing) Note that this function was formerly EC:4.1.99.4. GO:0018806 UM-BBD_reactionID:r0357|EC:3.5.99.7|MetaCyc:4.1.99.4-RXN|RHEA:16933|KEGG_REACTION:R00997 molecular_function owl:Class
GO:0035746 biolink:NamedThing granzyme A production The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. bf 2011-03-17T02:39:11Z biological_process owl:Class
GO:0047589 biolink:NamedThing 5-aminovalerate transaminase activity Catalysis of the reaction: 2-oxoglutarate + 5-aminopentanoate = 5-oxopentanoate + L-glutamate. got7fsn_ti delta-aminovalerate transaminase activity|5-aminopentanoate:2-oxoglutarate aminotransferase activity|delta-aminovalerate aminotransferase activity|5-aminovalerate aminotransferase activity RHEA:10212|MetaCyc:VAGL-RXN|EC:2.6.1.48|KEGG_REACTION:R02274 molecular_function owl:Class
GO:0090614 biolink:NamedThing 5'-methylthioadenosine deaminase activity Catalysis of the reaction: 5'methyl thioadenosine + H2O = 5'methyl thioinosine + NH3. got7fsn_ti tb 2014-10-23T15:59:38Z RHEA:25025|EC:3.5.4.31 molecular_function owl:Class
GO:0060772 biolink:NamedThing leaf phyllotactic patterning The radial pattern formation process that results in the formation of leaf primordia around the center of a shoot apical meristem. got7fsn_ti dph 2009-07-25T06:27:15Z biological_process owl:Class
GO:0018835 biolink:NamedThing carbon phosphorus lyase activity Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate). got7fsn_ti GO:0009456 EC:4.7.1.- molecular_function owl:Class
GO:0036300 biolink:NamedThing B cell receptor internalization A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell. got7fsn_ti BCR receptor internalization|B cell receptor uptake of antigen|BCR endocytosis bf 2012-08-07T11:24:20Z biological_process owl:Class
GO:1902794 biolink:NamedThing heterochromatin island assembly The aggregation, arrangement and bonding together of a set of components to form a heterochromatin island. got7fsn_ti heterochromatin island formation mah 2014-03-24T12:46:49Z biological_process owl:Class
GO:0051796 biolink:NamedThing negative regulation of timing of catagen Any process that stops, prevents, or reduces the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. got7fsn_ti negative regulation of catagen|inhibition of catagen|down regulation of catagen|down-regulation of catagen|downregulation of catagen biological_process owl:Class
GO:0102854 biolink:NamedThing 1-18:2-2-18:1-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:1-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8321 molecular_function owl:Class
GO:0018233 biolink:NamedThing peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link. got7fsn_ti RESID:AA0109 biological_process owl:Class
GO:0097519 biolink:NamedThing DNA recombinase complex A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA. got7fsn_ti pr 2013-10-16T15:43:22Z cellular_component owl:Class
GO:0070640 biolink:NamedThing vitamin D3 metabolic process The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol. got7fsn_ti cholecalciferol metabolic process|vitamin D3 metabolism|calciol metabolic process mah 2009-05-08T02:24:24Z biological_process owl:Class
GO:0000001 biolink:NamedThing mitochondrion inheritance The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton. got7fsn_ti mitochondrial inheritance biological_process owl:Class
GO:0002278 biolink:NamedThing eosinophil activation involved in immune response The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. got7fsn_ti eosinophil activation during immune response biological_process owl:Class
GO:0019920 biolink:NamedThing peptidyl-1-thioglycine biosynthetic process, internal The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide. got7fsn_ti peptidyl-1-thioglycine formation, internal|peptidyl-1-thioglycine anabolism, internal|peptidyl-1-thioglycine synthesis, internal RESID:AA0265 biological_process owl:Class
GO:0098715 biolink:NamedThing malonic acid import across plasma membrane The directed movement of malonic acid from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti malonate import into cell|malonic acid import into cell pr 2012-10-30T15:33:37Z GO:0097406 biological_process owl:Class
GO:0043115 biolink:NamedThing precorrin-2 dehydrogenase activity Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin. got7fsn_ti dihydrosirohydrochlorin dehydrogenase activity|CysG|precorrin-2:NAD+ oxidoreductase activity|1,3-dimethyluroporphyrinogen III dehydrogenase activity|Met8p|precorrin-2 oxidase activity|siroheme synthase activity|SirC KEGG_REACTION:R03947|MetaCyc:DIMETHUROPORDEHYDROG-RXN|EC:1.3.1.76|RHEA:15613 molecular_function owl:Class
GO:0034846 biolink:NamedThing naphthyl-2-methylene-succinyl-CoA lyase activity Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA. got7fsn_ti UM-BBD_reactionID:r1259 molecular_function owl:Class
GO:0008965 biolink:NamedThing phosphoenolpyruvate-protein phosphotransferase activity Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. got7fsn_ti enzyme I of the phosphotransferase system|phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity|phosphopyruvate--protein factor phosphotransferase activity|phosphopyruvate--protein phosphotransferase activity|phosphoenolpyruvate--protein phosphatase activity|phosphoenolpyruvate sugar phosphotransferase enzyme I activity|sugar--PEP phosphotransferase enzyme I activity|phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity EC:2.7.3.9|MetaCyc:2.7.3.9-RXN|RHEA:23880 molecular_function owl:Class
GO:0061594 biolink:NamedThing 6-deoxy-6-sulfofructose kinase activity Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP. got7fsn_ti dph 2014-02-10T09:59:26Z EC:2.7.1.184|MetaCyc:RXN-15297|RHEA:40443 molecular_function owl:Class
GO:0031213 biolink:NamedThing RSF complex An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters). got7fsn_ti remodeling and spacing factor complex cellular_component owl:Class
GO:0033848 biolink:NamedThing N2-(2-carboxyethyl)arginine synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + L-arginine = N(2)-(2-carboxyethyl)-L-arginine + H(+) + phosphate. got7fsn_ti glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity|CEAS|CEA synthetase activity|N2-(2-carboxyethyl)arginine synthetase activity|glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming) activity EC:2.5.1.66|KEGG_REACTION:R05465|RHEA:10556|MetaCyc:2.5.1.66-RXN molecular_function owl:Class
GO:0050473 biolink:NamedThing arachidonate 15-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate. got7fsn_ti arachidonate omega(6) lipoxygenase activity|linoleic acid omega6-lipoxygenase activity|arachidonate:oxygen 15-oxidoreductase activity|omega6 lipoxygenase activity|15-lipoxygenase activity|arachidonate omega6 lipoxygenase activity Reactome:R-HSA-9028255|EC:1.13.11.33|Reactome:R-HSA-9027607|Reactome:R-HSA-9018907|MetaCyc:ARACHIDONATE-15-LIPOXYGENASE-RXN|Reactome:R-HSA-9024881|Reactome:R-HSA-9020610|Reactome:R-HSA-9020262|Reactome:R-HSA-9025152|Reactome:R-HSA-9027532|Reactome:R-HSA-9027627|RHEA:16869|Reactome:R-HSA-9020275|Reactome:R-HSA-9026003|Reactome:R-HSA-9024872|Reactome:R-HSA-9020261|Reactome:R-HSA-2161951|Reactome:R-HSA-2162002 molecular_function owl:Class
GO:0030769 biolink:NamedThing macrocin O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin. got7fsn_ti macrocin methyltransferase activity|S-adenosyl-L-methionine-macrocin O-methyltransferase activity|S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity KEGG_REACTION:R02858|RHEA:17269|EC:2.1.1.101|MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0106360 biolink:NamedThing 2-hydroxy-3-methylhexadecanoyl-CoA lyase activity Catalysis of the reaction: 2-hydroxy-3-methylhexadecanoyl-CoA = 2-methylpentadecanal + formyl-CoA. got7fsn_ti hjd 2021-02-03T16:14:49Z RHEA:25379 molecular_function owl:Class
GO:0050171 biolink:NamedThing phenol beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside. got7fsn_ti UDP glucosyltransferase activity|phenol-beta-D-glucosyltransferase activity|uridine diphosphoglucosyltransferase activity|phenol b-glucosyltransferase activity|UDPglucose:phenol beta-D-glucosyltransferase activity|UDP-glucose glucosyltransferase activity|UDPglucosyltransferase activity|UDP-glucose:phenol beta-D-glucosyltransferase activity EC:2.4.1.35|MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0010737 biolink:NamedThing protein kinase A signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. got7fsn_ti PKA signaling cascade|protein kinase A signalling cascade|protein kinase A signal transduction|protein kinase A signaling cascade biological_process owl:Class
GO:0021958 biolink:NamedThing gracilis tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb. got7fsn_ti tract of Goll morphogenesis biological_process owl:Class
GO:0036160 biolink:NamedThing melanocyte-stimulating hormone secretion The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation. got7fsn_ti MSH secretion bf 2012-03-26T01:16:55Z biological_process owl:Class
GO:0120220 biolink:NamedThing basal body patch The region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster. got7fsn_ti centriolar patch krc 2019-11-15T17:19:24Z cellular_component owl:Class
GO:0045434 biolink:NamedThing negative regulation of female receptivity, post-mating Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating. got7fsn_ti downregulation of female receptivity, post-mating|down regulation of female receptivity, post-mating|down-regulation of female receptivity, post-mating|inhibition of female receptivity, post-mating biological_process owl:Class
GO:0009514 biolink:NamedThing glyoxysome A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds. got7fsn_ti Wikipedia:Glyoxysome cellular_component owl:Class
GO:0050238 biolink:NamedThing pyridoxine 5-dehydrogenase activity Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor. got7fsn_ti pyridoxal-5-dehydrogenase activity|pyridoxine:acceptor 5-oxidoreductase activity|pyridoxin 5-dehydrogenase activity|pyridoxol 5-dehydrogenase activity|pyridoxine 5'-dehydrogenase activity|pyridoxine:(acceptor) 5-oxidoreductase activity EC:1.1.99.9|RHEA:14497|MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0017065 biolink:NamedThing single-strand selective uracil DNA N-glycosylase activity Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA. got7fsn_ti single-strand selective monofunctional uracil-DNA glycosylase activity Reactome:R-HSA-110221 molecular_function owl:Class
GO:0042116 biolink:NamedThing macrophage activation A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti macrophage polarization biological_process owl:Class
GO:0002936 biolink:NamedThing bradykinin biosynthetic process The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin. got7fsn_ti hjd 2012-10-17T14:24:24Z biological_process owl:Class
GO:0000389 biolink:NamedThing mRNA 3'-splice site recognition Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome. got7fsn_ti U12-type nuclear mRNA 3'-splice site recognition|nuclear mRNA 3'-splice site recognition|U2-type nuclear mRNA 3'-splice site recognition GO:0000382|GO:0000383 biological_process owl:Class
GO:0005599 biolink:NamedThing collagen type X trimer A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets). got7fsn_ti Collagen X trimers have been observed to form hexagonal lattices in vitro, but in vivo they have been found in a fibril associated form (PMID:19693541). cellular_component owl:Class
GO:0102126 biolink:NamedThing coniferyl aldehyde 5-hydroxylase activity Catalysis of the reaction: H+ + coniferyl aldehyde + NADPH + O2 <=> 5-hydroxy-coniferaldehyde + NADP + H2O. got7fsn_ti MetaCyc:RXN-1142 molecular_function owl:Class
GO:0036141 biolink:NamedThing L-phenylalanine-oxaloacetate transaminase activity Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate. got7fsn_ti L-phenylalanine:oxaloacetate transaminase activity bf 2012-03-08T10:35:44Z molecular_function owl:Class
GO:0071056 biolink:NamedThing alpha9-beta1 integrin-ADAM15 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM15. got7fsn_ti ITGA9-ITGB1-ADAM15 complex mah 2009-11-03T03:59:49Z cellular_component owl:Class
GO:0018785 biolink:NamedThing haloacetate dehalogenase activity Catalysis of the reaction: haloacetate + H2O = glycolate + halide. got7fsn_ti haloacetate halidohydrolase activity|monohaloacetate dehalogenase activity UM-BBD_enzymeID:e0006|EC:3.8.1.3|MetaCyc:HALOACETATE-DEHALOGENASE-RXN|RHEA:11044 molecular_function owl:Class
GO:0102737 biolink:NamedThing p-coumaroyltriacetic acid synthase activity Catalysis of the reaction: 2 H+ + 4-coumaryl-CoA + H2O + 3 malonyl-CoA <=> 4 coenzyme A + 3 carbon dioxide + p-coumaroyltriacetate. got7fsn_ti MetaCyc:RXN-7577 molecular_function owl:Class
GO:0071613 biolink:NamedThing granzyme B production The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. mah 2010-02-05T04:47:15Z biological_process owl:Class
GO:0003017 biolink:NamedThing lymph circulation The flow of lymph through the body of an animal. got7fsn_ti biological_process owl:Class
GO:0009290 biolink:NamedThing DNA import into cell involved in transformation The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell. got7fsn_ti DNA transport into cell during transformation|cellular DNA uptake|DNA import into cell involved in transformation|DNA import into cell|cellular DNA import during transformation biological_process owl:Class
GO:0033450 biolink:NamedThing GUC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GUC codon. got7fsn_ti valine tRNA|GTC codon-amino acid adaptor activity Note that in the standard genetic code, GTC codes for valine. molecular_function owl:Class
GO:0102593 biolink:NamedThing UDP-glucose: N-methylanthranilate glucosyltransferase activity Catalysis of the reaction: N-methylanthranilate + UDP-alpha-D-glucose = N-methylanthraniloyl-beta-D-glucopyranose + UDP. got7fsn_ti MetaCyc:RXN-15371 molecular_function owl:Class
GO:0036057 biolink:NamedThing slit diaphragm A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. got7fsn_ti bf 2011-12-12T04:36:42Z cellular_component owl:Class
GO:0102343 biolink:NamedThing 3-hydroxy-arachidoyl-CoA dehydratase activity Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA <=> trans-2-icosenoyl-CoA + H2O. got7fsn_ti EC:4.2.1.134|MetaCyc:RXN-13302 molecular_function owl:Class
GO:0050383 biolink:NamedThing uracil dehydrogenase activity Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor. got7fsn_ti RHEA:22752|MetaCyc:URACIL-DEHYDROGENASE-RXN|EC:1.17.99.4 molecular_function owl:Class
GO:0103033 biolink:NamedThing beta-galactosidase activity (lactose isomerization) Catalysis of the reaction: alpha-lactose = beta-(1->6)-galactobiose. got7fsn_ti MetaCyc:RXN0-5363 molecular_function owl:Class
GO:0031526 biolink:NamedThing brush border membrane The portion of the plasma membrane surrounding the brush border. got7fsn_ti cellular_component owl:Class
GO:0047395 biolink:NamedThing glycerophosphoinositol glycerophosphodiesterase activity Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = sn-glycerol 3-phosphate + myo-inositol + H(+). got7fsn_ti 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase activity|sn-glycero-3-phospho-1-inositol glycerophosphohydrolase activity|sn-glycero(3)phosphoinositol glycerophosphohydrolase activity MetaCyc:3.1.4.44-RXN|KEGG_REACTION:R01193|RHEA:16501|EC:3.1.4.44|Reactome:R-HSA-6813740 molecular_function owl:Class
GO:0018687 biolink:NamedThing biphenyl 2,3-dioxygenase activity Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+. got7fsn_ti biphenyl dioxygenase activity|biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating) RHEA:18165|UM-BBD_enzymeID:e0089|MetaCyc:1.14.12.18-RXN|EC:1.14.12.18 molecular_function owl:Class
GO:0050031 biolink:NamedThing L-pipecolate oxidase activity Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate. got7fsn_ti L-pipecolic acid oxidase activity|L-pipecolate:oxygen 1,6-oxidoreductase activity EC:1.5.3.7|MetaCyc:L-PIPECOLATE-OXIDASE-RXN|RHEA:11992|Reactome:R-HSA-6783880|KEGG_REACTION:R02204 molecular_function owl:Class
GO:0001665 biolink:NamedThing alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. got7fsn_ti CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity|GalNAc alpha-2,6-sialyltransferase I activity RHEA:11136|EC:2.4.99.3|MetaCyc:2.4.99.3-RXN|Reactome:R-HSA-9603991|Reactome:R-HSA-4084980 molecular_function owl:Class
GO:0050942 biolink:NamedThing positive regulation of pigment cell differentiation Any process that activates or increases the frequency, rate or extent of pigment cell differentiation. got7fsn_ti up regulation of pigment cell differentiation|stimulation of pigment cell differentiation|up-regulation of pigment cell differentiation|activation of pigment cell differentiation|upregulation of pigment cell differentiation biological_process owl:Class
GO:0048087 biolink:NamedThing positive regulation of developmental pigmentation Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism. got7fsn_ti stimulation of developmental pigmentation|upregulation of developmental pigmentation|activation of developmental pigmentation|up regulation of developmental pigmentation|up-regulation of developmental pigmentation biological_process owl:Class
GO:0045114 biolink:NamedThing beta 2 integrin biosynthetic process The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit. got7fsn_ti beta 2 integrin synthesis|beta 2 integrin formation|beta 2 integrin anabolism|beta 2 integrin biosynthesis biological_process owl:Class
GO:0052862 biolink:NamedThing glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. got7fsn_ti laminarinase activity|laminaranase activity|1,3-(1,4)-beta-D-glucan 4-glucanohydrolase activity ai 2011-12-06T05:27:26Z EC:3.2.1.6|MetaCyc:3.2.1.6-RXN molecular_function owl:Class
GO:0019179 biolink:NamedThing dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate. got7fsn_ti thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity|thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity|thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity|dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity|dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity|TDP-4-oxo-6-deoxy-D-glucose transaminase activity|thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity|TDP-4-keto-6-deoxy-D-glucose transaminase activity MetaCyc:2.6.1.33-RXN|RHEA:19085|EC:2.6.1.33 molecular_function owl:Class
GO:0070204 biolink:NamedThing 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Catalysis of the reaction: 2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2). got7fsn_ti MenD|SEPHCHC synthase activity Note that this function was formerly EC:4.1.3.18. KEGG_REACTION:R08165|MetaCyc:2.5.1.64-RXN|RHEA:25593|EC:2.2.1.9 molecular_function owl:Class
GO:0019488 biolink:NamedThing ribitol catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate. got7fsn_ti ribitol utilization|ribitol degradation to xylulose 5-phosphate|ribitol breakdown to xylulose 5-phosphate MetaCyc:RIBITOLUTIL-PWY biological_process owl:Class
GO:0050111 biolink:NamedThing mycocerosate synthase activity Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+). got7fsn_ti acyl-CoA:methylmalonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)|mycocerosic acid synthase activity EC:2.3.1.111|KEGG_REACTION:R05189|RHEA:10588|MetaCyc:MYCOCEROSATE-SYNTHASE-RXN molecular_function owl:Class
GO:0016250 biolink:NamedThing N-sulfoglucosamine sulfohydrolase activity Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate. got7fsn_ti N-sulphoglucosamine sulphohydrolase activity|2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)|sulphamidase activity|sulfoglucosamine sulfamidase activity|heparin sulfamidase activity|N-sulfo-D-glucosamine sulfohydrolase activity Reactome:R-HSA-2090043|EC:3.10.1.1|Reactome:R-HSA-1678708|Reactome:R-HSA-9036050|Reactome:R-HSA-2263444|MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN|RHEA:17881 molecular_function owl:Class
GO:0047621 biolink:NamedThing acylpyruvate hydrolase activity Catalysis of the reaction: a 3-acylpyruvate + H2O = a carboxylate + pyruvate. got7fsn_ti 3-acylpyruvate acylhydrolase activity MetaCyc:ACYLPYRUVATE-HYDROLASE-RXN|RHEA:19009|UM-BBD_reactionID:r1401|EC:3.7.1.5 molecular_function owl:Class
GO:0009239 biolink:NamedThing enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. got7fsn_ti enterobactin biosynthetic process, peptide modification|enterobactin biosynthetic process, peptide formation|enterobactin synthetase|enterobactin anabolism|enterochelin biosynthesis|enterobactin biosynthesis|enterochelin biosynthetic process|enterobactin formation|enterobactin synthesis GO:0031191|GO:0031192 MetaCyc:ENTBACSYN-PWY biological_process owl:Class
GO:0071443 biolink:NamedThing tDNA binding Binding to DNA sequences encoding transfer RNA. got7fsn_ti mah 2009-12-16T03:47:31Z molecular_function owl:Class
GO:0010855 biolink:NamedThing adenylate cyclase inhibitor activity Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate. got7fsn_ti molecular_function owl:Class
GO:0018740 biolink:NamedThing 2'-hydroxybiphenyl-2-sulfinate desulfinase activity Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite. got7fsn_ti HBPSi desulfinase activity|2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity|2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity|2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity|HPBS desulfinase activity|2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity|gene dszB-encoded hydrolase activity|2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity|DszB|2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity|2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity|2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity|dibenzothiophene desulfurization enzyme B UM-BBD_enzymeID:e0216|RHEA:12945|EC:3.13.1.3|MetaCyc:RXN-624|KEGG_REACTION:R07311 molecular_function owl:Class
GO:1990081 biolink:NamedThing trimethylamine receptor activity Combining with the biogenic amine trimethylamine to initiate a change in cell activity. got7fsn_ti sp 2013-04-30T10:57:07Z molecular_function owl:Class
GO:0061792 biolink:NamedThing secretory granule maturation Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodelling. got7fsn_ti dph 2016-09-09T13:24:34Z biological_process owl:Class
GO:0002289 biolink:NamedThing NK T cell proliferation involved in immune response The expansion of a NK T cell population by cell division as part of an immune response. got7fsn_ti NK T cell proliferation during immune response|natural killer T lymphocyte proliferation during immune response|NK T-cell proliferation during immune response|natural killer T-lymphocyte proliferation during immune response|natural killer T-cell proliferation during immune response|NK T-lymphocyte proliferation during immune response|NK T lymphocyte proliferation during immune response biological_process owl:Class
GO:0002288 biolink:NamedThing NK T cell activation involved in immune response The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. got7fsn_ti natural killer T-lymphocyte activation during immune response|natural killer T-cell activation during immune response|NK T-lymphocyte activation during immune response|NK T-cell activation during immune response|natural killer T lymphocyte activation during immune response|NK T lymphocyte activation during immune response|NK T cell activation during immune response biological_process owl:Class
GO:0102300 biolink:NamedThing linoleate 9R-lipoxygenase activity Catalysis of the reaction: linoleate + O2 = 9(R)-HPODE. got7fsn_ti RHEA:31691|MetaCyc:RXN-12760|EC:1.13.11.61 molecular_function owl:Class
GO:0004411 biolink:NamedThing homogentisate 1,2-dioxygenase activity Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). got7fsn_ti homogentisic acid oxidase activity|homogentisate dioxygenase activity|homogentisic oxygenase activity|homogentisate:oxygen 1,2-oxidoreductase (decyclizing)|homogentisate oxidase activity|homogentisate oxygenase activity|homogentisic acid oxygenase activity|homogentisicase activity RHEA:15449|UM-BBD_reactionID:r0105|MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN|Reactome:R-HSA-71164|EC:1.13.11.5|KEGG_REACTION:R02519 molecular_function owl:Class
GO:0047963 biolink:NamedThing glycine N-choloyltransferase activity Catalysis of the reaction: choloyl-CoA + glycine = CoA + glycocholate. got7fsn_ti cholyl-CoA:taurine N-acyltransferase activity|bile acid-CoA:amino acid N-acyltransferase activity|choloyl-CoA:glycine N-choloyltransferase activity|BACAT activity|glycine--taurine N-acyltransferase activity|cholyl-CoA glycine-taurine N-acyltransferase activity|amino acid N-choloyltransferase activity|BAT activity RHEA:14001|MetaCyc:GLYCINE-N-CHOLOYLTRANSFERASE-RXN|EC:2.3.1.65 molecular_function owl:Class
GO:0016045 biolink:NamedThing detection of bacterium The series of events in which a stimulus from a bacterium is received and converted into a molecular signal. got7fsn_ti perception of bacterium|detection of bacteria|perception of bacteria GO:0009598|GO:0009681 biological_process owl:Class
GO:0030978 biolink:NamedThing alpha-glucan metabolic process The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds. got7fsn_ti alpha-glucan metabolism biological_process owl:Class
GO:0001591 biolink:NamedThing dopamine neurotransmitter receptor activity, coupled via Gi/Go Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. got7fsn_ti dopamine D3 receptor activity|dopamine D4 receptor activity|dopamine D2 receptor activity GO:0001592|GO:0001670|GO:0001593 molecular_function owl:Class
GO:0018751 biolink:NamedThing 3,5-dichlorophenylcarboximide hydrolase activity Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate. got7fsn_ti UM-BBD_reactionID:r0707 molecular_function owl:Class
GO:0050750 biolink:NamedThing low-density lipoprotein particle receptor binding Binding to a low-density lipoprotein receptor. got7fsn_ti low-density lipoprotein receptor binding|LDL receptor binding molecular_function owl:Class
GO:0102346 biolink:NamedThing 3-hydroxy-cerotoyl-CoA dehydratase activity Catalysis of the reaction: (R)-3-hydroxycerotoyl-CoA(4-) <=> trans-2-hexacosenoyl-CoA(4-) + H2O. got7fsn_ti MetaCyc:RXN-13305 molecular_function owl:Class
GO:0120235 biolink:NamedThing regulation of posttranslational protein targeting to membrane, translocation Any process that modulates the frequency, rate or extent of posttranslational protein translocation through the ER membrane. got7fsn_ti regulation of N-terminal signal peptide-independent translocation into the ER|regulation of posttranslational endoplasmic reticulum membrane protein translocation|regulation of SRP-independent endoplasmic reticulum protein-membrane targeting, translocation https://github.com/geneontology/go-ontology/issues/19791 krc 2020-08-03T16:46:15Z biological_process owl:Class
GO:0046571 biolink:NamedThing aspartate-2-keto-4-methylthiobutyrate transaminase activity Catalysis of the reaction: 2-keto-4-methylthiobutyrate + aspartate = methionine + oxaloacetate. got7fsn_ti molecular_function owl:Class
GO:0019480 biolink:NamedThing L-alanine oxidation to pyruvate via D-alanine The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate. got7fsn_ti MetaCyc:ALADEG-PWY biological_process owl:Class
GO:0034781 biolink:NamedThing N-cyclohexylformamide amidohydrolase activity Catalysis of the reaction: N-cyclohexylformamide + OH- = cyclohexylamine + formate. got7fsn_ti UM-BBD_reactionID:r1030 molecular_function owl:Class
GO:0019682 biolink:NamedThing glyceraldehyde-3-phosphate metabolic process The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis. got7fsn_ti glyceraldehyde-3-phosphate metabolism|glyceraldehyde 3-phosphate metabolic process|glyceraldehyde 3-phosphate metabolism biological_process owl:Class
GO:1990506 biolink:NamedThing mitotic DNA-dependent DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle. got7fsn_ti al 2014-10-01T14:13:23Z biological_process owl:Class
GO:0072348 biolink:NamedThing sulfur compound transport The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti sulfur-containing compound transport mah 2010-11-11T11:43:56Z biological_process owl:Class
GO:0062245 biolink:NamedThing double membrane vesicle viral factory inner membrane The inner of the two endoplasmic reticulum-derived lipid bilayer membranes that bound a double membrane vesicle viral factory. got7fsn_ti inner membrane of double membrane vesicle viral factory dph 2020-04-20T20:55:49Z cellular_component owl:Class
GO:0140509 biolink:NamedThing epithelium-like organization The organization of a polarized cell layer during morphogenesis in protozoa; an example is found during culmination in D. discoideum, involving alpha and beta catenins. got7fsn_ti pg 2020-08-28T07:29:53Z biological_process owl:Class
GO:0009944 biolink:NamedThing polarity specification of adaxial/abaxial axis The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure. got7fsn_ti biological_process owl:Class
GO:0008609 biolink:NamedThing alkylglycerone-phosphate synthase activity Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion. got7fsn_ti alkyldihydroxyacetone phosphate synthetase activity|alkyl-DHAP|DHAP-AT|alkyl-DHAP synthase activity|dihydroxyacetone-phosphate acyltransferase activity|alkyldihydroxyacetonephosphate synthase activity|1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity|alkyl DHAP synthetase activity EC:2.5.1.26|Reactome:R-HSA-390427|RHEA:36171|MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN molecular_function owl:Class
GO:0046933 biolink:NamedThing proton-transporting ATP synthase activity, rotational mechanism Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out). got7fsn_ti hydrogen ion transporting ATP synthase activity, rotational mechanism|H+-transporting ATP synthase activity|hydrogen ion translocating F-type ATPase activity|hydrogen ion transporting two-sector ATPase activity https://github.com/geneontology/go-ontology/issues/19380 Reactome:R-HSA-164832|EC:7.1.2.2|MetaCyc:ATPSYN-RXN|TC:3.A.2.1.1|RHEA:57720 molecular_function owl:Class
GO:1990776 biolink:NamedThing response to angiotensin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen. got7fsn_ti sl 2015-06-16T17:41:17Z biological_process owl:Class
GO:0043698 biolink:NamedThing iridosome A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance. got7fsn_ti reflecting platelet cellular_component owl:Class
GO:0036182 biolink:NamedThing asperthecin metabolic process The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. got7fsn_ti asperthecin metabolism bf 2012-04-16T11:35:24Z biological_process owl:Class
GO:0102479 biolink:NamedThing quercetin 3-O-beta:-D-galactosyltransferase activity Catalysis of the reaction: quercetin-7-olate + UDP-D-galactose <=> quercetin 3-O-beta-D-galactopyranoside + UDP(3-) + H+. got7fsn_ti EC:2.4.1.234|MetaCyc:RXN-14109 molecular_function owl:Class
GO:0034973 biolink:NamedThing Sid2-Mob1 complex A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex. got7fsn_ti Sid2p-Mob1p complex|Dbf2p-Mob1p complex|Sid2-Mob1 kinase complex cellular_component owl:Class
GO:0047095 biolink:NamedThing 2-hydroxycyclohexanone 2-monooxygenase activity Catalysis of the reaction: 2-hydroxycyclohexan-1-one + NADPH + O(2) = 6-oxohexanoate + H(2)O + NADP(+). got7fsn_ti 2-hydroxycyclohexan-1-one,NADPH:oxygen 2-oxidoreductase (1,2-lactonizing) EC:1.14.13.66|KEGG_REACTION:R03281|RHEA:33283|MetaCyc:1.14.13.66-RXN molecular_function owl:Class
GO:0055052 biolink:NamedThing ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. got7fsn_ti cellular_component owl:Class
GO:0047851 biolink:NamedThing dicarboxylate-CoA ligase activity Catalysis of the reaction: ATP + an omega-dicarboxylic acid + CoASH= AMP + diphosphate + an omega-carboxyacyl-CoA. got7fsn_ti omega-dicarboxylate:CoA ligase (AMP-forming)|carboxylyl-CoA synthetase activity RHEA:14289|EC:6.2.1.23|MetaCyc:DICARBOXYLATE--COA-LIGASE-RXN molecular_function owl:Class
GO:0036245 biolink:NamedThing cellular response to menadione Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position. got7fsn_ti cellular response to vitamin K3 bf 2012-05-28T10:23:02Z biological_process owl:Class
GO:0001001 biolink:NamedThing mitochondrial single-subunit type RNA polymerase binding Binding to a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6. got7fsn_ti krc 2010-08-17T05:01:28Z molecular_function owl:Class
GO:0038161 biolink:NamedThing prolactin signaling pathway A series of molecular signals initiated by the binding of the peptide hormone prolactin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti prolactin-mediated signaling pathway|PRL signaling pathway bf 2012-05-14T01:52:59Z biological_process owl:Class
GO:0090375 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions. got7fsn_ti negative regulation of transcription from RNA polymerase II promoter in response to iron deficiency tb 2010-09-01T01:22:23Z biological_process owl:Class
GO:1990632 biolink:NamedThing branching involved in submandibular gland morphogenesis The process in which the branching structure of the submandibular gland is generated and organized. got7fsn_ti submandibular gland ductal branching|submandibular gland branching morphogenesis cls 2015-02-10T14:40:01Z biological_process owl:Class
GO:0060445 biolink:NamedThing branching involved in salivary gland morphogenesis The process in which the branching structure of the salivary gland is generated and organized. got7fsn_ti biological_process owl:Class
GO:0090519 biolink:NamedThing anoxia protection Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia. got7fsn_ti tb 2012-12-21T15:37:37Z biological_process owl:Class
GO:0045850 biolink:NamedThing positive regulation of nurse cell apoptotic process Any process that activates or increases the frequency, rate or extent of nurse cell apoptotic process. got7fsn_ti upregulation of nurse cell apoptosis|up-regulation of nurse cell apoptosis|stimulation of nurse cell apoptosis|up regulation of nurse cell apoptosis|activation of nurse cell apoptosis|positive regulation of nurse cell apoptosis biological_process owl:Class
GO:0018795 biolink:NamedThing 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate. got7fsn_ti UM-BBD_reactionID:r0621 molecular_function owl:Class
GO:0019180 biolink:NamedThing dTDP-4-amino-4,6-dideoxygalactose transaminase activity Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose. got7fsn_ti thymidine diphosphoaminodideoxygalactose aminotransferase activity|dTDP-fucosamine aminotransferase activity|thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity|dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity|dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity MetaCyc:2.6.1.59-RXN|KEGG_REACTION:R04438|RHEA:10368|EC:2.6.1.59 molecular_function owl:Class
GO:0102536 biolink:NamedThing sakuranetin 6-hydroxylase activity Catalysis of the reaction: sakuranetin + O2 + NADPH + H+ <=> carthamidin-7-methyl ether + H2O + NADP. got7fsn_ti MetaCyc:RXN-14754 molecular_function owl:Class
GO:0102680 biolink:NamedThing campest-4-en-3-one hydroxylase activity Catalysis of the reaction: H+ + campest-4-en-3-one + O2 + NADPH <=> (22S)-22-hydroxycampest-4-en-3-one + H2O + NADP. got7fsn_ti MetaCyc:RXN-4231 molecular_function owl:Class
GO:0047603 biolink:NamedThing acetoacetyl-CoA hydrolase activity Catalysis of the reaction: acetoacetyl-CoA + H(2)O = acetoacetate + CoA + H(+). got7fsn_ti acetoacetyl CoA deacylase activity|acetoacetyl coenzyme A deacylase activity|acetoacetyl coenzyme A hydrolase activity EC:3.1.2.11|RHEA:15673|KEGG_REACTION:R01358|MetaCyc:ACETOACETYL-COA-HYDROLASE-RXN molecular_function owl:Class
GO:0008851 biolink:NamedThing ethanolamine ammonia-lyase activity Catalysis of the reaction: ethanolamine = acetaldehyde + NH3. got7fsn_ti ethanolamine deaminase activity|ethanolamine ammonia-lyase (acetaldehyde-forming) activity RHEA:15313|MetaCyc:ETHAMLY-RXN|EC:4.3.1.7 molecular_function owl:Class
GO:0051072 biolink:NamedThing 4,6-pyruvylated galactose residue biosynthetic process The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain. got7fsn_ti 4,6-pyruvylated galactose residue formation|4,6-pyruvylated galactose residue biosynthesis|4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthesis|PvGal biosynthetic process|PvGal biosynthesis|4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 biosynthetic process|4,6-pyruvylated galactose residue synthesis|4,6-pyruvylated galactose residue anabolism biological_process owl:Class
GO:0102466 biolink:NamedThing beta-carotene 2,2'-beta-hydroxylase activity Catalysis of the reaction: beta-carotene + 2 NADH + 2 H+ + 2 O2 = (2R,2'R)-dihydroxy-all-trans-beta-carotene + 2 NAD + 2 H2O. got7fsn_ti MetaCyc:RXN-14019 molecular_function owl:Class
GO:0035403 biolink:NamedThing histone kinase activity (H3-T6 specific) Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3. got7fsn_ti histone threonine kinase activity (H3-T6 specific)|histone-threonine kinase activity (H3-T6 specific) bf 2010-03-24T10:05:39Z molecular_function owl:Class
GO:0071574 biolink:NamedThing protein localization to medial cortex A process in which a protein is transported to, or maintained in, the medial cortex. got7fsn_ti protein localisation to medial cortex mah 2010-01-26T05:17:50Z biological_process owl:Class
GO:0047624 biolink:NamedThing adenosine-tetraphosphatase activity Catalysis of the reaction: adenosine 5'-tetraphosphate + H2O = ATP + phosphate. got7fsn_ti adenosine-tetraphosphate phosphohydrolase activity EC:3.6.1.14|MetaCyc:ADENOSINE-TETRAPHOSPHATASE-RXN|RHEA:24500 molecular_function owl:Class
GO:0070082 biolink:NamedThing clathrin-sculpted monoamine transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted monoamine transport vesicle. got7fsn_ti clathrin sculpted monoamine transport vesicle lumen|clathrin sculpted monoamine constitutive secretory pathway transport vesicle lumen cellular_component owl:Class
GO:0042334 biolink:NamedThing taxis to electron acceptor The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate. got7fsn_ti taxis in response to electron acceptor biological_process owl:Class
GO:0036151 biolink:NamedThing phosphatidylcholine acyl-chain remodeling Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. got7fsn_ti bf 2012-03-14T01:54:13Z biological_process owl:Class
GO:0042540 biolink:NamedThing hemoglobin catabolic process The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids. got7fsn_ti hemoglobin hydrolysis|hemoglobin degradation|haemoglobin catabolic process|hemoglobin breakdown|hemoglobin catabolism|haemoglobin catabolism|haemoglobin hydrolysis Note that 'hydrolysis' is actually a reaction rather than a process. The synonym 'hemoglobin hydrolysis' was the text string associated with the secondary ID GO:0020029, which was retained because its definition did describe a process. GO:0020029 biological_process owl:Class
GO:0043877 biolink:NamedThing galactosamine-6-phosphate isomerase activity Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3. got7fsn_ti AgaI|galactosamine-6-phosphate deaminase activity This function is part of the pathway of N-acetyl-galactosamine and galactosamine utilization. molecular_function owl:Class
GO:0097183 biolink:NamedThing protein C inhibitor-coagulation factor XI complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI. got7fsn_ti protein C inhibitor-F11 complex|SERPINA5-coagulation factor XI complex|plasma serine protease inhibitor-coagulation factor XI complex|serpin A5-coagulation factor XI complex|PCI-coagulation factor XI complex pr 2011-10-16T09:03:22Z cellular_component owl:Class
GO:0097415 biolink:NamedThing cortical Lewy body Cytoplasmic inclusion similar to a classical Lewy body but lacking a halo of protein fibrils. got7fsn_ti pr 2012-11-06T16:29:11Z NIF_Subcellular:sao4040591221 cellular_component owl:Class
GO:0007172 biolink:NamedThing signal complex assembly The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. got7fsn_ti signal complex formation biological_process owl:Class
GO:0102312 biolink:NamedThing 4-coumaroyl 2'-hydroxylase activity Catalysis of the reaction: 4-coumaryl-CoA + 2-oxoglutarate + O2 <=> 2,4-dihydroxycinnamoyl-CoA + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-12963|EC:1.14.11.62|RHEA:57868 molecular_function owl:Class
GO:0034574 biolink:NamedThing didemethylisoproturon dehydrogenase activity Catalysis of the reaction: didemethylisoproturon + H2O = 4'-(2-hydroxyisopropyl)phenylurea + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0899|EC:1.17.99.- molecular_function owl:Class
GO:0034066 biolink:NamedThing Ric1-Rgp1 guanyl-nucleotide exchange factor complex A protein complex that acts as a nucleotide exchange factor for the GTPase Ypt6p, and is required for fusion of endosome-derived vesicles with the Golgi. got7fsn_ti Ric1p-Rgp1p complex cellular_component owl:Class
GO:0006433 biolink:NamedThing prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA. got7fsn_ti biological_process owl:Class
GO:0120210 biolink:NamedThing rod telodendria Rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina. got7fsn_ti krc 2019-05-21T00:34:22Z cellular_component owl:Class
GO:0018833 biolink:NamedThing DDT-dehydrochlorinase activity Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+). got7fsn_ti DDT-as|DDTase activity|1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity|1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]|DDT dehydrochlorinase activity|DDT-ase activity KEGG_REACTION:R04522|UM-BBD_reactionID:r0439|RHEA:19217|EC:4.5.1.1|MetaCyc:DDT-DEHYDROCHLORINASE-RXN molecular_function owl:Class
GO:0051659 biolink:NamedThing maintenance of mitochondrion location Any process in which a mitochondrion is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of mitochondria localization|maintenance of mitochondrion localization biological_process owl:Class
GO:0033476 biolink:NamedThing indoleacetic acid ester conjugate biosynthetic process The chemical reactions and pathways resulting in the formation of an indole-3-acetic acid amide conjugate, a form of indoleacetic acid covalently bound to an a sugar or polyol through an ester bond. got7fsn_ti indoleacetic acid ester conjugate synthesis|indoleacetic acid ester conjugate formation|indoleacetic acid ester conjugate biosynthesis|indoleacetic acid ester conjugate anabolism|indole acetic acid ester conjugate biosynthetic process|indole acetic acid ester conjugate biosynthesis|IAA ester conjugate biosynthetic process MetaCyc:PWY-1741 biological_process owl:Class
GO:0009042 biolink:NamedThing valine-pyruvate transaminase activity Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine. got7fsn_ti alanine--valine transaminase activity|valine-pyruvate aminotransferase activity|L-valine:pyruvate aminotransferase activity|transaminase C activity|alanine-oxoisovalerate aminotransferase activity|valine--pyruvate aminotransferase activity MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN|EC:2.6.1.66|RHEA:22912|KEGG_REACTION:R01215 molecular_function owl:Class
GO:0015182 biolink:NamedThing L-asparagine transmembrane transporter activity Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid. got7fsn_ti asparagine/glutamine permease activity|L-asparagine transporter activity molecular_function owl:Class
GO:0051764 biolink:NamedThing actin crosslink formation The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes. got7fsn_ti actin bundling|formation of actin crosslink|bridging actin filaments|actin crosslinking See also the molecular function term 'protein binding, bridging ; GO:0030674'. biological_process owl:Class
GO:0034972 biolink:NamedThing histone H3-R26 methylation The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone. got7fsn_ti histone lysine H3 R26 methylation|histone H3 R26 methylation|histone H3R26me biological_process owl:Class
GO:0008061 biolink:NamedThing chitin binding Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. got7fsn_ti molecular_function owl:Class
GO:0016327 biolink:NamedThing apicolateral plasma membrane The apical end of the lateral plasma membrane of epithelial cells. got7fsn_ti apical lateral plasma membrane cellular_component owl:Class
GO:0005609 biolink:NamedThing laminin-4 complex A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains. got7fsn_ti laminin-221 complex cellular_component owl:Class
GO:0052067 biolink:NamedThing antiphagocytosis Any process in which a symbiont avoids phagocytosis by a host cell, for example a phagocyte or a macrophage. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti downregulation by symbiont of entry into host cell via phagocytosis|negative regulation by organism of entry into cell of other organism via phagocytosis involved in symbiotic interaction|modulation by organism of entry into host via host phagocytosis|modulation by symbiont of entry into host via phagocytosis|negative regulation by organism of entry into host cell via host phagocytosis|down regulation by symbiont of entry into host cell via phagocytosis|negative regulation by symbiont of entry into host cell via phagocytosis|phagocytosis avoidence|inhibition by symbiont of entry into host cell via phagocytosis|down-regulation by symbiont of entry into host cell via phagocytosis https://github.com/geneontology/go-ontology/issues/17983|https://github.com/geneontology/go-ontology/issues/18562 GO:0052483|GO:0052380 biological_process owl:Class
GO:0047209 biolink:NamedThing coniferyl-alcohol glucosyltransferase activity Catalysis of the reaction: coniferyl alcohol + UDP-D-glucose = coniferin + UDP. got7fsn_ti UDP-glucose coniferyl alcohol glucosyltransferase activity|UDP-glucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity|UDPglucose:coniferyl-alcohol 4'-beta-D-glucosyltransferase activity|uridine diphosphoglucose-coniferyl alcohol glucosyltransferase activity MetaCyc:2.4.1.111-RXN|RHEA:23944|EC:2.4.1.111 molecular_function owl:Class
GO:0004846 biolink:NamedThing urate oxidase activity Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide. got7fsn_ti urate:oxygen oxidoreductase activity|uricase activity|uric acid oxidase activity|uricase II activity MetaCyc:URATE-OXIDASE-RXN|RHEA:21368|EC:1.7.3.3|UM-BBD_reactionID:r1322 molecular_function owl:Class
GO:0034537 biolink:NamedThing 2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity Catalysis of the reaction: 2-hydroxy-3-methylbenzalpyruvate + H2O = pyruvate + 3-methylsalicylaldehyde. got7fsn_ti UM-BBD_reactionID:r0783 molecular_function owl:Class
GO:1990380 biolink:NamedThing Lys48-specific deubiquitinase activity Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein. got7fsn_ti K48-specific deubiquitinating activity|K48-specific deubiquitinase activity bf 2014-05-15T14:31:07Z Reactome:R-HSA-5690870 molecular_function owl:Class
GO:0050781 biolink:NamedThing ortho-trichlorophenol reductive dehalogenase activity Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl. got7fsn_ti 2,4,6-TCP reductive dehalogenase activity|2,4,6-trichlorophenol reductive dehalogenase activity molecular_function owl:Class
GO:0050981 biolink:NamedThing detection of electrical stimulus The series of events by which an electrical stimulus is received and converted into a molecular signal. got7fsn_ti biological_process owl:Class
GO:0102427 biolink:NamedThing allocryptopine 6-hydroxylase activity Catalysis of the reaction: allocryptopine + NADPH + O2 + H+ <=> 6-hydroxy-allocryptopine + NADP + H2O. got7fsn_ti MetaCyc:RXN-13828 molecular_function owl:Class
GO:0018191 biolink:NamedThing peptidyl-serine octanoylation The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin. got7fsn_ti RESID:AA0290 biological_process owl:Class
GO:0060072 biolink:NamedThing large conductance calcium-activated potassium channel activity Enables the transmembrane transfer of potassium by a channel with a unit conductance of 100 to 220 picoSiemens that opens in response to stimulus by concerted actions of internal calcium ions and membrane potential. Large conductance calcium-activated potassium channels are less sensitive to calcium than are small or intermediate conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. got7fsn_ti large conductance KCa channel activity|BK channel activity|BK calcium-activated potassium channel activity|BK KCa channel activity GO:0022895 molecular_function owl:Class
GO:0043981 biolink:NamedThing histone H4-K5 acetylation The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone. got7fsn_ti histone H4 acetylation at K5 biological_process owl:Class
GO:0047180 biolink:NamedThing salutaridinol 7-O-acetyltransferase activity Catalysis of the reaction: (7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA. got7fsn_ti acetyl-CoA:salutaridinol 7-O-acetyltransferase activity RHEA:22856|MetaCyc:2.3.1.150-RXN|KEGG_REACTION:R04723|EC:2.3.1.150 molecular_function owl:Class
GO:0016272 biolink:NamedThing prefoldin complex A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics. got7fsn_ti GIM complex Wikipedia:Prefoldin cellular_component owl:Class
GO:0062210 biolink:NamedThing shoot regeneration The regeneration process by which a damaged or lost shoot regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to produce a new shoot meristem and subsequently a new shoot. got7fsn_ti shoot system regeneration dph 2020-02-21T12:38:43Z biological_process owl:Class
GO:0034670 biolink:NamedThing chemotaxis to arachidonic acid The directed movement of a motile cell or organism in response to the presence of arachidonic acid. got7fsn_ti biological_process owl:Class
GO:0140684 biolink:NamedThing histone H3-tri/dimethyl-lysine-9 demethylase activity Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone H3K9me2 demethylase activity|histone H3K9me3 demethylase activity https://github.com/geneontology/go-ontology/issues/21089 pg 2021-07-09T06:03:55Z RHEA:60200|EC:1.14.11.66 molecular_function owl:Class
GO:0004035 biolink:NamedThing alkaline phosphatase activity Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. got7fsn_ti orthophosphoric-monoester phosphohydrolase (alkaline optimum)|phosphomonoesterase activity|alkaline phenyl phosphatase activity|phosphate-monoester phosphohydrolase (alkaline optimum)|alkaline phosphomonoesterase activity|glycerophosphatase activity|alkaline phosphohydrolase activity EC:3.1.3.1|MetaCyc:ALKAPHOSPHA-RXN|Reactome:R-HSA-8878787 molecular_function owl:Class
GO:0050888 biolink:NamedThing determination of stimulus location The determination of where on the body surface, within the body or in the environment a stimulus originates. got7fsn_ti biological_process owl:Class
GO:0072591 biolink:NamedThing citrate-L-glutamate ligase activity Catalysis of the reaction: ATP + citrate + L-glutamate = ADP + phosphate + beta-citryl-L-glutamate. got7fsn_ti mah 2011-02-10T03:24:26Z molecular_function owl:Class
GO:0032607 biolink:NamedThing interferon-alpha production The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interferon-alpha secretion|interferon-alpha biosynthetic process|IFNA production|IFN-alpha production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072642|GO:0045349 biological_process owl:Class
GO:0140548 biolink:NamedThing envenomation resulting in blood agglutination in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with specific proteins binding to cell-surface carbohydrates and causing calcium-dependent agglutination of blood cells in the bitten organism. got7fsn_ti envenomation resulting in erythrocytes agglutination in other organism|envenomation resulting in red blood cells agglutination in other organism https://github.com/geneontology/go-ontology/issues/18979 pg 2020-11-11T21:42:31Z biological_process owl:Class
GO:0030976 biolink:NamedThing thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. got7fsn_ti thiamin pyrophosphate binding|diphosphothiamin binding|aneurine pyrophosphate binding|TPP binding|cocarboxylase binding molecular_function owl:Class
GO:0016785 biolink:NamedThing selenotransferase activity Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor). got7fsn_ti transferase activity, transferring selenium-containing groups https://github.com/geneontology/go-ontology/issues/20486 GO:0016786 EC:2.9.1.- molecular_function owl:Class
GO:0039512 biolink:NamedThing suppression by virus of host protein tyrosine kinase activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity. got7fsn_ti downregulation by virus of host protein tyrosine kinase activity|down-regulation by virus of host protein tyrosine kinase activity|inhibition by virus of host protein tyrosine kinase activity|negative regulation by virus of host protein tyrosine kinase activity bf 2011-06-16T02:27:26Z biological_process owl:Class
GO:0032164 biolink:NamedThing hyphal septin cap A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol. got7fsn_ti cellular_component owl:Class
GO:0044017 biolink:NamedThing histone acetyltransferase activity (H3-K27 specific) Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27). got7fsn_ti histone lysine N-acetyltransferase activity (H3-K27 specific) molecular_function owl:Class
GO:0019397 biolink:NamedThing gallate catabolic process via 2-pyrone-4,6-dicarboxylate The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate. got7fsn_ti gallic acid catabolism via 2-pyrone-4,6-dicarboxylate|gallate breakdown via 2-pyrone-4,6-dicarboxylate|gallate degradation via 2-pyrone-4,6-dicarboxylate|gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate MetaCyc:GALLATE-DEGRADATION-I-PWY biological_process owl:Class
GO:0018235 biolink:NamedThing peptidyl-lysine carboxylation The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine. got7fsn_ti RESID:AA0114 biological_process owl:Class
GO:0030266 biolink:NamedThing quinate 3-dehydrogenase (NAD+) activity Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+. got7fsn_ti quinate:NAD 3-oxidoreductase activity|quinate:NAD(+) 3-oxidoreductase activity|quinate:NAD(+) 5-oxidoreductase activity|quinate:NAD 5-oxidoreductase activity|quinic dehydrogenase activity KEGG_REACTION:R01872|EC:1.1.1.24|MetaCyc:QUINATE-5-DEHYDROGENASE-RXN|RHEA:22364|EC:1.1.1.282 molecular_function owl:Class
GO:0034158 biolink:NamedThing toll-like receptor 8 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 8. got7fsn_ti TLR8 signaling pathway|toll-like receptor 8 signalling pathway biological_process owl:Class
GO:0035584 biolink:NamedThing calcium-mediated signaling using intracellular calcium source A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response. got7fsn_ti calcium-mediated signalling using intracellular calcium source|calcium signaling using intracellular calcium source|calcium signalling using intracellular calcium source bf 2010-10-18T11:01:08Z biological_process owl:Class
GO:0033560 biolink:NamedThing folate reductase activity Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+. got7fsn_ti Reactome:R-HSA-197963|RHEA:31103|Reactome:R-HSA-197972 molecular_function owl:Class
GO:0002534 biolink:NamedThing cytokine production involved in inflammatory response The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti cytokine production involved in acute inflammatory response biological_process owl:Class
GO:0047663 biolink:NamedThing aminoglycoside 6'-N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + kanamycin B = N(6')-acetylkanamycin B + CoA + H(+). This is acetylation of the 6'-amino group of the 6-deoxy-6-aminoglucose ring. got7fsn_ti AAC(6') activity|6'-aminoglycoside-N-acetyltransferase activity|aminoglycoside-6'-acetyltransferase activity|kanamycin 6'-N-acetyltransferase activity|acetyl-CoA:kanamycin-B N6'-acetyltransferase activity|aminoglycoside N6'-acetyltransferase activity|aminoglycoside-6-N-acetyltransferase activity KEGG_REACTION:R01889|RHEA:16449|MetaCyc:AMINOGLYCOSIDE-N6-ACETYLTRANSFERASE-RXN|EC:2.3.1.82 molecular_function owl:Class
GO:0035616 biolink:NamedThing histone H2B conserved C-terminal lysine deubiquitination A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals. got7fsn_ti fission yeast H2B K119 deubiquitination|mammalian H2B K120 deubiquitination|budding yeast H2B K123 deubiquitination bf 2010-12-03T10:36:44Z biological_process owl:Class
GO:0044546 biolink:NamedThing NLRP3 inflammasome complex assembly The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell. got7fsn_ti NLRP3 inflammasome activation|NALP3 inflammasome complex assembly https://github.com/geneontology/go-ontology/issues/21092 jl 2012-03-22T01:27:21Z biological_process owl:Class
GO:0030411 biolink:NamedThing scytalone dehydratase activity Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O. got7fsn_ti scytalone 7,8-hydro-lyase activity|scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming) KEGG_REACTION:R02907|MetaCyc:SCYTALONE-DEHYDRATASE-RXN|EC:4.2.1.94|RHEA:24396 molecular_function owl:Class
GO:0044548 biolink:NamedThing S100 protein binding Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. got7fsn_ti S100 binding|S100 beta binding|S100 alpha binding jl 2012-03-22T03:23:51Z GO:0048155|GO:0048154 molecular_function owl:Class
GO:0072593 biolink:NamedThing reactive oxygen species metabolic process The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. got7fsn_ti reactive oxygen species metabolism|ROS metabolic process mah 2011-02-11T10:50:06Z biological_process owl:Class
GO:0050225 biolink:NamedThing pseudouridine kinase activity Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H(+) + pseudouridine 5'-phosphate. got7fsn_ti ATP:pseudouridine 5'-phosphotransferase activity|pseudouridine kinase (phosphorylating) MetaCyc:PSEUDOURIDINE-KINASE-RXN|KEGG_REACTION:R03315|EC:2.7.1.83|RHEA:22448 molecular_function owl:Class
GO:1990471 biolink:NamedThing piRNA uni-strand cluster binding Binding to uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa. got7fsn_ti bhm 2014-08-29T14:37:35Z molecular_function owl:Class
GO:0051767 biolink:NamedThing nitric-oxide synthase biosynthetic process The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. got7fsn_ti NOS biosynthesis|nitric-oxide synthase 2 biosynthetic process|NOS1 biosynthesis|NO synthase biosynthesis|NOS2 synthase biosynthesis|nitric-oxide synthase-3 biosynthetic process|NO synthase biosynthetic process|NOS2 biosynthesis|NOS3 biosynthesis|NOS2 synthase biosynthetic process|nitric-oxide synthase-2 biosynthetic process|NOS biosynthetic process|nitric-oxide synthase (type 2) biosynthesis|nitric-oxide synthase-1 biosynthetic process|endothelial nitric-oxide synthase biosynthetic process|nitric-oxide synthase (type II) biosynthetic process|nitric-oxide synthase (type 2) biosynthetic process|inducible nitric-oxide synthase biosynthetic process|nitric-oxide synthase (type II) biosynthesis|brain nitric-oxide synthase biosynthetic process GO:0051768 biological_process owl:Class
GO:0050074 biolink:NamedThing malate-CoA ligase activity Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA. got7fsn_ti malate:CoA ligase (ADP-forming)|malyl-CoA synthetase activity|malyl coenzyme A synthetase activity|malate thiokinase activity EC:6.2.1.9|MetaCyc:MALATE--COA-LIGASE-RXN|RHEA:26193 molecular_function owl:Class
GO:0010246 biolink:NamedThing rhamnogalacturonan I biosynthetic process The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide. got7fsn_ti rhamnogalacturonan I synthesis|rhamnogalacturonan I biosynthesis|rhamnogalacturonan I anabolism|rhamnogalacturonan I formation biological_process owl:Class
GO:0001966 biolink:NamedThing thigmotaxis The directed movement of a motile cell or organism in response to touch. got7fsn_ti stereotaxis|taxis in response to touch stimulus|taxis in response to mechanical stimulus biological_process owl:Class
GO:0102740 biolink:NamedThing theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity Catalysis of the reaction: theobromine + S-adenosyl-L-methionine <=> H+ + caffeine + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-7599|EC:2.1.1.160|RHEA:20944 molecular_function owl:Class
GO:0031481 biolink:NamedThing myosin XI complex A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions. got7fsn_ti cellular_component owl:Class
GO:0010384 biolink:NamedThing cell wall proteoglycan metabolic process The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates. got7fsn_ti cell wall proteoglycan metabolism biological_process owl:Class
GO:0099505 biolink:NamedThing regulation of presynaptic membrane potential Any process that modulates the potential difference across a presynaptic membrane. got7fsn_ti regulation of pre-synaptic membrane potential biological_process owl:Class
GO:0048203 biolink:NamedThing vesicle targeting, trans-Golgi to endosome The process in which vesicles are directed to specific destination membranes during transport from the trans-Golgi to the endosome. got7fsn_ti trans-Golgi to endosome targeting biological_process owl:Class
GO:0031476 biolink:NamedThing myosin VI complex A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments. got7fsn_ti cellular_component owl:Class
GO:0060112 biolink:NamedThing generation of ovulation cycle rhythm The process which controls the timing of the type of sexual cycle seen in female mammals. got7fsn_ti generation of menstrual cycle rhythm|generation of oestrus cycle rhythm|generation of estrus cycle rhythm biological_process owl:Class
GO:0060982 biolink:NamedThing coronary artery morphogenesis The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle. got7fsn_ti dph 2009-10-06T02:58:52Z biological_process owl:Class
GO:0071057 biolink:NamedThing alphav-beta3 integrin-ADAM15 complex A protein complex that consists of an alphav-beta3 integrin complex bound to the transmembrane metallopeptidase ADAM15. got7fsn_ti ITGAV-ITGB3-ADAM15 complex mah 2009-11-03T04:00:14Z cellular_component owl:Class
GO:0010066 biolink:NamedThing ground meristem histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues. got7fsn_ti biological_process owl:Class
GO:0018551 biolink:NamedThing hydrogensulfite reductase activity Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor. got7fsn_ti dissimilatory-type sulfite reductase activity|dissimilatory sulfite reductase activity|hydrogensulphite reductase activity|bisulfite reductase activity|desulfoviridin activity|desulfofuscidin activity|trithionate:acceptor oxidoreductase activity|trithionate:(acceptor) oxidoreductase activity|desulforubidin activity MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN|RHEA:13209|UM-BBD_reactionID:r0627|EC:1.8.99.3 molecular_function owl:Class
GO:0050379 biolink:NamedThing UDP-glucuronate 5'-epimerase activity Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-L-iduronate. got7fsn_ti UDP-glucuronic acid epimerase activity|UDPglucuronate 5'-epimerase activity|UDP-glucuronate 5' epimerase activity|uridine diphosphoglucuronate 5'-epimerase activity|C-5-uronosyl epimerase activity|UDP-glucuronic acid 5'-epimerase activity KEGG_REACTION:R01387|Reactome:R-HSA-2024100|Reactome:R-HSA-2076371|MetaCyc:UDP-GLUCURONATE-5-EPIMERASE-RXN molecular_function owl:Class
GO:0070386 biolink:NamedThing procollagen-proline 4-dioxygenase complex, alpha(I) type A procollagen-proline 4-dioxygenase complex that contains alpha subunits of the type I isoform; its activity is readily inhibited by poly(L-proline). got7fsn_ti prolyl 4-hydroxylase complex (alpha(I)-type)|procollagen-proline, 2-oxoglutarate-4-dioxygenase complex, alpha(I) type cellular_component owl:Class
GO:0093002 biolink:NamedThing response to nematicide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes. got7fsn_ti response to antihelmintic|response to nematocide biological_process owl:Class
GO:0099122 biolink:NamedThing RNA polymerase II C-terminal domain binding Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function. got7fsn_ti RNAP II C-terminal binding molecular_function owl:Class
GO:0080074 biolink:NamedThing spermidine:caffeoyl CoA N-acyltransferase activity Catalysis of the transfer of a caffeoyl group to a nitrogen atom on the spermidine molecule. got7fsn_ti dhl 2009-04-13T04:17:23Z molecular_function owl:Class
GO:0051959 biolink:NamedThing dynein light intermediate chain binding Binding to a light intermediate chain of the dynein complex. got7fsn_ti molecular_function owl:Class
GO:0039586 biolink:NamedThing modulation by virus of host PP1 activity The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response. got7fsn_ti modulation of host PP1 activity by virus|regulation by virus of host PP1 activity bf 2012-05-04T02:11:05Z VZ:803 biological_process owl:Class
GO:0039517 biolink:NamedThing modulation by virus of host protein serine/threonine phosphatase activity The process in which a virus effects a change in host protein serine/threonine phosphatase activity. got7fsn_ti modulation by virus of protein serine/threonine phosphatase activity in host|regulation by virus of host protein serine/threonine phosphatase activity bf 2011-06-16T03:04:14Z biological_process owl:Class
GO:0033784 biolink:NamedThing senecionine N-oxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + senecionine = H(2)O + NADP(+) + senecionine N-oxide. got7fsn_ti senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming) activity|SNO|senecionine monooxygenase (N-oxide-forming) activity EC:1.14.13.101|RHEA:11420|KEGG_REACTION:R07373|MetaCyc:1.14.13.101-RXN molecular_function owl:Class
GO:1901363 biolink:NamedThing heterocyclic compound binding Binding to heterocyclic compound. got7fsn_ti bf 2012-09-14T13:53:50Z molecular_function owl:Class
GO:0015350 biolink:NamedThing methotrexate transmembrane transporter activity Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. got7fsn_ti methotrexate transporter activity molecular_function owl:Class
GO:0030899 biolink:NamedThing calcium-dependent ATPase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+). got7fsn_ti molecular_function owl:Class
GO:0033836 biolink:NamedThing flavonol 7-O-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 7-O-beta-D-glucoside. got7fsn_ti UDP-glucose:flavonol 7-O-glucosyltransferase activity|UDP-glucose:flavonol 7-O-beta-D-glucosyltransferase activity MetaCyc:2.4.1.237-RXN|RHEA:23164|EC:2.4.1.237 molecular_function owl:Class
GO:0043665 biolink:NamedThing host peribacteroid fluid The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell. got7fsn_ti cellular_component owl:Class
GO:0050389 biolink:NamedThing uronolactonase activity Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate. got7fsn_ti D-glucurono-6,2-lactone lactonohydrolase activity|glucuronolactonase activity MetaCyc:URONOLACTONASE-RXN|EC:3.1.1.19|RHEA:13337 molecular_function owl:Class
GO:0019367 biolink:NamedThing fatty acid elongation, saturated fatty acid Elongation of a saturated fatty acid chain. got7fsn_ti MetaCyc:FASYN-ELONG-PWY biological_process owl:Class
GO:0044838 biolink:NamedThing cell quiescence A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed. got7fsn_ti cellular quiescence|cell cycle quiescence|G0 phase|quiescence Note that terminally differentiated cells in higher eukaryotes are typically quiescent but metabolically active. Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). Also, note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). jl 2014-02-26T16:15:51Z biological_process owl:Class
GO:0018252 biolink:NamedThing peptide cross-linking via L-seryl-5-imidazolinone glycine The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. got7fsn_ti biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine|biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. RESID:AA0184 biological_process owl:Class
GO:0043183 biolink:NamedThing vascular endothelial growth factor receptor 1 binding Binding to a vascular endothelial growth factor receptor 1. got7fsn_ti VEGFR 1 binding|VEGF receptor 1 binding|Flt-1 binding molecular_function owl:Class
GO:0001049 biolink:NamedThing RNA polymerase V core binding Binding to RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing. got7fsn_ti krc 2010-09-23T01:41:08Z molecular_function owl:Class
GO:0005728 biolink:NamedThing extrachromosomal rDNA circle Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats. got7fsn_ti extrachromosomal ribosomal DNA circle cellular_component owl:Class
GO:0034673 biolink:NamedThing inhibin-betaglycan-ActRII complex A protein complex that consists of inhibin, type III transforming growth factor beta receptor (also known as betaglycan), and the type II activin receptor ActRII. The complex is thought to negatively regulate the activity of activin B. got7fsn_ti cellular_component owl:Class
GO:0018746 biolink:NamedThing phenanthrene-3,4-epoxide hydrolase activity Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene. got7fsn_ti UM-BBD_reactionID:r0535 molecular_function owl:Class
GO:0106007 biolink:NamedThing microtubule anchoring at cell cortex of cell tip Any process in which a microtubule is maintained in a specific location at the cell tip by attachment to the cell cortex. got7fsn_ti hjd 2017-04-19T15:12:45Z biological_process owl:Class
GO:0102380 biolink:NamedThing steviolbioside glucosyltransferase activity (rebaudioside B forming) Catalysis of the reaction: steviolbioside + UDP-alpha-D-glucose = rebaudioside B + UDP + H+. got7fsn_ti MetaCyc:RXN-13516 molecular_function owl:Class
GO:0102259 biolink:NamedThing 1,2-diacylglycerol acylhydrolase activity Catalysis of the reaction: H2O + a 1,2-diacyl-sn-glycerol = a monoglyceride + a fatty acid. got7fsn_ti MetaCyc:RXN-12434 molecular_function owl:Class
GO:0097687 biolink:NamedThing dinoflagellate antapical horn A horn-shaped dinoflagellate antapex found in thecate species. got7fsn_ti pr 2014-12-18T09:39:57Z cellular_component owl:Class
GO:0008861 biolink:NamedThing formate C-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate. got7fsn_ti pyruvic formate-lyase activity|PFL|formate acetyltransferase activity|acetyl-CoA:formate C-acetyltransferase activity|pyruvate formate:lyase activity|pyruvate formate-lyase activity RHEA:11844|EC:2.3.1.54|MetaCyc:PYRUVFORMLY-RXN molecular_function owl:Class
GO:1990075 biolink:NamedThing periciliary membrane compartment A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis. got7fsn_ti PCMC pr 2013-04-24T10:14:50Z cellular_component owl:Class
GO:0010331 biolink:NamedThing gibberellin binding Binding to a gibberellin, a plant hormone that regulates aspects of plant growth. got7fsn_ti gibberellin receptor|gibberellic acid receptor molecular_function owl:Class
GO:0032527 biolink:NamedThing protein exit from endoplasmic reticulum The directed movement of proteins from the endoplasmic reticulum. got7fsn_ti protein exit from ER|protein export from endoplasmic reticulum|protein export from ER biological_process owl:Class
GO:0047517 biolink:NamedThing 1,4-beta-D-xylan synthase activity Catalysis of the reaction: UDP-D-xylose + [(1->4)-beta-D-xylan](n) = UDP + [(1->4)-beta-D-xylan](n+1). got7fsn_ti xylan synthase activity|xylan synthetase activity|UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase activity|1,4-beta-xylan synthase activity|uridine diphosphoxylose-1,4-beta-xylan xylosyltransferase activity RHEA:15289|EC:2.4.2.24|MetaCyc:RXN-9104 molecular_function owl:Class
GO:0016544 biolink:NamedThing male courtship behavior, tapping to detect pheromone The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster. got7fsn_ti male courtship behaviour, tapping to detect pheromone|male courtship behavior, tapping|male courtship behaviour, tapping biological_process owl:Class
GO:0090459 biolink:NamedThing aspartate homeostasis Any process involved in the maintenance of an internal steady state of aspartate within an organism or cell. got7fsn_ti tb 2012-09-24T14:22:02Z biological_process owl:Class
GO:0036486 biolink:NamedThing ventral trunk neural crest cell migration The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta. got7fsn_ti ventral trunk NCC migration|trunk NCC migration within somite|trunk NCC migration through anterior sclerotome bf 2014-08-26T15:30:16Z biological_process owl:Class
GO:0030679 biolink:NamedThing cyanelle ribonuclease P complex A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. got7fsn_ti cyanelle RNase P complex cellular_component owl:Class
GO:0034912 biolink:NamedThing phthalate 3,4-cis-dihydrodiol dehydrogenase activity Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+. got7fsn_ti MetaCyc:RXN5F9-56|UM-BBD_reactionID:r1445 molecular_function owl:Class
GO:1900205 biolink:NamedThing apoptotic process involved in metanephric nephron tubule development Any apoptotic process that is involved in metanephric nephron tubule development. got7fsn_ti programmed cell death by apoptosis of metanephric nephron tubule development|apoptotic programmed cell death of metanephric nephron tubule development|signaling (initiator) caspase activity of metanephric nephron tubule development|type I programmed cell death of metanephric nephron tubule development|apoptotic program of metanephric nephron tubule development|apoptotic cell death of metanephric nephron tubule development|apoptotic process of metanephric nephron tubule development|apoptosis of metanephric nephron tubule development yaf 2012-03-21T01:21:45Z biological_process owl:Class
GO:0052620 biolink:NamedThing thymine dehydrogenase activity Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2. got7fsn_ti RHEA:13469|MetaCyc:RXN-8646|EC:1.17.99.4 molecular_function owl:Class
GO:0050114 biolink:NamedThing myo-inosose-2 dehydratase activity Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O. got7fsn_ti 2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase activity|2,4,6/3,5-pentahydroxycyclohexanone hydro-lyase (3,5/4-trihydroxycyclohexa-1,2-dione-forming)|inosose 2,3-dehydratase activity|ketoinositol dehydratase activity RHEA:14065|EC:4.2.1.44|MetaCyc:MYO-INOSOSE-2-DEHYDRATASE-RXN|KEGG_REACTION:R02782 molecular_function owl:Class
GO:0004324 biolink:NamedThing ferredoxin-NADP+ reductase activity Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+. got7fsn_ti ferredoxin-TPN reductase activity|ferredoxin-NADP oxidoreductase activity|ferredoxin-NADP reductase activity|ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity|ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity|reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity|TPNH-ferredoxin reductase activity|ferredoxin:NADP+ oxidoreductase activity|NADPH:ferredoxin oxidoreductase activity|ferredoxin-NADP-oxidoreductase activity|NADP:ferredoxin oxidoreductase activity Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'. RHEA:20125|EC:1.18.1.2|MetaCyc:1.18.1.2-RXN molecular_function owl:Class
GO:0052763 biolink:NamedThing ulvan lyase activity Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end. got7fsn_ti ai 2011-09-29T03:39:23Z molecular_function owl:Class
GO:0070355 biolink:NamedThing synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Rab3a-complexin II complex A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, Rab3a, and complexin II (or orthologs thereof). got7fsn_ti STX1a-STX1b-SNAP25-RAB3a-SYT1-VAMP2-CPLX2 complex|SNARE complex (STX1a, STX1b, SNAP25, RAB3a, SYT1, VAMP2, CPLX2) cellular_component owl:Class
GO:0072565 biolink:NamedThing endothelial microparticle formation The cellular component organization process in which microparticles bud off from an endothelial cell. got7fsn_ti endothelial microparticle generation|endothelial microparticle release mah 2011-01-28T02:21:58Z biological_process owl:Class
GO:0061912 biolink:NamedThing selective autophagy The macroautophagy process in which specific structures are targeted by the autophagy process. got7fsn_ti dph 2017-07-07T17:27:37Z biological_process owl:Class
GO:0060747 biolink:NamedThing oral incubation A parental behavior in which fertilized eggs are taken into the mouth and held until hatching. got7fsn_ti dph 2009-06-22T09:08:58Z biological_process owl:Class
GO:0030373 biolink:NamedThing high molecular weight B cell growth factor receptor activity Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity. got7fsn_ti high molecular weight B-lymphocyte growth factor receptor activity|high molecular weight B-cell growth factor receptor activity|HMW-BCGF receptor|high molecular weight B lymphocyte growth factor receptor activity molecular_function owl:Class
GO:0071193 biolink:NamedThing Kv4.2-KChIP2 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2. got7fsn_ti mah 2009-11-23T04:58:09Z CORUM:607 cellular_component owl:Class
GO:0090009 biolink:NamedThing primitive streak formation The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis. got7fsn_ti tb 2009-07-29T10:31:31Z biological_process owl:Class
GO:2000943 biolink:NamedThing negative regulation of amylopectin metabolic process Any process that stops, prevents or reduces the frequency, rate or extent of amylopectin metabolic process. got7fsn_ti negative regulation of Amylopectin metabolism tt 2011-08-01T02:10:32Z biological_process owl:Class
GO:0031624 biolink:NamedThing ubiquitin conjugating enzyme binding Binding to a ubiquitin conjugating enzyme, any of the E2 proteins. got7fsn_ti molecular_function owl:Class
GO:0004774 biolink:NamedThing succinate-CoA ligase activity Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA. got7fsn_ti molecular_function owl:Class
GO:0010483 biolink:NamedThing pollen tube reception Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells. got7fsn_ti biological_process owl:Class
GO:0102571 biolink:NamedThing [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity Catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine). got7fsn_ti MetaCyc:RXN-15215|EC:3.2.1.169 molecular_function owl:Class
GO:0004142 biolink:NamedThing diacylglycerol cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine. got7fsn_ti phosphocholine diacylglyceroltransferase activity|alkylacylglycerol cholinephosphotransferase activity|alkylacylglycerol choline phosphotransferase activity|1-alkyl-2-acetylglycerol cholinephosphotransferase activity|cytidine diphosphocholine glyceride transferase activity|cytidine diphosphorylcholine diglyceride transferase activity|diacylglycerol choline phosphotransferase activity|phosphorylcholine--glyceride transferase activity|CDP-choline diglyceride phosphotransferase activity|CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity|1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity|1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity|cholinephosphotransferase activity|sn-1,2-diacylglycerol cholinephosphotransferase activity|CPT Reactome:R-HSA-1482961|EC:2.7.8.2|MetaCyc:RXN-5781|Reactome:R-HSA-1482973|RHEA:32939 molecular_function owl:Class
GO:0045023 biolink:NamedThing G0 to G1 transition The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression. got7fsn_ti biological_process owl:Class
GO:0060020 biolink:NamedThing Bergmann glial cell differentiation The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0019701 biolink:NamedThing peptidyl-arginine N5-methylation The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine. got7fsn_ti peptidyl-arginine delta-N-methylation RESID:AA0305 biological_process owl:Class
GO:0047505 biolink:NamedThing (-)-menthol monooxygenase activity Catalysis of the reaction: (-)-menthol + H(+) + NADPH + O(2) = 1,4-menthane-3,8-diol + H(2)O + NADP(+). got7fsn_ti l-menthol monooxygenase activity|(-)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating) EC:1.14.13.46|RHEA:11648|KEGG_REACTION:R02178|MetaCyc:--MENTHOL-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0140552 biolink:NamedThing TEAD-YAP complex A transcription factor complex that is composed of the one DNA binding protein of the TEAD family and the transcriptional coactivator YAP. got7fsn_ti TEAD-1-YAP complex|TEAD-3-YAP complex|TEAD-2 multiprotein complex|TEAD-4-YAP complex|TEAD-2-YAP complex https://github.com/geneontology/go-ontology/issues/9300 pg 2020-11-17T07:05:23Z GO:0071150|GO:0071147|GO:0071151|GO:0071149|GO:0071148 CORUM:2870 cellular_component owl:Class
GO:1990173 biolink:NamedThing protein localization to nucleoplasm A process in which a protein is transported to, or maintained in, a location within the nucleoplasm. got7fsn_ti nucleolus to nucleoplasm transport|protein localisation to nucleoplasm https://github.com/geneontology/go-ontology/issues/14690 mah 2013-08-23T15:01:16Z GO:0032066 biological_process owl:Class
GO:0034504 biolink:NamedThing protein localization to nucleus A process in which a protein transports or maintains the localization of another protein to the nucleus. got7fsn_ti protein localisation to nucleus|protein targeting to nucleus|protein localization in cell nucleus|protein localization in nucleus 2012-11-07T15:45:54Z GO:0044744 biological_process owl:Class
GO:0014074 biolink:NamedThing response to purine-containing compound Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus. got7fsn_ti response to purine biological_process owl:Class
GO:0018645 biolink:NamedThing alkene monooxygenase activity Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O. got7fsn_ti alkene epoxygenase activity|alkene,NADH:oxygen oxidoreductase activity EC:1.14.13.69|RHEA:11792|MetaCyc:1.14.13.69-RXN|UM-BBD_enzymeID:e0039 molecular_function owl:Class
GO:0033850 biolink:NamedThing Z-farnesyl diphosphate synthase activity Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-cis,6-trans-farnesyl diphosphate + diphosphate. got7fsn_ti geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase activity|(Z)-farnesyl diphosphate synthase activity EC:2.5.1.68|RHEA:23300|MetaCyc:2.5.1.68-RXN|KEGG_REACTION:R08528 molecular_function owl:Class
GO:0050047 biolink:NamedThing leucine 2,3-aminomutase activity Catalysis of the reaction: L-leucine = (3R)-beta-leucine. got7fsn_ti (2S)-alpha-leucine 2,3-aminomutase activity KEGG_REACTION:R01091|RHEA:10284|EC:5.4.3.7|MetaCyc:LEUCINE-23-AMINOMUTASE-RXN molecular_function owl:Class
GO:0018738 biolink:NamedThing S-formylglutathione hydrolase activity Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+). got7fsn_ti KEGG_REACTION:R00527|MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN|EC:3.1.2.12|UM-BBD_reactionID:r0241|RHEA:14961|Reactome:R-HSA-5693724 molecular_function owl:Class
GO:0050348 biolink:NamedThing trehalose O-mycolyltransferase activity Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose. got7fsn_ti alpha,alpha'-trehalose-6-mycolate:alpha,alpha'-trehalose-6-mycolate 6'-mycolyltransferase activity|alpha,alpha'-trehalose 6-monomycolate:alpha,alpha'-trehalose mycolyltransferase activity RHEA:23472|EC:2.3.1.122|KEGG_REACTION:R07248|MetaCyc:RXN1G-874 molecular_function owl:Class
GO:0097622 biolink:NamedThing cytoplasmic translational elongation through polyproline stretches The successive addition of amino acid residues to a nascent polypeptide chain, proceeding through regions of multiple repeated proline codons, during protein biosynthesis in the cytoplasm. got7fsn_ti pr 2014-08-06T16:29:10Z biological_process owl:Class
GO:0034432 biolink:NamedThing bis(5'-adenosyl)-pentaphosphatase activity Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. got7fsn_ti AP-5-A hydrolase activity|AP5A hydrolase activity|Ap5a pyrophosphohydrolase activity|diadenosine 5',5'''-P1,P6-pentaphosphate hydrolase activity|AP(5)A hydrolase activity molecular_function owl:Class
GO:0047542 biolink:NamedThing 2-furoyl-CoA dehydrogenase activity Catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+). got7fsn_ti 2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)|2-furoyl coenzyme A dehydrogenase activity|2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)|2-furoyl coenzyme A hydroxylase activity|furoyl-CoA hydroxylase activity KEGG_REACTION:R02987|RHEA:21480|MetaCyc:2-FUROYL-COA-DEHYDROGENASE-RXN|EC:1.3.99.8 molecular_function owl:Class
GO:0017059 biolink:NamedThing serine C-palmitoyltransferase complex An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine. got7fsn_ti cellular_component owl:Class
GO:0031211 biolink:NamedThing endoplasmic reticulum palmitoyltransferase complex A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue. got7fsn_ti cellular_component owl:Class
GO:0042382 biolink:NamedThing paraspeckles Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei. got7fsn_ti Wikipedia:Paraspeckle cellular_component owl:Class
GO:0015829 biolink:NamedThing valine transport The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-valine transport biological_process owl:Class
GO:0060930 biolink:NamedThing sinoatrial node cell fate commitment The commitment of cells to sinoatrial (SA) node cell fates and their capacity to differentiate into SA node cells. SA node cells are pacemaker cells that are found in the sinoatrial node. got7fsn_ti sinus node cell commitment|SAN cell commitment|SA node cell commitment dph 2009-09-29T12:03:38Z biological_process owl:Class
GO:0050226 biolink:NamedThing psychosine sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate. got7fsn_ti 3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase activity|PAPS:psychosine sulphotransferase activity|3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase activity|psychosine sulphotransferase activity MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN|RHEA:14137|EC:2.8.2.13 molecular_function owl:Class
GO:0003297 biolink:NamedThing heart wedging The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart. got7fsn_ti dph 2009-10-22T08:52:58Z biological_process owl:Class
GO:0002054 biolink:NamedThing nucleobase binding Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases. got7fsn_ti molecular_function owl:Class
GO:0004020 biolink:NamedThing adenylylsulfate kinase activity Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate. got7fsn_ti adenosine-5'-phosphosulfate-3'-phosphokinase activity|APS kinase activity|adenosine-5'-phosphosulfate 3'-phosphotransferase activity|adenosine-5'-phosphosulphate 3'-phosphotransferase activity|adenosine 5'-phosphosulfate kinase activity|adenylyl-sulfate kinase activity|adenylylsulfate kinase (phosphorylating)|5'-phosphoadenosine sulfate kinase activity|adenylyl-sulphate kinase activity|adenosine phosphosulfate kinase activity|ATP:adenylyl-sulfate 3'-phosphotransferase activity|adenosine phosphosulfokinase activity Reactome:R-HSA-3560785|EC:2.7.1.25|Reactome:R-HSA-174389|MetaCyc:ADENYLYLSULFKIN-RXN|RHEA:24152 molecular_function owl:Class
GO:1900204 biolink:NamedThing apoptotic process involved in metanephric collecting duct development Any apoptotic process that is involved in metanephric collecting duct development. got7fsn_ti programmed cell death by apoptosis of metanephric collecting duct development|apoptosis of metanephric collecting duct development|apoptotic process of metanephric collecting duct development|apoptotic programmed cell death of metanephric collecting duct development|apoptotic program of metanephric collecting duct development|apoptotic cell death of metanephric collecting duct development|signaling (initiator) caspase activity of metanephric collecting duct development|type I programmed cell death of metanephric collecting duct development yaf 2012-03-21T01:21:32Z biological_process owl:Class
GO:0018129 biolink:NamedThing peptidyl-oxazoline dehydrogenase activity Catalysis of the reduction of a peptide-linked oxazoline to oxazole. got7fsn_ti molecular_function owl:Class
GO:0140372 biolink:NamedThing histone H3 ubiquitination The modification of histone H3 by the addition of one or more ubiquitin groups. got7fsn_ti histone H3 ubiquitylation pg 2019-10-03T15:29:54Z biological_process owl:Class
GO:0004604 biolink:NamedThing phosphoadenylyl-sulfate reductase (thioredoxin) activity Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. got7fsn_ti thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity|thioredoxin:3'-phospho-adenylylsulfate reductase activity|adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)|PAdoPS reductase activity|PAPS reductase activity|PAPS reductase, thioredoxin-dependent activity|adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)|phosphoadenylyl-sulphate reductase (thioredoxin) activity|PAPS sulfotransferase activity|phosphoadenosine-phosphosulfate reductase activity|3'-phosphoadenylylsulfate reductase activity EC:1.8.4.8|MetaCyc:1.8.4.8-RXN|KEGG_REACTION:R02021|RHEA:11724 molecular_function owl:Class
GO:0005124 biolink:NamedThing scavenger receptor binding Binding to scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles. got7fsn_ti scavenger receptor ligand molecular_function owl:Class
GO:0071184 biolink:NamedThing protocadherin-alpha-v4-protocadherin-gamma-a1 complex A protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-a1, and is involved in the regulation of protein localization to the plasma membrane. got7fsn_ti Pcdhga1-Pcdha4 complex mah 2009-11-23T04:11:47Z cellular_component owl:Class
GO:0098768 biolink:NamedThing meiotic prometaphase I The meiotic cell cycle phase in eukaryotes between meiotic prophase I and meiotic metaphase I. During meiotic prometaphase I, the nuclear envelope breaks down and one kinetochore forms per chromosome. Chromosomes attach to spindle microtubules and begin to move towards the metaphase plate. got7fsn_ti This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0047074 biolink:NamedThing 4-hydroxycatechol 1,2-dioxygenase activity Catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate. got7fsn_ti MetaCyc:RXN-10137|RHEA:35595|MetaCyc:R308-RXN|EC:1.13.11.37 molecular_function owl:Class
GO:0007412 biolink:NamedThing axon target recognition The process in which an axon recognizes and binds to a set of cells with which it may form stable connections. got7fsn_ti biological_process owl:Class
GO:0062152 biolink:NamedThing mRNA (cytidine-5-)-methyltransferase activity Catalysis of the reaction: a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + H(+) + S-adenosyl-L-homocysteine. got7fsn_ti mRNA (cytosine-5-)-methyltransferase activity dph 2019-09-18T14:40:32Z RHEA:61464 molecular_function owl:Class
GO:0034522 biolink:NamedThing cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0774 molecular_function owl:Class
GO:0003137 biolink:NamedThing Notch signaling pathway involved in heart induction The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction. got7fsn_ti Notch signalling pathway involved in heart induction tb 2009-09-22T03:28:42Z biological_process owl:Class
GO:0007219 biolink:NamedThing Notch signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti Notch receptor signalling pathway|N signalling pathway|Notch receptor signaling pathway|Notch-receptor signalling pathway|N signaling pathway|Notch-receptor signaling pathway|Notch signalling pathway GO:0030179 Wikipedia:Notch_signaling_pathway biological_process owl:Class
GO:0043834 biolink:NamedThing trimethylamine methyltransferase activity Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine. got7fsn_ti trimethylamine:corrinoid methyltransferase activity|MT1|trimethylamine-specific methylcobalamin:coenzyme M methyltransferase activity|TMA methyltransferase 1|mttB1 This function is the first step in the pathway of methanogenesis from trimethylamine. MetaCyc:RXN-8102|RHEA:39287|EC:2.1.1.250 molecular_function owl:Class
GO:0008935 biolink:NamedThing 1,4-dihydroxy-2-naphthoyl-CoA synthase activity Catalysis of the reaction: 2-succinylbenzoyl-CoA + H+ = 1,4-dihydroxy-2-naphthoyl-CoA + H2O. got7fsn_ti naphthoate synthase activity|dihydroxynaphthoate synthase activity|DHNA synthetase activity|dihydroxynaphthoic acid synthetase activity|O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity https://github.com/geneontology/go-ontology/issues/21763 MetaCyc:NAPHTHOATE-SYN-RXN|EC:4.1.3.36|RHEA:26562|KEGG_REACTION:R04150 molecular_function owl:Class
GO:0102036 biolink:NamedThing methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity Catalysis of the reaction: a tetrahydrofolate + a [methyl-Co(III) corrinoid Fe-S protein] <=> an N5-methyl-tetrahydrofolate + a [Co(I) corrinoid Fe-S protein]. got7fsn_ti RHEA:45200|EC:2.1.1.258|MetaCyc:METHCOCLTH-RXN molecular_function owl:Class
GO:0051273 biolink:NamedThing beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds. got7fsn_ti beta-glucan metabolism biological_process owl:Class
GO:2001000 biolink:NamedThing regulation of xylan catabolic process Any process that modulates the frequency, rate or extent of xylan catabolic process. got7fsn_ti regulation of xylan catabolism|regulation of xylan degradation|regulation of xylan breakdown tt 2011-08-08T03:23:13Z biological_process owl:Class
GO:0045158 biolink:NamedThing electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II. got7fsn_ti cytochrome|cytochrome b6|cytochrome f|cytochrome b/b6 molecular_function owl:Class
GO:0045130 biolink:NamedThing keratan sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate. got7fsn_ti keratan sulfate Gal-6-sulfotransferase activity|3'-phosphoadenylylsulfate:keratan sulfotransferase activity|keratan sulphotransferase activity|3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase activity|3'-phosphoadenylyl keratan sulfotransferase activity|keratan sulfate sulfotransferase activity MetaCyc:KERATAN-SULFOTRANSFERASE-RXN|EC:2.8.2.21|Reactome:R-HSA-2046175 molecular_function owl:Class
GO:0051008 biolink:NamedThing Hsp27 protein binding Binding to Hsp27 proteins, a lightweight heat shock protein. got7fsn_ti molecular_function owl:Class
GO:0009849 biolink:NamedThing tryptophan-independent indoleacetic acid biosynthetic process The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan. got7fsn_ti tryptophan-independent IAA biosynthetic process|tryptophan-independent indoleacetic acid formation|tryptophan-independent indoleacetic acid biosynthesis|indoleacetic acid biosynthesis, tryptophan-independent|indoleacetic acid biosynthetic process, tryptophan-independent|tryptophan-independent indoleacetic acid synthesis|tryptophan-independent indoleacetic acid anabolism MetaCyc:PWY-581 biological_process owl:Class
GO:0031385 biolink:NamedThing regulation of termination of mating projection growth Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi. got7fsn_ti biological_process owl:Class
GO:0031383 biolink:NamedThing regulation of mating projection assembly Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi. got7fsn_ti regulation of mating projection biogenesis biological_process owl:Class
GO:1990733 biolink:NamedThing titin-telethonin complex A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils. got7fsn_ti Titin-Tcap complex An example of this are TTN and TCAP in human (UniProt symbols Q8WZ42 and O15273 respectively) in PMID:16407954 (inferred from direct assay). ame 2015-04-24T14:57:08Z cellular_component owl:Class
GO:0071461 biolink:NamedThing cellular response to redox state Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating redox state. Redox state refers to the balance of oxidized versus reduced forms of electron donors and acceptors in an organelle, cell or organ; plastoquinone, glutathione (GSH/GSSG), and nicotinamide nucleotides (NAD+/NADH and NADP+/NADPH) are among the most important. got7fsn_ti cellular redox signal response mah 2009-12-18T11:30:21Z biological_process owl:Class
GO:0016936 biolink:NamedThing galactoside binding Binding to a glycoside in which the sugar group is galactose. got7fsn_ti molecular_function owl:Class
GO:0044076 biolink:NamedThing positive regulation by symbiont of host vacuole organization The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism. got7fsn_ti positive regulation by symbiont of host vacuole biogenesis|positive regulation by symbiont of host vacuole organisation|positive regulation of host vacuole organization by symbiont biological_process owl:Class
GO:0008792 biolink:NamedThing arginine decarboxylase activity Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2). got7fsn_ti L-arginine carboxy-lyase (agmatine-forming)|L-arginine carboxy-lyase activity|SpeA EC:4.1.1.19|Reactome:R-HSA-350598|KEGG_REACTION:R00566|RHEA:17641|MetaCyc:ARGDECARBOX-RXN molecular_function owl:Class
GO:0047964 biolink:NamedThing glyoxylate reductase (NAD+) activity Catalysis of the reaction: glycolate + NAD+ = glyoxylate + NADH. got7fsn_ti glyoxylic acid reductase activity|glycolate reductase activity|NADH-dependent glyoxylate reductase activity RHEA:18229|MetaCyc:GLYCOLATE-REDUCTASE-RXN|EC:1.1.1.26 molecular_function owl:Class
GO:0010328 biolink:NamedThing auxin influx transmembrane transporter activity Enables the transfer of auxin, from one side of a membrane to the other, into a cell. got7fsn_ti auxin influx facilitator molecular_function owl:Class
GO:0140541 biolink:NamedThing piRNA transcription The cellular synthesis of Piwi-interacting RNA piRNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. got7fsn_ti Piwi-associated RNA transcription|PIWI-interacting RNA transcription https://github.com/geneontology/go-ontology/issues/19530 pg 2020-11-09T16:53:25Z biological_process owl:Class
GO:0005432 biolink:NamedThing calcium:sodium antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). got7fsn_ti sodium/calcium exchanger|sodium:calcium exchange|mitochondrial sodium/calcium ion exchange Reactome:R-HSA-8949703|RHEA:29255|Reactome:R-HSA-8949688|Reactome:R-HSA-425661 molecular_function owl:Class
GO:0002748 biolink:NamedThing antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR). got7fsn_ti antigen processing and presentation initiated by PRR mediated uptake of antigen|antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen biological_process owl:Class
GO:0061921 biolink:NamedThing peptidyl-lysine propionylation The propionylation of peptidyl-lysine. got7fsn_ti dph 2017-08-02T13:37:14Z biological_process owl:Class
GO:0044584 biolink:NamedThing cellodextrin binding Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers. got7fsn_ti jl 2012-04-24T04:52:05Z molecular_function owl:Class
GO:0018376 biolink:NamedThing peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16). got7fsn_ti See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. RESID:AA0026 biological_process owl:Class
GO:0035551 biolink:NamedThing protein initiator methionine removal involved in protein maturation Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein. got7fsn_ti bf 2010-05-13T04:29:05Z biological_process owl:Class
GO:0072581 biolink:NamedThing protein-N6-(L-lysyl)-L-lysine modification to protein-N6-(beta-lysyl)-L-lysine The modification of an N6-(lysyl)-L-lysine residue in a protein, producing protein-N6-(beta-lysyl)-L-lysine ((2S)-2-amino-6-([(2S)-2,6-diaminohexanoyl]amino)hexanoic acid). This modification is observed in, and is probably unique to, translation elongation factor P (EF-P). got7fsn_ti mah 2011-02-07T11:51:02Z biological_process owl:Class
GO:0051717 biolink:NamedThing inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Catalysis of the reaction: inositol-1,3,4,5-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate. got7fsn_ti inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity|inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase activity|inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase activity Reactome:R-HSA-1855200|Reactome:R-HSA-1855205|MetaCyc:3.1.3.62-RXN molecular_function owl:Class
GO:0035654 biolink:NamedThing clathrin-coated vesicle cargo loading, AP-3-mediated Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle. got7fsn_ti cargo loading into clathrin-coated vesicle, AP-3-mediated bf 2011-01-25T11:02:30Z biological_process owl:Class
GO:0090564 biolink:NamedThing protein-phosphocysteine-glucose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. got7fsn_ti tb 2014-04-08T15:03:08Z molecular_function owl:Class
GO:0002043 biolink:NamedThing blood vessel endothelial cell proliferation involved in sprouting angiogenesis The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis. got7fsn_ti blood vessel endothelial cell proliferation during sprouting angiogenesis biological_process owl:Class
GO:0071111 biolink:NamedThing cyclic-guanylate-specific phosphodiesterase activity Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+). got7fsn_ti VieA|cyclic bis(3->5')diguanylate phosphodiesterase activity|PDEA1|c-di-GMP-specific phosphodiesterase activity|c-di-GMP phosphodiesterase activity|phosphodiesterase A1 activity mah 2009-11-13T02:10:39Z KEGG_REACTION:R08991|EC:3.1.4.52|MetaCyc:RXN0-4181|RHEA:24902 molecular_function owl:Class
GO:0102429 biolink:NamedThing genistein-3-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: genistin + UDP-alpha-D-glucose <=> genistin 7-gentiobioside + UDP + H+. got7fsn_ti MetaCyc:RXN-13831 molecular_function owl:Class
GO:0071209 biolink:NamedThing U7 snRNA binding Binding to a U7 small nuclear RNA (U7 snRNA). got7fsn_ti Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). mah 2009-11-25T01:46:50Z molecular_function owl:Class
GO:0120108 biolink:NamedThing DNA-3'-diphospho-5'-guanosine diphosphatase Catalysis of the reaction: (DNA)-3'-diphospho-5'-guanosine + H(2)O <=> (DNA)-3'-phosphate + GMP. got7fsn_ti DNA-3'pp5'G guanylate hydrolase krc 2017-10-17T22:12:59Z EC:3.6.1.72|RHEA:52140 molecular_function owl:Class
GO:0046946 biolink:NamedThing hydroxylysine metabolic process The chemical reactions and pathways involving hydroxylysine (5-hydroxy-2,6-diaminohexanoic acid), a chiral alpha-amino acid. Hydroxylysine is found in collagen and commonly has galactose and then glucose added sequentially by glycosyltransferases. got7fsn_ti hydroxylysine metabolism biological_process owl:Class
GO:0032580 biolink:NamedThing Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. got7fsn_ti Golgi stack membrane cellular_component owl:Class
GO:0017040 biolink:NamedThing N-acylsphingosine amidohydrolase activity Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. got7fsn_ti acylsphingosine deacylase activity|glycosphingolipid ceramide deacylase|N-acylsphingosine amidohydrolase activity Reactome:R-HSA-1606583|Reactome:R-HSA-428231|RHEA:20856|EC:3.5.1.23|Reactome:R-HSA-428205|Reactome:R-HSA-1606602|MetaCyc:CERAMIDASE-RXN molecular_function owl:Class
GO:0008726 biolink:NamedThing alkanesulfonate monooxygenase activity Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN. got7fsn_ti FMNH2-dependent aliphatic sulfonate monooxygenase activity|FMNH(2)-dependent alkanesulfonate monooxygenase activity|FMNH(2)-dependent aliphatic sulfonate monooxygenase activity|alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity|sulfate starvation-induced protein 6 activity|SsuD|alkanesulphonate monooxygenase activity MetaCyc:RXN0-280|EC:1.14.14.5|RHEA:23064 molecular_function owl:Class
GO:0050581 biolink:NamedThing D-mannitol oxidase activity Catalysis of the reaction: mannitol + O2 = mannose + H2O2. got7fsn_ti mannitol oxidase activity|D-arabinitol oxidase activity|mannitol:oxygen oxidoreductase (cyclizing)|D-arabitol oxidase activity RHEA:18513|MetaCyc:1.1.3.40-RXN|EC:1.1.3.40 molecular_function owl:Class
GO:0004083 biolink:NamedThing bisphosphoglycerate 2-phosphatase activity Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate. got7fsn_ti 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity KEGG_REACTION:R01516|RHEA:21904|MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN molecular_function owl:Class
GO:0046336 biolink:NamedThing ethanolamine catabolic process The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine). got7fsn_ti ethanolamine degradation|ethanolamine catabolism|ethanolamine breakdown biological_process owl:Class
GO:0140562 biolink:NamedThing EGF-domain serine xylosyltransferase activity Catalyses the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(beta-D-xylosyl)-L-serine. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16869 pg 2020-11-25T14:30:56Z RHEA:62016|EC:2.4.2.63 molecular_function owl:Class
GO:0047886 biolink:NamedThing farnesol dehydrogenase activity Catalysis of the reaction: 2-trans,6-trans-farnesol + NADP(+) = 2-trans,6-trans-farnesal + H(+) + NADPH. got7fsn_ti NADP-farnesol dehydrogenase activity|farnesol (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|2-trans,6-trans-farnesol:NADP+ 1-oxidoreductase activity RHEA:14697|EC:1.1.1.216|KEGG_REACTION:R03264|MetaCyc:FARNESOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0050026 biolink:NamedThing L-glycol dehydrogenase activity Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+. got7fsn_ti L-glycol:NAD(P)+ oxidoreductase activity|glycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity|L-(+)-glycol:NAD(P) oxidoreductase activity|L-glycol:NAD(P) dehydrogenase activity MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN|EC:1.1.1.185 molecular_function owl:Class
GO:1990120 biolink:NamedThing messenger ribonucleoprotein complex assembly The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex. got7fsn_ti mRNP assembly|messenger ribonucleoprotein assembly|mRNP complex assembly|mRNA-protein complex assembly rb 2013-06-11T21:18:20Z biological_process owl:Class
GO:2001042 biolink:NamedThing negative regulation of septum digestion after cytokinesis Any process that stops, prevents or reduces the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. got7fsn_ti negative regulation of cytokinetic cell separation mcc 2011-08-30T05:16:55Z biological_process owl:Class
GO:0070139 biolink:NamedThing SUMO-specific endopeptidase activity Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within the small conjugating protein SUMO. got7fsn_ti Reactome:R-HSA-2993763|Reactome:R-HSA-2990840|Reactome:R-HSA-2990842 molecular_function owl:Class
GO:0050138 biolink:NamedThing nicotinate dehydrogenase activity Catalysis of the reaction: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH. got7fsn_ti nicotinate:NADP+ 6-oxidoreductase (hydroxylating)|nicotinate hydroxylase activity|nicotinic acid hydroxylase activity RHEA:12236|MetaCyc:NICOTINATE-DEHYDROGENASE-RXN|EC:1.17.1.5|KEGG_REACTION:R01720|MetaCyc:RXN-7637 molecular_function owl:Class
GO:0021824 biolink:NamedThing cerebral cortex tangential migration using cell-axon interactions The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons. got7fsn_ti biological_process owl:Class
GO:0050606 biolink:NamedThing 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH. got7fsn_ti 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP(+) oxidoreductase activity|2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase activity|4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase activity|alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase activity KEGG_REACTION:R04279|EC:1.1.1.312|RHEA:29587|MetaCyc:1.2.1.45-RXN molecular_function owl:Class
GO:0042305 biolink:NamedThing specification of segmental identity, mandibular segment The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti See also the fly_anatomy.ontology term 'mandibular segment ; FBbt:00000012'. biological_process owl:Class
GO:0050173 biolink:NamedThing phenylalanine adenylyltransferase activity Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H(+). got7fsn_ti ATP:L-phenylalanine adenylyltransferase activity|ATP:phenylalanine adenylyltransferase activity|L-phenylalanine adenylyltransferase activity MetaCyc:PHENYLALANINE-ADENYLYLTRANSFERASE-RXN|RHEA:17189|EC:2.7.7.54|KEGG_REACTION:R00687 molecular_function owl:Class
GO:0052883 biolink:NamedThing tyrosine ammonia-lyase activity Catalysis of the reaction: L-tyrosine = NH(4)(+) + trans-4-coumarate. got7fsn_ti TAL activity|tyrase activity|L-tyrosine ammonia-lyase activity RHEA:24906|EC:4.3.1.25|EC:4.3.1.23 molecular_function owl:Class
GO:0009116 biolink:NamedThing nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). got7fsn_ti nucleoside metabolism biological_process owl:Class
GO:0006105 biolink:NamedThing succinate metabolic process The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle. got7fsn_ti succinate metabolism biological_process owl:Class
GO:0102948 biolink:NamedThing luteolin C-glucosyltransferase activity Catalysis of the reaction: 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-olate luteolin-7-olate + a glucosylated glucose acceptor = isoorientin + a non glucosylated glucose acceptor. got7fsn_ti MetaCyc:RXN-9081 molecular_function owl:Class
GO:0046936 biolink:NamedThing 2'-deoxyadenosine deaminase activity Catalysis of the reaction: 2'-deoxyadenosine + H2O = deoxyinosine + NH3. got7fsn_ti deoxyadenosine deaminase reaction MetaCyc:ADDALT-RXN|RHEA:28190 molecular_function owl:Class
GO:0014914 biolink:NamedThing myoblast maturation involved in muscle regeneration A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0048628 biolink:NamedThing myoblast maturation A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0047584 biolink:NamedThing 4-oxalmesaconate hydratase activity Catalysis of the reaction: 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate + H(2)O. got7fsn_ti 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase [(E)-4-oxobut-1-ene-1,2,4-tricarboxylate-forming]|gamma-oxalmesaconate hydratase activity|oxalmesaconate hydratase activity|4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity|4-carboxy-2-oxohexenedioate hydratase activity|2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase activity MetaCyc:RXN-2463|EC:4.2.1.83|KEGG_REACTION:R04478|RHEA:17401 molecular_function owl:Class
GO:0106096 biolink:NamedThing response to ceramide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ceramide stimulus. got7fsn_ti hjd 2018-02-12T19:48:43Z biological_process owl:Class
GO:0033993 biolink:NamedThing response to lipid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. got7fsn_ti biological_process owl:Class
GO:0052881 biolink:NamedThing 4-hydroxyphenylacetate 3-monooxygenase activity Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O. got7fsn_ti 4 HPA 3-hydroxylase activity|4-hydroxyphenylacetic acid-3-hydroxylase activity|p-hydroxyphenylacetate 3-hydroxylase activity|4-hydroxyphenylacetate,FADH:oxygen oxidoreductase (3-hydroxylating) activity|p-hydroxyphenylacetate 3-hydroxylase (FAD) activity|p-hydroxyphenylacetate hydroxylase activity|p-hydroxyphenylacetate hydroxylase (FAD) activity UM-BBD_reactionID:r0301|EC:1.14.14.9|RHEA:30595|MetaCyc:RXN-8505 molecular_function owl:Class
GO:0097270 biolink:NamedThing dishabituation The temporary recovery of response to a stimulus when a novel stimulus is added. got7fsn_ti pr 2012-03-20T01:39:25Z biological_process owl:Class
GO:0048188 biolink:NamedThing Set1C/COMPASS complex A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. got7fsn_ti Set1/COMPASS complex|Set1C|COMPASS complex cellular_component owl:Class
GO:0018234 biolink:NamedThing peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase. got7fsn_ti RESID:AA0113 biological_process owl:Class
GO:0004052 biolink:NamedThing arachidonate 12(S)-lipoxygenase activity Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. got7fsn_ti C-12 lipoxygenase activity|12Delta-lipoxygenase activity|delta12-lipoxygenase activity|12S-lipoxygenase activity|arachidonate:oxygen 12-oxidoreductase activity|12-lipoxygenase activity|LTA4 synthase activity|leukotriene A4 synthase Reactome:R-HSA-9024983|Reactome:R-HSA-2161948|MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN|Reactome:R-HSA-2161964|Reactome:R-HSA-9026006|Reactome:R-HSA-9025957|Reactome:R-HSA-2161950|EC:1.13.11.31|KEGG_REACTION:R01596|Reactome:R-HSA-9026007|RHEA:10428 molecular_function owl:Class
GO:0007142 biolink:NamedThing male meiosis II A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline. got7fsn_ti male meiosis II nuclear division biological_process owl:Class
GO:0060313 biolink:NamedThing negative regulation of blood vessel remodeling Any process that decreases the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels. got7fsn_ti inhibition of blood vessel remodeling|down-regulation of blood vessel remodeling biological_process owl:Class
GO:0047353 biolink:NamedThing N-methylphosphoethanolamine cytidylyltransferase activity Catalysis of the reaction: N-methylethanolamine phosphate + CTP = CDP-N-methylethanolamine + diphosphate. got7fsn_ti CTP:P-MEA cytidylyltransferase activity|CTP:N-methylethanolamine-phosphate cytidylyltransferase activity|CTP:N-methylphosphoethanolamine cytidylyltransferase activity|monomethylethanolamine phosphate cytidylyltransferase activity EC:2.7.7.57|RHEA:10576|KEGG_REACTION:R03375|MetaCyc:2.7.7.57-RXN molecular_function owl:Class
GO:0140702 biolink:NamedThing cyclic GMP-AMP binding Binding to cyclic GMP-AMP (cGAMP) nucleotide. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21980 pg 2021-08-27T05:39:31Z molecular_function owl:Class
GO:0032457 biolink:NamedThing fast endocytic recycling The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport. got7fsn_ti direct endocytic recycling biological_process owl:Class
GO:0050236 biolink:NamedThing pyridoxine:NADP 4-dehydrogenase activity Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal. got7fsn_ti pyridoxin dehydrogenase activity|pyridoxol dehydrogenase activity|pyridoxine dehydrogenase activity|pyridoxine:NADP 4-oxidoreductase activity|pyridoxal reductase activity|PL reductase activity MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN|RHEA:16129|KEGG_REACTION:R01708|EC:1.1.1.65 molecular_function owl:Class
GO:1990355 biolink:NamedThing L-methionine salvage from methionine sulphoxide The generation of L-methionine from methionine sulphoxide. got7fsn_ti methionine salvage from methionine sulphoxide al 2014-04-02T12:55:01Z biological_process owl:Class
GO:0047385 biolink:NamedThing [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity Catalysis of the reaction: H2O + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate = phosphate + [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]. got7fsn_ti branched-chain 2-keto acid dehydrogenase phosphatase activity|branched-chain oxo-acid dehydrogenase phosphatase activity|3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphatase activity|3-methyl-2-oxobutanoate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity|branched-chain alpha-keto acid dehydrogenase phosphatase EC:3.1.3.52|MetaCyc:3.1.3.52-RXN molecular_function owl:Class
GO:0071606 biolink:NamedThing chemokine (C-C motif) ligand 4 production The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti MIP-1b production|CCL4 production|macrophage inflammatory protein production mah 2010-02-05T04:16:42Z biological_process owl:Class
GO:0042612 biolink:NamedThing MHC class I protein complex A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules. got7fsn_ti See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'. cellular_component owl:Class
GO:0097515 biolink:NamedThing asexual spore wall A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species. got7fsn_ti pr 2013-10-16T15:11:21Z cellular_component owl:Class
GO:0034216 biolink:NamedThing high-affinity thiamine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high-affinity thiamin:hydrogen symporter activity|high affinity thiamin:hydrogen symporter activity|high-affinity thiamine:hydrogen symporter activity|high-affinity thiamin:proton symporter activity molecular_function owl:Class
GO:0034215 biolink:NamedThing thiamine:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: thiamine(out) + H+(out) = thiamine(in) + H+(in). got7fsn_ti thiamin:proton symporter activity|thiamine:hydrogen symporter activity|thiamin:hydrogen symporter activity molecular_function owl:Class
GO:0050471 biolink:NamedThing uracilylalanine synthase activity Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate. got7fsn_ti 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity|O3-acetyl-L-serine acetate-lyase (adding uracil)|O(3)-acetyl-L-serine acetate-lyase (adding uracil) activity|Willardiine synthase activity|isowillardiine synthase activity|O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase activity RHEA:11496|EC:2.5.1.53|MetaCyc:URACILYLALANINE-SYNTHASE-RXN molecular_function owl:Class
GO:0018425 biolink:NamedThing O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds. got7fsn_ti O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis|O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation|O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism|O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis RESID:AA0296 biological_process owl:Class
GO:0102884 biolink:NamedThing alpha-zingiberene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> zingiberene + diphosphoric acid. got7fsn_ti RHEA:28643|MetaCyc:RXN-8425|EC:4.2.3.65 molecular_function owl:Class
GO:0070353 biolink:NamedThing GATA1-TAL1-TCF3-Lmo2 complex A protein complex that contains the zinc finger transcription factor GATA1, the LIM domain protein Lmo2 (RBTN2), the basic helix-loop-helix protein TAL1 and its binding partner TCF3. The complex is involved transcriptional regulation in hematopoiesis. got7fsn_ti cellular_component owl:Class
GO:0019281 biolink:NamedThing L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine. got7fsn_ti L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine|methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine|L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine|L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine MetaCyc:MET-SAM-PWY biological_process owl:Class
GO:0007614 biolink:NamedThing short-term memory The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. got7fsn_ti Wikipedia:Short-term_memory biological_process owl:Class
GO:1990687 biolink:NamedThing endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport. got7fsn_ti ER-derived vesicle fusion with ER-Golgi intermediate compartment membrane|ER-derived vesicle fusion with ERGIC membrane bhm 2015-03-12T09:31:45Z biological_process owl:Class
GO:0071958 biolink:NamedThing new mitotic spindle pole body The spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize. got7fsn_ti new SPB mah 2011-06-01T02:34:34Z cellular_component owl:Class
GO:0001162 biolink:NamedThing RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. got7fsn_ti To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. krc 2011-01-28T03:46:19Z molecular_function owl:Class
GO:0043728 biolink:NamedThing 2-keto-4-methylthiobutyrate aminotransferase activity Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine. got7fsn_ti EC:4.1.1.- molecular_function owl:Class
GO:0008111 biolink:NamedThing alpha-methylacyl-CoA racemase activity Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA. got7fsn_ti 2-methylacyl-CoA 2-epimerase activity Reactome:R-HSA-193452|Reactome:R-HSA-193736|Reactome:R-HSA-193763|EC:5.1.99.4|Reactome:R-HSA-389897|Reactome:R-HSA-192056|RHEA:12657|MetaCyc:5.1.99.4-RXN molecular_function owl:Class
GO:0050010 biolink:NamedThing isovitexin beta-glucosyltransferase activity Catalysis of the reaction: isovitexin + UDP-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP. got7fsn_ti isovitexin b-glucosyltransferase activity|uridine diphosphoglucose-isovitexin 2''-glucosyltransferase activity|UDP-glucose:isovitexin 2''-O-beta-D-glucosyltransferase activity|UDPglucose:isovitexin 2''-O-beta-D-glucosyltransferase activity KEGG_REACTION:R03686|RHEA:19529|MetaCyc:ISOVITEXIN-BETA-GLUCOSYLTRANSFERASE-RXN|EC:2.4.1.106 molecular_function owl:Class
GO:0002318 biolink:NamedThing myeloid progenitor cell differentiation The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages. got7fsn_ti biological_process owl:Class
GO:0018574 biolink:NamedThing 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate. got7fsn_ti UM-BBD_enzymeID:e0422|EC:1.13.11.- molecular_function owl:Class
GO:0044656 biolink:NamedThing regulation of post-lysosomal vacuole size Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis. got7fsn_ti regulation of post-lysosome size jl 2012-07-26T04:30:56Z biological_process owl:Class
GO:0102396 biolink:NamedThing 9-cis-10'-apo-beta-carotenal cleavage oxygenase activity Catalysis of the reaction: 9-cis-10'-apo-beta-carotenal + 2 O2 <=> carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal. got7fsn_ti RHEA:34403|EC:1.13.11.69|MetaCyc:RXN-13643 molecular_function owl:Class
GO:0140464 biolink:NamedThing silent mating-type cassette heterochromatin organization The organization of chromatin into heterochromatin at a silent mating-type cassette locus. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19396 pg 2020-05-13T05:13:24Z biological_process owl:Class
GO:0150062 biolink:NamedThing complement-mediated synapse pruning Synaptic pruning mediated by complement system signalling. got7fsn_ti synapse elimination|synapse clearance|synapse disassembly|synapse removal|complement-dependent synapse pruning bc 2018-07-16T17:44:59Z biological_process owl:Class
GO:0098883 biolink:NamedThing synapse pruning A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. got7fsn_ti synapse clearance|synapse disassembly|synapse removal|synapse elimination biological_process owl:Class
GO:0052846 biolink:NamedThing inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+. got7fsn_ti ai 2011-12-05T11:02:23Z MetaCyc:RXN-10965 molecular_function owl:Class
GO:0033299 biolink:NamedThing secretion of lysosomal enzymes The controlled release of lysosomal enzymes by a cell. got7fsn_ti biological_process owl:Class
GO:0102725 biolink:NamedThing 24-methyldesmosterol reductase activity Catalysis of the reaction: H+ + 24-methyldesmosterol + NADPH = campesterol + NADP. got7fsn_ti MetaCyc:RXN-708 molecular_function owl:Class
GO:0006978 biolink:NamedThing DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage. got7fsn_ti biological_process owl:Class
GO:0047374 biolink:NamedThing methylumbelliferyl-acetate deacetylase activity Catalysis of the reaction: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate + H(+). got7fsn_ti 4-methylumbelliferyl-acetate acylhydrolase activity|esterase D activity KEGG_REACTION:R04141|RHEA:12208|EC:3.1.1.56|MetaCyc:3.1.1.56-RXN molecular_function owl:Class
GO:0018575 biolink:NamedThing chlorocatechol 1,2-dioxygenase activity Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate. got7fsn_ti UM-BBD_reactionID:r0655|EC:1.13.11.- molecular_function owl:Class
GO:0098621 biolink:NamedThing phosphoseryl-selenocysteinyl-tRNA selenium transferase activity Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid. got7fsn_ti RHEA:25041|Reactome:R-HSA-2408555|EC:2.9.1.2 molecular_function owl:Class
GO:0140037 biolink:NamedThing sumo-dependent protein binding Binding to a protein upon sumoylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require sumoylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of sumoylation. It may be that the sumoylation causes a conformational change that allows binding of the protein to another region; this type of sumoylation-dependent protein binding is valid for annotation to this term. pg 2017-05-18T06:29:27Z molecular_function owl:Class
GO:0102839 biolink:NamedThing 1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.35|MetaCyc:RXN-8299 molecular_function owl:Class
GO:0021949 biolink:NamedThing brainstem precerebellar neuron precursor migration The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem. got7fsn_ti biological_process owl:Class
GO:0016964 biolink:NamedThing alpha-2 macroglobulin receptor activity Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis. got7fsn_ti molecular_function owl:Class
GO:0102351 biolink:NamedThing gamma-aminobutyrate transaminase (glyoxylate dependent) activity Catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine. got7fsn_ti EC:2.6.1.96|RHEA:32267|MetaCyc:RXN-13328 molecular_function owl:Class
GO:0070180 biolink:NamedThing large ribosomal subunit rRNA binding Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. got7fsn_ti 25S rRNA binding|LSU rRNA binding molecular_function owl:Class
GO:0002563 biolink:NamedThing somatic diversification of immune receptors via alternate splicing The process in which immune receptor genes are diversified through alternate splicing. got7fsn_ti biological_process owl:Class
GO:0010506 biolink:NamedThing regulation of autophagy Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. got7fsn_ti biological_process owl:Class
GO:0106213 biolink:NamedThing kinetochore disassembly involved in meiotic chromosome organization The cell cycle process in which outer kinetochore components delocalize from the centromere, contributing to the rearrangement of chromosomes into the orientation characteristic of meiotic prophase I. got7fsn_ti kinetochore disassembly from spindle pole body involved in chromosome organization involved in meiotic cell cycle hjd 2019-06-25T18:31:06Z biological_process owl:Class
GO:0120043 biolink:NamedThing stereocilium shaft The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle. got7fsn_ti krc 2017-05-15T20:38:32Z cellular_component owl:Class
GO:0097583 biolink:NamedThing dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p. got7fsn_ti Pmt1p-Pmt3p complex pr 2014-03-02T18:16:29Z cellular_component owl:Class
GO:0097455 biolink:NamedThing spiny bracelet of Nageotte Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin. got7fsn_ti pr 2012-12-19T13:02:33Z NIF_Subcellular:sao937871668 cellular_component owl:Class
GO:0050192 biolink:NamedThing phosphoglycerate phosphatase activity Catalysis of the reaction: 2-phospho-D-glycerate + H(2)O = D-glycerate + phosphate. got7fsn_ti D-2-phosphoglycerate phosphatase activity|glycerophosphate phosphatase activity|D-glycerate-2-phosphate phosphohydrolase activity RHEA:21156|KEGG_REACTION:R01748|MetaCyc:PHOSPHOGLYCERATE-PHOSPHATASE-RXN|EC:3.1.3.20 molecular_function owl:Class
GO:0000236 biolink:NamedThing mitotic prometaphase The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0031470 biolink:NamedThing carboxysome An organelle consisting of a proteinaceous coat and enzymes for the fixation of CO(2). It augments the concentration of CO(2) in the vicinity of RuBisCO to increase the efficiency of CO(2) fixation under atmospheric conditions. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19743 Wikipedia:Carboxysome cellular_component owl:Class
GO:0052850 biolink:NamedThing NADPH-dependent dihydrocurcumin reductase activity Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+. got7fsn_ti dihydrocurcumin reductase (NADPH) activity ai 2011-12-05T11:04:23Z MetaCyc:RXN0-6677 molecular_function owl:Class
GO:0090589 biolink:NamedThing protein-phosphocysteine-trehalose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0070945 biolink:NamedThing neutrophil-mediated killing of gram-negative bacterium The directed killing of a gram-negative bacterium by a neutrophil. got7fsn_ti neutrophil mediated killing of gram-negative bacterium mah 2009-10-01T01:59:12Z biological_process owl:Class
GO:0043120 biolink:NamedThing tumor necrosis factor binding Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. got7fsn_ti molecular_function owl:Class
GO:0072685 biolink:NamedThing Mre11 complex assembly The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling. got7fsn_ti MRN complex assembly|MRX complex assembly|RMX complex assembly|Rad50 complex assembly|Rad50-Rad32-Nbs1 complex assembly|RAD50-MRE11-NBN complex assembly mah 2011-05-12T02:52:06Z biological_process owl:Class
GO:0052658 biolink:NamedThing inositol-1,4,5-trisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. got7fsn_ti inosine triphosphatase activity|inositol triphosphate 5-phosphomonoesterase activity|inositol trisphosphate phosphomonoesterase activity|inositol polyphosphate-5-phosphatase activity|L-myo-inositol 1,4,5-trisphosphate-monoesterase activity|inositol 1,4,5-trisphosphate phosphatase activity|InsP3 5-phosphatase activity|type I inositol-polyphosphate phosphatase activity|inositol phosphate 5-phosphomonoesterase activity|D-myo-inositol(1,4,5)-trisphosphate 5-phosphatase activity|1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity|Ins(1,4,5)P3 5-phosphatase activity|myo-inositol-1,4,5-trisphosphate 5-phosphatase activity|D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity|InsP(3) 5-phosphatase activity|type II inositol polyphosphate 5-phosphatase activity|5PTase activity|D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity Reactome:R-HSA-1855174|KEGG_REACTION:R03394|EC:3.1.3.56|RHEA:19797|Reactome:R-HSA-1855222|MetaCyc:3.1.3.56-RXN molecular_function owl:Class
GO:0106332 biolink:NamedThing ds/ssDNA junction-specific dsDNA endonuclease activity Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction. got7fsn_ti hjd 2020-10-08T18:09:57Z molecular_function owl:Class
GO:0036289 biolink:NamedThing peptidyl-serine autophosphorylation The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein. got7fsn_ti serine autophosphorylation bf 2012-07-18T10:24:32Z biological_process owl:Class
GO:0043450 biolink:NamedThing alkene biosynthetic process The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n. got7fsn_ti alkene formation|alkene anabolism|alkene biosynthesis|alkene synthesis biological_process owl:Class
GO:0106361 biolink:NamedThing protein-arginine rhamnosyltransferase activity Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl-[protein] = dTDP + H(+) + N(omega)-(L-rhamnosyl)-L-arginyl-[protein]. got7fsn_ti hjd 2021-02-05T15:39:52Z RHEA:66692 molecular_function owl:Class
GO:0047549 biolink:NamedThing 2-nitrophenol 2-monooxygenase activity Catalysis of the reaction: 2-nitrophenol + 2 H(+) + 2 NADPH + O(2) = catechol + H(2)O + 2 NADP(+) + nitrite. got7fsn_ti 2-nitrophenol oxygenase activity|2-nitrophenol,NADPH:oxygen 2-oxidoreductase (2-hydroxylating, nitrite-forming)|nitrophenol oxygenase activity MetaCyc:2-NITROPHENOL-2-MONOOXYGENASE-RXN|UM-BBD_reactionID:r1494|RHEA:19457|KEGG_REACTION:R00828|EC:1.14.13.31 molecular_function owl:Class
GO:0047632 biolink:NamedThing agmatine deiminase activity Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3. got7fsn_ti agmatine iminohydrolase activity|agmatine amidinohydrolase RHEA:18037|EC:3.5.3.12|MetaCyc:AGMATINE-DEIMINASE-RXN molecular_function owl:Class
GO:0044622 biolink:NamedThing negative regulation of cell migration in other organism Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism. got7fsn_ti jl 2012-07-04T04:42:14Z biological_process owl:Class
GO:0010644 biolink:NamedThing cell communication by electrical coupling The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels. got7fsn_ti biological_process owl:Class
GO:0050605 biolink:NamedThing superoxide reductase activity Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin. got7fsn_ti rubredoxin:superoxide oxidoreductase activity|desulfoferrodoxin activity|neelaredoxin activity RHEA:21324|EC:1.15.1.2|MetaCyc:1.15.1.2-RXN molecular_function owl:Class
GO:0031850 biolink:NamedThing delta-type opioid receptor binding Binding to a delta-type opioid receptor. got7fsn_ti enkephalin receptor binding|delta-type opioid receptor ligand molecular_function owl:Class
GO:0102047 biolink:NamedThing indole-3-acetyl-glycine synthetase activity Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10429 molecular_function owl:Class
GO:0018532 biolink:NamedThing 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin. got7fsn_ti coenzyme F420-independent methylene-H4MPT dehydrogenase activity|coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity|F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity|F420-independent methylene-H4MPT dehydrogenase activity EC:1.5.99.-|UM-BBD_reactionID:r0353 molecular_function owl:Class
GO:0046845 biolink:NamedThing branched duct epithelial cell fate determination, open tracheal system Allocation of a set number of cells to each primary branch in an open tracheal system, prior to the onset of cell migration. This establishes different domains of cells within the tracheal placode. got7fsn_ti branch cell fate determination biological_process owl:Class
GO:0018863 biolink:NamedThing phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene. got7fsn_ti EC:3.3.2.-|UM-BBD_reactionID:r0496 molecular_function owl:Class
GO:0046541 biolink:NamedThing saliva secretion The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin. got7fsn_ti salivation Wikipedia:Salivation biological_process owl:Class
GO:0032793 biolink:NamedThing positive regulation of CREB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB. got7fsn_ti activation of CREB|activation of CREB transcription factor|CREB activator biological_process owl:Class
GO:0106218 biolink:NamedThing galactosaminogalactan biosynthetic process The chemical reactions and pathways resulting in the formation of the exopolysaccharide galactosaminogalactan. GAG is a heteropolysaccharide composed of alpha-1,4 linked galactose, N-acetyl galactosamine (GalNAc) and galactosamine (GalN). got7fsn_ti galactosaminogalactan anabolism|GAG biosynthetic process|galactosaminogalactan synthesis|galactosaminogalactan formation|galactosaminogalactan biosynthesis hjd 2019-08-05T14:46:56Z biological_process owl:Class
GO:0102939 biolink:NamedThing 3-methoxy-5-hydroxytoluene O-methyltransferase activity Catalysis of the reaction: 3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine = H+ + 3,5-dimethoxytoluene + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-9018 molecular_function owl:Class
GO:0018729 biolink:NamedThing propionate CoA-transferase activity Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA. got7fsn_ti propionyl CoA:acetate CoA transferase activity|propionyl-CoA transferase activity|propionate-CoA:lactoyl-CoA transferase activity|acetyl-CoA:propanoate CoA-transferase activity|propionate coenzyme A-transferase activity EC:2.8.3.1|RHEA:23520|UM-BBD_reactionID:r0087|MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN molecular_function owl:Class
GO:0035872 biolink:NamedThing nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process. got7fsn_ti nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway|nucleotide-binding domain leucine-rich repeat containing receptor signaling pathway|NOD-like receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signal transduction|NLR signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway bf 2011-05-26T03:30:36Z biological_process owl:Class
GO:0006528 biolink:NamedThing asparagine metabolic process The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid. got7fsn_ti asparagine metabolism MetaCyc:ASPARAGINESYN-PWY biological_process owl:Class
GO:0060021 biolink:NamedThing roof of mouth development The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. got7fsn_ti palatum development biological_process owl:Class
GO:0035160 biolink:NamedThing maintenance of epithelial integrity, open tracheal system Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process. got7fsn_ti maintenance of tracheal epithelial integrity biological_process owl:Class
GO:0031736 biolink:NamedThing CCR11 chemokine receptor binding Binding to a CCR11 chemokine receptor. got7fsn_ti CCR11 chemokine receptor ligand molecular_function owl:Class
GO:0036357 biolink:NamedThing 2-phosphoglycerate kinase activity Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP. got7fsn_ti 2PGK activity This reaction is the first step in the biosynthesis of cyclic 2,3-diphosphoglycerate (cDPG). bf 2012-09-19T15:06:25Z EC:2.7.2.- molecular_function owl:Class
GO:1990116 biolink:NamedThing ribosome-associated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein. got7fsn_ti ribosome-associated degradation|RAD|ribosome-associated ubiquitin-dependent protein degradation|ribosome-associated ubiquitin-dependent protein breakdown|ribosome-associated ubiquitin-dependent protein catabolism pr 2013-06-05T11:46:01Z biological_process owl:Class
GO:0021673 biolink:NamedThing rhombomere 7 formation The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0003911 biolink:NamedThing DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). got7fsn_ti deoxyribonucleic acid ligase|polynucleotide synthetase (nicotinamide adenine dinucleotide)|polynucleotide ligase|polynucleotide synthetase activity|DNA-joining enzyme|deoxyribonucleic ligase|DNA joinase activity|deoxyribonucleic-joining enzyme|deoxyribonucleate ligase|deoxyribonucleic joinase|DNA ligase (NAD)|polynucleotide ligase (NAD)|poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)|polynucleotide ligase (NAD(+)) activity|Polydeoxyribonucleotide synthase (NAD(+)) activity|polynucleotide ligase (nicotinamide adenine dinucleotide)|polydeoxyribonucleotide synthase (NAD+) activity|DNA repair enzyme activity|polydeoxyribonucleotide synthase (NAD)|polynucleotide ligase (NAD+) activity|deoxyribonucleic repair enzyme|deoxyribonucleic acid joinase MetaCyc:DNA-LIGASE-NAD+-RXN|EC:6.5.1.2 molecular_function owl:Class
GO:0003700 biolink:NamedThing DNA-binding transcription factor activity A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. got7fsn_ti bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity|metal ion regulated sequence-specific DNA binding transcription factor activity|transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding|DNA binding transcription factor activity|bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding|transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding|bacterial-type DNA binding transcription factor activity|gene-specific transcription factor activity|metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity|bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding|nucleic acid binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor activity, metal ion regulated sequence-specific DNA binding|bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity|transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding|transcription factor activity|sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity https://github.com/geneontology/go-ontology/issues/16534|https://github.com/geneontology/go-ontology/issues/15704|https://github.com/geneontology/go-ontology/issues/20253 Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions. krc 2010-10-21T04:37:54Z GO:0001130|GO:0001204|GO:0001199|GO:0001071|GO:0000130|GO:0001131|GO:0001151 molecular_function owl:Class
GO:0014005 biolink:NamedThing microglia development The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti microglial cell development biological_process owl:Class
GO:0047606 biolink:NamedThing hydroxynitrilase activity Catalysis of the reaction: a hydroxynitrile = cyanide + an aldehyde or ketone. got7fsn_ti acetone-cyanohydrin acetone-lyase activity|2-hydroxyisobutyronitrile acetone-lyase (cyanide-forming)|alpha-hydroxynitrile lyase activity|oxynitrilase activity|(S)-acetone-cyanohydrin lyase activity|acetone-cyanohydrin lyase activity|hydroxynitrile lyase activity|2-hydroxyisobutyronitrile acetone-lyase activity|acetone-cyanhydrin lyase activity|acetone-cyanohydrin acetone-lyase (cyanide-forming) GO:0046991 MetaCyc:ACETONE-CYANHYDRIN-LYASE-RXN|EC:4.1.2.47 molecular_function owl:Class
GO:0010280 biolink:NamedThing UDP-L-rhamnose synthase activity Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O. got7fsn_ti UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity MetaCyc:RXN-5482 molecular_function owl:Class
GO:2001066 biolink:NamedThing amylopectin binding Binding to amylopectin. got7fsn_ti jl 2011-09-14T11:46:37Z molecular_function owl:Class
GO:0003919 biolink:NamedThing FMN adenylyltransferase activity Catalysis of the reaction: ATP + FMN = diphosphate + FAD. got7fsn_ti FAD synthetase activity|ATP:FMN adenylyltransferase activity|riboflavin mononucleotide adenylyltransferase activity|adenosine triphosphate-riboflavin mononucleotide transadenylase activity|FAD diphosphorylase activity|adenosine triphosphate-riboflavine mononucleotide transadenylase activity|riboflavin adenine dinucleotide pyrophosphorylase activity|FAD pyrophosphorylase activity|flavin adenine dinucleotide synthetase activity|riboflavine adenine dinucleotide adenylyltransferase activity RHEA:17237|KEGG_REACTION:R00161|Reactome:R-HSA-196929|MetaCyc:FADSYN-RXN|EC:2.7.7.2 molecular_function owl:Class
GO:0140036 biolink:NamedThing ubiquitin-dependent protein binding Binding to a protein upon ubiquitination of the target protein. got7fsn_ti This term should only be used when the binding is shown to require ubiquitination of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of ubiquitination. It may be that the ubiquitination causes a conformational change that allows binding of the protein to another region; this type of ubiquitination-dependent protein binding is valid for annotation to this term. pg 2017-05-18T06:29:14Z molecular_function owl:Class
GO:0020025 biolink:NamedThing subpellicular microtubule Singlet microtubule that lie underneath the inner membrane pellicle complex and emanate from the basal ring of the conoid. got7fsn_ti cellular_component owl:Class
GO:0002096 biolink:NamedThing polkadots A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals. got7fsn_ti Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. cellular_component owl:Class
GO:0018118 biolink:NamedThing peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide. got7fsn_ti peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine|peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine RESID:AA0229 biological_process owl:Class
GO:0070016 biolink:NamedThing armadillo repeat domain binding Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signalling and cytoskeletal regulation. got7fsn_ti armadillo repeat binding|Arm repeat domain binding|armadillo domain binding molecular_function owl:Class
GO:0030165 biolink:NamedThing PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. got7fsn_ti DHR-domain binding|GLGF-domain binding molecular_function owl:Class
GO:0021813 biolink:NamedThing cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex. got7fsn_ti cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:1990358 biolink:NamedThing xylanosome A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose. got7fsn_ti xylanolytic complex tt 2014-04-05T18:08:54Z cellular_component owl:Class
GO:0019416 biolink:NamedThing polythionate oxidation The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor. got7fsn_ti MetaCyc:THIOSULFOX-PWY biological_process owl:Class
GO:0032426 biolink:NamedThing stereocilium tip A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation. got7fsn_ti cellular_component owl:Class
GO:0032051 biolink:NamedThing clathrin light chain binding Binding to a clathrin light chain. got7fsn_ti molecular_function owl:Class
GO:0008687 biolink:NamedThing 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+). got7fsn_ti 3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)|3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity|homoprotocatechuate 2,3-dioxygenase activity|HPC dioxygenase activity UM-BBD_reactionID:r0364|KEGG_REACTION:R03303|RHEA:15633|MetaCyc:1.13.11.15-RXN|EC:1.13.11.15 molecular_function owl:Class
GO:0085044 biolink:NamedThing disassembly by symbiont of host cuticle The process in which a symbiont organism effects a breakdown of the host organism cuticle. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti catabolism of host cuticle|degradation of host cuticle jl 2010-07-27T01:08:15Z biological_process owl:Class
GO:0030451 biolink:NamedThing regulation of complement activation, alternative pathway Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation. got7fsn_ti regulation of complement cascade, alternative pathway biological_process owl:Class
GO:0018862 biolink:NamedThing phenylphosphate carboxylase activity Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate. got7fsn_ti UM-BBD_reactionID:r0157|EC:6.4.1.-|MetaCyc:PHENYLPCARB-RXN molecular_function owl:Class
GO:0033786 biolink:NamedThing heptose-1-phosphate adenylyltransferase activity Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose. got7fsn_ti D-beta-D-heptose 1-phosphate adenylyltransferase activity|heptose 1-phosphate adenyltransferase activity RHEA:27465|MetaCyc:RXN0-4342 molecular_function owl:Class
GO:0031800 biolink:NamedThing type 3 metabotropic glutamate receptor binding Binding to a type 3 metabotropic glutamate receptor. got7fsn_ti type 3 metabotropic glutamate receptor ligand molecular_function owl:Class
GO:0045794 biolink:NamedThing negative regulation of cell volume Any process that decreases cell volume. got7fsn_ti cell regulatory volume decrease|RVD biological_process owl:Class
GO:0035181 biolink:NamedThing larval burrowing behavior Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation. got7fsn_ti larval burrowing behaviour biological_process owl:Class
GO:0060509 biolink:NamedThing type I pneumocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. got7fsn_ti small alveolar cell differentiation|squamous alveolar cell differentiation|membranous pneumocyte differentiation biological_process owl:Class
GO:0036237 biolink:NamedThing acyl-glucuronidase activity Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate. got7fsn_ti acyl-glucuronide deglucuronidation activity bf 2012-05-18T04:32:25Z molecular_function owl:Class
GO:0043914 biolink:NamedThing NADPH:sulfur oxidoreductase activity Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+. got7fsn_ti NAD(P)H sulfur oxidoreductase activity|CoA-dependent NAD(P)H sulfur oxidoreductase activity|NSR|NADPH:sulphur oxidoreductase activity|coenzyme A-dependent NAD(P)H sulfur oxidoreductase activity|NAD(P)H sulphur oxidoreductase activity|NAD(P)H elemental sulfur oxidoreductase activity|NAD(P)H:sulfur oxidoreductase activity EC:1.8.1.18 molecular_function owl:Class
GO:0098978 biolink:NamedThing glutamatergic synapse A synapse that uses glutamate as a neurotransmitter. got7fsn_ti cellular_component owl:Class
GO:0030670 biolink:NamedThing phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle. got7fsn_ti phagosome membrane cellular_component owl:Class
GO:1900814 biolink:NamedThing monodictyphenone catabolic process The chemical reactions and pathways resulting in the breakdown of monodictyphenone. got7fsn_ti monodictyphenone catabolism|monodictyphenone degradation|monodictyphenone breakdown di 2012-06-04T10:11:27Z biological_process owl:Class
GO:0019896 biolink:NamedThing axonal transport of mitochondrion The directed movement of mitochondria along microtubules in nerve cell axons. got7fsn_ti axon transport of mitochondria biological_process owl:Class
GO:0098930 biolink:NamedThing axonal transport The directed movement of organelles or molecules along microtubules in axons. got7fsn_ti axoplasmic transport|axon cargo transport Wikipedia:Axoplasmic_transport biological_process owl:Class
GO:0046567 biolink:NamedThing aphidicolan-16 beta-ol synthase activity Catalysis of the reaction: 9-alpha-copalyl diphosphate + H2O = aphidicolan-16-beta-ol + diphosphate. got7fsn_ti 9-alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16-beta-ol-forming) RHEA:26213|MetaCyc:RXN-10631|EC:4.2.3.42|KEGG_REACTION:R06313 molecular_function owl:Class
GO:0009624 biolink:NamedThing response to nematode Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode. got7fsn_ti response to nematodes biological_process owl:Class
GO:0047367 biolink:NamedThing quercetin-3,3'-bissulfate 7-sulfotransferase activity Catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate. got7fsn_ti quercetin-3,3'-bissulphate 7-sulphotransferase activity|flavonol 7-sulfotransferase activity|PAPS:flavonol 3,3'/3,4'-disulfate 7-sulfotransferase activity|7-sulfotransferase activity|3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity EC:2.8.2.28|MetaCyc:2.8.2.28-RXN|RHEA:21860 molecular_function owl:Class
GO:0071800 biolink:NamedThing podosome assembly The aggregation, arrangement and bonding together of a set of components to form a podosome, an actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell. got7fsn_ti mah 2010-09-03T11:00:45Z biological_process owl:Class
GO:0047258 biolink:NamedThing sphingosine beta-galactosyltransferase activity Catalysis of the reaction: sphingosine + UDP-D-galactose = H(+) + psychosine + UDP. got7fsn_ti uridine diphosphogalactose-sphingosine beta-galactosyltransferase activity|galactosyl-sphingosine transferase activity|psychosine-UDP galactosyltransferase activity|UDPgalactose:sphingosine O-galactosyl transferase activity|UDP-galactose:sphingosine 1-beta-galactotransferase activity|psychosine-uridine diphosphate galactosyltransferase activity|UDPgalactose:sphingosine 1-beta-galactotransferase activity MetaCyc:2.4.1.23-RXN|EC:2.4.1.23|KEGG_REACTION:R01928|RHEA:19485 molecular_function owl:Class
GO:0070478 biolink:NamedThing nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. got7fsn_ti 3'-5' NMD|nuclear-transcribed mRNA catabolism, 3'-5' exonucleolytic nonsense-mediated decay|nuclear-transcribed mRNA degradation, 3'-5' exonucleolytic nonsense-mediated decay|3'-5' nonsense-mediated decay|3'-5' nonsense-mediated mRNA decay|nuclear-transcribed mRNA breakdown, 3'-5' exonucleolytic nonsense-mediated decay biological_process owl:Class
GO:0034427 biolink:NamedThing nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction. got7fsn_ti 3'-5' exonucleolytic nuclear-transcribed mRNA catabolic process biological_process owl:Class
GO:0050604 biolink:NamedThing taxadiene 5-alpha-hydroxylase activity Catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol. got7fsn_ti taxa-4,11-diene,hydrogen-donor:oxygen oxidoreductase (5alpha-hydroxylating)|taxadiene 5a-hydroxylase activity|taxadiene 5alpha-hydroxylase activity MetaCyc:1.14.99.37-RXN|KEGG_REACTION:R06306|RHEA:14049|EC:1.14.14.176 molecular_function owl:Class
GO:0052635 biolink:NamedThing C-20 gibberellin 2-beta-dioxygenase activity Catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons. got7fsn_ti C-20 gibberellin 2-beta-hydroxylase activity|C-20 GA 2-oxidase activity|C-20 gibberellin 2beta-dioxygenase activity|C-20 gibberellin 2beta-hydroxylase activity|(C-20 gibberellin-1),2-oxoglutarate:oxygen oxidoreductase (2beta-hydroxylating)|C-20 gibberellin 2-oxidase activity|C(20) gibberellin 2-oxidase activity molecular_function owl:Class
GO:0050367 biolink:NamedThing tyrosine-arginine ligase activity Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+). got7fsn_ti L-tyrosine:L-arginine ligase (AMP-forming)|kyotorphin synthase activity|kyotorphin-synthesizing enzyme activity|tyrosyl-arginine synthase activity|kyotorphin synthetase activity KEGG_REACTION:R00735|RHEA:15345|EC:6.3.2.24|MetaCyc:TYROSINE--ARGININE-LIGASE-RXN molecular_function owl:Class
GO:0035814 biolink:NamedThing negative regulation of renal sodium excretion Any process that decreases the amount of sodium excreted in urine over a unit of time. got7fsn_ti The amount of sodium excreted in urine over a unit of time can be decreased by decreasing the volume of urine produced (antidiuresis) and/or by decreasing the concentration of sodium in the urine. bf 2011-04-20T01:27:39Z biological_process owl:Class
GO:0032980 biolink:NamedThing keratinocyte activation A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines. got7fsn_ti biological_process owl:Class
GO:0000973 biolink:NamedThing posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed. got7fsn_ti krc 2009-09-10T12:28:04Z biological_process owl:Class
GO:0000972 biolink:NamedThing transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript. got7fsn_ti krc 2009-09-10T12:25:11Z biological_process owl:Class
GO:0102690 biolink:NamedThing isopentenyladenine UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + N(6)-dimethylallyladenine = H+ + 9-(alpha-D-glucosyl)-N(6)-isopentenyladenine + UDP. got7fsn_ti MetaCyc:RXN-4728 molecular_function owl:Class
GO:0043750 biolink:NamedThing phosphatidylinositol alpha-mannosyltransferase activity Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol. got7fsn_ti guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase activity|GDP mannose-phosphatidyl-myo-inositol alpha-mannosyltransferase activity|GDP mannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity|GDPmannose:1-phosphatidyl-myo-inositol alpha-D-mannosyltransferase activity|phosphatidyl-myo-inositol alpha-mannosyltransferase activity|GDP-mannose:1-phosphatidyl-1D-myo-inositol alpha-D-mannosyltransferase activity RHEA:47368|EC:2.4.1.345|MetaCyc:2.4.1.57-RXN molecular_function owl:Class
GO:0033924 biolink:NamedThing dextran 1,6-alpha-isomaltotriosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in dextrans, to remove successive isomaltotriose units from the non-reducing ends of the chains. got7fsn_ti 1,6-alpha-D-glucan isomaltotriohydrolase activity|exo-isomaltotriohydrolase activity MetaCyc:3.2.1.95-RXN|EC:3.2.1.95 molecular_function owl:Class
GO:0097159 biolink:NamedThing organic cyclic compound binding Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. got7fsn_ti pr 2011-09-23T02:31:01Z molecular_function owl:Class
GO:0002951 biolink:NamedThing leukotriene-C(4) hydrolase Catalysis of the reaction Leukotriene C(4) + H(2)O= leukotriene D(4) + L-glutamate. got7fsn_ti The mouse enzyme is specific for leukotriene C(4), while the human enzyme also has considerable activity toward glutathione and oxidized glutathione (cf. EC:3.4.19.13). PMID:9774450 cites that the mouse form of this enzyme failed to measure activity towards glutathione. molecular_function owl:Class
GO:0060202 biolink:NamedThing clathrin-sculpted acetylcholine transport vesicle lumen The volume enclosed by the membrane of the clathrin-sculpted acetylcholine transport vesicle. got7fsn_ti clathrin sculpted acetylcholine constitutive secretory pathway transport vesicle lumen|clathrin sculpted acetylcholine transport vesicle lumen cellular_component owl:Class
GO:0120305 biolink:NamedThing regulation of pigmentation Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20524 krc 2021-02-09T19:37:35Z biological_process owl:Class
GO:0031889 biolink:NamedThing urotensin receptor binding Binding to a urotensin receptor. got7fsn_ti urotensin receptor ligand molecular_function owl:Class
GO:0043642 biolink:NamedThing novobiocin biosynthetic process The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase. got7fsn_ti Wikipedia:Novobiocin biological_process owl:Class
GO:0099524 biolink:NamedThing postsynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the postsynapse. got7fsn_ti cellular_component owl:Class
GO:0004737 biolink:NamedThing pyruvate decarboxylase activity Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2. got7fsn_ti alpha-carboxylase activity|2-oxo-acid carboxy-lyase activity|pyruvic decarboxylase activity|2-oxo-acid carboxy-lyase (aldehyde-forming)|alpha-ketoacid carboxylase activity MetaCyc:PYRUVATE-DECARBOXYLASE-RXN|RHEA:11628|EC:4.1.1.1 molecular_function owl:Class
GO:0047997 biolink:NamedThing hydroxypyruvate decarboxylase activity Catalysis of the reaction: 3-hydroxypyruvate + H(+) = CO(2) + glycolaldehyde. got7fsn_ti hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)|hydroxypyruvate carboxy-lyase activity KEGG_REACTION:R01393|MetaCyc:HYDROXYPYRUVATE-DECARBOXYLASE-RXN|RHEA:20561|EC:4.1.1.40 molecular_function owl:Class
GO:0010402 biolink:NamedThing pectic arabinan metabolic process The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I. got7fsn_ti pectic arabinan metabolism biological_process owl:Class
GO:0047515 biolink:NamedThing 1,3-beta-oligoglucan phosphorylase activity Catalysis of the reaction: [oligomeric (1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate. got7fsn_ti beta-1,3-oligoglucan phosphorylase activity|beta-1,3-oligoglucan:orthophosphate glucosyltransferase II activity|1,3-beta-D-oligoglucan:phosphate alpha-D-glucosyltransferase activity EC:2.4.1.30|MetaCyc:13-BETA-OLIGOGLUCAN-PHOSPHORYLASE-RXN|RHEA:16041 molecular_function owl:Class
GO:0071621 biolink:NamedThing granulocyte chemotaxis The movement of a granulocyte in response to an external stimulus. got7fsn_ti mah 2010-02-09T04:08:17Z biological_process owl:Class
GO:0070090 biolink:NamedThing metaphase plate The intracellular plane, located halfway between the poles of the spindle, where chromosomes align during metaphase of mitotic or meiotic nuclear division. got7fsn_ti cellular_component owl:Class
GO:0039615 biolink:NamedThing T=1 icosahedral viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres. got7fsn_ti bf 2012-07-18T01:46:17Z VZ:1057 cellular_component owl:Class
GO:0047222 biolink:NamedThing mannotetraose 2-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose + UDP-N-acetyl-D-glucosamine = 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose + UDP. got7fsn_ti uridine diphosphoacetylglucosamine mannoside alpha1->2-alphacetylglucosaminyltransferase activity|alpha-N-acetylglucosaminyltransferase activity|UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase activity MetaCyc:2.4.1.138-RXN|RHEA:13705|EC:2.4.1.138 molecular_function owl:Class
GO:0047693 biolink:NamedThing ATP diphosphatase activity Catalysis of the reaction: ATP + H2O = AMP + diphosphate. got7fsn_ti ATP diphosphohydrolase|ATP diphosphohydrolase (diphosphate-forming)|ATP pyrophosphatase activity|adenosine triphosphate pyrophosphatase activity EC:3.6.1.8|MetaCyc:ATP-PYROPHOSPHATASE-RXN|RHEA:14245 molecular_function owl:Class
GO:0047303 biolink:NamedThing glycine-oxaloacetate transaminase activity Catalysis of the reaction: glycine + oxaloacetate = L-aspartate + glyoxylate. got7fsn_ti glycine-oxaloacetate aminotransferase activity|glycine-oxalacetate aminotransferase activity|glycine:oxaloacetate aminotransferase activity|glycine--oxaloacetate aminotransferase activity EC:2.6.1.35|KEGG_REACTION:R00373|MetaCyc:2.6.1.35-RXN|RHEA:17141 molecular_function owl:Class
GO:0038022 biolink:NamedThing G protein-coupled olfactory receptor activity Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti G-protein coupled olfactory receptor activity|G-protein coupled odorant receptor activity|olfactory receptor activity, G-protein coupled|odorant receptor activity, G-protein coupled bf 2011-07-01T11:23:51Z molecular_function owl:Class
GO:0071101 biolink:NamedThing alpha4-beta1 integrin-JAM2 complex A protein complex that consists of an alpha4-beta1 integrin complex bound to the cell adhesion molecule JAM2. got7fsn_ti ITGA4-ITGB1-JAM2 complex mah 2009-11-06T04:52:59Z cellular_component owl:Class
GO:0038066 biolink:NamedThing p38MAPK cascade An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. got7fsn_ti p38 MAPK cascade|p38 cascade bf 2012-01-25T11:51:24Z biological_process owl:Class
GO:0071980 biolink:NamedThing cell surface adhesin-mediated gliding motility Cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins. got7fsn_ti mah 2010-10-21T03:03:44Z biological_process owl:Class
GO:0102996 biolink:NamedThing beta,beta digalactosyldiacylglycerol galactosyltransferase activity Catalysis of the reaction: a 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + a beta,beta digalactosyldiacylglycerol <=> a trigalactosyldiacylglycerol + a 1,2-diacyl-sn-glycerol. got7fsn_ti MetaCyc:RXN-9721|EC:2.4.1.184 molecular_function owl:Class
GO:0047165 biolink:NamedThing flavonol-3-O-beta-glucoside O-malonyltransferase activity Catalysis of the reaction: flavonol 3-O-beta-D-glucoside + malonyl-CoA = malonyl-flavonol 3-O-beta-D-glucoside + CoA. got7fsn_ti MAT-3|malonyl-coenzyme A:flavonol-3-O-glucoside malonyltransferase activity|flavonol 3-O-glucoside malonyltransferase activity|malonyl-CoA:flavonol-3-O-beta-D-glucoside 6''-O-malonyltransferase activity RHEA:20085|EC:2.3.1.116|MetaCyc:2.3.1.116-RXN molecular_function owl:Class
GO:0035177 biolink:NamedThing larval foraging behavior The movement of a larva through a feeding substrate whilst feeding on food. got7fsn_ti larval foraging behaviour biological_process owl:Class
GO:0071514 biolink:NamedThing genetic imprinting Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. got7fsn_ti DNA imprinting mah 2010-01-06T11:56:31Z biological_process owl:Class
GO:0003937 biolink:NamedThing IMP cyclohydrolase activity Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. got7fsn_ti IMP 1,2-hydrolase (decyclizing)|inosinate cyclohydrolase activity|IMP synthetase activity|inosinicase activity EC:3.5.4.10|RHEA:18445|Reactome:R-HSA-73797|MetaCyc:IMPCYCLOHYDROLASE-RXN molecular_function owl:Class
GO:0102345 biolink:NamedThing 3-hydroxy-lignoceroyl-CoA dehydratase activity Catalysis of the reaction: (R)-3-hydroxylignoceroyl-CoA(4-) <=> trans-2-tetracosenoyl-CoA + H2O. got7fsn_ti MetaCyc:RXN-13304|EC:4.2.1.134 molecular_function owl:Class
GO:0046031 biolink:NamedThing ADP metabolic process The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate. got7fsn_ti ADP metabolism biological_process owl:Class
GO:0046202 biolink:NamedThing cyanide biosynthetic process The chemical reactions and pathways resulting in the formation of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. got7fsn_ti cyanide biosynthesis|cyanide anabolism|cyanide synthesis|cyanide formation biological_process owl:Class
GO:0051876 biolink:NamedThing pigment granule dispersal The directed movement of pigment granules within a cell towards the cell periphery. got7fsn_ti biological_process owl:Class
GO:0047970 biolink:NamedThing guanidinoacetase activity Catalysis of the reaction: guanidinoacetate + H(2)O = glycine + urea. got7fsn_ti glycocyaminase activity|guanidinoacetate amidinohydrolase activity MetaCyc:GUANIDINOACETASE-RXN|KEGG_REACTION:R00775|RHEA:23268|EC:3.5.3.2 molecular_function owl:Class
GO:0047504 biolink:NamedThing (-)-menthol dehydrogenase activity Catalysis of the reaction: (-)-menthol + NADP(+) = (2S,5R)-menthone + H(+) + NADPH. got7fsn_ti (-)-menthol:NADP+ oxidoreductase activity|monoterpenoid dehydrogenase activity RHEA:13917|EC:1.1.1.207|KEGG_REACTION:R02177|MetaCyc:--MENTHOL-DEHYDROGENASE-RXN|UM-BBD_reactionID:r1182 molecular_function owl:Class
GO:0045849 biolink:NamedThing negative regulation of nurse cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of nurse cell apoptotic process. got7fsn_ti down-regulation of nurse cell apoptosis|down regulation of nurse cell apoptosis|inhibition of nurse cell apoptosis|downregulation of nurse cell apoptosis|negative regulation of nurse cell apoptosis biological_process owl:Class
GO:0047652 biolink:NamedThing allantoate deiminase activity Catalysis of the reaction: allantoate + H2O + H+ = CO2 + NH3 + ureidoglycine. got7fsn_ti allantoate amidinohydrolase (decarboxylating)|allantoate amidohydrolase activity MetaCyc:ALLANTOATE-DEIMINASE-RXN|EC:3.5.3.9|RHEA:27485 molecular_function owl:Class
GO:0097694 biolink:NamedThing establishment of RNA localization to telomere The directed movement of RNA to a specific location in the telomeric region of a chromosome. got7fsn_ti establishment of RNA localisation to telomere pr 2015-12-22T09:33:43Z biological_process owl:Class
GO:0016322 biolink:NamedThing neuron remodeling The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development. got7fsn_ti axon pruning|neuronal remodeling biological_process owl:Class
GO:0070462 biolink:NamedThing plus-end specific microtubule depolymerization The removal of tubulin heterodimers from the plus end of a microtubule. got7fsn_ti biological_process owl:Class
GO:0106006 biolink:NamedThing cytoskeletal protein-membrane anchor activity The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a plasma membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific cortical membrane location. got7fsn_ti BAR domain adaptor|cytoskeletal protein-membrane adaptor activity|cytoskeletal protein membrane tether activity|microtubule cortical anchor activity|cytoskeletal protein membrane anchor activity|membrane-cytoskeletal protein tether activity|F-BAR domain adaptor|cytoskeletal protein membrane adaptor|membrane-cytoskeletal protein anchor activity https://github.com/geneontology/go-ontology/issues/18281|https://github.com/geneontology/go-ontology/issues/17668|https://github.com/geneontology/go-ontology/issues/19119 hjd 2017-04-14T15:11:13Z GO:0140362 molecular_function owl:Class
GO:1990339 biolink:NamedThing laminin-522 complex A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains. got7fsn_ti laminin-522 bhm 2014-03-20T23:41:32Z cellular_component owl:Class
GO:0033719 biolink:NamedThing 2-oxo-acid reductase activity Catalysis of the reaction: a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor. got7fsn_ti 2-oxoacid reductase activity|(2R)-hydroxy-carboxylate:acceptor oxidoreductase activity|HVOR|(2R)-hydroxycarboxylate-viologen-oxidoreductase activity EC:1.1.99.30|MetaCyc:1.1.99.30-RXN|RHEA:23664 molecular_function owl:Class
GO:0035979 biolink:NamedThing histone kinase activity (H2A-S139 specific) Catalysis of the transfer of a phosphate group to the serine-139 residue of the C-terminal tail of histone H2A. got7fsn_ti histone kinase activity (H2A.x-S139 specific) Residue 1 of histone H2A is taken as the first residue following removal of the initiating Methionine (Met). bf 2011-08-22T01:13:34Z molecular_function owl:Class
GO:0140586 biolink:NamedThing promoter-terminator loop anchoring activity Bridging together a cis-regulatory element and a terminator DNA sequences on the chromatin, holding two loop anchors together, maintaining a chromatin loop. got7fsn_ti terminator-promoter loop anchoring activity https://github.com/geneontology/go-ontology/issues/20204 Note that GO does not separately defines enhancers, since this concept is very close to that of cis-regulatory elements. However the literature refers to 'promoter-enhancer loops' to describe loops that bring together cis-regulatory elements. Note also that while SO defines 'promoter' as the core promoter, here it is used to mean a cis-regulatory element. pg 2021-02-04T14:51:44Z molecular_function owl:Class
GO:0080057 biolink:NamedThing sepal vascular tissue pattern formation Vascular tissue pattern formation as it occurs in the sepal of vascular plants. got7fsn_ti dhl 2009-04-13T02:26:19Z biological_process owl:Class
GO:0072672 biolink:NamedThing neutrophil extravasation The migration of a neutrophil from the blood vessels into the surrounding tissue. got7fsn_ti mah 2011-02-21T03:03:52Z biological_process owl:Class
GO:0048763 biolink:NamedThing calcium-induced calcium release activity Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration. got7fsn_ti molecular_function owl:Class
GO:0042278 biolink:NamedThing purine nucleoside metabolic process The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). got7fsn_ti purine metabolic process|purine metabolism|purine nucleoside metabolism biological_process owl:Class
GO:0060109 biolink:NamedThing medial layer of collagen and cuticulin-based cuticle extracellular matrix The fluid-filled cuticle layer that lies between the cortical and basal layers and is characterized by the presence of regularly spaced columnar struts that lie on either side of the annular furrows and link the two surrounding layers. In C. elegans, a defined medial layer is found only in adult animals. got7fsn_ti medial layer struts cellular_component owl:Class
GO:0102097 biolink:NamedThing (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + O2 + NADPH + H+ <=> 3-dehydro-6-deoxoteasterone + NADP + H2O. got7fsn_ti EC:1.14.14.147|RHEA:27325|MetaCyc:RXN-11101 molecular_function owl:Class
GO:0016817 biolink:NamedThing hydrolase activity, acting on acid anhydrides Catalysis of the hydrolysis of any acid anhydride. got7fsn_ti hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement EC:3.6.-.- molecular_function owl:Class
GO:0047525 biolink:NamedThing 2'-hydroxydaidzein reductase activity Catalysis of the reaction: 2'-hydroxydihydrodaidzein + NADP+ = 2'-hydroxydaidzein + NADPH + H+. got7fsn_ti 2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity|2'-hydroxy-2,3-dihydrodaidzein:NADP+ 2'-oxidoreductase activity|HDR activity|2'-hydroxydihydrodaidzein:NADP+ 2'-oxidoreductase activity|NADPH:2'-hydroxydaidzein oxidoreductase activity EC:1.3.1.51|MetaCyc:RXN-4502|RHEA:17145 molecular_function owl:Class
GO:0030156 biolink:NamedThing benzodiazepine receptor binding Binding to a peripheral benzodiazepine receptor (PBR). got7fsn_ti benzodiazepine receptor ligand|diazepam binding inhibitor activity molecular_function owl:Class
GO:0047803 biolink:NamedThing cysteine lyase activity Catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide. got7fsn_ti L-cysteine hydrogen-sulfide-lyase (adding sulfite)|L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)|cysteine (sulfite) lyase activity EC:4.4.1.10|RHEA:20916|MetaCyc:CYSTEINE-LYASE-RXN molecular_function owl:Class
GO:0102121 biolink:NamedThing ceramidase activity Catalysis of the reaction: H2O + a ceramide = a sphingoid base + a fatty acid. got7fsn_ti EC:3.5.1.23|MetaCyc:RXN-11375 molecular_function owl:Class
GO:0047294 biolink:NamedThing phosphoglycerol geranylgeranyltransferase activity Catalysis of the reaction: sn-glycerol 1-phosphate + all-trans-geranylgeranyl diphosphate = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + diphosphate. got7fsn_ti geranylgeranyl-transferase activity|geranylgeranyl diphosphate:sn-glyceryl phosphate geranylgeranyltransferase activity|glycerol phosphate geranylgeranyltransferase activity MetaCyc:2.5.1.41-RXN|EC:2.5.1.41|RHEA:23404|KEGG_REACTION:R04158 molecular_function owl:Class
GO:0031997 biolink:NamedThing N-terminal myristoylation domain binding Binding to the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin. got7fsn_ti molecular_function owl:Class
GO:0039646 biolink:NamedThing modulation by virus of host G0/G1 transition checkpoint Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint. got7fsn_ti G0/G1 host cell cycle checkpoint dysregulation by virus bf 2012-10-09T15:11:22Z VZ:881 biological_process owl:Class
GO:0045741 biolink:NamedThing positive regulation of epidermal growth factor-activated receptor activity Any process that activates or increases the frequency, rate or extent of EGF-activated receptor activity. got7fsn_ti positive regulation of EGFR activity|up-regulation of epidermal growth factor receptor activity|stimulation of epidermal growth factor receptor activity|upregulation of epidermal growth factor receptor activity|activation of epidermal growth factor receptor activity|positive regulation of epidermal growth factor receptor activity|positive regulation of EGF receptor activity|up regulation of epidermal growth factor receptor activity biological_process owl:Class
GO:0045742 biolink:NamedThing positive regulation of epidermal growth factor receptor signaling pathway Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. got7fsn_ti positive regulation of EGF receptor signaling pathway|positive regulation of EGF receptor signalling pathway|activation of epidermal growth factor receptor signaling pathway|upregulation of epidermal growth factor receptor signaling pathway|up-regulation of epidermal growth factor receptor signaling pathway|positive regulation of EGFR signaling pathway|stimulation of epidermal growth factor receptor signaling pathway|up regulation of epidermal growth factor receptor signaling pathway biological_process owl:Class
GO:0008293 biolink:NamedThing torso signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti torso signalling pathway biological_process owl:Class
GO:0102847 biolink:NamedThing 1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:3-2-16:2-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:3-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8309 molecular_function owl:Class
GO:0097464 biolink:NamedThing thorny excrescence Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads. got7fsn_ti pr 2012-12-21T08:00:13Z NIF_Subcellular:nlx_467 cellular_component owl:Class
GO:0004449 biolink:NamedThing isocitrate dehydrogenase (NAD+) activity Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. got7fsn_ti nicotinamide adenine dinucleotide isocitrate dehydrogenase activity|isocitrate:NAD+ oxidoreductase (decarboxylating)|isocitrate dehydrogenase (NAD) activity|NAD isocitric dehydrogenase activity|NAD-specific isocitrate dehydrogenase activity|NAD dependent isocitrate dehydrogenase activity|NAD isocitrate dehydrogenase activity|NAD-linked isocitrate dehydrogenase activity Reactome:R-HSA-70967|EC:1.1.1.41|MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN|RHEA:23632 molecular_function owl:Class
GO:0018449 biolink:NamedThing 1-phenylethanol dehydrogenase activity Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2. got7fsn_ti UM-BBD_reactionID:r0032 molecular_function owl:Class
GO:0097131 biolink:NamedThing cyclin D1-CDK6 complex A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:55:26Z cellular_component owl:Class
GO:0033922 biolink:NamedThing peptidoglycan beta-N-acetylmuramidase activity Catalysis of the hydrolysis of terminal, non-reducing N-acetylmuramic residues. got7fsn_ti exo-beta-N-acetylmuramidase activity|exo-beta-acetylmuramidase activity|peptidoglycan beta-N-acetylmuramoylexohydrolase activity|beta-2-acetamido-3-O-(D-1-carboxyethyl)-2-deoxy-D-glucoside acetamidodeoxyglucohydrolase activity MetaCyc:3.2.1.92-RXN|EC:3.2.1.92 molecular_function owl:Class
GO:0061030 biolink:NamedThing epithelial cell differentiation involved in mammary gland alveolus development The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland alveolus. got7fsn_ti dph 2010-02-09T09:43:00Z biological_process owl:Class
GO:0000011 biolink:NamedThing vacuole inheritance The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton. got7fsn_ti biological_process owl:Class
GO:0031816 biolink:NamedThing P2Y6 nucleotide receptor binding Binding to a P2Y6 nucleotide receptor. got7fsn_ti P2Y6 nucleotide receptor ligand molecular_function owl:Class
GO:0061686 biolink:NamedThing hercynylcysteine sulfoxide synthase activity Catalysis of the reaction: L-cysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine (hercynine) + O2 <=> hercynylcysteine sulfoxide + H2O. got7fsn_ti hercynylcysteine sulfoxide synthase|hercynylcysteine S-oxide synthase https://github.com/geneontology/go-ontology/issues/11163 dph 2015-03-06T15:08:51Z EC:1.14.99.51|RHEA:42704 molecular_function owl:Class
GO:0009724 biolink:NamedThing detection of abscisic acid stimulus The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of abscisic acid stimulus biological_process owl:Class
GO:0097645 biolink:NamedThing amylin binding Binding to amylin. got7fsn_ti pr 2014-09-08T20:53:03Z molecular_function owl:Class
GO:0018875 biolink:NamedThing anaerobic benzoate metabolic process The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen. got7fsn_ti anaerobic benzoate metabolism MetaCyc:CENTBENZCOA-PWY|UM-BBD_pathwayID:benz biological_process owl:Class
GO:0043821 biolink:NamedThing propionyl-CoA:succinate CoA-transferase activity Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate. got7fsn_ti propionyl-CoA succinate CoA-transferase activity|propionyl-CoA:succinate CoA transferase activity RHEA:28010|MetaCyc:RXN0-268 molecular_function owl:Class
GO:0044565 biolink:NamedThing dendritic cell proliferation The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. got7fsn_ti jl 2012-04-05T04:31:39Z biological_process owl:Class
GO:0001777 biolink:NamedThing T cell homeostatic proliferation The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus. got7fsn_ti T-cell homeostatic proliferation|resting T cell proliferation|T-lymphocyte homeostatic proliferation|resting T-cell proliferation|T lymphocyte homeostatic proliferation biological_process owl:Class
GO:0004498 biolink:NamedThing calcidiol 1-monooxygenase activity Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+). got7fsn_ti 25-hydroxy D3-1alpha-hydroxylase activity|25-hydroxy vitamin D3 1-alpha-hydroxylase activity|1-hydroxylase-25-hydroxyvitamin D3 activity|calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)|cytochrome P450 CYP27B|25-hydroxyvitamin D3 1alpha-hydroxylase activity|25-hydroxycholecalciferol 1alpha-hydroxylase activity|25-hydroxycholecalciferol-1-hydroxylase activity|25-hydroxyvitamin D-1 alpha hydroxylase activity|25-hydroxycholecalciferol 1-hydroxylase activity|25-OHD-1 alpha-hydroxylase activity|25-hydroxycholecalciferol 1-monooxygenase activity EC:1.14.15.18|RHEA:20573|Reactome:R-HSA-5602186|KEGG_REACTION:R03610|MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN|Reactome:R-HSA-209868 molecular_function owl:Class
GO:0004979 biolink:NamedThing beta-endorphin receptor activity Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). got7fsn_ti mu-opioid receptor activity molecular_function owl:Class
GO:0034539 biolink:NamedThing 3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity Catalysis of the reaction: 3,3',5,5'-tetrabromobisphenol A + 2 H+ + 2 e- = 3,3',5-tribromobisphenol A + HBr. got7fsn_ti EC:1.97.1.-|UM-BBD_reactionID:r0821 molecular_function owl:Class
GO:0018322 biolink:NamedThing protein tyrosinylation The addition of a tyrosine molecule to a protein amino acid. got7fsn_ti protein amino acid tyrosinylation biological_process owl:Class
GO:0045735 biolink:NamedThing nutrient reservoir activity Functions in the storage of nutritious substrates. got7fsn_ti storage protein of fat body|storage protein|yolk protein Note that this term can be used in place of the obsolete terms 'storage protein ; GO:0005187' and 'storage protein of fat body (sensu Insecta) ; GO:0008041'. molecular_function owl:Class
GO:0015820 biolink:NamedThing leucine transport The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-leucine transport biological_process owl:Class
GO:0030752 biolink:NamedThing 5-hydroxyfuranocoumarin 5-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin. got7fsn_ti furanocoumarin 5-O-methyltransferase activity|bergaptol methyltransferase activity|bergaptol 5-O-methyltransferase activity|furanocoumarin 5-methyltransferase activity|bergaptol O-methyltransferase activity|S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity|S-adenosyl-L-methionine:bergaptolO-methyltransferase activity|S-adenosyl-L-methionine:bergaptol O-methyltransferase activity|S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity|BMT activity GO:0030764 MetaCyc:2.1.1.69-RXN|RHEA:11808|EC:2.1.1.69 molecular_function owl:Class
GO:0036050 biolink:NamedThing peptidyl-lysine succinylation The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine. got7fsn_ti bf 2011-12-12T09:51:27Z RESID:AA0545 biological_process owl:Class
GO:0062144 biolink:NamedThing L-propargylglycine synthase activity Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H(+) + L-propargylglycine. got7fsn_ti dph 2019-09-02T16:48:52Z RHEA:59892 molecular_function owl:Class
GO:0014728 biolink:NamedThing regulation of the force of skeletal muscle contraction Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges. got7fsn_ti biological_process owl:Class
GO:0031217 biolink:NamedThing glucan 1,4-beta-glucosidase activity Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units. got7fsn_ti exo-1,4-beta-D-glucosidase activity|exo-beta-1,4-glucosidase activity|exo-1,4-beta-glucosidase activity|1,4-beta-D-glucan glucohydrolase activity|beta-1,4-beta-glucanase activity|exo-beta-1,4-glucanase activity|exo-1,4-beta-glucanase activity|beta-1,4-glucanase activity|exocellulase activity MetaCyc:3.2.1.74-RXN|EC:3.2.1.74 molecular_function owl:Class
GO:0102881 biolink:NamedThing (+)-beta-barbatene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-barbatene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8421 molecular_function owl:Class
GO:0051264 biolink:NamedThing mono-olein transacylation activity Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol. got7fsn_ti monoolein transacylation|mono-oleoylglycerol transacylase activity|acyl-CoA-independent mono-olein transacylation|monooleoylglycerol O-acyltransferase activity|MOG transacylation|mono-oleoylglycerol O-acyltransferase activity|monooleoylglycerol transacylase activity molecular_function owl:Class
GO:0050312 biolink:NamedThing sulfoacetaldehyde lyase activity Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite. got7fsn_ti sulphoacetaldehyde lyase activity Note that EC:4.4.1.12 was deleted from EC as the reaction is performed by sulfoacetaldehyde acetyltransferase (EC:2.3.3.15). EC:4.4.1.- molecular_function owl:Class
GO:0052596 biolink:NamedThing phenethylamine:oxygen oxidoreductase (deaminating) activity Catalysis of the reaction: phenylethylamine + O2 + H2O = phenylacetaldehyde + NH3 + hydrogen peroxide + H+. got7fsn_ti KEGG_REACTION:R02613|MetaCyc:AMINEPHEN-RXN|RHEA:25265|EC:1.4.3.21 molecular_function owl:Class
GO:0031132 biolink:NamedThing serine 3-dehydrogenase activity Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH. got7fsn_ti L-serine:NADP+ 3-oxidoreductase activity EC:1.1.1.276|KEGG_REACTION:R06126|Wikipedia:Serine_3-dehydrogenase|RHEA:21596|MetaCyc:RXN0-2201 molecular_function owl:Class
GO:0150091 biolink:NamedThing multiple spine synapse organization, multiple dendrites A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites. got7fsn_ti bc 2018-08-08T15:05:29Z biological_process owl:Class
GO:0050556 biolink:NamedThing deacetylisoipecoside synthase activity Catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin. got7fsn_ti deacetylisoipecoside dopamine-lyase (secologanin-forming)|deacetylisoipecoside dopamine-lyase activity EC:4.3.3.3|MetaCyc:4.3.3.3-RXN|RHEA:21756|KEGG_REACTION:R05750 molecular_function owl:Class
GO:0042370 biolink:NamedThing thiamine diphosphate dephosphorylation The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. got7fsn_ti thiamin diphosphate dephosphorylation|TPP dephosphorylation biological_process owl:Class
GO:0042357 biolink:NamedThing thiamine diphosphate metabolic process The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. got7fsn_ti thiamine diphosphate metabolism|TPP metabolism|thiamin pyrophosphate metabolism|thiamine pyrophosphate metabolism|thiamin diphosphate metabolic process|thiamin pyrophosphate metabolic process|TPP metabolic process|thiamine pyrophosphate metabolic process|thiamin diphosphate metabolism biological_process owl:Class
GO:0009102 biolink:NamedThing biotin biosynthetic process The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. got7fsn_ti vitamin H biosynthesis|biotin biosynthesis|vitamin H biosynthetic process|biotin synthesis|biotin formation|vitamin B7 biosynthesis|biotin anabolism|vitamin B7 biosynthetic process MetaCyc:BIOTIN-SYNTHESIS-PWY biological_process owl:Class
GO:0102243 biolink:NamedThing ATP:geranylgeraniol phosphotransferase activity Catalysis of the reaction: (E,E)-geranylgeraniol + ATP = H+ + all-trans-geranyl-geranyl monophosphate + ADP. got7fsn_ti RHEA:61660|MetaCyc:RXN-12325|EC:2.7.1.216 molecular_function owl:Class
GO:0007141 biolink:NamedThing male meiosis I A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline. got7fsn_ti male meiosis I nuclear division biological_process owl:Class
GO:0150025 biolink:NamedThing oxidised low-density lipoprotein particle receptor activity Combining with an oxidised low-density lipoprotein particle and delivering the oxidised low-density lipoprotein particle into the cell via endocytosis. got7fsn_ti oxidised LDL receptor activity|oxidized low-density lipoprotein receptor activity|ox-LDL particle receptor activity|ox-LDL receptor activity|oxidized low-density lipoprotein particle receptor activity|oxidised low-density lipoprotein receptor activity|oxLDL particle receptor activity|oxidised LDL particle receptor activity|oxidized LDL particle receptor activity|oxLDL receptor activity|oxidized LDL receptor activity bc 2018-02-06T14:17:33Z molecular_function owl:Class
GO:1990515 biolink:NamedThing 3' transitive RNA interference An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA. got7fsn_ti jl 2014-10-09T15:31:01Z biological_process owl:Class
GO:0016738 biolink:NamedThing oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen. got7fsn_ti EC:1.19.6.- molecular_function owl:Class
GO:0072429 biolink:NamedThing response to intra-S DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling. got7fsn_ti intra-S DNA damage checkpoint effector process|response to signal involved in intra-S DNA damage checkpoint mah 2010-12-08T04:31:56Z biological_process owl:Class
GO:0035823 biolink:NamedThing short tract gene conversion A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor. got7fsn_ti bf 2011-05-04T01:05:35Z biological_process owl:Class
GO:0060239 biolink:NamedThing positive regulation of signal transduction involved in conjugation with cellular fusion Any process that increases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion. got7fsn_ti biological_process owl:Class
GO:0030759 biolink:NamedThing methylquercetagetin 6-O-methyltransferase activity Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity|6-OMT|flavonol 6-O-methyltransferase activity|flavonol 6-methyltransferase activity MetaCyc:2.1.1.84-RXN|RHEA:18717|EC:2.1.1.84|KEGG_REACTION:R04505 molecular_function owl:Class
GO:0047548 biolink:NamedThing 2-methyleneglutarate mutase activity Catalysis of the reaction: 2-methyleneglutarate = 2-methylene-3-methylsuccinate. got7fsn_ti alpha-methyleneglutarate mutase activity|2-methyleneglutarate carboxy-methylenemethylmutase activity EC:5.4.99.4|MetaCyc:2-METHYLENEGLUTARATE-MUTASE-RXN|RHEA:13793|KEGG_REACTION:R03908 molecular_function owl:Class
GO:0034822 biolink:NamedThing citronellal dehydrogenase activity Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+. got7fsn_ti UM-BBD_reactionID:r1156 molecular_function owl:Class
GO:0070304 biolink:NamedThing positive regulation of stress-activated protein kinase signaling cascade Any process that activates or increases the frequency, rate or extent of signaling via the stress-activated protein kinase signaling cascade. got7fsn_ti up regulation of stress-activated protein kinase signaling pathway|stimulation of stress-activated protein kinase signaling pathway|activation of stress-activated protein kinase signaling pathway|upregulation of stress-activated protein kinase signaling pathway|positive regulation of stress-activated protein kinase signalling pathway|positive regulation of stress-activated protein kinase signaling pathway|up-regulation of stress-activated protein kinase signaling pathway|positive regulation of SAPK signaling pathway biological_process owl:Class
GO:0061236 biolink:NamedThing mesonephric comma-shaped body morphogenesis The process in which the mesonephric comma-shaped body is generated and organized. The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros. got7fsn_ti dph 2010-08-19T03:00:21Z biological_process owl:Class
GO:0047205 biolink:NamedThing quinate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: feruloyl-CoA + quinate = O-feruloylquinate + CoA. got7fsn_ti hydroxycinnamoyl coenzyme A-quinate transferase activity|feruloyl-CoA:quinate O-(hydroxycinnamoyl)transferase activity EC:2.3.1.99|MetaCyc:2.3.1.99-RXN|RHEA:15021 molecular_function owl:Class
GO:0019496 biolink:NamedThing serine-isocitrate lyase pathway A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide. got7fsn_ti biological_process owl:Class
GO:0102851 biolink:NamedThing 1-18:2-2-16:0-phosphatidylglycerol desaturase activity Catalysis of the reaction: 1-18:2-2-16:0-phosphatidylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-trans-16:1-phosphatidylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8318|EC:1.14.19.43 molecular_function owl:Class
GO:0070075 biolink:NamedThing tear secretion The regulated release of the aqueous layer of the tear film from the lacrimal glands. Tears are the liquid product of a process of lacrimation to clean and lubricate the eyes. Tear fluid contains water, mucin, lipids, lysozyme, lactoferrin, lipocalin, lacritin, immunoglobulins, glucose, urea, sodium, and potassium. got7fsn_ti biological_process owl:Class
GO:0042962 biolink:NamedThing acridine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out). got7fsn_ti acridine efflux pump activity|acridine:hydrogen antiporter activity molecular_function owl:Class
GO:0120312 biolink:NamedThing ciliary basal body segregation The process in which the duplicated basal bodies migrate in pairs to the mitotic poles of the nucleus and results in equal distribution in the daughter cells. Ciliary basal body segregation ensures inheritance of the duplicated mitochondrial DNA to the two daughter cells in the Trypanosoma parasites. got7fsn_ti microtubule basal body segregation|microtubule basal body separation|ciliary basal body separation krc 2021-03-27T04:04:14Z biological_process owl:Class
GO:0031485 biolink:NamedThing myosin XV complex A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII. got7fsn_ti cellular_component owl:Class
GO:0001795 biolink:NamedThing type IIb hypersensitivity An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors. got7fsn_ti type V hypersensitivity Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity. biological_process owl:Class
GO:0000761 biolink:NamedThing conjugant formation During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing. got7fsn_ti biological_process owl:Class
GO:0002869 biolink:NamedThing positive regulation of B cell deletion Any process that activates or increases the frequency, rate, or extent of B cell deletion. got7fsn_ti up-regulation of B cell deletion|positive regulation of B lymphocyte deletion|up regulation of B cell deletion|positive regulation of B-lymphocyte deletion|activation of B cell deletion|stimulation of B cell deletion|positive regulation of B-cell deletion|upregulation of B cell deletion biological_process owl:Class
GO:0080061 biolink:NamedThing indole-3-acetonitrile nitrilase activity Catalysis of the reaction: indole-3-acetonitrile + 2 H2O = indole-3-acetic acid + NH3. got7fsn_ti dhl 2009-04-13T03:30:42Z MetaCyc:RXN-1404|EC:3.5.5.1|RHEA:45776 molecular_function owl:Class
GO:0033354 biolink:NamedThing chlorophyll cycle A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates. got7fsn_ti MetaCyc:PWY-5068 biological_process owl:Class
GO:0015994 biolink:NamedThing chlorophyll metabolic process The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. got7fsn_ti chlorophyll metabolism biological_process owl:Class
GO:0047830 biolink:NamedThing D-octopine dehydrogenase activity Catalysis of the reaction: N2-(D-1-carboxyethyl)-L-arginine + NAD+ + H2O = L-arginine + pyruvate + NADH. got7fsn_ti N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)|2-N-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (L-arginine-forming)|octopine:NAD oxidoreductase activity|ODH activity|octopine dehydrogenase activity|D-octopine synthase activity MetaCyc:D-OCTOPINE-DEHYDROGENASE-RXN|RHEA:16285|EC:1.5.1.11 molecular_function owl:Class
GO:0046819 biolink:NamedThing protein secretion by the type V secretion system The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway. got7fsn_ti autotransporter system|protein secretion by the type V protein secretion system|type V protein secretion system|protein secretion by the autotransporter system biological_process owl:Class
GO:0031245 biolink:NamedThing extrinsic component of periplasmic side of cell outer membrane The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to periplasmic side of cell outer membrane|extrinsic to internal leaflet of cell outer membrane|extrinsic to internal side of cell outer membrane|extrinsic to internal side of outer membrane cellular_component owl:Class
GO:0039704 biolink:NamedThing viral translational shunt A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site. got7fsn_ti ribosomal shunt initiation pathway This term is intended to annotate gene products involved in the process of viral translational shunt, not viral proteins produced by this translation process. bf 2013-11-21T17:08:40Z VZ:608 biological_process owl:Class
GO:0006808 biolink:NamedThing regulation of nitrogen utilization Any process that modulates the frequency, rate or extent of nitrogen utilization. got7fsn_ti biological_process owl:Class
GO:0051898 biolink:NamedThing negative regulation of protein kinase B signaling Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. got7fsn_ti down-regulation of protein kinase B signaling cascade|negative regulation of AKT signaling cascade|negative regulation of PKB signalling cascade|inhibition of protein kinase B signaling cascade|negative regulation of PKB signaling cascade|down regulation of protein kinase B signaling cascade|negative regulation of protein kinase B signalling cascade|negative regulation of protein kinase B signaling cascade|negative regulation of AKT signalling cascade|downregulation of protein kinase B signaling cascade biological_process owl:Class
GO:0032767 biolink:NamedThing copper-dependent protein binding Binding to a protein or protein complex, in the presence of copper. got7fsn_ti molecular_function owl:Class
GO:0047055 biolink:NamedThing salutaridine synthase activity Catalysis of the reaction: (R)-reticuline + [reduced NADPH--hemoprotein reductase] + O2 -> salutaridine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. got7fsn_ti (R)-reticuline oxidase (C-C phenol-coupling) activity https://github.com/geneontology/go-ontology/issues/21133 MetaCyc:1.1.3.35-RXN|EC:1.14.19.67|RHEA:17713|KEGG_REACTION:R04696 molecular_function owl:Class
GO:0090221 biolink:NamedThing mitotic spindle-templated microtubule nucleation The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle. got7fsn_ti tb 2010-01-13T10:42:37Z biological_process owl:Class
GO:0098516 biolink:NamedThing detection of high humidity The series of events in which high humidity is detected and converted into a molecular signal. got7fsn_ti dos 2013-09-25T14:26:47Z biological_process owl:Class
GO:0016428 biolink:NamedThing tRNA (cytosine-5-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine. got7fsn_ti transfer RNA cytosine 5-methyltransferase activity|transfer ribonucleate cytosine 5-methyltransferase activity|S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity Reactome:R-HSA-8932765|Reactome:R-HSA-6782388|Reactome:R-HSA-6785409|Reactome:R-HSA-6782419|Reactome:R-HSA-6785438 molecular_function owl:Class
GO:0051392 biolink:NamedThing tRNA N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA. got7fsn_ti tRNA cytidine N-acetyltransferase activity molecular_function owl:Class
GO:0017161 biolink:NamedThing inositol-1,3,4-trisphosphate 4-phosphatase activity Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate. got7fsn_ti Reactome:R-HSA-1855180|RHEA:43392 molecular_function owl:Class
GO:0031265 biolink:NamedThing CD95 death-inducing signaling complex A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor. got7fsn_ti CD95 death-inducing signalling complex|Fas death-inducing signaling complex|CD95 DISC cellular_component owl:Class
GO:0010308 biolink:NamedThing acireductone dioxygenase (Ni2+-requiring) activity Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate. got7fsn_ti E-2 activity|ARD activity|acireductone dioxygenase activity|2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity|1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming) RHEA:14161|KEGG_REACTION:R07363|EC:1.13.11.53|MetaCyc:R146-RXN molecular_function owl:Class
GO:0031737 biolink:NamedThing CX3C chemokine receptor binding Binding to a CX3C chemokine receptor. got7fsn_ti CX3C chemokine receptor ligand|fractalkine receptor binding molecular_function owl:Class
GO:0018906 biolink:NamedThing methyl tert-butyl ether metabolic process The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent. got7fsn_ti methyl tert-butyl ether metabolism UM-BBD_pathwayID:mtb biological_process owl:Class
GO:0090403 biolink:NamedThing oxidative stress-induced premature senescence A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals. got7fsn_ti tb 2011-01-05T02:37:57Z biological_process owl:Class
GO:0018778 biolink:NamedThing DL-2 haloacid dehalogenase activity Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate. got7fsn_ti EC:3.8.1.10|MetaCyc:RXN-9150|UM-BBD_reactionID:r0382 molecular_function owl:Class
GO:0047338 biolink:NamedThing UTP:xylose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-xylose 1-phosphate + UTP = UDP-D-xylose + diphosphate. got7fsn_ti UDP-xylose pyrophosphorylase activity|uridine diphosphoxylose pyrophosphorylase activity|xylose-1-phosphate uridylyltransferase activity|UTP:alpha-D-xylose-1-phosphate uridylyltransferase activity|UTP-xylose-1-phosphate uridylyltransferase activity|xylose 1-phosphate uridylyltransferase activity|uridylyltransferase, xylose 1-phosphate EC:2.7.7.11|MetaCyc:2.7.7.11-RXN|RHEA:18389 molecular_function owl:Class
GO:0097663 biolink:NamedThing SCF-Dia2/Pof3 ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe). got7fsn_ti pr 2014-10-06T10:26:44Z cellular_component owl:Class
GO:0102596 biolink:NamedThing cytochrome P450 dependent ent-sandaracopimaradiene 3-hydroxylase activity Catalysis of the reaction: ent-sandaracopimara-8(14),15-diene + NADPH + H+ + O2 <=> ent-sandaracopimaradien-3beta-ol + NADP + H2O. got7fsn_ti MetaCyc:RXN-15379|EC:1.14.14.70|RHEA:41464 molecular_function owl:Class
GO:0018405 biolink:NamedThing protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues. got7fsn_ti protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine RESID:AA0247 biological_process owl:Class
GO:0071119 biolink:NamedThing alpha7-beta1 integrin-nicotinamide riboside kinase complex A protein complex that consists of an alpha7-beta1 integrin complex bound to nicotinamide riboside kinase 2 (also known as muscle integrin binding protein, MIBP). got7fsn_ti ITGA7-ITGB1-ITGB1BP3 complex mah 2009-11-13T02:20:44Z cellular_component owl:Class
GO:0051669 biolink:NamedThing fructan beta-fructosidase activity Catalysis of the hydrolysis of terminal, non-reducing 2,1- and 2,6-linked beta-D-fructofuranose residues in fructans. got7fsn_ti polysaccharide beta-fructofuranosidase activity|exo-beta-fructosidase activity|fructan exohydrolase activity|fructanase activity|fructan b-fructosidase activity|beta-D-fructan fructohydrolase activity|exo-beta-D-fructosidase activity EC:3.2.1.80|MetaCyc:3.2.1.80-RXN molecular_function owl:Class
GO:0061508 biolink:NamedThing CDP phosphorylation The process of introducing a phosphate group into CDP to produce a CTP. got7fsn_ti dph 2013-02-21T13:38:11Z biological_process owl:Class
GO:1900686 biolink:NamedThing regulation of gerfelin biosynthetic process Any process that modulates the frequency, rate or extent of gerfelin biosynthetic process. got7fsn_ti regulation of gerfelin biosynthesis|regulation of gerfelin formation|regulation of gerfelin synthesis|regulation of gerfelin anabolism di 2012-05-22T04:49:44Z biological_process owl:Class
GO:0090633 biolink:NamedThing keto-deoxynonulosonic acid (KDN) cytidylyltransferase activity Catalysis of the reaction: CTP + KDN = diphosphate + CMP-KDN. got7fsn_ti CMP-KDN synthetase activity|cytidine 5'-monophospho-2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid synthetase activity tb 2015-03-19T15:05:54Z molecular_function owl:Class
GO:0010859 biolink:NamedThing calcium-dependent cysteine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner. got7fsn_ti molecular_function owl:Class
GO:0036455 biolink:NamedThing iron-sulfur transferase activity Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor). got7fsn_ti Fe-S transferase activity bf 2013-11-14T11:17:37Z Reactome:R-HSA-2564828 molecular_function owl:Class
GO:0102797 biolink:NamedThing geranial:oxygen oxidoreductase activity Catalysis of the reaction: geranial + O2 + H2O = H+ + geranate + hydrogen peroxide. got7fsn_ti EC:1.2.3.1|MetaCyc:RXN-8093 molecular_function owl:Class
GO:1990780 biolink:NamedThing cytoplasmic side of dendritic spine plasma membrane The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine. got7fsn_ti sl 2015-06-23T18:35:39Z cellular_component owl:Class
GO:0004418 biolink:NamedThing hydroxymethylbilane synthase activity Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). got7fsn_ti porphobilinogen ammonia-lyase (polymerizing)|uroporphyrinogen I synthase activity|uroporphyrinogen synthase activity|uroporphyrinogen synthetase activity|pre-uroporphyrinogen synthase activity|porphobilinogen deaminase activity|uroporphyrinogen I synthetase activity|(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)|HMB-synthase activity|(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity|porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing) Note that this function was formerly EC:4.3.1.8. Reactome:R-HSA-189406|KEGG_REACTION:R00084|MetaCyc:OHMETHYLBILANESYN-RXN|RHEA:13185|EC:2.5.1.61 molecular_function owl:Class
GO:1905805 biolink:NamedThing excitatory synapse pruning The disaggregation of an excitatory synapse into its constituent components. got7fsn_ti synapse elimination|synapse clearance|synapse disassembly|synapse removal tb 2017-01-11T22:03:06Z biological_process owl:Class
GO:0102753 biolink:NamedThing chlorophyllide b:geranyl-geranyl diphosphate geranyl-geranyltransferase activity Catalysis of the reaction: H+ + chlorophyllide b(1-) + 2-trans,6-trans,10-trans-geranylgeranyl diphosphate <=> geranylgeranyl-chlorophyll b + diphosphoric acid. got7fsn_ti MetaCyc:RXN-7673 molecular_function owl:Class
GO:0016844 biolink:NamedThing strictosidine synthase activity Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine. got7fsn_ti 3-alpha(S)-strictosidine tryptamine-lyase activity|STR activity|strictosidine synthetase activity|3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming) RHEA:15013|KEGG_REACTION:R03738|MetaCyc:STRICTOSIDINE-SYNTHASE-RXN|EC:4.3.3.2 molecular_function owl:Class
GO:0072508 biolink:NamedThing trivalent inorganic cation homeostasis Any process involved in the maintenance of an internal steady state of trivalent cations within an organism or cell. got7fsn_ti Note that this term was split from 'di-, tri-valent inorganic cation homeostasis ; GO:0055066' (sibling term 'divalent inorganic cation homeostasis' ; GO:0072507'). mah 2010-12-16T03:26:40Z biological_process owl:Class
GO:0003864 biolink:NamedThing 3-methyl-2-oxobutanoate hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. got7fsn_ti ketopantoate hydroxymethyltransferase activity|alpha-ketoisovalerate hydroxymethyltransferase activity|dehydropantoate hydroxymethyltransferase activity|5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity|5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity|oxopantoate hydroxymethyltransferase activity EC:2.1.2.11|RHEA:11824|MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN molecular_function owl:Class
GO:0080099 biolink:NamedThing L-methionine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: L-methionine + 2-oxoglutarate = 4-methylthio-2-oxobutyrate + L-glutamate. got7fsn_ti L-methionine:alpha-ketoglutarate aminotransferase activity This reaction falls within the larger set of reactions associated with EC:2.6.1.5 (See BRENDA: http://www.brenda-enzymes.org/php/result_flat.php4?ecno=2.6.1.5). dhl 2009-04-23T03:51:20Z molecular_function owl:Class
GO:0046114 biolink:NamedThing guanosine biosynthetic process The chemical reactions and pathways resulting in the formation of guanine, guanine riboside, a nucleoside with a wide species distribution. got7fsn_ti guanosine biosynthesis|guanosine synthesis|guanosine formation|guanosine anabolism biological_process owl:Class
GO:0061146 biolink:NamedThing Peyer's patch morphogenesis The process in which a Peyer's patch is generated and organized. Peyer's patches are typically found as nodules associated with gut epithelium with distinct internal structures including B- and T-zones for the activation of lymphocytes. got7fsn_ti dph 2010-05-26T06:46:23Z biological_process owl:Class
GO:0009221 biolink:NamedThing pyrimidine deoxyribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti pyrimidine deoxyribonucleotide formation|pyrimidine deoxyribonucleotide anabolism|pyrimidine deoxyribonucleotide synthesis|pyrimidine deoxyribonucleotide biosynthesis MetaCyc:PWY0-166 biological_process owl:Class
GO:0035131 biolink:NamedThing post-embryonic pelvic fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion. got7fsn_ti biological_process owl:Class
GO:0000493 biolink:NamedThing box H/ACA snoRNP assembly The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex. got7fsn_ti box H/ACA small nucleolar ribonucleoprotein complex assembly biological_process owl:Class
GO:0035425 biolink:NamedThing autocrine signaling Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type. got7fsn_ti autocrine signalling bf 2010-03-29T02:15:52Z biological_process owl:Class
GO:0070708 biolink:NamedThing RNA cytidine insertion The modification of an RNA molecule by insertion of a cytidine nucleotide. got7fsn_ti RNA C insertion mah 2009-06-08T04:52:49Z biological_process owl:Class
GO:0045162 biolink:NamedThing clustering of voltage-gated sodium channels The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization. got7fsn_ti voltage-gated sodium channel clustering|Nav channel clustering|clustering of voltage gated sodium channels|clustering of voltage-dependent sodium channels biological_process owl:Class
GO:0034130 biolink:NamedThing toll-like receptor 1 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 1. got7fsn_ti toll-like receptor 1 signalling pathway|TLR1 signaling pathway biological_process owl:Class
GO:0070123 biolink:NamedThing transforming growth factor beta receptor activity, type III Combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors. got7fsn_ti type III TGF-beta receptor activity|betaglycan|type III TGFbeta receptor activity|type III transforming growth factor beta receptor activity|endoglin|transforming growth factor beta ligand binding to type III receptor molecular_function owl:Class
GO:0016039 biolink:NamedThing absorption of UV light The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm. got7fsn_ti biological_process owl:Class
GO:0061571 biolink:NamedThing TDP phosphorylation The process of introducing a phosphate group into TDP to produce a TTP. got7fsn_ti dph 2013-08-01T13:03:34Z biological_process owl:Class
GO:0099569 biolink:NamedThing presynaptic cytoskeleton The portion of the cytoskeleton contained within the presynapse. got7fsn_ti cellular_component owl:Class
GO:0034931 biolink:NamedThing 1-hydroxypyrene methyltransferase activity Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX. got7fsn_ti UM-BBD_reactionID:r0953 molecular_function owl:Class
GO:0103004 biolink:NamedThing 9,10-epoxystearate hydroxylase activity Catalysis of the reaction: H+ + 9,10-epoxystearate + O2 + NADPH <=> 9,10-epoxy-18-hydroxystearate + H2O + NADP. got7fsn_ti MetaCyc:RXN-9805 molecular_function owl:Class
GO:0070466 biolink:NamedThing alpha2-beta1 integrin-alpha3(VI) complex A protein complex that consists of an alpha2-beta1 integrin complex bound to a type VI collagen triple helix containing an alpha3(VI) chain. got7fsn_ti ITGA2-ITGB1-COL6A3 complex cellular_component owl:Class
GO:0006991 biolink:NamedThing response to sterol depletion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. got7fsn_ti sterol depletion response biological_process owl:Class
GO:1990468 biolink:NamedThing NuA3b histone acetyltransferase complex A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p. got7fsn_ti rb 2014-08-25T23:13:37Z cellular_component owl:Class
GO:0061614 biolink:NamedThing pri-miRNA transcription by RNA polymerase II The cellular synthesis of primary microRNA (pri-miRNA) transcripts from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. pri-miRNA transcripts are subsequently processed to produce the ~22nt miRNAs that function in gene regulation. got7fsn_ti pri-miRNA transcription from RNA polymerase II promoter https://github.com/geneontology/go-ontology/issues/14854 dph 2014-04-08T08:42:54Z biological_process owl:Class
GO:0042388 biolink:NamedThing gibberellic acid mediated signaling pathway, G-alpha-dependent A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors. got7fsn_ti gibberellic acid mediated signalling, G-alpha-dependent biological_process owl:Class
GO:0019327 biolink:NamedThing lead sulfide oxidation The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate. got7fsn_ti oxidation of lead sulfide|lead sulphide oxidation|oxidation of galena MetaCyc:P301-PWY biological_process owl:Class
GO:0000404 biolink:NamedThing heteroduplex DNA loop binding Binding to a DNA segment containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration. got7fsn_ti loop DNA binding molecular_function owl:Class
GO:0033696 biolink:NamedThing heterochromatin boundary formation A process that forms a boundary that limits the spreading of heterochromatin along a chromosome. got7fsn_ti negative regulation of extent of heterochromatin formation|negative regulation of heterochromatin spreading|negative regulation of extent of heterochromatin assembly|regulation of heterochromatin spreading|regulation of extent of heterochromatin assembly|regulation of extent of heterochromatin formation|maintenance of heterochromatin boundaries https://github.com/geneontology/go-ontology/issues/22028 GO:0031454 biological_process owl:Class
GO:0060844 biolink:NamedThing arterial endothelial cell fate commitment The commitment of a cell to an arterial endothelial cell fate and its capacity to differentiate into an arterial endothelial cell. got7fsn_ti dph 2009-08-12T10:49:00Z biological_process owl:Class
GO:0003178 biolink:NamedThing coronary sinus valve development The progression of the valve of the coronary sinus over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-08T11:21:43Z biological_process owl:Class
GO:0006436 biolink:NamedThing tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0048671 biolink:NamedThing negative regulation of collateral sprouting Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting. got7fsn_ti down-regulation of collateral sprouting|down regulation of collateral sprouting|inhibition of collateral sprouting|downregulation of collateral sprouting biological_process owl:Class
GO:0015848 biolink:NamedThing spermidine transport The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0005785 biolink:NamedThing signal recognition particle receptor complex A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex. got7fsn_ti docking protein complex|SR complex cellular_component owl:Class
GO:0035508 biolink:NamedThing positive regulation of myosin-light-chain-phosphatase activity Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity. got7fsn_ti bf 2010-04-30T10:55:05Z biological_process owl:Class
GO:0032516 biolink:NamedThing positive regulation of phosphoprotein phosphatase activity Any process that activates or increases the activity of a phosphoprotein phosphatase. got7fsn_ti up regulation of phosphoprotein phosphatase activity|upregulation of protein phosphatase 2 activity|positive regulation of calcineurin activity|up-regulation of protein phosphatase type 2A activity|stimulation of protein phosphatase type 2A activity|positive regulation of protein phosphatase type 2A activity|activation of calcineurin activity|calcineurin activation|stimulation of phosphoprotein phosphatase activity|upregulation of protein phosphatase type 2B activity|activation of protein phosphatase type 2A activity|up-regulation of protein phosphatase 2 activity|up regulation of protein phosphatase type 2B activity|activation of protein phosphatase 3 activity|stimulation of protein phosphatase 2 activity|up regulation of calcineurin activity|positive regulation of protein phosphatase 2 activity|up-regulation of protein phosphatase type 2B activity|activation of protein phosphatase type 2B activity|up regulation of protein phosphatase 3 activity|upregulation of protein phosphatase type 2A activity|positive regulation of protein phosphatase 3 activity|positive regulation of protein phosphatase type 2B activity|up regulation of protein phosphatase 2 activity|stimulation of protein phosphatase type 2B activity|upregulation of phosphoprotein phosphatase activity|up-regulation of phosphoprotein phosphatase activity|activation of phosphoprotein phosphatase activity|up regulation of protein phosphatase type 2A activity GO:0032514|GO:0034049 biological_process owl:Class
GO:0008240 biolink:NamedThing tripeptidyl-peptidase activity Catalysis of the release of an N-terminal tripeptide from a polypeptide. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 EC:3.4.14.10|EC:3.4.14.9|MetaCyc:3.4.14.10-RXN|MetaCyc:3.4.14.9-RXN molecular_function owl:Class
GO:0010364 biolink:NamedThing regulation of ethylene biosynthetic process Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process. got7fsn_ti biological_process owl:Class
GO:0031335 biolink:NamedThing regulation of sulfur amino acid metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids. got7fsn_ti regulation of sulfur amino acid metabolism biological_process owl:Class
GO:0102457 biolink:NamedThing cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-vanilloyl-beta-D-glucose <=> H+ + cyanidin 3,7-di-O-beta-D-glucoside betaine + vanillate. got7fsn_ti RHEA:35431|EC:2.4.1.300|MetaCyc:RXN-13969 molecular_function owl:Class
GO:0062022 biolink:NamedThing mitotic cohesin ssDNA (lagging strand) loading The ATP-dependent protein localization to chromatin by which a cohesin ring complex is topologically linked to ssDNA (lagging strand) which is already linked to a dsDNA (leading strand) molecule as part of the mitotic cell cycle. got7fsn_ti second-DNA capture dph 2018-04-06T13:06:36Z biological_process owl:Class
GO:0090566 biolink:NamedThing protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in). got7fsn_ti tb 2014-04-08T15:08:43Z molecular_function owl:Class
GO:0050344 biolink:NamedThing trans-cinnamate 2-monooxygenase activity Catalysis of the reaction: trans-cinnamate + H(+) + NADPH + O(2) = 2-coumarate + H(2)O + NADP(+). got7fsn_ti trans-cinnamate,NADPH:oxygen oxidoreductase (2-hydroxylating)|cinnamate 2-monooxygenase activity|cinnamic acid 2-hydroxylase activity|cinnamate 2-hydroxylase activity|cinnamic 2-hydroxylase activity|trans-cinnamic acid 2-hydroxylase activity MetaCyc:TRANS-CINNAMATE-2-MONOOXYGENASE-RXN|KEGG_REACTION:R02254|EC:1.14.13.14|RHEA:10956 molecular_function owl:Class
GO:0072523 biolink:NamedThing purine-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. got7fsn_ti purine-containing compound breakdown|purine and derivative catabolic process|purine-containing compound degradation|purine-containing compound catabolism mah 2011-01-04T03:17:20Z biological_process owl:Class
GO:0004023 biolink:NamedThing alcohol dehydrogenase activity, metal ion-independent Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion. got7fsn_ti molecular_function owl:Class
GO:1901466 biolink:NamedThing regulation of ferulate catabolic process Any process that modulates the frequency, rate or extent of ferulate catabolic process. got7fsn_ti regulation of ferulate breakdown|regulation of ferulate catabolism|regulation of ferulate degradation tt 2012-10-02T14:37:29Z biological_process owl:Class
GO:0070412 biolink:NamedThing R-SMAD binding Binding to a receptor-regulated SMAD signaling protein. got7fsn_ti pathway-restricted SMAD binding|receptor regulated SMAD binding|receptor-regulated SMAD binding|pathway restricted SMAD binding molecular_function owl:Class
GO:1990873 biolink:NamedThing intrinsic component of plasma membrane of cell tip The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip. got7fsn_ti al 2015-09-29T10:06:25Z cellular_component owl:Class
GO:0044577 biolink:NamedThing xylose catabolic process to ethanol The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, where one of the resulting products is ethanol. got7fsn_ti xylose catabolism to ethanol jl 2012-04-19T03:50:46Z biological_process owl:Class
GO:0042341 biolink:NamedThing cyanogenic glycoside metabolic process The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits. got7fsn_ti cyanogenic glycoside metabolism biological_process owl:Class
GO:0043513 biolink:NamedThing inhibin B complex Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit. got7fsn_ti Note that the actions of the inhibin complex are the opposite of those of the activin complex, which is a dimer of an inhibin beta-A and/or inhibin beta-B subunit. See also the cellular component term 'activin complex ; GO:0048180'. cellular_component owl:Class
GO:0070060 biolink:NamedThing 'de novo' actin filament nucleation The actin nucleation process in which actin monomers combine in the absence of any existing actin filaments; elongation of the actin oligomer formed by nucleation leads to the formation of an unbranched filament. got7fsn_ti formin-mediated actin filament nucleation|unbranched actin filament nucleation biological_process owl:Class
GO:0047689 biolink:NamedThing aspartate racemase activity Catalysis of the reaction: L-aspartate = D-aspartate. got7fsn_ti D-aspartate racemase activity MetaCyc:ASPARTATE-RACEMASE-RXN|EC:5.1.1.13|RHEA:14973|KEGG_REACTION:R00491 molecular_function owl:Class
GO:0002248 biolink:NamedThing connective tissue replacement involved in inflammatory response wound healing The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response. got7fsn_ti connective tissue replacement during inflammatory response|fibrosis during inflammatory response biological_process owl:Class
GO:0039003 biolink:NamedThing pronephric field specification The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop. got7fsn_ti pronephric kidney field specification bf 2010-07-02T09:28:16Z biological_process owl:Class
GO:0042585 biolink:NamedThing germinal vesicle The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity. got7fsn_ti primary oocyte nucleus cellular_component owl:Class
GO:0075069 biolink:NamedThing adhesion of symbiont infection cushion to host The attachment of an infection cushion of the symbiont to its host via adhesion molecules. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti adhesion of symbiont infection cushion to host during symbiotic interaction Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0071137 biolink:NamedThing alphaV-beta3 integrin-CD98 complex A protein complex that consists of an alphaV-beta3 integrin complex bound to the cell surface antigen CD98. got7fsn_ti ITGAV-ITGB3-SLC3A2 complex mah 2009-11-13T02:29:59Z cellular_component owl:Class
GO:0039022 biolink:NamedThing pronephric duct development The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney. got7fsn_ti bf 2010-07-02T10:15:03Z biological_process owl:Class
GO:0052754 biolink:NamedThing GTP:coenzyme F420 guanyltransferase activity Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate. got7fsn_ti GTP:coenzyme F420 guanylyltransferase activity|coenzyme F390-G synthetase activity ai 2011-09-22T03:25:30Z molecular_function owl:Class
GO:0047532 biolink:NamedThing 2,5-dioxopiperazine hydrolase activity Catalysis of the reaction: 2,5-dioxopiperazine + H(2)O = glycylglycine. got7fsn_ti cyclo(Gly-Gly) hydrolase activity|2,5-dioxopiperazine amidohydrolase activity|cyclo(glycylglycine) hydrolase activity EC:3.5.2.13|RHEA:21808|MetaCyc:25-DIOXOPIPERAZINE-HYDROLASE-RXN|KEGG_REACTION:R03810 molecular_function owl:Class
GO:0140698 biolink:NamedThing attachment of telomeric heterochromatin to nuclear envelope The process in which physical connections are formed between telomeric heterochromatin and the nuclear envelope, facilitating bouquet formation. got7fsn_ti heterochromatin organization|attachment of telomeric chromatin to nuclear envelope|attachment of telomeres to nuclear envelope https://github.com/geneontology/go-ontology/issues/22043 pg 2021-08-26T14:46:17Z biological_process owl:Class
GO:0010495 biolink:NamedThing long-distance posttranscriptional gene silencing A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place. got7fsn_ti long-distance propagation of posttranscriptional gene silencing biological_process owl:Class
GO:0042826 biolink:NamedThing histone deacetylase binding Binding to histone deacetylase. got7fsn_ti molecular_function owl:Class
GO:0102200 biolink:NamedThing N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity Catalysis of the reaction: H2O + an N-acylphosphatidylethanolamine = H+ + an N-acylethanolamine + a 1,2-diacyl-sn-glycerol 3-phosphate. got7fsn_ti MetaCyc:RXN-12116|RHEA:33159|EC:3.1.4.54 molecular_function owl:Class
GO:0035171 biolink:NamedThing lamellocyte differentiation The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes. got7fsn_ti lamellocyte cell differentiation biological_process owl:Class
GO:0034999 biolink:NamedThing oligosaccharyltransferase II complex An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes. got7fsn_ti OSTCII cellular_component owl:Class
GO:0008752 biolink:NamedThing FMN reductase activity Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+. got7fsn_ti NAD(P)H-FMN reductase activity|SsuE|NAD(P)H:flavin oxidoreductase activity|NAD(P)H(2):FMN oxidoreductase activity|NAD(P)H2 dehydrogenase (FMN)|riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity|NAD(P)H-dependent FMN reductase activity|NAD(P)H dehydrogenase (FMN) activity|flavin mononucleotide reductase activity|FMNH2:NAD(P)+ oxidoreductase activity|riboflavine mononucleotide reductase activity|NAD(P)H(2) dehydrogenase (FMN) activity|riboflavin mononucleotide reductase activity|flavine mononucleotide reductase activity|NAD(P)H:FMN oxidoreductase activity|NAD(P)H2:FMN oxidoreductase activity EC:1.5.1.39 molecular_function owl:Class
GO:0036243 biolink:NamedThing succinate-semialdehyde dehydrogenase (NADP+) activity Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+. got7fsn_ti succinate semialdehyde:NADP+ oxidoreductase activity|succinic semialdehyde dehydrogenase (NADP+) activity|succinyl semialdehyde dehydrogenase (NADP+) activity|NADP-dependent succinate-semialdehyde dehydrogenase activity This function is similar to EC:1.2.1.24 [succinate-semialdehyde dehydrogenase (NAD+)], and EC:1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NADP+. bf 2012-05-23T02:47:52Z RHEA:13213|EC:1.2.1.79 molecular_function owl:Class
GO:0047372 biolink:NamedThing acylglycerol lipase activity Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. got7fsn_ti monoacylglycerol hydrolase activity|glycerol-ester acylhydrolase activity|monoglyceride hydrolase activity|fatty acyl monoester lipase activity|monoglyceridyllipase activity|monoacylglycerolipase activity|monoglyceridase activity|monoglyceride lipase activity|monoacylglycerol lipase activity EC:3.1.1.23|Reactome:R-HSA-426032|Reactome:R-HSA-1482543|Reactome:R-HSA-163595|MetaCyc:3.1.1.23-RXN|Reactome:R-HSA-192422|Reactome:R-HSA-192430|Reactome:R-HSA-192434|RHEA:34019|Reactome:R-HSA-192425|Reactome:R-HSA-426043|Reactome:R-HSA-192475|Reactome:R-HSA-5694462 molecular_function owl:Class
GO:0033826 biolink:NamedThing xyloglucan 4-glucosyltransferase activity Catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose on to a glucose residue in xyloglucan, forming a beta-1,4-D-glucosyl-D-glucose linkage. got7fsn_ti xyloglucan glucosyltransferase activity|xyloglucan 4beta-D-glucosyltransferase activity|UDP-glucose:xyloglucan 1,4-beta-D-glucosyltransferase activity|UDPglucose:xyloglucan 1,4-beta-D-glucosyltransferase activity|uridine diphosphoglucose-xyloglucan 4beta-glucosyltransferase activity EC:2.4.1.168|MetaCyc:2.4.1.168-RXN molecular_function owl:Class
GO:0007415 biolink:NamedThing defasciculation of motor neuron axon Separation of a motor axon away from a bundle of axons known as a fascicle. got7fsn_ti biological_process owl:Class
GO:0103097 biolink:NamedThing CYP79F1 trihomomethionine monooxygenase activity Catalysis of the reaction: trihomomethionine + 2 O2 + 2 NADPH + 2 H+ <=> 3 H2O + carbon dioxide + 2 NADP + 6-methylthiohexanaldoxime. got7fsn_ti MetaCyc:RXNQT-4310|RHEA:32723 molecular_function owl:Class
GO:0047322 biolink:NamedThing [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity Catalysis of the reaction: [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] + ATP = [3-hydroxy-3-methylglutaryl-CoA reductase (NADPH)] phosphate + ADP. got7fsn_ti 3-hydroxy-3-methylglutaryl coenzyme A reductase kinase activity|hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating) activity|ATP:hydroxymethylglutaryl-CoA reductase (NADPH) phosphotransferase activity|AMPK|hydroxymethylglutaryl coenzyme A reductase kinase activity|3-hydroxy-3-methylglutaryl-CoA reductase kinase activity|STK29|hydroxymethylglutaryl-CoA reductase (NADPH2) kinase activity|reductase kinase activity|HMG-CoA reductase kinase activity|beta-hydroxy-beta-methylglutaryl-CoA reductase kinase activity|hydroxymethylglutaryl-CoA reductase kinase activity|hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity MetaCyc:2.7.1.109-RXN|RHEA:23172|EC:2.7.11.31 molecular_function owl:Class
GO:0030963 biolink:NamedThing peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine. got7fsn_ti RESID:AA0370 biological_process owl:Class
GO:0010499 biolink:NamedThing proteasomal ubiquitin-independent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin. got7fsn_ti biological_process owl:Class
GO:0052831 biolink:NamedThing inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate. got7fsn_ti ai 2011-11-29T10:58:27Z Reactome:R-HSA-1855159 molecular_function owl:Class
GO:0031503 biolink:NamedThing protein-containing complex localization A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location. got7fsn_ti protein complex localisation|establishment and maintenance of protein complex localization|protein complex localization biological_process owl:Class
GO:0102698 biolink:NamedThing 5-epi-aristolochene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-5-epi-aristolochene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-4781|RHEA:28635|EC:4.2.3.61 molecular_function owl:Class
GO:0002280 biolink:NamedThing monocyte activation involved in immune response The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. got7fsn_ti monocyte activation during immune response biological_process owl:Class
GO:0033702 biolink:NamedThing (+)-trans-carveol dehydrogenase activity Catalysis of the reaction: (1R,5S)-carveol + NAD(+) = (S)-carvone + H(+) + NADH. got7fsn_ti (+)-trans-carveol:NAD+ oxidoreductase activity MetaCyc:RXN-9397|KEGG_REACTION:R06117|RHEA:14825|EC:1.1.1.275 molecular_function owl:Class
GO:1900802 biolink:NamedThing cspyrone B1 biosynthetic process The chemical reactions and pathways resulting in the formation of cspyrone B1. got7fsn_ti cspyrone B1 anabolism|cspyrone B1 formation|cspyrone B1 synthesis|cspyrone B1 biosynthesis di 2012-06-04T09:51:06Z biological_process owl:Class
GO:0002203 biolink:NamedThing proteolysis by cytosolic proteases associated with antigen processing and presentation The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation. got7fsn_ti Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497). biological_process owl:Class
GO:0010347 biolink:NamedThing L-galactose-1-phosphate phosphatase activity Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate. got7fsn_ti RHEA:26349|MetaCyc:RXNQT-4142 molecular_function owl:Class
GO:0046929 biolink:NamedThing negative regulation of neurotransmitter secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a neurotransmitter. got7fsn_ti down-regulation of neurotransmitter secretion|down regulation of neurotransmitter secretion|inhibition of neurotransmitter secretion|conotoxin activity|downregulation of neurotransmitter secretion biological_process owl:Class
GO:0000417 biolink:NamedThing HIR complex A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p. got7fsn_ti HIRA complex cellular_component owl:Class
GO:0075506 biolink:NamedThing entry of viral genome into host nucleus through nuclear pore complex via importin Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery. got7fsn_ti entry of viral genome into host nucleus via cellular importin transport through the nuclear pore complex This mechanism is used by some RNA viruses (e.g. Orthomyxoviridae), some dsDNA viruses (e.g. Polyomaviridae) and some ssRNA viruses (e.g. Lentivirus). jl 2011-07-26T04:36:46Z biological_process owl:Class
GO:0071135 biolink:NamedThing alpha7-beta1 integrin-focal adhesion kinase complex A protein complex that consists of an alpha7-beta1 integrin complex bound to focal adhesion kinase. got7fsn_ti ITGA7-ITGB1-PTK2 complex mah 2009-11-13T02:29:24Z cellular_component owl:Class
GO:0097744 biolink:NamedThing urate salt excretion The elimination by an organism of urate salt or uric acid. got7fsn_ti urate excretion pr 2016-10-27T11:35:59Z biological_process owl:Class
GO:0000494 biolink:NamedThing box C/D RNA 3'-end processing Any process involved in forming the mature 3' end of a box C/D RNA molecule. got7fsn_ti box C/D snoRNA 3'-end processing|box C/D RNA 3' end processing|box C/D sRNA 3'-end processing https://github.com/geneontology/go-ontology/issues/20416 biological_process owl:Class
GO:0046608 biolink:NamedThing carotenoid isomerase activity Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids. got7fsn_ti molecular_function owl:Class
GO:0030911 biolink:NamedThing TPR domain binding Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. got7fsn_ti tetratricopeptide repeat domain binding molecular_function owl:Class
GO:0061479 biolink:NamedThing response to reverse transcriptase inhibitor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus. got7fsn_ti dph 2012-11-07T09:10:51Z biological_process owl:Class
GO:0051266 biolink:NamedThing sirohydrochlorin ferrochelatase activity Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. got7fsn_ti sirohydrochlorin ferro-lyase activity|Met8P|SirB|CysG|siroheme synthase activity|siroheme ferro-lyase (sirohydrochlorin-forming) RHEA:24360|MetaCyc:SIROHEME-FERROCHELAT-RXN|EC:4.99.1.4|KEGG_REACTION:R02864 molecular_function owl:Class
GO:0009703 biolink:NamedThing nitrate reductase (NADH) activity Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+. got7fsn_ti NADH-nitrate reductase activity|assimilatory NADH:nitrate reductase activity|NADH:nitrate oxidoreductase activity|assimilatory nitrate reductase activity|nitrate reductase (NADH2)|NADH:nitrate reductase activity|NADH-dependent nitrate reductase activity|nitrate reductase (NADH(2)) activity|nitrite:NAD+ oxidoreductase activity|assimilatory NADH: nitrate reductase activity Note that this function was formerly EC:1.6.6.1. EC:1.7.1.1|RHEA:17913|MetaCyc:NITRATE-REDUCTASE-NADH-RXN molecular_function owl:Class
GO:0034902 biolink:NamedThing endosulfan sulfate hydrolase activity Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite. got7fsn_ti UM-BBD_reactionID:r1387 molecular_function owl:Class
GO:0018266 biolink:NamedThing GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine|GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine RESID:AA0159 biological_process owl:Class
GO:0070223 biolink:NamedThing sulfide oxidation, using sulfur dioxygenase A sulfide oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase. got7fsn_ti sulphide oxidation, using sulfur dioxygenase MetaCyc:PWY-5285 biological_process owl:Class
GO:0021671 biolink:NamedThing rhombomere 7 morphogenesis The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0047526 biolink:NamedThing 2'-hydroxyisoflavone reductase activity Catalysis of the reaction: vestitone + NADP+ = 2'-hydroxyformononetin + NADPH + H+. got7fsn_ti NADPH:2'-hydroxyisoflavone oxidoreductase activity|isoflavone reductase activity|vestitone:NADP+ oxidoreductase activity|2',7-dihydroxy-4',5'-methylenedioxyisoflavone reductase activity RHEA:22560|MetaCyc:2-HYDROXYISOFLAVONE-REDUCTASE-RXN|EC:1.3.1.45 molecular_function owl:Class
GO:0099573 biolink:NamedThing glutamatergic postsynaptic density The post-synaptic specialization of a glutamatergic excitatory synapse. got7fsn_ti postsynaptic specialization, glutamatergic neuron-to-neuron synapse cellular_component owl:Class
GO:0050305 biolink:NamedThing strombine dehydrogenase activity Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H(2)O + NAD(+) = glycine + H(+) + NADH + pyruvate. got7fsn_ti strombine[N-(carboxymethyl)-D-alanine]dehydrogenase activity|N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase activity|N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming) EC:1.5.1.22|RHEA:14061|KEGG_REACTION:R00368|MetaCyc:STROMBINE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0055004 biolink:NamedThing atrial cardiac myofibril assembly The process whose specific outcome is the progression of the atrial cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells. got7fsn_ti atrial heart myofibril development|atrial cardiac myofibril development biological_process owl:Class
GO:1990125 biolink:NamedThing DiaA complex A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation. got7fsn_ti DiaA homotetramer bhm 2013-06-13T14:03:54Z cellular_component owl:Class
GO:0071960 biolink:NamedThing maintenance of mitotic sister chromatid cohesion, centromeric The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a mitotic cell cycle. got7fsn_ti maintenance of mitotic sister chromatin cohesion at centromere|maintenance of centromeric mitotic sister chromatin cohesion|maintenance of sister chromatin cohesion at centromere at mitosis mah 2011-06-01T04:10:59Z biological_process owl:Class
GO:0042843 biolink:NamedThing D-xylose catabolic process The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide. got7fsn_ti D-xylose catabolism|D-xylose breakdown|D-xylose degradation biological_process owl:Class
GO:0033412 biolink:NamedThing UAG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UAG codon. got7fsn_ti TAG codon-amino acid adaptor activity Note that in the standard genetic code, TAG is a stop codon (amber) and is not normally read by a tRNA. molecular_function owl:Class
GO:0018423 biolink:NamedThing protein C-terminal leucine carboxyl O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein. got7fsn_ti protein-leucine O-methyltransferase activity|protein phosphatase methyltransferase activity Reactome:R-HSA-8856945 molecular_function owl:Class
GO:0047811 biolink:NamedThing D-alanine gamma-glutamyltransferase activity Catalysis of the reaction: D-alanine + L-glutamine = gamma-L-glutamyl-D-alanine + NH(4)(+). got7fsn_ti L-glutamine:D-alanine gamma-glutamyltransferase activity|D-alanine g-glutamyltransferase activity RHEA:23556|KEGG_REACTION:R01149|EC:2.3.2.14|MetaCyc:D-ALANINE-GAMMA-GLUTAMYLTRANSFERASE-RXN molecular_function owl:Class
GO:0016457 biolink:NamedThing dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster. got7fsn_ti dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome biological_process owl:Class
GO:0047377 biolink:NamedThing 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase activity Catalysis of the reaction: 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H(2)O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+). got7fsn_ti 5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene acetylhydrolase activity|diacetoxybutynylbithiophene acetate esterase activity|3,4-diacetoxybutinylbithiophene:4-acetate esterase activity KEGG_REACTION:R04525|EC:3.1.1.66|MetaCyc:3.1.1.66-RXN|RHEA:16313 molecular_function owl:Class
GO:0050094 biolink:NamedThing methionine-glyoxylate transaminase activity Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine. got7fsn_ti MGAT activity|L-methionine:glyoxylate aminotransferase activity|methionine-glyoxylate aminotransferase activity KEGG_REACTION:R00652|EC:2.6.1.73|RHEA:22884|MetaCyc:METHIONINE--GLYOXYLATE-TRANSAMINASE-RXN molecular_function owl:Class
GO:0018755 biolink:NamedThing 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-. got7fsn_ti molecular_function owl:Class
GO:0070552 biolink:NamedThing BRISC complex A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains. got7fsn_ti cellular_component owl:Class
GO:0072669 biolink:NamedThing tRNA-splicing ligase complex A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. got7fsn_ti tRNA splicing ligase complex mah 2011-02-18T10:55:26Z MetaCyc:ENTMULTI-CPLX cellular_component owl:Class
GO:0046503 biolink:NamedThing glycerolipid catabolic process The chemical reactions and pathways resulting in the breakdown of glycerolipids, any lipid with a glycerol backbone. got7fsn_ti glycerolipid catabolism|glycerolipid degradation|glycerolipid breakdown biological_process owl:Class
GO:0035635 biolink:NamedThing entry of bacterium into host cell The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti invasion of bacteria into host cell|bacterial entry into host cell bf 2011-01-13T02:26:54Z biological_process owl:Class
GO:0047381 biolink:NamedThing dodecanoyl-[acyl-carrier-protein] hydrolase activity Catalysis of the reaction: H2O + dodecanoyl-[acyl-carrier protein] = dodecanoate + [acyl-carrier protein]. got7fsn_ti lauryl-acyl-carrier protein hydrolase activity|dodecanoyl-acyl-carrier-protein hydrolase activity|lauryl-acyl-carrier-protein hydrolase activity|lauroyl-[acyl-carrier-protein] hydrolase activity|dodecyl-[acyl-carrier protein] hydrolase activity|dodecanoyl-ACP hydrolase activity|dodecyl-acyl-carrier protein hydrolase|lauroyl-ACP hydrolase activity|dodecanoyl-[acyl-carrier protein] hydrolase activity|lauryl-[acyl-carrier protein] hydrolase activity GO:0016294 EC:3.1.2.21|MetaCyc:3.1.2.21-RXN|RHEA:30119 molecular_function owl:Class
GO:0017172 biolink:NamedThing cysteine dioxygenase activity Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+). got7fsn_ti EC:1.13.11.20|RHEA:20441|KEGG_REACTION:R00893|MetaCyc:CYSTEINE-DIOXYGENASE-RXN|Reactome:R-HSA-1614645 molecular_function owl:Class
GO:0039716 biolink:NamedThing viroplasm viral factory A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae. got7fsn_ti bf 2013-12-19T15:22:29Z Wikipedia:Viroplasm cellular_component owl:Class
GO:0015670 biolink:NamedThing carbon dioxide transport The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1990045 biolink:NamedThing sclerotium development The process whose specific outcome is the progression of the sclerotium over time, from its formation to the mature structure. A sclerotium is a mycelial resting body, resistant to adverse environmental conditions. got7fsn_ti pr 2013-02-15T15:30:00Z biological_process owl:Class
GO:0002545 biolink:NamedThing chronic inflammatory response to non-antigenic stimulus A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma. got7fsn_ti biological_process owl:Class
GO:0008143 biolink:NamedThing poly(A) binding Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. got7fsn_ti polyadenylate binding|poly-A binding|poly(A) binding, within an RNA molecule|poly(rA) binding molecular_function owl:Class
GO:0050561 biolink:NamedThing glutamate-tRNA(Gln) ligase activity Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP. got7fsn_ti L-glutamate:tRNAGlx ligase (AMP-forming)|glutamate-tRNAGln ligase activity|nondiscriminating glutamyl-tRNA synthetase activity MetaCyc:6.1.1.24-RXN|EC:6.1.1.24|RHEA:18397 molecular_function owl:Class
GO:0102139 biolink:NamedThing 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity Catalysis of the reaction: (2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + (2E)-2-hydroxypenta-2,4-dienoate. got7fsn_ti MetaCyc:RXN-11543|EC:3.7.1.13|RHEA:27870 molecular_function owl:Class
GO:0120221 biolink:NamedThing maintenance of ciliary planar beating movement pattern Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement. got7fsn_ti Note that we deem cilium and microtubule-based flagellum to be equivalent. krc 2019-12-10T21:34:54Z biological_process owl:Class
GO:1990454 biolink:NamedThing L-type voltage-gated calcium channel complex A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. got7fsn_ti cardiac muscle L-type voltage-gated calcium channel complex|skeletal muscle L-type voltage-gated calcium channel complex Examples of this are CACNA1S, CACNA2D1, CACNB1, CACNG1 in rabbit (UniProt symbol P07293, P13806, P19517 and P19518) in PMID:12946355 (inferred from direct assay). anm 2014-08-12T17:22:10Z cellular_component owl:Class
GO:0060962 biolink:NamedThing regulation of ribosomal protein gene transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II. got7fsn_ti regulation of ribosomal protein gene transcription from RNA polymerase II promoter dph 2009-10-05T03:00:40Z biological_process owl:Class
GO:0042565 biolink:NamedThing RNA nuclear export complex A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore. got7fsn_ti cellular_component owl:Class
GO:0039553 biolink:NamedThing suppression by virus of host chemokine activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity. got7fsn_ti down-regulation by virus of host chemokine activity|downregulation by virus of host chemokine activity|negative regulation by virus of host chemokine activity|inhibition of host chemokines by virus|inhibition by virus of host chemokine activity bf 2012-02-28T01:29:55Z VZ:813 biological_process owl:Class
GO:0039518 biolink:NamedThing suppression by virus of host cytokine activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity. got7fsn_ti down-regulation by virus of host cytokine activity|inhibition by virus of host cytokine activity|downregulation by virus of host cytokine activity|negative regulation by virus of host cytokine activity bf 2011-06-22T04:09:41Z biological_process owl:Class
GO:0071888 biolink:NamedThing macrophage apoptotic process Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues. got7fsn_ti activation-induced cell death|AICD|macrophage apoptosis Note that a lymphocyte is a cell of the B cell, T cell, or natural killer cell lineage (CL:0000542). mah 2010-09-14T12:50:40Z biological_process owl:Class
GO:0003243 biolink:NamedThing circumferential growth involved in left ventricle morphogenesis The morphogenetic growth in which the left ventricle grows expanding its external boundary. got7fsn_ti dph 2009-10-13T11:33:09Z biological_process owl:Class
GO:0045759 biolink:NamedThing negative regulation of action potential Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti inhibition of action potential|down-regulation of action potential|downregulation of action potential|down regulation of action potential biological_process owl:Class
GO:0035764 biolink:NamedThing dorsal motor nucleus of vagus nerve formation The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. got7fsn_ti bf 2011-03-29T02:48:26Z biological_process owl:Class
GO:0043770 biolink:NamedThing demethylmenaquinone methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.163 molecular_function owl:Class
GO:0033768 biolink:NamedThing SUMO-targeted ubiquitin ligase complex A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes. got7fsn_ti cellular_component owl:Class
GO:0097063 biolink:NamedThing cadmium ion sensor activity Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++). got7fsn_ti pr 2011-06-08T09:46:14Z molecular_function owl:Class
GO:0046870 biolink:NamedThing cadmium ion binding Binding to a cadmium ion (Cd). got7fsn_ti Cd ion binding|copper/cadmium binding|cadmium binding molecular_function owl:Class
GO:0032427 biolink:NamedThing GBD domain binding Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac. got7fsn_ti PMD binding|P21-Rho-binding domain binding|Cdc42/Rac interactive binding motif binding|CRIB motif binding molecular_function owl:Class
GO:0036324 biolink:NamedThing vascular endothelial growth factor receptor-2 signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGFR2 signaling pathway|KDR signaling pathway|VEGFR-2 signaling pathway|FLK-1 signaling pathway bf 2012-09-04T15:15:40Z biological_process owl:Class
GO:0033918 biolink:NamedThing kappa-carrageenase activity Catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose in kappa-carrageenans. got7fsn_ti kappa-carrageenan 4-beta-D-glycanohydrolase (configuration-retaining) activity|kappa-carrageenan 4-beta-D-glycanohydrolase activity MetaCyc:3.2.1.83-RXN|EC:3.2.1.83 molecular_function owl:Class
GO:0001836 biolink:NamedThing release of cytochrome c from mitochondria The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. got7fsn_ti The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011. biological_process owl:Class
GO:0036522 biolink:NamedThing negative regulation by symbiont of host protein localization to phagocytic vesicle Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti suppression of host protein localisation to phagosome|disruption of host protein localisation to phagosome|inhibition of host protein localisation to phagosome bf 2016-06-06T14:49:51Z biological_process owl:Class
GO:0021808 biolink:NamedThing cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration. got7fsn_ti cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration biological_process owl:Class
GO:0003979 biolink:NamedThing UDP-glucose 6-dehydrogenase activity Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate. got7fsn_ti KEGG_REACTION:R00286|MetaCyc:UGD-RXN|RHEA:23596|Reactome:R-HSA-173597|EC:1.1.1.22 molecular_function owl:Class
GO:0018473 biolink:NamedThing cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid. got7fsn_ti UM-BBD_reactionID:r0744 molecular_function owl:Class
GO:0034000 biolink:NamedThing chondroitin-sulfate-ABC endolyase activity Catalysis of the endolytic cleavage of beta-1,4-galactosaminic bonds between N-acetylgalactosamine and either D-glucuronic acid or L-iduronic acid to produce a mixture of Delta4-unsaturated oligosaccharides of different sizes that are ultimately degraded to Delta4-unsaturated tetra- and disaccharides. got7fsn_ti chondroitin sulfate ABC lyase activity|chondroitin ABC eliminase activity|chondroitin sulfate ABC endoeliminase activity|ChS ABC lyase activity|chondroitinase ABC activity|chondroitin sulfate ABC endolyase activity|ChS ABC lyase I activity|chondroitinase activity EC:4.2.2.20|MetaCyc:4.2.2.20-RXN molecular_function owl:Class
GO:0097186 biolink:NamedThing amelogenesis The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. got7fsn_ti enamel development pr 2011-11-21T09:01:24Z biological_process owl:Class
GO:0030544 biolink:NamedThing Hsp70 protein binding Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. got7fsn_ti molecular_function owl:Class
GO:0034748 biolink:NamedThing Par3-APC-KIF3A complex A protein complex that contains Par3, the tumor suppressor protein adenomatous polyposis coli (APC), and the kinesin-related protein KIF3A; involved in establishing neuronal cell polarity. got7fsn_ti Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. cellular_component owl:Class
GO:0043889 biolink:NamedThing (S)-3-O-geranylgeranylglyceryl phosphate synthase activity Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate. got7fsn_ti (S)-GGGP synthase activity|GGGPS|GGGP synthase activity|(S)-3-O-geranylgeranylglycerylphosphate synthase activity This function is involved in archaeal lipid synthesis. molecular_function owl:Class
GO:0050350 biolink:NamedThing trihydroxystilbene synthase activity Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. got7fsn_ti malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)|stilbene synthase activity|resveratrol synthase activity MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN|RHEA:11936|EC:2.3.1.95 molecular_function owl:Class
GO:0080133 biolink:NamedThing midchain alkane hydroxylase activity Catalysis of the conversion of an alkane to a secondary alcohol. got7fsn_ti dhl 2009-05-06T04:46:17Z molecular_function owl:Class
GO:0010839 biolink:NamedThing negative regulation of keratinocyte proliferation Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class
GO:0031609 biolink:NamedThing cytosolic proteasome core complex, beta-subunit complex The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex. got7fsn_ti cellular_component owl:Class
GO:0010515 biolink:NamedThing negative regulation of induction of conjugation with cellular fusion Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion. got7fsn_ti biological_process owl:Class
GO:0015349 biolink:NamedThing thyroid hormone transmembrane transporter activity Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. got7fsn_ti Reactome:R-HSA-879575|Reactome:R-HSA-9631987 molecular_function owl:Class
GO:0097013 biolink:NamedThing phagocytic vesicle lumen The volume enclosed by the membrane of a phagocytic vesicle. got7fsn_ti pr 2011-03-22T01:44:47Z cellular_component owl:Class
GO:0030767 biolink:NamedThing 3-hydroxyanthranilate 4-C-methyltransferase activity Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity|3-hydroxyanthranilate 4-methyltransferase activity RHEA:17833|EC:2.1.1.97|MetaCyc:2.1.1.97-RXN|KEGG_REACTION:R02667 molecular_function owl:Class
GO:0034959 biolink:NamedThing endothelin maturation The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin. got7fsn_ti https://github.com/geneontology/go-ontology/issues/15384 biological_process owl:Class
GO:0003240 biolink:NamedThing conus arteriosus formation The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk. got7fsn_ti dph 2009-10-13T11:25:47Z biological_process owl:Class
GO:0031878 biolink:NamedThing type 1 somatostatin receptor binding Binding to a type 1 somatostatin receptor. got7fsn_ti type 1 somatostatin receptor ligand molecular_function owl:Class
GO:0048270 biolink:NamedThing methionine adenosyltransferase regulator activity Binds to and modulates the activity of methionine adenosyltransferase. got7fsn_ti MAT regulator activity See also the molecular function term 'methionine adenosyltransferase activity ; GO:0004478'. molecular_function owl:Class
GO:0050973 biolink:NamedThing detection of mechanical stimulus involved in equilibrioception The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears. got7fsn_ti equilibrioception, detection of mechanical stimulus|equilibrioception, sensory detection of mechanical stimulus|sensory detection of mechanical stimulus during equilibrioception|equilibrioception, sensory transduction of mechanical stimulus|sensory transduction of mechanical stimulus during equilibrioception biological_process owl:Class
GO:0034012 biolink:NamedThing FAD-AMP lyase (cyclizing) activity Catalysis of the reaction: FAD = AMP + riboflavin cyclic-4',5'-phosphate. got7fsn_ti FMN cyclase activity|FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) activity|FAD AMP-lyase (cyclic-FMN-forming) activity EC:4.6.1.15|RHEA:13729 molecular_function owl:Class
GO:0008902 biolink:NamedThing hydroxymethylpyrimidine kinase activity Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+). got7fsn_ti hydroxymethylpyrimidine kinase (phosphorylating)|ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity MetaCyc:OHMETPYRKIN-RXN|RHEA:23096|EC:2.7.1.49|KEGG_REACTION:R03471 molecular_function owl:Class
GO:0030590 biolink:NamedThing first cell cycle pseudocleavage A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms. got7fsn_ti biological_process owl:Class
GO:0034768 biolink:NamedThing (E)-beta-ocimene synthase activity Catalysis of the reaction: geranyl diphosphate = (E)-beta-ocimene + diphosphate. got7fsn_ti EC:4.2.3.106|RHEA:32691|MetaCyc:RXN-5109 molecular_function owl:Class
GO:0098614 biolink:NamedThing hydrogen selenide methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol. got7fsn_ti Reactome:R-HSA-2408536 molecular_function owl:Class
GO:0070448 biolink:NamedThing laricitrin 5'-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin. got7fsn_ti S-adenosyl-L-methionine:myricetin O-methyltransferase activity|CrCOMT2|flavonoid 3',5'-O-dimethyltransferase activity Note that this term represents one of two reactions that are grouped together in EC:2.1.1.267. MetaCyc:RXN-8452|KEGG_REACTION:R06816|RHEA:25633|EC:2.1.1.267 molecular_function owl:Class
GO:0071962 biolink:NamedThing mitotic sister chromatid cohesion, centromeric The cell cycle process in which centromeres of sister chromatids are joined during mitosis. got7fsn_ti centromeric mitotic sister chromatin cohesion|mitotic sister chromatid cohesion at centromere|sister chromatid cohesion at centromere at mitosis mah 2011-06-02T11:24:17Z biological_process owl:Class
GO:0080115 biolink:NamedThing myosin XI tail binding Binding to the tail region of a myosin XI heavy chain. got7fsn_ti dhl 2009-04-27T03:31:45Z molecular_function owl:Class
GO:0045353 biolink:NamedThing interleukin-1 type II receptor antagonist activity Blocks the binding of interleukin-1 to interleukin-1 type II receptors. got7fsn_ti IL-1ra type II molecular_function owl:Class
GO:0051867 biolink:NamedThing general adaptation syndrome, behavioral process The set of behavioral processes that occur as part of the general adaptation syndrome, the response of the body to a strong, stressful stimulus. got7fsn_ti general adaptation syndrome, behavioral response|behavioural response during general adaptation syndrome|behavioral process during general adaptation syndrome|behavioural process during general adaptation syndrome|behavioral response during general adaptation syndrome|general adaptation syndrome, behavioural response|general adaptation syndrome, behavioural process biological_process owl:Class
GO:0047889 biolink:NamedThing ferredoxin-nitrate reductase activity Catalysis of the reaction: nitrite + H2O + 2 oxidized ferredoxin = nitrate + 2 reduced ferredoxin. got7fsn_ti assimilatory nitrate reductase activity|nitrate (ferredoxin) reductase activity|nitrite:ferredoxin oxidoreductase activity|assimilatory ferredoxin-nitrate reductase activity EC:1.7.7.2|MetaCyc:1.7.7.2-RXN|RHEA:21828 molecular_function owl:Class
GO:0052062 biolink:NamedThing induction by symbiont of host phytoalexin production The activation by a symbiont of the production of phytoalexins as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti induction by organism of phytoalexin production in other organism involved in symbiotic interaction|activation by organism of host phytoalexin production GO:0052262 biological_process owl:Class
GO:0070316 biolink:NamedThing regulation of G0 to G1 transition A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase. got7fsn_ti biological_process owl:Class
GO:0106078 biolink:NamedThing histone succinyltransferase activity Catalysis of the reaction: succinyl-CoA + histone = CoA + succinyl-histone. got7fsn_ti hjd 2017-12-15T18:29:40Z molecular_function owl:Class
GO:0003426 biolink:NamedThing cytoskeleton polarization involved in growth plate cartilage chondrocyte division A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell. got7fsn_ti dph 2009-12-22T11:38:22Z biological_process owl:Class
GO:0048722 biolink:NamedThing anterior cibarial plate development The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0102873 biolink:NamedThing 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:1-2-16:0-digalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:2-2-16:0-digalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.23|MetaCyc:RXN-8363 molecular_function owl:Class
GO:0039564 biolink:NamedThing suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2). got7fsn_ti suppression by virus of host STAT2 activity|inhibition of host STAT2 by virus|inhibition by virus of host STAT2 activity https://github.com/geneontology/go-ontology/issues/21963 bf 2012-03-12T02:52:34Z biological_process owl:Class
GO:0097536 biolink:NamedThing thymus epithelium morphogenesis The process in which the thymus epithelium is generated and organized. got7fsn_ti thymic epithelium morphogenesis pr 2013-11-28T10:51:03Z biological_process owl:Class
GO:0106255 biolink:NamedThing hydroperoxy icosatetraenoate isomerase activity A hydroperoxy icosatetraenoate <=> a hydroxy epoxy icosatrienoate. got7fsn_ti hjd 2020-03-20T14:00:30Z EC:5.4.4.7|RHEA:55560 molecular_function owl:Class
GO:0010514 biolink:NamedThing induction of conjugation with cellular fusion The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types. got7fsn_ti biological_process owl:Class
GO:0048285 biolink:NamedThing organelle fission The creation of two or more organelles by division of one organelle. got7fsn_ti biological_process owl:Class
GO:0103100 biolink:NamedThing UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 6-methylthiohexylhydroximate <=> H+ + 5-methylthiopentyldesulfoglucosinolate + UDP(3-). got7fsn_ti MetaCyc:RXNQT-4325|EC:2.4.1.195 molecular_function owl:Class
GO:0050122 biolink:NamedThing N-acylhexosamine oxidase activity Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + O(2) = N-acetyl-D-glucosaminate + H(2)O(2) + H(+). got7fsn_ti N-acyl-D-hexosamine:oxygen 1-oxidoreductase activity|N-acyl-beta-D-hexosamine:oxygen 1-oxidoreductase activity|N-acyl-D-hexosamine oxidase activity KEGG_REACTION:R01203|MetaCyc:N-ACYLHEXOSAMINE-OXIDASE-RXN|RHEA:13029|EC:1.1.3.29 molecular_function owl:Class
GO:0090612 biolink:NamedThing cAMP deaminase activity Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3. got7fsn_ti cyclic adenosine monophosphate deaminase activity tb 2014-10-23T15:46:42Z EC:3.5.4.46|RHEA:22908 molecular_function owl:Class
GO:0014814 biolink:NamedThing axon regeneration at neuromuscular junction The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones. got7fsn_ti biological_process owl:Class
GO:1990528 biolink:NamedThing Rvs161p-Rvs167p complex A protein complex that is involved in endocytosis in the yeast S. cerevisiae. got7fsn_ti rb 2014-11-05T23:11:32Z cellular_component owl:Class
GO:0072059 biolink:NamedThing cortical collecting duct development The process whose specific outcome is the progression of the cortical collecting duct over time, from its formation to the mature structure. The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex. got7fsn_ti mah 2010-01-25T04:07:07Z biological_process owl:Class
GO:0031852 biolink:NamedThing mu-type opioid receptor binding Binding to a mu-type opioid receptor. got7fsn_ti mu-type opioid receptor ligand|morphine receptor binding molecular_function owl:Class
GO:0042039 biolink:NamedThing vanadium incorporation into metallo-sulfur cluster The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n). got7fsn_ti vanadium incorporation into metallo-sulphur cluster biological_process owl:Class
GO:0050582 biolink:NamedThing xylitol oxidase activity Catalysis of the reaction: xylitol + O2 = xylose + H2O2. got7fsn_ti xylitol:oxygen oxidoreductase activity EC:1.1.3.41|MetaCyc:1.1.3.41-RXN molecular_function owl:Class
GO:0018395 biolink:NamedThing peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine. got7fsn_ti RESID:AA0028 biological_process owl:Class
GO:0036443 biolink:NamedThing dermatan 6-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate. got7fsn_ti bf 2013-10-17T10:41:48Z KEGG_REACTION:R07288 molecular_function owl:Class
GO:0008833 biolink:NamedThing deoxyribonuclease IV (phage-T4-induced) activity Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products. got7fsn_ti E. coli endonuclease IV|deoxyribonuclease IV (phage T4-induced) activity|Escherichia coli endonuclease II|endodeoxyribonuclease IV (phage T(4)-induced) activity|redoxyendonuclease activity|endodeoxyribonuclease IV (phage T4-induced) activity|endonuclease IV activity|deoxriboendonuclease activity|endonuclease II|DNA-adenine-transferase activity EC:3.1.21.2|MetaCyc:3.1.21.2-RXN molecular_function owl:Class
GO:0090332 biolink:NamedThing stomatal closure The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange. got7fsn_ti tb 2010-05-26T02:14:49Z biological_process owl:Class
GO:0103084 biolink:NamedThing methylthiobutylmalate dehydrogenase activity Catalysis of the reaction: 3-(4'-methylthio)butylmalate <=> H+ + 2-oxo-7-methylthioheptanoate + carbon dioxide. got7fsn_ti MetaCyc:RXNQT-4168 molecular_function owl:Class
GO:0034682 biolink:NamedThing integrin alphav-beta1 complex An integrin complex that comprises one alphav subunit and one beta1 subunit. got7fsn_ti ITGAV-ITGB1 complex|alphav-beta1 integrin complex cellular_component owl:Class
GO:0046918 biolink:NamedThing N-terminal peptidyl-glycine N-palmitoylation The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal glycine residue to form N-palmitoyl-glycine. got7fsn_ti Palmitoylation of glycine only occurs when glycine is at the N-terminal position of a protein. RESID:AA0339 biological_process owl:Class
GO:0005758 biolink:NamedThing mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope. got7fsn_ti mitochondrial membrane lumen|mitochondrial envelope lumen GO:0031971 NIF_Subcellular:sao118944228 cellular_component owl:Class
GO:0004947 biolink:NamedThing bradykinin receptor activity Combining with bradykinin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0034675 biolink:NamedThing integrin alpha6-beta1 complex An integrin complex that comprises one alpha6 subunit and one beta1 subunit. got7fsn_ti VLA-6 complex|alpha6-beta1 integrin complex|ITGA6-ITGB1 complex cellular_component owl:Class
GO:0097029 biolink:NamedThing mature conventional dendritic cell differentiation The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells. got7fsn_ti Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. pr 2011-04-01T10:10:22Z biological_process owl:Class
GO:0097028 biolink:NamedThing dendritic cell differentiation The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. got7fsn_ti Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'. pr 2011-04-01T10:08:42Z biological_process owl:Class
GO:0035371 biolink:NamedThing microtubule plus-end The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability. got7fsn_ti microtubule plus end|growing microtubule plus end bf 2010-03-11T10:55:00Z cellular_component owl:Class
GO:0003060 biolink:NamedThing negative regulation of the force of heart contraction by acetylcholine The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction. got7fsn_ti decreased force of heart contraction by acetylcholine biological_process owl:Class
GO:0102866 biolink:NamedThing di-homo-gamma-linolenate delta5 desaturase activity Catalysis of the reaction: all-cis-icosa-8,11,14-trienoate + O2 + a reduced electron acceptor <=> arachidonate + 2 H2O + an oxidized electron acceptor. got7fsn_ti RHEA:46260|MetaCyc:RXN-8346 molecular_function owl:Class
GO:0033902 biolink:NamedThing rRNA endonuclease activity Catalysis of the hydrolysis of the phosphodiester linkage between guanosine and adenosine residues at one specific position in 28S rRNA from rat ribosomes. got7fsn_ti alpha-sarcin EC:4.6.1.23|MetaCyc:3.1.27.10-RXN molecular_function owl:Class
GO:0010177 biolink:NamedThing 2-(2'-methylthio)ethylmalate synthase activity Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+. got7fsn_ti methylthioalkylmalate synthase activity MetaCyc:RXN-2202|EC:2.3.3.17 molecular_function owl:Class
GO:0016707 biolink:NamedThing gibberellin 3-beta-dioxygenase activity Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2. got7fsn_ti gibberellin 3beta-hydroxylase activity|(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)|(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)|gibberellin 3-beta-hydroxylase activity|gibberellin 3beta-dioxygenase activity EC:1.14.11.15|MetaCyc:RXN1F-170|RHEA:10104 molecular_function owl:Class
GO:0033556 biolink:NamedThing dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity Catalysis of the addition of a glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(7)GlcNAc(2)-PP-Dol. got7fsn_ti dolichyl-P-Glc:Man7GlcNAc2-PP-dolichyl glucosyltransferase activity molecular_function owl:Class
GO:0098875 biolink:NamedThing epididymosome A microvesicle of the epididymal fluid, from which spermatozoa aquire membrane proteins. got7fsn_ti cellular_component owl:Class
GO:0034576 biolink:NamedThing N-isopropylacetanilide amidohydrolase activity Catalysis of the reaction: N-isopropylacetanilide + OH- = N-isopropylaniline + acetate. got7fsn_ti UM-BBD_reactionID:r0913 molecular_function owl:Class
GO:0033888 biolink:NamedThing chondro-6-sulfatase activity Catalysis of the reaction: 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine 6-sulfate + H(2)O = 4-deoxy-beta-D-gluc-4-enuronosyl-(1->3)-N-acetyl-D-galactosamine + H(+) + sulfate. got7fsn_ti 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity EC:3.1.6.10|MetaCyc:CHONDRO-6-SULFATASE-RXN|KEGG_REACTION:R03518|RHEA:10536 molecular_function owl:Class
GO:0016150 biolink:NamedThing translation release factor activity, codon nonspecific A translation release factor that is not specific to particular codons; binds to guanine nucleotides. got7fsn_ti molecular_function owl:Class
GO:0003885 biolink:NamedThing D-arabinono-1,4-lactone oxidase activity Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+). got7fsn_ti D-arabinono-1,4-lactone:oxygen oxidoreductase activity RHEA:23756|EC:1.1.3.37|KEGG_REACTION:R02715|MetaCyc:1.1.3.37-RXN molecular_function owl:Class
GO:0008788 biolink:NamedThing alpha,alpha-phosphotrehalase activity Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate. got7fsn_ti trehalose-6-phosphate hydrolase activity|phosphotrehalase activity|alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity EC:3.2.1.93|MetaCyc:TRE6PHYDRO-RXN|RHEA:23008 molecular_function owl:Class
GO:0005921 biolink:NamedThing gap junction A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins. got7fsn_ti macula communicans|zonula communicans|electrical synapse|gap junction macula|electrotonic synapse|gap junction plaque|intercellular gap junction channel|communicating junction NIF_Subcellular:sao118541872|Wikipedia:Gap_junction cellular_component owl:Class
GO:0075530 biolink:NamedThing establishment of latency as a linear episome A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure. got7fsn_ti establishment of linear plasmid latency|establishment of latency as a linear plasmid jl 2011-08-04T03:14:23Z biological_process owl:Class
GO:0047214 biolink:NamedThing cyanidin-3-rhamnosylglucoside 5-O-glucosyltransferase activity Catalysis of the reaction: cyanidin-3-O-D-rhamnosyl-(1,6)-D-glucoside + UDP-D-glucose = cyanidin-3-O-[D-rhamnosyl-(1,6)-D-glucoside]-5-O-D-glucoside + UDP. got7fsn_ti UDP-glucose:cyanidin-3-O-beta-L-rhamnosyl-(1->6)-beta-D-glucoside 5-O-beta-D-glucosyltransferase activity|UDP-glucose:cyanidin-3-O-D-rhamnosyl-1,6-D-glucoside 5-O-D-glucosyltransferase activity|cyanidin-3-O-rutinoside 5-O-glucosyltransferase activity|uridine diphosphoglucose-cyanidin 3-rhamnosylglucoside 5-O-glucosyltransferase activity RHEA:12144|MetaCyc:2.4.1.116-RXN|EC:2.4.1.116 molecular_function owl:Class
GO:0060941 biolink:NamedThing epicardium-derived cardiac fibroblast cell fate commitment The commitment of an epicardial cell to a cardiac fibroblast cell fate and its capacity to differentiate into a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules. got7fsn_ti dph 2009-09-29T01:44:36Z biological_process owl:Class
GO:0043427 biolink:NamedThing carbon fixation by 3-hydroxypropionate cycle An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product. got7fsn_ti 3-hydroxypropionate pathway|3-hydroxypropionate cycle|hydroxypropionate cycle|hydroxypropionate pathway biological_process owl:Class
GO:0061403 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions. got7fsn_ti dph 2012-01-10T03:15:30Z biological_process owl:Class
GO:0080108 biolink:NamedThing S-alkylthiohydroximate lyase activity Catalysis of the conversion of a S-alkylthiohydroximate to a thiohydroximate. got7fsn_ti S-alkylthiohydroximate C-S lyase activity dhl 2009-04-23T04:35:14Z molecular_function owl:Class
GO:0005731 biolink:NamedThing nucleolus organizer region A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed. got7fsn_ti NOR|nucleolus organiser region|nucleolus organizer complex Wikipedia:Nucleolus_organizer_region cellular_component owl:Class
GO:0044694 biolink:NamedThing pore-mediated entry of viral genome into host cell Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail. got7fsn_ti viral entry via genome injection|viral genome translocation|viral genome delivery via icosahedral vertex|viral pore-forming protein|pore-mediated penetration of viral genome into host cell|membrane puncture-mediated penetration of viral genome into host cell This mechanism is used by animal viruses such as poliovirus. Various tailed bacteriophages also carry specialized proteins which open a pore or a channel in the host membrane(s) to allow genome delivery into host cytoplasm. jl 2012-08-16T11:08:02Z VZ:979 biological_process owl:Class
GO:0002782 biolink:NamedThing antifungal peptide secretion The regulated release of an antifungal peptide from a cell or a tissue. got7fsn_ti biological_process owl:Class
GO:0097396 biolink:NamedThing response to interleukin-17 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus. got7fsn_ti response to IL-17 pr 2012-10-23T13:22:28Z biological_process owl:Class
GO:1990306 biolink:NamedThing RSP5-BUL ubiquitin ligase complex A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation. got7fsn_ti RSP5-BUL1 complex|RSP5-BUL2 complex This complex has been identified in Saccharomyces cerevisiae (P19812) - see PMID:9931424 bhm 2014-03-03T22:53:01Z cellular_component owl:Class
GO:0097748 biolink:NamedThing 3'-5' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end. got7fsn_ti pr 2016-12-02T11:51:31Z RHEA:57528 molecular_function owl:Class
GO:0009151 biolink:NamedThing purine deoxyribonucleotide metabolic process The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti purine deoxyribonucleotide metabolism biological_process owl:Class
GO:0001729 biolink:NamedThing ceramide kinase activity Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate. got7fsn_ti ATP:ceramide 1-phosphotransferase activity|acylsphingosine kinase activity EC:2.7.1.138|RHEA:17929|MetaCyc:CERAMIDE-KINASE-RXN|Reactome:R-HSA-1638845 molecular_function owl:Class
GO:0006188 biolink:NamedThing IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. got7fsn_ti IMP biosynthesis|IMP formation|IMP synthesis|IMP anabolism biological_process owl:Class
GO:0010742 biolink:NamedThing macrophage derived foam cell differentiation The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. got7fsn_ti biological_process owl:Class
GO:0043740 biolink:NamedThing GTP cyclohydrolase IIa activity Catalysis of the reaction: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H(+) + 2 phosphate. got7fsn_ti GTP cyclohydrolase III activity|GTP 8,9-dihydrolase (phosphate-forming)|GTP 8,9-hydrolase (phosphate-forming) RHEA:22468|MetaCyc:RXN-10055|EC:3.5.4.29|KEGG_REACTION:R07306 molecular_function owl:Class
GO:0061590 biolink:NamedThing calcium activated phosphatidylcholine scrambling The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. got7fsn_ti dph 2014-02-05T15:23:03Z biological_process owl:Class
GO:0008750 biolink:NamedThing NAD(P)+ transhydrogenase (AB-specific) activity Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+. got7fsn_ti pyridine nucleotide transhydrogenase activity|transhydrogenase activity|NAD(P) transhydrogenase (AB-specific) activity|NADPH:NAD+ oxidoreductase (AB-specific) MetaCyc:1.6.1.2-RXN|EC:1.6.1.2 molecular_function owl:Class
GO:0043784 biolink:NamedThing cob(II)yrinic acid a,c-diamide reductase activity Catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2). got7fsn_ti cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity RHEA:24300|EC:1.16.8.1|KEGG_REACTION:R05218|MetaCyc:R343-RXN molecular_function owl:Class
GO:0097086 biolink:NamedThing amniotic stem cell differentiation The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone. got7fsn_ti pr 2011-06-22T11:17:52Z biological_process owl:Class
GO:0031840 biolink:NamedThing type 2 neuromedin U receptor binding Binding to a type 2 neuromedin U receptor. got7fsn_ti type 2 neuromedin U receptor ligand molecular_function owl:Class
GO:0003843 biolink:NamedThing 1,3-beta-D-glucan synthase activity Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1). got7fsn_ti UDP-glucose-beta-glucan glucosyltransferase activity|(1,3)-beta-glucan (callose) synthase activity|1,3-beta-D-glucan synthetase activity|1,3-beta-glucan synthase activity|beta-1,3-glucan synthetase activity|callose synthetase activity|1,3-beta-D-glucan-UDP glucosyltransferase activity|1,3-beta-glucan-uridine diphosphoglucosyltransferase activity|UDPglucose-1,3-beta-D-glucan glucosyltransferase activity|UDP-glucose:(1,3)beta-glucan synthase activity|UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity|beta-1,3-glucan synthase activity|uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity|paramylon synthetase|GS-II|UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity|UDP-glucose-1,3-beta-glucan glucosyltransferase activity|callose synthase activity|UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity GO:0009981 EC:2.4.1.34|RHEA:21476|MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN molecular_function owl:Class
GO:0102844 biolink:NamedThing 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming) Catalysis of the reaction: 1-18:2-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor = 1-18:2-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.23|MetaCyc:RXN-8305 molecular_function owl:Class
GO:0103072 biolink:NamedThing straight chain (R)-2-hydroxy fatty acyl-CoA lyase activity Catalysis of the reaction: a (R)-2-hydroxy even numbered straight chain 2,3,4-saturated fatty acyl CoA = formyl-CoA + an odd numbered straight chain 2,3,4-saturated fatty aldehyde. got7fsn_ti MetaCyc:RXN66-475 molecular_function owl:Class
GO:0032130 biolink:NamedThing medial membrane band assembly The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring. got7fsn_ti medial membrane band formation biological_process owl:Class
GO:0047130 biolink:NamedThing saccharopine dehydrogenase (NADP+, L-lysine-forming) activity Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = 2-oxoglutarate + L-lysine + H(+) + NADPH. got7fsn_ti L-lysine-alpha-ketoglutarate reductase activity|lysine:alpha-ketoglutarate:TPNH oxidoreductase (epsilon-N-[gultaryl-2]-L-lysine forming)|6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)|saccharopine (nicotinamide adenine dinucleotide phosphate, lysine-forming) dehydrogenase activity GO:0010010 MetaCyc:1.5.1.8-RXN|RHEA:19373|Reactome:R-HSA-70938|EC:1.5.1.8|KEGG_REACTION:R00716 molecular_function owl:Class
GO:1900820 biolink:NamedThing orlandin catabolic process The chemical reactions and pathways resulting in the breakdown of orlandin. got7fsn_ti orlandin breakdown|orlandin degradation|orlandin catabolism di 2012-06-04T10:15:17Z biological_process owl:Class
GO:0071760 biolink:NamedThing IgY immunoglobulin complex A protein complex composed of two identical immunoglobulin heavy chains of the IgY isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgY immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. got7fsn_ti Note that an IgY immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Note that IgY is found in amphibians, reptiles, and birds. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0018936 biolink:NamedThing anaerobic nitrilotriacetate metabolic process The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen. got7fsn_ti anaerobic nitrilotriacetate metabolism biological_process owl:Class
GO:0002505 biolink:NamedThing antigen processing and presentation of polysaccharide antigen via MHC class II The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex. got7fsn_ti polysaccharide antigen processing and presentation via MHC class II biological_process owl:Class
GO:0070162 biolink:NamedThing adiponectin secretion The regulated release of adiponectin, a protein hormone, by adipose tissue. got7fsn_ti biological_process owl:Class
GO:0044228 biolink:NamedThing host cell surface The external part of the host cell wall and/or host plasma membrane. got7fsn_ti jl 2009-12-03T01:49:45Z cellular_component owl:Class
GO:0050481 biolink:NamedThing mandelate 4-monooxygenase activity Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O(2) = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H(2)O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate. got7fsn_ti mandelic acid 4-hydroxylase activity|L-mandelate 4-hydroxylase activity|(S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) EC:1.14.16.6|RHEA:21716|KEGG_REACTION:R03794|MetaCyc:MANDELATE-4-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0050153 biolink:NamedThing omega-hydroxydecanoate dehydrogenase activity Catalysis of the reaction: 10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH. got7fsn_ti 10-hydroxydecanoate:NAD+ 10-oxidoreductase activity|w-hydroxydecanoate dehydrogenase activity KEGG_REACTION:R03886|MetaCyc:OMEGA-HYDROXYDECANOATE-DEHYDROGENASE-RXN|RHEA:20880|EC:1.1.1.66 molecular_function owl:Class
GO:0047382 biolink:NamedThing methylphosphothioglycerate phosphatase activity Catalysis of the reaction: S-methyl-3-phospho-1-thio-D-glycerate + H(2)O = S-methyl-1-thio-D-glycerate + phosphate. got7fsn_ti S-methyl-3-phospho-1-thio-D-glycerate phosphohydrolase activity|methylthiophosphoglycerate phosphatase activity RHEA:16081|EC:3.1.3.14|MetaCyc:3.1.3.14-RXN|KEGG_REACTION:R04317 molecular_function owl:Class
GO:0021738 biolink:NamedThing fastigial nucleus development The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0047876 biolink:NamedThing endoglycosylceramidase activity Catalysis of the reaction: H2O + oligoglycosylglucosylceramide = ceramide + oligoglycosylglucose. got7fsn_ti oligoglycosylglucosylceramide glycohydrolase activity|EGCase activity|endo-glucosylceramidase activity|endoglycoceramidase activity|glycosyl-N-acetyl-sphingosine 1,1-beta-D-glucanohydrolase activity MetaCyc:ENDOGLYCOSYLCERAMIDASE-RXN|RHEA:22288|EC:3.2.1.123 molecular_function owl:Class
GO:0047893 biolink:NamedThing flavonol 3-O-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside. got7fsn_ti UDP-glucose:flavonol 3-O-glucosyltransferase activity|UDP-glucose:flavonol 3-O-D-glucosyltransferase activity|UDPglucose:flavonol 3-O-D-glucosyltransferase activity|UDPG:flavonoid-3-O-glucosyltransferase activity|UDP-glucose flavonol 3-O-glucosyltransferase activity|uridine diphosphoglucose-flavonol 3-O-glucosyltransferase activity|GTI MetaCyc:FLAVONOL-3-O-GLUCOSYLTRANSFERASE-RXN|EC:2.4.1.91|RHEA:22300 molecular_function owl:Class
GO:0102554 biolink:NamedThing lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein Catalysis of the reaction: 2 S-adenosyl-L-methionine + a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier]. got7fsn_ti MetaCyc:RXN-14959 molecular_function owl:Class
GO:0044689 biolink:NamedThing 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+. got7fsn_ti FO synthase jl 2012-08-15T14:33:17Z MetaCyc:RXN-8079|RHEA:27373|EC:2.5.1.147 molecular_function owl:Class
GO:0062239 biolink:NamedThing heterochromatin-nuclear membrane anchor activity Binding to heterochromatin and the nuclear inner membrane, in order to establish and maintain the heterochromatin location and organization. got7fsn_ti nuclear membrane-heterochromatin anchor activity|heterochromatin-nuclear membrane tether activity|nuclear membrane-heterochromatin tether activity dph 2020-04-20T18:20:36Z molecular_function owl:Class
GO:0050399 biolink:NamedThing xanthommatin reductase activity Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin. got7fsn_ti 5,12-dihydroxanthommatin:NAD+ oxidoreductase activity EC:1.3.1.41|RHEA:13417|KEGG_REACTION:R03787|MetaCyc:XANTHOMMATIN-REDUCTASE-RXN molecular_function owl:Class
GO:0097559 biolink:NamedThing right ventral flagellum A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc. got7fsn_ti right ventral cilium Note that we deem cilium and microtubule-based flagellum to be equivalent; the primary term name reflects frequency of use. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T13:28:20Z cellular_component owl:Class
GO:0061158 biolink:NamedThing 3'-UTR-mediated mRNA destabilization An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA. got7fsn_ti dph 2010-06-22T08:44:39Z biological_process owl:Class
GO:0004853 biolink:NamedThing uroporphyrinogen decarboxylase activity Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. got7fsn_ti porphyrinogen carboxy-lyase activity|porphyrinogen decarboxylase activity|uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)|uroporphyrinogen-III carboxy-lyase activity|uroporphyrinogen III decarboxylase activity Reactome:R-HSA-189425|Reactome:R-HSA-190182|MetaCyc:UROGENDECARBOX-RXN|RHEA:19865|EC:4.1.1.37 molecular_function owl:Class
GO:0106352 biolink:NamedThing aspartate dehydrogenase NADP activity Catalysis of the reaction: L-aspartate + H2O + NADP+ = oxaloacetate + NH3 + NADPH+ H+. got7fsn_ti hjd 2021-01-20T17:40:23Z RHEA:11784 molecular_function owl:Class
GO:0090391 biolink:NamedThing granum assembly A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts. got7fsn_ti grana formation tb 2010-12-08T04:25:46Z biological_process owl:Class
GO:0015679 biolink:NamedThing plasma membrane copper ion transport The directed movement of copper ions across the plasma membrane. got7fsn_ti plasma membrane copper transport biological_process owl:Class
GO:0070071 biolink:NamedThing proton-transporting two-sector ATPase complex assembly The aggregation, arrangement and bonding together of a proton-transporting two-sector ATPase complex, a large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. got7fsn_ti biological_process owl:Class
GO:0045054 biolink:NamedThing constitutive secretory pathway A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space. got7fsn_ti constitutive exocytosis biological_process owl:Class
GO:0019265 biolink:NamedThing glycine biosynthetic process, by transamination of glyoxylate The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate. got7fsn_ti glycine anabolism, by transamination of glyoxylate|glycine formation, by transamination of glyoxylate|glycine synthesis, by transamination of glyoxylate biological_process owl:Class
GO:0007439 biolink:NamedThing ectodermal digestive tract development The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm. got7fsn_ti ectodermal gut development biological_process owl:Class
GO:0103048 biolink:NamedThing tRNA m2A37 methyltransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + an adenine37 in tRNA <=> S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + a 2-methyladenine37 in tRNA. got7fsn_ti MetaCyc:RXN0-7007 molecular_function owl:Class
GO:0071834 biolink:NamedThing mating pheromone secretion The regulated release of a mating pheromone, a peptide hormone that induces a behavioral or physiological response(s) from a responding organism or cell, that contributes to a process of sexual reproduction. got7fsn_ti mating-type pheromone secretion mah 2010-09-09T11:22:35Z biological_process owl:Class
GO:0070156 biolink:NamedThing mitochondrial phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA in a mitochondrion, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. got7fsn_ti biological_process owl:Class
GO:0036399 biolink:NamedThing TCR signalosome assembly The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome. got7fsn_ti LAT signalosome assembly|linker for activation of T cells signalosome assembly bf 2013-07-18T14:02:53Z biological_process owl:Class
GO:0032098 biolink:NamedThing regulation of appetite Any process which modulates appetite, the desire or physical craving for food. got7fsn_ti regulation of hunger biological_process owl:Class
GO:0048403 biolink:NamedThing brain-derived neurotrophic factor binding Binding to brain-derived neurotrophic factor. got7fsn_ti BDNF binding|neurotrophin TRKB receptor activity molecular_function owl:Class
GO:0008983 biolink:NamedThing protein-glutamate O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester. got7fsn_ti protein carboxymethylase activity|methyl-accepting chemotaxis protein methyltransferase II|protein O-methyltransferase activity|protein carboxymethyltransferase activity|protein carboxyl-O-methyltransferase activity|methyl-accepting chemotaxis protein O-methyltransferase activity|S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity|protein(carboxyl)methyltransferase activity|MCP methyltransferase I|protein carboxylmethyltransferase II|protein carboxyl-methylase activity|protein(aspartate)methyltransferase activity|S-adenosylmethionine-glutamyl methyltransferase activity|MCP methyltransferase II|S-adenosylmethionine:protein-carboxyl O-methyltransferase activity|protein methylase II RESID:AA0072|MetaCyc:CHER-RXN|RHEA:24452|EC:2.1.1.80 molecular_function owl:Class
GO:0002373 biolink:NamedThing plasmacytoid dendritic cell cytokine production Any process that contributes to cytokine production by a plasmacytoid dendritic cell. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:1990429 biolink:NamedThing peroxisomal importomer complex A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners. got7fsn_ti peroxisomal protein import machinery|peroxisomal import pore|Pex14 complex jl 2014-07-29T14:45:28Z cellular_component owl:Class
GO:0046451 biolink:NamedThing diaminopimelate metabolic process The chemical reactions and pathways involving diaminopimelate, the anion of the dicarboxylic acid 2,6-diaminoheptanedioic acid. It is an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. got7fsn_ti diaminopimelate metabolism biological_process owl:Class
GO:0010491 biolink:NamedThing UTP:arabinose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate. got7fsn_ti molecular_function owl:Class
GO:0043308 biolink:NamedThing eosinophil degranulation The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil. got7fsn_ti eosinophil granule exocytosis biological_process owl:Class
GO:0035479 biolink:NamedThing angioblast cell migration from lateral mesoderm to midline The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature. got7fsn_ti bf 2010-04-23T10:38:05Z biological_process owl:Class
GO:0097257 biolink:NamedThing leukotriene B4 12-hydroxy dehydrogenase activity Catalysis of the reaction: leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+). got7fsn_ti leukotriene B4 12-hydroxydehydrogenase activity pr 2012-03-07T02:07:41Z RHEA:50608|Reactome:R-HSA-2161567 molecular_function owl:Class
GO:0120185 biolink:NamedThing MBF transcription complex assembly The aggregation, arrangement and bonding together of a set of components to form an MBF transcription complex. got7fsn_ti DSC1 transcription factor complex assembly|MBF complex assembly|Mlu1-box binding factor assembly krc 2018-07-13T23:21:43Z biological_process owl:Class
GO:0047247 biolink:NamedThing luteolin-7-O-diglucuronide 4'-O-glucuronosyltransferase activity Catalysis of the reaction: luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] + UDP-alpha-D-glucuronate = H(+) + luteolin 7-O-[(beta-D-glucosiduronate)-(1->2)-(beta-D-glucosiduronate)] 4'-O-beta-D-glucosiduronate + UDP. got7fsn_ti UDP-glucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity|UDP-glucuronate:luteolin 7-O-diglucuronide-glucuronosyltransferase activity|LDT|UDPglucuronate:luteolin-7-O-beta-D-diglucuronide 4'-O-glucuronosyltransferase activity|UDPglucuronate:luteolin 7-O-diglucuronide-4'-O-glucuronosyl-transferase activity|uridine diphosphoglucuronate-luteolin 7-O-diglucuronide glucuronosyltransferase activity EC:2.4.1.191|MetaCyc:2.4.1.191-RXN|KEGG_REACTION:R06828|RHEA:22116 molecular_function owl:Class
GO:0008980 biolink:NamedThing propionate kinase activity Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate. got7fsn_ti PduW|propanoate kinase activity|ATP:propanoate phosphotransferase activity|TdcD EC:2.7.2.15|RHEA:23148 molecular_function owl:Class
GO:0106376 biolink:NamedThing 2-hydroxyphytanoyl-CoA lyase activity Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA. got7fsn_ti hjd 2021-04-16T12:47:53Z RHEA:25355 molecular_function owl:Class
GO:0004125 biolink:NamedThing L-seryl-tRNASec selenium transferase activity Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate. got7fsn_ti cysteinyl-tRNA(Sec)-selenium transferase activity|L-seryl-tRNA(Ser) selenium transferase activity|L-selenocysteinyl-tRNASec synthase activity|cysteinyl-tRNASec-selenium transferase activity|selenocysteinyl-tRNA(Ser) synthase activity|selenophosphate:L-seryl-tRNASec selenium transferase activity|cysteinyl-tRNA(Ser) selenium transferase activity|cysteinyl-tRNA(Sel)-selenium transferase activity|L-selenocysteinyl-tRNA(Sel) synthase activity|selenocysteine synthase activity|L-selenocysteinyl-tRNASel synthase activity|cysteinyl-tRNASel-selenium transferase activity|L-selenocysteinyl-tRNA(Sec) synthase activity MetaCyc:2.9.1.1-RXN|RHEA:22728|EC:2.9.1.1 molecular_function owl:Class
GO:0047298 biolink:NamedThing (S)-3-amino-2-methylpropionate transaminase activity Catalysis of the reaction: (S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate. got7fsn_ti (S)-3-amino-2-methylpropanoate:2-oxoglutarate aminotransferase activity|beta-aminoisobutyrate-alpha-ketoglutarate transaminase activity|L-3-aminoisobutyrate transaminase activity|(S)-3-amino-2-methylpropionate aminotransferase activity|L-3-aminoisobutyric aminotransferase activity|L-3-aminoisobutyrate aminotransferase activity|beta-aminobutyric transaminase activity|L-AIBAT activity MetaCyc:2.6.1.22-RXN|RHEA:13993|EC:2.6.1.22|KEGG_REACTION:R04188 molecular_function owl:Class
GO:0004106 biolink:NamedThing chorismate mutase activity Catalysis of the reaction: chorismate = prephenate. got7fsn_ti chorismate pyruvatemutase activity|hydroxyphenylpyruvate synthase activity RHEA:13897|EC:5.4.99.5|MetaCyc:CHORISMATEMUT-RXN|KEGG_REACTION:R01715 molecular_function owl:Class
GO:0033969 biolink:NamedThing gamma-glutamyl-gamma-aminobutyrate hydrolase activity Catalysis of the reaction: 4-(L-gamma-glutamylamino)butanoate + H(2)O = 4-aminobutanoate + L-glutamate. got7fsn_ti gamma-glutamyl-GABA hydrolase activity|PuuD|YcjL|4-(glutamylamino)butanoate amidohydrolase activity KEGG_REACTION:R07419|MetaCyc:RXN0-3942|EC:3.5.1.94|RHEA:19737 molecular_function owl:Class
GO:0047556 biolink:NamedThing 3,4-dihydroxyphthalate decarboxylase activity Catalysis of the reaction: 3,4-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO(2). got7fsn_ti 3,4-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)|3,4-dihydroxyphthalate carboxy-lyase activity|3,4-dihydroxyphthalate 2-decarboxylase activity GO:0034913 RHEA:18601|UM-BBD_reactionID:r1447|MetaCyc:34-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN|EC:4.1.1.69|KEGG_REACTION:R01634 molecular_function owl:Class
GO:0004775 biolink:NamedThing succinate-CoA ligase (ADP-forming) activity Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. got7fsn_ti succinyl coenzyme A synthetase|succinic thiokinase|succinyl-CoA synthetase (ADP-forming) activity|succinyl-CoA synthetase activity|succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity|succinate thiokinase activity|A-STK (adenin nucleotide-linked succinate thiokinase)|A-SCS|succinate:CoA ligase (ADP-forming) activity EC:6.2.1.5|KEGG_REACTION:R00405|MetaCyc:SUCCCOASYN-RXN|Reactome:R-HSA-70997|RHEA:17661 molecular_function owl:Class
GO:0050683 biolink:NamedThing AF-1 domain binding Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor. got7fsn_ti molecular_function owl:Class
GO:0005148 biolink:NamedThing prolactin receptor binding Binding to a prolactin receptor. got7fsn_ti prolactin receptor ligand|prolactin molecular_function owl:Class
GO:0051885 biolink:NamedThing positive regulation of timing of anagen Any process that activates or increases the frequency, rate or extent of timing of anagen, the growth phase of the hair cycle. got7fsn_ti up-regulation of anagen|stimulation of anagen|up regulation of anagen|positive regulation of anagen|upregulation of anagen|activation of anagen biological_process owl:Class
GO:0051581 biolink:NamedThing negative regulation of neurotransmitter uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. got7fsn_ti negative regulation of neurotransmitter import|down-regulation of neurotransmitter uptake|downregulation of neurotransmitter uptake|down regulation of neurotransmitter uptake biological_process owl:Class
GO:0033867 biolink:NamedThing Fas-activated serine/threonine kinase activity Catalysis of the reaction: ATP + Fas-activated serine/threonine protein = ADP + Fas-activated serine/threonine phosphoprotein. got7fsn_ti FASTK|ATP:Fas-activated serine/threonine protein phosphotransferase activity|STK10|FAST EC:2.7.11.8|MetaCyc:2.7.11.8-RXN molecular_function owl:Class
GO:0050088 biolink:NamedThing mannose-6-phosphate 6-reductase activity Catalysis of the reaction: D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + 3 H(+) + NADPH. got7fsn_ti NADPH-dependent mannose 6-phosphate reductase activity|NADPH-mannose-6-P reductase activity|NADPH-dependent M6P reductase activity|NADP-dependent mannose-6-P:mannitol-1-P oxidoreductase activity|mannose-6-phosphate reductase activity|D-mannitol-1-phosphate:NADP+ 6-oxidoreductase activity|6-phosphomannose reductase activity KEGG_REACTION:R01817|MetaCyc:MANNOSE-6-PHOSPHATE-6-REDUCTASE-RXN|RHEA:14925|EC:1.1.1.224 molecular_function owl:Class
GO:0005914 biolink:NamedThing spot adherens junction A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens. got7fsn_ti punctum adherens|dense plaque cellular_component owl:Class
GO:0072101 biolink:NamedThing specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis. got7fsn_ti specification of ureteric bud anterior/posterior asymmetry by BMP signaling pathway|specification of ureteric bud anterior/posterior symmetry by BMP signalling pathway mah 2010-02-10T02:21:03Z biological_process owl:Class
GO:1901719 biolink:NamedThing regulation of NMS complex assembly Any process that modulates the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation. got7fsn_ti regulation of KMN network assembly involved in chromosome segregation|regulation of NMS complex assembly involved in kinetochore assembly|regulation of KMN complex assembly involved in chromosome segregation|regulation of NMS complex association involved in chromosome segregation jl 2012-12-20T11:44:17Z biological_process owl:Class
GO:0090234 biolink:NamedThing regulation of kinetochore assembly Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. got7fsn_ti regulation of chromosome-kinetochore attachment tb 2010-01-20T10:46:56Z biological_process owl:Class
GO:0099153 biolink:NamedThing synaptic transmission, serotonergic The vesicular release of serotonin from a presynapse, across a chemical synapse, the subsequent activation of serotonin receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. got7fsn_ti serotonergic synaptic transmission dos 2017-07-05T14:16:51Z biological_process owl:Class
GO:0047109 biolink:NamedThing (S)-3-hydroxyacid-ester dehydrogenase activity Catalysis of the reaction: ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH. got7fsn_ti (S)-3-hydroxyacid ester dehydrogenase activity|ethyl-(S)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity|3-oxo ester (S)-reductase activity Note that this term was EC:1.2.1.56. EC:1.1.1.280|KEGG_REACTION:R04106|MetaCyc:1.2.1.56-RXN|RHEA:18269 molecular_function owl:Class
GO:0051396 biolink:NamedThing positive regulation of nerve growth factor receptor activity Any process that activates or increases the frequency, rate or extent of the activity of the nerve growth factor (NGF) receptor. got7fsn_ti stimulation of nerve growth factor receptor activity|up-regulation of nerve growth factor receptor activity|activation of nerve growth factor receptor activity|positive regulation of NGF receptor activity|up regulation of nerve growth factor receptor activity|upregulation of nerve growth factor receptor activity biological_process owl:Class
GO:0050567 biolink:NamedThing glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP. got7fsn_ti glutaminyl-tRNA synthase (glutamine-hydrolysing)|glutamyl-tRNA(Gln) amidotransferase activity|Glu-tRNA(Gln) amidotransferase activity|Glu-AdT activity|glutamyl-tRNAGln:L-glutamine amido-ligase (ADP-forming)|Glu-tRNAGln:L-glutamine amido-ligase (ADP-forming)|glutamyl-tRNAGln amidotransferase activity|Glu-tRNAGln amidotransferase activity GO:0008264|GO:0017068 MetaCyc:6.3.5.7-RXN|RHEA:17521|Wikipedia:Glutaminyl-tRNA_synthase_(glutamine-hydrolysing)|EC:6.3.5.7 molecular_function owl:Class
GO:0001869 biolink:NamedThing negative regulation of complement activation, lectin pathway Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway. got7fsn_ti negative regulation of complement cascade, lectin pathway|down regulation of complement activation, lectin pathway|down-regulation of complement activation, lectin pathway|downregulation of complement activation, lectin pathway|inhibition of complement activation, lectin pathway biological_process owl:Class
GO:0004155 biolink:NamedThing 6,7-dihydropteridine reductase activity Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine. got7fsn_ti dihydropteridine reduction|6,7-dihydropteridine:NAD(P)H oxidoreductase activity|5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity|NADH-dihydropteridine reductase activity|NADPH-specific dihydropteridine reductase activity|NAD(P)H2:6,7-dihydropteridine oxidoreductase activity|dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity|dihydropteridine reductase (NADH) activity|dihydropteridine reductase activity|NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity|5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity|DHPR activity|NADPH-dihydropteridine reductase activity Note that this function was formerly EC:1.6.99.7. MetaCyc:1.5.1.34-RXN|Reactome:R-HSA-71130|EC:1.5.1.34 molecular_function owl:Class
GO:0004401 biolink:NamedThing histidinol-phosphatase activity Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate. got7fsn_ti L-histidinol phosphate phosphatase activity|histidinolphosphate phosphatase activity|histidinolphosphatase activity|HPpase activity|L-histidinol-phosphate phosphohydrolase activity|histidinol phosphate phosphatase activity MetaCyc:HISTIDPHOS-RXN|KEGG_REACTION:R03013|EC:3.1.3.15|RHEA:14465 molecular_function owl:Class
GO:0052168 biolink:NamedThing modulation by symbiont of defense-related host calcium-dependent protein kinase pathway Any process in which an organism modulates the frequency, rate or extent of the host calcium-dependent protein kinase signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of defense-related calcium-dependent protein kinase pathway in other organism involved in symbiotic interaction|modulation by organism of defense-related host CDPK pathway GO:0052307 biological_process owl:Class
GO:0008446 biolink:NamedThing GDP-mannose 4,6-dehydratase activity Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O. got7fsn_ti GDP-mannose 4,6-hydro-lyase activity|guanosine 5'-diphosphate-D-mannose oxidoreductase activity|GDP-D-mannose dehydratase activity|guanosine diphosphomannose 4,6-dehydratase activity|GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)|GDPmannose 4,6-dehydratase activity|Gmd|guanosine diphosphomannose oxidoreductase activity|GDP-D-mannose 4,6-dehydratase activity EC:4.2.1.47|MetaCyc:GDPMANDEHYDRA-RXN|RHEA:23820|KEGG_REACTION:R00888|Reactome:R-HSA-6787632 molecular_function owl:Class
GO:0032626 biolink:NamedThing interleukin-22 production The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti ZCYTO18 production|ILTIF production|IL-22 production|IL22 production|interleukin-22 secretion|interleukin-22 biosynthetic process GO:0042239|GO:0072620 biological_process owl:Class
GO:0004118 biolink:NamedThing cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP. got7fsn_ti molecular_function owl:Class
GO:0031768 biolink:NamedThing ghrelin receptor binding Binding to a ghrelin receptor. got7fsn_ti ghrelin receptor ligand|type 1 growth hormone secretagogue GH-releasing peptide receptor binding molecular_function owl:Class
GO:1990599 biolink:NamedThing 3' overhang single-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks. got7fsn_ti al 2015-01-06T15:21:28Z molecular_function owl:Class
GO:0000014 biolink:NamedThing single-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. got7fsn_ti ssDNA-specific endodeoxyribonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity molecular_function owl:Class
GO:0050596 biolink:NamedThing vinorine hydroxylase activity Catalysis of the reaction: H(+) + NADPH + O(2) + vinorine = H(2)O + NADP(+) + vomilenine. got7fsn_ti vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating) MetaCyc:1.14.13.75-RXN|EC:1.14.14.104|RHEA:17257|KEGG_REACTION:R05877 molecular_function owl:Class
GO:0018739 biolink:NamedThing 4-hydroxybenzoyl-CoA thioesterase activity Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+). got7fsn_ti 4-hydroxybenzoyl-CoA hydrolase activity|4-hydroxybenzoyl-CoA thiolesterase activity KEGG_REACTION:R01301|UM-BBD_reactionID:r0141|MetaCyc:3.1.2.23-RXN|RHEA:11948|EC:3.1.2.23 molecular_function owl:Class
GO:0047954 biolink:NamedThing glycerol-2-phosphatase activity Catalysis of the reaction: glycerol 2-phosphate + H(2)O = glycerol + phosphate. got7fsn_ti glycerol-2-phosphate phosphohydrolase activity|beta-glycerophosphate phosphatase activity|beta-glycerophosphatase activity|2-glycerophosphatase activity EC:3.1.3.19|MetaCyc:GLYCEROL-2-PHOSPHATASE-RXN|KEGG_REACTION:R01043|RHEA:13105 molecular_function owl:Class
GO:0052909 biolink:NamedThing 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA. got7fsn_ti M(6)(2)A dimethylase activity https://github.com/geneontology/go-ontology/issues/14459 EC:2.1.1.183|MetaCyc:RXN-11634|RHEA:42780 molecular_function owl:Class
GO:0140032 biolink:NamedThing glycosylation-dependent protein binding Binding to a protein upon glycosylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require glycosylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of glycosylation. It may be that the glycosylation causes a conformational change that allows binding of the protein to another region; this type of glycosylation-dependent protein binding is valid for annotation to this term. pg 2017-05-17T15:20:50Z molecular_function owl:Class
GO:0033458 biolink:NamedThing GAC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GAC codon. got7fsn_ti aspartic acid tRNA Note that in the standard genetic code, GAC codes for aspartic acid. molecular_function owl:Class
GO:0008114 biolink:NamedThing phosphogluconate 2-dehydrogenase activity Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH. got7fsn_ti 6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity|6-phosphogluconate dehydrogenase (NAD)|6-phosphogluconate 2-dehydrogenase activity|2-keto-6-phosphogluconate reductase activity|phosphogluconate dehydrogenase activity|gluconate 6-phosphate dehydrogenase activity|6-phosphogluconic dehydrogenase activity MetaCyc:1.1.1.43-RXN|EC:1.1.1.43 molecular_function owl:Class
GO:0047343 biolink:NamedThing glucose-1-phosphate cytidylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + CTP = CDP-D-glucose + diphosphate. got7fsn_ti CTP:alpha-D-glucose-1-phosphate cytidylyltransferase activity|CDP glucose pyrophosphorylase activity|CDP-glucose diphosphorylase activity|CTP:glucose-1-phosphate cytidylyltransferase activity|CTP:D-glucose-1-phosphate cytidylyltransferase activity|CDP-glucose pyrophosphorylase activity|cytidine diphosphoglucose pyrophosphorylase activity|cytidine diphosphate-D-glucose pyrophosphorylase activity|cytidine diphosphate glucose pyrophosphorylase activity MetaCyc:2.7.7.33-RXN|EC:2.7.7.33|KEGG_REACTION:R00956|RHEA:18213 molecular_function owl:Class
GO:0010814 biolink:NamedThing substance P catabolic process The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P. got7fsn_ti biological_process owl:Class
GO:0018675 biolink:NamedThing (S)-limonene 6-monooxygenase activity Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O. got7fsn_ti limonene 6-hydroxylase activity|(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity|(-)-limonene 6-hydroxylase activity|(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)|(-)-limonene 6-monooxygenase activity UM-BBD_reactionID:r0713|EC:1.14.14.51|RHEA:17945|MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0015608 biolink:NamedThing carbohydrate-importing ABC transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in). got7fsn_ti sugar transporter|carbohydrate uptake transporter activity|carbohydrate-importing ATPase activity https://github.com/geneontology/go-ontology/issues/17289 TC:3.A.1.1.1 molecular_function owl:Class
GO:0070561 biolink:NamedThing vitamin D receptor signaling pathway The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands. got7fsn_ti VDR signaling pathway|calcitriol signaling pathway|vitamin D receptor signalling pathway mah 2009-04-14T01:43:59Z biological_process owl:Class
GO:0052621 biolink:NamedThing diguanylate cyclase activity Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H(+). got7fsn_ti GTP:GTP guanylyltransferase activity GO:0043789 EC:2.7.7.65|RHEA:24898|MetaCyc:RXN0-5359|KEGG_REACTION:R08057 molecular_function owl:Class
GO:0051654 biolink:NamedThing establishment of mitochondrion localization The directed movement of the mitochondrion to a specific location. got7fsn_ti establishment of mitochondrion localisation|establishment of mitochondria localization|mitochondrial migration|mitochondria positioning|mitochondrion positioning biological_process owl:Class
GO:0000474 biolink:NamedThing maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. got7fsn_ti biological_process owl:Class
GO:0140421 biolink:NamedThing endocytic heme import into cell The directed movement into cell of externally available heme by receptor-mediated endocytosis. got7fsn_ti heme assimilation https://github.com/geneontology/go-ontology/issues/18671 pg 2020-01-30T13:14:02Z biological_process owl:Class
GO:0098657 biolink:NamedThing import into cell The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis. got7fsn_ti uptake biological_process owl:Class
GO:0022859 biolink:NamedThing dephosphorylation-gated channel activity Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts. got7fsn_ti molecular_function owl:Class
GO:0061328 biolink:NamedThing posterior Malpighian tubule development The process whose specific outcome is the progression of the posterior Malpighian tubule over time, from its formation to the mature structure. The pair of posterior tubules arise from a ventrolateral region of the embryonic hindgut and project backwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut. got7fsn_ti dph 2010-09-28T01:24:35Z biological_process owl:Class
GO:1990114 biolink:NamedThing RNA polymerase II core complex assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex. got7fsn_ti RNA Polymerase II assembly|DNA-directed RNA polymerase II, core complex assembly rb 2013-05-31T21:46:42Z biological_process owl:Class
GO:0046653 biolink:NamedThing tetrahydrofolate metabolic process The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group. got7fsn_ti tetrahydrofolate metabolism biological_process owl:Class
GO:0061172 biolink:NamedThing regulation of establishment of bipolar cell polarity Any process that modulates the rate, frequency or extent of the establishment of bipolar cell polarity. Bipolar organization is the organization that is a mirror image along an axis from a plane. got7fsn_ti dph 2010-06-30T08:51:27Z biological_process owl:Class
GO:0034892 biolink:NamedThing endosulfan lactone lactonase activity Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+. got7fsn_ti UM-BBD_reactionID:r1389 molecular_function owl:Class
GO:0030763 biolink:NamedThing isobutyraldoxime O-methyltransferase activity Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosylmethionine:aldoxime O-methyltransferase activity|aldoxime methyltransferase activity|aldoxime O-methyltransferase activity|S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity RHEA:10996|EC:2.1.1.91|KEGG_REACTION:R04169|MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN molecular_function owl:Class
GO:0034568 biolink:NamedThing isoproturon dimethylaminedehydrogenase activity Catalysis of the reaction: isoproturon + H2O = formaldehyde + monodemethylisoproturon + 2 H+ + 2 e-. got7fsn_ti EC:1.5.99.-|UM-BBD_reactionID:r0892 molecular_function owl:Class
GO:0050081 biolink:NamedThing maltose-6'-phosphate glucosidase activity Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate. got7fsn_ti phospho-alpha-glucosidase activity|maltose-6'-phosphate 6-phosphoglucohydrolase activity EC:3.2.1.122|MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN|RHEA:20421 molecular_function owl:Class
GO:0030603 biolink:NamedThing oxaloacetase activity Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate. got7fsn_ti oxaloacetate acetylhydrolase activity|oxalacetic hydrolase activity MetaCyc:OXALOACETASE-RXN|EC:3.7.1.1|RHEA:24432|KEGG_REACTION:R00338 molecular_function owl:Class
GO:0035818 biolink:NamedThing positive regulation of urine volume by pressure natriuresis An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis. got7fsn_ti diuresis resulting from pressure natriuresis bf 2011-04-20T01:55:42Z biological_process owl:Class
GO:0102895 biolink:NamedThing colneleate synthase activity Catalysis of the reaction: 9(S)-HPODE <=> colneleate + H2O. got7fsn_ti MetaCyc:RXN-8496|EC:4.2.1.121|RHEA:28174 molecular_function owl:Class
GO:0090415 biolink:NamedThing 7-hydroxymethyl chlorophyll a reductase activity Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O. got7fsn_ti tb 2011-10-03T12:08:27Z molecular_function owl:Class
GO:0052592 biolink:NamedThing oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. got7fsn_ti oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulphur protein as acceptor EC:1.17.7.- molecular_function owl:Class
GO:0044220 biolink:NamedThing host cell perinuclear region of cytoplasm The host cell cytoplasm situated near, or occurring around, the host nucleus. got7fsn_ti jl 2009-11-12T02:58:13Z cellular_component owl:Class
GO:0015046 biolink:NamedThing rubredoxin-NADP+ reductase activity Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+. got7fsn_ti EC:1.18.1.4|RHEA:13949 molecular_function owl:Class
GO:0006855 biolink:NamedThing xenobiotic transmembrane transport The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti drug transmembrane transport|multidrug transport|drug membrane transport https://github.com/geneontology/go-ontology/issues/19460 Note that this term is not intended for use in annotating lateral movement within membranes. biological_process owl:Class
GO:0034978 biolink:NamedThing PDX1-PBX1b-MRG1 complex A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes. got7fsn_ti acinar cell-specific C complex cellular_component owl:Class
GO:0047255 biolink:NamedThing galactogen 6-beta-galactosyltransferase activity Catalysis of the reaction: galactogen + UDP-galactose = 1,6-beta-D-galctosylgalactogen + UDP. got7fsn_ti galactogen 6beta-galactosyltransferase activity|uridine diphosphogalactose-galactogen galactosyltransferase activity|1,6-D-galactosyltransferase activity|beta-(1,6)-D-galactosyltransferase activity|UDP-galactose:galactogen beta-1,6-D-galactosyltransferase activity|UDPgalactose:galactogen beta-1,6-D-galactosyltransferase activity EC:2.4.1.205|MetaCyc:2.4.1.205-RXN molecular_function owl:Class
GO:1900811 biolink:NamedThing helvolic acid catabolic process The chemical reactions and pathways resulting in the breakdown of helvolic acid. got7fsn_ti Fumigacin degradation|helvolic acid breakdown|Fumigacin catabolism|helvolic acid catabolism|Fumigacin catabolic process|Fumigacin breakdown|helvolic acid degradation di 2012-06-04T10:02:51Z biological_process owl:Class
GO:0000334 biolink:NamedThing 3-hydroxyanthranilate 3,4-dioxygenase activity Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+). got7fsn_ti 3HAO|3-hydroxyanthranilate oxygenase activity|3-hydroxyanthranilic acid oxygenase activity|3-hydroxyanthranilic acid dioxygenase activity|3-hydroxyanthranilic oxygenase activity|3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing) EC:1.13.11.6|KEGG_REACTION:R02665|RHEA:17953|UM-BBD_reactionID:r1027|MetaCyc:1.13.11.6-RXN|Reactome:R-HSA-71218 molecular_function owl:Class
GO:0031741 biolink:NamedThing type B gastrin/cholecystokinin receptor binding Binding to a type B gastrin/cholecystokinin receptor. got7fsn_ti type B gastrin/cholecystokinin receptor ligand molecular_function owl:Class
GO:1990956 biolink:NamedThing fibroblast chemotaxis The directed movement of a fibroblast guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). got7fsn_ti dph 2016-06-02T19:54:19Z biological_process owl:Class
GO:0010031 biolink:NamedThing circumnutation The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth. got7fsn_ti biological_process owl:Class
GO:0036006 biolink:NamedThing cellular response to macrophage colony-stimulating factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. got7fsn_ti cellular response to M-CSF stimulus|cellular response to macrophage colony-stimulating factor bf 2011-09-20T04:23:19Z biological_process owl:Class
GO:0070817 biolink:NamedThing P-TEFb-cap methyltransferase complex localization Any process in which the P-TEFb-cap methyltransferase complex is transported to, or maintained in, a specific location. got7fsn_ti P-TEFb-cap methyltransferase complex localisation|establishment and maintenance of P-TEFb-cap methyltransferase complex localization mah 2009-07-13T04:20:17Z biological_process owl:Class
GO:0005278 biolink:NamedThing acetylcholine:proton antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out). got7fsn_ti acetylcholine:hydrogen antiporter activity molecular_function owl:Class
GO:0052773 biolink:NamedThing diacetylchitobiose deacetylase activity Catalysis of the reaction: N,N'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc). got7fsn_ti N,N'-diacetylchitobiose deacetylase (nonreducing end) In this reaction N,N'-diacetylchitobiose is deacetylated at the non-reducing residue to produce 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc). This is in contrast to EC:3.5.1.105 in which N,N'-diacetylchitobiose is deacetylated at the reducing residue to produce 4-O-(N-acetyl-beta-D-glucosaminyl)-D-glucosamine (GlcNAc-GlcN). For the latter reaction, see GO:0036311. ai 2011-10-03T12:01:05Z MetaCyc:RXN-12543 molecular_function owl:Class
GO:0035230 biolink:NamedThing cytoneme A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um. got7fsn_ti membrane nanotube Wikipedia:Membrane_nanotube cellular_component owl:Class
GO:0018762 biolink:NamedThing aliphatic nitrilase activity Catalysis of the reaction: R-CN + H2O = R-COOH + NH3. got7fsn_ti aliphatic nitrile aminohydrolase activity RHEA:46188|UM-BBD_reactionID:r0622|EC:3.5.5.7|MetaCyc:3.5.5.7-RXN molecular_function owl:Class
GO:2001031 biolink:NamedThing positive regulation of cellular glucuronidation Any process that activates or increases the frequency, rate or extent of cellular glucuronidation. got7fsn_ti positive regulation of cellular glucuronoside biosynthesis|positive regulation of cellular glucuronoside biosynthetic process|positive regulation of cellular glucuronide biosynthesis|positive regulation of cellular glucuronide biosynthetic process rl 2011-08-22T01:10:59Z biological_process owl:Class
GO:0102334 biolink:NamedThing N,N'-diacetylbacilliosaminyl-1-phosphate transferase activity Catalysis of the reaction: ditrans,polycis-undecaprenyl phosphate + UDP-N,N'-diacetylbacillosamine <=> N,N'-diacetyl-alpha-D-bacillosaminyl-diphospho-tri-trans,hepta-cis-undecaprenol + UMP. got7fsn_ti MetaCyc:RXN-13269|RHEA:34515|EC:2.7.8.36 molecular_function owl:Class
GO:0140701 biolink:NamedThing 3',3'-cyclic GMP-AMP synthase activity Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic G-P(3'-5')A-P(3'-5') (cyclic 3',3' GAMP). got7fsn_ti 3',3'-cyclic GAMP synthase activity|3',3' cyclic-GMP-AMP synthase activity|3',3' cyclic-GAMP synthase activity https://github.com/geneontology/go-ontology/issues/21980 pg 2021-08-27T05:13:09Z RHEA:35647 molecular_function owl:Class
GO:0042163 biolink:NamedThing interleukin-12 beta subunit binding Binding to the beta subunit of interleukin-12. got7fsn_ti NKSFp40 binding|IL-12B binding|CLMFp40 binding|IL-12p40 binding molecular_function owl:Class
GO:0090038 biolink:NamedThing negative regulation of protein kinase C signaling Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. got7fsn_ti negative regulation of protein kinase C signaling cascade|negative regulation of protein kinase C signalling cascade tb 2009-08-03T11:29:33Z biological_process owl:Class
GO:0102465 biolink:NamedThing zeaxanthin 2,2'-beta-hydroxylase activity Catalysis of the reaction: zeaxanthin + 2 NADH + 2 H+ + 2 O2 <=> nostoxanthin + 2 NAD + 2 H2O. got7fsn_ti MetaCyc:RXN-14018 molecular_function owl:Class
GO:0050406 biolink:NamedThing [acetyl-CoA carboxylase]-phosphatase activity Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate. got7fsn_ti acetyl-CoA:carbon-dioxide ligase (ADP-forming)-phosphate phosphohydrolase activity|acetyl-CoA carboxylase-phosphatase activity RHEA:17125|EC:3.1.3.44|MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN molecular_function owl:Class
GO:0140595 biolink:NamedThing MIM complex A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. MIM constitutes the major integration site for alpha-helical embedded proteins. In yeast, consists oof Mim1 and Mim2. got7fsn_ti mitochondrial outer import machinery https://github.com/geneontology/go-ontology/issues/20669 pg 2021-02-09T19:34:16Z cellular_component owl:Class
GO:0090268 biolink:NamedThing activation of mitotic cell cycle spindle assembly checkpoint Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint. got7fsn_ti tb 2010-02-05T02:09:44Z biological_process owl:Class
GO:0034102 biolink:NamedThing erythrocyte clearance The selective elimination of erythrocytes from the body by autoregulatory mechanisms. got7fsn_ti neocytolysis|red blood cell clearance|RBC clearance Note that this term is intended for annotation of self-gene products that lead to elimination of erythrocytes without the involvement of a symbiont. biological_process owl:Class
GO:0102356 biolink:NamedThing isoitalicene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + (+)-isoitalicene. got7fsn_ti MetaCyc:RXN-13373 molecular_function owl:Class
GO:0031040 biolink:NamedThing micronucleus A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell. got7fsn_ti Wikipedia:Micronucleus cellular_component owl:Class
GO:0052079 biolink:NamedThing induction by symbiont of defense-related host MAP kinase-mediated signal transduction pathway Any process in which an organism activates, maintains or increases the frequency, rate or extent of a host MAP kinase-mediated signal transduction pathway during the host innate immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti upregulation by organism of defense-related host MAP kinase-mediated signal transduction pathway|activation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|induction by organism of defense-related host MAP kinase-mediated signal transduction pathway|upregulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|stimulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|activation by organism of defense-related host MAP kinase-mediated signal transduction pathway|positive regulation by organism of defense-related MAP kinase-mediated signal transduction pathway in other organism involved in symbiotic interaction|up regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|positive regulation by organism of defense-related host mitogen-activated protein kinase-mediated signal transduction pathway|positive regulation by organism of defense-related host MAPK-mediated signal transduction pathway|up-regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway|positive regulation by symbiont of defense-related host MAP kinase-mediated signal transduction pathway https://github.com/geneontology/go-ontology/issues/19235 GO:0052276 biological_process owl:Class
GO:0003064 biolink:NamedThing regulation of heart rate by hormone The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action. got7fsn_ti hormonal cardiac chronotropy|regulation of the rate of heart contraction by hormone biological_process owl:Class
GO:0072058 biolink:NamedThing outer stripe development The process whose specific outcome is the progression of the outer stripe over time, from its formation to the mature structure. The outer stripe is the region of the kidney outer medulla that lies just below the cortex. The proximal straight tubules (S3) characterize this region. got7fsn_ti mah 2010-01-25T04:02:56Z biological_process owl:Class
GO:0032207 biolink:NamedThing regulation of telomere maintenance via recombination Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. got7fsn_ti biological_process owl:Class
GO:0032108 biolink:NamedThing negative regulation of response to nutrient levels Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels. got7fsn_ti downregulation of response to nutrient levels|down-regulation of response to nutrient levels|down regulation of response to nutrient levels|inhibition of response to nutrient levels biological_process owl:Class
GO:0070621 biolink:NamedThing EGFR-Shc-Grb2-Sos complex A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway. got7fsn_ti mah 2009-04-29T04:38:10Z cellular_component owl:Class
GO:0102799 biolink:NamedThing glucosinolate glucohydrolase activity Catalysis of the reaction: H2O + a glucosinolate = alpha-D-glucose + a thiohydroximate-O-sulfate. Glucosinolates are a subclass of thioglucosides. got7fsn_ti EC:3.2.1.147|MetaCyc:RXN-8134 molecular_function owl:Class
GO:0050640 biolink:NamedThing isopenicillin-N N-acyltransferase activity Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate. got7fsn_ti acyl-CoA:isopenicillin N N-acyltransferase activity|acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase activity|isopenicillin N:acyl-CoA acyltransferase activity|isopenicillin-N acyltransferase activity|acyl-coenzyme A:isopenicillin N acyltransferase activity GO:0045440|GO:0042319 RHEA:20720|EC:2.3.1.164|MetaCyc:2.3.1.164-RXN molecular_function owl:Class
GO:0046680 biolink:NamedThing response to DDT Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a DDT stimulus. DDT, dichlorodiphenyltrichloroethane, is a chlorinated hydrocarbon pesticide moderately toxic to humans and other animals. got7fsn_ti DDT resistance|DDT susceptibility/resistance biological_process owl:Class
GO:0071492 biolink:NamedThing cellular response to UV-A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. got7fsn_ti cellular response to UV-A light stimulus|cellular response to UVA light stimulus|cellular response to UV-A radiation stimulus|cellular response to UVA radiation stimulus mah 2009-12-18T02:21:51Z biological_process owl:Class
GO:0001694 biolink:NamedThing histamine biosynthetic process The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. got7fsn_ti histamine synthesis|histamine biosynthesis|histamine anabolism|histamine formation GO:0001693 biological_process owl:Class
GO:0047594 biolink:NamedThing 6-beta-hydroxyhyoscyamine epoxidase activity Catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O(2) = CO(2) + H(2)O + H(+) + scopolamine + succinate. got7fsn_ti (6S)-6-hydroxyhyoscyamine,2-oxoglutarate oxidoreductase (epoxide-forming)|hydroxyhyoscyamine dioxygenase activity|6beta-hydroxyhyoscyamine epoxidase activity MetaCyc:6-BETA-HYDROXYHYOSCYAMINE-EPOXIDASE-RXN|RHEA:12797|KEGG_REACTION:R03737|EC:1.14.20.13 molecular_function owl:Class
GO:0014830 biolink:NamedThing arteriole smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries. got7fsn_ti biological_process owl:Class
GO:0004046 biolink:NamedThing aminoacylase activity Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. got7fsn_ti N-acyl-L-amino-acid amidohydrolase activity|benzamidase activity|L-amino-acid acylase activity|short acyl amidoacylase activity|hippurase activity|L-aminoacylase activity|histozyme activity|aminoacylase I activity|dehydropeptidase II activity|amido acid deacylase activity|acylase I activity|long acyl amidoacylase activity|alpha-N-acylaminoacid hydrolase activity RHEA:15565|Reactome:R-HSA-9638046|EC:3.5.1.14|Reactome:R-HSA-5433074|MetaCyc:AMINOACYLASE-RXN|Reactome:R-HSA-5579081 molecular_function owl:Class
GO:0048189 biolink:NamedThing Lid2 complex A protein complex involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid2, Ash2, Jmj3, Snt2, and Sdc1. got7fsn_ti https://github.com/geneontology/go-ontology/issues/22010 cellular_component owl:Class
GO:0097099 biolink:NamedThing structural constituent of albumen The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo. got7fsn_ti structural constituent of egg white pr 2011-07-07T02:12:51Z molecular_function owl:Class
GO:0042398 biolink:NamedThing cellular modified amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. got7fsn_ti cellular amino acid derivative anabolism|cellular amino acid derivative synthesis|cellular modified amino acid formation|cellular modified amino acid anabolism|cellular modified amino acid synthesis|cellular amino acid derivative biosynthesis|cellular amino acid derivative formation|cellular modified amino acid biosynthesis|amino acid derivative biosynthetic process|cellular amino acid derivative biosynthetic process biological_process owl:Class
GO:0004485 biolink:NamedThing methylcrotonoyl-CoA carboxylase activity Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate. got7fsn_ti MCCC activity|beta-methylcrotonyl-CoA carboxylase activity|beta-methylcrotonyl coenzyme A carboxylase activity|beta-methylcrotonyl CoA carboxylase activity|3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)|methylcrotonyl-CoA carboxylase activity|methylcrotonyl coenzyme A carboxylase activity EC:6.4.1.4|MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN|KEGG_REACTION:R04138|RHEA:13589|Reactome:R-HSA-508308|Reactome:R-HSA-70773 molecular_function owl:Class
GO:0046842 biolink:NamedThing trisporic acid biosynthetic process The chemical reactions and pathways resulting in the formation of trisporic acid. got7fsn_ti trisporic acid synthesis|trisporic acid formation|trisporic acid anabolism|trisporic acid biosynthesis biological_process owl:Class
GO:0009519 biolink:NamedThing middle lamella Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells. got7fsn_ti Wikipedia:Middle_lamella cellular_component owl:Class
GO:0103089 biolink:NamedThing methylthiohexylmalate isomerase activity Catalysis of the reaction: 2-(6'-methylthio)hexylmalate <=> 3-(6'-methylthio)hexylmalate. got7fsn_ti MetaCyc:RXNQT-4173 molecular_function owl:Class
GO:0034792 biolink:NamedThing hypophosphite dioxygenase activity Catalysis of the reaction: hypophosphite + 2-oxoglutarate + O2 = succinate + phosphite + CO2. got7fsn_ti UM-BBD_reactionID:r1058 molecular_function owl:Class
GO:0047627 biolink:NamedThing adenylylsulfatase activity Catalysis of the reaction: 5'-adenylyl sulfate + H(2)O = AMP + 2 H(+) + sulfate. got7fsn_ti adenosine 5-phosphosulfate sulfohydrolase activity|adenylylsulfate sulfohydrolase activity|adenylylsulphatase activity MetaCyc:ADENYLYLSULFATASE-RXN|EC:3.6.2.1|RHEA:17041|KEGG_REACTION:R00531 molecular_function owl:Class
GO:0052911 biolink:NamedThing 23S rRNA (guanine(745)-N(1))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine. got7fsn_ti S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity|rRNA(m(1)G)methylase activity|ribosomal RNA(m(1)G)-methylase activity|23S rRNA m(1)G(745) methyltransferase activity|ribosomal ribonucleate guanine 1-methyltransferase activity|rlmA(I) methyltransferase activity RHEA:42900|KEGG_REACTION:R07233|EC:2.1.1.187|MetaCyc:RXN-11573 molecular_function owl:Class
GO:0007374 biolink:NamedThing posterior midgut invagination Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior. got7fsn_ti biological_process owl:Class
GO:0061420 biolink:NamedThing regulation of transcription from RNA polymerase II promoter in response to biotin starvation Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin. got7fsn_ti dph 2012-01-25T09:55:39Z biological_process owl:Class
GO:0002193 biolink:NamedThing MAML1-RBP-Jkappa- ICN1 complex A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML1-CSL-Notch1 complex|MAML1-CSL-ICN1|MAML1-RBP-Jkappa-Notch1 complex hjd 2011-08-11T04:08:18Z cellular_component owl:Class
GO:1990812 biolink:NamedThing growth cone filopodium A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone. got7fsn_ti sl 2015-07-24T22:35:16Z cellular_component owl:Class
GO:0102914 biolink:NamedThing N-methyl-3-aminomethylindole N-methyltransferase activity Catalysis of the reaction: N-methyl-3-aminomethylindole + S-adenosyl-L-methionine = H+ + gramine + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:52272|MetaCyc:RXN-8687 molecular_function owl:Class
GO:0043602 biolink:NamedThing nitrate catabolic process The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid. got7fsn_ti nitrate disassimilation|nitrate dissimilation biological_process owl:Class
GO:0050436 biolink:NamedThing microfibril binding Binding to a microfibril, any small fibril occurring in biological material. got7fsn_ti See also the cellular component term 'microfibril ; GO:0001527'. molecular_function owl:Class
GO:0033069 biolink:NamedThing ansamycin metabolic process The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity. got7fsn_ti ansamycin metabolism biological_process owl:Class
GO:0032257 biolink:NamedThing maintenance of dense core granule location Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of dense core granule localization|maintenance of dense core vesicle location biological_process owl:Class
GO:0003835 biolink:NamedThing beta-galactoside alpha-2,6-sialyltransferase activity Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine. got7fsn_ti CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity|CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity|beta-galactosamide alpha-2,6-sialyltransferase activity Reactome:R-HSA-977228|Reactome:R-HSA-977071|MetaCyc:2.4.99.1-RXN|EC:2.4.99.1|Reactome:R-HSA-975902|RHEA:11836|Reactome:R-HSA-4085033 molecular_function owl:Class
GO:0061182 biolink:NamedThing negative regulation of chondrocyte development Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate. got7fsn_ti dph 2010-07-14T08:33:05Z biological_process owl:Class
GO:0002184 biolink:NamedThing cytoplasmic translational termination The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon. got7fsn_ti hjd 2011-06-09T03:17:13Z biological_process owl:Class
GO:0070269 biolink:NamedThing pyroptosis A caspase-1-dependent cell death subroutine that is associated with the generation of pyrogenic mediators such as IL-1beta and IL-18. got7fsn_ti biological_process owl:Class
GO:0017084 biolink:NamedThing delta1-pyrroline-5-carboxylate synthetase activity Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate. got7fsn_ti D1-pyrroline-5-carboxylate synthetase activity Reactome:R-HSA-508040|RHEA:33207 molecular_function owl:Class
GO:0110105 biolink:NamedThing mRNA cleavage and polyadenylation specificity factor complex assembly The aggregation, arrangement and bonding together of a set of components to form the mRNA cleavage and polyadenylation specificity factor complex. got7fsn_ti kmv 2018-04-13T19:05:17Z biological_process owl:Class
GO:0047730 biolink:NamedThing carnosine synthase activity Catalysis of the reaction: ATP + L-histidine + beta-alanine = AMP + diphosphate + carnosine. got7fsn_ti L-histidine:beta-alanine ligase (AMP-forming)|carnosine-anserine synthetase activity|carnosine-homocarnosine synthetase activity|carnosine synthetase activity|homocarnosine-carnosine synthetase activity Reactome:R-HSA-6786245|RHEA:19297|MetaCyc:CARNOSINE-SYNTHASE-RXN|EC:6.3.2.11 molecular_function owl:Class
GO:0000374 biolink:NamedThing Group III intron splicing The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved. got7fsn_ti mRNA splicing Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists. biological_process owl:Class
GO:0042359 biolink:NamedThing vitamin D metabolic process The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). got7fsn_ti cholecalciferol metabolic process|ergocalciferol metabolism|calciferol metabolism|calciferol metabolic process|cholecalciferol metabolism|ergocalciferol metabolic process|vitamin D metabolism biological_process owl:Class
GO:0002540 biolink:NamedThing leukotriene production involved in inflammatory response The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti leukotriene production involved in acute inflammatory response biological_process owl:Class
GO:0018602 biolink:NamedThing 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2. got7fsn_ti MetaCyc:RXN-9863|UM-BBD_reactionID:r0274|RHEA:48984 molecular_function owl:Class
GO:1900617 biolink:NamedThing emericellamide A biosynthetic process The chemical reactions and pathways resulting in the formation of emericellamide A. got7fsn_ti emericellamide A anabolism|emericellamide A biosynthesis|emericellamide A synthesis|emericellamide A formation di 2012-05-15T08:00:27Z biological_process owl:Class
GO:0001651 biolink:NamedThing dense fibrillar component A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins. got7fsn_ti pars fibrosa NIF_Subcellular:sao1841764412 cellular_component owl:Class
GO:0043107 biolink:NamedThing type IV pilus-dependent motility Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility. got7fsn_ti TFP-dependent motility|type four pilus-dependent motility|TFP-dependent movement|social gliding motility|type 4 pilus-dependent motility|twitching motility biological_process owl:Class
GO:0047647 biolink:NamedThing alkylacetylglycerophosphatase activity Catalysis of the reaction: 1-alkyl-2-acetyl-sn-glycerol 3-phosphate + H(2)O = 2-acetyl-1-alkyl-sn-glycerol + phosphate. got7fsn_ti alkylacetylglycerophosphate phosphatase activity|1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase activity|1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase activity EC:3.1.3.59|MetaCyc:ALKYLACETYLGLYCEROPHOSPHATASE-RXN|KEGG_REACTION:R03454|RHEA:18221 molecular_function owl:Class
GO:0050935 biolink:NamedThing iridophore differentiation The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance. got7fsn_ti iridophore cell differentiation biological_process owl:Class
GO:0030220 biolink:NamedThing platelet formation The process in which platelets bud from long processes extended by megakaryocytes. got7fsn_ti platelet extrusion biological_process owl:Class
GO:0015996 biolink:NamedThing chlorophyll catabolic process The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products. got7fsn_ti chlorophyll degradation|chlorophyll breakdown|chlorophyll catabolism biological_process owl:Class
GO:0061619 biolink:NamedThing glycolytic process from mannose through fructose-6-phosphate The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH. got7fsn_ti dph 2014-04-14T09:13:13Z biological_process owl:Class
GO:0102030 biolink:NamedThing dTDP-L-rhamnose synthetase activity Catalysis of the reaction: dTDP-6-deoxy-beta-L-mannose + NAD+ <=> dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H+. got7fsn_ti MetaCyc:DTDPRHAMSYNTHMULTI-RXN molecular_function owl:Class
GO:0031506 biolink:NamedThing cell wall glycoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues. got7fsn_ti cell wall glycoprotein anabolism|cell wall glycoprotein synthesis|cell wall glycoprotein formation|cell wall glycoprotein biosynthesis biological_process owl:Class
GO:0047279 biolink:NamedThing sn-glycerol-3-phosphate 1-galactosyltransferase activity Catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP. got7fsn_ti uridine diphosphogalactose-glycerol phosphate galactosyltransferase activity|UDPgalactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity|UDPgalactose:sn-glycerol-3-phosphate alpha-D-galactosyltransferase activity|glycerol 3-phosphate 1alpha-galactosyltransferase activity|isofloridoside-phosphate synthase activity|UDP-galactose:sn-glycerol-3-phosphate 1-alpha-D-galactosyltransferase activity|UDP-Gal:sn-glycero-3-phosphoric acid 1-alpha-galactosyl-transferase activity MetaCyc:2.4.1.96-RXN|KEGG_REACTION:R00854|RHEA:20341|EC:2.4.1.96 molecular_function owl:Class
GO:0002945 biolink:NamedThing cyclin K-CDK13 complex A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti CycK/Cdk13 complex hjd 2012-12-05T16:13:28Z cellular_component owl:Class
GO:0008834 biolink:NamedThing di-trans,poly-cis-decaprenylcistransferase activity Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate. got7fsn_ti undecaprenyl pyrophosphate synthase activity|undecaprenyl-diphosphate synthase activity|UPP synthetase activity|di-trans,poly-cis-undecaprenyl-diphosphate synthase activity|undecaprenyl diphosphate synthase activity|undecaprenyl pyrophosphate synthetase activity|di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity|bactoprenyl-diphosphate synthase activity|undecaprenyl diphosphate synthetase activity MetaCyc:RXN-8999|RHEA:27551|EC:2.5.1.31 molecular_function owl:Class
GO:0097058 biolink:NamedThing CRLF-CLCF1 complex A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex. got7fsn_ti CLF-CLC complex pr 2011-05-26T10:37:55Z cellular_component owl:Class
GO:0072673 biolink:NamedThing lamellipodium morphogenesis A process that is carried out at the cellular level and in which the structure of a lamellipodium is organized. got7fsn_ti lamellipodium organization mah 2011-02-21T03:11:55Z biological_process owl:Class
GO:0080175 biolink:NamedThing phragmoplast microtubule organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in phragmoplast, a plant cell specific structure that forms during late cytokinesis. Phragmoplast serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells. got7fsn_ti phragmoplast microtubule cytoskeleton organization|phragmoplast microtubule organisation dhl 2011-04-28T03:54:11Z biological_process owl:Class
GO:0050508 biolink:NamedThing glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP. got7fsn_ti alpha-N-acetylglucosaminyltransferase II activity|UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity|glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity MetaCyc:2.4.1.224-RXN|Reactome:R-HSA-3656254|Reactome:R-HSA-2022851|Reactome:R-HSA-3656261|Reactome:R-HSA-2022919|Reactome:R-HSA-9036283|RHEA:16213|Reactome:R-HSA-9036290|EC:2.4.1.224 molecular_function owl:Class
GO:0001691 biolink:NamedThing pseudophosphatase activity Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues. got7fsn_ti molecular_function owl:Class
GO:0019212 biolink:NamedThing phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. got7fsn_ti molecular_function owl:Class
GO:0060885 biolink:NamedThing clearance of cells from fusion plate by apoptotic process Any apoptotic process that contributes to the shaping of the semicircular canal by removing cells in the fusion plate, forming the loops of the canals. got7fsn_ti clearance of cells from fusion plate by apoptosis dph 2009-08-13T12:30:17Z biological_process owl:Class
GO:0046505 biolink:NamedThing sulfolipid metabolic process The chemical reactions and pathways involving sulfolipids, any compound containing a sulfonic acid residue joined by a carbon-sulfur bond to a lipid. got7fsn_ti sulpholipid metabolism|sulpholipid metabolic process|sulfolipid metabolism biological_process owl:Class
GO:0003150 biolink:NamedThing muscular septum morphogenesis The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum. got7fsn_ti tb 2009-09-22T07:53:28Z biological_process owl:Class
GO:0070572 biolink:NamedThing positive regulation of neuron projection regeneration Any process that activates or increases the frequency, rate or extent of neuron projection regeneration, the regrowth of neuronal processes such as axons or dendrites following their loss or damage. got7fsn_ti mah 2009-04-15T01:45:27Z biological_process owl:Class
GO:0010976 biolink:NamedThing positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). got7fsn_ti positive regulation of neurite growth|positive regulation of neurite development|positive regulation of neurite formation|positive regulation of neurite biosynthesis tb 2009-06-01T10:46:44Z biological_process owl:Class
GO:0038008 biolink:NamedThing TRAF-mediated signal transduction The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components. got7fsn_ti tumor necrosis factor receptor-associated factor signaling|tumor necrosis factor receptor-associated factor signal transduction|TRAF-mediated signalling|TRAF-mediated intracellular signaling|TRAF-mediated signaling|TRAF signaling bf 2011-06-22T04:01:54Z biological_process owl:Class
GO:0071861 biolink:NamedThing tachykinin receptor binding Binding to a tachykinin receptor. got7fsn_ti mah 2010-09-10T03:24:34Z molecular_function owl:Class
GO:0036238 biolink:NamedThing gallate dioxygenase activity Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate. got7fsn_ti bf 2012-05-22T01:54:09Z KEGG_REACTION:R09565|MetaCyc:GALLATE-DIOXYGENASE-RXN|EC:1.13.11.57|RHEA:28927 molecular_function owl:Class
GO:0090610 biolink:NamedThing bundle sheath cell fate specification The process in which a cell becomes capable of differentiating autonomously into a bundle sheath cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti tb 2014-09-26T13:17:05Z biological_process owl:Class
GO:0033718 biolink:NamedThing pyranose dehydrogenase (acceptor) activity Catalysis of the reactions: pyranose + acceptor = 2-dehydropyranose (or 3-dehydropyranose or 2,3-didehydropyranose) + reduced acceptor, and a pyranoside + acceptor = a 3-dehydropyranoside (or 3,4-didehydropyranoside) + reduced acceptor. got7fsn_ti pyranose:acceptor oxidoreductase activity|quinone-dependent pyranose dehydrogenase activity|pyranose dehydrogenase activity|pyranose-quinone oxidoreductase activity|PDH MetaCyc:RXN-7963|MetaCyc:RXN-7965|MetaCyc:RXN-7962|MetaCyc:RXN-7966|EC:1.1.99.29|MetaCyc:RXN-7961 molecular_function owl:Class
GO:0047615 biolink:NamedThing actinomycin lactonase activity Catalysis of the reaction: actinomycin + H2O = actinomycinic monolactone. got7fsn_ti actinomycin lactonohydrolase activity EC:3.1.1.39|MetaCyc:ACTINOMYCIN-LACTONASE-RXN molecular_function owl:Class
GO:0102472 biolink:NamedThing eriodictyol 2-hydroxylase activity Catalysis of the reaction: eriodictyol + NADPH + O2 + 2 H+ <=> 2-hydroxyeriodictyol + NADP + H2O. got7fsn_ti RHEA:57596|MetaCyc:RXN-14077 molecular_function owl:Class
GO:0008855 biolink:NamedThing exodeoxyribonuclease VII activity Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. got7fsn_ti endodeoxyribonuclease VII|E. coli exonuclease VII|exonuclease VII activity|E. coli exonuclease VII activity|Escherichia coli exonuclease VII EC:3.1.11.6|MetaCyc:3.1.11.6-RXN molecular_function owl:Class
GO:0019802 biolink:NamedThing cyclization of glutamine involved in intein-mediated protein splicing The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing. got7fsn_ti cyclization of glutamine, during protein splicing Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. RESID:AA0303 biological_process owl:Class
GO:0016767 biolink:NamedThing geranylgeranyl-diphosphate geranylgeranyltransferase activity Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate. got7fsn_ti phytoene synthetase activity|prephytoene-diphosphate synthase activity|PSase activity|geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity MetaCyc:2.5.1.32-RXN|EC:2.5.1.32|RHEA:22296 molecular_function owl:Class
GO:0102893 biolink:NamedThing betanidin 6-O-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + betanidin <=> H+ + gomphrenin I + UDP. got7fsn_ti MetaCyc:RXN-8480 molecular_function owl:Class
GO:1990261 biolink:NamedThing pre-mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA). got7fsn_ti pre-mRNA decay|unspliced RNA decay rb 2014-01-07T23:06:44Z biological_process owl:Class
GO:0071837 biolink:NamedThing HMG box domain binding Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. got7fsn_ti mah 2010-09-10T12:05:45Z molecular_function owl:Class
GO:0000294 biolink:NamedThing nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends. got7fsn_ti mRNA catabolic process, endonucleolytic|mRNA degradation, endonucleolytic cleavage-dependent decay|mRNA breakdown, endonucleolytic cleavage-dependent decay|mRNA catabolism, endonucleolytic|endonucleolytic mRNA decay|nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay biological_process owl:Class
GO:0004816 biolink:NamedThing asparagine-tRNA ligase activity Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+). got7fsn_ti asparaginyl transfer RNA synthetase activity|asparagyl-transfer RNA synthetase activity|asparagine translase activity|asparaginyl-tRNA synthetase activity|asparaginyl transfer ribonucleic acid synthetase activity|asparaginyl-transfer ribonucleate synthetase activity|L-asparagine:tRNAAsn ligase (AMP-forming) Reactome:R-HSA-380227|Reactome:R-HSA-379996|KEGG_REACTION:R03648|RHEA:11180|MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN|EC:6.1.1.22 molecular_function owl:Class
GO:0008824 biolink:NamedThing cyanate hydratase activity Catalysis of the reaction: cyanate + H2O = carbamate. got7fsn_ti cyanate lyase activity|cyanate aminohydrolase activity|carbamate hydro-lyase activity|cyanate hydrolase activity|cyanate C-N-lyase activity|cyanase activity Note that this function was formerly EC:4.3.99.1. EC:4.2.1.104|MetaCyc:R524-RXN|UM-BBD_reactionID:r0608|RHEA:11120 molecular_function owl:Class
GO:0018521 biolink:NamedThing 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO(2) + NADH. got7fsn_ti 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating) UM-BBD_reactionID:r0224|EC:1.3.1.68|RHEA:15657|MetaCyc:1.3.1.68-RXN|KEGG_REACTION:R05314 molecular_function owl:Class
GO:0003304 biolink:NamedThing myocardial epithelial involution involved in heart jogging The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging. got7fsn_ti dph 2009-10-22T11:03:33Z biological_process owl:Class
GO:0051971 biolink:NamedThing positive regulation of transmission of nerve impulse Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation. got7fsn_ti up-regulation of transmission of nerve impulse|activation of transmission of nerve impulse|upregulation of transmission of nerve impulse|positive regulation of conduction of nerve impulse|up regulation of transmission of nerve impulse|stimulation of transmission of nerve impulse biological_process owl:Class
GO:0010919 biolink:NamedThing regulation of inositol phosphate biosynthetic process Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. got7fsn_ti regulation of inositol phosphate biosynthesis biological_process owl:Class
GO:0071838 biolink:NamedThing cell proliferation in bone marrow The multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow. got7fsn_ti bone marrow cell proliferation mah 2010-09-10T12:15:41Z biological_process owl:Class
GO:0008432 biolink:NamedThing JUN kinase binding Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. got7fsn_ti JNK binding molecular_function owl:Class
GO:0016443 biolink:NamedThing bidentate ribonuclease III activity Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference. got7fsn_ti bidentate RNase III activity EC:3.1.26.- molecular_function owl:Class
GO:0004137 biolink:NamedThing deoxycytidine kinase activity Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. got7fsn_ti deoxycytidine kinase (phosphorylating)|arabinofuranosylcytosine kinase activity|NTP:deoxycytidine 5'-phosphotransferase activity|2'-deoxycytidine kinase activity|Ara-C kinase activity|deoxycytidine-cytidine kinase activity EC:2.7.1.74|RHEA:20061|MetaCyc:DEOXYCYTIDINE-KINASE-RXN molecular_function owl:Class
GO:0047029 biolink:NamedThing (R)-4-hydroxyphenyllactate dehydrogenase (NADPH) activity Catalysis of the reaction: NADP+ + (R)-3-(4-hydroxyphenyl)lactate = NADPH + H+ + 3-(4-hydroxyphenyl)pyruvate. got7fsn_ti aromatic 2-oxoacid reductase activity|phenylpyruvate reductase activity|hydroxyphenylpyruvate reductase activity https://github.com/geneontology/go-ontology/issues/21412|EC:1.1.1.110|MetaCyc:RXN-7632|RHEA:52692 molecular_function owl:Class
GO:0120091 biolink:NamedThing jasmonic acid hydrolase Catalyzes the hydroxylation of jasmonic acid to 12OH-jasmonic acid. got7fsn_ti 2-oxoglutarate dioxygenase krc 2017-08-18T23:25:52Z molecular_function owl:Class
GO:0045298 biolink:NamedThing tubulin complex A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly. got7fsn_ti cellular_component owl:Class
GO:0003109 biolink:NamedThing positive regulation of the force of heart contraction by circulating norepinephrine The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction. got7fsn_ti increased force of heart contraction by circulating noradrenaline|increased force of heart contraction by circulating norepinephrine biological_process owl:Class
GO:0047591 biolink:NamedThing 5-hydroxypentanoate CoA-transferase activity Catalysis of the reaction: 5-hydroxypentanoate + acetyl-CoA = 5-hydroxy-pentanoyl-CoA + acetate. got7fsn_ti 5-hydroxyvalerate coenzyme A transferase activity|acetyl-CoA:5-hydroxypentanoate CoA-transferase activity|5-hydroxyvalerate CoA-transferase activity RHEA:23496|KEGG_REACTION:R04057|MetaCyc:5-HYDROXYPENTANOATE-COA-TRANSFERASE-RXN|EC:2.8.3.14 molecular_function owl:Class
GO:0019671 biolink:NamedThing glutamate catabolic process via mesaconate and citramalate The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP. got7fsn_ti glutamate fermentation via mesaconate and citramalate MetaCyc:PWY-5087|MetaCyc:GLUDEG-II-PWY|MetaCyc:PWY-5088 biological_process owl:Class
GO:0102795 biolink:NamedThing 1-naphthaldehyde:oxygen oxidoreductase activity Catalysis of the reaction: 1-naphthaldehyde + O2 + H2O = H+ + 1-naphthoate + hydrogen peroxide. got7fsn_ti MetaCyc:RXN-8090|EC:1.2.3.9 molecular_function owl:Class
GO:1990032 biolink:NamedThing parallel fiber A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium. got7fsn_ti pr 2013-02-07T12:58:43Z NIF_Subcellular:nlx_330 cellular_component owl:Class
GO:0071195 biolink:NamedThing Kv4.2-KChIP4 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2. got7fsn_ti mah 2009-11-23T04:59:06Z CORUM:3090 cellular_component owl:Class
GO:0018562 biolink:NamedThing 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r0415 molecular_function owl:Class
GO:0106238 biolink:NamedThing peregrinol diphosphate synthase activity Catalysis of the reaction:peregrinol diphosphate = all-trans-geranylgeranyl diphosphate + H2O. got7fsn_ti hjd 2019-12-19T15:28:28Z RHEA:54652|EC:4.2.1.174 molecular_function owl:Class
GO:0016156 biolink:NamedThing fumarate reductase (NADH) activity Catalysis of the reaction: NAD(+) + succinate = fumarate + H(+) + NADH. got7fsn_ti NADH-dependent fumarate reductase activity|succinate:NAD+ oxidoreductase activity|NADH-fumarate reductase activity EC:1.3.1.6|MetaCyc:FUMARATE-REDUCTASE-NADH-RXN|KEGG_REACTION:R00402|RHEA:18281 molecular_function owl:Class
GO:0048212 biolink:NamedThing Golgi vesicle uncoating The process in which Golgi vesicle coat proteins are depolymerized, and released for reuse. got7fsn_ti Golgi vesicle coat depolymerization|dictyosome vesicle coat depolymerization|Golgi vesicle coat protein depolymerization|Golgi-derived vesicle uncoating biological_process owl:Class
GO:0090506 biolink:NamedThing axillary shoot meristem initiation A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf. got7fsn_ti axillary bud meristem initiation tb 2012-10-23T14:47:00Z biological_process owl:Class
GO:0030860 biolink:NamedThing regulation of polarized epithelial cell differentiation Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation. got7fsn_ti biological_process owl:Class
GO:0008613 biolink:NamedThing diuretic hormone activity The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion. got7fsn_ti molecular_function owl:Class
GO:0050260 biolink:NamedThing ribose-5-phosphate-ammonia ligase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH(4)(+) = 5-phospho-D-ribosylamine + ADP + 2 H(+) + phosphate. got7fsn_ti ammonia-ribose 5-phosphate aminotransferase activity|5-phosphoribosylamine synthetase activity|ribose-5-phosphate:ammonia ligase (ADP-forming)|ribose 5-phosphate aminotransferase activity EC:6.3.4.7|MetaCyc:RIBOSE-5-PHOSPHATE--AMMONIA-LIGASE-RXN|KEGG_REACTION:R01053|RHEA:13777 molecular_function owl:Class
GO:0010997 biolink:NamedThing anaphase-promoting complex binding Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. got7fsn_ti APC binding tb 2009-06-10T11:18:22Z molecular_function owl:Class
GO:0008495 biolink:NamedThing protoheme IX farnesyltransferase activity Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate. got7fsn_ti heme A:farnesyltransferase activity|haem O synthase activity|heme O synthase activity|protohaem IX farnesyltransferase activity MetaCyc:HEMEOSYN-RXN|Reactome:R-HSA-2995330|EC:2.5.1.141|RHEA:28070 molecular_function owl:Class
GO:0060279 biolink:NamedThing positive regulation of ovulation Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. got7fsn_ti biological_process owl:Class
GO:0060105 biolink:NamedThing epicuticle of collagen and cuticulin-based cuticle extracellular matrix A lipid-containing layer of cuticle that lies between the cortical layer and the surface coat. An example of this component is found in Caenorhabditis elegans. got7fsn_ti epicuticle of collagen and cuticulin-based exoskeleton extracellular matrix cellular_component owl:Class
GO:0050195 biolink:NamedThing phosphoribokinase activity Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H(+). got7fsn_ti ATP:D-ribose-5-phosphate 1-phosphotransferase activity|phosphoribokinase (phosphorylating) EC:2.7.1.18|KEGG_REACTION:R01050|MetaCyc:PHOSPHORIBOKINASE-RXN|RHEA:21216 molecular_function owl:Class
GO:0051916 biolink:NamedThing granulocyte colony-stimulating factor binding Binding to granulocyte colony-stimulating factor, G-CSF. got7fsn_ti granulocyte colony stimulating factor binding|G-CSF binding molecular_function owl:Class
GO:0033949 biolink:NamedThing fructan beta-(2,6)-fructosidase activity Catalysis of the hydrolysis of terminal, non-reducing (2->6) linked beta-D-fructofuranose residues in fructans. got7fsn_ti 6-FEH|beta-(2,6)-fructan exohydrolase activity|beta-(2,6)-D-fructan fructohydrolase activity MetaCyc:3.2.1.154-RXN|EC:3.2.1.154 molecular_function owl:Class
GO:0017126 biolink:NamedThing nucleologenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. got7fsn_ti nucleolus biogenesis|nucleolus assembly biological_process owl:Class
GO:0010455 biolink:NamedThing positive regulation of cell fate commitment Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field. got7fsn_ti biological_process owl:Class
GO:0033516 biolink:NamedThing L-methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-phospho-L-homoserine and cystathionine. got7fsn_ti L-methionine formation from homoserine via O-phospho-L-homoserine and cystathionine|L-methionine synthesis from homoserine via O-phospho-L-homoserine and cystathionine|methionine biosynthetic process from homoserine via O-phospho-L-homoserine and cystathionine|L-methionine anabolism from homoserine via O-phospho-L-homoserine and cystathionine MetaCyc:PWY-702 biological_process owl:Class
GO:0042614 biolink:NamedThing CD70 receptor binding Binding to a CD70, a receptor found on the surface of most activated B cells and some activated T cells. got7fsn_ti CD27 receptor activity|CD27L binding molecular_function owl:Class
GO:0008709 biolink:NamedThing cholate 7-alpha-dehydrogenase activity Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH. got7fsn_ti 7alpha-hydroxysteroid dehydrogenase activity|7-alpha-hydroxysteroid dehydrogenase activity|7alpha-HSDH|7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity|7alpha-hydroxy steroid dehydrogenase activity RHEA:19409|EC:1.1.1.159|MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN|KEGG_REACTION:R02792 molecular_function owl:Class
GO:0047431 biolink:NamedThing 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase activity Catalysis of the reaction: 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + H(+) = 5-hydroxy-6-methylpyridine-3-carboxylate + CO(2). got7fsn_ti 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase (3-hydroxy-2-methylpyridine-5-carboxylate-forming)|3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-carboxy-lyase activity KEGG_REACTION:R03461|RHEA:13669|MetaCyc:4.1.1.51-RXN|EC:4.1.1.51 molecular_function owl:Class
GO:0050602 biolink:NamedThing monoprenyl isoflavone epoxidase activity Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives. got7fsn_ti 7-O-methylluteone,NADPH:O2 oxidoreductase activity|7-O-methylluteone:O2 oxidoreductase activity|monoprenyl isoflavone monooxygenase activity MetaCyc:1.14.99.34-RXN|EC:1.14.99.34 molecular_function owl:Class
GO:0050507 biolink:NamedThing indoxyl-UDPG glucosyltransferase activity Catalysis of the reaction: indoxyl + UDP-D-glucose = H(+) + indican + UDP. got7fsn_ti UDP-glucose:indoxyl 3-O-beta-D-glucosyltransferase activity|indoxyl-UDPG-glucosyltransferase activity EC:2.4.1.220|RHEA:12004|MetaCyc:2.4.1.220-RXN|KEGG_REACTION:R06048 molecular_function owl:Class
GO:1990949 biolink:NamedThing metaphase/anaphase transition of meiosis I The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis I. got7fsn_ti meiosis I metaphase/anaphase transition|first meiotic metaphase/anaphase transition mah 2016-04-25T15:27:32Z biological_process owl:Class
GO:0004751 biolink:NamedThing ribose-5-phosphate isomerase activity Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. got7fsn_ti D-ribose 5-phosphate isomerase activity|phosphopentosisomerase activity|5-phosphoribose isomerase activity|ribose 5-phosphate epimerase activity|phosphopentoseisomerase activity|phosphoriboisomerase activity|ribose phosphate isomerase activity|D-ribose-5-phosphate aldose-ketose-isomerase activity|D-ribose-5-phosphate ketol-isomerase activity EC:5.3.1.6|Reactome:R-HSA-5660013|Reactome:R-HSA-71306|KEGG_REACTION:R01056|Reactome:R-HSA-177784|RHEA:14657|Reactome:R-HSA-5660015|MetaCyc:RIB5PISOM-RXN molecular_function owl:Class
GO:0010614 biolink:NamedThing negative regulation of cardiac muscle hypertrophy Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. got7fsn_ti biological_process owl:Class
GO:0008684 biolink:NamedThing 2-oxopent-4-enoate hydratase activity Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O. got7fsn_ti 2-keto-4-pentenoate (vinylpyruvate)hydratase activity|2-keto-4-pentenoate hydratase activity|OEH activity|4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)|4-hydroxy-2-oxopentanoate hydro-lyase activity GO:0018821 EC:4.2.1.80|MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN|RHEA:22580|UM-BBD_enzymeID:e0078 molecular_function owl:Class
GO:0018832 biolink:NamedThing halohydrin hydrogen-halide-lyase B activity Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane. got7fsn_ti UM-BBD_enzymeID:e0050 molecular_function owl:Class
GO:1990621 biolink:NamedThing ESCRT IV complex An ESCRT complex that has AAA-ATPase activity and is involved in ESCRT-mediated intralumenal vesicle formation and the final stages of cytokinesis. The complex catalyzes disassembly of the ESCRT III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1. got7fsn_ti Vps4 complex|Vps4-Vta1 complex|ESCRT-IV|vacuolar protein sorting-associated complex|VPS4A/B complex|VPS4A-VPS4B|Vta1-Vps4 complex pr 2015-01-29T10:02:30Z cellular_component owl:Class
GO:0007562 biolink:NamedThing eclosion The emergence of an adult insect from a pupa case. got7fsn_ti Wikipedia:Pupa#Emergence biological_process owl:Class
GO:0034383 biolink:NamedThing low-density lipoprotein particle clearance The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. got7fsn_ti LDL clearance biological_process owl:Class
GO:0050015 biolink:NamedThing kievitone hydratase activity Catalysis of the reaction: kievitone hydrate = H(2)O + H(+) + kievitone. got7fsn_ti kievitone-hydrate hydro-lyase (kievitone-forming)|KHase activity|kievitone-hydrate hydro-lyase activity RHEA:23604|MetaCyc:KIEVITONE-HYDRATASE-RXN|EC:4.2.1.95|KEGG_REACTION:R03622 molecular_function owl:Class
GO:0102965 biolink:NamedThing alcohol-forming fatty acyl-CoA reductase activity Catalysis of the reaction: 2 NADPH + 2 H+ + a long-chain acyl-CoA = coenzyme A + 2 NADP + a long-chain alcohol. got7fsn_ti MetaCyc:RXN-9344|RHEA:52716|EC:1.2.1.84 molecular_function owl:Class
GO:0044570 biolink:NamedThing starch utilization system complex A bacterial cell envelope-associated multiprotein system, which binds and degrades starch. got7fsn_ti Sus complex jl 2012-04-18T02:46:24Z cellular_component owl:Class
GO:0044685 biolink:NamedThing tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O. got7fsn_ti jl 2012-08-15T14:13:07Z EC:2.1.2.- molecular_function owl:Class
GO:0043885 biolink:NamedThing carbon-monoxide dehydrogenase (ferredoxin) activity Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin. got7fsn_ti carbon-monoxide,water:ferredoxin oxidoreductase activity|CO-dehydrogenase activity|CO dehydrogenase activity|carbon-monoxide dehydrogenase activity|carbon-monoxide:(acceptor) oxidoreductase activity|carbon monoxide dehydrogenase (ferredoxin) activity|CO-dehydrogenase (ferredoxin) activity|carbon monoxide dehydrogenase activity|CODH MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN|EC:1.2.7.4 molecular_function owl:Class
GO:0018846 biolink:NamedThing styrene-oxide isomerase activity Catalysis of the reaction: styrene oxide = phenylacetaldehyde. got7fsn_ti styrene-oxide isomerase (epoxide-cleaving)|SOI activity|styrene oxide isomerase activity EC:5.3.99.7|RHEA:21604|KEGG_REACTION:R02615|MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN|UM-BBD_reactionID:r0034 molecular_function owl:Class
GO:0036340 biolink:NamedThing chitin-based cuticle sclerotization by biomineralization The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate. got7fsn_ti chitin-based cuticle hardening by biomineralisation bf 2012-09-11T13:50:04Z biological_process owl:Class
GO:0031706 biolink:NamedThing subtype 3 bombesin receptor binding Binding to a subtype 3 bombesin receptor. got7fsn_ti subtype 3 bombesin receptor ligand molecular_function owl:Class
GO:0034166 biolink:NamedThing toll-like receptor 10 signaling pathway Any series of molecular signals generated as a consequence of binding to toll-like receptor 10. got7fsn_ti toll-like receptor 10 signalling pathway|TLR10 signaling pathway biological_process owl:Class
GO:0090140 biolink:NamedThing regulation of mitochondrial fission Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. got7fsn_ti regulation of mitochondrial division tb 2009-12-08T02:20:48Z biological_process owl:Class
GO:0140438 biolink:NamedThing protein stearoylation The covalent attachment of a stearoyl group to an amino acid in a protein. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18882 pg 2020-03-11T07:54:48Z biological_process owl:Class
GO:0046562 biolink:NamedThing glucose oxidase activity Catalysis of the reaction: beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2. got7fsn_ti beta-D-glucose:quinone oxidoreductase activity|D-glucose oxidase activity|penatin|deoxin-1|beta-D-glucose:oxygen 1-oxidoreductase activity|D-glucose-1-oxidase activity|GOD activity|beta-D-glucose oxidase activity|beta-D-glucose:oxygen 1-oxido-reductase activity|microcid|glucose aerodehydrogenase activity|corylophyline|glucose oxyhydrase activity RHEA:11428|MetaCyc:GLUCOSE-OXIDASE-RXN|KEGG_REACTION:R01522|EC:1.1.3.4 molecular_function owl:Class
GO:0044256 biolink:NamedThing protein digestion The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism. got7fsn_ti biological_process owl:Class
GO:0017057 biolink:NamedThing 6-phosphogluconolactonase activity Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+). got7fsn_ti 6-PGL|phosphogluconolactonase activity|6-phospho-D-glucono-1,5-lactone lactonohydrolase activity Reactome:R-HSA-71296|EC:3.1.1.31|MetaCyc:6PGLUCONOLACT-RXN|KEGG_REACTION:R02035|RHEA:12556 molecular_function owl:Class
GO:0018802 biolink:NamedThing 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde. got7fsn_ti UM-BBD_reactionID:r0370 molecular_function owl:Class
GO:0050188 biolink:NamedThing phosphoenolpyruvate mutase activity Catalysis of the reaction: phosphoenolpyruvate = 3-phosphonopyruvate. got7fsn_ti phosphoenolpyruvate 2,3-phosphonomutase activity|PEP phosphomutase activity|PEPPM|phosphoenolpyruvate-phosphonopyruvate phosphomutase activity|phosphoenolpyruvate phosphomutase activity|PEP mutase activity EC:5.4.2.9|RHEA:17013|KEGG_REACTION:R00661|MetaCyc:PHOSPHOENOLPYRUVATE-MUTASE-RXN molecular_function owl:Class
GO:0007161 biolink:NamedThing calcium-independent cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction. got7fsn_ti calcium-independent cell adhesion molecule activity biological_process owl:Class
GO:1990624 biolink:NamedThing guanyl nucleotide exchange factor inhibitor activity Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor. got7fsn_ti vw 2015-01-31T15:17:01Z molecular_function owl:Class
GO:0060142 biolink:NamedThing regulation of syncytium formation by plasma membrane fusion Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells. got7fsn_ti biological_process owl:Class
GO:0018794 biolink:NamedThing 2-hydroxyisobutyrate decarboxylase activity Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol. got7fsn_ti UM-BBD_reactionID:r0617 molecular_function owl:Class
GO:0061602 biolink:NamedThing molybdenum cofactor cytidylyltransferase activity Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor. got7fsn_ti dph 2014-02-10T14:46:38Z EC:2.7.7.76|RHEA:31335 molecular_function owl:Class
GO:0009905 biolink:NamedThing ent-copalyl diphosphate synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate. got7fsn_ti diterpene cyclase activity|ent-copalyl-diphosphate lyase (decyclizing)|ent-kaurene synthetase A activity|ent-kaurene synthase A activity RHEA:14841|KEGG_REACTION:R02068|MetaCyc:5.5.1.13-RXN|EC:5.5.1.13 molecular_function owl:Class
GO:0008365 biolink:NamedThing adult chitin-based cuticle development Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster. got7fsn_ti adult chitin-based cuticle anabolism|adult cuticle formation|adult chitin-based cuticle synthesis|adult cuticle biosynthetic process|adult chitin-based cuticle formation|adult chitin-based cuticle biosynthetic process|adult cuticle synthesis|adult cuticle anabolism biological_process owl:Class
GO:1990712 biolink:NamedThing HFE-transferrin receptor complex A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription. got7fsn_ti pr 2015-03-26T13:03:27Z cellular_component owl:Class
GO:0072541 biolink:NamedThing peroxynitrite reductase activity Catalysis of the reaction: 2 R-SH + ONOO- = R-SS-R + NO2- + H2O. got7fsn_ti peroxynitritase activity Note that this activity is usually associated in vivo with an NADPH-dependent disulfide reductase activity, so that catalysis of the reduction of peroxynitrite to nitrite involves the possible creation of oxygen or water, using NADPH as reduction equivalent. mah 2011-01-17T11:43:37Z molecular_function owl:Class
GO:0080123 biolink:NamedThing jasmonate-amino synthetase activity Catalysis of the reaction: jasmonate + an amino acid = an amide-linked jasmonyl-amino acid conjugate. The substrates of this reaction include non-standard amino acids, such as ACC (1-aminocyclopropane-1-carboxylate). got7fsn_ti jasmonyl-amino synthetase activity|jasmonate:amino acid synthetase activity|ja-amino synthetase activity|jasmonate-amino acid synthetase activity|jasmonate-amino acid conjugate synthetase activity|jasmonate-amido synthetase activity|jasmonic acid-amino synthetase activity dhl 2009-04-28T04:08:35Z molecular_function owl:Class
GO:0002116 biolink:NamedThing semaphorin receptor complex A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor. got7fsn_ti plexin-neurophilin complex cellular_component owl:Class
GO:0008780 biolink:NamedThing acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. got7fsn_ti UDP-N-acetylglucosamine acyltransferase activity|acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity|(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity|uridine diphosphoacetylglucosamine acyltransferase activity|acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase|acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN|RHEA:13925|EC:2.3.1.129 molecular_function owl:Class
GO:1990165 biolink:NamedThing single-strand break-containing DNA binding Binding to damaged DNA containing single-strand breaks (SSBs). got7fsn_ti SSB-containing DNA binding|single-strand break-containing damaged DNA binding pr 2013-08-08T11:16:04Z molecular_function owl:Class
GO:0004053 biolink:NamedThing arginase activity Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea. got7fsn_ti L-arginine amidinohydrolase activity|canavanase activity|arginine transamidinase activity|arginine amidinase activity|L-arginase activity Reactome:R-HSA-70569|MetaCyc:ARGINASE-RXN|EC:3.5.3.1|RHEA:20569|Reactome:R-HSA-452036 molecular_function owl:Class
GO:0070533 biolink:NamedThing BRCA1-C complex A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint. got7fsn_ti cellular_component owl:Class
GO:0090460 biolink:NamedThing threonine homeostasis Any process involved in the maintenance of an internal steady state of threonine within an organism or cell. got7fsn_ti tb 2012-09-24T14:22:02Z biological_process owl:Class
GO:0004795 biolink:NamedThing threonine synthase activity Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate. got7fsn_ti O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)|O-phospho-L-homoserine phospho-lyase (adding water)|threonine synthetase activity MetaCyc:THRESYN-RXN|RHEA:10840|EC:4.2.3.1 molecular_function owl:Class
GO:0120065 biolink:NamedThing pyloric antrum smooth muscle contraction A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the widest part of the pylorus that is continuous with the body of the stomach. got7fsn_ti antrum smooth muscle contraction krc 2017-06-13T22:36:20Z biological_process owl:Class
GO:0046658 biolink:NamedThing anchored component of plasma membrane The component of the plasma membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. got7fsn_ti anchored to plasma membrane|plasma membrane, GPI-anchored cellular_component owl:Class
GO:0048881 biolink:NamedThing mechanosensory lateral line system development The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance. got7fsn_ti LL system development biological_process owl:Class
GO:0043802 biolink:NamedThing hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate. got7fsn_ti CobB|hydrogenobyrinic acid a,c diamide synthase (glutamine-hydrolysing) activity|hydrogenobyrinic-acid:L-glutamine amido-ligase (AMP-forming) EC:6.3.5.9|KEGG_REACTION:R05224|RHEA:12544|MetaCyc:R341-RXN molecular_function owl:Class
GO:0043699 biolink:NamedThing leucosome A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast. got7fsn_ti refractosome cellular_component owl:Class
GO:0050388 biolink:NamedThing uronate dehydrogenase activity Catalysis of the reaction: D-galacturonate + H(2)O + NAD(+) = galactarate + 2 H(+) + NADH. got7fsn_ti uronate: NAD-oxidoreductase activity|uronate:NAD+ 1-oxidoreductase activity|uronic acid dehydrogenase activity KEGG_REACTION:R01981|RHEA:22404|EC:1.1.1.203|MetaCyc:URONATE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0044568 biolink:NamedThing secondary cell wall cellulose synthase complex A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4. got7fsn_ti secondary cell wall CesA complex|secondary cell-wall cellulose synthase complex|secondary cell wall CESA complex jl 2012-04-18T12:55:04Z cellular_component owl:Class
GO:0070053 biolink:NamedThing thrombospondin receptor activity Combining with thrombospondin and transmitting the signal to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0075514 biolink:NamedThing endosome lysis involved in viral entry into host cell Viral-induced lysis of the endosome involved in uptake of a virus into a host cell. Occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents from the endosome into the host cell cytoplasm. got7fsn_ti viral entry into host cell via caveolae-mediated endocytosis followed by endosome lysis jl 2011-07-27T02:56:15Z biological_process owl:Class
GO:0140224 biolink:NamedThing SLAC complex A protein complex that regulates Arp2/3 complex-mediated actin nucleation. got7fsn_ti pg 2018-05-29T09:54:08Z cellular_component owl:Class
GO:0034529 biolink:NamedThing 2-hydroxy-3-carboxy-benzalpyruvate hydratase-aldolase activity Catalysis of the reaction: 2-hydroxy-3-carboxybenzalpyruvate + H2O = 3-formylsalicylic acid + pyruvate. got7fsn_ti UM-BBD_reactionID:r0792 molecular_function owl:Class
GO:0060231 biolink:NamedThing mesenchymal to epithelial transition A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. got7fsn_ti mesenchymal-epithelial transition|epithelial cell differentiation from mesenchymal cell biological_process owl:Class
GO:0018763 biolink:NamedThing hydroxydechloroatrazine ethylaminohydrolase activity Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine. got7fsn_ti AtzB|hydroxyatrazine ethylaminohydrolase activity|4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity|hydroxyatrazine hydrolase activity RHEA:23092|UM-BBD_enzymeID:e0085|MetaCyc:R122-RXN|EC:3.5.4.43 molecular_function owl:Class
GO:0061347 biolink:NamedThing planar cell polarity pathway involved in outflow tract morphogenesis The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the outflow tract. got7fsn_ti dph 2010-10-01T10:38:56Z biological_process owl:Class
GO:0043815 biolink:NamedThing phosphoribosylglycinamide formyltransferase 2 activity Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate. got7fsn_ti 5'-phosphoribosylglycinamide transformylase 2|formate-dependent GAR transformylase activity|GART 2|GAR transformylase 2 RHEA:24829|MetaCyc:GARTRANSFORMYL2-RXN molecular_function owl:Class
GO:0097142 biolink:NamedThing PUMA-BCL-2 complex A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:43:18Z cellular_component owl:Class
GO:0001958 biolink:NamedThing endochondral ossification Replacement ossification wherein bone tissue replaces cartilage. got7fsn_ti Wikipedia:Endochondral_ossification biological_process owl:Class
GO:0036075 biolink:NamedThing replacement ossification Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation. got7fsn_ti indirect ossification bf 2011-12-19T01:53:16Z biological_process owl:Class
GO:0071063 biolink:NamedThing sensory perception of wind The series of events required for an organism to receive sensory mechanical stimulus resulting from air flow, convert it to a molecular signal, and recognize and characterize the signal. got7fsn_ti perception of wind|sensory perception of air flow mah 2009-11-04T02:40:34Z biological_process owl:Class
GO:0034028 biolink:NamedThing 5-(carboxyamino)imidazole ribonucleotide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole + ATP + bicarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 3 H(+) + phosphate. got7fsn_ti PurK|N5-CAIR synthetase activity|N5-carboxyaminoimidazole ribonucleotide synthetase activity|5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming) activity KEGG_REACTION:R07404|EC:6.3.4.18|RHEA:19317|MetaCyc:RXN0-742 molecular_function owl:Class
GO:0061419 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. got7fsn_ti dph 2012-01-23T01:07:43Z biological_process owl:Class
GO:0018798 biolink:NamedThing gallate decarboxylase activity Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol. got7fsn_ti gallate carboxy-lyase (pyrogallol-forming)|gallic acid decarboxylase activity|gallate carboxy-lyase activity RHEA:12749|MetaCyc:GALLATE-DECARBOXYLASE-RXN|EC:4.1.1.59|UM-BBD_reactionID:r0005|KEGG_REACTION:R03247 molecular_function owl:Class
GO:0001760 biolink:NamedThing aminocarboxymuconate-semialdehyde decarboxylase activity Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2). got7fsn_ti 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity|2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity|alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity|picolinic acid decarboxylase activity|picolinic acid carboxylase activity|ACMSD activity|2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)|alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity EC:4.1.1.45|MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN|KEGG_REACTION:R04323|RHEA:16557 molecular_function owl:Class
GO:0018703 biolink:NamedThing 2,4-dichlorophenoxyacetate dehalogenase activity Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate. got7fsn_ti UM-BBD_reactionID:r0280 molecular_function owl:Class
GO:0008488 biolink:NamedThing gamma-glutamyl carboxylase activity Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide. got7fsn_ti Reactome:R-HSA-159819|Reactome:R-HSA-159761|Reactome:R-HSA-159752|Reactome:R-HSA-163820|EC:4.1.1.90|RHEA:45140|Reactome:R-HSA-159795|Reactome:R-HSA-159803|Reactome:R-HSA-163810|Reactome:R-HSA-9673231|Reactome:R-HSA-159826|Reactome:R-HSA-6807214 molecular_function owl:Class
GO:0050023 biolink:NamedThing L-fuconate dehydratase activity Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O. got7fsn_ti L-fuconate hydratase activity|L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming)|L-fuconate hydro-lyase activity KEGG_REACTION:R03688|EC:4.2.1.68|RHEA:22772|MetaCyc:L-FUCONATE-HYDRATASE-RXN molecular_function owl:Class
GO:0036434 biolink:NamedThing nitronate monooxygenase (FMN-linked) activity Catalysis of the reaction: ethylnitronate + FMNH(2) + O(2) = acetaldehyde + FMN + H(2)O + H(+) + nitrite. got7fsn_ti bf 2013-09-16T16:20:13Z KEGG_REACTION:R00025|RHEA:26458 molecular_function owl:Class
GO:0018399 biolink:NamedThing peptidyl-phenylalanine bromination to L-4'-bromophenylalanine The bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine. got7fsn_ti RESID:AA0176 biological_process owl:Class
GO:0036130 biolink:NamedThing prostaglandin H2 endoperoxidase reductase activity Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate). got7fsn_ti PGH2 9,11-endoperoxidase|PGH2 9-,11-endoperoxide reductase bf 2012-03-05T09:25:03Z KEGG_REACTION:R02264|Reactome:R-HSA-2161549|RHEA:45312 molecular_function owl:Class
GO:0034873 biolink:NamedThing thioacetamide S-oxygenase activity Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O. got7fsn_ti UM-BBD_reactionID:r1312 molecular_function owl:Class
GO:0060873 biolink:NamedThing anterior semicircular canal development The progession of the anterior semicircular canal from its initial formation to the mature structure. got7fsn_ti dph 2009-08-13T09:39:49Z biological_process owl:Class
GO:0043956 biolink:NamedThing 3-hydroxypropionyl-CoA dehydratase activity Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O. got7fsn_ti acetyl-coenzyme A synthetase|AMP-dependent synthetase and ligase|3-hydroxy propionyl-CoA dehydratase activity|enoyl-CoA hydratase/isomerase|acetyl-coenzyme A synthetase/GroES-like domain|AMP-dependent synthetase and ligase:Enoyl-CoA hydratase/isomerase Note that this function is one of the activities of the trifunctional enzyme propionyl-coenzyme A synthase. See PMID:11821399. MetaCyc:RXN-6383|RHEA:26518|EC:4.2.1.116 molecular_function owl:Class
GO:0071115 biolink:NamedThing alpha5-beta1 integrin-endostatin complex A protein complex that consists of an alpha5-beta1 integrin complex bound to endostatin, the NC1 domain of the alpha1 chain of type XVIII collagen. got7fsn_ti ITGA5-ITGB1-CAL4A3 complex mah 2009-11-13T02:18:57Z cellular_component owl:Class
GO:0047254 biolink:NamedThing 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity Catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP. got7fsn_ti uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase activity|UDP-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity|UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity MetaCyc:2.4.1.202-RXN|EC:2.4.1.202|RHEA:15541 molecular_function owl:Class
GO:0050549 biolink:NamedThing cyclohexyl-isocyanide hydratase activity Catalysis of the reaction: N-cyclohexylformamide + H(+) = cyclohexyl isocyanide + H(2)O. got7fsn_ti isonitrile hydratase activity|N-cyclohexylformamide hydro-lyase (cyclohexyl-isocyanide-forming)|N-cyclohexylformamide hydro-lyase activity KEGG_REACTION:R05771|UM-BBD_reactionID:r1029|MetaCyc:4.2.1.103-RXN|RHEA:18197|EC:4.2.1.103 molecular_function owl:Class
GO:0034688 biolink:NamedThing integrin alphaM-beta2 complex An integrin complex that comprises one alphaM subunit and one beta2 subunit. got7fsn_ti alphaM-beta2 integrin complex|Itgam-Itgb2 complex cellular_component owl:Class
GO:0051802 biolink:NamedThing regulation of cytolysis in other organism involved in symbiotic interaction Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti regulation of cytolysis of cells in other organism involved in symbiotic interaction|regulation of cytolysis of cells in other organism during symbiotic interaction biological_process owl:Class
GO:0070974 biolink:NamedThing POU domain binding Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors. got7fsn_ti mah 2009-10-02T12:53:02Z molecular_function owl:Class
GO:0035885 biolink:NamedThing exochitinase activity Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain. got7fsn_ti bf 2011-06-08T11:13:58Z MetaCyc:RXN-12309|RHEA:50672 molecular_function owl:Class
GO:0004607 biolink:NamedThing phosphatidylcholine-sterol O-acyltransferase activity Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. got7fsn_ti LCAT activity|phospholipid--cholesterol acyltransferase activity|lecithin:cholesterol acyltransferase activity|phosphatidylcholine:sterol O-acyltransferase activity|LCAT (lecithin-cholesterol acyltransferase)|lecithin--cholesterol acyltransferase activity RHEA:21204|MetaCyc:2.3.1.43-RXN|Reactome:R-HSA-264695|EC:2.3.1.43 molecular_function owl:Class
GO:0050147 biolink:NamedThing nucleoside ribosyltransferase activity Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1. got7fsn_ti nucleoside N-ribosyltransferase activity|nucleoside:purine(pyrimidine) D-ribosyltransferase activity MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN|EC:2.4.2.5 molecular_function owl:Class
GO:0062045 biolink:NamedThing L-lysine alpha-aminotransferase Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine. got7fsn_ti dph 2018-05-11T12:13:57Z molecular_function owl:Class
GO:0046556 biolink:NamedThing alpha-L-arabinofuranosidase activity Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. got7fsn_ti polysaccharide alpha-L-arabinofuranosidase activity|alpha-L-arabinosidase activity|alpha-arabinosidase activity|alpha-L-arabinofuranoside arabinofuranohydrolase activity|L-arabinosidase activity|arabinosidase activity|alpha-L-arabinofuranoside hydrolase activity|alpha-arabinofuranosidase activity|alpha-L-arabinanase activity|arabinofuranosidase activity|alpha-N-arabinofuranosidase activity EC:3.2.1.55|MetaCyc:3.2.1.55-RXN molecular_function owl:Class
GO:0047592 biolink:NamedThing 5-pyridoxate dioxygenase activity Catalysis of the reaction: 5-pyridoxate + NADPH + O(2) = 2-(acetamidomethylene)-3-(hydroxymethyl)succinate) + NADP(+). got7fsn_ti 5-pyridoxate oxidase activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.14.12.5. EC:1.14.13.241|KEGG_REACTION:R04570|RHEA:11152|MetaCyc:5-PYRIDOXATE-DIOXYGENASE-RXN molecular_function owl:Class
GO:0030777 biolink:NamedThing (S)-scoulerine 9-O-methyltransferase activity Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity|S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity EC:2.1.1.117|RHEA:23808|KEGG_REACTION:R03835|MetaCyc:2.1.1.117-RXN molecular_function owl:Class
GO:0030848 biolink:NamedThing threo-3-hydroxyaspartate ammonia-lyase activity Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate. got7fsn_ti threo-3-hydroxyaspartate dehydratase activity|threo-3-hydroxy-L-aspartate ammonia-lyase activity|threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)|3-hydroxyaspartate dehydratase activity|L-threo-3-hydroxyaspartate dehydratase activity RHEA:12424|KEGG_REACTION:R05758|MetaCyc:4.3.1.16-RXN|EC:4.3.1.16 molecular_function owl:Class
GO:0050102 biolink:NamedThing cellodextrin phosphorylase activity Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. got7fsn_ti 1,4-beta-D-oligo-D-glucan:phosphate alpha-D-glucosyltransferase activity|beta-1,4-oligoglucan:orthophosphate glucosyltransferase activity MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN|RHEA:23024|EC:2.4.1.49 molecular_function owl:Class
GO:0035650 biolink:NamedThing AP-1 adaptor complex binding Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). got7fsn_ti bf 2011-01-25T10:58:52Z molecular_function owl:Class
GO:0036118 biolink:NamedThing hyaluranon cable assembly A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan. got7fsn_ti HA cable assembly bf 2012-02-16T11:06:58Z biological_process owl:Class
GO:0070217 biolink:NamedThing transcription factor TFIIIB complex assembly The aggregation, arrangement and bonding together of a set of components to form a transcription factor TFIIIB complex. got7fsn_ti TFIIIB assembly biological_process owl:Class
GO:0046066 biolink:NamedThing dGDP metabolic process The chemical reactions and pathways involving dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate). got7fsn_ti dGDP metabolism biological_process owl:Class
GO:0060879 biolink:NamedThing semicircular canal fusion Creation of the central hole of the semicircular canal by sealing the edges of the pouch that forms during the process of semicircular canal formation. got7fsn_ti dph 2009-08-13T10:05:51Z biological_process owl:Class
GO:0019325 biolink:NamedThing anaerobic fructose catabolic process The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen. got7fsn_ti anaerobic fructose catabolism|anaerobic fructose degradation|anaerobic fructose breakdown MetaCyc:ANAEROFRUCAT-PWY biological_process owl:Class
GO:0019317 biolink:NamedThing fucose catabolic process The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose). got7fsn_ti fucose catabolism|fucose breakdown|fucose degradation MetaCyc:FUCCAT-PWY biological_process owl:Class
GO:0050405 biolink:NamedThing [acetyl-CoA carboxylase] kinase activity Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate. got7fsn_ti ACK2|I-peptide kinase activity|acetyl-CoA carboxylase kinase-2 activity|ACK3|STK5|acetyl-coenzyme A carboxylase kinase activity|acetyl coenzyme A carboxylase kinase (phosphorylating) activity|acetyl-CoA carboxylase kinase 2 activity|acetyl-CoA carboxylase kinase activity|acetyl-CoA carboxylase bound kinase activity|acetyl-CoA carboxylase kinase (AMP-activated) activity|acetyl-CoA carboxylase kinase (cAMP-independent) activity|AMPK|ATP:acetyl-CoA carboxylase phosphotransferase activity|acetyl-CoA carboxylase kinase-3 (AMP-activated) activity MetaCyc:2.7.11.27-RXN|RHEA:20333|EC:2.7.11.27 molecular_function owl:Class
GO:0050160 biolink:NamedThing orsellinate-depside hydrolase activity Catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+). got7fsn_ti lecanorate hydrolase activity KEGG_REACTION:R00054|RHEA:19549|MetaCyc:ORSELLINATE-DEPSIDE-HYDROLASE-RXN|EC:3.1.1.40 molecular_function owl:Class
GO:0006398 biolink:NamedThing mRNA 3'-end processing by stem-loop binding and cleavage Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine. got7fsn_ti histone mRNA 3' end processing biological_process owl:Class
GO:0031722 biolink:NamedThing hemoglobin beta binding Binding to a hemoglobin beta chain. got7fsn_ti molecular_function owl:Class
GO:0060110 biolink:NamedThing basal layer of collagen and cuticulin-based cuticle extracellular matrix The layer of cuticle most closely apposed to the hypodermal cells. The morphology of the basal layer varies with life stage. In adult C. elegans animals, the basal layers is comprised of three sublayers: two fibrous layers whose fibers run in clockwise and counter-clockwise directions meeting one another at a 60 degree angle, and an amorphous basal layer that lies underneath the fibrous layers and directly contacts the hypodermis. In C. elegans dauer and L1 larval stage animals, the basal layer is characterized by a striated pattern that appears to derive from interwoven laminae. An example of this component is found in Caenorhabditis elegans. got7fsn_ti basal layer of collagen and cuticulin-based exoskeleton extracellular matrix cellular_component owl:Class
GO:0071540 biolink:NamedThing eukaryotic translation initiation factor 3 complex, eIF3e An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e. got7fsn_ti eIF3e-containing eukaryotic translation initiation factor 3 complex mah 2010-01-12T02:20:24Z cellular_component owl:Class
GO:0050291 biolink:NamedThing sphingosine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. got7fsn_ti dihydroceramide synthase activity|acyl-CoA:sphingosine N-acyltransferase activity|ceramide synthetase activity|sphingosine acyltransferase activity|ceramide synthase activity Reactome:R-HSA-428185|MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN|RHEA:23768|EC:2.3.1.24 molecular_function owl:Class
GO:0102189 biolink:NamedThing 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-formyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + 2 H2O. got7fsn_ti MetaCyc:RXN-11957 molecular_function owl:Class
GO:0019803 biolink:NamedThing peptidyl-aspartic acid carboxylation The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid. got7fsn_ti RESID:AA0304 biological_process owl:Class
GO:0102967 biolink:NamedThing 10-hydroxygeraniol oxidoreductase activity Catalysis of the reaction: (6E)-8-hydroxygeraniol + NADP <=> (6E)-8-hydroxygeranial + NADPH + H+. got7fsn_ti MetaCyc:RXN-9367|RHEA:32607 molecular_function owl:Class
GO:0140627 biolink:NamedThing ubiquitin-dependent protein catabolic process via the C-end degron rule pathway The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the DesCEND (destruction via C-end degron) pathway. In the DesCEND pathway, C-terminal residues (C-end degrons) in substrates are recognized by Cul2-RING and Cul4-RING E3 ligases, whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation. C-end degrons can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. got7fsn_ti DesCEND https://github.com/geneontology/go-ontology/issues/21184 pg 2021-03-24T07:30:47Z biological_process owl:Class
GO:0030115 biolink:NamedThing S-layer A crystalline protein layer surrounding some bacteria. got7fsn_ti Wikipedia:S-layer cellular_component owl:Class
GO:0050336 biolink:NamedThing thioethanolamine S-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA. got7fsn_ti thioltransacetylase B activity|thioethanolamine acetyltransferase activity|acetyl-CoA:2-aminoethanethiol S-acetyltransferase activity|acetyl-CoA:thioethanolamine S-acetyltransferase activity EC:2.3.1.11|RHEA:23280|MetaCyc:THIOETHANOLAMINE-S-ACETYLTRANSFERASE-RXN|KEGG_REACTION:R03668 molecular_function owl:Class
GO:0071795 biolink:NamedThing K11-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 11 in the target protein. got7fsn_ti mah 2010-09-02T02:11:41Z molecular_function owl:Class
GO:0047462 biolink:NamedThing phenylalanine racemase (ATP-hydrolyzing) activity Catalysis of the reaction: L-phenylalanine + ATP + H(2)O = D-phenylalanine + AMP + diphosphate + 2 H(+). got7fsn_ti phenylalanine racemase (adenosine triphosphate-hydrolysing)|phenylalanine racemase (ATP-hydrolysing)|phenylalanine racemase activity|gramicidin S synthetase I MetaCyc:5.1.1.11-RXN|RHEA:20201|KEGG_REACTION:R00686|EC:5.1.1.11 molecular_function owl:Class
GO:0009899 biolink:NamedThing ent-kaurene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate. got7fsn_ti ent-copalyl-diphosphate diphosphate-lyase (cyclizing)|ent-kaurene synthetase B activity|ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)|ent-kaurene synthase B activity RHEA:22220|EC:4.2.3.19|KEGG_REACTION:R05092|MetaCyc:4.2.3.19-RXN molecular_function owl:Class
GO:0016277 biolink:NamedThing [myelin basic protein]-arginine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine. got7fsn_ti myelin basic protein-arginine N-methyltransferase activity|S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity|myelin basic protein methylase activity|protein methylase I activity|myelin basic protein methylase I|S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity molecular_function owl:Class
GO:0052791 biolink:NamedThing 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain. got7fsn_ti 2-keto-3-deoxynononic acid sialidase activity ai 2011-10-04T04:53:49Z molecular_function owl:Class
GO:0102969 biolink:NamedThing 10-oxogeraniol oxidoreductase activity Catalysis of the reaction: (6E)-8-oxogeraniol + NADP <=> (6E)-8-oxogeranial + NADPH + H+. got7fsn_ti RHEA:32615|MetaCyc:RXN-9370 molecular_function owl:Class
GO:0033760 biolink:NamedThing 2'-deoxymugineic-acid 2'-dioxygenase activity Catalysis of the reaction: 2'-deoxymugineate + 2-oxoglutarate + O(2) = CO(2) + H(+) + mugineate + succinate. got7fsn_ti IDS3|2'-deoxymugineic acid,2-oxoglutarate:oxygen oxidoreductase (2-hydroxylating) activity KEGG_REACTION:R07185|MetaCyc:1.14.11.24-RXN|RHEA:12200|EC:1.14.11.24 molecular_function owl:Class
GO:0018161 biolink:NamedThing dipyrrin biosynthetic process The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group. got7fsn_ti dipyrrin anabolism|dipyrromethane biosynthesis|dipyrrin biosynthesis|dipyrromethane biosynthetic process|dipyrrin synthesis|dipyrrin formation biological_process owl:Class
GO:0033812 biolink:NamedThing 3-oxoadipyl-CoA thiolase activity Catalysis of the reaction: succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA. got7fsn_ti succinyl-CoA:acetyl-CoA C-succinyltransferase activity MetaCyc:RXN-3641|RHEA:19481|EC:2.3.1.174 molecular_function owl:Class
GO:0043781 biolink:NamedThing cobalt-factor II C20-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III. got7fsn_ti cobalt-factor II C20 methyltransferase activity|cobalt-precorrin-2 C(20)-methyltransferase activity|S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase activity|CbiL MetaCyc:RXN-8760|RHEA:17997|EC:2.1.1.151 molecular_function owl:Class
GO:0010383 biolink:NamedThing cell wall polysaccharide metabolic process The chemical reactions and pathways involving cell wall polysaccharides. got7fsn_ti biological_process owl:Class
GO:0008349 biolink:NamedThing MAP kinase kinase kinase kinase activity Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. got7fsn_ti MAP4K activity|MAPKKKK Reactome:R-HSA-936991|Reactome:R-HSA-177692|Reactome:R-HSA-9645442 molecular_function owl:Class
GO:0051799 biolink:NamedThing negative regulation of hair follicle development Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle development. got7fsn_ti down-regulation of hair follicle development|downregulation of hair follicle development|inhibition of hair follicle development|down regulation of hair follicle development biological_process owl:Class
GO:0021812 biolink:NamedThing neuronal-glial interaction involved in cerebral cortex radial glia guided migration The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration. got7fsn_ti neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:0003282 biolink:NamedThing ventricular septum intermedium development The progression of the ventricular septum intermedium over time, from its formation to the mature structure. got7fsn_ti dph 2009-10-20T10:09:53Z biological_process owl:Class
GO:0047503 biolink:NamedThing (-)-borneol dehydrogenase activity Catalysis of the reaction: (-)-borneol + NAD(+) = (1S,4S)-camphor + H(+) + NADH. got7fsn_ti (-)-borneol:NAD+ oxidoreductase activity RHEA:22128|EC:1.1.1.227|MetaCyc:--BORNEOL-DEHYDROGENASE-RXN|KEGG_REACTION:R02945 molecular_function owl:Class
GO:0051688 biolink:NamedThing maintenance of plastid location Any process in which a plastid is maintained in a specific location within a cell and prevented from moving elsewhere. got7fsn_ti maintenance of plastid localization biological_process owl:Class
GO:0140642 biolink:NamedThing meiotic spindle formation (spindle phase two) The spindle organization process in which the spindle is maintained at a constant length during meiotic metaphase. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21349 pg 2021-05-11T08:18:16Z biological_process owl:Class
GO:0090306 biolink:NamedThing meiotic spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis. got7fsn_ti spindle assembly involved in meiosis|meiotic spindle assembly https://github.com/geneontology/go-ontology/issues/21349 tb 2010-04-09T11:21:56Z biological_process owl:Class
GO:0005519 biolink:NamedThing cytoskeletal regulatory protein binding Binding to a protein involved in modulating the reorganization of the cytoskeleton. got7fsn_ti molecular_function owl:Class
GO:0050452 biolink:NamedThing CoA-glutathione reductase activity Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+. got7fsn_ti CoA-glutathione reductase (NADPH) activity|NADPH2:CoA-glutathione oxidoreductase activity|NADPH:CoA-glutathione oxidoreductase activity|coenzyme A glutathione disulfide reductase activity|coenzyme A disulfide-glutathione reductase activity|glutathione:NADP+ oxidoreductase (CoA-acylating)|NADPH-dependent coenzyme A-SS-glutathione reductase activity RHEA:14617|MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN|EC:1.8.1.10 molecular_function owl:Class
GO:0000448 biolink:NamedThing cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. got7fsn_ti cleavage at C2|cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0000490 biological_process owl:Class
GO:0140566 biolink:NamedThing epigenetic reader A transcription regulator that recognizes epigenetic marks such as methylated cytosines in CpG islands and modified histones, and modulates the accessibility of cis-regulatory regions to the transcription machinery. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20551 pg 2020-12-11T13:25:49Z molecular_function owl:Class
GO:0018460 biolink:NamedThing cyclohexanol dehydrogenase activity Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+. got7fsn_ti cyclohexanol:NAD+ oxidoreductase activity EC:1.1.1.245|MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN|RHEA:10044|UM-BBD_reactionID:r0165 molecular_function owl:Class
GO:0032762 biolink:NamedThing mast cell cytokine production Any process that contributes to cytokine production by a mast cell. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. biological_process owl:Class
GO:0047268 biolink:NamedThing galactinol-raffinose galactosyltransferase activity Catalysis of the reaction: raffinose + 1-alpha-D-galactosyl-myo-inositol = stachyose + myo-inositol. got7fsn_ti stachyose synthetase activity|alpha-D-(1->3)-galactosyl-myo-inositol:raffinose galactosyltransferase activity MetaCyc:2.4.1.67-RXN|EC:2.4.1.67|RHEA:20776 molecular_function owl:Class
GO:0035059 biolink:NamedThing RCAF complex A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4. got7fsn_ti replication-coupling assembly factor complex cellular_component owl:Class
GO:1900127 biolink:NamedThing positive regulation of hyaluronan biosynthetic process Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process. got7fsn_ti activation of hyaluronan synthesis|up-regulation of hyaluronan biosynthesis|up-regulation of hyaluronan synthesis|upregulation of hyaluronan formation|upregulation of hyaluronan synthesis|upregulation of hyaluronan anabolism|up regulation of hyaluronan formation|activation of hyaluronan biosynthetic process|positive regulation of hyaluronan biosynthesis|up regulation of hyaluronan biosynthetic process|up regulation of hyaluronan biosynthesis|activation of hyaluronan biosynthesis|upregulation of hyaluronan biosynthetic process|up regulation of hyaluronan synthesis|upregulation of hyaluronan biosynthesis|up-regulation of hyaluronan biosynthetic process|up-regulation of hyaluronan anabolism|positive regulation of hyaluronan formation|activation of hyaluronan formation|up regulation of hyaluronan anabolism|activation of hyaluronan anabolism|positive regulation of hyaluronan anabolism|up-regulation of hyaluronan formation|positive regulation of hyaluronan synthesis yaf 2012-02-23T01:09:33Z biological_process owl:Class
GO:0071915 biolink:NamedThing protein-lysine lysylation The addition of lysine group to a lysine residue in a protein, producing N6-(lysyl)-L-lysine. This modification is observed in, and is probably unique to, translation elongation factor P (EF-P). got7fsn_ti protein amino acid lysylation mah 2010-09-24T10:01:57Z biological_process owl:Class
GO:0047197 biolink:NamedThing triglyceride-sterol O-acyltransferase activity Catalysis of the reaction: a 3-beta-hydroxysterol + triacylglycerol = a 3-beta-hydroxysterol ester + 1,2-diacylglycerol. got7fsn_ti triacylglycerol:sterol acyltransferase activity|triacylglycerol:3beta-hydroxysterol O-acyltransferase activity|triacylglycerol-sterol O-acyltransferase activity EC:2.3.1.77|RHEA:16897|MetaCyc:2.3.1.77-RXN molecular_function owl:Class
GO:0033270 biolink:NamedThing paranode region of axon An axon part that is located adjacent to the nodes of Ranvier and surrounded by lateral loop portions of myelin sheath. got7fsn_ti paranode NIF_Subcellular:sao234066064|NIF_Subcellular:sao936144858 cellular_component owl:Class
GO:0017005 biolink:NamedThing 3'-tyrosyl-DNA phosphodiesterase activity Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. got7fsn_ti See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. molecular_function owl:Class
GO:0047316 biolink:NamedThing glutamine-phenylpyruvate transaminase activity Catalysis of the reaction: keto-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine. got7fsn_ti glutamine-phenylpyruvate aminotransferase activity|glutamine--phenylpyruvate aminotransferase activity|glutamine transaminase K activity|L-glutamine:phenylpyruvate aminotransferase activity KEGG_REACTION:R01375|RHEA:17593|MetaCyc:2.6.1.64-RXN|EC:2.6.1.64 molecular_function owl:Class
GO:0047273 biolink:NamedThing galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide = UDP + beta-N-acetyl-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide. got7fsn_ti UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase activity|UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase activity|UDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase activity|uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase activity|globoside synthetase activity|globoside synthase activity|globotriosylceramide beta-1,6-N-acetylgalactosaminyltransferase activity|beta3GalNAc-T1|UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase activity|galactosylgalactosylglucosylceramide beta-D- activity|beta-3GalNAc-T1 activity|globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase activity GO:0047226 MetaCyc:2.4.1.79-RXN|Reactome:R-HSA-8878914|RHEA:22252|EC:2.4.1.79 molecular_function owl:Class
GO:0070219 biolink:NamedThing cellular sulfide ion homeostasis Any process involved in the maintenance of an internal steady state of sulfide ions at the level of a cell. got7fsn_ti cellular sulphide homeostasis|cellular sulfide homeostasis|cellular sulphide ion homeostasis biological_process owl:Class
GO:0035683 biolink:NamedThing memory T cell extravasation The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive. got7fsn_ti memory T-cell extravasation bf 2011-02-23T01:10:02Z biological_process owl:Class
GO:0018719 biolink:NamedThing 6-aminohexanoate transaminase activity Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate. got7fsn_ti UM-BBD_reactionID:r0449|MetaCyc:R562-RXN molecular_function owl:Class
GO:0047869 biolink:NamedThing dimethylpropiothetin dethiomethylase activity Catalysis of the reaction: S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide + H(+). got7fsn_ti S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase activity|desulfhydrase activity|S,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (acrylate-forming) EC:4.4.1.3|KEGG_REACTION:R02574|MetaCyc:DIMETHYLPROPIOTHETIN-DETHIOMETHYLASE-RXN|RHEA:19965 molecular_function owl:Class
GO:0071051 biolink:NamedThing polyadenylation-dependent snoRNA 3'-end processing Any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA. got7fsn_ti poly(A)-dependent snoRNA 3'-end processing krc 2009-08-25T03:47:24Z biological_process owl:Class
GO:0043177 biolink:NamedThing organic acid binding Binding to an organic acid, any acidic compound containing carbon in covalent linkage. got7fsn_ti molecular_function owl:Class
GO:0051064 biolink:NamedThing TTP reductase activity Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. got7fsn_ti TTP reduction EC:1.17.4.- molecular_function owl:Class
GO:0061360 biolink:NamedThing optic chiasma development The developmental process pertaining to the progression of the optic chiasm from its initial formation to the mature structure. The process begins when the pathfinding of the axons of the developing optic nerve cause some axons to cross at the midline of the brain and ends when the axons are mature. got7fsn_ti optic chiasm development dph 2010-10-13T08:00:29Z biological_process owl:Class
GO:0043431 biolink:NamedThing 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine. got7fsn_ti 3-demethylubiquinone-9 3-methyltransferase activity|2-octaprenyl-6-hydroxy phenol methylase activity MetaCyc:2.1.1.64-RXN molecular_function owl:Class
GO:0045785 biolink:NamedThing positive regulation of cell adhesion Any process that activates or increases the frequency, rate or extent of cell adhesion. got7fsn_ti up regulation of cell adhesion|upregulation of cell adhesion|stimulation of cell adhesion|activation of cell adhesion|up-regulation of cell adhesion biological_process owl:Class
GO:0102441 biolink:NamedThing syringetin 7-O-methyltransferase activity Catalysis of the reaction: syringetin(1-) + S-adenosyl-L-methionine <=> 7,3',5'-trimethylmyricetin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13919 molecular_function owl:Class
GO:0140443 biolink:NamedThing mitochondrion-plasma membrane adaptor activity The binding activity of a molecule that brings together a mitochondrion and a plasma membrane either via membrane lipid binding or by interacting with a mitochondrial outer membrane protein, to establish or maintain the localization of the mitochondrion. got7fsn_ti plasma membrane-mitochondrion adaptor activity|mitochondrion plasma membrane adaptor activity|mitochondrion plasma membrane tether activity|plasma membrane-mitochondrion tether activity https://github.com/geneontology/go-ontology/pull/19140 pg 2020-03-24T13:11:20Z molecular_function owl:Class
GO:0060240 biolink:NamedThing negative regulation of signal transduction involved in conjugation with cellular fusion Any process that decreases the rate, frequency or extent of the series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion. got7fsn_ti biological_process owl:Class
GO:0033816 biolink:NamedThing diaminobutyrate acetyltransferase activity Catalysis of the reaction: L-2,4-diaminobutyrate + acetyl-CoA = N(4)-acetyl-L-2,4-diaminobutyrate + CoA + H(+). got7fsn_ti DABA acetyltransferase activity|2,4-diaminobutanoate acetyltransferase activity|DAB acetyltransferase activity|acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase activity|DABAcT|acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase activity|L-2,4-diaminobutyrate acetyltransferase activity|diaminobutyric acid acetyltransferase activity|L-2,4-diaminobutanoate acetyltransferase activity|EctA EC:2.3.1.178|MetaCyc:R102-RXN|KEGG_REACTION:R06978|RHEA:16901 molecular_function owl:Class
GO:0103025 biolink:NamedThing alpha-amylase activity (releasing maltohexaose) Catalysis of the reaction: n H2O + a 1,4-alpha-D-glucan = alpha-maltohexaose + a 1,4-alpha-D-glucan. got7fsn_ti MetaCyc:RXN0-5181|EC:3.2.1.1 molecular_function owl:Class
GO:0005130 biolink:NamedThing granulocyte colony-stimulating factor receptor binding Binding to a granulocyte colony-stimulating factor receptor. got7fsn_ti GC-SF receptor ligand|granulocyte colony-stimulating factor|granulocyte colony stimulating factor receptor binding|granulocyte colony-stimulating factor receptor ligand|G-CSF receptor ligand molecular_function owl:Class
GO:0052609 biolink:NamedThing 4-ketotorulene 3-hydroxylase activity Catalysis of the reaction: 4-ketotorulene + a reduced electron acceptor + oxygen = 3-hydroxy-4-ketotorulene + an oxidized electron acceptor + H2O. got7fsn_ti carotene beta-ring hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity|beta-carotene hydroxylase activity MetaCyc:RXN-8218 molecular_function owl:Class
GO:0072576 biolink:NamedThing liver morphogenesis The process in which the anatomical structures of the liver are generated and organized. got7fsn_ti mah 2011-02-02T03:41:30Z biological_process owl:Class
GO:0070084 biolink:NamedThing protein initiator methionine removal The protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein. got7fsn_ti removal of initiator methionine from protein biological_process owl:Class
GO:0097206 biolink:NamedThing nephrocyte filtration The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm. got7fsn_ti pr 2012-01-03T03:13:31Z biological_process owl:Class
GO:0047191 biolink:NamedThing 1-alkylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA. got7fsn_ti acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase activity EC:2.3.1.63|MetaCyc:2.3.1.63-RXN|RHEA:23992 molecular_function owl:Class
GO:0008336 biolink:NamedThing gamma-butyrobetaine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate. got7fsn_ti g-butyrobetaine dioxygenase activity|gamma-BBH activity|gamma-butyrobetaine,2-oxoglutarate dioxygenase activity|gamma-butyrobetaine hydroxylase activity|4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)|alpha-butyrobetaine hydroxylase activity|butyrobetaine hydroxylase activity KEGG_REACTION:R02397|EC:1.14.11.1|Reactome:R-HSA-71261|MetaCyc:1.14.11.1-RXN|RHEA:24028 molecular_function owl:Class
GO:0102506 biolink:NamedThing cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-beta-D-glucoside betaine + 1-O-feruloyl-beta-D-glucose = cyanin betaine + ferulate + H+. got7fsn_ti EC:2.4.1.299|MetaCyc:RXN-14432 molecular_function owl:Class
GO:0034665 biolink:NamedThing integrin alpha1-beta1 complex An integrin complex that comprises one alpha1 subunit and one beta1 subunit. got7fsn_ti ITGA1-ITGB1 complex|VLA-1 complex|alpha1-beta1 integrin complex cellular_component owl:Class
GO:0050512 biolink:NamedThing lactosylceramide 4-alpha-galactosyltransferase activity Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP. got7fsn_ti Gal-beta-(1,4)-Glc-beta-1-Cer alpha-(1,4)-galactosyltransferase activity|histo-blood group Pk UDP-galactose|histo-blood group P(k) UDP-galactose activity|Gal-beta-1,4-Glc-beta-1-Cer alpha-1,4-galactosyltransferase activity|UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase activity|lactosylceramide 4-a-galactosyltransferase activity|globotriaosylceramide/CD77 synthase activity RHEA:11924|MetaCyc:2.4.1.228-RXN|EC:2.4.1.228 molecular_function owl:Class
GO:0018219 biolink:NamedThing peptidyl-cysteine S-acetylation The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine. got7fsn_ti RESID:AA0056 biological_process owl:Class
GO:0034917 biolink:NamedThing 2-methylhex-2-enoyl-CoA hydratase activity Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA. got7fsn_ti UM-BBD_reactionID:r0929 molecular_function owl:Class
GO:0033919 biolink:NamedThing glucan 1,3-alpha-glucosidase activity Catalysis of the hydrolysis of terminal (1->3)-alpha-D-glucosidic links in 1,3-alpha-D-glucans. got7fsn_ti glucosidase II activity|exo-1,3-alpha-glucanase activity|1,3-alpha-D-glucan 3-glucohydrolase activity EC:3.2.1.84|Reactome:R-HSA-9683663|MetaCyc:3.2.1.84-RXN|Reactome:R-HSA-532667|Reactome:R-HSA-9694364|Reactome:R-HSA-548890 molecular_function owl:Class
GO:0120147 biolink:NamedThing Formylglycine-generating oxidase activity Catalysis of the reaction: A [sulfatase]-L-cysteine + O(2) + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H(2)O. got7fsn_ti krc 2018-04-06T15:38:52Z EC:1.8.3.7|RHEA:51152|MetaCyc:RXN-16226 molecular_function owl:Class
GO:0048159 biolink:NamedThing primary oocyte stage The stage in oogenesis when the oocyte has a nucleus slightly larger than those of the adjacent cells and is surrounded by a layer of loose squamous epithelial cells. got7fsn_ti mammalian oogenesis stage 2 biological_process owl:Class
GO:0046509 biolink:NamedThing 1,2-diacylglycerol 3-beta-galactosyltransferase activity Catalysis of the reaction: 1,2-diacyl-sn-glycerol + UDP-D-galactose = 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol + H(+) + UDP. got7fsn_ti 1beta-MGDG|UDP-galactose:diacylglycerol galactosyltransferase activity|UDP-galactose-diacylglyceride galactosyltransferase activity|1-beta-MGDG activity|UDPgalactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase activity|uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase activity|UDP galactose-1,2-diacylglycerol galactosyltransferase activity|UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase activity|monogalactosyldiacylglycerol synthase activity|MGDG synthase activity KEGG_REACTION:R02691|RHEA:14945|MetaCyc:2.4.1.46-RXN|EC:2.4.1.46 molecular_function owl:Class
GO:0008031 biolink:NamedThing eclosion hormone activity The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis. got7fsn_ti molecular_function owl:Class
GO:0047493 biolink:NamedThing ceramide cholinephosphotransferase activity Catalysis of the reaction: CDP-choline + ceramide = CMP + H(+) + sphingomyelin. got7fsn_ti CDP-choline:N-acylsphingosine cholinephosphotransferase activity|phosphorylcholine-ceramide transferase activity EC:2.7.8.3|KEGG_REACTION:R01891|MetaCyc:CERAMIDE-CHOLINEPHOSPHOTRANSFERASE-RXN|RHEA:16273 molecular_function owl:Class
GO:0008775 biolink:NamedThing acetate CoA-transferase activity Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA. got7fsn_ti acetate coenzyme A-transferase activity|butyryl CoA:acetate CoA transferase activity|acyl-CoA:acetate CoA-transferase activity|acetyl-CoA:acetoacetate CoA transferase activity|succinyl-CoA:acetate CoA transferase activity|butyryl coenzyme A transferase activity EC:2.8.3.8|UM-BBD_enzymeID:e0012|Reactome:R-HSA-2066788|RHEA:13381|MetaCyc:ACECOATRANS-RXN molecular_function owl:Class
GO:0090436 biolink:NamedThing leaf pavement cell development The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate. got7fsn_ti tb 2012-07-31T16:08:53Z biological_process owl:Class
GO:0061831 biolink:NamedThing apical ectoplasmic specialization Testis-specific junction between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell. got7fsn_ti apical ES cellular_component owl:Class
GO:0103104 biolink:NamedThing 6-methylthiohexyldesulfoglucosinolate sulfotransferase activity Catalysis of the reaction: 6-methylthiohexyldesulfoglucosinolate + 3'-phosphonato-5'-adenylyl sulfate <=> adenosine 3',5'-bismonophosphate + H+ + 6-methylthiohexylglucosinolate. got7fsn_ti MetaCyc:RXNQT-4331 molecular_function owl:Class
GO:0036027 biolink:NamedThing protein C inhibitor-PLAU complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator. got7fsn_ti serpin A5-PLAU complex|plasma serine protease inhibitor-PLAU complex|protein C inhibitor-urokinase-type plasminogen activator complex|protein C inhibitor-uPA complex|PCI-PLAU complex|protein C inhibitor-U-plasminogen activator complex|SERPINA5-PLAU complex bf 2011-10-19T01:37:03Z cellular_component owl:Class
GO:0071205 biolink:NamedThing protein localization to juxtaparanode region of axon Any process in which a protein is transported to, or maintained at, the juxtaparanode region of an axon. got7fsn_ti protein localisation to juxtaparanode region of axon mah 2009-11-25T01:13:55Z biological_process owl:Class
GO:0097088 biolink:NamedThing interleukin-17F production The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-17F production pr 2011-06-23T11:32:59Z biological_process owl:Class
GO:0072300 biolink:NamedThing positive regulation of metanephric glomerulus development Any process that increases the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros. got7fsn_ti mah 2010-04-09T05:03:41Z biological_process owl:Class
GO:0004382 biolink:NamedThing guanosine-diphosphatase activity Catalysis of the reaction: GDP + H2O = GMP + phosphate. got7fsn_ti GDP phosphohydrolase activity|guanosine diphosphatase activity|guanosine 5'-diphosphatase activity|GDPase activity MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN|RHEA:22156|EC:3.6.1.42 molecular_function owl:Class
GO:0097262 biolink:NamedThing eoxin D4 synthase activity Catalysis of the reaction: eoxin C4 = eoxin D4 + 5-L-glutamyl amino acid. got7fsn_ti pr 2012-03-08T03:01:00Z Reactome:R-HSA-2161945 molecular_function owl:Class
GO:0047521 biolink:NamedThing 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate dehydrogenase activity Catalysis of the reaction: 3alpha,7alpha,12beta-trihydroxy-5beta-cholanate + NADP(+) = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + H(+) + NADPH. got7fsn_ti 12-beta-hydroxysteroid dehydrogenase activity|12beta-hydroxy steroid (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity|12beta-hydroxysteroid:NADP+ 12-oxidoreductase activity|12beta-hydroxysteroid dehydrogenase activity MetaCyc:12-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN|EC:1.1.1.238|KEGG_REACTION:R03495|RHEA:21424 molecular_function owl:Class
GO:0004788 biolink:NamedThing thiamine diphosphokinase activity Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate. got7fsn_ti thiaminokinase activity|ATP:thiamin pyrophosphotransferase activity|thiamin:ATP pyrophosphotransferase activity|thiamine pyrophosphokinase activity|thiamin pyrophosphotransferase activity|TPTase activity|ATP:thiamine diphosphotransferase activity|thiamin diphosphokinase activity|thiamin pyrophosphokinase activity RHEA:11576|Reactome:R-HSA-196761|EC:2.7.6.2|MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN molecular_function owl:Class
GO:0034185 biolink:NamedThing apolipoprotein binding Binding to an apolipoprotein, the protein component of a lipoprotein complex. got7fsn_ti molecular_function owl:Class
CHEBI:39015 biolink:NamedThing got7fsn_ti owl:Class
GO:0005947 biolink:NamedThing mitochondrial alpha-ketoglutarate dehydrogenase complex Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity. got7fsn_ti 2-oxoglutarate dehydrogenase complex cellular_component owl:Class
GO:1902892 biolink:NamedThing positive regulation of root hair elongation Any process that activates or increases the frequency, rate or extent of root hair elongation. got7fsn_ti up regulation of root hair elongation|activation of root hair elongation|upregulation of root hair elongation|up-regulation of root hair elongation als 2014-04-07T13:46:53Z biological_process owl:Class
GO:1905079 biolink:NamedThing regulation of cerebellar neuron development Any process that modulates the frequency, rate or extent of cerebellar neuron development. got7fsn_ti hjd 2016-03-24T19:45:17Z biological_process owl:Class
NCBITaxon:147537 biolink:NamedThing got7fsn_ti owl:Class
GO:1905789 biolink:NamedThing positive regulation of detection of mechanical stimulus involved in sensory perception of touch Any process that activates or increases the frequency, rate or extent of detection of mechanical stimulus involved in sensory perception of touch. got7fsn_ti up regulation of sensory transduction of mechanical stimulus during perception of touch|upregulation of detection of mechanical stimulus involved in sensory perception of touch|up regulation of perception of touch, sensory transduction of mechanical stimulus|up regulation of sensory detection of mechanical stimulus during perception of touch|activation of perception of touch, detection of mechanical stimulus|up-regulation of tactition, sensory detection of mechanical stimulus|up regulation of tactition, sensory detection of mechanical stimulus|upregulation of perception of touch, sensory detection of mechanical stimulus|up-regulation of sensory detection of mechanical stimulus during perception of touch|up-regulation of detection of mechanical stimulus involved in sensory perception of touch|positive regulation of sensory transduction of mechanical stimulus during perception of touch|up regulation of detection of mechanical stimulus involved in sensory perception of touch|up regulation of perception of touch, detection of mechanical stimulus|positive regulation of tactition, sensory detection of mechanical stimulus|upregulation of perception of touch, sensory transduction of mechanical stimulus|up-regulation of perception of touch, detection of mechanical stimulus|activation of detection of mechanical stimulus involved in sensory perception of touch|up-regulation of perception of touch, sensory detection of mechanical stimulus|up regulation of perception of touch, sensory detection of mechanical stimulus|up-regulation of perception of touch, sensory transduction of mechanical stimulus|positive regulation of perception of touch, sensory detection of mechanical stimulus|upregulation of tactition, sensory detection of mechanical stimulus|upregulation of perception of touch, detection of mechanical stimulus|activation of perception of touch, sensory transduction of mechanical stimulus|positive regulation of perception of touch, detection of mechanical stimulus|upregulation of sensory transduction of mechanical stimulus during perception of touch|activation of sensory detection of mechanical stimulus during perception of touch|up-regulation of sensory transduction of mechanical stimulus during perception of touch|upregulation of sensory detection of mechanical stimulus during perception of touch|positive regulation of sensory detection of mechanical stimulus during perception of touch|activation of perception of touch, sensory detection of mechanical stimulus|activation of tactition, sensory detection of mechanical stimulus|positive regulation of perception of touch, sensory transduction of mechanical stimulus|activation of sensory transduction of mechanical stimulus during perception of touch hbye 2017-01-09T15:11:23Z biological_process owl:Class
GO:0038165 biolink:NamedThing oncostatin-M-mediated signaling pathway A series of molecular signals initiated by the binding of oncostatin-M (OSM) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways. got7fsn_ti oncostatin-M signaling pathway|OSM signaling pathway bf 2012-05-14T02:54:30Z biological_process owl:Class
GO:1990235 biolink:NamedThing diamine N-acetyltransferase complex A protein complex which is capable of diamine N-acetyltransferase activity. got7fsn_ti SAT complex|spermidine acetyltransferase complex|SAT tetramer bhm 2013-11-13T16:29:45Z cellular_component owl:Class
GO:0044222 biolink:NamedThing anammoxosome An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism. got7fsn_ti jl 2009-11-12T04:03:24Z cellular_component owl:Class
GO:0002900 biolink:NamedThing positive regulation of central B cell deletion Any process that activates or increases the frequency, rate, or extent of central B cell deletion. got7fsn_ti up-regulation of central B cell deletion|stimulation of central B cell deletion|activation of central B cell deletion|up regulation of central B cell deletion|upregulation of central B cell deletion biological_process owl:Class
GO:0031357 biolink:NamedThing integral component of chloroplast inner membrane The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to chloroplast inner membrane cellular_component owl:Class
GO:0015244 biolink:NamedThing fluconazole transmembrane transporter activity Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections. got7fsn_ti fluconazole transporter activity molecular_function owl:Class
GO:0015903 biolink:NamedThing fluconazole transport The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections. got7fsn_ti biological_process owl:Class
GO:0120019 biolink:NamedThing phosphatidylcholine transfer activity Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti phosphatidylcholine carrier activity|intermembrane phosphatidylcholine transfer activity https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-17T04:22:47Z molecular_function owl:Class
GO:0031210 biolink:NamedThing phosphatidylcholine binding Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. got7fsn_ti molecular_function owl:Class
GO:0106098 biolink:NamedThing NAGS/NAGK complex A protein complex that acts both as N-acetylglutamate synthase (NAGS) catalysing the production of N-Acetylglutamate from glutamate and acetyl-CoA, and as N-acetylglutamate kinase (NAGK) catalysing the reaction ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate. got7fsn_ti hjd 2018-02-15T00:22:31Z cellular_component owl:Class
GO:0140445 biolink:NamedThing chromosome, telomeric repeat region A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19086 pg 2020-03-27T13:29:16Z cellular_component owl:Class
GO:0051893 biolink:NamedThing regulation of focal adhesion assembly Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. got7fsn_ti regulation of adhesion plaque assembly biological_process owl:Class
GO:0120014 biolink:NamedThing phospholipid transfer activity Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti phospholipid carrier activity|intermembrane phospholipid transfer activity https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-17T03:34:17Z molecular_function owl:Class
GO:2000103 biolink:NamedThing positive regulation of mammary stem cell proliferation Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation. got7fsn_ti dph 2010-09-14T06:10:36Z biological_process owl:Class
GO:0015123 biolink:NamedThing acetate transmembrane transporter activity Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid. got7fsn_ti molecular_function owl:Class
GO:0062073 biolink:NamedThing histone mRNA stem-loop binding complex A protein-containing complex composed of a stem-loop binding protein (in most species SLBP) and its interacting partner (SLIP1 or MIF4GD in most species) that binds to the histone mRNA (hmRNA) 3-prime-stem-loop structure. Facilitates hmRNA translation initiation and may also be involved in its processing and nuclear export. got7fsn_ti SLBP-MIF4GD complex|SLBP-SLIP1 complex dph 2018-09-10T13:46:56Z cellular_component owl:Class
GO:1901239 biolink:NamedThing malonate(1-) transmembrane transporter activity Enables the transfer of malonate(1-) from one side of a membrane to the other. got7fsn_ti malonic acid uptake transmembrane transporter activity al 2012-08-07T15:09:02Z GO:1901549 RHEA:33115 molecular_function owl:Class
GO:1901553 biolink:NamedThing malonic acid transmembrane transport The directed movement of malonic acid across a membrane. got7fsn_ti malonic acid membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. pr 2012-10-30T15:23:54Z biological_process owl:Class
GO:0038021 biolink:NamedThing leptin receptor activity Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti bf 2011-06-27T01:36:45Z molecular_function owl:Class
GO:0000425 biolink:NamedThing pexophagy The selective autophagy process in which a peroxisome is degraded by macroautophagy. got7fsn_ti macropexophagy biological_process owl:Class
GO:0015827 biolink:NamedThing tryptophan transport The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti L-tryptophan transport biological_process owl:Class
GO:0060297 biolink:NamedThing regulation of sarcomere organization Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. got7fsn_ti regulation of sarcomere organisation biological_process owl:Class
GO:0043942 biolink:NamedThing negative regulation of sexual sporulation resulting in formation of a cellular spore Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis. got7fsn_ti biological_process owl:Class
GO:0014018 biolink:NamedThing neuroblast fate specification The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0097052 biolink:NamedThing L-kynurenine metabolic process The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine). got7fsn_ti L-kynurenine metabolism pr 2011-05-24T03:28:44Z biological_process owl:Class
GO:0032117 biolink:NamedThing horsetail-astral microtubule array An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement. got7fsn_ti HAA cellular_component owl:Class
GO:0010610 biolink:NamedThing regulation of mRNA stability involved in response to stress Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance. got7fsn_ti biological_process owl:Class
GO:0120281 biolink:NamedThing autolysosome membrane A lipid bilayer that surrounds an autolysosome, a single-membrane-bounded vesicle in which endogenous cellular material is degraded. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20239 krc 2020-11-17T02:46:19Z cellular_component owl:Class
GO:0060669 biolink:NamedThing embryonic placenta morphogenesis The process in which the embryonic placenta is generated and organized. got7fsn_ti dph 2009-06-02T09:33:37Z biological_process owl:Class
GO:0034507 biolink:NamedThing chromosome, centromeric outer repeat region The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it. got7fsn_ti chromosome, centric outer repeat region cellular_component owl:Class
GO:1903381 biolink:NamedThing regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway. got7fsn_ti regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway|regulation of endoplasmic reticulum stress-induced neuron apoptosis|regulation of neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|regulation of ER stress-induced neuron apoptosis bf 2014-08-27T08:45:29Z biological_process owl:Class
GO:0120110 biolink:NamedThing interphase mitotic telomere clustering The process whereby the mitotic telomeres are gathered together during, or prior to, attachment to the nuclear envelope. got7fsn_ti mitotic telomere clustering during interphase It is likely that both intra chromosome telomere clustering and inter-chromosome occur because a single focus is sometimes observed, although this has yet to be proven. krc 2017-11-01T18:09:08Z biological_process owl:Class
GO:0055021 biolink:NamedThing regulation of cardiac muscle tissue growth Any process that modulates the frequency, rate or extent of cardiac muscle growth. got7fsn_ti biological_process owl:Class
GO:0061932 biolink:NamedThing negative regulation of erythrocyte enucleation Any process that decreases the frequency, rate or extent of erythrocyte enucleation. got7fsn_ti dph 2017-09-05T13:00:15Z biological_process owl:Class
GO:0061178 biolink:NamedThing regulation of insulin secretion involved in cellular response to glucose stimulus Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. got7fsn_ti regulation of insulin secretion in response to glucose dph 2010-07-13T09:38:42Z biological_process owl:Class
GO:0071402 biolink:NamedThing cellular response to lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoprotein particle stimulus. got7fsn_ti mah 2009-12-14T02:48:51Z biological_process owl:Class
GO:0008645 biolink:NamedThing hexose transmembrane transport The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule. got7fsn_ti low-affinity hexose transport|hexose transport|hexose membrane transport|high-affinity hexose transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-08T10:27:23Z GO:0035428|GO:0008647|GO:0008646 biological_process owl:Class
GO:0150200 biolink:NamedThing regulation of transport across blood-brain barrier Any process that modulates the frequency, rate or extent of transport across the blood-brain barrier. got7fsn_ti bc 2020-03-26T19:22:26Z biological_process owl:Class
GO:1900137 biolink:NamedThing negative regulation of chemokine activity Any process that stops, prevents or reduces the frequency, rate or extent of chemokine activity. got7fsn_ti down-regulation of chemokine activity|inhibition of chemokine activity|downregulation of chemokine activity|down regulation of chemokine activity bf 2012-02-28T01:36:33Z biological_process owl:Class
GO:0045700 biolink:NamedThing regulation of spermatid nuclear differentiation Any process that modulates the frequency, rate or extent of spermatid nuclear differentiation. got7fsn_ti biological_process owl:Class
GO:1905881 biolink:NamedThing positive regulation of oogenesis Any process that activates or increases the frequency, rate or extent of oogenesis. got7fsn_ti up regulation of ovum development|positive regulation of ovum development|up-regulation of oogenesis|upregulation of ovum development|up-regulation of ovum development|activation of ovum development|activation of oogenesis|upregulation of oogenesis|up regulation of oogenesis hbye 2017-01-31T09:31:23Z biological_process owl:Class
GO:1903425 biolink:NamedThing fluoride transmembrane transporter activity Enables the transfer of fluoride from one side of a membrane to the other. got7fsn_ti mcc 2014-09-09T21:27:55Z molecular_function owl:Class
GO:1903424 biolink:NamedThing fluoride transmembrane transport The process in which fluoride is transported across a membrane. got7fsn_ti transmembrane fluoride transport|fluoride membrane transport mcc 2014-09-09T21:21:01Z biological_process owl:Class
GO:0033157 biolink:NamedThing regulation of intracellular protein transport Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells. got7fsn_ti biological_process owl:Class
GO:0045167 biolink:NamedThing asymmetric protein localization involved in cell fate determination Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types. got7fsn_ti asymmetric protein localization involved in cell fate commitment|asymmetric protein localization resulting in cell fate commitment|cell fate commitment, asymmetric protein localization|asymmetric protein localisation involved in cell fate determination biological_process owl:Class
GO:1904158 biolink:NamedThing axonemal central apparatus assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal central apparatus. got7fsn_ti axonemal central apparatus formation krc 2015-04-16T18:46:11Z biological_process owl:Class
GO:0016318 biolink:NamedThing ommatidial rotation The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification. got7fsn_ti biological_process owl:Class
GO:0035452 biolink:NamedThing extrinsic component of plastid membrane The component of a plastid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti peripheral to plastid membrane|extrinsic to plastid membrane bf 2010-04-16T10:19:33Z cellular_component owl:Class
GO:1905410 biolink:NamedThing regulation of mitotic cohesin unloading Any process that modulates the frequency, rate or extent of mitotic cohesin unloading. got7fsn_ti vw 2016-08-25T15:45:22Z biological_process owl:Class
GO:0071657 biolink:NamedThing positive regulation of granulocyte colony-stimulating factor production Any process that activates or increases the frequency, rate, or extent of production of granulocyte colony-stimulating factor. got7fsn_ti positive regulation of lenograstim production|positive regulation of colony stimulating factor 3 (granulocyte) production|positive regulation of CSF3 production|positive regulation of G-CSF production|positive regulation of pluripoietin production|positive regulation of granulocyte colony stimulating factor production|positive regulation of filgrastim production mah 2010-02-12T10:41:14Z biological_process owl:Class
GO:1904838 biolink:NamedThing regulation of male germ-line stem cell asymmetric division Any process that modulates the frequency, rate or extent of male germ-line stem cell asymmetric division. got7fsn_ti regulation of male germ-line stem cell renewal sl 2015-12-05T00:28:31Z biological_process owl:Class
GO:0003098 biolink:NamedThing tubuloglomerular feedback The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus. got7fsn_ti Wikipedia:Tubuloglomerular_feedback biological_process owl:Class
GO:0002788 biolink:NamedThing regulation of antifungal peptide production Any process that modulates the frequency, rate, or extent of antifungal peptide production. got7fsn_ti biological_process owl:Class
GO:0120016 biolink:NamedThing sphingolipid transfer activity Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti sphingolipid carrier activity|intermembrane sphingolipid transfer activity https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-17T03:52:30Z molecular_function owl:Class
GO:0046625 biolink:NamedThing sphingolipid binding Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). got7fsn_ti molecular_function owl:Class
GO:0140241 biolink:NamedThing translation at synapse Translation that occurs at the synapse. got7fsn_ti https://github.com/geneontology/synapse/issues/210 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T09:23:12Z biological_process owl:Class
GO:1901191 biolink:NamedThing negative regulation of formation of translation initiation ternary complex Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex. got7fsn_ti down-regulation of formation of translation initiation ternary complex|inhibition of translation initiation ternary complex assembly|inhibition of formation of translation initiation ternary complex|downregulation of formation of translation initiation ternary complex|downregulation of translation initiation ternary complex assembly|down-regulation of translation initiation ternary complex assembly|down regulation of formation of translation initiation ternary complex|down regulation of translation initiation ternary complex assembly|negative regulation of translation initiation ternary complex assembly ss 2012-07-25T02:27:21Z biological_process owl:Class
GO:0071383 biolink:NamedThing cellular response to steroid hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus. got7fsn_ti mah 2009-12-11T03:49:02Z biological_process owl:Class
GO:2000432 biolink:NamedThing negative regulation of cytokinesis, actomyosin contractile ring assembly Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. got7fsn_ti negative regulation of contractile ring assembly vw 2011-03-03T12:18:16Z biological_process owl:Class
GO:1900242 biolink:NamedThing regulation of synaptic vesicle endocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis. got7fsn_ti regulation of synaptic vesicle retrieval rl 2012-03-28T01:40:26Z biological_process owl:Class
GO:1902736 biolink:NamedThing positive regulation of receptor-mediated virion attachment to host cell Any process that activates or increases the frequency, rate or extent of receptor-mediated virion attachment to host cell. got7fsn_ti up-regulation of virion attachment, binding of host cell surface receptor|activation of receptor-mediated virion attachment to host cell|upregulation of receptor-mediated virion attachment to host cell|positive regulation of virion attachment, binding of host cell surface receptor|up regulation of receptor-mediated virion attachment to host cell|up regulation of virion attachment, binding of host cell surface receptor|up-regulation of receptor-mediated virion attachment to host cell|activation of virion attachment, binding of host cell surface receptor|upregulation of virion attachment, binding of host cell surface receptor als 2014-02-25T12:26:16Z biological_process owl:Class
GO:0017109 biolink:NamedThing glutamate-cysteine ligase complex An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine. got7fsn_ti gamma-glutamylcysteine synthetase complex cellular_component owl:Class
CHEBI:350546 biolink:NamedThing got7fsn_ti owl:Class
GO:0097104 biolink:NamedThing postsynaptic membrane assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). got7fsn_ti post-synaptic membrane assembly pr 2011-07-27T01:26:49Z biological_process owl:Class
GO:0061889 biolink:NamedThing negative regulation of astrocyte activation Any process that decreases the frequency, rate or extent of astrocyte activation. got7fsn_ti dph 2017-06-01T22:29:43Z biological_process owl:Class
GO:0000229 biolink:NamedThing cytoplasmic chromosome A chromosome found in the cytoplasm. got7fsn_ti cytoplasmic interphase chromosome cellular_component owl:Class
GO:1903437 biolink:NamedThing negative regulation of mitotic cytokinetic process Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinetic process. got7fsn_ti inhibition of mitotic cytokinetic process|down-regulation of mitotic cytokinetic process|down regulation of mitotic cytokinetic process|downregulation of mitotic cytokinetic process tb 2014-09-15T23:11:47Z biological_process owl:Class
GO:0102025 biolink:NamedThing ABC-type thiosulfate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in). got7fsn_ti thiosulfate transmembrane-transporting ATPase activity|thiosulphate ABC transporter activity|ATPase-coupled thiosulfate transmembrane transporter activity https://github.com/geneontology/go-ontology/issues/14642 GO:0032146 RHEA:29871|MetaCyc:ABC-7-RXN|EC:7.3.2.3 molecular_function owl:Class
GO:0015709 biolink:NamedThing thiosulfate transport The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti thiosulphate transport biological_process owl:Class
GO:0062248 biolink:NamedThing cleistothecium formation The process of producing a cleistothecium, a closed sexual fruiting body that contains ascospores in linear asci. Cleistothecia are present in some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella. got7fsn_ti dph 2020-05-08T16:14:06Z biological_process owl:Class
GO:1904875 biolink:NamedThing regulation of DNA ligase activity Any process that modulates the frequency, rate or extent of DNA ligase activity. got7fsn_ti rl 2015-12-18T18:35:30Z biological_process owl:Class
GO:0015416 biolink:NamedThing ABC-type phosphonate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). got7fsn_ti phosphonate ABC transporter|ATPase-coupled alkylphosphonate transmembrane transporter activity|alkylphosphonate transmembrane-transporting ATPase activity|alkylphosphonate ABC transporter activity|organic phosphonate transmembrane-transporting ATPase activity|ATP phosphohydrolase (phosphonate-transporting)|phosphonate-transporting ATPase activity|ATPase-coupled organic phosphonate transmembrane transporter activity|organic phosphonate transmembrane transporter activity|alkylphosphonate transmembrane transporter activity|phosphonate transporting ATPase activity GO:0102017|GO:0042917|GO:0015604 RHEA:18065|MetaCyc:3.6.3.28-RXN|EC:7.3.2.2|MetaCyc:ABC-23-RXN molecular_function owl:Class
GO:0015716 biolink:NamedThing organic phosphonate transport The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). got7fsn_ti alkylphosphonate transport https://github.com/geneontology/go-ontology/issues/17164 GO:0042916 biological_process owl:Class
GO:1904876 biolink:NamedThing negative regulation of DNA ligase activity Any process that stops, prevents or reduces the frequency, rate or extent of DNA ligase activity. got7fsn_ti downregulation of DNA ligase activity|inhibition of DNA ligase activity|down regulation of DNA ligase activity|down-regulation of DNA ligase activity rl 2015-12-18T18:35:37Z biological_process owl:Class
GO:2001110 biolink:NamedThing negative regulation of lens epithelial cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of lens epithelial cell proliferation. got7fsn_ti yaf 2011-09-30T02:04:57Z biological_process owl:Class
GO:0021599 biolink:NamedThing abducens nerve formation The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye. got7fsn_ti CN VI biosynthesis|CN VI formation biological_process owl:Class
GO:0120234 biolink:NamedThing stereocilium coat A glycocalyx on the the endolymphatic surface of a cochlear hair cell that coats the external surface of each stereocilium and maintains a small distance between adjacent stereocilia in the bundle. got7fsn_ti stereocilium glycocalyx|auditory hair cell glycocalyx https://github.com/geneontology/go-ontology/issues/19782 krc 2020-07-15T00:56:35Z cellular_component owl:Class
GO:0015547 biolink:NamedThing nalidixic acid transmembrane transporter activity Enables the transfer of nalidixic acid from one side of a membrane to the other. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication. got7fsn_ti nalidixic acid transporter activity|carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity molecular_function owl:Class
GO:0015896 biolink:NamedThing nalidixic acid transport The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication. got7fsn_ti biological_process owl:Class
GO:0072192 biolink:NamedThing ureter epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter. got7fsn_ti mah 2010-03-01T01:53:17Z biological_process owl:Class
GO:0001928 biolink:NamedThing regulation of exocyst assembly Any process that modulates the frequency, rate or extent of exocyst assembly. got7fsn_ti Note that the assembly is regulated by several small GTPases of the Rab and Rho families. biological_process owl:Class
GO:0016595 biolink:NamedThing glutamate binding Binding to glutamate, the anion of 2-aminopentanedioic acid. got7fsn_ti glutamic acid binding molecular_function owl:Class
GO:0044201 biolink:NamedThing host cell nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope. got7fsn_ti jl 2009-10-21T11:08:33Z cellular_component owl:Class
GO:0009324 biolink:NamedThing D-amino-acid dehydrogenase complex A protein complex that possesses D-amino-acid dehydrogenase activity. got7fsn_ti See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'. cellular_component owl:Class
GO:0016014 biolink:NamedThing dystrobrevin complex A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex. got7fsn_ti cellular_component owl:Class
GO:0000041 biolink:NamedThing transition metal ion transport The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. got7fsn_ti transition metal transport biological_process owl:Class
GO:1902755 biolink:NamedThing sulfurated eukaryotic molybdenum cofactor(2-) metabolic process The chemical reactions and pathways involving sulfurated eukaryotic molybdenum cofactor(2-). got7fsn_ti sulfurated eukaryotic molybdenum cofactor(2-) metabolism dph 2014-03-05T23:29:13Z biological_process owl:Class
GO:0005697 biolink:NamedThing telomerase holoenzyme complex Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits. got7fsn_ti cellular_component owl:Class
CHEBI:24834 biolink:NamedThing got7fsn_ti owl:Class
GO:0008258 biolink:NamedThing head involution Movement of the anterior ectoderm to the interior of the embryo. got7fsn_ti biological_process owl:Class
GO:0030015 biolink:NamedThing CCR4-NOT core complex The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. got7fsn_ti cellular_component owl:Class
GO:0005310 biolink:NamedThing dicarboxylic acid transmembrane transporter activity Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. got7fsn_ti dicarboxylate carrier|sodium:dicarboxylate/tricarboxylate symporter activity|dicarboxylic acid permease activity|dicarboxylate (succinate/fumarate/malate) antiporter activity GO:0005312|GO:0015365 Reactome:R-HSA-1614546|Reactome:R-HSA-372843 molecular_function owl:Class
GO:0006835 biolink:NamedThing dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti sodium:dicarboxylate transport GO:0006841 biological_process owl:Class
GO:0106021 biolink:NamedThing negative regulation of vesicle docking Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle docking. got7fsn_ti negative regulation of vesicle to membrane docking hjd 2017-05-16T14:05:29Z biological_process owl:Class
GO:0035027 biolink:NamedThing leading edge cell fate commitment The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet. got7fsn_ti biological_process owl:Class
GO:1903543 biolink:NamedThing positive regulation of exosomal secretion Any process that activates or increases the frequency, rate or extent of exosomal secretion. got7fsn_ti up regulation of secretion of exosome|up regulation of exosomal protein secretion|up-regulation of secretion of exosome|up-regulation of exosomal secretion|activation of exosomal secretory pathway|activation of extracellular vesicular exosome secretion|up-regulation of extracellular vesicular exosome secretion|positive regulation of extracellular vesicular exosome secretion|activation of exosomal secretion|up-regulation of exosomal protein secretion|up regulation of extracellular vesicular exosome secretion|upregulation of exosomal protein secretion|upregulation of exosomal secretion|up regulation of exosomal secretory pathway|positive regulation of secretion of exosome|activation of exosomal protein secretion|positive regulation of exosomal secretory pathway|positive regulation of exosomal protein secretion|upregulation of secretion of exosome|upregulation of exosomal secretory pathway|up regulation of exosomal secretion|activation of secretion of exosome|upregulation of extracellular vesicular exosome secretion|up-regulation of exosomal secretory pathway pga 2014-10-14T11:39:10Z biological_process owl:Class
GO:0106024 biolink:NamedThing negative regulation of pupariation Any process that stops, prevents or reduces the rate of onset of pupariation. got7fsn_ti hjd 2017-05-24T19:35:29Z biological_process owl:Class
CL:0000023 biolink:NamedThing got7fsn_ti owl:Class
GO:0045009 biolink:NamedThing chitosome An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum. got7fsn_ti cellular_component owl:Class
GO:0031151 biolink:NamedThing histone methyltransferase activity (H3-K79 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein. got7fsn_ti histone lysine N-methyltransferase activity (H3-K79 specific)|histone methylase activity (H3-K79 specific) molecular_function owl:Class
CL:0002369 biolink:NamedThing got7fsn_ti owl:Class
GO:1903097 biolink:NamedThing regulation of CENP-A containing nucleosome assembly Any process that modulates the rate, frequency or extent of the formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres. got7fsn_ti regulation of centromere-specific nucleosome assembly|regulation of CENP-A loading|regulation of centromere-specific histone exchange|regulation of DNA replication-independent nucleosome assembly at centromere|regulation of centromere specific nucleosome exchange|regulation of CenH3-containing nucleosome assembly at centromere|regulation of CENP-A deposition|regulation of centromeric DNA replication-independent nucleosome assembly vw 2014-06-03T16:15:30Z biological_process owl:Class
GO:2000470 biolink:NamedThing positive regulation of peroxidase activity Any process that activates or increases the frequency, rate or extent of peroxidase activity. got7fsn_ti positive regulation of peroxidase reaction|positive regulation of oxyperoxidase activity|positive regulation of donor:hydrogen-peroxide oxidoreductase activity bf 2011-03-08T02:19:25Z biological_process owl:Class
GO:0060339 biolink:NamedThing negative regulation of type I interferon-mediated signaling pathway Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. got7fsn_ti negative regulation of type I interferon-mediated signalling pathway biological_process owl:Class
GO:1902121 biolink:NamedThing lithocholic acid binding Binding to lithocholic acid. got7fsn_ti LCA binding bf 2013-05-15T16:05:12Z molecular_function owl:Class
CL:0001031 biolink:NamedThing got7fsn_ti owl:Class
GO:0000327 biolink:NamedThing lytic vacuole within protein storage vacuole A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole. got7fsn_ti cellular_component owl:Class
GO:1903432 biolink:NamedThing regulation of TORC1 signaling Any process that modulates the frequency, rate or extent of TORC1 signaling. got7fsn_ti regulation of TORC1 signal transduction jl 2014-09-15T13:35:39Z biological_process owl:Class
GO:0030208 biolink:NamedThing dermatan sulfate biosynthetic process The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. got7fsn_ti dermatan sulfate anabolism|dermatan sulfate formation|dermatan sulphate biosynthesis|chondroitin sulfate B biosynthesis|dermatan sulfate biosynthesis|dermatan sulfate synthesis|dermatan sulphate biosynthetic process|chondroitin sulfate B biosynthetic process biological_process owl:Class
GO:0050651 biolink:NamedThing dermatan sulfate proteoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. got7fsn_ti dermatan sulfate proteoglycan synthesis|chondroitin sulfate B proteoglycan biosynthetic process|dermatan sulfate proteoglycan anabolism|dermatan sulphate proteoglycan biosynthesis|dermatan sulfate proteoglycan formation|dermatan sulfate proteoglycan biosynthesis|dermatan sulphate proteoglycan biosynthetic process|chondroitin sulfate B proteoglycan biosynthesis biological_process owl:Class
GO:0010705 biolink:NamedThing meiotic DNA double-strand break processing involved in reciprocal meiotic recombination The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate. got7fsn_ti biological_process owl:Class
GO:1904848 biolink:NamedThing negative regulation of cell chemotaxis to fibroblast growth factor Any process that stops, prevents or reduces the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. got7fsn_ti downregulation of cell chemotaxis to fibroblast growth factor|inhibition of cell chemotaxis to fibroblast growth factor|down regulation of cell chemotaxis to fibroblast growth factor|down-regulation of cell chemotaxis to fibroblast growth factor rph 2015-12-10T12:04:08Z biological_process owl:Class
GO:0004861 biolink:NamedThing cyclin-dependent protein serine/threonine kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. got7fsn_ti cyclin dependent kinase inhibitor|cyclin dependent protein kinase inhibitor activity|cyclin-dependent kinase inhibitor|CDK inhibitor|cyclin-dependent protein kinase inhibitor activity Reactome:R-HSA-69562|Reactome:R-HSA-187934 molecular_function owl:Class
GO:0034223 biolink:NamedThing regulation of ascospore wall chitin biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ascospore wall chitin. got7fsn_ti regulation of ascospore wall chitin biosynthesis|regulation of ascospore wall chitin formation|regulation of ascospore wall chitin synthesis|regulation of ascospore wall chitin anabolism biological_process owl:Class
GO:0070237 biolink:NamedThing positive regulation of activation-induced cell death of T cells Any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells. got7fsn_ti up-regulation of activation-induced cell death of T cells|positive regulation of activation-induced cell death of T-lymphocytes|up regulation of activation-induced cell death of T cells|positive regulation of AICD|activation of activation-induced cell death of T cells|positive regulation of activated T cell apoptosis|stimulation of activation-induced cell death of T cells|upregulation of activation-induced cell death of T cells|positive regulation of activation-induced cell death of T lymphocytes|positive regulation of antigen-driven apoptosis|positive regulation of activation-induced cell death of T-cells biological_process owl:Class
CL:0008019 biolink:NamedThing got7fsn_ti owl:Class
GO:1905700 biolink:NamedThing negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of xenobiotic transmembrane export. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti negative regulation of xenobiotic transmembrane export|downregulation of drug transmembrane export|down-regulation of drug transmembrane export|down regulation of drug transmembrane export|negative regulation of drug transmembrane export|inhibition of drug transmembrane export https://github.com/geneontology/go-ontology/issues/19460|https://github.com/geneontology/go-ontology/issues/17083 sl 2016-11-15T16:46:36Z biological_process owl:Class
CHEBI:33708 biolink:NamedThing got7fsn_ti owl:Class
GO:0030910 biolink:NamedThing olfactory placode formation The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity. got7fsn_ti biological_process owl:Class
GO:1901389 biolink:NamedThing negative regulation of transforming growth factor beta activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation. got7fsn_ti downregulation of transforming growth factor beta activation|down-regulation of TGFbeta activation|inhibition of TGFbeta activation|down-regulation of TGF-beta activation|down-regulation of transforming growth factor beta activation|negative regulation of TGF-B activation|downregulation of TGFbeta activation|inhibition of TGFB activation|downregulation of TGF-B activation|negative regulation of TGFB activation|downregulation of TGFB activation|down regulation of TGFbeta activation|down-regulation of latent TGF-beta activation|down regulation of TGFB activation|inhibition of transforming growth factor beta activation|negative regulation of latent TGF-beta activation|downregulation of TGF-beta activation|inhibition of TGF-B activation|down-regulation of TGF-B activation|down regulation of latent TGF-beta activation|downregulation of latent TGF-beta activation|inhibition of latent TGF-beta activation|negative regulation of TGF-beta activation|down regulation of transforming growth factor beta activation|downregulation of L-TGF-beta activation|down-regulation of TGFB activation|down regulation of TGF-B activation|inhibition of L-TGF-beta activation|negative regulation of TGFbeta activation|down regulation of L-TGF-beta activation|inhibition of TGF-beta activation|down-regulation of L-TGF-beta activation|down regulation of TGF-beta activation|negative regulation of L-TGF-beta activation bf 2012-10-01T10:33:09Z biological_process owl:Class
GO:0060702 biolink:NamedThing negative regulation of endoribonuclease activity Any process that decreases the rate, frequency or extent of the catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. got7fsn_ti dph 2009-06-08T02:52:27Z biological_process owl:Class
GO:1903637 biolink:NamedThing negative regulation of protein insertion into mitochondrial outer membrane Any process that stops, prevents or reduces the frequency, rate or extent of protein insertion into mitochondrial outer membrane. got7fsn_ti down-regulation of protein transport into mitochondrial outer membrane|down-regulation of mitochondrial outer membrane protein import|down-regulation of protein insertion into mitochondrial outer membrane|downregulation of protein insertion into mitochondrial outer membrane|negative regulation of protein transport into mitochondrial outer membrane|inhibition of mitochondrial outer membrane protein import|downregulation of mitochondrial outer membrane protein import|down regulation of protein insertion into mitochondrial outer membrane|inhibition of protein import into mitochondrial outer membrane|downregulation of protein import into mitochondrial outer membrane|down regulation of protein transport into mitochondrial outer membrane|negative regulation of mitochondrial outer membrane protein import|down-regulation of protein import into mitochondrial outer membrane|down regulation of protein import into mitochondrial outer membrane|inhibition of protein insertion into mitochondrial outer membrane|negative regulation of protein import into mitochondrial outer membrane|down regulation of mitochondrial outer membrane protein import|downregulation of protein transport into mitochondrial outer membrane|inhibition of protein transport into mitochondrial outer membrane pga 2014-11-20T15:54:53Z biological_process owl:Class
GO:2000729 biolink:NamedThing positive regulation of mesenchymal cell proliferation involved in ureter development Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in ureter development. got7fsn_ti positive regulation of ureter mesenchymal cell proliferation|positive regulation of ureteral mesenchymal cell proliferation yaf 2011-06-10T02:27:19Z biological_process owl:Class
PO:0009073 biolink:NamedThing got7fsn_ti owl:Class
GO:1903007 biolink:NamedThing positive regulation of Lys63-specific deubiquitinase activity Any process that activates or increases the frequency, rate or extent of Lys63-specific deubiquitinase activity. got7fsn_ti up regulation of Lys63-specific deubiquitinase activity|upregulation of Lys63-specific deubiquitinase activity|up-regulation of Lys63-specific deubiquitinase activity|activation of Lys63-specific deubiquitinase activity bf 2014-05-12T15:47:35Z biological_process owl:Class
GO:0033162 biolink:NamedThing melanosome membrane The lipid bilayer surrounding a melanosome. got7fsn_ti cellular_component owl:Class
GO:0120125 biolink:NamedThing PNGase complex A protein complex responsible for the catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue. got7fsn_ti krc 2018-02-12T16:31:57Z cellular_component owl:Class
GO:0035977 biolink:NamedThing protein deglycosylation involved in glycoprotein catabolic process The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein. got7fsn_ti bf 2011-08-18T10:31:23Z biological_process owl:Class
GO:0010329 biolink:NamedThing auxin efflux transmembrane transporter activity Enables the transfer of auxin, from one side of a membrane to the other, out of a cell. got7fsn_ti auxin efflux facilitator|auxin efflux carrier molecular_function owl:Class
GO:1904174 biolink:NamedThing negative regulation of histone demethylase activity (H3-K4 specific) Any process that stops, prevents or reduces the frequency, rate or extent of histone demethylase activity (H3-K4 specific). got7fsn_ti down regulation of histone demethylase activity (H3-K4 specific)|downregulation of histone demethylase activity (H3-K4 specific)|inhibition of histone demethylase activity (H3-K4 specific)|down-regulation of histone demethylase activity (H3-K4 specific) dph 2015-04-24T19:29:38Z biological_process owl:Class
GO:0045688 biolink:NamedThing regulation of antipodal cell differentiation Any process that modulates the frequency, rate or extent of antipodal cell differentiation. got7fsn_ti biological_process owl:Class
GO:0033618 biolink:NamedThing plasma membrane respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase) in the plasma membrane. got7fsn_ti plasma membrane cytochrome c oxidase biogenesis|plasma membrane cytochrome c oxidase complex assembly biological_process owl:Class
GO:1903206 biolink:NamedThing negative regulation of hydrogen peroxide-induced cell death Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death. got7fsn_ti down regulation of cell death in response to H2O2|inhibition of cell death in response to H2O2|negative regulation of hydrogen peroxide-mediated cell death|negative regulation of cell death in response to hydrogen peroxide|inhibition of hydrogen peroxide-mediated cell death|down-regulation of hydrogen peroxide-mediated cell death|protection against hydrogen peroxide-induced cell death|downregulation of cell death in response to H2O2|down regulation of hydrogen peroxide-mediated cell death|inhibition of cell death in response to hydrogen peroxide|down regulation of cell death in response to hydrogen peroxide|downregulation of cell death in response to hydrogen peroxide|downregulation of hydrogen peroxide-mediated cell death|negative regulation of cell death in response to H2O2|protection against H2O2-induced cell death|down-regulation of cell death in response to hydrogen peroxide|down-regulation of cell death in response to H2O2 bf 2014-07-21T16:21:53Z biological_process owl:Class
GO:1901045 biolink:NamedThing negative regulation of oviposition Any process that stops, prevents or reduces the frequency, rate or extent of oviposition. got7fsn_ti downregulation of oviposition|negative regulation of egg laying|down regulation of egg-laying|negative regulation of egg-laying|down-regulation of egg laying|down-regulation of egg-laying|down-regulation of oviposition|downregulation of egg laying|inhibition of egg laying|down regulation of egg laying|downregulation of egg-laying|down regulation of oviposition|inhibition of egg-laying|inhibition of oviposition kmv 2012-06-27T06:19:58Z biological_process owl:Class
GO:0051759 biolink:NamedThing sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation The directed movement of sister chromosomes from the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during meiosis II. got7fsn_ti sister chromosome movement towards spindle pole during meiosis II|meiosis II, sister chromosome movement towards spindle pole biological_process owl:Class
GO:0098640 biolink:NamedThing integrin binding involved in cell-matrix adhesion Any integrin binding that occurs as part of the process of cell-matrix adhesion. got7fsn_ti molecular_function owl:Class
GO:0008191 biolink:NamedThing metalloendopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. got7fsn_ti metalloproteinase inhibitor|metalloprotease inhibitor molecular_function owl:Class
CHEBI:15986 biolink:NamedThing got7fsn_ti owl:Class
GO:2000202 biolink:NamedThing positive regulation of ribosomal subunit export from nucleus Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus. got7fsn_ti positive regulation of ribosomal subunit-nucleus export|positive regulation of ribosomal subunit export from cell nucleus|positive regulation of ribosomal subunit export out of nucleus|positive regulation of ribosomal subunit transport from nucleus to cytoplasm|positive regulation of ribosome export from nucleus mah 2010-10-26T10:44:36Z biological_process owl:Class
GO:0001960 biolink:NamedThing negative regulation of cytokine-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway. got7fsn_ti down-regulation of cytokine mediated signaling pathway|downregulation of cytokine mediated signaling pathway|inhibition of cytokine mediated signaling pathway|down regulation of cytokine mediated signaling pathway|negative regulation of cytokine mediated signalling pathway|negative regulation of cytokine mediated signaling pathway|negative regulation of cytokine and chemokine mediated signaling pathway biological_process owl:Class
GO:0031315 biolink:NamedThing extrinsic component of mitochondrial outer membrane The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti extrinsic to mitochondrial outer membrane cellular_component owl:Class
GO:0030178 biolink:NamedThing negative regulation of Wnt signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway. got7fsn_ti down-regulation of frizzled signaling pathway|inhibition of Wnt receptor signaling pathway|inhibition of frizzled signaling pathway|down-regulation of Wnt receptor signaling pathway|down regulation of Wnt receptor signaling pathway|negative regulation of frizzled signaling pathway|downregulation of Wnt receptor signaling pathway|negative regulation of frizzled signalling pathway|negative regulation of Wnt receptor signaling pathway|downregulation of frizzled signaling pathway|negative regulation of Wnt receptor signalling pathway|down regulation of frizzled signaling pathway|negative regulation of Wnt-activated signaling pathway GO:0045810 biological_process owl:Class
GO:0072253 biolink:NamedThing metanephric juxtaglomerulus cell fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric juxtaglomerulus cell. got7fsn_ti mah 2010-03-19T03:55:47Z biological_process owl:Class
GO:0045692 biolink:NamedThing negative regulation of embryo sac central cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of embryo sac central cell differentiation. got7fsn_ti down-regulation of female gametophyte central cell differentiation|negative regulation of female gametophyte central cell differentiation|inhibition of female gametophyte central cell differentiation|down regulation of female gametophyte central cell differentiation|downregulation of female gametophyte central cell differentiation biological_process owl:Class
GO:0015152 biolink:NamedThing glucose-6-phosphate transmembrane transporter activity Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. got7fsn_ti molecular_function owl:Class
GO:0015760 biolink:NamedThing glucose-6-phosphate transport The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6. got7fsn_ti biological_process owl:Class
GO:0086087 biolink:NamedThing voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti dph 2011-11-22T01:30:20Z molecular_function owl:Class
GO:0086050 biolink:NamedThing membrane repolarization during bundle of His cell action potential The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. got7fsn_ti membrane repolarization during bundle of His cardiac muscle cell action potential dph 2011-11-16T11:50:41Z biological_process owl:Class
GO:0048012 biolink:NamedThing hepatocyte growth factor receptor signaling pathway The series of molecular signals generated as a consequence of the hepatocyte growth factor receptor binding to one of its physiological ligands. got7fsn_ti HGF receptor signaling pathway|HGF receptor signalling pathway|Met signaling pathway biological_process owl:Class
GO:1904255 biolink:NamedThing negative regulation of iron ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of an iron transmembrane transporter activity. got7fsn_ti down regulation of iron cation channel activity|down-regulation of iron cation channel activity|negative regulation of iron-specific channel activity|downregulation of iron cation channel activity|inhibition of iron cation channel activity|negative regulation of iron channel activity|down regulation of iron-specific channel activity|negative regulation of iron cation channel activity|inhibition of iron channel activity|down regulation of iron channel activity|down-regulation of iron channel activity|downregulation of iron channel activity|downregulation of iron-specific channel activity|inhibition of iron-specific channel activity|down-regulation of iron-specific channel activity kom 2015-05-20T14:05:06Z biological_process owl:Class
GO:1904602 biolink:NamedThing serotonin-activated cation-selective channel complex A protein complex which is capable of serotonin-activated cation-selective channel activity. Mainly found in pre- and postsynaptic membranes of the brain and gastrointestinal tract. Depending on its location it transports Ca2+, Mg2+, Na+ or K+. It is always a pentamer, containing at least the 5HT3A subunit forming 5HT3A homopentamers or 5HT3A/B heteropentamers. In human, 5HT3A/C, A/D and A/E heteropentamers also exist. got7fsn_ti 5-HT3 receptor complex|serotonin receptor complex|5-hydroxytryptamine receptor 3 complex|5-HT-3 receptor complex|5HT3 receptor complex https://github.com/geneontology/go-ontology/issues/12942 An example of this is HTR3A in human (P46098) in PMID:16116092 (inferred from direct assay). bhm 2015-08-26T13:19:49Z cellular_component owl:Class
GO:2000732 biolink:NamedThing positive regulation of termination of RNA polymerase I transcription Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase I transcription. got7fsn_ti positive regulation of transcription termination from RNA polymerase I promoter|positive regulation of transcription termination from Pol I promoter|positive regulation of RNA polymerase I transcription termination dph 2011-06-10T08:43:48Z biological_process owl:Class
GO:0006761 biolink:NamedThing dihydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate. got7fsn_ti 7,8-dihydrofolate biosynthesis|dihydrofolate biosynthesis|7,8-dihydrofolate biosynthetic process|dihydrofolate formation|dihydrofolate anabolism|dihydrofolate synthesis biological_process owl:Class
GO:0042879 biolink:NamedThing aldonate transmembrane transporter activity Enables the transfer of aldonate from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042873 biolink:NamedThing aldonate transmembrane transport The process in which aldonate is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti aldonate transport biological_process owl:Class
GO:0031246 biolink:NamedThing intrinsic component of periplasmic side of cell outer membrane The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor. got7fsn_ti intrinsic to external side of cell outer membrane|intrinsic to internal side of outer membrane|intrinsic to internal side of cell outer membrane|intrinsic to internal leaflet of cell outer membrane cellular_component owl:Class
GO:1901375 biolink:NamedThing acetate ester transmembrane transporter activity Enables the transfer of an acetate ester from one side of a membrane to the other. got7fsn_ti bf 2012-09-28T10:47:08Z molecular_function owl:Class
GO:1901374 biolink:NamedThing acetate ester transport The directed movement of an acetate ester into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti bf 2012-09-28T10:42:13Z biological_process owl:Class
GO:0000936 biolink:NamedThing primary cell septum A cell septum that forms following nuclear division. got7fsn_ti primary septum cellular_component owl:Class
GO:0110111 biolink:NamedThing negative regulation of animal organ morphogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis. got7fsn_ti kmv 2018-07-05T14:25:21Z biological_process owl:Class
GO:0048013 biolink:NamedThing ephrin receptor signaling pathway The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin. got7fsn_ti Eph receptor signalling pathway|Eph receptor signaling pathway biological_process owl:Class
GO:0090406 biolink:NamedThing pollen tube A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain. got7fsn_ti Carries the male gametes to into or near the ovule. May be branched in gymnosperms. This term replaces the obsolete term PO:0006345. Part of pollen tube cell (PO:0025195). tb 2011-01-10T01:59:40Z cellular_component owl:Class
GO:1902796 biolink:NamedThing regulation of snoRNA processing Any process that modulates the frequency, rate or extent of snoRNA processing. got7fsn_ti mah 2014-03-24T12:47:02Z biological_process owl:Class
GO:0072005 biolink:NamedThing maintenance of kidney identity The process in which the identity of a kidney is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti maintenance of kidney anlage identity mah 2010-01-25T11:57:41Z biological_process owl:Class
GO:0015160 biolink:NamedThing beta-glucan transmembrane transporter activity Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds. got7fsn_ti molecular_function owl:Class
GO:1903826 biolink:NamedThing arginine transmembrane transport The directed movement of arginine across a membrane. got7fsn_ti vw 2015-01-20T10:38:15Z biological_process owl:Class
GO:1905451 biolink:NamedThing positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Any process that activates or increases the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis. got7fsn_ti up regulation of Fcgamma receptor-mediated phagocytosis|upregulation of Fcgamma receptor-mediated phagocytosis|activation of Fcgamma receptor-mediated phagocytosis|up-regulation of Fcgamma receptor-mediated phagocytosis|activation of IgG-mediated phagocytosis|positive regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|up regulation of Fc gamma receptor-dependent phagocytosis|up regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of IgG-mediated phagocytosis|upregulation of Fc-gamma receptor signalling pathway involved in phagocytosis|up-regulation of Fc gamma receptor-dependent phagocytosis|up regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|activation of Fc-gamma receptor signalling pathway involved in phagocytosis|up-regulation of IgG-mediated phagocytosis|upregulation of Fc gamma receptor-dependent phagocytosis|up regulation of IgG-mediated phagocytosis|positive regulation of Fcgamma receptor-mediated phagocytosis|activation of Fc-gamma receptor signaling pathway involved in phagocytosis|up-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of Fc gamma receptor-dependent phagocytosis|upregulation of Fc-gamma receptor signaling pathway involved in phagocytosis|upregulation of IgG-mediated phagocytosis|up-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|activation of Fc gamma receptor-dependent phagocytosis sl 2016-09-15T19:42:06Z biological_process owl:Class
GO:0051978 biolink:NamedThing lysophospholipid:sodium symporter activity Enables the directed movement of lysophospholipids from one side of a membrane to the other. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids. got7fsn_ti lysophospholipid transporter activity https://github.com/geneontology/go-ontology/issues/17207 molecular_function owl:Class
GO:0051977 biolink:NamedThing lysophospholipid transport The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lysophospholipid is a phospholipid that lacks one of its fatty acyl chains; it is an intermediate formed during digestion of dietary and biliary phospholipids. got7fsn_ti biological_process owl:Class
GO:1903710 biolink:NamedThing spermine transmembrane transport The process in which spermine is transported across a membrane. got7fsn_ti vw 2014-12-06T08:11:32Z biological_process owl:Class
GO:0014835 biolink:NamedThing myoblast differentiation involved in skeletal muscle regeneration The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:1905880 biolink:NamedThing negative regulation of oogenesis Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis. got7fsn_ti down-regulation of oogenesis|downregulation of oogenesis|down-regulation of ovum development|inhibition of oogenesis|inhibition of ovum development|down regulation of ovum development|negative regulation of ovum development|down regulation of oogenesis|downregulation of ovum development hbye 2017-01-31T09:31:15Z biological_process owl:Class
GO:0048913 biolink:NamedThing anterior lateral line nerve glial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve. got7fsn_ti biological_process owl:Class
GO:0007382 biolink:NamedThing specification of segmental identity, maxillary segment The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized. got7fsn_ti See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'. biological_process owl:Class
GO:0032968 biolink:NamedThing positive regulation of transcription elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. got7fsn_ti positive regulation of gene-specific transcription elongation from RNA polymerase II promoter|positive regulation of RNA elongation from RNA polymerase II promoter GO:0090040 biological_process owl:Class
GO:0061753 biolink:NamedThing substrate localization to autophagosome The localization process by which an autophagic substrate is delivered to a forming autophagosome. got7fsn_ti substrate sequestration to phagophore|substrate sequestration to autophagosome dph 2015-11-20T11:14:22Z biological_process owl:Class
GO:0061297 biolink:NamedThing positive regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Any process that increases the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. got7fsn_ti positive regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis|positive regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis dph 2010-09-06T09:58:59Z biological_process owl:Class
GO:1903438 biolink:NamedThing positive regulation of mitotic cytokinetic process Any process that activates or increases the frequency, rate or extent of mitotic cytokinetic process. got7fsn_ti activation of mitotic cytokinetic process|upregulation of mitotic cytokinetic process|up-regulation of mitotic cytokinetic process|up regulation of mitotic cytokinetic process tb 2014-09-15T23:11:55Z biological_process owl:Class
CHEBI:67194 biolink:NamedThing got7fsn_ti owl:Class
GO:0061930 biolink:NamedThing regulation of erythrocyte enucleation Any process that modulates the frequency, rate or extent of erythrocyte enucleation. got7fsn_ti dph 2017-09-05T12:48:05Z biological_process owl:Class
GO:0019805 biolink:NamedThing quinolinate biosynthetic process The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid. got7fsn_ti quinolinate formation|quinolinate biosynthesis|quinolinate anabolism|quinolinate synthesis biological_process owl:Class
GO:0032833 biolink:NamedThing negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response. got7fsn_ti downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response|inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response|down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0007558 biolink:NamedThing regulation of juvenile hormone secretion Any process that modulates the frequency, rate or extent of juvenile hormone secretion. got7fsn_ti biological_process owl:Class
GO:0007284 biolink:NamedThing spermatogonial cell division The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes). got7fsn_ti spermatogonium division See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. biological_process owl:Class
GO:0006122 biolink:NamedThing mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. got7fsn_ti complex III (ubiquinone to cytochrome c) biological_process owl:Class
GO:0099631 biolink:NamedThing postsynaptic endocytic zone cytoplasmic component The cytoplasmic component of the postsynaptic endocytic zone. got7fsn_ti postsynaptic endocytic zone cytoplasmic component cellular_component owl:Class
GO:1902672 biolink:NamedThing right anterior basal body Any ciliary basal body that is part of a right anterior flagellum found in Giardia species (trophozoite stage). got7fsn_ti microtubule basal body of right anterior flagellum|ciliary basal body of right anterior flagellum|cilial basal body of right anterior cilium|cilium basal body of right anterior flagellum|ciliary basal body of right anterior cilium|right anterior flagellum ciliary basal body|cilial basal body of right anterior flagellum|microtubule basal body of right anterior cilium|cilium basal body of right anterior cilium Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T14:46:26Z cellular_component owl:Class
GO:0015607 biolink:NamedThing ABC-type fatty-acyl-CoA transporter activity Catalysis of the reaction ATP + H(2)O + fatty acyl CoA(Side 1) <=> ADP + phosphate + fatty acyl CoA(Side 2). A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it. got7fsn_ti ABC-type fatty-acyl-CoA transporter|fatty-acyl-CoA transmembrane transporter activity|fatty acyl CoA transporter activity|fatty-acyl-CoA-transporting ATPase|ATPase-coupled fatty-acyl-CoA transmembrane transporter activity RHEA:15181|EC:7.6.2.4 molecular_function owl:Class
GO:0015916 biolink:NamedThing fatty-acyl-CoA transport The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A). got7fsn_ti fatty acyl-CoA transport|fatty acyl CoA transport|fatty acyl coenzyme A transport biological_process owl:Class
GO:1901974 biolink:NamedThing glycerate transmembrane transporter activity Enables the transfer of glycerate from one side of a membrane to the other. got7fsn_ti ms 2013-03-05T16:48:45Z molecular_function owl:Class
GO:1901975 biolink:NamedThing glycerate transmembrane transport The process in which glycerate is transported across a membrane. got7fsn_ti ms 2013-03-05T16:48:50Z biological_process owl:Class
GO:0015166 biolink:NamedThing polyol transmembrane transporter activity Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol. got7fsn_ti sugar/polyol channel activity Reactome:R-HSA-429571 molecular_function owl:Class
GO:0015791 biolink:NamedThing polyol transport The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0033154 biolink:NamedThing ABC-type oligogalacturonide transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in). got7fsn_ti oligogalacturonide-transporting ATPase activity|oligogalacturonide transmembrane transporter activity|ATP-dependent oligogalacturonide transmembrane transporter activity|ATPase-coupled oligogalacturonide transmembrane transporter activity|oligogalacturonide transporting ATPase activity GO:0033155 TC:3.A.1.1.11 molecular_function owl:Class
GO:0033156 biolink:NamedThing oligogalacturonide transport The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0015568 biolink:NamedThing L-idonate transmembrane transporter activity Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. got7fsn_ti L-idonate/D-gluconate:hydrogen symporter activity molecular_function owl:Class
GO:0015726 biolink:NamedThing L-idonate transmembrane transport The process in which L-idonate is transported across a lipid bilayer, from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose. got7fsn_ti L-idonate transport biological_process owl:Class
GO:0015107 biolink:NamedThing chlorate transmembrane transporter activity Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015702 biolink:NamedThing chlorate transport The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0110033 biolink:NamedThing regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of the adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway, the series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP). got7fsn_ti regulation of adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway kmv 2017-07-17T20:22:20Z biological_process owl:Class
GO:0015795 biolink:NamedThing sorbitol transport The directed movement of sorbitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose. got7fsn_ti glucitol transport biological_process owl:Class
GO:0034315 biolink:NamedThing regulation of Arp2/3 complex-mediated actin nucleation Any process that modulates the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. got7fsn_ti biological_process owl:Class
GO:0086088 biolink:NamedThing voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti dph 2011-11-22T01:32:02Z molecular_function owl:Class
GO:0086051 biolink:NamedThing membrane repolarization during Purkinje myocyte action potential The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. got7fsn_ti dph 2011-11-16T11:51:56Z biological_process owl:Class
GO:0071451 biolink:NamedThing cellular response to superoxide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion. got7fsn_ti mah 2009-12-16T04:39:14Z biological_process owl:Class
UBERON:0002036 biolink:NamedThing got7fsn_ti owl:Class
GO:0060579 biolink:NamedThing ventral spinal cord interneuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a ventral spinal cord interneuron. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. got7fsn_ti dph 2009-05-07T12:21:13Z biological_process owl:Class
GO:0038147 biolink:NamedThing C-X-C motif chemokine 12 receptor activity Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti stromal cell-derived factor-1 receptor activity|CXCL12 receptor activity|SDF-1 receptor activity|CXCR7|CXCR4 bf 2012-05-11T11:32:53Z molecular_function owl:Class
GO:0010968 biolink:NamedThing regulation of microtubule nucleation Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell. got7fsn_ti tb 2009-05-20T11:51:21Z biological_process owl:Class
CHEBI:16991 biolink:NamedThing got7fsn_ti owl:Class
GO:0097151 biolink:NamedThing positive regulation of inhibitory postsynaptic potential Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential. got7fsn_ti positive regulation of inhibitory post-synaptic membrane potential|positive regulation of IPSP pr 2011-08-12T10:07:45Z biological_process owl:Class
GO:2000276 biolink:NamedThing negative regulation of oxidative phosphorylation uncoupler activity Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity. got7fsn_ti negative regulation of mitochondrial uncoupling protein activity|negative regulation of uncoupling protein activity mah 2010-12-07T12:14:59Z biological_process owl:Class
GO:0071052 biolink:NamedThing alpha9-beta1 integrin-ADAM1 complex A protein complex that consists of an alpha9-beta1 integrin complex bound to the transmembrane metallopeptidase ADAM1. got7fsn_ti ITGA9-ITGB1-ADAM1 complex mah 2009-11-03T03:55:15Z cellular_component owl:Class
GO:0003289 biolink:NamedThing atrial septum primum morphogenesis The process in which anatomical structure of an atrial septum primum is generated and organized. got7fsn_ti dph 2009-10-20T10:32:32Z biological_process owl:Class
GO:0002867 biolink:NamedThing regulation of B cell deletion Any process that modulates the frequency, rate, or extent of B cell deletion. got7fsn_ti regulation of B lymphocyte deletion|regulation of B-cell deletion|regulation of B-lymphocyte deletion biological_process owl:Class
GO:0002909 biolink:NamedThing negative regulation of peripheral B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion. got7fsn_ti down-regulation of peripheral B cell deletion|inhibition of peripheral B cell deletion|downregulation of peripheral B cell deletion|down regulation of peripheral B cell deletion biological_process owl:Class
CHEBI:33569 biolink:NamedThing got7fsn_ti owl:Class
GO:0015835 biolink:NamedThing peptidoglycan transport The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti murein transport biological_process owl:Class
GO:2001188 biolink:NamedThing regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Any process that modulates the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell. got7fsn_ti regulation of T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|regulation of T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|regulation of T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell yaf 2011-11-03T01:31:30Z biological_process owl:Class
GO:0110161 biolink:NamedThing positive regulation of mitotic spindle formation (spindle phase one) Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). got7fsn_ti kmv 2019-08-12T15:21:08Z biological_process owl:Class
GO:0030150 biolink:NamedThing protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. got7fsn_ti mitochondrial matrix protein import|mitochondrial translocation|protein transport into mitochondrial matrix biological_process owl:Class
GO:0031382 biolink:NamedThing mating projection formation The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi. got7fsn_ti shmooing|mating projection assembly|mating projection biogenesis biological_process owl:Class
GO:0070165 biolink:NamedThing positive regulation of adiponectin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of adiponectin from a cell. got7fsn_ti up-regulation of adiponectin secretion|activation of adiponectin secretion|stimulation of adiponectin secretion|up regulation of adiponectin secretion|upregulation of adiponectin secretion biological_process owl:Class
GO:0099628 biolink:NamedThing neurotransmitter receptor diffusion trapping The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0009339 biolink:NamedThing glycolate oxidase complex An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN). got7fsn_ti cellular_component owl:Class
GO:0140250 biolink:NamedThing regulation protein catabolic process at synapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. got7fsn_ti https://github.com/geneontology/synapse/issues/204 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T10:34:56Z biological_process owl:Class
GO:0140193 biolink:NamedThing regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Any process that modulates the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. got7fsn_ti pg 2018-02-15T19:08:49Z biological_process owl:Class
GO:1903182 biolink:NamedThing regulation of SUMO transferase activity Any process that modulates the frequency, rate or extent of SUMO ligase activity. got7fsn_ti regulation of SMT3 conjugating enzyme|regulation of SUMO conjugating enzyme activity bf 2014-07-14T14:01:40Z biological_process owl:Class
GO:0048320 biolink:NamedThing axial mesoderm formation The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts. got7fsn_ti biological_process owl:Class
GO:0043159 biolink:NamedThing acrosomal matrix A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction. got7fsn_ti cellular_component owl:Class
GO:1902891 biolink:NamedThing negative regulation of root hair elongation Any process that stops, prevents or reduces the frequency, rate or extent of root hair elongation. got7fsn_ti down regulation of root hair elongation|inhibition of root hair elongation|downregulation of root hair elongation|down-regulation of root hair elongation als 2014-04-07T13:46:47Z biological_process owl:Class
GO:0071731 biolink:NamedThing response to nitric oxide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. got7fsn_ti mah 2010-03-17T04:03:38Z biological_process owl:Class
GO:0035207 biolink:NamedThing negative regulation of hemocyte proliferation Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster. got7fsn_ti inhibition of hemocyte proliferation|down-regulation of hemocyte proliferation|downregulation of hemocyte proliferation|negative regulation of arthropod blood cell proliferation|down regulation of hemocyte proliferation biological_process owl:Class
GO:0034604 biolink:NamedThing pyruvate dehydrogenase (NAD+) activity Catalysis of the reaction: pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH. got7fsn_ti RHEA:28042|KEGG_REACTION:R00209|MetaCyc:PYRUVDEH-RXN molecular_function owl:Class
GO:0009358 biolink:NamedThing polyphosphate kinase complex A protein complex that possesses polyphosphate kinase activity. got7fsn_ti See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'. cellular_component owl:Class
GO:0021567 biolink:NamedThing rhombomere 1 development The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:1901679 biolink:NamedThing nucleotide transmembrane transport The directed movement of nucleotide across a membrane. got7fsn_ti nucleotide membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. pr 2012-11-22T15:43:23Z biological_process owl:Class
GO:2001074 biolink:NamedThing regulation of metanephric ureteric bud development Any process that modulates the frequency, rate or extent of metanephric ureteric bud development. got7fsn_ti yaf 2011-09-14T01:11:06Z biological_process owl:Class
GO:0071403 biolink:NamedThing cellular response to high density lipoprotein particle stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high density lipoprotein particle stimulus. got7fsn_ti response to high density lipoprotein particle stimulus|cellular response to high-density lipoprotein particle stimulus|response to high density lipoprotein particle mah 2009-12-14T02:51:43Z GO:0055099 biological_process owl:Class
GO:0015698 biolink:NamedThing inorganic anion transport The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. got7fsn_ti biological_process owl:Class
GO:1905450 biolink:NamedThing negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Any process that stops, prevents or reduces the frequency, rate or extent of Fc-gamma receptor signaling pathway involved in phagocytosis. got7fsn_ti down-regulation of Fcgamma receptor-mediated phagocytosis|down regulation of Fc gamma receptor-dependent phagocytosis|negative regulation of IgG-mediated phagocytosis|downregulation of Fc-gamma receptor signalling pathway involved in phagocytosis|inhibition of Fc-gamma receptor signalling pathway involved in phagocytosis|down-regulation of Fc gamma receptor-dependent phagocytosis|down regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|inhibition of Fc gamma receptor-dependent phagocytosis|down regulation of Fcgamma receptor-mediated phagocytosis|downregulation of Fc gamma receptor-dependent phagocytosis|inhibition of IgG-mediated phagocytosis|down-regulation of IgG-mediated phagocytosis|down regulation of IgG-mediated phagocytosis|inhibition of Fcgamma receptor-mediated phagocytosis|down-regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|negative regulation of Fc gamma receptor-dependent phagocytosis|downregulation of Fc-gamma receptor signaling pathway involved in phagocytosis|down regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|inhibition of Fc-gamma receptor signaling pathway involved in phagocytosis|downregulation of IgG-mediated phagocytosis|downregulation of Fcgamma receptor-mediated phagocytosis|negative regulation of Fcgamma receptor-mediated phagocytosis|negative regulation of Fc-gamma receptor signalling pathway involved in phagocytosis|down-regulation of Fc-gamma receptor signalling pathway involved in phagocytosis sl 2016-09-15T19:41:58Z biological_process owl:Class
GO:0045898 biolink:NamedThing regulation of RNA polymerase II transcription preinitiation complex assembly Any process that modulates the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. got7fsn_ti regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis|regulation of RNA polymerase II transcriptional pre-initiation complex assembly|regulation of RNA polymerase II transcriptional preinitiation complex formation|regulation of RNA polymerase II transcriptional preinitiation complex assembly biological_process owl:Class
GO:0015434 biolink:NamedThing ABC-type cadmium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole). got7fsn_ti ATPase-coupled cadmium transmembrane transporter activity|cadmium ABC transporter|cadmium-transporting ATPase activity|ATP-dependent cadmium transmembrane transporter activity EC:7.2.2.2|MetaCyc:3.6.3.46-RXN molecular_function owl:Class
GO:0070574 biolink:NamedThing cadmium ion transmembrane transport A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti transmembrane cadmium transport|cadmium ion membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2009-04-20T03:31:47Z biological_process owl:Class
GO:0043020 biolink:NamedThing NADPH oxidase complex A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. got7fsn_ti flavocytochrome b558|respiratory-burst oxidase cellular_component owl:Class
GO:0070778 biolink:NamedThing L-aspartate transmembrane transport The directed movement of L-aspartate across a membrane. got7fsn_ti L-aspartate transport mah 2009-07-02T01:46:31Z GO:0089712 biological_process owl:Class
GO:0072304 biolink:NamedThing regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the metanephros. got7fsn_ti regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|regulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis mah 2010-04-09T05:03:41Z biological_process owl:Class
GO:0071114 biolink:NamedThing alphaV-beta3 integrin-tumstatin complex A protein complex that consists of an alphaV-beta3 integrin complex bound to tumstatin, the NC1 domain of the alpha3 chain of type IV collagen. got7fsn_ti ITGAV-ITGB3-COL4A3 complex mah 2009-11-13T02:18:29Z cellular_component owl:Class
GO:1901969 biolink:NamedThing positive regulation of polynucleotide 3'-phosphatase activity Any process that activates or increases the frequency, rate or extent of polynucleotide 3'-phosphatase activity. got7fsn_ti up-regulation of polynucleotide 3'-phosphatase activity|activation of deoxyribonucleate 3'-phosphatase activity|up-regulation of deoxyribonucleate 3'-phosphatase activity|upregulation of 2'(3')-polynucleotidase activity|activation of DNA 3'-phosphatase activity|up-regulation of 5'-polynucleotidekinase 3'-phosphatase activity|up regulation of 2'(3')-polynucleotidase activity|up-regulation of 2'(3')-polynucleotidase activity|positive regulation of 5'-polynucleotidekinase 3'-phosphatase activity|activation of 2'(3')-polynucleotidase activity|positive regulation of deoxyribonucleate 3'-phosphatase activity|upregulation of polynucleotide 3'-phosphatase activity|upregulation of polynucleotide 3'-phosphohydrolase activity|positive regulation of 2'(3')-polynucleotidase activity|positive regulation of DNA 3'-phosphatase activity|positive regulation of polynucleotide 3'-phosphohydrolase activity|up regulation of deoxyribonucleate 3'-phosphatase activity|activation of polynucleotide 3'-phosphohydrolase activity|activation of 5'-polynucleotidekinase 3'-phosphatase activity|up regulation of DNA 3'-phosphatase activity|up-regulation of polynucleotide 3'-phosphohydrolase activity|up regulation of polynucleotide 3'-phosphatase activity|upregulation of 5'-polynucleotidekinase 3'-phosphatase activity|up regulation of 5'-polynucleotidekinase 3'-phosphatase activity|activation of polynucleotide 3'-phosphatase activity|up-regulation of DNA 3'-phosphatase activity|upregulation of DNA 3'-phosphatase activity|upregulation of deoxyribonucleate 3'-phosphatase activity|up regulation of polynucleotide 3'-phosphohydrolase activity tb 2013-02-22T00:58:31Z biological_process owl:Class
GO:0007390 biolink:NamedThing germ-band shortening The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo. got7fsn_ti germ-band retraction biological_process owl:Class
GO:1901727 biolink:NamedThing positive regulation of histone deacetylase activity Any process that activates or increases the frequency, rate or extent of histone deacetylase activity. got7fsn_ti activation of histone deacetylase activity|up-regulation of histone deacetylase activity|upregulation of histone deacetylase activity|up regulation of histone deacetylase activity rl 2013-01-07T09:14:21Z biological_process owl:Class
GO:0005330 biolink:NamedThing dopamine:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in). got7fsn_ti dopamine:sodium:chloride symporter activity|dopamine transmembrane transporter activity|sodium/dopamine symporter activity https://github.com/geneontology/go-ontology/issues/16054 GO:0005329 molecular_function owl:Class
GO:0046685 biolink:NamedThing response to arsenic-containing substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. got7fsn_ti arsenate sensitivity/resistance|response to arsenic biological_process owl:Class
GO:0060507 biolink:NamedThing epidermal growth factor receptor signaling pathway involved in lung development The series of molecular signals generated as a consequence of an epidermal growth factor-type receptor binding to one of its physiological ligands. This process contributes to lung development. got7fsn_ti epidermal growth factor receptor signalling pathway involved in lung development biological_process owl:Class
GO:0046663 biolink:NamedThing dorsal closure, leading edge cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure. got7fsn_ti biological_process owl:Class
GO:1904763 biolink:NamedThing chaperone-mediated autophagy translocation complex assembly The aggregation, arrangement and bonding together of a set of components to form a chaperone-mediated autophagy translocation complex. got7fsn_ti CMA receptor complex assembly|CMA translocation complex formation|chaperone-mediated autophagy receptor complex assembly|chaperone-mediated autophagy translocation complex formation|CMA receptor complex formation|chaperone-mediated autophagy receptor complex formation|CMA translocation complex assembly pad 2015-10-26T16:34:29Z biological_process owl:Class
GO:0010029 biolink:NamedThing regulation of seed germination Any process that modulates the frequency, rate or extent of seed germination. got7fsn_ti biological_process owl:Class
GO:0015138 biolink:NamedThing fumarate transmembrane transporter activity Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. got7fsn_ti dicarboxylate (succinate/fumarate/malate) antiporter activity molecular_function owl:Class
GO:0015741 biolink:NamedThing fumarate transport The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0060260 biolink:NamedThing regulation of transcription initiation from RNA polymerase II promoter Any process that modulates the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. got7fsn_ti biological_process owl:Class
GO:0014837 biolink:NamedThing myoblast fate determination involved in skeletal muscle regeneration The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
CHEBI:57305 biolink:NamedThing got7fsn_ti owl:Class
GO:0015142 biolink:NamedThing tricarboxylic acid transmembrane transporter activity Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups. got7fsn_ti sodium:dicarboxylate/tricarboxylate symporter activity Reactome:R-HSA-75849|Reactome:R-HSA-372449 molecular_function owl:Class
GO:0035674 biolink:NamedThing tricarboxylic acid transmembrane transport The process in which a tricarboxylic acid is transported across a membrane. got7fsn_ti tricarboxylic acid membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2011-02-08T02:37:31Z biological_process owl:Class
GO:0034632 biolink:NamedThing retinol transmembrane transporter activity Enables the transfer of retinol from one side of a membrane to the other. Retinol is vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. got7fsn_ti vitamin A1 transporter activity|retinol transporter activity Reactome:R-HSA-1467466|Reactome:R-HSA-2466749|Reactome:R-HSA-2466802 molecular_function owl:Class
GO:1902867 biolink:NamedThing negative regulation of retina development in camera-type eye Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye. got7fsn_ti inhibition of retina development in camera-type eye|down-regulation of retina development in camera-type eye|downregulation of retinal development|down-regulation of retina development in camera-style eye|downregulation of retina development in camera-type eye|inhibition of retinal development|down regulation of retinal development|negative regulation of retinal development|downregulation of retina development in camera-style eye|inhibition of retina development in camera-style eye|down regulation of retina development in camera-type eye|negative regulation of retina development in camera-style eye|down-regulation of retinal development|down regulation of retina development in camera-style eye mr 2014-04-03T15:24:23Z biological_process owl:Class
GO:0033288 biolink:NamedThing ATPase-coupled hydroxyectoine transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + hydroxyectoine(out/in) = ADP + phosphate + hydroxyectoine(in/out). got7fsn_ti ATP-dependent hydroxyectoine transmembrane transporter activity|hydroxyectoine transmembrane transporter activity|hydroxyectoine-transporting ATPase activity GO:0033287 molecular_function owl:Class
GO:0033308 biolink:NamedThing hydroxyectoine transport The directed movement of hydroxyectoine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0009504 biolink:NamedThing cell plate The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells. got7fsn_ti Wikipedia:Cell_plate cellular_component owl:Class
GO:0045471 biolink:NamedThing response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. got7fsn_ti GO:0017036 biological_process owl:Class
GO:0048140 biolink:NamedThing male germ-line cyst encapsulation Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the male gonad. got7fsn_ti biological_process owl:Class
GO:0071655 biolink:NamedThing regulation of granulocyte colony-stimulating factor production Any process that modulates the frequency, rate, or extent of production of granulocyte colony-stimulating factor. got7fsn_ti regulation of filgrastim production|regulation of CSF3 production|regulation of G-CSF production|regulation of colony stimulating factor 3 (granulocyte) production|regulation of granulocyte colony stimulating factor production|regulation of lenograstim production|regulation of pluripoietin production mah 2010-02-12T10:41:14Z biological_process owl:Class
GO:1905088 biolink:NamedThing positive regulation of synaptonemal complex assembly Any process that activates or increases the frequency, rate or extent of synaptonemal complex assembly. got7fsn_ti activation of synaptonemal complex assembly|up-regulation of synaptonemal complex assembly|positive regulation of synaptonemal complex formation|upregulation of synaptonemal complex formation|up regulation of synaptonemal complex assembly|upregulation of synaptonemal complex assembly|up-regulation of synaptonemal complex formation|up regulation of synaptonemal complex formation|activation of synaptonemal complex formation mec 2016-03-30T08:39:03Z biological_process owl:Class
GO:0048938 biolink:NamedThing lateral line nerve glial cell morphogenesis involved in differentiation The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve. got7fsn_ti biological_process owl:Class
GO:1904237 biolink:NamedThing positive regulation of substrate-dependent cell migration, cell attachment to substrate Any process that activates or increases the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. got7fsn_ti up regulation of substrate-dependent cell migration, cell attachment to substrate|positive regulation of substrate-bound cell migration, cell attachment to substrate|up-regulation of substrate-bound cell migration, cell attachment to substrate|activation of substrate-bound cell migration, cell attachment to substrate|up-regulation of substrate-dependent cell migration, cell attachment to substrate|upregulation of substrate-bound cell migration, cell attachment to substrate|activation of substrate-dependent cell migration, cell attachment to substrate|upregulation of substrate-dependent cell migration, cell attachment to substrate|up regulation of substrate-bound cell migration, cell attachment to substrate pga 2015-05-15T13:30:11Z biological_process owl:Class
GO:0006448 biolink:NamedThing regulation of translational elongation Any process that modulates the frequency, rate, extent or accuracy of translational elongation. got7fsn_ti biological_process owl:Class
GO:0032412 biolink:NamedThing regulation of ion transmembrane transporter activity Any process that modulates the activity of an ion transporter. got7fsn_ti regulation of ion transporter activity biological_process owl:Class
GO:0062056 biolink:NamedThing compound eye pigment cell differentiation The process in which a relatively unspecialized cell acquires the specialized features of a compound eye pigment cell, a cell of the retina containing screening pigments that functions to screen photoreceptors from light leaking from adjacent ommatidia. got7fsn_ti dph 2018-08-01T12:59:42Z biological_process owl:Class
GO:0043323 biolink:NamedThing positive regulation of natural killer cell degranulation Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation. got7fsn_ti up regulation of natural killer cell degranulation|upregulation of natural killer cell degranulation|positive regulation of NK cell granule exocytosis|positive regulation of natural killer cell granule exocytosis|up-regulation of natural killer cell degranulation|stimulation of natural killer cell degranulation|activation of natural killer cell degranulation|positive regulation of NK cell degranulation biological_process owl:Class
GO:0000127 biolink:NamedThing transcription factor TFIIIC complex A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions. got7fsn_ti cellular_component owl:Class
GO:0060673 biolink:NamedThing cell-cell signaling involved in placenta development Any process that mediates the transfer of information from one cell to another. got7fsn_ti cell-cell signalling involved in placenta development dph 2009-06-02T12:58:03Z biological_process owl:Class
GO:0032828 biolink:NamedThing positive regulation of natural killer cell differentiation involved in immune response Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response. got7fsn_ti upregulation of natural killer cell differentiation during immune response|stimulation of natural killer cell differentiation during immune response|positive regulation of natural killer cell differentiation during immune response|positive regulation of natural killer cell development involved in immune response|up regulation of natural killer cell differentiation during immune response|positive regulation of NK cell differentiation during immune response|up-regulation of natural killer cell differentiation during immune response|activation of natural killer cell differentiation during immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0031282 biolink:NamedThing regulation of guanylate cyclase activity Any process that modulates the frequency, rate or extent of guanylate cyclase activity. got7fsn_ti biological_process owl:Class
GO:0033027 biolink:NamedThing positive regulation of mast cell apoptotic process Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process. got7fsn_ti upregulation of mast cell apoptosis|up regulation of mast cell apoptosis|stimulation of mast cell apoptosis|positive regulation of mast cell apoptosis|activation of mast cell apoptosis|up-regulation of mast cell apoptosis biological_process owl:Class
GO:0032827 biolink:NamedThing negative regulation of natural killer cell differentiation involved in immune response Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response. got7fsn_ti negative regulation of NK cell differentiation during immune response|down regulation of natural killer cell differentiation during immune response|negative regulation of natural killer cell differentiation during immune response|down-regulation of natural killer cell differentiation during immune response|downregulation of natural killer cell differentiation during immune response|negative regulation of natural killer cell development involved in immune response|inhibition of natural killer cell differentiation during immune response Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0061152 biolink:NamedThing trachea submucosa development The progression of the trachea submucosa over time from its formation to the mature structure. The trachea submucosa is made up of the glands and elastic tissue that lie under the mucosa in the trachea. got7fsn_ti dph 2010-06-07T09:58:40Z biological_process owl:Class
GO:0015220 biolink:NamedThing choline transmembrane transporter activity Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. got7fsn_ti choline permease activity|amino acid/choline transmembrane transporter activity GO:0005306 Reactome:R-HSA-6797956|Reactome:R-HSA-429594|Reactome:R-HSA-5658483|Reactome:R-HSA-444433 molecular_function owl:Class
PO:0025166 biolink:NamedThing got7fsn_ti owl:Class
GO:0006839 biolink:NamedThing mitochondrial transport Transport of substances into, out of or within a mitochondrion. got7fsn_ti mitochondrial alpha-ketoglutarate/malate transport|mitochondrial sodium/calcium ion exchange|mitochondrial aspartate/glutamate transport biological_process owl:Class
GO:0099585 biolink:NamedThing release of sequestered calcium ion into presynaptic cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol. got7fsn_ti biological_process owl:Class
GO:2000300 biolink:NamedThing regulation of synaptic vesicle exocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. got7fsn_ti dph 2011-01-03T08:20:40Z biological_process owl:Class
GO:0008193 biolink:NamedThing tRNA guanylyltransferase activity Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. got7fsn_ti EC:2.7.7.79|RHEA:54564 molecular_function owl:Class
GO:0099116 biolink:NamedThing tRNA 5'-end processing The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA. got7fsn_ti tRNA 5' processing biological_process owl:Class
GO:0090158 biolink:NamedThing endoplasmic reticulum membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane. got7fsn_ti endoplasmic reticulum membrane organisation tb 2009-12-08T08:27:17Z biological_process owl:Class
GO:1904303 biolink:NamedThing positive regulation of maternal process involved in parturition Any process that activates or increases the frequency, rate or extent of maternal process involved in parturition. got7fsn_ti up regulation of maternal process involved in parturition|upregulation of maternal process involved in parturition|up-regulation of maternal process involved in parturition|activation of maternal process involved in parturition sl 2015-06-09T23:01:45Z biological_process owl:Class
GO:1904748 biolink:NamedThing regulation of apoptotic process involved in development Any process that modulates the frequency, rate or extent of apoptotic process involved in development. got7fsn_ti regulation of programmed cell death by apoptosis involved in anatomical structure development|regulation of apoptosis involved in anatomical structure development|regulation of apoptotic programmed cell death involved in anatomical structure development|regulation of apoptotic cell death involved in anatomical structure development|regulation of type I programmed cell death involved in anatomical structure development|regulation of apoptotic programmed cell death involved in development of an anatomical structure|regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|regulation of induction of apoptosis by p53 involved in anatomical structure development|regulation of induction of apoptosis involved in development of an anatomical structure|regulation of apoptosis signaling involved in development of an anatomical structure|regulation of type I programmed cell death involved in development of an anatomical structure|regulation of apoptotic program involved in anatomical structure development|regulation of activation of apoptosis involved in development of an anatomical structure|regulation of apoptosis activator activity involved in anatomical structure development|regulation of activation of apoptosis involved in anatomical structure development|regulation of apoptosis signaling involved in anatomical structure development|regulation of apoptotic program involved in development of an anatomical structure|regulation of apoptotic process involved in anatomical structure development|regulation of induction of apoptosis involved in anatomical structure development|regulation of apoptosis involved in development of an anatomical structure|regulation of apoptosis activator activity involved in development of an anatomical structure|regulation of apoptotic process involved in development of an anatomical structure|regulation of commitment to apoptosis involved in anatomical structure development|regulation of commitment to apoptosis involved in development of an anatomical structure|regulation of programmed cell death by apoptosis involved in development of an anatomical structure|regulation of apoptotic cell death involved in development of an anatomical structure|regulation of induction of apoptosis by p53 involved in development of an anatomical structure|regulation of signaling (initiator) caspase activity involved in anatomical structure development Q10943 in PMID:22801495, inferred from mutant phenotype es 2015-10-19T15:02:28Z biological_process owl:Class
GO:0002805 biolink:NamedThing regulation of antimicrobial peptide biosynthetic process Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis. got7fsn_ti biological_process owl:Class
GO:0070436 biolink:NamedThing Grb2-EGFR complex A protein complex that contains the epidermal growth factor receptor (EGFR) and Grb2, and is involved in linking EGFR activation to the p21-Ras pathway. got7fsn_ti Grb2-Egfr complex, EGF stimulated cellular_component owl:Class
GO:0015154 biolink:NamedThing disaccharide transmembrane transporter activity Enables the transfer of disaccharide from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015766 biolink:NamedThing disaccharide transport The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units. got7fsn_ti biological_process owl:Class
GO:1903236 biolink:NamedThing regulation of leukocyte tethering or rolling Any process that modulates the frequency, rate or extent of leukocyte tethering or rolling. got7fsn_ti als 2014-07-31T13:07:48Z biological_process owl:Class
GO:1905916 biolink:NamedThing negative regulation of cell differentiation involved in phenotypic switching Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation involved in phenotypic switching. got7fsn_ti down-regulation of cell differentiation involved in phenotypic switching|inhibition of cell differentiation involved in phenotypic switching|downregulation of cell differentiation involved in phenotypic switching|down regulation of cell differentiation involved in phenotypic switching rph 2017-02-08T12:23:23Z biological_process owl:Class
GO:0007393 biolink:NamedThing dorsal closure, leading edge cell fate determination The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed. got7fsn_ti biological_process owl:Class
GO:0035029 biolink:NamedThing dorsal closure, leading edge cell fate commitment The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis. got7fsn_ti biological_process owl:Class
GO:0140199 biolink:NamedThing negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process. got7fsn_ti pg 2018-02-15T19:31:23Z biological_process owl:Class
GO:0010082 biolink:NamedThing regulation of root meristem growth Any process involved in maintaining the size and shape of a root meristem. got7fsn_ti regulation of root meristem size biological_process owl:Class
GO:1902120 biolink:NamedThing negative regulation of meiotic spindle elongation Any process that stops, prevents or reduces the frequency, rate or extent of meiotic spindle elongation. got7fsn_ti inhibition of meiotic spindle elongation|down-regulation of meiotic spindle elongation|negative regulation of spindle elongation during meiosis|downregulation of spindle elongation during meiosis|down-regulation of spindle elongation during meiosis|inhibition of spindle elongation during meiosis|down regulation of spindle elongation during meiosis|down regulation of meiotic spindle elongation|downregulation of meiotic spindle elongation al 2013-05-15T15:15:53Z biological_process owl:Class
GO:0120231 biolink:NamedThing DNA recombinase auxiliary factor complex A protein complex that binds to a recombinase and incrseases its activity. got7fsn_ti DNA recombinase activator complex|DNA recombinase accessory factor complex https://github.com/geneontology/go-ontology/issues/19631 krc 2020-06-18T16:12:52Z cellular_component owl:Class
GO:1902177 biolink:NamedThing positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway. got7fsn_ti upregulation of intrinsic apoptotic signaling pathway in response to oxidative stress|up regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|positive regulation of intrinsic apoptotic signaling pathway in response to oxidative stress|activation of intrinsic apoptotic signaling pathway in response to oxidative stress|up-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress pr 2013-05-29T18:30:10Z biological_process owl:Class
GO:0070126 biolink:NamedThing mitochondrial translational termination The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa). got7fsn_ti mitochondrial translation termination biological_process owl:Class
GO:0007021 biolink:NamedThing tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. got7fsn_ti tubulin-specific chaperone activity|tubulin assembly|tubulin folding biological_process owl:Class
GO:1901201 biolink:NamedThing regulation of extracellular matrix assembly Any process that modulates the frequency, rate or extent of extracellular matrix assembly. got7fsn_ti rl 2012-07-27T04:04:00Z biological_process owl:Class
CHEBI:59905 biolink:NamedThing got7fsn_ti owl:Class
GO:0006297 biolink:NamedThing nucleotide-excision repair, DNA gap filling Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes. got7fsn_ti biological_process owl:Class
GO:0038194 biolink:NamedThing thyroid-stimulating hormone signaling pathway The series of molecular signals generated as a consequence of thyroid-stimulating hormone (thyrotropin) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti thyrotropin signaling pathway|TSH signaling pathway bf 2013-10-28T09:03:48Z biological_process owl:Class
GO:1905198 biolink:NamedThing manchette assembly The aggregation, arrangement and bonding together of a set of components to form a manchette. got7fsn_ti manchette formation krc 2016-05-12T15:19:08Z biological_process owl:Class
GO:0061221 biolink:NamedThing mesonephric mesenchyme morphogenesis The process in which the anatomical structures of a mesonephric mesenchymal tissue are generated and organized. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros. got7fsn_ti dph 2010-08-19T01:17:38Z biological_process owl:Class
GO:1902959 biolink:NamedThing regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Any process that modulates the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. got7fsn_ti regulation of aspartic protease activity involved in amyloid precursor protein catabolism|regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|regulation of aspartate protease activity involved in amyloid precursor protein breakdown|regulation of aspartyl protease activity involved in amyloid precursor protein degradation|regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|regulation of aspartate protease activity involved in amyloid precursor protein catabolism|regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|regulation of aspartic protease activity involved in amyloid precursor protein breakdown|regulation of aspartyl protease activity involved in APP catabolism|regulation of aspartic protease activity involved in APP catabolism|regulation of aspartic endopeptidase activity involved in APP catabolic process|regulation of aspartic-type endopeptidase activity involved in APP catabolism|regulation of aspartic protease activity involved in APP catabolic process|regulation of carboxyl protease activity involved in APP catabolism|regulation of aspartate protease activity involved in APP catabolism|regulation of aspartic endopeptidase activity involved in APP catabolism|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|regulation of aspartate protease activity involved in APP catabolic process|regulation of aspartyl protease activity involved in APP catabolic process|regulation of carboxyl protease activity involved in amyloid precursor protein degradation|regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|regulation of aspartic-type endopeptidase activity involved in APP catabolic process|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|regulation of carboxyl protease activity involved in APP catabolic process|regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|regulation of aspartic protease activity involved in amyloid precursor protein degradation|regulation of aspartate protease activity involved in amyloid precursor protein degradation sjp 2014-05-06T09:07:04Z biological_process owl:Class
GO:0015056 biolink:NamedThing corticotrophin-releasing factor receptor activity Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0071376 biolink:NamedThing cellular response to corticotropin-releasing hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response. got7fsn_ti cellular response to corticoliberin stimulus|cellular response to corticotropin-releasing factor stimulus|cellular response to CRH stimulus|cellular response to CRF stimulus mah 2009-12-11T03:24:56Z biological_process owl:Class
GO:0098877 biolink:NamedThing neurotransmitter receptor transport to plasma membrane The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles. got7fsn_ti biological_process owl:Class
GO:0005968 biolink:NamedThing Rab-protein geranylgeranyltransferase complex An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein). got7fsn_ti RAB-protein geranylgeranyltransferase complex|RabGGTase complex|Rab geranylgeranyltransferase complex|GGTase-II complex cellular_component owl:Class
GO:0090192 biolink:NamedThing regulation of glomerulus development Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. got7fsn_ti tb 2009-12-18T11:17:13Z biological_process owl:Class
GO:1905903 biolink:NamedThing negative regulation of mesoderm formation Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation. got7fsn_ti downregulation of mesoderm formation|down-regulation of mesoderm formation|inhibition of mesoderm formation|down regulation of mesoderm formation rph 2017-02-03T12:28:29Z biological_process owl:Class
CL:0000092 biolink:NamedThing got7fsn_ti owl:Class
GO:0030700 biolink:NamedThing glycine reductase complex Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C. got7fsn_ti Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'. cellular_component owl:Class
GO:0071242 biolink:NamedThing cellular response to ammonium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. got7fsn_ti cellular response to ammonia mah 2009-12-03T02:39:40Z GO:1903718 biological_process owl:Class
GO:0015436 biolink:NamedThing ABC-type capsular-polysaccharide transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out). got7fsn_ti capsular-polysaccharide-transporting ATPase activity|ATPase-coupled capsular-polysaccharide transporter activity|ATP-dependent capsular-polysaccharide transporter activity|capsular-polysaccharide ABC transporter|ATP phosphohydrolase (capsular-polysaccharide-exporting) MetaCyc:3.6.3.38-RXN|EC:7.6.2.12 molecular_function owl:Class
GO:0001583 biolink:NamedThing detection of chemical stimulus involved in sensory perception of salty taste The series of events required for a salty taste stimulus to be received and converted to a molecular signal. got7fsn_ti sensory detection of chemical stimulus during perception of salty taste|perception of salty taste, detection of chemical stimulus|sensory transduction of salty taste|perception of salty taste, sensory transduction of chemical stimulus|salty taste detection|sensory detection of salty taste|sensory transduction of chemical stimulus during perception of salty taste biological_process owl:Class
GO:0048492 biolink:NamedThing ribulose bisphosphate carboxylase complex A complex containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. got7fsn_ti RubisCO complex cellular_component owl:Class
GO:0042933 biolink:NamedThing chrysobactin transmembrane transporter activity Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) from one side of a membrane to the other. got7fsn_ti chrysobactin transporter activity molecular_function owl:Class
GO:0038029 biolink:NamedThing epidermal growth factor receptor signaling pathway via MAPK cascade The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on via the MAPKKK cascade. got7fsn_ti EGFR signaling pathway via MAPKKK cascade|epidermal growth factor receptor signalling pathway via MAPKKK cascade|epidermal growth factor receptor signaling pathway via MAPKKK cascade|EGFR/MAPK signaling|EGFR signaling via MAPKKK cascade bf 2011-09-08T10:53:01Z biological_process owl:Class
GO:1904235 biolink:NamedThing regulation of substrate-dependent cell migration, cell attachment to substrate Any process that modulates the frequency, rate or extent of substrate-dependent cell migration, cell attachment to substrate. got7fsn_ti regulation of substrate-bound cell migration, cell attachment to substrate pga 2015-05-15T13:29:59Z biological_process owl:Class
GO:0098585 biolink:NamedThing host cell synaptic vesicle membrane The lipid bilayer surrounding a host synaptic vesicle. got7fsn_ti dos 2014-01-24T13:15:14Z cellular_component owl:Class
GO:0098004 biolink:NamedThing virus tail fiber assembly The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber. got7fsn_ti bm 2012-07-18T16:08:15Z biological_process owl:Class
GO:0098652 biolink:NamedThing collagen type VII anchoring fibril An antiparallel dimer of two collagen VII trimers, one end of which is embedded in the lamina densa while the other end attaches to banded collagen fibrils in the dermis. got7fsn_ti cellular_component owl:Class
GO:0030302 biolink:NamedThing deoxynucleotide transport The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell. got7fsn_ti biological_process owl:Class
GO:0003367 biolink:NamedThing cell-cell adhesion involved in ameboidal cell migration The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells. got7fsn_ti dph 2009-12-08T05:15:49Z biological_process owl:Class
GO:0003365 biolink:NamedThing establishment of cell polarity involved in ameboidal cell migration The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell. got7fsn_ti dph 2009-12-08T04:50:41Z biological_process owl:Class
GO:0033041 biolink:NamedThing sweet taste receptor activity Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste. got7fsn_ti molecular_function owl:Class
GO:0001582 biolink:NamedThing detection of chemical stimulus involved in sensory perception of sweet taste The series of events required for a sweet taste stimulus to be received and converted to a molecular signal. got7fsn_ti perception of sweet taste, sensory transduction of chemical stimulus|sensory transduction of chemical stimulus during perception of sweet taste|sweet taste detection|sensory detection of sweet taste|sensory detection of chemical stimulus during perception of sweet taste|perception of sweet taste, detection of chemical stimulus|sensory transduction of sweet taste biological_process owl:Class
GO:0004867 biolink:NamedThing serine-type endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. got7fsn_ti serine protease inhibitor activity|serine proteinase inhibitor activity|serpin activity Reactome:R-HSA-159001|Reactome:R-HSA-158795|Reactome:R-HSA-158893|Reactome:R-HSA-158800|Reactome:R-HSA-159005 molecular_function owl:Class
GO:0033284 biolink:NamedThing ATPase-coupled carboxylic acid transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carboxylic acid(out/in) = ADP + phosphate + carboxylic acid(in/out). got7fsn_ti ATP-dependent carboxylic acid transporter activity|carboxylic acid-transporting ATPase activity molecular_function owl:Class
GO:2001193 biolink:NamedThing positive regulation of gamma-delta T cell activation involved in immune response Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response. got7fsn_ti positive regulation of gamma-delta T lymphocyte activation during immune response|positive regulation of gamma-delta T cell activation during immune response|positive regulation of gamma-delta T-lymphocyte activation during immune response|positive regulation of gamma-delta T-cell activation during immune response yaf 2011-11-03T04:28:48Z biological_process owl:Class
GO:0021965 biolink:NamedThing spinal cord ventral commissure morphogenesis The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized. got7fsn_ti biological_process owl:Class
GO:0048133 biolink:NamedThing male germ-line stem cell asymmetric division The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes. got7fsn_ti male germ-line stem cell renewal biological_process owl:Class
GO:1901998 biolink:NamedThing toxin transport The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti dph 2013-03-19T19:24:55Z biological_process owl:Class
GO:0071395 biolink:NamedThing cellular response to jasmonic acid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. got7fsn_ti mah 2009-12-11T04:13:34Z biological_process owl:Class
GO:0038158 biolink:NamedThing granulocyte colony-stimulating factor signaling pathway A series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R). got7fsn_ti CSF3 signaling pathway|G-CSF receptor signaling pathway|G-CSF signaling pathway|granulocyte colony-stimulating factor signalling pathway|granulocyte colony-stimulating factor receptor signaling pathway bf 2012-05-14T01:30:28Z biological_process owl:Class
GO:0060700 biolink:NamedThing regulation of ribonuclease activity Any process that modulates the rate, frequency, or extent of ribonuclease activity, catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. got7fsn_ti dph 2009-06-08T02:45:46Z biological_process owl:Class
GO:0098706 biolink:NamedThing iron ion import across cell outer membrane The directed movement of iron ions from outside of a cell, across the cell outer membrane and into the periplasmic space. got7fsn_ti high-affinity ferric iron transmembrane transport|ferric iron import across cell outer membrane|high affinity ferric iron transport|ferric iron transmembrane transport|ferric ion import into cell|ferric iron import into cell pr 2012-12-20T08:33:03Z GO:0015683|GO:0097461 biological_process owl:Class
GO:0007040 biolink:NamedThing lysosome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases. got7fsn_ti lysosome organization and biogenesis|lysosome organisation biological_process owl:Class
GO:0001658 biolink:NamedThing branching involved in ureteric bud morphogenesis The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules. got7fsn_ti ureteric bud branching biological_process owl:Class
GO:0007038 biolink:NamedThing endocytosed protein transport to vacuole The directed movement of proteins imported into a cell by endocytosis to the vacuole. got7fsn_ti delivery of endocytosed proteins to the vacuole See also the biological process term 'endocytosis ; GO:0006897'. biological_process owl:Class
NCBITaxon:58024 biolink:NamedThing got7fsn_ti owl:Class
GO:0034228 biolink:NamedThing ethanolamine transmembrane transporter activity Enables the transfer of ethanolamine from one side of a membrane to the other. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. got7fsn_ti 2-aminoethanol transmembrane transporter activity|ethanolamine permease activity|monoethanolamine transmembrane transporter activity RHEA:32747 molecular_function owl:Class
GO:0034229 biolink:NamedThing ethanolamine transport The directed movement of ethanolamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ethanolamine (2-aminoethanol, monoethanolamine) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids, such as phosphatidylethanolamine. got7fsn_ti 2-aminoethanol transport|monoethanolamine transport biological_process owl:Class
GO:0008035 biolink:NamedThing high-density lipoprotein particle binding Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. got7fsn_ti HDL binding molecular_function owl:Class
GO:0071423 biolink:NamedThing malate transmembrane transport A process in which a malate ion is transported across a membrane. got7fsn_ti malate membrane transport|transmembrane malate transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2009-12-15T03:31:37Z biological_process owl:Class
GO:0061135 biolink:NamedThing endopeptidase regulator activity Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. got7fsn_ti dph 2010-05-17T01:19:36Z molecular_function owl:Class
GO:0052548 biolink:NamedThing regulation of endopeptidase activity Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. got7fsn_ti protease regulator activity biological_process owl:Class
GO:0008199 biolink:NamedThing ferric iron binding Binding to a ferric iron ion, Fe(III). got7fsn_ti molecular_function owl:Class
GO:0099179 biolink:NamedThing regulation of synaptic membrane adhesion Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes. got7fsn_ti regulation of synapse adhesion between pre- and post-synapse biological_process owl:Class
GO:1903740 biolink:NamedThing positive regulation of phosphatidate phosphatase activity Any process that activates or increases the frequency, rate or extent of phosphatidate phosphatase activity. got7fsn_ti up-regulation of phosphatidic acid phosphatase activity|activation of phosphatic acid phosphatase activity|positive regulation of phosphatidic acid phosphatase activity|up-regulation of 3-sn-phosphatidate phosphohydrolase activity|up regulation of 3-sn-phosphatidate phosphohydrolase activity|up-regulation of phosphatic acid phosphohydrolase activity|up-regulation of phosphatidate phosphohydrolase activity|activation of phosphatidate phosphohydrolase activity|up regulation of phosphatic acid phosphatase activity|activation of phosphatidate phosphatase activity|up-regulation of phosphatic acid phosphatase activity|up regulation of phosphatidate phosphatase activity|upregulation of phosphatidic acid phosphatase activity|positive regulation of phosphatic acid phosphatase activity|positive regulation of 3-sn-phosphatidate phosphohydrolase activity|up regulation of phosphatidic acid phosphatase activity|up regulation of phosphatic acid phosphohydrolase activity|up regulation of phosphatidate phosphohydrolase activity|upregulation of phosphatic acid phosphohydrolase activity|upregulation of acid phosphatidyl phosphatase activity|activation of phosphatic acid phosphohydrolase activity|upregulation of 3-sn-phosphatidate phosphohydrolase activity|positive regulation of phosphatidate phosphohydrolase activity|up-regulation of acid phosphatidyl phosphatase activity|activation of 3-sn-phosphatidate phosphohydrolase activity|positive regulation of phosphatic acid phosphohydrolase activity|positive regulation of acid phosphatidyl phosphatase activity|up regulation of acid phosphatidyl phosphatase activity|activation of acid phosphatidyl phosphatase activity|upregulation of phosphatic acid phosphatase activity|activation of phosphatidic acid phosphatase activity|upregulation of phosphatidate phosphohydrolase activity|upregulation of phosphatidate phosphatase activity|up-regulation of phosphatidate phosphatase activity tb 2014-12-11T23:37:44Z biological_process owl:Class
GO:0010867 biolink:NamedThing positive regulation of triglyceride biosynthetic process Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. got7fsn_ti positive regulation of triacylglycerol biosynthetic process biological_process owl:Class
GO:0009999 biolink:NamedThing negative regulation of auditory receptor cell fate specification Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell. got7fsn_ti suppression of auditory receptor cell fate|downregulation of auditory receptor cell fate specification|down regulation of auditory receptor cell fate specification|suppression of hair cell fate|down-regulation of auditory receptor cell fate specification|inhibition of auditory receptor cell fate specification|negative regulation of auditory hair cell fate specification biological_process owl:Class
GO:0015796 biolink:NamedThing galactitol transport The directed movement of galactitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose. got7fsn_ti biological_process owl:Class
GO:0060301 biolink:NamedThing positive regulation of cytokine activity Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells. got7fsn_ti biological_process owl:Class
GO:0045249 biolink:NamedThing cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. got7fsn_ti See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. cellular_component owl:Class
GO:0015593 biolink:NamedThing allose transmembrane transporter activity Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3. got7fsn_ti molecular_function owl:Class
GO:1903200 biolink:NamedThing positive regulation of L-dopa decarboxylase activity Any process that activates or increases the frequency, rate or extent of L-dopa decarboxylase activity. got7fsn_ti up-regulation of DDC activity|activation of DOPA decarboxylase activity|up-regulation of DOPA decarboxylase activity|positive regulation of DOPA decarboxylase activity|upregulation of L-dopa decarboxylase activity|activation of DDC activity|up-regulation of L-dopa decarboxylase activity|up regulation of L-dopa decarboxylase activity|activation of L-dopa decarboxylase activity|up regulation of DDC activity|positive regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|up-regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|upregulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|activation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|upregulation of DOPA decarboxylase activity|upregulation of DDC activity|positive regulation of DDC activity|up regulation of 4-dihydroxyl-L-phenylalanine decarboxylase activity|up regulation of DOPA decarboxylase activity bf 2014-07-21T09:32:43Z biological_process owl:Class
GO:1901371 biolink:NamedThing regulation of leaf morphogenesis Any process that modulates the frequency, rate or extent of leaf morphogenesis. got7fsn_ti tb 2012-09-24T23:07:17Z biological_process owl:Class
GO:0022035 biolink:NamedThing rhombomere cell migration The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere. got7fsn_ti biological_process owl:Class
GO:0015173 biolink:NamedThing aromatic amino acid transmembrane transporter activity Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. got7fsn_ti aromatic amino acid transporter activity|hydroxy/aromatic amino acid permease activity|valine/tyrosine/tryptophan permease activity molecular_function owl:Class
GO:0015801 biolink:NamedThing aromatic amino acid transport The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0043384 biolink:NamedThing pre-T cell receptor complex A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins. got7fsn_ti pre-T-lymphocyte receptor complex|pre-T-cell receptor complex|pre-TCR complex|pre-T lymphocyte receptor complex cellular_component owl:Class
GO:0033616 biolink:NamedThing plasma membrane proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0048201 biolink:NamedThing vesicle targeting, plasma membrane to endosome The process in which vesicles formed at the plasma membrane are directed to specific destinations in endosome membranes, mediated by molecules at the vesicle membrane and target membrane surfaces. got7fsn_ti plasma membrane to endosome targeting biological_process owl:Class
GO:0045592 biolink:NamedThing regulation of cumulus cell differentiation Any process that modulates the frequency, rate or extent of ovarian cumulus cell differentiation. got7fsn_ti regulation of ovarian cumulus cell differentiation biological_process owl:Class
GO:0003922 biolink:NamedThing GMP synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+). got7fsn_ti xanthosine 5'-phosphate amidotransferase activity|guanylate synthetase (glutamine-hydrolyzing)|GMP synthetase (glutamine-hydrolysing)|GMP synthetase (glutamine-hydrolyzing) activity|xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)|guanosine monophosphate synthetase (glutamine-hydrolyzing)|guanosine 5'-monophosphate synthetase activity|glutamine amidotransferase activity|GMP synthase (glutamine-hydrolysing) EC:6.3.5.2|Reactome:R-HSA-73792|MetaCyc:GMP-SYN-GLUT-RXN|RHEA:11680|Wikipedia:GMP_synthase_(glutamine-hydrolysing) molecular_function owl:Class
GO:0061682 biolink:NamedThing seminal vesicle morphogenesis The process in which the anatomical structures of a seminal vesicle are generated and organized. got7fsn_ti dph 2015-03-04T13:33:49Z biological_process owl:Class
GO:0062235 biolink:NamedThing axonemal basal plate assembly The aggregation, arrangement and bonding together of a set of components to form an axonemal basal plate. got7fsn_ti axoneme basal plate assembly|axonemal basal plate formation|basal plate assembly dph 2020-04-16T12:21:35Z biological_process owl:Class
CL:0000084 biolink:NamedThing got7fsn_ti owl:Class
GO:0014030 biolink:NamedThing mesenchymal cell fate commitment The process in which a cell becomes committed to become a mesenchymal cell. got7fsn_ti biological_process owl:Class
GO:0097113 biolink:NamedThing AMPA glutamate receptor clustering The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane. got7fsn_ti alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|AMPA receptor clustering pr 2011-07-31T05:25:53Z biological_process owl:Class
GO:0004866 biolink:NamedThing endopeptidase inhibitor activity Binds to and stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. got7fsn_ti endoproteinase inhibitor|proteinase inhibitor|alpha-2 macroglobulin molecular_function owl:Class
GO:0010951 biolink:NamedThing negative regulation of endopeptidase activity Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. got7fsn_ti tb 2009-04-27T11:47:01Z biological_process owl:Class
GO:0005642 biolink:NamedThing annulate lamellae Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER. got7fsn_ti cellular_component owl:Class
GO:0039638 biolink:NamedThing lipopolysaccharide-mediated virion attachment to host cell The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface. got7fsn_ti LPS binding involved in viral attachment to host cell|lipopolysaccharide binding involved in viral attachment to host cell|virion attachment, binding to host lipopolysaccharide bf 2012-08-17T10:13:06Z biological_process owl:Class
GO:1903724 biolink:NamedThing positive regulation of centriole elongation Any process that activates or increases the frequency, rate or extent of centriole elongation. got7fsn_ti upregulation of centriole elongation|up-regulation of centriole elongation|up regulation of centriole elongation|activation of centriole elongation als 2014-12-09T16:36:20Z biological_process owl:Class
GO:0060049 biolink:NamedThing regulation of protein glycosylation Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. got7fsn_ti regulation of protein amino acid glycosylation biological_process owl:Class
GO:1904382 biolink:NamedThing mannose trimming involved in glycoprotein ERAD pathway The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein that occurs as part of glycoprotein ER-associated glycoprotein degradation (gpERAD). got7fsn_ti glycoprotein mannose trimming involved in gpERAD|protein alpha-1,2-demannosylation involved in gpERAD|glycoprotein mannose trimming involved in glycoprotein ERAD|protein alpha-1,2-demannosylation involved in glycoprotein ERAD pathway|glycoprotein mannose trimming involved in ER-associated glycoprotein degradation|protein alpha-1,2-demannosylation involved in ER-associated glycoprotein degradation|mannose trimming involved in misfolded or incompletely synthesized glycoprotein catabolic process|protein alpha-1,2-demannosylation involved in glycoprotein ERAD|glycoprotein mannose trimming involved in glycoprotein ERAD pathway bf 2015-06-23T09:46:55Z biological_process owl:Class
GO:1902960 biolink:NamedThing negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process. got7fsn_ti downregulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|down regulation of aspartic endopeptidase activity involved in APP catabolic process|inhibition of aspartate protease activity involved in amyloid precursor protein breakdown|downregulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|down-regulation of aspartate protease activity involved in amyloid precursor protein breakdown|inhibition of aspartic endopeptidase activity involved in APP catabolism|negative regulation of aspartic protease activity involved in APP catabolism|negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|inhibition of aspartate protease activity involved in amyloid precursor protein degradation|downregulation of aspartate protease activity involved in amyloid precursor protein catabolism|inhibition of aspartic protease activity involved in APP catabolism|down regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|negative regulation of aspartyl protease activity involved in amyloid precursor protein degradation|down regulation of aspartyl protease activity involved in APP catabolism|negative regulation of carboxyl protease activity involved in APP catabolism|negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of aspartic-type endopeptidase activity involved in APP catabolism|inhibition of aspartate protease activity involved in amyloid precursor protein catabolism|down regulation of carboxyl protease activity involved in APP catabolic process|downregulation of aspartic protease activity involved in APP catabolic process|inhibition of aspartyl protease activity involved in APP catabolism|down regulation of aspartic protease activity involved in APP catabolic process|downregulation of carboxyl protease activity involved in amyloid precursor protein degradation|down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|down regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|down-regulation of carboxyl protease activity involved in APP catabolic process|down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of aspartic protease activity involved in amyloid precursor protein degradation|down-regulation of aspartate protease activity involved in APP catabolism|down-regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|downregulation of carboxyl protease activity involved in APP catabolic process|down regulation of aspartate protease activity involved in amyloid precursor protein breakdown|down-regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|downregulation of aspartate protease activity involved in amyloid precursor protein catabolic process|inhibition of carboxyl protease activity involved in APP catabolic process|inhibition of aspartic protease activity involved in amyloid precursor protein breakdown|down regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|downregulation of aspartic endopeptidase activity involved in APP catabolism|down regulation of aspartic protease activity involved in amyloid precursor protein degradation|inhibition of carboxyl protease activity involved in amyloid precursor protein degradation|downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|negative regulation of aspartyl protease activity involved in APP catabolism|negative regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|downregulation of aspartic protease activity involved in amyloid precursor protein catabolism|downregulation of carboxyl protease activity involved in amyloid precursor protein catabolism|inhibition of aspartate protease activity involved in amyloid precursor protein catabolic process|down regulation of aspartate protease activity involved in APP catabolism|negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|down-regulation of carboxyl protease activity involved in amyloid precursor protein degradation|negative regulation of aspartate protease activity involved in APP catabolic process|inhibition of carboxyl protease activity involved in amyloid precursor protein catabolic process|inhibition of aspartic endopeptidase activity involved in amyloid precursor protein degradation|down regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|downregulation of carboxyl protease activity involved in APP catabolism|down-regulation of aspartic protease activity involved in APP catabolism|down regulation of aspartate protease activity involved in amyloid precursor protein catabolism|down regulation of aspartate protease activity involved in amyloid precursor protein degradation|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|down regulation of aspartyl protease activity involved in APP catabolic process|down regulation of aspartyl protease activity involved in amyloid precursor protein degradation|down regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|down regulation of aspartic protease activity involved in APP catabolism|down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|downregulation of carboxyl protease activity involved in amyloid precursor protein breakdown|negative regulation of aspartic endopeptidase activity involved in APP catabolic process|negative regulation of aspartic protease activity involved in amyloid precursor protein degradation|down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of aspartyl protease activity involved in amyloid precursor protein catabolism|down-regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|negative regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|inhibition of carboxyl protease activity involved in amyloid precursor protein breakdown|down regulation of aspartic-type endopeptidase activity involved in APP catabolism|down-regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|down-regulation of aspartate protease activity involved in amyloid precursor protein degradation|negative regulation of carboxyl protease activity involved in amyloid precursor protein catabolic process|down-regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|downregulation of aspartic protease activity involved in amyloid precursor protein breakdown|downregulation of aspartic protease activity involved in APP catabolism|inhibition of aspartic-type endopeptidase activity involved in APP catabolic process|negative regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|inhibition of aspartic protease activity involved in amyloid precursor protein catabolic process|down regulation of aspartate protease activity involved in APP catabolic process|downregulation of aspartic endopeptidase activity involved in APP catabolic process|down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of aspartate protease activity involved in amyloid precursor protein degradation|inhibition of carboxyl protease activity involved in APP catabolism|negative regulation of aspartic-type endopeptidase activity involved in APP catabolism|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|downregulation of aspartyl protease activity involved in APP catabolism|down regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|negative regulation of aspartate protease activity involved in amyloid precursor protein catabolism|down-regulation of aspartate protease activity involved in amyloid precursor protein catabolism|downregulation of aspartic protease activity involved in amyloid precursor protein catabolic process|down-regulation of aspartic-type endopeptidase activity involved in APP catabolism|inhibition of aspartate protease activity involved in APP catabolism|downregulation of aspartate protease activity involved in APP catabolism|inhibition of aspartyl protease activity involved in amyloid precursor protein breakdown|negative regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|negative regulation of aspartyl protease activity involved in APP catabolic process|down regulation of carboxyl protease activity involved in APP catabolism|downregulation of aspartate protease activity involved in amyloid precursor protein breakdown|inhibition of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of aspartyl protease activity involved in amyloid precursor protein catabolic process|inhibition of aspartyl protease activity involved in amyloid precursor protein degradation|inhibition of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|downregulation of aspartate protease activity involved in APP catabolic process|down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of aspartyl protease activity involved in APP catabolic process|down-regulation of aspartic endopeptidase activity involved in APP catabolic process|downregulation of aspartyl protease activity involved in amyloid precursor protein degradation|inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|inhibition of carboxyl protease activity involved in amyloid precursor protein catabolism|negative regulation of aspartic-type endopeptidase activity involved in APP catabolic process|negative regulation of aspartate protease activity involved in amyloid precursor protein breakdown|negative regulation of aspartyl protease activity involved in amyloid precursor protein breakdown|downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|inhibition of aspartic protease activity involved in amyloid precursor protein degradation|inhibition of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of carboxyl protease activity involved in APP catabolism|down-regulation of aspartic endopeptidase activity involved in amyloid precursor protein degradation|down regulation of aspartic endopeptidase activity involved in APP catabolism|negative regulation of aspartic protease activity involved in amyloid precursor protein breakdown|negative regulation of aspartic endopeptidase activity involved in APP catabolism|down regulation of aspartate protease activity involved in amyloid precursor protein catabolic process|downregulation of aspartic-type endopeptidase activity involved in APP catabolic process|negative regulation of carboxyl protease activity involved in amyloid precursor protein degradation|inhibition of aspartic endopeptidase activity involved in APP catabolic process|negative regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|negative regulation of carboxyl protease activity involved in APP catabolic process|inhibition of aspartyl protease activity involved in APP catabolic process|negative regulation of aspartic protease activity involved in amyloid precursor protein catabolism|down-regulation of carboxyl protease activity involved in amyloid precursor protein catabolism|down-regulation of aspartyl protease activity involved in APP catabolism|down regulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|down regulation of aspartyl protease activity involved in amyloid precursor protein catabolism|inhibition of aspartyl protease activity involved in amyloid precursor protein catabolism|down-regulation of aspartic protease activity involved in amyloid precursor protein degradation|downregulation of aspartyl protease activity involved in amyloid precursor protein breakdown|negative regulation of aspartate protease activity involved in amyloid precursor protein degradation|downregulation of aspartic endopeptidase activity involved in amyloid precursor protein catabolic process|down-regulation of aspartic protease activity involved in amyloid precursor protein breakdown|down regulation of aspartic protease activity involved in amyloid precursor protein catabolism|negative regulation of aspartate protease activity involved in APP catabolism|down-regulation of aspartic protease activity involved in amyloid precursor protein catabolism|down regulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|inhibition of aspartate protease activity involved in APP catabolic process|down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein degradation|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|downregulation of aspartic endopeptidase activity involved in amyloid precursor protein breakdown|downregulation of aspartyl protease activity involved in amyloid precursor protein catabolic process|down-regulation of aspartic-type endopeptidase activity involved in APP catabolic process|down regulation of aspartic protease activity involved in amyloid precursor protein breakdown|downregulation of aspartic-type endopeptidase activity involved in APP catabolism|downregulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolism|down regulation of aspartic-type endopeptidase activity involved in APP catabolic process|inhibition of aspartic protease activity involved in APP catabolic process|negative regulation of aspartic protease activity involved in APP catabolic process|down regulation of aspartic protease activity involved in amyloid precursor protein catabolic process|inhibition of aspartic protease activity involved in amyloid precursor protein catabolism|down-regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein breakdown|down regulation of carboxyl protease activity involved in amyloid precursor protein degradation|downregulation of aspartyl protease activity involved in APP catabolic process|down regulation of carboxyl protease activity involved in amyloid precursor protein breakdown|down-regulation of aspartate protease activity involved in APP catabolic process|down-regulation of aspartyl protease activity involved in amyloid precursor protein degradation|down-regulation of aspartic protease activity involved in APP catabolic process|down-regulation of aspartic endopeptidase activity involved in APP catabolism sjp 2014-05-06T09:07:11Z biological_process owl:Class
GO:1903188 biolink:NamedThing positive regulation of vitellogenesis Any process that activates or increases the frequency, rate or extent of vitellogenesis. got7fsn_ti up-regulation of yolk production|up-regulation of vitellogenesis|upregulation of yolk production|positive regulation of yolk production|up regulation of yolk production|upregulation of vitellogenesis|activation of vitellogenesis|up regulation of vitellogenesis|activation of yolk production mr 2014-07-14T19:28:12Z biological_process owl:Class
GO:0032433 biolink:NamedThing filopodium tip The end of a filopodium distal to the body of the cell. got7fsn_ti cellular_component owl:Class
GO:0015734 biolink:NamedThing taurine transport The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1905765 biolink:NamedThing negative regulation of protection from non-homologous end joining at telomere Any process that stops, prevents or reduces the frequency, rate or extent of protection from non-homologous end joining at telomere. got7fsn_ti downregulation of protection from NHEJ-mediated telomere fusion|downregulation of protection from non-homologous end joining at telomere|inhibition of protection from NHEJ-mediated telomere fusion|down regulation of protection from NHEJ-mediated telomere fusion|down-regulation of protection from non-homologous end joining at telomere|down-regulation of protection from NHEJ-mediated telomere fusion|inhibition of protection from non-homologous end joining at telomere|negative regulation of protection from NHEJ-mediated telomere fusion|down regulation of protection from non-homologous end joining at telomere nc 2016-12-20T11:28:30Z biological_process owl:Class
GO:0016346 biolink:NamedThing male meiotic chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis. got7fsn_ti male meiotic chromosome movement|chromosome movement towards spindle pole during male meiosis|male meiotic chromosome movement to spindle pole biological_process owl:Class
GO:2000788 biolink:NamedThing negative regulation of venous endothelial cell fate commitment Any process that stops, prevents or reduces the frequency, rate or extent of venous endothelial cell fate commitment. got7fsn_ti bf 2011-06-24T01:26:16Z biological_process owl:Class
GO:2000786 biolink:NamedThing positive regulation of autophagosome assembly Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly. got7fsn_ti positive regulation of autophagosome formation|positive regulation of autophagic vacuole assembly|positive regulation of autophagosome biosynthesis|positive regulation of PAS formation|positive regulation of autophagic vacuole formation rl 2011-06-24T11:19:12Z biological_process owl:Class
GO:0015807 biolink:NamedThing L-amino acid transport The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0005754 biolink:NamedThing mitochondrial proton-transporting ATP synthase, catalytic core The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase. got7fsn_ti cellular_component owl:Class
GO:1902775 biolink:NamedThing mitochondrial large ribosomal subunit assembly The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit. got7fsn_ti 39S ribosomal subunit, mitochondrial assembly|mitochondrial large ribosomal subunit formation|39S ribosomal subunit, mitochondrial formation mcc 2014-03-18T14:32:19Z biological_process owl:Class
GO:0061668 biolink:NamedThing mitochondrial ribosome assembly The aggregation, arrangement and bonding together of the mitochondrial ribosome and of its subunits. got7fsn_ti dph 2014-11-07T15:32:20Z biological_process owl:Class
GO:0045859 biolink:NamedThing regulation of protein kinase activity Any process that modulates the frequency, rate or extent of protein kinase activity. got7fsn_ti biological_process owl:Class
GO:0015213 biolink:NamedThing uridine transmembrane transporter activity Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. got7fsn_ti uracil/uridine permease activity molecular_function owl:Class
GO:0015862 biolink:NamedThing uridine transport The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0080122 biolink:NamedThing AMP transmembrane transporter activity Enables the transfer of AMP, adenosine monophosphate, from one side of a membrane to the other. got7fsn_ti adenosine monophosphate transmembrane transporter activity dhl 2009-04-28T04:05:39Z molecular_function owl:Class
GO:0080121 biolink:NamedThing AMP transport The directed movement of AMP, adenosine monophosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti adenosine monophosphate transport dhl 2009-04-28T04:01:37Z biological_process owl:Class
GO:0021624 biolink:NamedThing oculomotor nerve structural organization The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. got7fsn_ti oculomotor nerve structural organisation|CN III structural organization biological_process owl:Class
GO:0110163 biolink:NamedThing negative regulation of mitotic spindle elongation (spindle phase three) Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three). got7fsn_ti kmv 2019-08-12T15:29:43Z biological_process owl:Class
GO:1903023 biolink:NamedThing regulation of ascospore-type prospore membrane formation Any process that modulates the frequency, rate or extent of formation of an ascospore-type prospore membrane. got7fsn_ti regulation of FSM biosynthesis|regulation of ascospore-type prospore membrane assembly|regulation of forespore membrane formation|regulation of FSM assembly|regulation of forespore membrane biosynthesis|regulation of FSM formation al 2014-05-15T08:51:51Z biological_process owl:Class
GO:2000321 biolink:NamedThing positive regulation of T-helper 17 cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation. got7fsn_ti positive regulation of T-helper 17 cell development mah 2011-01-18T01:45:08Z biological_process owl:Class
GO:1902814 biolink:NamedThing positive regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry Any process that activates or increases the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry. got7fsn_ti upregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|positive regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|upregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|up regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|up-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|up regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|up-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|positive regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|up regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|activation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|activation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|up-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|activation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|upregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination mr 2014-03-26T21:18:56Z biological_process owl:Class
GO:0098854 biolink:NamedThing podocyte primary projection A cell projection originating from a renal glomerular podocyte and extending to the renal glomerular podocyte foot. got7fsn_ti glomerular visceral epithelial cell primary projection|podocyte major process|primary podocyte process cellular_component owl:Class
GO:0035409 biolink:NamedThing histone H3-Y41 phosphorylation The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone. got7fsn_ti bf 2010-03-24T10:13:13Z biological_process owl:Class
GO:0015209 biolink:NamedThing cytosine transmembrane transporter activity Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015856 biolink:NamedThing cytosine transport The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti cytosine transmembrane transport biological_process owl:Class
GO:0042218 biolink:NamedThing 1-aminocyclopropane-1-carboxylate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants. got7fsn_ti 1-aminocyclopropane-1-carboxylate biosynthesis|1-aminocyclopropane-1-carboxylate formation|1-aminocyclopropane-1-carboxylate anabolism|1-aminocyclopropane-1-carboxylate synthesis biological_process owl:Class
GO:1904429 biolink:NamedThing regulation of t-circle formation Any process that modulates the frequency, rate or extent of t-circle formation. got7fsn_ti regulation of telomeric circle formation nc 2015-07-03T15:15:45Z biological_process owl:Class
GO:0098903 biolink:NamedThing regulation of membrane repolarization during action potential Any process that modulates the rate, frequency or extent of membrane repolarization during an action potential. Membrane repolarization is the process in which membrane potential changes in the repolarizing direction, towards the resting potential. got7fsn_ti biological_process owl:Class
GO:0034517 biolink:NamedThing ribophagy The selective autophagy process in which cells degrade mature ribosomes under conditions of starvation. got7fsn_ti biological_process owl:Class
GO:0032790 biolink:NamedThing ribosome disassembly The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits. got7fsn_ti ribosome dissociation factor|ribosome recycling biological_process owl:Class
GO:0099567 biolink:NamedThing calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations. got7fsn_ti calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels|postsynaptic calcium ion buffering|regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering molecular_function owl:Class
GO:0006098 biolink:NamedThing pentose-phosphate shunt The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate). got7fsn_ti pentose phosphate pathway|pentose phosphate shunt|hexose monophosphate pathway|pentose-phosphate pathway KEGG_PATHWAY:00030|MetaCyc:PENTOSE-P-PWY|Reactome:R-HSA-71336|Wikipedia:Pentose_phosphate_pathway biological_process owl:Class
GO:1905606 biolink:NamedThing regulation of presynapse assembly Any process that modulates the frequency, rate or extent of presynapse assembly. got7fsn_ti regulation of presynapse biogenesis|regulation of presynaptic terminal assembly bc 2016-10-27T16:08:13Z biological_process owl:Class
GO:0002362 biolink:NamedThing CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell. got7fsn_ti CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment|CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment|CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment biological_process owl:Class
GO:0140195 biolink:NamedThing positive regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. got7fsn_ti pg 2018-02-15T19:13:11Z biological_process owl:Class
GO:0070289 biolink:NamedThing extracellular ferritin complex A ferritin complex located in the extracellular region. Extracellular ferritin complexes contain L (light) chains but few or no H (heavy) chains. got7fsn_ti serum ferritin complex cellular_component owl:Class
GO:0042944 biolink:NamedThing D-alanine transmembrane transporter activity Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid. got7fsn_ti D-alanine transporter activity molecular_function owl:Class
GO:0042941 biolink:NamedThing D-alanine transport The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0060392 biolink:NamedThing negative regulation of SMAD protein signal transduction Any process that decreases the rate, frequency or extent of the SMAD protein signaling pathway. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. got7fsn_ti negative regulation of SMAD protein import into nucleus|negative regulation of SMAD protein nuclear translocation biological_process owl:Class
GO:0051117 biolink:NamedThing ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. got7fsn_ti molecular_function owl:Class
GO:0033047 biolink:NamedThing regulation of mitotic sister chromatid segregation Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis. got7fsn_ti biological_process owl:Class
GO:1990880 biolink:NamedThing cellular detoxification of copper ion Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration. got7fsn_ti al 2015-10-21T14:34:40Z biological_process owl:Class
GO:0071280 biolink:NamedThing cellular response to copper ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus. got7fsn_ti cellular response to copper mah 2009-12-10T03:57:03Z biological_process owl:Class
CL:0000563 biolink:NamedThing got7fsn_ti owl:Class
CL:0000106 biolink:NamedThing got7fsn_ti owl:Class
GO:0061222 biolink:NamedThing mesonephric mesenchymal cell proliferation involved in mesonephros development The multiplication or reproduction of cells, resulting in the expansion of a mesonephric mesenchymal cell population. got7fsn_ti dph 2010-08-19T01:20:14Z biological_process owl:Class
GO:0021914 biolink:NamedThing negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord. got7fsn_ti negative regulation of hh signaling pathway involved in ventral spinal cord patterning|downregulation of smoothened signaling pathway in ventral spinal cord patterning|inhibition of smoothened signaling pathway in ventral spinal cord patterning|negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning|negative regulation of smoothened signalling pathway in ventral spinal cord patterning|down-regulation of smoothened signaling pathway in ventral spinal cord patterning|down regulation of smoothened signaling pathway in ventral spinal cord patterning biological_process owl:Class
GO:1903980 biolink:NamedThing positive regulation of microglial cell activation Any process that activates or increases the frequency, rate or extent of microglial cell activation. got7fsn_ti activation of microglial cell activation|up regulation of microglial cell activation|upregulation of microglial cell activation|up-regulation of microglial cell activation nc 2015-03-02T15:17:44Z biological_process owl:Class
GO:0020022 biolink:NamedThing acidocalcisome An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations. got7fsn_ti metachromatic granule|volutin granule|polyphosphate vacuole cellular_component owl:Class
GO:0050652 biolink:NamedThing dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate. got7fsn_ti chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthesis|chondroitin sulfate B proteoglycan chain elongation|chondroitin sulfate B proteoglycan biosynthesis, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan formation, polysaccharide chain formation|dermatan sulfate proteoglycan synthesis, polysaccharide chain synthesis|dermatan sulfate proteoglycan anabolism, polysaccharide chain anabolism|dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process|dermatan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis|dermatan sulfate proteoglycan chain elongation|dermatan sulfate proteoglycan formation, polysaccharide chain biosynthesis biological_process owl:Class
GO:0038197 biolink:NamedThing type I interferon receptor complex A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). got7fsn_ti interferon-alpha/beta receptor complex bf 2013-11-27T14:53:50Z cellular_component owl:Class
GO:0051895 biolink:NamedThing negative regulation of focal adhesion assembly Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. got7fsn_ti down regulation of focal adhesion formation|down-regulation of focal adhesion formation|inhibition of focal adhesion formation|downregulation of focal adhesion formation biological_process owl:Class
GO:0019246 biolink:NamedThing L(+)-lactate biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate. got7fsn_ti L(+)-lactate formation from pyruvate|L(+)-lactate synthesis from pyruvate|S-lactate biosynthetic process from pyruvate|L(+)-lactate anabolism from pyruvate MetaCyc:PWY-5481 biological_process owl:Class
GO:0048502 biolink:NamedThing ABC-type thiamine transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine(out) = ADP + H(+) + phosphate + thiamine(in). got7fsn_ti thiamin pyrophosphate transporting ATPase activity|ATPase-coupled thiamine transmembrane transporter activity|ATP-dependent thiamine transmembrane transporter activity|thiamine ABC transporter|thiamine-transporting ATPase activity|thiamin-transporting ATPase activity|thiamin pyrophosphate porter activity|TPP transporting ATPase activity|thiamine pyrophosphate-transporting ATPase activity|thiamin pyrophosphate ABC transporter GO:0015619 TC:3.A.1.19.1|RHEA:29811|EC:7.6.2.15 molecular_function owl:Class
GO:0071934 biolink:NamedThing thiamine transmembrane transport The process in which thiamine is transported across a membrane. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. got7fsn_ti thiamine membrane transport|thiamin transmembrane transport|vitamin B1 transmembrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-09-29T02:59:39Z biological_process owl:Class
GO:0070802 biolink:NamedThing regulation of metula development Any process that modulates the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip. got7fsn_ti mah 2009-07-08T04:14:34Z biological_process owl:Class
GO:0150011 biolink:NamedThing regulation of neuron projection arborization Any process that modulates the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches. got7fsn_ti regulation of neuron projection branching|regulation of neurite arborization|regulation of neurite branching bc 2017-12-13T16:32:34Z biological_process owl:Class
UBERON:0006562 biolink:NamedThing got7fsn_ti owl:Class
GO:0003312 biolink:NamedThing pancreatic PP cell differentiation The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide. got7fsn_ti pancreatic polypeptide-producing cell differentiation dph 2009-10-26T09:32:32Z biological_process owl:Class
GO:0097165 biolink:NamedThing nuclear stress granule A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. got7fsn_ti pr 2011-09-28T07:49:55Z cellular_component owl:Class
GO:0000809 biolink:NamedThing cytoplasmic origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm. got7fsn_ti prokaryotic ORC|cytoplasmic ORC cellular_component owl:Class
GO:2000873 biolink:NamedThing regulation of histone H4 acetylation involved in response to DNA damage stimulus Any process that modulates the frequency, rate or extent of histone H4 acetylation involved in response to DNA damage stimulus. got7fsn_ti regulation of histone H4 acetylation involved in cellular response to DNA damage stimulus|regulation of histone H4 acetylation involved in cellular DNA damage response|regulation of histone H4 acetylation involved in response to DNA damage|regulation of histone H4 acetylation involved in response to genotoxic stress|regulation of histone H4 acetylation involved in DNA damage response mah 2011-07-26T10:05:23Z biological_process owl:Class
GO:1905140 biolink:NamedThing regulation of apical ectodermal ridge formation Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation. got7fsn_ti regulation of crista ectodermalis apicalis formation|regulation of AER formation|regulation of apical epidermal ridge formation dph 2016-04-13T12:16:40Z biological_process owl:Class
GO:1905904 biolink:NamedThing positive regulation of mesoderm formation Any process that activates or increases the frequency, rate or extent of mesoderm formation. got7fsn_ti up regulation of mesoderm formation|upregulation of mesoderm formation|up-regulation of mesoderm formation|activation of mesoderm formation rph 2017-02-03T12:28:38Z biological_process owl:Class
GO:0001178 biolink:NamedThing regulation of transcriptional start site selection at RNA polymerase II promoter Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript. got7fsn_ti regulation of transcriptional start site selection at RNA polymerase II promoter|regulation of transcription start site selection at RNA polymerase II promoter krc 2011-06-20T02:06:00Z biological_process owl:Class
GO:1904943 biolink:NamedThing negative regulation of cardiac ventricle formation Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation. got7fsn_ti down regulation of cardiac ventricle formation|down-regulation of cardiac ventricle formation|inhibition of cardiac ventricle formation|downregulation of cardiac ventricle formation bc 2016-02-02T16:37:24Z biological_process owl:Class
GO:1904514 biolink:NamedThing positive regulation of initiation of premeiotic DNA replication Any process that activates or increases the frequency, rate or extent of initiation of premeiotic DNA replication. got7fsn_ti positive regulation of initiation of meiotic DNA synthesis|up regulation of initiation of premeiotic DNA synthesis|up regulation of meiotic DNA replication initiation|upregulation of initiation of meiotic DNA synthesis|upregulation of initiation of premeiotic DNA synthesis|up-regulation of premeiotic DNA replication initiation|up-regulation of initiation of premeiotic DNA replication|positive regulation of premeiotic DNA replication initiation|up regulation of initiation of meiotic DNA synthesis|upregulation of premeiotic DNA replication initiation|activation of initiation of premeiotic DNA synthesis|activation of initiation of premeiotic DNA replication|upregulation of initiation of premeiotic DNA replication|up-regulation of meiotic DNA replication initiation|positive regulation of meiotic DNA replication initiation|up regulation of initiation of premeiotic DNA replication|activation of initiation of meiotic DNA synthesis|positive regulation of initiation of premeiotic DNA synthesis|up regulation of premeiotic DNA replication initiation|up-regulation of initiation of meiotic DNA synthesis|activation of premeiotic DNA replication initiation|activation of meiotic DNA replication initiation|up-regulation of initiation of premeiotic DNA synthesis|upregulation of meiotic DNA replication initiation mah 2015-07-28T12:59:29Z biological_process owl:Class
GO:0075308 biolink:NamedThing negative regulation of conidium formation Any process that stops, prevents, or reduces the frequency, rate or extent of conidium formation, a process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus. got7fsn_ti biological_process owl:Class
GO:0001646 biolink:NamedThing cAMP receptor activity Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. got7fsn_ti class E G protein coupled receptor|cyclic AMP receptor activity|class E GPCR|3',5'-cAMP receptor activity|3',5' cAMP receptor activity|class E G-protein coupled receptor|adenosine 3',5'-cyclophosphate receptor activity GO:0001644 molecular_function owl:Class
GO:0005964 biolink:NamedThing phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. got7fsn_ti cellular_component owl:Class
GO:0070610 biolink:NamedThing regulation of fungal-type cell wall (1->3)-alpha-glucan biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-alpha glucans, compounds composed of glucose residues linked by (1->3)-alpha-D-glucosidic bonds, found in fungal-type cell walls, including those of ascospores. got7fsn_ti regulation of fungal-type cell wall 1,3-alpha-glucan formation|regulation of fungal type cell wall 1,3-alpha-glucan biosynthetic process|regulation of fungal-type cell wall alpha-1,3-glucan biosynthetic process|regulation of fungal-type cell wall 1,3-alpha-glucan biosynthesis|regulation of fungal-type cell wall alpha-1,3-glucan biosynthesis|regulation of fungal-type cell wall alpha-1,3-glucan formation|regulation of fungal-type cell wall 1,3-alpha-glucan synthesis|regulation of fungal-type cell wall 1,3-alpha-glucan anabolism|regulation of fungal-type cell wall alpha-1,3-glucan synthesis|regulation of fungal-type cell wall alpha-1,3-glucan anabolism mah 2009-04-29T01:32:19Z biological_process owl:Class
GO:0071917 biolink:NamedThing triose-phosphate transmembrane transporter activity Enables the transfer of a triose phosphate from one side of a membrane to the other. got7fsn_ti mah 2010-09-24T10:35:26Z molecular_function owl:Class
GO:0035436 biolink:NamedThing triose phosphate transmembrane transport The process in which triose phosphate (glyceraldehyde 3-phosphate) is transported across a membrane. Glyceraldehyde 3-phosphate is any organic three carbon compound phosphate ester. got7fsn_ti triose phosphate membrane transport|triose phosphate transmembrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-08T02:54:07Z biological_process owl:Class
GO:0015767 biolink:NamedThing lactose transport The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals. got7fsn_ti biological_process owl:Class
GO:0060331 biolink:NamedThing negative regulation of response to interferon-gamma Any process that decreases the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. got7fsn_ti negative regulation of response to immune interferon|negative regulation of response to type II interferon|negative regulation of response to gamma-interferon|negative regulation of response to type II IFN biological_process owl:Class
GO:0036054 biolink:NamedThing protein-malonyllysine demalonylase activity Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide. got7fsn_ti protein lysine demalonylation activity|peptidyl-malonyllysine demalonylase activity|protein malonyl lysine demalonylation activity bf 2011-12-12T01:29:21Z molecular_function owl:Class
GO:0045214 biolink:NamedThing sarcomere organization The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs. got7fsn_ti sarcomere organisation|sarcomere alignment GO:0006938 biological_process owl:Class
GO:0032278 biolink:NamedThing positive regulation of gonadotropin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin. got7fsn_ti positive regulation of gonadotrophin secretion|upregulation of gonadotropin secretion|up-regulation of gonadotropin secretion|activation of gonadotropin secretion|stimulation of gonadotropin secretion|up regulation of gonadotropin secretion biological_process owl:Class
GO:0021887 biolink:NamedThing hypothalamus gonadotrophin-releasing hormone neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone. got7fsn_ti hypothalamus gonadotropin-releasing hormone neuron fate commitment biological_process owl:Class
GO:1904031 biolink:NamedThing positive regulation of cyclin-dependent protein kinase activity Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein kinase activity. got7fsn_ti activation of cyclin-dependent protein kinase activity|up-regulation of cyclin-dependent protein kinase activity|upregulation of cyclin-dependent protein kinase activity|up regulation of cyclin-dependent protein kinase activity als 2015-03-13T15:43:50Z biological_process owl:Class
GO:0030177 biolink:NamedThing positive regulation of Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of Wnt signal transduction. got7fsn_ti up regulation of frizzled signaling pathway|positive regulation of Wnt-activated signaling pathway|positive regulation of Wnt receptor signaling pathway|activation of Wnt receptor signaling pathway|up-regulation of Wnt receptor signaling pathway|positive regulation of Wnt receptor signalling pathway|upregulation of frizzled signaling pathway|stimulation of frizzled signaling pathway|activation of frizzled signaling pathway|up regulation of Wnt receptor signaling pathway|up-regulation of frizzled signaling pathway|positive regulation of frizzled signalling pathway|positive regulation of frizzled signaling pathway|upregulation of Wnt receptor signaling pathway|stimulation of Wnt receptor signaling pathway GO:0045811 biological_process owl:Class
GO:0015414 biolink:NamedThing ABC-type nitrate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in). got7fsn_ti nitrate transporting ATPase activity|ATPase-coupled nitrate transmembrane transporter activity|nitrate transmembrane-transporting ATPase activity|nitrate ABC transporter|nitrate-transporting ATPase activity RHEA:13181|MetaCyc:3.6.3.26-RXN|EC:7.3.2.4 molecular_function owl:Class
GO:0003381 biolink:NamedThing epithelial cell morphogenesis involved in gastrulation The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation. got7fsn_ti dph 2009-12-09T07:18:53Z biological_process owl:Class
GO:2000102 biolink:NamedThing negative regulation of mammary stem cell proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation. got7fsn_ti dph 2010-09-14T06:10:34Z biological_process owl:Class
GO:0015158 biolink:NamedThing raffinose transmembrane transporter activity Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. got7fsn_ti raffinose permease molecular_function owl:Class
GO:0015773 biolink:NamedThing raffinose transport The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol. got7fsn_ti biological_process owl:Class
GO:0003326 biolink:NamedThing pancreatic A cell fate commitment The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon. got7fsn_ti dph 2009-11-02T08:29:00Z biological_process owl:Class
GO:0045625 biolink:NamedThing regulation of T-helper 1 cell differentiation Any process that modulates the frequency, rate or extent of T-helper 1 cell differentiation. got7fsn_ti regulation of T-helper 1 cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0031928 biolink:NamedThing pyridoxine transmembrane transporter activity Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. got7fsn_ti pyridoxine transporter activity molecular_function owl:Class
GO:1903092 biolink:NamedThing pyridoxine transmembrane transport The process in which pyridoxine is transported across a membrane. got7fsn_ti al 2014-06-03T10:41:26Z biological_process owl:Class
GO:0014833 biolink:NamedThing skeletal muscle satellite stem cell asymmetric division The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool. got7fsn_ti satellite cell asymmetric division biological_process owl:Class
CL:0000362 biolink:NamedThing got7fsn_ti owl:Class
GO:0048083 biolink:NamedThing negative regulation of adult chitin-containing cuticle pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of the adult pattern of pigmentation in the cuticle of an organism. got7fsn_ti down-regulation of adult chitin-containing cuticle pigmentation|inhibition of adult chitin-containing cuticle pigmentation|downregulation of adult chitin-containing cuticle pigmentation|down regulation of adult chitin-containing cuticle pigmentation biological_process owl:Class
GO:0007318 biolink:NamedThing pole plasm protein localization Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster. got7fsn_ti pole plasm protein localisation|establishment and maintenance of pole plasm protein localization|oocyte pole plasm protein localization GO:0048115 biological_process owl:Class
GO:0035744 biolink:NamedThing T-helper 1 cell cytokine production Any process that contributes to cytokine production by a T-helper 1 cell. got7fsn_ti Th1 cell cytokine production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. bf 2011-03-17T02:22:54Z biological_process owl:Class
GO:0039631 biolink:NamedThing DNA translocase activity involved in viral DNA genome packaging Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid. got7fsn_ti viral DNA packaging motor activity|viral DNA packaging activity bf 2012-08-07T11:17:07Z molecular_function owl:Class
GO:0015212 biolink:NamedThing cytidine transmembrane transporter activity Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015861 biolink:NamedThing cytidine transport The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0032127 biolink:NamedThing dense core granule membrane The lipid bilayer surrounding a dense core granule. got7fsn_ti dense core vesicle membrane cellular_component owl:Class
GO:0034506 biolink:NamedThing chromosome, centromeric core domain The innermost portion of the centromeric region of a chromosome, encompassing the core region of a chromosome centromere and the proteins that bind to it. got7fsn_ti chromosome, centromeric core region|chromosome, centric core region cellular_component owl:Class
GO:0000319 biolink:NamedThing sulfite transmembrane transporter activity Enables the transfer of sulfite ions from one side of a membrane to the other. got7fsn_ti sulphite transporter activity molecular_function owl:Class
GO:0000316 biolink:NamedThing sulfite transport The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti sulphite transport biological_process owl:Class
GO:0060924 biolink:NamedThing atrial cardiac muscle cell fate commitment The commitment of cells to atrial cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells of the atrium. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. got7fsn_ti atrial cardiomyocyte cell fate commitment|atrial heart muscle cell fate commitment dph 2009-09-29T11:46:10Z biological_process owl:Class
GO:1903914 biolink:NamedThing negative regulation of fusion of virus membrane with host plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of fusion of virus membrane with host plasma membrane. got7fsn_ti down-regulation of fusion of virus membrane with host plasma membrane|inhibition of viral envelope fusion with host cell membrane|negative regulation of viral-cell fusion molecule activity|down-regulation of viral envelope fusion with host cell membrane|down-regulation of viral-cell fusion molecule activity|downregulation of viral entry into host cell via membrane fusion with the plasma membrane|inhibition of fusion of virus membrane with host plasma membrane|inhibition of viral-cell fusion molecule activity|inhibition of viral entry into host cell via membrane fusion with the plasma membrane|negative regulation of viral penetration via membrane fusion|negative regulation of viral envelope fusion with host membrane|down regulation of viral envelope fusion with host cell membrane|down regulation of viral penetration via membrane fusion|down-regulation of viral entry into host cell via membrane fusion with the plasma membrane|inhibition of viral envelope fusion with host plasma membrane|downregulation of viral envelope fusion with host cell membrane|downregulation of viral envelope fusion with host membrane|negative regulation of viral entry into host cell via membrane fusion with the plasma membrane|down regulation of viral entry into host cell via membrane fusion with the plasma membrane|down-regulation of viral envelope fusion with host membrane|downregulation of viral penetration via membrane fusion|negative regulation of viral envelope fusion with host cell membrane|negative regulation of viral envelope fusion with host plasma membrane|down regulation of viral envelope fusion with host plasma membrane|down-regulation of viral penetration via membrane fusion|down-regulation of viral envelope fusion with host plasma membrane|inhibition of viral penetration via membrane fusion|inhibition of viral envelope fusion with host membrane|downregulation of viral-cell fusion molecule activity|downregulation of viral envelope fusion with host plasma membrane|down regulation of fusion of virus membrane with host plasma membrane|down regulation of viral-cell fusion molecule activity|downregulation of fusion of virus membrane with host plasma membrane|down regulation of viral envelope fusion with host membrane als 2015-02-09T11:13:32Z biological_process owl:Class
GO:0000957 biolink:NamedThing mitochondrial RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion. got7fsn_ti biological_process owl:Class
GO:1905208 biolink:NamedThing negative regulation of cardiocyte differentiation Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation. got7fsn_ti down regulation of heart cell differentiation|downregulation of cardiac cell differentiation|down regulation of cardiocyte differentiation|down regulation of cardiac cell differentiation|downregulation of cardiocyte differentiation|down-regulation of heart cell differentiation|negative regulation of cardiac cell differentiation|inhibition of cardiac cell differentiation|inhibition of cardiocyte differentiation|down-regulation of cardiac cell differentiation|inhibition of heart cell differentiation|downregulation of heart cell differentiation|negative regulation of heart cell differentiation|down-regulation of cardiocyte differentiation bc 2016-06-02T07:20:09Z biological_process owl:Class
GO:0098897 biolink:NamedThing spine apparatus membrane The lipid bilayer surrounding the spine apparatus. got7fsn_ti cellular_component owl:Class
GO:1905753 biolink:NamedThing positive regulation of argininosuccinate synthase activity Any process that activates or increases the frequency, rate or extent of argininosuccinate synthase activity. got7fsn_ti activation of L-citrulline:L-aspartate ligase (AMP-forming)|positive regulation of arginine succinate synthetase activity|activation of arginosuccinate synthetase activity|positive regulation of argininosuccinate synthetase activity|upregulation of argininosuccinic acid synthetase activity|upregulation of citrulline--aspartate ligase activity|upregulation of arginine succinate synthetase activity|up-regulation of citrulline--aspartate ligase activity|upregulation of argininosuccinate synthase activity|activation of argininosuccinate synthase activity|up regulation of argininosuccinate synthetase activity|activation of argininosuccinate synthetase activity|activation of arginine succinate synthetase activity|positive regulation of citrulline--aspartate ligase activity|positive regulation of L-citrulline:L-aspartate ligase (AMP-forming)|up regulation of citrulline--aspartate ligase activity|up-regulation of L-citrulline:L-aspartate ligase (AMP-forming)|up-regulation of argininosuccinic acid synthetase activity|positive regulation of arginosuccinate synthetase activity|up-regulation of argininosuccinate synthetase activity|upregulation of arginosuccinate synthetase activity|activation of argininosuccinic acid synthetase activity|upregulation of L-citrulline:L-aspartate ligase (AMP-forming)|up regulation of arginine succinate synthetase activity|up regulation of argininosuccinic acid synthetase activity|up regulation of arginosuccinate synthetase activity|up-regulation of arginine succinate synthetase activity|up regulation of L-citrulline:L-aspartate ligase (AMP-forming)|up-regulation of arginosuccinate synthetase activity|up regulation of argininosuccinate synthase activity|activation of citrulline--aspartate ligase activity|up-regulation of argininosuccinate synthase activity|upregulation of argininosuccinate synthetase activity|positive regulation of argininosuccinic acid synthetase activity dos 2016-12-12T11:44:09Z biological_process owl:Class
GO:0015439 biolink:NamedThing ABC-type heme transporter activity Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out). got7fsn_ti haem-transporting ATPase activity|protoheme IX ABC transporter activity|ATP-dependent heme transmembrane transporter activity|ATPase-coupled heme transporter activity|ATPase-coupled heme transmembrane transporter activity|heme ABC transporter|heme-transporting ATPase activity GO:0103115 MetaCyc:3.6.3.41-RXN|MetaCyc:TRANS-RXN0-162|Reactome:R-HSA-5683355|Reactome:R-HSA-382560|EC:7.6.2.5|RHEA:19261|Reactome:R-HSA-1369065|Reactome:R-HSA-917979 molecular_function owl:Class
GO:0035351 biolink:NamedThing heme transmembrane transport The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti heme membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-03-04T03:45:46Z biological_process owl:Class
OBO:OBA_0000143 biolink:NamedThing got7fsn_ti owl:Class
GO:0106163 biolink:NamedThing regulation of exonucleolytic catabolism of deadenylated mRNA Any process that modulates the frequency, rate or extent of exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay. got7fsn_ti hjd 2019-01-15T15:33:08Z biological_process owl:Class
GO:0043321 biolink:NamedThing regulation of natural killer cell degranulation Any process that modulates the frequency, rate, or extent of natural killer cell degranulation. got7fsn_ti regulation of natural killer cell granule exocytosis|regulation of NK cell degranulation|regulation of NK cell granule exocytosis biological_process owl:Class
GO:0042887 biolink:NamedThing amide transmembrane transporter activity Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. got7fsn_ti amine/amide/polyamine channel activity molecular_function owl:Class
GO:1903050 biolink:NamedThing regulation of proteolysis involved in cellular protein catabolic process Any process that modulates the frequency, rate or extent of proteolysis involved in cellular protein catabolic process. got7fsn_ti regulation of peptidolysis during cellular protein catabolism|regulation of proteolysis during cellular protein catabolic process|regulation of peptidolysis during cellular protein catabolic process|regulation of proteolysis during cellular protein catabolism|regulation of peptidolysis involved in cellular protein catabolism|regulation of peptidolysis involved in cellular protein catabolic process overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP) rl 2014-05-22T18:00:45Z biological_process owl:Class
GO:0051797 biolink:NamedThing regulation of hair follicle development Any process that modulates the frequency, rate or extent of hair follicle development. got7fsn_ti biological_process owl:Class
UBERON:0001016 biolink:NamedThing got7fsn_ti owl:Class
GO:0000480 biolink:NamedThing endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. got7fsn_ti endonucleolytic cleavage at A-prime|endonucleolytic cleavage at A0 biological_process owl:Class
GO:0033008 biolink:NamedThing positive regulation of mast cell activation involved in immune response Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response. got7fsn_ti positive regulation of mast cell activation during immune response biological_process owl:Class
GO:0006182 biolink:NamedThing cGMP biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. got7fsn_ti cGMP formation|cGMP biosynthesis|cGMP synthesis|cGMP anabolism biological_process owl:Class
GO:0099572 biolink:NamedThing postsynaptic specialization A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. got7fsn_ti cellular_component owl:Class
GO:0005260 biolink:NamedThing intracellularly ATP-gated chloride channel activity Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. got7fsn_ti ATP-binding and phosphorylation-dependent chloride channel activity|ATP phosphohydrolase (channel-conductance-controlling)|cystic-fibrosis membrane-conductance-regulating protein activity|channel-conductance-controlling ATPase activity|cystic fibrosis transmembrane conductance regulator https://github.com/geneontology/go-ontology/issues/14402 GO:0005224 MetaCyc:3.6.3.49-RXN|EC:5.6.1.6 molecular_function owl:Class
GO:0042664 biolink:NamedThing negative regulation of endodermal cell fate specification Any process that restricts, stops or prevents a cell from specifying into an endoderm cell. got7fsn_ti inhibition of endodermal cell fate specification|down regulation of endodermal cell fate specification|down-regulation of endodermal cell fate specification|suppression of endodermal cell fate|suppression of endoderm cell fate|downregulation of endodermal cell fate specification|negative regulation of endoderm cell fate specification biological_process owl:Class
GO:1904595 biolink:NamedThing positive regulation of termination of RNA polymerase II transcription Any process that activates or increases the frequency, rate or extent of termination of RNA polymerase II transcription. got7fsn_ti upregulation of RNA 3'-end formation by RNA polymerase II|positive regulation of RNA 3'-end formation by RNA polymerase II|up regulation of transcription termination from Pol II promoter|positive regulation of transcription termination from Pol II promoter|activation of RNA polymerase II transcription termination|up regulation of transcription termination from RNA polymerase II promoter|up regulation of termination of RNA polymerase II transcription|upregulation of termination of RNA polymerase II transcription|positive regulation of RNA polymerase II transcription termination|up regulation of RNA polymerase II transcription termination|up-regulation of transcription termination from Pol II promoter|up-regulation of RNA polymerase II transcription termination factor activity|upregulation of RNA polymerase II transcription termination|activation of RNA 3'-end formation by RNA polymerase II|upregulation of transcription termination from Pol II promoter|activation of termination of RNA polymerase II transcription|up regulation of RNA 3'-end formation by RNA polymerase II|up-regulation of termination of RNA polymerase II transcription|up-regulation of RNA polymerase II transcription termination|activation of transcription termination from Pol II promoter|upregulation of RNA polymerase II transcription termination factor activity|positive regulation of transcription termination from RNA polymerase II promoter|up-regulation of RNA 3'-end formation by RNA polymerase II|positive regulation of RNA polymerase II transcription termination factor activity|upregulation of transcription termination from RNA polymerase II promoter|activation of RNA polymerase II transcription termination factor activity|up regulation of RNA polymerase II transcription termination factor activity|activation of transcription termination from RNA polymerase II promoter|up-regulation of transcription termination from RNA polymerase II promoter al 2015-08-25T08:56:14Z biological_process owl:Class
GO:0050542 biolink:NamedThing icosanoid binding Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids. got7fsn_ti eicosanoid binding molecular_function owl:Class
GO:0036224 biolink:NamedThing pairing center A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment. got7fsn_ti homolog recognition region bf 2012-05-09T02:28:53Z cellular_component owl:Class
GO:0060463 biolink:NamedThing lung lobe morphogenesis The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung. got7fsn_ti biological_process owl:Class
GO:1903048 biolink:NamedThing regulation of acetylcholine-gated cation channel activity Any process that modulates the frequency, rate or extent of acetylcholine-gated cation channel activity. got7fsn_ti bf 2014-05-22T14:46:53Z biological_process owl:Class
GO:0043304 biolink:NamedThing regulation of mast cell degranulation Any process that modulates the frequency, rate, or extent of mast cell degranulation. got7fsn_ti regulation of mast cell granule exocytosis biological_process owl:Class
GO:0060137 biolink:NamedThing maternal process involved in parturition A reproductive process occurring in the mother that results in birth. got7fsn_ti biological_process owl:Class
GO:0015159 biolink:NamedThing polysaccharide transmembrane transporter activity Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. got7fsn_ti molecular_function owl:Class
GO:0015141 biolink:NamedThing succinate transmembrane transporter activity Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other. got7fsn_ti dicarboxylate (succinate/fumarate/malate) antiporter activity molecular_function owl:Class
GO:0071422 biolink:NamedThing succinate transmembrane transport The process in which succinate is transported across a membrane. got7fsn_ti succinate membrane transport|transmembrane succinate transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2009-12-15T03:29:44Z biological_process owl:Class
GO:0015087 biolink:NamedThing cobalt ion transmembrane transporter activity Enables the transfer of cobalt (Co) ions from one side of a membrane to the other. got7fsn_ti cobalt, zinc uptake permease activity|zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity RHEA:28578 molecular_function owl:Class
GO:2000392 biolink:NamedThing regulation of lamellipodium morphogenesis Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis. got7fsn_ti regulation of lamellipodium organization mah 2011-02-22T11:18:58Z biological_process owl:Class
GO:0031134 biolink:NamedThing sister chromatid biorientation The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles. got7fsn_ti sister kinetochore biorientation|chromosome biorientation biological_process owl:Class
GO:1902957 biolink:NamedThing negative regulation of mitochondrial electron transport, NADH to ubiquinone Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone. got7fsn_ti down-regulation of mitochondrial electron transport, NADH to ubiquinone|negative regulation of oxidative phosphorylation, NADH to ubiquinone|inhibition of oxidative phosphorylation, NADH to ubiquinone|inhibition of complex I (NADH to ubiquinone)|inhibition of mitochondrial electron transport, NADH to ubiquinone|down regulation of mitochondrial electron transport, NADH to ubiquinone|downregulation of complex I (NADH to ubiquinone)|down-regulation of oxidative phosphorylation, NADH to ubiquinone|downregulation of oxidative phosphorylation, NADH to ubiquinone|down regulation of oxidative phosphorylation, NADH to ubiquinone|negative regulation of complex I (NADH to ubiquinone)|downregulation of mitochondrial electron transport, NADH to ubiquinone|down-regulation of complex I (NADH to ubiquinone)|down regulation of complex I (NADH to ubiquinone) dph 2014-05-02T15:30:18Z biological_process owl:Class
GO:0033042 biolink:NamedThing umami taste receptor activity Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates. got7fsn_ti molecular_function owl:Class
GO:0046535 biolink:NamedThing detection of chemical stimulus involved in sensory perception of umami taste The series of events required for a umami taste stimulus to be received and converted to a molecular signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. got7fsn_ti umami taste detection|perception of umami taste, detection of chemical stimulus|sensory transduction of chemical stimulus during perception of umami taste|sensory detection of umami taste|sensory transduction of umami taste|sensory detection of chemical stimulus during perception of umami taste|perception of umami taste, sensory transduction of chemical stimulus biological_process owl:Class
GO:0002899 biolink:NamedThing negative regulation of central B cell deletion Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion. got7fsn_ti down-regulation of central B cell deletion|inhibition of central B cell deletion|downregulation of central B cell deletion|down regulation of central B cell deletion biological_process owl:Class
GO:0035745 biolink:NamedThing T-helper 2 cell cytokine production Any process that contributes to cytokine production by a T-helper 2 cell. got7fsn_ti Th2 cell cytokine production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. bf 2011-03-17T02:23:32Z biological_process owl:Class
GO:0048902 biolink:NamedThing anterior lateral line neuromast deposition The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line. got7fsn_ti biological_process owl:Class
GO:0072206 biolink:NamedThing metanephric juxtaglomerular apparatus development The process whose specific outcome is the progression of the juxtaglomerular apparatus in the metanephros over time, from its formation to the mature structure. The juxtaglomerular apparatus is an anatomical structure which consists of juxtaglomerular cells, extraglomerular mesangial cells and the macula densa. The juxtaglomerular apparatus lies adjacent to the glomerulus and regulates kidney function by maintaining the blood flow to the kidney and the filtration rate. got7fsn_ti mah 2010-03-18T11:17:47Z biological_process owl:Class
GO:2000004 biolink:NamedThing regulation of metanephric S-shaped body morphogenesis Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis. got7fsn_ti jl 2010-07-30T02:14:33Z biological_process owl:Class
GO:2000651 biolink:NamedThing positive regulation of sodium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity. got7fsn_ti positive regulation of sodium transporter activity yaf 2011-04-28T08:43:00Z biological_process owl:Class
GO:0071085 biolink:NamedThing alphaIIb-beta3 integrin-CD9 complex A protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface protein CD9. got7fsn_ti ITGA2b-ITGB3-CD9 complex mah 2009-11-06T04:44:52Z cellular_component owl:Class
GO:0015749 biolink:NamedThing monosaccharide transmembrane transport The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. got7fsn_ti monosaccharide transport vw 2017-02-19T10:41:27Z GO:1905950 biological_process owl:Class
GO:0002834 biolink:NamedThing regulation of response to tumor cell Any process that modulates the frequency, rate, or extent of a response to tumor cell. got7fsn_ti regulation of response to tumour cell biological_process owl:Class
GO:0030173 biolink:NamedThing integral component of Golgi membrane The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti Golgi integral membrane protein|integral to Golgi membrane cellular_component owl:Class
GO:0015229 biolink:NamedThing L-ascorbic acid transmembrane transporter activity Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species. got7fsn_ti L-ascorbate transporter activity|vitamin C transporter activity Reactome:R-HSA-198870 molecular_function owl:Class
GO:1904254 biolink:NamedThing regulation of iron ion transmembrane transporter activity Any process that modulates the frequency, rate or extent of an iron transmembrane transporter activity. got7fsn_ti regulation of iron cation channel activity|regulation of iron-specific channel activity|regulation of iron channel activity kom 2015-05-20T14:05:00Z biological_process owl:Class
CL:0002063 biolink:NamedThing got7fsn_ti owl:Class
GO:0060743 biolink:NamedThing epithelial cell maturation involved in prostate gland development The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface. got7fsn_ti prostate gland epithelial cell development dph 2009-06-16T09:34:42Z biological_process owl:Class
GO:0048814 biolink:NamedThing regulation of dendrite morphogenesis Any process that modulates the frequency, rate or extent of dendrite morphogenesis. got7fsn_ti biological_process owl:Class
GO:0043305 biolink:NamedThing negative regulation of mast cell degranulation Any process that stops, prevents, or reduces the rate of mast cell degranulation. got7fsn_ti down regulation of mast cell degranulation|inhibition of mast cell degranulation|down-regulation of mast cell degranulation|downregulation of mast cell degranulation|negative regulation of mast cell granule exocytosis biological_process owl:Class
GO:0019082 biolink:NamedThing viral protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein. got7fsn_ti biological_process owl:Class
GO:1901217 biolink:NamedThing regulation of holin activity Any process that modulates the frequency, rate or extent of holin activity. got7fsn_ti bf 2012-08-06T10:47:38Z biological_process owl:Class
GO:2000227 biolink:NamedThing negative regulation of pancreatic A cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation. got7fsn_ti negative regulation of pancreatic alpha cell differentiation mah 2010-11-09T03:43:40Z biological_process owl:Class
GO:0071108 biolink:NamedThing protein K48-linked deubiquitination A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein. got7fsn_ti mah 2009-11-12T01:34:01Z biological_process owl:Class
GO:0015228 biolink:NamedThing coenzyme A transmembrane transporter activity Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. got7fsn_ti coenzyme A transporter activity molecular_function owl:Class
GO:0035349 biolink:NamedThing coenzyme A transmembrane transport The process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. got7fsn_ti coenzyme A membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-03-04T03:44:33Z biological_process owl:Class
GO:0140196 biolink:NamedThing positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process. got7fsn_ti pg 2018-02-15T19:13:29Z biological_process owl:Class
GO:0044168 biolink:NamedThing host cell rough endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface. got7fsn_ti host rough endoplasmic reticulum jl 2009-09-04T11:23:28Z cellular_component owl:Class
GO:1905083 biolink:NamedThing negative regulation of mitochondrial translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial translational elongation. got7fsn_ti down regulation of mitochondrial translation elongation|downregulation of mitochondrial translational elongation|down regulation of mitochondrial translational elongation|negative regulation of mitochondrial translation elongation|inhibition of mitochondrial translational elongation|down-regulation of mitochondrial translational elongation|downregulation of mitochondrial translation elongation|down-regulation of mitochondrial translation elongation|inhibition of mitochondrial translation elongation hjd 2016-03-25T17:37:13Z biological_process owl:Class
GO:0030127 biolink:NamedThing COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. got7fsn_ti cellular_component owl:Class
GO:0098749 biolink:NamedThing cerebellar neuron development The process whose specific outcome is the progression of a cerebellar neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0046802 biolink:NamedThing exit of virus from host cell nucleus by nuclear egress The directed movement of an assembled viral particle out of the host cell nucleus by budding and fusion through the nuclear membranes. In this process, enveloped viral particles are formed by budding through the inner nuclear membrane. These perinuclear enveloped particles then fuse with the outer nuclear membrane to deliver a naked capsid into the host cytoplasm. got7fsn_ti capsid egress|nuclear egress|nuclear egress of viral procapsid|egress of viral procapsid from host cell nucleus GO:0039676 VZ:1952 biological_process owl:Class
GO:0005757 biolink:NamedThing mitochondrial permeability transition pore complex A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D). got7fsn_ti mitochondrial PT pore complex|MPTP complex|PTPC cellular_component owl:Class
GO:2000003 biolink:NamedThing positive regulation of DNA damage checkpoint Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint. got7fsn_ti positive regulation of DNA damage response, signal transduction resulting in cell cycle arrest jl 2010-07-15T03:25:10Z biological_process owl:Class
GO:0005456 biolink:NamedThing CMP-N-acetylneuraminate transmembrane transporter activity Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other. got7fsn_ti CMP-sialic acid transmembrane transporter activity Reactome:R-HSA-727807|Reactome:R-HSA-5651942 molecular_function owl:Class
GO:0015782 biolink:NamedThing CMP-N-acetylneuraminate transmembrane transport The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti CMP-N-acetylneuraminate transport|CMP-sialic acid transport biological_process owl:Class
GO:1905101 biolink:NamedThing negative regulation of apoptosome assembly Any process that stops, prevents or reduces the frequency, rate or extent of apoptosome assembly. got7fsn_ti down regulation of apoptosome formation|down regulation of apoptosome assembly|inhibition of apoptosome assembly|downregulation of apoptosome formation|negative regulation of apoptosome formation|down-regulation of apoptosome formation|downregulation of apoptosome assembly|down-regulation of apoptosome assembly|inhibition of apoptosome formation bc 2016-04-04T08:57:51Z biological_process owl:Class
GO:0015080 biolink:NamedThing silver ion transmembrane transporter activity Enables the transfer of silver (Ag) ions from one side of a membrane to the other. got7fsn_ti silver transporter activity molecular_function owl:Class
GO:1902601 biolink:NamedThing silver ion transmembrane transport The directed movement of silver ion across a membrane. got7fsn_ti silver transmembrane transport pr 2013-12-20T11:08:46Z biological_process owl:Class
GO:0043254 biolink:NamedThing regulation of protein-containing complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. got7fsn_ti regulation of protein complex assembly biological_process owl:Class
GO:0110039 biolink:NamedThing positive regulation of nematode male tail tip morphogenesis Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis. got7fsn_ti kmv 2017-07-24T20:32:58Z biological_process owl:Class
GO:0045690 biolink:NamedThing positive regulation of antipodal cell differentiation Any process that activates or increases the frequency, rate or extent of antipodal cell differentiation. got7fsn_ti upregulation of antipodal cell differentiation|stimulation of antipodal cell differentiation|up regulation of antipodal cell differentiation|up-regulation of antipodal cell differentiation|activation of antipodal cell differentiation biological_process owl:Class
GO:0035645 biolink:NamedThing enteric smooth muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. got7fsn_ti intestinal smooth muscle cell differentiation bf 2011-01-21T02:58:58Z biological_process owl:Class
GO:0005368 biolink:NamedThing taurine transmembrane transporter activity Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. got7fsn_ti molecular_function owl:Class
GO:0070719 biolink:NamedThing alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex A protein complex that contains the platelet-derived growth factor alpha receptor (alphaPDGFR; PDGFRA), phospholipase C-gamma-1 (PLC-gamma-1), phosphatidylinositol 3-kinase (PI3K) and the adaptor protein SHP-2, and is involved signaling via the PDGFR signaling pathway. got7fsn_ti PDGFRA-PLC-gamma-1-PI3K-SHP-2 complex, PDGF stimulated mah 2009-06-10T05:04:20Z cellular_component owl:Class
GO:0045028 biolink:NamedThing G protein-coupled purinergic nucleotide receptor activity Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti purinergic nucleotide receptor activity, G protein coupled|G protein coupled purinergic nucleotide receptor activity|P2Y receptor|G-protein coupled purinergic nucleotide receptor activity|P2Y|purinergic nucleotide receptor activity, G-protein coupled molecular_function owl:Class
GO:0000943 biolink:NamedThing retrotransposon nucleocapsid A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog. got7fsn_ti VLP|Virus-like particle Wikipedia:Virus-like_particle cellular_component owl:Class
GO:0019855 biolink:NamedThing calcium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a calcium channel. got7fsn_ti molecular_function owl:Class
GO:1902428 biolink:NamedThing negative regulation of water channel activity Any process that stops, prevents or reduces the frequency, rate or extent of water channel activity. got7fsn_ti downregulation of aquaporin|down regulation of aquaporin|inhibition of water channel activity|inhibition of aquaporin|negative regulation of aquaporin|downregulation of water channel activity|down-regulation of aquaporin|down regulation of water channel activity|down-regulation of water channel activity bf 2013-09-23T12:56:40Z biological_process owl:Class
GO:0005632 biolink:NamedThing inner layer of spore wall Either of the two innermost layers of the spore wall, as described in Saccharomyces. got7fsn_ti cellular_component owl:Class
GO:0046327 biolink:NamedThing glycerol biosynthetic process from pyruvate The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, from other compounds, including pyruvate. got7fsn_ti glyceroneogenesis|glycerol synthesis from pyruvate|glycerol formation from pyruvate|glycerol anabolism from pyruvate biological_process owl:Class
GO:0019432 biolink:NamedThing triglyceride biosynthetic process The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol. got7fsn_ti triglyceride anabolism|triglyceride formation|triglyceride biosynthesis|triglyceride synthesis|triacylglycerol biosynthetic process|triacylglycerol biosynthesis MetaCyc:TRIGLSYN-PWY biological_process owl:Class
GO:0060633 biolink:NamedThing negative regulation of transcription initiation from RNA polymerase II promoter Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter. got7fsn_ti dph 2009-05-18T03:11:26Z biological_process owl:Class
GO:0071916 biolink:NamedThing dipeptide transmembrane transporter activity Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. got7fsn_ti dipeptide transporter activity mah 2010-09-24T10:32:36Z GO:0042936 molecular_function owl:Class
GO:0035442 biolink:NamedThing dipeptide transmembrane transport The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. got7fsn_ti dipeptide membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-13T09:18:33Z biological_process owl:Class
GO:0035033 biolink:NamedThing histone deacetylase regulator activity Binds to and modulates the activity of histone deacetylase. got7fsn_ti See also the molecular function term 'histone deacetylase activity ; GO:0004407'. molecular_function owl:Class
GO:0031063 biolink:NamedThing regulation of histone deacetylation Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones. got7fsn_ti biological_process owl:Class
GO:0103116 biolink:NamedThing ABC-type D-galactofuranose transporter Catalysis of the reaction: alpha-D-galactofuranose + ATP + H2O <=> alpha-D-galactofuranose + hydrogenphosphate + ADP + H+. got7fsn_ti ATP-dependent alpha-D-galactofuranose transporter activity|alpha-D-galactofuranose transporter activity|ATPase-coupled alpha-D-galactofuranose transporter activity EC:7.5.2.9|RHEA:61716|MetaCyc:TRANS-RXN0-491 molecular_function owl:Class
GO:0033215 biolink:NamedThing reductive iron assimilation A process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins. got7fsn_ti iron assimilation by reduction and transport biological_process owl:Class
GO:0006587 biolink:NamedThing serotonin biosynthetic process from tryptophan The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. got7fsn_ti serotonin synthesis from tryptophan|serotonin anabolism from tryptophan|serotonin formation from tryptophan biological_process owl:Class
GO:0098878 biolink:NamedThing neurotransmitter receptor complex Any protein complex that is capable of functioning as a neurotransmitter receptor. got7fsn_ti cellular_component owl:Class
GO:0015546 biolink:NamedThing sulfathiazole transmembrane transporter activity Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group. got7fsn_ti sulphathiazole transporter activity|bicyclomycin/sulfathiazole:hydrogen antiporter activity molecular_function owl:Class
GO:1902599 biolink:NamedThing sulfathiazole transmembrane transport The directed movement of sulfathiazole across a membrane. got7fsn_ti sulfathiazole transport|sulphathiazole transport pr 2013-12-20T11:08:28Z GO:0015906 biological_process owl:Class
GO:2000055 biolink:NamedThing positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification. got7fsn_ti positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|positive regulation of Wnt-activated signaling pathway involved in dorsal/ventral axis specification|positive regulation of Wnt receptor signalling pathway involved in dorsal/ventral axis specification jl 2010-08-20T01:13:40Z biological_process owl:Class
GO:0098654 biolink:NamedThing CENP-A recruiting complex A protein complex that includes Mis16(Yippee family) and/or Mis18 (WD repeat) subunits that is involved in the deposition of centromere specific (CENP-A containing) nucleosomes at the centromere. got7fsn_ti MIS18 complex cellular_component owl:Class
GO:0034426 biolink:NamedThing etioplast membrane Either of the lipid bilayers that surround a etioplast and form the etioplast envelope. got7fsn_ti cellular_component owl:Class
GO:0001929 biolink:NamedThing negative regulation of exocyst assembly Any process that stops, prevents, or reduces the rate or extent of exocyst assembly. got7fsn_ti down regulation of exocyst assembly|down-regulation of exocyst assembly|downregulation of exocyst assembly|inhibition of exocyst assembly biological_process owl:Class
GO:0071367 biolink:NamedThing cellular response to brassinosteroid stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus. got7fsn_ti mah 2009-12-11T03:13:33Z biological_process owl:Class
GO:1905519 biolink:NamedThing negative regulation of presynaptic active zone assembly Any process that stops, prevents or reduces the frequency, rate or extent of presynaptic active zone assembly. got7fsn_ti down-regulation of pre-synaptic active zone assembly|down-regulation of presynaptic active zone formation|down regulation of presynaptic active zone formation|inhibition of pre-synaptic active zone formation|down regulation of presynaptic active zone assembly|inhibition of presynaptic active zone formation|down regulation of pre-synaptic active zone component formation|downregulation of presynaptic active zone assembly|down-regulation of pre-synaptic active zone component assembly|down-regulation of presynaptic active zone assembly|downregulation of presynaptic active zone formation|down-regulation of pre-synaptic active zone formation|negative regulation of presynaptic active zone formation|down regulation of pre-synaptic active zone assembly|negative regulation of pre-synaptic active zone component assembly|negative regulation of pre-synaptic active zone formation|inhibition of presynaptic active zone assembly|negative regulation of pre-synaptic active zone component formation|downregulation of pre-synaptic active zone component formation|inhibition of pre-synaptic active zone assembly|negative regulation of pre-synaptic active zone assembly|down-regulation of pre-synaptic active zone component formation|down regulation of pre-synaptic active zone component assembly|down regulation of pre-synaptic active zone formation|inhibition of pre-synaptic active zone component formation|downregulation of pre-synaptic active zone component assembly|downregulation of pre-synaptic active zone formation|downregulation of pre-synaptic active zone assembly|inhibition of pre-synaptic active zone component assembly rl 2016-10-01T09:38:00Z biological_process owl:Class
GO:0045146 biolink:NamedThing initiation of acetate catabolic process by acetate The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate. got7fsn_ti initiation of acetate breakdown by acetate|initiation of acetate degradation by acetate biological_process owl:Class
GO:0019294 biolink:NamedThing keto-3-deoxy-D-manno-octulosonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria. got7fsn_ti KDO biosynthesis|keto-3-deoxy-D-manno-octulosonic acid anabolism|keto-3-deoxy-D-manno-octulosonic acid biosynthesis|keto-3-deoxy-D-manno-octulosonic acid formation|ketodeoxyoctanoate biosynthetic process|KDO biosynthetic process|keto-3-deoxy-D-manno-octulosonic acid synthesis MetaCyc:KDOSYN-PWY biological_process owl:Class
NCBITaxon:1117 biolink:NamedThing got7fsn_ti owl:Class
GO:0031279 biolink:NamedThing regulation of cyclase activity Any process that modulates the frequency, rate or extent of cyclase activity. got7fsn_ti biological_process owl:Class
GO:0010142 biolink:NamedThing farnesyl diphosphate biosynthetic process, mevalonate pathway The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols. got7fsn_ti acetate-mevalonate pathway|farnesyl diphosphate anabolism, mevalonate pathway|farnesyl diphosphate synthesis, mevalonate pathway|Ac-MVA pathway|farnesyl diphosphate formation, mevalonate pathway|isoprenoid pathway MetaCyc:PWY-922 biological_process owl:Class
GO:0016114 biolink:NamedThing terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. got7fsn_ti terpenoid formation|terpenoid biosynthesis|terpenoid anabolism|terpenoid synthesis Wikipedia:Terpenoid biological_process owl:Class
GO:1904342 biolink:NamedThing negative regulation of colon smooth muscle contraction Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction. got7fsn_ti down regulation of colon smooth muscle contraction|inhibition of colon smooth muscle contraction|down-regulation of colon smooth muscle contraction|downregulation of colon smooth muscle contraction sl 2015-06-11T21:17:05Z biological_process owl:Class
GO:1901725 biolink:NamedThing regulation of histone deacetylase activity Any process that modulates the frequency, rate or extent of histone deacetylase activity. got7fsn_ti rl 2013-01-07T09:14:12Z biological_process owl:Class
GO:0045253 biolink:NamedThing pyruvate dehydrogenase (lipoamide) phosphatase complex A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. got7fsn_ti See also the cellular component term 'cytosolic pyruvate dehydrogenase complex ; GO:0045250'. cellular_component owl:Class
GO:0000817 biolink:NamedThing COMA complex A kinetochore multiprotein complex that bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly. In yeast, consists of Ctf19p, Okp1p, Mcm21p, and Ame1p. got7fsn_ti Ctf19p-Okp1p-Mcm1p-Ame1p complex https://github.com/geneontology/go-ontology/issues/21126 cellular_component owl:Class
GO:0045945 biolink:NamedThing positive regulation of transcription by RNA polymerase III Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III. got7fsn_ti up-regulation of transcription from RNA polymerase III promoter|stimulation of transcription from RNA polymerase III promoter|positive regulation of transcription from Pol III promoter|up regulation of transcription from RNA polymerase III promoter|activation of transcription from RNA polymerase III promoter|positive regulation of transcription from RNA polymerase III promoter|upregulation of transcription from RNA polymerase III promoter biological_process owl:Class
GO:0071058 biolink:NamedThing alpha3-beta1 integrin-CD151 complex A protein complex that consists of an alpha3-beta1 integrin complex bound to the tetraspanin CD151. got7fsn_ti ITGA3-ITGB1-CD151 complex mah 2009-11-03T04:00:39Z cellular_component owl:Class
GO:0002399 biolink:NamedThing MHC class II protein complex assembly The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex. got7fsn_ti biological_process owl:Class
GO:1903594 biolink:NamedThing negative regulation of histamine secretion by mast cell Any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell. got7fsn_ti downregulation of histamine secretion by mast cell|down regulation of histamine secretion by mast cell|down-regulation of histamine secretion by mast cell|inhibition of histamine secretion by mast cell als 2014-11-06T13:19:18Z biological_process owl:Class
GO:0035932 biolink:NamedThing aldosterone secretion The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. got7fsn_ti bf 2011-07-20T01:06:24Z biological_process owl:Class
GO:0010061 biolink:NamedThing regulation of trichoblast fate specification Any process that modulates trichoblast fate specification. got7fsn_ti biological_process owl:Class
GO:0051484 biolink:NamedThing isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway that contributes to terpenoid biosynthesis. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. got7fsn_ti isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid biosynthesis|isopentenyl diphosphate synthesis, mevalonate-independent pathway, during terpenoid synthesis|isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway involved in terpenoid biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway, during terpenoid biosynthetic process|isopentenyl diphosphate formation, mevalonate-independent pathway, during terpenoid formation|isopentenyl diphosphate anabolism, mevalonate-independent pathway, during terpenoid anabolism MetaCyc:NONMEVIPP-PWY biological_process owl:Class
GO:0051483 biolink:NamedThing terpenoid biosynthetic process, mevalonate-independent The chemical reactions and pathways resulting in the formation of terpenoids, independent of mevalonate. Isopentenyl diphosphate (IPP) is the fundamental unit in terpenoid biosynthesis, and in mevalonate-independent biosynthesis, it is produced from pyruvate and glyceraldehyde 3-phosphate via intermediates including 1-deoxy-D-xylulose 5-phosphate. got7fsn_ti mevalonate-independent terpene biosynthetic process|terpenoid synthesis, mevalonate-independent|mevalonate-independent terpenoid biosynthesis|terpene biosynthetic process, mevalonate-independent|terpene biosynthesis, mevalonate-independent|mevalonate-independent terpene biosynthesis|terpenoid anabolism, mevalonate-independent|mevalonate-independent terpenoid biosynthetic process|terpenoid formation, mevalonate-independent biological_process owl:Class
GO:0007510 biolink:NamedThing cardioblast cell fate determination The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti biological_process owl:Class
GO:0003229 biolink:NamedThing ventricular cardiac muscle tissue development The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure. got7fsn_ti ventricular myocardium development dph 2009-10-13T10:56:01Z biological_process owl:Class
GO:0033031 biolink:NamedThing positive regulation of neutrophil apoptotic process Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process. got7fsn_ti stimulation of neutrophil apoptosis|up-regulation of neutrophil apoptosis|up regulation of neutrophil apoptosis|activation of neutrophil apoptosis|upregulation of neutrophil apoptosis|positive regulation of neutrophil apoptosis biological_process owl:Class
GO:0140200 biolink:NamedThing adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate An adrenergic receptor signaling pathway that modulates the frequency or rate of heart contraction. got7fsn_ti pg 2018-02-16T14:33:06Z biological_process owl:Class
GO:0046765 biolink:NamedThing viral budding from nuclear membrane A viral budding that starts with formation of a membrane curvature in the host nuclear membrane. got7fsn_ti viral budding from nuclear membrane by viral capsid envelopment|virus budding from nuclear membrane during viral capsid envelopment|virus budding from nuclear membrane|nuclear membrane viral budding during viral capsid envelopment|virus budding from nuclear membrane by viral capsid envelopment|nuclear membrane viral budding|viral budding from nuclear membrane during viral capsid envelopment GO:0046749 biological_process owl:Class
GO:1905774 biolink:NamedThing regulation of DNA helicase activity Any process that modulates the frequency, rate or extent of ATP-dependent DNA helicase activity. got7fsn_ti regulation of ATP-dependent DNA helicase activity rb 2013-10-15T21:19:52Z GO:1902449 biological_process owl:Class
GO:0099084 biolink:NamedThing postsynaptic specialization organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane. got7fsn_ti post synaptic specialization organization|post-synaptic specialization organization|postsynaptic specialization organisation pr 2011-07-27T05:17:12Z biological_process owl:Class
GO:2000320 biolink:NamedThing negative regulation of T-helper 17 cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation. got7fsn_ti negative regulation of T-helper 17 cell development mah 2011-01-18T01:44:31Z biological_process owl:Class
GO:1903978 biolink:NamedThing regulation of microglial cell activation Any process that modulates the frequency, rate or extent of microglial cell activation. got7fsn_ti nc 2015-03-02T15:17:33Z biological_process owl:Class
GO:0045053 biolink:NamedThing protein retention in Golgi apparatus The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known. got7fsn_ti protein-Golgi retention|maintenance of protein location in Golgi apparatus|retention of protein in Golgi biological_process owl:Class
GO:0022025 biolink:NamedThing leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. got7fsn_ti leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment biological_process owl:Class
GO:1903183 biolink:NamedThing negative regulation of SUMO transferase activity Any process that stops, prevents or reduces the frequency, rate or extent of SUMO ligase activity. got7fsn_ti negative regulation of SUMO conjugating enzyme activity|down regulation of SMT3 conjugating enzyme|down-regulation of SUMO ligase activity|downregulation of SMT3 conjugating enzyme|inhibition of SMT3 conjugating enzyme|down-regulation of SUMO conjugating enzyme activity|down regulation of SUMO ligase activity|inhibition of SUMO conjugating enzyme activity|downregulation of SUMO conjugating enzyme activity|down-regulation of SMT3 conjugating enzyme|down regulation of SUMO conjugating enzyme activity|negative regulation of SMT3 conjugating enzyme|inhibition of SUMO ligase activity|downregulation of SUMO ligase activity bf 2014-07-14T14:01:46Z biological_process owl:Class
GO:0050823 biolink:NamedThing peptide antigen stabilization Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded. got7fsn_ti peptide antigen stabilization activity biological_process owl:Class
GO:1901588 biolink:NamedThing dendritic microtubule Any microtubule in a dendrite, a neuron projection. got7fsn_ti microtubulus of dendrite|microtubule of dendrite pr 2012-11-07T14:37:30Z NIF_Subcellular:sao110773650 cellular_component owl:Class
GO:1902963 biolink:NamedThing negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. got7fsn_ti inhibition of metalloendoprotease activity involved in APP catabolic process|negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoproteinase activity involved in APP catabolism|negative regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|down-regulation of metalloendoproteinase activity involved in APP catabolic process|down regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|negative regulation of metalloendoproteinase activity involved in APP catabolic process|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|down-regulation of metalloendoprotease activity involved in APP catabolism|down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoprotease activity involved in APP catabolism|inhibition of metalloendopeptidase activity involved in amyloid precursor protein breakdown|down regulation of metalloendoproteinase activity involved in APP catabolism|negative regulation of metalloendoproteinase activity involved in APP catabolism|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|down regulation of metalloendoprotease activity involved in APP catabolism|inhibition of metalloendoproteinase activity involved in APP catabolism|negative regulation of metalloendoprotease activity involved in APP catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|down regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|down regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|inhibition of metalloendoproteinase activity involved in amyloid precursor protein breakdown|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendopeptidase activity involved in APP catabolic process|downregulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|inhibition of metalloendopeptidase activity involved in APP catabolism|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|downregulation of metalloendoproteinase activity involved in APP catabolism|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendopeptidase activity involved in APP catabolic process|downregulation of metalloendoprotease activity involved in APP catabolism|down regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|down-regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|inhibition of metalloendoprotease activity involved in APP catabolism|negative regulation of metalloendopeptidase activity involved in APP catabolism|inhibition of metalloendopeptidase activity involved in APP catabolic process|downregulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|inhibition of metalloendoprotease activity involved in amyloid precursor protein breakdown|down regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|down regulation of metalloendoprotease activity involved in APP catabolic process|down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolism|inhibition of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|negative regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|inhibition of metalloendoproteinase activity involved in APP catabolic process|down regulation of metalloendopeptidase activity involved in APP catabolic process|down-regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|down regulation of metalloendopeptidase activity involved in APP catabolism|inhibition of metalloendoproteinase activity involved in amyloid precursor protein degradation|down regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|inhibition of metalloendopeptidase activity involved in amyloid precursor protein degradation|inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|downregulation of metalloendoprotease activity involved in amyloid precursor protein degradation|down regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|downregulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|downregulation of metalloendoprotease activity involved in APP catabolic process|inhibition of metalloendopeptidase activity involved in amyloid precursor protein catabolism|downregulation of metalloendopeptidase activity involved in APP catabolic process|down regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|down-regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|down regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|downregulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|down regulation of metalloendoproteinase activity involved in APP catabolic process|downregulation of metalloendoproteinase activity involved in APP catabolic process|downregulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|down-regulation of metalloendoprotease activity involved in APP catabolic process|inhibition of metalloendoprotease activity involved in amyloid precursor protein degradation|downregulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|inhibition of metalloendoprotease activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|downregulation of metalloendopeptidase activity involved in APP catabolism|down-regulation of metalloendopeptidase activity involved in APP catabolism sjp 2014-05-06T09:12:01Z biological_process owl:Class
GO:0045041 biolink:NamedThing protein import into mitochondrial intermembrane space The import of proteins into the space between the inner and outer mitochondrial membranes. got7fsn_ti protein import into mitochondrial IMS|mitochondrial intermembrane space protein import|protein transport into mitochondrial intermembrane space|protein import into mitochondrial intermembrane space, nonconservative|protein import into mitochondrial intermembrane space, direct|protein transport into mitochondrial IMS GO:0045043|GO:0045044 biological_process owl:Class
GO:0060224 biolink:NamedThing regulation of retinal rod cell fate commitment Any process that modulates the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye. got7fsn_ti biological_process owl:Class
GO:0042720 biolink:NamedThing mitochondrial inner membrane peptidase complex Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space. got7fsn_ti IMP|mitochondrion inner membrane peptidase complex cellular_component owl:Class
GO:0004105 biolink:NamedThing choline-phosphate cytidylyltransferase activity Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline. got7fsn_ti CTP-phosphocholine cytidylyltransferase activity|CTP:choline-phosphate cytidylyltransferase activity|CTP:phosphocholine cytidylyltransferase activity|CDP-choline synthetase activity|CTP:phosphorylcholine cytidylyltransferase activity|phosphorylcholine cytidylyltransferase activity|cytidine diphosphocholine pyrophosphorylase activity|phosphorylcholine:CTP cytidylyltransferase activity|choline phosphate cytidylyltransferase activity|CDP-choline pyrophosphorylase activity|phosphocholine cytidylyltransferase activity|phosphorylcholine transferase activity Reactome:R-HSA-1483081|EC:2.7.7.15|MetaCyc:2.7.7.15-RXN|RHEA:18997 molecular_function owl:Class
GO:0060833 biolink:NamedThing Wnt signaling pathway involved in animal/vegetal axis specification The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the specification of the animal/vegetal axis of an oocyte. got7fsn_ti Wnt receptor signalling pathway involved in animal/vegetal axis specification|Wnt- activated signaling pathway involved in animal/vegetal axis specification|Wnt receptor signaling pathway involved in animal/vegetal axis specification dph 2009-08-11T03:20:39Z biological_process owl:Class
GO:0003042 biolink:NamedThing vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure. got7fsn_ti vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure biological_process owl:Class
CHEBI:27570 biolink:NamedThing got7fsn_ti owl:Class
GO:0034693 biolink:NamedThing U11/U12 snRNP A ribonucleoprotein complex that is formed by the association of the U11 and U12 small nuclear ribonucleoproteins. got7fsn_ti snRNP U11/U12|18S U11/U12 snRNP cellular_component owl:Class
GO:0015086 biolink:NamedThing cadmium ion transmembrane transporter activity Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other. got7fsn_ti zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity|zinc, cadmium uptake permease activity molecular_function owl:Class
GO:1905879 biolink:NamedThing regulation of oogenesis Any process that modulates the frequency, rate or extent of oogenesis. got7fsn_ti regulation of ovum development hbye 2017-01-31T09:31:05Z biological_process owl:Class
GO:0001834 biolink:NamedThing trophectodermal cell proliferation The proliferation of cells in the trophectoderm. got7fsn_ti trophectoderm cell proliferation See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. biological_process owl:Class
GO:0051894 biolink:NamedThing positive regulation of focal adhesion assembly Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. got7fsn_ti up regulation of focal adhesion formation|activation of focal adhesion formation|upregulation of focal adhesion formation|up-regulation of focal adhesion formation|stimulation of focal adhesion formation biological_process owl:Class
GO:0021625 biolink:NamedThing oculomotor nerve maturation A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle. got7fsn_ti CN III maturation biological_process owl:Class
GO:0061170 biolink:NamedThing negative regulation of hair follicle placode formation Any process that decreases the rate, frequency, or extent of hair follicle placode formation, the developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. got7fsn_ti dph 2010-06-25T01:10:48Z biological_process owl:Class
GO:0046599 biolink:NamedThing regulation of centriole replication Any process that modulates the frequency, rate or extent of the formation of a daughter centriole of an existing centriole. got7fsn_ti biological_process owl:Class
GO:0071466 biolink:NamedThing cellular response to xenobiotic stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti cellular response to drug https://github.com/geneontology/go-ontology/issues/19460 mah 2009-12-18T11:38:48Z GO:0035690 biological_process owl:Class
GO:2000267 biolink:NamedThing negative regulation of blood coagulation, intrinsic pathway Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway. got7fsn_ti mah 2010-11-23T11:45:46Z biological_process owl:Class
GO:2000006 biolink:NamedThing regulation of metanephric comma-shaped body morphogenesis Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis. got7fsn_ti jl 2010-07-30T02:17:12Z biological_process owl:Class
GO:1902910 biolink:NamedThing positive regulation of melanosome transport Any process that activates or increases the frequency, rate or extent of melanosome transport. got7fsn_ti up regulation of melanosome transport|activation of melanosome transport|upregulation of melanosome transport|up-regulation of melanosome transport als 2014-04-17T11:40:34Z biological_process owl:Class
GO:0019829 biolink:NamedThing ATPase-coupled cation transmembrane transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). got7fsn_ti ATP-dependent cation transmembrane transporter activity|plasma membrane cation-transporting ATPase|cation-transporting ATPase activity|cation ABC transporter Reactome:R-HSA-5251989|Reactome:R-HSA-5692480 molecular_function owl:Class
GO:2000045 biolink:NamedThing regulation of G1/S transition of mitotic cell cycle Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. got7fsn_ti Note that this process is usually achieved by the regulation of the G1 cyclin-dependent protein kinase, consider annotating to the child term 'regulation of cyclin-dependent protein kinase activity involved in G1/S ; GO:0031657'. tb 2010-08-19T09:10:56Z biological_process owl:Class
GO:0071425 biolink:NamedThing hematopoietic stem cell proliferation The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop. got7fsn_ti hemopoietic stem cell proliferation mah 2009-12-16T10:22:52Z biological_process owl:Class
GO:0048057 biolink:NamedThing R3/R4 development The process whose specific outcome is the progression of the R3 and R4 pair of photoreceptors in the eye over time, from their formation to the mature structures. R3 and R4 are paired photoreceptors that contribute to the outer rhabdomeres. An example of this process is found in Drosophila melanogaster. got7fsn_ti biological_process owl:Class
GO:0010868 biolink:NamedThing negative regulation of triglyceride biosynthetic process Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol. got7fsn_ti negative regulation of triacylglycerol biosynthetic process biological_process owl:Class
GO:0000220 biolink:NamedThing vacuolar proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. got7fsn_ti vacuolar hydrogen ion-transporting ATPase V0 domain Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. cellular_component owl:Class
GO:0075030 biolink:NamedThing modulation of formation of symbiont germ tube hook structure for appressorium development Any process that modulates the frequency, rate or extent of symbiont germ tube hook structure formation. got7fsn_ti regulation of formation of symbiont germ tube hook structure on or near host|modulation of symbiont germ tube hook structure formation on or near host|modulation of germ tube tip of symbiont on or near the exterior of host biological_process owl:Class
CL:0000775 biolink:NamedThing got7fsn_ti owl:Class
GO:1904445 biolink:NamedThing negative regulation of establishment of Sertoli cell barrier Any process that stops, prevents or reduces the frequency, rate or extent of establishment of Sertoli cell barrier. got7fsn_ti down regulation of establishment of Sertoli cell barrier|downregulation of establishment of BTB|inhibition of establishment of blood-testis barrier|down-regulation of establishment of BTB|downregulation of establishment of SCB|inhibition of establishment of BTB|inhibition of establishment of Sertoli cell barrier|negative regulation of establishment of BTB|downregulation of establishment of blood-testis barrier|down regulation of establishment of SCB|down regulation of establishment of BTB|down-regulation of establishment of SCB|downregulation of establishment of Sertoli cell barrier|negative regulation of establishment of blood-testis barrier|inhibition of establishment of SCB|down-regulation of establishment of Sertoli cell barrier|down regulation of establishment of blood-testis barrier|down-regulation of establishment of blood-testis barrier|negative regulation of establishment of SCB sl 2015-07-06T16:00:48Z biological_process owl:Class
GO:0044726 biolink:NamedThing protection of DNA demethylation of female pronucleus The protection of the maternal genome from DNA demethylation in the zygote following fertilization. got7fsn_ti jl 2012-10-24T14:10:36Z biological_process owl:Class
GO:1901670 biolink:NamedThing negative regulation of superoxide dismutase activity Any process that stops, prevents or reduces the frequency, rate or extent of superoxide dismutase activity. got7fsn_ti inhibition of cuprein|downregulation of hemocuprein|down-regulation of Mn, Fe superoxide dismutase|inhibition of manganese superoxide oxidoreductase|inhibition of SOD-3|down-regulation of superoxide dismutase activity|negative regulation of zinc superoxide oxidoreductase|down-regulation of superoxide dismutase II|down-regulation of manganese superoxide oxidoreductase|negative regulation of SOD-4|downregulation of iron superoxide oxidoreductase|downregulation of SODF|inhibition of nickel superoxide oxidoreductase|down-regulation of manganese superoxide dismutase activity|down regulation of superoxide:superoxide oxidoreductase activity|downregulation of SOD-4|negative regulation of superoxide dismutase II|downregulation of hepatocuprein|down-regulation of Mn-SOD|negative regulation of manganese superoxide dismutase activity|negative regulation of Fe-SOD|down regulation of Fe-SOD|downregulation of SOD-3|negative regulation of iron superoxide oxidoreductase|negative regulation of iron superoxide dismutase activity|down-regulation of copper, zinc superoxide dismutase activity|negative regulation of Cu-Zn superoxide dismutase activity|negative regulation of SOD-3|down-regulation of cuprein|down regulation of cuprein|down-regulation of SODF|inhibition of Mn-SOD|down-regulation of nickel superoxide dismutase activity|negative regulation of Cu,Zn-SOD|down-regulation of iron superoxide oxidoreductase|inhibition of superoxide dismutase activity|down regulation of superoxide dismutase activity|inhibition of superoxide dismutase II|down regulation of SOD-3|negative regulation of hemocuprein|down regulation of Mn-SOD|down-regulation of cytocuprein|negative regulation of copper, zinc superoxide dismutase activity|down regulation of SOD-1|down regulation of erythrocuprein|negative regulation of superoxide:superoxide oxidoreductase activity|down regulation of superoxide dismutase II|negative regulation of erythrocuprein|downregulation of nickel superoxide dismutase activity|down-regulation of superoxide dismutase I|down-regulation of SOD-1|downregulation of Fe-SOD|down regulation of SOD|negative regulation of superoxide dismutase I|inhibition of SODS|negative regulation of Mn-SOD|inhibition of Cu,Zn-SOD|downregulation of copper, zinc superoxide dismutase activity|down-regulation of SODS|downregulation of Mn-SOD|down regulation of manganese superoxide dismutase activity|downregulation of iron superoxide dismutase activity|down regulation of zinc superoxide oxidoreductase|inhibition of hemocuprein|downregulation of Mn, Fe superoxide dismutase|inhibition of SODF|inhibition of zinc superoxide oxidoreductase|down regulation of iron superoxide oxidoreductase|down regulation of nickel superoxide oxidoreductase|inhibition of hepatocuprein|negative regulation of manganese superoxide oxidoreductase|downregulation of superoxide dismutase I|downregulation of zinc superoxide oxidoreductase|negative regulation of SOD|negative regulation of SOD-2|downregulation of manganese superoxide dismutase activity|negative regulation of SOD-1|negative regulation of hepatocuprein|downregulation of nickel superoxide oxidoreductase|downregulation of cuprein|inhibition of superoxide:superoxide oxidoreductase activity|down regulation of SOD-2|downregulation of Cu-Zn superoxide dismutase activity|down-regulation of SOD-2|down regulation of iron superoxide dismutase activity|down-regulation of hemocuprein|down-regulation of nickel superoxide oxidoreductase|inhibition of iron superoxide dismutase activity|inhibition of SOD-4|down-regulation of superoxide:superoxide oxidoreductase activity|negative regulation of nickel superoxide oxidoreductase|inhibition of superoxide dismutase I|inhibition of Fe-SOD|negative regulation of cuprein|negative regulation of nickel superoxide dismutase activity|inhibition of Cu-Zn superoxide dismutase activity|inhibition of iron superoxide oxidoreductase|down regulation of Cu,Zn-SOD|inhibition of Mn, Fe superoxide dismutase|down-regulation of zinc superoxide oxidoreductase|downregulation of SOD-1|down regulation of SODF|downregulation of cytocuprein|inhibition of copper, zinc superoxide dismutase activity|downregulation of superoxide dismutase activity|down regulation of manganese superoxide oxidoreductase|down-regulation of SOD-3|down regulation of ferrisuperoxide dismutase activity|down regulation of cytocuprein|down regulation of nickel superoxide dismutase activity|negative regulation of cytocuprein|downregulation of erythrocuprein|down-regulation of SOD|downregulation of SOD|down-regulation of hepatocuprein|down regulation of hemocuprein|negative regulation of ferrisuperoxide dismutase activity|down regulation of SODS|downregulation of manganese superoxide oxidoreductase|down regulation of copper, zinc superoxide dismutase activity|down-regulation of Fe-SOD|down regulation of Cu-Zn superoxide dismutase activity|negative regulation of SODF|downregulation of SOD-2|downregulation of SODS|inhibition of ferrisuperoxide dismutase activity|down regulation of SOD-4|inhibition of manganese superoxide dismutase activity|down-regulation of SOD-4|downregulation of Cu,Zn-SOD|down-regulation of ferrisuperoxide dismutase activity|down regulation of superoxide dismutase I|inhibition of SOD|down regulation of Mn, Fe superoxide dismutase|negative regulation of SODS|inhibition of nickel superoxide dismutase activity|down-regulation of erythrocuprein|inhibition of SOD-2|negative regulation of Mn, Fe superoxide dismutase|inhibition of cytocuprein|inhibition of SOD-1|downregulation of superoxide:superoxide oxidoreductase activity|down-regulation of iron superoxide dismutase activity|downregulation of superoxide dismutase II|down-regulation of Cu,Zn-SOD|down regulation of hepatocuprein|inhibition of erythrocuprein|down-regulation of Cu-Zn superoxide dismutase activity|downregulation of ferrisuperoxide dismutase activity tb 2012-11-21T21:36:07Z biological_process owl:Class
GO:1990898 biolink:NamedThing meiotic DNA double-strand break clipping The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP). got7fsn_ti al 2015-11-10T17:12:27Z biological_process owl:Class
GO:0032277 biolink:NamedThing negative regulation of gonadotropin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin. got7fsn_ti downregulation of gonadotropin secretion|negative regulation of gonadotrophin secretion|down regulation of gonadotropin secretion|down-regulation of gonadotropin secretion|inhibition of gonadotropin secretion biological_process owl:Class
GO:2000087 biolink:NamedThing regulation of mesonephric glomerulus development Any process that modulates the frequency, rate or extent of mesonephric glomerulus development. got7fsn_ti dph 2010-09-03T06:09:19Z biological_process owl:Class
GO:0034246 biolink:NamedThing mitochondrial transcription factor activity Interacting with the mitochondrial promoter DNA to modulate transcription by the mitochondrial RNA polymerase. got7fsn_ti mitochondrial polymerase transcription factor activity|sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity|mitochondrial sequence-specific DNA binding transcription factor activity|transcription factor activity, mitochondrial proximal promoter sequence-specific binding|transcription factor activity, mitochondrial RNA polymerase core promoter sequence-specific DNA binding|mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity|mitochondrial sequence-specific DNA-binding transcription factor activity|mitochondrial DNA-binding transcription factor activity|mitochondrial RNA polymerase transcription factor activity, sequence-specific DNA binding|mitochondrial RNA polymerase binding promoter specificity activity|mitochondrial RNA polymerase promoter specificity activity|transcription factor activity, mitochondrial RNA polymerase core promoter proximal region sequence-specific binding|mitochondrial transcription initiation factor activity|mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity|mitochondrial transcription factor activity https://github.com/geneontology/go-ontology/issues/14908|https://github.com/geneontology/go-ontology/issues/19891 krc 2011-01-27T01:55:21Z GO:0001143|GO:0000998|GO:0001142|GO:0001144 molecular_function owl:Class
GO:0032786 biolink:NamedThing positive regulation of DNA-templated transcription, elongation Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. got7fsn_ti positive regulation of transcription elongation|activation of RNA elongation|up regulation of RNA elongation|positive regulation of transcription elongation, DNA-dependent|up-regulation of RNA elongation|positive regulation of transcriptional elongation|upregulation of RNA elongation|positive transcription elongation regulator activity|stimulation of RNA elongation|positive regulation of DNA-dependent transcription, elongation biological_process owl:Class
GO:0005889 biolink:NamedThing potassium:proton exchanging ATPase complex A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present. got7fsn_ti hydrogen/potassium-exchanging ATPase complex|hydrogen:potassium-exchanging ATPase complex|proton pump cellular_component owl:Class
GO:0070334 biolink:NamedThing alpha6-beta4 integrin-laminin 5 complex A protein complex that consists of an alpha6-beta4 integrin complex bound to laminin 5. got7fsn_ti alpha6-beta4 integrin-laminin-332 complex|ITGA6-ITGB4-LAMA5 complex cellular_component owl:Class
GO:0072597 biolink:NamedThing maintenance of protein location in chloroplast Any process in which a protein is maintained in a specific location in a chloroplast, and is prevented from moving elsewhere. got7fsn_ti mah 2011-02-14T02:17:48Z biological_process owl:Class
GO:1902226 biolink:NamedThing regulation of macrophage colony-stimulating factor signaling pathway Any process that modulates the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway. got7fsn_ti regulation of macrophage colony-stimulating factor signalling pathway|regulation of M-CSF signaling pathway lb 2013-06-14T06:28:42Z biological_process owl:Class
GO:0006963 biolink:NamedThing positive regulation of antibacterial peptide biosynthetic process Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis. got7fsn_ti stimulation of antibacterial peptide biosynthetic process|activation of antibacterial peptide biosynthetic process|up regulation of antibacterial peptide biosynthetic process|upregulation of antibacterial peptide biosynthetic process|antibacterial polypeptide induction|up-regulation of antibacterial peptide biosynthetic process|antibacterial peptide induction biological_process owl:Class
GO:0015556 biolink:NamedThing C4-dicarboxylate transmembrane transporter activity Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015740 biolink:NamedThing C4-dicarboxylate transport The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. got7fsn_ti biological_process owl:Class
GO:0098876 biolink:NamedThing vesicle-mediated transport to the plasma membrane The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis. got7fsn_ti biological_process owl:Class
NCBITaxon:6073 biolink:NamedThing got7fsn_ti owl:Class
GO:1901248 biolink:NamedThing positive regulation of lung ciliated cell differentiation Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation. got7fsn_ti up regulation of lung ciliated cell differentiation|activation of lung ciliated cell differentiation|upregulation of lung ciliated cell differentiation|up-regulation of lung ciliated cell differentiation vk 2012-08-08T08:59:05Z biological_process owl:Class
GO:1904747 biolink:NamedThing positive regulation of apoptotic process involved in development Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development. got7fsn_ti up-regulation of commitment to apoptosis involved in anatomical structure development|up regulation of activation of apoptosis involved in anatomical structure development|activation of induction of apoptosis by p53 involved in development of an anatomical structure|activation of apoptosis involved in development of an anatomical structure|up-regulation of induction of apoptosis involved in development of an anatomical structure|positive regulation of apoptosis signaling involved in development of an anatomical structure|up regulation of apoptotic program involved in anatomical structure development|activation of apoptotic program involved in anatomical structure development|up regulation of apoptosis involved in anatomical structure development|positive regulation of apoptotic cell death involved in anatomical structure development|up regulation of type I programmed cell death involved in development of an anatomical structure|upregulation of apoptosis signaling involved in anatomical structure development|up regulation of commitment to apoptosis involved in development of an anatomical structure|positive regulation of apoptosis involved in anatomical structure development|upregulation of commitment to apoptosis involved in development of an anatomical structure|up-regulation of commitment to apoptosis involved in development of an anatomical structure|positive regulation of apoptotic process involved in anatomical structure development|positive regulation of signaling (initiator) caspase activity involved in anatomical structure development|activation of apoptotic process involved in anatomical structure development|positive regulation of apoptotic programmed cell death involved in anatomical structure development|upregulation of apoptotic programmed cell death involved in anatomical structure development|upregulation of apoptosis involved in anatomical structure development|up-regulation of apoptosis signaling involved in development of an anatomical structure|activation of apoptotic programmed cell death involved in development of an anatomical structure|activation of apoptosis involved in anatomical structure development|activation of apoptotic cell death involved in development of an anatomical structure|upregulation of apoptosis involved in development of an anatomical structure|up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|up regulation of induction of apoptosis involved in anatomical structure development|positive regulation of induction of apoptosis by p53 involved in anatomical structure development|up regulation of apoptotic program involved in development of an anatomical structure|up regulation of apoptotic programmed cell death involved in development of an anatomical structure|activation of apoptotic process involved in development of an anatomical structure|activation of induction of apoptosis involved in development of an anatomical structure|positive regulation of type I programmed cell death involved in anatomical structure development|up-regulation of apoptotic programmed cell death involved in development of an anatomical structure|up-regulation of apoptotic cell death involved in development of an anatomical structure|up regulation of type I programmed cell death involved in anatomical structure development|upregulation of apoptosis signaling involved in development of an anatomical structure|upregulation of type I programmed cell death involved in development of an anatomical structure|upregulation of apoptotic process involved in anatomical structure development|upregulation of commitment to apoptosis involved in anatomical structure development|positive regulation of activation of apoptosis involved in anatomical structure development|up-regulation of apoptosis activator activity involved in development of an anatomical structure|up regulation of activation of apoptosis involved in development of an anatomical structure|up regulation of apoptotic cell death involved in development of an anatomical structure|positive regulation of commitment to apoptosis involved in anatomical structure development|up-regulation of apoptosis involved in development of an anatomical structure|positive regulation of apoptosis activator activity involved in anatomical structure development|up-regulation of type I programmed cell death involved in anatomical structure development|positive regulation of apoptotic cell death involved in development of an anatomical structure|activation of type I programmed cell death involved in development of an anatomical structure|activation of signaling (initiator) caspase activity involved in development of an anatomical structure|positive regulation of programmed cell death by apoptosis involved in anatomical structure development|upregulation of activation of apoptosis involved in development of an anatomical structure|positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure|up-regulation of apoptotic program involved in anatomical structure development|positive regulation of type I programmed cell death involved in development of an anatomical structure|upregulation of apoptotic cell death involved in development of an anatomical structure|activation of activation of apoptosis involved in development of an anatomical structure|activation of type I programmed cell death involved in anatomical structure development|upregulation of apoptotic process involved in development of an anatomical structure|upregulation of type I programmed cell death involved in anatomical structure development|upregulation of apoptotic process involved in development|up-regulation of induction of apoptosis involved in anatomical structure development|upregulation of apoptotic program involved in development of an anatomical structure|positive regulation of activation of apoptosis involved in development of an anatomical structure|upregulation of apoptosis activator activity involved in anatomical structure development|upregulation of apoptotic programmed cell death involved in development of an anatomical structure|upregulation of induction of apoptosis by p53 involved in anatomical structure development|activation of apoptosis activator activity involved in anatomical structure development|up regulation of apoptotic process involved in development|up-regulation of induction of apoptosis by p53 involved in anatomical structure development|upregulation of induction of apoptosis involved in anatomical structure development|activation of apoptotic program involved in development of an anatomical structure|upregulation of induction of apoptosis involved in development of an anatomical structure|upregulation of apoptotic program involved in anatomical structure development|up regulation of apoptosis activator activity involved in anatomical structure development|up regulation of induction of apoptosis involved in development of an anatomical structure|positive regulation of induction of apoptosis involved in anatomical structure development|up regulation of apoptosis activator activity involved in development of an anatomical structure|up regulation of apoptosis signaling involved in anatomical structure development|up regulation of apoptotic cell death involved in anatomical structure development|positive regulation of apoptosis activator activity involved in development of an anatomical structure|up-regulation of programmed cell death by apoptosis involved in anatomical structure development|up regulation of signaling (initiator) caspase activity involved in anatomical structure development|upregulation of activation of apoptosis involved in anatomical structure development|up regulation of commitment to apoptosis involved in anatomical structure development|upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure|up-regulation of apoptotic programmed cell death involved in anatomical structure development|up-regulation of apoptotic process involved in anatomical structure development|up regulation of induction of apoptosis by p53 involved in development of an anatomical structure|positive regulation of commitment to apoptosis involved in development of an anatomical structure|upregulation of signaling (initiator) caspase activity involved in anatomical structure development|up regulation of apoptosis involved in development of an anatomical structure|up regulation of apoptotic programmed cell death involved in anatomical structure development|up-regulation of apoptosis signaling involved in anatomical structure development|activation of apoptosis activator activity involved in development of an anatomical structure|positive regulation of apoptotic program involved in anatomical structure development|activation of apoptotic process involved in development|activation of programmed cell death by apoptosis involved in development of an anatomical structure|positive regulation of apoptosis signaling involved in anatomical structure development|up regulation of apoptosis signaling involved in development of an anatomical structure|activation of apoptotic programmed cell death involved in anatomical structure development|upregulation of apoptosis activator activity involved in development of an anatomical structure|upregulation of programmed cell death by apoptosis involved in anatomical structure development|positive regulation of apoptotic programmed cell death involved in development of an anatomical structure|up-regulation of apoptotic process involved in development|up-regulation of activation of apoptosis involved in anatomical structure development|up regulation of apoptotic process involved in anatomical structure development|positive regulation of apoptosis involved in development of an anatomical structure|up-regulation of apoptotic cell death involved in anatomical structure development|upregulation of apoptotic cell death involved in anatomical structure development|activation of induction of apoptosis by p53 involved in anatomical structure development|up-regulation of activation of apoptosis involved in development of an anatomical structure|up-regulation of apoptotic process involved in development of an anatomical structure|up-regulation of signaling (initiator) caspase activity involved in anatomical structure development|up regulation of programmed cell death by apoptosis involved in development of an anatomical structure|up regulation of programmed cell death by apoptosis involved in anatomical structure development|activation of commitment to apoptosis involved in development of an anatomical structure|upregulation of programmed cell death by apoptosis involved in development of an anatomical structure|up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure|up-regulation of apoptotic program involved in development of an anatomical structure|activation of activation of apoptosis involved in anatomical structure development|up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure|up-regulation of apoptosis activator activity involved in anatomical structure development|positive regulation of apoptotic program involved in development of an anatomical structure|activation of commitment to apoptosis involved in anatomical structure development|positive regulation of apoptotic process involved in development of an anatomical structure|activation of programmed cell death by apoptosis involved in anatomical structure development|up-regulation of type I programmed cell death involved in development of an anatomical structure|activation of apoptotic cell death involved in anatomical structure development|positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|activation of apoptosis signaling involved in anatomical structure development|up regulation of apoptotic process involved in development of an anatomical structure|activation of induction of apoptosis involved in anatomical structure development|positive regulation of induction of apoptosis involved in development of an anatomical structure|activation of apoptosis signaling involved in development of an anatomical structure|positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure|activation of signaling (initiator) caspase activity involved in anatomical structure development|upregulation of induction of apoptosis by p53 involved in development of an anatomical structure|up regulation of induction of apoptosis by p53 involved in anatomical structure development|up-regulation of apoptosis involved in anatomical structure development U4PR86 in PMID:22801495 inferred from mutant phenotype es 2015-10-19T14:12:34Z biological_process owl:Class
GO:0015625 biolink:NamedThing ABC-type ferric hydroxamate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in). got7fsn_ti ATPase-coupled ferric-hydroxamate transmembrane transporter activity|ferric-hydroxamate-transporting ATPase activity|ATP-dependent ferric-hydroxamate transmembrane transporter activity|ferric-hydroxamate transmembrane transporter activity|ferric-hydroxamate porter activity|ATP-dependent iron-chelate transporter activity|ATPase-coupled iron-chelate transporter activity|ferric-hydroxamate ABC transporter|iron-chelate-transporting ATPase activity https://github.com/geneontology/go-ontology/issues/17164 GO:0015409|GO:0102026|GO:0015623|GO:0015622 MetaCyc:3.6.3.34-RXN|MetaCyc:ABC-11-RXN|MetaCyc:ABC-9-RXN|EC:7.2.2.16 molecular_function owl:Class
GO:0031952 biolink:NamedThing regulation of protein autophosphorylation Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. got7fsn_ti regulation of protein amino acid autophosphorylation biological_process owl:Class
GO:1902034 biolink:NamedThing negative regulation of hematopoietic stem cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation. got7fsn_ti negative regulation of hemopoietic stem cell proliferation|down-regulation of hematopoietic stem cell proliferation|inhibition of hematopoietic stem cell proliferation|inhibition of hemopoietic stem cell proliferation|down regulation of hemopoietic stem cell proliferation|down-regulation of hemopoietic stem cell proliferation|downregulation of hematopoietic stem cell proliferation|down regulation of hematopoietic stem cell proliferation|downregulation of hemopoietic stem cell proliferation ss 2013-04-02T05:13:24Z biological_process owl:Class
GO:2000017 biolink:NamedThing positive regulation of determination of dorsal identity Any process that activates or increases the frequency, rate or extent of determination of dorsal identity. got7fsn_ti positive regulation of determination of adaxial identity jl 2010-07-15T03:27:59Z biological_process owl:Class
GO:0001607 biolink:NamedThing neuromedin U receptor activity Combining with neuromedin U to initiate a change in cell activity. got7fsn_ti NMUR activity molecular_function owl:Class
GO:0009787 biolink:NamedThing regulation of abscisic acid-activated signaling pathway Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling. got7fsn_ti regulation of abscisic acid mediated signalling|regulation of abscisic acid mediated signaling pathway biological_process owl:Class
GO:0042950 biolink:NamedThing salicin transmembrane transporter activity Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042948 biolink:NamedThing salicin transport The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0015117 biolink:NamedThing thiosulfate transmembrane transporter activity Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other. got7fsn_ti thiosulphate transporter activity|thiosulfate permease activity RHEA:32807 molecular_function owl:Class
GO:0002794 biolink:NamedThing regulation of antimicrobial peptide secretion Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion. got7fsn_ti biological_process owl:Class
GO:1905271 biolink:NamedThing regulation of proton-transporting ATP synthase activity, rotational mechanism Any process that modulates the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism. got7fsn_ti regulation of hydrogen ion transporting ATP synthase activity, rotational mechanism|regulation of hydrogen ion transporting two-sector ATPase activity|regulation of H+-transporting ATP synthase activity|regulation of hydrogen ion translocating F-type ATPase activity als 2016-06-16T12:09:49Z biological_process owl:Class
GO:0060197 biolink:NamedThing cloacal septation The separation of the single opening of the digestive, urinary, and reproductive tracts, the cloaca, into multiple isolated openings during development. got7fsn_ti cloaca septation biological_process owl:Class
CL:0010009 biolink:NamedThing got7fsn_ti owl:Class
GO:0009316 biolink:NamedThing 3-isopropylmalate dehydratase complex A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. got7fsn_ti isopropylmalate isomerase complex See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'. MetaCyc:3-ISOPROPYLMALISOM-CPLX cellular_component owl:Class
GO:0046596 biolink:NamedThing regulation of viral entry into host cell Any process that modulates the frequency, rate or extent of the viral entry into the host cell. got7fsn_ti regulation of viral penetration into host cell|viral escort protein biological_process owl:Class
GO:0039527 biolink:NamedThing suppression by virus of host TRAF-mediated signal transduction Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of TRAF-mediated signal transduction in the host. got7fsn_ti negative regulation by virus of host TRAF-mediated signal transduction|inhibition of host TRAF-mediated signal transduction by virus|suppression by virus of host tumor necrosis factor receptor-associated factor signaling bf 2011-06-22T05:30:41Z biological_process owl:Class
GO:1905690 biolink:NamedThing nucleus disassembly The disaggregation of a nucleus into its constituent components. got7fsn_ti cell nucleus disassembly pr 2016-11-14T13:38:57Z biological_process owl:Class
GO:1900146 biolink:NamedThing negative regulation of nodal signaling pathway involved in determination of left/right asymmetry Any process that stops, prevents or reduces the frequency, rate or extent of a nodal signaling pathway, where the nodal signaling pathway is involved in determination of left/right asymmetry. got7fsn_ti downregulation of nodal signaling pathway involved in determination of left/right asymmetry|down-regulation of nodal signaling pathway involved in determination of left/right asymmetry|inhibition of nodal signaling pathway involved in determination of left/right asymmetry|negative regulation of nodal signalling pathway involved in determination of left/right asymmetry|down regulation of nodal signaling pathway involved in determination of left/right asymmetry bf 2012-03-06T11:00:36Z biological_process owl:Class
GO:0045025 biolink:NamedThing mitochondrial degradosome A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer. got7fsn_ti mtEXO cellular_component owl:Class
CL:0000148 biolink:NamedThing got7fsn_ti owl:Class
GO:0051461 biolink:NamedThing positive regulation of corticotropin secretion Any process that activates or increases the frequency, rate or extent of the regulated release of corticotropin hormone from a cell. got7fsn_ti positive regulation of corticotropic hormone secretion|up-regulation of adrenocorticotropin secretion|upregulation of adrenocorticotropin secretion|positive regulation of adrenocorticotropin secretion|positive regulation of adrenotropin secretion|stimulation of adrenocorticotropin secretion|positive regulation of ACTH secretion|positive regulation of adrenocorticotropic hormone secretion|positive regulation of adrenotropic hormone secretion|activation of adrenocorticotropin secretion|up regulation of adrenocorticotropin secretion biological_process owl:Class
GO:0046807 biolink:NamedThing viral scaffold assembly and maintenance The assembly and maintenance of the viral scaffold around which the viral capsid is constructed. got7fsn_ti See also the cellular component term 'viral scaffold ; GO:0046806'. biological_process owl:Class
GO:0045472 biolink:NamedThing response to ether Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus. got7fsn_ti biological_process owl:Class
GO:0032052 biolink:NamedThing bile acid binding Binding to a bile acid, a steroid carboxylic acids occurring in bile. got7fsn_ti molecular_function owl:Class
GO:0005354 biolink:NamedThing galactose transmembrane transporter activity Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. got7fsn_ti galactose/glucose (methylgalactoside) porter activity molecular_function owl:Class
GO:0015757 biolink:NamedThing galactose transmembrane transport The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. got7fsn_ti galactose transport biological_process owl:Class
GO:0070074 biolink:NamedThing mononeme A secretory organelle that forms part of the apical complex; a small, threadlike structure located is close proximity to the subpellicular microtubules. Its contents include a rhomboid protease (PfROM1 in Plasmodium falciparum) that moves from the lateral asymmetric localization to the merozoite apical pole and the posterior pole upon release of merozoites from schizonts. got7fsn_ti cellular_component owl:Class
GO:0071370 biolink:NamedThing cellular response to gibberellin stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus. got7fsn_ti cellular response to gibberellic acid stimulus mah 2009-12-11T03:14:21Z biological_process owl:Class
GO:0021649 biolink:NamedThing vestibulocochlear nerve structural organization The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. got7fsn_ti CN VII structural organization|vestibulocochlear nerve structural organisation biological_process owl:Class
GO:0033601 biolink:NamedThing positive regulation of mammary gland epithelial cell proliferation Any process that activates or increases the rate or extent of mammary gland epithelial cell proliferation. got7fsn_ti stimulation of mammary gland epithelial cell proliferation|upregulation of mammary gland epithelial cell proliferation|activation of mammary gland epithelial cell proliferation|up regulation of mammary gland epithelial cell proliferation|up-regulation of mammary gland epithelial cell proliferation biological_process owl:Class
GO:1900272 biolink:NamedThing negative regulation of long-term synaptic potentiation Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation. got7fsn_ti down regulation of long-term potentiation|down regulation of long-term synaptic potentiation|negative regulation of LTP|inhibition of long-term synaptic potentiation|down-regulation of long-term potentiation|inhibition of long-term potentiation|down regulation of LTP|down-regulation of LTP|negative regulation of long-term potentiation|inhibition of LTP|down-regulation of long-term synaptic potentiation|downregulation of long-term potentiation|downregulation of long-term synaptic potentiation|downregulation of LTP rl 2012-04-04T07:17:21Z biological_process owl:Class
GO:0002627 biolink:NamedThing positive regulation of T cell antigen processing and presentation Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation. got7fsn_ti stimulation of T cell antigen processing and presentation|positive regulation of T lymphocyte antigen processing and presentation|upregulation of T cell antigen processing and presentation|positive regulation of T-lymphocyte antigen processing and presentation|up regulation of T cell antigen processing and presentation|up-regulation of T cell antigen processing and presentation|positive regulation of T-cell antigen processing and presentation|activation of T cell antigen processing and presentation biological_process owl:Class
GO:1901550 biolink:NamedThing regulation of endothelial cell development Any process that modulates the frequency, rate or extent of endothelial cell development. got7fsn_ti pr 2012-10-30T12:59:50Z biological_process owl:Class
GO:1905818 biolink:NamedThing regulation of chromosome separation Any process that modulates the frequency, rate or extent of chromosome separation. got7fsn_ti regulation of rDNA separation|regulation of chromatid release bhm 2017-01-13T13:55:18Z biological_process owl:Class
GO:1900244 biolink:NamedThing positive regulation of synaptic vesicle endocytosis Any process that activates or increases the frequency, rate or extent of synaptic vesicle endocytosis. got7fsn_ti activation of synaptic vesicle endocytosis|upregulation of synaptic vesicle endocytosis|up-regulation of synaptic vesicle retrieval|positive regulation of synaptic vesicle retrieval|up-regulation of synaptic vesicle endocytosis|upregulation of synaptic vesicle retrieval|up regulation of synaptic vesicle endocytosis|up regulation of synaptic vesicle retrieval|activation of synaptic vesicle retrieval rl 2012-03-28T01:40:44Z biological_process owl:Class
GO:0003337 biolink:NamedThing mesenchymal to epithelial transition involved in metanephros morphogenesis A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros. got7fsn_ti metanephric mesenchyme to epithelial transition dph 2009-11-24T09:29:49Z biological_process owl:Class
GO:0001731 biolink:NamedThing formation of translation preinitiation complex The joining of the small ribosomal subunit, ternary complex, and mRNA. got7fsn_ti formation of translation pre-initiation complex|translation preinitiation complex assembly See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children. biological_process owl:Class
GO:0071791 biolink:NamedThing chemokine (C-C motif) ligand 5 binding Binding to chemokine (C-C motif) ligand 5. got7fsn_ti Regulated upon Activation, Normal T-cell Expressed, and Secreted binding|CCL5 binding|RANTES binding mah 2010-09-01T02:28:22Z molecular_function owl:Class
GO:0015131 biolink:NamedThing oxaloacetate transmembrane transporter activity Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:1902356 biolink:NamedThing oxaloacetate(2-) transmembrane transport The directed movement of oxaloacetate(2-) across a membrane. got7fsn_ti dph 2013-08-14T14:40:37Z biological_process owl:Class
GO:0001621 biolink:NamedThing G protein-coupled ADP receptor activity Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. got7fsn_ti platelet ADP receptor activity|ADP-activated adenosine receptor activity|ADP receptor activity|K101 receptor|ADP-activated nucleotide receptor activity GO:0045032 molecular_function owl:Class
GO:0043531 biolink:NamedThing ADP binding Binding to ADP, adenosine 5'-diphosphate. got7fsn_ti adenosine 5'-diphosphate binding|adenosine diphosphate binding molecular_function owl:Class
GO:0070235 biolink:NamedThing regulation of activation-induced cell death of T cells Any process that modulates the occurrence or rate of activation-induced cell death of T cells. got7fsn_ti regulation of activation-induced cell death of T lymphocytes|regulation of activated T cell apoptosis|regulation of activation-induced cell death of T-lymphocytes|regulation of AICD|regulation of activation-induced cell death of T-cells|regulation of antigen-driven apoptosis biological_process owl:Class
GO:0042673 biolink:NamedThing regulation of retinal cone cell fate specification Any process that mediates the specification of a cell into a retinal cone cell. got7fsn_ti biological_process owl:Class
GO:0022898 biolink:NamedThing regulation of transmembrane transporter activity Any process that modulates the frequency, rate or extent of transmembrane transporter activity. got7fsn_ti biological_process owl:Class
GO:1902962 biolink:NamedThing regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process Any process that modulates the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process. got7fsn_ti regulation of metalloendoprotease activity involved in APP catabolism|regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process|regulation of metalloendoprotease activity involved in amyloid precursor protein degradation|regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolism|regulation of metalloendoproteinase activity involved in amyloid precursor protein breakdown|regulation of metalloendoproteinase activity involved in APP catabolism|regulation of metalloendoprotease activity involved in APP catabolic process|regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolism|regulation of metalloendopeptidase activity involved in APP catabolism|regulation of metalloendoproteinase activity involved in amyloid precursor protein degradation|regulation of metalloendopeptidase activity involved in amyloid precursor protein breakdown|regulation of metalloendoproteinase activity involved in APP catabolic process|regulation of metalloendoprotease activity involved in amyloid precursor protein catabolic process|regulation of metalloendoprotease activity involved in amyloid precursor protein catabolism|regulation of metalloendopeptidase activity involved in amyloid precursor protein degradation|regulation of metalloendoprotease activity involved in amyloid precursor protein breakdown|regulation of metalloendopeptidase activity involved in APP catabolic process sjp 2014-05-06T09:11:55Z biological_process owl:Class
GO:0097166 biolink:NamedThing lens epithelial cell proliferation The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth. got7fsn_ti pr 2011-09-29T01:27:50Z biological_process owl:Class
GO:1903473 biolink:NamedThing positive regulation of mitotic actomyosin contractile ring contraction Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction. got7fsn_ti activation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|upregulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|up-regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|positive regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|activation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|positive regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|up-regulation of mitotic actomyosin contractile ring contraction|upregulation of mitotic actomyosin contractile ring contraction|up regulation of cytokinesis, actomyosin ring contraction involved in mitotic cell cycle|up-regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|activation of mitotic actomyosin contractile ring contraction|up regulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle|positive regulation of mitotic actomyosin contractile ring constriction|up regulation of mitotic actomyosin contractile ring contraction|upregulation of contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle https://github.com/geneontology/go-ontology/issues/21855 vw 2014-09-23T14:10:46Z biological_process owl:Class
GO:0098853 biolink:NamedThing endoplasmic reticulum-vacuole membrane contact site A zone of apposition between endoplasmic-reticulum and lytic vacuole membranes, structured by bridging complexes. got7fsn_ti ER-vacuole membrane contact site|endoplasmic reticulum-vacuole membrane contact site cellular_component owl:Class
GO:0106089 biolink:NamedThing negative regulation of cell adhesion involved in sprouting angiogenesis Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion involved in sprouting angiogenesis. got7fsn_ti hjd 2018-01-22T18:28:08Z biological_process owl:Class
GO:0015530 biolink:NamedThing shikimate transmembrane transporter activity Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids. got7fsn_ti molecular_function owl:Class
GO:0015733 biolink:NamedThing shikimate transmembrane transport The process in which shikimate is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti shikimate transport biological_process owl:Class
PO:0009074 biolink:NamedThing got7fsn_ti owl:Class
GO:0061179 biolink:NamedThing negative regulation of insulin secretion involved in cellular response to glucose stimulus Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. got7fsn_ti negative regulation of insulin secretion in response to glucose|negative regulation of insulin secretion involved in cellular response to glucose dph 2010-07-13T09:41:46Z biological_process owl:Class
GO:0005458 biolink:NamedThing GDP-mannose transmembrane transporter activity Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate. got7fsn_ti molecular_function owl:Class
GO:1990570 biolink:NamedThing GDP-mannose transmembrane transport The process in which GDP-mannose is transported across a membrane. got7fsn_ti GDP-mannose transport vw 2014-11-27T12:05:09Z GO:0015784 biological_process owl:Class
GO:0010058 biolink:NamedThing regulation of atrichoblast fate specification Any process that modulates atrichoblast fate specification. got7fsn_ti biological_process owl:Class
GO:0003190 biolink:NamedThing atrioventricular valve formation The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. got7fsn_ti AV valve formation dph 2009-10-08T01:07:28Z biological_process owl:Class
GO:1902908 biolink:NamedThing regulation of melanosome transport Any process that modulates the frequency, rate or extent of melanosome transport. got7fsn_ti als 2014-04-17T11:40:16Z biological_process owl:Class
GO:0032253 biolink:NamedThing dense core granule localization Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti dense core granule clustering|dense core vesicle localization|dense core granule localisation biological_process owl:Class
GO:0060047 biolink:NamedThing heart contraction The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body. got7fsn_ti cardiac contraction|hemolymph circulation|heart beating biological_process owl:Class
GO:0002353 biolink:NamedThing plasma kallikrein-kinin cascade A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. got7fsn_ti biological_process owl:Class
GO:0035619 biolink:NamedThing root hair tip The tip portion of an outgrowth of a root epidermal cell. got7fsn_ti root hair cell tip bf 2010-12-03T01:43:55Z cellular_component owl:Class
GO:1905294 biolink:NamedThing positive regulation of neural crest cell differentiation Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation. got7fsn_ti up regulation of neural crest cell differentiation|upregulation of neural crest cell differentiation|activation of neural crest cell differentiation|up-regulation of neural crest cell differentiation rl 2016-06-28T15:02:16Z biological_process owl:Class
GO:0042656 biolink:NamedThing JUN kinase kinase kinase kinase activity Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs). got7fsn_ti JUNKKKK activity molecular_function owl:Class
GO:0072349 biolink:NamedThing modified amino acid transmembrane transporter activity Enables the transfer of modified amino acids from one side of a membrane to the other. got7fsn_ti amino acid derivative transmembrane transporter activity|modified amino acid transporter activity mah 2010-11-11T11:50:31Z molecular_function owl:Class
GO:0072337 biolink:NamedThing modified amino acid transport The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti amino acid derivative transport mah 2010-11-04T12:18:23Z biological_process owl:Class
GO:1900486 biolink:NamedThing positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway Any process that activates or increases the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. got7fsn_ti activation of isopentenyl diphosphate biosynthetic process, mevalonate pathway|activation of isopentenyl diphosphate anabolism, mevalonate pathway|upregulation of acetate-mevalonate pathway|activation of acetate-mevalonate pathway|up regulation of Ac-MVA pathway|positive regulation of isopentenyl diphosphate synthesis, mevalonate pathway|positive regulation of isopentenyl diphosphate anabolism, mevalonate pathway|upregulation of isopentenyl diphosphate synthesis, mevalonate pathway|up-regulation of isopentenyl diphosphate synthesis, mevalonate pathway|up-regulation of acetate-mevalonate pathway|activation of isopentenyl diphosphate synthesis, mevalonate pathway|up-regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway|upregulation of isopentenyl diphosphate anabolism, mevalonate pathway|positive regulation of isopentenyl diphosphate formation, mevalonate pathway|up regulation of isopentenyl diphosphate formation, mevalonate pathway|up-regulation of isopentenyl diphosphate anabolism, mevalonate pathway|activation of Ac-MVA pathway|up regulation of isopentenyl diphosphate synthesis, mevalonate pathway|upregulation of isopentenyl diphosphate formation, mevalonate pathway|activation of isopentenyl diphosphate formation, mevalonate pathway|positive regulation of acetate-mevalonate pathway|up regulation of acetate-mevalonate pathway|up regulation of isopentenyl diphosphate anabolism, mevalonate pathway|upregulation of Ac-MVA pathway|upregulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway|up-regulation of Ac-MVA pathway|positive regulation of Ac-MVA pathway|up regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway|up-regulation of isopentenyl diphosphate formation, mevalonate pathway al 2012-05-02T10:46:46Z biological_process owl:Class
GO:0097590 biolink:NamedThing archaeal-type flagellum-dependent cell motility Cell motility due to the motion of one or more archaeal-type flagella. An archaeal-type flagellum (also called archaellum) is a non-membrane-bounded organelle superficially similar to a bacterial-type flagellum, but having a different molecular structure and lacking a central channel. got7fsn_ti archaeal-type flagellar cell motility pr 2014-03-25T20:40:50Z biological_process owl:Class
GO:0031954 biolink:NamedThing positive regulation of protein autophosphorylation Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues. got7fsn_ti positive regulation of protein amino acid autophosphorylation|stimulation of protein amino acid autophosphorylation|upregulation of protein amino acid autophosphorylation|activation of protein amino acid autophosphorylation|up regulation of protein amino acid autophosphorylation|up-regulation of protein amino acid autophosphorylation biological_process owl:Class
GO:1903397 biolink:NamedThing positive regulation of secondary cell septum biogenesis Any process that activates or increases the frequency, rate or extent of secondary cell septum biogenesis. got7fsn_ti up regulation of secondary cell septum biogenesis|up-regulation of secondary cell septum biogenesis|upregulation of secondary cell septum biogenesis|activation of secondary cell septum biogenesis di 2014-08-29T21:42:34Z biological_process owl:Class
GO:0120200 biolink:NamedThing rod photoreceptor outer segment The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins. got7fsn_ti krc 2019-05-07T22:47:20Z cellular_component owl:Class
GO:2000480 biolink:NamedThing negative regulation of cAMP-dependent protein kinase activity Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity. got7fsn_ti negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity|negative regulation of AMPK|negative regulation of protein kinase A activity|negative regulation of PKA C|negative regulation of cyclic AMP-dependent protein kinase activity|negative regulation of cAMP-dependent protein kinase, intrinsic catalyst activity|negative regulation of STK22|negative regulation of 3',5'-cAMP-dependent protein kinase activity|negative regulation of PKA|negative regulation of 3',5' cAMP-dependent protein kinase activity|negative regulation of ATP:protein phosphotransferase (cAMP-dependent) activity yaf 2011-03-10T11:13:45Z biological_process owl:Class
GO:0042314 biolink:NamedThing bacteriochlorophyll binding Binding to bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants. got7fsn_ti molecular_function owl:Class
GO:1904324 biolink:NamedThing negative regulation of inhibitory G protein-coupled receptor phosphorylation Any process that stops, prevents or reduces the frequency, rate or extent of inhibitory G protein-coupled receptor phosphorylation. got7fsn_ti negative regulation of inhibitory G-protein coupled receptor phosphorylation|down regulation of inhibitory G-protein coupled receptor phosphorylation|inhibition of inhibitory G-protein coupled receptor phosphorylation|downregulation of inhibitory G-protein coupled receptor phosphorylation|down-regulation of inhibitory G-protein coupled receptor phosphorylation sl 2015-06-10T19:46:43Z biological_process owl:Class
GO:0042947 biolink:NamedThing glucoside transmembrane transporter activity Enables the transfer of glucosides from one side of a membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue. got7fsn_ti molecular_function owl:Class
GO:0042946 biolink:NamedThing glucoside transport The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue. got7fsn_ti biological_process owl:Class
GO:0005851 biolink:NamedThing eukaryotic translation initiation factor 2B complex A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. got7fsn_ti eIF-2B|eif2B cellular_component owl:Class
GO:1990573 biolink:NamedThing potassium ion import across plasma membrane The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti potassium import|potassium ion uptake|potassium ion import vw 2014-12-04T09:48:12Z GO:0010107 biological_process owl:Class
GO:0001676 biolink:NamedThing long-chain fatty acid metabolic process The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. got7fsn_ti long-chain fatty acid metabolism biological_process owl:Class
GO:0010922 biolink:NamedThing positive regulation of phosphatase activity Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. got7fsn_ti biological_process owl:Class
GO:0044166 biolink:NamedThing host cell endoplasmic reticulum lumen The volume enclosed by the membranes of the host cell endoplasmic reticulum. got7fsn_ti host endoplasmic reticulum lumen jl 2009-09-04T11:13:30Z cellular_component owl:Class
GO:0062177 biolink:NamedThing radial spoke assembly The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. got7fsn_ti dph 2019-11-20T17:50:08Z biological_process owl:Class
GO:0005274 biolink:NamedThing allantoin:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport. got7fsn_ti allantoin uptake transmembrane transporter activity|allantoin/allantoate transporter|allantoin permease activity GO:0015206 molecular_function owl:Class
GO:0015720 biolink:NamedThing allantoin transport The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti allantoin/allantoate transport|allantoin transmembrane transport biological_process owl:Class
GO:0003333 biolink:NamedThing amino acid transmembrane transport The process in which an amino acid is transported across a membrane. got7fsn_ti amino acid membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. dph 2009-11-02T02:36:11Z biological_process owl:Class
GO:0001536 biolink:NamedThing radial spoke stalk Globular portion of the radial spoke that projects towards the central pair of microtubules. got7fsn_ti cellular_component owl:Class
GO:1902981 biolink:NamedThing synthesis of RNA primer involved in mitotic DNA replication Any synthesis of RNA primer involved in mitotic cell cycle DNA replication. got7fsn_ti synthesis of RNA primer involved in mitotic cell cycle DNA replication jl 2014-05-06T19:20:00Z GO:1903458 biological_process owl:Class
GO:1902557 biolink:NamedThing 5'-adenylyl sulfate transmembrane transporter activity Enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other. got7fsn_ti An example of this is the YPR011C gene product in S. cerevisiae in PMID:24296033. mcc 2013-12-09T23:08:05Z molecular_function owl:Class
GO:1902558 biolink:NamedThing 5'-adenylyl sulfate transmembrane transport The process in which 5'-adenylyl sulfate is transported across a membrane. got7fsn_ti adenosine 5'-phosphosulfate transmembrane transport mcc 2013-12-09T23:16:01Z biological_process owl:Class
GO:0019977 biolink:NamedThing interleukin-21 binding Binding to interleukin-21. got7fsn_ti IL-21 binding molecular_function owl:Class
GO:1901397 biolink:NamedThing positive regulation of transforming growth factor beta2 activation Any process that activates or increases the frequency, rate or extent of transforming growth factor beta2 activation. got7fsn_ti upregulation of TGFB2 activation|positive regulation of TGF-beta 2 activation|up regulation of TGFB2 activation|up-regulation of TGFbeta 2 activation|activation of transforming growth factor beta2 activation|positive regulation of TGFB2 activation|up regulation of transforming growth factor beta2 activation|up regulation of TGFbeta 2 activation|upregulation of transforming growth factor beta2 activation|positive regulation of TGFbeta 2 activation|up regulation of TGF-beta 2 activation|up-regulation of transforming growth factor beta2 activation|upregulation of TGF-beta 2 activation|upregulation of TGFbeta 2 activation|activation of TGF-beta 2 activation|up-regulation of TGFB2 activation|up-regulation of TGF-beta 2 activation|activation of TGFbeta 2 activation|activation of TGFB2 activation bf 2012-10-01T10:48:15Z biological_process owl:Class
GO:0034089 biolink:NamedThing establishment of meiotic sister chromatid cohesion The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle. got7fsn_ti biological_process owl:Class
GO:0070129 biolink:NamedThing regulation of mitochondrial translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. got7fsn_ti regulation of mitochondrial protein synthesis|regulation of mitochondrial protein formation|regulation of mitochondrial protein biosynthesis|regulation of mitochondrial protein anabolism biological_process owl:Class
GO:0010522 biolink:NamedThing regulation of calcium ion transport into cytosol Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components. got7fsn_ti biological_process owl:Class
GO:0002809 biolink:NamedThing negative regulation of antibacterial peptide biosynthetic process Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis. got7fsn_ti down-regulation of antibacterial peptide biosynthetic process|downregulation of antibacterial peptide biosynthetic process|inhibition of antibacterial peptide biosynthetic process|down regulation of antibacterial peptide biosynthetic process biological_process owl:Class
GO:0045069 biolink:NamedThing regulation of viral genome replication Any process that modulates the frequency, rate or extent of viral genome replication. got7fsn_ti biological_process owl:Class
GO:1905447 biolink:NamedThing negative regulation of mitochondrial ATP synthesis coupled electron transport Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial ATP synthesis coupled electron transport. got7fsn_ti inhibition of mitochondrial ATP synthesis coupled electron transport|downregulation of mitochondrial ATP synthesis coupled electron transport|down regulation of mitochondrial ATP synthesis coupled electron transport|down-regulation of mitochondrial ATP synthesis coupled electron transport dph 2016-09-15T18:58:06Z biological_process owl:Class
GO:0010809 biolink:NamedThing negative regulation of synaptic vesicle priming Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. got7fsn_ti biological_process owl:Class
GO:0000918 biolink:NamedThing division septum site selection The process of marking the site where a division septum will form. got7fsn_ti septin assembly and septum biosynthesis|septin assembly and septum formation|septum positioning|selection of site for division septum formation|selection of site for barrier cell septum biosynthesis|selection of site for barrier cell septum formation biological_process owl:Class
GO:0060506 biolink:NamedThing smoothened signaling pathway involved in lung development The series of molecular signals generated as a consequence of activation of the transmembrane Smoothened-type protein. This process contributes to lung development. got7fsn_ti hh signaling pathway involved in lung development|hedgehog signaling pathway involved in lung development|smoothened signalling pathway involved in lung development biological_process owl:Class
GO:0048209 biolink:NamedThing regulation of vesicle targeting, to, from or within Golgi Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus. got7fsn_ti regulation of Golgi vesicle targeting biological_process owl:Class
GO:0043709 biolink:NamedThing cell adhesion involved in single-species biofilm formation The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. got7fsn_ti cell adhesion during single-species biofilm formation biological_process owl:Class
GO:0003216 biolink:NamedThing cardiac left atrium formation The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts. got7fsn_ti dph 2009-10-13T09:52:31Z biological_process owl:Class
GO:0003212 biolink:NamedThing cardiac left atrium morphogenesis The process in which the left cardiac atrium is generated and organized. got7fsn_ti dph 2009-10-13T09:48:16Z biological_process owl:Class
GO:0034986 biolink:NamedThing iron chaperone activity Directly binding to and delivering iron ions to a target protein. got7fsn_ti molecular_function owl:Class
GO:0005506 biolink:NamedThing iron ion binding Binding to an iron (Fe) ion. got7fsn_ti iron binding molecular_function owl:Class
GO:1904456 biolink:NamedThing negative regulation of neuronal action potential Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential. got7fsn_ti down-regulation of neuronal action potential|downregulation of neuronal action potential|negative regulation of generation of action potential|inhibition of neuronal action potential|down regulation of generation of action potential|inhibition of generation of action potential|downregulation of generation of action potential|down-regulation of generation of action potential|down regulation of neuronal action potential sl 2015-07-09T18:02:40Z biological_process owl:Class
GO:0030510 biolink:NamedThing regulation of BMP signaling pathway Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway. got7fsn_ti regulation of BMP receptor signaling pathway|regulation of bone morphogenetic protein signaling pathway|regulation of BMP signalling pathway|regulation of decapentaplegic receptor signaling pathway|regulation of bone morphogenetic protein signalling pathway|regulation of decapentaplegic signaling pathway|regulation of decapentaplegic receptor signalling pathway tb 2009-11-13T10:49:14Z GO:0090097 biological_process owl:Class
GO:0031096 biolink:NamedThing platelet dense tubular network lumen The volume enclosed by the membranes of the platelet dense tubular network. got7fsn_ti cellular_component owl:Class
GO:2000730 biolink:NamedThing regulation of termination of RNA polymerase I transcription Any process that modulates the frequency, rate or extent of termination of RNA polymerase I transcription. got7fsn_ti regulation of transcription termination from RNA polymerase I promoter|regulation of RNA polymerase I transcription termination|regulation of transcription termination from Pol I promoter dph 2011-06-10T08:43:39Z biological_process owl:Class
GO:0061511 biolink:NamedThing centriole elongation The centrosome organization process by which a centriole increases in length as part of the process of replication. got7fsn_ti dph 2013-03-22T09:06:27Z biological_process owl:Class
GO:0003372 biolink:NamedThing establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell. got7fsn_ti dph 2009-12-08T05:46:23Z biological_process owl:Class
GO:0003369 biolink:NamedThing establishment of cell polarity involved in mesendodermal cell migration The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell. got7fsn_ti dph 2009-12-08T05:31:51Z biological_process owl:Class
GO:0001761 biolink:NamedThing beta-alanine transmembrane transporter activity Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid. got7fsn_ti beta-alanine transporter activity molecular_function owl:Class
GO:0099108 biolink:NamedThing potassium channel activator activity involved in G protein-coupled receptor signaling pathway Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling. got7fsn_ti potassium channel activator activity involved in G-protein coupled receptor signaling pathway Examples include G-protein beta-gamma complexes that bind to and activate potassium channels. molecular_function owl:Class
GO:0099109 biolink:NamedThing potassium channel activating, G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds activation of a potassium ion channel. got7fsn_ti potassium channel activating, G-protein coupled receptor signaling pathway biological_process owl:Class
GO:0031147 biolink:NamedThing 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells. got7fsn_ti 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism|DIF-1 metabolic process|DIF-1 metabolism biological_process owl:Class
GO:1902760 biolink:NamedThing Mo(VI)-molybdopterin cytosine dinucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of Mo(VI)-molybdopterin cytosine dinucleotide. got7fsn_ti Mo(VI)-molybdopterin cytosine dinucleotide biosynthesis|Mo(VI)-molybdopterin cytosine dinucleotide anabolism|Mo(VI)-molybdopterin cytosine dinucleotide formation|Mo(VI)-molybdopterin cytosine dinucleotide synthesis|Mo-molybdopterin-cytosine-dinucleotide cofactor biosynthetic process dph 2014-03-06T14:00:43Z GO:0061601 MetaCyc:PWY-6476 biological_process owl:Class
GO:0042911 biolink:NamedThing acridine transmembrane transporter activity Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene from one side of a membrane to the other. got7fsn_ti acridine transporter activity molecular_function owl:Class
GO:0042909 biolink:NamedThing acridine transport The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1905284 biolink:NamedThing positive regulation of epidermal growth factor receptor signaling pathway involved in heart process Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway involved in heart process. got7fsn_ti upregulation of EGF receptor signaling pathway involved in heart process|up-regulation of EGF receptor signaling pathway involved in heart process|up regulation of EGF receptor signalling pathway involved in heart process|upregulation of epidermal growth factor receptor signaling pathway involved in cardiac process|positive regulation of EGF receptor signalling pathway involved in heart process|upregulation of epidermal growth factor receptor signaling pathway involved in heart process|up regulation of EGF receptor signaling pathway involved in heart process|up regulation of EGF receptor signalling pathway involved in cardiac process|upregulation of ERBB1 signaling pathway involved in cardiac process|up-regulation of ERBB1 signaling pathway involved in cardiac process|positive regulation of EGFR signaling pathway involved in cardiac process|positive regulation of EGF receptor signaling pathway involved in heart process|positive regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|positive regulation of ERBB1 signaling pathway involved in cardiac process|upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|positive regulation of EGF receptor signalling pathway involved in cardiac process|activation of EGF receptor signalling pathway involved in cardiac process|upregulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|positive regulation of EGF receptor signaling pathway involved in cardiac process|activation of EGFR signaling pathway involved in cardiac process|up-regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|activation of epidermal growth factor receptor signaling pathway involved in cardiac process|activation of ERBB1 signaling pathway involved in cardiac process|up-regulation of ERBB1 signaling pathway involved in heart process|activation of epidermal growth factor receptor signalling pathway involved in heart process|activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|up-regulation of EGF receptor signaling pathway involved in cardiac process|up regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|up regulation of epidermal growth factor receptor signalling pathway involved in heart process|up regulation of ERBB1 signaling pathway involved in cardiac process|up-regulation of epidermal growth factor receptor signalling pathway involved in heart process|up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|positive regulation of epidermal growth factor receptor signalling pathway involved in heart process|up regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|activation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in cardiac process|up-regulation of EGF receptor signalling pathway involved in heart process|upregulation of epidermal growth factor receptor signalling pathway involved in heart process|up-regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|upregulation of EGF receptor signalling pathway involved in heart process|upregulation of ERBB1 signaling pathway involved in heart process|activation of ERBB1 signaling pathway involved in heart process|up regulation of epidermal growth factor receptor signaling pathway involved in heart process|up regulation of EGFR signaling pathway involved in heart process|upregulation of EGF receptor signaling pathway involved in cardiac process|activation of EGF receptor signalling pathway involved in heart process|upregulation of EGF receptor signalling pathway involved in cardiac process|positive regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|upregulation of EGFR signaling pathway involved in cardiac process|up-regulation of epidermal growth factor receptor signalling pathway involved in cardiac process|activation of EGFR signaling pathway involved in heart process|up-regulation of EGFR signaling pathway involved in heart process|upregulation of EGFR signaling pathway involved in heart process|activation of epidermal growth factor receptor signaling pathway involved in heart process|up-regulation of EGF receptor signalling pathway involved in cardiac process|positive regulation of EGFR signaling pathway involved in heart process|activation of EGF receptor signaling pathway involved in cardiac process|positive regulation of receptor tyrosine-protein kinase erbB-1 signaling pathway involved in heart process|up regulation of ERBB1 signaling pathway involved in heart process|up-regulation of EGFR signaling pathway involved in cardiac process|up regulation of epidermal growth factor receptor signaling pathway involved in cardiac process|up regulation of EGFR signaling pathway involved in cardiac process|up regulation of EGF receptor signaling pathway involved in cardiac process|up-regulation of epidermal growth factor receptor signaling pathway involved in heart process|positive regulation of ERBB1 signaling pathway involved in heart process|activation of EGF receptor signaling pathway involved in heart process|upregulation of epidermal growth factor receptor signalling pathway involved in cardiac process|activation of epidermal growth factor receptor signalling pathway involved in cardiac process bc 2016-06-20T14:40:57Z biological_process owl:Class
GO:0070130 biolink:NamedThing negative regulation of mitochondrial translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion. got7fsn_ti negative regulation of mitochondrial protein synthesis|negative regulation of mitochondrial protein biosynthesis|negative regulation of mitochondrial protein anabolism|negative regulation of mitochondrial protein formation biological_process owl:Class
GO:0110160 biolink:NamedThing negative regulation of mitotic spindle formation (spindle phase one) Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one). got7fsn_ti kmv 2019-08-12T15:18:32Z biological_process owl:Class
GO:0046610 biolink:NamedThing lysosomal proton-transporting V-type ATPase, V0 domain The V0 domain of a proton-transporting V-type ATPase found in the lysosomal membrane. got7fsn_ti lysosomal hydrogen ion-transporting ATPase V0 domain cellular_component owl:Class
GO:0061763 biolink:NamedThing multivesicular body-lysosome fusion The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle. got7fsn_ti MVB-lysosome fusion|fusion of MVB to lysosome|fusion of multivesicular body to lysosome dph 2016-04-15T07:12:40Z biological_process owl:Class
GO:0005946 biolink:NamedThing alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present. got7fsn_ti UDP-glucose-glucosephosphate glucosyltransferase complex|trehalose-6-phosphate synthase/phosphatase|trehalose-6-phosphate synthase complex See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'. cellular_component owl:Class
GO:2000236 biolink:NamedThing negative regulation of tRNA processing Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing. got7fsn_ti negative regulation of tRNA maturation mah 2010-11-10T12:15:13Z biological_process owl:Class
GO:1904343 biolink:NamedThing positive regulation of colon smooth muscle contraction Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction. got7fsn_ti activation of colon smooth muscle contraction|up-regulation of colon smooth muscle contraction|upregulation of colon smooth muscle contraction|up regulation of colon smooth muscle contraction sl 2015-06-11T21:17:11Z biological_process owl:Class
GO:0006094 biolink:NamedThing gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. got7fsn_ti glucose biosynthetic process|glucose biosynthesis Wikipedia:Gluconeogenesis|MetaCyc:GLUCONEO-PWY biological_process owl:Class
GO:0000332 biolink:NamedThing template for synthesis of G-rich strand of telomere DNA activity Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA. got7fsn_ti telomerase RNA|telomerase, template Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. molecular_function owl:Class
GO:0062123 biolink:NamedThing regulation of linear element maturation Any process that modulates the rate, frequency or extent of linear element maturation. got7fsn_ti dph 2019-04-23T13:36:20Z biological_process owl:Class
GO:0051034 biolink:NamedThing tRNA transmembrane transporter activity Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:1902188 biolink:NamedThing positive regulation of viral release from host cell Any process that activates or increases the frequency, rate or extent of viral release from host cell. got7fsn_ti up-regulation of viral shedding|positive regulation of release of virus from host|up-regulation of viral release|upregulation of viral release|positive regulation of viral release|up regulation of viral shedding|activation of viral exit|up regulation of viral release from host cell|positive regulation of viral exit|up-regulation of release of virus from host|upregulation of release of virus from host|up-regulation of viral exit|upregulation of viral shedding|activation of viral shedding|upregulation of viral exit|up regulation of viral exit|up-regulation of viral release from host cell|activation of viral release|activation of viral release from host cell|upregulation of viral release from host cell|activation of release of virus from host|positive regulation of viral shedding|up regulation of release of virus from host|up regulation of viral release ss 2013-06-04T03:54:14Z biological_process owl:Class
GO:1900263 biolink:NamedThing negative regulation of DNA-directed DNA polymerase activity Any process that stops, prevents or reduces the frequency, rate or extent of DNA-directed DNA polymerase activity. got7fsn_ti downregulation of epsilon DNA polymerase activity|down-regulation of Klenow fragment|inhibition of sequenase|down regulation of DNA polymerase alpha|down regulation of Taq Pol I|down regulation of deoxyribonucleic duplicase activity|down regulation of DNA-dependent DNA polymerase activity|down regulation of zeta DNA polymerase activity|down regulation of epsilon DNA polymerase activity|down regulation of DNA polymerase beta|down regulation of DNA polymerase gamma|inhibition of DNA polymerase II|inhibition of DNA-dependent DNA polymerase activity|negative regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|down regulation of mu DNA polymerase activity|downregulation of beta DNA polymerase activity|negative regulation of DNA polymerase gamma|down-regulation of Tca DNA polymerase|down-regulation of theta DNA polymerase activity|inhibition of alpha DNA polymerase activity|down-regulation of sigma DNA polymerase activity|negative regulation of epsilon DNA polymerase activity|down regulation of DNA nucleotidyltransferase (DNA-directed) activity|down-regulation of DNA-directed DNA polymerase activity|downregulation of eta DNA polymerase activity|negative regulation of deoxyribonucleic polymerase I|down-regulation of alpha DNA polymerase activity|down-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|inhibition of epsilon DNA polymerase activity|inhibition of DNA polymerase I|negative regulation of sequenase|negative regulation of beta DNA polymerase activity|downregulation of sequenase|down-regulation of DNA-dependent DNA polymerase activity|down-regulation of DNA polymerase III|inhibition of delta DNA polymerase activity|negative regulation of DNA polymerase II|downregulation of DNA polymerase gamma|inhibition of deoxyribonucleic polymerase I|downregulation of mu DNA polymerase activity|negative regulation of DNA polymerase alpha|downregulation of Tca DNA polymerase|negative regulation of mu DNA polymerase activity|inhibition of nu DNA polymerase activity|inhibition of sigma DNA polymerase activity|downregulation of kappa DNA polymerase activity|down regulation of DNA replicase activity|negative regulation of theta DNA polymerase activity|inhibition of DNA polymerase V activity|downregulation of deoxyribonucleic polymerase I|down-regulation of lambda DNA polymerase activity|downregulation of theta DNA polymerase activity|down-regulation of gamma DNA-directed DNA polymerase activity|inhibition of gamma DNA-directed DNA polymerase activity|down regulation of lambda DNA polymerase activity|downregulation of DNA replicase activity|inhibition of Tca DNA polymerase|negative regulation of lambda DNA polymerase activity|down-regulation of DNA polymerase I|downregulation of DNA polymerase beta|inhibition of mu DNA polymerase activity|inhibition of DNA-directed DNA polymerase activity|negative regulation of eta DNA polymerase activity|down-regulation of DNA polymerase alpha|downregulation of zeta DNA polymerase activity|downregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|inhibition of Taq Pol I|inhibition of deoxyribonucleic acid duplicase activity|down-regulation of iota DNA polymerase activity|down regulation of theta DNA polymerase activity|down regulation of delta DNA polymerase activity|down regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|inhibition of duplicase|negative regulation of DNA polymerase beta|inhibition of eta DNA polymerase activity|down-regulation of Taq DNA polymerase|downregulation of deoxyribonucleic acid duplicase activity|down regulation of DNA polymerase V activity|negative regulation of DNA-dependent DNA polymerase activity|negative regulation of duplicase|inhibition of DNA nucleotidyltransferase (DNA-directed) activity|negative regulation of Tca DNA polymerase|inhibition of theta DNA polymerase activity|negative regulation of DNA polymerase III|down regulation of DNA polymerase II|down-regulation of DNA duplicase activity|down regulation of duplicase|down-regulation of DNA polymerase gamma|downregulation of sigma DNA polymerase activity|down regulation of DNA-directed DNA polymerase activity|negative regulation of DNA replicase activity|downregulation of alpha DNA polymerase activity|negative regulation of deoxyribonucleic duplicase activity|down regulation of gamma DNA-directed DNA polymerase activity|negative regulation of alpha DNA polymerase activity|negative regulation of delta DNA polymerase activity|downregulation of Klenow fragment|down-regulation of deoxyribonucleic duplicase activity|downregulation of DNA polymerase II|down-regulation of DNA polymerase V activity|inhibition of DNA polymerase alpha|down-regulation of delta DNA polymerase activity|down regulation of nu DNA polymerase activity|inhibition of kappa DNA polymerase activity|inhibition of DNA duplicase activity|negative regulation of DNA nucleotidyltransferase (DNA-directed) activity|down-regulation of epsilon DNA polymerase activity|negative regulation of sigma DNA polymerase activity|down regulation of DNA polymerase I|down regulation of DNA duplicase activity|inhibition of iota DNA polymerase activity|downregulation of lambda DNA polymerase activity|inhibition of lambda DNA polymerase activity|downregulation of duplicase|down regulation of Klenow fragment|inhibition of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|down-regulation of zeta DNA polymerase activity|downregulation of DNA-directed DNA polymerase activity|downregulation of DNA nucleotidyltransferase (DNA-directed) activity|negative regulation of kappa DNA polymerase activity|negative regulation of Taq DNA polymerase|inhibition of Klenow fragment|negative regulation of DNA polymerase I|negative regulation of DNA polymerase V activity|down regulation of deoxyribonucleic polymerase I|down regulation of Taq DNA polymerase|down regulation of beta DNA polymerase activity|down-regulation of duplicase|inhibition of DNA polymerase gamma|inhibition of DNA polymerase III|downregulation of nu DNA polymerase activity|downregulation of DNA polymerase V activity|downregulation of delta DNA polymerase activity|down-regulation of DNA replicase activity|downregulation of gamma DNA-directed DNA polymerase activity|down regulation of sequenase|down-regulation of eta DNA polymerase activity|down-regulation of Taq Pol I|down-regulation of kappa DNA polymerase activity|down regulation of iota DNA polymerase activity|inhibition of Taq DNA polymerase|down-regulation of deoxyribonucleic acid duplicase activity|down-regulation of mu DNA polymerase activity|down regulation of kappa DNA polymerase activity|negative regulation of gamma DNA-directed DNA polymerase activity|downregulation of Taq DNA polymerase|down-regulation of DNA polymerase beta|inhibition of DNA replicase activity|negative regulation of DNA duplicase activity|inhibition of DNA polymerase beta|downregulation of DNA polymerase I|downregulation of DNA duplicase activity|downregulation of iota DNA polymerase activity|down regulation of deoxyribonucleic acid duplicase activity|down-regulation of DNA polymerase II|negative regulation of iota DNA polymerase activity|down regulation of Tca DNA polymerase|downregulation of DNA polymerase III|down regulation of alpha DNA polymerase activity|downregulation of DNA-dependent DNA polymerase activity|downregulation of Taq Pol I|negative regulation of Klenow fragment|negative regulation of Taq Pol I|down regulation of sigma DNA polymerase activity|inhibition of zeta DNA polymerase activity|down-regulation of DNA nucleotidyltransferase (DNA-directed) activity|negative regulation of zeta DNA polymerase activity|inhibition of beta DNA polymerase activity|down regulation of DNA polymerase III|negative regulation of nu DNA polymerase activity|down regulation of eta DNA polymerase activity|negative regulation of deoxyribonucleic acid duplicase activity|downregulation of DNA polymerase alpha|downregulation of deoxyribonucleic duplicase activity|inhibition of deoxyribonucleic duplicase activity|down-regulation of beta DNA polymerase activity|down-regulation of sequenase|down-regulation of nu DNA polymerase activity|down-regulation of deoxyribonucleic polymerase I tb 2012-04-03T11:07:18Z biological_process owl:Class
GO:1900103 biolink:NamedThing positive regulation of endoplasmic reticulum unfolded protein response Any process that activates or increases the frequency, rate or extent of endoplasmic reticulum unfolded protein response. got7fsn_ti upregulation of endoplasmic reticulum unfolded protein response|up regulation of SREBP-mediated signalling pathway|up-regulation of endoplasmic reticulum unfolded protein response|up-regulation of SREBP-mediated signalling pathway|up-regulation of erUPR|upregulation of SREBP-mediated signalling pathway|positive regulation of SREBP-mediated signalling pathway|up regulation of endoplasmic reticulum unfolded protein response|positive regulation of erUPR|upregulation of ER unfolded protein response|activation of ER unfolded protein response|positive regulation of ER unfolded protein response|up-regulation of ER unfolded protein response|activation of endoplasmic reticulum unfolded protein response|activation of erUPR|up regulation of erUPR|activation of SREBP-mediated signalling pathway|upregulation of erUPR|up regulation of ER unfolded protein response ppm 2012-02-15T11:15:35Z biological_process owl:Class
GO:1905685 biolink:NamedThing negative regulation of plasma membrane repair Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane repair. got7fsn_ti inhibition of plasma membrane repair|down-regulation of plasma membrane repair|down regulation of plasma membrane repair|downregulation of plasma membrane repair bhm 2016-11-14T10:30:38Z biological_process owl:Class
GO:0001217 biolink:NamedThing DNA-binding transcription repressor activity A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. got7fsn_ti bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding|metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription|bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding|bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding|bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding|bacterial-type DNA binding transcription repressor activity|sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription|bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding|copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription|transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding|cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription https://github.com/geneontology/go-ontology/issues/16736|https://github.com/geneontology/go-ontology/issues/20253 For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity. krc 2011-01-26T03:15:45Z GO:0001141|GO:0001218|GO:0001220|GO:0001219 molecular_function owl:Class
GO:0060350 biolink:NamedThing endochondral bone morphogenesis The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone. got7fsn_ti biological_process owl:Class
GO:0042958 biolink:NamedThing maltodextrin transmembrane transporter activity Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042956 biolink:NamedThing maltodextrin transport The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:2000314 biolink:NamedThing negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. got7fsn_ti negative regulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation vk 2011-01-18T10:26:56Z biological_process owl:Class
GO:0015742 biolink:NamedThing alpha-ketoglutarate transport The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti mitochondrial alpha-ketoglutarate/malate transport|2-oxoglutarate transport biological_process owl:Class
GO:0001580 biolink:NamedThing detection of chemical stimulus involved in sensory perception of bitter taste The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. got7fsn_ti sensory transduction of bitter taste|perception of bitter taste, detection of chemical stimulus|sensory detection of chemical stimulus during perception of bitter taste|sensory detection of bitter taste|sensory transduction of chemical stimulus during perception of bitter taste|bitter taste detection|perception of bitter taste, sensory transduction of chemical stimulus biological_process owl:Class
GO:1905269 biolink:NamedThing positive regulation of chromatin organization Any process that activates or increases the frequency, rate or extent of chromatin organization. got7fsn_ti positive regulation of establishment or maintenance of chromatin architecture|up regulation of chromatin organisation|upregulation of establishment or maintenance of chromatin architecture|positive regulation of chromatin organisation|upregulation of chromatin organization|up-regulation of chromatin organisation|activation of establishment or maintenance of chromatin architecture|up-regulation of establishment or maintenance of chromatin architecture|activation of chromatin organization|up regulation of chromatin organization|upregulation of chromatin organisation|positive regulation of chromatin modification|up regulation of establishment or maintenance of chromatin architecture|up-regulation of chromatin organization|activation of chromatin organisation pr 2016-06-15T20:14:56Z GO:1903310 biological_process owl:Class
GO:1900243 biolink:NamedThing negative regulation of synaptic vesicle endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle endocytosis. got7fsn_ti down regulation of synaptic vesicle retrieval|inhibition of synaptic vesicle endocytosis|inhibition of synaptic vesicle retrieval|down-regulation of synaptic vesicle endocytosis|down-regulation of synaptic vesicle retrieval|down regulation of synaptic vesicle endocytosis|downregulation of synaptic vesicle endocytosis|downregulation of synaptic vesicle retrieval|negative regulation of synaptic vesicle retrieval rl 2012-03-28T01:40:36Z biological_process owl:Class
GO:1904654 biolink:NamedThing negative regulation of lung alveolus development Any process that stops, prevents or reduces the frequency, rate or extent of lung alveolus development. got7fsn_ti down-regulation of alveologenesis|negative regulation of alveologenesis|inhibition of alveologenesis|down-regulation of lung alveolus development|inhibition of lung alveolus development|downregulation of alveolarization|downregulation of lung alveolus development|down-regulation of alveolarization|down regulation of alveologenesis|downregulation of alveologenesis|down regulation of lung alveolus development|negative regulation of alveolarization|inhibition of alveolarization|down regulation of alveolarization sl 2015-09-03T22:44:50Z biological_process owl:Class
GO:1905199 biolink:NamedThing manchette disassembly The disaggregation of a manchette into its constituent components. got7fsn_ti krc 2016-05-12T15:19:16Z biological_process owl:Class
GO:1900746 biolink:NamedThing regulation of vascular endothelial growth factor signaling pathway Any process that modulates the frequency, rate or extent of vascular endothelial growth factor signaling pathway. got7fsn_ti regulation of vascular endothelial growth factor signalling pathway|regulation of VEGF-activated signaling pathway|regulation of VEGF signaling pm 2012-05-29T08:28:06Z biological_process owl:Class
GO:0015139 biolink:NamedThing alpha-ketoglutarate transmembrane transporter activity Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. got7fsn_ti 2-oxoglutarate transporter activity Reactome:R-HSA-372480 molecular_function owl:Class
GO:0015136 biolink:NamedThing sialic acid transmembrane transporter activity Enables the transfer of sialic acid from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0015739 biolink:NamedThing sialic acid transport The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0030095 biolink:NamedThing chloroplast photosystem II An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone. got7fsn_ti cellular_component owl:Class
GO:0042934 biolink:NamedThing achromobactin transmembrane transporter activity Enables the transfer of achromobactin, a citrate siderophore, from one side of a membrane to the other. got7fsn_ti achromobactin transporter activity molecular_function owl:Class
GO:0033578 biolink:NamedThing protein glycosylation in Golgi The addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus. got7fsn_ti protein amino acid glycosylation in Golgi|terminal glycosylation biological_process owl:Class
GO:0015636 biolink:NamedThing short-chain fatty acid transmembrane transporter activity Enables the transfer of short-chain fatty acids from one side of a membrane to the other. Short-chain fatty acids are fatty acids with a chain length of less than C6. got7fsn_ti short-chain fatty acid transporter activity|short-chain fatty acid uptake transporter activity GO:0015635 molecular_function owl:Class
GO:0015912 biolink:NamedThing short-chain fatty acid transport The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6. got7fsn_ti biological_process owl:Class
GO:0061713 biolink:NamedThing anterior neural tube closure The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline. got7fsn_ti dph 2015-06-23T10:13:41Z biological_process owl:Class
GO:0098896 biolink:NamedThing postsynaptic early endosome membrane The lipid bilayer surrounding a postsynaptic early endosome. got7fsn_ti cellular_component owl:Class
GO:0043086 biolink:NamedThing negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. got7fsn_ti down regulation of metalloenzyme activity|down regulation of enzyme activity|inhibition of metalloenzyme activity|down-regulation of metalloenzyme activity|downregulation of enzyme activity|downregulation of metalloenzyme activity|inhibition of enzyme activity|negative regulation of enzyme activity|negative regulation of metalloenzyme activity|down-regulation of enzyme activity GO:0048553 biological_process owl:Class
GO:0015894 biolink:NamedThing acriflavine transport The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication. got7fsn_ti acriflavin transport biological_process owl:Class
GO:0002796 biolink:NamedThing positive regulation of antimicrobial peptide secretion Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion. got7fsn_ti up regulation of antimicrobial peptide secretion|activation of antimicrobial peptide secretion|stimulation of antimicrobial peptide secretion|upregulation of antimicrobial peptide secretion|up-regulation of antimicrobial peptide secretion biological_process owl:Class
GO:0017147 biolink:NamedThing Wnt-protein binding Binding to a Wnt-protein, a secreted growth factor involved in signaling. got7fsn_ti molecular_function owl:Class
GO:0042672 biolink:NamedThing retinal cone cell fate specification The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti biological_process owl:Class
GO:0060789 biolink:NamedThing hair follicle placode formation The developmental process in which a hair placode forms. An hair follicle placode is a thickening of the ectoderm that will give rise to the hair follicle bud. got7fsn_ti dph 2009-08-04T12:18:26Z biological_process owl:Class
GO:0110112 biolink:NamedThing regulation of lipid transporter activity Any process that modulates the frequency, rate, or extent of lipid transporter activity. got7fsn_ti kmv 2018-07-06T18:53:55Z biological_process owl:Class
SO:0000234 biolink:NamedThing got7fsn_ti owl:Class
GO:0015132 biolink:NamedThing prostaglandin transmembrane transporter activity Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. got7fsn_ti prostaglandin/thromboxane transporter activity Reactome:R-HSA-879528|Reactome:R-HSA-5661188 molecular_function owl:Class
GO:0060882 biolink:NamedThing basement membrane disassembly involved in semicircular canal fusion A process that results in the breakdown of the basement membrane that contributes to the process of semicircular canal fusion. got7fsn_ti basal lamina disassembly involved in semicircular canal fusion dph 2009-08-13T11:29:52Z biological_process owl:Class
GO:0009802 biolink:NamedThing cinnamic acid ester biosynthetic process The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid. got7fsn_ti cinnamic acid ester synthesis|phenylacrylic acid ester biosynthetic process|phenylacrylic acid ester biosynthesis|cinnamylic acid ester biosynthetic process|cinnamic acid ester formation|cinnamic acid ester biosynthesis|cinnamic acid ester anabolism|cinnamylic acid ester biosynthesis biological_process owl:Class
GO:0009803 biolink:NamedThing cinnamic acid metabolic process The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid. got7fsn_ti phenylacrylic acid metabolic process|phenylpropenoic acid metabolic process|phenylpropenoic acid metabolism|cinnamylic acid metabolic process|cinnamylic acid metabolism|phenylacrylic acid metabolism|cinnamic acid metabolism biological_process owl:Class
GO:0050852 biolink:NamedThing T cell receptor signaling pathway A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. got7fsn_ti T-lymphocyte receptor signalling pathway|T lymphocyte receptor signaling pathway|TCR signaling pathway|T-cell receptor signaling pathway|T-lymphocyte receptor signaling pathway|T-cell receptor signalling pathway|T lymphocyte receptor signalling pathway biological_process owl:Class
GO:0039718 biolink:NamedThing double membrane vesicle viral factory A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae. got7fsn_ti DMV viral factory bf 2013-12-19T15:31:22Z cellular_component owl:Class
GO:0010075 biolink:NamedThing regulation of meristem growth Any process involved in maintaining the size and shape of a meristem. got7fsn_ti regulation of meristem size biological_process owl:Class
NCBITaxon:71193 biolink:NamedThing got7fsn_ti owl:Class
GO:0009320 biolink:NamedThing phosphoribosylaminoimidazole carboxylase complex A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity. got7fsn_ti See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'. cellular_component owl:Class
GO:0007371 biolink:NamedThing ventral midline determination The regionalization process in which the area where the ventral midline will form is specified. got7fsn_ti determination of posterior border of ventral midline|determination of anterior border of ventral midline GO:0007373|GO:0007372 biological_process owl:Class
GO:0003038 biolink:NamedThing detection of reduced oxygen by aortic body chemoreceptor signaling The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body. got7fsn_ti detection of reduced oxygen by aortic body chemoreceptor signalling biological_process owl:Class
GO:0042327 biolink:NamedThing positive regulation of phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. got7fsn_ti up-regulation of phosphorylation|activation of phosphorylation|stimulation of phosphorylation|up regulation of phosphorylation|upregulation of phosphorylation biological_process owl:Class
GO:1904719 biolink:NamedThing positive regulation of AMPA glutamate receptor clustering Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering. got7fsn_ti activation of AMPA receptor clustering|up-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|positive regulation of AMPA receptor clustering|up regulation of AMPA receptor clustering|positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|upregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|up-regulation of AMPA glutamate receptor clustering|activation of AMPA glutamate receptor clustering|activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|up regulation of AMPA glutamate receptor clustering|up-regulation of AMPA receptor clustering|upregulation of AMPA glutamate receptor clustering|up regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|upregulation of AMPA receptor clustering hjd 2015-10-07T19:32:34Z biological_process owl:Class
GO:1905775 biolink:NamedThing negative regulation of DNA helicase activity Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity. got7fsn_ti inhibition of DNA helicase activity|downregulation of DNA helicase activity|down-regulation of ATP-dependent DNA helicase activity|downregulation of ATP-dependent DNA helicase activity|down regulation of ATP-dependent DNA helicase activity|negative regulation of ATP-dependent DNA helicase activity|inhibition of ATP-dependent DNA helicase activity|down regulation of DNA helicase activity|down-regulation of DNA helicase activity rb 2013-10-15T21:20:01Z GO:1902450 biological_process owl:Class
GO:0034897 biolink:NamedThing 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monooxygenase activity Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol. got7fsn_ti UM-BBD_reactionID:r1358 molecular_function owl:Class
GO:0035519 biolink:NamedThing protein K29-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation. got7fsn_ti protein K29-linked polyubiquitination bf 2010-05-04T04:25:48Z biological_process owl:Class
GO:0060207 biolink:NamedThing diestrus The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0050380 biolink:NamedThing undecaprenyl-diphosphatase activity Catalysis of the reaction: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H+ + phosphate. got7fsn_ti C55-isoprenyl diphosphatase activity|C(55)-isoprenyl diphosphatase activity|C55-isoprenyl pyrophosphatase activity|undecaprenyl-diphosphate phosphohydrolase activity|C(55)-isoprenyl pyrophosphatase activity|isoprenyl pyrophosphatase activity https://github.com/geneontology/go-ontology/issues/21789 RHEA:28094|EC:3.6.1.27|MetaCyc:UNDECAPRENYL-DIPHOSPHATASE-RXN|KEGG_REACTION:R05627 molecular_function owl:Class
GO:0032275 biolink:NamedThing luteinizing hormone secretion The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary. got7fsn_ti biological_process owl:Class
GO:0070987 biolink:NamedThing error-free translesion synthesis The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level. got7fsn_ti Note that 'error-free' does not mean that literally zero errors occur during DNA synthesis, but that the error rate is low, comparable to that of DNA synthesis during replication. mah 2009-10-29T02:45:42Z biological_process owl:Class
GO:0034818 biolink:NamedThing ADD 9alpha-hydroxylase activity Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin. got7fsn_ti UM-BBD_reactionID:r1149|EC:1.14.15.- molecular_function owl:Class
GO:0015887 biolink:NamedThing pantothenate transmembrane transport The process in which pantothenate is transported across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. got7fsn_ti pantothenate transport|vitamin B5 transport|pantothenate membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. biological_process owl:Class
GO:0140382 biolink:NamedThing tryptamine 4-monooxygenase activity Catalysis of the reaction: tryptamine + reduced acceptor + O(2) <=> 4-hydroxytryptamine + acceptor + H(2)O. got7fsn_ti pg 2019-11-20T10:26:21Z EC:1.14.99.59|RHEA:15865 molecular_function owl:Class
GO:0004642 biolink:NamedThing phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate. got7fsn_ti formylglycinamide ribonucloetide amidotransferase activity|phosphoribosylformylglycineamidine synthetase activity|N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)|2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)|FGAM synthase activity|phosphoribosylformylglycinamidine synthetase activity|formylglycinamide ribotide amidotransferase activity|FGAM synthetase activity|5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)|FGAR amidotransferase activity|FGARAT activity MetaCyc:FGAMSYN-RXN|RHEA:17129|EC:6.3.5.3|Reactome:R-HSA-73812|KEGG_REACTION:R04463 molecular_function owl:Class
GO:0050335 biolink:NamedThing thiocyanate isomerase activity Catalysis of the reaction: benzyl isothiocyanate = benzyl thiocyanate. got7fsn_ti isothiocyanate isomerase activity|benzyl-thiocyanate isomerase activity EC:5.99.1.1|RHEA:10004|KEGG_REACTION:R04010|MetaCyc:THIOCYANATE-ISOMERASE-RXN molecular_function owl:Class
GO:0106339 biolink:NamedThing tRNA (cytidine 32-2'-O)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + cytosine32 in tRNA= S-adenosyl-L-homocysteine + 2'-O-methylcytidine32 in tRNA. got7fsn_ti hjd 2020-11-05T22:48:53Z molecular_function owl:Class
GO:0043258 biolink:NamedThing laminin-9 complex A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains. got7fsn_ti laminin-421 complex cellular_component owl:Class
GO:0060397 biolink:NamedThing growth hormone receptor signaling pathway via JAK-STAT The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes. got7fsn_ti JAK-STAT cascade involved in growth hormone signalling pathway biological_process owl:Class
GO:0102730 biolink:NamedThing cathasterone hydroxylase activity Catalysis of the reaction: cathasterone + O2 + a reduced electron acceptor <=> teasterone + H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-716 molecular_function owl:Class
GO:0017174 biolink:NamedThing glycine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine. got7fsn_ti S-adenosyl-L-methionine:glycine N-methyltransferase activity|glycine methyltransferase activity|S-adenosyl-L-methionine:glycine methyltransferase activity|GNMT MetaCyc:2.1.1.162-RXN|EC:2.1.1.156|MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN|EC:2.1.1.162|RHEA:19937|Reactome:R-HSA-6798317|EC:2.1.1.20|KEGG_REACTION:R00367 molecular_function owl:Class
GO:0030846 biolink:NamedThing termination of RNA polymerase II transcription, poly(A)-coupled The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination. got7fsn_ti transcription termination from Pol II promoter, poly(A) coupled|transcription termination from Pol II promoter, RNA polymerase(A) coupled|termination of RNA polymerase II transcription, polyadenylation-coupled biological_process owl:Class
GO:0098017 biolink:NamedThing viral capsid, major subunit The part of the viral capsid that comprises the most common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the hexameric capsomeres are major subunits. got7fsn_ti major head protein|major capsomere bm 2012-07-19T11:21:21Z cellular_component owl:Class
GO:0004060 biolink:NamedThing arylamine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. got7fsn_ti p-aminosalicylate N-acetyltransferase activity|acetyl CoA-arylamine N-acetyltransferase activity|beta-naphthylamine N-acetyltransferase activity|4-aminobiphenyl N-acetyltransferase activity|arylamine acetyltransferase activity|acetyl-CoA:arylamine N-acetyltransferase activity|2-naphthylamine N-acetyltransferase activity|arylamine acetylase activity|indoleamine N-acetyltransferase activity EC:2.3.1.5|UM-BBD_enzymeID:e0341|Reactome:R-HSA-174963|RHEA:16613|Reactome:R-HSA-174967|MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:0047977 biolink:NamedThing hepoxilin-epoxide hydrolase activity Catalysis of the reaction: (5Z,9E,14Z)-(8x,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate + H2O = (5Z,9E,14Z)-(8x,11x,12S)-8,11,12-trihydroxyicosa-5,9,14-trienoate. got7fsn_ti (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate hydrolase activity|hepoxilin A(3) hydrolase activity|hepoxylin hydrolase activity|hepoxilin epoxide hydrolase activity|hepoxilin A3 hydrolase activity Reactome:R-HSA-2161949|MetaCyc:HEPOXILIN-EPOXIDE-HYDROLASE-RXN|EC:3.3.2.7|RHEA:16665 molecular_function owl:Class
GO:0009342 biolink:NamedThing glutamate synthase complex (NADPH) A complex that possesses glutamate synthase (NADPH) activity. got7fsn_ti cellular_component owl:Class
GO:0102595 biolink:NamedThing cyanidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent) activity Catalysis of the reaction: cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) + 1-O-4-hydroxybenzoyl-beta-D-glucose <=> cyanidin 3-O-glucoside-7-O-(6-O-(4-O-(6-O-(p-hydroxybenzoyl)-glucosyl)-oxybenzoyl)-glucoside) + beta-D-glucose. got7fsn_ti MetaCyc:RXN-15374 molecular_function owl:Class
GO:0003882 biolink:NamedThing CDP-diacylglycerol-serine O-phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine. got7fsn_ti CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity|CDP-diglyceride:serine phosphatidyltransferase activity|CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity|CDPdiglyceride-serine O-phosphatidyltransferase activity|phosphatidylserine synthase activity|cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity|PS synthase activity|cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity|CDP-diglyceride-L-serine phosphatidyltransferase activity|cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity|serine exchange enzyme|CDP-diglycerine-serine O-phosphatidyltransferase activity|CDPdiacylglycerol-serine O-phosphatidyltransferase activity|phosphatidylserine synthetase activity MetaCyc:PHOSPHASERSYN-RXN|RHEA:16913|EC:2.7.8.8 molecular_function owl:Class
GO:0034882 biolink:NamedThing cis-aconitamide amidase activity Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3. got7fsn_ti UM-BBD_reactionID:r1344 molecular_function owl:Class
GO:0047186 biolink:NamedThing N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity Catalysis of the reaction: N-acetylneuraminate + acetyl-CoA = N-acetyl-7-O(or 9-O)-acetylneuraminate + CoA. got7fsn_ti N-acetylneuraminate 7,8-O-acetyltransferase activity|N-acetylneuraminate 7(8)-O-acetyltransferase activity|acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase activity|acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase activity|acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity|sialate O-acetyltransferase|N-acetylneuraminate O7-(or O9-)acetyltransferase activity|acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase activity|acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase activity|glycoprotein 7(9)-O-acetyltransferase activity MetaCyc:2.3.1.45-RXN|RHEA:20808|EC:2.3.1.45 molecular_function owl:Class
GO:0016521 biolink:NamedThing pituitary adenylate cyclase activating polypeptide activity The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation. got7fsn_ti pituitary adenylyl cyclase activating polypeptide activity molecular_function owl:Class
GO:0035624 biolink:NamedThing receptor transactivation The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer. got7fsn_ti bf 2010-12-08T04:18:18Z biological_process owl:Class
GO:0140344 biolink:NamedThing triglyceride transfer activity Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location. got7fsn_ti triglyceride carrier activity pg 2019-05-16T11:53:59Z molecular_function owl:Class
GO:0018826 biolink:NamedThing methionine gamma-lyase activity Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate. got7fsn_ti L-methionine methanethiol-lyase (deaminating)|L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)|methionine lyase activity|L-methioninase activity|methionine dethiomethylase activity|L-methionine gamma-lyase activity|methioninase activity MetaCyc:METHIONINE-GAMMA-LYASE-RXN|EC:4.4.1.11|UM-BBD_reactionID:r0432|RHEA:23800 molecular_function owl:Class
GO:0050341 biolink:NamedThing thymine dioxygenase activity Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2. got7fsn_ti 5-hydroxymethyluracil oxygenase activity|thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)|5-hydroxy-methyluracil dioxygenase activity|thymine,2-oxoglutarate dioxygenase activity|thymine 7-hydroxylase activity MetaCyc:THYMINE-DIOXYGENASE-RXN|RHEA:10316|EC:1.14.11.6 molecular_function owl:Class
GO:0031896 biolink:NamedThing V2 vasopressin receptor binding Binding to a V2 vasopressin receptor. got7fsn_ti V2 vasopressin receptor ligand molecular_function owl:Class
GO:0047420 biolink:NamedThing N-acyl-D-amino-acid deacylase activity Catalysis of the reaction: H2O + N-acyl-D-amino acid = D-amino acid + an acid. got7fsn_ti D-aminoacylase activity|N-acyl-D-amino acid amidohydrolase activity MetaCyc:3.5.1.81-RXN|EC:3.5.1.81|RHEA:18309 molecular_function owl:Class
GO:0060064 biolink:NamedThing Spemann organizer formation at the anterior end of the primitive streak Formation of the specialized region at the anterior end of the primitive streak of the embryo that acts as the main signaling center establishing the body plan. got7fsn_ti Spemann-Mangold organizer formation at the anterior end of the primitive streak|Spemann organizer formation in amniotes|Spemann's organizer formation at the anterior end of the primitive streak Occurs in reptiles, birds and mammals. biological_process owl:Class
GO:0018752 biolink:NamedThing epsilon-caprolactam lactamase activity Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate. got7fsn_ti UM-BBD_reactionID:r0448|MetaCyc:R561-RXN molecular_function owl:Class
GO:0106290 biolink:NamedThing trans-cinnamate-CoA ligase activity Catalysis of the reaction: (E)-cinnamate + ATP + CoA = (E)-cinnamoyl-CoA + AMP + diphosphate. got7fsn_ti hjd 2020-08-18T16:53:10Z RHEA:64788 molecular_function owl:Class
GO:0009665 biolink:NamedThing plastid inheritance The partitioning of plastids between daughter cells at cell division. got7fsn_ti biological_process owl:Class
GO:0004999 biolink:NamedThing vasoactive intestinal polypeptide receptor activity Combining with vasoactive intestinal polypeptide to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0098528 biolink:NamedThing skeletal muscle fiber differentiation The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract. got7fsn_ti dos 2013-10-15T14:00:34Z biological_process owl:Class
GO:0090574 biolink:NamedThing RNA polymerase V transcription repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter. got7fsn_ti tb 2014-05-09T13:26:16Z cellular_component owl:Class
GO:0009764 biolink:NamedThing PEP carboxykinase C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK). got7fsn_ti biological_process owl:Class
GO:0001682 biolink:NamedThing tRNA 5'-leader removal Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. got7fsn_ti tRNA 5' leader removal biological_process owl:Class
GO:0000333 biolink:NamedThing telomerase catalytic core complex The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. got7fsn_ti TERT-TERC complex cellular_component owl:Class
GO:0102726 biolink:NamedThing DIMBOA glucoside beta-D-glucosidase activity Catalysis of the reaction: (2R)-DIMBOA glucoside + H2O = H+ + DIMBOA + beta-D-glucose. got7fsn_ti MetaCyc:RXN-7082|RHEA:33975|EC:3.2.1.182 molecular_function owl:Class
CHEBI:24431 biolink:NamedThing got7fsn_ti owl:Class
GO:0018786 biolink:NamedThing haloalkane dehalogenase activity Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide. got7fsn_ti 1-haloalkane dehalogenase activity|1-chlorohexane halidohydrolase activity|1-haloalkane halidohydrolase activity EC:3.8.1.5|MetaCyc:HALOALKANE-DEHALOGENASE-RXN|RHEA:19081|UM-BBD_enzymeID:e0003 molecular_function owl:Class
GO:0032794 biolink:NamedThing GTPase activating protein binding Binding to a GTPase activating protein. got7fsn_ti GAP binding molecular_function owl:Class
GO:0046512 biolink:NamedThing sphingosine biosynthetic process The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues. got7fsn_ti sphingosine biosynthesis|sphingosine formation|sphingosine synthesis|sphingosine anabolism biological_process owl:Class
GO:0001784 biolink:NamedThing phosphotyrosine residue binding Binding to a phosphorylated tyrosine residue within a protein. got7fsn_ti phosphotyrosine binding molecular_function owl:Class
GO:0047166 biolink:NamedThing 1-alkenylglycerophosphoethanolamine O-acyltransferase activity Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA. got7fsn_ti acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity RHEA:16245|MetaCyc:2.3.1.121-RXN|EC:2.3.1.121 molecular_function owl:Class
GO:0004734 biolink:NamedThing pyrimidodiazepine synthase activity Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione. got7fsn_ti PDA synthase activity|pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing) EC:1.5.4.1|RHEA:10720|MetaCyc:1.5.4.1-RXN molecular_function owl:Class
GO:0030596 biolink:NamedThing alpha-L-rhamnosidase activity Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides. got7fsn_ti alpha-L-rhamnosidase N|alpha-L-rhamnoside rhamnohydrolase activity|alpha-L-rhamnosidase T MetaCyc:3.2.1.40-RXN|EC:3.2.1.40 molecular_function owl:Class
GO:0047582 biolink:NamedThing 4-methyleneglutaminase activity Catalysis of the reaction: 4-methylene-L-glutamine + H(2)O = 4-methylene-L-glutamate + NH(4)(+). got7fsn_ti 4-methyleneglutamine amidohydrolase activity|4-methylene-L-glutamine amidohydrolase activity|4-methyleneglutamine deamidase activity EC:3.5.1.67|KEGG_REACTION:R02712|RHEA:14741|MetaCyc:4-METHYLENEGLUTAMINASE-RXN molecular_function owl:Class
GO:0035653 biolink:NamedThing clathrin-coated vesicle cargo loading, AP-1-mediated Formation of a macromolecular complex between proteins of the AP-1 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking. got7fsn_ti cargo loading into clathrin-coated vesicle, AP-1-mediated bf 2011-01-25T11:01:38Z biological_process owl:Class
GO:0097152 biolink:NamedThing mesenchymal cell apoptotic process Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types. got7fsn_ti mesenchymal cell apoptosis pr 2011-09-06T02:31:59Z biological_process owl:Class
GO:0097407 biolink:NamedThing Bunina body Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles. got7fsn_ti pr 2012-10-31T13:52:30Z NIF_Subcellular:nlx_subcell_20090101 cellular_component owl:Class
GO:0103054 biolink:NamedThing gibberellin A12, 2-oxoglutarate:oxygen oxidoreductase activity (gibberellin A15-forming) Catalysis of the reaction: gibberellin A12 + O2 + 2-oxoglutarate <=> gibberellin A15 + carbon dioxide + succinate. got7fsn_ti RHEA:60776|MetaCyc:RXN1F-162 molecular_function owl:Class
GO:0047522 biolink:NamedThing 15-oxoprostaglandin 13-oxidase activity Catalysis of the reaction: (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprostanoate + NAD(P)+ -> (5Z)-(15S)-11-alpha-hydroxy-9,15-dioxoprosta-13-enoate + NAD(P)H + H+. got7fsn_ti (5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity Note that this is the reverse of the reaction described in '13-prostaglandin reductase activity ; GO:0036132'. MetaCyc:15-OXOPROSTAGLANDIN-13-REDUCTASE-RXN|KEGG_REACTION:R04557|EC:1.3.1.48|KEGG_REACTION:R04556 molecular_function owl:Class
GO:0061776 biolink:NamedThing topological DNA co-entrapment activity A DNA binding activity in which a protein complex interacts with more than one DNA duplex to encircle the DNA molecules with a loose fitting ring. got7fsn_ti topological DNA entrapment activity https://github.com/geneontology/go-ontology/issues/20522 dph 2016-07-13T13:10:15Z molecular_function owl:Class
GO:0031802 biolink:NamedThing type 5 metabotropic glutamate receptor binding Binding to a type 5 metabotropic glutamate receptor. got7fsn_ti type 5 metabotropic glutamate receptor ligand molecular_function owl:Class
GO:0018812 biolink:NamedThing 3-hydroxyacyl-CoA dehydratase activity Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA). got7fsn_ti Reactome:R-HSA-8957389 molecular_function owl:Class
GO:0009255 biolink:NamedThing Entner-Doudoroff pathway through 6-phosphogluconate A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. got7fsn_ti MetaCyc:ENTNER-DOUDOROFF-PWY-I biological_process owl:Class
GO:0030883 biolink:NamedThing endogenous lipid antigen binding Binding to an endogenous cellular lipid antigen. got7fsn_ti molecular_function owl:Class
GO:0102188 biolink:NamedThing 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-methyl-5alpha-cholesta-7,24-dien-3beta-ol + O2 + NADH(2-) + H+ <=> 4alpha-hydroxymethyl-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) + H2O. got7fsn_ti MetaCyc:RXN-11956 molecular_function owl:Class
GO:0032998 biolink:NamedThing Fc-epsilon receptor I complex A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE. got7fsn_ti FceRI complex|immunoglobulin E receptor complex|IgE receptor complex cellular_component owl:Class
GO:0050278 biolink:NamedThing sedoheptulose-bisphosphatase activity Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate. got7fsn_ti sedoheptulose-1,7-bisphosphate 1-phosphohydrolase activity|sedoheptulose 1,7-bisphosphatase activity|sedoheptulose diphosphatase activity|sedoheptulose bisphosphatase activity|sedoheptulose 1,7-diphosphate phosphatase activity|SBPase activity|sedoheptulose-1,7-bisphosphatase activity|sedoheptulose 1,7-diphosphatase activity EC:3.1.3.37|MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN|RHEA:17461 molecular_function owl:Class
GO:0098615 biolink:NamedThing dimethyl selenide methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium. got7fsn_ti Reactome:R-HSA-2408554 molecular_function owl:Class
GO:0010424 biolink:NamedThing DNA methylation on cytosine within a CG sequence The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule. got7fsn_ti cytosine methylation within a CG sequence biological_process owl:Class
GO:0102742 biolink:NamedThing R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity Catalysis of the reaction: H+ + 3,4-dihydroxyphenylpyruvate + NADPH <=> (2R)-3-(3,4-dihydroxyphenyl)lactate + NADP. got7fsn_ti EC:1.1.1.237|MetaCyc:RXN-7632 molecular_function owl:Class
GO:0003910 biolink:NamedThing DNA ligase (ATP) activity Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). got7fsn_ti poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)|deoxyribonucleic ligase|DNA repair enzyme activity|deoxyribonucleic repair enzyme|deoxyribonucleic acid joinase|deoxyribonucleic acid ligase|deoxyribonucleic joinase|polynucleotide ligase (ATP) activity|polynucleotide ligase|deoxyribonucleic acid repair enzyme|DNA-joining enzyme|DNA joinase activity|deoxyribonucleic-joining enzyme|polydeoxyribonucleotide synthase (ATP) activity|deoxyribonucleic acid-joining enzyme|deoxyribonucleate ligase|sealase activity EC:6.5.1.1|MetaCyc:DNA-LIGASE-ATP-RXN molecular_function owl:Class
GO:0102249 biolink:NamedThing phosphatidylcholine:diacylglycerol cholinephosphotransferase activity Catalysis of the reaction: a phosphatidylcholine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycerol + a phosphatidylcholine. got7fsn_ti MetaCyc:RXN-12386 molecular_function owl:Class
GO:0090548 biolink:NamedThing response to nitrate starvation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nitrate. got7fsn_ti tb 2013-04-22T13:57:16Z biological_process owl:Class
GO:0050126 biolink:NamedThing N-carbamoylputrescine amidase activity Catalysis of the reaction: N-carbamoylputrescine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + putrescine. got7fsn_ti NCP|N-carbamoylputrescine amidohydrolase activity|carbamoylputrescine hydrolase activity KEGG_REACTION:R01152|RHEA:22284|EC:3.5.1.53|MetaCyc:N-CARBAMOYLPUTRESCINE-AMIDASE-RXN molecular_function owl:Class
GO:0102461 biolink:NamedThing kaempferol 3-sophoroside 7-O-rhamnosyltransferase activity Catalysis of the reaction: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> kaempferol 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP. got7fsn_ti MetaCyc:RXN-14009 molecular_function owl:Class
GO:1990651 biolink:NamedThing inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate. got7fsn_ti al 2015-02-23T11:17:19Z molecular_function owl:Class
GO:0035164 biolink:NamedThing embryonic plasmatocyte differentiation The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte. got7fsn_ti embryonic plasmatocyte cell differentiation biological_process owl:Class
GO:0106316 biolink:NamedThing nitrite reductase NADH activity Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+. got7fsn_ti hjd 2020-09-23T14:34:02Z RHEA:24628 molecular_function owl:Class
GO:0070528 biolink:NamedThing protein kinase C signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. got7fsn_ti protein kinase C signaling cascade|PKC signaling cascade|protein kinase C signalling cascade|PKC signal transduction|protein kinase C signal transduction biological_process owl:Class
GO:0050199 biolink:NamedThing piperidine N-piperoyltransferase activity Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H(+). got7fsn_ti (E,E)-piperoyl-CoA:piperidine N-piperoyltransferase activity|piperoyl-CoA:piperidine N-piperoyltransferase activity|piperidine piperoyltransferase activity EC:2.3.1.145|KEGG_REACTION:R03994|MetaCyc:PIPERIDINE-N-PIPEROYLTRANSFERASE-RXN|RHEA:14561 molecular_function owl:Class
GO:0035971 biolink:NamedThing peptidyl-histidine dephosphorylation The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine. got7fsn_ti bf 2011-08-08T03:26:02Z biological_process owl:Class
GO:0038195 biolink:NamedThing urokinase plasminogen activator signaling pathway A series of molecular signals initiated by the binding of urokinase plasminogen activator to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti uPA signaling pathway bf 2013-10-28T09:14:13Z biological_process owl:Class
GO:0005147 biolink:NamedThing oncostatin-M receptor binding Binding to an oncostatin-M receptor. got7fsn_ti oncostatin-M|oncostatin-M receptor ligand molecular_function owl:Class
GO:0050142 biolink:NamedThing nitrogenase (flavodoxin) activity Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate. got7fsn_ti reduced flavodoxin:dinitrogen oxidoreductase (ATP-hydrolysing) MetaCyc:NITROGENASE-FLAVODOXIN-RXN|RHEA:15645|EC:1.19.6.1 molecular_function owl:Class
GO:0031417 biolink:NamedThing NatC complex A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p. got7fsn_ti N-terminal acetyltransferase C complex cellular_component owl:Class
GO:0097463 biolink:NamedThing gemmule Spine-like process found on some neurons, e.g., periglomerular cells of olfactory cortex. got7fsn_ti pr 2012-12-21T07:59:04Z NIF_Subcellular:nlx_subcell_1005003 cellular_component owl:Class
GO:0071179 biolink:NamedThing MAML3-RBP-Jkappa-ICN1 complex A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML3-RBP-Jkappa-Notch1 complex mah 2009-11-23T02:50:39Z cellular_component owl:Class
GO:0102027 biolink:NamedThing S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity Catalysis of the reaction: 2-demethylmenaquinol-8 + S-adenosyl-L-methionine <=> menaquinol-8 + H+ + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.163|MetaCyc:ADOMET-DMK-METHYLTRANSFER-RXN|RHEA:30063 molecular_function owl:Class
GO:0060798 biolink:NamedThing transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the specification of a mesodermal fate. got7fsn_ti transforming growth factor beta receptor signalling pathway involved in mesodermal cell fate specification dph 2009-08-06T11:16:11Z biological_process owl:Class
GO:0102365 biolink:NamedThing taxusin 2-alpha-hydroxylase activity Catalysis of the reaction: taxusin + NADPH + O2 + H+ = 2-alpha-hydroxytaxusin + NADP + H2O. got7fsn_ti MetaCyc:RXN-13486 molecular_function owl:Class
GO:0072435 biolink:NamedThing response to mitotic G2 DNA damage checkpoint signaling A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling. got7fsn_ti mitotic G2/M transition decatenation checkpoint effector process|response to mitotic G2/M transition DNA damage checkpoint signaling|response to signal involved in mitotic G2/M transition DNA damage checkpoint|mitotic G2/M transition DNA damage checkpoint effector process|response to signal involved in mitotic G2/M transition decatenation checkpoint|response to mitotic G2/M transition decatenation checkpoint signaling mah 2010-12-08T04:44:01Z GO:0072458 biological_process owl:Class
GO:0071311 biolink:NamedThing cellular response to acetate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus. got7fsn_ti mah 2009-12-10T04:48:16Z biological_process owl:Class
GO:0106234 biolink:NamedThing outer membrane protein complex Any protein complex that is part of the bacterial outer membrane. An example In E.coli, is RcsF associated with any one of several outer membrane beta-barrel proteins (OMPs), such as OmpA, OmpF, or OmpcC. got7fsn_ti hjd 2019-11-07T19:20:43Z cellular_component owl:Class
GO:0018403 biolink:NamedThing protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. got7fsn_ti protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine RESID:AA0209 biological_process owl:Class
GO:0051009 biolink:NamedThing O-acetylhomoserine sulfhydrylase activity Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate. got7fsn_ti RHEA:27822|MetaCyc:ACETYLHOMOSER-CYS-RXN molecular_function owl:Class
GO:0051935 biolink:NamedThing glutamate reuptake The uptake of L-glutamate by neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. got7fsn_ti glutamate recycling|L-glutamate uptake involved in synaptic transmission|glutamate import into neuron|glutamate import into glial cell|glutamate uptake during transmission of nerve impulse|L-glutamate reuptake|L-glutamate uptake during transmission of nerve impulse biological_process owl:Class
GO:0098712 biolink:NamedThing L-glutamate import across plasma membrane The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti L-glutamate import into cell|L-glutamate(1-) import into cell|L-glutamate(1-) import across plasma membrane mah 2013-06-12T12:32:47Z GO:1990123|GO:1903802 biological_process owl:Class
GO:0102953 biolink:NamedThing hypoglycin A gamma-glutamyl transpeptidase activity Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B. got7fsn_ti MetaCyc:RXN-9157|EC:2.3.2.2 molecular_function owl:Class
GO:0034717 biolink:NamedThing Gemin6-Gemin7-unrip complex A protein complex that contains Gemin6, Gemin7, and unrip (STRAP), and can bind to snRNAs; may play a role in snRNP assembly. got7fsn_ti cellular_component owl:Class
GO:0004350 biolink:NamedThing glutamate-5-semialdehyde dehydrogenase activity Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH. got7fsn_ti glutamate-phosphate reductase activity|gamma-glutamylphosphate reductase activity|L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)|gamma-glutamyl phosphate reductase activity|glutamate semialdehyde dehydrogenase activity|glutamylphosphate reductase activity|glutamate-gamma-semialdehyde dehydrogenase activity|glutamyl-gamma-semialdehyde dehydrogenase activity|beta-glutamylphosphate reductase activity GO:0001513 KEGG_REACTION:R03313|RHEA:19541|MetaCyc:GLUTSEMIALDEHYDROG-RXN|EC:1.2.1.41 molecular_function owl:Class
GO:0001785 biolink:NamedThing prostaglandin J receptor activity Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity. got7fsn_ti PGJ receptor activity|PGJ(2) receptor activity molecular_function owl:Class
GO:1900818 biolink:NamedThing ochratoxin A biosynthetic process The chemical reactions and pathways resulting in the formation of ochratoxin A. got7fsn_ti Ochratoxin A synthesis|Ochratoxin A biosynthetic process|Ochratoxin A anabolism|Ochratoxin A formation|Ochratoxin A biosynthesis di 2012-06-04T10:13:32Z biological_process owl:Class
GO:0008706 biolink:NamedThing 6-phospho-beta-glucosidase activity Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose. got7fsn_ti phospho-beta-glucosidase activity|phospho-beta-glucosidase A|phosphocellobiase activity|6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity RHEA:10772|EC:3.2.1.86|MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN molecular_function owl:Class
GO:0097676 biolink:NamedThing histone H3-K36 dimethylation The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone. got7fsn_ti pr 2014-11-04T10:38:05Z biological_process owl:Class
GO:0052797 biolink:NamedThing 4-O-methyl-glucuronoyl methylesterase activity Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X]. got7fsn_ti glucuronoyl esterase activity molecular_function owl:Class
GO:0035538 biolink:NamedThing carbohydrate response element binding Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes. got7fsn_ti ChoRE binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. bf 2010-05-07T10:48:30Z molecular_function owl:Class
GO:0042835 biolink:NamedThing BRE binding Binding to a BRE RNA element (Bruno response element). got7fsn_ti molecular_function owl:Class
GO:0004096 biolink:NamedThing catalase activity Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O. got7fsn_ti CAT|heme catalase activity|caperase activity|haem catalase activity|manganese catalase activity|catalase-peroxidase activity|optidase activity|hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|bacterial catalase-peroxidase activity|catalase reaction|equilase activity GO:0016952|GO:0016953 UM-BBD_enzymeID:e0834|RHEA:20309|EC:1.11.1.6|Reactome:R-HSA-76031|Reactome:R-HSA-1222704|MetaCyc:CATAL-RXN molecular_function owl:Class
GO:0036219 biolink:NamedThing GTP diphosphatase activity Catalysis of the reaction: GTP + H2O = GMP + diphosphate. got7fsn_ti GTP diphosphohydrolase activity|GTP diphosphohydrolase (diphosphate-forming); guanosine 5'-triphosphate pyrophosphohydrolase bf 2012-05-08T01:47:59Z KEGG_REACTION:R00426|RHEA:29391 molecular_function owl:Class
GO:0047158 biolink:NamedThing sinapoylglucose-sinapoylglucose O-sinapoyltransferase activity Catalysis of the reaction: 2 1-O-sinapoyl-beta-D-glucose = 1,2-di-O-sinapoyl-beta-D-glucose + D-glucose. got7fsn_ti 1-(hydroxycinnamoyl)-glucose:1-(hydroxycinnamoyl)-glucose hydroxycinnamoyltransferase activity|hydroxycinnamoylglucose-hydroxycinnamoylglucose hydroxycinnamoyltransferase activity|1-O-(4-hydroxy-3,5-dimethoxycinnamoyl)-beta-D-glucoside:1-O-(4-hydroxy-3,5-dimethoxycinnamoyl-beta-D-glucoside 1-O-sinapoyltransferase activity KEGG_REACTION:R00063|MetaCyc:2.3.1.103-RXN|RHEA:22664|EC:2.3.1.103 molecular_function owl:Class
GO:0047352 biolink:NamedThing adenylylsulfate-ammonia adenylyltransferase activity Catalysis of the reaction: 5'-adenylyl sulfate + NH(4)(+) = adenosine 5'-phosphoramidate + 2 H(+) + sulfate. got7fsn_ti adenylylsulfate:ammonia adenylyltransferase activity|adenylylsulphate-ammonia adenylyltransferase activity|APSAT RHEA:19197|KEGG_REACTION:R01619|MetaCyc:2.7.7.51-RXN|EC:2.7.7.51 molecular_function owl:Class
GO:0070383 biolink:NamedThing DNA cytosine deamination The removal of an amino group from a cytosine residue in DNA, forming a uracil residue. got7fsn_ti biological_process owl:Class
GO:0070689 biolink:NamedThing L-threonine catabolic process to propionate The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound propionate. got7fsn_ti threonine catabolic process to propionate|L-threonine degradation to propionate|L-threonine breakdown to propionate|L-threonine catabolism to propionate mah 2009-06-03T01:36:54Z MetaCyc:PWY-5437 biological_process owl:Class
GO:0001093 biolink:NamedThing TFIIB-class transcription factor binding Binding to a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. got7fsn_ti krc 2010-10-28T02:46:15Z molecular_function owl:Class
GO:0052577 biolink:NamedThing germacrene-D synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (-)-germacrene D + diphosphate. got7fsn_ti 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(-)-Germacrene D-forming] activity ai 2010-08-09T01:39:02Z KEGG_REACTION:R07648|RHEA:12016|EC:4.2.3.22|MetaCyc:RXN-8562 molecular_function owl:Class
GO:0042313 biolink:NamedThing protein kinase C deactivation Any process resulting in the inhibition or termination of the activity of protein kinase C. got7fsn_ti PKC deactivation biological_process owl:Class
GO:0046185 biolink:NamedThing aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O. got7fsn_ti aldehyde degradation|aldehyde breakdown|aldehyde catabolism biological_process owl:Class
GO:0032209 biolink:NamedThing positive regulation of telomere maintenance via recombination Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length. got7fsn_ti up-regulation of telomere maintenance via recombination|upregulation of telomere maintenance via recombination|activation of telomere maintenance via recombination|up regulation of telomere maintenance via recombination|stimulation of telomere maintenance via recombination biological_process owl:Class
GO:0019962 biolink:NamedThing type I interferon binding Binding to a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families. got7fsn_ti interferon-alpha/beta binding|type I IFN binding|interferon-kappa binding|interferon-delta binding|interferon-tau binding|interferon-omega binding|interferon-alpha binding|interferon-zeta binding|interferon-beta binding|interferon-epsilon binding molecular_function owl:Class
GO:0043896 biolink:NamedThing glucan 1,6-alpha-glucosidase activity Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides. got7fsn_ti glucodextrinase|exo-1,6-alpha-glucosidase activity|glucan alpha-1,6-D-glucohydrolase activity|exo-1,6-beta-glucosidase|glucodextranase activity|glucan-1,6-alpha-glucosidase activity MetaCyc:3.2.1.70-RXN|EC:3.2.1.70 molecular_function owl:Class
GO:0047331 biolink:NamedThing diphosphate-glycerol phosphotransferase activity Catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H(+) + phosphate. got7fsn_ti pyrophosphate--glycerol phosphotransferase activity|PPi-glycerol phosphotransferase activity|diphosphate:glycerol 1-phosphotransferase activity MetaCyc:2.7.1.79-RXN|EC:2.7.1.79|KEGG_REACTION:R01044|RHEA:13689 molecular_function owl:Class
GO:0005174 biolink:NamedThing CD40 receptor binding Binding to CD40, a receptor found on the surface of all B-lymphocytes. got7fsn_ti molecular_function owl:Class
GO:0004591 biolink:NamedThing oxoglutarate dehydrogenase (succinyl-transferring) activity Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. got7fsn_ti 2-ketoglutarate dehydrogenase activity|alpha-ketoglutaric dehydrogenase activity|alpha-ketoglutarate dehydrogenase activity|alpha-oxoglutarate dehydrogenase activity|oxoglutarate dehydrogenase (lipoamide) activity|2-oxoglutarate: lipoate oxidoreductase activity|oxoglutarate dehydrogenase activity|alpha-ketoglutaric acid dehydrogenase activity|2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity|OGDC activity|2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)|oxoglutarate decarboxylase activity|ketoglutaric dehydrogenase activity|AKGDH activity|2-oxoglutarate dehydrogenase activity MetaCyc:2OXOGLUTDECARB-RXN|EC:1.2.4.2|RHEA:12188 molecular_function owl:Class
GO:0047100 biolink:NamedThing glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity Catalysis of the reaction: phosphate + NADP+ + glyceraldehyde-3-phosphate = NADPH + 3-phospho-D-glyceroyl-phosphate. got7fsn_ti glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)|D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating)|NADP-triose phosphate dehydrogenase activity|triosephosphate dehydrogenase (NADP)|triosephosphate dehydrogenase (NADP+) activity|triosephosphate dehydrogenase (NADP(+)) activity|dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)|NADP-dependent glyceraldehyde-3-phosphate dehydrogenase activity|NADP-dependent glyceraldehyde phosphate dehydrogenase activity MetaCyc:1.2.1.13-RXN|EC:1.2.1.13|RHEA:10296 molecular_function owl:Class
GO:0001918 biolink:NamedThing farnesylated protein binding Binding to a farnesylated protein. got7fsn_ti molecular_function owl:Class
GO:0033767 biolink:NamedThing 4-hydroxyacetophenone monooxygenase activity Catalysis of the reaction: 4'-hydroxyacetophenone + H(+) + NADPH + O(2) = 4-hydroxyphenyl acetate + H(2)O + NADP(+). got7fsn_ti (4-hydroxyphenyl)ethan-1-one,NADPH:oxygen oxidoreductase (ester-forming) activity|HAPMO KEGG_REACTION:R06892|RHEA:22916|EC:1.14.13.84|UM-BBD_reactionID:r0756|MetaCyc:1.14.13.84-RXN molecular_function owl:Class
GO:0102810 biolink:NamedThing glutarate-semialdehyde dehydrogenase (NADP+) activity Catalysis of the reaction: 5-oxopentanoate + NADP + H2O = glutarate + NADPH + 2 H+. got7fsn_ti RHEA:57832|MetaCyc:RXN-8182 molecular_function owl:Class
GO:0050084 biolink:NamedThing mannitol-1-phosphatase activity Catalysis of the reaction: D-mannitol 1-phosphate + H(2)O = D-mannitol + 2 H(+) + phosphate. got7fsn_ti D-mannitol-1-phosphate phosphohydrolase activity|mannitol-1-phosphate phosphatase activity KEGG_REACTION:R02167|EC:3.1.3.22|RHEA:19537|MetaCyc:MANNITOL-1-PHOSPHATASE-RXN molecular_function owl:Class
GO:1990874 biolink:NamedThing vascular associated smooth muscle cell proliferation The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels. got7fsn_ti VSMC proliferation|vascular smooth muscle cell proliferation sl 2015-09-29T16:34:59Z biological_process owl:Class
GO:0048659 biolink:NamedThing smooth muscle cell proliferation The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population. got7fsn_ti SMC proliferation biological_process owl:Class
GO:0038048 biolink:NamedThing dynorphin receptor activity Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin. got7fsn_ti kappa-opioid receptor activity bf 2011-11-14T01:48:02Z molecular_function owl:Class
GO:0009762 biolink:NamedThing NADP-malic enzyme C4 photosynthesis The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme. got7fsn_ti MetaCyc:PWY-241 biological_process owl:Class
GO:0031994 biolink:NamedThing insulin-like growth factor I binding Binding to insulin-like growth factor I. got7fsn_ti IGF-I binding molecular_function owl:Class
GO:0047120 biolink:NamedThing (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase activity Catalysis of the reaction: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+) = 3,4-dihydroxybenzoate + CO(2) + NADH. got7fsn_ti cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate:NAD+ oxidoreductase (decarboxylating)|(3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate:NAD+ oxidoreductase activity|terephthalate 1,2-cis-dihydrodiol dehydrogenase activity|dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity|(1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase activity GO:0018514 UM-BBD_reactionID:r0151|RHEA:10744|MetaCyc:1.3.1.53-RXN|EC:1.3.1.53|KEGG_REACTION:R01633 molecular_function owl:Class
GO:0008921 biolink:NamedThing lipopolysaccharide-1,6-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide. got7fsn_ti LPS-1,6-galactosyltransferase activity molecular_function owl:Class
GO:0090591 biolink:NamedThing protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in). got7fsn_ti tb 2014-06-04T16:33:01Z molecular_function owl:Class
GO:0102903 biolink:NamedThing gamma-terpinene synthase activity Catalysis of the reaction: geranyl diphosphate = gamma-terpinene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8547|RHEA:32559|EC:4.2.3.114 molecular_function owl:Class
GO:0140373 biolink:NamedThing histone H3-K14 ubiquitination The modification of histone H3 by the addition of one or more ubiquitin groups to a lysine residue at position 14 of the histone. got7fsn_ti histone H3K14 ubiquitination|histone H3 ubiquitination at K14|histone H3-K14 ubiquitylation pg 2019-10-03T15:31:15Z biological_process owl:Class
GO:0030962 biolink:NamedThing peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine. got7fsn_ti RESID:AA0369 biological_process owl:Class
GO:0033992 biolink:NamedThing 1,5-anhydro-D-fructose dehydratase activity Catalysis of the reaction: 1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O. got7fsn_ti 1,5-anhydro-D-fructose 4-dehydratase activity|1,5-anhydro-D-fructose hydro-lyase activity|1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming) activity|1,5-anhydro-D-fructose hydrolyase activity|AF dehydratase activity|1,5-anhydro-D-arabino-hex-2-ulose dehydratase activity|AFDH MetaCyc:4.2.1.111-RXN|EC:4.2.1.111|RHEA:15725 molecular_function owl:Class
GO:0052875 biolink:NamedThing riboflavin reductase (NADH) activity Catalysis of the reaction: reduced riboflavin + NAD+ = riboflavin + NADH + 2 H+. got7fsn_ti riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide) reductase activity|NAD(P)H:riboflavin oxidoreductase activity|riboflavine mononucleotide reductase activity|riboflavin mononucleotide reductase activity|flavin mononucleotide reductase activity|flavine mononucleotide reductase activity|NAD(P)H:FMN oxidoreductase activity|NAD(P)H2 dehydrogenase (FMN) activity|NAD(P)H-FMN reductase activity|NAD(P)H2:FMN oxidoreductase activity|NAD(P)H-dependent FMN reductase activity EC:1.5.1.41|MetaCyc:RXN-12445|RHEA:31455|KEGG_REACTION:R09750 molecular_function owl:Class
GO:1900812 biolink:NamedThing helvolic acid biosynthetic process The chemical reactions and pathways resulting in the formation of helvolic acid. got7fsn_ti helvolic acid anabolism|Fumigacin biosynthesis|Fumigacin synthesis|Fumigacin anabolism|Fumigacin formation|helvolic acid synthesis|Fumigacin biosynthetic process|helvolic acid formation|helvolic acid biosynthesis di 2012-06-04T10:02:58Z biological_process owl:Class
GO:0042559 biolink:NamedThing pteridine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid. got7fsn_ti pteridine and derivative biosynthesis|pteridine-containing compound biosynthesis|pterin biosynthesis|pterin biosynthetic process|pteridine-containing compound formation|pteridine-containing compound synthesis|pteridine and derivative biosynthetic process|pteridine-containing compound anabolism biological_process owl:Class
GO:0072535 biolink:NamedThing tumor necrosis factor (ligand) superfamily member 11 production The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti tumor necrosis factor ligand superfamily member 11 production|RANKL production|TNFSF11 production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. mah 2011-01-14T01:42:23Z biological_process owl:Class
GO:1990294 biolink:NamedThing peptidyl-threonine trans-autophosphorylation The phosphorylation of a peptidyl-threonine to form peptidyl-O-phospho-L-threonine on an identical protein. For example, phosphorylation by the other kinase within a homodimer. got7fsn_ti al 2014-02-05T12:42:46Z biological_process owl:Class
GO:0046088 biolink:NamedThing cytidine biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine, cytosine riboside, a widely distributed nucleoside. got7fsn_ti cytidine synthesis|cytidine biosynthesis|cytidine anabolism|cytidine formation biological_process owl:Class
GO:0018222 biolink:NamedThing peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide. got7fsn_ti peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine|peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine|peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine|peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine|peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine RESID:AA0101 biological_process owl:Class
GO:0055048 biolink:NamedThing anastral spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart, in the absence of centrosomes. Formation is initiated by the nucleation of microtubules (MTs) in the vicinity of condensed chromatin. MTs then attach to and congress around the chromatin due to activity of microtubule motors. A bipolar spindle is formed by focusing of the terminal ends of the MT array into spindle poles by molecular motors and cross-linking proteins. got7fsn_ti biological_process owl:Class
GO:0103011 biolink:NamedThing mannosylfructose-phosphate synthase activity Catalysis of the reaction: GDP-alpha-D-mannose + beta-D-fructofuranose 6-phosphate <=> mannosylfructose-phosphate + GDP. got7fsn_ti RHEA:26039|EC:2.4.1.246|MetaCyc:RXN-9935 molecular_function owl:Class
GO:0090008 biolink:NamedThing hypoblast development The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast. got7fsn_ti tb 2009-07-29T10:25:54Z biological_process owl:Class
GO:0008692 biolink:NamedThing 3-hydroxybutyryl-CoA epimerase activity Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA. got7fsn_ti 3-hydroxybutanoyl-CoA 3-epimerase activity|3-hydroxyacyl-CoA epimerase activity|3-hydroxybutyryl coenzyme A epimerase activity EC:5.1.2.3|MetaCyc:OHBUTYRYL-COA-EPIM-RXN|RHEA:21760 molecular_function owl:Class
GO:0019031 biolink:NamedThing viral envelope The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins. got7fsn_ti viral glycoprotein|viral outside membrane Wikipedia:Viral_envelope cellular_component owl:Class
GO:0140261 biolink:NamedThing BCOR complex A protein-containing complex that monoubiquitinates histone H2A on K119, thus it facilitates the maintenance of the transcriptionally repressive state of some genes, such as BCL6. It consists of the corepressor BCOR or BCORL1, a Polycomb group (PcG) and a SCF ubiquitin ligase subcomplexes. In mammals, the core subunits of the complex include the PcG and PcG-associated proteins NSPC1, RING1, RNF2, and RYBP and the components of the SCF ubiquitin ligase, SKP1, and FBXL10. got7fsn_ti BCOR/BCORL1 complex|PRC1.1 complex|BCL6 corepressor (BCOR) complex|non-canonical BCOR-PRC1.1 complex|non-canonical PRC1-BCOR complex pg 2018-09-11T09:35:05Z cellular_component owl:Class
GO:0047219 biolink:NamedThing monoterpenol beta-glucosyltransferase activity Catalysis of the reaction: (-)-menthol + UDP-D-glucose = (-)-menthyl beta-D-glucoside + H(+) + UDP. got7fsn_ti UDP-glucose:(-)-menthol O-beta-D-glucosyltransferase activity|uridine diphosphoglucose-monoterpenol glucosyltransferase activity|UDPglucose:monoterpenol glucosyltransferase activity|UDPglucose:(-)-menthol O-beta-D-glucosyltransferase activity MetaCyc:2.4.1.127-RXN|EC:2.4.1.127|RHEA:11520|KEGG_REACTION:R02179 molecular_function owl:Class
GO:0047460 biolink:NamedThing L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate + H(2)O = 2-oxopent-4-enoate + chloride + H(+) + NH(4)(+). got7fsn_ti L-2-amino-4-chloropent-4-enoate chloride-lyase (deaminating)|L-2-amino-4-chloro-4-pentenoate dehalogenase activity|L-2-amino-4-chloropent-4-enoate chloride-lyase (adding H2O; deaminating; 2-oxopent-4-enoate-forming) MetaCyc:4.5.1.4-RXN|KEGG_REACTION:R02605|RHEA:11620|EC:4.5.1.4 molecular_function owl:Class
GO:0102436 biolink:NamedThing 7-methylmyricetin 4'-O-methyltransferase activity Catalysis of the reaction: 7-O-methylmyricetin + S-adenosyl-L-methionine <=> 7,4'-dimethylmyricetin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-13911 molecular_function owl:Class
GO:0018115 biolink:NamedThing peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine. got7fsn_ti peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine|peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine|peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine RESID:AA0223 biological_process owl:Class
GO:0004593 biolink:NamedThing pantothenase activity Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine. got7fsn_ti (R)-pantothenate amidohydrolase activity|pantothenate amidohydrolase activity|pantothenate hydrolase activity EC:3.5.1.22|MetaCyc:PANTOTHENASE-RXN|RHEA:12448|KEGG_REACTION:R02474 molecular_function owl:Class
GO:0061623 biolink:NamedThing glycolytic process from galactose The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP. got7fsn_ti dph 2014-04-28T08:13:38Z biological_process owl:Class
GO:0150087 biolink:NamedThing multiple synapse bouton, contacting single dendrite A single axon terminal bouton making contact onto two or more dendritic spines protruding from the same dendrite. got7fsn_ti MSB1|type 1 multiple-synapse bouton|type 1 multi-synapse bouton|type 1 multisynaptic bouton|type 1 multiple spine synapse bouton|type 1 multisynapse bouton|type 1 multi-synaptic bouton bc 2018-08-08T13:26:34Z cellular_component owl:Class
GO:0047802 biolink:NamedThing cysteine-conjugate transaminase activity Catalysis of the reaction: 2-oxoglutarate + S-(4-bromophenyl)-L-cysteine = (4-bromophenylsulfanyl)pyruvate + L-glutamate. got7fsn_ti S-(4-bromophenyl)-L-cysteine:2-oxoglutarate aminotransferase activity|cysteine-conjugate alpha-ketoglutarate transaminase (CAT-1)|cysteine conjugate aminotransferase activity RHEA:13485|MetaCyc:CYSTEINE-CONJUGATE-TRANSAMINASE-RXN|EC:2.6.1.75|KEGG_REACTION:R04338 molecular_function owl:Class
GO:0022022 biolink:NamedThing septal cell proliferation The multiplication or reproduction of septal cells, resulting in the expansion of a cell population. got7fsn_ti septum cell proliferation biological_process owl:Class
GO:0008260 biolink:NamedThing 3-oxoacid CoA-transferase activity Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA. got7fsn_ti 3-ketoacid CoA-transferase activity|succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity|acetoacetate succinyl-CoA transferase activity|succinyl-CoA:3-ketoacid-CoA transferase activity|succinyl-CoA:3-oxo-acid CoA-transferase activity|3-ketoacid coenzyme A transferase activity|3-oxoacid CoA dehydrogenase activity|succinyl-CoA transferase activity|3-oxo-CoA transferase activity|acetoacetyl coenzyme A-succinic thiophorase activity|3-oxoacid coenzyme A-transferase activity EC:2.8.3.5|RHEA:25480|Reactome:R-HSA-74177|MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN molecular_function owl:Class
GO:0070662 biolink:NamedThing mast cell proliferation The expansion of a mast cell population by cell division. got7fsn_ti mah 2009-05-28T05:27:51Z biological_process owl:Class
GO:0097011 biolink:NamedThing cellular response to granulocyte macrophage colony-stimulating factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus. got7fsn_ti cellular response to GM-CSF stimulus pr 2011-03-21T05:25:06Z biological_process owl:Class
GO:0033798 biolink:NamedThing thyroxine 5-deiodinase activity Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2. got7fsn_ti iodothyronine inner ring monodeiodinase activity|acceptor:3,3',5'-triiodo-L-thyronine oxidoreductase (iodinating) activity|inner ring-deiodinating pathway|diiodothyronine 5'-deiodinase activity|type III iodothyronine deiodinase activity|iodothyronine 5-deiodinase activity EC:1.21.99.3|MetaCyc:1.97.1.11-RXN|RHEA:18897 molecular_function owl:Class
GO:0005920 biolink:NamedThing smooth septate junction A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions. got7fsn_ti zonula continua cellular_component owl:Class
GO:0050591 biolink:NamedThing quinine 3-monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+). got7fsn_ti quinine 3-hydroxylase activity|nifedipine oxidase activity|quinine,NADPH:oxygen oxidoreductase activity EC:1.14.14.55|MetaCyc:1.14.13.67-RXN|KEGG_REACTION:R05727|RHEA:20149 molecular_function owl:Class
GO:0071308 biolink:NamedThing cellular response to menaquinone Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus. got7fsn_ti cellular response to menatetrenone|cellular response to vitamin K2 mah 2009-12-10T04:37:08Z biological_process owl:Class
GO:0102678 biolink:NamedThing 22-alpha-hydroxy-campest-4-en-3-one,NADPH:steroid 5alpha-reductase activity Catalysis of the reaction: (5alpha,22S,24R)-22-hydroxyergostan-3-one + NADP <=> H+ + (22S)-22-hydroxycampest-4-en-3-one + NADPH. got7fsn_ti MetaCyc:RXN-4229 molecular_function owl:Class
GO:0071192 biolink:NamedThing Kv4.2-KChIP1 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2. got7fsn_ti mah 2009-11-23T04:51:42Z CORUM:606 cellular_component owl:Class
GO:0032615 biolink:NamedThing interleukin-12 production The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL-12 production|interleukin-12 secretion|NKSF production|CLMF production|interleukin-12 biosynthetic process GO:0072610|GO:0042090 biological_process owl:Class
GO:1900353 biolink:NamedThing positive regulation of methanofuran biosynthetic process Any process that activates or increases the frequency, rate or extent of methanofuran biosynthetic process. got7fsn_ti up-regulation of methanofuran biosynthesis|up regulation of methanofuran biosynthetic process|up-regulation of methanofuran biosynthetic process|activation of methanofuran biosynthetic process|up regulation of methanofuran biosynthesis|upregulation of methanofuran biosynthetic process|upregulation of methanofuran biosynthesis|activation of methanofuran biosynthesis|positive regulation of methanofuran biosynthesis tt 2012-04-06T02:14:09Z biological_process owl:Class
GO:0047359 biolink:NamedThing 1-alkenyl-2-acylglycerol choline phosphotransferase activity Catalysis of the reaction: 1-alkenyl-2-acylglycerol + CDP-choline = plasmenylcholine + CMP. got7fsn_ti CDP-choline-1-alkenyl-2-acyl-glycerol phosphocholinetransferase activity|CDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity EC:2.7.8.22|MetaCyc:2.7.8.22-RXN|RHEA:21072 molecular_function owl:Class
GO:0102933 biolink:NamedThing GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase activity Catalysis of the reaction: GDP-4-amino-4,6-dideoxy-alpha-D-mannose + 2-oxoglutarate = GDP-4-dehydro-6-deoxy-alpha-D-mannose + L-glutamate. got7fsn_ti MetaCyc:RXN-8953|RHEA:36779|EC:2.6.1.102 molecular_function owl:Class
GO:0004676 biolink:NamedThing 3-phosphoinositide-dependent protein kinase activity Phosphatidylinositol-3-phosphate-dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. got7fsn_ti phosphatidylinositol-3-phosphate protein kinase activity|PDK activity This reaction requires the presence of a phosphatidylinositol-3-phosphate. Reactome:R-HSA-437195 molecular_function owl:Class
GO:0030272 biolink:NamedThing 5-formyltetrahydrofolate cyclo-ligase activity Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate. got7fsn_ti methenyl-THF synthetase activity|5,10-methenyltetrahydrofolate synthetase activity|5-formyltetrahydrofolate cyclodehydrase|5-Formyltetrahydrofolate cyclodehydrase activity|formyltetrahydrofolic cyclodehydrase activity|5-formyltetrahydrofolate cyclo-ligase (ADP-forming) GO:0019006 EC:6.3.3.2|Reactome:R-HSA-6801342|KEGG_REACTION:R02301|RHEA:10488|MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN molecular_function owl:Class
GO:0045209 biolink:NamedThing MAPK phosphatase export from nucleus, leptomycin B sensitive Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm. got7fsn_ti leptomycin B-sensitive MAPK phosphatase export out of nucleus|leptomycin B-sensitive MAPK phosphatase-nucleus export|leptomycin B-sensitive MAPK phosphatase transport from nucleus to cytoplasm|MAPK phosphatase transport from nucleus to cytoplasm, leptomycin B sensitive|MAPK phosphatase-nucleus export, leptomycin B sensitive|MAPK phosphatase export from cell nucleus, leptomycin B sensitive|MAPK phosphatase export out of nucleus, leptomycin B sensitive biological_process owl:Class
GO:0000252 biolink:NamedThing C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H. got7fsn_ti 3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity|sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity|3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)|C-3 sterol dehydrogenase (C-4 decarboxylase) activity|sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)|sterol 4alpha-carboxylic decarboxylase activity|3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)|C-3 sterol dehydrogenase activity|3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating) Note that zymosterol is cholesta-8,24-dien-3-ol. Reactome:R-HSA-194718|Reactome:R-HSA-194642|EC:1.1.1.170 molecular_function owl:Class
GO:0010768 biolink:NamedThing negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus. got7fsn_ti biological_process owl:Class
GO:0102215 biolink:NamedThing thiocyanate methyltransferase activity Catalysis of the reaction: thiocyanate + S-adenosyl-L-methionine <=> methyl thiocyanate + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:28014|MetaCyc:RXN-12189 molecular_function owl:Class
GO:0008904 biolink:NamedThing hygromycin-B 7''-O-phosphotransferase activity Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H(+). got7fsn_ti APH(7'') activity|hygromycin B kinase activity|destomic acid ring 7''-O-phosphotransferase activity|hygromycin-B kinase activity|hygromycin B phosphotransferase activity|ATP:hygromycin-B 7''-O-phosphotransferase activity EC:2.7.1.119|MetaCyc:HYGROMYCIN-B-KINASE-RXN|RHEA:23388|KEGG_REACTION:R03770 molecular_function owl:Class
GO:0060270 biolink:NamedThing main body follicle cell migration The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte. got7fsn_ti biological_process owl:Class
GO:0050085 biolink:NamedThing mannitol 2-dehydrogenase (NADP+) activity Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH. got7fsn_ti D-mannitol:NADP+ 2-oxidoreductase activity|NADP-dependent mannitol dehydrogenase activity RHEA:16765|MetaCyc:MANNITOL-2-DEHYDROGENASE-NADP+-RXN|KEGG_REACTION:R00870|EC:1.1.1.138 molecular_function owl:Class
GO:0050693 biolink:NamedThing LBD domain binding Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. got7fsn_ti ligand binding domain binding molecular_function owl:Class
GO:0004307 biolink:NamedThing ethanolaminephosphotransferase activity Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine. got7fsn_ti diacylglycerol ethanolaminephosphotransferase activity|CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity|phosphorylethanolamine-glyceride transferase activity|CDPethanolamine diglyceride phosphotransferase activity|EPT MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN|EC:2.7.8.1|RHEA:32943|Reactome:R-HSA-1482962 molecular_function owl:Class
GO:0044573 biolink:NamedThing nitrogenase P cluster assembly The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide. got7fsn_ti nitrogenase P cluster maturation|nitrogenase P cluster biosynthesis jl 2012-04-18T03:29:04Z biological_process owl:Class
GO:0019134 biolink:NamedThing glucosamine-1-phosphate N-acetyltransferase activity Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+). got7fsn_ti acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity|acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity EC:2.3.1.157|KEGG_REACTION:R05332|MetaCyc:2.3.1.157-RXN|RHEA:13725 molecular_function owl:Class
GO:0008489 biolink:NamedThing UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base. got7fsn_ti UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity|LacCer synthase activity|lactosylceramide synthase activity MetaCyc:RXN-10764 molecular_function owl:Class
GO:0099130 biolink:NamedThing estrogen binding Binding to an estrogen. got7fsn_ti molecular_function owl:Class
GO:0102644 biolink:NamedThing monocyclic sesterterpenediol synthase activity Catalysis of the reaction: monocyclic sesterterpenediol <=> all-trans-geranylfarnesol + H2O. got7fsn_ti MetaCyc:RXN-15756 molecular_function owl:Class
GO:0032533 biolink:NamedThing regulation of follicle cell microvillus length A process that modulates the length of a microvillus on a follicle cell. got7fsn_ti biological_process owl:Class
GO:0018103 biolink:NamedThing protein C-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom. got7fsn_ti protein amino acid C-linked glycosylation RESID:AA0217 biological_process owl:Class
GO:0031730 biolink:NamedThing CCR5 chemokine receptor binding Binding to a CCR5 chemokine receptor. got7fsn_ti CCR5 chemokine receptor ligand molecular_function owl:Class
GO:0042858 biolink:NamedThing chrysobactin biosynthetic process The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine). got7fsn_ti chrysobactin biosynthetic process, peptide modification|chrysobactin biosynthesis|chrysobactin biosynthetic process, peptide formation|chrysobactin synthesis|chrysobactin anabolism|chrysobactin formation GO:0031183|GO:0031184 biological_process owl:Class
GO:0034903 biolink:NamedThing endosulfan ether monooxygenase activity Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O. got7fsn_ti UM-BBD_reactionID:r1413 molecular_function owl:Class
GO:1990882 biolink:NamedThing rRNA acetylation The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. got7fsn_ti al 2015-10-28T13:24:58Z biological_process owl:Class
GO:0050445 biolink:NamedThing asparagusate reductase activity Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH. got7fsn_ti asparagusate reductase (NADH) activity|3-mercapto-2-mercaptomethylpropanoate:NAD+ oxidoreductase activity|NADH:asparagusate oxidoreductase activity|asparagusic dehydrogenase activity|asparagusate reductase (NADH2)|asparagusate dehydrogenase activity|NADH2:asparagusate oxidoreductase activity KEGG_REACTION:R03761|RHEA:14881|MetaCyc:ASPARAGUSATE-REDUCTASE-NADH-RXN|EC:1.8.1.11 molecular_function owl:Class
GO:0072707 biolink:NamedThing cellular response to sodium dodecyl sulfate Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus. got7fsn_ti cellular response to SDS mah 2012-04-11T03:35:15Z biological_process owl:Class
GO:0034406 biolink:NamedThing cell wall beta-glucan metabolic process The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of cells. got7fsn_ti cell wall beta-glucan metabolism biological_process owl:Class
GO:0050353 biolink:NamedThing trimethyllysine dioxygenase activity Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate. got7fsn_ti epsilon-trimethyllysine 2-oxoglutarate dioxygenase activity|TMLD activity|6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)|trimethyllysine,2-oxoglutarate dioxygenase activity|TML hydroxylase activity|TML-alpha-ketoglutarate dioxygenase activity|TML dioxygenase activity|trimethyllysine alpha-ketoglutarate dioxygenase activity|N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) KEGG_REACTION:R03451|RHEA:14181|EC:1.14.11.8|MetaCyc:TRIMETHYLLYSINE-DIOXYGENASE-RXN|Reactome:R-HSA-71241 molecular_function owl:Class
GO:0045975 biolink:NamedThing positive regulation of translation, ncRNA-mediated Any process, mediated by small non-coding RNAs, that activates or increases the rate that mRNAs are effectively translated into protein. got7fsn_ti up regulation of mRNA translation, ncRNA-mediated|upregulation of mRNA translation, ncRNA-mediated|up-regulation of mRNA translation, ncRNA-mediated|activation of mRNA translation, ncRNA-mediated|stimulation of mRNA translation, ncRNA-mediated biological_process owl:Class
GO:1990435 biolink:NamedThing upper tip-link density An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends. got7fsn_ti UTLD sl 2014-07-30T16:36:32Z cellular_component owl:Class
GO:0090204 biolink:NamedThing protein localization to nuclear pore A process in which a protein is transported to, or maintained in, a nuclear pore. got7fsn_ti protein localisation to nuclear pore tb 2009-12-18T12:05:01Z biological_process owl:Class
GO:0004322 biolink:NamedThing ferroxidase activity Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O. got7fsn_ti HEPH|iron(II): oxygen oxidoreductase activity|caeruloplasmin|hephaestin|ceruloplasmin|ferroxidase, iron II:oxygen oxidoreductase activity|ferro:O2 oxidoreductase activity|Fe(II):oxygen oxidoreductase activity|ferroxidase I|multicopper ferroxidase iron transport mediator activity https://github.com/geneontology/go-ontology/issues/20675 RHEA:11148|Reactome:R-HSA-1562603|Reactome:R-HSA-5621402|EC:1.16.3.1|Reactome:R-HSA-917891|MetaCyc:RXN0-1483|Reactome:R-HSA-917933|Reactome:R-HSA-1562604|Reactome:R-HSA-5691107|Reactome:R-HSA-1562626 molecular_function owl:Class
GO:0010048 biolink:NamedThing vernalization response The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures. got7fsn_ti biological_process owl:Class
GO:1990142 biolink:NamedThing envenomation resulting in hemolysis in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with hemolysis in the bitten organism. got7fsn_ti sp 2013-07-18T10:46:03Z biological_process owl:Class
GO:0008908 biolink:NamedThing isochorismatase activity Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate. got7fsn_ti isochorismate pyruvate-hydrolase activity|2,3-dihydroxy-2,3-dihydrobenzoate synthase activity|2,3-dihydro-2,3-dihydroxybenzoate synthase activity|2,3 dihydro-2,3 dihydroxybenzoate synthase activity|2,3-dihydroxy-2,3-dihydrobenzoic synthase activity KEGG_REACTION:R03037|RHEA:11112|EC:3.3.2.1|MetaCyc:ISOCHORMAT-RXN molecular_function owl:Class
GO:1901510 biolink:NamedThing (-)-microperfuranone metabolic process The chemical reactions and pathways involving (-)-microperfuranone. got7fsn_ti (-)-microperfuranone metabolism di 2012-10-18T06:54:10Z biological_process owl:Class
GO:0060867 biolink:NamedThing fruit abscission The controlled shedding of a fruit. got7fsn_ti dph 2009-08-12T06:35:28Z biological_process owl:Class
GO:0071820 biolink:NamedThing N-box binding Binding to an N-box, a DNA motif with the consensus sequence CACNAG that is found in the promoters of genes expressed preferentially at synapses. got7fsn_ti N box binding|N-box promoter binding Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. mah 2010-09-07T11:55:32Z molecular_function owl:Class
GO:0004491 biolink:NamedThing methylmalonate-semialdehyde dehydrogenase (acylating) activity Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. got7fsn_ti 2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)|MSDH activity|MMSA dehydrogenase activity EC:1.2.1.27|MetaCyc:1.2.1.27-RXN|RHEA:20804|Reactome:R-HSA-70893 molecular_function owl:Class
GO:0015298 biolink:NamedThing solute:cation antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out). got7fsn_ti molecular_function owl:Class
GO:0003386 biolink:NamedThing amphid sensory organ development The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes. got7fsn_ti dph 2009-12-09T09:09:20Z biological_process owl:Class
GO:0010179 biolink:NamedThing IAA-Ala conjugate hydrolase activity Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine. got7fsn_ti MetaCyc:RXN-2981 molecular_function owl:Class
GO:0090067 biolink:NamedThing regulation of thalamus size Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus. got7fsn_ti tb 2009-09-02T11:03:03Z biological_process owl:Class
GO:0072174 biolink:NamedThing metanephric tubule formation The developmental process pertaining to the initial formation of a metanephric tubule. got7fsn_ti mah 2010-02-26T02:07:41Z biological_process owl:Class
GO:0102339 biolink:NamedThing 3-oxo-arachidoyl-CoA reductase activity Catalysis of the reaction: (R)-3-hydroxyicosanoyl-CoA(4-) + NADP(3-) <=> 3-oxoicosanoyl-CoA + NADPH + H+. got7fsn_ti EC:1.1.1.330|MetaCyc:RXN-13298 molecular_function owl:Class
GO:0060001 biolink:NamedThing minus-end directed microfilament motor activity A motor activity that generates movement along a microfilament towards the minus end, driven by ATP hydrolysis. The minus end of an actin filament is the end that does not preferentially add actin monomers. got7fsn_ti minus-end directed actin filament motor activity|pointed-end directed actin-filament motor activity|minus-end directed actin-filament motor activity molecular_function owl:Class
GO:0106355 biolink:NamedThing 4-hydroxybenzoate 3-monooxygenase [NADH] activity Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+. got7fsn_ti hjd 2021-02-02T05:51:36Z RHEA:19473 molecular_function owl:Class
GO:0004082 biolink:NamedThing bisphosphoglycerate mutase activity Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate. got7fsn_ti DPGM|bisphosphoglyceromutase|3-phospho-D-glycerate 1,2-phosphomutase activity|2,3-bisphosphoglycerate mutase activity|BPGM activity|2,3-bisphosphoglycerate synthase activity|diphosphoglyceric mutase activity|bisphosphoglycerate synthase activity|biphosphoglycerate synthase activity|2,3-diphosphoglycerate mutase activity|diphosphoglycerate mutase activity|glycerate phosphomutase activity|diphosphoglyceromutase activity|2,3-diphosphoglyceromutase activity|2,3-diphosphoglycerate synthase activity EC:5.4.2.4|MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN|Reactome:R-HSA-6798335|RHEA:17765 molecular_function owl:Class
GO:0048242 biolink:NamedThing epinephrine secretion The regulated release of epinephrine by a cell. Epinephrine is a catecholamine hormone secreted by the adrenal medulla and a neurotransmitter, released by certain neurons and active in the central nervous system. got7fsn_ti adrenaline secretion biological_process owl:Class
GO:0050180 biolink:NamedThing phloretin hydrolase activity Catalysis of the reaction: H(2)O + phloretin = H(+) + phloretate + phloroglucinol. got7fsn_ti lactase-phlorizin hydrolase|2',4,4',6'-tetrahydroxydehydrochalcone 1,3,5-trihydroxybenzenehydrolase activity MetaCyc:PHLORETIN-HYDROLASE-RXN|RHEA:23396|EC:3.7.1.4|KEGG_REACTION:R02901 molecular_function owl:Class
GO:0102943 biolink:NamedThing trans-2,3-dihydro-3-hydroxy-anthranilate isomerase activity Catalysis of the reaction: (2S,3S)-2,3-dihydro-3-hydroxyanthranilic acid = (1R,6S)-6-ammonio-5-oxocyclohex-2-ene-1-carboxylate. got7fsn_ti EC:5.3.3.17|MetaCyc:RXN-9031|RHEA:28182 molecular_function owl:Class
GO:0018896 biolink:NamedThing dibenzothiophene catabolic process The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. got7fsn_ti dibenzothiophene breakdown|dibenzothiophene catabolism|dibenzothiophene degradation UM-BBD_pathwayID:dbt2 biological_process owl:Class
GO:0003856 biolink:NamedThing 3-dehydroquinate synthase activity Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate. got7fsn_ti RHEA:21968|MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN|EC:4.2.3.4|KEGG_REACTION:R03083 molecular_function owl:Class
GO:0050847 biolink:NamedThing progesterone receptor signaling pathway Any series of molecular signals generated as a consequence of a progesterone binding to its receptor. got7fsn_ti progesterone receptor signalling pathway biological_process owl:Class
GO:0102349 biolink:NamedThing trans-lignocero-2-enoyl-CoA reductase activity Catalysis of the reaction: tetracosanoyl-CoA + NADP <=> trans-2-tetracosenoyl-CoA + NADPH + H+. got7fsn_ti MetaCyc:RXN-13308 molecular_function owl:Class
GO:0034024 biolink:NamedThing glutamate-putrescine ligase activity Catalysis of the reaction: L-glutamate + ATP + putrescine = gamma-L-glutamylputrescine + ADP + 2 H(+) + phosphate. got7fsn_ti YcjK|gamma-glutamylputrescine synthetase activity|L-glutamate:putrescine ligase (ADP-forming) activity RHEA:13633|EC:6.3.1.11|MetaCyc:RXN0-3901|KEGG_REACTION:R07414 molecular_function owl:Class
GO:0098036 biolink:NamedThing viral DNA genome packaging, 3' extended cos packaging The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 3' protruding ends. got7fsn_ti bm 2012-07-20T11:38:40Z biological_process owl:Class
GO:0050853 biolink:NamedThing B cell receptor signaling pathway A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. got7fsn_ti B-lymphocyte receptor signalling pathway|B cell receptor signalling pathway|B-cell receptor signaling pathway|B-lymphocyte receptor signaling pathway|B lymphocyte receptor signalling pathway|B-cell receptor signalling pathway|B lymphocyte receptor signaling pathway biological_process owl:Class
GO:0008566 biolink:NamedThing mitochondrial protein-transporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex. got7fsn_ti ATPase-coupled mitochondrial protein transporter activity See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. EC:7.4.2.3|MetaCyc:3.6.3.51-RXN molecular_function owl:Class
GO:0070408 biolink:NamedThing carbamoyl phosphate metabolic process The chemical reactions and pathways involving carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways. got7fsn_ti carbamoyl phosphate metabolism UM-BBD_pathwayID:bzn biological_process owl:Class
GO:0071602 biolink:NamedThing phytosphingosine biosynthetic process The chemical reactions and pathways resulting in the formation of phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol. got7fsn_ti phytosphingosine biosynthesis|phytosphingosine synthesis|phytosphingosine anabolism|phytosphingosine formation mah 2010-02-04T05:15:59Z biological_process owl:Class
GO:0071284 biolink:NamedThing cellular response to lead ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. got7fsn_ti mah 2009-12-10T04:00:41Z biological_process owl:Class
GO:0061463 biolink:NamedThing O-acetyl-ADP-ribose deacetylase activity Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate. got7fsn_ti dph 2012-10-05T11:05:06Z molecular_function owl:Class
GO:0070768 biolink:NamedThing synaptotagmin-synaptobrevin 2-SNAP-25-syntaxin-1a-syntaxin-1b-Unc13 complex A SNARE complex that contains synaptotagmin, synaptobrevin 2 (VAMP2), SNAP-25, syntaxin 1a, syntaxin1b, and Unc13b (or orthologs thereof). got7fsn_ti Snap25-Syt1-Unc13b-Vamp2-Stx1b2-Stx1a complex|SNARE complex (Snap25, Syt1, Unc13b, Vamp2, Stx1b2, Stx1a) mah 2009-06-29T05:14:04Z cellular_component owl:Class
GO:0034696 biolink:NamedThing response to prostaglandin F Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin F stimulus. got7fsn_ti response to prostaglandin F stimulus biological_process owl:Class
GO:0034733 biolink:NamedThing transcription factor TFIIIB-beta complex A transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and BRF, and is involved in the regulation of transcription from type 2 RNA polymerase III promoters. got7fsn_ti Note that the subunits of TFIIIB-beta are conserved between human and yeast; however, in yeast a single TFIIIB complex regulates transcription of tRNA, 5S rRNA and U6 snRNA genes, whereas two different TBP-dependent TFIIIB activities exist in humans. cellular_component owl:Class
GO:0019678 biolink:NamedThing propionate metabolic process, methylmalonyl pathway The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway. got7fsn_ti propionate metabolism, methylmalonyl pathway MetaCyc:PROPIONMET-PWY biological_process owl:Class
GO:0080062 biolink:NamedThing cytokinin 9-beta-glucosyltransferase activity Catalysis of the reaction: 6-alkylaminopurine + UDP-D-glucose = 6-alkylamino-9-beta-D-glucosylpurine + H+ + UDP. This reaction is an N-glucosylation event. got7fsn_ti dhl 2009-04-13T03:34:38Z KEGG_REACTION:R08369 molecular_function owl:Class
GO:0047054 biolink:NamedThing berbamunine synthase activity Catalysis of the reaction: (S)-N-methylcoclaurine + (R)-N-methylcoclaurine + [reduced NADPH--hemoprotein reductase] + O2 <=> berbamunine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. got7fsn_ti heme-thiolate https://github.com/geneontology/go-ontology/issues/21133 EC:1.14.19.66|MetaCyc:1.1.3.34-RXN|RHEA:23576 molecular_function owl:Class
GO:0002006 biolink:NamedThing vasoconstriction by vasopressin involved in systemic arterial blood pressure control The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream. got7fsn_ti vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control biological_process owl:Class
GO:0047514 biolink:NamedThing 1,3-beta-D-glucan phosphorylase activity Catalysis of the reaction: [(1->3)-beta-D-glucosyl](n) + phosphate = [(1->3)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate; substrates include laminarin. got7fsn_ti 1,3-beta-D-glucan:orthophosphate glucosyltransferase activity|laminarin phosphorylase activity|1,3-beta-D-glucan:phosphate alpha-D-glucosyltransferase activity|laminarin phosphoryltransferase activity|1,3-beta-glucan phosphorylase activity EC:2.4.1.97|MetaCyc:13-BETA-GLUCAN-PHOSPHORYLASE-RXN molecular_function owl:Class
GO:0036078 biolink:NamedThing minus-end specific microtubule depolymerization The removal of tubulin heterodimers from the minus end of a microtubule. got7fsn_ti bf 2011-12-19T03:20:25Z biological_process owl:Class
GO:0042184 biolink:NamedThing xylene catabolic process The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene. got7fsn_ti xylene breakdown|xylene degradation|xylene catabolism biological_process owl:Class
GO:0060371 biolink:NamedThing regulation of atrial cardiac muscle cell membrane depolarization Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. got7fsn_ti regulation of atrial cardiomyocyte membrane depolarization|regulation of atrial cardiac muscle cell depolarization|electrocardiogram PR interval|atrial depolarization biological_process owl:Class
GO:0103036 biolink:NamedThing NADH:menaquinone oxidoreductase activity Catalysis of the reaction: 5 H+ + NADH + a menaquinone <=> 4 H+ + NAD + a menaquinol. got7fsn_ti MetaCyc:RXN0-5388 molecular_function owl:Class
GO:0030647 biolink:NamedThing aminoglycoside antibiotic metabolic process The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin. got7fsn_ti aminoglycoside antibiotic metabolism biological_process owl:Class
GO:0045904 biolink:NamedThing negative regulation of translational termination Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination. got7fsn_ti inhibition of translational termination|down-regulation of translational termination|downregulation of translational termination|down regulation of translational termination biological_process owl:Class
GO:0004021 biolink:NamedThing L-alanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate. got7fsn_ti L-alanine-alpha-ketoglutarate aminotransferase activity|ALT|pyruvate-alanine aminotransferase activity|glutamic--pyruvic transaminase activity|pyruvate-glutamate transaminase activity|glutamic-pyruvic aminotransferase activity|pyruvate transaminase activity|alanine-pyruvate aminotransferase activity|GPT|L-alanine transaminase activity|glutamic acid-pyruvic acid transaminase activity|glutamic--alanine transaminase activity|beta-alanine aminotransferase|alanine-alpha-ketoglutarate aminotransferase activity|alanine aminotransferase activity|alanine transaminase activity|L-alanine aminotransferase activity Reactome:R-HSA-507749|Reactome:R-HSA-70524|KEGG_REACTION:R00258|Reactome:R-HSA-507775|EC:2.6.1.2|MetaCyc:ALANINE-AMINOTRANSFERASE-RXN|Reactome:R-HSA-70523|RHEA:19453 molecular_function owl:Class
GO:0042731 biolink:NamedThing PH domain binding Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. got7fsn_ti molecular_function owl:Class
GO:0008569 biolink:NamedThing minus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis. got7fsn_ti dynein ATPase|ATP-dependent minus-end-directed microtubule motor activity|microtubule motor activity, minus-end-directed|kinesin ATP phosphohydrolase (minus-end-directed)|minus-end-directed kinesin ATPase activity|minus-end-directed ATP-dependent microtubule motor activity|ATP-dependent microtubule motor activity, minus-end-directed https://github.com/geneontology/go-ontology/issues/21289|https://github.com/geneontology/go-ontology/issues/18664 MetaCyc:3.6.4.5-RXN|EC:5.6.1.2|EC:5.6.1.4 molecular_function owl:Class
GO:0031879 biolink:NamedThing type 2 somatostatin receptor binding Binding to a type 2 somatostatin receptor. got7fsn_ti type 2 somatostatin receptor ligand molecular_function owl:Class
GO:0103031 biolink:NamedThing L-Ala-D/L-Glu epimerase activity Catalysis of the reaction: L-alanyl-D-glutamate = L-alanyl-L-glutamate. got7fsn_ti MetaCyc:RXN0-5228|RHEA:28394 molecular_function owl:Class
GO:0008903 biolink:NamedThing hydroxypyruvate isomerase activity Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate. got7fsn_ti hydroxypyruvate ketol-isomerase activity|hydroxypyruvate aldose-ketose-isomerase activity EC:5.3.1.22|KEGG_REACTION:R01394|RHEA:11952|MetaCyc:RXN0-305 molecular_function owl:Class
GO:0034545 biolink:NamedThing fumarylpyruvate hydrolase activity Catalysis of the reaction: fumarylpyruvate + H2O = fumarate + pyruvate + H+. got7fsn_ti RHEA:26168|EC:3.7.1.20|UM-BBD_reactionID:r0811 molecular_function owl:Class
GO:0003873 biolink:NamedThing 6-phosphofructo-2-kinase activity Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+). got7fsn_ti 6-phosphofructo-2-kinase (phosphorylating)|ATP:D-fructose-6-phosphate 2-phosphotransferase activity|6-phosphofructose 2-kinase activity|fructose 6-phosphate 2-kinase activity|phosphofructokinase 2 activity|ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity EC:2.7.1.105|Reactome:R-HSA-71802|KEGG_REACTION:R02732|MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN|RHEA:15653 molecular_function owl:Class
GO:0008650 biolink:NamedThing rRNA (uridine-2'-O-)-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine. got7fsn_ti Reactome:R-HSA-6793127 molecular_function owl:Class
GO:0008701 biolink:NamedThing 4-hydroxy-2-oxovalerate aldolase activity Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate. got7fsn_ti 4-hydroxy-2-ketovalerate aldolase activity|DmpG|4-hydroxy-2-oxopentanoate pyruvate-lyase activity|HOA|4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity|4-hydroxy-2-oxovalerate pyruvate-lyase activity GO:0018804 KEGG_REACTION:R00750|RHEA:22624|EC:4.1.3.39|UM-BBD_enzymeID:e0077|MetaCyc:MHPELY-RXN molecular_function owl:Class
GO:0047748 biolink:NamedThing cholestanetetraol 26-dehydrogenase activity Catalysis of the reaction: 5-beta-cholestane-3-alpha,7-alpha,12-alpha,26-tetraol + NAD+ = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-al + NADH. got7fsn_ti cholestanetetrol 26-dehydrogenase activity|5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity|5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase activity|TEHC-NAD oxidoreductase activity RHEA:34631|MetaCyc:CHOLESTANETETRAOL-26-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0140605 biolink:NamedThing proton motive force-driven motor activity A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella. got7fsn_ti proton motive force-driven motor activity https://github.com/geneontology/go-ontology/issues/19590 pg 2021-02-17T08:04:50Z molecular_function owl:Class
GO:0032222 biolink:NamedThing regulation of synaptic transmission, cholinergic Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine. got7fsn_ti biological_process owl:Class
GO:0043804 biolink:NamedThing imidazolone hydrolase activity Catalysis of the reaction: N-formimidoylglycine => H2O + imidazol-4-one. got7fsn_ti Note that this reaction can occur spontaneously (see RHEA:24937). RHEA:24935 molecular_function owl:Class
GO:0097375 biolink:NamedThing spinal sensory neuron axon guidance The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord. got7fsn_ti pr 2012-10-01T10:17:20Z biological_process owl:Class
GO:0099629 biolink:NamedThing postsynaptic specialization of symmetric synapse A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses. got7fsn_ti postsynaptic density of inhibitory synapse cellular_component owl:Class
GO:0050156 biolink:NamedThing ornithine N-benzoyltransferase activity Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+). got7fsn_ti ornithine N-acyltransferase activity|benzoyl-CoA:L-ornithine N-benzoyltransferase activity EC:2.3.1.127|KEGG_REACTION:R00664|RHEA:16929|MetaCyc:ORNITHINE-N-BENZOYLTRANSFERASE-RXN molecular_function owl:Class
GO:1990400 biolink:NamedThing mitochondrial ribosomal large subunit rRNA binding Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA). got7fsn_ti mitochondrial LSU rRNA binding|21S rRNA binding In S. cerevisiae, this is the mitochondrial 21S rRNA mcc 2014-06-23T16:47:09Z molecular_function owl:Class
GO:0071943 biolink:NamedThing Myc-Max complex A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max. got7fsn_ti mah 2010-10-01T11:56:17Z cellular_component owl:Class
GO:0052055 biolink:NamedThing modulation by symbiont of host molecular function The process in which an organism effects a change in the function of a host protein via a direct interaction. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modification by symbiont of host protein function|modification by symbiont of host molecular function biological_process owl:Class
GO:0120030 biolink:NamedThing positive regulation of cilium beat frequency involved in ciliary motility Any process that activates or increases the frequency of cilium beating involved in ciliary motility. got7fsn_ti krc 2017-04-19T14:32:16Z biological_process owl:Class
GO:0070443 biolink:NamedThing Mad-Max complex A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max. got7fsn_ti cellular_component owl:Class
GO:0047831 biolink:NamedThing D-ornithine 4,5-aminomutase activity Catalysis of the reaction: D-ornithine = (2R,4S)-2,4-diaminopentanoate. got7fsn_ti D-alpha-ornithine 5,4-aminomutase activity|D-ornithine aminomutase activity EC:5.4.3.5|RHEA:14893|KEGG_REACTION:R02461|MetaCyc:ORNMUTST-RXN molecular_function owl:Class
GO:0102187 biolink:NamedThing 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity Catalysis of the reaction: 4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol + NAD(1-) <=> 4alpha,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3-one + NADH(2-) + carbon dioxide. got7fsn_ti MetaCyc:RXN-11949 molecular_function owl:Class
GO:0034560 biolink:NamedThing bisphenol A hydroxylase A activity Catalysis of the reaction: bisphenol A + NADH + H+ + O2 = 2,2-bis(4-hydroxyphenyl)-1-propanol + NAD+ + H2O. got7fsn_ti EC:1.14.13.-|UM-BBD_reactionID:r0861 molecular_function owl:Class
GO:0102859 biolink:NamedThing 1-18:1-2-18:2-phosphatidylcholine desaturase activity (SN2-18:3 forming) Catalysis of the reaction: 1-18:1-2-18:2-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:1-2-18:3-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti EC:1.14.19.25|RHEA:46404|MetaCyc:RXN-8326 molecular_function owl:Class
GO:0034482 biolink:NamedThing chondroitin 2-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 2'-O-sulfate. Results in sulfation of glucuronic acid and iduronic acid residues. got7fsn_ti chondroitin 2-sulfotransferase activity|chondroitin 2-O-sulphotransferase activity molecular_function owl:Class
GO:0044485 biolink:NamedThing envenomation resulting in fibrinogenolysis in other organism The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism. got7fsn_ti jl 2012-01-26T03:41:01Z biological_process owl:Class
GO:0019809 biolink:NamedThing spermidine binding Binding to spermidine, N-(3-aminopropyl)-1,4-diaminobutane. got7fsn_ti molecular_function owl:Class
GO:0019808 biolink:NamedThing polyamine binding Binding to a polyamine, an organic compound containing two or more amino groups. got7fsn_ti molecular_function owl:Class
GO:0097417 biolink:NamedThing nematosome Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles. got7fsn_ti pr 2012-11-06T16:47:56Z NIF_Subcellular:sao138430598 cellular_component owl:Class
GO:0102714 biolink:NamedThing gibberellin A12,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A12 + 2-oxoglutarate + O2 <=> gibberellin A14 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-6544 molecular_function owl:Class
GO:0086071 biolink:NamedThing atrial cardiac muscle cell-AV node cell adhesion involved in cell communication The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate. got7fsn_ti atrial cardiomyocyte-AV node cell adhesion involved in cell communication|atrial cardiomyocyte-atrioventricular node cell adhesion involved in cell communication dph 2011-11-22T09:46:33Z biological_process owl:Class
GO:0102202 biolink:NamedThing soladodine glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + solasodine <=> UDP + solasodine 3-O-beta-D-glucopyranoside + H+. got7fsn_ti RHEA:61844|EC:2.4.1.173|MetaCyc:RXN-12123 molecular_function owl:Class
GO:0047511 biolink:NamedThing (S)-methylmalonyl-CoA hydrolase activity Catalysis of the reaction: (S)-methylmalonyl-CoA + H(2)O = CoA + H(+) + methylmalonate. got7fsn_ti D-methylmalonyl-coenzyme A hydrolase activity KEGG_REACTION:R02764|EC:3.1.2.17|MetaCyc:S-METHYLMALONYL-COA-HYDROLASE-RXN|RHEA:17345 molecular_function owl:Class
GO:0061795 biolink:NamedThing Golgi lumen acidification Any process that reduces the pH of the Golgi lumen, measured by the concentration of the hydrogen ion. got7fsn_ti dph 2016-10-05T08:42:40Z biological_process owl:Class
GO:0035640 biolink:NamedThing exploration behavior The specific behavior of an organism in response to a novel environment or stimulus. got7fsn_ti exploratory behaviour|exploration behaviour|open-field behavior|exploratory behavior For changes in locomotory behavior upon introduction to a novel environment, consider instead the child term: locomotory exploration behavior ; GO:0035641. bf 2011-01-19T10:35:45Z biological_process owl:Class
GO:0045231 biolink:NamedThing slime layer organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. got7fsn_ti slime layer organization and biogenesis|slime layer organisation biological_process owl:Class
GO:0046428 biolink:NamedThing 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + polyprenylpyrophosphate = dimethylmenaquinone + diphosphate + CO2. got7fsn_ti 1,4-Dihydroxy-2-naphtoate prenyltransferase activity RHEA:30099|MetaCyc:DMK-RXN|EC:2.5.1.74 molecular_function owl:Class
GO:0047320 biolink:NamedThing D-4-hydroxyphenylglycine transaminase activity Catalysis of the reaction: 2-oxoglutarate + D-4-hydroxyphenylglycine = 4-hydroxyphenylglyoxylate + L-glutamate. got7fsn_ti D-hydroxyphenylglycine aminotransferase activity|D-4-hydroxyphenylglycine aminotransferase activity|D-4-hydroxyphenylglycine:2-oxoglutarate aminotransferase activity EC:2.6.1.72|KEGG_REACTION:R04234|MetaCyc:2.6.1.72-RXN|RHEA:15589 molecular_function owl:Class
GO:0140641 biolink:NamedThing mitotic spindle formation (spindle phase two) The spindle organization process in which the spindle is maintained at a constant length during mitotic metaphase. got7fsn_ti metaphase spindle stability|metaphase spindle stabilization https://github.com/geneontology/go-ontology/issues/21349 pg 2021-05-11T08:15:15Z biological_process owl:Class
GO:0061565 biolink:NamedThing dAMP phosphorylation The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP. got7fsn_ti dph 2013-08-01T12:50:38Z biological_process owl:Class
GO:0018905 biolink:NamedThing dimethyl ether metabolic process The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications. got7fsn_ti methyl ether metabolic process|methyl ether metabolism|dimethyl ether metabolism UM-BBD_pathwayID:dme biological_process owl:Class
GO:0033591 biolink:NamedThing response to L-ascorbic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an L-ascorbic acid (vitamin C) stimulus. got7fsn_ti response to L-ascorbate|response to ascorbic acid|response to vitamin C biological_process owl:Class
GO:0071661 biolink:NamedThing regulation of granzyme B production Any process that modulates the frequency, rate, or extent of production of granzyme B. got7fsn_ti mah 2010-02-12T10:41:14Z biological_process owl:Class
GO:0001817 biolink:NamedThing regulation of cytokine production Any process that modulates the frequency, rate, or extent of production of a cytokine. got7fsn_ti regulation of cytokine anabolism|regulation of cytokine formation|regulation of cytokine synthesis|regulation of cytokine biosynthetic process|regulation of cytokine secretion|regulation of cytokine biosynthesis GO:0042035|GO:0050707 biological_process owl:Class
GO:0070530 biolink:NamedThing K63-linked polyubiquitin modification-dependent protein binding Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein. got7fsn_ti molecular_function owl:Class
GO:0001940 biolink:NamedThing male pronucleus The pronucleus originating from the spermatozoa that was involved in fertilization. got7fsn_ti cellular_component owl:Class
GO:0047009 biolink:NamedThing 3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity Catalysis of the reaction: NAD+ + 3-alpha-hydroxy-5-beta-androstane-17-one = NADH + H+ + 5-beta-androstane-3,17-dione. got7fsn_ti 3alpha-hydroxy-5beta-steroid dehydrogenase activity|3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase activity|3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase activity|etiocholanolone 3alpha-dehydrogenase activity|etiocholanolone 3-alpha-dehydrogenase activity EC:1.1.1.152|RHEA:10356|MetaCyc:1.1.1.152-RXN molecular_function owl:Class
GO:0106300 biolink:NamedThing protein-DNA covalent cross-linking repair The removal of covalent cross-link between DNA and a protein. got7fsn_ti resolution of protein-DNA covalent cross-linking hjd 2020-08-26T14:23:42Z biological_process owl:Class
GO:0033737 biolink:NamedThing 1-pyrroline dehydrogenase activity Catalysis of the reaction: 1-pyrroline + NAD+ + 2 H2O = 4-aminobutanoate + NADH + 2 H+. got7fsn_ti ABALDH|YdcW|1-pyrroline:NAD+ oxidoreductase activity|gamma-aminobutyraldehyde dehydrogenase activity MetaCyc:1.5.1.35-RXN|EC:1.2.1.19 molecular_function owl:Class
GO:0031471 biolink:NamedThing ethanolamine degradation polyhedral organelle An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase. got7fsn_ti ethanolamine metabolosome cellular_component owl:Class
GO:0035785 biolink:NamedThing cellular nickel ion homeostasis Any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell. got7fsn_ti cellular nickel homeostasis bf 2011-04-05T09:55:56Z biological_process owl:Class
GO:0016589 biolink:NamedThing NURF complex An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters. got7fsn_ti nucleosome remodeling factor complex cellular_component owl:Class
GO:0031086 biolink:NamedThing nuclear-transcribed mRNA catabolic process, deadenylation-independent decay A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability. got7fsn_ti mRNA catabolism, deadenylation-independent decay|mRNA catabolic process, deadenylylation-independent|mRNA catabolic process, deadenylation-independent|mRNA catabolism, deadenylation-independent|mRNA catabolism, deadenylylation-independent|mRNA degradation, deadenylation-independent decay|mRNA breakdown, deadenylation-independent decay|nuclear mRNA catabolic process, deadenylation-independent decay|deadenylation-independent mRNA decay|deadenylylation-independent mRNA decay biological_process owl:Class
GO:0044655 biolink:NamedThing phagosome reneutralization Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation. got7fsn_ti phagosomal reneutralization|phagosome pH elevation jl 2012-07-26T04:21:14Z biological_process owl:Class
GO:0051454 biolink:NamedThing intracellular pH elevation Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion. got7fsn_ti cell pH elevation|intracellular alkalinization|pH elevation in cell|cellular alkalinization|elevation of cellular pH biological_process owl:Class
GO:0009815 biolink:NamedThing 1-aminocyclopropane-1-carboxylate oxidase activity Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O(2) = CO(2) + dehydroascorbate + ethylene + 2 H(2)O + hydrogen cyanide. Ethene is also known as ethylene. got7fsn_ti 1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)|ethene-forming enzyme|ACC oxidase activity|ethylene-forming enzyme|aminocyclopropanecarboxylate oxidase activity KEGG_REACTION:R07214|EC:1.14.17.4|RHEA:23640|MetaCyc:ETHYL-RXN molecular_function owl:Class
GO:0061576 biolink:NamedThing acyl-CoA ceramide synthase complex A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1. got7fsn_ti dph 2013-10-24T14:42:06Z cellular_component owl:Class
GO:0071926 biolink:NamedThing endocannabinoid signaling pathway The series of molecular signals generated as a consequence of an endocannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Endocannabinoids are small molecules derived from arachidonic acid, anandamide (arachidonoylethanolamide) and 2-arachidonoylglycerol. got7fsn_ti endocannabinoid signalling pathway mah 2010-09-28T11:52:03Z biological_process owl:Class
GO:0034390 biolink:NamedThing smooth muscle cell apoptotic process Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. got7fsn_ti programmed cell death of smooth muscle cells by apoptosis|apoptosis of smooth muscle cells|SMC apoptosis|smooth muscle cell programmed cell death by apoptosis|programmed cell death, smooth muscle cells|smooth muscle cell apoptosis biological_process owl:Class
GO:0098997 biolink:NamedThing fusion of virus membrane with host outer membrane Fusion of a viral membrane with the host cell outer membrane during viral entry. got7fsn_ti viral envelope fusion|fusion of viral membrane with host outer membrane|viral-cell fusion molecule activity|viral penetration via membrane fusion|viral envelope fusion with host outer membrane VZ:3941 biological_process owl:Class
GO:0102286 biolink:NamedThing ornithine N-delta-acetyltransferase activity Catalysis of the reaction: L-ornithinium(1+) = N(5)-acetyl-L-ornithine. got7fsn_ti MetaCyc:RXN-12667 molecular_function owl:Class
GO:0003939 biolink:NamedThing L-iditol 2-dehydrogenase activity Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+. got7fsn_ti sorbitol dehydrogenase activity|L-iditol:NAD oxidoreductase activity|NAD-dependent sorbitol dehydrogenase activity|glucitol dehydrogenase activity|NAD-sorbitol dehydrogenase|L-iditol (sorbitol) dehydrogenase activity|L-iditol:NAD+ 5-oxidoreductase activity|NAD+-dependent sorbitol dehydrogenase activity|polyol dehydrogenase activity Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols. MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN|EC:1.1.1.14|RHEA:10160|Reactome:R-HSA-5652195 molecular_function owl:Class
GO:0034013 biolink:NamedThing aliphatic aldoxime dehydratase activity Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O. got7fsn_ti OxdA|aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity|aliphatic aldoxime hydro-lyase activity EC:4.99.1.5|MetaCyc:4.99.1.5-RXN|RHEA:11316 molecular_function owl:Class
GO:0046576 biolink:NamedThing rhamnogalacturonan alpha-L-rhamnopyranosyl-(1->4)-alpha-D-galactopyranosyluronide lyase activity Catalysis of the cleavage of rhamnogalacturonan, generating oligosaccharides of the form alpha-D-us-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,4)-alpha-D-galacturonate-(1,2)-L-rhamnose-(1,2)-alpha-L-rhamnose-p-(1,4)-alpha-D-galacturonic acid, terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue. got7fsn_ti rhamnogalacturonase B activity molecular_function owl:Class
GO:0106073 biolink:NamedThing dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity Catalysis of the addition of the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. got7fsn_ti hjd 2017-11-28T19:16:37Z RHEA:29543|EC:2.4.1.256 molecular_function owl:Class
GO:0035711 biolink:NamedThing T-helper 1 cell activation The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. got7fsn_ti Th1 cell activation bf 2011-03-02T03:05:08Z biological_process owl:Class
GO:0043422 biolink:NamedThing protein kinase B binding Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. got7fsn_ti Akt binding|PKB binding molecular_function owl:Class
GO:1900815 biolink:NamedThing monodictyphenone biosynthetic process The chemical reactions and pathways resulting in the formation of monodictyphenone. got7fsn_ti monodictyphenone synthesis|monodictyphenone anabolism|monodictyphenone biosynthesis|monodictyphenone formation di 2012-06-04T10:11:35Z biological_process owl:Class
GO:0030341 biolink:NamedThing chondroitin AC lyase activity Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups. got7fsn_ti chondroitin lyase activity|chondroitin AC eliminase activity|chondroitin sulfate lyase activity|chondroitinase AC|ChnAC|chondroitinase activity EC:4.2.2.5|MetaCyc:4.2.2.5-RXN molecular_function owl:Class
GO:0002158 biolink:NamedThing osteoclast proliferation The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. got7fsn_ti hjd 2010-02-03T01:50:37Z biological_process owl:Class
GO:2001028 biolink:NamedThing positive regulation of endothelial cell chemotaxis Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis. got7fsn_ti rl 2011-08-22T01:07:34Z biological_process owl:Class
GO:0009088 biolink:NamedThing threonine biosynthetic process The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. got7fsn_ti threonine formation|threonine anabolism|threonine biosynthesis|threonine synthesis MetaCyc:THRESYN-PWY|MetaCyc:HOMOSER-THRESYN-PWY biological_process owl:Class
GO:0047227 biolink:NamedThing indolylacetyl-myo-inositol galactosyltransferase activity Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-D-galactose = 5-O-(indol-3-ylacetyl)-myo-inositol D-galactoside + H(+) + UDP. got7fsn_ti UDP-galactose:(indol-3-yl)acetyl-myo-inositol 5-O-D-galactosyltransferase activity|uridine diphosphogalactose-indolylacetylinositol galactosyltransferase activity|UDP-galactose:indol-3-ylacetyl-myo-inositol 5-O-D-galactosyltransferase activity|indol-3-ylacetyl-myo-inositol galactoside synthase activity KEGG_REACTION:R04334|MetaCyc:2.4.1.156-RXN|EC:2.4.1.156|RHEA:21148 molecular_function owl:Class
GO:0047947 biolink:NamedThing glutamine N-phenylacetyltransferase activity Catalysis of the reaction: phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine. got7fsn_ti glutamine phenylacetyltransferase activity|phenylacetyl-CoA:L-glutamine N-acetyltransferase activity|phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase activity MetaCyc:GLUTAMINE-N-PHENYLACETYLTRANSFERASE-RXN|EC:2.3.1.14|RHEA:21844 molecular_function owl:Class
GO:0016057 biolink:NamedThing regulation of membrane potential in photoreceptor cell Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon. got7fsn_ti changes in polarization state of photoreceptor cell membrane biological_process owl:Class
GO:0052662 biolink:NamedThing zeaxanthin epoxidase activity Catalysis of the reaction: all-trans-zeaxanthin + 4 H+ + 2 O2 + 4 reduced [2Fe-2S]-[ferredoxin] = all-trans-violaxanthin + 2 H2O + 4 oxidized [2Fe-2S]-[ferredoxin]. got7fsn_ti zeaxanthin epoxidase [overall] activity|antheraxanthin epoxidase activity|zea-epoxidase activity https://github.com/geneontology/go-ontology/issues/21412 Multi-step reaction: RHEA:14937 and RHEA:24084. Formerly EC:1.14.13.90. GO:0052663|GO:0009540 KEGG_REACTION:R07200|KEGG_REACTION:R06946|KEGG_REACTION:R06947|KEGG_REACTION:R07199|EC:1.14.15.21|RHEA:24084|MetaCyc:RXN-7978|MetaCyc:RXN-7979 molecular_function owl:Class
GO:0039521 biolink:NamedThing suppression by virus of host autophagy Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host. got7fsn_ti inhibition by virus of host autophagy|negative regulation by virus of host autophagy|inhibition of host autophagy by virus bf 2011-06-22T04:30:11Z VZ:845 biological_process owl:Class
GO:0019010 biolink:NamedThing farnesoic acid O-methyltransferase activity Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine. got7fsn_ti S-adenosyl-methionine:farnesoic acid O-methyltransferase activity molecular_function owl:Class
GO:0035520 biolink:NamedThing monoubiquitinated protein deubiquitination The removal of the ubiquitin group from a monoubiquitinated protein. got7fsn_ti monoubiquitinated protein deubiquitinylation|monoubiquitinated protein deubiquitylation bf 2010-05-04T04:28:38Z biological_process owl:Class
GO:0047449 biolink:NamedThing 2-dehydro-3-deoxy-L-arabinonate dehydratase activity Catalysis of the reaction: 2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H(2)O. got7fsn_ti 2-dehydro-3-deoxy-L-arabinonate hydro-lyase activity|2-dehydro-3-deoxy-L-arabinonate hydro-lyase (2,5-dioxopentanoate-forming)|2-keto-3-deoxy-L-arabinonate dehydratase activity EC:4.2.1.43|KEGG_REACTION:R02278|MetaCyc:4.2.1.43-RXN|RHEA:17201 molecular_function owl:Class
GO:0098001 biolink:NamedThing receptor-mediated bacteriophage reversible attachment to host cell Process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection. got7fsn_ti phage reversible adsorption|reversible bacteriophage attachment, binding of host cell surface receptor This process was historically defined by the release, by Waring blending or sonication, by dilution and centrifugation, or by filtration and washing, of infective virions from their complexes with cells, thus contrary to what is observed after irreversible adsorption. bm biological_process owl:Class
GO:0016153 biolink:NamedThing urocanate hydratase activity Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O. got7fsn_ti 3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)|3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity|imidazolonepropionate hydrolase activity|urocanase activity KEGG_REACTION:R02914|Reactome:R-HSA-70903|RHEA:13101|MetaCyc:UROCANATE-HYDRATASE-RXN|EC:4.2.1.49 molecular_function owl:Class
GO:0050060 biolink:NamedThing long-chain-alcohol dehydrogenase activity Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH. got7fsn_ti fatty alcohol oxidoreductase activity|long-chain-alcohol:NAD+ oxidoreductase activity|long-chain alcohol dehydrogenase activity RHEA:17977|EC:1.1.1.192|MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0071196 biolink:NamedThing Kv4.3-KChIP1 channel complex A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3. got7fsn_ti mah 2009-11-23T04:59:38Z CORUM:3091 cellular_component owl:Class
GO:0016270 biolink:NamedThing O-glycan processing, core 4 The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc. got7fsn_ti biological_process owl:Class
GO:0098592 biolink:NamedThing cytoplasmic side of apical plasma membrane The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm. got7fsn_ti dos 2014-03-06T12:07:32Z cellular_component owl:Class
GO:0031880 biolink:NamedThing type 3 somatostatin receptor binding Binding to a type 3 somatostatin receptor. got7fsn_ti type 3 somatostatin receptor ligand molecular_function owl:Class
GO:0070058 biolink:NamedThing tRNA gene clustering The process in which tRNA genes, which are not linearly connected on the chromosome, are transported in three dimensions to, and maintained together in, the nucleolus. This clustered positioning leads to transcriptional silencing of nearby RNA polymerase II promoters (termed tRNA gene mediated (tgm) silencing) in S. cerevisiae. got7fsn_ti biological_process owl:Class
GO:0019854 biolink:NamedThing L-ascorbic acid catabolic process The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions. got7fsn_ti L-ascorbic acid breakdown|vitamin C catabolic process|ascorbate catabolic process|L-ascorbic acid catabolism|L-ascorbic acid degradation|vitamin C catabolism|ascorbate catabolism MetaCyc:PWY0-301 biological_process owl:Class
GO:0052578 biolink:NamedThing alpha-farnesene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = (E,E)-alpha-farnesene + diphosphate. got7fsn_ti (E,E)-alpha-farnesene synthase activity ai 2010-08-09T01:39:42Z MetaCyc:RXN-8574|RHEA:27421 molecular_function owl:Class
GO:0004420 biolink:NamedThing hydroxymethylglutaryl-CoA reductase (NADPH) activity Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH. got7fsn_ti HMG-CoA reductase activity|3-hydroxy-3-methylglutaryl-coenzyme A reductase activity|hydroxymethylglutaryl-CoA reductase activity https://github.com/geneontology/go-ontology/issues/21411 GO:0042282 Reactome:R-HSA-191352|KEGG_REACTION:R02082|EC:1.1.1.34|RHEA:15989|MetaCyc:1.1.1.34-RXN molecular_function owl:Class
GO:0003938 biolink:NamedThing IMP dehydrogenase activity Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+. got7fsn_ti IMP oxidoreductase activity|inosine monophosphate dehydrogenase activity|inosine 5'-monophosphate dehydrogenase activity|inosinic acid dehydrogenase activity|IMP:NAD+ oxidoreductase activity|inosinate dehydrogenase activity|inosine monophosphate oxidoreductase activity|inosine-5'-phosphate dehydrogenase activity EC:1.1.1.205|MetaCyc:IMP-DEHYDROG-RXN|Reactome:R-HSA-73794|RHEA:11708 molecular_function owl:Class
GO:0034281 biolink:NamedThing ent-isokaurene synthase activity Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate. got7fsn_ti molecular_function owl:Class
GO:0002952 biolink:NamedThing (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione. got7fsn_ti phospho-AI-2 isomerase activity molecular_function owl:Class
GO:0021975 biolink:NamedThing pons reticulospinal tract morphogenesis Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord. got7fsn_ti biological_process owl:Class
GO:0030941 biolink:NamedThing chloroplast targeting sequence binding Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast. got7fsn_ti molecular_function owl:Class
GO:0032142 biolink:NamedThing single guanine insertion binding Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine. got7fsn_ti molecular_function owl:Class
GO:0097317 biolink:NamedThing invasive growth in response to biotic stimulus The growth of colonies in filamentous chains of cells as a result of a biotic stimulus. An example of this is Candida albicans forming invasive filaments in agar medium in response to a serum stimulus. got7fsn_ti pr 2012-05-31T10:38:16Z biological_process owl:Class
GO:0070850 biolink:NamedThing TACC/TOG complex A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase. got7fsn_ti mah 2009-08-05T03:06:08Z cellular_component owl:Class
GO:1900719 biolink:NamedThing regulation of uterine smooth muscle relaxation Any process that modulates the frequency, rate or extent of uterine smooth muscle relaxation. got7fsn_ti regulation of smooth muscle relaxation of the uterus jl 2012-05-24T03:12:26Z biological_process owl:Class
GO:0021858 biolink:NamedThing GABAergic neuron differentiation in basal ganglia The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron. got7fsn_ti biological_process owl:Class
GO:0018701 biolink:NamedThing 2,5-dichlorohydroquinone reductive dehalogenase activity Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone). got7fsn_ti EC:1.97.1.-|UM-BBD_enzymeID:e0366 molecular_function owl:Class
GO:1990412 biolink:NamedThing hercynylselenocysteine lyase activity (selenoneine-forming) Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium. got7fsn_ti mah 2014-07-02T15:51:07Z RHEA:42696 molecular_function owl:Class
GO:0006532 biolink:NamedThing aspartate biosynthetic process The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid. got7fsn_ti aspartate biosynthesis|aspartate anabolism|aspartate formation|aspartate synthesis biological_process owl:Class
GO:0050629 biolink:NamedThing tetrachloroethene reductive dehalogenase activity Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor. got7fsn_ti tetrachloroethene reductase activity|acceptor:trichloroethene oxidoreductase (chlorinating) MetaCyc:1.97.1.8-RXN|RHEA:20353|EC:1.21.99.5 molecular_function owl:Class
GO:0061367 biolink:NamedThing behavioral response to acetic acid induced pain Any process that results in a change in the behaviour of an organism as a result of an acetic acid pain stimulus. got7fsn_ti dph 2010-10-21T03:26:31Z biological_process owl:Class
GO:0033838 biolink:NamedThing flavonol-3-O-glucoside glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside. got7fsn_ti UDP-glucose:flavonol-3-O-glucoside 2''-O-beta-D-glucosyltransferase activity EC:2.4.1.239|RHEA:18893|MetaCyc:2.4.1.239-RXN molecular_function owl:Class
GO:0103067 biolink:NamedThing 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NAD(P) = 5alpha-cholesta-8-en-3-one + carbon dioxide + NAD(P)H. got7fsn_ti RHEA:33447|EC:1.1.1.170|MetaCyc:RXN66-23 molecular_function owl:Class
GO:1900801 biolink:NamedThing cspyrone B1 catabolic process The chemical reactions and pathways resulting in the breakdown of cspyrone B1. got7fsn_ti cspyrone B1 breakdown|cspyrone B1 catabolism|cspyrone B1 degradation di 2012-06-04T09:50:58Z biological_process owl:Class
GO:0019283 biolink:NamedThing L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine. got7fsn_ti L-methionine anabolism from O-phospho-L-homoserine and cystathionine|L-methionine formation from O-phospho-L-homoserine and cystathionine|L-methionine synthesis from O-phospho-L-homoserine and cystathionine|methionine biosynthetic process from O-phospho-L-homoserine and cystathionine biological_process owl:Class
GO:0070220 biolink:NamedThing aerobic sulfur oxidation A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur dioxygenase, and requires the presence of oxygen. got7fsn_ti aerobic sulphur oxidation MetaCyc:SULFUROX-PWY biological_process owl:Class
GO:0030589 biolink:NamedThing pseudocleavage involved in syncytial blastoderm formation Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster. got7fsn_ti pseudocleavage during syncytial blastoderm formation biological_process owl:Class
GO:0033391 biolink:NamedThing chromatoid body A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). got7fsn_ti cellular_component owl:Class
GO:0046197 biolink:NamedThing orcinol biosynthetic process The chemical reactions and pathways resulting in the formation of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants. got7fsn_ti orcinol formation|orcinol biosynthesis|orcinol anabolism|orcinol synthesis biological_process owl:Class
GO:0001198 biolink:NamedThing negative regulation of mating-type specific transcription from RNA polymerase II promoter Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter. got7fsn_ti down regulation of RNA polymerase II transcription, mating-type specific|down-regulation of RNA polymerase II transcription, mating-type specific|inhibition of RNA polymerase II transcription, mating-type specific|downregulation of RNA polymerase II transcription, mating-type specific krc 2011-11-23T09:36:06Z biological_process owl:Class
GO:0070579 biolink:NamedThing methylcytosine dioxygenase activity Catalysis of the reaction: methylcytosine + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine + succinate + CO2. got7fsn_ti mah 2009-04-22T02:29:41Z Reactome:R-HSA-5221014|Reactome:R-HSA-5220952|Reactome:R-HSA-5220990 molecular_function owl:Class
GO:0004347 biolink:NamedThing glucose-6-phosphate isomerase activity Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. got7fsn_ti phosphohexoisomerase activity|D-glucose-6-phosphate ketol-isomerase activity|phosphohexose isomerase activity|glucose phosphate isomerase activity|hexose monophosphate isomerase activity|phosphosaccharomutase activity|oxoisomerase activity|hexosephosphate isomerase activity|phosphohexomutase activity|phosphoglucoisomerase activity|D-glucose-6-phosphate aldose-ketose-isomerase activity|phosphoglucose isomerase activity|hexose phosphate isomerase activity RHEA:11816|Reactome:R-HSA-70471|Reactome:R-HSA-70475|EC:5.3.1.9|MetaCyc:PGLUCISOM-RXN molecular_function owl:Class
GO:0032399 biolink:NamedThing HECT domain binding Binding to a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein. got7fsn_ti molecular_function owl:Class
GO:0008831 biolink:NamedThing dTDP-4-dehydrorhamnose reductase activity Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH. got7fsn_ti dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity|dTDP-4-keto-L-rhamnose reductase activity|thymidine diphospho-4-ketorhamnose reductase activity|dTDP-4-ketorhamnose reductase activity|dTDP-6-deoxy-L-mannose dehydrogenase activity|TDP-4-keto-rhamnose reductase activity|reductase, thymidine diphospho-4-ketorhamnose MetaCyc:DTDPDEHYRHAMREDUCT-RXN|EC:1.1.1.133|KEGG_REACTION:R02777|RHEA:21796 molecular_function owl:Class
GO:0045521 biolink:NamedThing interleukin-25 receptor binding Binding to an interleukin-25 receptor. got7fsn_ti interleukin-25 receptor ligand|IL-25 molecular_function owl:Class
GO:0060793 biolink:NamedThing sweat gland placode formation The developmental process in which the sweat gland placode forms. An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud. got7fsn_ti dph 2009-08-04T12:38:10Z biological_process owl:Class
GO:0033457 biolink:NamedThing GAU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GAU codon. got7fsn_ti GAT codon-amino acid adaptor activity|aspartic acid tRNA Note that in the standard genetic code, GAT codes for aspartic acid. molecular_function owl:Class
GO:1900817 biolink:NamedThing ochratoxin A catabolic process The chemical reactions and pathways resulting in the breakdown of ochratoxin A. got7fsn_ti Ochratoxin A breakdown|Ochratoxin A degradation|ochratoxin A degradation|Ochratoxin A catabolic process|ochratoxin A breakdown|ochratoxin A catabolism|Ochratoxin A catabolism di 2012-06-04T10:13:26Z biological_process owl:Class
GO:0034268 biolink:NamedThing discadenine biosynthetic process The chemical reactions and pathways resulting in the formation of discadenine, (2S)-2-amino-4-{6-[(3-methylbut-2-en-1-yl)amino]-3H-purin-3-yl}butanoic acid. got7fsn_ti discadenine biosynthesis|discadenine formation|discadenine anabolism|discadenine synthesis biological_process owl:Class
GO:0090560 biolink:NamedThing 2-(3-amino-3-carboxypropyl)histidine synthase activity Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]. got7fsn_ti tb 2014-03-27T14:58:50Z RHEA:36783|Reactome:R-HSA-5358494|MetaCyc:RXN-11371 molecular_function owl:Class
GO:0010540 biolink:NamedThing basipetal auxin transport The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root. got7fsn_ti biological_process owl:Class
GO:0103042 biolink:NamedThing 4-hydroxy-L-threonine aldolase activity Catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine. got7fsn_ti RHEA:28779|MetaCyc:RXN0-6563 molecular_function owl:Class
GO:0047819 biolink:NamedThing D-glutamate(D-aspartate) oxidase activity Catalysis of the reaction: D-glutamate + H2O + O2 = 2-oxoglutarate + NH3 + H2O2, and D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2. got7fsn_ti D-glutamate(D-aspartate):oxygen oxidoreductase (deaminating)|D-glutamic-aspartic oxidase activity|D-monoaminodicarboxylic acid oxidase activity For the individual reactions, see instead 'D-glutamate oxidase activity ;GO:0047821' and 'D-aspartate oxidase activity ; GO:0008445'. EC:1.4.3.15|MetaCyc:D-GLUTAMATED-ASPARTATE-OXIDASE-RXN molecular_function owl:Class
GO:0047335 biolink:NamedThing 3-phosphoglyceroyl-phosphate-polyphosphate phosphotransferase activity Catalysis of the reaction: long-chain-polyphosphate + 3-phospho-D-glyceroyl-phosphate = long-chain-polyphosphate + 3-phosphoglycerate. got7fsn_ti 1,3-diphosphoglycerate-polyphosphate phosphotransferase activity|diphosphoglycerate-polyphosphate phosphotransferase activity|3-phospho-D-glyceroyl-phosphate:polyphosphate phosphotransferase activity RHEA:18665|MetaCyc:2.7.4.17-RXN|EC:2.7.4.17 molecular_function owl:Class
GO:0044088 biolink:NamedThing regulation of vacuole organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. got7fsn_ti regulation of vacuole organisation|regulation of vacuole biogenesis biological_process owl:Class
GO:0016258 biolink:NamedThing N-glycan diversification The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases. got7fsn_ti biological_process owl:Class
GO:0008070 biolink:NamedThing maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line. got7fsn_ti maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded|maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded biological_process owl:Class
GO:0062050 biolink:NamedThing GPI-mannose ethanolamine phosphate phosphodiesterase activity A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor. got7fsn_ti dph 2018-06-01T18:26:54Z molecular_function owl:Class
GO:0050569 biolink:NamedThing glycolaldehyde dehydrogenase activity Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH. got7fsn_ti glycol aldehyde dehydrogenase activity|glycolaldehyde:NAD+ oxidoreductase activity EC:1.2.1.21|RHEA:20001|MetaCyc:GLYCOLALD-DEHYDROG-RXN|KEGG_REACTION:R01333 molecular_function owl:Class
GO:0061481 biolink:NamedThing response to TNF agonist Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus. got7fsn_ti dph 2012-11-07T09:14:07Z biological_process owl:Class
GO:0036485 biolink:NamedThing dorsolateral trunk neural crest cell migration The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells. got7fsn_ti dorsolateral trunk NCC migration bf 2014-08-26T15:29:04Z biological_process owl:Class
GO:0033504 biolink:NamedThing floor plate development The progression of the floor plate over time from its initial formation until its mature state. got7fsn_ti biological_process owl:Class
GO:0046280 biolink:NamedThing chalcone catabolic process The chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives. got7fsn_ti chalcone breakdown|chalcone catabolism|chalcone degradation biological_process owl:Class
GO:0046271 biolink:NamedThing phenylpropanoid catabolic process The chemical reactions and pathways resulting in the breakdown of aromatic derivatives of trans-cinnamic acid. got7fsn_ti phenylpropanoid degradation|phenylpropanoid catabolism|phenylpropanoid breakdown biological_process owl:Class
GO:0075279 biolink:NamedThing uredinium development The process that leads to the formation of a uredinium, a reddish, pustule-like structure formed by a rust fungus and consisting of uredospores. got7fsn_ti development of uredium biological_process owl:Class
GO:0030084 biolink:NamedThing PSI associated light-harvesting complex I, LHCIb subcomplex A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm. got7fsn_ti cellular_component owl:Class
GO:0033908 biolink:NamedThing beta-L-rhamnosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-L-rhamnose residues in beta-L-rhamnosides. got7fsn_ti beta-L-rhamnoside rhamnohydrolase activity MetaCyc:3.2.1.43-RXN|EC:3.2.1.43 molecular_function owl:Class
GO:0008847 biolink:NamedThing Enterobacter ribonuclease activity Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. got7fsn_ti Enterobacter RNase activity|enterobacter ribonuclease activity EC:4.6.1.21|MetaCyc:3.1.27.6-RXN molecular_function owl:Class
GO:0010430 biolink:NamedThing fatty acid omega-oxidation A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation. got7fsn_ti MetaCyc:PWY-2724 biological_process owl:Class
GO:0051274 biolink:NamedThing beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-glucans. got7fsn_ti beta-glucan synthesis|beta-glucan formation|beta-glucan biosynthesis|beta-glucan anabolism biological_process owl:Class
GO:0030927 biolink:NamedThing manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site. got7fsn_ti RESID:AA0366 biological_process owl:Class
GO:0009836 biolink:NamedThing fruit ripening, climacteric A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset. got7fsn_ti biological_process owl:Class
GO:0120239 biolink:NamedThing vascular endothelial glycocalyx The carbohydrate-rich layer lining the vascular endothelium connected to the endothelium through a variety of molecules, mainly proteoglycans and glycoproteins. These form a network in which soluble molecules, either plasma- or endothelium-derived, are incorporated. got7fsn_ti endothelial glycocalyx https://github.com/geneontology/go-ontology/issues/19782 krc 2020-07-27T21:55:41Z cellular_component owl:Class
GO:0006438 biolink:NamedThing valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0044815 biolink:NamedThing DNA packaging complex A protein complex that plays a role in the process of DNA packaging. got7fsn_ti jl 2013-09-19T11:33:45Z cellular_component owl:Class
GO:0018621 biolink:NamedThing 4-sulfobenzoate 3,4-dioxygenase activity Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite. got7fsn_ti 4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)|4-sulfobenzoate 3,4-dioxygenase system|4-sulfobenzoate dioxygenase activity|4-sulphobenzoate 3,4-dioxygenase activity EC:1.14.12.8|KEGG_REACTION:R01636|UM-BBD_reactionID:r0293|MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN|RHEA:13937 molecular_function owl:Class
GO:0000171 biolink:NamedThing ribonuclease MRP activity Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA. got7fsn_ti RNase MRP Wikipedia:RNase_MRP molecular_function owl:Class
GO:0042767 biolink:NamedThing ecdysteroid 22-hydroxylase activity Catalysis of the hydroxylation of an ecdysteroid at carbon position 22. got7fsn_ti Note that in the ecdysteroidogenic pathway, this activity catalyzes the conversion of 2,22-dideoxyecdysone (ketotriol) to 2-deoxyecdysone. molecular_function owl:Class
GO:0004062 biolink:NamedThing aryl sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. got7fsn_ti phenol sulfokinase activity|phenol sulfotransferase activity|p-nitrophenol sulfotransferase activity|dopamine sulfotransferase activity|arylsulfotransferase|sulfokinase activity|aryl sulphotransferase activity|4-nitrocatechol sulfokinase activity|1-naphthol phenol sulfotransferase activity|PST|ritodrine sulfotransferase activity|2-naphtholsulfotransferase activity|3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity Reactome:R-HSA-158860|Reactome:R-HSA-158849|MetaCyc:ARYL-SULFOTRANSFERASE-RXN|Reactome:R-HSA-176585|EC:2.8.2.1|RHEA:12164|Reactome:R-HSA-159358|Reactome:R-HSA-158468|Reactome:R-HSA-176646|Reactome:R-HSA-176474 molecular_function owl:Class
GO:0045029 biolink:NamedThing G protein-coupled UDP receptor activity Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP. got7fsn_ti UDP-activated nucleotide receptor activity molecular_function owl:Class
GO:0050387 biolink:NamedThing urethanase activity Catalysis of the reaction: H(2)O + H(+) + urethane = CO(2) + ethanol + NH(4)(+). got7fsn_ti urethane hydrolase activity|urethane amidohydrolase (decarboxylating) RHEA:21372|MetaCyc:URETHANASE-RXN|EC:3.5.1.75|KEGG_REACTION:R02359 molecular_function owl:Class
GO:0002409 biolink:NamedThing Langerhans cell chemotaxis The movement of a Langerhans cell in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0033192 biolink:NamedThing calmodulin-dependent protein phosphatase activity Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. got7fsn_ti Ca2+/CaM-dependent protein phosphatase activity|calcineurin activity|calcium- and calmodulin-dependent protein phosphatase activity|calcium/calmodulin-dependent protein phosphatase activity Reactome:R-HSA-4551451|Reactome:R-HSA-2730849 molecular_function owl:Class
GO:0034988 biolink:NamedThing Fc-gamma receptor I complex binding Binding to one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG. got7fsn_ti molecular_function owl:Class
GO:0052794 biolink:NamedThing exo-alpha-(2->3)-sialidase activity Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates. got7fsn_ti exo-alpha-(2,3)-sialidase activity|exo-alpha-2,3-sialidase activity EC:3.2.1.18 molecular_function owl:Class
GO:0035133 biolink:NamedThing post-embryonic caudal fin morphogenesis The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion. got7fsn_ti biological_process owl:Class
GO:0050914 biolink:NamedThing sensory perception of salty taste The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. got7fsn_ti salty taste perception biological_process owl:Class
GO:0102444 biolink:NamedThing isorhamnetin 3-O-methyltransferase activity Catalysis of the reaction: isorhamnetin + S-adenosyl-L-methionine <=> 3,3'-dimethylquercetin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13929 molecular_function owl:Class
GO:0044090 biolink:NamedThing positive regulation of vacuole organization Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole. got7fsn_ti positive regulation of vacuole biogenesis|positive regulation of vacuole organisation biological_process owl:Class
GO:0007298 biolink:NamedThing border follicle cell migration The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster. got7fsn_ti border cell migration biological_process owl:Class
GO:2000047 biolink:NamedThing regulation of cell-cell adhesion mediated by cadherin Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin. got7fsn_ti jl 2010-08-20T12:56:44Z biological_process owl:Class
GO:0047037 biolink:NamedThing salutaridine reductase (NADPH) activity Catalysis of the reaction: (7S)-salutaridinol + NADP(+) = H(+) + NADPH + salutaridine. got7fsn_ti salutaridinol:NADP+ 7-oxidoreductase activity KEGG_REACTION:R04697|MetaCyc:1.1.1.248-RXN|EC:1.1.1.248|RHEA:10108 molecular_function owl:Class
GO:1903304 biolink:NamedThing positive regulation of pyruvate kinase activity Any process that activates or increases the frequency, rate or extent of pyruvate kinase activity. got7fsn_ti positive regulation of phosphoenol transphosphorylase activity|up-regulation of phosphoenolpyruvate kinase activity|up-regulation of pyruvate kinase activity|upregulation of pyruvate kinase activity|up-regulation of ATP:pyruvate 2-O-phosphotransferase activity|upregulation of phosphoenolpyruvate kinase activity|activation of ATP:pyruvate 2-O-phosphotransferase activity|upregulation of ATP:pyruvate 2-O-phosphotransferase activity|activation of phosphoenolpyruvate kinase activity|activation of phosphoenol transphosphorylase activity|up regulation of phosphoenolpyruvate kinase activity|positive regulation of ATP:pyruvate 2-O-phosphotransferase activity|up regulation of phosphoenol transphosphorylase activity|up regulation of ATP:pyruvate 2-O-phosphotransferase activity|up regulation of pyruvate kinase activity|upregulation of phosphoenol transphosphorylase activity|activation of pyruvate kinase activity|positive regulation of phosphoenolpyruvate kinase activity|up-regulation of phosphoenol transphosphorylase activity mr 2014-08-15T23:26:06Z biological_process owl:Class
GO:0051347 biolink:NamedThing positive regulation of transferase activity Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. got7fsn_ti upregulation of transferase activity|up-regulation of transferase activity|stimulation of transferase activity|transferase activator|up regulation of transferase activity|activation of transferase activity This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. biological_process owl:Class
GO:0032638 biolink:NamedThing interleukin-9 production The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-9 biosynthetic process|IL-9 production|interleukin-9 secretion GO:0042229|GO:0072607 biological_process owl:Class
GO:0047993 biolink:NamedThing hydroxymalonate dehydrogenase activity Catalysis of the reaction: hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate. got7fsn_ti hydroxymalonate:NAD+ oxidoreductase activity EC:1.1.1.167|KEGG_REACTION:R02969|MetaCyc:HYDROXYMALONATE-DEHYDROGENASE-RXN|RHEA:11284 molecular_function owl:Class
GO:0050035 biolink:NamedThing L-sorbose oxidase activity Catalysis of the reaction: L-sorbose + O(2) = 5-dehydro-D-fructose + H(2)O(2). got7fsn_ti L-sorbose:oxygen 5-oxidoreductase activity RHEA:17853|KEGG_REACTION:R01695|EC:1.1.3.11|MetaCyc:L-SORBOSE-OXIDASE-RXN molecular_function owl:Class
GO:0035837 biolink:NamedThing ergot alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of an ergot alkaloid. got7fsn_ti ergot alkaloid formation|ergot alkaloid biosynthesis|ergot alkaloid anabolism|ergot alkaloid synthesis bf 2011-05-04T03:23:57Z biological_process owl:Class
GO:0008934 biolink:NamedThing inositol monophosphate 1-phosphatase activity Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. got7fsn_ti myo-inositol-1-phosphatase activity|myo-inositol-1(or 4)-phosphate phosphohydrolase activity|L-myo-inositol-1-phosphate phosphatase activity|myo-inositol 1-phosphatase activity|inositol 1-phosphatase activity|inositol-1(or 4)-monophosphatase activity|myo-inositol-1(or 4)-monophosphatase activity MetaCyc:RXN0-5408|RHEA:27670|EC:3.1.3.25|Reactome:R-HSA-1855154 molecular_function owl:Class
GO:0044155 biolink:NamedThing host caveola A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti jl 2009-08-11T04:00:55Z cellular_component owl:Class
GO:0002277 biolink:NamedThing myeloid dendritic cell activation involved in immune response The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. got7fsn_ti myeloid dendritic cell activation during immune response biological_process owl:Class
GO:0050534 biolink:NamedThing 3-deoxyoctulosonase activity Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide. got7fsn_ti 3-deoxyoctulosonyl-lipopolysaccharide hydrolase activity|alpha-Kdo-ase activity MetaCyc:3.2.1.144-RXN|EC:3.2.1.144 molecular_function owl:Class
GO:0097516 biolink:NamedThing microvillar actin bundle A parallel bundle of actin filaments at the core of a microvillus. got7fsn_ti pr 2013-10-16T15:12:13Z cellular_component owl:Class
GO:2000692 biolink:NamedThing negative regulation of seed maturation Any process that stops, prevents or reduces the frequency, rate or extent of seed maturation. got7fsn_ti dhl 2011-05-13T06:41:43Z biological_process owl:Class
GO:0016133 biolink:NamedThing brassinosteroid catabolic process The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. got7fsn_ti brassinosteroid breakdown|brassinosteroid catabolism|brassinosteroid degradation biological_process owl:Class
GO:0071287 biolink:NamedThing cellular response to manganese ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus. got7fsn_ti cellular response to manganese mah 2009-12-10T04:06:18Z biological_process owl:Class
GO:0033776 biolink:NamedThing phenylacetone monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + phenylacetone = benzyl acetate + H(2)O + NADP(+). got7fsn_ti PAMO|phenylacetone,NADPH:oxygen oxidoreductase activity KEGG_REACTION:R07201|MetaCyc:1.14.13.92-RXN|RHEA:10124|EC:1.14.13.92 molecular_function owl:Class
GO:0030640 biolink:NamedThing polyketide catabolic process The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. got7fsn_ti polyketide breakdown|polyketide catabolism|polyketide degradation biological_process owl:Class
GO:0106155 biolink:NamedThing peptidyl-lysine 3-dioxygenase activity Catalysis of the reaction: protein L-lysine + 2-oxoglutarate + O2 = protein 3-hydroxy-L-lysine + succinate + CO2. got7fsn_ti hjd 2018-11-15T20:09:45Z RHEA:57152|EC:1.14.11.63 molecular_function owl:Class
GO:0031480 biolink:NamedThing myosin X complex A myosin complex containing one or more class X myosin heavy chains and associated light chains. got7fsn_ti cellular_component owl:Class
GO:0008805 biolink:NamedThing carbon-monoxide oxygenase activity Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561. got7fsn_ti cytochrome b561|carbon-monoxide dehydrogenase (cytochrome b-561)|carbon monoxide,water:cytochrome b-561 oxidoreductase activity|carbon monoxide oxygenase (cytochrome b-561) activity|carbon monoxide oxidase activity|carbon monoxide:methylene blue oxidoreductase activity|carbon monoxide oxygenase activity GO:0018999|GO:0047767 EC:1.2.5.3|UM-BBD_reactionID:r0650|MetaCyc:RXN-21452|RHEA:48880|Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561) molecular_function owl:Class
GO:0005250 biolink:NamedThing A-type (transient outward) potassium channel activity Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential. got7fsn_ti Reactome:R-HSA-5577234 molecular_function owl:Class
GO:0098690 biolink:NamedThing glycinergic synapse A synapse that uses glycine as a neurotransmitter. got7fsn_ti dos 2017-03-07T14:50:33Z cellular_component owl:Class
GO:0102344 biolink:NamedThing 3-hydroxy-behenoyl-CoA dehydratase activity Catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA <=> trans-2-docosenoyl-CoA + H2O. got7fsn_ti EC:4.2.1.134|MetaCyc:RXN-13303 molecular_function owl:Class
GO:0018907 biolink:NamedThing dimethyl sulfoxide metabolic process The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing. got7fsn_ti dimethyl sulfoxide metabolism|DMSO metabolism|dimethyl sulphoxide metabolism|DMSO metabolic process|dimethyl sulphoxide metabolic process UM-BBD_pathwayID:sulf biological_process owl:Class
GO:0140364 biolink:NamedThing GW body A ribonucleoprotein granule located in the cytoplasm and the nucleus. GW-bodies minimally contain the Argonaute2 (Ago2) and TNRC6B proteins, together with specific target RNAs. got7fsn_ti GW-body pg 2019-07-25T19:26:48Z cellular_component owl:Class
GO:0050917 biolink:NamedThing sensory perception of umami taste The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process. got7fsn_ti umami taste perception biological_process owl:Class
GO:0004416 biolink:NamedThing hydroxyacylglutathione hydrolase activity Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. got7fsn_ti S-2-hydroxylacylglutathione hydrolase activity|acetoacetylglutathione hydrolase activity|S-(2-hydroxyacyl)glutathione hydrolase activity|glyoxalase II activity Reactome:R-HSA-6783221|MetaCyc:GLYOXII-RXN|EC:3.1.2.6|RHEA:25245 molecular_function owl:Class
GO:0033200 biolink:NamedThing inositol heptakisphosphate 5-kinase activity Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate. got7fsn_ti diphosphoinositol-pentakisphosphate 5-kinase activity|IP7 5-kinase activity molecular_function owl:Class
GO:0043139 biolink:NamedThing 5'-3' DNA helicase activity Unwinding a DNA helix in the 5' to 3' direction, driven by ATP hydrolysis. got7fsn_ti DNA helicase IV activity|ATP-dependent 5'-3' DNA helicase activity|5' to 3' DNA helicase activity|ATP-dependent 5' to 3' DNA helicase activity GO:0043141|GO:0008722 Reactome:R-HSA-6782131 molecular_function owl:Class
GO:0047026 biolink:NamedThing androsterone dehydrogenase (A-specific) activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD(P)+. got7fsn_ti 3alpha-hydroxysteroid dehydrogenase (A-specific)|3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific)|3-alpha-hydroxysteroid dehydrogenase (A-specific) activity MetaCyc:1.1.1.213-RXN|Wikipedia:3alpha-hydroxysteroid_dehydrogenase_(A-specific)|EC:1.1.1.213 molecular_function owl:Class
GO:0036269 biolink:NamedThing swimming behavior The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water. got7fsn_ti swimming behaviour bf 2012-07-04T10:14:49Z biological_process owl:Class
GO:0102103 biolink:NamedThing demethoxycurcumin synthase Catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O <=> bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide. got7fsn_ti EC:2.3.1.219|MetaCyc:RXN-11223|RHEA:35119 molecular_function owl:Class
GO:0003851 biolink:NamedThing 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine. got7fsn_ti cerebroside synthase activity|UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity|UDPgalactose:ceramide galactosyltransferase activity|UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity|UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity|UDP-galactose-ceramide galactosyltransferase activity|UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity|uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity EC:2.4.1.47|MetaCyc:2.4.1.45-RXN|RHEA:10856 molecular_function owl:Class
GO:0045843 biolink:NamedThing negative regulation of striated muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development. got7fsn_ti down-regulation of striated muscle development|inhibition of striated muscle development|down regulation of striated muscle development|downregulation of striated muscle development biological_process owl:Class
GO:0033149 biolink:NamedThing FFAT motif binding Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family. got7fsn_ti molecular_function owl:Class
GO:0090634 biolink:NamedThing microglial cell mediated cytotoxicity The directed killing of a target cell by a microglial cell. got7fsn_ti tb 2015-04-14T14:04:54Z biological_process owl:Class
GO:0019797 biolink:NamedThing procollagen-proline 3-dioxygenase activity Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2. got7fsn_ti procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity|procollagen-proline,2-oxoglutarate 3-dioxygenase activity|prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity|proline,2-oxoglutarate 3-dioxygenase activity|prolyl 3-hydroxylase activity|protocollagen proline 3-hydroxylase activity MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN|EC:1.14.11.7|KEGG_REACTION:R03218|RHEA:22872|Reactome:R-HSA-1980233 molecular_function owl:Class
GO:0018229 biolink:NamedThing peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester. got7fsn_ti peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine|peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine|peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine RESID:AA0105 biological_process owl:Class
GO:0044526 biolink:NamedThing formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide. got7fsn_ti jl 2012-03-15T09:45:19Z biological_process owl:Class
GO:0071062 biolink:NamedThing alphav-beta3 integrin-vitronectin complex A protein complex that consists of an alphav-beta3 integrin complex bound to vitronectin. got7fsn_ti ITGAV-ITGB3-VTN complex mah 2009-11-03T04:02:57Z cellular_component owl:Class
GO:0031146 biolink:NamedThing SCF-dependent proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome. got7fsn_ti SCF-dependent proteasomal ubiquitin-dependent protein breakdown|SCF-dependent proteasomal ubiquitin-dependent protein degradation|SCF-dependent proteasomal ubiquitin-dependent protein catabolism biological_process owl:Class
GO:0050548 biolink:NamedThing trans-feruloyl-CoA hydratase activity Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA. got7fsn_ti trans-feruloyl-CoA hydro-lyase activity|4-hydroxy-3-methoxyphenyl-beta-hydroxypropanoyl-CoA hydro-lyase (trans-feruloyl-CoA-forming) RHEA:14517|EC:4.2.1.101|MetaCyc:4.2.1.101-RXN molecular_function owl:Class
GO:0062153 biolink:NamedThing C5-methylcytidine-containing RNA binding Binding to an RNA molecule modified by C5-methylcytidine. got7fsn_ti C5-methylcytosine-containing RNA binding dph 2019-09-18T14:46:22Z molecular_function owl:Class
GO:0004414 biolink:NamedThing homoserine O-acetyltransferase activity Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA. got7fsn_ti homoserine transacetylase activity|homoserine acetyltransferase activity|L-homoserine O-acetyltransferase activity|homoserine O-trans-acetylase activity|acetyl-CoA:L-homoserine O-acetyltransferase activity|homoserine-O-transacetylase activity EC:2.3.1.31|KEGG_REACTION:R01776|MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN|RHEA:13701 molecular_function owl:Class
GO:0018808 biolink:NamedThing trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde. got7fsn_ti UM-BBD_reactionID:r0484 molecular_function owl:Class
GO:0042860 biolink:NamedThing achromobactin metabolic process The chemical reactions and pathways involving achromobactin, a citrate siderophore. got7fsn_ti achromobactin metabolism biological_process owl:Class
GO:0004992 biolink:NamedThing platelet activating factor receptor activity Combining with platelet activating factor to initiate a change in cell activity. got7fsn_ti PAF receptor activity molecular_function owl:Class
GO:0007118 biolink:NamedThing budding cell apical bud growth Growth at the tip of a bud, in a cell that reproduces by budding. got7fsn_ti apical bud growth biological_process owl:Class
GO:2000826 biolink:NamedThing regulation of heart morphogenesis Any process that modulates the frequency, rate or extent of heart morphogenesis. got7fsn_ti regulation of cardiac morphogenesis vk 2011-07-19T10:08:58Z biological_process owl:Class
GO:0004452 biolink:NamedThing isopentenyl-diphosphate delta-isomerase activity Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. got7fsn_ti isopentenylpyrophosphate isomerase activity|isopentenylpyrophosphate delta-isomerase activity|IPP isomerase activity|methylbutenylpyrophosphate isomerase activity|isopentenyl-diphosphate D-isomerase activity|isopentenyl-diphosphate delta3-delta2-isomerase activity KEGG_REACTION:R01123|RHEA:23284|MetaCyc:IPPISOM-RXN|Reactome:R-HSA-191382|EC:5.3.3.2 molecular_function owl:Class
GO:1902086 biolink:NamedThing fumagillin biosynthetic process The chemical reactions and pathways resulting in the formation of fumagillin. got7fsn_ti fumagillin formation|fumagillin synthesis|fumagillin anabolism|fumagillin biosynthesis di 2013-04-25T14:00:50Z biological_process owl:Class
GO:0031384 biolink:NamedThing regulation of initiation of mating projection growth Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi. got7fsn_ti biological_process owl:Class
GO:0050687 biolink:NamedThing negative regulation of defense response to virus Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication. got7fsn_ti negative regulation of antiviral response|downregulation of antiviral response|inhibition of antiviral response|down-regulation of antiviral response|down regulation of antiviral response biological_process owl:Class
GO:0031772 biolink:NamedThing type 2 hypocretin receptor binding Binding to a type 2 hypocretin receptor. got7fsn_ti type 2 orexin receptor binding|type 2 hypocretin receptor ligand molecular_function owl:Class
GO:0031290 biolink:NamedThing retinal ganglion cell axon guidance The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. got7fsn_ti retinal ganglion cell axon pathfinding biological_process owl:Class
GO:0018036 biolink:NamedThing C-terminal peptidyl-asparagine amidation The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0083 biological_process owl:Class
GO:0072342 biolink:NamedThing response to anion stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of anion stress, an increase or decrease in the concentration of negatively charged ions in the environment. got7fsn_ti mah 2010-11-05T02:25:28Z biological_process owl:Class
GO:0051720 biolink:NamedThing DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG. got7fsn_ti molecular_function owl:Class
GO:0102819 biolink:NamedThing bixin aldehyde dehydrogenase activity Catalysis of the reaction: bixin aldehyde + O2 + NAD <=> norbixin + NADH + H+. got7fsn_ti MetaCyc:RXN-8237 molecular_function owl:Class
GO:0036240 biolink:NamedThing septal periplasm The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi. got7fsn_ti cell wall-enclosed septal periplasm bf 2012-05-23T10:18:09Z cellular_component owl:Class
GO:0016319 biolink:NamedThing mushroom body development The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells. got7fsn_ti biological_process owl:Class
GO:0005000 biolink:NamedThing vasopressin receptor activity Combining with vasopressin to initiate a change in cell activity. got7fsn_ti vasopressin activated calcium mobilizing receptor activity GO:0016931 molecular_function owl:Class
GO:0050328 biolink:NamedThing tetrahydroberberine oxidase activity Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2. got7fsn_ti (S)-THB oxidase activity|(S)-tetrahydroberberine:oxygen oxidoreductase activity|THB oxidase activity RHEA:13489|EC:1.3.3.8|MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN molecular_function owl:Class
GO:0062211 biolink:NamedThing root regeneration The the regeneration process by which a damaged or lost root regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to form a new root meristem and subsequently new root. got7fsn_ti dph 2020-02-21T12:47:41Z biological_process owl:Class
GO:0007202 biolink:NamedThing activation of phospholipase C activity The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand. got7fsn_ti phospholipase C activation Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'. biological_process owl:Class
GO:0010863 biolink:NamedThing positive regulation of phospholipase C activity Any process that increases the rate of phospholipase C activity. got7fsn_ti biological_process owl:Class
GO:0007348 biolink:NamedThing regulation of syncytial blastoderm mitotic cell cycle A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle. got7fsn_ti modulation of syncytial blastoderm cell cycle progression|regulation of syncytial blastoderm cell cycle progression|syncytial blastoderm cell cycle regulation|regulation of progression through syncytial blastoderm mitotic cell cycle|syncytial blastoderm cell cycle modulation|syncytial blastoderm cell cycle regulator|regulation of syncytial blastoderm cell cycle biological_process owl:Class
GO:0106297 biolink:NamedThing E-series resolvin biosynthetic process The chemical reactions and pathways resulting in the formation of resolvin family E-series, hydroxy fatty acids derived from icosapentaenoic acid. got7fsn_ti hjd 2020-08-25T13:49:46Z biological_process owl:Class
GO:0019251 biolink:NamedThing anaerobic cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen. got7fsn_ti cobalamin biosynthetic process, anaerobic|anaerobic vitamin B12 biosynthesis|anaerobic cobalamin anabolism|anaerobic cobalamin synthesis|anaerobic cobalamin formation|vitamin B12 biosynthetic process, anaerobic|cobalamin biosynthesis, anaerobic|anaerobic cobalamin biosynthesis|vitamin B12 biosynthesis, anaerobic|anaerobic vitamin B12 biosynthetic process MetaCyc:COBALSYN-PWY biological_process owl:Class
GO:1990297 biolink:NamedThing renal amino acid absorption A renal system process in which amino acids are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. got7fsn_ti hjd 2014-02-25T22:05:57Z biological_process owl:Class
GO:0042436 biolink:NamedThing indole-containing compound catabolic process The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton. got7fsn_ti indole derivative catabolic process|indole derivative catabolism|indole-containing compound breakdown|indole-containing compound catabolism|indole-containing compound degradation biological_process owl:Class
GO:0047446 biolink:NamedThing (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase activity Catalysis of the reaction: (1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone. got7fsn_ti (1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase activity|(1-hydroxycyclohexan-1-yl)acetyl-CoA cyclohexanone-lyase (acetyl-CoA-forming) EC:4.1.3.35|RHEA:23868|MetaCyc:4.1.3.35-RXN|KEGG_REACTION:R02232 molecular_function owl:Class
GO:0090710 biolink:NamedThing phosphomevalonate decarboxylase activity Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate. got7fsn_ti tb 2016-10-21T15:59:34Z molecular_function owl:Class
GO:0102080 biolink:NamedThing phenylacetyl-coenzyme A:glycine N-acyltransferase activity Catalysis of the reaction: phenylacetyl-CoA + glycine <=> H+ + phenylacetylglycine + coenzyme A. got7fsn_ti RHEA:27850|MetaCyc:RXN-10821|EC:2.3.1.192 molecular_function owl:Class
GO:0047232 biolink:NamedThing galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosyceramide + UDP. got7fsn_ti UDP-N-acetyl-D-glucosamine:D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,6-N-acetylglucosaminyltransferase activity|uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase MetaCyc:2.4.1.164-RXN|EC:2.4.1.164 molecular_function owl:Class
GO:0045027 biolink:NamedThing DNA end binding Binding to DNA ends exposed by the creation of double-strand breaks (DSBs). got7fsn_ti molecular_function owl:Class
GO:0044795 biolink:NamedThing trans-Golgi network to recycling endosome transport The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes. got7fsn_ti jl 2013-08-27T16:04:00Z biological_process owl:Class
GO:0002334 biolink:NamedThing transitional two stage B cell differentiation The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21. got7fsn_ti transitional two stage B-lymphocyte differentiation|transitional two stage B-cell differentiation|transitional two stage B cell development|transitional two stage B lymphocyte differentiation|T2 stage B cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:1900563 biolink:NamedThing dehydroaustinol biosynthetic process The chemical reactions and pathways resulting in the formation of dehydroaustinol. got7fsn_ti dehydroaustinol formation|dehydroaustinol biosynthesis|dehydroaustinol synthesis|dehydroaustinol anabolism di 2012-05-15T06:28:03Z biological_process owl:Class
GO:0034808 biolink:NamedThing benzo(a)pyrene 4,5-dioxygenase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r1126 molecular_function owl:Class
GO:0044211 biolink:NamedThing CTP salvage Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis. got7fsn_ti cytidine 5'-triphosphate salvage|CTP biosynthetic process via salvage pathway jl 2009-10-22T03:24:04Z biological_process owl:Class
GO:0039639 biolink:NamedThing suppression by virus of host cell lysis in response to superinfection The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus. got7fsn_ti lysis inhibition|suppression by virus of host cell lysis in response to superinfecting virus bf 2012-08-17T10:42:27Z biological_process owl:Class
GO:0035644 biolink:NamedThing phosphoanandamide dephosphorylation The process of removing one or more phosphate groups from a phosphorylated anandamide. got7fsn_ti bf 2011-01-21T02:14:04Z biological_process owl:Class
GO:0102968 biolink:NamedThing 10-hydroxygeranial oxidoreductase activity Catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+. got7fsn_ti MetaCyc:RXN-9369|RHEA:32611 molecular_function owl:Class
GO:0050822 biolink:NamedThing peptide stabilization Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded. got7fsn_ti peptide stabilisation|peptide stabilization activity biological_process owl:Class
GO:0050511 biolink:NamedThing undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP. got7fsn_ti MurG transferase activity|UDP-N-acetyl-D-glucosamine:N-acetyl-alpha-D-muramyl(oyl-L-Ala- gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol beta-1,4-N-acetylglucosaminlytransferase activity|undecaprenyldiphospho-muramoylpentapeptide b-N-acetylglucosaminyltransferase activity|UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase activity|undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase activity Note that EC classifies 'UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity ; GO:0051991' and 'undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity ; GO:0050511' under the same EC number, EC:2.4.1.227. MetaCyc:RXN-8976|RHEA:23192|EC:2.4.1.227 molecular_function owl:Class
GO:0009015 biolink:NamedThing N-succinylarginine dihydrolase activity Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+). got7fsn_ti 2-N-succinyl-L-arginine iminohydrolase (decarboxylating)|AstB|N2-succinyl-L-arginine iminohydrolase (decarboxylating)|arginine succinylhydrolase activity|SADH|N2-succinylarginine dihydrolase activity|succinylarginine dihydrolase activity|AruB RHEA:19533|EC:3.5.3.23|KEGG_REACTION:R04189|MetaCyc:SUCCARGDIHYDRO-RXN molecular_function owl:Class
GO:0010375 biolink:NamedThing stomatal complex patterning The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells. got7fsn_ti biological_process owl:Class
GO:1900579 biolink:NamedThing (17Z)-protosta-17(20),24-dien-3beta-ol metabolic process The chemical reactions and pathways involving (17Z)-protosta-17(20),24-dien-3beta-ol. got7fsn_ti (17Z)-protosta-17(20),24-dien-3beta-ol metabolism di 2012-05-15T06:47:07Z biological_process owl:Class
GO:0120002 biolink:NamedThing fusiform vesicle A cytoplasmic vesicle which contains two urothelial plaques and can deliver these plaques to the apical plasma membrane of urothelial superficial (umbrella) cells. It can also be formed by endocytosis of apical plasma membrane during contractions of the urinary bladder. got7fsn_ti https://github.com/geneontology/go-ontology/issues/12996 krc 2017-02-23T21:12:27Z cellular_component owl:Class
GO:0047017 biolink:NamedThing prostaglandin-F synthase activity Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate. got7fsn_ti prostaglandin F synthase activity|prostaglandin-D(2) 11-ketoreductase activity|PGF2alpha synthetase activity|prostaglandin 11-ketoreductase activity|prostaglandin-D2 ketoreductase activity|prostaglandin-F synthetase activity|reductase, 15-hydroxy-11-oxoprostaglandin|synthetase, prostaglandin F2alpha|prostaglandin-D(2) 11-reductase activity|PGD(2) 11-ketoreductase activity|PGD2 11-ketoreductase activity|prostaglandin-D(2) ketoreductase activity|PGF synthetase activity|prostaglandin-D2 11-reductase activity|prostaglandin D2-ketoreductase activity|prostaglandin-D2 11-ketoreductase activity|(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase activity|NADPH-dependent prostaglandin D2 11-keto reductase activity|prostaglandin 11-keto reductase activity|prostaglandin F synthetase activity RHEA:10140|EC:1.1.1.188|MetaCyc:1.1.1.188-RXN molecular_function owl:Class
GO:0070706 biolink:NamedThing RNA nucleotide deletion The modification of an RNA molecule by removal of a single nucleotide. got7fsn_ti RNA nucleotide excision mah 2009-06-08T04:50:51Z biological_process owl:Class
GO:0052757 biolink:NamedThing chondroitin hydrolase activity Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-]. got7fsn_ti chondroitin endo-beta-galactosaminidase activity ai 2011-09-28T10:31:53Z molecular_function owl:Class
GO:0031830 biolink:NamedThing type 5A serotonin receptor binding Binding to a type 5A serotonin receptor. got7fsn_ti type 5A serotonin receptor ligand|5-hydroxytryptamine 5A receptor binding molecular_function owl:Class
GO:0009834 biolink:NamedThing plant-type secondary cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana. got7fsn_ti cellulose and pectin-containing secondary cell wall biogenesis|secondary cell wall biosynthetic process|secondary cell wall anabolism|secondary cell wall formation|secondary cell wall synthesis|secondary cell wall biogenesis biological_process owl:Class
GO:0044310 biolink:NamedThing osmiophilic body A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito. got7fsn_ti jl 2010-02-18T03:18:32Z cellular_component owl:Class
GO:1901965 biolink:NamedThing endoplasmic reticulum to chloroplast transport The directed movement of substances from endoplasmic reticulum to chloroplast. got7fsn_ti ER to chloroplast transport tb 2013-02-20T23:48:52Z biological_process owl:Class
GO:0098514 biolink:NamedThing detection of high humidity stimulus involved in sensory perception The series of events in which a high humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of high humidity. got7fsn_ti dos 2013-09-25T14:20:54Z biological_process owl:Class
GO:0008411 biolink:NamedThing 4-hydroxybutyrate CoA-transferase activity Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate. got7fsn_ti molecular_function owl:Class
GO:0080032 biolink:NamedThing methyl jasmonate esterase activity Catalysis of the reaction: a methyl jasmonate + H2O = a jasmonic acid + methanol. got7fsn_ti MEJA esterase activity|methyl JA esterase activity|jasmonic acid methyl ester esterase activity MetaCyc:RXN-10767 molecular_function owl:Class
GO:0047681 biolink:NamedThing aryl-alcohol dehydrogenase (NADP+) activity Catalysis of the reaction: an aromatic alcohol + NADP+ = an aromatic aldehyde + NADPH. got7fsn_ti NADPH-linked benzaldehyde reductase activity|aryl alcohol dehydrogenase (nicotinamide adenine dinucleotide phosphate)|aryl-alcohol:NADP+ oxidoreductase activity MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-NADP+-RXN|RHEA:17761|EC:1.1.1.91 molecular_function owl:Class
GO:0071857 biolink:NamedThing beta-endorphin receptor binding Binding to a beta-endorphin receptor. got7fsn_ti mah 2010-09-10T03:23:01Z molecular_function owl:Class
GO:0047725 biolink:NamedThing inulosucrase activity Catalysis of the reaction: sucrose + 2,1-beta-D-fructosyl(n) = glucose + 2,1-beta-D-fructosyl(n+1). got7fsn_ti sucrose 1-fructosyltransferase activity|sucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity|sucrose 1-fructosyl transferase activity RHEA:15745|MetaCyc:INULOSUCRASE-RXN|EC:2.4.1.9 molecular_function owl:Class
GO:0103087 biolink:NamedThing methylthiopentylmalate dehydrogenase activity Catalysis of the reaction: 3-(5'-methylthio)pentylmalate <=> H+ + 2-oxo-8-methylthiooctanoate + carbon dioxide. got7fsn_ti MetaCyc:RXNQT-4171 molecular_function owl:Class
GO:0140704 biolink:NamedThing 3',2'-cyclic GMP-AMP binding Binding to 3',2' cyclic GMP-AMP (cGAMP) nucleotide, a cyclic purine dinucleotide that consists of AMP and GMP units cyclized via 3',5' and 2',5' linkages. got7fsn_ti 3',2'-cGAMP binding|3',2'-cyclic GAMP binding|3',2' cyclic-GMP-AMP binding https://github.com/geneontology/go-ontology/issues/21980 pg 2021-08-27T05:44:28Z molecular_function owl:Class
GO:0014720 biolink:NamedThing tonic skeletal muscle contraction A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue. got7fsn_ti biological_process owl:Class
GO:0043795 biolink:NamedThing glyceraldehyde oxidoreductase activity Catalysis of the reaction: A + D-glyceraldehyde + H2O = (R)-glycerate + AH2 + H(+). got7fsn_ti EC:1.2.99.8|RHEA:36047 molecular_function owl:Class
GO:0046702 biolink:NamedThing galactoside 6-L-fucosyltransferase activity Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside. got7fsn_ti molecular_function owl:Class
GO:0102009 biolink:NamedThing proline dipeptidase activity Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal <=> L-proline + a standard alpha amino acid. got7fsn_ti MetaCyc:3.4.13.9-RXN|EC:3.4.13.9 molecular_function owl:Class
GO:0002323 biolink:NamedThing natural killer cell activation involved in immune response The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. got7fsn_ti natural killer cell activation during immune response|NK cell activation during immune response biological_process owl:Class
GO:0008475 biolink:NamedThing procollagen-lysine 5-dioxygenase activity Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2. got7fsn_ti lysine,2-oxoglutarate 5-dioxygenase activity|lysine-2-oxoglutarate dioxygenase activity|protocollagen lysine dioxygenase activity|lysyl hydroxylase activity|lysylprotocollagen dioxygenase activity|protocollagen lysine hydroxylase activity|procollagen-lysine,2-oxoglutarate 5-dioxygenase activity|protocollagen lysyl hydroxylase activity|procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)|lysine hydroxylase activity|collagen lysine hydroxylase activity MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN|EC:1.14.11.4|RHEA:16569|Reactome:R-HSA-1981104 molecular_function owl:Class
GO:0047943 biolink:NamedThing glutamate-methylamine ligase activity Catalysis of the reaction: L-glutamate + ATP + methylammonium = N(5)-methyl-L-glutamine + ADP + 2 H(+) + phosphate. got7fsn_ti L-glutamate:methylamine ligase (ADP-forming)|gamma-glutamylmethylamide synthetase activity KEGG_REACTION:R01585|EC:6.3.4.12|MetaCyc:GLUTAMATE--METHYLAMINE-LIGASE-RXN|RHEA:17117 molecular_function owl:Class
GO:0047463 biolink:NamedThing 2-aminohexano-6-lactam racemase activity Catalysis of the reaction: L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam. got7fsn_ti alpha-amino-epsilon-caprolactam racemase activity|2-amino-hexano-6-lactam racemase activity MetaCyc:5.1.1.15-RXN|KEGG_REACTION:R04736|EC:5.1.1.15|RHEA:14813 molecular_function owl:Class
GO:0033940 biolink:NamedThing glucuronoarabinoxylan endo-1,4-beta-xylanase activity Catalysis of the endohydrolysis of (1->4)-beta-D-xylosyl links in some glucuronoarabinoxylans. got7fsn_ti endoarabinoxylanase activity|glucuronoxylan xylanohydrolase activity|glucuronoxylan xylohydrolase activity|feraxanase activity|feraxan endoxylanase activity|glucuronoarabinoxylan 1,4-beta-D-xylanohydrolase activity|glucuronoxylanase activity MetaCyc:3.2.1.136-RXN|EC:3.2.1.136 molecular_function owl:Class
GO:0001968 biolink:NamedThing fibronectin binding Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. got7fsn_ti molecular_function owl:Class
GO:0014874 biolink:NamedThing response to stimulus involved in regulation of muscle adaptation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation. got7fsn_ti response to stimulus involved in regulation of muscle plasticity biological_process owl:Class
GO:0006427 biolink:NamedThing histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA. got7fsn_ti biological_process owl:Class
GO:0008668 biolink:NamedThing (2,3-dihydroxybenzoyl)adenylate synthase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate. got7fsn_ti ATP:2,3-dihydroxybenzoate adenylyltransferase activity|2,3-dihydroxybenzoate-AMP ligase activity EC:2.7.7.58|MetaCyc:DHBAMPLIG-RXN|RHEA:20229|KEGG_REACTION:R01504 molecular_function owl:Class
GO:0047570 biolink:NamedThing 3-oxoadipate enol-lactonase activity Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate. got7fsn_ti 3-ketoadipate enol-lactonase activity|3-oxoadipic enol-lactone hydrolase activity|4-carboxymethylbut-3-en-4-olide enol-lactonohydrolase activity|beta-ketoadipic enol-lactone hydrolase activity|beta-ketoadipate enol-lactone hydrolase activity|carboxymethylbutenolide lactonase activity RHEA:10184|MetaCyc:3-OXOADIPATE-ENOL-LACTONASE-RXN|EC:3.1.1.24 molecular_function owl:Class
GO:1901605 biolink:NamedThing alpha-amino acid metabolic process The chemical reactions and pathways involving an alpha-amino acid. got7fsn_ti alpha-amino acid metabolism tb 2012-11-08T17:39:50Z biological_process owl:Class
GO:0097140 biolink:NamedThing BIM-BCL-xl complex A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators. got7fsn_ti pr 2011-08-02T01:41:30Z cellular_component owl:Class
GO:0047688 biolink:NamedThing aspartate 4-decarboxylase activity Catalysis of the reaction: L-aspartate = L-alanine + CO2. got7fsn_ti aspartate omega-decarboxylase activity|L-aspartate 4-carboxy-lyase (L-alanine-forming)|aspartic beta-decarboxylase activity|L-aspartate beta-decarboxylase activity|L-aspartate 4-carboxy-lyase activity|L-cysteine sulfinate acid desulfinase activity|aminomalonic decarboxylase activity|aspartic omega-decarboxylase activity|cysteine sulfinic desulfinase activity|desulfinase activity|aspartate beta-decarboxylase activity RHEA:12621|MetaCyc:ASPARTATE-4-DECARBOXYLASE-RXN|EC:4.1.1.12 molecular_function owl:Class
GO:0035180 biolink:NamedThing larval wandering behavior The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction. got7fsn_ti larval wandering behaviour biological_process owl:Class
GO:0007074 biolink:NamedThing positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place. got7fsn_ti activation of transcription on exit from mitosis, from RNA polymerase II promoter|activation of transcription on exit from mitosis, from Pol II promoter biological_process owl:Class
GO:0070737 biolink:NamedThing protein-glycine ligase activity, elongating Catalysis of the posttranslational transfer of one or more glycine residues to a glycine residue covalently attached to the gamma-carboxyl group of a glutamate residue on a target protein, resulting in the elongation of a polyglycine side chain. got7fsn_ti protein glycylase activity, elongating mah 2009-06-19T02:00:21Z molecular_function owl:Class
GO:0046656 biolink:NamedThing folic acid biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. got7fsn_ti vitamin B9 biosynthesis|vitamin M biosynthesis|folic acid biosynthesis|vitamin M biosynthetic process|folate biosynthesis|folic acid formation|folate biosynthetic process|folic acid anabolism|folic acid synthesis|vitamin B9 biosynthetic process MetaCyc:FOLSYN-PWY|Wikipedia:Folic_acid biological_process owl:Class
GO:0034795 biolink:NamedThing cyclohexane monooxygenase activity Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O. got7fsn_ti butane monooxygenase activity|cyclohexane hydroxylase activity EC:1.14.15.-|KEGG_REACTION:R06945|MetaCyc:RXN-8697|UM-BBD_reactionID:r1059 molecular_function owl:Class
GO:1900577 biolink:NamedThing gerfelin catabolic process The chemical reactions and pathways resulting in the breakdown of gerfelin. got7fsn_ti gerfelin degradation|gerfelin breakdown|gerfelin catabolism di 2012-05-15T06:42:39Z biological_process owl:Class
GO:0031466 biolink:NamedThing Cul5-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein. got7fsn_ti CDL5 complex|cullin-RING ligase 5|CRL5 complex|SCF5 complex|EC2S complex cellular_component owl:Class
GO:0030124 biolink:NamedThing AP-4 adaptor complex An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo. got7fsn_ti cellular_component owl:Class
GO:0047386 biolink:NamedThing fructose-2,6-bisphosphate 6-phosphatase activity Catalysis of the reaction: beta-D-fructose 2,6-bisphosphate + H(2)O = beta-D-fructofuranose 2-phosphate + phosphate. got7fsn_ti D-fructose-2,6-bisphosphate 6-phosphohydrolase activity|fructose 2,6-bisphosphate-6-phosphohydrolase activity|fructose-2,6-bisphosphate 6-phosphohydrolase activity|beta-D-fructose-2,6-bisphosphate 6-phosphohydrolase activity KEGG_REACTION:R02730|EC:3.1.3.54|MetaCyc:3.1.3.54-RXN|RHEA:13333 molecular_function owl:Class
GO:0098569 biolink:NamedThing internal side of mycolate outer membrane The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. got7fsn_ti cellular_component owl:Class
GO:1900584 biolink:NamedThing o-orsellinic acid biosynthetic process The chemical reactions and pathways resulting in the formation of o-orsellinic acid. got7fsn_ti o-orsellinic acid synthesis|o-orsellinic acid biosynthesis|o-orsellinic acid anabolism|o-orsellinic acid formation di 2012-05-15T06:48:11Z biological_process owl:Class
GO:0032902 biolink:NamedThing nerve growth factor production The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti NGF production|beta-nerve growth factor production biological_process owl:Class
GO:0060098 biolink:NamedThing membrane reorganization involved in phagocytosis, engulfment The assembly and arrangement of the plasma membrane that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. got7fsn_ti membrane reorganisation involved in phagocytosis, engulfment biological_process owl:Class
GO:0003920 biolink:NamedThing GMP reductase activity Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH. got7fsn_ti NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity|guanylate reductase activity|guanosine 5'-monophosphate reductase activity|guanosine 5'-monophosphate oxidoreductase activity|guanosine 5'-phosphate reductase activity|NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)|NADPH:GMP oxidoreductase (deaminating) activity|guanosine monophosphate reductase activity|inosine-5'-phosphate:NADP+ oxidoreductase (aminating) Note that this function was formerly EC:1.6.6.8. Reactome:R-HSA-514604|MetaCyc:GMP-REDUCT-RXN|RHEA:17185|KEGG_REACTION:R01134|EC:1.7.1.7 molecular_function owl:Class
GO:0051217 biolink:NamedThing molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide). got7fsn_ti RESID:AA0375 biological_process owl:Class
GO:0150008 biolink:NamedThing bulk synaptic vesicle endocytosis Endocytosis of large regions of presynaptic membrane after intense stimulation-mediated fusion of multiple synaptic vesicles. Bulk endocytosis is triggered by high loads of membrane addition through exocytosis of synaptic vesicles and elevated concentration of calcium in the presynapse. got7fsn_ti activity-dependent bulk synaptic vesicle endocytosis|ADBE|bulk endocytosis|activity-dependent bulk endocytosis bc 2017-12-01T10:20:18Z biological_process owl:Class
GO:0008704 biolink:NamedThing 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. got7fsn_ti 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase|5-carboxymethyl-2-hydroxymuconic acid isomerase activity|HHDD isomerase activity|hpaG1|5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity|hpaG-1|CHM isomerase activity|5-carboxymethyl-2-hydroxymuconate D-isomerase activity GO:0018843 MetaCyc:5.3.3.10-RXN|UM-BBD_reactionID:r0366|EC:5.3.3.10|RHEA:18813 molecular_function owl:Class
GO:0035189 biolink:NamedThing Rb-E2F complex A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression. got7fsn_ti retinoblastoma-E2F complex cellular_component owl:Class
GO:0005499 biolink:NamedThing vitamin D binding Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). got7fsn_ti ergocalciferol binding|calciferol binding|cholecalciferol binding molecular_function owl:Class
GO:0004306 biolink:NamedThing ethanolamine-phosphate cytidylyltransferase activity Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine. got7fsn_ti CTP:phosphoethanolamine cytidylyltransferase activity|ET|phosphorylethanolamine transferase activity|phosphoethanolamine cytidylyltransferase activity|CTP:ethanolamine-phosphate cytidylyltransferase activity|CTP-phosphoethanolamine cytidylyltransferase activity|ethanolamine phosphate cytidylyltransferase activity Reactome:R-HSA-1483190|EC:2.7.7.14|RHEA:24592|MetaCyc:2.7.7.14-RXN molecular_function owl:Class
GO:0034879 biolink:NamedThing 2,3,6-trihydroxyisonicotinate decarboxylase activity Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2. got7fsn_ti UM-BBD_reactionID:r1340 molecular_function owl:Class
GO:0016216 biolink:NamedThing isopenicillin-N synthase activity Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N. got7fsn_ti N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)|isopenicillin-N synthetase activity|isopenicillin N synthase activity MetaCyc:1.21.3.1-RXN|EC:1.21.3.1|RHEA:22428|KEGG_REACTION:R04872 molecular_function owl:Class
GO:0031724 biolink:NamedThing CXCR5 chemokine receptor binding Binding to a CXCR5 chemokine receptor. got7fsn_ti CXCR5 chemokine receptor ligand|type 1 Burkitt's lymphoma receptor binding molecular_function owl:Class
GO:0034824 biolink:NamedThing citronellyl-CoA dehydrogenase activity Catalysis of the reaction: citronellyl-CoA + NAD+ = cis-geranyl-CoA + NADH + H+. got7fsn_ti UM-BBD_reactionID:r1159 molecular_function owl:Class
GO:0030223 biolink:NamedThing neutrophil differentiation The process in which a myeloid precursor cell acquires the specialized features of a neutrophil. got7fsn_ti neutrophil granulocyte differentiation|neutrophil granulocytopoiesis|neutrophil cell differentiation biological_process owl:Class
GO:0047639 biolink:NamedThing alcohol oxidase activity Catalysis of the reaction: a primary alcohol + O2 = an aldehyde + H2O2. got7fsn_ti AOX activity|ethanol oxidase activity|alcohol:oxygen oxidoreductase activity Note that the enzyme alcohol oxidase also has methanol oxidase activity (GO:0046563). EC:1.1.3.13|MetaCyc:ALCOHOL-OXIDASE-RXN|RHEA:19829 molecular_function owl:Class
GO:0044396 biolink:NamedThing actin cortical patch organization A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis. got7fsn_ti actin cortical patch organisation jl 2011-12-21T03:33:25Z biological_process owl:Class
GO:0052835 biolink:NamedThing inositol-3,4,6-trisphosphate 1-kinase activity Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+). got7fsn_ti 1D-myo-inositol-trisphosphate 1-kinase activity|IP3 1-kinase activity|ins(3,4,6)P(3) 1-kinase activity|Ins(3,4,6)P3 1-kinase activity|inositol-trisphosphate 1-kinase activity|inositol 3,4,6-trisphosphate 1-kinase activity|ATP:1D-myo-inositol-3,4,6-trisphosphate 1-phosphotransferase activity ai 2011-11-29T01:06:01Z EC:2.7.1.-|Reactome:R-HSA-1855169 molecular_function owl:Class
GO:0044365 biolink:NamedThing envenomation resulting in modulation of platelet aggregation in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism. got7fsn_ti envenomation resulting in regulation of platelet aggregation in other organism jl 2011-10-27T02:36:43Z biological_process owl:Class
GO:0140454 biolink:NamedThing protein aggregate center assembly The reversible aggregation of misfolded proteins and chaperones, formed to shield thermosensitive proteins from degradation until conditions allow disaggregation and refolding. got7fsn_ti PAC assembly|protein aggregate center formation|protein aggregate centre assembly https://github.com/geneontology/go-ontology/issues/19172 pg 2020-04-20T15:43:52Z biological_process owl:Class
GO:0051795 biolink:NamedThing positive regulation of timing of catagen Any process that activates or increases the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. got7fsn_ti up-regulation of catagen|upregulation of catagen|stimulation of catagen|positive regulation of catagen|up regulation of catagen|activation of catagen biological_process owl:Class
GO:0047052 biolink:NamedThing (S)-stylopine synthase activity Catalysis of the reaction: (S)-cheilanthifoline + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-stylopine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. got7fsn_ti (S)-cheilanthifoline oxidase (methylenedioxy-bridge-forming) activity|(S)-cheilanthifoline,NADPH:oxygen oxidoreductase (methylenedioxy-bridge-forming) https://github.com/geneontology/go-ontology/issues/21133 KEGG_REACTION:R04690|EC:1.14.19.64|RHEA:13773|MetaCyc:1.1.3.32-RXN molecular_function owl:Class
GO:0102417 biolink:NamedThing apigenin-7-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: apigenin 7-O-beta-D-glucoside + UDP-alpha-D-glucose <=> apigenin-7-O-gentiobioside + UDP + H+. got7fsn_ti MetaCyc:RXN-13800 molecular_function owl:Class
GO:0016401 biolink:NamedThing palmitoyl-CoA oxidase activity Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide. got7fsn_ti EC:1.3.3.- molecular_function owl:Class
GO:0018570 biolink:NamedThing p-cumate 2,3-dioxygenase activity Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate. got7fsn_ti RHEA:42344|UM-BBD_reactionID:r0395|EC:1.14.12.25|MetaCyc:RXN-664 molecular_function owl:Class
GO:0047597 biolink:NamedThing 6-oxocineole dehydrogenase activity Catalysis of the reaction: 6-oxocineole + H(+) + NADPH + O(2) = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H(2)O + NADP(+). got7fsn_ti 6-oxocineole oxygenase activity|6-oxocineole,NADPH:oxygen oxidoreductase activity EC:1.14.13.51|KEGG_REACTION:R02995|MetaCyc:6-OXOCINEOLE-DEHYDROGENASE-RXN|RHEA:24324 molecular_function owl:Class
GO:0042392 biolink:NamedThing sphingosine-1-phosphate phosphatase activity Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. got7fsn_ti sphingosine-1-phosphate phosphohydrolase activity|SPPase activity|SPP phosphatase activity RHEA:27518|MetaCyc:RXN3DJ-25|Reactome:R-HSA-428696|Reactome:R-HSA-428701|Reactome:R-HSA-428690 molecular_function owl:Class
GO:0034029 biolink:NamedThing 2-oxoglutarate carboxylase activity Catalysis of the reaction: 2-oxoglutarate + ATP + bicarbonate = ADP + 2 H(+) + oxalosuccinate + phosphate. got7fsn_ti CFI|oxalosuccinate synthetase activity|OGC|carboxylating factor for ICDH MetaCyc:RXN-8457|RHEA:20425|KEGG_REACTION:R08201|EC:6.4.1.7 molecular_function owl:Class
GO:1900792 biolink:NamedThing shamixanthone catabolic process The chemical reactions and pathways resulting in the breakdown of shamixanthone. got7fsn_ti shamixanthone breakdown|shamixanthone catabolism|shamixanthone degradation di 2012-06-04T09:40:42Z biological_process owl:Class
GO:0047580 biolink:NamedThing 4-hydroxyproline epimerase activity Catalysis of the reaction: trans-4-hydroxy-L-proline = cis-4-hydroxy-D-proline. got7fsn_ti L-hydroxyproline epimerase activity|hydroxyproline epimerase activity|4-hydroxyproline 2-epimerase activity|hydroxyproline 2-epimerase activity KEGG_REACTION:R03296|MetaCyc:4-HYDROXYPROLINE-EPIMERASE-RXN|RHEA:21152|EC:5.1.1.8 molecular_function owl:Class
GO:0051798 biolink:NamedThing positive regulation of hair follicle development Any process that activates or increases the frequency, rate or extent of hair follicle development. got7fsn_ti up-regulation of hair follicle development|up regulation of hair follicle development|activation of hair follicle development|stimulation of hair follicle development|upregulation of hair follicle development biological_process owl:Class
GO:0051743 biolink:NamedThing red chlorophyll catabolite reductase activity Catalysis of the reaction: red chlorophyll catabolite + reduced ferredoxin + 2 H+ = primary fluorescent catabolite + oxidized ferredoxin. This reaction is the reduction of the C20/C1 double bond in the pyrrole system of red chlorophyll catabolite (RCC) to a colorless tetrapyrrole (pFCC) with a strong blue fluorescence. got7fsn_ti RCC reductase activity MetaCyc:RXN-7741|RHEA:24752 molecular_function owl:Class
GO:0042268 biolink:NamedThing regulation of cytolysis Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm. got7fsn_ti biological_process owl:Class
GO:0050441 biolink:NamedThing 3-ethylmalate synthase activity Catalysis of the reaction: butanoyl-CoA + glyoxylate + H(2)O = 3-ethylmalate + CoA + H(+). got7fsn_ti butanoyl-CoA:glyoxylate C-butanoyltransferase (thioester-hydrolysing, 1-carboxypropyl-forming)|3-ethylmalate glyoxylate-lyase (CoA-butanoylating) activity|2-ethyl-3-hydroxybutanedioate synthase activity EC:2.3.3.7|KEGG_REACTION:R01180|MetaCyc:3-ETHYLMALATE-SYNTHASE-RXN|RHEA:10500 molecular_function owl:Class
GO:0008878 biolink:NamedThing glucose-1-phosphate adenylyltransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate. got7fsn_ti ADPG pyrophosphorylase activity|ADP-glucose pyrophosphorylase activity|adenosine diphosphate glucose pyrophosphorylase activity|ATP:alpha-glucose-1-phosphate adenylyl transferase activity|ADGase activity|ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity|ADP glucose pyrophosphorylase activity|ADP-glucose synthetase activity|adenosine diphosphoglucose pyrophosphorylase activity|ADP-glucose synthase activity|ADP-glucose diphosphorylase activity|ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity|glucose 1-phosphate adenylyltransferase activity KEGG_REACTION:R00948|RHEA:12120|EC:2.7.7.27|MetaCyc:GLUC1PADENYLTRANS-RXN molecular_function owl:Class
GO:0007541 biolink:NamedThing sex determination, primary response to X:A ratio The developmental process in which an organism interprets its X to autosomal chromosomal complement. got7fsn_ti biological_process owl:Class
GO:0031009 biolink:NamedThing plastid ADPG pyrophosphorylase complex An ADPG pyrophosphorylase complex found in a plastid. got7fsn_ti cellular_component owl:Class
GO:0046511 biolink:NamedThing sphinganine biosynthetic process The chemical reactions and pathways resulting in the formation of sphinganine, D-erythro-2-amino-1,3-octadecanediol. got7fsn_ti sphinganine anabolism|dihydrosphingosine biosynthetic process|sphinganine synthesis|dihydrosphingosine biosynthesis|sphinganine formation|sphinganine biosynthesis biological_process owl:Class
GO:0033862 biolink:NamedThing UMP kinase activity Catalysis of the reaction: ATP + UMP = ADP + UDP. got7fsn_ti uridine monophosphate kinase activity|SmbA|ATP:UMP phosphotransferase activity|PyrH|UMPK|UMP-kinase activity MetaCyc:2.7.4.22-RXN|EC:2.7.4.22|RHEA:24400 molecular_function owl:Class
GO:0051401 biolink:NamedThing CH domain binding Binding to a calponin homology protein domain, a domain of 100 residues that occurs in signaling and cytoskeletal proteins. got7fsn_ti calponin homology domain binding molecular_function owl:Class
GO:2001043 biolink:NamedThing positive regulation of septum digestion after cytokinesis Any process that activates or increases the frequency, rate or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis. got7fsn_ti positive regulation of cytokinetic cell separation|positive regulation of cell separation after cytokinesis mcc 2011-08-30T05:16:57Z biological_process owl:Class
GO:0021790 biolink:NamedThing chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. got7fsn_ti negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme biological_process owl:Class
GO:0060352 biolink:NamedThing cell adhesion molecule production The appearance of a cell adhesion molecule due to biosynthesis or secretion. got7fsn_ti biological_process owl:Class
GO:0050257 biolink:NamedThing riboflavin phosphotransferase activity Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN. got7fsn_ti D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity|alpha-D-glucose-1-phosphate:riboflavin 5'-phosphotransferase activity|riboflavine phosphotransferase activity|G-1-P phosphotransferase activity RHEA:20409|MetaCyc:RIBOFLAVIN-PHOSPHOTRANSFERASE-RXN|KEGG_REACTION:R00550|EC:2.7.1.42 molecular_function owl:Class
GO:0043252 biolink:NamedThing sodium-independent organic anion transport The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0097499 biolink:NamedThing protein localization to non-motile cilium A process in which a protein is transported to, or maintained in, a location within a non-motile cilium. got7fsn_ti protein localization to nonmotile primary cilium pr 2013-08-13T12:16:26Z biological_process owl:Class
GO:0008894 biolink:NamedThing guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. got7fsn_ti pppGpp 5'-phosphohydrolase activity|guanosine pentaphosphatase activity|guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity|guanosine pentaphosphate phosphatase activity|guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity|guanosine pentaphosphate phosphohydrolase activity|guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity|guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity MetaCyc:PPPGPPHYDRO-RXN|RHEA:13073|EC:3.6.1.40 molecular_function owl:Class
GO:0032795 biolink:NamedThing heterotrimeric G-protein binding Binding to a heterotrimeric G-protein. got7fsn_ti molecular_function owl:Class
GO:1990308 biolink:NamedThing type-I dockerin domain binding Binding to a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain. got7fsn_ti tt 2014-03-07T03:10:37Z molecular_function owl:Class
GO:0019927 biolink:NamedThing peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase. got7fsn_ti RESID:AA0313 biological_process owl:Class
GO:2000954 biolink:NamedThing regulation of cyclodextrin metabolic process Any process that modulates the frequency, rate or extent of cyclodextrin metabolic process. got7fsn_ti regulation of cyclodextrin metabolism tt 2011-08-01T02:22:00Z biological_process owl:Class
GO:1990534 biolink:NamedThing thermospermine oxidase activity Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine. got7fsn_ti tb 2014-11-13T00:41:59Z molecular_function owl:Class
GO:0033188 biolink:NamedThing sphingomyelin synthase activity Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin. got7fsn_ti SM synthase activity|SMS1|ceramide:phosphatidylcholine cholinephosphotransferase activity|SMS2|phosphatidylcholine:ceramide cholinephosphotransferase activity MetaCyc:2.7.8.27-RXN|EC:2.7.8.27|Reactome:R-HSA-429786|Reactome:R-HSA-429798|KEGG_REACTION:R08969|RHEA:18765 molecular_function owl:Class
GO:0048487 biolink:NamedThing beta-tubulin binding Binding to the microtubule constituent protein beta-tubulin. got7fsn_ti beta tubulin binding molecular_function owl:Class
GO:0047779 biolink:NamedThing citrate-CoA ligase activity Catalysis of the reaction: ATP + citrate + CoA = (3S)-citryl-CoA + ADP + H(+) + phosphate. got7fsn_ti citrate thiokinase activity|citrate:CoA ligase (ADP-forming)|citrate:CoA ligase activity|citryl-CoA synthetase activity KEGG_REACTION:R01322|RHEA:21472|MetaCyc:CITRATE--COA-LIGASE-RXN|EC:6.2.1.18 molecular_function owl:Class
GO:0032979 biolink:NamedThing protein insertion into mitochondrial inner membrane from matrix The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix. got7fsn_ti protein insertion into mitochondrial membrane from inner side|insertion of proteins into the mitochondrial membrane from the inner side|protein insertion into mitochondrial inner membrane from matrix side biological_process owl:Class
GO:0034929 biolink:NamedThing 1-hydroxypyrene 7,8-monooxygenase activity Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O. got7fsn_ti UM-BBD_reactionID:r0949 molecular_function owl:Class
GO:0047051 biolink:NamedThing D-lactate dehydrogenase (cytochrome c-553) activity Catalysis of the reaction: (R)-lactate + 2 [Fe(III)cytochrome c553] = 2 [Fe(II)cytochrome c553] + 2 H+ + pyruvate. got7fsn_ti (R)-lactate:ferricytochrome-c-553 2-oxidoreductase activity MetaCyc:1.1.2.5-RXN|RHEA:16465|EC:1.1.2.5 molecular_function owl:Class
GO:0043864 biolink:NamedThing indoleacetamide hydrolase activity Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA. got7fsn_ti indole-3-acetamide hydrolase activity|IAH|IaaH|indole acetamide hydrolase activity|Tms2 MetaCyc:G-5841|EC:3.5.1.4|RHEA:34371 molecular_function owl:Class
GO:0018541 biolink:NamedThing p-benzoquinone reductase (NADPH) activity Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+). got7fsn_ti NADPH:p-benzoquinone oxidoreductase activity KEGG_REACTION:R05244|UM-BBD_enzymeID:e0422|EC:1.6.5.6|RHEA:23488|MetaCyc:1.6.5.6-RXN molecular_function owl:Class
GO:0090217 biolink:NamedThing negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. got7fsn_ti tb 2010-01-12T10:00:45Z biological_process owl:Class
GO:0098595 biolink:NamedThing perivitelline space The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane). got7fsn_ti dos 2014-04-08T16:07:31Z cellular_component owl:Class
GO:0102547 biolink:NamedThing glucosylglycerate hydrolase activity Catalysis of the reaction: H2O + 2-O-(alpha-D-glucopyranosyl)-D-glycerate <=> alpha-D-glucose + D-glycerate. got7fsn_ti MetaCyc:RXN-14901|RHEA:32059 molecular_function owl:Class
GO:0047612 biolink:NamedThing acid-CoA ligase (GDP-forming) activity Catalysis of the reaction: a carboxylate + CoA + GTP = acyl-CoA + GDP + H(+) + phosphate. got7fsn_ti acid:CoA ligase (GDP-forming)|acyl-CoA synthetase (GDP-forming) activity|acyl coenzyme A synthetase (guanosine diphosphate forming) EC:6.2.1.10|MetaCyc:ACID--COA-LIGASE-GDP-FORMING-RXN|RHEA:10968|KEGG_REACTION:R00394 molecular_function owl:Class
GO:0090508 biolink:NamedThing phenylethylamine biosynthetic process involved in synaptic transmission The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission. got7fsn_ti tb 2012-11-15T15:10:23Z biological_process owl:Class
GO:0003693 biolink:NamedThing P-element binding Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis. got7fsn_ti molecular_function owl:Class
GO:0016752 biolink:NamedThing sinapoyltransferase activity Catalysis of the transfer of a sinapoyl group to an acceptor molecule. got7fsn_ti molecular_function owl:Class
GO:0061044 biolink:NamedThing negative regulation of vascular wound healing Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. got7fsn_ti dph 2010-02-25T10:24:28Z biological_process owl:Class
GO:0050219 biolink:NamedThing prostaglandin-A1 delta-isomerase activity Catalysis of the reaction: prostaglandin A1 = prostaglandin C1. got7fsn_ti prostaglandin-A1 D-isomerase activity|(13E)-(15S)-15-hydroxy-9-oxoprosta-10,13-dienoate delta10-delta11-isomerase activity|prostaglandin A isomerase activity MetaCyc:PROSTAGLANDIN-A1-DELTA-ISOMERASE-RXN|RHEA:10460|EC:5.3.3.9|KEGG_REACTION:R04565 molecular_function owl:Class
GO:1990473 biolink:NamedThing ciliary targeting signal binding Binding to a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane. got7fsn_ti CTS binding pr 2014-09-02T08:22:03Z molecular_function owl:Class
GO:0043644 biolink:NamedThing tetracycline biosynthetic process The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). got7fsn_ti tetracyclin biosynthesis|tetracyclin biosynthetic process biological_process owl:Class
GO:0047020 biolink:NamedThing 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-9-alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate. got7fsn_ti dehydrogenase, prostaglandin D2|prostaglandin-D 15-dehydrogenase (NADP(+)) activity|15-hydroxyprostaglandin dehydrogenase (NADP)|15-hydroxy PGD2 dehydrogenase activity|(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP+ 15-oxidoreductase activity|prostaglandin D2 dehydrogenase activity|NADP-PGD2 dehydrogenase activity|prostaglandin-D 15-dehydrogenase (NADP+) activity|prostaglandin-D 15-dehydrogenase (NADP)|dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate)|NADP-linked prostaglandin D2 dehydrogenase activity|NADP-dependent 15-hydroxyprostaglandin dehydrogenase|NADP-linked 15-hydroxyprostaglandin dehydrogenase|NADP-specific 15-hydroxyprostaglandin dehydrogenase RHEA:20744|EC:1.1.1.196|MetaCyc:1.1.1.196-RXN molecular_function owl:Class
GO:0000970 biolink:NamedThing tRNA exon ligation utilizing GTP as source of linkage phosphate A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process. got7fsn_ti krc 2009-04-28T10:33:25Z biological_process owl:Class
GO:0072521 biolink:NamedThing purine-containing compound metabolic process The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof. got7fsn_ti purine and derivative metabolic process|purine-containing compound metabolism mah 2011-01-04T03:03:59Z biological_process owl:Class
GO:0009073 biolink:NamedThing aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). got7fsn_ti aromatic amino acid family formation|aromatic amino acid family biosynthetic process, shikimate pathway|aromatic amino acid family biosynthesis|aromatic amino acid family anabolism|aromatic amino acid family synthesis GO:0016089 MetaCyc:COMPLETE-ARO-PWY biological_process owl:Class
GO:1990920 biolink:NamedThing proteasome localization to nuclear periphery Any process in which the proteasome is transported to, or maintained at the nuclear periphery. got7fsn_ti vw 2015-12-14T17:14:00Z biological_process owl:Class
GO:0031144 biolink:NamedThing proteasome localization Any process in which the proteasome is transported to, or maintained in, a specific location. got7fsn_ti establishment and maintenance of proteasome localization|proteasome localisation biological_process owl:Class
GO:0010044 biolink:NamedThing response to aluminum ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus. got7fsn_ti response to aluminium ion|response to aluminum biological_process owl:Class
GO:0042333 biolink:NamedThing chemotaxis to oxidizable substrate The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose. got7fsn_ti taxis in response to oxidizable substrate biological_process owl:Class
GO:1990603 biolink:NamedThing dark adaptation The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light. got7fsn_ti The proteins RGS9-1 and Gb5L localize to the rod inner segment during dark adaptation, but to the rod outer segment during light adaptation. PMID:23555598 hjd 2015-01-09T20:35:46Z biological_process owl:Class
GO:0072754 biolink:NamedThing cellular response to purvalanol A Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus. got7fsn_ti mah 2012-11-07T12:05:57Z biological_process owl:Class
GO:0047357 biolink:NamedThing UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase activity Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + UDP-D-galactose = H(+) + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine + UMP. got7fsn_ti uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase activity|galactose-1-phosphotransferase activity|UDPgalactose-UDP-N-acetylglucosamine galactose phosphotransferase activity|galactosyl phosphotransferase activity|UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity|UDPgalactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase activity MetaCyc:2.7.8.18-RXN|RHEA:22440|EC:2.7.8.18|KEGG_REACTION:R00504 molecular_function owl:Class
GO:0019085 biolink:NamedThing early viral transcription The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell. got7fsn_ti immediate early viral mRNA transcription biological_process owl:Class
GO:0102699 biolink:NamedThing 2-methylpropionitrile hydroxylase activity Catalysis of the reaction: H+ + 2-methylpropionitrile + O2 + NADPH <=> 2-hydroxy-2-methylpropanenitrile + NADP + H2O. got7fsn_ti MetaCyc:RXN-5082|RHEA:51964 molecular_function owl:Class
GO:0102527 biolink:NamedThing 8-demethylnovobiocate synthase activity Catalysis of the reaction: 3-amino-4,7-dihydroxycoumarin + 3-dimethylallyl-4-hydroxybenzoate + ATP(4-) <=> H+ + 8-desmethylnovobiocic acid(1-) + AMP(2-) + diphosphoric acid. got7fsn_ti RHEA:36699|MetaCyc:RXN-14547|EC:6.3.1.15 molecular_function owl:Class
GO:0021811 biolink:NamedThing growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex. got7fsn_ti growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration|growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:0034480 biolink:NamedThing phosphatidylcholine phospholipase C activity Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate. got7fsn_ti lipophosphodiesterase I activity|heat-labile hemolysin|phospholipase C, acting on phosphatidylcholine|Clostridium welchii alpha-toxin activity|Clostridium oedematiens beta- and gamma-toxins activity|alpha-toxin|phosphatidylcholine cholinephosphohydrolase activity EC:3.1.4.3|MetaCyc:PHOSPHOLIPASE-C-RXN|RHEA:10604 molecular_function owl:Class
GO:0047559 biolink:NamedThing 3-dehydro-L-gulonate 2-dehydrogenase activity Catalysis of the reaction: 3-dehydro-L-gulonate + NAD(P)+ = (4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H + H+. got7fsn_ti 3-keto-L-gulonate dehydrogenase activity|3-ketogulonate dehydrogenase activity|3-dehydro-L-gulonate:NAD(P)+ 2-oxidoreductase activity|2,3-diketo-L-gulonate reductase activity EC:1.1.1.130|MetaCyc:3-DEHYDRO-L-GULONATE-2-DEHYDROGENASE-RXN molecular_function owl:Class
GO:0070284 biolink:NamedThing 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity Catalysis of the reaction: 5-aminoimidazole ribonucleotide + S-adenosylmethionine = 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate + 5'deoxyadenosine. got7fsn_ti HMP-P synthase activity|ThiC molecular_function owl:Class
GO:0036030 biolink:NamedThing protein C inhibitor-plasma kallikrein complex A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein. got7fsn_ti PCI-plasma kallikrein complex|protein C inhibitor-KLKB1 complex|serpin A5-plasma kallikrein complex|plasma serine protease inhibitor-plasma kallikrein complex|SERPINA5-plasma kallikrein complex bf 2011-10-19T02:05:46Z cellular_component owl:Class
GO:0061593 biolink:NamedThing sulfoquinovose isomerase activity Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose. got7fsn_ti dph 2014-02-10T09:56:04Z molecular_function owl:Class
GO:0003832 biolink:NamedThing beta-alanyl-dopamine hydrolase activity Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine. got7fsn_ti NBAD hydrolase activity|N-beta-alanyl-dopamine hydrolase activity molecular_function owl:Class
GO:0001821 biolink:NamedThing histamine secretion The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems. got7fsn_ti biological_process owl:Class
GO:0003133 biolink:NamedThing endodermal-mesodermal cell signaling Any process that mediates the transfer of information from endodermal cells to mesodermal cells. got7fsn_ti endodermal-mesodermal cell signalling tb 2009-09-22T03:10:29Z biological_process owl:Class
GO:0010394 biolink:NamedThing homogalacturonan metabolic process The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3. got7fsn_ti homogalacturonan metabolism biological_process owl:Class
GO:0034211 biolink:NamedThing GTP-dependent protein kinase activity GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. got7fsn_ti The reaction requires the presence of GTP. molecular_function owl:Class
GO:0050272 biolink:NamedThing S-carboxymethylcysteine synthase activity Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H(+). got7fsn_ti 3-chloro-L-alanine chloride-lyase (adding thioglycolate)|S-carboxymethyl-L-cysteine synthase activity|3-chloro-L-alanine chloride-lyase (adding thioglycolate; S-carboxymethyl-L-cysteine-forming) EC:4.5.1.5|KEGG_REACTION:R04003|RHEA:22868|MetaCyc:S-CARBOXYMETHYLCYSTEINE-SYNTHASE-RXN molecular_function owl:Class
GO:0047862 biolink:NamedThing diisopropyl-fluorophosphatase activity Catalysis of the reaction: diisopropyl fluorophosphate + H(2)O = diisopropyl phosphate + 2 H(+) + hydrogen fluoride. got7fsn_ti diisopropyl-fluorophosphate fluorohydrolase activity|isopropylphosphorofluoridase activity|OPAA activity|tabunase activity|diisopropylfluorophosphonate dehalogenase activity|organophosphate acid anhydrase activity|diisopropyl phosphorofluoridate hydrolase activity|dialkylfluorophosphatase activity|diisopropylphosphofluoridase activity|DFPase activity|organophosphorus acid anhydrolase activity|OPA anhydrase activity|somanase activity RHEA:24100|KEGG_REACTION:R01533|MetaCyc:DIISOPROPYL-FLUOROPHOSPHATASE-RXN|EC:3.1.8.2 molecular_function owl:Class
GO:0052767 biolink:NamedThing mannosyl-oligosaccharide 1,6-alpha-mannosidase activity Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide. got7fsn_ti alpha-1,6-mannosidase activity|1,6-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity|alpha-1,6-mannosyl-oligosaccharide alpha-D-mannohydrolase activity|1,6-alpha-mannosidase activity ai 2011-09-30T12:55:24Z EC:3.1.1.- molecular_function owl:Class
GO:0051698 biolink:NamedThing saccharopine oxidase activity Catalysis of the reaction: L-saccharopine + O2 = L-2-aminoadipic 6-semialdehyde + L-glutamate + H2O2. got7fsn_ti SAX activity molecular_function owl:Class
GO:0102632 biolink:NamedThing (S)-nandinine synthase activity Catalysis of the reaction: (S)-scoulerine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-nandinine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21133 RHEA:50364|MetaCyc:RXN-15538|EC:1.14.19.73 molecular_function owl:Class
GO:1904019 biolink:NamedThing epithelial cell apoptotic process Any apoptotic process in an epithelial cell. got7fsn_ti epitheliocyte apoptotic process|epitheliocyte apoptosis|epithelial cell apoptosis sl 2015-03-06T22:27:17Z biological_process owl:Class
GO:1990606 biolink:NamedThing membrane scission GTPase motor activity Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis. got7fsn_ti vw 2015-01-19T14:26:50Z molecular_function owl:Class
GO:0102006 biolink:NamedThing 4-methyl-2-oxopentanoate dehydrogenase activity Catalysis of the reaction: 4-methyl-2-oxopentanoate + coenzyme A(4-) + NAD(1-) <=> isovaleryl-CoA(4-) + carbon dioxide + NADH(2-). got7fsn_ti MetaCyc:2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN|RHEA:25177 molecular_function owl:Class
GO:0102031 biolink:NamedThing 4-acetamido-4,6-dideoxy-D-galactose transferase activity Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol <=> H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP. got7fsn_ti EC:2.4.1.325|RHEA:28759|MetaCyc:FUC4NACTRANS-RXN molecular_function owl:Class
GO:0002567 biolink:NamedThing somatic diversification of FREP-based immune receptors The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails. got7fsn_ti Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species. biological_process owl:Class
GO:0085016 biolink:NamedThing dormancy exit of symbiont in host Exit from dormant state, also known as resuscitation, of the symbiont within the host organism. got7fsn_ti resuscitation of symbiont jl 2010-05-19T03:23:07Z biological_process owl:Class
GO:0044519 biolink:NamedThing envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism. got7fsn_ti envenomation resulting in modulation of VIP receptor activity in other organism|envenomation resulting in regulation of vasoactive intestinal polypeptide receptor activity in other organism|envenomation resulting in regulation of VIP receptor activity in other organism jl 2012-02-26T11:53:33Z biological_process owl:Class
GO:0034575 biolink:NamedThing 4-isopropylaniline dehydrogenase activity Catalysis of the reaction: 4-isopropylaniline + H2O = 4'-(2-hydroxyisopropyl)phenylaniline + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0901|EC:1.17.99.- molecular_function owl:Class
GO:0051919 biolink:NamedThing positive regulation of fibrinolysis Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots. got7fsn_ti upregulation of fibrinolysis|stimulation of fibrinolysis|up regulation of fibrinolysis|activation of fibrinolysis|up-regulation of fibrinolysis biological_process owl:Class
GO:0000424 biolink:NamedThing micromitophagy Degradation of a mitochondrion by lysosomal microautophagy. got7fsn_ti Note that this term is not a child of mitophagy because the community genrally uses that latter to refer to the macroautophagy of mitochondria. biological_process owl:Class
GO:0035507 biolink:NamedThing regulation of myosin-light-chain-phosphatase activity Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity. got7fsn_ti bf 2010-04-30T10:53:38Z biological_process owl:Class
GO:0050614 biolink:NamedThing delta24-sterol reductase activity Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol. got7fsn_ti lanosterol delta24-reductase activity|lanosterol Delta(24)-reductase activity|D24-sterol reductase activity|sterol:NADP+ delta24-oxidoreductase activity MetaCyc:1.3.1.72-RXN|EC:1.3.1.72|Reactome:R-HSA-6807064|RHEA:13685|Reactome:R-HSA-196417 molecular_function owl:Class
GO:0072100 biolink:NamedThing specification of ureteric bud anterior/posterior symmetry The establishment of the ureteric bud such that there is a similar arrangement in form and relationship of parts along its anterior/posterior axis. got7fsn_ti specification of ureteric bud anterior/posterior asymmetry mah 2010-02-10T02:18:16Z biological_process owl:Class
GO:1990010 biolink:NamedThing compound eye retinal cell apoptotic process Any apoptotic process in a compound eye retinal cell. got7fsn_ti pr 2012-12-12T10:21:07Z biological_process owl:Class
GO:0004100 biolink:NamedThing chitin synthase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1). got7fsn_ti UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity|chitin synthetase activity|chitin-uridine diphosphate acetylglucosaminyltransferase activity|chitin-UDP acetyl-glucosaminyl transferase activity|chitin-UDP N-acetylglucosaminyltransferase activity|trans-N-acetylglucosaminosylase activity EC:2.4.1.16|RHEA:16637|MetaCyc:CHITIN-SYNTHASE-RXN molecular_function owl:Class
GO:0070410 biolink:NamedThing co-SMAD binding Binding to a common mediator SMAD signaling protein. got7fsn_ti common-partner SMAD binding|common partner SMAD binding|common mediator SMAD binding|common-mediator SMAD binding molecular_function owl:Class
GO:0046056 biolink:NamedThing dADP metabolic process The chemical reactions and pathways involving dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate). got7fsn_ti dADP metabolism biological_process owl:Class
GO:0071293 biolink:NamedThing cellular response to tellurium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tellurium ion stimulus. got7fsn_ti cellular response to tellurium mah 2009-12-10T04:16:52Z biological_process owl:Class
GO:0047397 biolink:NamedThing dolichylphosphate-glucose phosphodiesterase activity Catalysis of the reaction: dolichyl beta-D-glucosyl phosphate + H2O = dolichol-phosphate + beta-D-glucose. got7fsn_ti dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase activity|dolichyl-phosphate-glucose phosphodiesterase activity|Dol-P-Glc phosphodiesterase activity|dolichol phosphoglucose phosphodiesterase activity EC:3.1.4.48|MetaCyc:3.1.4.48-RXN|RHEA:13857 molecular_function owl:Class
GO:0102174 biolink:NamedThing 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity Catalysis of the reaction: 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NADH + O2 <=> 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol + NAD + H2O. got7fsn_ti MetaCyc:RXN-11927|RHEA:58864 molecular_function owl:Class
GO:0033402 biolink:NamedThing UUC codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a UUC codon. got7fsn_ti phenylalanine tRNA|TTC codon-amino acid adaptor activity Note that in the standard genetic code, TTC codes for phenylalanine. molecular_function owl:Class
GO:0018571 biolink:NamedThing 2,3-dihydroxy-p-cumate dioxygenase activity Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate. got7fsn_ti 2,3-dihydroxy-p-cumate 3,4-dioxygenase|2,3-dihydroxy-p-cumate-3,4-dioxygenase MetaCyc:RXN-666|UM-BBD_reactionID:r0397|RHEA:42568 molecular_function owl:Class
GO:0070575 biolink:NamedThing peptide mating pheromone maturation involved in regulation of pheromone-induced unidirectional conjugation The formation of a mature peptide mating pheromone by proteolysis and/or modification of a peptide precursor, occurring in the context of pheromone-induced unidirectional conjugation. got7fsn_ti peptide mating pheromone formation involved in pheromone-induced unidirectional conjugation|peptide mating pheromone processing involved in pheromone-induced unidirectional conjugation mah 2009-04-20T04:32:07Z biological_process owl:Class
GO:0102320 biolink:NamedThing 1,8-cineole 2-exo-monooxygenase activity Catalysis of the reaction: 1,8-cineole + NADPH + H+ + O2 <=> 2-exo-hydroxy-1,8-cineole + NADP + H2O. got7fsn_ti RHEA:32895|EC:1.14.14.56|MetaCyc:RXN-13133 molecular_function owl:Class
GO:0043778 biolink:NamedThing cobalt-precorrin-8 methylmutase activity Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate. got7fsn_ti cobalt-precorrin 8 methylmutase activity|cobalt-precorrin 8X methylmutase activity|cobalt-precorrin-8X methylmutase activity EC:5.4.99.60|MetaCyc:RXN-8768|RHEA:16209 molecular_function owl:Class
GO:0103008 biolink:NamedThing 4-chloro-2-methylphenoxyacetate oxygenase activity Catalysis of the reaction: 4-chloro-2-methylphenoxyacetate + 2-oxoglutarate + O2 <=> 4-chloro-2-methylphenol + 2-oxo monocarboxylic acid anion + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-9864 molecular_function owl:Class
GO:0047932 biolink:NamedThing glucosamine N-acetyltransferase activity Catalysis of the reaction: D-glucosamine + acetyl-CoA = N-acetyl-D-glucosamine + CoA + H(+). got7fsn_ti glucosamine acetylase activity|acetyl-CoA:D-glucosamine N-acetyltransferase activity|glucosamine acetyltransferase activity RHEA:21332|EC:2.3.1.3|MetaCyc:GLUCOSAMINE-N-ACETYLTRANSFERASE-RXN|KEGG_REACTION:R01204 molecular_function owl:Class
GO:0033950 biolink:NamedThing xyloglucan-specific exo-beta-1,4-glucanase activity Catalysis of the reaction: xyloglucan + H2O = xyloglucan oligosaccharides. This reaction is the exohydrolysis of 1,4-beta-D-glucosidic linkages in xyloglucan. got7fsn_ti [(1->6)-alpha-D-xylo]-(1->4)-beta-D-glucan exo-glucohydrolase activity|Cel74A MetaCyc:3.2.1.155-RXN|EC:3.2.1.155 molecular_function owl:Class
GO:0061755 biolink:NamedThing positive regulation of circulating fibrinogen levels Any process that increases the quantity of fibrinogen circulating in the bloodstream. got7fsn_ti dph 2016-02-29T16:26:49Z biological_process owl:Class
GO:0102075 biolink:NamedThing OPC4-trans-2-enoyl-CoA hydratase activity Catalysis of the reaction: OPC4-3-hydroxyacyl-CoA <=> OPC4-trans-2-enoyl-CoA + H2O. got7fsn_ti MetaCyc:RXN-10705 molecular_function owl:Class
GO:0042751 biolink:NamedThing estivation Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season. got7fsn_ti aestivation Wikipedia:Estivation biological_process owl:Class
GO:1900054 biolink:NamedThing positive regulation of retinoic acid biosynthetic process Any process that activates or increases the frequency, rate or extent of retinoic acid biosynthetic process. got7fsn_ti upregulation of retinoic acid biosynthetic process|up regulation of retinoic acid biosynthetic process|activation of retinoic acid biosynthetic process|positive regulation of retinoic acid anabolic process|up-regulation of retinoic acid biosynthetic process|up regulation of retinoic acid anabolic process|up-regulation of retinoic acid anabolic process|upregulation of retinoic acid anabolic process|activation of retinoic acid anabolic process yaf 2012-01-20T09:55:52Z biological_process owl:Class
GO:0046136 biolink:NamedThing positive regulation of vitamin metabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. got7fsn_ti stimulation of vitamin metabolic process|activation of vitamin metabolic process|up regulation of vitamin metabolic process|up-regulation of vitamin metabolic process|positive regulation of vitamin metabolism|upregulation of vitamin metabolic process biological_process owl:Class
GO:0000296 biolink:NamedThing spermine transport The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0097576 biolink:NamedThing vacuole fusion Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole. got7fsn_ti pr 2014-02-28T09:49:31Z biological_process owl:Class
GO:0102898 biolink:NamedThing levopimaradienol hydroxylase activity Catalysis of the reaction: H+ + levopimaradienol + NADPH + O2 <=> levopiramadiene-diol + NADP + H2O. got7fsn_ti MetaCyc:RXN-8517 molecular_function owl:Class
GO:0102329 biolink:NamedThing hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity Catalysis of the reaction: 16-hydroxy-hentriaconta-3,6,9,12,19,22,25,28-octaene-15-oyl-CoA + NADP <=> hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA + NADPH + H+. got7fsn_ti MetaCyc:RXN-13251 molecular_function owl:Class
GO:0102661 biolink:NamedThing homogentisate solanyltransferase activity Catalysis of the reaction: all-trans-nonaprenyl diphosphate + homogentisate + H+ <=> 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + carbon dioxide + diphosphoric acid. got7fsn_ti RHEA:37995|EC:2.5.1.117|MetaCyc:RXN-2761 molecular_function owl:Class
GO:0050307 biolink:NamedThing sucrose-phosphate phosphatase activity Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. got7fsn_ti sucrose-phosphate phosphohydrolase activity|sucrose-6F-phosphate phosphohydrolase activity KEGG_REACTION:R00805|MetaCyc:SUCROSE-PHOSPHATASE-RXN|KEGG_REACTION:R06211|EC:3.1.3.24|RHEA:19289 molecular_function owl:Class
GO:0044574 biolink:NamedThing starch utilization system complex assembly The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan. got7fsn_ti assembly of starch utilization system complex|SUS complex assembly jl 2012-04-19T03:40:24Z biological_process owl:Class
GO:0042211 biolink:NamedThing dimethylsilanediol catabolic process The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products. got7fsn_ti dimethylsilanediol breakdown|dimethylsilanediol degradation|dimethylsilanediol catabolism|degradation of dimethylsilanediol|catabolic process of DMSD|catabolism of DMSD biological_process owl:Class
GO:0046254 biolink:NamedThing anaerobic toluene catabolic process The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, in the absence of oxygen. got7fsn_ti anaerobic toluene breakdown|anaerobic toluene catabolism|anaerobic toluene degradation MetaCyc:PWY-81 biological_process owl:Class
GO:0050008 biolink:NamedThing isopiperitenone delta-isomerase activity Catalysis of the reaction: isopiperitenone = piperitenone. got7fsn_ti isopiperitenone delta8-delta4-isomerase activity|isopiperitenone D-isomerase activity MetaCyc:ISOPIPERITENONE-DELTA-ISOMERASE-RXN|EC:5.3.3.11|RHEA:21516|KEGG_REACTION:R03782 molecular_function owl:Class
GO:0001048 biolink:NamedThing RNA polymerase IV core binding Binding to RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production. got7fsn_ti krc 2010-09-23T01:41:03Z molecular_function owl:Class
GO:0008909 biolink:NamedThing isochorismate synthase activity Catalysis of the reaction: chorismate = isochorismate. got7fsn_ti isochorismate synthetase activity|isochorismate hydroxymutase activity|isochorismate mutase activity Note that this function was formerly EC:5.4.99.6. RHEA:18985|MetaCyc:ISOCHORSYN-RXN|EC:5.4.4.2|KEGG_REACTION:R01717 molecular_function owl:Class
GO:0050568 biolink:NamedThing protein-glutamine glutaminase activity Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3. got7fsn_ti destabilase activity|peptidoglutaminase II activity|glutaminyl-peptide glutaminase activity|glutaminylpeptide glutaminase activity|protein-L-glutamine amidohydrolase activity|peptidylglutaminase II RHEA:16441|EC:3.5.1.44|MetaCyc:CHEBDEAMID-RXN molecular_function owl:Class
GO:0036210 biolink:NamedThing protein modification process in other organism The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). got7fsn_ti protein modification in other organism bf 2012-04-26T01:29:29Z biological_process owl:Class
GO:0061213 biolink:NamedThing positive regulation of mesonephros development Any process that increases the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti dph 2010-08-17T03:39:35Z biological_process owl:Class
GO:0072689 biolink:NamedThing MCM complex assembly The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication. got7fsn_ti mah 2011-08-12T10:57:29Z biological_process owl:Class
GO:1900840 biolink:NamedThing regulation of helvolic acid biosynthetic process Any process that modulates the frequency, rate or extent of helvolic acid biosynthetic process. got7fsn_ti di 2012-06-07T09:38:33Z biological_process owl:Class
GO:0018113 biolink:NamedThing lysine racemase activity Catalysis of the reaction: L-lysine = D-lysine. got7fsn_ti EC:5.1.1.5|MetaCyc:LYSINE-RACEMASE-RXN|RHEA:22864 molecular_function owl:Class
GO:0017018 biolink:NamedThing myosin phosphatase activity Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. got7fsn_ti myosin phosphatase, intrinsic catalyst activity|myosin phosphatase myosin binding GO:0017019 Reactome:R-HSA-390593|Reactome:R-HSA-445699 molecular_function owl:Class
GO:0047118 biolink:NamedThing 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase activity Catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH. got7fsn_ti 2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity|2,6-dioxo-6-phenylhexanoate:NADP+ delta2-oxidoreductase activity KEGG_REACTION:R03463|RHEA:24268|MetaCyc:1.3.1.40-RXN|EC:1.3.1.40 molecular_function owl:Class
GO:0033510 biolink:NamedThing luteolin metabolic process The chemical reactions and pathways involving luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one. got7fsn_ti luteolin metabolism biological_process owl:Class
GO:0018662 biolink:NamedThing phenol 2-monooxygenase activity Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O. got7fsn_ti phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)|phenol hydroxylase activity|phenol o-hydroxylase activity EC:1.14.13.7|UM-BBD_enzymeID:e0208|MetaCyc:PHENOL-2-MONOOXYGENASE-RXN|RHEA:17061 molecular_function owl:Class
GO:0047104 biolink:NamedThing hexadecanal dehydrogenase (acylating) activity Catalysis of the reaction: CoA + NAD(+) + palmitaldehyde = H(+) + NADH + palmitoyl-CoA. got7fsn_ti hexadecanal:NAD+ oxidoreductase (CoA-acylating)|fatty acyl-CoA reductase activity RHEA:19705|KEGG_REACTION:R01277|EC:1.2.1.42|MetaCyc:1.2.1.42-RXN|UM-BBD_reactionID:r1374 molecular_function owl:Class
GO:0051060 biolink:NamedThing pullulanase activity Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen. got7fsn_ti limit dextrinase|debranching enzyme activity|bacterial debranching enzyme|pullulan alpha-1,6-glucanohydrolase activity|R-enzyme|alpha-dextrin endo-1,6-alpha-glucosidase activity|amylopectin 6-glucanohydrolase activity|pullulan 6-glucanohydrolase activity EC:3.2.1.41|MetaCyc:RXN-1824 molecular_function owl:Class
GO:0035375 biolink:NamedThing zymogen binding Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis. got7fsn_ti proenzyme binding bf 2010-03-18T10:50:35Z molecular_function owl:Class
GO:0035612 biolink:NamedThing AP-2 adaptor complex binding Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). got7fsn_ti AP-2 clathrin adaptor complex binding bf 2010-11-25T03:51:17Z molecular_function owl:Class
GO:0071939 biolink:NamedThing vitamin A import The directed movement of vitamin A into a cell or organelle. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid. got7fsn_ti vitamin A uptake mah 2010-09-30T04:36:22Z biological_process owl:Class
GO:0102191 biolink:NamedThing 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity Catalysis of the reaction: 4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol + NAD(1-) <=> 5alpha-cholesta-7,24-dien-3-one + NADH(2-) + carbon dioxide. got7fsn_ti EC:1.1.1.418|RHEA:59016|MetaCyc:RXN-11959 molecular_function owl:Class
GO:0047371 biolink:NamedThing butyrate-acetoacetate CoA-transferase activity Catalysis of the reaction: acetoacetate + butanoyl-CoA = acetoacetyl-CoA + butanoate. got7fsn_ti butyryl-CoA-acetoacetate CoA-transferase activity|butanoyl-CoA:acetoacetate CoA-transferase activity|butyryl coenzyme A-acetoacetate coenzyme A-transferase activity RHEA:12961|KEGG_REACTION:R01365|EC:2.8.3.9|MetaCyc:2.8.3.9-RXN molecular_function owl:Class
GO:0048381 biolink:NamedThing lateral mesoderm structural organization The process that contributes to the act of creating the structural organization of the lateral mesoderm. This process pertains to the physical shaping of a rudimentary structure. got7fsn_ti lateral mesoderm structural organisation|lateral plate mesoderm structural organization biological_process owl:Class
GO:0047773 biolink:NamedThing carnitinamidase activity Catalysis of the reaction: (R)-carnitinamide + H(2)O = (R)-carnitine + NH(4)(+). got7fsn_ti L-carnitine amidase activity|carnitine amidase activity|L-carnitinamide amidohydrolase activity|L-carnitinamidase activity MetaCyc:CARNITINAMIDASE-RXN|RHEA:17537|EC:3.5.1.73|KEGG_REACTION:R01922 molecular_function owl:Class
GO:0047068 biolink:NamedThing N5,N10-methenyltetrahydromethanopterin hydrogenase activity Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+). got7fsn_ti H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity|H2-dependent methylene-H4MPT dehydrogenase activity|hydrogen:5,10-methenyltetrahydromethanopterin oxidoreductase activity|5,10-methenyltetrahydromethanopterin hydrogenase activity|hydrogen:N5,N10-methenyltetrahydromethanopterin oxidoreductase activity|hydrogen:N(5),N(10)-methenyltetrahydromethanopterin oxidoreductase activity|H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase activity|nonmetal hydrogenase activity|H(2)-dependent methylene-H(4)MPT dehydrogenase activity|N5,N10-methylenetetrahydromethanopterin dehydrogenase activity|N(5),N(10)-methenyltetrahydromethanopterin hydrogenase activity GO:0016947 EC:1.12.98.2|RHEA:20017|KEGG_REACTION:R04455|MetaCyc:H2-METHYLENE-THMPT-DEHYDRO-RXN molecular_function owl:Class
GO:0010355 biolink:NamedThing homogentisate farnesyltransferase activity Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol. got7fsn_ti molecular_function owl:Class
GO:0019159 biolink:NamedThing nicotinamide-nucleotide amidase activity Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3. got7fsn_ti NMN amidohydrolase|nicotinamide-D-ribonucleotide amidohydrolase activity|nicotinamide mononucleotide amidohydrolase activity|NMN deamidase activity|nicotinamide mononucleotide deamidase activity MetaCyc:NMNAMIDOHYDRO-RXN|RHEA:12400|EC:3.5.1.42 molecular_function owl:Class
GO:0019560 biolink:NamedThing histidine catabolic process to hydantoin-5-propionate The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate. got7fsn_ti histidine degradation to hydantoin-5-propionate|histidine breakdown to hydantoin-5-propionate MetaCyc:HISHP-PWY biological_process owl:Class
GO:0032067 biolink:NamedThing type IV site-specific deoxyribonuclease activity Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated). got7fsn_ti type IV restriction enzyme activity molecular_function owl:Class
GO:0018478 biolink:NamedThing malonate-semialdehyde dehydrogenase (acetylating) activity Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+. got7fsn_ti malonic semialdehyde oxidative decarboxylase activity|3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating) EC:1.2.1.18|RHEA:22988|MetaCyc:1.2.1.18-RXN molecular_function owl:Class
GO:0002486 biolink:NamedThing antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules. got7fsn_ti endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent|TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway|TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway biological_process owl:Class
GO:0033257 biolink:NamedThing Bcl3/NF-kappaB2 complex A protein complex containing one Bcl protein and one or more copies of NF-kappaB2; formation of complexes of different stoichiometry depends on the Bcl3:NF-kappaB2 ratio, and allow Bcl3 to exert different regulatory effects on NF-kappaB2-dependent transcription. got7fsn_ti Bcl3-p52 complex|Bcl3-NFKB2 complex cellular_component owl:Class
GO:0033256 biolink:NamedThing I-kappaB/NF-kappaB complex A protein complex containing an inhibitory-kappaB (I-kappaB/IKB) protein and one or more copies of an NF-kappaB protein. In the resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. got7fsn_ti cellular_component owl:Class
GO:0102410 biolink:NamedThing quercetin-4',3-O-glucosyltransferase activity Catalysis of the reaction: quercetin 4'-O-glucoside + UDP-alpha-D-glucose(2-) <=> quercetin 3,4'-O-diglucoside + UDP(3-). got7fsn_ti MetaCyc:RXN-13765 molecular_function owl:Class
GO:0043702 biolink:NamedThing carotenoid vesicle A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vesicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance. got7fsn_ti cellular_component owl:Class
GO:0102572 biolink:NamedThing N-glutamylanilide hydrolase activity Catalysis of the reaction: N5-phenyl-L-glutamine + H2O = L-glutamate + aniline + H+. got7fsn_ti MetaCyc:RXN-15251|RHEA:50684 molecular_function owl:Class
GO:0033929 biolink:NamedThing blood-group-substance endo-1,4-beta-galactosidase activity Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in blood group A and B substances. got7fsn_ti blood-group-substance 1,4-beta-D-galactanohydrolase activity|endo-beta-galactosidase activity MetaCyc:3.2.1.102-RXN|EC:3.2.1.102 molecular_function owl:Class
GO:0004039 biolink:NamedThing allophanate hydrolase activity Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+). got7fsn_ti allophanate lyase activity|urea-1-carboxylate amidohydrolase activity MetaCyc:ALLOPHANATE-HYDROLASE-RXN|UM-BBD_reactionID:r0848|KEGG_REACTION:R00005|EC:3.5.1.54|RHEA:19029 molecular_function owl:Class
GO:0061587 biolink:NamedThing transfer RNA gene-mediated silencing The chromatin silencing that results in the inhibition of RNA polymerase II-transcribed genes located in the vicinity of tRNA genes. got7fsn_ti transfer RNA gene-mediated gene silencing|tRNA gene-mediated gene silencing|transfer RNA gene-mediated chromatin silencing|tRNA gene-mediated chromatin silencing|tgm silencing https://github.com/geneontology/go-ontology/issues/22060 dph 2014-02-05T09:03:59Z biological_process owl:Class
GO:0050785 biolink:NamedThing advanced glycation end-product receptor activity Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins). got7fsn_ti AGE receptor activity|RAGE activity molecular_function owl:Class
GO:0019034 biolink:NamedThing viral replication complex Specific locations and structures in the virus infected cell involved in replicating the viral genome. got7fsn_ti cellular_component owl:Class
GO:1900583 biolink:NamedThing o-orsellinic acid catabolic process The chemical reactions and pathways resulting in the breakdown of o-orsellinic acid. got7fsn_ti o-orsellinic acid breakdown|o-orsellinic acid catabolism|o-orsellinic acid degradation di 2012-05-15T06:48:04Z biological_process owl:Class
GO:1990927 biolink:NamedThing calcium ion regulated lysosome exocytosis The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels. got7fsn_ti sp 2016-02-16T14:19:44Z biological_process owl:Class
GO:0003847 biolink:NamedThing 1-alkyl-2-acetylglycerophosphocholine esterase activity Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. got7fsn_ti LDL-associated phospholipase A2|platelet-activating factor acetylhydrolase activity|alkylacetyl-GPC:acetylhydrolase activity|1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity|2-acetyl-1-alkylglycerophosphocholine esterase activity|1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity|LDL-PLA(2) activity|PAF 2-acylhydrolase activity|PAF acetylhydrolase activity|LDL-PLA2|LDL-associated phospholipase A(2) activity MetaCyc:3.1.1.47-RXN|Reactome:R-HSA-8869206|RHEA:17777|EC:3.1.1.47 molecular_function owl:Class
GO:0030546 biolink:NamedThing signaling receptor activator activity The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased. got7fsn_ti receptor activator activity|signalling receptor activator activity molecular_function owl:Class
GO:0046569 biolink:NamedThing glyoxal oxidase activity Catalysis of the reaction: glyoxal + O2 + H2O = glyoxalate + H2O2. got7fsn_ti GLOX molecular_function owl:Class
GO:0052758 biolink:NamedThing coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction. got7fsn_ti coenzyme F420-dependent 2,4,6-trinitrophenol hydride transferase activity|TNP reductase activity ai 2011-09-28T11:06:03Z UM-BBD_reactionID:r1065|EC:1.3.99.- molecular_function owl:Class
GO:0099620 biolink:NamedThing UDP-4-amino-4-deoxy-L-arabinose aminotransferase Catalysis of the reaction: UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 2-oxoglutarate = UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate. got7fsn_ti UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase|UDP-L-Ara4N transaminase|UDP-4-amino-4-deoxy-beta-L-arabinose:2-oxoglutarate aminotransferase|UDP-4-amino-4-deoxy-L-arabinose---oxoglutarate aminotransferase|UDP-Ara4O aminotransferase EC:2.6.1.87|RHEA:24710 molecular_function owl:Class
GO:0018502 biolink:NamedThing 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone. got7fsn_ti UM-BBD_reactionID:r0553|RHEA:15741|MetaCyc:LINC-RXN molecular_function owl:Class
GO:0005873 biolink:NamedThing plus-end kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule. got7fsn_ti cellular_component owl:Class
GO:0070226 biolink:NamedThing sulfur:ferric ion oxidoreductase activity Catalysis of the reaction: a perthiol + 4 Fe3+ + 3 H2O = sulfite + a thiol + 4 Fe2+ + 8 H+. got7fsn_ti hydrogen sulfide:ferric ion oxidoreductase MetaCyc:SULFFEOXIDO-RXN molecular_function owl:Class
GO:0043811 biolink:NamedThing phosphate:acyl-[acyl carrier protein] acyltransferase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]. got7fsn_ti molecular_function owl:Class
GO:1990769 biolink:NamedThing proximal neuron projection The portion of an axon or dendrite that is close to the neuronal cell body. got7fsn_ti sl 2015-06-10T20:30:40Z cellular_component owl:Class
GO:1902795 biolink:NamedThing heterochromatin domain assembly The aggregation, arrangement and bonding together of a set of components to form a heterochromatin domain. got7fsn_ti HOOD formation|heterochromatin domain formation|HOOD assembly mah 2014-03-24T12:46:56Z biological_process owl:Class
GO:0098623 biolink:NamedThing selenite reductase activity Catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O. got7fsn_ti Reactome:R-HSA-2408558 molecular_function owl:Class
GO:0035610 biolink:NamedThing protein side chain deglutamylation The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation. got7fsn_ti shortening of glutamate side chain|removal of posttranslational polyglutamylation bf 2010-11-18T01:09:03Z biological_process owl:Class
GO:0018870 biolink:NamedThing anaerobic 2-aminobenzoate metabolic process The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen. got7fsn_ti anaerobic 2-aminobenzoate metabolism UM-BBD_pathwayID:abz biological_process owl:Class
GO:0035836 biolink:NamedThing ergot alkaloid metabolic process The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid. got7fsn_ti ergot alkaloid metabolism bf 2011-05-04T03:23:13Z biological_process owl:Class
GO:1990783 biolink:NamedThing periphagosomal region of cytoplasm Cytoplasm situated near, or occurring around, a phagosome. got7fsn_ti sl 2015-06-23T21:46:10Z cellular_component owl:Class
GO:0036325 biolink:NamedThing vascular endothelial growth factor receptor-3 signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. got7fsn_ti VEGFR3 signaling pathway|FLT4 signaling pathway|VEGFR-3 signaling pathway bf 2012-09-04T15:25:13Z biological_process owl:Class
GO:0070034 biolink:NamedThing telomerase RNA binding Binding to the telomerase RNA template. got7fsn_ti TERC binding molecular_function owl:Class
GO:0001537 biolink:NamedThing N-acetylgalactosamine 4-O-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. got7fsn_ti N-acetylgalactosamine 4-O-sulphotransferase activity Reactome:R-HSA-3636919|Reactome:R-HSA-2022063|Reactome:R-HSA-6786034 molecular_function owl:Class
GO:0047046 biolink:NamedThing homoisocitrate dehydrogenase activity Catalysis of the reaction: NAD+ + 3-carboxy-2-hydroxyadipate = NADH + H+ + CO2 + 2-keto-adipate. got7fsn_ti 2-hydroxy-3-carboxyadipate dehydrogenase activity|3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating)|(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD(+) oxidoreductase (decarboxylating) activity|(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating)|3-carboxy-2-hydroxyadipate dehydrogenase activity|(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)|homoisocitric dehydrogenase activity|3-carboxy-2-hydroxyadipate:NAD(+) oxidoreductase (decarboxylating) activity Note that EC:1.1.1.155 was merged into EC:1.1.1.87 as they are identical. GO:0047984 RHEA:11900|EC:1.1.1.87|MetaCyc:1.1.1.87-RXN molecular_function owl:Class
GO:0102496 biolink:NamedThing GA5 2,3 epoxidase activity Catalysis of the reaction: gibberellin A5 + O2 + 2-oxoglutarate <=> gibberellin A6 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-14327 molecular_function owl:Class
GO:0098686 biolink:NamedThing hippocampal mossy fiber to CA3 synapse One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. got7fsn_ti dos 2017-02-05T16:29:58Z cellular_component owl:Class
GO:0002359 biolink:NamedThing B-1 B cell proliferation The expansion of a B-1 B cell by cell division. Follows B cell activation. got7fsn_ti B-1 B-cell proliferation|B-1 B-lymphocyte proliferation|B-1 B lymphocyte proliferation biological_process owl:Class
GO:0018487 biolink:NamedThing vanillate O-demethylase (anaerobic) activity Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate. got7fsn_ti UM-BBD_reactionID:r0758 molecular_function owl:Class
GO:0050458 biolink:NamedThing decylhomocitrate synthase activity Catalysis of the reaction: 2-oxoglutarate + H(2)O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+). got7fsn_ti 3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acylating) activity|dodecanoyl-CoA:2-oxoglutarate C-dodecanoyltransferase (thioester-hydrolysing, 1-carboxyundecyl-forming)|2-decylhomocitrate synthase activity|3-hydroxytetradecane-1,3,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acylating) KEGG_REACTION:R03859|EC:2.3.3.4|RHEA:10364|MetaCyc:DECYLHOMOCITRATE-SYNTHASE-RXN molecular_function owl:Class
GO:0097048 biolink:NamedThing dendritic cell apoptotic process Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. got7fsn_ti dendritic cell apoptosis pr 2011-05-04T02:18:59Z biological_process owl:Class
GO:0031208 biolink:NamedThing POZ domain binding Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors. got7fsn_ti BTB domain|broad-complex, tramtrack, and bric-a-brac domain binding molecular_function owl:Class
GO:0018736 biolink:NamedThing 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA. got7fsn_ti UM-BBD_reactionID:r0206 molecular_function owl:Class
GO:0071488 biolink:NamedThing cellular response to very low light intensity stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low light intensity stimulus. A very low light intensity stimulus is defined as a level of electromagnetic radiation below 0.001 mmol/m2/sec. got7fsn_ti mah 2009-12-18T02:13:40Z biological_process owl:Class
GO:0036227 biolink:NamedThing mitotic G2 cell cycle arrest in response to glucose starvation The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose. got7fsn_ti bf 2012-05-09T02:45:49Z biological_process owl:Class
GO:0047842 biolink:NamedThing dehydro-L-gulonate decarboxylase activity Catalysis of the reaction: 3-dehydro-L-gulonate + H(+) = L-xylulose + CO(2). got7fsn_ti keto-L-gulonate decarboxylase activity|3-dehydro-L-gulonate carboxy-lyase activity|3-dehydro-L-gulonate carboxy-lyase (L-xylulose-forming)|3-keto-L-gulonate decarboxylase activity MetaCyc:DEHYDRO-L-GULONATE-DECARBOXYLASE-RXN|Reactome:R-HSA-5662473|EC:4.1.1.34|KEGG_REACTION:R01905|RHEA:11084 molecular_function owl:Class
GO:0052594 biolink:NamedThing aminoacetone:oxygen oxidoreductase(deaminating) activity Catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+. got7fsn_ti MetaCyc:AMACETOXID-RXN|RHEA:28186|KEGG_REACTION:R02529|EC:1.4.3.21 molecular_function owl:Class
GO:0043464 biolink:NamedThing malolactic fermentation The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP. got7fsn_ti L-malate fermentation|malo-lactate fermentation|malate fermentation|malolactate fermentation Wikipedia:Malolactic_fermentation biological_process owl:Class
GO:0070690 biolink:NamedThing L-threonine catabolic process to acetyl-CoA The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA. got7fsn_ti L-threonine degradation to acetyl-CoA|L-threonine breakdown to acetyl-CoA|L-threonine catabolism to acetyl-CoA|threonine catabolic process to acetyl-CoA mah 2009-06-03T01:40:22Z MetaCyc:PWY-5436 biological_process owl:Class
GO:0042137 biolink:NamedThing sequestering of neurotransmitter The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system. got7fsn_ti neurotransmitter sequestration|sequestration of neurotransmitter|retention of neurotransmitter|neurotransmitter biosynthetic process and storage|neurotransmitter biosynthesis and storage|neurotransmitter retention|neurotransmitter storage|storage of neurotransmitter biological_process owl:Class
GO:0047308 biolink:NamedThing alanine-oxomalonate transaminase activity Catalysis of the reaction: L-alanine + oxomalonate = aminomalonate + pyruvate. got7fsn_ti alanine-oxomalonate aminotransferase activity|L-alanine:oxomalonate aminotransferase activity|alanine--oxomalonate aminotransferase activity|L-alanine-ketomalonate transaminase activity|alanine-ketomalonate (mesoxalate) transaminase activity KEGG_REACTION:R02970|RHEA:18809|MetaCyc:2.6.1.47-RXN|EC:2.6.1.47 molecular_function owl:Class
GO:0097362 biolink:NamedThing MCM8-MCM9 complex A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links. got7fsn_ti pr 2012-07-20T02:10:12Z cellular_component owl:Class
GO:0052725 biolink:NamedThing inositol-1,3,4-trisphosphate 6-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+). got7fsn_ti ATP:1D-myo-inositol-1,3,4-trisphosphate 6-phosphotransferase activity|IP3 6-kinase activity|Ins(1,3,4)P3 6-kinase activity|inositol-trisphosphate 6-kinase activity|inositol 1,3,4-trisphosphate 6-kinase activity|1D-myo-inositol-trisphosphate 6-kinase activity|ins(1,3,4)P(3) 6-kinase activity ai 2011-08-16T12:42:59Z Reactome:R-HSA-1855197|EC:2.7.1.159|MetaCyc:2.7.1.133-RXN|RHEA:20940|Reactome:R-HSA-2267372 molecular_function owl:Class
GO:0002333 biolink:NamedThing transitional one stage B cell differentiation The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21. got7fsn_ti transitional one stage B cell development|transitional one stage B-lymphocyte differentiation|transitional one stage B-cell differentiation|transitional one stage B lymphocyte differentiation|T1 stage B cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0018509 biolink:NamedThing cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+. got7fsn_ti biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity|2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity|cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity MetaCyc:1.3.1.56-RXN|RHEA:17033|UM-BBD_enzymeID:e0134|EC:1.3.1.56 molecular_function owl:Class
GO:0047092 biolink:NamedThing 27-hydroxycholesterol 7-alpha-monooxygenase activity Catalysis of the reaction: O2 + NADPH + 27-hydroxycholesterol = H2O + NADP+ + 7-alpha,27-dihydroxycholesterol. got7fsn_ti 27-hydroxycholesterol 7alpha-monooxygenase activity|27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)|27-hydroxycholesterol 7a-hydroxylase activity|27-hydroxycholesterol 7alpha-hydroxylase activity|27-hydroxycholesterol 7-alpha-hydroxylase activity MetaCyc:1.14.13.60-RXN|RHEA:24308|EC:1.14.14.29 molecular_function owl:Class
GO:0002126 biolink:NamedThing instrumental aggressive behavior Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation. got7fsn_ti instrumental aggression biological_process owl:Class
GO:0061832 biolink:NamedThing basal ectoplasmic specialization Testis-specific junction between mature Sertoli cells involved in establishing the blood-testis barrier of the Sertoli cell. got7fsn_ti basal ES cellular_component owl:Class
GO:0034361 biolink:NamedThing very-low-density lipoprotein particle A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. got7fsn_ti VLDL complex|very-low-density lipoprotein complex|VLDL particle cellular_component owl:Class
GO:0000172 biolink:NamedThing ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. got7fsn_ti ribonuclease mitochondrial RNA processing complex|RNase MRP complex cellular_component owl:Class
GO:0010736 biolink:NamedThing serum response element binding Binding to a serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. got7fsn_ti Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. molecular_function owl:Class
GO:0102302 biolink:NamedThing mycinamicin VI 2''-O-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + mycinamicin VI <=> S-adenosyl-L-homocysteine + mycinamicin III(1+) + H+. got7fsn_ti MetaCyc:RXN-12801|RHEA:31643|EC:2.1.1.238 molecular_function owl:Class
GO:0008231 biolink:NamedThing repressor ecdysone receptor complex A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes. got7fsn_ti repressor ecdysone receptor holocomplex cellular_component owl:Class
GO:0047406 biolink:NamedThing beta-aspartyl-N-acetylglucosaminidase activity Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-D-glucosamine + L-asparagine. got7fsn_ti 1-beta-aspartyl-N-acetyl-D-glucosaminylamine L-asparaginohydrolase activity|beta-aspartylacetylglucosaminidase activity KEGG_REACTION:R01266|MetaCyc:3.2.2.11-RXN|EC:3.2.2.11|RHEA:12324 molecular_function owl:Class
GO:1904666 biolink:NamedThing regulation of ubiquitin protein ligase activity Any process that modulates the frequency, rate or extent of ubiquitin protein ligase activity. got7fsn_ti regulation of protein ubiquitination activity|regulation of APC-fizzy related complex activity|regulation of ubiquitin ligase activity|regulation of E3 dph 2015-09-08T15:26:59Z GO:1903834 biological_process owl:Class
GO:0051438 biolink:NamedThing regulation of ubiquitin-protein transferase activity Any process that modulates the frequency, rate or extent of ubiquitin transferase activity. got7fsn_ti ubiquitin transferase regulator|anaphase-promoting complex regulator|ubiquitin-protein transferase regulator|APC regulator|SCF complex regulator|regulation of ubiquitin transferase activity biological_process owl:Class
GO:0102692 biolink:NamedThing benzyladenine UDP glycosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + N-benzyl-9-(alpha-D-glucosyl)adenine + UDP. got7fsn_ti MetaCyc:RXN-4730 molecular_function owl:Class
GO:0048061 biolink:NamedThing positive gravitaxis The directed movement of a motile cell or organism towards the source of gravity. got7fsn_ti positive taxis in response to gravitytaxis in response to gravitational stimulus|positive geotactic behavior|positive geotactic behaviour|positive gravitactic behaviour|positive taxis in response to gravity|positive gravitactic behavior GO:0048064 biological_process owl:Class
GO:0102525 biolink:NamedThing 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity Catalysis of the reaction: L-argininium(1+) + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-arginine(1+) + succinate + carbon dioxide. got7fsn_ti EC:1.14.11.41|RHEA:36607|MetaCyc:RXN-14542 molecular_function owl:Class
GO:0033553 biolink:NamedThing rDNA heterochromatin A region of heterochromatin located at the rDNA repeats in a chromosome. got7fsn_ti ribosomal DNA heterochromatin of nucleus|ribosomal DNA heterochromatin of cell nucleus|nuclear rDNA heterochromatin|ribosomal DNA heterochromatin GO:1902377 cellular_component owl:Class
GO:0047789 biolink:NamedThing creatininase activity Catalysis of the reaction: creatinine + H(2)O = creatine. got7fsn_ti creatinine amidohydrolase activity|creatinine hydrolase EC:3.5.2.10|RHEA:14533|MetaCyc:CREATININASE-RXN|KEGG_REACTION:R01884 molecular_function owl:Class
GO:0005122 biolink:NamedThing torso binding Binding to a torso (tor) protein, a receptor tyrosine kinase. got7fsn_ti torso ligand|tor ligand|tor binding molecular_function owl:Class
GO:0003834 biolink:NamedThing beta-carotene 15,15'-dioxygenase activity Catalysis of the reaction: all-trans-beta-carotene + O2 = 2 all-trans-retinal. got7fsn_ti carotene dioxygenase activity|beta-carotene 15,15'-monooxygenase activity|carotene 15,15'-dioxygenase activity https://github.com/geneontology/go-ontology/issues/21765 Formerly EC:1.13.11.n2, EC:1.13.11.21 and then EC 1.14.99.36. RHEA:32887|MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN|KEGG_REACTION:R00032|EC:1.13.11.63|Reactome:R-HSA-975635 molecular_function owl:Class
GO:0072574 biolink:NamedThing hepatocyte proliferation The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. got7fsn_ti mah 2011-02-02T03:34:49Z biological_process owl:Class
GO:0072575 biolink:NamedThing epithelial cell proliferation involved in liver morphogenesis The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the liver. got7fsn_ti mah 2011-02-02T03:37:50Z biological_process owl:Class
GO:0047937 biolink:NamedThing glucose-1-phosphate phosphodismutase activity Catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate. got7fsn_ti phosphodismutase activity|glucose 1-phosphate transphosphorylase activity|D-glucose-1-phosphate:D-glucose-1-phosphate 6-phosphotransferase activity MetaCyc:GLUCOSE-1-PHOSPHATE-PHOSPHODISMUTASE-RXN|RHEA:16397|EC:2.7.1.41 molecular_function owl:Class
GO:0042207 biolink:NamedThing styrene catabolic process The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene. got7fsn_ti styrene breakdown|styrene catabolism|styrene degradation UM-BBD_pathwayID:sty biological_process owl:Class
GO:0032003 biolink:NamedThing interleukin-28 receptor binding Binding to an interleukin-28 receptor. got7fsn_ti interleukin-28 receptor ligand|IL-28 molecular_function owl:Class
GO:1990481 biolink:NamedThing mRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine in an mRNA molecule. got7fsn_ti mRNA pseudouridylation mcc 2014-09-12T15:13:39Z biological_process owl:Class
GO:0001714 biolink:NamedThing endodermal cell fate specification The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. got7fsn_ti endoderm cell fate specification biological_process owl:Class
GO:0034811 biolink:NamedThing benzo(a)pyrene 9,10-dioxygenase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol. got7fsn_ti UM-BBD_reactionID:r1132|EC:1.13.11.- molecular_function owl:Class
GO:0140365 biolink:NamedThing RNP body A ribonucleoprotein granule located in the cytoplasm of bacteria, minimally containing the RNase E protein and RNA molecules. Bacterial RNP-bodies are similar to eukaryotic P-bodies and stress granules. got7fsn_ti BR-body pg 2019-07-25T19:31:17Z cellular_component owl:Class
GO:0060305 biolink:NamedThing regulation of cell diameter Any process that modulates the diameter of a cell, the length of a line segment that crosses through the center of a circular section through a cell. got7fsn_ti regulation of cell width biological_process owl:Class
GO:0018700 biolink:NamedThing 2-chloro-N-isopropylacetanilide reductive dehalogenase activity Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide. got7fsn_ti EC:1.97.1.-|UM-BBD_reactionID:r0719 molecular_function owl:Class
GO:0035339 biolink:NamedThing SPOTS complex A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis. got7fsn_ti serine palmitoyltransferase, Orm1/2, Tsc3 and Sac1 complex bf 2010-03-03T10:28:42Z cellular_component owl:Class
GO:0030507 biolink:NamedThing spectrin binding Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. got7fsn_ti molecular_function owl:Class
GO:0102846 biolink:NamedThing 1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity Catalysis of the reaction: 1-18:3-2-16:1-monogalactosyldiacylglycerol + O2 + a reduced electron acceptor <=> 1-18:3-2-16:2-monogalactosyldiacylglycerol + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8308 molecular_function owl:Class
GO:0034004 biolink:NamedThing germacradienol synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate. got7fsn_ti 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming] activity KEGG_REACTION:R07647|RHEA:22436|MetaCyc:RXN-8648|EC:4.2.3.22 molecular_function owl:Class
GO:0061801 biolink:NamedThing laminin-5B complex A laminin complex composed of alpha3B, beta3 and gamma2 polypeptide chains. got7fsn_ti laminin 3B32 complex dph 2016-10-26T15:05:15Z cellular_component owl:Class
GO:0102630 biolink:NamedThing gossypetin 8-methyl ester 3'-O-methyltransferase activity Catalysis of the reaction: 3',4',5,7-pentahydroxy-8-methoxyflavon-3-olate + S-adenosyl-L-methionine <=> gossypetin 3',8-dimethyl ether + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-15536 molecular_function owl:Class
GO:0102443 biolink:NamedThing L-2-hydroxycarboxylate dehydrogenase (NAD+) activity Catalysis of the reaction: NAD(1-) + a (2S)-2-hydroxycarboxylate <=> NADH(2-) + H+ + a 2-oxo carboxylate. got7fsn_ti MetaCyc:RXN-13927|EC:1.1.1.337|RHEA:34555 molecular_function owl:Class
GO:0060075 biolink:NamedThing regulation of resting membrane potential Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized. got7fsn_ti regulation of resting potential biological_process owl:Class
GO:0019247 biolink:NamedThing lactate racemization Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture. got7fsn_ti biological_process owl:Class
GO:0098746 biolink:NamedThing fast, calcium ion-dependent exocytosis of neurotransmitter The fast, initial phase of calcium ion-induced neurotransmitter release, via exocytosis, into the synaptic cleft. This depends on low affinity calcium sensors and typically begins a fraction of a millisecond after Ca2+ influx, and decays rapidly (1-10ms) with a decay constant of around 5-10ms. The underlying molecular mechanisms of this process are distinct from those of the later, slow phase of release. got7fsn_ti synchronous, calcium ion-dependent exocytosis of neurotransmitter biological_process owl:Class
GO:0033911 biolink:NamedThing mycodextranase activity Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in alpha-D-glucans containing both 1,3- and 1,4-bonds. got7fsn_ti 1,3-1,4-alpha-D-glucan 4-glucanohydrolase activity EC:3.2.1.61|MetaCyc:3.2.1.61-RXN molecular_function owl:Class
GO:0051612 biolink:NamedThing negative regulation of serotonin uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell. got7fsn_ti down regulation of serotonin uptake|down-regulation of serotonin uptake|negative regulation of 5-hydroxytryptamine uptake|negative regulation of serotonin import|downregulation of serotonin uptake|negative regulation of 5-HT uptake|negative regulation of 5HT uptake biological_process owl:Class
GO:1905348 biolink:NamedThing endonuclease complex A protein complex which is capable of endonuclease activity. got7fsn_ti An example of this is MUS81 in human (Q96NY9) in PMID:18413719 (inferred from direct assay). bhm 2016-08-03T12:27:00Z cellular_component owl:Class
GO:0043863 biolink:NamedThing 4-hydroxy-2-ketopimelate aldolase activity Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate. got7fsn_ti 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase activity|HpcH|HHED aldolase activity|HpaI RHEA:25788|MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN molecular_function owl:Class
GO:0030367 biolink:NamedThing interleukin-17 receptor binding Binding to an interleukin-17 receptor. got7fsn_ti interleukin-17 receptor ligand|IL-17 molecular_function owl:Class
GO:0004339 biolink:NamedThing glucan 1,4-alpha-glucosidase activity Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. got7fsn_ti exo-1,4-alpha-glucosidase activity|lysosomal alpha-glucosidase activity|gamma-amylase activity|gamma-1,4-glucan glucohydrolase activity|glucose amylase activity|glucoamylase activity|1,4-alpha-D-glucan glucohydrolase activity|amyloglucosidase activity Note that this term is not a child of 'alpha-glucosidase activity ; GO:0090599', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0090599 alpha-D-glucose is released. EC:3.2.1.3|MetaCyc:3.2.1.3-RXN molecular_function owl:Class
GO:0034022 biolink:NamedThing 3-(hydroxyamino)phenol mutase activity Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone. got7fsn_ti 3HAP mutase activity|3-hydroxylaminophenol mutase activity|3-(hydroxyamino)phenol hydroxymutase activity MetaCyc:5.4.4.3-RXN|RHEA:20577|EC:5.4.4.3|KEGG_REACTION:R06988|UM-BBD_enzymeID:e0953 molecular_function owl:Class
GO:0047776 biolink:NamedThing citramalate lyase activity Catalysis of the reaction: S-citramalate = acetate + pyruvate. got7fsn_ti (+)-citramalate pyruvate-lyase activity|(3S)-citramalate pyruvate-lyase (acetate-forming)|citramalate synthetase activity|citramalate pyruvate lyase activity|(S)-citramalate lyase activity|citramalic synthase activity|(3S)-citramalate pyruvate-lyase activity|citramalic-condensing enzyme|citramalate pyruvate-lyase activity MetaCyc:CITRAMALATE-LYASE-RXN|RHEA:15545|KEGG_REACTION:R00325|EC:4.1.3.22 molecular_function owl:Class
GO:0050553 biolink:NamedThing taxadiene synthase activity Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene. got7fsn_ti geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxa-4,11-diene-forming)|geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, taxadiene-forming)|taxa-4(5),11(12)-diene synthase activity RHEA:20912|KEGG_REACTION:R06305|EC:4.2.3.17|MetaCyc:4.2.3.17-RXN molecular_function owl:Class
GO:0060758 biolink:NamedThing foraging behavior by probing substrate Foraging behavior in which an anatomical part of the organism is inserted into the substrate to locate food. got7fsn_ti dph 2009-06-22T02:53:09Z biological_process owl:Class
GO:0043491 biolink:NamedThing protein kinase B signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. got7fsn_ti PKB signalling cascade|PKB signaling cascade|AKT signaling|AKT signalling cascade|AKT signal transduction|protein kinase B signaling cascade|protein kinase B signal transduction|AKT signaling cascade|PKB signal transduction|protein kinase B signalling cascade|PKB signaling biological_process owl:Class
GO:0034849 biolink:NamedThing 2-naphthoate CoA-transferase activity Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH. got7fsn_ti UM-BBD_reactionID:r1262 molecular_function owl:Class
GO:0052731 biolink:NamedThing phosphocholine phosphatase activity Catalysis of the reaction: choline phosphate + H2O = choline + phosphate. got7fsn_ti PHOSPHO1|phosphoethanolamine phosphohydrolase activity|3X11A ai 2011-08-16T04:09:06Z Reactome:R-HSA-1483159|MetaCyc:RXN-5647|KEGG_REACTION:R06871|RHEA:10492|EC:3.1.3.75 molecular_function owl:Class
GO:0044778 biolink:NamedThing meiotic DNA integrity checkpoint signaling A signal transduction process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA during meiosis. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction. got7fsn_ti meiotic DNA integrity checkpoint https://github.com/geneontology/go-ontology/issues/20935 jl 2013-03-20T16:46:06Z biological_process owl:Class
GO:0103045 biolink:NamedThing methione N-acyltransferase activity Catalysis of the reaction: L-methionine + acetyl-CoA = N-acetyl-L-methionine + coenzyme A + H+. got7fsn_ti RHEA:44144|EC:2.3.1.1|MetaCyc:RXN0-6948 molecular_function owl:Class
GO:0050181 biolink:NamedThing phorbol-diester hydrolase activity Catalysis of the reaction: H(2)O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate. got7fsn_ti diacylphorbate 12-hydrolase activity|phorbol-12,13-diester 12-ester hydrolase activity|PDEH|12,13-diacylphorbate 12-acylhydrolase activity KEGG_REACTION:R04119|RHEA:21316|MetaCyc:PHORBOL-DIESTER-HYDROLASE-RXN|EC:3.1.1.51 molecular_function owl:Class
GO:1905368 biolink:NamedThing peptidase complex A protein complex which is capable of peptidase activity. got7fsn_ti tryptase complex|protease complex An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay). bhm 2016-08-16T12:49:36Z cellular_component owl:Class
GO:0036428 biolink:NamedThing adenosylcobinamide kinase (GTP-specific) activity Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+. got7fsn_ti bf 2013-09-16T14:05:39Z RHEA:15765|KEGG_REACTION:R06558|MetaCyc:RXN-14063 molecular_function owl:Class
GO:1990601 biolink:NamedThing 5' overhang single-stranded DNA endodeoxyribonuclease activity Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks. got7fsn_ti al 2015-01-06T16:24:39Z molecular_function owl:Class
GO:2001030 biolink:NamedThing negative regulation of cellular glucuronidation Any process that stops, prevents or reduces the frequency, rate or extent of cellular glucuronidation. got7fsn_ti negative regulation of cellular glucuronoside biosynthesis|negative regulation of cellular glucuronide biosynthetic process|negative regulation of cellular glucuronoside biosynthetic process|negative regulation of cellular glucuronide biosynthesis rl 2011-08-22T01:10:56Z biological_process owl:Class
GO:0033997 biolink:NamedThing inulin fructotransferase (DFA-I-forming) activity Catalysis of the reaction: [(2->1)-beta-D-fructosyl](n) = [(2->1)-beta-D-fructosyl](n-1) + alpha-D-fructofuranose-beta-D-fructofuranose 1,2':1,2'-dianhydride. This reaction is the production of alpha-D-fructofuranose beta-D-fructofuranose 1,2':2,1'-dianhydride (DFA I) by successively eliminating the diminishing (2->1)-beta-D-fructan (inulin) chain from the terminal D-fructosyl-D-fructosyl disaccharide. got7fsn_ti 2,1-beta-D-fructan lyase (alpha-D-fructofuranose-beta-D-fructofuranose-1,2':2,1'-dianhydride-forming) activity|inulin D-fructosyl-D-fructosyltransferase (forming alpha-D-fructofuranose beta-D-fructofuranose 1,2':1',2-dianhydride) activity|inulin fructotransferase (DFA-I-producing) activity|inulin D-fructosyl-D-fructosyltransferase (1,2':1',2-dianhydride-forming) activity|inulin fructotransferase (depolymerizing, difructofuranose-1,2':2',1-dianhydride-forming) activity EC:4.2.2.17|MetaCyc:4.2.2.17-RXN molecular_function owl:Class
GO:0018270 biolink:NamedThing GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein. got7fsn_ti GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine|GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine|GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine RESID:AA0163 biological_process owl:Class
GO:0036412 biolink:NamedThing acetyl-CoA:oxalate CoA-transferase Catalysis of the reaction: acetyl-CoA + oxalate = acetate + oxalyl-CoA. got7fsn_ti bf 2013-08-22T13:43:25Z RHEA:37883 molecular_function owl:Class
GO:1903503 biolink:NamedThing ATPase inhibitor complex A protein complex which is capable of ATPase inhibitor activity. got7fsn_ti An example of this is Mago in drome (P49028) in PMID:16170325 (inferred from direct assay). bhm 2014-09-30T13:55:37Z cellular_component owl:Class
GO:0072219 biolink:NamedThing metanephric cortical collecting duct development The process whose specific outcome is the progression of the metanephric cortical collecting duct over time, from its formation to the mature structure. The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex. got7fsn_ti mah 2010-03-18T03:34:52Z biological_process owl:Class
GO:0018796 biolink:NamedThing 4,5-dihydroxyphthalate decarboxylase activity Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2. got7fsn_ti 4,5-dihydroxyphthalate carboxy-lyase activity|4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming) MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN|UM-BBD_enzymeID:e0106|EC:4.1.1.55|RHEA:24184 molecular_function owl:Class
GO:0047072 biolink:NamedThing 2,3-dihydroxybenzoate 2,3-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-carboxy-cis,cis-muconate + 2 H(+). got7fsn_ti 2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing)|2,3-dihydroxybenzoate 2,3-oxygenase activity RHEA:15369|MetaCyc:1.13.11.28-RXN|KEGG_REACTION:R01506|EC:1.13.11.28 molecular_function owl:Class
GO:0043738 biolink:NamedThing reduced coenzyme F420 dehydrogenase activity Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420. got7fsn_ti F420H2 dehydrogenase activity|1,5-dihydrocoenzyme F420 dehydrogenase activity MetaCyc:RXN-8106|EC:1.5.98.3|RHEA:54752 molecular_function owl:Class
NCBITaxon:1 biolink:NamedThing got7fsn_ti owl:Class
OBI:0100026 biolink:NamedThing got7fsn_ti owl:Class
GO:0009550 biolink:NamedThing primary plasmodesma A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis. got7fsn_ti simple plasmodesma cellular_component owl:Class
GO:0031891 biolink:NamedThing type 1 vasoactive intestinal polypeptide receptor binding Binding to a type 1 vasoactive intestinal polypeptide receptor. got7fsn_ti type 2 PACAP receptor binding|type 1 vasoactive intestinal polypeptide receptor ligand molecular_function owl:Class
GO:0031686 biolink:NamedThing A1 adenosine receptor binding Binding to an A1 adenosine receptor. got7fsn_ti A1 adenosine receptor ligand molecular_function owl:Class
GO:0043873 biolink:NamedThing pyruvate-flavodoxin oxidoreductase activity Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin. got7fsn_ti pyruvate:flavodoxin oxidoreductase activity|NifJ MetaCyc:PYFLAVOXRE-RXN|RHEA:44140 molecular_function owl:Class
GO:0018456 biolink:NamedThing aryl-alcohol dehydrogenase (NAD+) activity Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+. got7fsn_ti p-hydroxybenzyl alcohol dehydrogenase activity|aryl-alcohol:NAD+ oxidoreductase activity|benzyl alcohol dehydrogenase activity UM-BBD_enzymeID:e0019|MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN|EC:1.1.1.90|RHEA:12076 molecular_function owl:Class
GO:0098002 biolink:NamedThing receptor-mediated bacteriophage irreversible attachment to host cell The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell. got7fsn_ti phage irreversible adsorption|irreversible bacteriophage attachment, binding of host cell surface receptor bm biological_process owl:Class
GO:0030946 biolink:NamedThing protein tyrosine phosphatase activity, metal-dependent Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions. got7fsn_ti molecular_function owl:Class
GO:0102627 biolink:NamedThing parthenolide 3beta-hydroxylase activity Catalysis of the reaction: parthenolide + NADPH + O2 + H+ <=> 3beta-hydroxyparthenolide + NADP + H2O. got7fsn_ti MetaCyc:RXN-15532 molecular_function owl:Class
GO:0047729 biolink:NamedThing carnitine decarboxylase activity Catalysis of the reaction: carnitine + H(+) = 2-methylcholine + CO(2). got7fsn_ti carnitine carboxy-lyase (2-methylcholine-forming)|carnitine carboxy-lyase activity KEGG_REACTION:R02398|MetaCyc:CARNITINE-DECARBOXYLASE-RXN|RHEA:21576|EC:4.1.1.42 molecular_function owl:Class
GO:0033433 biolink:NamedThing AUU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes an AUU codon. got7fsn_ti isoleucine tRNA|ATT codon-amino acid adaptor activity Note that in the standard genetic code, ATT codes for isoleucine. molecular_function owl:Class
GO:0046486 biolink:NamedThing glycerolipid metabolic process The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis. got7fsn_ti glycerolipid metabolism biological_process owl:Class
GO:0008404 biolink:NamedThing arachidonic acid 14,15-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid. got7fsn_ti cytochrome P450 CYP2C39|cytochrome P450 CYP2C29 RHEA:51472 molecular_function owl:Class
GO:0003952 biolink:NamedThing NAD+ synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. got7fsn_ti NAD synthetase (glutamine-hydrolysing)|desamidonicotinamide adenine dinucleotide amidotransferase activity|NAD synthase (glutamine-hydrolyzing) activity|NAD(+) synthetase (glutamine-hydrolyzing) activity|nicotinamide adenine dinucleotide synthetase (glutamine) activity|DPN synthetase activity|NAD+ synthase (glutamine-hydrolysing)|deamido-NAD+:L-glutamine amido-ligase (AMP-forming)|NAD+ synthetase (glutamine-hydrolyzing) Wikipedia:NAD+_synthase_(glutamine-hydrolysing)|EC:6.3.5.1|RHEA:24384|MetaCyc:NAD-SYNTH-GLN-RXN|Reactome:R-HSA-197271 molecular_function owl:Class
GO:0043737 biolink:NamedThing deoxyribonuclease V activity Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate. got7fsn_ti DNase V activity|endodeoxyribonuclease V|Escherichia coli endodeoxyribonuclease V activity|endonuclease V activity MetaCyc:3.1.21.7-RXN|EC:3.1.21.7 molecular_function owl:Class
GO:0006664 biolink:NamedThing glycolipid metabolic process The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent. got7fsn_ti glycolipid metabolism biological_process owl:Class
GO:0008794 biolink:NamedThing arsenate reductase (glutaredoxin) activity Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione. got7fsn_ti glutharedoxin:arsenate oxidoreductase activity RHEA:22016|UM-BBD_reactionID:r0635|MetaCyc:RXN-982|EC:1.20.4.1 molecular_function owl:Class
GO:0018340 biolink:NamedThing peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine. got7fsn_ti peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine|peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine|peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine RESID:AA0264 biological_process owl:Class
GO:0031698 biolink:NamedThing beta-2 adrenergic receptor binding Binding to a beta-2 adrenergic receptor. got7fsn_ti beta-2 adrenergic receptor ligand molecular_function owl:Class
GO:0018404 biolink:NamedThing protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues. got7fsn_ti protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine RESID:AA0210 biological_process owl:Class
GO:0008405 biolink:NamedThing arachidonic acid 11,12-epoxygenase activity Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid. got7fsn_ti cytochrome P450 CYP2C38 RHEA:51480 molecular_function owl:Class
GO:0097127 biolink:NamedThing cyclin B3-CDK2 complex A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner. got7fsn_ti pr 2011-08-01T01:47:16Z cellular_component owl:Class
GO:0018490 biolink:NamedThing 4-hydroxyphenylpyruvate oxidase activity Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2). got7fsn_ti 4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating) KEGG_REACTION:R00042|RHEA:17197|EC:1.2.3.13|UM-BBD_reactionID:r0299|MetaCyc:1.2.3.13-RXN molecular_function owl:Class
GO:0102900 biolink:NamedThing dehydroabietadienal hydroxylase activity Catalysis of the reaction: dehydroabietadienal + NADPH + O2 <=> dehydroabietic acid + NADP + H2O. got7fsn_ti MetaCyc:RXN-8534 molecular_function owl:Class
GO:0047058 biolink:NamedThing vitamin-K-epoxide reductase (warfarin-insensitive) activity Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. got7fsn_ti vitamin K 2,3-epoxide reductase activity https://github.com/geneontology/go-ontology/issues/21412 Formerly EC:1.1.4.2. MetaCyc:1.1.4.2-RXN|EC:1.17.4.5|RHEA:21560 molecular_function owl:Class
GO:0006437 biolink:NamedThing tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0047360 biolink:NamedThing undecaprenyl-phosphate galactose phosphotransferase activity Catalysis of the reaction: all-trans-undecaprenyl phosphate + UDP-D-galactose = alpha-D-galactosyl-diphosphoundecaprenol + UMP. got7fsn_ti undecaprenyl phosphate galactosyl-1-phosphate transferase activity|poly(isoprenyl)phosphate galactosephosphatetransferase activity|poly(isoprenol)-phosphate galactose phosphotransferase activity|UDP-galactose:undecaprenyl-phosphate galactose phosphotransferase activity|poly(isoprenol)-phosphate galactosephosphotransferase activity RHEA:11652|KEGG_REACTION:R01535|EC:2.7.8.6|MetaCyc:2.7.8.6-RXN molecular_function owl:Class
GO:0102481 biolink:NamedThing 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity Catalysis of the reaction: 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O <=> 5-deoxy-D-glucuronate + H+. got7fsn_ti MetaCyc:RXN-14149|EC:3.7.1.22|RHEA:25836 molecular_function owl:Class
GO:0102493 biolink:NamedThing wogonin 7-O-glucosyltransferase activity Catalysis of the reaction: wogonin + UDP-alpha-D-glucose <=> wogonin 7-O-beta-D-glucoside + UDP + H+. got7fsn_ti MetaCyc:RXN-14239 molecular_function owl:Class
GO:0010288 biolink:NamedThing response to lead ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus. got7fsn_ti biological_process owl:Class
GO:0005168 biolink:NamedThing neurotrophin TRKA receptor binding Binding to a neurotrophin TRKA receptor. got7fsn_ti neurotrophin TRKA receptor ligand molecular_function owl:Class
GO:0070710 biolink:NamedThing RNA uridine deletion The modification of an RNA molecule by removal of a uridine nucleotide. got7fsn_ti RNA U deletion|RNA uridine excision mah 2009-06-08T05:12:43Z biological_process owl:Class
GO:0005607 biolink:NamedThing laminin-2 complex A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains. got7fsn_ti laminin-211 complex cellular_component owl:Class
GO:0006539 biolink:NamedThing glutamate catabolic process via 2-oxoglutarate The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate. got7fsn_ti glutamate catabolic process via alpha-ketoglutarate|glutamate catabolic process via alpha-oxoglutarate|glutamate catabolism via alpha-ketoglutarate|glutamate breakdown via 2-oxoglutarate|glutamate degradation via 2-oxoglutarate|glutamate catabolic process via 2-ketoglutarate|glutamate catabolism via alpha-oxoglutarate|glutamate catabolism via 2-ketoglutarate MetaCyc:P162-PWY biological_process owl:Class
GO:0002753 biolink:NamedThing cytoplasmic pattern recognition receptor signaling pathway Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. got7fsn_ti cytoplasmic PAMP receptor signaling pathway|cytoplasmic pathogen receptor signaling pathway|cytoplasmic PRR signaling pathway|cytoplasmic pattern recognition receptor signalling pathway https://github.com/geneontology/go-ontology/issues/18588 biological_process owl:Class
GO:0050928 biolink:NamedThing negative regulation of positive chemotaxis Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. got7fsn_ti inhibition of positive chemotaxis|down-regulation of positive chemotaxis|down regulation of positive chemotaxis|downregulation of positive chemotaxis biological_process owl:Class
GO:0034927 biolink:NamedThing pyrene 1,2-monooxygenase activity Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O. got7fsn_ti UM-BBD_reactionID:r0943 molecular_function owl:Class
GO:0006104 biolink:NamedThing succinyl-CoA metabolic process The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A. got7fsn_ti succinyl-CoA metabolism biological_process owl:Class
GO:0030737 biolink:NamedThing iodophenol O-methyltransferase activity Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+). got7fsn_ti S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN|EC:2.1.1.26|RHEA:14313|KEGG_REACTION:R03746 molecular_function owl:Class
GO:0050303 biolink:NamedThing lysine 6-dehydrogenase activity Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine. got7fsn_ti L-lysine epsilon-dehydrogenase activity|L-lysine:NAD+ 6-oxidoreductase (deaminating)|L-lysine 6-dehydrogenase activity|LysDH activity MetaCyc:LYSINE-6-DEHYDROGENASE-RXN|RHEA:12408|EC:1.4.1.18|MetaCyc:PWY-5314 molecular_function owl:Class
GO:0019710 biolink:NamedThing peptidyl-asparagine methylation The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine. got7fsn_ti GO:0018018 RESID:AA0311|RESID:AA0070 biological_process owl:Class
GO:0102062 biolink:NamedThing alpha-santalene synthase activity Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate <=> (+)-alpha-santalene + diphosphoric acid. got7fsn_ti RHEA:30463|EC:4.2.3.50|MetaCyc:RXN-10567 molecular_function owl:Class
GO:0047049 biolink:NamedThing (R)-2-hydroxy-fatty acid dehydrogenase activity Catalysis of the reaction: (R)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH. got7fsn_ti 2-hydroxy fatty acid oxidase|(R)-2-hydroxy-fatty-acid dehydrogenase activity|(R)-2-hydroxystearate:NAD+ oxidoreductase activity|D-2-hydroxy fatty acid dehydrogenase activity MetaCyc:1.1.1.98-RXN|RHEA:15949|EC:1.1.1.98|KEGG_REACTION:R03021 molecular_function owl:Class
GO:1900765 biolink:NamedThing emericellin catabolic process The chemical reactions and pathways resulting in the breakdown of emericellin. got7fsn_ti Variecoxanthone B catabolism|emericellin breakdown|Variecoxanthone B breakdown|emericellin degradation|Variecoxanthone B degradation|emericellin catabolism|Variecoxanthone B catabolic process di 2012-06-04T09:18:22Z biological_process owl:Class
GO:0008312 biolink:NamedThing 7S RNA binding Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). got7fsn_ti molecular_function owl:Class
GO:0102043 biolink:NamedThing isopentenyl phosphate kinase activity Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) <=> isopentenyl diphosphate(3-) + ADP(3-). got7fsn_ti MetaCyc:RXN-10068|EC:2.7.4.26|RHEA:33963 molecular_function owl:Class
GO:0047418 biolink:NamedThing phthalyl amidase activity Catalysis of the reaction: H2O + a phthalylamide = phthalate + substituted amine. got7fsn_ti phthalyl-amide amidohydrolase activity|o-phthalyl amidase activity EC:3.5.1.79|MetaCyc:3.5.1.79-RXN|RHEA:18297 molecular_function owl:Class
GO:0070635 biolink:NamedThing nicotinamide riboside hydrolase activity Catalysis of the reaction: nicotinamide riboside + H2O = nicotinamide + D-ribose. got7fsn_ti N-ribosylnicotinamide hydrolase activity|nicotinamide ribonucleoside hydrolase activity mah 2009-05-07T02:01:42Z MetaCyc:RXN-8441 molecular_function owl:Class
GO:0060101 biolink:NamedThing negative regulation of phagocytosis, engulfment Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis. got7fsn_ti biological_process owl:Class
GO:0050765 biolink:NamedThing negative regulation of phagocytosis Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis. got7fsn_ti inhibition of phagocytosis|down-regulation of phagocytosis|down regulation of phagocytosis|downregulation of phagocytosis biological_process owl:Class
GO:0061217 biolink:NamedThing regulation of mesonephros development Any process that modulates the rate, frequency or extent of mesonephros development. Mesonephros development is the process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. The mesonephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine. got7fsn_ti dph 2010-08-17T03:35:31Z biological_process owl:Class
GO:1990841 biolink:NamedThing promoter-specific chromatin binding Binding to a section of chromatin that is associated with gene promoter sequences of DNA. got7fsn_ti sl 2015-08-28T14:48:29Z molecular_function owl:Class
GO:0050254 biolink:NamedThing rhodopsin kinase activity Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin. got7fsn_ti GRK1|cone opsin kinase activity|ATP:rhodopsin phosphotransferase activity|rhodopsin kinase (phosphorylating) activity|G-protein-coupled receptor kinase 1 activity|GPCR kinase 1 activity|GRK7|opsin kinase activity|STK14|opsin kinase (phosphorylating) activity|RK MetaCyc:2.7.11.14-RXN|EC:2.7.11.14|RHEA:23356|Reactome:R-HSA-2581474 molecular_function owl:Class
GO:1900608 biolink:NamedThing tensidol B biosynthetic process The chemical reactions and pathways resulting in the formation of tensidol B. got7fsn_ti tensidol B synthesis|tensidol B biosynthesis|tensidol B formation|tensidol B anabolism di 2012-05-15T06:58:51Z biological_process owl:Class
GO:0004590 biolink:NamedThing orotidine-5'-phosphate decarboxylase activity Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP. got7fsn_ti UMP synthase activity|OMP-DC|orotidylic decarboxylase activity|ODCase activity|orotodylate decarboxylase activity|orotate monophosphate decarboxylase activity|orotidine-5'-monophosphate decarboxylase activity|orotidine-5'-phosphate carboxy-lyase (UMP-forming)|orotic decarboxylase activity|orotidine-5'-phosphate carboxy-lyase activity|OMP decarboxylase activity|OMPdcase activity|uridine 5'-monophosphate synthase activity|orotidine monophosphate decarboxylase activity|orotidine phosphate decarboxylase activity|orotidine 5'-phosphate decarboxylase activity|orotidylic acid decarboxylase activity|orotate decarboxylase activity EC:4.1.1.23|MetaCyc:OROTPDECARB-RXN|Reactome:R-HSA-73564|KEGG_REACTION:R00965|RHEA:11596 molecular_function owl:Class
GO:0036514 biolink:NamedThing dopaminergic neuron axon guidance The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti mdDA axon guidance|DA axon guidance|dopaminergic axon guidance bf 2015-12-17T11:14:20Z biological_process owl:Class
GO:0098669 biolink:NamedThing superinfection exclusion The process by which a preexisting viral infection prevents a secondary infection with the same or a closely related virus. Typically some aspect of viral entry is inhibited, but post entry mechanisms have also been documented. got7fsn_ti dos 2017-01-16T17:25:21Z VZ:3971 biological_process owl:Class
GO:0046988 biolink:NamedThing asioloorosomucoid beta-1,3-glucuronosyltransferase activity Catalysis of the transfer, in a beta 1,3 linkage, of D-glucuronic acid (GlcUA) from UDP-GlcUA to asioloorosomucoid. got7fsn_ti molecular_function owl:Class
GO:0052822 biolink:NamedThing DNA-3-methylguanine glycosylase activity Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site. got7fsn_ti alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)|3-methylguanine DNA glycosylase I|deoxyribonucleate 3-methylguanine glycosidase I|DNA glycosidase I activity ai 2011-10-28T02:28:19Z MetaCyc:3.2.2.21-RXN|EC:3.2.2.21 molecular_function owl:Class
GO:0010267 biolink:NamedThing production of ta-siRNAs involved in RNA interference Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs. got7fsn_ti RNA interference, production of ta-siRNAs biological_process owl:Class
GO:0047034 biolink:NamedThing 15-hydroxyicosatetraenoate dehydrogenase activity Catalysis of the reaction: NAD(P)+ + (15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate = NAD(P)H + H+ + 15-oxo-5,8,11-cis-13-trans-icosatetraenoate. got7fsn_ti 15-hydroxyeicosatetraenoate dehydrogenase activity|(15S)-15-hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NAD(P)+ 15-oxidoreductase activity MetaCyc:1.1.1.232-RXN|EC:1.1.1.232|Reactome:R-HSA-2161789 molecular_function owl:Class
GO:0062139 biolink:NamedThing camera-type eye photoreceptor cell development The process whose specific outcome is the progression of a light-responsive receptor in a camera-type eye over time, from its formation to the mature structure. got7fsn_ti dph 2019-08-06T12:40:36Z biological_process owl:Class
GO:0060081 biolink:NamedThing membrane hyperpolarization The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential. got7fsn_ti biological_process owl:Class
GO:0034921 biolink:NamedThing cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r0935 molecular_function owl:Class
GO:0070218 biolink:NamedThing sulfide ion homeostasis Any process involved in the maintenance of an internal steady state of sulfide ions within an organism or cell. got7fsn_ti sulphide ion homeostasis|sulphide generation|sulfide homeostasis|sulfide generation|sulphide homeostasis|sulfide production|sulphide production biological_process owl:Class
GO:0050229 biolink:NamedThing pterocarpin synthase activity Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH. got7fsn_ti medicarpin:NADP+ 2'-oxidoreductase activity|pterocarpan synthase activity EC:1.1.1.246|MetaCyc:PTEROCARPIN-SYNTHASE-RXN|RHEA:13533 molecular_function owl:Class
GO:0050439 biolink:NamedThing 2-hydroxy-3-oxoadipate synthase activity Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2). got7fsn_ti oxoglutarate:glyoxylate carboligase activity|alpha-ketoglutaric-glyoxylic carboligase activity|oxoglutarate: glyoxylate carboligase activity|2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating) activity|2-hydroxy-3-oxoadipate synthetase activity|2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating) RHEA:14341|EC:2.2.1.5|KEGG_REACTION:R00474|MetaCyc:2-HYDROXY-3-OXOADIPATE-SYNTHASE-RXN molecular_function owl:Class
GO:0072631 biolink:NamedThing interleukin-29 production The appearance of interleukin-29 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IL29 production|IL-29 production|interferon lambda 1 production|interleukin-29 secretion Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072632 biological_process owl:Class
GO:0034874 biolink:NamedThing thioacetamide S-oxide S-oxygenase activity Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O. got7fsn_ti UM-BBD_reactionID:r1313 molecular_function owl:Class
GO:0061734 biolink:NamedThing parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization A positive regulation of the macromitophagy pathway that is triggered by mitochondrial depolarization and requires the function of a parkin-family molecule. got7fsn_ti Park2-mediated stimulation of mitophagy in response to mitochondrial depolarization|PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization dph 2015-09-14T13:48:57Z biological_process owl:Class
GO:0008226 biolink:NamedThing tyramine receptor activity Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine. got7fsn_ti molecular_function owl:Class
GO:0099070 biolink:NamedThing static microtubule bundle A microtubule bundle that has a constant length, and in which microtubule sliding does not take place. got7fsn_ti quiescent cell microtubule bundle|quiescent cell MT bundle|Q-MT bundle In fission yeast, quiescent cells contain only static microtubule bundles. cellular_component owl:Class
GO:0010715 biolink:NamedThing regulation of extracellular matrix disassembly Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix. got7fsn_ti regulation of extracellular matrix breakdown|regulation of extracellular matrix degradation biological_process owl:Class
GO:1990155 biolink:NamedThing Dsc E3 ubiquitin ligase complex assembly The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane. got7fsn_ti Dsc complex assembly mah 2013-08-01T14:19:19Z biological_process owl:Class
GO:0032444 biolink:NamedThing activin responsive factor complex A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor. got7fsn_ti ARF complex Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor). cellular_component owl:Class
GO:0106105 biolink:NamedThing Ala-tRNA(Thr) hydrolase activity Catalysis of the hydrolysis of misacylated ala-tRNA(thr). got7fsn_ti L-alanyl-tRNA(Thr) deacylase hjd 2018-03-14T22:03:29Z molecular_function owl:Class
GO:0019158 biolink:NamedThing mannokinase activity Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate. got7fsn_ti D-fructose (D-mannose) kinase activity|ATP:D-mannose 6-phosphotransferase activity|mannokinase (phosphorylating) MetaCyc:MANNKIN-RXN|RHEA:11028|EC:2.7.1.7 molecular_function owl:Class
GO:0050419 biolink:NamedThing hydroxymandelonitrile lyase activity Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate. got7fsn_ti (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase activity|(S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming)|hydroxynitrile lyase activity|sorghum hydroxynitrile lyase activity EC:4.1.2.11|MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN|RHEA:15977 molecular_function owl:Class
GO:0007580 biolink:NamedThing extrachromosomal circular DNA accumulation involved in cell aging Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication. got7fsn_ti extrachromosomal circular DNA accumulation during cell ageing|extrachromosomal circular DNA accumulation during cell aging Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. biological_process owl:Class
GO:0018628 biolink:NamedThing terephthalate 1,2-dioxygenase activity Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+). got7fsn_ti benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)|1,4-dicarboxybenzoate 1,2-dioxygenase activity|benzene-1,4-dicarboxylate 1,2-dioxygenase activity RHEA:10312|MetaCyc:1.14.12.15-RXN|UM-BBD_reactionID:r0150|KEGG_REACTION:R05148|EC:1.14.12.15 molecular_function owl:Class
GO:0036517 biolink:NamedThing chemoattraction of serotonergic neuron axon The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal. got7fsn_ti chemoattraction of serotonergic axon|chemoattraction of 5-HT axon bf 2015-12-17T11:26:03Z biological_process owl:Class
GO:0004668 biolink:NamedThing protein-arginine deiminase activity Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3. This reaction is calcium-dependent. got7fsn_ti protein-L-arginine iminohydrolase activity|peptidylarginine deiminase activity https://github.com/geneontology/go-ontology/issues/18666 Reactome:R-HSA-3247569|EC:3.5.3.15|MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN|RHEA:18089|Reactome:R-HSA-1183128 molecular_function owl:Class
GO:0035733 biolink:NamedThing hepatic stellate cell activation A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor. got7fsn_ti bf 2011-03-11T10:04:12Z biological_process owl:Class
GO:0050490 biolink:NamedThing 1,4-lactonase activity Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid. got7fsn_ti 1,4-lactone hydroxyacylhydrolase activity|gamma-lactonase activity MetaCyc:14-LACTONASE-RXN|EC:3.1.1.25|RHEA:12745 molecular_function owl:Class
GO:0002273 biolink:NamedThing plasmacytoid dendritic cell differentiation The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell. got7fsn_ti biological_process owl:Class
GO:0035750 biolink:NamedThing protein localization to myelin sheath abaxonal region Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon. got7fsn_ti protein localisation to myelin sheath abaxonal region bf 2011-03-23T10:20:06Z biological_process owl:Class
GO:0002358 biolink:NamedThing B cell homeostatic proliferation The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus. got7fsn_ti B-lymphocyte homeostatic proliferation|B-cell homeostatic proliferation|B lymphocyte homeostatic proliferation biological_process owl:Class
GO:0044393 biolink:NamedThing microspike A dynamic, actin-rich projection extending from the surface of a migrating animal cell. got7fsn_ti Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. See also 'filopodium ; GO:0030175'. bf 2011-12-06T01:31:16Z cellular_component owl:Class
GO:0070411 biolink:NamedThing I-SMAD binding Binding to an inhibitory SMAD signaling protein. got7fsn_ti molecular_function owl:Class
GO:0035341 biolink:NamedThing regulation of inosine transport Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti regulation of hypoxanthine riboside transport bf 2010-03-04T10:03:51Z biological_process owl:Class
GO:0003271 biolink:NamedThing smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. got7fsn_ti hh signaling pathway involved in regulation of second heart field cardioblast proliferation|smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation|smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation|smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation|hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation dph 2009-10-15T02:48:32Z biological_process owl:Class
GO:0061311 biolink:NamedThing cell surface receptor signaling pathway involved in heart development Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time. got7fsn_ti cell surface receptor linked signalling pathway involved in heart development|cell surface receptor linked signaling pathway involved in heart development dph 2010-09-23T09:18:32Z biological_process owl:Class
GO:0031419 biolink:NamedThing cobalamin binding Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. got7fsn_ti vitamin B12 binding molecular_function owl:Class
GO:1990532 biolink:NamedThing stress response to nickel ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus. got7fsn_ti stress response to nickel|response to nickel ion stress|response to nickel toxicity kmv 2014-11-07T18:35:31Z biological_process owl:Class
GO:0002153 biolink:NamedThing steroid receptor RNA activator RNA binding Binding to a steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding. got7fsn_ti SRA binding Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken). hjd 2009-11-16T02:18:55Z molecular_function owl:Class
GO:0016807 biolink:NamedThing cysteine-type carboxypeptidase activity Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19681 EC:3.4.18.-|MetaCyc:3.4.18.1-RXN molecular_function owl:Class
GO:0034016 biolink:NamedThing polyenoic fatty acid isomerase activity Catalysis of the reaction: all-cis-icosa-5,8,11,14,17-pentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate. got7fsn_ti (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity|(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate delta8,11-delta7,9-isomerase (trans-double-bond-forming) activity|(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate delta8,11-delta7,8-isomerase activity|PFI|eicosapentaenoate cis-delta5,8,11,14,17-eicosapentaenoate cis-delta5-trans-delta7,9-cis-delta14,17 isomerase activity KEGG_REACTION:R06502|MetaCyc:5.3.3.13-RXN|RHEA:14889|EC:5.3.3.13 molecular_function owl:Class
GO:0098632 biolink:NamedThing cell-cell adhesion mediator activity The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell. got7fsn_ti cell-cell adhesion molecule|protein binding involved in cell-cell adhesion molecular_function owl:Class
GO:0048689 biolink:NamedThing formation of growth cone in injured axon The formation of a growth cone in an injured axon. got7fsn_ti biological_process owl:Class
GO:0018618 biolink:NamedThing anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3. got7fsn_ti anthranilate dioxygenase activity|anthranilic acid hydroxylase activity|AntA|anthranilic hydroxylase activity|AntC|anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)|AntB|anthranilate 1,2-dioxygenase|anthranilate hydroxylase activity|anthranilate dioxygenase reductase MetaCyc:1.14.12.1-RXN|UM-BBD_reactionID:r0577|EC:1.14.12.1 molecular_function owl:Class
GO:0031071 biolink:NamedThing cysteine desulfurase activity Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. got7fsn_ti SufS|NIFS|cysteine desulfurylase activity|L-cysteine:enzyme cysteine sulfurtransferase activity|IscS Reactome:R-HSA-947514|EC:2.8.1.7|RHEA:43892|Reactome:R-HSA-1362408 molecular_function owl:Class
GO:0050288 biolink:NamedThing sorbose dehydrogenase activity Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2). got7fsn_ti L-sorbose:(acceptor) 5-oxidoreductase activity|L-sorbose:acceptor 5-oxidoreductase activity EC:1.1.99.12|RHEA:14713|MetaCyc:SORBOSE-DEHYDROGENASE-RXN|KEGG_REACTION:R01696 molecular_function owl:Class
GO:0018820 biolink:NamedThing cyanamide hydratase activity Catalysis of the reaction: urea = cyanamide + H(2)O. got7fsn_ti urea hydro-lyase (cyanamide-forming)|urea hydro-lyase activity MetaCyc:CYANAMIDE-HYDRATASE-RXN|EC:4.2.1.69|UM-BBD_reactionID:r0668|KEGG_REACTION:R00778|RHEA:23056 molecular_function owl:Class
GO:0008959 biolink:NamedThing phosphate acetyltransferase activity Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate. got7fsn_ti phosphoacylase activity|PTA|phosphotransacetylase activity|acetyl-CoA:phosphate acetyltransferase activity RHEA:19521|EC:2.3.1.8|MetaCyc:PHOSACETYLTRANS-RXN molecular_function owl:Class
GO:0004945 biolink:NamedThing angiotensin type II receptor activity An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms. got7fsn_ti molecular_function owl:Class
GO:0019755 biolink:NamedThing one-carbon compound transport The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti one carbon compound transport biological_process owl:Class
GO:0005683 biolink:NamedThing U7 snRNP A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs. got7fsn_ti snRNP U7 cellular_component owl:Class
GO:0043184 biolink:NamedThing vascular endothelial growth factor receptor 2 binding Binding to a vascular endothelial growth factor receptor 2. got7fsn_ti VEGF receptor 2 binding|VEGFR 2 binding|KDR binding|kinase domain region binding|Flk-1 binding molecular_function owl:Class
GO:0044299 biolink:NamedThing C-fiber The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated. got7fsn_ti C-fibre jl 2010-02-05T11:14:51Z NIF_Subcellular:nlx_subcell_20090210 cellular_component owl:Class
GO:0098914 biolink:NamedThing membrane repolarization during atrial cardiac muscle cell action potential The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. got7fsn_ti electrocardiogram QRS complex|atrial repolarization biological_process owl:Class
GO:0030797 biolink:NamedThing 24-methylenesterol C-methyltransferase activity Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+). got7fsn_ti 24-methylenelophenol C-241-methyltransferase activity|24-methylenelophenol C-24(1)-methyltransferase activity|SMT2|S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity|SMT(2) activity RHEA:21044|KEGG_REACTION:R05776|EC:2.1.1.143|MetaCyc:2.1.1.143-RXN molecular_function owl:Class
GO:0070766 biolink:NamedThing endobrevin-synaptobrevin 2-alpha-SNAP-NSF-syntaxin-4 complex A SNARE complex that contains endobrevin (VAMP8), synaptobrevin 2 (VAMP2), alpha-SNAP, NSF, and syntaxin 4 (or orthologs thereof). got7fsn_ti Stx4-Napa-Vamp3-Nsf-Vamp2 complex|SNARE complex (Stx4, Napa, Vamp3, Nsf, Vamp2) mah 2009-06-29T04:41:55Z cellular_component owl:Class
GO:0036082 biolink:NamedThing extracellular phenylacetaldehyde-gated ion channel activity Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts. got7fsn_ti ionotropic phenylacetaldehyde receptor activity bf 2011-12-20T04:49:31Z molecular_function owl:Class
GO:0043705 biolink:NamedThing cyanophycin metabolic process The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups. got7fsn_ti cyanophycin metabolism|multi-L-arginyl-poly(L-aspartic acid) metabolism biological_process owl:Class
GO:0035342 biolink:NamedThing positive regulation of inosine transport Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti positive regulation of hypoxanthine riboside transport bf 2010-03-04T10:05:03Z biological_process owl:Class
GO:0050232 biolink:NamedThing putrescine oxidase activity Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2. got7fsn_ti putrescine:oxygen oxidoreductase (deaminating) EC:1.4.3.10|MetaCyc:PUTRESCINE-OXIDASE-RXN|RHEA:18273 molecular_function owl:Class
GO:0009386 biolink:NamedThing translational attenuation Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation. got7fsn_ti biological_process owl:Class
GO:0047454 biolink:NamedThing phaseollidin hydratase activity Catalysis of the reaction: phaseollidin hydrate = H(2)O + phaseollidin. got7fsn_ti phaseollidin-hydrate hydro-lyase activity|phaseollidin-hydrate hydro-lyase (phaseollidin-forming) KEGG_REACTION:R04728|MetaCyc:4.2.1.97-RXN|RHEA:19769|EC:4.2.1.97 molecular_function owl:Class
GO:1902159 biolink:NamedThing regulation of cyclic nucleotide-gated ion channel activity Any process that modulates the frequency, rate or extent of cyclic nucleotide-gated ion channel activity. got7fsn_ti regulation of cyclic nucleotide-activated ion channel activity|regulation of cyclic nucleotide gated ion channel activity|regulation of cyclic nucleotide activated ion channel activity sl 2013-05-21T19:24:30Z biological_process owl:Class
GO:0050249 biolink:NamedThing Renilla-luciferin sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H(+) + luciferyl sulfate. got7fsn_ti luciferin sulfotransferase activity|luciferin sulfokinase activity|Renilla-luciferin sulphotransferase activity|luciferin sulfokinase (3'-phosphoadenylyl sulfate:luciferin sulfotransferase)|3'-phosphoadenylyl-sulfate:Renilla luciferin sulfotransferase activity EC:2.8.2.10|RHEA:20481|MetaCyc:RENILLA-LUCIFERIN-SULFOTRANSFERASE-RXN|KEGG_REACTION:R03138 molecular_function owl:Class
GO:0047675 biolink:NamedThing arabinonate dehydratase activity Catalysis of the reaction: D-arabinonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O. got7fsn_ti D-arabinonate hydro-lyase activity|D-arabinonate hydro-lyase (2-dehydro-3-deoxy-D-arabinonate-forming) EC:4.2.1.5|MetaCyc:ARABINONATE-DEHYDRATASE-RXN|RHEA:21836|KEGG_REACTION:R03032 molecular_function owl:Class
GO:0106306 biolink:NamedThing protein serine phosphatase activity Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate. got7fsn_ti hjd 2020-09-09T19:36:32Z EC:3.1.3.16|RHEA:20629 molecular_function owl:Class
GO:0033421 biolink:NamedThing CCU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CCU codon. got7fsn_ti proline tRNA|CCT codon-amino acid adaptor activity Note that in the standard genetic code, CCT codes for proline. molecular_function owl:Class
GO:0003846 biolink:NamedThing 2-acylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. got7fsn_ti acylglycerol palmitoyltransferase activity|acyl coenzyme A-monoglyceride acyltransferase activity|monoglyceride acyltransferase activity|acyl-CoA:2-acylglycerol O-acyltransferase activity|monoacylglycerol acyltransferase activity Reactome:R-HSA-5696448|MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN|Reactome:R-HSA-6800334|RHEA:16741|EC:2.3.1.22 molecular_function owl:Class
GO:0018937 biolink:NamedThing nitroglycerin metabolic process The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates. got7fsn_ti nitroglycerin metabolism|NG metabolic process|NG metabolism MetaCyc:P201-PWY|UM-BBD_pathwayID:ng biological_process owl:Class
GO:0052914 biolink:NamedThing 16S rRNA (guanine(1207)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine. got7fsn_ti M(2)G1207 methyltransferase activity RHEA:42736|MetaCyc:RXN-11576|EC:2.1.1.172|KEGG_REACTION:R07234 molecular_function owl:Class
GO:0047835 biolink:NamedThing D-tryptophan N-acetyltransferase activity Catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H(+). got7fsn_ti D-tryptophan acetyltransferase activity|acetyl-CoA:D-tryptophan N-acetyltransferase activity|acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity EC:2.3.1.34|RHEA:10060|KEGG_REACTION:R02481|MetaCyc:D-TRYPTOPHAN-N-ACETYLTRANSFERASE-RXN molecular_function owl:Class
GO:0018041 biolink:NamedThing C-terminal peptidyl-glycine amidation The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein. got7fsn_ti RESID:AA0088 biological_process owl:Class
GO:0043782 biolink:NamedThing cobalt-precorrin-3 C17-methyltransferase activity Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine. got7fsn_ti cobalt-precorrin-3 methylase|cobalt-precorrin-3B C17-methyltransferase activity|cobalt-precorrin-3 methyltransferase|cobalt-precorrin 3 C17-methyltransferase activity RHEA:26273|MetaCyc:RXN-8761 molecular_function owl:Class
GO:0070912 biolink:NamedThing Ddb1-Ckn1 complex A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases. got7fsn_ti mah 2009-09-09T03:41:04Z cellular_component owl:Class
GO:0036149 biolink:NamedThing phosphatidylinositol acyl-chain remodeling Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains. got7fsn_ti bf 2012-03-14T01:27:02Z biological_process owl:Class
GO:0002435 biolink:NamedThing immune complex clearance by erythrocytes The process of immune complex clearance by erythrocytes. The process often starts with binding of complement receptor 1 (CR1) on the surface of erythrocytes to a complement coated immune complex. The complex bound to erythrocyte CR1 is then transported to the liver or spleen where it is presented to phagocytes. The process ends when the complex is removed from CR1, allowing the erythrocyte to return to general circulation. got7fsn_ti immune complex clearance by RBCs|immune complex clearance by red blood cells https://github.com/geneontology/go-ontology/issues/19884 Wikipedia:Immune_complex biological_process owl:Class
GO:0043337 biolink:NamedThing CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol. got7fsn_ti cardiolipin synthetase|cardiolipin synthase Reactome:R-HSA-1483063|RHEA:32931|MetaCyc:RXN-8141 molecular_function owl:Class
GO:0097453 biolink:NamedThing mesaxon Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide. got7fsn_ti mesaxon of Schwann cell pr 2012-12-19T12:59:13Z NIF_Subcellular:sao2127666702 cellular_component owl:Class
GO:0035179 biolink:NamedThing larval turning behavior Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source. got7fsn_ti larval turning behaviour biological_process owl:Class
GO:0052726 biolink:NamedThing inositol-1,3,4-trisphosphate 5-kinase activity Catalysis of the reaction: 1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+). got7fsn_ti inositol 1,3,4-trisphosphate 5-kinase activity|IP3 5-kinase activity|1D-myo-inositol-trisphosphate 5-kinase activity|ins(1,3,4)P(3) 5-kinase activity|ATP:1D-myo-inositol-1,3,4-trisphosphate 5-phosphotransferase activity|Ins(1,3,4)P3 5-kinase activity|inositol-trisphosphate 5-kinase activity ai 2011-08-16T12:43:11Z EC:2.7.1.159|Reactome:R-HSA-1855172|KEGG_REACTION:R03428|Reactome:R-HSA-994140|MetaCyc:2.7.1.139-RXN|RHEA:13253 molecular_function owl:Class
GO:0033770 biolink:NamedThing 2-hydroxyisoflavanone synthase activity Catalysis of the reaction: apigenin + 2 NADPH + 2 H+ + O2 = 2-hydroxy-2,3-dihydrogenistein + 2 NADP+ + H2O. got7fsn_ti 2-HIS|apigenin,NADPH:oxygen oxidoreductase (isoflavanone-forming) activity EC:1.14.13.86|RHEA:14897|MetaCyc:RXN-7750 molecular_function owl:Class
GO:0003075 biolink:NamedThing renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system. got7fsn_ti renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system biological_process owl:Class
GO:0102276 biolink:NamedThing 2-oxoglutarate oxygenase/decarboxylase (ethylene-forming) activity Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ <=> ethene + 3 carbon dioxide + H2O. got7fsn_ti RHEA:31523|EC:1.13.12.19|MetaCyc:RXN-12538 molecular_function owl:Class
GO:0043707 biolink:NamedThing cell adhesion involved in single-species biofilm formation in or on host organism The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a host species. got7fsn_ti cell adhesion during single-species biofilm formation in or on host organism biological_process owl:Class
GO:0018893 biolink:NamedThing dibenzofuran metabolic process The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals. got7fsn_ti dibenzofuran metabolism UM-BBD_pathwayID:dbf biological_process owl:Class
GO:0050149 biolink:NamedThing o-aminophenol oxidase activity Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O. got7fsn_ti GriF|2-aminophenol:O2 oxidoreductase activity|o-aminophenol:O2 oxidoreductase activity|2-aminophenol:oxygen oxidoreductase activity|isophenoxazine synthase activity MetaCyc:O-AMINOPHENOL-OXIDASE-RXN|EC:1.10.3.4|RHEA:40963 molecular_function owl:Class
GO:0033961 biolink:NamedThing cis-stilbene-oxide hydrolase activity Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol. got7fsn_ti aryl epoxide hydrase activity|benzo(a)pyrene-4,5-epoxide hydratase activity|microsomal epoxide hydratase activity|benzo[a]pyrene-4,5-oxide hydratase activity|epoxide hydrase activity|mEH|microsomal epoxide hydrase activity|microsomal epoxide hydrolase activity|epoxide hydratase activity|cis-epoxide hydrolase activity|arene-oxide hydratase activity MetaCyc:3.3.2.9-RXN|Reactome:R-HSA-5694077|RHEA:23900|EC:3.3.2.9 molecular_function owl:Class
GO:0102906 biolink:NamedThing 7-epi-alpha-selinene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> (-)-7-epi-alpha-selinene + diphosphoric acid. got7fsn_ti RHEA:30383|EC:4.2.3.86|MetaCyc:RXN-8609 molecular_function owl:Class
GO:0036321 biolink:NamedThing ghrelin secretion The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone. got7fsn_ti pancreatic ghrelin secretion bf 2012-09-04T14:16:43Z biological_process owl:Class
GO:0033796 biolink:NamedThing sulfur reductase activity Catalysis of the reduction of elemental sulfur or polysulfide to hydrogen sulfide. got7fsn_ti sulphur reductase activity|(donor):sulfur oxidoreductase activity MetaCyc:RXN-8269|MetaCyc:1.97.1.3-RXN|EC:1.12.98.4|RHEA:35591 molecular_function owl:Class
GO:0008108 biolink:NamedThing UDP-glucose:hexose-1-phosphate uridylyltransferase activity Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose. got7fsn_ti uridyl transferase activity|uridyltransferase activity|uridylyl removing enzyme activity|UDP-glucose-hexose-1-phosphate uridylyltransferase activity|Gal-1-P uridylyltransferase activity|galactose-1-phosphate uridylyltransferase activity|UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity|UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity|hexose-1-phosphate uridylyltransferase activity|UDPglucose-hexose-1-phosphate uridylyltransferase activity|hexose 1-phosphate uridyltransferase activity MetaCyc:GALACTURIDYLYLTRANS-RXN|KEGG_REACTION:R00955|Reactome:R-HSA-70361|EC:2.7.7.12|Reactome:R-HSA-5610038|RHEA:13989 molecular_function owl:Class
GO:0008208 biolink:NamedThing C21-steroid hormone catabolic process The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. got7fsn_ti C21-steroid hormone degradation|C21-steroid hormone catabolism|C21-steroid hormone breakdown biological_process owl:Class
GO:0045303 biolink:NamedThing diaminobutyrate-2-oxoglutarate transaminase activity Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate. got7fsn_ti 2,4-diaminobutyrate 4-aminotransferase activity|diaminibutyric acid aminotransferase activity|L-2,4-diaminobutyrate:2-oxoglutarate 4-aminotransferase activity|L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase activity|EctB|L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase activity|diaminobutyrate transaminase activity|DAB aminotransferase activity|DABA aminotransferase activity|diaminobutyrate--2-oxoglutarate aminotransferase activity RHEA:11160|KEGG_REACTION:R06977|MetaCyc:R101-RXN|EC:2.6.1.76 molecular_function owl:Class
GO:0006924 biolink:NamedThing activation-induced cell death of T cells A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors. got7fsn_ti activation-induced cell death of T-cells|antigen-driven apoptosis|activation-induced cell death of T-lymphocytes|activation-induced cell death of T lymphocytes|AICD|activated T cell apoptosis biological_process owl:Class
GO:0052913 biolink:NamedThing 16S rRNA (guanine(966)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine. got7fsn_ti EC:2.1.1.171|MetaCyc:RXN0-6515|KEGG_REACTION:R07234|RHEA:23548 molecular_function owl:Class
GO:0102639 biolink:NamedThing paspalicine synthase activity Catalysis of the reaction: 13-desoxypaxilline + NADPH + O2 + H+ <=> paspalicine + NADP + 2 H2O. got7fsn_ti MetaCyc:RXN-15737 molecular_function owl:Class
GO:0043780 biolink:NamedThing cobalt-precorrin-5B C1-methyltransferase activity Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A. got7fsn_ti cobalt-precorrin 5B C1-methyltransferase activity MetaCyc:RXN-8764|RHEA:26285 molecular_function owl:Class
GO:0098864 biolink:NamedThing modification by symbiont of host tight cell-cell junction The process in which a symbiont organism effects a change in the structure or function of its host tight junction, a cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other. got7fsn_ti biological_process owl:Class
GO:1990487 biolink:NamedThing anaerobic lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units. got7fsn_ti anaerobic lignin degradation tt 2014-09-20T17:35:09Z biological_process owl:Class
GO:0046274 biolink:NamedThing lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. got7fsn_ti lignin degradation|lignin catabolism|lignin breakdown biological_process owl:Class
GO:0009753 biolink:NamedThing response to jasmonic acid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus. got7fsn_ti response to jasmonic acid stimulus biological_process owl:Class
GO:0018527 biolink:NamedThing cyclohexylamine oxidase activity Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide. got7fsn_ti cyclohexylamine:oxygen oxidoreductase (deaminating) MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN|UM-BBD_reactionID:r0754|EC:1.4.3.12|RHEA:18433 molecular_function owl:Class
GO:0018517 biolink:NamedThing phthalate 4,5-cis-dihydrodiol dehydrogenase activity Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH. got7fsn_ti cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity MetaCyc:1.3.1.64-RXN|EC:1.3.1.64|RHEA:13837|KEGG_REACTION:R05275|UM-BBD_reactionID:r0142 molecular_function owl:Class
GO:0016656 biolink:NamedThing monodehydroascorbate reductase (NADH) activity Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate. got7fsn_ti NADH:ascorbate radical oxidoreductase activity|NADH-semidehydroascorbate oxidoreductase activity|MDHA|SDA reductase activity|ascorbic free radical reductase activity|monodehydroascorbate reductase activity|NADH:semidehydroascorbic acid oxidoreductase activity|AFR|MDAsA reductase (NADPH)|semidehydroascorbate reductase activity|AFR-reductase activity|ascorbate free-radical reductase activity|ascorbate free radical reductase activity|NADH:AFR oxidoreductase activity|NADH:monodehydroascorbate oxidoreductase activity RHEA:14581|MetaCyc:1.6.5.4-RXN|EC:1.6.5.4 molecular_function owl:Class
GO:0004573 biolink:NamedThing mannosyl-oligosaccharide glucosidase activity Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). got7fsn_ti processing A-glucosidase I activity|Glc3Man9NAc2 oligosaccharide glucosidase activity|trimming glucosidase I|mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity|mannosyl-oligosaccharide glucohydrolase activity Reactome:R-HSA-532678|Reactome:R-HSA-4793947|RHEA:55988|EC:3.2.1.106|Reactome:R-HSA-9694364|MetaCyc:3.2.1.106-RXN molecular_function owl:Class
GO:1990244 biolink:NamedThing histone kinase activity (H2A-T120 specific) Catalysis of the transfer of a phosphate group to the threonine-120 residue of histone H2A. got7fsn_ti histone threonine kinase activity (H2A-T120 specific) sp 2013-12-04T06:38:32Z molecular_function owl:Class
GO:0033250 biolink:NamedThing penicillinase activity Catalysis of the reaction: a penicillin + H2O = a substituted beta-amino acid derivative of the penicillin. got7fsn_ti MetaCyc:BETA-LACTAMASE-RXN molecular_function owl:Class
GO:0006432 biolink:NamedThing phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. got7fsn_ti biological_process owl:Class
GO:0007434 biolink:NamedThing adult salivary gland boundary specification Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland. got7fsn_ti larval salivary gland determination biological_process owl:Class
GO:0044652 biolink:NamedThing adhesion of symbiont to host endothelial cell The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly. got7fsn_ti jl 2012-07-12T12:49:07Z biological_process owl:Class
GO:0001566 biolink:NamedThing non-kinase phorbol ester receptor activity Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity. got7fsn_ti molecular_function owl:Class
GO:0061184 biolink:NamedThing positive regulation of dermatome development Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin. got7fsn_ti dph 2010-07-14T08:42:03Z biological_process owl:Class
GO:0032882 biolink:NamedThing regulation of chitin metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin. got7fsn_ti regulation of chitin metabolism biological_process owl:Class
GO:0018127 biolink:NamedThing NAD(P)-serine ADP-ribosyltransferase activity Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine. got7fsn_ti molecular_function owl:Class
GO:0033814 biolink:NamedThing propanoyl-CoA C-acyltransferase activity Catalysis of the reaction: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestanoyl-CoA. got7fsn_ti PTE-2|SCP-X|sterol carrier protein-chi|peroxisomal thiolase 2 activity|sterol carrier protein-X|SCPchi|3alpha,7alpha,12alpha-trihydroxy-5beta-cholanoyl-CoA:propanoyl-CoA C-acyltransferase activity EC:2.3.1.176|MetaCyc:2.3.1.176-RXN|RHEA:16865 molecular_function owl:Class
GO:0015381 biolink:NamedThing high-affinity sulfate transmembrane transporter activity Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations. got7fsn_ti high affinity sulphate permease activity|high affinity sulfate permease activity|high affinity sulfate transmembrane transporter activity molecular_function owl:Class
GO:0008271 biolink:NamedThing secondary active sulfate transmembrane transporter activity Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti sulphate porter activity|sulfate porter activity|secondary active sulphate transmembrane transporter activity molecular_function owl:Class
GO:0033715 biolink:NamedThing nucleoside oxidase activity Catalysis of the reactions: inosine + O2 = 9-riburonosylhypoxanthine + 2 H2O; (1a) 2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O, and (1b) 2 5'-dehydroinosine + O2 = 2 9-riburonosylhypoxanthine + 2 H2O. got7fsn_ti nucleoside:oxygen 5'-oxidoreductase activity EC:1.1.3.28|MetaCyc:NUCLEOSIDE-OXIDASE-RXN|RHEA:28651 molecular_function owl:Class
GO:0043904 biolink:NamedThing isochorismate pyruvate lyase activity Catalysis of the reaction: isochorismate = salicylate + pyruvate. got7fsn_ti IPL|isochorismate-pyruvate lyase activity MetaCyc:RXN-1981|RHEA:27874|EC:4.2.99.21 molecular_function owl:Class
GO:0102679 biolink:NamedThing (5alpha)-campestan-3-one hydroxylase activity Catalysis of the reaction: H+ + (5alpha)-campestan-3-one + O2 + NADPH <=> (5alpha,22S,24R)-22-hydroxyergostan-3-one + H2O + NADP. got7fsn_ti MetaCyc:RXN-4230 molecular_function owl:Class
GO:0019672 biolink:NamedThing ethanol-acetate fermentation to butyrate and caproate The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP. got7fsn_ti biological_process owl:Class
GO:0050899 biolink:NamedThing nitrile catabolic process The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom. got7fsn_ti nitrile catabolism|nitrile breakdown|nitrile degradation biological_process owl:Class
GO:0047426 biolink:NamedThing ricinine nitrilase activity Catalysis of the reaction: H2O + ricinine = NH3 + 3-carboxy-4-methoxy-N-methyl-2-pyridone. got7fsn_ti ricinine aminohydrolase activity RHEA:22704|EC:3.5.5.2|MetaCyc:3.5.5.2-RXN molecular_function owl:Class
GO:0018524 biolink:NamedThing acetophenone carboxylase activity Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate. got7fsn_ti GO:0018797 EC:6.4.1.-|UM-BBD_reactionID:r0033 molecular_function owl:Class
GO:0002467 biolink:NamedThing germinal center formation The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation. got7fsn_ti biological_process owl:Class
GO:0031770 biolink:NamedThing growth hormone-releasing hormone receptor binding Binding to a growth hormone-releasing hormone receptor. got7fsn_ti growth hormone-releasing hormone receptor ligand molecular_function owl:Class
GO:0046618 biolink:NamedThing xenobiotic export The directed movement of a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. got7fsn_ti drug export https://github.com/geneontology/go-ontology/issues/19460 biological_process owl:Class
GO:0102405 biolink:NamedThing (+)-taxifolin 5'-hydroxylase activity Catalysis of the reaction: (+)-taxifolin(1-) + O2 + NADPH(4-) + H+ <=> (+)-dihydromyricetin + NADP(3-) + H2O. got7fsn_ti MetaCyc:RXN-13718|RHEA:61116 molecular_function owl:Class
GO:0034914 biolink:NamedThing trinitrophenol hydride denitratase activity Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP. got7fsn_ti TNP hydride denitratase activity|2,4,6-trinitrophenol hydride denitratase activity EC:1.7.99.-|UM-BBD_reactionID:r1448 molecular_function owl:Class
GO:1990739 biolink:NamedThing granulosa cell proliferation The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. got7fsn_ti sl 2015-05-06T18:56:04Z biological_process owl:Class
GO:0004966 biolink:NamedThing galanin receptor activity Combining with galanin to initiate a change in cell activity. got7fsn_ti molecular_function owl:Class
GO:0036531 biolink:NamedThing glutathione deglycation The removal of a sugar or dicarbonyl from glycated glutathione. Glutathione is the tripeptide glutamylcysteinylglycine. got7fsn_ti bf 2016-08-04T10:45:27Z biological_process owl:Class
GO:0018849 biolink:NamedThing muconate cycloisomerase activity Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate. got7fsn_ti cis,cis-muconate cycloisomerase activity|muconate lactonizing enzyme I activity|muconate cycloisomerase I activity|muconate lactonizing enzyme activity|cis,cis-muconate-lactonizing enzyme https://github.com/geneontology/go-ontology/issues/21794 EC:5.5.1.1|UM-BBD_enzymeID:e0133|MetaCyc:MUCONATE-CYCLOISOMERASE-RXN|RHEA:30031 molecular_function owl:Class
GO:0001179 biolink:NamedThing RNA polymerase I general transcription initiation factor binding Binding to an RNA polymerase I transcription factor, a protein required to initiate or regulate transcription by RNA polymerase I. got7fsn_ti RNA polymerase I transcription factor binding krc 2011-08-12T03:03:03Z molecular_function owl:Class
GO:0072647 biolink:NamedThing interferon-epsilon production The appearance of interferon-epsilon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IFN-epsilon production|interferon-epsilon secretion|IFNE production Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072648 biological_process owl:Class
GO:0048578 biolink:NamedThing positive regulation of long-day photoperiodism, flowering Any process that activates, maintains or increases long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase. got7fsn_ti activation of long-day photoperiodism, flowering|up regulation of long-day photoperiodism, flowering|stimulation of long-day photoperiodism, flowering|upregulation of long-day photoperiodism, flowering|up-regulation of long-day photoperiodism, flowering biological_process owl:Class
GO:0052934 biolink:NamedThing alcohol dehydrogenase (cytochrome c) activity Catalysis of the reaction: 2 [Fe(III)cytochrome c] + a primary alcohol = 2 [Fe(II)cytochrome c] + an aldehyde + 2 H+. got7fsn_ti alcohol:cytochrome c oxidoreductase activity|alcohol dehydrogenase (acceptor) activity|ethanol:cytochrome c oxidoreductase activity|alcohol:(acceptor) oxidoreductase activity|alcohol:acceptor oxidoreductase activity|quinoprotein alcohol dehydrogenase activity|2-chloroethanol:cytochrome c oxidoreductase activity|PQQ-dependent alcohol dehydrogenase activity https://github.com/geneontology/go-ontology/issues/21412 GO:0052936|GO:0052935|GO:0018468 RHEA:51020|KEGG_REACTION:R05198|MetaCyc:RXN-11333|EC:1.1.2.8|KEGG_REACTION:R05285|UM-BBD_enzymeID:e0004 molecular_function owl:Class
GO:0035931 biolink:NamedThing mineralocorticoid secretion The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism. got7fsn_ti bf 2011-07-20T01:04:59Z biological_process owl:Class
GO:0070681 biolink:NamedThing glutaminyl-tRNAGln biosynthesis via transamidation A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase. got7fsn_ti mah 2009-06-02T03:15:57Z MetaCyc:PWY-5921 biological_process owl:Class
GO:0047740 biolink:NamedThing cephalosporin-C transaminase activity Catalysis of the reaction: (7R)-7-(5-carboxylato-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = 2-oxoglutarate + cephalosporin C. got7fsn_ti L-alanine:cephalosporin-C aminotransferase activity|cephalosporin-C:2-oxoglutarate aminotransferase activity|cephalosporin C aminotransferase activity KEGG_REACTION:R03063|RHEA:14553|EC:2.6.1.74|MetaCyc:CEPHALOSPORIN-C-TRANSAMINASE-RXN molecular_function owl:Class
GO:0033639 biolink:NamedThing modulation by symbiont of host response to water Any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0033635 biolink:NamedThing modulation by symbiont of host response to abiotic stimulus Any process in which an organism modulates a change in the state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti biological_process owl:Class
GO:0019640 biolink:NamedThing glucuronate catabolic process to xylulose 5-phosphate The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate. got7fsn_ti glucuronate degradation to xylulose 5-phosphate|glucuronate breakdown to xylulose 5-phosphate biological_process owl:Class
GO:0102483 biolink:NamedThing scopolin beta-glucosidase activity Catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin. got7fsn_ti MetaCyc:RXN-14179|EC:3.2.1.21 molecular_function owl:Class
GO:0004410 biolink:NamedThing homocitrate synthase activity Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate. got7fsn_ti acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity|2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity|acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)|2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)|homocitrate synthetase activity Note that this function was formerly EC:4.1.3.21. MetaCyc:HOMOCITRATE-SYNTHASE-RXN|RHEA:12929|EC:2.3.3.14|KEGG_REACTION:R00271 molecular_function owl:Class
GO:0042997 biolink:NamedThing negative regulation of Golgi to plasma membrane protein transport Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. got7fsn_ti downregulation of Golgi to plasma membrane protein transport|down regulation of Golgi to plasma membrane protein transport|inhibition of Golgi to plasma membrane protein transport|down-regulation of Golgi to plasma membrane protein transport biological_process owl:Class
GO:0009366 biolink:NamedThing enterobactin synthetase complex A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway. got7fsn_ti enterochelin synthetase complex MetaCyc:ENTMULTI-CPLX cellular_component owl:Class
GO:0003825 biolink:NamedThing alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate. got7fsn_ti UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity|trehalose 6-phosphate synthetase activity|UDP-glucose-glucose-phosphate glucosyltransferase activity|uridine diphosphoglucose phosphate glucosyltransferase activity|trehalose 6-phosphate synthase activity|alpha,alpha-trehalose phosphate synthase (UDP-forming)|UDPglucose-glucose-phosphate glucosyltransferase activity|UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity|UDP-glucose-glucosephosphate glucosyltransferase activity|trehalosephosphate-UDP glucosyl transferase activity|trehalose-P synthetase activity|trehalose phosphate synthase activity|trehalose-phosphate synthetase activity|transglucosylase activity|trehalose phosphate synthetase activity|trehalosephosphate-UDP glucosyltransferase activity|trehalose-phosphate synthase activity|phosphotrehalose-uridine diphosphate transglucosylase activity|trehalose phosphate-uridine diphosphate glucosyltransferase activity EC:2.4.1.15|MetaCyc:TREHALOSE6PSYN-RXN|RHEA:18889 molecular_function owl:Class
GO:0047356 biolink:NamedThing CDP-ribitol ribitolphosphotransferase activity Catalysis of the reaction: ribitol phosphate(n) + CDP-ribitol = ribitol phosphate(n+1) + CMP. got7fsn_ti teichoic-acid synthase activity|teichoate synthetase activity|poly(ribitol phosphate) synthetase activity|CDPribitol ribitolphosphotransferase activity|polyribitol phosphate synthetase activity|polyribitol phosphate polymerase activity|CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase activity|teichoate synthase activity RHEA:13353|EC:2.7.8.14|MetaCyc:2.7.8.14-RXN molecular_function owl:Class
GO:0015939 biolink:NamedThing pantothenate metabolic process The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. got7fsn_ti vitamin B5 metabolism|vitamin B5 metabolic process|pantothenate metabolism GO:0006770 biological_process owl:Class
GO:0016287 biolink:NamedThing glycerone-phosphate O-acyltransferase activity Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA. got7fsn_ti acyl-CoA:glycerone-phosphate O-acyltransferase activity|dihydroxyacetone phosphate acyltransferase activity Reactome:R-HSA-75879|KEGG_REACTION:R01013|EC:2.3.1.42|MetaCyc:2.3.1.42-RXN|Reactome:R-HSA-1483002|RHEA:17657 molecular_function owl:Class
GO:0080071 biolink:NamedThing indol-3-yl-methyl-desulfoglucosinolate sulfotransferase activity Catalysis of the reaction: indol-3-yl-methyl-desulfoglucosinolate + 3'-phosphoadenosine 5'-phosphosulfate = indol-3-yl-methyl-glucosinolate + adenosine 3',5'-bisphosphate. got7fsn_ti dhl 2009-04-13T04:08:33Z MetaCyc:RXN-1443 molecular_function owl:Class
GO:0036518 biolink:NamedThing chemorepulsion of dopaminergic neuron axon The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. got7fsn_ti chemorepulsion of dopaminergic axon|chemorepulsion of DA axon bf 2015-12-17T11:29:09Z biological_process owl:Class
GO:0032090 biolink:NamedThing Pyrin domain binding Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain. got7fsn_ti DAPIN domain binding|PAAD domain binding molecular_function owl:Class
GO:0062055 biolink:NamedThing photosynthetic state transition A regulation of the phtosynthetic light reaction in which the light harvesting antenna complexes transition between photosystems. got7fsn_ti dph 2018-07-16T14:00:57Z biological_process owl:Class
GO:0036512 biolink:NamedThing trimming of second mannose on A branch The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum. got7fsn_ti conversion of M8A to M7AA|conversion of (Man)8A(GlcNAc)2 to (Man)7AA(GlcNAc)2|glycoprotein mannose trimming on A branch Consider also annotating to 'mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ; GO:0004571'. bf 2015-06-11T14:16:40Z biological_process owl:Class
GO:0018059 biolink:NamedThing N-terminal peptidyl-serine deamination The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue. got7fsn_ti biological_process owl:Class
GO:0061911 biolink:NamedThing amphisome-lysosome fusion The process in which amphisomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the amphisome. got7fsn_ti dph 2017-07-05T18:54:52Z biological_process owl:Class
GO:0102438 biolink:NamedThing laricitrin 4'-O-methyltransferase activity Catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine <=> H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-13914 molecular_function owl:Class
GO:0042468 biolink:NamedThing klinokinesis The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered. got7fsn_ti biological_process owl:Class
GO:0102528 biolink:NamedThing 7,8,4'-trihydroxyflavone methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone <=> H+ + S-adenosyl-L-homocysteine + 7,4'-dihydroxy, 8-methoxyflavone. got7fsn_ti MetaCyc:RXN-14658 molecular_function owl:Class
GO:0018664 biolink:NamedThing benzoate 4-monooxygenase activity Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+). got7fsn_ti benzoic 4-hydroxylase activity|benzoate 4-hydroxylase activity|benzoic acid 4-hydroxylase activity|p-hydroxybenzoate hydroxylase activity|benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)|benzoate-para-hydroxylase activity|benzoate-p-hydroxylase activity|4-hydroxybenzoic hydroxylase activity EC:1.14.14.92|MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN|KEGG_REACTION:R01295|UM-BBD_reactionID:r0623|RHEA:18033 molecular_function owl:Class
GO:0034520 biolink:NamedThing 2-naphthaldehyde dehydrogenase activity Catalysis of the reaction: 2-naphthaldehyde + NAD+ + H2O = 2-naphthoate + NADH + H+. got7fsn_ti UM-BBD_reactionID:r0772|EC:1.2.1.- molecular_function owl:Class
GO:0034534 biolink:NamedThing 1-methylnaphthalene hydroxylase activity Catalysis of the reaction: 1-methylnaphthalene + NADH + H+ + O2 = 1-hydroxymethylnaphthalene + NAD+ + H2O. got7fsn_ti UM-BBD_reactionID:r0795|EC:1.14.13.- molecular_function owl:Class
GO:0006581 biolink:NamedThing acetylcholine catabolic process The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline. got7fsn_ti acetylcholine degradation|acetylcholine catabolism|acetylcholine breakdown biological_process owl:Class
GO:0008727 biolink:NamedThing GDP-mannose mannosyl hydrolase activity Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+. got7fsn_ti MetaCyc:GDPMANMANHYDRO-RXN|RHEA:28102 molecular_function owl:Class
GO:0033001 biolink:NamedThing Fc-gamma receptor III complex A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG. got7fsn_ti FcgRIII complex|immunoglobulin G receptor complex|IgG receptor complex cellular_component owl:Class
GO:0034788 biolink:NamedThing 2,3-dihydroxy-2'-carboxybiphenyl 1,2-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxy-2'-carboxybiphenyl + O2 = 2-hydroxy-6-oxo-6-(2-carboxyphenyl)-hexa-2,4-dienoate + H+. got7fsn_ti UM-BBD_reactionID:r1041 molecular_function owl:Class
GO:1900550 biolink:NamedThing N',N'',N'''-triacetylfusarinine C catabolic process The chemical reactions and pathways resulting in the breakdown of N',N'',N'''-triacetylfusarinine C. got7fsn_ti N',N'',N'''-triacetylfusarinine C catabolism|N',N'',N'''-triacetylfusarinine C degradation|N',N'',N'''-triacetylfusarinine C breakdown di 2012-05-15T01:00:07Z biological_process owl:Class
GO:0102317 biolink:NamedThing 4-methylaminobutyrate oxidase (demethylating) activity Catalysis of the reaction: 4-(methylamino)butyric acid + O2 + H2O <=> gamma-aminobutyric acid + formaldehyde + hydrogen peroxide. got7fsn_ti MetaCyc:RXN-13067|EC:1.5.3.19|RHEA:33907 molecular_function owl:Class
GO:0050282 biolink:NamedThing serine 2-dehydrogenase activity Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH. got7fsn_ti L-serine:NAD oxidoreductase (deaminating) activity|L-serine:NAD+ 2-oxidoreductase (deaminating)|serine dehydrogenase activity MetaCyc:SERINE-DEHYDROGENASE-RXN|EC:1.4.1.7|RHEA:20884 molecular_function owl:Class
GO:0004706 biolink:NamedThing JUN kinase kinase kinase activity Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). got7fsn_ti JNKKK|JNK kinase kinase activity molecular_function owl:Class
GO:0062071 biolink:NamedThing Pi Mi complex A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis. got7fsn_ti dph 2018-09-04T13:40:52Z cellular_component owl:Class
GO:1990574 biolink:NamedThing meiotic spindle astral microtubule Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell. got7fsn_ti vw 2014-12-04T09:55:09Z cellular_component owl:Class
GO:0033590 biolink:NamedThing response to cobalamin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus. got7fsn_ti response to vitamin B12 biological_process owl:Class
GO:0004415 biolink:NamedThing hyalurononglucosaminidase activity Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. got7fsn_ti hyaluronoglucosidase activity|hyaluronidase activity|chondroitinase activity|chondroitinase I activity|hyaluronoglucosaminidase activity|hyaluronate 4-glycanohydrolase activity Reactome:R-HSA-1793209|EC:3.2.1.35|MetaCyc:3.2.1.35-RXN|Reactome:R-HSA-2160874|Reactome:R-HSA-5693356|Reactome:R-HSA-2160892|Reactome:R-HSA-9036077|Reactome:R-HSA-2318585 molecular_function owl:Class
GO:2000256 biolink:NamedThing positive regulation of male germ cell proliferation Any process that activates or increases the frequency, rate or extent of male germ cell proliferation. got7fsn_ti dph 2010-11-18T09:29:50Z biological_process owl:Class
GO:0043800 biolink:NamedThing hexulose-6-phosphate isomerase activity Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate. got7fsn_ti HUMPI EC:5.3.1.27|MetaCyc:R12-RXN|RHEA:25900 molecular_function owl:Class
GO:0039697 biolink:NamedThing negative stranded viral RNA transcription A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template. got7fsn_ti bf 2013-10-28T14:41:41Z VZ:1096 biological_process owl:Class
GO:0047389 biolink:NamedThing glycerophosphocholine phosphodiesterase activity Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. got7fsn_ti glycerophosphinicocholine diesterase activity|sn-glycero-3-phosphocholine glycerophosphohydrolase activity|glycerylphosphorylcholinediesterase activity|glycerophosphohydrolase activity|glycerolphosphorylcholine phosphodiesterase activity|sn-glycero-3-phosphorylcholine diesterase activity Reactome:R-HSA-6814132|EC:3.1.4.2|MetaCyc:3.1.4.2-RXN|RHEA:16061 molecular_function owl:Class
GO:0043428 biolink:NamedThing 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. got7fsn_ti 2-heptaprenyl-6-methoxy-1,4-benzoquinone methylase activity Note that the polyprenyl sidechain substrate for these methyltransferases varies in length between species, for example, 6 units in S. cerevisiae, 8 units in E. coli and 10 units in G. suboxidans. Where the length of the substrate polyprenyl chain is unknown, the term '2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ; GO:0008425' should be used. MetaCyc:RXN-9227|RHEA:44756 molecular_function owl:Class
GO:0010735 biolink:NamedThing positive regulation of transcription via serum response element binding Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum. got7fsn_ti biological_process owl:Class
GO:0062081 biolink:NamedThing activating MHC class Ib receptor activity Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte. got7fsn_ti dph 2018-10-15T15:05:07Z molecular_function owl:Class
GO:0062122 biolink:NamedThing histone methyltransferase activity (H3-K37 specific) Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 37) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 37). This reaction is the addition of a methyl group onto lysine at position 37 of the histone H3 protein. got7fsn_ti histone lysine N-methyltransferase activity (H3-K37 specific) dph 2019-04-01T13:30:11Z molecular_function owl:Class
GO:0009903 biolink:NamedThing chloroplast avoidance movement The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery. got7fsn_ti high-fluence-rate response biological_process owl:Class
GO:0050089 biolink:NamedThing mannose isomerase activity Catalysis of the reaction: D-mannose = D-fructose. got7fsn_ti D-mannose aldose-ketose-isomerase activity|D-mannose ketol-isomerase activity|D-mannose isomerase activity RHEA:22604|EC:5.3.1.7|KEGG_REACTION:R00877|MetaCyc:MANNOSE-ISOMERASE-RXN molecular_function owl:Class
GO:1990678 biolink:NamedThing histone H4-K16 deacetylation The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone. got7fsn_ti al 2015-03-02T15:25:56Z biological_process owl:Class
GO:0071911 biolink:NamedThing synchronous neurotransmitter secretion Release of neurotransmitter at the synapse that lasts for just a few milliseconds after action potential invasion. got7fsn_ti mah 2010-09-22T01:38:36Z biological_process owl:Class
GO:0052610 biolink:NamedThing beta-cryptoxanthin hydroxylase activity Catalysis of the reaction: beta-cryptoxanthin + a reduced electron acceptor + oxygen = zeaxanthin + an oxidized electron acceptor + H2O. got7fsn_ti carotene beta-ring hydroxylase activity|beta-carotene hydroxylase activity|beta-ring carotenoid 3-hydroxylase activity RHEA:30327|MetaCyc:RXN-8026 molecular_function owl:Class
GO:0046790 biolink:NamedThing virion binding Binding to a virion, either by binding to components of the capsid or the viral envelope. got7fsn_ti molecular_function owl:Class
GO:0018606 biolink:NamedThing benzenesulfonate dioxygenase activity Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol. got7fsn_ti benzenesulphonate dioxygenase activity EC:1.14.12.-|UM-BBD_reactionID:r0295 molecular_function owl:Class
GO:0033900 biolink:NamedThing ribonuclease F activity Catalysis of the endonucleolytic cleavage of RNA precursor into two, leaving 5'-hydroxy and 3'-phosphate groups. got7fsn_ti ribonuclease F (E. coli) activity|RNase F activity EC:3.1.27.7|MetaCyc:3.1.27.7-RXN molecular_function owl:Class
GO:0004144 biolink:NamedThing diacylglycerol O-acyltransferase activity Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. got7fsn_ti palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity|diglyceride acyltransferase activity|diacylglycerol acyltransferase activity|acyl-CoA:1,2-diacylglycerol O-acyltransferase activity|1,2-diacylglycerol acyltransferase activity|diglyceride O-acyltransferase activity RHEA:10868|Reactome:R-HSA-75900|MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN|EC:2.3.1.20|Reactome:R-HSA-8848580|Reactome:R-HSA-1482889|Reactome:R-HSA-549192 molecular_function owl:Class
GO:0014715 biolink:NamedThing myoblast fate commitment in trunk The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:0033797 biolink:NamedThing selenate reductase activity Catalysis of the reaction: 2 e(-) + 2 H(+) + selenate = H(2)O + selenite. got7fsn_ti selenite:reduced acceptor oxidoreductase activity KEGG_REACTION:R07229|EC:1.97.1.9|UM-BBD_reactionID:r0828|RHEA:14029|MetaCyc:RXN0-2101 molecular_function owl:Class
GO:0102261 biolink:NamedThing 8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity Catalysis of the reaction: NADP + a reduced coenzyme F420 <=> NADPH + H+ + an oxidized coenzyme F420. got7fsn_ti RHEA:31363|MetaCyc:RXN-12450|EC:1.5.1.40 molecular_function owl:Class
GO:0097303 biolink:NamedThing lipoprotein biosynthetic process via N-acyl transfer The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex. got7fsn_ti lipoprotein biosynthesis (N-acyl transfer) pr 2012-05-15T01:03:59Z biological_process owl:Class
GO:0098607 biolink:NamedThing methylselenocysteine deselenhydrase activity Catalysis of the reaction: Se-Methyl-L-selenocysteine + H2O => pyruvic acid + NH3 + Methaneselenol. got7fsn_ti dos 2014-04-16T11:24:12Z Reactome:R-HSA-2408539 molecular_function owl:Class
GO:0102464 biolink:NamedThing zeaxanthin 2-beta-hydroxylase activity Catalysis of the reaction: zeaxanthin + O2 + NADH + H+ <=> caloxanthin + H2O + NAD. got7fsn_ti MetaCyc:RXN-14016 molecular_function owl:Class
GO:0032986 biolink:NamedThing protein-DNA complex disassembly The disaggregation of a protein-DNA complex into its constituent components. got7fsn_ti DNA-protein complex disassembly biological_process owl:Class
GO:0097039 biolink:NamedThing protein linear polyubiquitination A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein. got7fsn_ti M1 linkage pr 2011-04-13T01:52:51Z biological_process owl:Class
GO:0021657 biolink:NamedThing rhombomere 2 formation The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order. got7fsn_ti biological_process owl:Class
GO:0106322 biolink:NamedThing S-(hydroxymethyl)glutathione dehydrogenase NAD activity Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+. got7fsn_ti hjd 2020-09-23T15:26:40Z RHEA:19985|EC:1.1.1.284 molecular_function owl:Class
GO:0005044 biolink:NamedThing scavenger receptor activity Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). got7fsn_ti macrophage receptor activity Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0038187' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children. molecular_function owl:Class
GO:0035522 biolink:NamedThing monoubiquitinated histone H2A deubiquitination The removal of the ubiquitin group from a monoubiquitinated histone H2A protein. got7fsn_ti monoubiquitinated histone H2A deubiquitinylation|monoubiquitinated histone H2A deubiquitylation bf 2010-05-04T04:32:53Z biological_process owl:Class
GO:0004613 biolink:NamedThing phosphoenolpyruvate carboxykinase (GTP) activity Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2. got7fsn_ti phosphopyruvate carboxylase (GTP)|phosphoenolpyruvic carboxykinase (GTP)|phosphoenolpyruvic carboxylase (GTP)|phosphoenolpyruvate carboxylase (GTP)|GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)|GTP:oxaloacetate carboxy-lyase (transphosphorylating)|phosphopyruvate (guanosine triphosphate) carboxykinase activity|phosphoenolpyruvic carboxykinase RHEA:10388|Reactome:R-HSA-70241|EC:4.1.1.32|Reactome:R-HSA-372819|MetaCyc:4.1.1.32-RXN molecular_function owl:Class
GO:0048361 biolink:NamedThing root epithelial mucilage metabolic process The chemical reactions and pathways involving mucilage that occur in the root epithelium; mucilage is normally synthesized during root growth. got7fsn_ti root epithelial mucilage metabolism biological_process owl:Class
GO:0051680 biolink:NamedThing 6-alpha-maltosylglucose biosynthetic process The chemical reactions and pathways resulting in the formation of 6-alpha-maltosylglucose, also known as isopanose. got7fsn_ti isopanose biosynthesis|isopanose biosynthetic process biological_process owl:Class
GO:0004776 biolink:NamedThing succinate-CoA ligase (GDP-forming) activity Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate. got7fsn_ti succinyl coenzyme A synthetase|succinic thiokinase|succinyl CoA synthetase activity|succinate-phosphorylating enzyme|succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity|P-enzyme|succinyl-CoA synthetase (GDP-forming) activity|succinate:CoA ligase (GDP-forming) activity|succinyl coenzyme A synthetase (GDP-forming) activity|G-STK|SCS Reactome:R-HSA-71775|MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN|EC:6.2.1.4|RHEA:22120|KEGG_REACTION:R00432 molecular_function owl:Class
GO:0047365 biolink:NamedThing quercetin-3-sulfate 3'-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,3'-disulfate. got7fsn_ti flavonol 3'-sulfotransferase activity|quercetin-3-sulphate 3'-sulphotransferase activity|3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase activity|3'-sulfotransferase activity|PAPS:flavonol 3-sulfate 3'-sulfotransferase activity KEGG_REACTION:R02632|MetaCyc:2.8.2.26-RXN|EC:2.8.2.26|RHEA:22504 molecular_function owl:Class
GO:0004343 biolink:NamedThing glucosamine 6-phosphate N-acetyltransferase activity Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+). got7fsn_ti D-glucosamine-6-P N-acetyltransferase activity|acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity|glucosamine-6-phosphate acetylase activity|N-acetylglucosamine-6-phosphate synthase activity|phosphoglucosamine N-acetylase activity|glucosamine 6-phosphate acetylase activity|glucosamine-phosphate N-acetyltransferase activity|aminodeoxyglucosephosphate acetyltransferase activity|phosphoglucosamine acetylase activity|phosphoglucosamine transacetylase activity EC:2.3.1.4|MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN|RHEA:10292|KEGG_REACTION:R02058|Reactome:R-HSA-449734 molecular_function owl:Class
GO:0061821 biolink:NamedThing telomeric D-loop binding Binding to a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus. got7fsn_ti telomeric Displacement-loop binding dph molecular_function owl:Class
GO:0034668 biolink:NamedThing integrin alpha4-beta1 complex An integrin complex that comprises one alpha4 subunit and one beta1 subunit. got7fsn_ti alpha4-beta1 integrin complex|VLA-4 complex|ITGA4-ITGB1 complex cellular_component owl:Class
GO:0050064 biolink:NamedThing luteolin 7-O-glucuronosyltransferase activity Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP. got7fsn_ti luteolin 7-O-glucoronosyltransferase activity|uridine diphosphoglucuronate-luteolin 7-O-glucuronosyltransferase activity|UDP-glucuronate:luteolin 7-O-glucuronosyltransferase activity|LGT|UDPglucuronate:luteolin 7-O-glucuronosyltransferase activity KEGG_REACTION:R03589|EC:2.4.1.189|RHEA:10568|MetaCyc:LUTEOLIN-7-O-GLUCORONOSYLTRANSFERASE-RXN molecular_function owl:Class
GO:0052823 biolink:NamedThing 2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+. got7fsn_ti 2-hydroxy-6-ketonona-2,4,7-trienedoic acid hydrolase activity|(2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate fumarylhydrolase activity ai 2011-10-28T03:28:37Z EC:3.7.1.14|MetaCyc:RXN-12070|RHEA:25046|UM-BBD_reactionID:r1622 molecular_function owl:Class
GO:0021929 biolink:NamedThing stellate cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0018444 biolink:NamedThing translation release factor complex A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome. got7fsn_ti eukaryotic peptide chain release factor|peptide chain release factor cellular_component owl:Class
GO:0031423 biolink:NamedThing hexon binding Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus. got7fsn_ti molecular_function owl:Class
GO:0036088 biolink:NamedThing D-serine catabolic process The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. got7fsn_ti D-serine catabolism|D-serine degradation|D-serine breakdown bf 2012-01-06T10:58:51Z biological_process owl:Class
GO:0030516 biolink:NamedThing regulation of axon extension Any process that modulates the rate, direction or extent of axon extension. got7fsn_ti biological_process owl:Class
GO:0046679 biolink:NamedThing response to streptomycin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a streptomycin stimulus. Streptomycin is a commonly used antibiotic in cell culture media which acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome. got7fsn_ti streptomycin susceptibility/resistance biological_process owl:Class
GO:0102236 biolink:NamedThing trans-4-hexen-3-one reductase activity Catalysis of the reaction: trans-4-hexen-3-one + NADPH + H+ <=> hexan-3-one + NADP. got7fsn_ti MetaCyc:RXN-12296 molecular_function owl:Class
GO:0102532 biolink:NamedThing genkwanin 6-hydroxylase activity Catalysis of the reaction: genkwanin + O2 + NADPH + H+ <=> scutellarein 7-methyl ether + H2O + NADP. got7fsn_ti MetaCyc:RXN-14748 molecular_function owl:Class
GO:0047265 biolink:NamedThing poly(glycerol-phosphate) alpha-glucosyltransferase activity Catalysis of the reaction: poly(glycerol phosphate) + UDP-D-glucose = alpha-D-glucosylpoly(glycerol phosphate) + UDP. got7fsn_ti UDP glucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity|UDPglucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity|UDP-glucose:poly(glycerol-phosphate) alpha-D-glucosyltransferase activity|uridine diphosphoglucose-poly(glycerol-phosphate) alpha-glucosyltransferase activity MetaCyc:2.4.1.52-RXN|EC:2.4.1.52|RHEA:15845 molecular_function owl:Class
GO:0033932 biolink:NamedThing 1,3-alpha-L-fucosidase activity Catalysis of the hydrolysis of (1->3) linkages between alpha-L-fucose and N-acetylglucosamine residues in glycoproteins. got7fsn_ti 3-alpha-L-fucosyl-N-acetylglucosaminyl-glycoprotein fucohydrolase activity|almond emulsin fucosidase I activity MetaCyc:3.2.1.111-RXN|EC:3.2.1.111 molecular_function owl:Class
GO:0120138 biolink:NamedThing regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. got7fsn_ti krc 2018-03-22T16:15:08Z biological_process owl:Class
GO:0033698 biolink:NamedThing Rpd3L complex A histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae). got7fsn_ti Clr6L complex|Clr6 histone deacetylase complex I/I'|Rpd3C(L) GO:0000508 cellular_component owl:Class
GO:0046429 biolink:NamedThing 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + 2 oxidized ferredoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + 2 reduced ferredoxin. got7fsn_ti (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase activity|1-hydroxy-2-methyl-2-butenyl 4-diphosphate synthase activity|1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase activity|(E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:oxidized ferredoxin oxidoreductase activity MetaCyc:RXN0-882|RHEA:26119|KEGG_REACTION:R08689|EC:1.17.7.1 molecular_function owl:Class
GO:0098994 biolink:NamedThing disruption of host cell envelope during viral entry The disruption of host cell envelope by viral proteins during virus entry. got7fsn_ti VZ:3938 biological_process owl:Class
GO:0090577 biolink:NamedThing RNA polymerase IV transcription regulator complex A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV. got7fsn_ti RNA polymerase IV transcription factor complex tb 2014-05-09T14:04:37Z cellular_component owl:Class
GO:0043906 biolink:NamedThing Ala-tRNA(Pro) hydrolase activity Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro). got7fsn_ti Ala-tRNAPro hydrolase activity EC:3.1.1.- molecular_function owl:Class
GO:0019162 biolink:NamedThing pyridoxamine-oxaloacetate transaminase activity Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal. got7fsn_ti pyridoxamine--oxaloacetate aminotransferase activity|pyridoxamine:oxaloacetate aminotransferase activity|pyridoxamine-oxaloacetate aminotransferase activity MetaCyc:PYROXALTRANSAM-RXN|EC:2.6.1.31|KEGG_REACTION:R01713|RHEA:10844 molecular_function owl:Class
GO:1990828 biolink:NamedThing hepatocyte dedifferentiation The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors. got7fsn_ti sl 2015-08-20T14:14:57Z biological_process owl:Class
GO:0004310 biolink:NamedThing farnesyl-diphosphate farnesyltransferase activity Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. got7fsn_ti presqualene-diphosphate synthase activity|presqualene synthase activity|farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. Reactome:R-HSA-191405|MetaCyc:2.5.1.21-RXN|Reactome:R-HSA-191402|EC:2.5.1.21 molecular_function owl:Class
GO:0047662 biolink:NamedThing aminobenzoate decarboxylase activity Catalysis of the reaction: 4(or 2)-aminobenzoate = aniline + CO2. got7fsn_ti aminobenzoate carboxy-lyase (aniline-forming)|aminobenzoate carboxy-lyase activity EC:4.1.1.24|MetaCyc:AMINOBENZOATE-DECARBOXYLASE-RXN|RHEA:24200 molecular_function owl:Class
GO:0033890 biolink:NamedThing ribonuclease D activity Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides. got7fsn_ti RNase D activity EC:3.1.13.5|MetaCyc:3.1.13.5-RXN molecular_function owl:Class
GO:0047423 biolink:NamedThing N-methylhydantoinase (ATP-hydrolyzing) activity Catalysis of the reaction: N-methylhydantoin + ATP + 2 H(2)O = N-carbamoylsarcosine + ADP + 3 H(+) + phosphate. got7fsn_ti N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing)|N-methylhydantoinase (ATP-hydrolysing)|N-methylhydantoinase activity|methylhydantoin amidase activity|N-methylhydantoin hydrolase activity|N-methylhydantoin amidohydrolase activity Wikipedia:N-methylhydantoinase_(ATP-hydrolysing)|KEGG_REACTION:R03187|RHEA:11720|EC:3.5.2.14|MetaCyc:3.5.2.14-RXN molecular_function owl:Class
GO:0021810 biolink:NamedThing neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration. got7fsn_ti neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration biological_process owl:Class
GO:0071208 biolink:NamedThing histone pre-mRNA DCP binding Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing. got7fsn_ti mah 2009-11-25T01:41:35Z molecular_function owl:Class
GO:0034186 biolink:NamedThing apolipoprotein A-I binding Binding to apolipoprotein A-I. got7fsn_ti molecular_function owl:Class
GO:0034418 biolink:NamedThing urate biosynthetic process The chemical reactions and pathways resulting in the formation of urate, the anion of uric acid, 2,6,8-trioxypurine. got7fsn_ti urate biosynthesis|urate synthesis|uric acid biosynthetic process|urate anabolism|urate formation biological_process owl:Class
GO:0102051 biolink:NamedThing indole-3-acetyl-tryptophan synthetase activity Catalysis of the reaction: indole-3-acetate + L-tryptophan + ATP(4-) <=> H+ + indole-3-acetyl-tryptophan + AMP(2-) + diphosphoric acid. got7fsn_ti MetaCyc:RXN-10433 molecular_function owl:Class
GO:0047922 biolink:NamedThing gentisate 1,2-dioxygenase activity Catalysis of the reaction: 2,5-dihydroxybenzoate + O(2) = 3-maleylpyruvate + H(+). got7fsn_ti 2,5-dihydroxybenzoate dioxygenase activity|gentisate dioxygenase activity|gentisate:oxygen 1,2-oxidoreductase (decyclizing)|gentisate oxygenase activity|gentisic acid oxidase activity RHEA:18237|KEGG_REACTION:R02656|MetaCyc:GENTISATE-12-DIOXYGENASE-RXN|EC:1.13.11.4 molecular_function owl:Class
GO:0071210 biolink:NamedThing protein insertion into membrane raft The process in which a protein is incorporated into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. got7fsn_ti establishment of protein localization to membrane raft mah 2009-11-25T02:11:46Z biological_process owl:Class
GO:0000091 biolink:NamedThing mitotic anaphase A The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis. got7fsn_ti Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0062130 biolink:NamedThing adhesive extracellular matrix A extracellular matrix which attaches an organism to a substrate. got7fsn_ti puparial glue dph 2019-06-21T12:35:06Z cellular_component owl:Class
GO:1990448 biolink:NamedThing exon-exon junction complex binding Binding to an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. got7fsn_ti EJC binding sart 2014-08-06T10:02:46Z molecular_function owl:Class
GO:0031464 biolink:NamedThing Cul4A-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. got7fsn_ti SCF4 complex|CDL4 complex|VDC complex|cullin-RING ligase 4A|CRL4 complex|DCX complex cellular_component owl:Class
GO:0010276 biolink:NamedThing phytol kinase activity Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+. got7fsn_ti EC:2.7.1.182|RHEA:38055|MetaCyc:RXN-7683 molecular_function owl:Class
GO:1990309 biolink:NamedThing type-II dockerin domain binding Binding to a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain. got7fsn_ti tt 2014-03-07T03:16:49Z molecular_function owl:Class
GO:0022020 biolink:NamedThing medial ganglionic eminence cell proliferation The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population. got7fsn_ti biological_process owl:Class
GO:0050798 biolink:NamedThing activated T cell proliferation The expansion of a T cell population following activation by an antigenic stimulus. got7fsn_ti activated T-cell proliferation|activated T lymphocyte proliferation|activated T-lymphocyte proliferation|proliferation of activated T cells Note that this term refers to the proliferation of previously activated T cells; it is to be used for gene products involved in T cell proliferation following an antigenic stimulus, including both proteins internal to the T cell and external factors, such as IL-2, which specifically promote proliferation of activated T cells. biological_process owl:Class
GO:0047317 biolink:NamedThing N6-acetyl-beta-lysine transaminase activity Catalysis of the reaction: 2-oxoglutarate + 3-amino-6-acetamidohexanoate = L-glutamate + 3-oxo-6-acetamidohexanoate. got7fsn_ti 6-acetamido-3-aminohexanoate:2-oxoglutarate aminotransferase activity|epsilon-acetyl-beta-lysine aminotransferase activity|N(6)-acetyl-beta-lysine aminotransferase activity|N6-acetyl-beta-lysine aminotransferase activity RHEA:16889|MetaCyc:2.6.1.65-RXN|EC:2.6.1.65 molecular_function owl:Class
GO:0047605 biolink:NamedThing acetolactate decarboxylase activity Catalysis of the reaction: (S)-2-hydroxy-2-methyl-3-oxobutanoate = (R)-2-acetoin + CO2. got7fsn_ti alpha-acetolactate decarboxylase activity|(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase [(R)-2-acetoin-forming]|(S)-2-hydroxy-2-methyl-3-oxobutanoate carboxy-lyase activity MetaCyc:ACETOLACTATE-DECARBOXYLASE-RXN|RHEA:21580|EC:4.1.1.5 molecular_function owl:Class
GO:0000831 biolink:NamedThing inositol hexakisphosphate 6-kinase activity Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate. got7fsn_ti molecular_function owl:Class
GO:0008330 biolink:NamedThing protein tyrosine/threonine phosphatase activity Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. got7fsn_ti molecular_function owl:Class
GO:0003121 biolink:NamedThing epinephrine-mediated vasodilation A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings. got7fsn_ti regulation of vasodilation by neuronal epinephrine|regulation of vasodilation by adrenaline|regulation of vasodilation by epinephrine|regulation of vasodilation by circulating adrenaline|regulation of vasodilation by neuronal adrenaline|regulation of vasodilation by circulating epinephrine GO:0003123|GO:0003124 biological_process owl:Class
GO:0102670 biolink:NamedThing 2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity Catalysis of the reaction: 2,4',7-trihydroxyisoflavanone + S-adenosyl-L-methionine <=> H+ + 2,7-dihydroxy-4'-methoxyisoflavanone + S-adenosyl-L-homocysteine. got7fsn_ti RHEA:31371|EC:2.1.1.212|MetaCyc:RXN-3624 molecular_function owl:Class
GO:0031762 biolink:NamedThing follicle-stimulating hormone receptor binding Binding to a follicle-stimulating hormone receptor. got7fsn_ti follicle stimulating hormone receptor ligand|follicle stimulating hormone receptor binding|FSH receptor binding molecular_function owl:Class
GO:0061567 biolink:NamedThing dCMP phosphorylation The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP. got7fsn_ti dph 2013-08-01T12:54:21Z biological_process owl:Class
GO:0004639 biolink:NamedThing phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate. got7fsn_ti SAICARs activity|SAICAR synthetase activity|SAICAR synthase activity|4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity|5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)|phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity|5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity|4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity|phosphoribosylaminoimidazole-succinocarboxamide synthase activity|PurC|phosphoribosylaminoimidazole-succinocarboxamide synthetase activity|4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity Reactome:R-HSA-73805|RHEA:22628|MetaCyc:SAICARSYN-RXN|EC:6.3.2.6|KEGG_REACTION:R04591 molecular_function owl:Class
GO:0050343 biolink:NamedThing trans-2-enoyl-CoA reductase (NAD+) activity Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH. got7fsn_ti acyl-CoA:NAD+ trans-2-oxidoreductase activity EC:1.3.1.44|MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN|RHEA:18177 molecular_function owl:Class
GO:0061477 biolink:NamedThing response to aromatase inhibitor Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus. got7fsn_ti dph 2012-11-07T09:08:36Z biological_process owl:Class
GO:0033794 biolink:NamedThing sarcosine reductase activity Catalysis of the reaction: acetyl phosphate + methylamine + thioredoxin disulfide = N-methylglycine + phosphate + thioredoxin. got7fsn_ti acetyl-phosphate methylamine:thioredoxin disulfide oxidoreductase (N-methylglycine-forming) activity EC:1.21.4.3|RHEA:12825 molecular_function owl:Class
GO:0044527 biolink:NamedThing formation of peptidyl-cystine persulfide by sulphur transfer from H2S The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide. got7fsn_ti jl 2012-03-15T09:46:23Z biological_process owl:Class
GO:0016540 biolink:NamedThing protein autoprocessing Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. got7fsn_ti biological_process owl:Class
GO:0030639 biolink:NamedThing polyketide biosynthetic process The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps. got7fsn_ti polyketide formation|polyketide synthesis|polyketide biosynthesis|polyketide anabolism biological_process owl:Class
GO:0097076 biolink:NamedThing transforming growth factor beta activated kinase 1 complex A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits). got7fsn_ti TAK1 kinase complex pr 2011-06-15T04:55:32Z cellular_component owl:Class
GO:0098677 biolink:NamedThing virion maturation Maturation of a virion after separation from the host cell. Not all viruses mature after separation. In those that do, maturation typically involves rearangement and/or cleavage of viral proteins, resulting in the virion becoming competent for reinfection. got7fsn_ti virus particle maturation|viral particle maturation dos 2017-01-19T12:49:22Z UniProtKB-KW:KW-0917|VZ:1946 biological_process owl:Class
GO:0005175 biolink:NamedThing CD27 receptor binding Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells. got7fsn_ti molecular_function owl:Class
GO:2000141 biolink:NamedThing positive regulation of octopamine signaling pathway involved in response to food Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food. got7fsn_ti positive regulation of octopamine signalling pathway involved in response to food mah 2010-09-30T02:48:12Z biological_process owl:Class
GO:0032216 biolink:NamedThing glucosaminyl-phosphatidylinositol O-acyltransferase activity Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA. got7fsn_ti glucosaminyl-phosphotidylinositol O-acyltransferase activity|GPI-inositol acyltransferase molecular_function owl:Class
GO:0001955 biolink:NamedThing blood vessel maturation A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. got7fsn_ti biological_process owl:Class
GO:0047137 biolink:NamedThing N-hydroxy-2-acetamidofluorene reductase activity Catalysis of the reaction: 2-acetamidofluorene + NAD(P)+ + H2O = N-hydroxy-2-acetamidofluorene + NAD(P)H + H+. got7fsn_ti N-hydroxy-2-acetylaminofluorene reductase activity|2-acetamidofluorene:NAD(P)+ oxidoreductase activity|NAD(P)H:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity|NAD(P)H2:N-hydroxy-2-acetamidofluorene N-oxidoreductase activity EC:1.7.1.12|MetaCyc:1.7.1.12-RXN molecular_function owl:Class
GO:0102804 biolink:NamedThing oripavine 6-O-demethylase activity Catalysis of the reaction: oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-8151|EC:1.14.11.31 molecular_function owl:Class
GO:0047575 biolink:NamedThing 4-carboxymuconolactone decarboxylase activity Catalysis of the reaction: (R)-2-(carboxymethyl)-5-oxo-2,5-dihydro-2-furoate + H(+) = 5-oxo-4,5-dihydro-2-furylacetate + CO(2). got7fsn_ti 4-carboxymuconolactone carboxy-lyase (4,5-dihydro-5-oxofuran-2-acetate-forming)|gamma-4-carboxymuconolactone decarboxylase activity|4-carboxymonolactone carboxy-lyase activity|4-carboxymuconolactone carboxy-lyase activity RHEA:23348|KEGG_REACTION:R03470|EC:4.1.1.44|MetaCyc:4-CARBOXYMUCONOLACTONE-DECARBOXYLASE-RXN molecular_function owl:Class
GO:0018492 biolink:NamedThing carbon-monoxide dehydrogenase (acceptor) activity Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor. got7fsn_ti carbon-monoxide:acceptor oxidoreductase activity|carbon monoxide dehydrogenase activity|anaerobic carbon monoxide dehydrogenase activity EC:1.2.7.4|RHEA:21040|UM-BBD_enzymeID:e0415|MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN molecular_function owl:Class
GO:1904126 biolink:NamedThing convergent extension involved in notochord morphogenesis Any convergent extension that is involved in notochord morphogenesis. got7fsn_ti dph 2015-04-10T21:12:57Z biological_process owl:Class
GO:0071547 biolink:NamedThing piP-body A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway. got7fsn_ti mah 2010-01-12T05:47:47Z cellular_component owl:Class
GO:0106309 biolink:NamedThing progesterone 21-hydroxylase activity Catalysis of the reaction: O2 + progesterone + reduced [NADPH--hemoprotein reductase] = 21-hydroxyprogesterone + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti hjd 2020-09-21T14:40:30Z RHEA:50304 molecular_function owl:Class
GO:0120171 biolink:NamedThing Cdc24p-Far1p-Gbetagamma complex A complex that forms at the cell cortex in response to pheromone treatment and is required for the polarized growth of haploid yeast cells towards a mating partner during yeast mating. In the yeast Saccharomyces cerevisiae, this complex consists of Cdc24p, Far1p, Ste4p (G-protein beta subunit) and Ste18p (G-protein gamma subunit). got7fsn_ti Cdc24p-Far1p-BG complex|CDC24-FAR1-BG complex|CDC24-FAR1-Gbetagamma complex krc 2018-05-31T17:11:20Z cellular_component owl:Class
GO:1990485 biolink:NamedThing anaerobic lactate catabolic process The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen. got7fsn_ti anaerobic lactic acid catabolic process tt 2014-09-20T16:48:06Z biological_process owl:Class
GO:0099141 biolink:NamedThing cellular response to protozoan Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan. got7fsn_ti biological_process owl:Class
GO:0075138 biolink:NamedThing response to host oxygen tension environment Any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting oxygen tension in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti response of symbiont to host oxygen tension environment Note that this term is used to annotate gene products of the symbiont. biological_process owl:Class
GO:0098515 biolink:NamedThing detection of low humidity stimulus involved in sensory perception The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity. got7fsn_ti dos 2013-09-25T14:24:29Z biological_process owl:Class
GO:0019948 biolink:NamedThing SUMO activating enzyme activity Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond. got7fsn_ti SUMO E1 activator enzyme|SMT3 activating enzyme GO:0017115 Reactome:R-HSA-2990833|Reactome:R-HSA-2993781|Reactome:R-HSA-2993784 molecular_function owl:Class
GO:0003786 biolink:NamedThing actin lateral binding Binding to an actin filament along its length. got7fsn_ti molecular_function owl:Class
GO:0061227 biolink:NamedThing pattern specification involved in mesonephros development Any developmental process that results in the creation of defined areas or spaces within the mesonephros to which cells respond and eventually are instructed to differentiate. got7fsn_ti mesonephros pattern formation|mesonephros pattern specification dph 2010-08-19T02:22:22Z biological_process owl:Class
GO:0052088 biolink:NamedThing symbiont defense to host-produced jasmonic acid Any process in which a symbiont modulates the frequency, rate or extent of the jasmonic acid-mediated defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|modulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|positive regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|upregulation by organism of defense-related host jasmonic acid-mediated signal transduction pathway|inhibition by symbiont of host jasmonic acid-mediated defense response|induction by organism of defense-related host SA-mediated signal transduction pathway|activation by organism of defense-related host SA-mediated signal transduction pathway|modulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|down regulation by symbiont of host jasmonic acid-mediated defense response|upregulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|activation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|activation by organism of defense-related host jasmonic acid-mediated signal transduction pathway|downregulation by symbiont of host jasmonic acid-mediated defense response|positive regulation by organism of defense-related host SA-mediated signal transduction pathway|induction by organism of defense-related host jasmonic acid-mediated signal transduction pathway|suppression by organism of host JA-mediated defense response|positive regulation by organism of defense-related jasmonic acid-mediated signal transduction pathway in other organism involved in symbiotic interaction|modulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction|negative regulation by symbiont of host jasmonic acid-mediated defense response|suppression by symbiont of host jasmonic acid-mediated defense response|negative regulation by organism of jasmonic acid-mediated defense response of other organism involved in symbiotic interaction|induction by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|upregulation by organism of defense-related host SA-mediated signal transduction pathway|up-regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|up regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|down-regulation by symbiont of host jasmonic acid-mediated defense response|modulation by organism of host JA-mediated defense response|negative regulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway|stimulation by symbiont of defense-related host jasmonic acid-mediated signal transduction pathway https://github.com/geneontology/go-ontology/issues/18798 GO:0052082|GO:0052073|GO:0052266|GO:0052068|GO:0052271|GO:0052267|GO:0052069|GO:0052443|GO:0052283 biological_process owl:Class
GO:0140337 biolink:NamedThing diacylglyceride transfer activity Directly binding to diacylglyceride and delivering it either to an acceptor molecule or to a specific location. got7fsn_ti diacylglyceride carrier activity pg 2019-05-16T11:28:08Z molecular_function owl:Class
GO:0034932 biolink:NamedThing 1-methoxypyrene 6,7-monooxygenase activity Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O. got7fsn_ti UM-BBD_reactionID:r0954 molecular_function owl:Class
GO:0004530 biolink:NamedThing deoxyribonuclease I activity Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. got7fsn_ti DNase activity|alkaline DNase activity|DNase I|DNA nuclease activity|DNA endonuclease activity|endodeoxyribonuclease I|pancreatic dornase|deoxyribonuclease (pancreatic)|thymonuclease activity|dornavac|DNAase activity|pancreatic deoxyribonuclease|thymonuclease, dornase activity|deoxyribonucleic phosphatase activity|alkaline deoxyribonuclease activity|deoxyribonuclease A|Escherichia coli endonuclease I|dornava|DNA depolymerase activity|pancreatic DNase activity MetaCyc:3.1.21.1-RXN|EC:3.1.21.1 molecular_function owl:Class
GO:0018965 biolink:NamedThing s-triazine compound metabolic process The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms. got7fsn_ti s-triazine compound metabolism UM-BBD_pathwayID:tria biological_process owl:Class
GO:0099609 biolink:NamedThing microtubule lateral binding Binding to the side of a microtubule. got7fsn_ti molecular_function owl:Class
GO:0046462 biolink:NamedThing monoacylglycerol metabolic process The chemical reactions and pathways involving monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. got7fsn_ti monoacylglycerol metabolism|monoglyceride metabolic process|monoglyceride metabolism biological_process owl:Class
GO:0033943 biolink:NamedThing galactan 1,3-beta-galactosidase activity Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in (1->3)-beta-D-galactopyranans. got7fsn_ti galactan (1,3)-beta-D-galactosidase activity|galactan (1->3)-beta-D-galactosidase activity MetaCyc:3.2.1.145-RXN|EC:3.2.1.145 molecular_function owl:Class
GO:0043758 biolink:NamedThing acetate-CoA ligase (ADP-forming) activity Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA. got7fsn_ti acetate--CoA ligase (ADP-forming) activity|acetate:CoA ligase (ADP-forming)|acetate thiokinase activity|acetyl coenzyme A synthetase (adenosine diphosphate-forming)|acetyl-CoA synthetase (ADP-forming) activity|aryl-CoA synthetase (ADP-forming) activity GO:0043762 RHEA:15081|MetaCyc:ACETATE--COA-LIGASE-ADP-FORMING-RXN|EC:6.2.1.13 molecular_function owl:Class
GO:0015915 biolink:NamedThing fatty-acyl group transport The directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid. got7fsn_ti fatty acyl transport biological_process owl:Class
GO:0045134 biolink:NamedThing uridine-diphosphatase activity Catalysis of the reaction: UDP + H2O = UMP + phosphate. got7fsn_ti uridine diphosphatase activity|UDPase activity|UDP phosphohydrolase activity|uridine 5'-diphosphatase activity RHEA:64876|EC:3.6.1.6|KEGG_REACTION:R00155|MetaCyc:RXN-12197 molecular_function owl:Class
GO:0062083 biolink:NamedThing HLA-G specific inhibitory MHC class Ib receptor activity Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte. got7fsn_ti dph 2018-10-15T15:06:44Z molecular_function owl:Class
GO:0036436 biolink:NamedThing Isw1a complex An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p. got7fsn_ti bf 2013-09-18T16:45:41Z cellular_component owl:Class
GO:0102533 biolink:NamedThing genkwanin 4'-O-methyltransferase activity Catalysis of the reaction: genkwanin + S-adenosyl-L-methionine <=> H+ + apigenin-7,4'-dimethyl ether + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-14750 molecular_function owl:Class
GO:0005983 biolink:NamedThing starch catabolic process The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants. got7fsn_ti starch catabolism|starch breakdown|starch degradation MetaCyc:PWY-842 biological_process owl:Class
GO:0031789 biolink:NamedThing G protein-coupled acetylcholine receptor binding Binding to a G protein-coupled acetylcholine receptor. got7fsn_ti M5 muscarinic acetylcholine receptor binding|M3 muscarinic acetylcholine receptor binding|M2 muscarinic acetylcholine receptor ligand|M4 muscarinic acetylcholine receptor binding|M2 muscarinic acetylcholine receptor binding|M5 muscarinic acetylcholine receptor ligand|G-protein coupled acetylcholine receptor binding|M1 muscarinic acetylcholine receptor binding|M3 muscarinic acetylcholine receptor ligand|M1 muscarinic acetylcholine receptor ligand|muscarinic acetylcholine receptor binding|muscarinic acetylcholine receptor ligand|M4 muscarinic acetylcholine receptor ligand GO:0031791|GO:0031790|GO:0031793|GO:0031792|GO:0031794 molecular_function owl:Class
GO:0102619 biolink:NamedThing oryzalexin C synthase (oryzalexin A dependent) activity Catalysis of the reaction: oryzalexin A + NAD(P) <=> oryzalexin C + H+ + NAD(P)H. got7fsn_ti MetaCyc:RXN-15467 molecular_function owl:Class
GO:0043420 biolink:NamedThing anthranilate metabolic process The chemical reactions and pathways involving anthranilate (2-aminobenzoate). got7fsn_ti anthranilic acid metabolism|2-aminobenzoate metabolism|2-aminobenzoate metabolic process|ortho-aminobenzoic acid metabolic process|anthranilic acid metabolic process|ortho-aminobenzoic acid metabolism|anthranilate metabolism GO:0018869 UM-BBD_pathwayID:abz2 biological_process owl:Class
GO:0106277 biolink:NamedThing biliverdin reductase (NADP+) activity Catalysis of the reaction: bilirubin + NADP+ = biliverdin + NADPH + H+. got7fsn_ti hjd 2020-07-02T01:50:24Z RHEA:15793|EC:1.3.1.24 molecular_function owl:Class
GO:0062192 biolink:NamedThing L-rhamnose mutarotase activity Catalysis of the reaction: alpha-L-rhamnose = beta-L-rhamnose. got7fsn_ti dph 2019-12-09T16:45:45Z RHEA:25584|EC:5.1.3.32 molecular_function owl:Class
GO:0070267 biolink:NamedThing oncosis A cellular process that results in swelling of the cell body, and that is morphologically characteristic of necrotic cell death. got7fsn_ti Note that oncosis is sometimes described as a type of cell death, but recent nomenclature recommendations define it as a feature of necrotic cell death rather than a distinct mode of cell death. biological_process owl:Class
GO:0061616 biolink:NamedThing glycolytic process from fructose through fructose-6-phosphate The glycolytic process through fructose-6-phosphate in which fructose is catabolized into pyruvate. got7fsn_ti glycolysis from fructose through fructose-6-phosphate dph 2014-04-08T10:20:37Z MetaCyc:PWY-5484 biological_process owl:Class
GO:0106326 biolink:NamedThing acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity Catalysis of the reaction: 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-beta-D-glucosaminyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + H(+) + UDP. got7fsn_ti hjd 2020-09-30T13:40:25Z RHEA:56192|EC:2.4.1.148 molecular_function owl:Class
GO:0019650 biolink:NamedThing glycolytic fermentation to butanediol The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into butanediol; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia. got7fsn_ti glucose fermentation to butanediol|glucose catabolic process to butanediol|butanediol fermentation GO:0030646 MetaCyc:P125-PWY|Wikipedia:Butanediol_fermentation biological_process owl:Class
GO:1990082 biolink:NamedThing DnaA-L2 complex A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2. got7fsn_ti bhm 2013-04-30T11:46:41Z cellular_component owl:Class
GO:0046961 biolink:NamedThing proton-transporting ATPase activity, rotational mechanism Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. got7fsn_ti F(1)-ATPase activity|F0F1-ATPase|F(o)F(1)-ATPase activity|ATP phosphohydrolase (H+-transporting) activity|ATP synthase activity|mitochondrial ATPase activity|hydrogen ion translocating F-type ATPase activity|hydrogen ion transporting ATPase activity, rotational mechanism|hydrogen ion translocating A-type ATPase activity|H+-transporting ATPase activity|FoF1-ATPase|hydrogen ion transporting two-sector ATPase activity|F(0)F(1)-ATPase activity|hydrogen ion translocating V-type ATPase activity|H(+)-transporting ATP synthase activity|chloroplast ATPase activity|F1-ATPase EC:7.1.2.2|MetaCyc:ATPSYN-RXN|RHEA:57721 molecular_function owl:Class
GO:0043131 biolink:NamedThing erythrocyte enucleation The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation. got7fsn_ti biological_process owl:Class
GO:0048835 biolink:NamedThing specification of decreased petal number Any process that reduces the number of petals produced in a developing flower. got7fsn_ti biological_process owl:Class
GO:0050062 biolink:NamedThing long-chain-fatty-acyl-CoA reductase activity Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH. got7fsn_ti acyl coenzyme A reductase activity|long-chain fatty acyl CoA reductase activity|long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming)|long-chain fatty acyl-CoA reductase activity EC:1.2.1.50|MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN|RHEA:15437 molecular_function owl:Class
GO:0090674 biolink:NamedThing endothelial cell-matrix adhesion via fibronectin The binding of an endothelial cell to the extracellular matrix via fibronectin. got7fsn_ti tb 2016-01-15T15:40:58Z biological_process owl:Class
GO:0090673 biolink:NamedThing endothelial cell-matrix adhesion The binding of an endothelial cell to the extracellular matrix via adhesion molecules. got7fsn_ti tb 2016-01-15T15:38:11Z biological_process owl:Class
GO:0062150 biolink:NamedThing amorpha-4,11-diene 12-monooxygenase activity Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. got7fsn_ti dph 2019-09-13T14:48:12Z EC:1.14.14.114|RHEA:32999 molecular_function owl:Class
GO:0102330 biolink:NamedThing palmitoyl-[acp] elongase/decarboxylase activity Catalysis of the reaction: malonyl-CoA + a palmitoyl-[acp] = 1-heptadecene + 2 carbon dioxide + coenzyme A + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-13258 molecular_function owl:Class
GO:0050235 biolink:NamedThing pyridoxal 4-dehydrogenase activity Catalysis of the reaction: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH. got7fsn_ti pyridoxal dehydrogenase activity|pyridoxal:NAD+ 4-oxidoreductase activity MetaCyc:PYRIDOXAL-4-DEHYDROGENASE-RXN|KEGG_REACTION:R01707|EC:1.1.1.107|RHEA:21336 molecular_function owl:Class
GO:0097412 biolink:NamedThing hyaline inclusion A glass-like, pale intracellular inclusion. got7fsn_ti pale body pr 2012-11-06T16:24:58Z NIF_Subcellular:nlx_subcell_20090104 cellular_component owl:Class
GO:0047991 biolink:NamedThing hydroxylamine oxidase activity Catalysis of the reaction: hydroxylamine + O(2) = H(2)O + H(+) + nitrite. got7fsn_ti hydroxylamine:oxygen oxidoreductase activity|HAO|hydroxylamine oxidoreductase MetaCyc:HAONITRO-RXN|EC:1.7.3.6|RHEA:19969|KEGG_REACTION:R00793 molecular_function owl:Class
GO:0003992 biolink:NamedThing N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. got7fsn_ti acetylornithine transaminase activity|acetylornithine aminotransferase activity|N-acetylornithine-delta-transaminase activity|N2-acetylornithine 5-transaminase activity|succinylornithine aminotransferase activity|acetylornithine delta-transaminase activity|ACOAT activity|N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity|N-acetylornithine aminotransferase activity|acetylornithine 5-aminotransferase activity|N(2)-acetylornithine 5-transaminase activity|2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity|N2-acetylornithine 5-aminotransferase activity GO:0047318 MetaCyc:ACETYLORNTRANSAM-RXN|KEGG_REACTION:R02283|RHEA:18049|EC:2.6.1.11 molecular_function owl:Class
GO:0071741 biolink:NamedThing IgD immunoglobulin complex, GPI-anchored A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and bound via a GPI-anchor to the plasma membrane of B cells. got7fsn_ti GPI-anchored IgD Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available. mah 2010-03-24T01:44:53Z cellular_component owl:Class
GO:0031788 biolink:NamedThing motilin receptor binding Binding to a motilin receptor. got7fsn_ti motilin receptor ligand molecular_function owl:Class
GO:0008821 biolink:NamedThing crossover junction endodeoxyribonuclease activity Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). got7fsn_ti crossover junction endoribonuclease activity|endo X3|Hje endonuclease activity|endodeoxyribonuclease RUS activity|SpCCe1 holliday junction resolvase|endonuclease X3 activity|Endo X3 activity|resolving enzyme CCE1 activity|Holliday junction resolvase activity|RusA endonuclease activity|Holliday junction nuclease activity|endonuclease VII activity|RuvC endonuclease activity|Holliday junction-cleaving endonuclease activity|RusA Holliday junction resolvase activity|SpCCe1 Holliday junction resolvase activity|RusA holliday junction resolvase|Holliday junction-resolving endoribonuclease activity|Holliday junction endonuclease CCE1 activity|cruciform-cutting endonuclease activity|endonuclease RuvC activity GO:0008844 EC:3.1.22.4|MetaCyc:3.1.22.4-RXN molecular_function owl:Class
GO:0035941 biolink:NamedThing androstenedione secretion The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system. got7fsn_ti androst-4-ene-3,17-dione secretion bf 2011-07-25T02:11:47Z biological_process owl:Class
GO:0070709 biolink:NamedThing RNA guanosine insertion The modification of an RNA molecule by insertion of a guanosine nucleotide. got7fsn_ti RNA G insertion mah 2009-06-08T04:57:26Z biological_process owl:Class
GO:0047746 biolink:NamedThing chlorophyllase activity Catalysis of the reaction: chlorophyll + H2O = phytol + chlorophyllide. got7fsn_ti chlorophyll chlorophyllidohydrolase activity MetaCyc:CHLOROPHYLLASE-RXN|EC:3.1.1.14 molecular_function owl:Class
GO:0103027 biolink:NamedThing FMN phosphatase activity Catalysis of the reaction: FMN + H2O = riboflavin + hydrogenphosphate. got7fsn_ti MetaCyc:RXN0-5187 molecular_function owl:Class
GO:0036445 biolink:NamedThing neuronal stem cell division The self-renewing division of a neuronal stem cell. got7fsn_ti NSC division bf 2013-10-30T10:03:27Z biological_process owl:Class
GO:0048103 biolink:NamedThing somatic stem cell division The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line. got7fsn_ti somatic stem cell renewal biological_process owl:Class
GO:0008721 biolink:NamedThing D-serine ammonia-lyase activity Catalysis of the reaction: D-serine = pyruvate + NH3. got7fsn_ti D-serine deaminase activity|D-serine dehydratase activity|D-serine dehydration activity|D-serine dehydratase (deaminating) activity|D-serine ammonia-lyase (pyruvate-forming)|D-hydroxyaminoacid dehydratase activity|D-serine hydrolase activity|D-serine hydro-lyase (deaminating) activity|D-serine dehydrase activity|D-hydroxy amino acid dehydratase activity Note that this function was formerly EC:4.3.1.14. MetaCyc:DSERDEAM-RXN|Reactome:R-HSA-9034539|Reactome:R-HSA-9014741|RHEA:13977|EC:4.3.1.18 molecular_function owl:Class
GO:0072711 biolink:NamedThing cellular response to hydroxyurea Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus. got7fsn_ti cellular response to HU mah 2012-04-11T04:15:56Z biological_process owl:Class
GO:0103010 biolink:NamedThing gibberellin A53,2-oxoglutarate:oxygen oxidoreductase activity (GA97-forming) Catalysis of the reaction: gibberellin A53 + 2-oxoglutarate + O2 = gibberellin A97 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-991 molecular_function owl:Class
GO:0051109 biolink:NamedThing crotonobetaine-CoA ligase activity Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA. got7fsn_ti crotonobetaine-CoA synthase activity|crotonobetaine/carnitine-CoA ligase activity MetaCyc:CROTCOALIG-RXN|RHEA:30079 molecular_function owl:Class
GO:0051922 biolink:NamedThing cholesterol sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate. got7fsn_ti EC:2.8.2.- molecular_function owl:Class
GO:0002933 biolink:NamedThing lipid hydroxylation The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid. got7fsn_ti fatty acid hydroxylation hjd 2012-04-24T02:26:33Z biological_process owl:Class
GO:0008785 biolink:NamedThing alkyl hydroperoxide reductase activity Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol. got7fsn_ti UM-BBD_reactionID:r0684|Reactome:R-HSA-1222526 molecular_function owl:Class
GO:0051371 biolink:NamedThing muscle alpha-actinin binding Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. got7fsn_ti alpha-actinin 3 binding|alpha-actinin 2 binding molecular_function owl:Class
GO:0004572 biolink:NamedThing mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3). got7fsn_ti alpha-mannosidase II|mannosidase II activity|mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity|GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity|exo-1,3-1,6-alpha-mannosidase activity|Golgi alpha-mannosidase II|alpha-(1,3/6)-mannosidase activity|1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity|mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity|ManII activity|mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity|alpha-D-mannosidase II MetaCyc:3.2.1.114-RXN|RHEA:56052|EC:3.2.1.114|Reactome:R-HSA-975814 molecular_function owl:Class
GO:0006189 biolink:NamedThing 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. got7fsn_ti 'de novo' purine biosynthetic process|'de novo' IMP synthesis|'de novo' IMP biosynthesis|'de novo' purine biosynthesis|'de novo' IMP anabolism|'de novo' IMP formation biological_process owl:Class
GO:0043840 biolink:NamedThing branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine. got7fsn_ti branched-chain-amino-acid:2-keto-4-methylthiobutyrate aminotransferase activity|branched-chain amino acid aminotransferase|branched chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity|BCAT MetaCyc:RXN-7708 molecular_function owl:Class
GO:1990275 biolink:NamedThing preribosome binding Binding to a preribosome. got7fsn_ti tb 2014-01-16T19:14:50Z molecular_function owl:Class
GO:0089716 biolink:NamedThing Pip2-Oaf1 complex A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins. got7fsn_ti cellular_component owl:Class
GO:2000035 biolink:NamedThing regulation of stem cell division Any process that modulates the frequency, rate or extent of stem cell division. got7fsn_ti regulation of stem cell renewal tb 2010-08-05T11:34:53Z biological_process owl:Class
GO:0035154 biolink:NamedThing terminal cell fate specification, open tracheal system The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange. got7fsn_ti terminal cell fate specification biological_process owl:Class
GO:0047978 biolink:NamedThing hexadecanol dehydrogenase activity Catalysis of the reaction: hexadecanol + NAD+ = hexadecanal + NADH. got7fsn_ti hexadecanol:NAD+ oxidoreductase activity EC:1.1.1.164|MetaCyc:HEXADECANOL-DEHYDROGENASE-RXN|RHEA:22056 molecular_function owl:Class
GO:0042276 biolink:NamedThing error-prone translesion synthesis The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. got7fsn_ti error-prone postreplication DNA repair|mutagenic postreplication DNA repair|mutagenic PRR biological_process owl:Class
GO:0045820 biolink:NamedThing negative regulation of glycolytic process Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis. got7fsn_ti down-regulation of glycolysis|downregulation of glycolysis|inhibition of glycolysis|down regulation of glycolysis biological_process owl:Class
GO:0102935 biolink:NamedThing gypsogenin-UDP-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + gypsogenin = gypsogenin-28-beta-D-glucoside + UDP. got7fsn_ti MetaCyc:RXN-9012 molecular_function owl:Class
GO:0000806 biolink:NamedThing Y chromosome The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males. got7fsn_ti Wikipedia:Y_chromosome cellular_component owl:Class
GO:0050557 biolink:NamedThing deacetylipecoside synthase activity Catalysis of the reaction: deacetylipecoside + H(2)O = dopamine + secologanin. got7fsn_ti deacetylipecoside dopamine-lyase (secologanin-forming)|deacetylipecoside dopamine-lyase activity EC:4.3.3.4|KEGG_REACTION:R05749|RHEA:12296|MetaCyc:4.3.3.4-RXN molecular_function owl:Class
GO:0034314 biolink:NamedThing Arp2/3 complex-mediated actin nucleation The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. got7fsn_ti branched actin filament nucleation|actin filament branch nucleation biological_process owl:Class
GO:0006221 biolink:NamedThing pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti pyrimidine nucleotide formation|pyrimidine nucleotide synthesis|pyrimidine nucleotide biosynthesis|pyrimidine nucleotide anabolism biological_process owl:Class
GO:0052770 biolink:NamedThing coenzyme F390-A hydrolase activity Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420. got7fsn_ti 8-hydroxyadenylylated-coenzyme F420 hydrolase activity ai 2011-10-03T12:00:00Z molecular_function owl:Class
GO:1990281 biolink:NamedThing efflux pump complex A protein complex that is capable of efflux transmembrane transporter activity. got7fsn_ti efflux transmembrane transporter complex|efflux pump tt 2014-01-31T08:19:53Z cellular_component owl:Class
GO:0019716 biolink:NamedThing N-terminal peptidyl-alanine monomethylation The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine. got7fsn_ti RESID:AA0061 biological_process owl:Class
GO:0090475 biolink:NamedThing lys-lys specific dibasic protein processing Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein. got7fsn_ti tb 2012-10-01T10:42:30Z biological_process owl:Class
GO:0140572 biolink:NamedThing vacuole fission The division of a vacuole within a cell to form two or more separate vacuoles. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20639 pg 2021-01-04T10:17:58Z biological_process owl:Class
GO:0050551 biolink:NamedThing myrcene synthase activity Catalysis of the reaction: geranyl diphosphate = diphosphate + myrcene. got7fsn_ti geranyl-diphosphate diphosphate-lyase (myrcene-forming) activity KEGG_REACTION:R02009|RHEA:16965|MetaCyc:RXN-5110|EC:4.2.3.15 molecular_function owl:Class
GO:0010507 biolink:NamedThing negative regulation of autophagy Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. got7fsn_ti biological_process owl:Class
GO:0106046 biolink:NamedThing guanine deglycation, glyoxal removal The removal of glyoxal from a glycated guanine, to form glycolate and a deglycated guanine. got7fsn_ti hjd 2017-08-01T18:19:30Z biological_process owl:Class
GO:0046125 biolink:NamedThing pyrimidine deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). got7fsn_ti pyrimidine deoxyribonucleoside metabolism biological_process owl:Class
GO:0050033 biolink:NamedThing L-rhamnono-1,4-lactonase activity Catalysis of the reaction: L-rhamnono-1,4-lactone + H(2)O = L-rhamnonate + H(+). got7fsn_ti L-rhamnono-1,4-lactone lactonohydrolase activity|L-rhamnono-gamma-lactonase activity|L-rhamno-gamma-lactonase activity RHEA:10288|MetaCyc:L-RHAMNONO-14-LACTONASE-RXN|EC:3.1.1.65|KEGG_REACTION:R03772 molecular_function owl:Class
GO:0103028 biolink:NamedThing murein hydrolase activity Catalysis of the reaction: a peptidoglycan dimer (generic) = a lipid II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide. got7fsn_ti MetaCyc:RXN0-5190 molecular_function owl:Class
GO:0043453 biolink:NamedThing alkyne biosynthetic process The chemical reactions and pathways resulting in the formation of an alkyne, any acyclic branched or unbranched hydrocarbon (compound composed only of carbon and hydrogen) having a carbon-carbon triple bond and the general formula CnH2n-2. got7fsn_ti alkyne synthesis|alkyne formation|alkyne anabolism|alkyne biosynthesis biological_process owl:Class
GO:0006031 biolink:NamedThing chitin biosynthetic process The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. got7fsn_ti chitin biosynthesis|chitin formation|beta-1,4-linked N-acetylglucosamine biosynthetic process|chitin anabolism|beta-1,4-linked N-acetylglucosamine biosynthesis|chitin synthesis biological_process owl:Class
GO:0062204 biolink:NamedThing (13S)-vitexifolin A synthase activity Catalysis of the reaction:9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate. got7fsn_ti dph 2020-01-03T13:24:50Z RHEA:40027 molecular_function owl:Class
GO:0047370 biolink:NamedThing succinate-citramalate CoA-transferase activity Catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate. got7fsn_ti succinyl coenzyme A-citramalyl coenzyme A transferase activity|succinyl-CoA:citramalate CoA-transferase activity|citramalate coenzyme A-transferase activity|itaconate CoA-transferase activity MetaCyc:2.8.3.7-RXN|RHEA:23528 molecular_function owl:Class
GO:0032610 biolink:NamedThing interleukin-1 alpha production The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti interleukin-1 alpha biosynthetic process|IL-1 alpha production|interleukin-1 alpha secretion GO:0050703|GO:0050719 biological_process owl:Class
GO:0060764 biolink:NamedThing cell-cell signaling involved in mammary gland development Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure. got7fsn_ti cell-cell signalling involved in mammary gland development dph 2009-07-06T09:24:53Z biological_process owl:Class
GO:0031537 biolink:NamedThing regulation of anthocyanin metabolic process Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins. got7fsn_ti regulation of anthocyanin metabolism biological_process owl:Class
GO:1990402 biolink:NamedThing embryonic liver development The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure. got7fsn_ti sl 2014-06-23T20:52:03Z biological_process owl:Class
GO:0047543 biolink:NamedThing 2-hexadecenal reductase activity Catalysis of the reaction: NADP(+) + palmitaldehyde = trans-hexadec-2-enal + H(+) + NADPH. got7fsn_ti hexadecanal:NADP+ delta2-oxidoreductase activity|hexadecanal: NADP+ oxidoreductase activity EC:1.3.1.27|KEGG_REACTION:R02463|MetaCyc:2-HEXADECENAL-REDUCTASE-RXN|RHEA:12444 molecular_function owl:Class
GO:0046173 biolink:NamedThing polyol biosynthetic process The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. got7fsn_ti polyhydric alcohol biosynthetic process|polyol synthesis|polyol anabolism|polyol formation|polyol biosynthesis biological_process owl:Class
GO:0031643 biolink:NamedThing positive regulation of myelination Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons. got7fsn_ti up-regulation of myelination|stimulation of myelination|upregulation of myelination|up regulation of myelination|activation of myelination biological_process owl:Class
GO:0102691 biolink:NamedThing UDP-glucose:benzyladenine 7-N-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + N-benzyladenine <=> H+ + benzyladenine-7-N-glucoside + UDP. got7fsn_ti MetaCyc:RXN-4729 molecular_function owl:Class
GO:0098848 biolink:NamedThing alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity Catalysis of the reaction: alpha-D-ribose 1-methylphosphonate 5-phosphate = alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane. got7fsn_ti alpha-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane forming) RHEA:34707|EC:4.7.1.1 molecular_function owl:Class
GO:0019917 biolink:NamedThing peptidyl-D-alanine racemization via peptidyl-L-serine The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine. got7fsn_ti RESID:AA0191 biological_process owl:Class
GO:0019399 biolink:NamedThing cyclohexanol oxidation The cyclohexanol metabolic process in which cyclohexanol is converted to adipate. got7fsn_ti MetaCyc:CYCLOHEXANOL-OXIDATION-PWY biological_process owl:Class
GO:0050231 biolink:NamedThing putrescine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H(+) + phosphate. got7fsn_ti carbamoyl-phosphate:putrescine carbamoyltransferase activity|putrescine synthase activity|putrescine transcarbamylase activity|PTCase activity MetaCyc:PUTRESCINE-CARBAMOYLTRANSFERASE-RXN|RHEA:21936|EC:2.1.3.6|KEGG_REACTION:R01399 molecular_function owl:Class
GO:0052806 biolink:NamedThing sulfite reductase (coenzyme F420) activity Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420. got7fsn_ti hydrogen-sulfide:coenzyme F420 oxidoreductase activity|coenzyme F420-sulfite reductase activity|coenzyme F420-dependent sulfite reductase activity|sulfite:reduced coenzyme F420 reductase activity ai 2011-09-22T04:08:13Z molecular_function owl:Class
GO:0047544 biolink:NamedThing 2-hydroxybiphenyl 3-monooxygenase activity Catalysis of the reaction: biphenyl-2-ol + H(+) + NADH + O(2) = biphenyl-2,3-diol + H(2)O + NAD(+). got7fsn_ti 2-hydroxybiphenyl,NADH:oxygen oxidoreductase (3-hydroxylating) RHEA:11996|KEGG_REACTION:R03964|MetaCyc:2-HYDROXYBIPHENYL-3-MONOOXYGENASE-RXN|UM-BBD_reactionID:r1423|EC:1.14.13.44 molecular_function owl:Class
GO:0034895 biolink:NamedThing pyridine-3,4-diol dioxygenase activity Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate. got7fsn_ti EC:1.13.11.-|UM-BBD_reactionID:r1398 molecular_function owl:Class
GO:0051169 biolink:NamedThing nuclear transport The directed movement of substances into, out of, or within the nucleus. got7fsn_ti nucleus transport Wikipedia:Nuclear_transport biological_process owl:Class
GO:0043392 biolink:NamedThing negative regulation of DNA binding Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). got7fsn_ti down-regulation of DNA binding|downregulation of DNA binding|inhibition of DNA binding|down regulation of DNA binding biological_process owl:Class
GO:0033905 biolink:NamedThing xylan endo-1,3-beta-xylosidase activity Catalysis of the random hydrolysis of (1->3)-beta-D-glycosidic linkages in (1->3)-beta-D-xylans. got7fsn_ti 1,3-beta-xylanase activity|endo-1,3-beta-xylanase activity|1,3-beta-D-xylan xylanohydrolase activity|endo-1,3-xylanase activity|xylanase activity|beta-1,3-xylanase activity|endo-beta-1,3-xylanase activity|1,3-xylanase activity MetaCyc:3.2.1.32-RXN|EC:3.2.1.32 molecular_function owl:Class
GO:0003833 biolink:NamedThing beta-alanyl-dopamine synthase activity Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine). got7fsn_ti N-beta-alanyl dopamine synthetase activity|NBAD transferase activity molecular_function owl:Class
GO:0042444 biolink:NamedThing phenylethylamine biosynthetic process The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds. got7fsn_ti phenylethylamine anabolism|phenylethylamine formation|phenylethylamine biosynthesis|phenylethylamine synthesis biological_process owl:Class
GO:0047190 biolink:NamedThing 2-acylglycerophosphocholine O-acyltransferase activity Catalysis of the reaction: 2-acyl-sn-glycero-3-phosphocholine + acyl-CoA = 1,2-diacyl-sn-glycero-3-phosphocholine + CoA. got7fsn_ti acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase activity|2-acylglycerol-3-phosphorylcholine acyltransferase activity|2-acylglycerophosphocholine acyltransferase activity MetaCyc:2.3.1.62-RXN|EC:2.3.1.62|RHEA:10332|KEGG_REACTION:R01319 molecular_function owl:Class
GO:0009120 biolink:NamedThing deoxyribonucleoside metabolic process The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside). got7fsn_ti deoxyribonucleoside metabolism biological_process owl:Class
GO:0047810 biolink:NamedThing D-alanine:2-oxoglutarate aminotransferase activity Catalysis of the reaction: D-alanine + 2-oxoglutarate = pyruvate + D-glutamate. got7fsn_ti D-aspartate transaminase activity|D-amino acid transaminase activity|D-alanine-D-glutamate transaminase activity|D-amino acid aminotransferase activity|D-alanine aminotransferase activity|D-aspartate aminotransferase activity|D-aspartic aminotransferase activity|D-alanine transaminase activity|D-amino-acid transaminase activity EC:2.6.1.21|RHEA:15869|MetaCyc:D-ALANINE-AMINOTRANSFERASE-RXN molecular_function owl:Class
GO:0034285 biolink:NamedThing response to disaccharide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disaccharide stimulus. got7fsn_ti response to disaccharide stimulus biological_process owl:Class
GO:0036134 biolink:NamedThing 12-hydroxyheptadecatrienoic acid synthase activity Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA). got7fsn_ti prostaglandin H2 degradation activity bf 2012-03-05T11:17:34Z RHEA:48644|Reactome:R-HSA-2161613 molecular_function owl:Class
GO:0045522 biolink:NamedThing interleukin-26 receptor binding Binding to an interleukin-26 receptor. got7fsn_ti IL-26|interleukin-26 receptor ligand molecular_function owl:Class
GO:0008674 biolink:NamedThing 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate. got7fsn_ti 2-keto-3-deoxy-6-phosphogalactonic aldolase activity|2-dehydro-3-deoxyphosphogalactonate aldolase activity|2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity|2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity|2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)|phospho-2-keto-3-deoxygalactonate aldolase activity|(KDPGal)aldolase activity|2-oxo-3-deoxygalactonate 6-phosphate aldolase activity|6-phospho-2-dehydro-3-deoxygalactonate aldolase activity|6-phospho-2-keto-3-deoxygalactonate aldolase activity|phospho-2-keto-3-deoxygalactonic aldolase activity KEGG_REACTION:R01064|EC:4.1.2.21|MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN|RHEA:24464 molecular_function owl:Class
GO:0070682 biolink:NamedThing proteasome regulatory particle assembly The aggregation, arrangement and bonding together of a mature, active proteasome regulatory particle complex. got7fsn_ti proteasome regulatory complex assembly mah 2009-06-02T03:46:29Z biological_process owl:Class
GO:0072357 biolink:NamedThing PTW/PP1 phosphatase complex A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. got7fsn_ti mah 2010-11-15T03:32:27Z cellular_component owl:Class
GO:0034058 biolink:NamedThing endosomal vesicle fusion The homotypic fusion of endocytic vesicles to form or add to an early endosome. got7fsn_ti endosome vesicle fusion biological_process owl:Class
GO:0097723 biolink:NamedThing amoeboid sperm motility Any process involved in the controlled movement of an amoeboid sperm cell. got7fsn_ti ameboid sperm motility|amoeboid sperm movement|ameboid sperm movement pr 2016-09-01T12:02:19Z biological_process owl:Class
GO:0070613 biolink:NamedThing regulation of protein processing Any process that modulates the frequency, rate or extent of protein processing, a protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. got7fsn_ti regulation of protein maturation by peptide bond cleavage mah 2009-04-29T02:49:14Z GO:0010953 biological_process owl:Class
GO:0070839 biolink:NamedThing metal ion export The directed movement of metal cations, out of a cell or organelle. got7fsn_ti divalent metal ion export mah 2009-07-31T01:07:46Z biological_process owl:Class
GO:0005827 biolink:NamedThing polar microtubule Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart. got7fsn_ti pole-to-pole microtubule cellular_component owl:Class
GO:0016036 biolink:NamedThing cellular response to phosphate starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. got7fsn_ti biological_process owl:Class
GO:0047968 biolink:NamedThing glyoxylate dehydrogenase (acylating) activity Catalysis of the reaction: CoA + glyoxylate + NADP(+) = H(+) + NADPH + oxalyl-CoA. got7fsn_ti glyoxylate:NADP+ oxidoreductase (CoA-oxalylating) MetaCyc:GLYOXYLATE-DEHYDROGENASE-ACYLATING-RXN|KEGG_REACTION:R00468|RHEA:21024|EC:1.2.1.17 molecular_function owl:Class
GO:0070966 biolink:NamedThing nuclear-transcribed mRNA catabolic process, no-go decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA with stalls in translation elongation. got7fsn_ti nuclear-transcribed mRNA breakdown, no-go decay|nuclear-transcribed mRNA degradation, no-go decay|nuclear-transcribed mRNA catabolism, no-go decay|no-go decay|no-go mRNA decay mah 2009-10-01T02:36:22Z biological_process owl:Class
GO:0106329 biolink:NamedThing L-phenylalaine oxidase activity Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+). got7fsn_ti hjd 2020-09-30T19:33:52Z RHEA:61240 molecular_function owl:Class
GO:0000372 biolink:NamedThing Group I intron splicing The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize). got7fsn_ti mRNA splicing Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone). biological_process owl:Class
GO:0039698 biolink:NamedThing polyadenylation of viral mRNA by polymerase stuttering Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail. got7fsn_ti polyA stuttering bf 2013-10-28T14:54:07Z VZ:1916 biological_process owl:Class
GO:0047050 biolink:NamedThing (S)-2-hydroxy-fatty acid dehydrogenase activity Catalysis of the reaction: (S)-2-hydroxystearate + NAD(+) = 2-oxostearate + H(+) + NADH. got7fsn_ti dehydrogenase, L-2-hydroxy fatty acid|(S)-2-hydroxy-fatty-acid dehydrogenase activity|L-2-hydroxy fatty acid dehydrogenase activity|(S)-2-hydroxystearate:NAD+ oxidoreductase activity|2-hydroxy fatty acid oxidase MetaCyc:1.1.1.99-RXN|RHEA:11384|EC:1.1.1.99|KEGG_REACTION:R03022 molecular_function owl:Class
GO:0004157 biolink:NamedThing dihydropyrimidinase activity Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate. got7fsn_ti hydantoin peptidase activity|D-hydantoinase activity|5,6-dihydropyrimidine amidohydrolase activity|pyrimidine hydrase activity|hydantoinase activity|hydropyrimidine hydrase activity MetaCyc:DIHYDROPYRIMIDINASE-RXN|EC:3.5.2.2|Reactome:R-HSA-73589|Reactome:R-HSA-73618|RHEA:16121 molecular_function owl:Class
GO:0140449 biolink:NamedThing centromere-nuclear envelope anchor activity The binding activity of a molecule that brings together the centromeric region of a chromosome and the inner nuclear membrane by interacting with both the centromere/kinetochore complex and the nuclear membrane, in order to establish and maintain the centromere/kinetochore location. got7fsn_ti centromere-inner nuclear envelope anchor activity|nuclear envelope-centromere tether activity|centromere nuclear envelope anchor activity|nuclear envelope-centromere anchor activity|centromere-inner nuclear envelope tether activity|centromere nuclear envelope tether activity|chromosome, centromeric region-nuclear envelope anchor activity https://github.com/geneontology/go-ontology/issues/19227 pg 2020-04-07T06:27:08Z molecular_function owl:Class
GO:0031765 biolink:NamedThing type 2 galanin receptor binding Binding to a type 2 galanin receptor. got7fsn_ti type 2 galanin receptor ligand molecular_function owl:Class
GO:0001154 biolink:NamedThing TFIIIB-class transcription factor complex binding Binding to a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III. got7fsn_ti TFIIIB-class transcription factor binding krc 2011-01-27T04:53:50Z molecular_function owl:Class
GO:0034900 biolink:NamedThing 3-(N-formyl)-formiminopyruvate hydrolase activity Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate. got7fsn_ti EC:3.5.99.-|UM-BBD_reactionID:r1399 molecular_function owl:Class
GO:0047108 biolink:NamedThing (R)-3-hydroxyacid-ester dehydrogenase activity Catalysis of the reaction: ethyl (R)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + H(+) + NADPH. got7fsn_ti (R)-3-hydroxyacid ester dehydrogenase activity|3-oxo ester (R)-reductase activity|ethyl-(R)-3-hydroxyhexanoate:NADP+ 3-oxidoreductase activity Note that this term was EC:1.2.1.55. EC:1.1.1.279|KEGG_REACTION:R04105|MetaCyc:1.2.1.55-RXN|RHEA:24352 molecular_function owl:Class
GO:0055016 biolink:NamedThing hypochord development The process whose specific outcome is the progression of the hypochord over time, from its formation to the mature structure. The hypochord is a transient rod-like structure in the embryos of fish, lampreys and amphibians that is located immediately ventral to the notochord. The hypochord may play a role in positioning the dorsal aorta. got7fsn_ti subnotochordal rod development biological_process owl:Class
GO:0070182 biolink:NamedThing DNA polymerase binding Binding to a DNA polymerase. got7fsn_ti molecular_function owl:Class
GO:1900968 biolink:NamedThing regulation of sarcinapterin metabolic process Any process that modulates the frequency, rate or extent of sarcinapterin metabolic process. got7fsn_ti regulation of sarcinapterin metabolism tt 2012-06-14T03:58:11Z biological_process owl:Class
GO:0032251 biolink:NamedThing positive regulation of adenosine transport Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti up-regulation of adenosine transport|stimulation of adenosine transport|activation of adenosine transport|up regulation of adenosine transport|upregulation of adenosine transport biological_process owl:Class
GO:0009822 biolink:NamedThing alkaloid catabolic process The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). got7fsn_ti alkaloid degradation|alkaloid breakdown|alkaloid catabolism biological_process owl:Class
GO:0061676 biolink:NamedThing importin-alpha family protein binding Binding to a member of the importin-alpha family. got7fsn_ti dph 2015-01-10T18:25:22Z molecular_function owl:Class
GO:0050241 biolink:NamedThing pyrroline-2-carboxylate reductase activity Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+. got7fsn_ti L-proline:NAD(P)+ 2-oxidoreductase activity|delta1-pyrroline-2-carboxylate reductase activity MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN|EC:1.5.1.1 molecular_function owl:Class
GO:0044272 biolink:NamedThing sulfur compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. got7fsn_ti sulfur compound formation|sulfur compound biosynthesis|sulfur compound synthesis|sulfur biosynthetic process|sulfur compound anabolism|sulfur biosynthesis biological_process owl:Class
GO:0046593 biolink:NamedThing mandelonitrile lyase activity Catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde. got7fsn_ti D-oxynitrilase activity|(R)-oxynitrilase activity|mandelonitrile benzaldehyde-lyase activity|hydroxynitrile lyase activity|mandelonitrile benzaldehyde-lyase (cyanide-forming)|D-alpha-hydroxynitrile lyase activity RHEA:18313|EC:4.1.2.10|MetaCyc:MANDELONITRILE-LYASE-RXN molecular_function owl:Class
GO:0106231 biolink:NamedThing protein-propionyllysine depropionylase activity Catalysis of the reaction:H2O + N(6)-propanoyl-L-lysyl-[protein] + NAD(+) = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide. got7fsn_ti This reaction is the removal of a propionyl group from a propionylated lysine residue of a protein or peptide. hjd 2019-10-18T14:14:47Z RHEA:23500 molecular_function owl:Class
GO:0044218 biolink:NamedThing other organism cell membrane The cell membrane of a secondary organism with which the first organism is interacting. got7fsn_ti other organism membrane|foreign membrane jl 2009-11-12T02:37:44Z GO:0044279 cellular_component owl:Class
GO:0047032 biolink:NamedThing 3-alpha-hydroxyglycyrrhetinate dehydrogenase activity Catalysis of the reaction: 3alpha-hydroxyglycyrrhetinate + NADP(+) = 3-oxoglycyrrhetinate + H(+) + NADPH. got7fsn_ti 3alpha-hydroxyglycyrrhetinate dehydrogenase activity|3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase activity RHEA:20816|KEGG_REACTION:R04099|EC:1.1.1.230|MetaCyc:1.1.1.230-RXN molecular_function owl:Class
GO:0036515 biolink:NamedThing serotonergic neuron axon guidance The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues. got7fsn_ti 5-HT axon guidance|serotonergic axon guidance bf 2015-12-17T11:15:54Z biological_process owl:Class
GO:0045294 biolink:NamedThing alpha-catenin binding Binding to catenin complex alpha subunit. got7fsn_ti molecular_function owl:Class
GO:0071060 biolink:NamedThing alpha7-beta1 integrin-CD151 complex A protein complex that consists of an alpha7-beta1 integrin complex bound to the tetraspanin CD151. got7fsn_ti ITGA7-ITGB1-CD151 complex mah 2009-11-03T04:02:01Z cellular_component owl:Class
GO:0140107 biolink:NamedThing high-affinity potassium ion transmembrane transporter activity Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti pg 2017-10-12T09:54:39Z molecular_function owl:Class
GO:0052599 biolink:NamedThing methylputrescine oxidase activity Catalysis of the reaction: N-methylputrescine + H2O + O2 = N-methylaminobutanal + NH3 + hydrogen peroxide + H+. got7fsn_ti N-methylputrescine:oxygen oxidoreductase (deaminating) activity EC:1.4.3.22|KEGG_REACTION:R05334|MetaCyc:RXN-8244 molecular_function owl:Class
GO:0140033 biolink:NamedThing acetylation-dependent protein binding Binding to a protein upon acetylation of the target protein. got7fsn_ti This term should only be used when the binding is shown to require acetylation of the target protein: the interaction needs to be tested with and without the PTM. The binding does not need to be at the site of acetylation. It may be that the acetylation causes a conformational change that allows binding of the protein to another region; this type of acetylation-dependent protein binding is valid for annotation to this term. pg 2017-05-17T15:35:43Z molecular_function owl:Class
GO:0050246 biolink:NamedThing questin monooxygenase activity Catalysis of the reaction: H(+) + NADPH + O(2) + questin = demethylsulochrin + NADP(+). got7fsn_ti questin,NADPH:oxygen oxidoreductase (hydroxylating, anthraquinone-ring-opening)|questin oxygenase activity MetaCyc:QUESTIN-MONOOXYGENASE-RXN|KEGG_REACTION:R02417|RHEA:10836|EC:1.14.13.43 molecular_function owl:Class
GO:0097304 biolink:NamedThing lipoprotein biosynthetic process via signal peptide cleavage The chemical reactions and pathways by which signal peptide cleavage leads to formation of a water-soluble protein-lipid complex. got7fsn_ti lipoprotein biosynthesis (signal peptide cleavage) pr 2012-05-15T01:05:17Z biological_process owl:Class
GO:0005005 biolink:NamedThing transmembrane-ephrin receptor activity Combining with a transmembrane ephrin to initiate a change in cell activity. got7fsn_ti transmembrane-Eph receptor activity molecular_function owl:Class
GO:0036200 biolink:NamedThing 3-ketosteroid 9-alpha-monooxygenase activity Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O. got7fsn_ti 3-ketosteroid 9alpha-hydroxylase activity|KshAB activity bf 2012-04-20T02:09:47Z EC:1.14.15.30|RHEA:32199|KEGG_REACTION:R09860 molecular_function owl:Class
GO:0042216 biolink:NamedThing phenanthrene catabolic process The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon. got7fsn_ti phenanthrene catabolism|phenanthrene degradation|phenanthrene breakdown UM-BBD_pathwayID:phe biological_process owl:Class
GO:0102177 biolink:NamedThing 24-methylenelophenol methyl oxidase activity Catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O. got7fsn_ti RHEA:58872|MetaCyc:RXN-11930 molecular_function owl:Class
GO:0033987 biolink:NamedThing 2-hydroxyisoflavanone dehydratase activity Catalysis of the reaction: 2,7,4'-trihydroxyisoflavanone = daidzein + H2O. got7fsn_ti 2,7,4'-trihydroxyisoflavanone hydro-lyase activity|2,7,4'-trihydroxyisoflavanone hydro-lyase (daidzein-forming) activity EC:4.2.1.105|MetaCyc:RXN-3284|RHEA:16445 molecular_function owl:Class
GO:0035387 biolink:NamedThing negative regulation of Roundabout signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway. got7fsn_ti negative regulation of Roundabout signalling pathway bf 2010-03-18T02:40:00Z biological_process owl:Class
GO:0061624 biolink:NamedThing fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate. got7fsn_ti dph 2014-04-29T12:58:28Z biological_process owl:Class
GO:0051520 biolink:NamedThing termination of bipolar cell growth Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell. got7fsn_ti biological_process owl:Class
GO:0051517 biolink:NamedThing negative regulation of bipolar cell growth Any process that stops, prevents, or reduces the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell. got7fsn_ti down-regulation of bipolar cell growth|downregulation of bipolar cell growth|inhibition of bipolar cell growth|down regulation of bipolar cell growth biological_process owl:Class
GO:0102991 biolink:NamedThing myristoyl-CoA hydrolase activity Catalysis of the reaction: myristoyl-CoA + H2O <=> H+ + tetradecanoate + coenzyme A. got7fsn_ti RHEA:40119|EC:3.1.2.2|MetaCyc:RXN-9626 molecular_function owl:Class
GO:0031818 biolink:NamedThing P2Y9 nucleotide receptor binding Binding to a P2Y9 nucleotide receptor. got7fsn_ti P2Y9 nucleotide receptor ligand molecular_function owl:Class
GO:0031591 biolink:NamedThing wybutosine biosynthetic process The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules. got7fsn_ti yW biosynthesis|yW biosynthetic process Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe. biological_process owl:Class
GO:0031627 biolink:NamedThing telomeric loop formation The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region. got7fsn_ti t-loop biosynthesis|T loop biosynthesis|T loop formation|t-loop formation biological_process owl:Class
GO:0052787 biolink:NamedThing alpha-linked polysaccharide catabolism to maltopentaose The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltopentaose. got7fsn_ti maltopentaose-forming alpha-amylase activity|alpha-amylase-mediated polysaccharide catabolism, producing maltopentaose ai 2011-10-04T10:06:44Z biological_process owl:Class
GO:0102993 biolink:NamedThing linolenate delta15 desaturase activity Catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-9667|RHEA:46408 molecular_function owl:Class
GO:0071679 biolink:NamedThing commissural neuron axon guidance The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues. got7fsn_ti commissural neuron axon pathfinding mah 2010-02-17T02:21:36Z biological_process owl:Class
GO:0047948 biolink:NamedThing glutarate-CoA ligase activity Catalysis of the reaction: ATP + CoA + glutarate = ADP + glutaryl-CoA + H(+) + phosphate. got7fsn_ti glutaryl coenzyme A synthetase activity|glutaryl-CoA synthetase activity|glutarate:CoA ligase (ADP-forming) RHEA:14169|MetaCyc:GLUTARATE--COA-LIGASE-RXN|EC:6.2.1.6|KEGG_REACTION:R02402 molecular_function owl:Class
GO:0034731 biolink:NamedThing Lsm-containing SMN-Sm protein complex An SMN-Sm protein complex formed by the association of the methylated Sm proteins B/B', D3, E, F, and G, and Lsm10 and Lsm11, with the SMN complex. This complex forms Sm cores on U7 snRNA. got7fsn_ti SMN-containing protein complex cellular_component owl:Class
GO:0102324 biolink:NamedThing 2-hydroxy-6-oxo-nona-2,4-dienoate hydrolase activity Catalysis of the reaction: 2-hydroxy-6-oxo-nona-2,4-dienoate + H2O = butyrate + 2-oxopent-4-enoate + H+. got7fsn_ti MetaCyc:RXN-13157 molecular_function owl:Class
GO:0120327 biolink:NamedThing telopode A telopode is a plasma membrane bounded cell projection that is present on a telocyte and is tens to hundreds of microns long. Telopodes form a labyrinthine system communicating through gap junctions. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21973 krc 2021-08-16T16:45:21Z cellular_component owl:Class
GO:0036184 biolink:NamedThing asperthecin biosynthetic process The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans. got7fsn_ti asperthecin synthesis|asperthecin biosynthesis|asperthecin formation bf 2012-04-16T11:36:56Z biological_process owl:Class
GO:0035368 biolink:NamedThing selenocysteine insertion sequence binding Binding to a selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation. got7fsn_ti SECIS binding bf 2010-03-11T10:42:28Z molecular_function owl:Class
GO:0140439 biolink:NamedThing protein-cysteine S-stearoyltransferase activity Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]. got7fsn_ti https://github.com/geneontology/go-ontology/issues/18882 pg 2020-03-11T09:55:48Z RHEA:59740 molecular_function owl:Class
GO:0043754 biolink:NamedThing dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine. got7fsn_ti 2-methylpropanoyl-CoA:enzyme-N6-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity|enzyme-dihydrolipoyllysine:2-methylpropanoyl-CoA S-(2-methylpropanoyl)transferase activity|dihydrolipoyl transacylase activity|2-methylpropanoyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine:S-(2-methylpropanoyl)transferase activity MetaCyc:2.3.1.168-RXN|RHEA:18865|EC:2.3.1.168 molecular_function owl:Class
GO:0099621 biolink:NamedThing undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity Catalysis of the reaction: UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + ditrans,octacis-undecaprenyl phosphate = UDP + 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate. got7fsn_ti Ara4FN transferase activity|undecaprenyl phosphate-L-Ara4FN transferase activity|undecaprenyl-phosphate Ara4FN transferase activity GO:0103019 MetaCyc:RXN0-3521|EC:2.4.2.53|RHEA:27722 molecular_function owl:Class
GO:0035460 biolink:NamedThing L-ascorbate 6-phosphate lactonase activity Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate. got7fsn_ti bf 2010-04-16T02:05:41Z RHEA:28803 molecular_function owl:Class
GO:0019074 biolink:NamedThing viral RNA genome packaging The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid. got7fsn_ti biological_process owl:Class
GO:0002178 biolink:NamedThing palmitoyltransferase complex A protein complex with palmitoyltransferase activity. got7fsn_ti hjd 2010-12-03T10:49:17Z cellular_component owl:Class
GO:0036073 biolink:NamedThing perichondral ossification Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage. got7fsn_ti bf 2011-12-19T01:49:38Z biological_process owl:Class
GO:0071434 biolink:NamedThing cell chemotaxis to angiotensin The directed movement of a motile cell in response to the presence of angiotensin. got7fsn_ti angiotensin mediated chemotaxis|angiotensin-mediated cell chemotaxis mah 2009-12-16T11:07:15Z biological_process owl:Class
GO:0048246 biolink:NamedThing macrophage chemotaxis The movement of a macrophage in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0047278 biolink:NamedThing bilirubin-glucuronoside glucuronosyltransferase activity Catalysis of the reaction: 2 bilirubin-glucuronoside = bilirubin + bilirubin-bisglucuronoside. got7fsn_ti bilirubin-glucuronoside:bilirubin-glucuronoside D-glucuronosyltransferase activity|bilirubin monoglucuronide transglucuronidase activity|bilirubin glucuronoside glucuronosyltransferase activity KEGG_REACTION:R00062|RHEA:16885|MetaCyc:2.4.1.95-RXN molecular_function owl:Class
GO:1900599 biolink:NamedThing demethylkotanin biosynthetic process The chemical reactions and pathways resulting in the formation of demethylkotanin. got7fsn_ti demethylkotanin anabolism|demethylkotanin formation|demethylkotanin biosynthesis|demethylkotanin synthesis di 2012-05-15T06:55:21Z biological_process owl:Class
GO:0097046 biolink:NamedThing replication fork progression beyond termination site Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks. got7fsn_ti pr 2011-05-03T03:34:01Z biological_process owl:Class
GO:0010844 biolink:NamedThing recombination hotspot binding Binding to a genomic region which promotes recombination. got7fsn_ti DNA binding, recombination hotspot molecular_function owl:Class
GO:1990594 biolink:NamedThing L-altrarate dehydratase activity Catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O. got7fsn_ti L-talarate dehydratase activity jl 2014-12-16T14:23:55Z RHEA:44028 molecular_function owl:Class
GO:0102542 biolink:NamedThing aclacinomycin A methylesterase activity Catalysis of the reaction: aclacinomycin A + H2O <=> 15-demethoxy-aclacinomycin A + methanol + H+. got7fsn_ti EC:3.1.1.95|MetaCyc:RXN-14863 molecular_function owl:Class
GO:0033429 biolink:NamedThing CGU codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CGU codon. got7fsn_ti CGT codon-amino acid adaptor activity|arginine tRNA Note that in the standard genetic code, CGT codes for arginine. molecular_function owl:Class
GO:1905170 biolink:NamedThing negative regulation of protein localization to phagocytic vesicle Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to phagocytic vesicle. got7fsn_ti inhibition of protein recruitment to phagosome|negative regulation of protein localization in phagocytic vesicle|down regulation of protein localization to phagocytic vesicle|down-regulation of protein localisation to phagosome|down regulation of protein localisation to phagocytic vesicle|negative regulation of protein recruitment to phagosome|negative regulation of protein localisation to phagosome|down-regulation of protein recruitment to phagosome|inhibition of protein localisation to phagocytic vesicle|downregulation of protein recruitment to phagosome|down regulation of protein recruitment to phagosome|inhibition of protein localization in phagocytic vesicle|downregulation of protein localisation to phagocytic vesicle|downregulation of protein localization in phagocytic vesicle|inhibition of protein localisation in phagocytic vesicle|inhibition of protein localisation to phagosome|down-regulation of protein localisation in phagocytic vesicle|downregulation of protein localization to phagocytic vesicle|down regulation of protein localization in phagocytic vesicle|down-regulation of protein localization to phagocytic vesicle|down-regulation of protein localization in phagocytic vesicle|down regulation of protein localisation to phagosome|negative regulation of protein localisation in phagocytic vesicle|down regulation of protein localisation in phagocytic vesicle|negative regulation of protein localisation to phagocytic vesicle|downregulation of protein localisation in phagocytic vesicle|inhibition of protein localization to phagocytic vesicle|downregulation of protein localisation to phagosome|down-regulation of protein localisation to phagocytic vesicle bf 2016-05-02T18:38:22Z biological_process owl:Class
GO:0060834 biolink:NamedThing oral/aboral axis specification The establishment, maintenance and elaboration of a line that delineates the mouth and the anus of an embryo. got7fsn_ti oral/aboral axis determination dph 2009-08-11T03:25:26Z biological_process owl:Class
GO:0031934 biolink:NamedThing mating-type region heterochromatin Heterochromatic regions of the chromosome found at silenced mating-type loci. got7fsn_ti cellular_component owl:Class
GO:0034541 biolink:NamedThing dimethylarsinite methyltransferase activity Catalysis of the reaction: dimethylarsenous acid + R2S-CH3 = trimethylarsine oxide + R2SH. got7fsn_ti UM-BBD_reactionID:r0806 molecular_function owl:Class
GO:0071575 biolink:NamedThing integral component of external side of plasma membrane The component of the plasma membrane consisting of the gene products that penetrate only the external side of the membrane. got7fsn_ti integral to external side of plasma membrane|integral to external leaflet of plasma membrane mah 2010-01-26T05:20:28Z cellular_component owl:Class
GO:0102750 biolink:NamedThing tetrahydrogeranylgeranyl-chlorophyll a reductase activity Catalysis of the reaction: chlorophyll a + NADP = tetrahydrogeranylgeranyl-chlorophyll a + NADPH + H+. got7fsn_ti MetaCyc:RXN-7666 molecular_function owl:Class
GO:0001899 biolink:NamedThing negative regulation of cytolysis by symbiont of host cells Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative regulation by symbiont of cytolysis of host cells|down regulation by symbiont of cytolysis of host cells|inhibition by symbiont of cytolysis of host cells|down-regulation by symbiont of cytolysis of host cells|downregulation by symbiont of cytolysis of host cells biological_process owl:Class
GO:0042360 biolink:NamedThing vitamin E metabolic process The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant. got7fsn_ti tocopherol metabolism|alpha-tocopherol metabolic process|vitamin E metabolism|tocopherol metabolic process|alpha-tocopherol metabolism biological_process owl:Class
GO:1901593 biolink:NamedThing response to GW 7647 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus. got7fsn_ti mah 2012-11-07T17:16:48Z biological_process owl:Class
GO:0047877 biolink:NamedThing ephedrine dehydrogenase activity Catalysis of the reaction: (1R,2S)-ephedrine + NAD(+) = (R)-2-methylimino-1-phenylpropan-1-ol + 2 H(+) + NADH. got7fsn_ti (-)-ephedrine:NAD+ 2-oxidoreductase activity EC:1.5.1.18|MetaCyc:EPHEDRINE-DEHYDROGENASE-RXN|KEGG_REACTION:R03614|RHEA:16289 molecular_function owl:Class
GO:0050209 biolink:NamedThing polyvinyl-alcohol oxidase activity Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2. got7fsn_ti polyvinyl-alcohol:oxygen oxidoreductase activity|PVA oxidase activity|dehydrogenase, polyvinyl alcohol RHEA:21688|EC:1.1.3.30|MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN molecular_function owl:Class
GO:0061761 biolink:NamedThing alpha-latrotoxin receptor binding Binding to an alpha-latrotoxin receptor. got7fsn_ti latrophilin binding|lasso receptor binding dph 2016-04-13T10:46:42Z molecular_function owl:Class
GO:0045173 biolink:NamedThing O-sialoglycoprotein catabolic process The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities. got7fsn_ti O-sialoglycoprotein catabolism|O-sialoglycoprotein breakdown|O-sialoglycoprotein degradation biological_process owl:Class
GO:0052766 biolink:NamedThing mannoside alpha-1,4-mannosidase activity Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. got7fsn_ti mannoside exo-alpha-1,4-mannosidase activity|alpha-1,4-exomannosidase activity|alpha-1,4-mannosidase activity|mannoside alpha-1,4-exomannosidase activity ai 2011-09-30T12:55:24Z molecular_function owl:Class
GO:0004910 biolink:NamedThing interleukin-1, type II, blocking receptor activity Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors. got7fsn_ti interleukin-1 blocking receptor activity|IL-1 type II, blocking binding|interleukin-1, type II, blocking binding|IL-1 type II, blocking receptor|interleukin-1 type II receptor activity GO:0019968 molecular_function owl:Class
GO:0102869 biolink:NamedThing 6-hydroxyflavone-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + 6-hydroxyflavone <=> 6-O-beta-D-glucosyl-6-hydroxyflavone + UDP + H+. got7fsn_ti MetaCyc:RXN-8354 molecular_function owl:Class
GO:0103064 biolink:NamedThing inositol phosphorylceramide mannosyltransferase activity Catalysis of the reaction: a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1,6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H+. got7fsn_ti MetaCyc:RXN3O-663|EC:2.4.1.370|RHEA:64596|https://github.com/geneontology/go-ontology/issues/21803 molecular_function owl:Class
GO:0061591 biolink:NamedThing calcium activated galactosylceramide scrambling The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus. got7fsn_ti dph 2014-02-05T15:25:52Z biological_process owl:Class
GO:0007014 biolink:NamedThing actin ubiquitination The modification of actin by addition of ubiquitin groups. got7fsn_ti indirect flight muscle actin ubiquitination biological_process owl:Class
GO:0047699 biolink:NamedThing beta-diketone hydrolase activity Catalysis of the reaction: H(2)O + nonane-4,6-dione = butanoate + H(+) + pentan-2-one. got7fsn_ti b-diketone hydrolase activity|oxidized PVA hydrolase activity|nonane-4,6-dione acylhydrolase activity EC:3.7.1.7|KEGG_REACTION:R03781|MetaCyc:BETA-DIKETONE-HYDROLASE-RXN|RHEA:11908 molecular_function owl:Class
GO:1990224 biolink:NamedThing NMN phosphatase activity Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate. got7fsn_ti nicotinamide mononucleotide phosphatase activity|beta-nicotinamide D-ribonucleotide phosphatase activity rb 2013-10-21T18:03:41Z RHEA:30815 molecular_function owl:Class
GO:0006555 biolink:NamedThing methionine metabolic process The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. got7fsn_ti methionine and threonine metabolic process|methionine and threonine metabolism|methionine metabolism UM-BBD_pathwayID:met biological_process owl:Class
GO:0043876 biolink:NamedThing D-threonine aldolase activity Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde. got7fsn_ti low-specificity D-threonine aldolase|D-allo-TA|D-allo-threonine aldolase activity|D-TA|DtaAS MetaCyc:4.1.2.42-RXN|EC:4.1.2.42|RHEA:15257 molecular_function owl:Class
GO:0043530 biolink:NamedThing adenosine 5'-monophosphoramidase activity Catalysis of the reaction: adenosine 5'-monophosphoramidate + H2O = AMP + NH4+. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester. got7fsn_ti adenosine 5'-monophosphoramidate hydrolase activity|adenosine 5' monophosphoramidase activity molecular_function owl:Class
GO:0061703 biolink:NamedThing pyroptosome complex A protein complex that consists of an assemble of ASC dimers that is capable of inducing pyroptosis. got7fsn_ti ASC pyroptosome dph 2015-05-08T14:43:37Z cellular_component owl:Class
GO:0022009 biolink:NamedThing central nervous system vasculogenesis The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier. got7fsn_ti https://github.com/geneontology/go-ontology/issues/21480 biological_process owl:Class
GO:0071181 biolink:NamedThing MAML3-RBP-Jkappa-ICN3 complex A protein complex that consists of the intracellular domain of Notch3 (ICN3), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling. got7fsn_ti MAML3-RBP-Jkappa-Notch3 complex mah 2009-11-23T02:52:05Z cellular_component owl:Class
GO:1990085 biolink:NamedThing Hda-beta clamp complex A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda. got7fsn_ti Hda-DnaN complex|Hda-dpo3b complex bhm 2013-04-30T11:53:18Z cellular_component owl:Class
GO:0005872 biolink:NamedThing minus-end kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule. got7fsn_ti cellular_component owl:Class
GO:0019658 biolink:NamedThing glucose fermentation to lactate and acetate The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP. got7fsn_ti bifidum pathway|glucose catabolic process to lactate and acetate MetaCyc:P124-PWY biological_process owl:Class
GO:0050468 biolink:NamedThing reticuline oxidase activity Catalysis of the reaction: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) + H(+). got7fsn_ti berberine-bridge-forming enzyme activity|(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)|BBE|tetrahydroprotoberberine synthase activity|berberine bridge enzyme activity EC:1.21.3.3|MetaCyc:RETICULINE-OXIDASE-RXN|KEGG_REACTION:R03831|RHEA:19885 molecular_function owl:Class
GO:0030907 biolink:NamedThing MBF transcription complex A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p. got7fsn_ti MBF|Mlu1-box binding factor|DSC1 transcription factor complex cellular_component owl:Class
GO:0061675 biolink:NamedThing RBL family protein binding Binding to a member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose. got7fsn_ti rhamnose-binding lectin family protein binding dph 2015-01-10T18:22:42Z molecular_function owl:Class
GO:0006590 biolink:NamedThing thyroid hormone generation The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones. got7fsn_ti Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. biological_process owl:Class
GO:0070488 biolink:NamedThing neutrophil aggregation The adhesion of one neutrophil to one or more other neutrophils via adhesion molecules. got7fsn_ti neutrophil leukocyte aggregation|neutrophil leucocyte aggregation|neutrocyte aggregation|neutrophilic leucocyte aggregation|neutrophilic leukocyte aggregation biological_process owl:Class
GO:0090500 biolink:NamedThing endocardial cushion to mesenchymal transition A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. got7fsn_ti tb 2012-10-22T11:51:44Z biological_process owl:Class
GO:0090588 biolink:NamedThing protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in). got7fsn_ti tb 2014-06-04T16:22:31Z molecular_function owl:Class
GO:0031752 biolink:NamedThing D5 dopamine receptor binding Binding to a D5 dopamine receptor. got7fsn_ti D1B dopamine receptor binding|D5 dopamine receptor ligand molecular_function owl:Class
GO:0097500 biolink:NamedThing receptor localization to non-motile cilium A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium. got7fsn_ti receptor localization to nonmotile primary cilium pr 2013-08-13T12:17:34Z biological_process owl:Class
GO:0034851 biolink:NamedThing 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA. got7fsn_ti UM-BBD_reactionID:r1274 molecular_function owl:Class
GO:0022886 biolink:NamedThing channel-forming ionophore activity Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive. got7fsn_ti ionophore activity molecular_function owl:Class
GO:0046736 biolink:NamedThing induction of humoral immune response in host by virus The intentional, virally-encoded stimulation of a host humoral defense response to viral infection. got7fsn_ti active viral induction of humoral immune response in host|active induction of humoral immune response in host by virus biological_process owl:Class
GO:0060082 biolink:NamedThing eye blink reflex The reflex process in which a mechanical stimulus applied to the eye elicits a response of the eyelid closing. got7fsn_ti nictitating membrane reflex biological_process owl:Class
GO:0047056 biolink:NamedThing (S)-canadine synthase activity Catalysis of the reaction: (S)-tetrahydrocolumbamine + [reduced NADPH--hemoprotein reductase] + O2 -> (S)-canadine + [oxidized NADPH--hemoprotein reductase] + 2 H2O. got7fsn_ti (S)-tetrahydrocolumbamine oxidase (methylenedioxy-bridge-forming) activity|(S)-tetrahydroberberine synthase activity https://github.com/geneontology/go-ontology/issues/21133 RHEA:21456|EC:1.14.19.68|MetaCyc:1.1.3.36-RXN|KEGG_REACTION:R04400 molecular_function owl:Class
GO:0033951 biolink:NamedThing oligosaccharide reducing-end xylanase activity Catalysis of the hydrolysis of 1,4-beta-D-xylose residues from the reducing end of oligosaccharides. got7fsn_ti Rex|reducing end xylose-releasing exo-oligoxylanase activity|beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranosyl-(1->4)-beta-D-xylopyranose reducing-end xylanase activity MetaCyc:3.2.1.156-RXN|EC:3.2.1.156 molecular_function owl:Class
GO:0043000 biolink:NamedThing Golgi to plasma membrane CFTR protein transport The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane. got7fsn_ti Golgi to plasma membrane cystic fibrosis transmembrane conductance regulator protein transport biological_process owl:Class
GO:0043001 biolink:NamedThing Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane. got7fsn_ti biological_process owl:Class
GO:0050251 biolink:NamedThing retinol isomerase activity Catalysis of the reaction: all-trans-retinol = 11-cis-retinol. got7fsn_ti all-trans-retinol isomerase activity|all-trans-retinol 11-cis-trans-isomerase activity Reactome:R-HSA-2465926|MetaCyc:RETINOL-ISOMERASE-RXN|RHEA:19141|KEGG_REACTION:R02369 molecular_function owl:Class
GO:1900800 biolink:NamedThing cspyrone B1 metabolic process The chemical reactions and pathways involving cspyrone B1. got7fsn_ti cspyrone B1 metabolism di 2012-06-04T09:50:37Z biological_process owl:Class
GO:0097162 biolink:NamedThing MADS box domain binding Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs. got7fsn_ti pr 2011-09-27T10:10:59Z molecular_function owl:Class
GO:0102789 biolink:NamedThing UDP-D-glucose:cyanidin 5-O-beta-D-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cyanidin = H+ + cyanidin 5-O-beta-D-glucoside + UDP. got7fsn_ti MetaCyc:RXN-8005 molecular_function owl:Class
GO:0062185 biolink:NamedThing secalciferol 1-monooxygenase activity Catalysis of the reaction:2 H(+) + O2 + 2 reduced [adrenodoxin] + secalciferol = calcitetrol + H2O + 2 oxidized [adrenodoxin]. got7fsn_ti dph 2019-11-26T18:46:18Z RHEA:49064 molecular_function owl:Class
GO:0106356 biolink:NamedThing 4-hydroxybenzoate 3-monooxygenase [NADPH] activity Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADPH + O2 = 3,4-dihydroxybenzoate + H2O + NADP+. got7fsn_ti hjd 2021-02-02T05:51:57Z RHEA:19477 molecular_function owl:Class
GO:0001965 biolink:NamedThing G-protein alpha-subunit binding Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. got7fsn_ti G-alpha protein subunit binding molecular_function owl:Class
GO:0018669 biolink:NamedThing 3-hydroxybenzoate 6-monooxygenase activity Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+). got7fsn_ti 3-hydroxybenzoic acid-6-hydroxylase activity|3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)|m-hydroxybenzoate 6-hydroxylase activity|3-hydroxybenzoate 6-hydroxylase activity RHEA:22692|KEGG_REACTION:R02589|EC:1.14.13.24|UM-BBD_reactionID:r0402|MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN molecular_function owl:Class
GO:0102289 biolink:NamedThing beta-amyrin 11-oxidase activity Catalysis of the reaction: beta-amyrin + 2 O2 + 2 NADPH + 2 H+ <=> 11-oxo-beta-amyrin + 3 H2O + 2 NADP. got7fsn_ti EC:1.14.14.152|MetaCyc:RXN-12680|RHEA:31711 molecular_function owl:Class
GO:0047030 biolink:NamedThing 4-hydroxycyclohexanecarboxylate dehydrogenase activity Catalysis of the reaction: trans-4-hydroxycyclohexanecarboxylate + NAD(+) = 4-oxocyclohexanecarboxylate + H(+) + NADH. got7fsn_ti trans-4-hydroxycyclohexanecarboxylate dehydrogenase activity|trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase activity KEGG_REACTION:R04307|EC:1.1.1.226|MetaCyc:1.1.1.226-RXN|RHEA:17429 molecular_function owl:Class
GO:0060307 biolink:NamedThing regulation of ventricular cardiac muscle cell membrane repolarization Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte. got7fsn_ti electrocardiogram T wave|regulation of ventricular cardiac muscle cell repolarization|regulation of ventricular cardiac muscle repolarization|ventricular repolarization|regulation of ventricular cardiomyocyte membrane repolarization biological_process owl:Class
GO:0099623 biolink:NamedThing regulation of cardiac muscle cell membrane repolarization Any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte. got7fsn_ti regulation of cardiac muscle cell repolarization|heart repolarization|regulation of cardiomyocyte membrane repolarization biological_process owl:Class
GO:0046025 biolink:NamedThing precorrin-6Y C5,15-methyltransferase (decarboxylating) activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + precorrin-6Y = 2 S-adenosyl-L-homocysteine + precorrin-8X + CO2. got7fsn_ti precorrin-6 methyltransferase activity|S-adenosyl-L-methionine:1-precorrin-6Y C5,15-methyltransferase (C-12-decarboxylating)|precorrin-6Y methylase activity EC:2.1.1.132|RHEA:17477|MetaCyc:2.1.1.132-RXN molecular_function owl:Class
GO:0052749 biolink:NamedThing glucose-6-phosphate dehydrogenase (coenzyme F420) activity Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420. got7fsn_ti coenzyme F420-dependent glucose-6-phosphate dehydrogenase activity|D-glucose-6-phosphate:F420 1-oxidoreductase activity|F420-dependent glucose-6-phosphate dehydrogenase activity ai 2011-09-21T01:21:54Z MetaCyc:RXN-11283|EC:1.1.98.2|KEGG_REACTION:R09550|RHEA:27294 molecular_function owl:Class
GO:0097424 biolink:NamedThing nucleolus-associated heterochromatin Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus. got7fsn_ti pr 2012-11-07T13:43:17Z NIF_Subcellular:sao1210952635 cellular_component owl:Class
GO:0061743 biolink:NamedThing motor learning Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience. got7fsn_ti dph 2015-11-09T12:40:29Z biological_process owl:Class
GO:0140610 biolink:NamedThing RNA sequestering activity The selective interaction of a protein with a specific RNA molecule to prevent it from interacting with other partners or inhibiting its localization to other areas of the cell. got7fsn_ti https://github.com/geneontology/go-ontology/issues/20945 pg 2021-02-24T13:53:46Z molecular_function owl:Class
GO:0042819 biolink:NamedThing vitamin B6 biosynthetic process The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. got7fsn_ti vitamin B6 biosynthesis|vitamin B6 anabolism|pyridoxine-5'-phosphate biosynthesis|vitamin B6 formation|vitamin B6 synthesis biological_process owl:Class
GO:0018612 biolink:NamedThing dibenzothiophene dioxygenase activity Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene. got7fsn_ti EC:1.14.12.-|UM-BBD_reactionID:r0160 molecular_function owl:Class
GO:0102217 biolink:NamedThing 6-phosphoglucan, water dikinase activity Catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin. got7fsn_ti MetaCyc:RXN-12202|EC:2.7.9.5|RHEA:10256 molecular_function owl:Class
GO:0007505 biolink:NamedThing adult fat body development The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body. got7fsn_ti biological_process owl:Class
GO:0033983 biolink:NamedThing diaminobutyrate decarboxylase activity Catalysis of the reaction: L-2,4-diaminobutyrate + H(+) = 1,3-diaminopropane + CO(2). got7fsn_ti L-2,4-diaminobutanoate carboxy-lyase (propane-1,3-diamine-forming) activity|L-2,4-diaminobutyrate decarboxylase activity|DABA DC|L-2,4-diaminobutanoate carboxy-lyase activity MetaCyc:4.1.1.86-RXN|RHEA:15689|KEGG_REACTION:R07650|EC:4.1.1.86 molecular_function owl:Class
GO:0005112 biolink:NamedThing Notch binding Binding to a Notch (N) protein, a surface receptor. got7fsn_ti N ligand|Notch ligand|N binding|Notch receptor binding molecular_function owl:Class
GO:0042004 biolink:NamedThing feminization of hermaphrodite soma Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans. got7fsn_ti biological_process owl:Class
GO:0072645 biolink:NamedThing interferon-delta production The appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti IFND production|IFN-delta production|interferon-delta secretion Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms. GO:0072646 biological_process owl:Class
GO:0034191 biolink:NamedThing apolipoprotein A-I receptor binding Binding to an apolipoprotein A-I receptor. got7fsn_ti Note that this term is to be used only to annotate gene products that bind to lipid-free APOA1. For receptors that bind lipid-associated apolipoproteins (plasma lipoprotein particles), consider annotating to 'lipoprotein receptor activity ; GO:0030228' or its child terms. molecular_function owl:Class
GO:0061344 biolink:NamedThing regulation of cell adhesion involved in heart morphogenesis Any process that modulates the extent of cell adhesion contributing to the shaping of the heart. got7fsn_ti dph 2010-09-29T11:35:27Z biological_process owl:Class
GO:0009924 biolink:NamedThing octadecanal decarbonylase activity Catalysis of the reaction: octadecanal = heptadecane + CO. got7fsn_ti octadecanal alkane-lyase activity RHEA:30415|EC:4.1.99.5|MetaCyc:OCTADECANAL-DECARBONYLASE-RXN molecular_function owl:Class
GO:0097507 biolink:NamedThing hypoxanthine DNA N-glycosylase activity DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine). got7fsn_ti hypoxanthine-DNA glycosylase activity pr 2013-09-26T16:02:08Z molecular_function owl:Class
GO:0047669 biolink:NamedThing amylosucrase activity Catalysis of the reaction: sucrose + 1,4-alpha-D-glucosyl(n) = D-fructose + 1,4-alpha-D-glucosyl(n+1). got7fsn_ti sucrose-1,4-alpha-glucan glucosyltransferase activity|sucrose-glucan glucosyltransferase activity|sucrose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity EC:2.4.1.4|RHEA:24572|MetaCyc:AMYLOSUCRASE-RXN molecular_function owl:Class
GO:0080102 biolink:NamedThing 3-methylthiopropyl glucosinolate S-oxygenase activity Catalysis of the reaction: 3-methylthiopropyl-glucosinolate = 3-methylsulfinylpropyl-glucosinolate. got7fsn_ti dhl 2009-04-23T04:26:41Z MetaCyc:RXN-2221 molecular_function owl:Class
GO:1901222 biolink:NamedThing regulation of NIK/NF-kappaB signaling Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling. got7fsn_ti regulation of NF-kappaB import into nucleus|NF-KB import into nucleus|NF-kappaB import into nucleus|regulation of NIK/NF-kappaB cascade|regulation of non-canonical NF-KB signaling|regulation of noncanonical NF-kappaB signaling|regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|regulation of p52-dependent NF-kappaB signaling hjd 2012-08-06T20:27:17Z GO:0042348|GO:0042345 biological_process owl:Class
GO:0071250 biolink:NamedThing cellular response to nitrite Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrite stimulus. got7fsn_ti mah 2009-12-03T03:03:49Z biological_process owl:Class
GO:1990418 biolink:NamedThing response to insulin-like growth factor stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus. got7fsn_ti sl 2014-07-14T22:47:59Z biological_process owl:Class
GO:0102418 biolink:NamedThing luteolin-7-O-glucoside 1,6-glucosyltransferase activity Catalysis of the reaction: luteolin 7-O-beta-D-glucoside + UDP-alpha-D-glucose = luteolin-7-O-gentiobioside + UDP + H+. got7fsn_ti MetaCyc:RXN-13801 molecular_function owl:Class
GO:0047898 biolink:NamedThing formate dehydrogenase (cytochrome) activity Catalysis of the reaction: formate + ferricytochrome b1 = CO2 + ferrocytochrome b1. got7fsn_ti formate:cytochrome b1 oxidoreductase activity|formate:ferricytochrome-b1 oxidoreductase activity EC:1.2.2.1|RHEA:21520|MetaCyc:FORMATE-DEHYDROGENASE-CYTOCHROME-RXN molecular_function owl:Class
GO:0018585 biolink:NamedThing fluorene oxygenase activity Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol. got7fsn_ti UM-BBD_reactionID:r0407 molecular_function owl:Class
GO:0102152 biolink:NamedThing Delta12-linoleate epoxygenase activity Catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 <=> 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O. got7fsn_ti MetaCyc:RXN-11671 molecular_function owl:Class
GO:0045687 biolink:NamedThing positive regulation of glial cell differentiation Any process that activates or increases the frequency, rate or extent of glia cell differentiation. got7fsn_ti activation of glial cell differentiation|stimulation of glial cell differentiation|positive regulation of glia cell differentiation|up regulation of glial cell differentiation|positive regulation of neuroglia differentiation|up-regulation of glial cell differentiation|upregulation of glial cell differentiation biological_process owl:Class
GO:0047489 biolink:NamedThing pectate disaccharide-lyase activity Catalysis of the reaction: a pectate = a pectate + 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate. This reaction is the eliminative cleavage of 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate from the reducing end of pectate, i.e. de-esterified pectin. got7fsn_ti exopectic acid transeliminase activity|(1->4)-alpha-D-galacturonan reducing-end-disaccharide-lyase activity|exo-PATE|Exo-PATE activity|exopectate lyase activity|PATE activity|Exo-PGL activity|exopolygalacturonic acid-trans-eliminase activity|exo-PGL|pectate exo-lyase activity|exopolygalacturonate lyase activity MetaCyc:4.2.2.9-RXN|RHEA:57104|EC:4.2.2.9 molecular_function owl:Class
GO:0019423 biolink:NamedThing sulfur oxidation, ferric ion-dependent A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+). got7fsn_ti sulphur oxidation, ferric ion-dependent MetaCyc:FESULFOX-PWY biological_process owl:Class
GO:0047572 biolink:NamedThing 3-phosphoglycerate phosphatase activity Catalysis of the reaction: 3-phospho-D-glycerate + H(2)O = D-glycerate + phosphate. got7fsn_ti D-3-phosphoglycerate phosphatase activity|3-PGA phosphatase activity|D-glycerate-3-phosphate phosphohydrolase activity EC:3.1.3.38|RHEA:12412|KEGG_REACTION:R01511|MetaCyc:3-PHOSPHOGLYCERATE-PHOSPHATASE-RXN molecular_function owl:Class
GO:0140563 biolink:NamedThing UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity Catalyzes the reaction: UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. got7fsn_ti https://github.com/geneontology/go-ontology/issues/16869 pg 2020-11-25T16:07:58Z RHEA:56064|EC:2.4.2.42 molecular_function owl:Class
GO:0098576 biolink:NamedThing lumenal side of membrane Any side (leaflet) of a membrane that faces the lumen of an organelle. got7fsn_ti cellular_component owl:Class
GO:0034816 biolink:NamedThing anthracene 9,10-dioxygenase activity Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol. got7fsn_ti UM-BBD_reactionID:r1141 molecular_function owl:Class
GO:0047585 biolink:NamedThing 4-pyridoxolactonase activity Catalysis of the reaction: 4-pyridoxolactone + H(2)O = 4-pyridoxate + H(+). got7fsn_ti 4-pyridoxolactone lactonohydrolase activity MetaCyc:4-PYRIDOXOLACTONASE-RXN|EC:3.1.1.27|RHEA:14301|KEGG_REACTION:R02992 molecular_function owl:Class
GO:0042283 biolink:NamedThing dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol. got7fsn_ti dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase activity RHEA:31307|EC:2.4.1.265|MetaCyc:RXN-5471 molecular_function owl:Class
GO:0016631 biolink:NamedThing enoyl-[acyl-carrier-protein] reductase activity Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+. got7fsn_ti enoyl-ACP reductase activity|acyl-ACP dehydrogenase activity|enoyl-[acyl-carrier protein] reductase activity|enoyl-acyl carrier protein reductase MetaCyc:RXN1G-2527|MetaCyc:RXN1G-2544|MetaCyc:RXN1G-3667|MetaCyc:RXN1G-3232|Wikipedia:Enoyl-acyl_carrier_protein_reductase|MetaCyc:RXN1G-4140|MetaCyc:RXN1G-3613|MetaCyc:RXN1G-3993|MetaCyc:1.3.1.39-RXN|MetaCyc:RXN1G-45|MetaCyc:1.3.1.10-RXN|MetaCyc:RXN1G-3256|EC:1.3.1.9|MetaCyc:RXN1G-3641 molecular_function owl:Class
GO:0018765 biolink:NamedThing 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate. got7fsn_ti RHEA:59220|MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN|UM-BBD_reactionID:r0263 molecular_function owl:Class
GO:0045337 biolink:NamedThing farnesyl diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of farnesyl diphosphate. got7fsn_ti farnesyl diphosphate biosynthesis|farnesyl diphosphate synthesis|farnesyl diphosphate anabolism|farnesyl diphosphate formation MetaCyc:PWY-5123 biological_process owl:Class
GO:0090430 biolink:NamedThing caffeoyl-CoA: alcohol caffeoyl transferase activity Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA. got7fsn_ti tb 2012-07-25T10:48:15Z molecular_function owl:Class
GO:0140460 biolink:NamedThing response to Gram-negative bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-negative bacterium. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19278 pg 2020-04-30T07:34:38Z biological_process owl:Class
GO:0047659 biolink:NamedThing alpha-santonin 1,2-reductase activity Catalysis of the reaction: 1,2-dihydrosantonin + NAD(P)+ = alpha-santonin + NAD(P)H + H+. got7fsn_ti a-santonin 1,2-reductase activity|1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity EC:1.3.1.47|MetaCyc:ALPHA-SANTONIN-12-REDUCTASE-RXN molecular_function owl:Class
GO:0034694 biolink:NamedThing response to prostaglandin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin stimulus. got7fsn_ti response to prostaglandin stimulus biological_process owl:Class
GO:1903189 biolink:NamedThing glyoxal metabolic process The chemical reactions and pathways involving glyoxal. got7fsn_ti glyoxal metabolism bf 2014-07-15T10:11:45Z biological_process owl:Class
GO:0102912 biolink:NamedThing (-)-lactol dehydrogenase activity Catalysis of the reaction: (-)-lactol + NAD <=> H+ + (-)-matairesinol + NADH. got7fsn_ti MetaCyc:RXN-8681 molecular_function owl:Class
GO:0102168 biolink:NamedThing 5-methyl-phenazine-1-carboxylate N-methyltransferase activity Catalysis of the reaction: phenazine-1-carboxylate + S-adenosyl-L-methionine <=> 5-methylphenazine-1-carboxylate + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-11897|RHEA:49112 molecular_function owl:Class
GO:0018111 biolink:NamedThing methionine racemase activity Catalysis of the reaction: L-methionine = D-methionine. got7fsn_ti RHEA:12492|KEGG_REACTION:R00655|MetaCyc:METHIONINE-RACEMASE-RXN|EC:5.1.1.2 molecular_function owl:Class
GO:0050020 biolink:NamedThing L-arabinonate dehydratase activity Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O. got7fsn_ti L-arabinonate hydro-lyase activity|L-arabonate dehydrase activity|L-arabonate dehydratase activity|L-arabinonate hydro-lyase (2-dehydro-3-deoxy-L-arabinonate-forming) EC:4.2.1.25|KEGG_REACTION:R02522|MetaCyc:L-ARABINONATE-DEHYDRATASE-RXN|RHEA:20968 molecular_function owl:Class
GO:0051506 biolink:NamedThing ergosterol UDP-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + ergosterol = UDP + O-glucosyl-ergosterol. got7fsn_ti MetaCyc:RXN-16975)|RHEA:61836 molecular_function owl:Class
GO:0052694 biolink:NamedThing jasmonoyl-isoleucine-12-hydroxylase activity Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O. got7fsn_ti MetaCyc:RXN-12421|RHEA:54808 molecular_function owl:Class
GO:0018518 biolink:NamedThing 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH. got7fsn_ti 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity|5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase MetaCyc:RXN-643|UM-BBD_reactionID:r0053|EC:1.3.1.65|KEGG_REACTION:R05312|RHEA:24556 molecular_function owl:Class
GO:0003244 biolink:NamedThing radial growth involved in right ventricle morphogenesis The morphogenic growth in which the right ventricle grows along a radial axis. got7fsn_ti dph 2009-10-13T11:38:23Z biological_process owl:Class
GO:0033054 biolink:NamedThing D-glutamate metabolic process The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid. got7fsn_ti D-glutamate metabolism biological_process owl:Class
GO:0002548 biolink:NamedThing monocyte chemotaxis The movement of a monocyte in response to an external stimulus. got7fsn_ti biological_process owl:Class
GO:0010878 biolink:NamedThing cholesterol storage The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. got7fsn_ti cholesterol sequestration|sequestration of cholesterol biological_process owl:Class
GO:0102793 biolink:NamedThing soyasapogenol B glucuronosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucuronate + soyasapogenol B <=> H+ + UDP + soyasapogenol B 3-O-beta-glucuronate. got7fsn_ti RHEA:31475|MetaCyc:RXN-8086|EC:2.4.1.262 molecular_function owl:Class
GO:0042586 biolink:NamedThing peptide deformylase activity Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. got7fsn_ti polypeptide deformylase activity|PDF activity|formyl-L-methionyl peptide amidohydrolase activity MetaCyc:3.5.1.88-RXN|EC:3.5.1.88|RHEA:24420 molecular_function owl:Class
GO:0060250 biolink:NamedThing germ-line stem-cell niche homeostasis A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion. got7fsn_ti germ-line stem-cell niche maintenance|maintenance of germ line stem-cell niche|maintenance of germ line stem cell niche|maintenance of germ-line stem-cell niche|maintenance of germ-line stem cell niche biological_process owl:Class
GO:0080013 biolink:NamedThing (E,E)-geranyllinalool synthase activity Catalysis of the reaction: all-trans-geranyl-geranyl diphosphate + H2O = (E,E)-geranyllinalool + diphosphate. got7fsn_ti MetaCyc:RXN-10441|RHEA:38155 molecular_function owl:Class
GO:0004837 biolink:NamedThing tyrosine decarboxylase activity Catalysis of the reaction: L-tyrosine = tyramine + CO2. got7fsn_ti L-tyrosine decarboxylase activity|L-(-)-tyrosine apodecarboxylase activity|L-tyrosine carboxy-lyase activity|L-tyrosine carboxy-lyase (tyramine-forming) RHEA:14345|MetaCyc:TYROSINE-DECARBOXYLASE-RXN|EC:4.1.1.25 molecular_function owl:Class
GO:0102575 biolink:NamedThing 3-oxo-dodecanoyl-ACP hydrolase activity Catalysis of the reaction: H2O + a 3-oxo-dodecanoyl-[acp] = 3-oxododecanoate + H+ + a holo-[acyl-carrier protein]. got7fsn_ti MetaCyc:RXN-15281 molecular_function owl:Class
GO:0030795 biolink:NamedThing methyl jasmonate methylesterase activity Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate. got7fsn_ti S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity|S-adenosyl-L-methionine:jasmonate O-methyltransferase activity|jasmonic acid carboxyl methyltransferase activity GO:0102078|GO:0045546 EC:2.1.1.141|MetaCyc:RXN-10768|RHEA:13349 molecular_function owl:Class
GO:0003680 biolink:NamedThing minor groove of adenine-thymine-rich DNA binding Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins. got7fsn_ti AT binding|AT DNA binding|AT-rich DNA binding https://github.com/geneontology/go-ontology/issues/19695 molecular_function owl:Class
GO:0047678 biolink:NamedThing arginine 2-monooxygenase activity Catalysis of the reaction: L-arginine + O(2) = 4-guanidinobutanamide + CO(2) + H(2)O. got7fsn_ti arginine oxygenase (decarboxylating) activity|L-arginine:oxygen 2-oxidoreductase (decarboxylating)|arginine decarboxy-oxidase activity|arginine monooxygenase activity KEGG_REACTION:R00559|MetaCyc:ARGININE-2-MONOOXYGENASE-RXN|EC:1.13.12.1|RHEA:10548 molecular_function owl:Class
GO:0034847 biolink:NamedThing naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-. got7fsn_ti UM-BBD_reactionID:r1260 molecular_function owl:Class
GO:0034677 biolink:NamedThing integrin alpha7-beta1 complex An integrin complex that comprises one alpha7 subunit and one beta1 subunit. got7fsn_ti ITGA7-ITGB1 complex|alpha7-beta1 integrin complex cellular_component owl:Class
GO:0090638 biolink:NamedThing phosphatidylcholine biosynthesis from phosphatidylethanolamine The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations. got7fsn_ti tb 2015-04-23T15:56:12Z biological_process owl:Class
GO:0019727 biolink:NamedThing mevaldate reductase (NAD+) activity Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH. got7fsn_ti EC:1.1.1.32|KEGG_REACTION:R02246|RHEA:13221|MetaCyc:MEVALDATE-REDUCTASE-RXN molecular_function owl:Class
GO:0097279 biolink:NamedThing histamine secretion mediated by IgE immunoglobulin Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen. got7fsn_ti histamine secretion mediated by IgE antibody|Ig-mediated histamine release pr 2012-03-22T06:42:13Z biological_process owl:Class
GO:0060813 biolink:NamedThing anterior mRNA localization involved in anterior/posterior axis specification Any process in which a mRNA is transported to, and maintained in the anterior portion of the oocyte and/or syncytial embryo contributing to the specification of the anterior/posterior axis. got7fsn_ti anterior mRNA localisation involved in anterior/posterior axis specification dph 2009-08-07T09:51:47Z biological_process owl:Class
GO:0061486 biolink:NamedThing high-affinity fructose transmembrane transporter activity Enables the transfer of fructose from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. got7fsn_ti high affinity fructose transmembrane transporter activity dph 2012-12-04T10:34:55Z molecular_function owl:Class
GO:0120053 biolink:NamedThing ribitol beta-1,4-xylosyltransferase activity Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R. got7fsn_ti krc 2017-06-13T19:35:01Z molecular_function owl:Class
GO:0072585 biolink:NamedThing xanthosine nucleotidase activity Catalysis of the reaction: xanthosine + H2O = D-ribose + xanthine. got7fsn_ti xanthosine ribohydrolase activity mah 2011-02-08T04:38:31Z MetaCyc:RXN0-363|RHEA:27994 molecular_function owl:Class
GO:0046414 biolink:NamedThing organomercury biosynthetic process The chemical reactions and pathways resulting in the formation of organomercury compounds, any organic compound containing a mercury atom. got7fsn_ti organomercury anabolism|organomercury biosynthesis|organomercury formation|organomercury synthesis biological_process owl:Class
GO:0050280 biolink:NamedThing sequoyitol dehydrogenase activity Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH. got7fsn_ti 5-O-methyl-myo-inositol:NAD+ oxidoreductase activity KEGG_REACTION:R03497|MetaCyc:SEQUOYITOL-DEHYDROGENASE-RXN|RHEA:11300|EC:1.1.1.143 molecular_function owl:Class
GO:0086005 biolink:NamedThing ventricular cardiac muscle cell action potential An action potential that occurs in a ventricular cardiac muscle cell. got7fsn_ti tb 2011-11-10T07:59:36Z biological_process owl:Class
GO:0005119 biolink:NamedThing smoothened binding Binding to a smoothened (smo) protein, which interacts with patched to transmit hedgehog signals. got7fsn_ti smo ligand|smo binding|smoothened ligand molecular_function owl:Class
GO:0034535 biolink:NamedThing 1,2-dihydroxy-8-methylnaphthalene dioxygenase activity Catalysis of the reaction: 1,2-dihydroxy-8-methylnaphthalene + O2 = 2-hydroxy-8-methylchromene-2-carboxylate + H+. got7fsn_ti UM-BBD_reactionID:r0781 molecular_function owl:Class
GO:0048941 biolink:NamedThing posterior lateral line nerve glial cell development The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. got7fsn_ti biological_process owl:Class
GO:0019101 biolink:NamedThing female somatic sex determination The determination of sex and sexual phenotypes in a female organism's soma. got7fsn_ti biological_process owl:Class
GO:0080131 biolink:NamedThing hydroxyjasmonate sulfotransferase activity Catalysis of the reaction: a hydroxyjasmonate + 3'-phosphoadenosine-5'-phosphosulfate = a hydroxyjasmonate sulfate + adenosine-3',5'-diphosphate. got7fsn_ti hydroxyjasmonic acid sulfotransferase activity|OHJA sulfotransferase activity|12-hydroxyjasmonic acid sulfotransferase activity|12-hydroxyjasmonate sulfotransferase activity|12-OHJA sulfotransferase activity|11-hydroxyjasmonate sulfotransferase activity|11-hydroxyjasmonic acid sulfotransferase activity|11-OHJA sulfotransferase activity dhl 2009-04-29T03:47:12Z molecular_function owl:Class
GO:0052809 biolink:NamedThing acharan sulfate lyase activity Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid. got7fsn_ti ai 2011-09-26T02:58:28Z molecular_function owl:Class
GO:0062188 biolink:NamedThing anandamide 11,12 epoxidase activity Catalysis of the reaction: N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + N-(11,12-epoxy-5Z,8Z,14Z-eicosatrienoyl)-ethanolamine + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti dph 2019-11-26T18:53:52Z RHEA:53144 molecular_function owl:Class
GO:0102712 biolink:NamedThing gibberellin A13,oxoglutarate:oxygen oxidoreductase activity Catalysis of the reaction: gibberellin A13 + 2-oxoglutarate + O2 <=> gibberellin A43 + succinate + carbon dioxide. got7fsn_ti MetaCyc:RXN-6542 molecular_function owl:Class
GO:0033728 biolink:NamedThing divinyl chlorophyllide a 8-vinyl-reductase activity Catalysis of the reaction: chlorophyllide a + NADP+ = divinyl chlorophyllide a + NADPH + H+. got7fsn_ti [4-vinyl]chlorophyllide a reductase activity|4VCR|chlorophyllide-a:NADP+ oxidoreductase activity RHEA:14449|MetaCyc:RXN-5286|EC:1.3.1.75 molecular_function owl:Class
GO:0120106 biolink:NamedThing mitotic actomyosin contractile ring, distal actin filament layer The region of the mitotic actomyosin ring containing actin filaments and cross linkers, myosin motors, and connections to the plasma membrane through the intermediate layer. It is further from the plasma membrane than the intermediate layer which it is adjacent to. got7fsn_ti actomyosin contractile ring, distal actin filament layer krc 2017-10-11T22:56:44Z cellular_component owl:Class
GO:0047339 biolink:NamedThing nucleoside-triphosphate-hexose-1-phosphate nucleotidyltransferase activity Catalysis of the reaction: hexose 1-phosphate + nucleoside triphosphate = NDP-hexose + diphosphate. got7fsn_ti nucleoside diphosphohexose pyrophosphorylase activity|NDP-hexose diphosphorylase activity|NTP:alpha-D-aldose-1-phosphate nucleotidyltransferase activity|hexose-1-phosphate guanylyltransferase activity|GTP:alpha-D-hexose-1-phosphate guanylyltransferase activity|hexose 1-phosphate nucleotidyltransferase activity|NDP hexose pyrophosphorylase activity|hexose 1-phosphate guanylyltransferase activity|NTP:hexose-1-phosphate nucleotidyltransferase activity|nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase activity|guanosine diphosphohexose pyrophosphorylase activity|GDP hexose pyrophosphorylase activity|hexose nucleotidylating enzyme activity|NDP-hexose pyrophosphorylase activity|GTP:hexose-1-phosphate guanylyltransferase activity GO:0047340 MetaCyc:2.7.7.28-RXN|EC:2.7.7.28 molecular_function owl:Class
GO:0044296 biolink:NamedThing dendritic tuft The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance. got7fsn_ti dendrite tuft jl 2010-02-04T04:03:29Z NIF_Subcellular:sao1340260079 cellular_component owl:Class
GO:0047528 biolink:NamedThing 2,3-dihydroxyindole 2,3-dioxygenase activity Catalysis of the reaction: 2,3-dihydroxyindole + O(2) = anthranilate + CO(2) + H(+). got7fsn_ti 2,3-dihydroxyindole:oxygen 2,3-oxidoreductase (decyclizing) activity RHEA:19445|KEGG_REACTION:R00983|MetaCyc:23-DIHYDROXYINDOLE-23-DIOXYGENASE-RXN|EC:1.13.11.23 molecular_function owl:Class
GO:0003989 biolink:NamedThing acetyl-CoA carboxylase activity Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. got7fsn_ti acetyl-CoA:carbon-dioxide ligase (ADP-forming)|acetyl coenzyme A carboxylase activity EC:6.4.1.2|RHEA:11308|Reactome:R-HSA-75851|Reactome:R-HSA-8876889|Reactome:R-HSA-200555|MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN molecular_function owl:Class
GO:0072099 biolink:NamedThing anterior/posterior pattern specification involved in ureteric bud development The developmental process that results in the creation of defined areas or spaces within the ureteric bud along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate. got7fsn_ti ureteric bud anterior/posterior pattern formation mah 2010-02-10T02:12:09Z biological_process owl:Class
GO:0000140 biolink:NamedThing acylglycerone-phosphate reductase activity Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+). got7fsn_ti palmitoyl dihydroxyacetone phosphate reductase activity|palmitoyl-dihydroxyacetone-phosphate reductase activity|palmitoyldihydroxyacetone-phosphate reductase activity|1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity|acyldihydroxyacetone phosphate reductase activity|1-acyldihydroxyacetone-phosphate reductase activity MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN|RHEA:17341|Reactome:R-HSA-75883|EC:1.1.1.101 molecular_function owl:Class
GO:0046500 biolink:NamedThing S-adenosylmethionine metabolic process The chemical reactions and pathways involving S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism. got7fsn_ti S-adenosyl methionine metabolism|SAM metabolic process|S-adenosyl methionine metabolic process|S-adenosylmethionine metabolism biological_process owl:Class
GO:0047366 biolink:NamedThing quercetin-3-sulfate 4'-sulfotransferase activity Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + quercetin 3-sulfate = adenosine 3',5'-diphosphate + H(+) + quercetin 3,4'-disulfate. got7fsn_ti quercetin-3-sulphate 4'-sulphotransferase activity|3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 4'-sulfotransferase activity|PAPS:flavonol 3-sulfate 4'-sulfotransferase activity|flavonol 4'-sulfotransferase activity EC:2.8.2.27|KEGG_REACTION:R02633|MetaCyc:2.8.2.27-RXN|RHEA:17205 molecular_function owl:Class
GO:0099549 biolink:NamedThing trans-synaptic signaling by carbon monoxide Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide. got7fsn_ti biological_process owl:Class
GO:0032531 biolink:NamedThing regulation of follicle cell microvillus organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. got7fsn_ti regulation of follicle cell microvillus organization and biogenesis|regulation of follicle cell microvillus organisation biological_process owl:Class
GO:0010188 biolink:NamedThing response to microbial phytotoxin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants. got7fsn_ti biological_process owl:Class
GO:0018811 biolink:NamedThing cyclohex-1-ene-1-carboxyl-CoA hydratase activity Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA. got7fsn_ti MetaCyc:R266-RXN|UM-BBD_reactionID:r0191 molecular_function owl:Class
GO:0008611 biolink:NamedThing ether lipid biosynthetic process The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. got7fsn_ti ether lipid anabolism|ether lipid biosynthesis|plasmalogen biosynthetic process|ether lipid synthesis|ether lipid formation biological_process owl:Class
GO:0018676 biolink:NamedThing (S)-limonene 7-monooxygenase activity Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+). got7fsn_ti (-)-limonene 7-monooxygenase activity UM-BBD_reactionID:r0728|RHEA:23432|MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN|KEGG_REACTION:R02470|EC:1.14.14.52 molecular_function owl:Class
GO:0062021 biolink:NamedThing mitotic cohesin dsDNA (leading strand) loading The protein localization to chromatin by which a cohesin ring complex is topologically linked to dsDNA (leading strand) as part of the mitotic cell cycle. got7fsn_ti dph 2018-04-06T13:04:41Z biological_process owl:Class
GO:0046959 biolink:NamedThing habituation A decrease in a behavioral response to a repeated stimulus. This is exemplified by the failure of a person to show a startle response to a loud noise that has been repeatedly presented. got7fsn_ti Wikipedia:Habituation biological_process owl:Class
GO:0010084 biolink:NamedThing specification of animal organ axis polarity The process in which the polarity of an animal organ axis is specified. got7fsn_ti biological_process owl:Class
GO:0097261 biolink:NamedThing eoxin C4 synthase activity Catalysis of the reaction: eoxin A4 + glutathione = eoxin C4. got7fsn_ti pr 2012-03-08T02:59:00Z Reactome:R-HSA-2161768 molecular_function owl:Class
GO:0034577 biolink:NamedThing N-isopropylacetaniline monooxygenase activity Catalysis of the reaction: N-isopropylacetanilide + 1/2 O2 = acetanilide + acetone. got7fsn_ti UM-BBD_reactionID:r0914|EC:1.14.15.- molecular_function owl:Class
GO:0071797 biolink:NamedThing LUBAC complex A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex. got7fsn_ti mah 2010-09-02T04:09:55Z cellular_component owl:Class
GO:1990140 biolink:NamedThing MPT synthase complex A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved. got7fsn_ti molybdopterin cofactor (Moco) biosynthesis sulfurtransferase complex pr 2013-07-11T08:32:29Z cellular_component owl:Class
GO:0097671 biolink:NamedThing SCF-YDR131C ubiquitin ligase complex An SCF ubiquitin ligase complex in which the F-box protein is YDR131C in S. cerevisiae. got7fsn_ti pr 2014-10-06T10:29:35Z cellular_component owl:Class
GO:0050274 biolink:NamedThing salicyl-alcohol beta-D-glucosyltransferase activity Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H(+) + salicin + UDP. got7fsn_ti salicyl-alcohol b-D-glucosyltransferase activity|UDP-glucose:salicyl-alcohol beta-D-glucosyltransferase activity|salicyl-alcohol glucosyltransferase activity|UDPglucose:salicyl alcohol phenyl-glucosyltransferase activity|UDPglucose:salicyl-alcohol beta-D-glucosyltransferase activity|uridine diphosphoglucose-salicyl alcohol 2-glucosyltransferase activity EC:2.4.1.172|RHEA:11512|MetaCyc:SALICYL-ALCOHOL-GLUCOSYLTRANSFERASE-RXN|KEGG_REACTION:R03558 molecular_function owl:Class
GO:0046966 biolink:NamedThing thyroid hormone receptor binding Binding to a thyroid hormone receptor. got7fsn_ti ligand-dependent thyroid hormone receptor interactor activity molecular_function owl:Class
GO:0070703 biolink:NamedThing outer mucus layer The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria. got7fsn_ti mah 2009-06-08T02:44:51Z cellular_component owl:Class
GO:0004475 biolink:NamedThing mannose-1-phosphate guanylyltransferase activity Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose. got7fsn_ti GDP-mannose pyrophosphorylase activity|GTP-mannose-1-phosphate guanylyltransferase activity|GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity|GTP:mannose-1-phosphate guanylyltransferase activity|guanosine 5'-diphospho-D-mannose pyrophosphorylase activity|guanosine diphosphomannose pyrophosphorylase activity|PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)|guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity|mannose 1-phosphate guanylyltransferase (guanosine triphosphate) Reactome:R-HSA-446221|EC:2.7.7.13|RHEA:15229|MetaCyc:2.7.7.13-RXN|KEGG_REACTION:R00885 molecular_function owl:Class
GO:0090595 biolink:NamedThing acetyl-CoA:L-lysine N6-acetyltransferase Catalysis of the reaction: L-lysine + acetyl-CoA = N6-acetyl-L-lysine + CoA + H(+). got7fsn_ti tb 2014-08-21T17:19:06Z molecular_function owl:Class
GO:0098795 biolink:NamedThing mRNA cleavage involved in gene silencing Cleavage of an mRNA occurring as part of the mechanism of gene silencing. got7fsn_ti biological_process owl:Class
GO:0043907 biolink:NamedThing Cys-tRNA(Pro) hydrolase activity Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro). got7fsn_ti Cys-tRNAPro hydrolase activity|Cys-tRNA(Pro) deacetylase activity EC:3.1.1.- molecular_function owl:Class
GO:1990609 biolink:NamedThing glutamate-cysteine ligase regulator activity Binds to and modulates the activity of glutamate-cysteine ligase. got7fsn_ti vw 2015-01-20T12:51:13Z molecular_function owl:Class
GO:0061721 biolink:NamedThing 6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-) The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-). got7fsn_ti dph 2015-07-01T09:20:08Z MetaCyc:PWY-7446 biological_process owl:Class
GO:0004037 biolink:NamedThing allantoicase activity Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea. got7fsn_ti allantoine amidinohydrolase activity|allantoate amidinohydrolase activity RHEA:11016|EC:3.5.3.4|MetaCyc:ALLANTOICASE-RXN|KEGG_REACTION:R02422 molecular_function owl:Class
GO:0003400 biolink:NamedThing regulation of COPII vesicle coating Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat. got7fsn_ti dph 2009-12-17T08:38:14Z biological_process owl:Class
GO:0060013 biolink:NamedThing righting reflex A reflex process in which an animal immediately tries to turn over after being placed in a supine position. got7fsn_ti righting response biological_process owl:Class
GO:0102927 biolink:NamedThing beta-chaconine rhamnosyltransferase activity Catalysis of the reaction: beta-chaconine + UDP-L-rhamnose = H+ + alpha-chaconine + UDP. got7fsn_ti MetaCyc:RXN-8883 molecular_function owl:Class
GO:0008218 biolink:NamedThing bioluminescence The production of light by certain enzyme-catalyzed reactions in cells. got7fsn_ti Wikipedia:Bioluminescence biological_process owl:Class
GO:0061625 biolink:NamedThing glycolytic process through fructose-1-phosphate The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH. got7fsn_ti dph 2014-04-29T13:04:10Z biological_process owl:Class
GO:0140238 biolink:NamedThing presynaptic endocytosis A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. got7fsn_ti https://github.com/geneontology/synapse/issues/230 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T07:33:55Z biological_process owl:Class
GO:0033464 biolink:NamedThing GGG codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a GGG codon. got7fsn_ti glycine tRNA Note that in the standard genetic code, GGG codes for glycine. molecular_function owl:Class
GO:0021926 biolink:NamedThing Golgi cell precursor proliferation The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex. got7fsn_ti biological_process owl:Class
GO:0052915 biolink:NamedThing 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine. got7fsn_ti KEGG_REACTION:R07234|RHEA:42740|MetaCyc:RXN-11574|EC:2.1.1.173 molecular_function owl:Class
GO:0035753 biolink:NamedThing maintenance of DNA trinucleotide repeats Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs. got7fsn_ti bf 2011-03-23T10:29:02Z biological_process owl:Class
GO:0050537 biolink:NamedThing mandelamide amidase activity Catalysis of the reaction: (R)-mandelamide + H(2)O = (R)-mandelate + NH(4)(+). got7fsn_ti mandelamide hydrolase activity|Pseudomonas mandelamide hydrolase activity KEGG_REACTION:R05783|RHEA:22876|EC:3.5.1.86|MetaCyc:3.5.1.86-RXN molecular_function owl:Class
GO:0019161 biolink:NamedThing diamine transaminase activity Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate. got7fsn_ti diamine-ketoglutaric transaminase activity|amine-ketoacid transaminase activity|diamine:2-oxoglutarate aminotransferase activity|amine transaminase activity|diamine aminotransferase activity EC:2.6.1.29|RHEA:18217|MetaCyc:DIAMTRANSAM-RXN molecular_function owl:Class
GO:0036000 biolink:NamedThing mucocyst A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion. got7fsn_ti bf 2011-09-06T01:32:17Z cellular_component owl:Class
GO:0034532 biolink:NamedThing 2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity Catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate. got7fsn_ti UM-BBD_reactionID:r0765|EC:5.3.99.- molecular_function owl:Class
GO:0047480 biolink:NamedThing UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine + ATP + D-alanyl-D-alanine = phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP. got7fsn_ti UDPacetylmuramoylpentapeptide synthetase activity|MurF synthetase activity|UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity|UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase activity|UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase activity|uridine diphosphoacetylmuramoylpentapeptide synthetase activity|UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase activity|UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D-alanyl-D-alanine ligase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming)|UDP-MurNAc-pentapeptide synthetase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase activity|UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase activity|UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase activity Note that the enzyme UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase also has UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (GO:0008766). MetaCyc:6.3.2.10-RXN|RHEA:16085|EC:6.3.2.10 molecular_function owl:Class
GO:0009026 biolink:NamedThing tagaturonate reductase activity Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH. got7fsn_ti TagUAR|D-altronate:NAD+ 3-oxidoreductase activity|altronic oxidoreductase activity|altronate oxidoreductase activity|tagaturonate dehydrogenase activity|D-tagaturonate reductase activity|altronate dehydrogenase activity MetaCyc:ALTRO-OXIDOREDUCT-RXN|KEGG_REACTION:R02555|RHEA:17813|EC:1.1.1.58 molecular_function owl:Class
GO:0097185 biolink:NamedThing cellular response to azide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus. got7fsn_ti pr 2011-11-16T10:04:41Z biological_process owl:Class
GO:0008480 biolink:NamedThing sarcosine dehydrogenase activity Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein. got7fsn_ti sarcosine:(acceptor) oxidoreductase (demethylating)|sarcosine:acceptor oxidoreductase (demethylating)|sarcosine N-demethylase activity|monomethylglycine dehydrogenase activity Note that this was EC:1.5.99.1. MetaCyc:SARCOSINE-DEHYDROGENASE-RXN|KEGG_REACTION:R00611|Reactome:R-HSA-6797913|EC:1.5.8.3|RHEA:19793 molecular_function owl:Class
GO:0047411 biolink:NamedThing 2-(acetamidomethylene)succinate hydrolase activity Catalysis of the reaction: 2 H2O + 2-(acetamidomethylene)succinate = CO2 + NH3 + succinate semialdehyde + acetate. got7fsn_ti 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)|alpha-(N-acetylaminomethylene)succinic acid hydrolase activity EC:3.5.1.29|RHEA:10432|MetaCyc:3.5.1.29-RXN molecular_function owl:Class
GO:0102823 biolink:NamedThing kaempferol-3-rhamnoside-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + kaempferol-3-rhamnoside <=> kaempferol 3-O-rhamnoside-7-O-glucoside + UDP. got7fsn_ti MetaCyc:RXN-8266 molecular_function owl:Class
GO:0047744 biolink:NamedThing chloridazon-catechol dioxygenase activity Catalysis of the reaction: 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O(2) = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+). got7fsn_ti 5-amino-4-chloro-2-(2,3-dihydroxyphenyl)-3(2H)-pyridazinone 1,2-oxidoreductase (decyclizing) RHEA:20449|KEGG_REACTION:R04602|EC:1.13.11.36|MetaCyc:CHLORIDAZON-CATECHOL-DIOXYGENASE-RXN molecular_function owl:Class
GO:0102975 biolink:NamedThing versiconal hemiacetal acetate reductase activity Catalysis of the reaction: versiconol acetate + NADP <=> versiconal hemiacetal acetate + NADPH. got7fsn_ti EC:1.1.1.353|MetaCyc:RXN-9490|RHEA:35695 molecular_function owl:Class
GO:0102863 biolink:NamedThing 1-18:3-2-18:1-phosphatidylcholine desaturase activity Catalysis of the reaction: 1-18:3-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor <=> 1-18:3-2-18:2-phosphatidylcholine + 2 H2O + an oxidized electron acceptor. got7fsn_ti MetaCyc:RXN-8330 molecular_function owl:Class
GO:0047369 biolink:NamedThing succinate-hydroxymethylglutarate CoA-transferase activity Catalysis of the reaction: (S)-3-hydroxy-3-methylglutarate + succinyl-CoA = 3-hydroxy-3-methyl-glutaryl-CoA + succinate. got7fsn_ti succinate:(S)-3-hydroxy-3-methylglutarate CoA-transferase activity|dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase activity|hydroxymethylglutarate coenzyme A-transferase activity MetaCyc:2.8.3.13-RXN|EC:2.8.3.13|RHEA:12284 molecular_function owl:Class
GO:0036381 biolink:NamedThing pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate. got7fsn_ti pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) activity|PdxST activity bf 2013-05-23T11:15:37Z KEGG_REACTION:R10089|RHEA:31507|EC:4.3.3.6|MetaCyc:RXN-11322 molecular_function owl:Class
GO:0047245 biolink:NamedThing N-acetylglucosaminyldiphosphoundecaprenol glucosyltransferase activity Catalysis of the reaction: N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP-D-glucose = beta-D-glucosyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol + UDP. got7fsn_ti UDP-glucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity|UDP-D-glucose:N-acetylglucosaminyl pyrophosphorylundecaprenol glucosyltransferase activity|uridine diphosphoglucose-acetylglucosaminylpyrophosphorylundecaprenol glucosyltransferase activity|UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity RHEA:20952|MetaCyc:2.4.1.188-RXN|EC:2.4.1.188 molecular_function owl:Class
GO:0000807 biolink:NamedThing Z chromosome The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females. got7fsn_ti Wikipedia:ZW_sex-determination_system cellular_component owl:Class
GO:0031487 biolink:NamedThing myosin XVII complex A myosin complex containing one or more class XVII myosin heavy chains and associated light chains. got7fsn_ti cellular_component owl:Class
GO:0050966 biolink:NamedThing detection of mechanical stimulus involved in sensory perception of pain The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal. got7fsn_ti perception of pain, detection of mechanical stimulus|perception of pain, sensory detection of mechanical stimulus|mechanical nociception|sensory detection of mechanical stimulus during perception of pain|perception of pain, sensory transduction of mechanical stimulus|sensory transduction of mechanical stimulus during perception of pain biological_process owl:Class
GO:0043306 biolink:NamedThing positive regulation of mast cell degranulation Any process that activates or increases the frequency, rate or extent of mast cell degranulation. got7fsn_ti up-regulation of mast cell degranulation|up regulation of mast cell degranulation|stimulation of mast cell degranulation|upregulation of mast cell degranulation|positive regulation of mast cell granule exocytosis|activation of mast cell degranulation biological_process owl:Class
GO:0102142 biolink:NamedThing [dermatan sulfate]-L-iduronyl 2-Osulfotransferase activity Catalysis of the reaction: 3'-phosphonato-5'-adenylyl sulfate + [dermatan]-alpha-L-iduronate <=> adenosine 3',5'-bismonophosphate + [dermatan-sulfate]-2-O-sulfo-alpha-L-iduronate. got7fsn_ti MetaCyc:RXN-11561 molecular_function owl:Class
GO:0036413 biolink:NamedThing histone H3-R26 citrullination The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3. got7fsn_ti histone H3 arginine 26 citrullination bf 2013-08-22T13:59:15Z biological_process owl:Class
GO:1990974 biolink:NamedThing actin-dependent nuclear migration The process whereby the centrosome is held at the cell center while the nucleus moves to the cell rear by actin retrograde flow resulting in the position of the centrosome between the nucleus and the leading edge of the cell. got7fsn_ti actin-dependent nuclear movement hjd 2016-06-22T19:17:02Z biological_process owl:Class
GO:0003853 biolink:NamedThing 2-methylacyl-CoA dehydrogenase activity Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor. got7fsn_ti branched-chain acyl-CoA dehydrogenase activity|2-methylbutanoyl-CoA:acceptor oxidoreductase activity|2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity|2-methyl branched chain acyl-CoA dehydrogenase activity MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN|EC:1.3.99.12|RHEA:13261 molecular_function owl:Class
GO:0042785 biolink:NamedThing evasion of host immune response via regulation of host cytokine network Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti active immune evasion via regulation of host cytokine network|active evasion of host immune response via regulation of host cytokine network|active evasion of immune response of other organism via regulation of cytokine network of other organism involved in symbiotic interaction|active immune evasion via modulation of host cytokine network GO:0051812 biological_process owl:Class
GO:0102440 biolink:NamedThing 3',4',5'-trimethylmyricetin 3-O-methyltransferase activity Catalysis of the reaction: 3',4',5'-trimethylmyricetin + S-adenosyl-L-methionine <=> 3,3',4',5'-tetramethylmyricetin + S-adenosyl-L-homocysteine + H+. got7fsn_ti MetaCyc:RXN-13918 molecular_function owl:Class
GO:0008011 biolink:NamedThing structural constituent of pupal chitin-based cuticle The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster. got7fsn_ti structural constituent of pupal cuticle molecular_function owl:Class
GO:1904125 biolink:NamedThing convergent extension involved in rhombomere morphogenesis Any convergent extension that is involved in rhombomere morphogenesis. got7fsn_ti dph 2015-04-10T21:12:50Z biological_process owl:Class
GO:1990943 biolink:NamedThing mating type region replication fork barrier binding Binding to the replication fork barrier found in the mating type region of fission yeast. got7fsn_ti RTS1 element binding|RTS1 barrier binding mah 2016-04-06T16:08:43Z molecular_function owl:Class
GO:0102399 biolink:NamedThing dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose <=> S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-alpha-D-glucose + H+. got7fsn_ti MetaCyc:RXN-13658 molecular_function owl:Class
GO:0031432 biolink:NamedThing titin binding Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. got7fsn_ti molecular_function owl:Class
GO:0002769 biolink:NamedThing natural killer cell inhibitory signaling pathway A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response. got7fsn_ti natural killer cell inhibitory signalling pathway|killer cell inhibitory receptor signaling pathway|NK cell inhibitory signaling pathway|Ly49 inhibitory receptor signaling pathway|inhibitory KIR signaling pathway biological_process owl:Class
GO:0043398 biolink:NamedThing HLH domain binding Binding to a Helix Loop Helix domain, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization. got7fsn_ti molecular_function owl:Class
GO:0071858 biolink:NamedThing corazonin receptor binding Binding to a corazonin receptor. got7fsn_ti mah 2010-09-10T03:23:40Z molecular_function owl:Class
GO:0071798 biolink:NamedThing response to prostaglandin D Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin D stimulus. got7fsn_ti response to prostaglandin D stimulus mah 2010-09-03T10:48:03Z biological_process owl:Class
GO:0030782 biolink:NamedThing (S)-tetrahydroprotoberberine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine. got7fsn_ti S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity|tetrahydroprotoberberine cis-N-methyltransferase activity MetaCyc:2.1.1.122-RXN|RHEA:12805|EC:2.1.1.122 molecular_function owl:Class
GO:0043274 biolink:NamedThing phospholipase binding Binding to a phospholipase. got7fsn_ti molecular_function owl:Class
GO:0102283 biolink:NamedThing 3-ketodihydrosphinganine (C20) reductase activity Catalysis of the reaction: C20 sphinganine(1+) + NADP <=> C20 3-dehydrosphinganine(1+) + NADPH + H+. got7fsn_ti MetaCyc:RXN-12642 molecular_function owl:Class
GO:0043212 biolink:NamedThing carbohydrate-exporting ABC transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out). got7fsn_ti carbohydrate-exporting ATPase activity https://github.com/geneontology/go-ontology/issues/17289 molecular_function owl:Class
GO:0003874 biolink:NamedThing 6-pyruvoyltetrahydropterin synthase activity Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate. got7fsn_ti 2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)|PTPS activity|2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity|6-pyruvoyl tetrahydrobiopterin synthase activity RHEA:22048|KEGG_REACTION:R04286|MetaCyc:4.2.3.12-RXN|Reactome:R-HSA-1474184|EC:4.2.3.12 molecular_function owl:Class
GO:0010067 biolink:NamedThing procambium histogenesis The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue. got7fsn_ti biological_process owl:Class
GO:0034296 biolink:NamedThing zygospore formation The process in which zygospores are formed. Zygospores are characteristic of the zygomycete fungi (phylum Zygomycota) thick-walled and darkly colored, and usually heavily ornamented as well, with many spines or ridges. It is formed between two specialized organs called suspensors, which are themselves usually heavily ornamented, one from each mating partner. The zygospore forms between them and then breaks away. got7fsn_ti biological_process owl:Class
GO:0042639 biolink:NamedThing telogen The resting phase of hair cycle. got7fsn_ti hair resting phase Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase. To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). biological_process owl:Class
GO:0034806 biolink:NamedThing benzo(a)pyrene 11,12-dioxygenase activity Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol. got7fsn_ti UM-BBD_reactionID:r1124|EC:1.13.11.- molecular_function owl:Class
GO:0033423 biolink:NamedThing CCA codon-amino acid adaptor activity A triplet codon-amino acid adaptor activity that recognizes a CCA codon. got7fsn_ti proline tRNA Note that in the standard genetic code, CCA codes for proline. molecular_function owl:Class
GO:0052604 biolink:NamedThing delta-tocopherol cyclase activity Catalysis of the reaction: 2-methyl-6-phytyl-1,4-benzoquinone = delta-tocopherol. got7fsn_ti KEGG_REACTION:R07503|RHEA:37987|MetaCyc:RXN-2561 molecular_function owl:Class
GO:0047280 biolink:NamedThing nicotinamide phosphoribosyltransferase activity Catalysis of the reaction: diphosphate + nicotinamide mononucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinamide. got7fsn_ti NMN synthetase activity|NMN pyrophosphorylase activity|nicotinamide mononucleotide pyrophosphorylase activity|nicotinamide-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity|nicotinamide mononucleotide synthetase activity|NMN diphosphorylase activity KEGG_REACTION:R01271|Reactome:R-HSA-197250|MetaCyc:2.4.2.12-RXN|EC:2.4.2.12|RHEA:16149 molecular_function owl:Class
GO:0106387 biolink:NamedThing 'de novo' GMP biosynthetic process The chemical reactions and pathways resulting in the formation of guanosine 5'-monophosphate (GMP) through an inosine 5'-monophosphate (IMP) intermediate. got7fsn_ti 'de novo' guanosine 5'-monophosphate biosynthetic process hjd 2021-07-07T17:27:01Z biological_process owl:Class
GO:0008864 biolink:NamedThing formyltetrahydrofolate deformylase activity Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+). got7fsn_ti 10-formyltetrahydrofolate amidohydrolase activity|formyltetrahydrofolate hydrolase activity|formyl-FH(4) hydrolase activity KEGG_REACTION:R00944|EC:3.5.1.10|MetaCyc:FORMYLTHFDEFORMYL-RXN|RHEA:19833 molecular_function owl:Class
GO:1990388 biolink:NamedThing xylem-to-phloem iron transport The directed movement of iron ions into the phloem from the xylem. got7fsn_ti tb 2014-05-30T21:06:50Z biological_process owl:Class
GO:0034231 biolink:NamedThing islet amyloid polypeptide processing The formation of mature islet amyloid polypeptide (IAPP) by posttranslational processing of pro-islet amyloid polypeptide (pro-IAPP). got7fsn_ti IAPP processing|islet amyloid peptide formation|IAPP formation|islet amyloid polypeptide formation|islet amyloid peptide processing biological_process owl:Class
GO:0098803 biolink:NamedThing respiratory chain complex Any protein complex that is part of a respiratory chain. got7fsn_ti cellular_component owl:Class
GO:0097075 biolink:NamedThing interferon regulatory factor 3-interferon regulatory factor 7 complex An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7. got7fsn_ti IRF3:IRF7 complex pr 2011-06-15T04:33:36Z cellular_component owl:Class
GO:0140623 biolink:NamedThing type I pilus assembly The assembly from its constituent parts of a type I pilus. got7fsn_ti type I fimbrial assembly|type I fimbriae biogenesis|type I fimbria biogenesis|T1P assembly|type I fimbrium assembly|type 1 pilus biogenesis|type I fimbriae assembly|type I fimbria assembly|type I fimbrial biogenesis|type I fimbrium biogenesis https://github.com/geneontology/go-ontology/issues/14469 pg 2021-03-10T12:23:20Z biological_process owl:Class
GO:0051617 biolink:NamedThing negative regulation of histamine uptake Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell. got7fsn_ti down regulation of histamine uptake|negative regulation of histamine import|downregulation of histamine uptake|down-regulation of histamine uptake biological_process owl:Class
GO:0032021 biolink:NamedThing NELF complex A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing. got7fsn_ti negative elongation factor complex cellular_component owl:Class
GO:0060584 biolink:NamedThing regulation of prostaglandin-endoperoxide synthase activity Any process that modulates the rate, frequency or prostaglandin-endoperoxide synthase activity. Prostaglandin-endoperoxide synthase activity is the catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O. got7fsn_ti regulation of (PG)H synthase activity|regulation of PG synthetase activity|regulation of fatty acid cyclooxygenase activity|regulation of prostaglandin synthetase activity dph 2009-05-08T02:08:37Z biological_process owl:Class
GO:0051697 biolink:NamedThing protein delipidation The breakage of covalent bonds to detach lipid groups from a protein. got7fsn_ti biological_process owl:Class
GO:0019810 biolink:NamedThing putrescine binding Binding to putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine. got7fsn_ti molecular_function owl:Class
GO:0140366 biolink:NamedThing galectin lattice A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids. got7fsn_ti pg 2019-07-25T19:35:05Z cellular_component owl:Class
GO:0098635 biolink:NamedThing protein complex involved in cell-cell adhesion Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. got7fsn_ti cellular_component owl:Class
GO:0034970 biolink:NamedThing histone H3-R2 methylation The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone. got7fsn_ti histone lysine H3 R2 methylation|histone H3 R2 methylation|histone H3R2me biological_process owl:Class
GO:0019509 biolink:NamedThing L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. got7fsn_ti methionine salvage from methylthioadenosine|methionine recycling|methionine salvage pathway|methionine regeneration MetaCyc:PWY-4361 biological_process owl:Class
GO:0042913 biolink:NamedThing group A colicin transmembrane transporter activity Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0010494 biolink:NamedThing cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. got7fsn_ti cytoplasmic mRNP granule|stress granule Wikipedia:Stress_granule cellular_component owl:Class
GO:0102708 biolink:NamedThing S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity Catalysis of the reaction: N-methyl-beta-alanine + S-adenosyl-L-methionine = H+ + N,N-dimethyl-beta-alanine + S-adenosyl-L-homocysteine. got7fsn_ti MetaCyc:RXN-6462 molecular_function owl:Class
GO:0008893 biolink:NamedThing guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate. got7fsn_ti penta-phosphate guanosine-3'-diphosphohydrolase activity|penta-phosphate guanosine-3'-pyrophosphohydrolase activity|guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity|guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity|guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity|PpGpp phosphohydrolase activity|PpGpp-3'-pyrophosphohydrolase activity|(ppGpp)ase activity RHEA:14253|MetaCyc:PPGPPSYN-RXN|EC:3.1.7.2 molecular_function owl:Class
GO:0047509 biolink:NamedThing (R)-dehydropantoate dehydrogenase activity Catalysis of the reaction: (R)-4-dehydropantoate + H(2)O + NAD(+) = (R)-3,3-dimethylmalate + 2 H(+) + NADH. got7fsn_ti (R)-4-dehydropantoate:NAD+ 4-oxidoreductase activity|D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine nucleotide (DPN+) oxidoreductase activity|D-aldopantoate dehydrogenase activity MetaCyc:R-DEHYDROPANTOATE-DEHYDROGENASE-RXN|RHEA:19349|EC:1.2.1.33|KEGG_REACTION:R03198 molecular_function owl:Class
GO:0075507 biolink:NamedThing entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome Viral penetration into the host nucleus where the where a viral capsid docks on the cytoplasmic side of the nuclear pore complex (NPC) and ejects the viral genome through the pore into the nucleoplasm. got7fsn_ti This mechanism is used by viruses such as Herpesvirales whose capsid is too large to enter the nuclear pore complex (NPC) pore. jl 2011-07-26T04:52:51Z biological_process owl:Class
GO:0071521 biolink:NamedThing Cdc42 GTPase complex A protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway. got7fsn_ti Ras1-Scd1-Scd2-Cdc42-Shk1 complex mah 2010-01-07T01:29:12Z cellular_component owl:Class
GO:0080048 biolink:NamedThing GDP-D-glucose phosphorylase activity Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP. got7fsn_ti RHEA:30387|EC:2.7.7.78|MetaCyc:RXN-12486 molecular_function owl:Class
GO:0047169 biolink:NamedThing galactarate O-hydroxycinnamoyltransferase activity Catalysis of the reaction: feruloyl-CoA + galactarate = 2-(E)-O-feruloyl-D-galactarate + CoA. got7fsn_ti galacturate hydroxycinnamoyltransferase activity|feruloyl-CoA:galactarate O-(hydroxycinnamoyl)transferase activity EC:2.3.1.130|MetaCyc:2.3.1.130-RXN|RHEA:12997|KEGG_REACTION:R03727 molecular_function owl:Class
GO:0102462 biolink:NamedThing quercetin 3-sophoroside 7-O-rhamnosyltransferase activity Catalysis of the reaction: quercetin 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP-L-rhamnose <=> quercetin 3-O-rhamnosyl(1->2)glucoside-7-O-rhamnoside + UDP + H+. got7fsn_ti MetaCyc:RXN-14011 molecular_function owl:Class
GO:0102907 biolink:NamedThing sesquisabinene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate(3-) <=> diphosphoric acid + sesquisabinene. got7fsn_ti MetaCyc:RXN-8622 molecular_function owl:Class
GO:1990656 biolink:NamedThing t-SNARE clustering The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies. got7fsn_ti sl 2015-02-25T00:18:33Z biological_process owl:Class
GO:0016058 biolink:NamedThing maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon. got7fsn_ti maintenance of rhodopsin mediated signaling|maintenance of rhodopsin mediated signalling biological_process owl:Class
GO:0033534 biolink:NamedThing verbascose biosynthetic process The chemical reactions and pathways resulting in the formation of verbascose, the pentasaccharide beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside. got7fsn_ti verbascose synthesis|verbascose anabolism|verbascose biosynthesis|verbascose formation biological_process owl:Class
GO:0031697 biolink:NamedThing beta-1 adrenergic receptor binding Binding to a beta-1 adrenergic receptor. got7fsn_ti beta-1 adrenergic receptor ligand molecular_function owl:Class
GO:0090474 biolink:NamedThing arg-arg specific dibasic protein processing Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein. got7fsn_ti tb 2012-10-01T10:42:30Z biological_process owl:Class
GO:0097686 biolink:NamedThing dinoflagellate apical horn A horn-shaped dinoflagellate apex found in thecate species. got7fsn_ti pr 2014-12-18T09:38:15Z cellular_component owl:Class
GO:0060367 biolink:NamedThing sagittal suture morphogenesis The process in which the sagittal suture is generated and organized. got7fsn_ti biological_process owl:Class
GO:0140446 biolink:NamedThing fumigermin biosynthetic process The chemical reactions and pathways resulting in the formation of fumigermin, an alpha-pyrone secondary metabolite found in some species of fungi such as Aspergillus fumigatus. got7fsn_ti fumigermin synthesis|fumigermin biosynthesis|fumigermin anabolism|fumigermin formation pg 2020-03-31T12:02:29Z biological_process owl:Class
GO:0034303 biolink:NamedThing myxospore formation The process in which differentiated, resting cells are formed, usually within a fruiting body by Myxobacteria. The myxospore is more resistant to high temperature, dessication, and UV than vegetative myxobacteria. got7fsn_ti biological_process owl:Class
GO:0001641 biolink:NamedThing group II metabotropic glutamate receptor activity A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. got7fsn_ti molecular_function owl:Class
GO:0019656 biolink:NamedThing glucose catabolic process to D-lactate and ethanol The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule. got7fsn_ti heterolactate fermentation|heterofermentative lactate fermentation|heterolactic fermentation|heterofermentative pathway|glucose fermentation to D-lactate and ethanol|heterofermentation MetaCyc:P122-PWY biological_process owl:Class
GO:0014868 biolink:NamedThing cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction. got7fsn_ti biological_process owl:Class
GO:0070068 biolink:NamedThing VAMP4-syntaxin-6-syntaxin-16-Vti1a complex A SNARE complex that contains VAMP4, syntaxin 6, syntaxin 16, and Vti1a (or orthologs thereof). got7fsn_ti SNARE complex (Vamp4, Stx6, Stx16, Vti1a)|Vamp4-Stx6-Stx16-Vti1a complex cellular_component owl:Class
GO:0140680 biolink:NamedThing histone H3-di/monomethyl-lysine-36 demethylase activity Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. got7fsn_ti histone H3K36me2 demethylase activity|histone H3K36me demethylase activity https://github.com/geneontology/go-ontology/issues/21089 pg 2021-07-08T14:12:22Z MetaCyc: RXN-8661|RHEA:42032|EC:1.14.11.27 molecular_function owl:Class
GO:0061842 biolink:NamedThing microtubule organizing center localization Any process in which the microtubule organizing center is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti MTOC localization|MTOC polarity|microtubule organizing center polarity biological_process owl:Class
GO:0102731 biolink:NamedThing D-myo-inositol (1,3,4,6)-tetrakisphosphate 2-kinase activity Catalysis of the reaction: myo-inositol 1,3,4,6-tetrakisphosphate(8-) + ATP = H+ + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ADP. got7fsn_ti MetaCyc:RXN-7185 molecular_function owl:Class
GO:0014731 biolink:NamedThing spectrin-associated cytoskeleton The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane. got7fsn_ti cellular_component owl:Class
GO:0061978 biolink:NamedThing mandibular condyle articular cartilage development The process whose specific outcome is the progression of mandibular joint condyle articular cartilage over time, from its formation to the mature structure. got7fsn_ti dph 2018-02-12T20:04:49Z biological_process owl:Class
GO:0050412 biolink:NamedThing cinnamate beta-D-glucosyltransferase activity Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP. got7fsn_ti uridine diphosphoglucose-cinnamate glucosyltransferase activity|UDP-glucose:trans-cinnamate beta-D-glucosyltransferase activity|cinnamate b-D-glucosyltransferase activity|cinnamate glucosyltransferase activity|UDPglucose:trans-cinnamate beta-D-glucosyltransferase activity|UDPG:t-cinnamate glucosyltransferase activity RHEA:13437|EC:2.4.1.177|MetaCyc:CINNAMATE-GLUCOSYLTRANSFERASE-RXN|KEGG_REACTION:R02256 molecular_function owl:Class
GO:0033751 biolink:NamedThing linoleate 8R-lipoxygenase Catalysis of the reaction: linoleate + O2 = (9Z,12Z)-(7S,8S)-dihydroxyoctadeca-9,12-dienoate. got7fsn_ti 7,8-linoleate diol synthase (bifunctional enzyme)|5,8-linoleate diol synthase (bifunctional enzyme)|linoleate diol synthase activity RHEA:22392 molecular_function owl:Class
GO:1990137 biolink:NamedThing plant seed peroxidase activity Catalysis of the reaction: R1H + R2OOH = R1OH + R2OH. got7fsn_ti peroxygenase activity tb 2013-07-03T12:49:20Z MetaCyc:RXN-11819|EC:1.11.2.3 molecular_function owl:Class
GO:0050332 biolink:NamedThing thiamine pyridinylase activity Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine. got7fsn_ti pyrimidine transferase activity|thiamin hydrolase activity|thiamin pyridinylase activity|thiamine pyridinolase activity|thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity|thiamin pyridinolase activity|thiamine hydrolase activity|thiaminase I activity|thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase activity RHEA:17697|MetaCyc:THIAMIN-PYRIDINYLASE-RXN|EC:2.5.1.2|KEGG_REACTION:R02863 molecular_function owl:Class
GO:0052640 biolink:NamedThing salicylic acid glucosyltransferase (glucoside-forming) activity Catalysis of the reaction: salicylic acid + UDP-glucose = salicylic acid 2-O-glucoside + UDP. got7fsn_ti UDP:glucose:SA glucosyltransferase (glucoside-forming) activity|UDP:glucose:salicylic acid glucosyltransferase (glucoside-forming) activity|salicylic acid glucosyltransferase activity|UDP:glucose:salicylate glucosyltransferase (glucoside-forming) activity|UDP:glucose:2-hydroxybenzoic acid glucosyltransferase (glucoside-forming) activity MetaCyc:RXN-11658|RHEA:62312 molecular_function owl:Class
GO:0048543 biolink:NamedThing phytochrome chromophore biosynthetic process The chemical reactions and pathways resulting in the formation of the phytochrome chromophore. The phytochrome chromophore is a linear tetrapyrrolic prosthetic group covalently attached to the large soluble protein phytochrome. Light absorption by the phytochrome chromophore triggers photoconversion between two spectrally distinct forms of the photoreceptor: Pr, the red light absorbing form, and Pfr, the far red light absorbing form. got7fsn_ti phytochrome chromophore anabolism|phytochrome chromophore formation|phytochrome chromophore synthesis|phytochrome chromophore biosynthesis biological_process owl:Class
GO:1990597 biolink:NamedThing AIP1-IRE1 complex A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein). got7fsn_ti AIP1-ERN1 complex|IRE1alpha-AIP1 complex|IRE1-DAB2IP complex bf 2015-01-05T15:14:35Z cellular_component owl:Class
GO:0047918 biolink:NamedThing GDP-mannose 3,5-epimerase activity Catalysis of the reaction: GDP-mannose = GDP-L-galactose. got7fsn_ti GDPmannose 3,5-epimerase activity|guanosine 5'-diphosphate D-mannose:guanosine 5'-diphosphate L-galactose epimerase activity|GDP-D-mannose:GDP-L-galactose epimerase activity MetaCyc:RXN-1882|EC:5.1.3.18|RHEA:11144 molecular_function owl:Class
GO:0009046 biolink:NamedThing zinc D-Ala-D-Ala carboxypeptidase activity Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine. got7fsn_ti D-alanyl-D-alanine-cleaving carboxypeptidase activity|DD-carboxypeptidase-transpeptidase activity|G enzyme|Zn(2+) G peptidase activity|D-alanyl-D-alanine hydrolase activity|Zn2+ G peptidase activity|DD-carboxypeptidase MetaCyc:3.4.17.14-RXN|EC:3.4.17.14 molecular_function owl:Class
GO:0047398 biolink:NamedThing dolichylphosphate-mannose phosphodiesterase activity Catalysis of the reaction: dolichyl beta-D-mannosyl phosphate + H2O = dolichol-phosphate + mannose. got7fsn_ti mannosylphosphodolichol phosphodiesterase activity|dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase activity EC:3.1.4.49|MetaCyc:3.1.4.49-RXN|RHEA:12989 molecular_function owl:Class
GO:0103015 biolink:NamedThing 4-amino-4-deoxy-L-arabinose transferase activity Catalysis of the reaction: (Kdo)2-lipid A + 2 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,poly-cis-undecaprenyl phosphate = (beta-L-Ara4N)2-(KDO)2-lipid A + 2 ditrans,polycis-undecaprenyl phosphate. got7fsn_ti RHEA:35371|MetaCyc:RXN0-2001|EC:2.4.2.43 molecular_function owl:Class
GO:0007633 biolink:NamedThing pattern orientation The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes. got7fsn_ti behavioural response to pattern orientation|behavioral response to pattern orientation biological_process owl:Class
GO:0048014 biolink:NamedThing Tie signaling pathway The series of molecular signals generated as a consequence of a Tie protein (a receptor) binding to one of its physiological ligands (an angiopoietin). got7fsn_ti Tie receptor signalling pathway|angiopoietin-Tie signaling pathway|Tek receptor signaling|Tie receptor signaling pathway|angiopoietin/Tie signaling pathway biological_process owl:Class
GO:0018464 biolink:NamedThing 3-hydroxypimeloyl-CoA dehydrogenase activity Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH. got7fsn_ti 3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity EC:1.1.1.259|KEGG_REACTION:R05305|RHEA:11168|UM-BBD_reactionID:r0196|MetaCyc:1.1.1.259-RXN molecular_function owl:Class
GO:0120275 biolink:NamedThing cerebral blood circulation The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products. got7fsn_ti telencephelon blood circulation|cerebrum blood circulation https://github.com/geneontology/go-ontology/issues/20107 krc 2020-10-20T19:13:51Z biological_process owl:Class
GO:0005954 biolink:NamedThing calcium- and calmodulin-dependent protein kinase complex An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins. got7fsn_ti CAMK2|calcium/calmodulin-dependent protein kinase complex|CaMKII cellular_component owl:Class
GO:0044530 biolink:NamedThing supraspliceosomal complex Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing. got7fsn_ti supraspliceosome complex jl 2012-03-15T03:33:08Z cellular_component owl:Class
GO:0042561 biolink:NamedThing alpha-amyrin synthase activity Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin. got7fsn_ti MetaCyc:RXN-8434 molecular_function owl:Class
GO:0018459 biolink:NamedThing carveol dehydrogenase activity Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH. got7fsn_ti (-)-trans-carveol dehydrogenase activity|(-)-trans-carveol:NADP+ oxidoreductase activity EC:1.1.1.243|KEGG_REACTION:R03114|MetaCyc:CARVEOL-DEHYDROGENASE-RXN|UM-BBD_reactionID:r0714|RHEA:13629 molecular_function owl:Class
GO:0004047 biolink:NamedThing aminomethyltransferase activity Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. got7fsn_ti protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity|glycine synthase activity|protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity|T-protein|glycine-cleavage system T-protein activity|tetrahydrofolate aminomethyltransferase activity|S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity MetaCyc:GCVT-RXN|RHEA:16945|Reactome:R-HSA-5693977|EC:2.1.2.10 molecular_function owl:Class
GO:0035049 biolink:NamedThing juvenile hormone acid methyltransferase activity Catalysis of the transfer of a methyl group to juvenile hormone acid. got7fsn_ti molecular_function owl:Class
GO:0106249 biolink:NamedThing Nicalin-NOMO complex A protein complex regulating Nodal signaling. Subunits are highly conserved in vertebrates and include Nicalin, NOMO and TMEM147. got7fsn_ti Nicalin-TMEM147-NOMO complex hjd 2020-02-18T17:51:43Z cellular_component owl:Class
GO:0009837 biolink:NamedThing fruit ripening, non-climacteric A fruit ripening process that does not involve a respiratory burst. got7fsn_ti biological_process owl:Class
GO:0031488 biolink:NamedThing myosin XVIII complex A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain. got7fsn_ti cellular_component owl:Class
GO:0102100 biolink:NamedThing mycothiol-arsenate ligase activity Catalysis of the reaction: arsenate + mycothiol <=> mycothiol-arsenate conjugate + H2O. got7fsn_ti RHEA:27349|EC:2.8.4.2|MetaCyc:RXN-11187 molecular_function owl:Class
GO:1990738 biolink:NamedThing pseudouridine 5'-phosphatase activity Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate. got7fsn_ti vw 2015-05-02T11:05:50Z EC:3.1.3.96|RHEA:10944 molecular_function owl:Class
GO:0035741 biolink:NamedThing activated CD4-positive, alpha-beta T cell proliferation The expansion of an activated CD4-positive, alpha-beta T cell population by cell division. got7fsn_ti bf 2011-03-17T02:18:39Z biological_process owl:Class
GO:0140414 biolink:NamedThing phosphopantetheine-dependent carrier activity Binding a substrate via a thioester at the terminal thiol of a covalentely linked phosphopantetheine prosthetic group and mediating protein-protein interactions with cognate enzymes for processing or offloading of the thiol-bound substrate. got7fsn_ti carrier protein activity pg 2020-01-14T16:15:04Z molecular_function owl:Class
GO:1901770 biolink:NamedThing daunorubicin catabolic process The chemical reactions and pathways resulting in the breakdown of daunorubicin. got7fsn_ti daunorubicin breakdown|daunorubicin degradation|daunorubicin catabolism yaf 2013-01-15T10:14:29Z biological_process owl:Class
GO:0035393 biolink:NamedThing chemokine (C-X-C motif) ligand 9 production The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti Monokine induced by gamma interferon production|CXCL9 production|MIG production bf 2010-03-23T10:03:20Z biological_process owl:Class
GO:0004617 biolink:NamedThing phosphoglycerate dehydrogenase activity Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. got7fsn_ti D- and L-HGA|3-phosphoglycerate dehydrogenase activity|3-phosphoglyceric acid dehydrogenase activity|phosphoglycerate oxidoreductase activity|alphaKG reductase activity|D-3-phosphoglycerate:NAD+ oxidoreductase activity|glycerate-1,3-phosphate dehydrogenase activity|glycerate 3-phosphate dehydrogenase activity|3PHP reductase activity|3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity|D-3-phosphoglycerate dehydrogenase activity|PGDH activity|3-phosphoglycerate:NAD+ 2-oxidoreductase activity|SerA|alpha-KG reductase activity|alpha-phosphoglycerate dehydrogenase activity|SerA 3PG dehydrogenase activity|phosphoglyceric acid dehydrogenase activity Reactome:R-HSA-977348|EC:1.1.1.95|MetaCyc:PGLYCDEHYDROG-RXN|RHEA:12641 molecular_function owl:Class
GO:0036333 biolink:NamedThing hepatocyte homeostasis Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules. got7fsn_ti bf 2012-09-05T10:17:07Z biological_process owl:Class
GO:0016600 biolink:NamedThing flotillin complex A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae. got7fsn_ti See also the cellular component term 'caveola ; GO:0005901'. cellular_component owl:Class
GO:0032537 biolink:NamedThing host-seeking behavior The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host. got7fsn_ti host-seeking behaviour biological_process owl:Class
GO:0043242 biolink:NamedThing negative regulation of protein-containing complex disassembly Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components. got7fsn_ti inhibition of protein complex disassembly|negative regulation of protein complex disassembly|downregulation of protein complex disassembly|down-regulation of protein complex disassembly|down regulation of protein complex disassembly biological_process owl:Class
GO:0030153 biolink:NamedThing bacteriocin immunity A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary. got7fsn_ti biological_process owl:Class
GO:0004425 biolink:NamedThing indole-3-glycerol-phosphate synthase activity Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. got7fsn_ti indoleglycerol phosphate synthase activity|indole-3-glycerophosphate synthase activity|1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)|1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]|indoleglycerol phosphate synthetase activity RHEA:23476|MetaCyc:IGPSYN-RXN|EC:4.1.1.48 molecular_function owl:Class
GO:0014841 biolink:NamedThing skeletal muscle satellite cell proliferation The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage. got7fsn_ti biological_process owl:Class
GO:1990115 biolink:NamedThing RNA polymerase III assembly The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex. got7fsn_ti DNA-directed RNA polymerase III complex assembly|RNA Polymerase III complex assembly rb 2013-05-31T21:49:19Z biological_process owl:Class
GO:0036369 biolink:NamedThing transcription factor catabolic process The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. got7fsn_ti transcription factor breakdown|sequence-specific DNA binding transcription factor catabolic process|transcription factor catabolism|proteasome-mediated transcription factor catabolism|transcription factor degradation bf 2012-10-05T10:53:55Z biological_process owl:Class
GO:0042865 biolink:NamedThing pyochelin catabolic process The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid). got7fsn_ti pyochelin catabolism|pyochelin breakdown|pyochelin degradation biological_process owl:Class
GO:0071102 biolink:NamedThing alpha4-beta1 integrin-paxillin complex A protein complex that consists of an alpha4-beta1 integrin complex bound to paxillin. got7fsn_ti ITGA4-ITGB1-PXN complex mah 2009-11-06T04:53:22Z cellular_component owl:Class
GO:0102880 biolink:NamedThing isobazzanene synthase activity Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> isobazzanene + diphosphoric acid. got7fsn_ti MetaCyc:RXN-8419 molecular_function owl:Class
GO:0061898 biolink:NamedThing all-trans retinoic acid 3,4-desaturase activity Catalysis of the reaction: all-trans-retinoic acid + 2 H(+) + O2 + 2 reduced [adrenodoxin] = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized [adrenodoxin]. got7fsn_ti dph 2017-06-12T15:01:23Z molecular_function owl:Class
GO:0075328 biolink:NamedThing formation of arbuscule for nutrient acquisition The assembly of an arbuscule, a fine, tree-like hyphal symbiont structure projected into the host cell for the purpose of obtaining nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti formation by symbiont of arbuscule for nutrient acquisition from host https://github.com/geneontology/go-ontology/issues/20305 Note that this term should not be used to annotate gene products of the host. It should only be used to annotate those gene products from the symbiont involved in this process. biological_process owl:Class
GO:0098820 biolink:NamedThing trans-synaptic protein complex A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes. got7fsn_ti cellular_component owl:Class
GO:0102207 biolink:NamedThing docosanoate omega-hydroxylase activity Catalysis of the reaction: docosanoate + O2 + reduced [NADPH--hemoprotein reductase] = 22-hydroxydocosanoate + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]. got7fsn_ti behenate omega-hydroxylase activity https://github.com/geneontology/go-ontology/issues/19925 MetaCyc:RXN-12155|RHEA:40079 molecular_function owl:Class
GO:0047672 biolink:NamedThing anthranilate N-benzoyltransferase activity Catalysis of the reaction: anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA. got7fsn_ti benzoyl-CoA:anthranilate N-benzoyltransferase MetaCyc:ANTHRANILATE-N-BENZOYLTRANSFERASE-RXN|RHEA:21600|KEGG_REACTION:R02453|EC:2.3.1.144 molecular_function owl:Class
GO:0098865 biolink:NamedThing modification by symbiont of host bicellular tight junctions The process in which an organism effects a change in the structure or function of its host bicellular tight junctions, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet. got7fsn_ti biological_process owl:Class
GO:0039721 biolink:NamedThing peristromal region viral factory A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses. got7fsn_ti PR bf 2013-12-19T15:54:00Z cellular_component owl:Class
GO:0043127 biolink:NamedThing negative regulation of 1-phosphatidylinositol 4-kinase activity Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase. got7fsn_ti down-regulation of 1-phosphatidylinositol 4-kinase activity|downregulation of 1-phosphatidylinositol 4-kinase activity|inhibition of 1-phosphatidylinositol 4-kinase activity|down regulation of 1-phosphatidylinositol 4-kinase activity|negative regulation of PI4K activity biological_process owl:Class
GO:0007225 biolink:NamedThing patched ligand maturation The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups. got7fsn_ti hh protein processing|patched ligand processing|Hedgehog protein processing biological_process owl:Class
GO:0043976 biolink:NamedThing histone H3-K79 acetylation The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone. got7fsn_ti histone H3 acetylation at K79|histone H3K79 acetylation biological_process owl:Class
CHEBI:18111 biolink:NamedThing got7fsn_ti owl:Class
SO:0000252 biolink:NamedThing got7fsn_ti owl:Class
BFO:0000023 biolink:NamedThing got7fsn_ti owl:Class
CHEBI:50906 biolink:NamedThing got7fsn_ti owl:Class
CHEBI:36080 biolink:NamedThing got7fsn_ti owl:Class
CHEBI:17843 biolink:NamedThing got7fsn_ti owl:Class
SO:0000253 biolink:NamedThing got7fsn_ti owl:Class
CHEBI:33699 biolink:NamedThing got7fsn_ti owl:Class
GOREL:0001019 biolink:NamedThing results_in_division_of got7fsn_ti use occurs_in|use occurs_in GOREL:0001019|GOREL:0001019 external|external results_in_division_of|results_in_division_of owl:ObjectProperty
RO:0000057 biolink:NamedThing has participant got7fsn_ti RO:0000057|RO:0000057 external|external has_participant|has_participant owl:ObjectProperty
RO:0012003 biolink:NamedThing acts on population of got7fsn_ti RO:0012003|RO:0012003 external|external acts_on_population_of|acts_on_population_of owl:ObjectProperty
RO:0002212 biolink:NamedThing negatively regulates got7fsn_ti RO:0002212|RO:0002212 external|external negatively_regulates|negatively_regulates owl:ObjectProperty
RO:0002211 biolink:NamedThing regulates got7fsn_ti RO:0002211|RO:0002211 external|external regulates|regulates owl:ObjectProperty
GOREL:0002004 biolink:NamedThing results_in_fission_of got7fsn_ti GOREL:0002004|GOREL:0002004 external|external results_in_fission_of|results_in_fission_of owl:ObjectProperty
RO:0002092 biolink:NamedThing happens during got7fsn_ti RO:0002092|RO:0002092 external|external happens_during|happens_during owl:ObjectProperty
RO:0002093 biolink:NamedThing ends_during got7fsn_ti RO:0002093|RO:0002093 external|external ends_during|ends_during owl:ObjectProperty
GOREL:0002002 biolink:NamedThing obsolete results_in_disassembly_of got7fsn_ti True|True GOREL:0002002|GOREL:0002002 results_in_disassembly_of|results_in_disassembly_of owl:ObjectProperty
RO:0002590 biolink:NamedThing results_in_disassembly_of got7fsn_ti RO:0002590|RO:0002590 external|external results_in_disassembly_of|results_in_disassembly_of owl:ObjectProperty
GOREL:0002001 biolink:NamedThing obsolete results_in_assembly_of got7fsn_ti True|True GOREL:0002001|GOREL:0002001 results_in_assembly_of|results_in_assembly_of owl:ObjectProperty
RO:0002588 biolink:NamedThing results_in_assembly_of got7fsn_ti RO:0002588|RO:0002588 external|external results_in_assembly_of|results_in_assembly_of owl:ObjectProperty
RO:0002592 biolink:NamedThing results in organization of got7fsn_ti RO:0002592|RO:0002592 external|external results_in_organization_of|results_in_organization_of owl:ObjectProperty
GOREL:0001006 biolink:NamedThing acts_on_population_of got7fsn_ti alters levels of Note that many annotation extensions use regulates_o_acts_on_population_of - should this be considered regulation of number of cells / cell homeostasis?|Note that many annotation extensions use regulates_o_acts_on_population_of - should this be considered regulation of number of cells / cell homeostasis? GOREL:0001006|GOREL:0001006 acts_on_population_of|acts_on_population_of owl:ObjectProperty
GOREL:0002007 biolink:NamedThing obsolete results_in_remodeling_of got7fsn_ti True|True GOREL:0002007|GOREL:0002007 results_in_remodeling_of|results_in_remodeling_of owl:ObjectProperty
RO:0002591 biolink:NamedThing results in remodeling of got7fsn_ti RO:0002591|RO:0002591 external|external results_in_remodeling_of|results_in_remodeling_of owl:ObjectProperty
RO:0002213 biolink:NamedThing positively regulates got7fsn_ti RO:0002213|RO:0002213 external|external positively_regulates|positively_regulates owl:ObjectProperty
GOREL:0012006 biolink:NamedThing results_in_maintenance_of got7fsn_ti GOREL:0012006|GOREL:0012006 external|external results_in_maintenance_of|results_in_maintenance_of owl:ObjectProperty
GOREL:0002006 biolink:NamedThing obsolete results_in_organization_of got7fsn_ti True|True GOREL:0002006|GOREL:0002006 results_in_organization_of|results_in_organization_of owl:ObjectProperty
OBO:go/extensions/ro_pending#results_in_connection_of biolink:NamedThing obsolete results_in_connection_of got7fsn_ti will be replaced by has_input|will be replaced by has_input True|True owl:ObjectProperty
RO:0012008 biolink:NamedThing results in fusion of got7fsn_ti RO:0012008|RO:0012008 external|external results_in_fusion_of|results_in_fusion_of owl:ObjectProperty
BFO:0000050 biolink:NamedThing part of got7fsn_ti BFO:0000050|BFO:0000050 external|external part_of|part_of owl:ObjectProperty
BFO:0000051 biolink:NamedThing has part got7fsn_ti BFO:0000051|BFO:0000051 external|external has_part|has_part owl:TransitiveProperty
GO:0036326 biolink:NamedThing got7fsn_ti True owl:Class
IAO:0000227 biolink:NamedThing got7fsn_ti
GOP:goslim_chembl biolink:NamedThing got7fsn_ti ChEMBL protein targets summary owl:AnnotationProperty
GO:1904804 biolink:NamedThing got7fsn_ti True owl:Class
GOP:goslim_drosophila biolink:NamedThing got7fsn_ti Drosophila GO slim owl:AnnotationProperty
GOP:goslim_pir biolink:NamedThing got7fsn_ti PIR GO slim owl:AnnotationProperty
GO:0072568 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052250 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072642 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990746 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052303 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010627 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061022 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007511 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902504 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042345 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019949 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902403 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035427 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019088 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051527 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045072 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042378 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901662 biolink:NamedThing quinone catabolic process The chemical reactions and pathways resulting in the breakdown of quinone. got7fsn_ti quinone cofactor catabolic process|quinone degradation|quinone cofactor catabolism|quinone cofactor breakdown|quinone cofactor degradation|quinone breakdown|quinone catabolism pr 2012-11-20T14:44:44Z GO:0042378 biological_process owl:Class
GO:0103115 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035634 biolink:NamedThing response to stilbenoid Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones. got7fsn_ti bf 2011-01-12T10:37:33Z biological_process owl:Class
GO:0070870 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070829 biolink:NamedThing obsolete heterochromatin maintenance OBSOLETE. The chromatin organization process that preserves heterochromatin in a stable functional or structural state. got7fsn_ti maintenance of heterochromatic silencing|maintenance of chromatin silencing|heterochromatin maintenance involved in chromatin silencing https://github.com/geneontology/go-ontology/issues/22013 This term was obsoleted because it is redundant with heterochromatin organization and assembly terms. mah 2009-07-23T04:14:49Z True GO:0070870|GO:0006344 biological_process owl:Class
GOP:goslim_pombe biolink:NamedThing got7fsn_ti Fission yeast GO slim owl:AnnotationProperty
GO:0006861 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901688 biolink:NamedThing got7fsn_ti True owl:Class
GOP:goslim_agr biolink:NamedThing got7fsn_ti AGR slim owl:AnnotationProperty
GO:0051830 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031793 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061020 biolink:NamedThing got7fsn_ti True owl:Class
GOP:goslim_yeast biolink:NamedThing got7fsn_ti Yeast GO slim owl:AnnotationProperty
GO:1905964 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097319 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098704 biolink:NamedThing carbohydrate import across plasma membrane The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti carbohydrate import into cell pr 2012-05-31T02:45:02Z GO:0097319 biological_process owl:Class
GO:1902469 biolink:NamedThing got7fsn_ti True owl:Class
GOP:gocheck_do_not_annotate biolink:NamedThing got7fsn_ti Term not to be used for direct annotation owl:AnnotationProperty
GO:0015162 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015084 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090608 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000130 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099168 biolink:NamedThing extrinsic component of postsynaptic specialization membrane of symmetric synapse The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti dos 2017-09-10T12:00:26Z cellular_component owl:Class
GOP:goslim_synapse biolink:NamedThing got7fsn_ti synapse GO slim owl:AnnotationProperty
GOP:goslim_generic biolink:NamedThing got7fsn_ti Generic GO slim owl:AnnotationProperty
GO:0012504 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010741 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001034 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:4930 biolink:NamedThing got7fsn_ti owl:Class
GOP:goslim_flybase_ribbon biolink:NamedThing got7fsn_ti FlyBase Drosophila GO ribbon slim owl:AnnotationProperty
GO:0003764 biolink:NamedThing got7fsn_ti True owl:Class
GOP:goslim_metagenomics biolink:NamedThing got7fsn_ti Metagenomics GO slim owl:AnnotationProperty
GO:0016786 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099140 biolink:NamedThing presynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. got7fsn_ti dos 2017-06-09T18:34:19Z biological_process owl:Class
GO:0032315 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043087 biolink:NamedThing regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. got7fsn_ti regulation of Ral GTPase activity|regulation of Cdc42 GTPase activity|regulation of Rap GTPase activity|regulation of Ran GTPase activity|regulation of Rac GTPase activity|regulation of Rab GTPase activity|regulation of ARF GTPase activity|regulation of Rho GTPase activity|regulation of Ras GTPase activity GO:0032315|GO:0032313|GO:0032314|GO:0043088|GO:0032318|GO:0032319|GO:0032312|GO:0032317|GO:0032316 biological_process owl:Class
GO:0032054 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048748 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072477 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002386 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071804 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042036 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017138 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016956 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044279 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098783 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016597 biolink:NamedThing amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents. got7fsn_ti molecular_function owl:Class
GO:0021857 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072416 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003735 biolink:NamedThing structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome. got7fsn_ti ribosomal RNA|ribosomal protein Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. GO:0003739|GO:0003742|GO:0003736|GO:0003737|GO:0003740|GO:0003738|GO:0003741 molecular_function owl:Class
GO:0009241 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904834 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043832 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043358 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000505 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044263 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051690 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002741 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002720 biolink:NamedThing positive regulation of cytokine production involved in immune response Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. got7fsn_ti stimulation of cytokine production during immune response|positive regulation of cytokine biosynthetic process involved in immune response|positive regulation of cytokine secretion involved in immune response|activation of cytokine production during immune response|positive regulation of cytokine production during immune response|up regulation of cytokine production during immune response|up-regulation of cytokine production during immune response|upregulation of cytokine production during immune response GO:0002744|GO:0002741 biological_process owl:Class
GO:0005843 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045371 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032737 biolink:NamedThing positive regulation of interleukin-14 production Any process that activates or increases the frequency, rate, or extent of interleukin-14 production. got7fsn_ti positive regulation of interleukin-14 biosynthetic process|up-regulation of interleukin-14 production|stimulation of interleukin-14 production|upregulation of interleukin-14 production|positive regulation of IL-14 production|activation of interleukin-14 production|up regulation of interleukin-14 production GO:0045371 biological_process owl:Class
GO:0072691 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045846 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002717 biolink:NamedThing positive regulation of natural killer cell mediated immunity Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity. got7fsn_ti positive regulation of NK cell activity|upregulation of natural killer cell mediated immunity|up-regulation of natural killer cell mediated immunity|up regulation of natural killer cell mediated immunity|positive regulation of natural killer cell activity|activation of natural killer cell mediated immunity|stimulation of natural killer cell mediated immunity|positive regulation of NK cell mediated immunity GO:0045846 biological_process owl:Class
GO:1902096 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044459 biolink:NamedThing obsolete plasma membrane part OBSOLETE. Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005886 True cellular_component owl:Class
GO:0090568 biolink:NamedThing got7fsn_ti True owl:Class
GOP:gocheck_do_not_manually_annotate biolink:NamedThing got7fsn_ti Term not to be used for direct manual annotation owl:AnnotationProperty
GO:0072401 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048124 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015238 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043119 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000490 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032321 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042963 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072623 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048123 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098959 biolink:NamedThing retrograde dendritic transport of mitochondrion The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse. got7fsn_ti retrograde dendrite transport of mitochondria biological_process owl:Class
GOP:goslim_aspergillus biolink:NamedThing got7fsn_ti Aspergillus GO slim owl:AnnotationProperty
GO:0030113 biolink:NamedThing got7fsn_ti True owl:Class
GOP:goslim_mouse biolink:NamedThing got7fsn_ti Mouse GO slim owl:AnnotationProperty
GO:0098546 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061636 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009818 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:3176 biolink:NamedThing got7fsn_ti owl:Class
GO:0071862 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072542 biolink:NamedThing protein phosphatase activator activity Binds to and increases the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. got7fsn_ti protein phosphatase type 2A activator activity|protein phosphatase type 1 activator activity|protein phosphatase 2 activator activity mah 2010-09-10T03:39:56Z GO:0072543|GO:0071862 molecular_function owl:Class
GO:0051277 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001747 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001077 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000787 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904696 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071896 biolink:NamedThing protein localization to adherens junction Any process in which a protein is transported to, and/or maintained at the adherens junction. got7fsn_ti protein localization in cell-cell adherens junction|protein localisation to adherens junction|protein localisation in cell-cell adherens junction|protein localisation to cell-cell adherens junction|protein localization in adherens junction|protein localization to cell-cell adherens junction|protein localisation in adherens junction mah 2010-09-14T04:03:27Z GO:1904696 biological_process owl:Class
GO:0060733 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045527 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010861 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030375 biolink:NamedThing obsolete thyroid hormone receptor coactivator activity OBSOLETE. The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself. got7fsn_ti thyroid hormone receptor activator activity|thyroid hormone receptor co-activator activity This term was obsoleted because it represented a gene product. True GO:0010861 molecular_function owl:Class
GO:0061717 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140142 biolink:NamedThing nucleocytoplasmic carrier activity Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein. got7fsn_ti nucleocytoplasmic importin/exportin activity|pre-miRNA transporter activity|miRNA transporter activity https://github.com/geneontology/go-ontology/issues/17399|https://github.com/geneontology/go-ontology/issues/14336 pg 2017-12-06T13:40:40Z GO:0090631|GO:0061717 molecular_function owl:Class
GO:0003763 biolink:NamedThing obsolete chaperonin ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts. got7fsn_ti chaperonin|chaperonin ATPase activity GO:0016887 This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. GO:0006457 True GO:0003766|GO:0003765|GO:0003764 molecular_function owl:Class
GO:0042266 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001141 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015237 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003740 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042237 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070011 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006946 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045280 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050576 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032519 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015678 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019189 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902519 biolink:NamedThing response to docetaxel trihydrate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a docetaxel trihydrate stimulus. got7fsn_ti response to docetaxel Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. dw 2013-12-02T09:44:04Z biological_process owl:Class
GO:0003698 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016955 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034065 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048637 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072556 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006947 biolink:NamedThing got7fsn_ti True owl:Class
GOP:goslim_candida biolink:NamedThing got7fsn_ti Candida GO slim owl:AnnotationProperty
OIO:SubsetProperty biolink:NamedThing subset_property got7fsn_ti owl:AnnotationProperty
GO:0052529 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032852 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072457 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905419 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010261 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098998 biolink:NamedThing extrinsic component of postsynaptic early endosome membrane The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti cellular_component owl:Class
GO:0052428 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042519 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042509 biolink:NamedThing regulation of tyrosine phosphorylation of STAT protein Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. got7fsn_ti regulation of tyrosine phosphorylation of Stat6 protein|regulation of tyrosine phosphorylation of Stat2 protein|regulation of tyrosine phosphorylation of Stat7 protein|regulation of tyrosine phosphorylation of Stat4 protein|regulation of tyrosine phosphorylation of Stat3 protein|regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein GO:0042525|GO:0042519|GO:0042522|GO:0042510|GO:0042528|GO:0042513|GO:0042516 biological_process owl:Class
NCBITaxon:4895 biolink:NamedThing got7fsn_ti owl:Class
GO:0052348 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000695 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075121 biolink:NamedThing got7fsn_ti True owl:Class
GO:0023033 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015781 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042260 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045377 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032739 biolink:NamedThing positive regulation of interleukin-16 production Any process that activates or increases the frequency, rate, or extent of interleukin-16 production. got7fsn_ti up regulation of interleukin-16 production|activation of interleukin-16 production|positive regulation of IL-16 production|upregulation of interleukin-16 production|stimulation of interleukin-16 production|positive regulation of interleukin-16 biosynthetic process|up-regulation of interleukin-16 production GO:0045377 biological_process owl:Class
GO:0001166 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902947 biolink:NamedThing regulation of tau-protein kinase activity Any process that modulates the frequency, rate or extent of tau-protein kinase activity. got7fsn_ti regulation of [Tau protein] kinase activity|regulation of tau-protein kinase I activity|regulation of tau protein kinase activity|regulation of tau-tubulin kinase activity|regulation of TPK|regulation of STK31|regulation of TPK I|regulation of GSK|regulation of TPK II|regulation of CDK5/p23|regulation of glycogen synthase kinase-3beta activity|regulation of cdk5/p20|regulation of tau-protein kinase II activity|regulation of TTK|regulation of ATP:tau-protein O-phosphotransferase activity|regulation of protein tau kinase activity|regulation of tau kinase activity|regulation of brain protein kinase PK40erk activity sjp 2014-05-02T08:43:27Z biological_process owl:Class
GO:0032022 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150194 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150191 biolink:NamedThing positive regulation of interleukin-32 production Any process that activates or increases the frequency, rate or extent of interleukin-32 production. got7fsn_ti positive regulation of interleukin-32 biosynthetic process|positive regulation of interleukin-32 secretion bc 2020-02-21T10:33:39Z GO:0150194 biological_process owl:Class
GO:0016288 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003770 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008321 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005085 biolink:NamedThing guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. got7fsn_ti Rho guanyl-nucleotide exchange factor activity|ARF guanyl-nucleotide exchange factor activity|Rho guanine nucleotide exchange factor|guanyl-nucleotide releasing factor|cAMP-dependent guanyl-nucleotide exchange factor activity|GDP-dissociation stimulator activity|Ran guanyl-nucleotide exchange factor activity|Rap guanyl-nucleotide exchange factor activity|GNRP|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Sar guanyl-nucleotide exchange factor activity|GEF|Ral guanyl-nucleotide exchange factor activity|Ras guanyl-nucleotide exchange factor activity|GDS|guanyl-nucleotide release factor activity|RhoGEF https://github.com/geneontology/go-ontology/issues/18749|https://github.com/geneontology/go-ontology/issues/18750 GO:0008433|GO:0005088|GO:0019839|GO:0005089|GO:0005086|GO:0016219|GO:0030676|GO:0017132|GO:0005087|GO:0008321|GO:0017034|GO:0017112|GO:0016220|GO:0005090 Reactome:R-HSA-9624845|Reactome:R-HSA-5623508|Reactome:R-HSA-5654413|Reactome:R-HSA-8850041|Reactome:R-HSA-5655241|Reactome:R-HSA-169904|Reactome:R-HSA-177945|Reactome:R-HSA-5654426|Reactome:R-HSA-2029451|Reactome:R-HSA-9665707|Reactome:R-HSA-5655347|Reactome:R-HSA-1225957|Reactome:R-HSA-170979|Reactome:R-HSA-8877612|Reactome:R-HSA-9607304|Reactome:R-HSA-8875568|Reactome:R-HSA-379048|Reactome:R-HSA-1168636|Reactome:R-HSA-186834|Reactome:R-HSA-3928651|Reactome:R-HSA-9640167|Reactome:R-HSA-418579|Reactome:R-HSA-9029158|Reactome:R-HSA-8876193|Reactome:R-HSA-399995|Reactome:R-HSA-6811429|Reactome:R-HSA-939265|Reactome:R-HSA-5694409|Reactome:R-HSA-8875318|Reactome:R-HSA-8877813|Reactome:R-HSA-8853307|Reactome:R-HSA-8877998|Reactome:R-HSA-418850|Reactome:R-HSA-8876616|Reactome:R-HSA-392195|Reactome:R-HSA-3928632|Reactome:R-HSA-419166|Reactome:R-HSA-210977|Reactome:R-HSA-8848618|Reactome:R-HSA-3928612|Reactome:R-HSA-389350|Reactome:R-HSA-2424477|Reactome:R-HSA-4093336|Reactome:R-HSA-5218850|Reactome:R-HSA-177938|Reactome:R-HSA-8877475|Reactome:R-HSA-8982637|Reactome:R-HSA-442273|Reactome:R-HSA-2029467|Reactome:R-HSA-416588|Reactome:R-HSA-8851899|Reactome:R-HSA-8851827|Reactome:R-HSA-3928592|Reactome:R-HSA-380073|Reactome:R-HSA-8876191|Reactome:R-HSA-109817|Reactome:R-HSA-3928633|Reactome:R-HSA-8877451|Reactome:R-HSA-9665404|Reactome:R-HSA-418856|Reactome:R-HSA-9665408|Reactome:R-HSA-1250463|Reactome:R-HSA-1250383|Reactome:R-HSA-5218839|Reactome:R-HSA-1250498|Reactome:R-HSA-2029445|Reactome:R-HSA-9660824|Reactome:R-HSA-416530|Reactome:R-HSA-9639286|Reactome:R-HSA-5623521|Reactome:R-HSA-5617816|Reactome:R-HSA-5637806|Reactome:R-HSA-2179407|Reactome:R-HSA-9670436|Reactome:R-HSA-109807|Reactome:R-HSA-5637808|Reactome:R-HSA-442314|Reactome:R-HSA-6807868|Reactome:R-HSA-5654402|Reactome:R-HSA-420883|Reactome:R-HSA-8964604|Reactome:R-HSA-749453|Reactome:R-HSA-9032067|Reactome:R-HSA-350769|Reactome:R-HSA-9672170|Reactome:R-HSA-392870|Reactome:R-HSA-6811414|Reactome:R-HSA-5654647|Reactome:R-HSA-5654618|Reactome:R-HSA-180687|Reactome:R-HSA-399938|Reactome:R-HSA-9666430|Reactome:R-HSA-203977|Reactome:R-HSA-5654392|Reactome:R-HSA-5655277|Reactome:R-HSA-1306972|Reactome:R-HSA-5654663|Reactome:R-HSA-156913|Reactome:R-HSA-9032798|Reactome:R-HSA-8876190|Reactome:R-HSA-2424476|Reactome:R-HSA-445064|Reactome:R-HSA-171026|Reactome:R-HSA-3928642|Reactome:R-HSA-5686071|Reactome:R-HSA-8876615|Reactome:R-HSA-114544|Reactome:R-HSA-9672163|Reactome:R-HSA-8877308|Reactome:R-HSA-8982640|Reactome:R-HSA-205039|Reactome:R-HSA-8875320|Reactome:R-HSA-5686318|Reactome:R-HSA-3965444|Reactome:R-HSA-392054|Reactome:R-HSA-3928628|Reactome:R-HSA-379044|Reactome:R-HSA-8877311|Reactome:R-HSA-2730840|Reactome:R-HSA-5672965|Reactome:R-HSA-9664991|Reactome:R-HSA-8877760|Reactome:R-HSA-8851877|Reactome:R-HSA-1433415|Reactome:R-HSA-442732|Reactome:R-HSA-825631|Reactome:R-HSA-9033292|Reactome:R-HSA-428917|Reactome:R-HSA-5654600|Reactome:R-HSA-5218829|Reactome:R-HSA-8876454|Reactome:R-HSA-428750|Reactome:R-HSA-9634418|Reactome:R-HSA-1433471|Reactome:R-HSA-428535|Reactome:R-HSA-8875591|Reactome:R-HSA-8876837|Reactome:R-HSA-751029|Reactome:R-HSA-9619803|Reactome:R-HSA-9703441|Reactome:R-HSA-9026891|Reactome:R-HSA-442291|Reactome:R-HSA-389348|Reactome:R-HSA-9666428|Reactome:R-HSA-194518|Reactome:R-HSA-2485180|Reactome:R-HSA-8876188|Reactome:R-HSA-354173|Reactome:R-HSA-1225951|Reactome:R-HSA-187746|Reactome:R-HSA-6811418|Reactome:R-HSA-5655326|Reactome:R-HSA-9665700|Reactome:R-HSA-9665009|Reactome:R-HSA-9695853|Reactome:R-HSA-194913 molecular_function owl:Class
GO:0052558 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008326 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052513 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016440 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048604 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072615 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061814 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000043 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036233 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903804 biolink:NamedThing glycine import across plasma membrane The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti glycine import|glycine import into cell bf 2012-05-11T01:16:45Z GO:0036233 biological_process owl:Class
GO:0045363 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032654 biolink:NamedThing regulation of interleukin-11 production Any process that modulates the frequency, rate, or extent of interleukin-11 production. got7fsn_ti regulation of IL-11 production|regulation of interleukin-11 biosynthetic process|regulation of interleukin-11 secretion GO:0045363|GO:0150169 biological_process owl:Class
GO:0051810 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000509 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030967 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036288 biolink:NamedThing response to ximelagatran Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. bf 2012-07-16T05:03:56Z biological_process owl:Class
GO:0031180 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048414 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000366 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046427 biolink:NamedThing positive regulation of receptor signaling pathway via JAK-STAT Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity. got7fsn_ti positive regulation of STAT protein nuclear translocation|positive regulation of STAT protein import into nucleus|stimulation of JAK-STAT cascade|activation of JAK-STAT cascade|up regulation of JAK-STAT cascade|up-regulation of JAK-STAT cascade|upregulation of JAK-STAT cascade GO:2000366 biological_process owl:Class
GO:0044707 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033682 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052526 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043789 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990123 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900042 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032743 biolink:NamedThing positive regulation of interleukin-2 production Any process that activates or increases the frequency, rate, or extent of interleukin-2 production. got7fsn_ti up-regulation of interleukin-2 production|upregulation of interleukin-2 production|activation of interleukin-2 production|stimulation of interleukin-2 production|positive regulation of interleukin-2 secretion|positive regulation of interleukin-2 biosynthetic process|up regulation of interleukin-2 production|positive regulation of IL-2 production GO:0045086|GO:1900042 biological_process owl:Class
GO:0039538 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030028 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030231 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015585 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031184 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072454 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072412 biolink:NamedThing obsolete detection of stimulus involved in mitotic cell cycle checkpoint OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a mitotic cell cycle checkpoint. got7fsn_ti mitotic cell cycle G1/S checkpoint sensor mechanism|mitotic cell cycle checkpoint sensor mechanism|detection of stimulus involved in mitotic cell cycle G1/S checkpoint|sensing involved in mitotic cell cycle checkpoint|mitotic cell cycle checkpoint sensor process|sensing involved in mitotic cell cycle G1/S checkpoint|mitotic cell cycle G1/S checkpoint sensor process https://github.com/geneontology/go-ontology/issues/20976 This term was obsoleted because it corresponds to a molecular function. mah 2010-12-08T03:48:57Z True GO:0072454|GO:0072472 biological_process owl:Class
GO:0006841 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030606 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000134 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019110 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015831 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032844 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048676 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051809 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032947 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150162 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150159 biolink:NamedThing negative regulation of interleukin-34 production Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-34 production. got7fsn_ti negative regulation of interleukin-34 biosynthetic process bc 2020-01-06T16:31:12Z GO:0150162 biological_process owl:Class
GO:0045388 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018382 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046768 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018372 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015682 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046954 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045032 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018055 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018018 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052306 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052265 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090467 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030605 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000370 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:28009 biolink:NamedThing got7fsn_ti owl:Class
GO:0005282 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905963 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051242 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008485 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044811 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018605 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045908 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090476 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015457 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045674 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044425 biolink:NamedThing obsolete membrane part OBSOLETE. Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0016020 True cellular_component owl:Class
NCBITaxon:3312 biolink:NamedThing got7fsn_ti owl:Class
GO:0003728 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033213 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015587 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035466 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052550 biolink:NamedThing got7fsn_ti True owl:Class
GO:0080055 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042513 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000442 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001718 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006822 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099064 biolink:NamedThing integral component of postsynaptic endosome membrane The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti cellular_component owl:Class
GO:0090039 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034243 biolink:NamedThing regulation of transcription elongation from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. got7fsn_ti regulation of RNA elongation from RNA polymerase II promoter|regulation of gene-specific transcription elongation from RNA polymerase II promoter GO:0090039 biological_process owl:Class
GO:0006916 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000983 biolink:NamedThing got7fsn_ti True owl:Class
GO:0055084 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052272 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030090 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002744 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046840 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017112 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007103 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031399 biolink:NamedThing regulation of protein modification process Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. got7fsn_ti biological_process owl:Class
GO:0006944 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022895 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018994 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051297 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015582 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031791 biolink:NamedThing got7fsn_ti True owl:Class
GO:0020029 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038050 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030025 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903957 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072519 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061505 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071229 biolink:NamedThing cellular response to acid chemical Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form. got7fsn_ti cellular response to oxoanion|cellular response to acid anion|cellular response to acid This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead. mah 2009-12-03T02:07:23Z biological_process owl:Class
GO:0005361 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045531 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032671 biolink:NamedThing regulation of interleukin-27 production Any process that modulates the frequency, rate, or extent of interleukin-27 production. got7fsn_ti regulation of interleukin-27 biosynthetic process|regulation of IL-27 production|regulation of interleukin-27 synthesis|regulation of interleukin-27 formation GO:0045531 biological_process owl:Class
GO:0047210 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900401 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030236 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001142 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098707 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051829 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009981 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015555 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901476 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048417 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001590 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044356 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140362 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017016 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045422 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032723 biolink:NamedThing positive regulation of connective tissue growth factor production Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production. got7fsn_ti up-regulation of connective tissue growth factor production|positive regulation of Fisp12 production|positive regulation of connective tissue growth factor biosynthetic process|activation of connective tissue growth factor production|positive regulation of hypertrophic chondrocyte-specific gene product 24 production|positive regulation of IGFBP8 production|positive regulation of Hcs24 production|stimulation of connective tissue growth factor production|positive regulation of CCN2 production|positive regulation of CTGF production|upregulation of connective tissue growth factor production|up regulation of connective tissue growth factor production GO:0045422 biological_process owl:Class
GO:0045410 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032755 biolink:NamedThing positive regulation of interleukin-6 production Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. got7fsn_ti upregulation of interleukin-6 production|positive regulation of IL-6 production|positive regulation of interleukin-6 biosynthetic process|activation of interleukin-6 production|positive regulation of interleukin-6 secretion|stimulation of interleukin-6 production|up regulation of interleukin-6 production|up-regulation of interleukin-6 production GO:2000778|GO:0045410 biological_process owl:Class
GO:0023032 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000396 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902470 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099516 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052549 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990287 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042687 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045421 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032683 biolink:NamedThing negative regulation of connective tissue growth factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production. got7fsn_ti negative regulation of CTGF production|negative regulation of CCN2 production|inhibition of connective tissue growth factor production|negative regulation of Fisp12 production|negative regulation of connective tissue growth factor biosynthetic process|negative regulation of hypertrophic chondrocyte-specific gene product 24 production|negative regulation of Hcs24 production|downregulation of connective tissue growth factor production|down regulation of connective tissue growth factor production|negative regulation of IGFBP8 production|down-regulation of connective tissue growth factor production GO:0045421 biological_process owl:Class
GO:0031971 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:4932 biolink:NamedThing got7fsn_ti owl:Class
GO:1904265 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036263 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044121 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072437 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051426 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090128 biolink:NamedThing regulation of synapse maturation Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. got7fsn_ti tb 2009-12-07T03:00:58Z biological_process owl:Class
GO:0019735 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016534 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097483 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902591 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008262 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005049 biolink:NamedThing nuclear export signal receptor activity Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein. got7fsn_ti exportin activity|importin-alpha export receptor activity|NES receptor|importin-alpha binding https://github.com/geneontology/go-ontology/issues/14336 GO:0008262 molecular_function owl:Class
GO:0043106 biolink:NamedThing got7fsn_ti True owl:Class
GO:0020017 biolink:NamedThing got7fsn_ti True owl:Class
GO:0023013 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031075 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045401 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052059 biolink:NamedThing got7fsn_ti True owl:Class
GO:0023045 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030045 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031790 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048274 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030306 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030069 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052305 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052535 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016820 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903990 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017073 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:4896 biolink:NamedThing got7fsn_ti owl:Class
GO:0043118 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030483 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019167 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050707 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071956 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070526 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002390 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016452 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905806 biolink:NamedThing regulation of synapse pruning Any process that modulates the frequency, rate or extent of synapse pruning. got7fsn_ti regulation of synapse elimination|regulation of synapse removal|regulation of synapse disassembly|regulation of synapse clearance tb 2017-01-11T22:03:15Z biological_process owl:Class
GO:0061601 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048422 biolink:NamedThing got7fsn_ti True owl:Class
GOP:goslim_plant biolink:NamedThing got7fsn_ti Plant GO slim owl:AnnotationProperty
GO:0034984 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016548 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048606 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902449 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005554 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048862 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001903 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051713 biolink:NamedThing negative regulation of cytolysis in other organism Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the cytolysis of cells in another organism. got7fsn_ti downregulation of cytolysis of cells of another organism|inhibition of cytolysis of cells of another organism|down regulation of cytolysis of cells of another organism|negative regulation of cytolysis of cells of another organism|negative regulation of cytolysis of cells of another, non-host, organism|down-regulation of cytolysis of cells of another organism GO:0001903 biological_process owl:Class
GO:0030503 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045418 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032718 biolink:NamedThing negative regulation of interleukin-9 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production. got7fsn_ti inhibition of interleukin-9 production|negative regulation of IL-9 production|down regulation of interleukin-9 production|downregulation of interleukin-9 production|down-regulation of interleukin-9 production|negative regulation of interleukin-9 biosynthetic process GO:0045418 biological_process owl:Class
GO:0033649 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098805 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004678 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009816 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032004 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009520 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006960 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098968 biolink:NamedThing neurotransmitter receptor transport postsynaptic membrane to endosome Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome. got7fsn_ti biological_process owl:Class
GO:0009285 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052302 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905743 biolink:NamedThing calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration. got7fsn_ti mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration|calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration dos 2016-12-06T10:53:17Z biological_process owl:Class
GO:0044119 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016047 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031678 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032846 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019733 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016976 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051813 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016069 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019986 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031512 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035587 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102022 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990282 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902707 biolink:NamedThing hexose catabolic process to ethanol The chemical reactions and pathways resulting in the breakdown of hexose to ethanol. got7fsn_ti solventogenesis|hexose breakdown to ethanol|hexose degradation to ethanol|hexose catabolism to ethanol tb 2014-02-19T21:33:08Z GO:1990282 biological_process owl:Class
GO:0032146 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043359 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008101 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140554 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044153 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009613 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000667 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018840 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018987 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042486 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005961 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036442 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000189 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072462 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042604 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052070 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010532 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010579 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042737 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:241407 biolink:NamedThing got7fsn_ti owl:Class
GO:0099148 biolink:NamedThing regulation of synaptic vesicle docking Any process that modulates the frequency, rate or extent of synaptic vesicle docking. got7fsn_ti dos 2017-07-05T13:10:10Z biological_process owl:Class
GO:0031792 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902538 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019952 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904209 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000343 biolink:NamedThing positive regulation of chemokine (C-X-C motif) ligand 2 production Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. got7fsn_ti positive regulation of chemokine (C-C motif) ligand 2 secretion|positive regulation of SCYB2 production|positive regulation of MIP2 production|positive regulation of MIP-2 production|positive regulation of CXCL2 production|positive regulation of CCL2 secretion mah 2011-02-01T11:57:20Z GO:1904209 biological_process owl:Class
GO:0098957 biolink:NamedThing anterograde axonal transport of mitochondrion The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. got7fsn_ti anterograde axon transport of mitochondria biological_process owl:Class
GO:0009393 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015242 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031193 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005772 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902468 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032955 biolink:NamedThing regulation of division septum assembly Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. got7fsn_ti regulation of division septum formation GO:1902468|GO:1901138 biological_process owl:Class
GO:0000273 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015635 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004944 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044234 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016960 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075007 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904361 biolink:NamedThing positive regulation of spore germination Any process that activates or increases the frequency, rate or extent of spore germination. got7fsn_ti activation of spore germination|positive regulation of spore germination on or near host|up regulation of spore germination|upregulation of spore germination|up-regulation of spore germination pf 2015-06-12T19:46:18Z GO:0075007 biological_process owl:Class
GO:0008383 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990118 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050711 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032575 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009122 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042224 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052289 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008102 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035411 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072445 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072442 biolink:NamedThing obsolete detection of stimulus involved in mitotic DNA replication checkpoint OBSOLETE. The series of events in which information about whether DNA replication is complete is received and converted into a molecular signal, contributing to a mitotic DNA replication checkpoint. got7fsn_ti S-M checkpoint sensor process|mitotic DNA replication checkpoint sensor process|mitotic DNA replication checkpoint sensor mechanism|detection of stimulus involved in S-M checkpoint|sensing involved in mitotic DNA replication checkpoint|sensing involved in S-M checkpoint|S-M checkpoint sensor mechanism https://github.com/geneontology/go-ontology/issues/20976 This term was obsoleted because it corresponds to a molecular function. mah 2010-12-08T05:12:49Z True GO:0072445 biological_process owl:Class
GO:0072619 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015287 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072634 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002380 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008857 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903310 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001160 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000926 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015354 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903991 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032895 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035432 biolink:NamedThing positive regulation of gluconate transmembrane transport Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. got7fsn_ti stimulation of gluconate transport|positive regulation of gluconate membrane transport|up-regulation of gluconate transport|up regulation of gluconate transport|upregulation of gluconate transport|positive regulation of gluconate transport|activation of gluconate transport|induction of gluconate transport bf 2010-04-08T10:39:58Z GO:0032895 biological_process owl:Class
GO:0042035 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072608 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005099 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005096 biolink:NamedThing GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. got7fsn_ti GAP activity|Ran GAP activity|Sar GAP activity|ARF GTPase activator activity|Rap GTPase activator activity|Rho GAP activity|Ral GAP activity|ARF GAP activity|Rac GTPase activator activity|Sar GTPase activator activity|Rho GTPase activator activity|Rab GAP activity|RanGAP|Ras GTPase activator activity|Rab GTPase activator activity|Rac GAP activity|Ral GTPase activator activity|Rap GAP activity|Ras GAP activity|Ran GTPase activator activity Note that the name Sar derives from 'secretion-associated, Ras-related'. GO:0005100|GO:0005098|GO:0005101|GO:0008060|GO:0046582|GO:0017123|GO:0030675|GO:0005097|GO:0005099 Reactome:R-HSA-4093339|Reactome:R-HSA-428533|Reactome:R-HSA-392513|Reactome:R-HSA-9624893|Reactome:R-HSA-416546|Reactome:R-HSA-8985594|Reactome:R-HSA-416559|Reactome:R-HSA-194922|Reactome:R-HSA-399935|Reactome:R-HSA-5638007|Reactome:R-HSA-428522 molecular_function owl:Class
GO:0000359 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000599 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009993 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048433 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000157 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:4891 biolink:NamedThing got7fsn_ti owl:Class
GO:0019924 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042493 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990367 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015236 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042090 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015403 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044429 biolink:NamedThing obsolete mitochondrial part OBSOLETE. Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. got7fsn_ti mitochondrial subcomponent|mitochondrion component Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005739 True NIF_Subcellular:sao666410040 cellular_component owl:Class
GO:0004887 biolink:NamedThing got7fsn_ti True owl:Class
GO:0120024 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902411 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019130 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052347 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032439 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050752 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032644 biolink:NamedThing regulation of fractalkine production Any process that modulates the frequency, rate, or extent of fractalkine production. got7fsn_ti regulation of CX3CL1 biosynthesis|regulation of CX3CL1 production|regulation of fractalkine biosynthetic process https://github.com/geneontology/go-ontology/issues/19254 GO:0050752 biological_process owl:Class
GO:2000021 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045878 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045880 biolink:NamedThing positive regulation of smoothened signaling pathway Any process that activates or increases the frequency, rate or extent of smoothened signaling. got7fsn_ti positive regulation of smoothened by patched|stimulation of smoothened signaling pathway|positive regulation of hh signaling pathway|positive regulation of hedgehog signaling pathway|upregulation of smoothened signaling pathway|activation of smoothened signaling pathway|positive regulation of smoothened signalling pathway|up-regulation of smoothened signaling pathway|up regulation of smoothened signaling pathway|positive regulation of smoothened receptor activity by patched GO:0045878 biological_process owl:Class
GO:0008621 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018821 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008491 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008490 biolink:NamedThing arsenite secondary active transmembrane transporter activity Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti arsenite porter activity GO:0008491 molecular_function owl:Class
GO:0061500 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006350 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052256 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006485 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001679 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030230 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072440 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044755 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098717 biolink:NamedThing pantothenate import across plasma membrane The directed movement of pantothenate from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti pantothenate import|pantothenate import into cell jl 2012-12-06T13:02:23Z GO:0044755|GO:1901688 biological_process owl:Class
GO:0000371 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050791 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043140 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008461 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008916 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009405 biolink:NamedThing obsolete pathogenesis OBSOLETE. The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism. got7fsn_ti virulence https://github.com/geneontology/go-ontology/issues/11057 This term was obsoleted because it does not describe a single, normal biological process; rather it is the effect of an interaction between two organisms, under specific conditions. GO:0052031|GO:0044003|GO:0052042 True biological_process owl:Class
GO:0045546 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072611 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070364 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016978 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000218 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072644 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004472 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009484 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009482 biolink:NamedThing obsolete ba3-type cytochrome c oxidase OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. got7fsn_ti ba3-type cytochrome c oxidase GO:0004129 This term was made obsolete because it describes a class of gene products rather than a molecular function. True GO:0009484 molecular_function owl:Class
GO:0003751 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044122 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099083 biolink:NamedThing retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0043623 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008007 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044421 biolink:NamedThing obsolete extracellular region part OBSOLETE. Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite. got7fsn_ti extracellular structure Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005576 True NIF_Subcellular:sao9117790637 cellular_component owl:Class
GO:0016950 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046734 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019906 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052330 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005279 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031081 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016291 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:8782 biolink:NamedThing got7fsn_ti owl:Class
GO:0004004 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022621 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015206 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031373 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903274 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903277 biolink:NamedThing negative regulation of sodium ion export across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion export across the plasma membrane. got7fsn_ti down-regulation of sodium export|down-regulation of sodium ion export|down regulation of sodium export|down regulation of sodium ion export|down-regulation of sodium ion export from cell|negative regulation of sodium export|inhibition of sodium ion export from cell|negative regulation of sodium ion export|downregulation of sodium ion export from cell|inhibition of sodium export|down regulation of sodium ion export from cell|inhibition of sodium ion export|negative regulation of sodium ion export from cell|downregulation of sodium ion export|downregulation of sodium export rl 2014-08-08T17:10:22Z GO:1903274 biological_process owl:Class
GO:0019565 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051317 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051316 biolink:NamedThing attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation. got7fsn_ti attachment of spindle microtubules to kinetochore during meiotic chromosome segregation|attachment of spindle microtubules to meiotic chromosome|attachment of spindle microtubules to kinetochore during meiosis GO:0051317 biological_process owl:Class
GO:0051529 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008274 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035326 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032862 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016455 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016931 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006830 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035258 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001670 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004297 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001728 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007082 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902451 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018017 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004976 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000816 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:3378 biolink:NamedThing got7fsn_ti owl:Class
GO:1900393 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004886 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098699 biolink:NamedThing structural constituent of presynaptic actin cytoskeleton The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton. got7fsn_ti dos 2017-06-09T18:33:07Z molecular_function owl:Class
GO:0048434 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052037 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017140 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008722 biolink:NamedThing got7fsn_ti True owl:Class
GO:0047737 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070010 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045381 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090477 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070751 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070755 biolink:NamedThing negative regulation of interleukin-35 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-35 production. got7fsn_ti inhibition of interleukin-35 production|down regulation of interleukin-35 production|downregulation of interleukin-35 production|down-regulation of interleukin-35 production|negative regulation of interleukin-35 biosynthetic process|negative regulation of IL-35 production mah 2009-06-23T01:34:54Z GO:0070751 biological_process owl:Class
GO:0042524 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016687 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015359 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048116 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046955 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004580 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044244 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015523 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015518 biolink:NamedThing arabinose:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in). got7fsn_ti arabinose:hydrogen symporter activity|arabinose efflux permease activity|arabinose efflux transmembrane transporter activity GO:0015523 molecular_function owl:Class
GO:0051487 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042114 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031239 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031237 biolink:NamedThing intrinsic component of periplasmic side of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor. got7fsn_ti intrinsic to external leaflet of plasma membrane, in periplasmic space|intrinsic to periplasmic side of plasma membrane GO:0031239 cellular_component owl:Class
GO:0009106 biolink:NamedThing lipoate metabolic process The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. got7fsn_ti lipoic acid metabolic process|lipoic acid metabolism|lipoate metabolism GO:0000273 biological_process owl:Class
GO:1903414 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903988 biolink:NamedThing iron ion export across plasma membrane The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region. got7fsn_ti ferrous iron export|ferrous iron export across plasma membrane|iron cation export|iron(2+) export An example of this is mouse ferroportin (symbol Slc40a1, UniProtKB identifier: Q9JHI9). rl 2014-09-03T13:01:37Z GO:1903414 biological_process owl:Class
GO:0052090 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042241 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072450 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006375 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007046 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000789 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015405 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035468 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150035 biolink:NamedThing regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. bc 2018-04-17T13:56:34Z biological_process owl:Class
GO:0072602 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015409 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035056 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006394 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905058 biolink:NamedThing calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. got7fsn_ti calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels dos 2016-03-18T12:31:59Z molecular_function owl:Class
GO:0044724 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051706 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031513 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032860 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032360 biolink:NamedThing got7fsn_ti True owl:Class
GO:0039660 biolink:NamedThing structural constituent of virion The action of a molecule that contributes to the structural integrity of a virion. got7fsn_ti viral matrix protein bf 2013-07-22T16:43:41Z molecular_function owl:Class
GO:0043037 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990345 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902452 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010699 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032779 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052275 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009053 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051374 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019737 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072456 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000665 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902765 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052293 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018088 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046750 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046760 biolink:NamedThing viral budding from Golgi membrane A viral budding that starts with formation of a membrane curvature in the host Golgi membrane. got7fsn_ti virus budding from Golgi membrane|virus budding from Golgi membrane by viral capsid envelopment|Golgi membrane viral budding|viral budding from Golgi membrane during viral capsid envelopment|Golgi membrane viral budding during viral capsid envelopment|virus budding from Golgi membrane during viral capsid envelopment|viral budding from Golgi membrane by viral capsid envelopment GO:0046750|GO:0046763 biological_process owl:Class
GO:0045382 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005716 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031007 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016800 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035972 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035973 biolink:NamedThing aggrephagy Selective degradation of protein aggregates by macroautophagy. got7fsn_ti bf 2011-08-09T09:53:40Z GO:0035972 biological_process owl:Class
GO:1990237 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902906 biolink:NamedThing proteasome storage granule assembly The aggregation, arrangement and bonding together of a set of components to form a proteasome storage granule. got7fsn_ti proteasome storage granule formation|PSG formation|PSG assembly|sequestration of proteasome core complex in proteasome storage granule https://github.com/geneontology/go-ontology/issues/20458 di 2014-04-16T01:59:41Z GO:1990237 biological_process owl:Class
GO:0051708 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098612 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009623 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052260 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150192 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060390 biolink:NamedThing regulation of SMAD protein signal transduction Any process that modulates the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. got7fsn_ti regulation of SMAD protein nuclear translocation|SMAD protein import into nucleus GO:0007184 biological_process owl:Class
GO:0030571 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006745 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006557 biolink:NamedThing S-adenosylmethioninamine biosynthetic process The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. got7fsn_ti S-adenosylmethioninamine formation|S-adenosylmethioninamine synthesis|S-adenosylmethioninamine anabolism|S-adenosylmethioninamine biosynthesis GO:0006745 biological_process owl:Class
GO:0008844 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070632 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045399 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032672 biolink:NamedThing regulation of interleukin-3 production Any process that modulates the frequency, rate, or extent of interleukin-3 production. got7fsn_ti regulation of interleukin-3 biosynthetic process|regulation of IL-3 production GO:0045399 biological_process owl:Class
GO:0001202 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000158 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052288 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034962 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009434 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000664 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007126 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075517 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042143 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035068 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052278 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052004 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990335 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015564 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902740 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032687 biolink:NamedThing negative regulation of interferon-alpha production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production. got7fsn_ti negative regulation of interferon-alpha secretion|down regulation of interferon-alpha production|negative regulation of interferon-alpha biosynthetic process|down-regulation of interferon-alpha production|downregulation of interferon-alpha production|inhibition of interferon-alpha production GO:0045355|GO:1902740 biological_process owl:Class
GO:0075127 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003898 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140045 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061839 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000013 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000008 biolink:NamedThing obsolete thioredoxin OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol. got7fsn_ti thioredoxin This term was made obsolete because it represents gene products. GO:0015036|GO:0003756 True GO:0000013 molecular_function owl:Class
GO:0048111 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019012 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031200 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044415 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051244 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004841 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150037 biolink:NamedThing regulation of calcium-dependent activation of synaptic vesicle fusion Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion. got7fsn_ti bc 2018-04-18T12:47:38Z biological_process owl:Class
GO:0044054 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004840 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034226 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004440 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018092 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018384 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005089 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050717 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042375 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043148 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042623 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901689 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905135 biolink:NamedThing biotin import across plasma membrane The directed movement of biotin from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti biotin import into cell|biotin import jl 2012-12-05T16:30:20Z GO:1901689|GO:0044756 biological_process owl:Class
GO:0015512 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008339 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000042 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031742 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009283 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015246 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900865 biolink:NamedThing chloroplast RNA modification Any RNA modification that takes place in chloroplast. got7fsn_ti RNA editing in chloroplast tb 2012-06-11T10:58:04Z biological_process owl:Class
GO:0052152 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009262 biolink:NamedThing deoxyribonucleotide metabolic process The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti deoxyribonucleotide metabolism GO:0009393|GO:0009122 biological_process owl:Class
GO:0006444 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017152 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030039 biolink:NamedThing obsolete DNA unwinding factor OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti DNA unwinding factor GO:0006268 This term was made obsolete because it does not represent a true molecular function. True GO:0017152 molecular_function owl:Class
GO:1904169 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072405 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043283 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036327 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043706 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045402 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003741 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001663 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002005 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003982 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070752 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016181 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048828 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001201 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005293 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019047 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050876 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097459 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008128 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018797 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042570 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019009 biolink:NamedThing got7fsn_ti True owl:Class
GO:0103024 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042111 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051644 biolink:NamedThing plastid localization Any process in which a plastid is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti plastid localisation|establishment and maintenance of plastid localization biological_process owl:Class
GO:0044400 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048276 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035389 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:147554 biolink:NamedThing got7fsn_ti owl:Class
GO:0072431 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031618 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033725 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071789 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001212 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018709 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052376 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071151 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051288 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051287 biolink:NamedThing NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. got7fsn_ti NAD+ or NADH binding|NAD or NADH binding|nicotinamide adenine dinucleotide binding GO:0051288 molecular_function owl:Class
GO:0032066 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035083 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030722 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007312 biolink:NamedThing oocyte nucleus migration involved in oocyte dorsal/ventral axis specification The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster. got7fsn_ti oocyte axis determination, establishment of position of nucleus|oocyte axis determination, establishment of localization of nucleus|establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination|establishment of oocyte nucleus localization during oocyte axis determination|establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification|nucleus positioning in oocyte during oocyte axis determination|oocyte nucleus migration during oocyte axis specification|establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification|oocyte nuclear migration during oocyte axis determination|establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification|oocyte nucleus positioning during oocyte axis determination|oocyte axis determination, oocyte nucleus migration|oocyte axis determination, oocyte nuclear migration|oocyte nucleus migration during oocyte axis determination|establishment of localization of oocyte nucleus during oocyte axis determination|oocyte axis determination, positioning of nucleus|oocyte axis determination, establishment of oocyte nucleus localization|establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification GO:0048126|GO:0030722|GO:0048128|GO:0008102 biological_process owl:Class
GO:0051808 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902589 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001022 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043205 biolink:NamedThing got7fsn_ti True owl:Class
GO:0039681 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070261 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048129 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070749 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007145 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090157 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031178 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018347 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905077 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032700 biolink:NamedThing negative regulation of interleukin-17 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. got7fsn_ti negative regulation of IL-17 production|downregulation of interleukin-17 production|down regulation of interleukin-17 production|negative regulation of CTLA-8 production|negative regulation of interleukin-17 biosynthetic process|inhibition of interleukin-17 production|negative regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion|negative regulation of interleukin-17 secretion GO:0045379|GO:1905077 biological_process owl:Class
GO:0018806 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006332 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007152 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035534 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035531 biolink:NamedThing regulation of chemokine (C-C motif) ligand 6 production Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6). got7fsn_ti regulation of chemokine (C-C motif) ligand 6 secretion|chemokine (C-C motif) ligand 6 secretion|regulation of CCL6 production bf 2010-05-07T10:22:51Z GO:0035534|GO:0035535 biological_process owl:Class
NCBITaxon:451866 biolink:NamedThing got7fsn_ti owl:Class
GO:0004091 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009565 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009844 biolink:NamedThing obsolete germination OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth. got7fsn_ti germination This term was made obsolete because it is a grouping term without biological significance. True GO:0009565 biological_process owl:Class
GO:0051739 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018349 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042041 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031197 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018370 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009456 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008182 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035549 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050703 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045043 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005970 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005969 biolink:NamedThing serine-pyruvate aminotransferase complex An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate. got7fsn_ti serine-pyruvate aminotransferase, type 2B complex|serine-pyruvate aminotransferase, type 1 complex GO:0005970 cellular_component owl:Class
GO:0010580 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033136 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044268 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030468 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044112 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045528 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032668 biolink:NamedThing regulation of interleukin-24 production Any process that modulates the frequency, rate, or extent of interleukin-24 production. got7fsn_ti regulation of IL-24 production|regulation of interleukin-24 biosynthetic process GO:0045528 biological_process owl:Class
GO:0042569 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048552 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901677 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010537 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004011 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008089 biolink:NamedThing anterograde axonal transport The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. got7fsn_ti anterograde axon cargo transport biological_process owl:Class
GO:0048187 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001107 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010382 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900174 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003353 biolink:NamedThing positive regulation of cilium movement Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. got7fsn_ti positive regulation of flagellum movement|positive regulation of microtubule-based flagellum movement|positive regulation of flagellar movement Note that we deem cilium and microtubule-based flagellum to be equivalent. dph 2009-12-03T10:16:10Z GO:1900174 biological_process owl:Class
GO:0046743 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035638 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901042 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905589 biolink:NamedThing positive regulation of L-arginine import across plasma membrane Any process that activates or increases the frequency, rate or extent of L-arginine import across plasma membrane. got7fsn_ti positive regulation of L-arginine import|upregulation of L-arginine import|up-regulation of L-arginine import into cell|upregulation of L-arginine import into cell|activation of L-arginine import|activation of L-arginine uptake|up regulation of L-arginine import|positive regulation of L-arginine uptake|up regulation of L-arginine uptake|activation of L-arginine import across plasma membrane|up-regulation of L-arginine uptake|upregulation of L-arginine uptake|positive regulation of L-arginine import into cell|up-regulation of L-arginine import|activation of L-arginine import into cell al 2012-06-25T12:27:24Z GO:1901042|GO:1902828 biological_process owl:Class
GO:0007226 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990288 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902698 biolink:NamedThing pentose catabolic process to butyrate The chemical reactions and pathways resulting in the breakdown of pentose to butyrate. got7fsn_ti pentose catabolism to butyrate|pentose breakdown to butyrate|pentose degradation to butyrate|acidogenesis tb 2014-02-19T18:28:28Z GO:1990288 biological_process owl:Class
GO:0016116 biolink:NamedThing carotenoid metabolic process The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. got7fsn_ti carotenoid metabolism biological_process owl:Class
GO:1902454 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033676 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044801 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032858 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098668 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097623 biolink:NamedThing potassium ion export across plasma membrane The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region. got7fsn_ti potassium ion export|potassium ion export from cell|potassium export across plasma membrane|potassium export https://github.com/geneontology/go-ontology/issues/14265 pr 2009-12-16T11:10:45Z GO:0098668|GO:0071435 biological_process owl:Class
GO:0060564 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019494 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010133 biolink:NamedThing proline catabolic process to glutamate The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate. got7fsn_ti proline breakdown to glutamate|proline oxidation|proline degradation to glutamate GO:0019494 MetaCyc:PWY-4561|MetaCyc:PROUT-PWY biological_process owl:Class
GO:0030384 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048739 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002506 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030247 biolink:NamedThing polysaccharide binding Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. got7fsn_ti polysaccharide assembly with MHC class II protein complex GO:0002506 molecular_function owl:Class
GO:0034261 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006674 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006673 biolink:NamedThing inositol phosphoceramide metabolic process The chemical reactions and pathways involving inositol phosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group. got7fsn_ti inositolphosphoceramide metabolism|inositol phosphorylceramide metabolism|inositol phosphorylceramide metabolic process GO:0006674 biological_process owl:Class
GO:0019963 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071992 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022820 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010536 biolink:NamedThing positive regulation of activation of Janus kinase activity Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. got7fsn_ti positive regulation of activation of JAK protein|positive regulation of activation of JAK2 kinase activity|positive regulation of activation of JAK1 protein|positive regulation of tyrosine phosphorylation of JAK1 protein|positive regulation of tyrosine phosphorylation of JAK protein|positive regulation of activation of JAK1 kinase activity|positive regulation of activation of JAK2 protein|positive regulation of tyrosine phosphorylation of JAK2 protein GO:0010535|GO:0010537 biological_process owl:Class
GO:0085028 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000318 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045534 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032710 biolink:NamedThing negative regulation of interleukin-26 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production. got7fsn_ti down-regulation of interleukin-26 production|inhibition of interleukin-26 production|down regulation of interleukin-26 production|downregulation of interleukin-26 production|negative regulation of IL-26 production|negative regulation of interleukin-26 biosynthetic process GO:0045534 biological_process owl:Class
GO:0045373 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006594 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099132 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090456 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090517 biolink:NamedThing L-lysine transmembrane import into vacuole The directed movement of L-lysine into the vacuole across the vacuolar membrane. got7fsn_ti lysine transmembrane import into vacuole|vacuolar lysine import tb 2012-09-24T14:12:46Z GO:0090456 biological_process owl:Class
GO:0051832 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000046 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071780 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052285 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990337 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043389 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010388 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003745 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001624 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004959 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016292 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017104 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019591 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051157 biolink:NamedThing arabitol catabolic process The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. got7fsn_ti arabitol catabolism|arabitol utilization|arabitol degradation|arabitol breakdown GO:0019591 biological_process owl:Class
GO:0043109 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048430 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030013 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010551 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003076 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016932 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098748 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008642 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052166 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902377 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099037 biolink:NamedThing anchored component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. got7fsn_ti cellular_component owl:Class
GO:0042829 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008639 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051834 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016450 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043191 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004688 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051811 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045536 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046420 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045675 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042518 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904439 biolink:NamedThing negative regulation of iron ion import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane. got7fsn_ti negative regulation of ferrous iron import into cell|down regulation of ferrous iron import across plasma membrane|negative regulation of ferrous iron import across plasma membrane|down-regulation of ferrous iron import across plasma membrane|down regulation of ferrous ion import into cell|downregulation of ferrous iron import across plasma membrane|inhibition of ferrous ion import into cell|inhibition of ferrous iron import across plasma membrane|downregulation of ferrous ion import into cell|down-regulation of ferrous ion import into cell|negative regulation of ferrous ion import into cell rl 2015-07-06T13:49:58Z GO:1903990 biological_process owl:Class
GO:0018374 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051852 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990945 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072403 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072394 biolink:NamedThing obsolete detection of stimulus involved in cell cycle checkpoint OBSOLETE. The series of events in which information about a biological process or quality is received and converted into a molecular signal, contributing to a cell cycle checkpoint. got7fsn_ti detection of stimulus involved in G2/M transition checkpoint|G2/M transition checkpoint sensor mechanism|detection of stimulus involved in G1/S transition checkpoint|cell cycle checkpoint sensor mechanism|G1/S transition checkpoint sensor process|sensing involved in G2/M transition checkpoint|G1/S transition checkpoint sensor mechanism|sensing involved in G1/S transition checkpoint|cell cycle checkpoint sensor process|sensing involved in cell cycle checkpoint|G2/M transition checkpoint sensor process https://github.com/geneontology/go-ontology/issues/20976 This term was obsoleted because it corresponds to a molecular function. mah 2010-12-08T02:55:56Z True GO:0072403|GO:0072406 biological_process owl:Class
GO:0042347 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901223 biolink:NamedThing negative regulation of NIK/NF-kappaB signaling Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling. got7fsn_ti down-regulation of NIK/NF-kappaB cascade|down regulation of p52-dependent NF-kappaB signaling|inhibition of noncanonical NF-kappaB signaling|downregulation of p52-dependent NF-kappaB signaling|down-regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|downregulation of NIK/NF-kappaB cascade|negative regulation of NF-kappaB import into nucleus|down-regulation of non-canonical NF-KB signaling|inhibition of p52-dependent NF-kappaB signaling|negative regulation of noncanonical NF-kappaB signaling|down regulation of noncanonical NF-kappaB signaling|inhibition of NIK/NF-kappaB cascade|inhibition of non-canonical NF-KB signaling|down-regulation of p52-dependent NF-kappaB signaling|negative regulation of non-canonical NF-KB signaling|down-regulation of noncanonical NF-kappaB signaling|down regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|negative regulation of NIK/NF-kappaB cascade|down regulation of NIK/NF-kappaB cascade|negative regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|downregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway|downregulation of non-canonical NF-KB signaling|downregulation of noncanonical NF-kappaB signaling|negative regulation of p52-dependent NF-kappaB signaling|inhibition of noncanonical nuclear factor kappaB (NF-kappaB) pathway|down regulation of non-canonical NF-KB signaling hjd 2012-08-06T20:27:39Z GO:0042347 biological_process owl:Class
GO:0045395 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007457 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043166 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048595 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001038 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035536 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036347 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009857 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042871 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042222 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006443 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010533 biolink:NamedThing regulation of activation of Janus kinase activity Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it. got7fsn_ti regulation of activation of JAK1 protein|regulation of activation of JAK2 kinase activity|regulation of activation of JAK1 kinase activity|regulation of tyrosine phosphorylation of JAK2 protein|regulation of activation of JAK2 protein|regulation of tyrosine phosphorylation of JAK1 protein|regulation of tyrosine phosphorylation of JAK protein|regulation of activation of JAK protein GO:0010532|GO:0010534 biological_process owl:Class
GO:0031199 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075145 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004296 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045359 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001589 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046531 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008394 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010281 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043080 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017123 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035104 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052279 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990290 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052539 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019223 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018087 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004696 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075060 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000503 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075061 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006330 biolink:NamedThing obsolete single-stranded DNA binding OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti single-stranded DNA binding GO:0003697 This term was made obsolete because it represents a molecular function and not a biological process. True GO:0006332|GO:0006331 biological_process owl:Class
GO:0099061 biolink:NamedThing integral component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti cellular_component owl:Class
GO:0051578 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030044 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030040 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017155 biolink:NamedThing obsolete sodium:hydrogen antiporter regulator activity OBSOLETE. This term was not defined before being made obsolete. got7fsn_ti sodium:proton antiporter regulator|sodium:hydrogen antiporter regulator activity This term was made obsolete because it represents a biological process. True GO:0030040 molecular_function owl:Class
GO:0046605 biolink:NamedThing regulation of centrosome cycle Any process that modulates the frequency, rate or extent of the centrosome cycle, the processes of centrosome duplication and separation. got7fsn_ti biological_process owl:Class
GO:0036144 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070627 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901549 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006899 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098693 biolink:NamedThing regulation of synaptic vesicle cycle Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. got7fsn_ti dos 2017-03-21T16:06:48Z biological_process owl:Class
GO:0045084 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022892 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090469 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990122 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098713 biolink:NamedThing leucine import across plasma membrane The directed movement of leucine from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti leucine import into cell|L-leucine import into cell mah 2013-06-12T12:27:47Z GO:1990122 biological_process owl:Class
GO:1903802 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903273 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150171 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032734 biolink:NamedThing positive regulation of interleukin-11 production Any process that activates or increases the frequency, rate, or extent of interleukin-11 production. got7fsn_ti stimulation of interleukin-11 production|up-regulation of interleukin-11 production|positive regulation of interleukin-11 secretion|upregulation of interleukin-11 production|up regulation of interleukin-11 production|activation of interleukin-11 production|positive regulation of IL-11 production|positive regulation of interleukin-11 biosynthetic process GO:0045365|GO:0150171 biological_process owl:Class
GO:0001611 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032853 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004684 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015268 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090702 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015037 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044744 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045075 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032655 biolink:NamedThing regulation of interleukin-12 production Any process that modulates the frequency, rate, or extent of interleukin-12 production. got7fsn_ti regulation of NKSF production|regulation of CLMF production|regulation of interleukin-12 biosynthetic process|regulation of IL-12 production|regulation of interleukin-12 secretion GO:0045075|GO:2001182 biological_process owl:Class
GO:0016928 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031190 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051528 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008647 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009621 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006008 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043735 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902419 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004870 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098844 biolink:NamedThing postsynaptic endocytic zone membrane The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta. got7fsn_ti cellular_component owl:Class
GO:0045394 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032706 biolink:NamedThing negative regulation of interleukin-22 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production. got7fsn_ti down regulation of interleukin-22 production|down-regulation of interleukin-22 production|inhibition of interleukin-22 production|downregulation of interleukin-22 production|negative regulation of IL-22 production|negative regulation of interleukin-22 biosynthetic process GO:0045394 biological_process owl:Class
GO:0005333 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102016 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015413 biolink:NamedThing ABC-type nickel transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in). got7fsn_ti nickel transporting ATPase activity|nickel ABC transporter|nickel porter activity|ATPase-coupled nickel transmembrane transporter activity|ATP-dependent nickel transmembrane transporter activity|nickel ABC transporter activity|nickel-transporting ATPase activity GO:0102016 MetaCyc:3.6.3.24-RXN|EC:7.2.2.11|MetaCyc:ABC-20-RXN|RHEA:15557 molecular_function owl:Class
GO:0047226 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150193 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018843 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000496 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008325 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048131 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031181 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010687 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016948 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001213 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010107 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045396 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032667 biolink:NamedThing regulation of interleukin-23 production Any process that modulates the frequency, rate, or extent of interleukin-23 production. got7fsn_ti regulation of IL-23 biosynthetic process|regulation of interleukin-23 biosynthetic process|regulation of interleukin-23 biosynthesis|regulation of IL-23 production|regulation of interleukin-23 anabolism|regulation of interleukin-23 formation|regulation of interleukin-23 synthesis GO:0045396 biological_process owl:Class
GO:0043347 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048413 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072616 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050724 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016958 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052824 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003771 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003767 biolink:NamedThing obsolete co-chaperone activity OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity. got7fsn_ti co-chaperone activity This term was made obsolete because it represents a class of gene products rather than a molecular function. GO:0044183|GO:0051087|GO:0006457 True GO:0003769|GO:0003770|GO:0003771|GO:0003768 molecular_function owl:Class
GO:0015610 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015430 biolink:NamedThing ABC-type glycerol-3-phosphate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in). got7fsn_ti ATPase-coupled glycerol-3-phosphate transmembrane transporter activity|ATPase-coupled glycerol-2-phosphate transmembrane transporter activity|glycerol-3-phosphate ABC transporter|glycerol phosphate-importing ATPase activity|ATP-dependent glycerol-2-phosphate transmembrane transporter activity|glycerol-2-phosphate-transporting ATPase activity|glycerol-phosphate porter activity|ABC-type glycerol 3-phosphate transporter|glycerol-3-phosphate-transporting ATPase https://github.com/geneontology/go-ontology/issues/17164 GO:0015610|GO:0070812 MetaCyc:3.6.3.20-RXN|RHEA:21668|EC:7.6.2.10 molecular_function owl:Class
GO:0072486 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045083 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052189 biolink:NamedThing obsolete modulation by symbiont of defense-related host cell wall callose deposition OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by symbiont of defense-related host callose deposition|modulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction|modulation by organism of defense-related callose deposition of other organism involved in symbiotic interaction This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. True GO:0052285|GO:0052090|GO:0052310 biological_process owl:Class
GO:0048126 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003739 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001023 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006320 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150123 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035140 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017068 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043074 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150127 biolink:NamedThing regulation of interleukin-33 production Any process that modulates the frequency, rate or extent of interleukin-33 production. got7fsn_ti regulation of interleukin-33 secretion|regulation of interleukin-33 biosynthetic process bc 2019-12-03T05:54:03Z GO:0150123|GO:0150130 biological_process owl:Class
GO:0001013 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035055 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048024 biolink:NamedThing regulation of mRNA splicing, via spliceosome Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. got7fsn_ti regulation of nuclear mRNA splicing via U2-type spliceosome|regulation of nuclear mRNA splicing, via spliceosome|regulation of pre-mRNA splicing GO:0035055 biological_process owl:Class
GO:0008640 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032854 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990925 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001052 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075501 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001159 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003758 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030872 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990759 biolink:NamedThing got7fsn_ti True owl:Class
GO:0103095 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005349 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015604 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904454 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042681 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051227 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043019 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046913 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018714 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048415 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019041 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002216 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000169 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005162 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015458 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:554915 biolink:NamedThing got7fsn_ti owl:Class
GO:0070363 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033680 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009540 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015590 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000441 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016809 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034712 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033224 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005748 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099146 biolink:NamedThing intrinsic component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to postsynaptic specialization membrane dos 2017-07-05T10:43:24Z cellular_component owl:Class
GO:0006093 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004562 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022891 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071157 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051441 biolink:NamedThing obsolete positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle OBSOLETE. Any process that activates, maintains or increases the rate of ubiquitin ligase activity during the meiotic cell cycle. got7fsn_ti meiotic anaphase promoting complex activation|activation of ubiquitin ligase activity of anaphase promoting complex during meiotic cell cycle|meiotic APC activator|meiotic anaphase promoting complex activator|meiotic anaphase-promoting complex activator|APC activation during meiotic cell cycle|activation of anaphase-promoting complex activity involved in meiotic cell cycle|anaphase promoting complex activation during meiotic cell cycle|meiotic SCF complex activator|meiotic ubiquitin ligase activator|activation of ubiquitin ligase activity of anaphase-promoting complex during meiotic cell cycle|anaphase-promoting complex activation during meiotic cell cycle|activation of ubiquitin ligase activity of APC during meiotic cell cycle|up regulation of ubiquitin ligase activity during meiotic cell cycle|positive regulation of ubiquitin-protein ligase activity during meiotic cell cycle|activation of ubiquitin ligase activity during meiotic cell cycle|stimulation of ubiquitin ligase activity during meiotic cell cycle|positive regulation of ubiquitin ligase activity during meiotic cell cycle|up-regulation of ubiquitin ligase activity during meiotic cell cycle|activation of anaphase-promoting complex activity during meiotic cell cycle|upregulation of ubiquitin ligase activity during meiotic cell cycle|meiotic APC activation https://github.com/geneontology/go-ontology/issues/15196 This term was obsoleted because it should be captured as a GO-CAM model. True GO:0051487 biological_process owl:Class
GO:0015460 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048043 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038052 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903806 biolink:NamedThing L-isoleucine import across plasma membrane The directed movement of L-isoleucine from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti L-isoleucine import into cell|isoleucine import|L-isoleucine import tb 2012-10-01T11:10:51Z GO:0090477|GO:0090476 biological_process owl:Class
GO:0004872 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001137 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001135 biolink:NamedThing obsolete RNA polymerase II transcription regulator recruiting activity OBSOLETE. The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation. got7fsn_ti transcription factor activity, RNA polymerase II transcription factor recruiting|transcription factor activity, TFIIE-class transcription factor recruiting|RNA polymerase II transcription factor recruiting transcription factor activity|RNA polymerase II transcription factor recruiting activity|transcription factor activity, TFIIF-class transcription factor recruiting|transcription factor activity, TFIIH-class transcription factor recruiting|TFIIF-class transcription factor recruiting transcription factor activity|TFIIE-class transcription factor recruiting transcription factor activity|TFIIH-class transcription factor recruiting transcription factor activity https://github.com/geneontology/go-ontology/issues/18561|https://github.com/geneontology/go-ontology/issues/15795 GO:0003712 The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'. krc 2011-01-20T05:13:12Z True GO:0001136|GO:0001137|GO:0001138 molecular_function owl:Class
GO:0090247 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090248 biolink:NamedThing cell migration involved in somitogenic axis elongation Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation. got7fsn_ti cell motility involved in somitogenic axis elongation https://github.com/geneontology/go-annotation/issues/2040 tb 2010-01-22T11:13:59Z GO:0090247 biological_process owl:Class
GO:0052309 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019967 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000129 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075143 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004811 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000357 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090197 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032722 biolink:NamedThing positive regulation of chemokine production Any process that activates or increases the frequency, rate, or extent of chemokine production. got7fsn_ti up regulation of chemokine production|stimulation of chemokine production|positive regulation of chemokine secretion|upregulation of chemokine production|up-regulation of chemokine production|positive regulation of chemokine biosynthetic process|activation of chemokine production tb 2009-12-18T11:28:00Z GO:0045080|GO:0090197 biological_process owl:Class
GO:0035085 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035532 biolink:NamedThing negative regulation of chemokine (C-C motif) ligand 6 production Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6). got7fsn_ti negative regulation of CCL6 production|negative regulation of chemokine (C-C motif) ligand 6 secretion bf 2010-05-07T10:23:40Z GO:0035536 biological_process owl:Class
GO:0017167 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018318 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102078 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902467 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032673 biolink:NamedThing regulation of interleukin-4 production Any process that modulates the frequency, rate, or extent of interleukin-4 production. got7fsn_ti regulation of IL-4 production|regulation of interleukin-4 secretion|regulation of interleukin-4 biosynthetic process GO:0045402|GO:0150133 biological_process owl:Class
GO:0102908 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015418 biolink:NamedThing ABC-type quaternary ammonium compound transporting activity Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in). got7fsn_ti ATP-dependent quaternary-ammonium compound transmembrane transporting activity|quaternary-ammonium-compound ABC transporter|glycine betaine/proline porter activity|quaternary-ammonium-compound-transporting ATPase activity|quaternary amine uptake transporter activity|quaternary-amine-transporting ATPase activity|ATPase-coupled quaternary ammonium compound transmembrane transporting activity|quarternary amine transporter activity GO:0102908 RHEA:11036|EC:7.6.2.9|MetaCyc:RXN-8638|MetaCyc:3.6.3.32-RXN molecular_function owl:Class
GO:0045215 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008969 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052537 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044705 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048424 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051662 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006872 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052300 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052161 biolink:NamedThing obsolete modulation by symbiont of defense-related host cell wall thickening OBSOLETE. Any process in which an organism modulates the frequency, rate or extent of host processes resulting in the thickening of its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti modulation by organism of defense-related cell wall thickening in other organism involved in symbiotic interaction|modulation by organism of host defensive cell wall thickening This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. True GO:0052300 biological_process owl:Class
GO:0006010 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051156 biolink:NamedThing glucose 6-phosphate metabolic process The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. got7fsn_ti glucose 6-phosphate utilization|glucose 6-phosphate metabolism GO:0006010 biological_process owl:Class
GO:0016967 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015388 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902949 biolink:NamedThing positive regulation of tau-protein kinase activity Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity. got7fsn_ti up regulation of brain protein kinase PK40erk activity|activation of STK31|up regulation of tau-protein kinase II activity|upregulation of tau-protein kinase I activity|positive regulation of TTK|positive regulation of glycogen synthase kinase-3beta activity|up-regulation of tau-protein kinase I activity|activation of tau-protein kinase I activity|positive regulation of tau-protein kinase I activity|up-regulation of TTK|positive regulation of protein tau kinase activity|upregulation of GSK|upregulation of tau-protein kinase II activity|positive regulation of cdk5/p20|up-regulation of TPK I|upregulation of TPK|upregulation of [Tau protein] kinase activity|up regulation of TTK|up-regulation of TPK|positive regulation of STK31|positive regulation of tau-protein kinase II activity|activation of tau kinase activity|up-regulation of STK31|positive regulation of TPK I|positive regulation of tau protein kinase activity|activation of CDK5/p23|activation of protein tau kinase activity|activation of [Tau protein] kinase activity|upregulation of tau-tubulin kinase activity|positive regulation of TPK II|activation of tau-protein kinase activity|up-regulation of glycogen synthase kinase-3beta activity|upregulation of glycogen synthase kinase-3beta activity|activation of cdk5/p20|positive regulation of TPK|up regulation of tau kinase activity|activation of TTK|activation of glycogen synthase kinase-3beta activity|up-regulation of tau-protein kinase II activity|activation of brain protein kinase PK40erk activity|up regulation of protein tau kinase activity|up-regulation of tau-tubulin kinase activity|up regulation of STK31|up-regulation of [Tau protein] kinase activity|up regulation of cdk5/p20|up regulation of tau protein kinase activity|activation of GSK|upregulation of STK31|upregulation of TPK I|upregulation of tau protein kinase activity|upregulation of tau kinase activity|upregulation of CDK5/p23|up-regulation of tau protein kinase activity|up-regulation of GSK|up-regulation of TPK II|up regulation of TPK I|upregulation of protein tau kinase activity|activation of tau-protein kinase II activity|positive regulation of brain protein kinase PK40erk activity|up-regulation of protein tau kinase activity|upregulation of brain protein kinase PK40erk activity|up-regulation of tau-protein kinase activity|activation of TPK II|activation of TPK I|positive regulation of GSK|activation of tau-tubulin kinase activity|activation of tau protein kinase activity|up regulation of tau-protein kinase I activity|positive regulation of [Tau protein] kinase activity|upregulation of tau-protein kinase activity|positive regulation of tau kinase activity|up-regulation of tau kinase activity|upregulation of TPK II|upregulation of cdk5/p20|positive regulation of CDK5/p23|up regulation of CDK5/p23|up regulation of [Tau protein] kinase activity|up regulation of tau-tubulin kinase activity|activation of TPK|up-regulation of cdk5/p20|up-regulation of CDK5/p23|up regulation of TPK|up-regulation of brain protein kinase PK40erk activity|upregulation of TTK|up regulation of tau-protein kinase activity|up regulation of TPK II|up regulation of glycogen synthase kinase-3beta activity|up regulation of GSK|positive regulation of tau-tubulin kinase activity sjp 2014-05-02T08:43:38Z biological_process owl:Class
GO:0030607 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098893 biolink:NamedThing extrinsic component of postsynaptic endocytic zone The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti cellular_component owl:Class
GO:0016276 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018223 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015852 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006863 biolink:NamedThing purine nucleobase transport The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti purine base transport|purine transport|purine base transmembrane transport|purine transmembrane transport GO:0015852 biological_process owl:Class
GO:0018536 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010552 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030764 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099553 biolink:NamedThing trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:1902450 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000065 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098935 biolink:NamedThing dendritic transport The directed movement of organelles or molecules along microtubules in dendrites. got7fsn_ti dendrite cargo transport biological_process owl:Class
GO:0045946 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900475 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072640 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099065 biolink:NamedThing integral component of spine apparatus membrane The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti cellular_component owl:Class
GO:0071790 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005380 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903458 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005032 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042477 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006455 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018373 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019691 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006258 biolink:NamedThing UDP-glucose catabolic process The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. got7fsn_ti UDP-glucose catabolism|UDP-glucose conversion|UDP-glucose degradation|UDP-glucose breakdown GO:0019691 biological_process owl:Class
GO:0039515 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042506 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003744 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032518 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045555 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032719 biolink:NamedThing negative regulation of TRAIL production Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production. got7fsn_ti inhibition of TRAIL production|downregulation of TRAIL production|negative regulation of TRAIL biosynthetic process|down-regulation of TRAIL production|down regulation of TRAIL production GO:0045555 biological_process owl:Class
GO:0006151 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102316 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002743 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002719 biolink:NamedThing negative regulation of cytokine production involved in immune response Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response. got7fsn_ti negative regulation of cytokine production during immune response|down-regulation of cytokine production during immune response|negative regulation of cytokine secretion involved in immune response|downregulation of cytokine production during immune response|inhibition of cytokine production during immune response|negative regulation of cytokine biosynthetic process involved in immune response|down regulation of cytokine production during immune response GO:0002743|GO:0002740 biological_process owl:Class
GO:0045393 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900165 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902303 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016225 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001638 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004093 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990614 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045016 biolink:NamedThing mitochondrial magnesium ion transmembrane transport The process in which a magnesium ion (Mg2+) is transported across a mitochondrial membrane, into or out of the mitochondrion. got7fsn_ti mitochondrial magnesium ion transport mcc 2015-01-21T17:44:38Z GO:1990614 biological_process owl:Class
GO:0001200 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044428 biolink:NamedThing obsolete nuclear part OBSOLETE. Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. got7fsn_ti nucleus component|nuclear subcomponent Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005634 True NIF_Subcellular:sao1499850686 cellular_component owl:Class
GO:0008778 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043285 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016686 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035690 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018090 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904468 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032720 biolink:NamedThing negative regulation of tumor necrosis factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production. got7fsn_ti negative regulation of tumor necrosis factor biosynthetic process|negative regulation TNF-alpha production|inhibition of tumor necrosis factor production|down regulation of tumor necrosis factor production|inhibition of cachectin production|negative regulation tumor necrosis factor-alpha production|negative regulation of tumor necrosis factor secretion|down-regulation of tumor necrosis factor production|negative regulation TNF production|downregulation of tumor necrosis factor production Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). sl 2015-07-09T19:50:08Z GO:0042536|GO:1904468 biological_process owl:Class
GO:0010554 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000071 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005033 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052413 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030146 biolink:NamedThing obsolete diuresis OBSOLETE. The process of renal water excretion. got7fsn_ti positive regulation of renal water excretion|diuresis|renal water excretion This term was made obsolete because its definition was inaccurate. GO:0035810 True GO:0003076 Wikipedia:Diuresis biological_process owl:Class
GO:0005498 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051837 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008003 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046674 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043725 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052045 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043072 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005676 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044452 biolink:NamedThing obsolete nucleolar part OBSOLETE. Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. got7fsn_ti nucleolus component Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005730 True cellular_component owl:Class
GO:0042504 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075601 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060881 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034769 biolink:NamedThing basement membrane disassembly The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion. got7fsn_ti basal lamina disassembly Note that this term has no relationship to 'membrane disassembly ; GO:0030397' because the basement membrane is not a lipid bilayer. dph 2009-08-13T11:27:24Z GO:0060881 biological_process owl:Class
GO:0003287 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903275 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015589 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032317 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048117 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046650 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032728 biolink:NamedThing positive regulation of interferon-beta production Any process that activates or increases the frequency, rate, or extent of interferon-beta production. got7fsn_ti positive regulation of IFN-beta production|upregulation of interferon-beta production|up-regulation of interferon-beta production|stimulation of interferon-beta production|up regulation of interferon-beta production|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta secretion|activation of interferon-beta production GO:0045359|GO:0035549 biological_process owl:Class
GO:0015163 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016547 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097521 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045524 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009928 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042534 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032680 biolink:NamedThing regulation of tumor necrosis factor production Any process that modulates the frequency, rate or extent of tumor necrosis factor production. got7fsn_ti regulation of tumor necrosis factor-alpha production|regulation of tumor necrosis factor biosynthetic process|regulation of TNF production|regulation of TNF-alpha production|regulation of cachectin production|regulation of tumor necrosis factor secretion Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). sl 2015-07-09T19:50:02Z GO:1904467|GO:0042534 biological_process owl:Class
GO:0052397 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042508 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005855 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034047 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990291 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046731 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048068 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042239 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001214 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072443 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008105 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031454 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005329 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001009 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001644 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001075 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901240 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051023 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030102 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005807 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033753 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072601 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035467 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009105 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018728 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043775 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072372 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032754 biolink:NamedThing positive regulation of interleukin-5 production Any process that activates or increases the frequency, rate, or extent of interleukin-5 production. got7fsn_ti positive regulation of interleukin-5 secretion|positive regulation of interleukin-5 biosynthetic process|upregulation of interleukin-5 production|up-regulation of interleukin-5 production|stimulation of interleukin-5 production|activation of interleukin-5 production|positive regulation of IL-5 production|up regulation of interleukin-5 production GO:0045407|GO:2000664 biological_process owl:Class
GO:0099189 biolink:NamedThing postsynaptic spectrin-associated cytoskeleton The portion of the spectrin-associated cytoskeleton contained within the postsynapse. got7fsn_ti dos 2017-12-20T15:29:09Z cellular_component owl:Class
GO:0090198 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032682 biolink:NamedThing negative regulation of chemokine production Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production. got7fsn_ti inhibition of chemokine production|downregulation of chemokine production|down regulation of chemokine production|negative regulation of chemokine secretion|down-regulation of chemokine production|negative regulation of chemokine biosynthetic process 2009-12-18T11:28:00Z GO:0045079|GO:0090198 biological_process owl:Class
GO:0020012 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015873 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032857 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042155 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008348 biolink:NamedThing negative regulation of antimicrobial humoral response Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response. got7fsn_ti inhibition of antimicrobial humoral response|down-regulation of antimicrobial humoral response|down regulation of antimicrobial humoral response|downregulation of antimicrobial humoral response|attenuation of antimicrobial humoral response GO:0042155|GO:0042154 biological_process owl:Class
GO:0090040 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901690 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015579 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015497 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006834 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990163 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043926 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050713 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032691 biolink:NamedThing negative regulation of interleukin-1 beta production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production. got7fsn_ti negative regulation of IL-1 beta production|negative regulation of interleukin-1 beta biosynthetic process|inhibition of interleukin-1 beta production|downregulation of interleukin-1 beta production|down regulation of interleukin-1 beta production|negative regulation of interleukin-1 beta secretion|down-regulation of interleukin-1 beta production GO:0050713|GO:0050724 biological_process owl:Class
GO:0008122 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044746 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050754 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030615 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050875 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990707 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048410 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001224 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015329 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015495 biolink:NamedThing gamma-aminobutyric acid:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in). got7fsn_ti 4-aminobutanoate:proton symporter activity|gamma-aminobutyric acid permease activity|gamma-aminobutyric acid:hydrogen symporter activity|GABA:proton symporter activity|4-aminobutanoate:hydrogen symporter activity|4-aminobutyrate:proton symporter activity|4-aminobutyrate:hydrogen symporter activity|GABA:hydrogen symporter activity See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'. GO:0015329|GO:0005331 Reactome:R-HSA-428625 molecular_function owl:Class
GO:0032191 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900455 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060256 biolink:NamedThing regulation of flocculation Any process that modulates the rate, frequency or extent of the non-sexual aggregation of single-celled organisms. got7fsn_ti regulation of flocculation via cell wall protein-carbohydrate interaction dgf 2012-05-01T05:03:32Z GO:1900455 biological_process owl:Class
GO:0018354 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903261 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016745 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097689 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015122 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006243 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046036 biolink:NamedThing CTP metabolic process The chemical reactions and pathways involving CTP, cytidine triphosphate. got7fsn_ti CTP metabolism|CTP deamination GO:0006243 biological_process owl:Class
GO:2001181 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052276 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005913 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061490 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098708 biolink:NamedThing glucose import across plasma membrane The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti high affinity glucose import|glucose import into cell al 2012-12-06T14:54:07Z GO:1990821|GO:0061490 biological_process owl:Class
GO:0042460 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048404 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044055 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002374 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004710 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070750 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043206 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902578 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051471 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042917 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075125 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008596 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030472 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042312 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033587 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072609 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052254 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045425 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016904 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075059 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904805 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042535 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032760 biolink:NamedThing positive regulation of tumor necrosis factor production Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production. got7fsn_ti positive regulation of TNF-alpha production|positive regulation of TNF production|upregulation of tumor necrosis factor production|positive regulation of TNF secretion|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor formation|positive regulation of tumor necrosis factor secretion|activation of tumor necrosis factor production|up regulation of tumor necrosis factor production|positive regulation of tumor necrosis factor biosynthesis|positive regulation of tumor necrosis factor-alpha production|stimulation of tumor necrosis factor production|up-regulation of tumor necrosis factor production|positive regulation of cachectin secretion Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). sl 2015-07-09T19:50:14Z GO:0042535|GO:1904469 biological_process owl:Class
GO:0097404 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098720 biolink:NamedThing succinate import across plasma membrane The directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti succinate import into cell pr 2012-10-29T11:17:44Z GO:0097404 biological_process owl:Class
GO:0098602 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051313 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004597 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008027 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015501 biolink:NamedThing glutamate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). got7fsn_ti sodium/excitatory glutamate cotransporter activity|sodium/excitatory glutamate symporter activity GO:0008027 RHEA:29031 molecular_function owl:Class
GO:0043360 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003907 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045372 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032658 biolink:NamedThing regulation of interleukin-15 production Any process that modulates the frequency, rate, or extent of interleukin-15 production. got7fsn_ti regulation of IL-15 production|regulation of interleukin-15 biosynthetic process GO:0045372 biological_process owl:Class
GO:0005296 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005578 biolink:NamedThing got7fsn_ti True owl:Class
GO:0080063 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902409 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045378 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032660 biolink:NamedThing regulation of interleukin-17 production Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. got7fsn_ti regulation of CTLA-8 production|regulation of IL-17 production|regulation of interleukin-17 biosynthetic process|regulation of interleukin-17 secretion|regulation of Cytotoxic T-lymphocyte-associated antigen 8 secretion GO:0045378|GO:1905076 biological_process owl:Class
GO:0006442 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008368 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051636 biolink:NamedThing obsolete Gram-negative bacterial cell surface binding OBSOLETE. Binding to a component on the surface of a Gram-negative bacterial cell. got7fsn_ti Gram-negative bacterium binding|binding to Gram-negative bacterium|Gram-negative bacterium cell surface binding|Gram-negative bacterial cell surface binding|Gram-negative bacterial binding This term was made obsolete because it is an unnecessary grouping term and was causing confusion. GO:0050829|GO:0003823 True GO:0008368 molecular_function owl:Class
GO:0008590 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099114 biolink:NamedThing got7fsn_ti True owl:Class
GO:0065006 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002137 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903309 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905268 biolink:NamedThing negative regulation of chromatin organization Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization. got7fsn_ti negative regulation of chromatin organisation|inhibition of chromatin organisation|down-regulation of chromatin organization|inhibition of establishment or maintenance of chromatin architecture|downregulation of chromatin organization|down regulation of chromatin organisation|downregulation of establishment or maintenance of chromatin architecture|negative regulation of establishment or maintenance of chromatin architecture|downregulation of chromatin organisation|inhibition of chromatin organization|down-regulation of chromatin organisation|down regulation of chromatin organization|down regulation of establishment or maintenance of chromatin architecture|down-regulation of establishment or maintenance of chromatin architecture|negative regulation of chromatin modification pr 2016-06-15T20:14:47Z GO:1903309 biological_process owl:Class
GO:0005306 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043753 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008501 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015569 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017066 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008731 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004182 biolink:NamedThing obsolete carboxypeptidase A activity OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. got7fsn_ti tissue carboxypeptidase A|carboxypolypeptidase activity|pancreatic carboxypeptidase A|carboxypeptidase A activity GO:0004181 This term was made obsolete because it represents a gene product. True GO:0008731 molecular_function owl:Class
GO:0042528 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048591 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052561 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044213 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015999 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000980 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016003 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019734 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902665 biolink:NamedThing response to isobutanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isobutanol stimulus. got7fsn_ti response to 2-methylpropan-1-ol|process resulting in tolerance to isobutanol GO:1990337 biological_process owl:Class
GO:0000997 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032856 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034600 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001226 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042257 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015623 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045252 biolink:NamedThing oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). got7fsn_ti dihydrolipoamide S-succinyltransferase complex See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. cellular_component owl:Class
GO:0035413 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090263 biolink:NamedThing positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. got7fsn_ti positive regulation of catenin import into nucleus|positive regulation of Wnt receptor signaling pathway through beta-catenin|positive regulation of catenin protein nuclear translocation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt-activated signaling pathway|positive regulation of canonical Wnt receptor signalling pathway tb 2010-02-03T04:32:16Z GO:0035413 biological_process owl:Class
GO:0042484 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001185 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048175 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032605 biolink:NamedThing hepatocyte growth factor production The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti HGF production|hepatocyte growth factor biosynthetic process|scatter factor production GO:0048175 biological_process owl:Class
GO:0102192 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030358 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075123 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003125 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045392 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006514 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030065 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034459 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000037 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072650 biolink:NamedThing got7fsn_ti True owl:Class
GO:0047752 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010175 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044810 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044783 biolink:NamedThing got7fsn_ti True owl:Class
GO:0012503 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015510 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000125 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043016 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002742 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051576 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016660 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052932 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004330 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140249 biolink:NamedThing protein catabolic process at postsynapse The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. got7fsn_ti https://github.com/geneontology/synapse/issues/204 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T10:25:04Z biological_process owl:Class
GO:0030138 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008279 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016451 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015688 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045539 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015463 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050827 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046749 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007067 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098951 biolink:NamedThing intrinsic component of postsynaptic recycling endosome membrane The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to postsynaptic recycling endosome membrane cellular_component owl:Class
GO:0052423 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018239 biolink:NamedThing got7fsn_ti True owl:Class
GO:0080087 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150169 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048747 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052299 biolink:NamedThing got7fsn_ti True owl:Class
GO:0020034 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046699 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035535 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031189 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042434 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071779 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061745 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008629 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007582 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045390 biolink:NamedThing got7fsn_ti True owl:Class
GO:0055132 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018986 biolink:NamedThing got7fsn_ti True owl:Class
GO:0040001 biolink:NamedThing establishment of mitotic spindle localization The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs. got7fsn_ti mitotic spindle positioning|spindle positioning during mitosis|mitotic spindle positioning or orientation|mitotic spindle positioning and orientation|spindle positioning involved in mitotic cell cycle|establishment of mitotic spindle localisation GO:0030610|GO:0018986|GO:0030606|GO:0030608|GO:0030605 biological_process owl:Class
GO:0044455 biolink:NamedThing obsolete mitochondrial membrane part OBSOLETE. Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0031966 True cellular_component owl:Class
GO:0036231 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019193 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046728 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016968 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052370 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071841 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004770 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048231 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075006 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003996 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902715 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006467 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005336 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016537 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052060 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004220 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010386 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008468 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019839 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090142 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002166 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015508 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044212 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072358 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902431 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098721 biolink:NamedThing uracil import across plasma membrane The directed movement of uracil from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti uracil import into cell tb 2013-09-27T17:54:23Z GO:1902431 biological_process owl:Class
GO:0032894 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035431 biolink:NamedThing negative regulation of gluconate transmembrane transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. got7fsn_ti down-regulation of gluconate transport|down regulation of gluconate transport|inhibition of gluconate transport|negative regulation of gluconate membrane transport|downregulation of gluconate transport|negative regulation of gluconate transport bf 2010-04-08T10:39:08Z GO:0032894 biological_process owl:Class
GO:0016568 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044710 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052405 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009592 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005090 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016178 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902067 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098741 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030898 biolink:NamedThing got7fsn_ti True owl:Class
GOP:systematic_synonym biolink:NamedThing Systematic synonym got7fsn_ti owl:AnnotationProperty
OIO:SynonymTypeProperty biolink:NamedThing synonym_type_property got7fsn_ti owl:AnnotationProperty
GO:0072632 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045366 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032656 biolink:NamedThing regulation of interleukin-13 production Any process that modulates the frequency, rate, or extent of interleukin-13 production. got7fsn_ti regulation of interleukin-13 biosynthetic process|regulation of IL-13 production|regulation of interleukin-13 secretion GO:0045366|GO:2000665 biological_process owl:Class
GO:0016954 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901237 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048419 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001071 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033589 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017079 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004002 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042087 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072446 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016193 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032503 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048176 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032646 biolink:NamedThing regulation of hepatocyte growth factor production Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production. got7fsn_ti regulation of hepatocyte growth factor biosynthetic process|regulation of HGF production|regulation of scatter factor production GO:0048176 biological_process owl:Class
GO:0000040 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150131 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015490 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043872 biolink:NamedThing lysine:cadaverine antiporter activity Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out). got7fsn_ti lysine/cadaverine antiporter activity|cadaverine:lysine antiporter activity|lysine-cadaverine antiporter activity|cadaverine transmembrane transporter activity GO:0015497|GO:0015490 molecular_function owl:Class
GO:0035057 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004406 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044431 biolink:NamedThing obsolete Golgi apparatus part OBSOLETE. Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. got7fsn_ti Golgi component|Golgi subcomponent Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005794 True NIF_Subcellular:sao624292949 cellular_component owl:Class
GO:0005959 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003766 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150154 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005348 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006342 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043690 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015978 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045441 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072654 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001668 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045367 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001585 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060248 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015404 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032522 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033669 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052151 biolink:NamedThing positive regulation by symbiont of host apoptotic process Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death in the host, where programmed cell death proceeds by apoptosis. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti induction by organism of host apoptotic programmed cell death|activation by symbiont of host apoptosis|up-regulation by organism of host apoptotic programmed cell death|upregulation by symbiont of host apoptosis|activation by organism of host apoptosis|stimulation by symbiont of host apoptosis|upregulation by organism of host apoptotic programmed cell death|positive regulation by symbiont of host apoptosis|up regulation by organism of host apoptotic programmed cell death|up regulation by symbiont of host apoptosis|up-regulation by symbiont of host apoptosis|positive regulation by organism of host apoptotic programmed cell death|activation by organism of host apoptotic programmed cell death|induction by symbiont of host apoptosis Note that term is to be used to annotate gene products in the symbiont. To annotate host gene products, consider the biological process term 'positive regulation of apoptosis ; GO:0043065'. GO:0052030|GO:0033669 biological_process owl:Class
GO:0018319 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004943 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046407 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052459 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015588 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000790 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045166 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052061 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015580 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016190 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043348 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019014 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099007 biolink:NamedThing extrinsic component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti cellular_component owl:Class
GO:1901259 biolink:NamedThing chloroplast rRNA processing Any rRNA processing that takes place in chloroplast. got7fsn_ti tb 2012-08-10T17:43:19Z biological_process owl:Class
GO:0070812 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004094 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052253 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052510 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904440 biolink:NamedThing positive regulation of iron ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane. got7fsn_ti activation of ferrous ion import into cell|upregulation of ferrous iron import across plasma membrane|upregulation of ferrous ion import into cell|up-regulation of ferrous ion import into cell|up regulation of ferrous ion import into cell|activation of ferrous iron import across plasma membrane|up-regulation of ferrous iron import across plasma membrane|up regulation of ferrous iron import across plasma membrane|positive regulation of ferrous iron import across plasma membrane|positive regulation of ferrous iron import into cell|positive regulation of ferrous ion import into cell rl 2015-07-06T13:50:04Z GO:1903991 biological_process owl:Class
GO:0043439 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016081 biolink:NamedThing synaptic vesicle docking The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process. got7fsn_ti synaptic vesicle docking during exocytosis|synaptic vesicle docking involved in exocytosis Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015). biological_process owl:Class
GO:0048110 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015285 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032893 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051530 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902700 biolink:NamedThing pentose catabolic process to butan-1-ol The chemical reactions and pathways resulting in the breakdown of pentose to butan-1-ol. got7fsn_ti pentose catabolism to butan-1-ol|solventogenesis|pentose catabolic process to 1-butanol|pentose degradation to butan-1-ol|pentose catabolic process to butanol|pentose breakdown to butan-1-ol tb 2014-02-19T18:28:47Z GO:1990290 biological_process owl:Class
GO:0050880 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006691 biolink:NamedThing leukotriene metabolic process The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. got7fsn_ti leukotriene metabolism biological_process owl:Class
GO:0005644 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031980 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008555 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015725 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045288 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048416 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990307 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098636 biolink:NamedThing protein complex involved in cell adhesion Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. got7fsn_ti cell adhesion complex GO:1990307 cellular_component owl:Class
GO:0030462 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009817 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004606 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008060 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019581 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019392 biolink:NamedThing glucarate metabolic process The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate. got7fsn_ti glucarate metabolism GO:0019581 biological_process owl:Class
GO:0080174 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036142 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016228 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052297 biolink:NamedThing got7fsn_ti True owl:Class
GO:0023034 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044446 biolink:NamedThing obsolete intracellular organelle part OBSOLETE. A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0043229 True cellular_component owl:Class
GO:0001199 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072606 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007452 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050489 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035547 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032648 biolink:NamedThing regulation of interferon-beta production Any process that modulates the frequency, rate, or extent of interferon-beta production. got7fsn_ti regulation of interferon-beta secretion|regulation of IFN-beta production|regulation of interferon-beta biosynthetic process GO:0045357|GO:0035547 biological_process owl:Class
GO:0000780 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030453 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000358 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034566 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150149 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001613 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070838 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008644 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045414 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032677 biolink:NamedThing regulation of interleukin-8 production Any process that modulates the frequency, rate, or extent of interleukin-8 production. got7fsn_ti regulation of interleukin-8 secretion|regulation of IL-8 production|regulation of interleukin-8 biosynthetic process GO:0045414|GO:2000482 biological_process owl:Class
GO:0048005 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098918 biolink:NamedThing structural constituent of synapse The action of a molecule that contributes to the structural integrity of a synapse. got7fsn_ti molecular_function owl:Class
GO:0001130 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002818 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071147 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030630 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044235 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070615 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000081 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052268 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043437 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019605 biolink:NamedThing butyrate metabolic process The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid. got7fsn_ti butyric acid metabolic process|butyric acid metabolism|butanoic acid metabolic process|butyrate metabolism|butanoic acid metabolism GO:0043437 biological_process owl:Class
GO:0051375 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007372 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030529 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903757 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034401 biolink:NamedThing obsolete chromatin organization involved in regulation of transcription OBSOLETE. Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription. got7fsn_ti regulation of transcription from RNA polymerase II promoter by histone modification|up-regulation of transcription from RNA polymerase II promoter by histone modification|regulation of transcription from RNA polymerase II promoter, global by histone modification|positive regulation of transcription from Pol II promoter by histone modification|up regulation of transcription from RNA polymerase II promoter by histone modification|regulation of global transcription from Pol II promoter by histone modification|activation of transcription from RNA polymerase II promoter by histone modification|positive regulation of global transcription from Pol II promoter by histone modification|upregulation of global transcription from RNA polymerase II promoter by histone modification|positive regulation of transcription from RNA polymerase II promoter, global by histone modification|regulation of transcription by chromatin organisation|stimulation of global transcription from RNA polymerase II promoter by histone modification|regulation of transcription from Pol II promoter by histone modification|stimulation of transcription from RNA polymerase II promoter by histone modification|up regulation of global transcription from RNA polymerase II promoter by histone modification|positive regulation of transcription from RNA polymerase II promoter by histone modification|upregulation of transcription from RNA polymerase II promoter by histone modification|positive regulation of gene-specific transcription from RNA polymerase II promoter by histone modification|regulation of transcription by chromatin organization|regulation of gene-specific transcription from RNA polymerase II promoter by histone modification|activation of global transcription from RNA polymerase II promoter by histone modification|establishment or maintenance of chromatin architecture during transcription|up-regulation of global transcription from RNA polymerase II promoter by histone modification https://github.com/geneontology/go-ontology/issues/22041 This term was obsoleted because these it was redundant with other terms: heterochromatin assembly and regulation of gene expression, epigenetic. rl 2014-12-18T14:56:16Z True GO:1903756|GO:1903757 biological_process owl:Class
GO:0050381 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990510 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072625 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052291 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000728 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008026 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072453 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010805 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905008 biolink:NamedThing regulation of L-lysine import across plasma membrane Any process that modulates the frequency, rate or extent of L-lysine import into cell. got7fsn_ti regulation of lysine import|regulation of lysine uptake|regulation of L-lysine import into cell sl 2016-03-02T00:15:49Z GO:0010805 biological_process owl:Class
GO:0052273 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016140 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070924 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052258 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031202 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005932 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902534 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008434 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006322 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097349 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102005 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046515 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904208 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000342 biolink:NamedThing negative regulation of chemokine (C-X-C motif) ligand 2 production Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production. got7fsn_ti negative regulation of MIP-2 production|negative regulation of chemokine (C-C motif) ligand 2 secretion|inhibition of chemokine (C-C motif) ligand 2 secretion|negative regulation of SCYB2 production|inhibition of CCL2 secretion|negative regulation of MIP2 production|negative regulation of CXCL2 production mah 2011-02-01T11:57:17Z GO:1904208 biological_process owl:Class
GO:0061747 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006365 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044404 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008562 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030525 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036282 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008799 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045424 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032685 biolink:NamedThing negative regulation of granulocyte macrophage colony-stimulating factor production Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. got7fsn_ti negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|inhibition of granulocyte macrophage colony-stimulating factor production|down-regulation of granulocyte macrophage colony-stimulating factor production|negative regulation of granulocyte macrophage colony stimulating factor production|negative regulation of GM-CSF production|downregulation of granulocyte macrophage colony-stimulating factor production|down regulation of granulocyte macrophage colony-stimulating factor production GO:0045424 biological_process owl:Class
GO:0050721 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032650 biolink:NamedThing regulation of interleukin-1 alpha production Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production. got7fsn_ti regulation of interleukin-1 alpha biosynthetic process|regulation of interleukin-1 alpha secretion|regulation of IL-1 alpha production GO:0050705|GO:0050721 biological_process owl:Class
GO:1900871 biolink:NamedThing chloroplast mRNA modification The covalent alteration within the chloroplast of one or more nucleotides within an mRNA to produce an mRNA molecule with a sequence that differs from that coded genetically. got7fsn_ti chloroplast mRNA editing|mRNA editing in chloroplast dhl 2012-06-12T06:13:58Z biological_process owl:Class
GO:0072643 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006763 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097406 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009814 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150124 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034960 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006870 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008272 biolink:NamedThing sulfate transport The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti sulphate transport GO:0006870 biological_process owl:Class
GO:0060246 biolink:NamedThing got7fsn_ti True owl:Class
OBO:go/go-base.owl biolink:NamedThing Gene Ontology The Gene Ontology (GO) provides a framework and set of concepts for describing the functions of gene products from all organisms. got7fsn_ti gene_ontology 1.2 http://creativecommons.org/licenses/by/4.0/ owl:Ontology 2021-09-01
OBO:go/releases/2021-09-01/go-base.owl biolink:NamedThing got7fsn_ti
GO:2000778 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052632 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046732 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016337 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070890 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043566 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000498 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019190 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052307 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048155 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032715 biolink:NamedThing negative regulation of interleukin-6 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production. got7fsn_ti downregulation of interleukin-6 production|down regulation of interleukin-6 production|inhibition of interleukin-6 production|negative regulation of interleukin-6 biosynthetic process|negative regulation of IL-6 production|negative regulation of interleukin-6 secretion|down-regulation of interleukin-6 production GO:0045409|GO:1900165 biological_process owl:Class
GO:0048411 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005379 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990975 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050755 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042516 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045537 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006136 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048218 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008505 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032320 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001204 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045279 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031575 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036328 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016526 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042061 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004101 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099097 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008739 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018225 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070604 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032704 biolink:NamedThing negative regulation of interleukin-20 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production. got7fsn_ti downregulation of interleukin-20 production|negative regulation of interleukin-20 biosynthetic process|negative regulation of IL-20 production|inhibition of interleukin-20 production|down regulation of interleukin-20 production|down-regulation of interleukin-20 production GO:0045388 biological_process owl:Class
GO:0099067 biolink:NamedThing integral component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti cellular_component owl:Class
GO:0000924 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042319 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000251 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042261 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052445 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015065 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045030 biolink:NamedThing G protein-coupled UTP receptor activity Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP. got7fsn_ti purinoceptor type U|UTP-activated nucleotide receptor activity|uridine nucleotide receptor activity GO:0015065 molecular_function owl:Class
GO:0045525 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007324 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044261 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032735 biolink:NamedThing positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production. got7fsn_ti stimulation of interleukin-12 production|activation of interleukin-12 production|positive regulation of CLMF production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 secretion|positive regulation of IL-12 production|up-regulation of interleukin-12 production|positive regulation of NKSF production|up regulation of interleukin-12 production|upregulation of interleukin-12 production GO:2001184|GO:0045084 biological_process owl:Class
GO:0004785 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070015 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990903 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061495 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019818 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905122 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:5782 biolink:NamedThing got7fsn_ti owl:Class
GO:0048230 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016991 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000168 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045287 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900476 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048751 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000944 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034448 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043356 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005285 biolink:NamedThing got7fsn_ti True owl:Class
OIO:hasExactSynonym biolink:NamedThing has_exact_synonym got7fsn_ti owl:AnnotationProperty
GO:0044125 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045074 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044438 biolink:NamedThing obsolete microbody part OBSOLETE. Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2). got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0042579 True cellular_component owl:Class
GO:1902293 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043044 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006818 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052179 biolink:NamedThing obsolete metabolism by symbiont of host cell wall pectin OBSOLETE. The chemical reactions and pathways performed by an organism involving pectin in the cell wall of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti metabolism by organism of cell wall pectin in other organism involved in symbiotic interaction This term was obsoleted because it represents a molecular function. True GO:0052413 biological_process owl:Class
GO:0030012 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098839 biolink:NamedThing postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. got7fsn_ti cellular_component owl:Class
GO:0008185 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016770 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005386 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099163 biolink:NamedThing synaptic signaling by nitric oxide Cell-cell signaling to or from a synapse, mediated by nitric oxide. got7fsn_ti biological_process owl:Class
GO:0004537 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042830 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019943 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070491 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048431 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000666 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090302 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031662 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010971 biolink:NamedThing positive regulation of G2/M transition of mitotic cell cycle Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. got7fsn_ti positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle|positive regulation of mitotic entry tb 2009-06-01T10:16:34Z GO:0031662 biological_process owl:Class
GO:0019138 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050726 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032730 biolink:NamedThing positive regulation of interleukin-1 alpha production Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production. got7fsn_ti stimulation of interleukin-1 alpha production|up regulation of interleukin-1 alpha production|upregulation of interleukin-1 alpha production|activation of interleukin-1 alpha production|positive regulation of interleukin-1 alpha secretion|positive regulation of IL-1 alpha production|up-regulation of interleukin-1 alpha production|positive regulation of interleukin-1 alpha biosynthetic process GO:0050726|GO:0050717 biological_process owl:Class
GO:0070756 biolink:NamedThing positive regulation of interleukin-35 production Any process that activates or increases the frequency, rate, or extent of interleukin-35 production. got7fsn_ti stimulation of interleukin-35 production|positive regulation of interleukin-35 biosynthetic process|activation of interleukin-35 production|positive regulation of IL-35 production|up regulation of interleukin-35 production|upregulation of interleukin-35 production|up-regulation of interleukin-35 production mah 2009-06-23T01:39:45Z GO:0070752 biological_process owl:Class
GO:0045397 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000365 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046426 biolink:NamedThing negative regulation of receptor signaling pathway via JAK-STAT Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT. got7fsn_ti negative regulation of STAT protein import into nucleus|downregulation of JAK-STAT cascade|down-regulation of JAK-STAT cascade|inhibition of JAK-STAT cascade|down regulation of JAK-STAT cascade|negative regulation of STAT protein nuclear translocation GO:2000365 biological_process owl:Class
GO:0072483 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017035 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003126 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019282 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010000 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072626 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060356 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072607 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032751 biolink:NamedThing positive regulation of interleukin-27 production Any process that activates or increases the frequency, rate, or extent of interleukin-27 production. got7fsn_ti up regulation of interleukin-27 production|positive regulation of IL-27 production|activation of interleukin-27 production|upregulation of interleukin-27 production|up-regulation of interleukin-27 production|positive regulation of interleukin-27 anabolism|stimulation of interleukin-27 production|positive regulation of interleukin-27 biosynthetic process GO:0045539 biological_process owl:Class
GO:0102008 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019192 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005904 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019067 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015639 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018440 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150160 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015598 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031195 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030434 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033155 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052261 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061019 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016073 biolink:NamedThing snRNA metabolic process The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein. got7fsn_ti snRNA metabolism biological_process owl:Class
GO:1902420 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001044 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017127 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030469 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052252 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905056 biolink:NamedThing P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration A calcium-transporting P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration. got7fsn_ti Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration|ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration|Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels|calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration|Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration|calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration|calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration dos 2016-03-17T14:35:25Z molecular_function owl:Class
GO:0035537 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097461 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008099 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048177 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032726 biolink:NamedThing positive regulation of hepatocyte growth factor production Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production. got7fsn_ti positive regulation of HGF production|stimulation of hepatocyte growth factor production|positive regulation of scatter factor production|up regulation of hepatocyte growth factor production|upregulation of hepatocyte growth factor production|up-regulation of hepatocyte growth factor production|activation of hepatocyte growth factor production|positive regulation of hepatocyte growth factor biosynthetic process GO:0048177 biological_process owl:Class
GO:0008589 biolink:NamedThing regulation of smoothened signaling pathway Any process that modulates the frequency, rate or extent of smoothened signaling. got7fsn_ti regulation of hedgehog signaling pathway|regulation of smoothened by patched|regulation of smoothened signalling pathway|regulation of smoothened receptor activity by patched|regulation of hh signaling pathway|regulation of smoothened activity GO:0007226|GO:0043109 biological_process owl:Class
GO:0075129 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072472 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004431 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016654 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034330 biolink:NamedThing cell junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix. got7fsn_ti cell junction biogenesis|cell junction assembly and maintenance|cell junction organisation biological_process owl:Class
GO:0034500 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017037 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043284 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001948 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000598 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903362 biolink:NamedThing regulation of cellular protein catabolic process Any process that modulates the frequency, rate or extent of cellular protein catabolic process. got7fsn_ti regulation of cellular protein degradation|regulation of cellular protein breakdown|regulation of cyclin catabolic process|regulation of degradation of cyclin|regulation of cyclin catabolism|regulation of cellular protein catabolism|regulation of cyclin degradation|regulation of cyclin breakdown kmv 2014-08-21T15:05:45Z GO:2000598 biological_process owl:Class
GO:0009598 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032649 biolink:NamedThing regulation of interferon-gamma production Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. got7fsn_ti regulation of interferon-gamma secretion|regulation of interferon-gamma biosynthetic process|regulation of type II interferon production GO:0045072|GO:1902713 biological_process owl:Class
GO:0044767 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006374 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071149 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051868 biolink:NamedThing got7fsn_ti True owl:Class
GO:0047076 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019642 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017047 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102353 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033742 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044745 biolink:NamedThing got7fsn_ti True owl:Class
GO:0089718 biolink:NamedThing amino acid import across plasma membrane The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti L-amino acid import|amino acid import into cell|amino acid transmembrane import|L-amino acid uptake jl 2012-11-14T14:21:41Z GO:0043092|GO:0044745|GO:1902837 biological_process owl:Class
GO:0071822 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033057 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043391 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006381 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000482 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001203 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001037 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048182 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015559 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016177 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030243 biolink:NamedThing cellulose metabolic process The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. got7fsn_ti cellulose metabolism GO:0016177 biological_process owl:Class
GO:1902217 biolink:NamedThing erythrocyte apoptotic process Any apoptotic process in an erythrocyte. got7fsn_ti RBC apoptotic process|red blood cell apoptosis|erythrocyte apoptosis|red blood cell apoptotic process|RBC apoptosis rl 2013-06-13T10:02:29Z biological_process owl:Class
GO:0050327 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004003 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042787 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002535 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075717 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038051 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042230 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150120 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048605 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042877 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060181 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009795 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099133 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008178 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052527 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002928 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005671 biolink:NamedThing obsolete Ada2/Gcn5/Ada3 transcription activator complex OBSOLETE. A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues. got7fsn_ti ATAC complex https://github.com/geneontology/go-ontology/issues/21335 This term was obsoleted because it was incorrectly annotated. Consider ADA complex ; GO:0140671 or ATAC complex; GO:0140672. GO:0140671|GO:0140672 True GO:0002928 cellular_component owl:Class
GO:0005087 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042510 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030024 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902400 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006961 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045349 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006758 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042234 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016522 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032569 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030499 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150157 biolink:NamedThing regulation of interleukin-34 production Any process that modulates the frequency, rate or extent of interleukin-34 production. got7fsn_ti interleukin-34 biosynthetic process|regulation of interleukin-34 biosynthetic process bc 2020-01-06T16:30:44Z GO:0150160|GO:0150156 biological_process owl:Class
GO:0048421 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035031 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048423 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048553 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902881 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043742 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001035 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044449 biolink:NamedThing obsolete contractile fiber part OBSOLETE. Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. got7fsn_ti contractile fibre component|muscle fiber component|muscle fibre component Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0043292 True cellular_component owl:Class
GO:0000392 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042094 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046652 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005226 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008559 biolink:NamedThing ABC-type xenobiotic transporter activity Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). got7fsn_ti PDR protein|multidrug-resistance protein|multidrug resistance exporter|ATP-dependent xenobiotic transmembrane transporter activity|MDR protein|xenobiotic ABC transporter|ATPase-coupled xenobiotic transmembrane transporter activity|pleiotropic-drug-resistance protein|ATP phosphohydrolase (xenobiotic-exporting)|xenobiotic transmembrane transporting ATPase activity|P-glycoprotein GO:0005226|GO:0008560 EC:7.6.2.2|MetaCyc:3.6.3.44-RXN molecular_function owl:Class
GO:0003869 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044266 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018918 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051855 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052663 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004006 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003936 biolink:NamedThing obsolete hydrogen-transporting two-sector ATPase activity OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). got7fsn_ti hydrogen-transporting two-sector ATPase activity|proton-transporting two-sector ATPase activity This term was made obsolete because it refers to a bifunctional gene product. GO:0046933|GO:0046961 True GO:0004006|GO:0008729 molecular_function owl:Class
GO:0019925 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042527 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034621 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902522 biolink:NamedThing response to 4'-epidoxorubicin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4'-epidoxorubicin stimulus. got7fsn_ti response to epirubicin Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. dw 2013-12-02T09:44:31Z biological_process owl:Class
GO:0032513 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001131 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045286 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001180 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060150 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099147 biolink:NamedThing extrinsic component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti dos 2017-07-05T10:44:43Z cellular_component owl:Class
GO:0072413 biolink:NamedThing got7fsn_ti True owl:Class
GO:0055027 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090099 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001133 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052280 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051768 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007045 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042225 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003753 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016538 biolink:NamedThing cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. got7fsn_ti G1/S-specific cyclin|cyclin-dependent protein kinase, intrinsic regulator activity|cyclin|G2/M-specific cyclin|cyclin-dependent protein kinase regulator activity GO:0003752|GO:0003753|GO:0003751 Reactome:R-HSA-3215385|EC:2.7.1.- molecular_function owl:Class
GO:0005860 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051534 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070885 biolink:NamedThing negative regulation of calcineurin-NFAT signaling cascade Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. got7fsn_ti down regulation of calcineurin-NFAT signaling cascade|inhibition of calcineurin-NFAT signaling cascade|inhibition of NFAT protein import into nucleus|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of NFAT protein import into nucleus|downregulation of calcineurin-NFAT signaling cascade|negative regulation of calcineurin-NFAT signalling cascade|termination of calcineurin-NFAT signaling cascade|down-regulation of calcineurin-NFAT signaling cascade mah 2009-08-26T03:29:33Z GO:0051534 biological_process owl:Class
GO:0045379 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033279 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050443 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045368 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032736 biolink:NamedThing positive regulation of interleukin-13 production Any process that activates or increases the frequency, rate, or extent of interleukin-13 production. got7fsn_ti upregulation of interleukin-13 production|positive regulation of interleukin-13 biosynthetic process|up-regulation of interleukin-13 production|positive regulation of interleukin-13 secretion|activation of interleukin-13 production|up regulation of interleukin-13 production|stimulation of interleukin-13 production|positive regulation of IL-13 production GO:2000667|GO:0045368 biological_process owl:Class
GO:1990054 biolink:NamedThing response to temozolomide Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temozolomide stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. pr 2013-02-22T10:09:44Z biological_process owl:Class
GO:0016349 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008560 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018371 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071148 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019224 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008895 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043925 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015082 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018369 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903262 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004685 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004891 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051243 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903887 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045085 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032703 biolink:NamedThing negative regulation of interleukin-2 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production. got7fsn_ti down-regulation of interleukin-2 production|negative regulation of IL-2 production|inhibition of interleukin-2 production|down regulation of interleukin-2 production|negative regulation of interleukin-2 secretion|negative regulation of interleukin-2 biosynthetic process|downregulation of interleukin-2 production GO:1900041|GO:0045085 biological_process owl:Class
GO:0050718 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043033 biolink:NamedThing isoamylase complex A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. got7fsn_ti debranching enzyme complex cellular_component owl:Class
GO:2000663 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032714 biolink:NamedThing negative regulation of interleukin-5 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production. got7fsn_ti down regulation of interleukin-5 production|negative regulation of IL-5 production|downregulation of interleukin-5 production|inhibition of interleukin-5 production|negative regulation of interleukin-5 secretion|down-regulation of interleukin-5 production|negative regulation of interleukin-5 biosynthetic process GO:2000663|GO:0045406 biological_process owl:Class
GO:1902739 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032647 biolink:NamedThing regulation of interferon-alpha production Any process that modulates the frequency, rate, or extent of interferon-alpha production. got7fsn_ti regulation of interferon-alpha secretion|regulation of interferon-alpha biosynthetic process GO:0045354|GO:1902739 biological_process owl:Class
GO:0005403 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046801 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009096 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015542 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016168 biolink:NamedThing chlorophyll binding Binding to a chlorophyll; a compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. got7fsn_ti molecular_function owl:Class
GO:0000925 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902968 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019739 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007609 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009591 biolink:NamedThing obsolete perception of mechanical stimulus OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal. got7fsn_ti perception of mechanical stimulus This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. GO:0050954 True GO:0007609 biological_process owl:Class
GO:0052456 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000662 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032674 biolink:NamedThing regulation of interleukin-5 production Any process that modulates the frequency, rate, or extent of interleukin-5 production. got7fsn_ti regulation of interleukin-5 secretion|regulation of IL-5 production|regulation of interleukin-5 biosynthetic process GO:0045405|GO:2000662 biological_process owl:Class
GO:0005312 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903363 biolink:NamedThing negative regulation of cellular protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process. got7fsn_ti inhibition of cellular protein catabolic process|downregulation of cellular protein degradation|downregulation of cellular protein catabolism|down-regulation of cellular protein breakdown|negative regulation of cellular protein degradation|negative regulation of cellular protein breakdown|negative regulation of cyclin catabolism|down regulation of cellular protein catabolic process|inhibition of cellular protein degradation|down-regulation of cellular protein degradation|negative regulation of degradation of cyclin|negative regulation of cyclin degradation|negative regulation of cyclin catabolic process|inhibition of cellular protein catabolism|down-regulation of cellular protein catabolic process|down regulation of cellular protein degradation|down-regulation of cellular protein catabolism|downregulation of cellular protein catabolic process|downregulation of cellular protein breakdown|negative regulation of cyclin breakdown|inhibition of cellular protein breakdown|down regulation of cellular protein catabolism|negative regulation of cellular protein catabolism|down regulation of cellular protein breakdown kmv 2014-08-21T15:05:53Z GO:2000599 biological_process owl:Class
GO:0042485 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042482 biolink:NamedThing positive regulation of odontogenesis Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth. got7fsn_ti positive regulation of tooth development|up regulation of odontogenesis|positive regulation of odontogenesis of calcareous or chitinous tooth|upregulation of odontogenesis|stimulation of odontogenesis|up-regulation of odontogenesis|activation of odontogenesis GO:0042485 biological_process owl:Class
GO:0048120 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001180 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036079 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045538 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030179 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045404 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102437 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022844 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006938 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072661 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015396 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042108 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042229 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099182 biolink:NamedThing presynaptic intermediate filament cytoskeleton The intermediate filament cytoskeleton that is part of a presynapse. got7fsn_ti dos 2017-12-01T18:10:21Z cellular_component owl:Class
GO:0075122 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045153 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045076 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032663 biolink:NamedThing regulation of interleukin-2 production Any process that modulates the frequency, rate, or extent of interleukin-2 production. got7fsn_ti regulation of IL-2 production|regulation of interleukin-2 biosynthetic process|regulation of interleukin-2 secretion GO:0045076|GO:1900040 biological_process owl:Class
GO:0047984 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034636 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902095 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017034 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903276 biolink:NamedThing regulation of sodium ion export across plasma membrane Any process that modulates the frequency, rate or extent of sodium ion export across the plasma membrane. got7fsn_ti regulation of sodium export|regulation of sodium ion export|regulation of sodium ion export from cell rl 2014-08-08T17:06:46Z GO:1903273 biological_process owl:Class
GO:0042050 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051505 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007459 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001719 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032582 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001041 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030498 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009054 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045086 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019063 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042512 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072395 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044445 biolink:NamedThing obsolete cytosolic part OBSOLETE. Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. got7fsn_ti cytosol component Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005829 True cellular_component owl:Class
GO:0019053 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015249 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097460 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016974 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032749 biolink:NamedThing positive regulation of interleukin-25 production Any process that activates or increases the frequency, rate, or extent of interleukin-25 production. got7fsn_ti upregulation of interleukin-25 production|stimulation of interleukin-25 production|up regulation of interleukin-25 production|activation of interleukin-25 production|positive regulation of interleukin-25 biosynthetic process|up-regulation of interleukin-25 production|positive regulation of interleukin-25 secretion|positive regulation of IL-25 production bc 2019-12-09T16:51:44Z GO:0045537|GO:0150150 biological_process owl:Class
GO:0046675 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042233 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090450 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071436 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006980 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990141 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002226 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045375 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001143 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902828 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052501 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007024 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009681 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048154 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043345 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042089 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045554 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015178 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016245 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090509 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098716 biolink:NamedThing nickel cation import across plasma membrane The directed movement of nickel cations from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti nickel cation import into cell tb 2012-11-16T16:12:53Z GO:0090509 biological_process owl:Class
GO:0045449 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045256 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044116 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035412 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004759 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006358 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072424 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019641 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009680 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043339 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001622 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075716 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006445 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042112 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008602 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042526 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042531 biolink:NamedThing positive regulation of tyrosine phosphorylation of STAT protein Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein. got7fsn_ti stimulation of tyrosine phosphorylation of Stat7 protein|up-regulation of tyrosine phosphorylation of Stat7 protein|upregulation of tyrosine phosphorylation of Stat1 protein|activation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat2 protein|upregulation of tyrosine phosphorylation of Stat2 protein|up-regulation of tyrosine phosphorylation of Stat3 protein|activation of tyrosine phosphorylation of Stat2 protein|up regulation of tyrosine phosphorylation of Stat6 protein|activation of tyrosine phosphorylation of Stat3 protein|stimulation of tyrosine phosphorylation of Stat5 protein|up regulation of tyrosine phosphorylation of Stat7 protein|up-regulation of tyrosine phosphorylation of Stat1 protein|up regulation of tyrosine phosphorylation of STAT protein|up regulation of tyrosine phosphorylation of Stat1 protein|activation of tyrosine phosphorylation of STAT protein|activation of tyrosine phosphorylation of Stat6 protein|stimulation of tyrosine phosphorylation of Stat6 protein|up-regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|up-regulation of tyrosine phosphorylation of STAT protein|activation of tyrosine phosphorylation of Stat7 protein|activation of tyrosine phosphorylation of Stat4 protein|upregulation of tyrosine phosphorylation of Stat5 protein|stimulation of tyrosine phosphorylation of Stat1 protein|stimulation of tyrosine phosphorylation of Stat2 protein|up-regulation of tyrosine phosphorylation of Stat6 protein|up regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat6 protein|up regulation of tyrosine phosphorylation of Stat4 protein|stimulation of tyrosine phosphorylation of Stat3 protein|upregulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|upregulation of tyrosine phosphorylation of STAT protein|up-regulation of tyrosine phosphorylation of Stat2 protein|up regulation of tyrosine phosphorylation of Stat5 protein|activation of tyrosine phosphorylation of Stat5 protein|positive regulation of tyrosine phosphorylation of Stat1 protein|up regulation of tyrosine phosphorylation of Stat2 protein|upregulation of tyrosine phosphorylation of Stat7 protein|positive regulation of tyrosine phosphorylation of Stat7 protein|up-regulation of tyrosine phosphorylation of Stat5 protein|upregulation of tyrosine phosphorylation of Stat4 protein|stimulation of tyrosine phosphorylation of STAT protein|stimulation of tyrosine phosphorylation of Stat4 protein|upregulation of tyrosine phosphorylation of Stat6 protein GO:0042517|GO:0042515|GO:0042529|GO:0042511|GO:0042520|GO:0042526|GO:0042523 biological_process owl:Class
GO:0089712 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006873 biolink:NamedThing cellular ion homeostasis Any process involved in the maintenance of an internal steady state of ions at the level of a cell. got7fsn_ti biological_process owl:Class
GO:0005390 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008900 biolink:NamedThing P-type potassium:proton transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in). got7fsn_ti H(+)/K(+)-ATPase activity|H(+)/K(+)-exchanging ATPase activity|(K+ + H+)-ATPase activity|H+/K+-exchanging ATPase activity|gastric H+/K+ ATPase|ATP phosphohydrolase (H+/K+-exchanging)|hydrogen:potassium-exchanging ATPase activity|H+/K+-ATPase activity|potassium:proton exchanging ATPase activity|gastric H(+)/K(+) ATPase activity|proton pump activity|H+-K+-ATPase activity|H,K-ATPase activity|hydrogen/potassium-exchanging ATPase activity|hydrogen:potassium exchanging ATPase activity https://github.com/geneontology/go-ontology/issues/20821 GO:0005390 EC:7.2.2.19|Reactome:R-HSA-937311|RHEA:22044 molecular_function owl:Class
GO:0045354 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044236 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015088 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007461 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000999 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052044 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038042 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022816 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061748 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016439 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042515 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005485 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035086 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010163 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006811 biolink:NamedThing ion transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0072480 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048418 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097458 biolink:NamedThing obsolete neuron part OBSOLETE. Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. got7fsn_ti CL:0000540 pr 2012-12-19T16:53:50Z True cellular_component owl:Class
GO:2001202 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000941 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900920 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002036 biolink:NamedThing regulation of L-glutamate import across plasma membrane Any process that modulates the frequency, rate or extent of L-glutamate import into a cell. got7fsn_ti regulation of L-glutamate uptake|regulation of L-glutamate transport|regulation of L-glutamate import al 2012-06-13T07:34:08Z GO:1900920 biological_process owl:Class
GO:0001043 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045788 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042831 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015455 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901368 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072026 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030480 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004647 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045081 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071850 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008577 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052251 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016927 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048121 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044757 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052853 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044433 biolink:NamedThing obsolete cytoplasmic vesicle part OBSOLETE. Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0031410 True cellular_component owl:Class
GO:0075516 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005857 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090196 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072610 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048435 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051533 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903813 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010534 biolink:NamedThing got7fsn_ti True owl:Class
GO:0023015 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061488 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004975 biolink:NamedThing got7fsn_ti True owl:Class
GO:0106287 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051910 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042028 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099159 biolink:NamedThing regulation of modification of postsynaptic structure Any process that modulates the frequency, rate or extent of modification of postsynaptic structure. got7fsn_ti regulation of postsynapse remodelling dos 2017-08-25T15:47:55Z biological_process owl:Class
GO:0048428 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001201 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071634 biolink:NamedThing regulation of transforming growth factor beta production Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta. got7fsn_ti regulation of transforming growth factor-beta production|regulation of TGFbeta production|regulation of TGF-B production|regulation of TGFB production|regulation of transforming growth factor-beta secretion|regulation of TGF-beta production mah 2010-02-12T10:33:07Z GO:2001201 biological_process owl:Class
GO:0032521 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052269 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007177 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072406 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006319 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044426 biolink:NamedThing obsolete cell wall part OBSOLETE. Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005618 True cellular_component owl:Class
GO:0045452 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044369 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016302 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018346 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990541 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006843 biolink:NamedThing mitochondrial citrate transmembrane transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix. got7fsn_ti mitochondrial citrate transport vw 2014-11-19T11:08:45Z GO:1990541 biological_process owl:Class
GO:0047523 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031188 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051806 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042348 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090233 biolink:NamedThing negative regulation of spindle checkpoint Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle. got7fsn_ti spindle checkpoint silencing Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). tb 2010-01-20T10:29:43Z biological_process owl:Class
GO:0071997 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015431 biolink:NamedThing ABC-type glutathione S-conjugate transporter activity Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out). got7fsn_ti conjugate transporter activity|ATP-dependent glutathione S-conjugate export pump|MRP1/GS-X pump|GS-X pump|ATPase-coupled glutathione S-conjugate transmembrane transporter activity|glutathione S-conjugate-exporting ATPase activity|glutathione S-conjugate-transporting ATPase activity mah 2010-10-25T02:32:02Z GO:0071997 RHEA:19121|EC:7.6.2.3 molecular_function owl:Class
GO:0031548 biolink:NamedThing regulation of brain-derived neurotrophic factor receptor signaling pathway Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway. got7fsn_ti regulation of BDNF receptor signaling pathway|regulation of brain-derived neurotrophic factor receptor signalling pathway|regulation of BDNF receptor signalling pathway biological_process owl:Class
GO:0043239 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033035 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099158 biolink:NamedThing regulation of recycling endosome localization within postsynapse Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse. got7fsn_ti dos 2017-08-25T15:37:50Z biological_process owl:Class
GO:0042517 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052388 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038125 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031574 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098929 biolink:NamedThing extrinsic component of spine apparatus membrane The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti cellular_component owl:Class
GO:0000420 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030349 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008223 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990240 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900040 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008699 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001136 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990289 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042384 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075146 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045361 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032692 biolink:NamedThing negative regulation of interleukin-1 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production. got7fsn_ti negative regulation of interleukin-1 biosynthetic process|down regulation of interleukin-1 production|inhibition of interleukin-1 production|downregulation of interleukin-1 production|negative regulation of interleukin-1 secretion|negative regulation of IL-1 production|down-regulation of interleukin-1 production GO:0045361|GO:0050711 biological_process owl:Class
GO:0071145 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098939 biolink:NamedThing dendritic transport of mitochondrion The directed movement of mitochondria along microtubules in nerve cell dendrites. got7fsn_ti biological_process owl:Class
GO:0090479 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031572 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061491 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098718 biolink:NamedThing serine import across plasma membrane The directed movement of serine from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti serine import into cell dph 2012-12-06T14:55:29Z GO:0061491 biological_process owl:Class
GO:0031675 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052518 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102567 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032313 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061461 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903719 biolink:NamedThing regulation of I-kappaB phosphorylation Any process that modulates the frequency, rate or extent of I-kappaB phosphorylation. got7fsn_ti regulation of IKB phosphorylation|regulation of IkappaB phosphorylation|regulation of inhibitor of kappaB phosphorylation|regulation of inhibitor of NF-kappaB phosphorylation lb 2014-12-08T15:45:07Z biological_process owl:Class
GO:1902094 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901912 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098674 biolink:NamedThing extrinsic component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti dos 2017-01-17T16:20:56Z cellular_component owl:Class
GO:0004404 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044763 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030357 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070362 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019106 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016951 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099188 biolink:NamedThing postsynaptic cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. got7fsn_ti dos 2017-12-20T15:06:57Z biological_process owl:Class
GO:0000975 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043869 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006765 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015938 biolink:NamedThing coenzyme A catabolic process The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. got7fsn_ti CoA catabolism|coenzyme A degradation|coenzyme A catabolism|coenzyme A breakdown GO:0006765 biological_process owl:Class
GO:0034273 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042298 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043986 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017191 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016481 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006827 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098938 biolink:NamedThing actin cytoskeleton of dendritic spine The actin cytoskeleton that is part of a dendritic spine. got7fsn_ti cellular_component owl:Class
GO:0019201 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018093 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019613 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905055 biolink:NamedThing calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. got7fsn_ti calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels dos 2016-03-17T14:35:35Z molecular_function owl:Class
GO:0072411 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006138 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001102 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045791 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034262 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905078 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030360 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016489 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001179 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050725 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042522 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000499 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007467 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045384 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048119 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003981 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016789 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072471 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050475 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090525 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032661 biolink:NamedThing regulation of interleukin-18 production Any process that modulates the frequency, rate, or extent of interleukin-18 production. got7fsn_ti regulation of interleukin-18 biosynthetic process|regulation of IL-18 production|regulation of interleukin-18 secretion GO:0150120|GO:0045381 biological_process owl:Class
GO:0071150 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070793 biolink:NamedThing regulation of conidiophore development Any process that modulates the frequency, rate or extent of conidiophore development, a process that leads to the formation of a conidiophore. The conidiophore is a specialized hypha that extends aerially from the growth substrate and bears conidia, or asexual spores. got7fsn_ti mah 2009-07-08T03:04:29Z biological_process owl:Class
GO:0016510 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032731 biolink:NamedThing positive regulation of interleukin-1 beta production Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. got7fsn_ti upregulation of interleukin-1 beta production|activation of interleukin-1 beta production|up regulation of interleukin-1 beta production|positive regulation of IL-1 beta production|stimulation of interleukin-1 beta production|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of interleukin-1 beta secretion|up-regulation of interleukin-1 beta production GO:0050718|GO:0050725 biological_process owl:Class
GO:0042678 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030918 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009599 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006321 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903807 biolink:NamedThing L-threonine import across plasma membrane The directed movement of L-threonine from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti L-threonine uptake|L-threonine import into cell|L-threonine import bf 2012-05-11T10:46:21Z GO:0036231 biological_process owl:Class
GO:0042503 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019421 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030407 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905076 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901134 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060257 biolink:NamedThing negative regulation of flocculation Any process that decreases the rate, frequency or extent of the non-sexual aggregation of single-celled organisms. got7fsn_ti negative regulation of coflocculation https://github.com/geneontology/go-ontology/issues/20192|https://github.com/geneontology/go-ontology/issues/18785 al 2012-07-12T07:17:11Z GO:1901134 biological_process owl:Class
GO:0052294 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019188 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035786 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902837 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048128 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050712 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990204 biolink:NamedThing oxidoreductase complex Any protein complex that possesses oxidoreductase activity. got7fsn_ti redox complex|oxidation-reduction complex bhm 2013-10-07T08:24:47Z cellular_component owl:Class
GO:0036232 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903808 biolink:NamedThing L-tyrosine import across plasma membrane The directed movement of L-tyrosine from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti L-tyrosine import into cell|L-tyrosine uptake|L-tyrosine import bf 2012-05-11T10:46:21Z GO:0036232 biological_process owl:Class
GO:0008708 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072428 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017031 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052567 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030524 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044246 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003889 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044797 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902536 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075141 biolink:NamedThing obsolete symbiont tolerance to host environment OBSOLETE. Any process that contributes to the maintenance of a physiologic state in which the symbiont immune system does not react destructively against the components of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti maintenance of symbiont tolerance to host iron concentration|maintenance of symbiont tolerance to host pH environment|maintenance of symbiont tolerance to host oxygen tension environment|maintenance of symbiont tolerance to host environment|maintenance of symbiont tolerance to host osmotic environment|maintenance of symbiont tolerance to host redox environment https://github.com/geneontology/go-ontology/issues/19099|https://github.com/geneontology/go-ontology/issues/18827 This term was obsoleted because it is redundant with other terms. GO:0052200 True GO:0075144|GO:0075238|GO:0075146|GO:0075143|GO:0075142 biological_process owl:Class
GO:0007544 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010173 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009364 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034048 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018476 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990126 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019587 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046397 biolink:NamedThing galacturonate catabolic process The chemical reactions and pathways resulting in the breakdown of galacturonate, the anion of galacturonic acid. got7fsn_ti galacturonate breakdown|galacturonate catabolism|galacturonate degradation GO:0019587 biological_process owl:Class
GO:0001593 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043689 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072458 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043092 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902658 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902657 biolink:NamedThing protein localization to prospore membrane A process in which a protein is transported to, or maintained in, a location within a prospore membrane. got7fsn_ti protein-prospore membrane targeting|establishment of protein localization to prospore membrane|protein localisation in prospore membrane|protein localisation to prospore membrane|protein targeting to prospore membrane|protein targeting to forespore membrane|protein targeting to FSM|establishment of protein localisation to prospore membrane|establishment of protein localization in prospore membrane|establishment of protein localisation in prospore membrane|protein targeting to ascospore-type prospore membrane|protein localization in prospore membrane dph 2011-11-16T11:28:26Z GO:1902658|GO:0072693 biological_process owl:Class
GO:0044086 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048234 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044370 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008749 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099522 biolink:NamedThing cytosolic region Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol. got7fsn_ti region of cytosol cellular_component owl:Class
GO:0003124 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038126 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051824 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045447 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902477 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018385 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090623 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001203 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004279 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004293 biolink:NamedThing obsolete tissue kallikrein activity OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds. got7fsn_ti salivary kallikrein|padutin|tissue kallikrein activity|kininogenin activity|glandular kallikrein activity|kallidinogenase|glumorin|submandibular kallikrein|padreatin|onokrein P|pancreatic kallikrein|urokallikrein|kidney kallikrein|depot-padutin|bradykininogenase|urinary kallikrein|callicrein|submaxillary kallikrein|kininogenase|dilminal D GO:0004252 This term was made obsolete because it represents a gene product. True GO:0004279 molecular_function owl:Class
GO:0048426 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018348 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001103 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042833 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070754 biolink:NamedThing regulation of interleukin-35 production Any process that modulates the frequency, rate, or extent of interleukin-35 production. got7fsn_ti regulation of IL-35 production|regulation of interleukin-35 biosynthetic process mah 2009-06-23T01:29:17Z GO:0070750 biological_process owl:Class
GO:0042055 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001048 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901977 biolink:NamedThing negative regulation of cell cycle checkpoint Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle checkpoint. got7fsn_ti downregulation of cell cycle checkpoint|negative regulation of G1/S transition checkpoint|down regulation of cell cycle checkpoint|down-regulation of cell cycle checkpoint|negative regulation of G1/S checkpoint|inhibition of cell cycle checkpoint Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). jl 2013-03-06T15:10:29Z GO:2001048 biological_process owl:Class
GO:0150134 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032713 biolink:NamedThing negative regulation of interleukin-4 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production. got7fsn_ti down regulation of interleukin-4 production|negative regulation of interleukin-4 biosynthetic process|inhibition of interleukin-4 production|negative regulation of interleukin-4 secretion|down-regulation of interleukin-4 production|negative regulation of IL-4 production|downregulation of interleukin-4 production bc GO:0150134|GO:0045403 biological_process owl:Class
GO:0016283 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018468 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905950 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043081 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005529 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061165 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016280 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010576 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045380 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032740 biolink:NamedThing positive regulation of interleukin-17 production Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines. got7fsn_ti activation of interleukin-17 production|upregulation of interleukin-17 production|stimulation of interleukin-17 production|positive regulation of interleukin-17 secretion|positive regulation of CTLA-8 production|positive regulation of interleukin-17 biosynthetic process|positive regulation of Cytotoxic T-lymphocyte-associated antigen 8 production|up regulation of interleukin-17 production|up-regulation of interleukin-17 production|positive regulation of IL-17 production GO:0045380|GO:1905078 biological_process owl:Class
GO:0019077 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001031 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071158 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042172 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007587 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016983 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018842 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001623 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099190 biolink:NamedThing postsynaptic spectrin-associated cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse. got7fsn_ti dos 2017-12-20T15:34:26Z biological_process owl:Class
GO:0005116 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009387 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090478 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045407 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902506 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008599 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043787 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004752 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044531 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007373 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032134 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008952 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001138 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903308 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097286 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072323 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008433 biolink:NamedThing got7fsn_ti True owl:Class
GO:0080138 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045405 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033317 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042591 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044749 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004718 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046698 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904497 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004646 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990939 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019052 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045423 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032645 biolink:NamedThing regulation of granulocyte macrophage colony-stimulating factor production Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. got7fsn_ti regulation of GM-CSF production|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of granulocyte macrophage colony stimulating factor production GO:0045423 biological_process owl:Class
GO:0044123 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030542 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903128 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007233 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016940 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045154 biolink:NamedThing got7fsn_ti True owl:Class
GO:0062178 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140252 biolink:NamedThing regulation protein catabolic process at postsynapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. got7fsn_ti https://github.com/geneontology/synapse/issues/204 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T10:35:56Z biological_process owl:Class
GO:0052509 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007330 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009370 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033724 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009281 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048432 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007151 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003895 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032750 biolink:NamedThing positive regulation of interleukin-26 production Any process that activates or increases the frequency, rate, or extent of interleukin-26 production. got7fsn_ti upregulation of interleukin-26 production|positive regulation of IL-26 production|activation of interleukin-26 production|up-regulation of interleukin-26 production|up regulation of interleukin-26 production|positive regulation of interleukin-26 biosynthetic process|stimulation of interleukin-26 production GO:0045538 biological_process owl:Class
GO:0015683 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016478 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043089 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036439 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048558 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052329 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048220 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043351 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990373 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140564 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051833 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032514 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052069 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034623 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090631 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097481 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001024 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048412 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099181 biolink:NamedThing structural constituent of presynapse The action of a molecule that contributes to the structural integrity of a presynapse. got7fsn_ti dos 2017-12-20T13:42:46Z molecular_function owl:Class
GO:0035856 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048178 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009391 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030387 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052385 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004695 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042295 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000351 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005103 biolink:NamedThing got7fsn_ti True owl:Class
GO:0103053 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060871 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009572 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044039 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019425 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006752 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006732 biolink:NamedThing obsolete coenzyme metabolic process OBSOLETE. The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. got7fsn_ti coenzyme metabolism|group transfer coenzyme metabolism|group transfer coenzyme metabolic process|coenzyme and prosthetic group metabolic process|coenzyme and prosthetic group metabolism 1. Making inferences in GO about compounds based on the coenzyme role curated by ChEBI creates relationships that are not always true which violates ontological principles for GO; therefore we will cease making these inferences. 2. It is not meaningful to group metabolic processes that are not all metabolically related by the fact that they may be used as a coenzyme. True GO:0006752 biological_process owl:Class
GO:0003708 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000021 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052311 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000823 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046756 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031794 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032859 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006764 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015937 biolink:NamedThing coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. got7fsn_ti coenzyme A anabolism|coenzyme A biosynthesis|CoA biosynthesis|coenzyme A formation|coenzyme A synthesis GO:0006764 MetaCyc:PANTOSYN-PWY|MetaCyc:COA-PWY|MetaCyc:PWY-4221 biological_process owl:Class
GO:0046735 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070805 biolink:NamedThing regulation of phialide development Any process that modulates the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. got7fsn_ti mah 2009-07-08T04:45:03Z biological_process owl:Class
GO:0090622 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016001 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001205 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046764 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009797 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001220 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006985 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033710 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072434 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052551 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008095 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902705 biolink:NamedThing hexose catabolic process to butyrate The chemical reactions and pathways resulting in the breakdown of hexose to butyrate. got7fsn_ti acidogenesis|hexose catabolism to butyrate|hexose degradation to butyrate|hexose breakdown to butyrate tb 2014-02-19T18:43:32Z GO:1990287 biological_process owl:Class
GO:0045360 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032652 biolink:NamedThing regulation of interleukin-1 production Any process that modulates the frequency, rate, or extent of interleukin-1 production. got7fsn_ti regulation of interleukin-1 biosynthetic process|regulation of interleukin-1 secretion|regulation of IL-1 production GO:0050704|GO:0045360 biological_process owl:Class
GO:0030928 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002217 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071435 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045235 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140236 biolink:NamedThing translation at presynapse Translation that occurs at the presynapse. got7fsn_ti https://github.com/geneontology/synapse/issues/216 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-13T13:00:33Z biological_process owl:Class
GO:0019754 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051577 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150135 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032753 biolink:NamedThing positive regulation of interleukin-4 production Any process that activates or increases the frequency, rate, or extent of interleukin-4 production. got7fsn_ti positive regulation of IL-4 production|upregulation of interleukin-4 production|positive regulation of interleukin-4 secretion|positive regulation of interleukin-4 biosynthetic process|up regulation of interleukin-4 production|stimulation of interleukin-4 production|activation of interleukin-4 production|up-regulation of interleukin-4 production GO:0150135|GO:0045404 biological_process owl:Class
GO:0052284 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048267 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150122 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006453 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070128 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033681 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052345 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990283 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042916 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072474 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002739 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002718 biolink:NamedThing regulation of cytokine production involved in immune response Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response. got7fsn_ti regulation of cytokine production during immune response|regulation of cytokine biosynthetic process involved in immune response|regulation of cytokine secretion involved in immune response GO:0002739|GO:0002742 biological_process owl:Class
GO:0090544 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030454 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042223 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046953 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000506 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019378 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042553 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042674 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045398 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032747 biolink:NamedThing positive regulation of interleukin-23 production Any process that activates or increases the frequency, rate, or extent of interleukin-23 production. got7fsn_ti activation of interleukin-23 production|up regulation of interleukin-23 production|positive regulation of IL-23 production|stimulation of interleukin-23 production|upregulation of interleukin-23 production|up-regulation of interleukin-23 production|positive regulation of interleukin-23 biosynthetic process GO:0045398 biological_process owl:Class
GO:1990944 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048607 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000505 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001047 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901976 biolink:NamedThing regulation of cell cycle checkpoint Any process that modulates the frequency, rate or extent of cell cycle checkpoint. got7fsn_ti regulation of G1/S checkpoint|regulation of G1/S transition checkpoint Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). jl 2013-03-06T15:10:20Z GO:2001047 biological_process owl:Class
GO:0000397 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901546 biolink:NamedThing regulation of synaptic vesicle lumen acidification Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification. got7fsn_ti regulation of synaptic vesicle lumen proton loading|regulation of synaptic vesicle lumen pH reduction dsf 2012-10-26T16:09:24Z biological_process owl:Class
GO:0008308 biolink:NamedThing voltage-gated anion channel activity Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-dependent ion-selective channel activity|voltage-gated ion-selective channel activity GO:0022844 Reactome:R-HSA-9012374 molecular_function owl:Class
GO:0030608 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075058 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018931 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016315 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008557 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090468 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090607 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018691 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902702 biolink:NamedThing hexose catabolic process to propan-2-ol The chemical reactions and pathways resulting in the breakdown of hexose to propan-2-ol. got7fsn_ti hexose catabolic process to isopropyl alcohol|hexose degradation to propan-2-ol|solventogenesis|hexose breakdown to propan-2-ol|hexose catabolism to propan-2-ol|hexose catabolic process to isopropanol tb 2014-02-19T18:42:54Z GO:1990283 biological_process owl:Class
GO:1990681 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009775 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036064 biolink:NamedThing ciliary basal body A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport. got7fsn_ti kinetosome|cilium basal body|basal body|microtubule basal body|cilial basal body In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. bf 2011-12-15T10:40:20Z GO:0005932 NIF_Subcellular:sao11978067 cellular_component owl:Class
GO:0009121 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007514 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046795 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090005 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905060 biolink:NamedThing calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. got7fsn_ti calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels dos 2016-03-18T12:32:17Z molecular_function owl:Class
GO:0045365 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003280 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031183 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048221 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904168 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097405 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098714 biolink:NamedThing malate import across plasma membrane The directed movement of malate from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti malate import into cell pr 2012-10-29T11:18:48Z GO:0097405 biological_process owl:Class
GO:1901603 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052153 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070970 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900921 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045909 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001645 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072693 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006994 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050702 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016066 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075057 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045419 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032758 biolink:NamedThing positive regulation of interleukin-9 production Any process that activates or increases the frequency, rate, or extent of interleukin-9 production. got7fsn_ti up-regulation of interleukin-9 production|upregulation of interleukin-9 production|up regulation of interleukin-9 production|positive regulation of interleukin-9 biosynthetic process|positive regulation of IL-9 production|activation of interleukin-9 production|stimulation of interleukin-9 production GO:0045419 biological_process owl:Class
GO:0016448 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903956 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008400 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098611 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000998 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052298 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046613 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072605 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005661 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003892 biolink:NamedThing obsolete proliferating cell nuclear antigen OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair. got7fsn_ti proliferating cell nuclear antigen|PCNA This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. True GO:0005661 molecular_function owl:Class
GO:0032709 biolink:NamedThing negative regulation of interleukin-25 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production. got7fsn_ti down-regulation of interleukin-25 production|downregulation of interleukin-25 production|inhibition of interleukin-25 production|negative regulation of interleukin-25 secretion|negative regulation of IL-25 production|down regulation of interleukin-25 production|negative regulation of interleukin-25 biosynthetic process GO:0150149|GO:0045533 biological_process owl:Class
GO:0089711 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045385 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032702 biolink:NamedThing negative regulation of interleukin-19 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production. got7fsn_ti down regulation of interleukin-19 production|negative regulation of IL-19 production|negative regulation of interleukin-19 biosynthetic process|inhibition of interleukin-19 production|down-regulation of interleukin-19 production|downregulation of interleukin-19 production GO:0045385 biological_process owl:Class
GO:0019175 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052469 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033817 biolink:NamedThing got7fsn_ti True owl:Class
GO:0047318 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075008 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904360 biolink:NamedThing negative regulation of spore germination Any process that stops, prevents or reduces the frequency, rate or extent of spore germination. got7fsn_ti negative regulation of spore germination on or near host|downregulation of spore germination|down regulation of spore germination|down-regulation of spore germination|inhibition of spore germination pf 2015-06-12T19:46:12Z GO:0075008 biological_process owl:Class
GO:0045400 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006993 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035105 biolink:NamedThing obsolete sterol regulatory element binding protein import into nucleus OBSOLETE. The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes. got7fsn_ti SREBP import into nucleus involved in sterol depletion response|sterol depletion response, sterol regulatory element binding protein import into nucleus|sterol regulatory element binding protein import into nucleus involved in sterol depletion response|sterol depletion response, SREBP import into nucleus|SREBP import into nucleus|SREBP nuclear translocation|sterol depletion response, SREBP nuclear translocation|sterol regulatory element binding protein nuclear translocation|sterol depletion response, sterol regulatory element binding protein nuclear translocation|sterol regulatory element binding protein nuclear translocation involved in sterol depletion response The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. GO:0042306|GO:0006606 True GO:0006993 biological_process owl:Class
GO:0007328 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003890 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005339 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015008 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005699 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016425 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019127 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002163 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005069 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032842 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052271 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098675 biolink:NamedThing intrinsic component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to neuronal dense core granule membrane dos 2017-01-17T16:22:44Z cellular_component owl:Class
GO:0015815 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045374 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000066 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990575 biolink:NamedThing mitochondrial L-ornithine transmembrane transport The process in which L-ornithine is transported across a mitochondrial membrane, into or out of the mitochondrion. got7fsn_ti mitochondrial ornithine transport|mitochondrial ornithine transmembrane transport mah 2014-12-05T11:29:49Z GO:0000066 biological_process owl:Class
GO:0002740 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022833 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000443 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007333 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140079 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016949 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001157 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015785 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015584 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042782 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060553 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052077 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000364 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030871 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051207 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902251 biolink:NamedThing negative regulation of erythrocyte apoptotic process Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process. got7fsn_ti downregulation of RBC apoptotic process|down-regulation of RBC apoptosis|down regulation of RBC apoptotic process|down regulation of RBC apoptosis|inhibition of erythrocyte apoptotic process|down-regulation of erythrocyte apoptotic process|down regulation of red blood cell apoptotic process|down-regulation of erythrocyte apoptosis|inhibition of erythrocyte apoptosis|downregulation of RBC apoptosis|negative regulation of erythrocyte apoptosis|down regulation of erythrocyte apoptosis|down regulation of erythrocyte apoptotic process|inhibition of red blood cell apoptotic process|down-regulation of red blood cell apoptosis|downregulation of red blood cell apoptotic process|inhibition of RBC apoptosis|downregulation of red blood cell apoptosis|negative regulation of RBC apoptotic process|negative regulation of red blood cell apoptosis|inhibition of RBC apoptotic process|down-regulation of red blood cell apoptotic process|negative regulation of RBC apoptosis|down-regulation of RBC apoptotic process|downregulation of erythrocyte apoptotic process|downregulation of erythrocyte apoptosis|down regulation of red blood cell apoptosis|inhibition of red blood cell apoptosis|negative regulation of red blood cell apoptotic process rl 2013-06-20T19:30:59Z biological_process owl:Class
GO:0015819 biolink:NamedThing lysine transport The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti lysine uptake|L-lysine transport|lysine import|L-lysine import dph 2012-10-05T10:22:26Z GO:0034226|GO:0061461 biological_process owl:Class
GO:0005325 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004926 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018368 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018086 biolink:NamedThing obsolete alanine racemization OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti alanine racemization This term was made obsolete because it was replaced with more appropriate terms. GO:0019122 True GO:0018368 biological_process owl:Class
GO:0015618 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005471 biolink:NamedThing ATP:ADP antiporter activity Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). got7fsn_ti ATP/ADP exchanger|ADP/ATP translocase|adenine nucleotide translocase|ADP/ATP carrier protein|ATP/ADP exchange GO:0005349 molecular_function owl:Class
GO:0005286 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071156 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008054 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052441 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072516 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015027 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005478 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990598 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038049 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001183 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051812 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904190 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006819 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075128 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044798 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015672 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033205 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019663 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045733 biolink:NamedThing acetate catabolic process The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid. got7fsn_ti homoacetate catabolic process|acetate breakdown|acetate catabolism|acetate degradation GO:0019663 biological_process owl:Class
GO:0045406 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031182 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052304 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052382 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036277 biolink:NamedThing response to anticonvulsant Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. bf 2012-07-09T02:40:12Z biological_process owl:Class
GO:0010531 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003749 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090569 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048470 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061164 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006773 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008614 biolink:NamedThing pyridoxine metabolic process The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate. got7fsn_ti pyridoxine metabolism GO:0006773 biological_process owl:Class
GO:0047607 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000355 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042514 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042005 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002641 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004863 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008426 biolink:NamedThing protein kinase C inhibitor activity Binds to and stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein. got7fsn_ti PKC inhibitor activity|diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity|diacylglycerol-activated phospholipid-dependent PKC inhibitor activity GO:0004863 molecular_function owl:Class
GO:1902582 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015681 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006309 biolink:NamedThing apoptotic DNA fragmentation The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. got7fsn_ti DNA catabolism during apoptosis|chromatinolysis|DNA fragmentation|endonucleolytic DNA catabolic process involved in apoptosis|DNA fragmentation involved in apoptotic nuclear change|DNA catabolic process during apoptosis DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). GO:0008178 biological_process owl:Class
GO:0016982 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044117 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006087 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042502 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032845 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033318 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015991 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099102 biolink:NamedThing G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential. got7fsn_ti molecular_function owl:Class
GO:0048112 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045817 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008520 biolink:NamedThing L-ascorbate:sodium symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-ascorbate(out) + Na+(out) = L-ascorbate(in) + Na+(in). got7fsn_ti sodium-dependent L-ascorbic acid transporter|sodium-dependent L-ascorbate transmembrane transporter activity mah 2009-09-01T02:25:22Z GO:0070890 TC:2.A.40.6.1 molecular_function owl:Class
GO:1990286 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003748 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000383 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098945 biolink:NamedThing intrinsic component of presynaptic active zone membrane The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to presynaptic acive zone membrane cellular_component owl:Class
GO:0001140 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048113 biolink:NamedThing got7fsn_ti True owl:Class
GO:0020021 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016685 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044422 biolink:NamedThing obsolete organelle part OBSOLETE. Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0043226 True cellular_component owl:Class
GO:0140160 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033733 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000484 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032757 biolink:NamedThing positive regulation of interleukin-8 production Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. got7fsn_ti positive regulation of interleukin-8 secretion|up regulation of interleukin-8 production|activation of interleukin-8 production|positive regulation of interleukin-8 biosynthetic process|up-regulation of interleukin-8 production|upregulation of interleukin-8 production|stimulation of interleukin-8 production|positive regulation of IL-8 production GO:2000484|GO:0045416 biological_process owl:Class
GO:0009774 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015197 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072620 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046733 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902368 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018735 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902302 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903764 biolink:NamedThing regulation of potassium ion export across plasma membrane Any process that modulates the frequency, rate or extent of potassium ion export across the plasma membrane. got7fsn_ti regulation of potassium ion export|regulation of potassium export|regulation of potassium export across plasma membrane rl 2013-07-17T16:39:53Z GO:1902302 biological_process owl:Class
GO:0008264 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043071 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008059 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016238 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018375 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902264 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015320 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015317 biolink:NamedThing phosphate:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in). got7fsn_ti phosphate:hydrogen symporter activity|phosphate ion carrier activity https://github.com/geneontology/go-ontology/issues/14221 GO:0015320 molecular_function owl:Class
GO:0052248 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044253 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045073 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001030 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102023 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046472 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097617 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004405 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072422 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007408 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990285 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035546 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003768 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048425 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015893 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004804 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006632 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099164 biolink:NamedThing postsynaptic specialization membrane of symmetric synapse The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. got7fsn_ti dos 2017-09-10T11:50:44Z cellular_component owl:Class
GO:0001187 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052852 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052378 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016142 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016139 biolink:NamedThing glycoside catabolic process The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound. got7fsn_ti O-glycoside catabolism|glycoside catabolism|glycoside degradation|glycoside breakdown|O-glycoside catabolic process|O-glycoside degradation|O-glycoside breakdown GO:0016142 biological_process owl:Class
GO:0045556 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061460 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903810 biolink:NamedThing L-histidine import across plasma membrane The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti histidine import|L-histidine import|L-histidine import into cell dph 2012-10-05T10:20:50Z GO:0061460|GO:0090466 biological_process owl:Class
GO:0002716 biolink:NamedThing negative regulation of natural killer cell mediated immunity Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity. got7fsn_ti negative regulation of natural killer cell activity|negative regulation of NK cell mediated immunity|downregulation of natural killer cell mediated immunity|inhibition of natural killer cell mediated immunity|down regulation of natural killer cell mediated immunity|down-regulation of natural killer cell mediated immunity|negative regulation of NK cell activity GO:0030102 biological_process owl:Class
GO:0018696 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045090 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033613 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007222 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000508 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048590 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042115 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052186 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052380 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099090 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043141 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019004 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009618 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015684 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015509 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004871 biolink:NamedThing obsolete signal transducer activity OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. got7fsn_ti quorum sensing signal generator activity|hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity|quorum sensing response regulator activity https://github.com/geneontology/go-ontology/issues/14232 This term was obsoleted because it was not clearly defined and is not a useful grouping term. True GO:0009370|GO:0009369|GO:0005062 molecular_function owl:Class
GO:0016961 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031888 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099531 biolink:NamedThing presynaptic process involved in chemical synaptic transmission The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. got7fsn_ti biological_process owl:Class
GO:1902699 biolink:NamedThing pentose catabolic process to acetate The chemical reactions and pathways resulting in the breakdown of pentose to acetate. got7fsn_ti pentose breakdown to acetate|acidogenesis|pentose degradation to acetate|pentose catabolism to acetate tb 2014-02-19T18:28:38Z GO:1990289 biological_process owl:Class
GO:0052082 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000068 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150121 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032701 biolink:NamedThing negative regulation of interleukin-18 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production. got7fsn_ti negative regulation of interleukin-18 secretion|inhibition of interleukin-18 production|downregulation of interleukin-18 production|down-regulation of interleukin-18 production|negative regulation of interleukin-18 biosynthetic process|down regulation of interleukin-18 production|negative regulation of IL-18 production GO:0045382|GO:0150121 biological_process owl:Class
GO:0015397 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046788 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060626 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060625 biolink:NamedThing regulation of protein deneddylation Any process that modulates the rate, frequency, or extent of protein deneddylation, the removal of a ubiquitin-like protein of the NEDD8 type from a protein. got7fsn_ti regulation of cullin deneddylation dph 2009-05-18T02:22:07Z GO:0060626 biological_process owl:Class
GO:0003752 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015077 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008040 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052259 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052310 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030390 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098955 biolink:NamedThing intrinsic component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to presynaptic endosome membrane cellular_component owl:Class
GO:0005299 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045357 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004429 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015637 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048287 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090004 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004012 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:9606 biolink:NamedThing got7fsn_ti owl:Class
GO:0099603 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019006 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003703 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048063 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007331 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019275 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036274 biolink:NamedThing response to lapatinib Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. bf 2012-07-09T02:02:26Z biological_process owl:Class
GO:0015456 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015022 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048157 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045389 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000317 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051025 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000119 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019723 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032861 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008402 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022838 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045207 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005620 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006262 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008604 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032729 biolink:NamedThing positive regulation of interferon-gamma production Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. got7fsn_ti upregulation of interferon-gamma production|up regulation of interferon-gamma production|positive regulation of type II interferon production|positive regulation of interferon-gamma secretion|up-regulation of interferon-gamma production|positive regulation of interferon-gamma biosynthetic process|activation of interferon-gamma production|stimulation of interferon-gamma production GO:0045078|GO:1902715 biological_process owl:Class
GO:0072511 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015660 biolink:NamedThing formate efflux transmembrane transporter activity Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane. got7fsn_ti formate efflux permease activity GO:0015509 molecular_function owl:Class
GO:0001012 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901238 biolink:NamedThing ABC-type tungstate transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + tungstate(in) = ADP + phosphate + tungstate(out). got7fsn_ti tungstate transmembrane transporter activity|ATPase-coupled tungstate transmembrane transporter activity|tungstate transmembrane-transporting ATPase activity jl 2012-08-07T14:47:36Z GO:1901237 EC:7.3.2.6|RHEA:35027 molecular_function owl:Class
GO:0004701 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000600 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099025 biolink:NamedThing anchored component of postsynaptic membrane The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. got7fsn_ti cellular_component owl:Class
GO:0003894 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003738 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043341 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070886 biolink:NamedThing positive regulation of calcineurin-NFAT signaling cascade Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade. got7fsn_ti up-regulation of calcineurin-NFAT signaling cascade|positive regulation of NFAT protein import into nucleus|stimulation of calcineurin-NFAT signaling cascade|activation of calcineurin-NFAT signaling cascade|up regulation of calcineurin-NFAT signaling cascade|positive regulation of calcineurin-NFAT signalling cascade|upregulation of calcineurin-NFAT signaling cascade|positive regulation of calcineurin-NFAT signaling pathway mah 2009-08-26T03:37:10Z GO:0051533 biological_process owl:Class
GO:0036275 biolink:NamedThing response to 5-fluorouracil Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus. got7fsn_ti response to fluorouracil|response to 5-fluoropyrimidine-2,4(1H,3H)-dione Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. bf 2012-07-09T02:08:23Z biological_process owl:Class
GO:0032698 biolink:NamedThing negative regulation of interleukin-15 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production. got7fsn_ti down regulation of interleukin-15 production|down-regulation of interleukin-15 production|downregulation of interleukin-15 production|negative regulation of IL-15 production|inhibition of interleukin-15 production|negative regulation of interleukin-15 biosynthetic process GO:0045373 biological_process owl:Class
GO:0018089 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018514 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009564 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010802 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001045 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097312 biolink:NamedThing obsolete bacterial biofilm matrix component OBSOLETE. Any constituent part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria. got7fsn_ti biofilm matrix part Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0097311 pr 2012-05-24T11:22:56Z True cellular_component owl:Class
GO:0019753 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031238 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900755 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005717 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052270 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044709 biolink:NamedThing got7fsn_ti True owl:Class
GO:2001182 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004469 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032192 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045386 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043026 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072419 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071974 biolink:NamedThing got7fsn_ti True owl:Class
GOP:syngo_official_label biolink:NamedThing label approved by the SynGO project got7fsn_ti owl:AnnotationProperty
GO:0140235 biolink:NamedThing RNA polyadenylation at postsynapse A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-13T12:03:28Z biological_process owl:Class
GO:0018999 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000824 biolink:NamedThing got7fsn_ti True owl:Class
GO:0047314 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052371 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007092 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015273 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032319 biolink:NamedThing got7fsn_ti True owl:Class
GO:0103019 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015239 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990292 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902697 biolink:NamedThing valine catabolic process to isobutanol The chemical reactions and pathways resulting in the breakdown of valine to isobutanol. got7fsn_ti valine breakdown to isobutanol|valine degradation to isobutanol|valine catabolism to isobutanol tb 2014-02-19T18:28:19Z GO:1990292 biological_process owl:Class
GO:0055099 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006317 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098999 biolink:NamedThing extrinsic component of postsynaptic endosome membrane The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti cellular_component owl:Class
GO:0075326 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903822 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005086 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001789 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007022 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099578 biolink:NamedThing regulation of translation at postsynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0098701 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017097 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090003 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072604 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005224 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045044 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015300 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016930 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048547 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001150 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034961 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010003 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010535 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008971 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008497 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042228 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001189 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001513 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061600 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016535 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045502 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008005 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071842 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004008 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016022 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007466 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001625 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001017 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090097 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045432 biolink:NamedThing got7fsn_ti True owl:Class
GO:0023046 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099577 biolink:NamedThing regulation of translation at presynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0017144 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072646 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052443 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050222 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031186 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031171 biolink:NamedThing ferricrocin biosynthetic process The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3. got7fsn_ti ferricrocin formation|ferricrocin synthesis|ferricrocin anabolism|ferricrocin biosynthetic process, peptide modification|ferricrocin biosynthetic process, peptide formation|ferricrocin biosynthesis GO:0031185|GO:0031186 biological_process owl:Class
GO:0072603 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015511 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070869 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035084 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045673 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019291 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004434 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018056 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044457 biolink:NamedThing obsolete cell septum part OBSOLETE. Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0030428 True cellular_component owl:Class
GO:0003765 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032725 biolink:NamedThing positive regulation of granulocyte macrophage colony-stimulating factor production Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production. got7fsn_ti positive regulation of GM-CSF production|activation of granulocyte macrophage colony-stimulating factor production|upregulation of granulocyte macrophage colony-stimulating factor production|stimulation of granulocyte macrophage colony-stimulating factor production|positive regulation of granulocyte macrophage colony stimulating factor production|up regulation of granulocyte macrophage colony-stimulating factor production|up-regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process GO:0045425 biological_process owl:Class
GO:0042095 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052263 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019225 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030347 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033109 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032318 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051546 biolink:NamedThing keratinocyte migration The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another. got7fsn_ti biological_process owl:Class
GO:0015788 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001032 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900136 biolink:NamedThing regulation of chemokine activity Any process that modulates the frequency, rate or extent of chemokine activity. got7fsn_ti bf 2012-02-28T01:36:29Z biological_process owl:Class
GO:1903717 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004280 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052000 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030396 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072622 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150133 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008522 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045426 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032746 biolink:NamedThing positive regulation of interleukin-22 production Any process that activates or increases the frequency, rate, or extent of interleukin-22 production. got7fsn_ti upregulation of interleukin-22 production|up regulation of interleukin-22 production|up-regulation of interleukin-22 production|activation of interleukin-22 production|stimulation of interleukin-22 production|positive regulation of IL-22 production|positive regulation of interleukin-22 biosynthetic process GO:0045395 biological_process owl:Class
GO:0060359 biolink:NamedThing response to ammonium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. got7fsn_ti response to ammonia GO:1903717 biological_process owl:Class
GO:0018380 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902453 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052936 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060403 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031192 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:27896 biolink:NamedThing got7fsn_ti owl:Class
GO:0008329 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008323 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102315 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045245 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015402 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902479 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008524 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061513 biolink:NamedThing glucose 6-phosphate:inorganic phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + inorganic phosphate(in) = glucose 6-phosphate(in) + inorganic phosphate(out). got7fsn_ti glucose 6-phosphate:phosphate antiporter activity dph 2013-04-17T08:47:40Z GO:0008524 Reactome:R-HSA-198513|Reactome:R-HSA-3229118|Reactome:R-HSA-3257122 molecular_function owl:Class
GO:1903129 biolink:NamedThing got7fsn_ti True owl:Class
GO:0022415 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032568 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005023 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097366 biolink:NamedThing response to bronchodilator Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes. got7fsn_ti response to broncholytic agent|response to bronchodilator agent Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. pr 2012-08-01T16:13:31Z biological_process owl:Class
GO:0001004 biolink:NamedThing obsolete RNA polymerase III transcription regulator recruiting activity OBSOLETE. Initiating the assembly of the RNA polymerase III pre-initiation complex by binding to a control sequence in the intragenic region. This allows to recruit TFIIIB to the DNA at a site centered approximately 26 base pairs upstream of the start site of transcription. For tRNA genes, TFIIIC first associates with DNA, and then recruits TFIIIB. For 5S rRNA genes, TFIIIA binds to DNA first, followed by TFIIIC, which then recruits TFIIIB. got7fsn_ti RNA polymerase III transcription factor recruiting activity|SNAPc-type activity|type 2 RNA polymerase III promoter recognition|transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting|type 3 RNA polymerase III promoter recognition|RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity|transcription factor activity, RNA polymerase III type 1 promoter TFIIIB|RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|RNA polymerase III assembly factor activity|RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity|transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting|RNA polymerase III assembly factor activity, TFIIIB recruiting|TFIIIC-type activity|transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting|TFIIIA activity|RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity|transcription factor activity, RNA polymerase III type 3 promoter TFIIIB recruiting https://github.com/geneontology/go-ontology/issues/18561|https://github.com/geneontology/go-ontology/issues/14852 The reason for obsoletion is that this function is redundant with other terms, most often 'transcription co-regulator activity; GO:0003712'. krc 2010-08-18T05:53:32Z True GO:0001038|GO:0001008|GO:0001033|GO:0001157|GO:0001005 molecular_function owl:Class
GO:0071775 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000283 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032659 biolink:NamedThing regulation of interleukin-16 production Any process that modulates the frequency, rate, or extent of interleukin-16 production. got7fsn_ti regulation of IL-16 production|regulation of interleukin-16 biosynthetic process GO:0045375 biological_process owl:Class
GO:0016792 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005659 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032695 biolink:NamedThing negative regulation of interleukin-12 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. got7fsn_ti downregulation of interleukin-12 production|negative regulation of interleukin-12 secretion|negative regulation of CLMF production|down-regulation of interleukin-12 production|negative regulation of NKSF production|down regulation of interleukin-12 production|negative regulation of IL-12 production|negative regulation of interleukin-12 biosynthetic process|inhibition of interleukin-12 production GO:0045083|GO:2001183 biological_process owl:Class
GO:0007332 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000753 biolink:NamedThing cell morphogenesis involved in conjugation with cellular fusion The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion. got7fsn_ti shmoo orientation|shmooing GO:0007332 biological_process owl:Class
GO:0032738 biolink:NamedThing positive regulation of interleukin-15 production Any process that activates or increases the frequency, rate, or extent of interleukin-15 production. got7fsn_ti activation of interleukin-15 production|stimulation of interleukin-15 production|upregulation of interleukin-15 production|up-regulation of interleukin-15 production|positive regulation of interleukin-15 biosynthetic process|up regulation of interleukin-15 production|positive regulation of IL-15 production GO:0045374 biological_process owl:Class
GO:0015338 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050663 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051526 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001053 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016987 biolink:NamedThing sigma factor activity Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. got7fsn_ti plastid sigma factor activity|bacterial sigma factor activity|DNA-dependent RNA polymerase promoter selection factor|core DNA-dependent RNA polymerase binding promoter specificity activity|sigma factor activity|sigma transcription factor|promoter selection factor activity https://github.com/geneontology/go-ontology/issues/14848|https://github.com/geneontology/go-ontology/issues/15587 krc 2010-08-11T04:12:24Z GO:0000996|GO:0001053 molecular_function owl:Class
GO:0045877 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061021 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052292 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052109 biolink:NamedThing obsolete induction by symbiont of defense-related host cell wall callose deposition OBSOLETE. Any process in which an organism activates, maintains or increases the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti up regulation by symbiont of defense-related host cell wall callose deposition|positive regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction|activation by symbiont of defense-related host cell wall callose deposition|upregulation by symbiont of defense-related host cell wall callose deposition|positive regulation by symbiont of defense-related host cell wall callose deposition|positive regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction|up-regulation by symbiont of defense-related host cell wall callose deposition|positive regulation by symbiont of defense-related host callose deposition|stimulation by symbiont of defense-related host cell wall callose deposition This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. True GO:0052292|GO:0052291|GO:0052107 biological_process owl:Class
GO:0016599 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052101 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071578 biolink:NamedThing zinc ion import across plasma membrane The directed movement of zinc(2+) ions from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti zinc II ion plasma membrane import|zinc II ion transmembrane import|zinc uptake|low-affinity zinc II ion transport|zinc ion transmembrane import|high-affinity zinc II ion transport|zinc import|high-affinity zinc II ion transmembrane import jl 2010-01-28T02:22:02Z GO:0006831|GO:0044749|GO:0006830|GO:0140160 biological_process owl:Class
GO:0006263 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008698 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030344 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072617 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006300 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042536 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072083 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051406 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043764 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008338 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009670 biolink:NamedThing triose-phosphate:phosphate antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out). got7fsn_ti triose phosphate antiporter|dihydroxyacetone phosphate:phosphate antiporter activity|triose phosphate translocator|TPT GO:0015122 molecular_function owl:Class
GO:0048250 biolink:NamedThing iron import into the mitochondrion The process in which iron is transported from the cytosol into the mitochondrial matrix. got7fsn_ti mitochondrial iron ion transport|mitochondrial iron cation transmembrane transport|mitochondrial iron ion transmembrane transport|mitochondrial iron transport al 2016-02-10T11:24:22Z GO:1990925 biological_process owl:Class
GO:0016698 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904668 biolink:NamedThing positive regulation of ubiquitin protein ligase activity Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity. got7fsn_ti upregulation of ubiquitin ligase activity|up-regulation of ubiquitin protein ligase activity|up-regulation of E3|positive regulation of protein ubiquitination activity|activation of APC-fizzy related complex activity|activation of ubiquitin protein ligase activity|activation of E3|up regulation of E3|up-regulation of ubiquitin ligase activity|up regulation of ubiquitin protein ligase activity|positive regulation of APC-fizzy related complex activity|upregulation of APC-fizzy related complex activity|activation of protein ubiquitination activity|activation of APC-Cdc20 complex activity|up regulation of ubiquitin ligase activity|up-regulation of APC-fizzy related complex activity|positive regulation of E3|up regulation of APC-fizzy related complex activity|up-regulation of protein ubiquitination activity|upregulation of protein ubiquitination activity|upregulation of ubiquitin protein ligase activity|activation of ubiquitin ligase activity|up regulation of protein ubiquitination activity|positive regulation of ubiquitin ligase activity|upregulation of E3|activation of anaphase-promoting complex activity dph 2015-09-08T15:27:11Z GO:1903835|GO:0051488|GO:0007092|GO:0090623 biological_process owl:Class
GO:0001749 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004480 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030461 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004036 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099152 biolink:NamedThing regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. got7fsn_ti dos 2017-08-25T15:01:11Z biological_process owl:Class
GO:0008858 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006992 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098705 biolink:NamedThing copper ion import across plasma membrane The directed movement of copper ions from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti copper cation import into cell|high affinity copper ion transport|high-affinity copper ion transport|high affinity copper transport|copper ion import into cell mah 2014-04-03T13:26:04Z GO:1902861|GO:0015678 biological_process owl:Class
GO:0003891 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016224 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018409 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048603 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043681 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042145 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044714 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007104 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150188 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031744 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019746 biolink:NamedThing hopanoid biosynthetic process The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus. got7fsn_ti hopanoid synthesis|hopanoid anabolism|hopanoid biosynthesis|hopanoid formation biological_process owl:Class
GO:0001904 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051714 biolink:NamedThing positive regulation of cytolysis in other organism Any process that activates or increases the frequency, rate or extent of the cytolysis by an organism of cells in another organism. got7fsn_ti up regulation of cytolysis of cells of another organism|positive regulation of cytolysis of cells of another, non-host, organism|up-regulation of cytolysis of cells of another organism|stimulation of cytolysis of cells of another organism|positive regulation of cytolysis of cells of another organism|activation of cytolysis of cells of another organism|upregulation of cytolysis of cells of another organism GO:0001904 biological_process owl:Class
GO:0016000 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904621 biolink:NamedThing got7fsn_ti True owl:Class
GO:0085031 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010237 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045077 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032689 biolink:NamedThing negative regulation of interferon-gamma production Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. got7fsn_ti negative regulation of type II interferon production|down-regulation of interferon-gamma production|negative regulation of interferon-gamma biosynthetic process|down regulation of interferon-gamma production|downregulation of interferon-gamma production|negative regulation of interferon-gamma secretion|inhibition of interferon-gamma production GO:0045077|GO:1902714 biological_process owl:Class
GO:0000360 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015581 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016195 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070969 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043809 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006831 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042507 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006095 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005067 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072612 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031187 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019259 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002245 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052301 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015646 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052556 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017132 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017048 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072509 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015936 biolink:NamedThing coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. got7fsn_ti coenzyme A metabolism|CoA metabolism GO:0006763 biological_process owl:Class
GO:1990152 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051535 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030610 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017036 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006318 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019913 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005454 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048025 biolink:NamedThing negative regulation of mRNA splicing, via spliceosome Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism. got7fsn_ti down-regulation of nuclear mRNA splicing via U2-type spliceosome|negative regulation of nuclear mRNA splicing via U2-type spliceosome|down regulation of nuclear mRNA splicing via U2-type spliceosome|down-regulation of nuclear mRNA splicing, via spliceosome|down regulation of nuclear mRNA splicing, via spliceosome|downregulation of nuclear mRNA splicing, via spliceosome|inhibition of nuclear mRNA splicing via U2-type spliceosome|negative regulation of pre-mRNA splicing|negative regulation of nuclear mRNA splicing, via spliceosome|downregulation of nuclear mRNA splicing via U2-type spliceosome|inhibition of nuclear mRNA splicing, via spliceosome GO:0035056 biological_process owl:Class
GO:0150150 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038005 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072420 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072638 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045255 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097249 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005720 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102101 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004907 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061039 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019945 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006345 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903820 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046971 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000507 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007262 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033216 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035117 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043234 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000141 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098738 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044259 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060555 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099243 biolink:NamedThing extrinsic component of synaptic membrane The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti dos 2017-05-25T17:24:23Z cellular_component owl:Class
GO:0044699 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031206 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005288 biolink:NamedThing got7fsn_ti True owl:Class
GO:2000483 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032717 biolink:NamedThing negative regulation of interleukin-8 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production. got7fsn_ti down-regulation of interleukin-8 production|negative regulation of IL-8 production|downregulation of interleukin-8 production|inhibition of interleukin-8 production|negative regulation of interleukin-8 secretion|negative regulation of interleukin-8 biosynthetic process|down regulation of interleukin-8 production GO:2000483|GO:0045415 biological_process owl:Class
GO:0008006 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052369 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007456 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006092 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046991 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035620 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006951 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048427 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009430 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098835 biolink:NamedThing presynaptic endocytic zone membrane The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release. got7fsn_ti cellular_component owl:Class
GO:1902861 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090484 biolink:NamedThing got7fsn_ti True owl:Class
GO:0140242 biolink:NamedThing translation at postsynapse Translation that occurs at the postsynapse. got7fsn_ti https://github.com/geneontology/synapse/issues/210 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-15T09:26:27Z biological_process owl:Class
GO:0001106 biolink:NamedThing got7fsn_ti True owl:Class
GO:0060247 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016244 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016196 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099056 biolink:NamedThing integral component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral component of presynaptic plasma membrane cellular_component owl:Class
GO:0044274 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015586 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098695 biolink:NamedThing inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. got7fsn_ti IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels dos 2017-04-04T17:07:09Z molecular_function owl:Class
GO:0048233 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043361 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902361 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006850 biolink:NamedThing mitochondrial pyruvate transmembrane transport The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion. got7fsn_ti pyruvate transmembrane transport in mitochondria|pyruvate membrane transport in mitochondrion|pyruvate membrane transport in mitochondria|mitochondrial pyruvate transport|pyruvate transmembrane transport in mitochondrion dph 2013-08-15T11:19:35Z GO:1902361 biological_process owl:Class
GO:1903809 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004524 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990369 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019353 biolink:NamedThing protoporphyrinogen IX biosynthetic process from glutamate The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate. got7fsn_ti protoporphyrinogen IX synthesis from glutamate|protoporphyrinogen IX formation from glutamate|protoporphyrinogen IX anabolism from glutamate biological_process owl:Class
GO:0048474 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061012 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044670 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008862 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043142 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018692 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070882 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042520 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015071 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052565 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046746 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008723 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099033 biolink:NamedThing anchored component of postsynaptic recycling endosome membrane The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. got7fsn_ti cellular_component owl:Class
GO:0150043 biolink:NamedThing structural constituent of synapse-associated extracellular matrix The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. got7fsn_ti synapse-associated extracellular matrix structural constituent|extra-synaptic extracellular matrix structural constituent|structural constituent of extra-synaptic extracellular matrix bc 2018-04-19T13:42:40Z molecular_function owl:Class
GO:0072614 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044713 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016023 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008416 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007325 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051836 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003893 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032653 biolink:NamedThing regulation of interleukin-10 production Any process that modulates the frequency, rate, or extent of interleukin-10 production. got7fsn_ti regulation of interleukin-10 secretion|regulation of interleukin-10 biosynthetic process|regulation of IL-10 production GO:0045074|GO:2001179 biological_process owl:Class
GO:0046770 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051226 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990552 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990550 biolink:NamedThing mitochondrial alpha-ketoglutarate transmembrane transport The process in which alpha-ketoglutarate is transported across a mitochondrial membrane, into or out of the mitochondrion. got7fsn_ti mitochondrial 2-oxoglutarate transmembrane transport vw 2014-11-19T12:11:59Z GO:1990552 biological_process owl:Class
GO:0035430 biolink:NamedThing regulation of gluconate transmembrane transport Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore. got7fsn_ti regulation of gluconate membrane transport|regulation of gluconate transport bf 2010-04-08T10:37:18Z GO:0032893 biological_process owl:Class
GO:0009776 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102568 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001521 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009341 biolink:NamedThing beta-galactosidase complex A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. got7fsn_ti cellular_component owl:Class
GO:0031576 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000074 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052483 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035030 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045416 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990774 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098890 biolink:NamedThing extrinsic component of postsynaptic membrane The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti cellular_component owl:Class
GO:0052262 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008601 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016924 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001085 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001021 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902825 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905647 biolink:NamedThing proline import across plasma membrane The directed movement of proline from outside of a cell into the cytoplasmic compartment. got7fsn_ti proline import into cell mah 2014-03-31T13:14:04Z GO:1902825 biological_process owl:Class
GO:0045206 biolink:NamedThing obsolete MAPK phosphatase transporter activity OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells. got7fsn_ti MAPK phosphatase transporter activity|MKP shuttle|leptomycin B-sensitive MKP shuttle|leptomycin B-sensitive MAPK phosphatase transporter activity This term was made obsolete because we do not know what it was intended to represent when it was created. True GO:0045207 molecular_function owl:Class
GO:0009796 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034449 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000004 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005605 biolink:NamedThing got7fsn_ti True owl:Class
GO:0097638 biolink:NamedThing L-arginine import across plasma membrane The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti arginine import|L-arginine import into cell tb 2012-09-24T14:28:58Z GO:1902765|GO:0090467 biological_process owl:Class
GO:0002391 biolink:NamedThing platelet activating factor production involved in inflammatory response The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. got7fsn_ti platelet activating factor secretion|platelet activating factor secretion involved in inflammatory response|platelet activating factor production involved in acute inflammatory response|platelet activating factor production|platelet activating factor secretion involved in acute inflammatory response https://github.com/geneontology/go-ontology/issues/20154 GO:0002390|GO:0002535|GO:0002392 biological_process owl:Class
GO:0007061 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006347 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001643 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008067 biolink:NamedThing obsolete metabotropic glutamate, GABA-B-like receptor activity OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor. got7fsn_ti metabotropic glutamate, GABA-B-like receptor activity|class C G-protein coupled receptor|class C orphan receptor activity|class C GPCR|class C G protein coupled receptor This term was made obsolete because it represents a gene product and is named based on protein features. True GO:0001643|GO:0001645 molecular_function owl:Class
GO:1902713 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016449 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045941 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902440 biolink:NamedThing protein localization to mitotic spindle pole body A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body. got7fsn_ti protein localisation in mitotic spindle pole body|protein localization in mitotic spindle pole body|protein localisation to mitotic spindle pole body|establishment of protein localization to mitotic spindle pole body mah 2013-10-10T14:44:55Z GO:1990975 biological_process owl:Class
GO:0021734 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044463 biolink:NamedThing obsolete cell projection part OBSOLETE. Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0042995 True cellular_component owl:Class
GO:0010251 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003705 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016350 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046393 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001210 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043346 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045034 biolink:NamedThing obsolete neuroblast division OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell. got7fsn_ti neuroblast division|neuroblast division (sensu Vertebrata)|neuroblast division (sensu Nematoda and Protostomia)|neuroblast cell division This term was made obsolete because the definition was incorrect. Not all neuroblasts divide asymmetrically. Neuroblasts give rise to neurons after division. True GO:0043345|GO:0043346 biological_process owl:Class
GO:0070683 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045082 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904359 biolink:NamedThing regulation of spore germination Any process that modulates the frequency, rate or extent of spore germination. got7fsn_ti modulation of spore germination on or near host pf 2015-06-12T19:46:06Z GO:0075006 biological_process owl:Class
GO:0042456 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008606 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008896 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050715 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902778 biolink:NamedThing response to alkane Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkane stimulus. got7fsn_ti process resulting in tolerance to alkane GO:1990373 biological_process owl:Class
GO:0090457 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090513 biolink:NamedThing L-histidine transmembrane import into vacuole The directed movement of L-histidine into the vacuole across the vacuolar membrane. got7fsn_ti vacuolar histidine import|histidine transmembrane import into vacuole tb 2012-12-14T11:25:52Z GO:0090457 biological_process owl:Class
GO:0015906 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072600 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004884 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001158 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072447 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099144 biolink:NamedThing anchored component of synaptic membrane The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. got7fsn_ti dos 2017-05-25T17:25:19Z cellular_component owl:Class
GO:0005101 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051689 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043222 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016194 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032863 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007243 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002375 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005830 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045079 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006652 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044464 biolink:NamedThing obsolete cell part OBSOLETE. Any constituent part of a cell, the basic structural and functional unit of all organisms. got7fsn_ti protoplast|cellular subcomponent Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. CL:0000000 True NIF_Subcellular:sao628508602 cellular_component owl:Class
GO:0097024 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018917 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044401 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051183 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007001 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015290 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008624 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045412 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016766 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004041 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050719 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045403 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045845 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016097 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050375 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016523 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015058 biolink:NamedThing obsolete epidermal growth factor-like module containing hormone receptor activity OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti epidermal growth factor-like module containing hormone receptor activity|EGF-like module containing hormone receptor activity|Egr1 hormone receptor This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. True GO:0016523 molecular_function owl:Class
GO:0016249 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046846 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042936 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010302 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005232 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043340 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901138 biolink:NamedThing got7fsn_ti True owl:Class
GOP:chebi_ph7_3 biolink:NamedThing got7fsn_ti Rhea list of ChEBI terms representing the major species at pH 7.3. owl:AnnotationProperty
GO:0044368 biolink:NamedThing got7fsn_ti True owl:Class
GO:0102609 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007184 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044366 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004302 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042872 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150156 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048551 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044432 biolink:NamedThing obsolete endoplasmic reticulum part OBSOLETE. Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. got7fsn_ti ER component Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0005783 True cellular_component owl:Class
GO:0044442 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044441 biolink:NamedThing obsolete ciliary part OBSOLETE. Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. got7fsn_ti flagellum part|cilial part|flagellum component|flagellar part|microtubule-based flagellum part|cilium part Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent. GO:0005929 True GO:0044442 cellular_component owl:Class
GO:0042828 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007326 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010708 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046906 biolink:NamedThing tetrapyrrole binding Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. got7fsn_ti porphyrin binding molecular_function owl:Class
GO:1902540 biolink:NamedThing got7fsn_ti True owl:Class
GO:1901243 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016294 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048186 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090155 biolink:NamedThing negative regulation of sphingolipid biosynthetic process Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). got7fsn_ti negative regulation of sphingolipid biosynthesis involved in cellular sphingolipid homeostasis tb 2009-12-08T03:33:39Z GO:0090157 biological_process owl:Class
GO:0051807 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905659 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044006 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005062 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075238 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016953 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010993 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072455 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006395 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015659 biolink:NamedThing got7fsn_ti True owl:Class
GO:0103052 biolink:NamedThing got7fsn_ti True owl:Class
GO:0090526 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006111 biolink:NamedThing regulation of gluconeogenesis Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. got7fsn_ti regulation of gluconeogenesis involved in cellular glucose homeostasis|regulation of glucose biosynthetic process|regulation of glucose biosynthesis tb 2013-01-18T12:47:43Z GO:0090526 biological_process owl:Class
GO:0102260 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046744 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015502 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019968 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044152 biolink:NamedThing got7fsn_ti True owl:Class
GO:0039676 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042107 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099240 biolink:NamedThing intrinsic component of synaptic membrane The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to synaptic membrane dos 2017-05-25T17:23:21Z cellular_component owl:Class
GO:0007335 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001078 biolink:NamedThing got7fsn_ti True owl:Class
GO:1990296 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007404 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019109 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015992 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030914 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000361 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048042 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000029 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015365 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045417 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048253 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043147 biolink:NamedThing got7fsn_ti True owl:Class
GO:0055133 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900172 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071845 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072404 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099092 biolink:NamedThing postsynaptic density, intracellular component A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. got7fsn_ti cellular_component owl:Class
GO:0043790 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005453 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005468 biolink:NamedThing obsolete small-molecule carrier or transporter OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti small-molecule carrier or transporter This term was made obsolete because it does not provide a useful functional classification. GO:0005215 True GO:0005454|GO:0005453 molecular_function owl:Class
GO:0000996 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902520 biolink:NamedThing response to doxorubicin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a doxorubicin stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. dw 2013-12-02T09:44:13Z biological_process owl:Class
GO:0051856 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017160 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902150 biolink:NamedThing got7fsn_ti True owl:Class
GO:0035734 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072569 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905965 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001600 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006519 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016400 biolink:NamedThing got7fsn_ti True owl:Class
GO:0070872 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099550 biolink:NamedThing trans-synaptic signaling, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. got7fsn_ti Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. biological_process owl:Class
GO:0046748 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098993 biolink:NamedThing anchored component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. got7fsn_ti cellular_component owl:Class
GO:0019965 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003946 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008032 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008680 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006966 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015411 biolink:NamedThing ABC-type taurine transporter transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in). got7fsn_ti taurine-transporting ATPase activity|taurine ABC transporter|ATPase-coupled taurine transporter activity|ATP-dependent taurine transporter activity https://github.com/geneontology/go-ontology/issues/21640 MetaCyc:ABC-64-RXN|RHEA:14613|EC:7.6.2.7|MetaCyc:3.6.3.36-RXN molecular_function owl:Class
GO:0003699 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043091 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030333 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045413 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072459 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015222 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000778 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002640 biolink:NamedThing got7fsn_ti True owl:Class
GO:0080039 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015235 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072641 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034259 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903758 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052566 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010577 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007322 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046616 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043167 biolink:NamedThing ion binding Binding to an ion, a charged atoms or groups of atoms. got7fsn_ti atom binding molecular_function owl:Class
GO:0019850 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018932 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900041 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098923 biolink:NamedThing retrograde trans-synaptic signaling by soluble gas Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand. got7fsn_ti biological_process owl:Class
GO:0001041 biolink:NamedThing got7fsn_ti True owl:Class
GO:0016431 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032512 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044461 biolink:NamedThing obsolete bacterial-type flagellum part OBSOLETE. Any constituent part of the bacterial-type flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by a transmembrane ion potential, typically a proton or sodium potential. got7fsn_ti flagellin-based flagellum part Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0009288 True cellular_component owl:Class
GO:0005974 biolink:NamedThing obsolete fibrinogen gamma chain OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti fibrinogen gamma chain This term was made obsolete because it represents a single gene product and not a complex. GO:0005577 True GO:0008007 cellular_component owl:Class
GO:0003760 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000942 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902706 biolink:NamedThing hexose catabolic process to acetate The chemical reactions and pathways resulting in the breakdown of hexose to acetate. got7fsn_ti hexose degradation to acetate|acidogenesis|hexose breakdown to acetate|hexose catabolism to acetate tb 2014-02-19T18:43:23Z GO:1990286 biological_process owl:Class
GO:0022817 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008183 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000356 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042530 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048141 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006645 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072510 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045376 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015202 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098667 biolink:NamedThing got7fsn_ti True owl:Class
GO:0061166 biolink:NamedThing got7fsn_ti True owl:Class
GO:0051372 biolink:NamedThing got7fsn_ti True owl:Class
NCBITaxon:6237 biolink:NamedThing got7fsn_ti owl:Class
GO:0036271 biolink:NamedThing response to methylphenidate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus. got7fsn_ti response to ritalin|response to MPH|response to MPD Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. bf 2012-07-09T01:30:57Z biological_process owl:Class
GO:0009021 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032403 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045420 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032643 biolink:NamedThing regulation of connective tissue growth factor production Any process that modulates the frequency, rate, or extent of connective tissue growth factor production. got7fsn_ti regulation of Hcs24 production|regulation of IGFBP8 production|regulation of CTGF production|regulation of connective tissue growth factor biosynthetic process|regulation of Fisp12 production|regulation of hypertrophic chondrocyte-specific gene product 24 production|regulation of CCN2 production GO:0045420 biological_process owl:Class
GO:0009287 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002422 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015379 biolink:NamedThing potassium:chloride symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). got7fsn_ti potassium ion symporter activity GO:0022820 Reactome:R-HSA-426155|Reactome:R-HSA-5623806 molecular_function owl:Class
GO:0052533 biolink:NamedThing got7fsn_ti True owl:Class
GO:0019537 biolink:NamedThing vibriobactin biosynthetic process The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae. got7fsn_ti vibriobactin synthesis|vibriobactin biosynthetic process, peptide modification|vibriobactin biosynthesis|vibriobactin formation|vibriobactin anabolism|vibriobactin biosynthetic process, peptide formation GO:0031195|GO:0031196 biological_process owl:Class
GO:0042505 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042231 biolink:NamedThing got7fsn_ti True owl:Class
GO:0055134 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004199 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030693 biolink:NamedThing obsolete caspase activity OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue. got7fsn_ti caspase-6 activity|effector caspase activity|caspase-4 activity|caspase activity|caspase-9 activity|signaling (initiator) caspase activity|caspase-7 activity|caspase-2 activity|caspase-1 activity|caspase-10 activity|caspase-8 activity|caspase-5 activity|caspase-3 activity GO:0004197 This term was made obsolete because it represents a gene product. True GO:0004199 molecular_function owl:Class
GO:0009031 biolink:NamedThing got7fsn_ti True owl:Class
GO:0055128 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006866 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005486 biolink:NamedThing got7fsn_ti True owl:Class
GO:0018176 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099055 biolink:NamedThing integral component of postsynaptic membrane The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti cellular_component owl:Class
GO:0005100 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000173 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042525 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032748 biolink:NamedThing positive regulation of interleukin-24 production Any process that activates or increases the frequency, rate, or extent of interleukin-24 production. got7fsn_ti positive regulation of IL-24 production|activation of interleukin-24 production|up regulation of interleukin-24 production|upregulation of interleukin-24 production|stimulation of interleukin-24 production|positive regulation of interleukin-24 biosynthetic process|up-regulation of interleukin-24 production GO:0045536 biological_process owl:Class
GO:0015784 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042097 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032855 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009369 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008249 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004762 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045790 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044447 biolink:NamedThing obsolete axoneme part OBSOLETE. Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. got7fsn_ti axonemal part Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Also note that cilia and eukaryotic flagella are deemed to be equivalent. GO:0005930 True cellular_component owl:Class
GO:0098961 biolink:NamedThing dendritic transport of ribonucleoprotein complex The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites. got7fsn_ti dendritic transport of RNP complex biological_process owl:Class
GO:0072652 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046715 biolink:NamedThing active borate transmembrane transporter activity Enables the transport of borate across a membrane against the concentration gradient. got7fsn_ti boron uptake transmembrane transporter activity|efflux-type borate transporter|efflux-type boron transporter|borate uptake transmembrane transporter activity|boron transmembrane transporter activity|borate transmembrane transporter activity dhl 2009-05-19T04:09:56Z GO:0080138 molecular_function owl:Class
GO:0048125 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150054 biolink:NamedThing regulation of postsynaptic neurotransmitter receptor diffusion trapping Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping. got7fsn_ti bc 2018-05-10T14:26:59Z biological_process owl:Class
GO:0042238 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904623 biolink:NamedThing got7fsn_ti True owl:Class
GO:0120081 biolink:NamedThing obsolete positive regulation of microfilament motor activity OBSOLETE. Any process that activates or increases the frequency, rate or extent of microfilament motor activity. got7fsn_ti positive regulation of myosin ATPase activity|positive regulation of actin-activated ATPase activity|positive regulation of actin-filament motor activity|positive regulation of actin filament motor activity|activation of actin-dependent ATPase activity|positive regulation of actin-dependent ATPase activity|positive regulation of muscle motor activity|activation of actin-activated ATPase activity|upregulation of actin-dependent ATPase activity https://github.com/geneontology/go-ontology/issues/20877|https://github.com/geneontology/go-ontology/issues/21626 This term was obsoleted because it represents a molecular function. GO:0140660 krc 2017-07-05T21:48:56Z True GO:1904623 biological_process owl:Class
GO:0044765 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031196 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045526 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003826 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045440 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050720 biolink:NamedThing got7fsn_ti True owl:Class
GO:0098894 biolink:NamedThing extrinsic component of presynaptic endocytic zone membrane The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. got7fsn_ti cellular_component owl:Class
GO:0043355 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005218 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042977 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017115 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000391 biolink:NamedThing got7fsn_ti True owl:Class
GO:0036281 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044115 biolink:NamedThing got7fsn_ti True owl:Class
GO:0004188 biolink:NamedThing obsolete serine-type Pro-X carboxypeptidase activity OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid. got7fsn_ti proline carboxypeptidase activity|serine-type Pro-X carboxypeptidase activity|peptidylprolylamino acid carboxypeptidase activity|proline-specific carboxypeptidase P|lysosomal Pro-X carboxypeptidase activity|lysosomal Pro-Xaa carboxypeptidase activity|prolyl carboxypeptidase activity|lysosomal carboxypeptidase C activity|aminoacylproline carboxypeptidase activity|angiotensinase C activity|PCP GO:0004185 This term was made obsolete because it represents a gene product. True GO:0008323 molecular_function owl:Class
GO:0008372 biolink:NamedThing got7fsn_ti True owl:Class
GO:0150126 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905121 biolink:NamedThing got7fsn_ti True owl:Class
GO:0045867 biolink:NamedThing got7fsn_ti True owl:Class
GO:0043018 biolink:NamedThing got7fsn_ti True owl:Class
GO:0046388 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072407 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033218 biolink:NamedThing amide binding Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. got7fsn_ti molecular_function owl:Class
GO:0015028 biolink:NamedThing got7fsn_ti True owl:Class
GO:0008827 biolink:NamedThing got7fsn_ti True owl:Class
GO:1903765 biolink:NamedThing negative regulation of potassium ion export across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion export across the plasma membrane. got7fsn_ti inhibition of potassium export|downregulation of potassium ion export across plasma membrane|inhibition of potassium ion export across plasma membrane|inhibition of potassium ion export|down regulation of potassium ion export|down-regulation of potassium ion export across plasma membrane|negative regulation of potassium ion export|negative regulation of potassium export|down-regulation of potassium export|down-regulation of potassium ion export|down regulation of potassium export|downregulation of potassium export|down regulation of potassium ion export across plasma membrane|downregulation of potassium ion export rl 2013-07-17T16:40:02Z GO:1902303 biological_process owl:Class
GO:0090699 biolink:NamedThing got7fsn_ti True owl:Class
GO:1905539 biolink:NamedThing regulation of postsynapse to nucleus signaling pathway Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway. got7fsn_ti regulation of postsynaptic signaling to nucleus dos 2016-10-07T17:03:38Z biological_process owl:Class
GO:1903989 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015656 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042109 biolink:NamedThing got7fsn_ti True owl:Class
GO:0050716 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032732 biolink:NamedThing positive regulation of interleukin-1 production Any process that activates or increases the frequency, rate, or extent of interleukin-1 production. got7fsn_ti up regulation of interleukin-1 production|up-regulation of interleukin-1 production|positive regulation of interleukin-1 secretion|positive regulation of interleukin-1 biosynthetic process|stimulation of interleukin-1 production|upregulation of interleukin-1 production|activation of interleukin-1 production|positive regulation of IL-1 production GO:0045362|GO:0050716 biological_process owl:Class
GO:0030609 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042683 biolink:NamedThing negative regulation of compound eye cone cell fate specification Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell. got7fsn_ti down-regulation of cone cell fate specification|down regulation of cone cell fate specification|inhibition of cone cell fate specification|suppression of cone cell fate|downregulation of cone cell fate specification GO:0010000 biological_process owl:Class
GO:0140237 biolink:NamedThing translation at presynapse, modulating chemical synaptic transmission Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. got7fsn_ti https://github.com/geneontology/synapse/issues/216 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. pg 2018-07-13T13:07:23Z biological_process owl:Class
GO:0099057 biolink:NamedThing integral component of presynaptic endocytic zone membrane The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti cellular_component owl:Class
GO:0048272 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000058 biolink:NamedThing got7fsn_ti True owl:Class
GO:0000056 biolink:NamedThing ribosomal small subunit export from nucleus The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm. got7fsn_ti ribosomal small subunit export from cell nucleus|ribosomal small subunit transport from nucleus to cytoplasm|ribosomal small subunit export out of nucleus|40S ribosomal subunit export from nucleus|30S ribosomal subunit export from nucleus|ribosomal small subunit-nucleus export GO:0000058 biological_process owl:Class
GO:0102017 biolink:NamedThing got7fsn_ti True owl:Class
GO:0047767 biolink:NamedThing got7fsn_ti True owl:Class
GO:0005098 biolink:NamedThing got7fsn_ti True owl:Class
GO:0002214 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044021 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052282 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052202 biolink:NamedThing obsolete negative regulation by symbiont of defense-related host cell wall callose deposition OBSOLETE. Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the deposition of callose by the host in its cell walls, occurring as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti downregulation by symbiont of defense-related host cell wall callose deposition|negative regulation by organism of defense-related callose deposition in other organism involved in symbiotic interaction|inhibition by symbiont of defense-related host cell wall callose deposition|negative regulation by organism of defense-related cell wall callose deposition in other organism involved in symbiotic interaction|down regulation by symbiont of defense-related host cell wall callose deposition|down-regulation by symbiont of defense-related host cell wall callose deposition|negative regulation by symbiont of defense-related host callose deposition This term was obsoleted because it is a host, not a symbiont process, but was formulated as a symbiont process. True GO:0052282|GO:0052087|GO:0052311 biological_process owl:Class
GO:0009259 biolink:NamedThing ribonucleotide metabolic process The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. got7fsn_ti ribonucleotide metabolism GO:0009121 biological_process owl:Class
GO:0031191 biolink:NamedThing got7fsn_ti True owl:Class
GO:0010553 biolink:NamedThing got7fsn_ti True owl:Class
GO:0033225 biolink:NamedThing ATPase-coupled 2-aminoethylphosphonate transporter activity Enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other by catalysis of the reaction: ATP + H2O + 2-aminoethylphosphonate(out) = ADP + phosphate + 2-aminoethylphosphonate(in). got7fsn_ti 2-aminoethylphosphonate transporting ATPase activity|2-phosphonoethylamine transmembrane transporter activity|ciliatine transportingATPase activity|2-phosphonoethylamine transporting ATPase activity|2-aminoethylphosphonate transmembrane transporter activity|ATP-dependent 2-aminoethylphosphonate transporter activity|2-aminoethylphosphonate-transporting ATPase activity|ciliatine transporter activity There is no annotated example of this MF; therefore we cannot classify it more precisely. GO:0033224 RHEA:32775 molecular_function owl:Class
GO:0015245 biolink:NamedThing fatty acid transmembrane transporter activity Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. got7fsn_ti fatty acyl transporter activity|fatty-acyl group transporter activity|peroxisomal fatty acyl transporter|fatty acid transporter activity GO:0015246 Reactome:R-HSA-5627891|Reactome:R-HSA-879585 molecular_function owl:Class
GO:0005040 biolink:NamedThing got7fsn_ti True owl:Class
GO:1904167 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006160 biolink:NamedThing got7fsn_ti True owl:Class
GO:0001146 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030966 biolink:NamedThing got7fsn_ti True owl:Class
GO:0075710 biolink:NamedThing got7fsn_ti True owl:Class
GO:0030646 biolink:NamedThing got7fsn_ti True owl:Class
GO:0017100 biolink:NamedThing got7fsn_ti True owl:Class
GO:0048365 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052099 biolink:NamedThing got7fsn_ti True owl:Class
GO:0038044 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044252 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902478 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900425 biolink:NamedThing negative regulation of defense response to bacterium Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium. got7fsn_ti negative regulation of defense response to bacterium, incompatible interaction|downregulation of defense response to bacterium|negative regulation of defence response to bacteria|inhibition of defence response to bacteria|inhibition of defense response to bacterium|down-regulation of defense response to bacteria|down-regulation of defense response to bacterium|down-regulation of defence response to bacterium|inhibition of defence response to pathogenic bacterium, incompatible interaction|down-regulation of defence response to bacteria|down regulation of defense response to bacteria|inhibition of resistance response to pathogenic bacteria|inhibition of defence response to bacterium|downregulation of defence response to bacterium|down regulation of defense response to bacterium|downregulation of defense response to bacteria|downregulation of defence response to bacteria|inhibition of response to pathogenic bacterium (incompatible interaction)|inhibition of defense response to bacterium, incompatible interaction|down regulation of antibacterial peptide activity|inhibition of defense response to bacteria|inhibition of resistance response to pathogenic bacterium|down regulation of defence response to bacterium|inhibition of antibacterial peptide activity|negative regulation of defense response to bacteria|down regulation of defence response to bacteria|inhibition of defence response to pathogenic bacteria, incompatible interaction|down-regulation of antibacterial peptide activity|downregulation of antibacterial peptide activity|negative regulation of defence response to bacterium|inhibition of response to pathogenic bacteria (incompatible interaction)|negative regulation of antibacterial peptide activity dhl 2012-04-24T10:12:54Z GO:1902478 biological_process owl:Class
GO:0015177 biolink:NamedThing got7fsn_ti True owl:Class
GO:0072425 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032699 biolink:NamedThing negative regulation of interleukin-16 production Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production. got7fsn_ti negative regulation of interleukin-16 biosynthetic process|downregulation of interleukin-16 production|negative regulation of IL-16 production|inhibition of interleukin-16 production|down-regulation of interleukin-16 production|down regulation of interleukin-16 production GO:0045376 biological_process owl:Class
GO:0150130 biolink:NamedThing got7fsn_ti True owl:Class
GO:0099165 biolink:NamedThing postsynaptic specialization of symmetric synapse, intracellular component A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses. got7fsn_ti dos 2017-09-10T11:54:15Z cellular_component owl:Class
GO:0042002 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044462 biolink:NamedThing obsolete external encapsulating structure part OBSOLETE. Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria). got7fsn_ti Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. GO:0030312 True cellular_component owl:Class
GO:0006344 biolink:NamedThing got7fsn_ti True owl:Class
GO:0080080 biolink:NamedThing got7fsn_ti True owl:Class
GO:0007513 biolink:NamedThing got7fsn_ti True owl:Class
GO:0009552 biolink:NamedThing got7fsn_ti True owl:Class
GO:0006461 biolink:NamedThing got7fsn_ti True owl:Class
GO:0032864 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902149 biolink:NamedThing got7fsn_ti True owl:Class
GO:1902147 biolink:NamedThing regulation of response to cytokinesis checkpoint signaling Any process that modulates the frequency, rate or extent of response to cytokinesis checkpoint signaling. got7fsn_ti regulation of response to signal involved in cytokinesis checkpoint|regulation of cytokinesis checkpoint effector process jl 2013-05-21T15:43:53Z GO:1902149 biological_process owl:Class
GO:1905120 biolink:NamedThing cellular response to haloperidol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a haloperidol stimulus. got7fsn_ti Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. It was created to be used for cross-referencing by other ontologies. Direct annotations to this term may be amended during annotation QC. dw 2016-04-08T12:36:47Z biological_process owl:Class
GO:0098587 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044723 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003742 biolink:NamedThing got7fsn_ti True owl:Class
GO:0042033 biolink:NamedThing got7fsn_ti True owl:Class
GO:0031988 biolink:NamedThing got7fsn_ti True owl:Class
GO:0015318 biolink:NamedThing inorganic molecular entity transmembrane transporter activity Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. got7fsn_ti inorganic solute uptake transmembrane transporter activity|inorganic uptake permease activity https://github.com/geneontology/go-ontology/issues/14372 molecular_function owl:Class
GO:0098963 biolink:NamedThing dendritic transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites. got7fsn_ti dendritic transport of mRNA RNP complex biological_process owl:Class
GO:0000799 biolink:NamedThing got7fsn_ti True owl:Class
GO:0044704 biolink:NamedThing got7fsn_ti True owl:Class
GO:0071776 biolink:NamedThing got7fsn_ti True owl:Class
GO:0052068 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900390 biolink:NamedThing got7fsn_ti True owl:Class
GO:0034756 biolink:NamedThing regulation of iron ion transport Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti regulation of iron transport|regulation of iron import|regulation of iron ion import|regulation of Fe transport mah 2012-04-18T04:00:14Z GO:1900390 biological_process owl:Class
GO:0008072 biolink:NamedThing got7fsn_ti True owl:Class
GO:1900173 biolink:NamedThing got7fsn_ti True owl:Class
GO:0003354 biolink:NamedThing negative regulation of cilium movement Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium. got7fsn_ti negative regulation of microtubule-based flagellum movement|negative regulation of flagellum movement Note that we deem cilium and microtubule-based flagellum to be equivalent. dph 2009-12-03T10:17:47Z GO:1900173 biological_process owl:Class
GO:0070110 biolink:NamedThing ciliary neurotrophic factor receptor complex A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR. got7fsn_ti cellular_component owl:Class
GO:0120015 biolink:NamedThing sterol transfer activity Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. got7fsn_ti sterol carrier activity|intermembrane sterol transfer activity https://github.com/geneontology/go-ontology/issues/12329 krc 2017-03-17T03:46:28Z molecular_function owl:Class
GO:0014905 biolink:NamedThing myoblast fusion involved in skeletal muscle regeneration A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. got7fsn_ti biological_process owl:Class
GO:1903000 biolink:NamedThing regulation of lipid transport across blood-brain barrier Any process that modulates the frequency, rate or extent of lipid transport across blood-brain barrier. got7fsn_ti regulation of lipid transport across blood brain barrier sjp 2014-05-09T09:30:04Z biological_process owl:Class
GO:0110162 biolink:NamedThing regulation of mitotic spindle elongation (spindle phase three) Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase three). got7fsn_ti kmv 2019-08-12T15:26:01Z biological_process owl:Class
GO:0016345 biolink:NamedThing female meiotic chromosome movement towards spindle pole The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis. got7fsn_ti female meiotic chromosome movement|female meiotic chromosome movement to spindle pole|chromosome movement towards spindle pole during female meiosis biological_process owl:Class
GO:1903201 biolink:NamedThing regulation of oxidative stress-induced cell death Any process that modulates the frequency, rate or extent of oxidative stress-induced cell death. got7fsn_ti regulation of cell death in response to oxidative stress bf 2014-07-21T16:10:30Z biological_process owl:Class
GO:0015105 biolink:NamedThing arsenite transmembrane transporter activity Enables the transfer of arsenite from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0045943 biolink:NamedThing positive regulation of transcription by RNA polymerase I Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. got7fsn_ti activation of transcription from RNA polymerase I promoter|up-regulation of transcription from RNA polymerase I promoter|stimulation of transcription from RNA polymerase I promoter|positive regulation of transcription from RNA polymerase I promoter|up regulation of transcription from RNA polymerase I promoter|positive regulation of transcription from Pol I promoter|upregulation of transcription from RNA polymerase I promoter biological_process owl:Class
GO:0099049 biolink:NamedThing clathrin coat assembly involved in endocytosis The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation. got7fsn_ti biological_process owl:Class
GO:0098906 biolink:NamedThing regulation of Purkinje myocyte action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels. got7fsn_ti tb 2011-11-10T08:58:56Z biological_process owl:Class
GO:2000590 biolink:NamedThing negative regulation of metanephric mesenchymal cell migration Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration. got7fsn_ti negative regulation of metanephric mesenchyme chemotaxis bf 2011-04-07T03:29:49Z biological_process owl:Class
GO:0033221 biolink:NamedThing ATPase-coupled urea transmembrane transporter activity Catalysis of the reaction: ATP + H2O + urea(out) = ADP + phosphate + urea(in). got7fsn_ti urea-transporting ATPase activity|carbamide-transporting ATPase activity|ATP-dependent urea transmembrane transporter activity RHEA:32803 molecular_function owl:Class
GO:0071918 biolink:NamedThing urea transmembrane transport The process in which urea, the water-soluble compound H2N-CO-NH2, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. got7fsn_ti urea membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. mah 2010-09-24T10:41:36Z biological_process owl:Class
GO:0071231 biolink:NamedThing cellular response to folic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. got7fsn_ti response to folate|response to vitamin B9 mah 2009-12-03T02:08:32Z biological_process owl:Class
GO:0071329 biolink:NamedThing cellular response to sucrose stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus. got7fsn_ti mah 2009-12-10T05:31:22Z biological_process owl:Class
GO:1904175 biolink:NamedThing positive regulation of histone demethylase activity (H3-K4 specific) Any process that activates or increases the frequency, rate or extent of histone demethylase activity (H3-K4 specific). got7fsn_ti up regulation of histone demethylase activity (H3-K4 specific)|upregulation of histone demethylase activity (H3-K4 specific)|activation of histone demethylase activity (H3-K4 specific)|up-regulation of histone demethylase activity (H3-K4 specific) dph 2015-04-24T19:29:45Z biological_process owl:Class
GO:0042479 biolink:NamedThing positive regulation of eye photoreceptor cell development Any process that activates or increases the frequency, rate or extent of eye photoreceptor development. got7fsn_ti stimulation of eye photoreceptor cell development|upregulation of eye photoreceptor cell development|up regulation of eye photoreceptor cell development|activation of eye photoreceptor cell development|positive regulation of eye photoreceptor development|up-regulation of eye photoreceptor cell development biological_process owl:Class
GO:1901551 biolink:NamedThing negative regulation of endothelial cell development Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development. got7fsn_ti down regulation of endothelial cell development|down-regulation of endothelial cell development|downregulation of endothelial cell development|inhibition of endothelial cell development pr 2012-10-30T12:59:54Z biological_process owl:Class
GO:0033300 biolink:NamedThing dehydroascorbic acid transmembrane transporter activity Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other. got7fsn_ti dehydroascorbic acid transporter activity|dehydroascorbate transporter activity RHEA:60380|Reactome:R-HSA-198818 molecular_function owl:Class
GO:1905620 biolink:NamedThing negative regulation of alpha-(1->3)-fucosyltransferase activity Any process that stops, prevents or reduces the frequency, rate or extent of alpha-(1->3)-fucosyltransferase activity. got7fsn_ti down-regulation of alpha-1,3-fucosyltransferase activity|negative regulation of alpha(1,3)-fucosyltransferase activity|negative regulation of alpha-(1,3)-fucosyltransferase activity|inhibition of alpha(1,3)-fucosyltransferase activity|down regulation of alpha-(1,3)-fucosyltransferase activity|down regulation of alpha-(1->3)-fucosyltransferase activity|down regulation of alpha(1,3)-fucosyltransferase activity|inhibition of alpha-(1->3)-fucosyltransferase activity|inhibition of alpha-1,3-fucosyltransferase activity|down-regulation of alpha-(1,3)-fucosyltransferase activity|down regulation of alpha-1,3-fucosyltransferase activity|down-regulation of alpha(1,3)-fucosyltransferase activity|downregulation of alpha-(1->3)-fucosyltransferase activity|downregulation of alpha-1,3-fucosyltransferase activity|inhibition of alpha-(1,3)-fucosyltransferase activity|down-regulation of alpha-(1->3)-fucosyltransferase activity|negative regulation of alpha-1,3-fucosyltransferase activity|downregulation of alpha(1,3)-fucosyltransferase activity|downregulation of alpha-(1,3)-fucosyltransferase activity rz 2016-10-28T14:39:45Z biological_process owl:Class
GO:0001931 biolink:NamedThing uropod A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively. got7fsn_ti uropodium|retractile pole|distal pole complex cellular_component owl:Class
GO:1901040 biolink:NamedThing negative regulation of peptide antigen transport Any process that stops, prevents or reduces the frequency, rate or extent of peptide antigen transport. got7fsn_ti inhibition of peptide antigen transport|downregulation of peptide antigen transport|down regulation of peptide antigen transport|down-regulation of peptide antigen transport bf 2012-06-22T04:08:18Z biological_process owl:Class
GO:1904718 biolink:NamedThing negative regulation of AMPA glutamate receptor clustering Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor clustering. got7fsn_ti inhibition of AMPA glutamate receptor clustering|down regulation of AMPA glutamate receptor clustering|inhibition of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|down-regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|negative regulation of AMPA receptor clustering|downregulation of AMPA glutamate receptor clustering|downregulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|inhibition of AMPA receptor clustering|negative regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|downregulation of AMPA receptor clustering|down-regulation of AMPA receptor clustering|down regulation of AMPA receptor clustering|down regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering|down-regulation of AMPA glutamate receptor clustering hjd 2015-10-07T19:32:28Z biological_process owl:Class
GO:0072107 biolink:NamedThing positive regulation of ureteric bud formation Any process that increases the rate or extent of the developmental process pertaining to the initial formation of the ureteric bud from the Wolffian duct. got7fsn_ti mah 2010-02-12T02:37:28Z biological_process owl:Class
GO:0002631 biolink:NamedThing regulation of granuloma formation Any process that modulates the frequency, rate, or extent of granuloma formation. got7fsn_ti biological_process owl:Class
GO:0050544 biolink:NamedThing arachidonic acid binding Binding to arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. got7fsn_ti arachidonate binding molecular_function owl:Class
GO:0015759 biolink:NamedThing beta-glucoside transport The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration. got7fsn_ti biological_process owl:Class
GO:0015545 biolink:NamedThing bicyclomycin transmembrane transporter activity Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive. got7fsn_ti bicyclomycin transporter activity|bicyclomycin/sulfathiazole:hydrogen antiporter activity molecular_function owl:Class
GO:0015905 biolink:NamedThing bicyclomycin transmembrane transport The directed movement of bicyclomycin across a lipid bilayer, from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive. got7fsn_ti bicyclomycin transport biological_process owl:Class
GO:2000373 biolink:NamedThing positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity. got7fsn_ti positive regulation of DNA topoisomerase IV activity|positive regulation of DNA topoisomerase (ATP-hydrolysing)|positive regulation of deoxyribonucleate topoisomerase|positive regulation of topoisomerase II|positive regulation of DNA topoisomerase II|positive regulation of type II DNA topoisomerase activity|positive regulation of DNA topoisomerase type II activity|positive regulation of topoisomerase|positive regulation of deoxyribonucleic topoisomerase activity mah 2011-02-09T02:35:43Z biological_process owl:Class
GO:0042220 biolink:NamedThing response to cocaine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. got7fsn_ti biological_process owl:Class
GO:1990862 biolink:NamedThing nuclear membrane complex Bqt3-Bqt4 A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4. got7fsn_ti al 2015-09-25T12:14:28Z cellular_component owl:Class
GO:0005639 biolink:NamedThing integral component of nuclear inner membrane The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to nuclear inner membrane cellular_component owl:Class
GO:1903384 biolink:NamedThing negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of a hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway. got7fsn_ti inhibition of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|negative regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway|negative regulation of neuron apoptosis in response to hydrogen peroxide|protection against hydrogen peroxide-induced neuron apoptosis|down regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway|downregulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|negative regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|down-regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|down regulation of neuron apoptosis in response to hydrogen peroxide|down-regulation of neuron apoptosis in response to hydrogen peroxide|protection against H2O2-induced neuron apoptosis|negative regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|downregulation of H2O2-induced neuron intrinsic apoptotic signaling pathway|down-regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|inhibition of neuron apoptosis in response to hydrogen peroxide|inhibition of neuron intrinsic apoptotic signaling pathway in response to H2O2|downregulation of neuron apoptosis in response to hydrogen peroxide|downregulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|down regulation of neuron intrinsic apoptotic signaling pathway in response to H2O2|down regulation of neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide|inhibition of H2O2-induced neuron intrinsic apoptotic signaling pathway|down-regulation of H2O2-induced neuron intrinsic apoptotic signaling pathway bf 2014-08-27T08:50:45Z biological_process owl:Class
GO:0045693 biolink:NamedThing positive regulation of embryo sac central cell differentiation Any process that activates or increases the frequency, rate or extent of embryo sac central cell differentiation. got7fsn_ti positive regulation of female gametophyte central cell differentiation|activation of female gametophyte central cell differentiation|up regulation of female gametophyte central cell differentiation|stimulation of female gametophyte central cell differentiation|up-regulation of female gametophyte central cell differentiation|upregulation of female gametophyte central cell differentiation biological_process owl:Class
GO:0051958 biolink:NamedThing methotrexate transport The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase. got7fsn_ti biological_process owl:Class
GO:1901477 biolink:NamedThing benomyl transmembrane transport The directed movement of benomyl across a membrane. got7fsn_ti benomyl membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. tb 2012-10-04T23:11:36Z biological_process owl:Class
GO:0090173 biolink:NamedThing regulation of synaptonemal complex assembly Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed. got7fsn_ti tb 2009-12-11T11:40:36Z biological_process owl:Class
GO:1900264 biolink:NamedThing positive regulation of DNA-directed DNA polymerase activity Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity. got7fsn_ti up regulation of iota DNA polymerase activity|upregulation of zeta DNA polymerase activity|activation of DNA polymerase gamma|upregulation of lambda DNA polymerase activity|positive regulation of deoxyribonucleic duplicase activity|upregulation of deoxyribonucleic duplicase activity|up-regulation of DNA-directed DNA polymerase activity|up-regulation of eta DNA polymerase activity|positive regulation of DNA polymerase gamma|upregulation of Tca DNA polymerase|positive regulation of DNA polymerase beta|up regulation of DNA polymerase III|upregulation of kappa DNA polymerase activity|positive regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|up-regulation of DNA replicase activity|activation of beta DNA polymerase activity|activation of sigma DNA polymerase activity|activation of Taq Pol I|up-regulation of sigma DNA polymerase activity|up regulation of DNA duplicase activity|upregulation of sigma DNA polymerase activity|positive regulation of DNA duplicase activity|activation of eta DNA polymerase activity|activation of gamma DNA-directed DNA polymerase activity|up-regulation of zeta DNA polymerase activity|up regulation of deoxyribonucleic polymerase I|activation of DNA polymerase III|upregulation of Taq DNA polymerase|up-regulation of Taq DNA polymerase|positive regulation of Taq Pol I|up-regulation of epsilon DNA polymerase activity|up-regulation of deoxyribonucleic duplicase activity|upregulation of DNA polymerase alpha|activation of DNA polymerase alpha|activation of DNA polymerase V activity|upregulation of duplicase|activation of deoxyribonucleic polymerase I|positive regulation of gamma DNA-directed DNA polymerase activity|activation of DNA-directed DNA polymerase activity|upregulation of DNA polymerase III|positive regulation of Tca DNA polymerase|activation of DNA duplicase activity|upregulation of DNA-dependent DNA polymerase activity|up regulation of kappa DNA polymerase activity|up-regulation of gamma DNA-directed DNA polymerase activity|positive regulation of DNA nucleotidyltransferase (DNA-directed) activity|upregulation of alpha DNA polymerase activity|positive regulation of iota DNA polymerase activity|up regulation of deoxyribonucleic acid duplicase activity|up regulation of theta DNA polymerase activity|up regulation of DNA polymerase beta|activation of DNA polymerase II|upregulation of sequenase|upregulation of delta DNA polymerase activity|positive regulation of zeta DNA polymerase activity|activation of nu DNA polymerase activity|upregulation of DNA nucleotidyltransferase (DNA-directed) activity|positive regulation of duplicase|upregulation of DNA polymerase beta|up-regulation of alpha DNA polymerase activity|activation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|up-regulation of Tca DNA polymerase|up regulation of beta DNA polymerase activity|up-regulation of DNA polymerase alpha|positive regulation of sequenase|activation of iota DNA polymerase activity|positive regulation of mu DNA polymerase activity|upregulation of Klenow fragment|up regulation of Klenow fragment|up-regulation of DNA-dependent DNA polymerase activity|up regulation of mu DNA polymerase activity|upregulation of DNA polymerase gamma|positive regulation of theta DNA polymerase activity|up-regulation of DNA polymerase gamma|up-regulation of DNA polymerase II|upregulation of DNA-directed DNA polymerase activity|upregulation of DNA polymerase V activity|up-regulation of kappa DNA polymerase activity|upregulation of theta DNA polymerase activity|activation of delta DNA polymerase activity|up regulation of DNA polymerase I|activation of Klenow fragment|positive regulation of Taq DNA polymerase|up-regulation of delta DNA polymerase activity|up regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|up regulation of DNA polymerase II|activation of duplicase|upregulation of gamma DNA-directed DNA polymerase activity|positive regulation of delta DNA polymerase activity|up-regulation of DNA polymerase beta|up regulation of zeta DNA polymerase activity|activation of DNA polymerase beta|up regulation of DNA polymerase V activity|positive regulation of nu DNA polymerase activity|upregulation of deoxyribonucleic acid duplicase activity|positive regulation of lambda DNA polymerase activity|up-regulation of beta DNA polymerase activity|up regulation of alpha DNA polymerase activity|upregulation of epsilon DNA polymerase activity|activation of kappa DNA polymerase activity|upregulation of deoxyribonucleic polymerase I|up regulation of DNA-directed DNA polymerase activity|up regulation of gamma DNA-directed DNA polymerase activity|up regulation of lambda DNA polymerase activity|up regulation of eta DNA polymerase activity|up regulation of DNA replicase activity|up regulation of Taq DNA polymerase|up-regulation of DNA polymerase V activity|activation of zeta DNA polymerase activity|positive regulation of epsilon DNA polymerase activity|upregulation of mu DNA polymerase activity|upregulation of DNA polymerase I|up regulation of epsilon DNA polymerase activity|activation of sequenase|activation of alpha DNA polymerase activity|positive regulation of beta DNA polymerase activity|up-regulation of theta DNA polymerase activity|positive regulation of DNA polymerase III|activation of Taq DNA polymerase|up-regulation of deoxyribonucleic polymerase I|up regulation of deoxyribonucleic duplicase activity|up regulation of delta DNA polymerase activity|positive regulation of deoxyribonucleic polymerase I|upregulation of DNA replicase activity|activation of epsilon DNA polymerase activity|up-regulation of duplicase|upregulation of eta DNA polymerase activity|positive regulation of alpha DNA polymerase activity|up regulation of DNA-dependent DNA polymerase activity|positive regulation of eta DNA polymerase activity|activation of deoxyribonucleic duplicase activity|up regulation of DNA nucleotidyltransferase (DNA-directed) activity|positive regulation of DNA polymerase II|activation of deoxyribonucleic acid duplicase activity|up regulation of DNA polymerase alpha|up-regulation of mu DNA polymerase activity|up-regulation of deoxyribonucleic acid duplicase activity|positive regulation of DNA polymerase V activity|activation of DNA nucleotidyltransferase (DNA-directed) activity|upregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|up-regulation of sequenase|positive regulation of DNA polymerase I|up regulation of Taq Pol I|positive regulation of DNA polymerase alpha|upregulation of DNA polymerase II|up-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity|activation of theta DNA polymerase activity|positive regulation of Klenow fragment|upregulation of beta DNA polymerase activity|up-regulation of Klenow fragment|up-regulation of nu DNA polymerase activity|activation of lambda DNA polymerase activity|upregulation of Taq Pol I|up regulation of DNA polymerase gamma|up-regulation of lambda DNA polymerase activity|up regulation of sequenase|up regulation of Tca DNA polymerase|activation of DNA polymerase I|upregulation of iota DNA polymerase activity|up regulation of nu DNA polymerase activity|positive regulation of DNA replicase activity|up-regulation of DNA polymerase I|activation of mu DNA polymerase activity|up regulation of duplicase|up-regulation of DNA nucleotidyltransferase (DNA-directed) activity|up-regulation of DNA duplicase activity|up-regulation of DNA polymerase III|up regulation of sigma DNA polymerase activity|activation of DNA replicase activity|up-regulation of iota DNA polymerase activity|positive regulation of kappa DNA polymerase activity|positive regulation of deoxyribonucleic acid duplicase activity|up-regulation of Taq Pol I|activation of DNA-dependent DNA polymerase activity|positive regulation of DNA-dependent DNA polymerase activity|upregulation of DNA duplicase activity|upregulation of nu DNA polymerase activity|positive regulation of sigma DNA polymerase activity|activation of Tca DNA polymerase tb 2012-04-03T11:07:27Z biological_process owl:Class
GO:0015876 biolink:NamedThing acetyl-CoA transport The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis. got7fsn_ti biological_process owl:Class
GO:0042931 biolink:NamedThing enterobactin transmembrane transporter activity Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine from one side of a membrane to the other. got7fsn_ti enterobactin transporter activity|enterochelin transporter activity molecular_function owl:Class
GO:0042669 biolink:NamedThing regulation of inner ear auditory receptor cell fate specification Any process that mediates the specification of a cell into an auditory hair cell. got7fsn_ti regulation of inner ear auditory receptor cell fate specification|regulation of auditory hair cell fate specification biological_process owl:Class
GO:1904302 biolink:NamedThing negative regulation of maternal process involved in parturition Any process that stops, prevents or reduces the frequency, rate or extent of maternal process involved in parturition. got7fsn_ti down regulation of maternal process involved in parturition|inhibition of maternal process involved in parturition|downregulation of maternal process involved in parturition|down-regulation of maternal process involved in parturition sl 2015-06-09T23:01:38Z biological_process owl:Class
GO:0015797 biolink:NamedThing mannitol transport The directed movement of mannitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group. got7fsn_ti biological_process owl:Class
GO:0019991 biolink:NamedThing septate junction assembly The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space. got7fsn_ti biological_process owl:Class
GO:0060667 biolink:NamedThing branch elongation involved in salivary gland morphogenesis The differential growth of the salivary branches along their axis, resulting in the growth of a branch. got7fsn_ti dph 2009-06-01T09:42:13Z biological_process owl:Class
GO:0015204 biolink:NamedThing urea transmembrane transporter activity Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2. got7fsn_ti urea transporter activity GO:0015287 RHEA:32799|Reactome:R-HSA-444126 molecular_function owl:Class
GO:0061097 biolink:NamedThing regulation of protein tyrosine kinase activity Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity. got7fsn_ti dph 2010-04-26T02:34:53Z biological_process owl:Class
GO:0032820 biolink:NamedThing regulation of natural killer cell proliferation involved in immune response Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response. got7fsn_ti regulation of natural killer cell proliferation during immune response|regulation of NK cell proliferation during immune response biological_process owl:Class
GO:0015685 biolink:NamedThing ferric-enterobactin import into cell A process in which ferric-enterobactin, the iron-bound form of the siderophore enterobactin, is transported into the cell by specific cell surface receptors. got7fsn_ti ferric-enterobactin transport biological_process owl:Class
SO:0000276 biolink:NamedThing got7fsn_ti owl:Class
GO:0014904 biolink:NamedThing myotube cell development The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. got7fsn_ti biological_process owl:Class
GO:0014011 biolink:NamedThing Schwann cell proliferation involved in axon regeneration The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system. got7fsn_ti biological_process owl:Class
GO:1901252 biolink:NamedThing regulation of intracellular transport of viral material Any process that modulates the frequency, rate or extent of egress of virus within host cell. got7fsn_ti regulation of movement of virus within host cell|regulation of egress of virus within host cell|regulation of viral egress ss 2012-08-09T05:45:25Z biological_process owl:Class
GO:0120143 biolink:NamedThing negative regulation of ecdysone receptor-mediated signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of any ecdysone receptor-mediated signaling pathway. got7fsn_ti krc 2018-03-22T17:28:29Z biological_process owl:Class
GO:0150022 biolink:NamedThing apical dendrite development The process whose specific outcome is the progression of an apical dendrite over time, from its formation to the mature structure. got7fsn_ti bc 2017-12-22T11:52:40Z biological_process owl:Class
GO:0034202 biolink:NamedThing glycolipid floppase activity Catalysis of the movement of a glycolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. got7fsn_ti glycolipid-translocating activity|glycolipid floppase activity (cytosolic to exoplasmic leaftlet)|ATPase-coupled intramembrane glycolipid transporter activity|ATP-dependent intramembrane glycolipid transporter activity Reactome:R-HSA-446212|Reactome:R-HSA-4570573 molecular_function owl:Class
GO:0034203 biolink:NamedThing glycolipid translocation The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer. got7fsn_ti biological_process owl:Class
GO:1904379 biolink:NamedThing protein localization to cytosolic proteasome complex involved in ERAD pathway Any protein localization to cytosolic proteasome complex that is involved in ERAD pathway. Following their retrotranslocation out of the endoplasmic reticulum, protein substrates must be shuttled to the cytosolic proteasome for degradation. got7fsn_ti protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation|protein localisation to cytosolic proteasome complex involved in ER-associated degradation pathway|protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway|protein localization in cytosolic proteasome complex involved in ER-associated degradation pathway|protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation|protein localisation in cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation|protein localization in cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway|protein localization to cytosolic proteasome complex involved in ER-associated degradation pathway|protein localization in cytosolic proteasome complex involved in ERAD pathway|protein localisation to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway|protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated degradation|protein localisation to cytosolic proteasome complex involved in ERAD pathway|protein localisation in cytosolic proteasome complex involved in ER-associated degradation pathway|protein localisation in cytosolic proteasome complex involved in ERAD pathway|protein localization to cytosolic proteasome complex involved in endoplasmic reticulum-associated protein degradation pathway bf 2015-06-23T09:30:07Z biological_process owl:Class
GO:1902813 biolink:NamedThing negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry Any process that stops, prevents or reduces the frequency, rate or extent of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry. got7fsn_ti down-regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|down regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|down regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|downregulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|downregulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|inhibition of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|inhibition of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|down-regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|inhibition of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|negative regulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|down-regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination|downregulation of BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry|down regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry|negative regulation of BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination mr 2014-03-26T21:18:50Z biological_process owl:Class
GO:0032079 biolink:NamedThing positive regulation of endodeoxyribonuclease activity Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. got7fsn_ti up-regulation of endodeoxyribonuclease activity|activation of endodeoxyribonuclease activity|upregulation of endodeoxyribonuclease activity|stimulation of endodeoxyribonuclease activity|up regulation of endodeoxyribonuclease activity|endodeoxyribonuclease activator biological_process owl:Class
GO:0098522 biolink:NamedThing neuromuscular junction of skeletal muscle fiber A neuromuscular junction in which the target muscle cell is a skeletal muscle fiber. got7fsn_ti In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. dos 2013-10-14T12:04:32Z cellular_component owl:Class
GO:1905936 biolink:NamedThing regulation of germ cell proliferation Any process that modulates the frequency, rate or extent of germ cell proliferation. got7fsn_ti hbye 2017-02-09T14:51:31Z biological_process owl:Class
GO:0046623 biolink:NamedThing sphingolipid floppase activity Catalysis of the movement of a sphingolipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. got7fsn_ti sphingolipid-translocating ATPase activity|sphingolipid flippase activity|sphingolipid floppase activity (cytosolic to exoplasmic leaftlet) molecular_function owl:Class
GO:0099039 biolink:NamedThing sphingolipid translocation The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. got7fsn_ti biological_process owl:Class
CHEBI:15355 biolink:NamedThing got7fsn_ti owl:Class
GO:1904836 biolink:NamedThing facioacoustic ganglion morphogenesis The developmental process by which an acoustico-facial VII-VIII ganglion complex is generated and organized. got7fsn_ti facio-acoustic ganglion complex VII-VIII morphogenesis|facio-acoustic ganglion complex morphogenesis|facio-acoustic ganglion morphogenesis|acousticofacial ganglion morphogenesis|facio-acoustic VII-VIII ganglion complex morphogenesis|acoustico-facial VII-VIII ganglion complex morphogenesis bf 2015-12-01T17:02:06Z biological_process owl:Class
GO:1903375 biolink:NamedThing facioacoustic ganglion development The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure. got7fsn_ti facio-acoustic VII-VIII ganglion complex development|facio-acoustic ganglion development|acoustico-facial VII-VIII ganglion complex development|facio-acoustic ganglion complex VII-VIII development|acousticofacial ganglion development bf 2014-08-26T12:40:36Z biological_process owl:Class
GO:1905623 biolink:NamedThing positive regulation of leaf development Any process that activates or increases the frequency, rate or extent of leaf development. got7fsn_ti up-regulation of leaf development|up regulation of leaf development|activation of leaf development|upregulation of leaf development pga 2016-10-28T15:30:04Z biological_process owl:Class
GO:0009359 biolink:NamedThing type II site-specific deoxyribonuclease complex A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell. got7fsn_ti type II restriction enzyme complex cellular_component owl:Class
GO:2000748 biolink:NamedThing positive regulation of defecation rhythm Any process that activates or increases the frequency, rate or extent of defecation rhythm. got7fsn_ti positive regulation of defecation behavior|positive regulation of defecation cycle|positive regulation of DMP|positive regulation of defecation motor program bf 2011-06-15T03:23:13Z biological_process owl:Class
GO:0010950 biolink:NamedThing positive regulation of endopeptidase activity Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. got7fsn_ti tb 2009-04-27T11:45:39Z biological_process owl:Class
GO:0140194 biolink:NamedThing negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in some heart process. got7fsn_ti pg 2018-02-15T19:13:02Z biological_process owl:Class
GO:0002789 biolink:NamedThing negative regulation of antifungal peptide production Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production. got7fsn_ti downregulation of antifungal peptide production|down-regulation of antifungal peptide production|inhibition of antifungal peptide production|down regulation of antifungal peptide production biological_process owl:Class
GO:2000557 biolink:NamedThing regulation of immunoglobulin production in mucosal tissue Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue. got7fsn_ti regulation of antibody production in mucosal tissue ebc 2011-04-03T07:52:09Z biological_process owl:Class
GO:2000808 biolink:NamedThing negative regulation of synaptic vesicle clustering Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle clustering. got7fsn_ti pr 2011-07-06T09:50:34Z biological_process owl:Class
GO:1905781 biolink:NamedThing negative regulation of phosphatidylserine exposure on apoptotic cell surface Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylserine exposure on apoptotic cell surface. got7fsn_ti inhibition of phosphatidylserine exposure on apoptotic cell surface|down-regulation of phosphatidylserine exposure on apoptotic cell surface|down-regulation of externalization of phosphatidylserine|down regulation of externalization of phosphatidylserine|down regulation of phosphatidylserine exposure on apoptotic cell surface|inhibition of externalization of phosphatidylserine|downregulation of externalization of phosphatidylserine|negative regulation of externalization of phosphatidylserine|downregulation of phosphatidylserine exposure on apoptotic cell surface kmv 2017-01-04T15:19:14Z biological_process owl:Class
GO:2000650 biolink:NamedThing negative regulation of sodium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity. got7fsn_ti negative regulation of sodium transporter activity yaf 2011-04-28T08:42:57Z biological_process owl:Class
GO:0043879 biolink:NamedThing glycolate transmembrane transporter activity Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA). got7fsn_ti glycolate permease|glcA|glycolic acid transmembrane transporter activity|hydroxyacetic acid transmembrane transporter activity RHEA:29447 molecular_function owl:Class
GO:0097339 biolink:NamedThing glycolate transmembrane transport The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid). got7fsn_ti glycolate membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. pr 2012-06-12T05:12:35Z biological_process owl:Class
GO:0016507 biolink:NamedThing mitochondrial fatty acid beta-oxidation multienzyme complex A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. got7fsn_ti trifunctional enzyme|fatty acid beta-oxidation multienzyme complex cellular_component owl:Class
PATO:0002487 biolink:NamedThing got7fsn_ti owl:Class
GO:0031304 biolink:NamedThing intrinsic component of mitochondrial inner membrane The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. got7fsn_ti intrinsic to mitochondrial inner membrane cellular_component owl:Class
GO:1901399 biolink:NamedThing negative regulation of transforming growth factor beta3 activation Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta3 activation. got7fsn_ti down-regulation of TGF-beta 3 activation|negative regulation of TGFbeta 3 activation|negative regulation of TGF-beta 3 activation|down regulation of TGFB3 activation|down regulation of TGFbeta 3 activation|down-regulation of TGFB3 activation|down-regulation of TGFbeta 3 activation|down regulation of transforming growth factor beta3 activation|inhibition of TGFB3 activation|inhibition of transforming growth factor beta3 activation|down-regulation of transforming growth factor beta3 activation|negative regulation of TGFB3 activation|inhibition of TGFbeta 3 activation|downregulation of TGFB3 activation|inhibition of TGF-beta 3 activation|downregulation of TGFbeta 3 activation|downregulation of TGF-beta 3 activation|downregulation of transforming growth factor beta3 activation|down regulation of TGF-beta 3 activation bf 2012-10-01T10:50:32Z biological_process owl:Class
UBERON:0000059 biolink:NamedThing got7fsn_ti owl:Class
GO:0042929 biolink:NamedThing ferrichrome transmembrane transporter activity Enables the directed movement of a ferrichrome from one side of a membrane to the other. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. got7fsn_ti ferrichrome transporter activity molecular_function owl:Class
GO:0042928 biolink:NamedThing ferrichrome import into cell A process in which ferrichrome is transported into the cell by specific cell surface receptors. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine. got7fsn_ti ferrichrome transport biological_process owl:Class
GO:0070418 biolink:NamedThing DNA-dependent protein kinase complex A protein complex that is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and the DNA end-binding heterodimer Ku. got7fsn_ti DNA-dependent protein kinase, DNA-end-binding complex|DNA-PK-Ku antigen complex|DNA-PK complex cellular_component owl:Class
GO:0086080 biolink:NamedThing protein binding involved in heterotypic cell-cell adhesion Binding to a protein or protein complex contributing to the adhesion of two different types of cells. got7fsn_ti dph 2011-11-22T10:53:52Z molecular_function owl:Class
GO:1904029 biolink:NamedThing regulation of cyclin-dependent protein kinase activity Any process that modulates the frequency, rate or extent of cyclin-dependent protein kinase activity. got7fsn_ti als 2015-03-13T15:43:38Z biological_process owl:Class
GO:0032413 biolink:NamedThing negative regulation of ion transmembrane transporter activity Any process that stops or reduces the activity of an ion transporter. got7fsn_ti downregulation of ion transporter activity|down-regulation of ion transporter activity|down regulation of ion transporter activity|negative regulation of ion transporter activity|inhibition of ion transporter activity biological_process owl:Class
GO:0000923 biolink:NamedThing equatorial microtubule organizing center A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis. got7fsn_ti EMTOC|equatorial microtubule organising centre cellular_component owl:Class
GO:0032400 biolink:NamedThing melanosome localization Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell. got7fsn_ti melanosome localisation biological_process owl:Class
GO:0045624 biolink:NamedThing positive regulation of T-helper cell differentiation Any process that activates or increases the frequency, rate or extent of T-helper cell differentiation. got7fsn_ti up regulation of T-helper cell differentiation|stimulation of T-helper cell differentiation|upregulation of T-helper cell differentiation|activation of T-helper cell differentiation|up-regulation of T-helper cell differentiation|positive regulation of T-helper cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:2000175 biolink:NamedThing negative regulation of pro-T cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation. got7fsn_ti negative regulation of pro-T lymphocyte differentiation mah 2010-10-11T10:24:33Z biological_process owl:Class
GO:0015133 biolink:NamedThing uronic acid transmembrane transporter activity Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose. got7fsn_ti molecular_function owl:Class
GO:0015735 biolink:NamedThing uronic acid transmembrane transport The process in which uronic acid is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti uronic acid transport biological_process owl:Class
GO:0071378 biolink:NamedThing cellular response to growth hormone stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth. got7fsn_ti mah 2009-12-11T03:25:17Z biological_process owl:Class
GO:2000329 biolink:NamedThing negative regulation of T-helper 17 cell lineage commitment Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment. got7fsn_ti negative regulation of Th17 fate commitment|negative regulation of T-helper 17 cell fate commitment|negative regulation of Th17 cell lineage commitment mah 2011-01-19T09:31:53Z biological_process owl:Class
GO:0070953 biolink:NamedThing regulation of neutrophil mediated killing of fungus Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a fungal cell, the directed killing of a fungal cell by a neutrophil. got7fsn_ti mah 2009-10-01T02:14:36Z biological_process owl:Class
GO:0015663 biolink:NamedThing nicotinamide mononucleotide transmembrane transporter activity Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP. got7fsn_ti nicotinamide mononucleotide permease activity|nicotinamide ribonucleotide transmembrane transporter activity GO:0015664 molecular_function owl:Class
GO:0035353 biolink:NamedThing nicotinamide mononucleotide transmembrane transport The process in which nicotinamide mononucleotide is transported across a membrane. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP. got7fsn_ti nicotinamide mononucleotide membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-03-04T03:46:55Z biological_process owl:Class
GO:0042556 biolink:NamedThing eukaryotic elongation factor-2 kinase regulator activity Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase. got7fsn_ti eEF-2 kinase regulator molecular_function owl:Class
GO:0030505 biolink:NamedThing inorganic diphosphate transport The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti inorganic pyrophosphate transport biological_process owl:Class
GO:0010572 biolink:NamedThing positive regulation of platelet activation Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. got7fsn_ti biological_process owl:Class
NCBITaxon:Union_0000022 biolink:NamedThing got7fsn_ti owl:Class
GO:0042880 biolink:NamedThing D-glucuronate transmembrane transporter activity Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of a membrane to the other. got7fsn_ti molecular_function owl:Class
GO:0042874 biolink:NamedThing D-glucuronate transmembrane transport The process in which D-glucuronate, the D-enantiomer of glucuronate, is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti D-glucuronate transport biological_process owl:Class
GO:1900106 biolink:NamedThing positive regulation of hyaluranon cable assembly Any process that activates or increases the frequency, rate or extent of hyaluranon cable assembly. got7fsn_ti positive regulation of HA cable assembly|upregulation of hyaluranon cable assembly|up regulation of hyaluranon cable assembly|activation of hyaluranon cable assembly|up-regulation of hyaluranon cable assembly|up-regulation of HA cable assembly|upregulation of HA cable assembly|activation of HA cable assembly|up regulation of HA cable assembly yaf 2012-02-16T01:00:54Z biological_process owl:Class
GO:1902846 biolink:NamedThing positive regulation of mitotic spindle elongation Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation. got7fsn_ti up-regulation of spindle elongation during mitosis|activation of mitotic spindle elongation|up regulation of mitotic spindle elongation|upregulation of mitotic spindle elongation|up regulation of spindle elongation during mitosis|activation of spindle elongation during mitosis|upregulation of spindle elongation during mitosis|positive regulation of spindle elongation during mitosis|up-regulation of mitotic spindle elongation vw 2014-04-02T08:43:34Z biological_process owl:Class
GO:0061089 biolink:NamedThing negative regulation of sequestering of zinc ion Any process that decreases the rate, frequency, or extent of sequestering of zinc ion. Sequestering of zinc ion is the process of binding or confining zinc ions such that they are separated from other components of a biological system. got7fsn_ti dph 2010-04-26T01:38:53Z biological_process owl:Class
GO:0045623 biolink:NamedThing negative regulation of T-helper cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper cell differentiation. got7fsn_ti negative regulation of T-helper cell development|downregulation of T-helper cell differentiation|inhibition of T-helper cell differentiation|down-regulation of T-helper cell differentiation|down regulation of T-helper cell differentiation Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0045313 biolink:NamedThing rhabdomere membrane biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane. got7fsn_ti biological_process owl:Class
GO:0071071 biolink:NamedThing regulation of phospholipid biosynthetic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. got7fsn_ti regulation of phospholipid anabolism|regulation of phospholipid biosynthesis|regulation of phospholipid synthesis|regulation of phospholipid formation mah 2009-11-04T03:05:11Z biological_process owl:Class
GO:0009843 biolink:NamedThing cyanelle thylakoid A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria. got7fsn_ti cellular_component owl:Class
GO:0062199 biolink:NamedThing chromosome, centromeric inner repeat region The portion of the centromeric region of a chromosome that contains the inner inverted repeat region of a modular centromere and part of the central core surrounding a non-conserved central region. This region is adjacent to the central core, on each chromosome arm. got7fsn_ti chromosome, centric outer repeat region dph 2019-12-11T20:38:14Z cellular_component owl:Class
GO:0043951 biolink:NamedThing negative regulation of cAMP-mediated signaling Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. got7fsn_ti negative regulation of cAMP-mediated signalling biological_process owl:Class
GO:0009328 biolink:NamedThing phenylalanine-tRNA ligase complex An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe). got7fsn_ti cellular_component owl:Class
GO:2000556 biolink:NamedThing positive regulation of T-helper 1 cell cytokine production Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production. got7fsn_ti positive regulation of Th1 cell cytokine production ebc 2011-04-03T07:35:56Z biological_process owl:Class
GO:0015185 biolink:NamedThing gamma-aminobutyric acid transmembrane transporter activity Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). got7fsn_ti 4-aminobutyrate transporter activity|betaine/GABA:sodium symporter activity|GABA transporter activity|4-aminobutanoate transporter activity molecular_function owl:Class
GO:0015812 biolink:NamedThing gamma-aminobutyric acid transport The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti 4-aminobutanoate transport|GABA transport|4-aminobutyrate transport See also the biological process term 'neurotransmitter transport ; GO:0006836'. biological_process owl:Class
GO:1902234 biolink:NamedThing positive regulation of positive thymic T cell selection Any process that activates or increases the frequency, rate or extent of positive thymic T cell selection. got7fsn_ti activation of positive thymic T-cell selection|upregulation of positive thymic T-lymphocyte selection|up regulation of positive thymic T-cell selection|positive regulation of positive thymic T-cell selection|activation of positive thymic T cell selection|upregulation of positive thymic T-cell selection|positive regulation of positive thymic T-lymphocyte selection|up-regulation of positive thymic T-lymphocyte selection|activation of positive thymic T lymphocyte selection|up-regulation of positive thymic T cell selection|up regulation of positive thymic T lymphocyte selection|positive regulation of positive thymic T lymphocyte selection|up regulation of positive thymic T cell selection|up-regulation of positive thymic T-cell selection|up regulation of positive thymic T-lymphocyte selection|activation of positive thymic T-lymphocyte selection|up-regulation of positive thymic T lymphocyte selection|upregulation of positive thymic T cell selection|upregulation of positive thymic T lymphocyte selection lb 2013-06-14T11:19:20Z biological_process owl:Class
GO:1902748 biolink:NamedThing positive regulation of lens fiber cell differentiation Any process that activates or increases the frequency, rate or extent of lens fiber cell differentiation. got7fsn_ti activation of lens fiber cell differentiation|up-regulation of lens fibre cell differentiation|upregulation of lens fibre cell differentiation|up-regulation of lens fiber cell differentiation|up regulation of lens fiber cell differentiation|positive regulation of lens fibre cell differentiation|upregulation of lens fiber cell differentiation|activation of lens fibre cell differentiation|up regulation of lens fibre cell differentiation mr 2014-03-03T23:20:12Z biological_process owl:Class
GO:0042926 biolink:NamedThing 3-hydroxyphenylpropionic acid transmembrane transporter activity Enables the directed movement of 3-hydroxyphenylpropionic acid from one side of a membrane to the other. got7fsn_ti 3-(3-hydroxyphenyl)propionic acid transporter activity|3-hydroxyphenylpropionic acid transporter activity|m-hydroxyphenylpropionic acid transporter activity molecular_function owl:Class
GO:0042920 biolink:NamedThing 3-hydroxyphenylpropionic acid transmembrane transport The directed movement of 3-hydroxyphenylpropionic acid across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti 3-(3-hydroxyphenyl)propionic acid transport|3-hydroxyphenylpropionic acid transport|m-hydroxyphenylpropionic acid transport biological_process owl:Class
GO:1905598 biolink:NamedThing negative regulation of low-density lipoprotein receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of low-density lipoprotein receptor activity. got7fsn_ti inhibition of LDL receptor|negative regulation of LDLR activity|down regulation of LDLR activity|downregulation of LDLR activity|down-regulation of low-density lipoprotein receptor activity|inhibition of low-density lipoprotein receptor activity|negative regulation of LDL receptor|downregulation of low-density lipoprotein receptor activity|down regulation of LDL receptor|downregulation of LDL receptor|down regulation of low-density lipoprotein receptor activity|inhibition of LDLR activity|down-regulation of LDLR activity|down-regulation of LDL receptor nc 2016-10-26T11:53:34Z biological_process owl:Class
GO:0043380 biolink:NamedThing regulation of memory T cell differentiation Any process that modulates the frequency, rate, or extent of memory T cell differentiation. got7fsn_ti regulation of memory T-lymphocyte differentiation|regulation of memory T lymphocyte differentiation|regulation of memory T-cell differentiation|regulation of memory T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:1905618 biolink:NamedThing positive regulation of miRNA mediated inhibition of translation Any process that activates or increases the frequency, rate or extent of miRNA mediated inhibition of translation. got7fsn_ti activation of downregulation of translation involved in gene silencing by miRNA|up-regulation of down-regulation of translation involved in gene silencing by miRNA|up regulation of negative regulation of translation involved in gene silencing by microRNA|up regulation of miRNA mediated inhibition of translation|upregulation of downregulation of translation involved in gene silencing by miRNA|positive regulation of down-regulation of translation involved in gene silencing by miRNA|activation of down regulation of translation involved in gene silencing by miRNA|activation of down-regulation of translation involved in gene silencing by miRNA|activation of miRNA-mediated gene silencing, negative regulation of translation|upregulation of miRNA-mediated gene silencing, negative regulation of translation|upregulation of down-regulation of translation involved in gene silencing by miRNA|up regulation of downregulation of translation involved in gene silencing by miRNA|up regulation of gene silencing by miRNA, negative regulation of translation|positive regulation of negative regulation of translation involved in gene silencing by microRNA|up-regulation of miRNA mediated inhibition of translation|positive regulation of gene silencing by miRNA, negative regulation of translation|positive regulation of downregulation of translation involved in gene silencing by miRNA|up regulation of miRNA-mediated gene silencing, negative regulation of translation|positive regulation of inhibition of translation involved in gene silencing by miRNA|up-regulation of miRNA-mediated gene silencing, negative regulation of translation|upregulation of down regulation of translation involved in gene silencing by miRNA|up-regulation of inhibition of translation involved in gene silencing by miRNA|positive regulation of down regulation of translation involved in gene silencing by miRNA|up regulation of down-regulation of translation involved in gene silencing by miRNA|activation of gene silencing by miRNA, negative regulation of translation|upregulation of miRNA mediated inhibition of translation|upregulation of gene silencing by miRNA, negative regulation of translation|upregulation of inhibition of translation involved in gene silencing by miRNA|up-regulation of downregulation of translation involved in gene silencing by miRNA|up regulation of down regulation of translation involved in gene silencing by miRNA|upregulation of negative regulation of translation involved in gene silencing by microRNA|activation of inhibition of translation involved in gene silencing by miRNA|activation of negative regulation of translation involved in gene silencing by microRNA|up-regulation of gene silencing by miRNA, negative regulation of translation|up-regulation of down regulation of translation involved in gene silencing by miRNA|up regulation of inhibition of translation involved in gene silencing by miRNA|activation of miRNA mediated inhibition of translation|positive regulation of miRNA-mediated gene silencing, negative regulation of translation|up-regulation of negative regulation of translation involved in gene silencing by microRNA bc 2016-10-28T11:48:04Z biological_process owl:Class
GO:0045637 biolink:NamedThing regulation of myeloid cell differentiation Any process that modulates the frequency, rate or extent of myeloid cell differentiation. got7fsn_ti biological_process owl:Class
GO:0120137 biolink:NamedThing positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity Any process that activates or increases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. got7fsn_ti krc 2018-03-21T21:59:55Z biological_process owl:Class
GO:0051459 biolink:NamedThing regulation of corticotropin secretion Any process that modulates the frequency, rate or extent of the regulated release of corticotropic hormone from a cell. got7fsn_ti regulation of adrenotropin secretion|regulation of adrenotropin hormone secretion|regulation of adrenocorticotropic hormone secretion|regulation of ACTH secretion|regulation of adrenocorticotropin secretion|regulation of corticotropic hormone secretion biological_process owl:Class
GO:1903468 biolink:NamedThing positive regulation of DNA replication initiation Any process that activates or increases the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. got7fsn_ti up regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|up regulation of DNA replication initiation involved in mitotic DNA replication|up-regulation of DNA replication initiation involved in mitotic DNA replication|up-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|activation of DNA replication initiation involved in mitotic cell cycle DNA replication|positive regulation of DNA replication initiation involved in mitotic cell cycle DNA replication|upregulation of DNA replication initiation involved in mitotic cell cycle DNA replication|upregulation of DNA replication initiation involved in mitotic DNA replication|activation of DNA replication initiation involved in mitotic DNA replication vw 2014-09-23T13:39:06Z biological_process owl:Class
CL:0000218 biolink:NamedThing got7fsn_ti owl:Class
GO:0071073 biolink:NamedThing positive regulation of phospholipid biosynthetic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phospholipids. got7fsn_ti positive regulation of phospholipid synthesis|upregulation of phospholipid biosynthetic process|up regulation of phospholipid biosynthetic process|stimulation of phospholipid biosynthetic process|positive regulation of phospholipid biosynthesis|positive regulation of phospholipid formation|up-regulation of phospholipid biosynthetic process|activation of phospholipid biosynthetic process|positive regulation of phospholipid anabolism mah 2009-11-04T03:18:51Z biological_process owl:Class
GO:0009157 biolink:NamedThing deoxyribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar. got7fsn_ti deoxyribonucleoside monophosphate formation|deoxyribonucleoside monophosphate synthesis|deoxyribonucleoside monophosphate biosynthesis|deoxyribonucleoside monophosphate anabolism biological_process owl:Class
GO:0015127 biolink:NamedThing bilirubin transmembrane transporter activity Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile. got7fsn_ti Reactome:R-HSA-9661417|Reactome:R-HSA-5679031|Reactome:R-HSA-5679041 molecular_function owl:Class
GO:0015723 biolink:NamedThing bilirubin transport The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:1902943 biolink:NamedThing positive regulation of voltage-gated chloride channel activity Any process that activates or increases the frequency, rate or extent of voltage-gated chloride channel activity. got7fsn_ti activation of voltage-dependent chloride channel activity|activation of voltage-gated chloride channel activity|upregulation of voltage-gated chloride channel activity|up-regulation of voltage-gated chloride channel activity|up-regulation of voltage-dependent chloride channel activity|upregulation of voltage gated chloride channel activity|activation of voltage gated chloride channel activity|up regulation of voltage-dependent chloride channel activity|up-regulation of voltage gated chloride channel activity|positive regulation of voltage-dependent chloride channel activity|positive regulation of voltage gated chloride channel activity|up regulation of voltage-gated chloride channel activity|upregulation of voltage-dependent chloride channel activity|up regulation of voltage gated chloride channel activity als 2014-04-28T08:55:43Z biological_process owl:Class
GO:1902951 biolink:NamedThing negative regulation of dendritic spine maintenance Any process that stops, prevents or reduces the frequency, rate or extent of dendritic spine maintenance. got7fsn_ti down regulation of dendritic spine maintenance|down-regulation of dendritic spine maintenance|inhibition of dendritic spine maintenance|downregulation of dendritic spine maintenance sjp 2014-05-02T08:48:53Z biological_process owl:Class
GO:1904457 biolink:NamedThing positive regulation of neuronal action potential Any process that activates or increases the frequency, rate or extent of neuronal action potential. got7fsn_ti activation of generation of action potential|up regulation of neuronal action potential|up-regulation of generation of action potential|upregulation of generation of action potential|positive regulation of generation of action potential|up-regulation of neuronal action potential|activation of neuronal action potential|up regulation of generation of action potential|upregulation of neuronal action potential sl 2015-07-09T18:02:46Z biological_process owl:Class
GO:0031149 biolink:NamedThing sorocarp stalk cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum. got7fsn_ti stalk cell differentiation biological_process owl:Class
GO:1903954 biolink:NamedThing positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization. got7fsn_ti upregulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|positive regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|up-regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|upregulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|up-regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|up regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|activation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|up regulation of voltage-gated potassium channel activity involved in atrial cardiomyocyte action potential repolarization|activation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization nc 2015-02-24T10:32:24Z biological_process owl:Class
GO:1903979 biolink:NamedThing negative regulation of microglial cell activation Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation. got7fsn_ti down regulation of microglial cell activation|down-regulation of microglial cell activation|downregulation of microglial cell activation|inhibition of microglial cell activation nc 2015-03-02T15:17:39Z biological_process owl:Class
GO:0048633 biolink:NamedThing positive regulation of skeletal muscle tissue growth Any process that activates, maintains or increases the rate of skeletal muscle growth. got7fsn_ti upregulation of skeletal muscle growth|stimulation of skeletal muscle growth|activation of skeletal muscle growth|up-regulation of skeletal muscle growth|up regulation of skeletal muscle growth biological_process owl:Class
CHEBI:57856 biolink:NamedThing got7fsn_ti owl:Class
GO:0070962 biolink:NamedThing positive regulation of neutrophil mediated killing of bacterium Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil. got7fsn_ti up regulation of neutrophil mediated killing of bacterium|activation of neutrophil mediated killing of bacterium|stimulation of neutrophil mediated killing of bacterium|up-regulation of neutrophil mediated killing of bacterium|upregulation of neutrophil mediated killing of bacterium mah 2009-10-01T02:28:49Z biological_process owl:Class
GO:0003253 biolink:NamedThing cardiac neural crest cell migration involved in outflow tract morphogenesis The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract. got7fsn_ti dph 2009-10-13T02:14:16Z biological_process owl:Class
GO:0061309 biolink:NamedThing cardiac neural crest cell development involved in outflow tract morphogenesis The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract. got7fsn_ti dph 2010-09-23T09:08:37Z biological_process owl:Class
GO:0060015 biolink:NamedThing granulosa cell fate commitment The cell fate commitment of precursor cells that will become granulosa cells. got7fsn_ti biological_process owl:Class
GO:1904970 biolink:NamedThing brush border assembly The aggregation, arrangement and bonding together of adjacent microvilli through the formation of Ca(2+)-dependent adhesion links between them, forming a brush border. got7fsn_ti brush border formation tb 2016-02-17T00:58:30Z biological_process owl:Class
GO:0043382 biolink:NamedThing positive regulation of memory T cell differentiation Any process that activates or increases the frequency, rate or extent of memory T cell differentiation. got7fsn_ti upregulation of memory T cell differentiation|stimulation of memory T cell differentiation|up regulation of memory T cell differentiation|positive regulation of memory T-lymphocyte differentiation|up-regulation of memory T cell differentiation|positive regulation of memory T-cell differentiation|activation of memory T cell differentiation|positive regulation of memory T lymphocyte differentiation|positive regulation of memory T cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
OBO:OPL_0000076 biolink:NamedThing got7fsn_ti owl:Class
GO:0006780 biolink:NamedThing uroporphyrinogen III biosynthetic process The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. got7fsn_ti uroporphyrinogen III formation|uroporphyrinogen III anabolism|uroporphyrinogen III biosynthesis|uroporphyrinogen III synthesis biological_process owl:Class
GO:0070949 biolink:NamedThing regulation of neutrophil mediated killing of symbiont cell Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil. got7fsn_ti mah 2009-10-01T02:14:36Z biological_process owl:Class
GO:0150068 biolink:NamedThing positive regulation of tubulin deacetylase activity Any process that activates or increases the frequency, rate or extent of tubulin deacetylase activity. got7fsn_ti bc 2018-07-24T10:35:51Z biological_process owl:Class
GO:0019550 biolink:NamedThing glutamate catabolic process to aspartate The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate. got7fsn_ti glutamate degradation to aspartate|glutamate breakdown to aspartate MetaCyc:GLUTDEG-PWY biological_process owl:Class
GO:0060334 biolink:NamedThing regulation of interferon-gamma-mediated signaling pathway Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor. got7fsn_ti regulation of type II interferon-mediated signaling pathway|regulation of gamma-interferon-mediated signaling pathway|regulation of immune interferon signaling pathway|regulation of interferon-gamma-mediated signalling pathway|regulation of type II IFN-mediated signaling pathway biological_process owl:Class
GO:0060728 biolink:NamedThing negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway Any process that decreases the rate or frequency of coreceptor activity involved in epidermal growth factor receptor signaling pathway. got7fsn_ti negative regulation of coreceptor activity involved in epidermal growth factor receptor signalling pathway|negative regulation of Neu/ErbB-2 receptor activity dph 2009-06-12T01:32:38Z biological_process owl:Class
GO:0003134 biolink:NamedThing endodermal-mesodermal cell signaling involved in heart induction Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction. got7fsn_ti endodermal-mesodermal cell signalling involved in heart induction tb 2009-09-22T03:11:17Z biological_process owl:Class
GO:0015113 biolink:NamedThing nitrite transmembrane transporter activity Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other. got7fsn_ti nitrite/nitrate porter activity molecular_function owl:Class
GO:0015707 biolink:NamedThing nitrite transport The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0060278 biolink:NamedThing regulation of ovulation Any process that modulates the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary. got7fsn_ti biological_process owl:Class
GO:2000239 biolink:NamedThing negative regulation of tRNA export from nucleus Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus. got7fsn_ti negative regulation of tRNA export out of nucleus|negative regulation of tRNA-nucleus export|negative regulation of tRNA transport from nucleus to cytoplasm|negative regulation of tRNA export from cell nucleus mah 2010-11-10T12:39:36Z biological_process owl:Class
GO:0042648 biolink:NamedThing chloroplast chromosome A circular DNA molecule containing chloroplast encoded genes. got7fsn_ti cellular_component owl:Class
GO:0048092 biolink:NamedThing negative regulation of male pigmentation Any process that stops, prevents, or reduces the frequency, rate or extent of establishment of a pattern of pigment in males. got7fsn_ti down-regulation of male pigmentation|downregulation of male pigmentation|down regulation of male pigmentation|inhibition of male pigmentation biological_process owl:Class
GO:0071305 biolink:NamedThing cellular response to vitamin D Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. got7fsn_ti cellular response to cholecalciferol|cellular response to calciferol|cellular response to ergocalciferol mah 2009-12-10T04:35:37Z biological_process owl:Class
GO:0015779 biolink:NamedThing glucuronoside transport The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate. got7fsn_ti glucuronide transport biological_process owl:Class
GO:0032926 biolink:NamedThing negative regulation of activin receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway. got7fsn_ti down-regulation of activin receptor signaling pathway|down regulation of activin receptor signaling pathway|negative regulation of activin signaling pathway|negative regulation of activin signalling pathway|inhibition of activin receptor signaling pathway|downregulation of activin receptor signaling pathway|negative regulation of activin receptor signalling pathway biological_process owl:Class
GO:0061295 biolink:NamedThing regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis Any process that modulates the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron in the mesonephros. got7fsn_ti regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis|regulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis dph 2010-09-06T09:48:56Z biological_process owl:Class
GO:0061900 biolink:NamedThing glial cell activation A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor. got7fsn_ti dph 2017-06-13T13:06:23Z biological_process owl:Class
GO:0045622 biolink:NamedThing regulation of T-helper cell differentiation Any process that modulates the frequency, rate or extent of T-helper cell differentiation. got7fsn_ti regulation of T-helper cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:0016120 biolink:NamedThing carotene biosynthetic process The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids. got7fsn_ti carotene biosynthesis|carotene formation|carotene anabolism|carotene synthesis biological_process owl:Class
GO:0033339 biolink:NamedThing pectoral fin development The process whose specific outcome is the progression of the pectoral fin over time, from its formation to the mature structure. got7fsn_ti biological_process owl:Class
GO:0150202 biolink:NamedThing negative regulation of transport across blood-brain barrier Any process that stops, prevents or reduces the frequency, rate or extent of transport across blood-brain barrier. got7fsn_ti bc 2020-03-26T19:28:51Z biological_process owl:Class
GO:1903711 biolink:NamedThing spermidine transmembrane transport The process in which spermidine is transported across a membrane. got7fsn_ti vw 2014-12-06T08:12:44Z biological_process owl:Class
OBO:OPL_0000022 biolink:NamedThing got7fsn_ti owl:Class
GO:0086090 biolink:NamedThing voltage-gated potassium channel activity involved in SA node cell action potential repolarization Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. got7fsn_ti voltage-gated potassium channel activity involved in sinus node cell action potential|voltage-gated potassium channel activity involved in SAN cell action potential|voltage-gated potassium channel activity involved in sinoatrial node cell action potential dph 2011-11-22T01:38:08Z molecular_function owl:Class
GO:0086052 biolink:NamedThing membrane repolarization during SA node cell action potential The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential. got7fsn_ti membrane repolarization involved in regulation of sinoatrial node cardiac muscle cell action potential|membrane repolarization involved in regulation of sinus node cardiac muscle cell action potential|membrane repolarization involved in regulation of SA node cardiac muscle cell action potential|membrane repolarization involved in regulation of SAN cardiac muscle cell action potential dph 2011-11-16T11:54:12Z biological_process owl:Class
GO:1905325 biolink:NamedThing regulation of meiosis I spindle assembly checkpoint Any process that modulates the frequency, rate or extent of the meiosis I spindle assembly checkpoint. got7fsn_ti mah 2016-07-20T12:48:40Z biological_process owl:Class
GO:0015156 biolink:NamedThing melibiose transmembrane transporter activity Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants. got7fsn_ti molecular_function owl:Class
GO:0015769 biolink:NamedThing melibiose transport The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose. got7fsn_ti biological_process owl:Class
GO:0098804 biolink:NamedThing non-motile cilium membrane The portion of the plasma membrane surrounding a non-motile cilium. got7fsn_ti nonmotile primary cilium membrane cellular_component owl:Class
GO:1902678 biolink:NamedThing right caudal basal body Any ciliary basal body that is part of a right caudal flagellum found in Giardia species (trophozoite stage). got7fsn_ti microtubule basal body of right caudal cilium|cilium basal body of right caudal cilium|right caudal flagellum ciliary basal body|cilium basal body of right caudal flagellum|cilial basal body of right caudal flagellum|ciliary basal body of right caudal flagellum|cilial basal body of right caudal cilium|ciliary basal body of right caudal cilium|microtubule basal body of right caudal flagellum Note that we deem cilium and microtubule-based flagellum to be equivalent. Also note that, due to the asymmetric nature of the Giardia trophozoite, this term is defined spatially as the trophozoite is viewed from the dorsal side, with the two nuclei dorsal to the ventral disc, and the ventral disc toward the anterior. pr 2014-02-05T15:02:56Z cellular_component owl:Class
GO:0015169 biolink:NamedThing glycerol-3-phosphate transmembrane transporter activity Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol. got7fsn_ti molecular_function owl:Class
GO:0015794 biolink:NamedThing glycerol-3-phosphate transmembrane transport The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol. got7fsn_ti glycerol-3-phosphate transport biological_process owl:Class
GO:0035231 biolink:NamedThing cytoneme assembly Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell. got7fsn_ti cytoneme biogenesis biological_process owl:Class
GO:0003399 biolink:NamedThing cytoneme morphogenesis The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell. got7fsn_ti dph 2009-12-09T10:03:32Z biological_process owl:Class
GO:1903466 biolink:NamedThing regulation of mitotic DNA replication initiation Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication. got7fsn_ti regulation of DNA replication initiation involved in mitotic cell cycle DNA replication vw 2014-09-23T13:38:49Z biological_process owl:Class
GO:1904451 biolink:NamedThing regulation of potassium:proton exchanging ATPase activity Any process that modulates the frequency, rate or extent of hydrogen:potassium-exchanging ATPase activity. got7fsn_ti regulation of hydrogen:potassium exchanging ATPase activity|regulation of H,K-ATPase activity|regulation of H+-K+-ATPase activity|regulation of hydrogen/potassium-exchanging ATPase activity|regulation of H(+)/K(+)-exchanging ATPase activity|regulation of hydrogen:potassium-exchanging ATPase activity|regulation of gastric H+/K+ ATPase|regulation of H+/K+-exchanging ATPase activity|regulation of (K+ + H+)-ATPase activity|regulation of H(+)/K(+)-ATPase activity|regulation of ATP phosphohydrolase (H+/K+-exchanging)|regulation of H+/K+-ATPase activity|regulation of gastric H(+)/K(+) ATPase activity|regulation of proton pump activity sl 2015-07-08T23:00:03Z biological_process owl:Class
GO:0071923 biolink:NamedThing negative regulation of cohesin loading Any process that stops, prevents, or reduces the frequency, rate or extent of a process in which a cohesin complex is transported to, or maintained at, a part of a chromosome that is organized into chromatin. got7fsn_ti negative regulation of cohesin localisation to chromatin|negative regulation of cohesin localization to chromatin|negative regulation of cohesin association with chromatin mah 2010-09-28T11:17:50Z biological_process owl:Class
GO:0009331 biolink:NamedThing glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. got7fsn_ti cellular_component owl:Class
GO:0071513 biolink:NamedThing phosphopantothenoylcysteine decarboxylase complex A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces. got7fsn_ti See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. mah 2010-01-05T05:23:13Z cellular_component owl:Class
GO:1902072 biolink:NamedThing negative regulation of hypoxia-inducible factor-1alpha signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of hypoxia-inducible factor-1alpha signaling pathway. got7fsn_ti down regulation of HIF1alpha pathway|down regulation of hypoxia-inducible factor-1alpha signaling pathway|negative regulation of HIF1alpha pathway|down-regulation of HIF1alpha pathway|down regulation of hypoxia-inducible factor-1alpha signalling pathway|downregulation of hypoxia-inducible factor-1alpha signaling pathway|inhibition of hypoxia-inducible factor-1alpha signaling pathway|inhibition of hypoxia-inducible factor-1alpha signalling pathway|down-regulation of hypoxia-inducible factor-1alpha signalling pathway|down-regulation of hypoxia-inducible factor-1alpha signaling pathway|downregulation of HIF1alpha pathway|negative regulation of hypoxia-inducible factor-1alpha signalling pathway|inhibition of HIF1alpha pathway|downregulation of hypoxia-inducible factor-1alpha signalling pathway bf 2013-04-18T13:28:25Z biological_process owl:Class
GO:0042478 biolink:NamedThing regulation of eye photoreceptor cell development Any process that modulates the frequency, rate or extent of eye photoreceptor development. got7fsn_ti regulation of eye photoreceptor development biological_process owl:Class
GO:0015908 biolink:NamedThing fatty acid transport The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. got7fsn_ti biological_process owl:Class
GO:0061888 biolink:NamedThing regulation of astrocyte activation Any process that modulates the frequency, rate or extent of astrocyte activation. got7fsn_ti dph 2017-06-01T22:26:29Z biological_process owl:Class
GO:0090368 biolink:NamedThing regulation of ornithine metabolic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. got7fsn_ti tb 2010-07-12T11:14:12Z biological_process owl:Class
GO:0003371 biolink:NamedThing establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell. got7fsn_ti dph 2009-12-08T05:42:46Z biological_process owl:Class
CL:0000850 biolink:NamedThing got7fsn_ti owl:Class
GO:2000268 biolink:NamedThing positive regulation of blood coagulation, intrinsic pathway Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway. got7fsn_ti mah 2010-11-23T11:45:51Z biological_process owl:Class
GO:0110079 biolink:NamedThing regulation of placenta blood vessel development Any process that modulates the frequency, rate or extent of placenta blood vessel development. got7fsn_ti kmv 2018-02-01T14:49:12Z biological_process owl:Class
CHEBI:16247 biolink:NamedThing got7fsn_ti owl:Class
GO:0015153 biolink:NamedThing rhamnose transmembrane transporter activity Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. got7fsn_ti ATP-dependent rhamnose transmembrane transporter activity|ATPase-coupled rhamnose transmembrane transporter activity|rhamnose-transporting ATPase activity https://github.com/geneontology/go-ontology/issues/17289 GO:0033297 RHEA:34995 molecular_function owl:Class
GO:0015762 biolink:NamedThing rhamnose transmembrane transport The process in which rhamnose is transported across a lipid bilayer, from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids. got7fsn_ti rhamnose transport biological_process owl:Class
GO:1904835 biolink:NamedThing dorsal root ganglion morphogenesis The developmental process by which a dorsal root ganglion is generated and organized. got7fsn_ti spinal ganglion part of peripheral nervous system morphogenesis|ganglion spinalis morphogenesis|spinal ganglion morphogenesis|DRG morphogenesis|dorsal root ganglia morphogenesis|ganglion spinale morphogenesis|posterior root ganglion morphogenesis|ganglion of dorsal root morphogenesis|ganglion sensorium nervi spinalis morphogenesis bf 2015-12-01T16:41:17Z biological_process owl:Class
CL:1000050 biolink:NamedThing got7fsn_ti owl:Class
GO:0035727 biolink:NamedThing lysophosphatidic acid binding Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors. got7fsn_ti LPA binding bf 2011-03-10T03:00:05Z molecular_function owl:Class
GO:2000631 biolink:NamedThing regulation of pre-miRNA processing Any process that modulates the frequency, rate or extent of pre-microRNA processing. got7fsn_ti regulation of pre-microRNA processing dph 2011-04-18T03:50:16Z biological_process owl:Class
GO:0070241 biolink:NamedThing positive regulation of activated T cell autonomous cell death Any process that activates or increases the frequency, rate or extent of activated T cell autonomous cell death. got7fsn_ti positive regulation of activated T cell apoptosis|positive regulation of activated T lymphocyte autonomous cell death|stimulation of activated T cell autonomous cell death|positive regulation of activated T-lymphocyte autonomous cell death|upregulation of activated T cell autonomous cell death|up regulation of activated T cell autonomous cell death|activation of activated T cell autonomous cell death|positive regulation of activated cell autonomous cell death|up-regulation of activated T cell autonomous cell death|positive regulation of activated T-cell autonomous cell death|positive regulation of ACAD biological_process owl:Class
GO:0080092 biolink:NamedThing regulation of pollen tube growth Any process that modulates the frequency, rate or extent of pollen tube growth. got7fsn_ti dhl 2009-04-22T04:41:29Z biological_process owl:Class
GO:0009333 biolink:NamedThing cysteine synthase complex Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A. got7fsn_ti cellular_component owl:Class
CL:0000219 biolink:NamedThing got7fsn_ti owl:Class
GO:0009868 biolink:NamedThing jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance. got7fsn_ti jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway|jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)|jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway|jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway|jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway|jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway|jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance) biological_process owl:Class
GO:0032260 biolink:NamedThing response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen. got7fsn_ti response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance biological_process owl:Class
CHEBI:35235 biolink:NamedThing got7fsn_ti owl:Class
UBERON:0001283 biolink:NamedThing got7fsn_ti owl:Class
GO:0015351 biolink:NamedThing bilirubin secondary active transmembrane transporter activity Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. got7fsn_ti bilitranslocase|bilirubin porter activity molecular_function owl:Class
GO:1904259 biolink:NamedThing regulation of basement membrane assembly involved in embryonic body morphogenesis Any process that modulates the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis. got7fsn_ti als 2015-05-21T09:20:43Z biological_process owl:Class
GO:1905874 biolink:NamedThing regulation of postsynaptic density organization Any process that modulates the frequency, rate or extent of postsynaptic density organization. got7fsn_ti regulation of PSD organization|regulation of post synaptic density organization|regulation of postsynaptic density organisation|regulation of post-synaptic density organization sl 2017-01-27T19:53:32Z biological_process owl:Class
GO:0034380 biolink:NamedThing high-density lipoprotein particle assembly The non-covalent aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle. got7fsn_ti HDL assembly biological_process owl:Class
GO:0042943 biolink:NamedThing D-amino acid transmembrane transporter activity Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids. got7fsn_ti D-amino acid transporter activity molecular_function owl:Class
GO:0042940 biolink:NamedThing D-amino acid transport The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:0002907 biolink:NamedThing positive regulation of mature B cell apoptotic process Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process. got7fsn_ti upregulation of mature B cell apoptosis|up-regulation of mature B cell apoptosis|stimulation of mature B cell apoptosis|activation of mature B cell apoptosis|positive regulation of mature B cell apoptosis|up regulation of mature B cell apoptosis biological_process owl:Class
GO:1904179 biolink:NamedThing positive regulation of adipose tissue development Any process that activates or increases the frequency, rate or extent of adipose tissue development. got7fsn_ti up-regulation of adipogenesis|upregulation of adipogenesis|upregulation of adipose tissue development|activation of adipogenesis|up regulation of adipose tissue development|positive regulation of adipogenesis|up regulation of adipogenesis|up-regulation of adipose tissue development|activation of adipose tissue development sl 2015-04-29T20:01:13Z biological_process owl:Class
GO:1903061 biolink:NamedThing positive regulation of protein lipidation Any process that activates or increases the frequency, rate or extent of protein lipidation. got7fsn_ti positive regulation of lipid:protein modification|up-regulation of protein amino acid lipidation|upregulation of lipid:protein modification|up regulation of lipid:protein modification|up-regulation of protein lipidation|upregulation of protein amino acid lipidation|activation of protein lipidation|activation of protein amino acid lipidation|upregulation of protein lipidation|up-regulation of lipid:protein modification|positive regulation of protein amino acid lipidation|up regulation of protein lipidation|up regulation of protein amino acid lipidation|activation of lipid:protein modification rph 2014-05-28T13:21:31Z biological_process owl:Class
GO:1902798 biolink:NamedThing positive regulation of snoRNA processing Any process that activates or increases the frequency, rate or extent of snoRNA processing. got7fsn_ti upregulation of snoRNA processing|up regulation of snoRNA processing|activation of snoRNA processing|up-regulation of snoRNA processing mah 2014-03-24T12:47:20Z biological_process owl:Class
GO:1905366 biolink:NamedThing negative regulation of intralumenal vesicle formation Any process that stops, prevents or reduces the frequency, rate or extent of intralumenal vesicle formation. got7fsn_ti downregulation of endosome membrane budding|down-regulation of intralumenal vesicle formation|downregulation of intralumenal vesicle formation|down regulation of endosome membrane budding|down regulation of intralumenal vesicle formation|down-regulation of endosome membrane budding|negative regulation of endosome membrane budding|inhibition of endosome membrane budding|inhibition of intralumenal vesicle formation bc 2016-08-16T12:00:09Z biological_process owl:Class
GO:0051794 biolink:NamedThing regulation of timing of catagen Any process that modulates the frequency, rate or extent of timing of catagen, the regression phase of the hair cycle. got7fsn_ti regulation of catagen biological_process owl:Class
GO:0015765 biolink:NamedThing methylgalactoside transport The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group. got7fsn_ti biological_process owl:Class
GO:0042765 biolink:NamedThing GPI-anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor. got7fsn_ti GPIT complex Note that this term should not be confused with 'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506', which represents a distinct complex with a different catalytic activity. cellular_component owl:Class
GO:2000143 biolink:NamedThing negative regulation of DNA-templated transcription, initiation Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation. got7fsn_ti negative regulation of DNA-dependent transcription, initiation|negative regulation of initiation of DNA-dependent transcription|negative regulation of transcription initiation, DNA-dependent mah 2010-10-01T09:11:40Z biological_process owl:Class
GO:1900011 biolink:NamedThing negative regulation of corticotropin-releasing hormone receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of corticotropin-releasing hormone receptor activity. got7fsn_ti down regulation of corticotropin-releasing hormone receptor activity|negative regulation of adrenocorticotropin-releasing hormone receptor activity|down regulation of CRF receptor activity|negative regulation of CRF receptor activity|down regulation of CRH receptor activity|down regulation of adrenocorticotropin-releasing hormone receptor activity|negative regulation of corticotropin-releasing factor receptor activity|negative regulation of CRH receptor activity|down regulation of corticotropin-releasing factor receptor activity pr 2012-01-10T02:27:27Z biological_process owl:Class
GO:0043253 biolink:NamedThing chloroplast ribosome A ribosome contained within a chloroplast. got7fsn_ti cellular_component owl:Class
GO:0035435 biolink:NamedThing phosphate ion transmembrane transport The process in which a phosphate is transported across a membrane. got7fsn_ti phosphate ion membrane transport Note that this term is not intended for use in annotating lateral movement within membranes. bf 2010-04-08T11:24:06Z biological_process owl:Class
GO:0072040 biolink:NamedThing negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Any process that reduces the occurrence or rate of mesenchymal stem cell death by apoptotic process that contributes to the shaping of the nephron. got7fsn_ti negative regulation of mesenchymal stem cell apoptosis involved in nephron morphogenesis|negative regulation of mesenchymal stem cell apoptotic process involved in nephron morphogenesis mah 2010-01-25T03:09:30Z biological_process owl:Class
GO:0015098 biolink:NamedThing molybdate ion transmembrane transporter activity Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid. got7fsn_ti molybdate transporter activity molecular_function owl:Class
GO:0090416 biolink:NamedThing nicotinate transmembrane transporter activity Enables the transfer of nicotinate from one side of a membrane to the other. got7fsn_ti tb 2011-10-19T11:09:59Z Reactome:R-HSA-8869603 molecular_function owl:Class
GO:2001142 biolink:NamedThing nicotinate transport The directed movement of a nicotinateacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti tb 2011-10-18T05:09:50Z biological_process owl:Class
GO:2001210 biolink:NamedThing regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway Any process that modulates the frequency, rate or extent of isopentenyl diphosphate biosynthetic process, mevalonate pathway. got7fsn_ti regulation of isopentenyl diphosphate synthesis, mevalonate pathway|regulation of isopentenyl diphosphate formation, mevalonate pathway|regulation of acetate-mevalonate pathway|regulation of Ac-MVA pathway|regulation of isopentenyl diphosphate anabolism, mevalonate pathway bf 2011-11-15T10:53:42Z biological_process owl:Class
GO:1904847 biolink:NamedThing regulation of cell chemotaxis to fibroblast growth factor Any process that modulates the frequency, rate or extent of cell chemotaxis to fibroblast growth factor. got7fsn_ti rph 2015-12-10T12:04:01Z biological_process owl:Class
GO:1901888 biolink:NamedThing regulation of cell junction assembly Any process that modulates the frequency, rate or extent of cell junction assembly. got7fsn_ti tb 2013-02-06T19:40:32Z biological_process owl:Class
GO:1901390 biolink:NamedThing positive regulation of transforming growth factor beta activation Any process that activates or increases the frequency, rate or extent of transforming growth factor beta activation. got7fsn_ti up regulation of TGF-B activation|activation of L-TGF-beta activation|up regulation of TGFbeta activation|up-regulation of L-TGF-beta activation|positive regulation of TGF-B activation|positive regulation of TGFbeta activation|up regulation of TGF-beta activation|positive regulation of L-TGF-beta activation|upregulation of L-TGF-beta activation|upregulation of latent TGF-beta activation|positive regulation of latent TGF-beta activation|activation of TGFB activation|up-regulation of latent TGF-beta activation|up-regulation of TGF-B activation|positive regulation of TGFB activation|up-regulation of TGFB activation|up regulation of latent TGF-beta activation|activation of TGFbeta activation|up-regulation of transforming growth factor beta activation|up regulation of transforming growth factor beta activation|activation of TGF-B activation|upregulation of TGFB activation|up regulation of TGFB activation|up regulation of L-TGF-beta activation|activation of latent TGF-beta activation|up-regulation of TGF-beta activation|upregulation of TGF-beta activation|upregulation of TGFbeta activation|positive regulation of TGF-beta activation|upregulation of transforming growth factor beta activation|activation of TGF-beta activation|activation of transforming growth factor beta activation|upregulation of TGF-B activation|up-regulation of TGFbeta activation bf 2012-10-01T10:33:26Z biological_process owl:Class
GO:2000433 biolink:NamedThing positive regulation of cytokinesis, actomyosin contractile ring assembly Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly. got7fsn_ti positive regulation of contractile ring assembly vw 2011-03-03T12:18:43Z biological_process owl:Class
GO:0150067 biolink:NamedThing regulation of tubulin deacetylase activity Any process that modulates the frequency, rate or extent of tubulin deacetylase activity. got7fsn_ti bc 2018-07-24T10:29:49Z biological_process owl:Class
GO:0015422 biolink:NamedThing ABC-type oligosaccharide transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in). got7fsn_ti ATP-dependent oligosaccharide transmembrane transporter activity|ABC-type oligosaccharide transporter|oligosaccharide-transporting ATPase activity|oligosaccharide ABC transporter|ATPase-coupled oligosaccharide transmembrane transporter activity GO:0015609 MetaCyc:3.6.3.18-RXN|EC:7.5.2.2 molecular_function owl:Class
GO:0015120 biolink:NamedThing phosphoglycerate transmembrane transporter activity Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis. got7fsn_ti molecular_function owl:Class
GO:0015713 biolink:NamedThing phosphoglycerate transmembrane transport The process in which phosphoglycerate is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti phosphoglycerate transport biological_process owl:Class
GO:1901529 biolink:NamedThing positive regulation of anion channel activity Any process that activates or increases the frequency, rate or extent of anion channel activity. got7fsn_ti up regulation of anion channel activity|activation of anion channel activity|upregulation of anion channel activity|up-regulation of anion channel activity tb 2012-10-23T23:38:50Z biological_process owl:Class
GO:0030994 biolink:NamedThing primary cell septum disassembly Dissolution of the primary septum during cell separation. got7fsn_ti primary cell septum hydrolysis|hydrolysis of primary cell septum|primary septum hydrolysis biological_process owl:Class
GO:0015226 biolink:NamedThing carnitine transmembrane transporter activity Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. got7fsn_ti vitamin Bt transporter activity Reactome:R-HSA-549297|Reactome:R-HSA-5625674|Reactome:R-HSA-164967|Reactome:R-HSA-165026 molecular_function owl:Class
GO:1902603 biolink:NamedThing carnitine transmembrane transport The directed movement of carnitine across a membrane. got7fsn_ti pr 2013-12-20T11:09:11Z biological_process owl:Class
GO:0060217 biolink:NamedThing hemangioblast cell differentiation The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages. got7fsn_ti biological_process owl:Class
GO:1901627 biolink:NamedThing negative regulation of postsynaptic membrane organization Any process that stops, prevents or reduces the frequency, rate or extent of postsynaptic membrane organization. got7fsn_ti down regulation of postsynaptic membrane organization|negative regulation of post-synaptic membrane organization|downregulation of postsynaptic membrane organization|negative regulation of postsynaptic membrane organisation|downregulation of postsynaptic membrane organisation|down-regulation of postsynaptic membrane organization|down-regulation of postsynaptic membrane organisation|inhibition of postsynaptic membrane organization|inhibition of postsynaptic membrane organisation|down regulation of postsynaptic membrane organisation ans 2012-11-15T11:40:20Z biological_process owl:Class
GO:0019003 biolink:NamedThing GDP binding Binding to GDP, guanosine 5'-diphosphate. got7fsn_ti molecular_function owl:Class
GO:0015135 biolink:NamedThing glucuronate transmembrane transporter activity Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group. got7fsn_ti molecular_function owl:Class
GO:0015738 biolink:NamedThing glucuronate transmembrane transport The process in which glucuronate is transported across a lipid bilayer, from one side of a membrane to the other. got7fsn_ti glucuronate transport biological_process owl:Class
GO:0031924 biolink:NamedThing vitamin B6 transmembrane transporter activity Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other. got7fsn_ti vitamin B6 transporter activity molecular_function owl:Class
GO:0019549 biolink:NamedThing glutamate catabolic process to succinate via succinate semialdehyde The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase. got7fsn_ti glutamate breakdown to succinate|glutamate degradation to succinate|glutamate catabolic process to succinate via pyruvate-dependent GABA-transaminase activity While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants. MetaCyc:PWY-4321 biological_process owl:Class
GO:0060785 biolink:NamedThing regulation of apoptosis involved in tissue homeostasis Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue. got7fsn_ti dph 2009-07-31T01:49:54Z biological_process owl:Class
GO:0070014 biolink:NamedThing sucrase-isomaltase complex A protein complex that possesses oligo-1,6-glucosidase activity; the complex is a heterodimer located in the cell membrane, and is formed by proteolytic cleavage of a single precursor polypeptide. The two subunits have different substrate specificities. got7fsn_ti oligo-1,6-glucosidase complex Wikipedia:Sucrase-isomaltase cellular_component owl:Class
GO:1904624 biolink:NamedThing regulation of glycine secretion, neurotransmission Any process that modulates the frequency, rate or extent of glycine secretion, neurotransmission. got7fsn_ti hjd 2015-08-27T20:03:38Z biological_process owl:Class
GO:0051282 biolink:NamedThing regulation of sequestering of calcium ion Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system. got7fsn_ti regulation of calcium ion (Ca2+) storage|regulation of storage of calcium ion (Ca2+)|regulation of calcium ion (Ca2+) sequestering|regulation of retention of calcium ion (Ca2+)|regulation of calcium ion (Ca2+) sequestration|regulation of sequestration of calcium ion (Ca2+)|regulation of sequestering of calcium ion (Ca2+)|regulation of calcium ion (Ca2+) retention biological_process owl:Class
GO:1905819 biolink:NamedThing negative regulation of chromosome separation Any process that stops, prevents or reduces the frequency, rate or extent of chromosome separation. got7fsn_ti down regulation of chromosome separation|negative regulation of rDNA separation|downregulation of rDNA separation|downregulation of chromatid release|negative regulation of chromatid release|inhibition of chromatid release|inhibition of rDNA separation|inhibition of chromosome separation|down regulation of rDNA separation|down-regulation of rDNA separation|down regulation of chromatid release|downregulation of chromosome separation|down-regulation of chromosome separation|down-regulation of chromatid release bhm 2017-01-13T13:55:27Z biological_process owl:Class
GO:0060391 biolink:NamedThing positive regulation of SMAD protein signal transduction Any process that increases the rate, frequency or extent of SMAD protein signal transduction. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways. got7fsn_ti positive regulation of SMAD protein nuclear translocation|positive regulation of SMAD protein import into nucleus biological_process owl:Class
GO:1904745 biolink:NamedThing Atg1/ULK1 kinase complex assembly The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex. got7fsn_ti ATG1 kinase complex assembly|ULK1-ATG13-FIP200 complex formation|ULK1-ATG13-FIP200 complex assembly|ULK1-ATG13-RB1CC1 complex formation|ULK1 signaling complex assembly|ATG1/ULK1 signaling complex formation|ULK1-ATG13-RB1CC1 complex assembly|Atg1p signalling complex formation|ULK1 signaling complex formation|ATG1-ATG13 complex formation|ATG1/ULK1 signaling complex assembly|Atg1p signalling complex assembly|ATG1/ULK1 kinase complex formation|ATG1-ATG13 complex assembly|ATG1 kinase complex formation dph 2015-10-19T12:33:08Z biological_process owl:Class
GO:0015248 biolink:NamedThing sterol transporter activity Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. got7fsn_ti Reactome:R-HSA-8868402|Reactome:R-HSA-5679145|Reactome:R-HSA-5250531|Reactome:R-HSA-265783|Reactome:R-HSA-5679101|RHEA:39747|Reactome:R-HSA-8867667 molecular_function owl:Class
GO:0017145 biolink:NamedThing stem cell division The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types. got7fsn_ti stem cell renewal biological_process owl:Class
GO:0070562 biolink:NamedThing regulation of vitamin D receptor signaling pathway Any process that modulates the frequency, rate or extent of vitamin D receptor signaling pathway activity. got7fsn_ti regulation of VDR signaling pathway|regulation of vitamin D receptor signalling pathway mah 2009-04-14T01:46:03Z biological_process owl:Class
GO:0021525 biolink:NamedThing lateral motor column neuron differentiation The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate. got7fsn_ti biological_process owl:Class
GO:0060784 biolink:NamedThing regulation of cell proliferation involved in tissue homeostasis Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue. got7fsn_ti dph 2009-07-31T01:46:28Z biological_process owl:Class
GO:1901860 biolink:NamedThing positive regulation of mitochondrial DNA metabolic process Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process. got7fsn_ti upregulation of mtDNA metabolism|up-regulation of mtDNA metabolism|activation of mtDNA metabolism|up regulation of mtDNA metabolism|positive regulation of mtDNA metabolic process|positive regulation of mtDNA metabolism|upregulation of mtDNA metabolic process|up-regulation of mitochondrial DNA metabolism|upregulation of mitochondrial DNA metabolism|activation of mitochondrial DNA metabolic process|activation of mtDNA metabolic process|upregulation of mitochondrial DNA metabolic process|activation of mitochondrial DNA metabolism|up regulation of mitochondrial DNA metabolic process|up regulation of mtDNA metabolic process|up regulation of mitochondrial DNA metabolism|positive regulation of mitochondrial DNA metabolism|up-regulation of mtDNA metabolic process|up-regulation of mitochondrial DNA metabolic process yaf 2013-02-01T10:05:14Z biological_process owl:Class
GO:1902115 biolink:NamedThing regulation of organelle assembly Any process that modulates the frequency, rate or extent of organelle assembly. got7fsn_ti pr 2013-05-14T09:43:21Z biological_process owl:Class
CHEBI:16113 biolink:NamedThing got7fsn_ti owl:Class
GO:0000100 biolink:NamedThing S-methylmethionine transmembrane transporter activity Enables the transfer of S-methylmethionine from one side of a membrane to the other. got7fsn_ti S-methylmethionine permease activity|S-methylmethionine transporter activity GO:0015178 molecular_function owl:Class
GO:0015806 biolink:NamedThing S-methylmethionine transport The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti biological_process owl:Class
GO:2000330 biolink:NamedThing positive regulation of T-helper 17 cell lineage commitment Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment. got7fsn_ti positive regulation of Th17 cell lineage commitment|positive regulation of Th17 fate commitment|positive regulation of T-helper 17 cell fate commitment mah 2011-01-19T09:32:16Z biological_process owl:Class
GO:0043417 biolink:NamedThing negative regulation of skeletal muscle tissue regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration. got7fsn_ti down-regulation of skeletal muscle regeneration|inhibition of skeletal muscle regeneration|down regulation of skeletal muscle regeneration|downregulation of skeletal muscle regeneration biological_process owl:Class
GO:0045699 biolink:NamedThing positive regulation of synergid differentiation Any process that activates or increases the frequency, rate or extent of synergid cell differentiation. got7fsn_ti upregulation of synergid differentiation|stimulation of synergid differentiation|activation of synergid differentiation|positive regulation of synergid cell differentiation|up-regulation of synergid differentiation|up regulation of synergid differentiation biological_process owl:Class
GO:0045628 biolink:NamedThing regulation of T-helper 2 cell differentiation Any process that modulates the frequency, rate or extent of T-helper 2 cell differentiation. got7fsn_ti regulation of T-helper 2 cell development Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. biological_process owl:Class
GO:1903750 biolink:NamedThing regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to hydrogen peroxide. got7fsn_ti regulation of hydrogen peroxide-induced apoptosis|regulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway|regulation of H2O2-induced intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway in response to H2O2 krc 2014-12-12T23:04:28Z biological_process owl:Class
RO:0002338 biolink:NamedThing has target start location got7fsn_ti RO:0002338|RO:0002338 external|external has_target_start_location|has_target_start_location owl:ObjectProperty
results_in_movement_of biolink:NamedThing results in movement of got7fsn_ti RO:0002565|RO:0002565 external|external results_in_movement_of|results_in_movement_of owl:ObjectProperty
results_in_structural_organization_of biolink:NamedThing results in structural organization of got7fsn_ti RO:0002355|RO:0002355 external|external results_in_structural_organization_of|results_in_structural_organization_of owl:ObjectProperty
RO:0002014 biolink:NamedThing has negative regulatory component activity got7fsn_ti RO:0002014|RO:0002014 external|external has_negative_regulatory_component_activity|has_negative_regulatory_component_activity owl:ObjectProperty
RO:0002131 biolink:NamedThing overlaps got7fsn_ti RO:0002131|RO:0002131 external|external overlaps|overlaps owl:ObjectProperty
GOREL:0000040 biolink:NamedThing results_in got7fsn_ti This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change.|This relation is currently used to connect two regulation processes p1 and p2, such that if r1 regulates p1 and r2 regulates p2, and r1 results_in r2 then the regulation of p1 is required for the regulation of p2. For an example of use, see GO:0035958 'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter'. Note that a precise definition of this relation is under discussion. After it has been formalized it will be added to RO, where it will have a RO ID. Note that the existing identifier and label are subject to change. cjm|cjm 2012-03-14T10:35:44Z|2012-03-14T10:35:44Z GOREL:0000040|GOREL:0000040 external|external results_in|results_in owl:ObjectProperty
RO:0002344 biolink:NamedThing results in transport to from or in got7fsn_ti RO:0002344|RO:0002344 external|external results_in_transport_to_from_or_in|results_in_transport_to_from_or_in owl:ObjectProperty
RO:0002405 biolink:NamedThing immediately causally downstream of got7fsn_ti RO:0002405|RO:0002405 external|external immediately_causally_downstream_of|immediately_causally_downstream_of owl:ObjectProperty
RO:0002298 biolink:NamedThing results in morphogenesis of got7fsn_ti RO:0002298|RO:0002298 external|external results_in_morphogenesis_of|results_in_morphogenesis_of owl:ObjectProperty
RO:0002334 biolink:NamedThing regulated by got7fsn_ti RO:0002334|RO:0002334 external|external regulated_by|regulated_by owl:ObjectProperty
RO:0004008 biolink:NamedThing has primary output got7fsn_ti RO:0004008|RO:0004008 external|external has_primary_output|has_primary_output owl:ObjectProperty
exports biolink:NamedThing exports got7fsn_ti RO:0002345|RO:0002345 external|external exports|exports owl:ObjectProperty
coincident_with biolink:NamedThing coincident with got7fsn_ti RO:0002008|RO:0002008 external|external coincident_with|coincident_with owl:ObjectProperty
RO:0002335 biolink:NamedThing negatively regulated by got7fsn_ti RO:0002335|RO:0002335 external|external negatively_regulated_by|negatively_regulated_by owl:ObjectProperty
RO:0000053 biolink:NamedThing bearer of got7fsn_ti RO:0000053|RO:0000053 external|external bearer_of|bearer_of owl:ObjectProperty
RO:0002356 biolink:NamedThing results in specification of got7fsn_ti RO:0002356|RO:0002356 external|external results_in_specification_of|results_in_specification_of owl:ObjectProperty
has_start_location biolink:NamedThing has start location got7fsn_ti RO:0002231|RO:0002231 external|external has_start_location|has_start_location owl:ObjectProperty
has_primary_input_or_output biolink:NamedThing has primary input or output got7fsn_ti RO:0004007|RO:0004007 external|external has_primary_input_or_output|has_primary_input_or_output owl:ObjectProperty
RO:0002427 biolink:NamedThing causally downstream of or within got7fsn_ti RO:0002427|RO:0002427 external|external causally_downstream_of_or_within|causally_downstream_of_or_within owl:ObjectProperty
RO:0002305 biolink:NamedThing causally upstream of, negative effect got7fsn_ti RO:0002305|RO:0002305 external|external causally_upstream_of,_negative_effect|causally_upstream_of,_negative_effect owl:ObjectProperty
RO:0002348 biolink:NamedThing results in commitment to got7fsn_ti RO:0002348|RO:0002348 external|external results_in_commitment_to|results_in_commitment_to owl:ObjectProperty
RO:0002304 biolink:NamedThing causally upstream of, positive effect got7fsn_ti RO:0002304|RO:0002304 external|external causally_upstream_of,_positive_effect|causally_upstream_of,_positive_effect owl:ObjectProperty
GOREL:0002005 biolink:NamedThing results_in_fusion_of got7fsn_ti GOREL:0002005|GOREL:0002005 results_in_fusion_of|results_in_fusion_of owl:ObjectProperty
RO:0002411 biolink:NamedThing causally upstream of got7fsn_ti RO:0002411|RO:0002411 external|external causally_upstream_of|causally_upstream_of owl:ObjectProperty
RO:0002295 biolink:NamedThing results in developmental progression of got7fsn_ti RO:0002295|RO:0002295 external|external results_in_developmental_progression_of|results_in_developmental_progression_of owl:ObjectProperty
RO:0002091 biolink:NamedThing starts_during got7fsn_ti RO:0002091|RO:0002091 external|external starts_during|starts_during owl:ObjectProperty
RO:0002505 biolink:NamedThing has intermediate got7fsn_ti RO:0002505|RO:0002505 external|external has_intermediate|has_intermediate owl:ObjectProperty
RO:0002315 biolink:NamedThing results in acquisition of features of got7fsn_ti RO:0002315|RO:0002315 external|external results_in_acquisition_of_features_of|results_in_acquisition_of_features_of owl:ObjectProperty
RO:0002234 biolink:NamedThing has output got7fsn_ti RO:0002234|RO:0002234 external|external has_output|has_output owl:ObjectProperty
RO:0002224 biolink:NamedThing starts with got7fsn_ti RO:0002224|RO:0002224 external|external starts_with|starts_with owl:ObjectProperty
RO:0002313 biolink:NamedThing transports or maintains localization of got7fsn_ti RO:0002313|RO:0002313 external|external transports_or_maintains_localization_of|transports_or_maintains_localization_of owl:ObjectProperty
RO:0002230 biolink:NamedThing ends with got7fsn_ti RO:0002230|RO:0002230 external|external ends_with|ends_with owl:ObjectProperty
RO:0002090 biolink:NamedThing immediately_precedes got7fsn_ti RO:0002090|RO:0002090 external|external immediately_precedes|immediately_precedes owl:ObjectProperty
BFO:0000066 biolink:NamedThing occurs in got7fsn_ti BFO:0000066|BFO:0000066 external|external occurs_in|occurs_in owl:ObjectProperty
RO:0002299 biolink:NamedThing results in maturation of got7fsn_ti RO:0002299|RO:0002299 external|external results_in_maturation_of|results_in_maturation_of owl:ObjectProperty
RO:0002343 biolink:NamedThing results in growth of got7fsn_ti RO:0002343|RO:0002343 external|external results_in_growth_of|results_in_growth_of owl:ObjectProperty
RO:0002232 biolink:NamedThing has end location got7fsn_ti RO:0002232|RO:0002232 external|external has_end_location|has_end_location owl:ObjectProperty
RO:0002016 biolink:NamedThing has necessary component activity got7fsn_ti RO:0002016|RO:0002016 external|external has_necessary_component_activity|has_necessary_component_activity owl:ObjectProperty
RO:0002339 biolink:NamedThing has target end location got7fsn_ti RO:0002339|RO:0002339 external|external has_target_end_location|has_target_end_location owl:ObjectProperty
has_component biolink:NamedThing has component got7fsn_ti RO:0002180|RO:0002180 external|external has_component|has_component owl:ObjectProperty
imports biolink:NamedThing imports got7fsn_ti RO:0002340|RO:0002340 external|external imports|imports owl:ObjectProperty
OBO:go/extensions/ro_pending#results_in_transport_through biolink:NamedThing obsolete results_in_transport_through got7fsn_ti True|True owl:ObjectProperty
RO:0002087 biolink:NamedThing immediately_preceded_by got7fsn_ti RO:0002087|RO:0002087 external|external immediately_preceded_by|immediately_preceded_by owl:ObjectProperty
RO:0002215 biolink:NamedThing capable of got7fsn_ti RO:0002215|RO:0002215 external|external capable_of|capable_of owl:ObjectProperty
RO:0002296 biolink:NamedThing results in development of got7fsn_ti RO:0002296|RO:0002296 external|external results_in_development_of|results_in_development_of owl:ObjectProperty
RO:0002233 biolink:NamedThing has input got7fsn_ti RO:0002233|RO:0002233 external|external has_input|has_input owl:ObjectProperty
RO:0002418 biolink:NamedThing causally upstream of or within got7fsn_ti RO:0002418|RO:0002418 external|external causally_upstream_of_or_within|causally_upstream_of_or_within owl:ObjectProperty
OBO:go/extensions/ro_pending#alters_location_of biolink:NamedThing obsolete alters location of got7fsn_ti True|True owl:ObjectProperty
RO:0002013 biolink:NamedThing has regulatory component activity got7fsn_ti RO:0002013|RO:0002013 external|external has_regulatory_component_activity|has_regulatory_component_activity owl:ObjectProperty
RO:0002336 biolink:NamedThing positively regulated by got7fsn_ti RO:0002336|RO:0002336 external|external positively_regulated_by|positively_regulated_by owl:ObjectProperty
has_intermediate biolink:NamedThing obsolete has intermediate got7fsn_ti Replaced by RO_0002505.|Replaced by RO_0002505. True|True GOREL:0002008|GOREL:0002008 has_intermediate|has_intermediate owl:ObjectProperty
participates_in biolink:NamedThing participates_in got7fsn_ti RO:0000056|RO:0000056 external|external participates_in|participates_in owl:ObjectProperty
has_primary_input biolink:NamedThing has primary input got7fsn_ti RO:0004009|RO:0004009 external|external has_primary_input|has_primary_input owl:ObjectProperty
RO:0002349 biolink:NamedThing results in determination of got7fsn_ti RO:0002349|RO:0002349 external|external results_in_determination_of|results_in_determination_of owl:ObjectProperty
RO:0002220 biolink:NamedThing adjacent to got7fsn_ti RO:0002220|RO:0002220 external|external adjacent_to|adjacent_to owl:ObjectProperty
RO:0002341 biolink:NamedThing results in transport along got7fsn_ti RO:0002341|RO:0002341 external|external results_in_transport_along|results_in_transport_along owl:ObjectProperty
RO:0002007 biolink:NamedThing bounding layer of got7fsn_ti RO:0002007|RO:0002007 external|external bounding_layer_of|bounding_layer_of owl:ObjectProperty
RO:0002342 biolink:NamedThing results in transport across got7fsn_ti RO:0002342|RO:0002342 external|external results_in_transport_across|results_in_transport_across owl:ObjectProperty
RO:0002353 biolink:NamedThing output of got7fsn_ti RO:0002353|RO:0002353 external|external output_of|output_of owl:ObjectProperty
RO:0003000 biolink:NamedThing produces got7fsn_ti RO:0003000|RO:0003000 external|external produces|produces owl:ObjectProperty
RO:0002297 biolink:NamedThing results in formation of got7fsn_ti RO:0002297|RO:0002297 external|external results_in_formation_of|results_in_formation_of owl:ObjectProperty
BFO:0000063 biolink:NamedThing precedes got7fsn_ti BFO:0000063|BFO:0000063 external|external precedes|precedes owl:ObjectProperty
RO:0002332 biolink:NamedThing regulates levels of got7fsn_ti RO:0002332|RO:0002332 external|external regulates_levels_of|regulates_levels_of owl:ObjectProperty
RO:0002160 biolink:NamedThing got7fsn_ti owl:ObjectProperty
RO:0002162 biolink:NamedThing got7fsn_ti owl:ObjectProperty
RO:0002216 biolink:NamedThing capable of part of got7fsn_ti RO:0002216|RO:0002216 external|external capable_of_part_of|capable_of_part_of owl:ObjectProperty
results_in_distribution_of biolink:NamedThing results_in_distribution_of got7fsn_ti GOREL:0002003|GOREL:0002003 external|external results_in_distribution_of|results_in_distribution_of owl:ObjectProperty
BFO:0000062 biolink:NamedThing preceded by got7fsn_ti BFO:0000062|BFO:0000062 external|external preceded_by|preceded_by owl:ObjectProperty
immediately_causally_upstream_of biolink:NamedThing immediately causally upstream of got7fsn_ti RO:0002412|RO:0002412 external|external immediately_causally_upstream_of|immediately_causally_upstream_of owl:ObjectProperty
RO:0002404 biolink:NamedThing causally downstream of got7fsn_ti RO:0002404|RO:0002404 external|external causally_downstream_of|causally_downstream_of owl:ObjectProperty
RO:0003001 biolink:NamedThing produced by got7fsn_ti RO:0003001|RO:0003001 external|external produced_by|produced_by owl:ObjectProperty
process_has_causal_agent biolink:NamedThing process has causal agent got7fsn_ti RO:0002608|RO:0002608 external|external process_has_causal_agent|process_has_causal_agent owl:ObjectProperty
GO:1900376 biolink:NamedThing regulation of secondary metabolite biosynthetic process Any process that modulates the frequency, rate or extent of secondary metabolite biosynthetic process. got7fsn_ti regulation of secondary metabolite biosynthesis di 2012-04-17T01:55:23Z biological_process owl:Class
GO:1903771 biolink:NamedThing positive regulation of beta-galactosidase activity Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity. got7fsn_ti upregulation of hydrolact|up regulation of maxilact|up regulation of beta-D-lactosidase activity|activation of lactozym|up-regulation of beta-D-lactosidase activity|up regulation of oryzatym|up-regulation of sumiklat|up-regulation of beta-galactosidase activity|positive regulation of beta-D-lactosidase activity|positive regulation of beta-D-galactoside galactohydrolase activity|positive regulation of lactose hydrolysis|activation of trilactase activity|up-regulation of beta-D-galactanase activity|upregulation of oryzatym|positive regulation of sumiklat|upregulation of beta-D-galactanase activity|up regulation of beta-lactosidase activity|up-regulation of lactozym|upregulation of exo-(1->4)-beta-D-galactanase activity|positive regulation of maxilact|up-regulation of trilactase activity|up-regulation of beta-D-galactoside galactohydrolase activity|upregulation of trilactase activity|up regulation of exo-(1->4)-beta-D-galactanase activity|upregulation of beta-lactosidase activity|up regulation of beta-D-galactanase activity|activation of beta-D-galactoside galactohydrolase activity|activation of exo-(1->4)-beta-D-galactanase activity|positive regulation of beta-lactosidase activity|activation of beta-D-galactanase activity|upregulation of beta-D-lactosidase activity|activation of hydrolact|upregulation of S 2107|upregulation of maxilact|up regulation of lactose hydrolysis|up-regulation of maxilact|up-regulation of oryzatym|up-regulation of exo-(1->4)-beta-D-galactanase activity|activation of maxilact|activation of oryzatym|activation of beta-D-lactosidase activity|up regulation of trilactase activity|up regulation of hydrolact|positive regulation of beta-D-galactanase activity|positive regulation of lactozym|up-regulation of beta-lactosidase activity|up-regulation of hydrolact|upregulation of lactozym|upregulation of beta-D-galactoside galactohydrolase activity|upregulation of sumiklat|upregulation of lactose hydrolysis|activation of lactose hydrolysis|activation of beta-galactosidase activity|activation of S 2107|positive regulation of trilactase activity|up-regulation of S 2107|up regulation of sumiklat|activation of sumiklat|positive regulation of S 2107|positive regulation of oryzatym|up-regulation of lactose hydrolysis|up regulation of beta-galactosidase activity|activation of beta-lactosidase activity|up regulation of lactozym|up regulation of beta-D-galactoside galactohydrolase activity|up regulation of S 2107|positive regulation of hydrolact|positive regulation of exo-(1->4)-beta-D-galactanase activity|upregulation of beta-galactosidase activity nc 2015-01-06T10:53:32Z biological_process owl:Class
GO:1900502 biolink:NamedThing positive regulation of butyryl-CoA catabolic process to butyrate Any process that activates or increases the frequency, rate or extent of butyryl-CoA catabolic process to butyrate. got7fsn_ti up-regulation of butyryl-CoA catabolism to butyrate|positive regulation of butyryl-CoA catabolism to butyrate|up-regulation of butyryl-CoA catabolic process to butyrate|upregulation of butyryl-CoA catabolism to butyrate|activation of butyryl-CoA catabolic process to butyrate|up regulation of butyryl-CoA catabolic process to butyrate|activation of butyryl-CoA catabolism to butyrate|upregulation of butyryl-CoA catabolic process to butyrate|up regulation of butyryl-CoA catabolism to butyrate tt 2012-05-02T03:56:40Z biological_process owl:Class
GO:1905693 biolink:NamedThing regulation of phosphatidic acid biosynthetic process Any process that modulates the frequency, rate or extent of phosphatidic acid biosynthetic process. got7fsn_ti regulation of phosphatidic acid formation|regulation of phosphatidic acid biosynthesis|regulation of phosphatidic acid synthesis|regulation of phosphatidic acid anabolism bc 2016-11-14T14:48:09Z biological_process owl:Class
GO:0120040 biolink:NamedThing regulation of macrophage proliferation Any process that modulates the frequency, rate or extent of macrophage proliferation. got7fsn_ti krc 2017-05-10T20:38:19Z biological_process owl:Class
GO:1902336 biolink:NamedThing positive regulation of retinal ganglion cell axon guidance Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance. got7fsn_ti upregulation of retinal ganglion cell axon guidance|positive regulation of retinal ganglion cell axon pathfinding|activation of retinal ganglion cell axon pathfinding|up regulation of retinal ganglion cell axon guidance|activation of retinal ganglion cell axon guidance|upregulation of retinal ganglion cell axon pathfinding|up regulation of retinal ganglion cell axon pathfinding|up-regulation of retinal ganglion cell axon guidance|up-regulation of retinal ganglion cell axon pathfinding rl 2013-07-29T13:02:25Z biological_process owl:Class
GO:1900735 biolink:NamedThing positive regulation of flocculation Any process that activates or increases the frequency, rate or extent of flocculation. got7fsn_ti upregulation of flocculation via cell wall protein-carbohydrate interaction|upregulation of flocculation|activation of flocculation|up-regulation of flocculation via cell wall protein-carbohydrate interaction|up regulation of flocculation|activation of flocculation via cell wall protein-carbohydrate interaction|up regulation of flocculation via cell wall protein-carbohydrate interaction|positive regulation of flocculation via cell wall protein-carbohydrate interaction|up-regulation of flocculation dgf 2012-05-27T08:27:38Z GO:1900479 biological_process owl:Class
GO:1901409 biolink:NamedThing positive regulation of phosphorylation of RNA polymerase II C-terminal domain Any process that activates or increases the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain. got7fsn_ti up regulation of hyperphosphorylation of RNA polymerase II C-terminal domain|activation of CTD domain phosphorylation of RNA polymerase II|up regulation of generation of II(0) form of RNA polymerase II|activation of generation of II(0) form of RNA polymerase II|positive regulation of generation of hyperphosphorylated CTD of RNA polymerase II|up regulation of CTD domain phosphorylation of RNA polymerase II|upregulation of CTD domain phosphorylation of RNA polymerase II|upregulation of phosphorylation of RNA polymerase II C-terminal domain|up-regulation of generation of II(0) form of RNA polymerase II|positive regulation of generation of II(0) form of RNA polymerase II|up-regulation of generation of hyperphosphorylated CTD of RNA polymerase II|activation of generation of hyperphosphorylated CTD of RNA polymerase II|up regulation of phosphorylation of RNA polymerase II C-terminal domain|upregulation of hyperphosphorylation of RNA polymerase II C-terminal domain|activation of phosphorylation of RNA polymerase II C-terminal domain|positive regulation of CTD domain phosphorylation of RNA polymerase II|positive regulation of hyperphosphorylation of RNA polymerase II C-terminal domain|activation of hyperphosphorylation of RNA polymerase II C-terminal domain|up-regulation of hyperphosphorylation of RNA polymerase II C-terminal domain|upregulation of generation of II(0) form of RNA polymerase II|upregulation of generation of hyperphosphorylated CTD of RNA polymerase II|up-regulation of phosphorylation of RNA polymerase II C-terminal domain|up regulation of generation of hyperphosphorylated CTD of RNA polymerase II|up-regulation of CTD domain phosphorylation of RNA polymerase II vw 2012-10-01T14:41:15Z biological_process owl:Class
GO:1904354 biolink:NamedThing negative regulation of telomere capping Any process that stops, prevents or reduces the frequency, rate or extent of telomere capping. got7fsn_ti inhibition of telomere capping|down-regulation of telomere end protection|down-regulation of telomere capping|down regulation of telomere capping|down regulation of telomere end protection|negative regulation of telomere end protection|downregulation of telomere capping|downregulation of telomere end protection|inhibition of telomere end protection nc 2015-06-12T16:51:14Z biological_process owl:Class
GO:0034124 biolink:NamedThing regulation of MyD88-dependent toll-like receptor signaling pathway Any process that modulates the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway. got7fsn_ti regulation ofMyD88-dependent TLR signaling pathway|regulation ofMyD88-dependent toll-like receptor signalling pathway biological_process owl:Class
GO:2000396 biolink:NamedThing negative regulation of ubiquitin-dependent endocytosis Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis. got7fsn_ti negative regulation of ubiquitin-mediated endocytosis mah 2011-02-22T11:25:21Z biological_process owl:Class
GO:0010743 biolink:NamedThing regulation of macrophage derived foam cell differentiation Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions. got7fsn_ti biological_process owl:Class
GO:0034171 biolink:NamedThing regulation of toll-like receptor 11 signaling pathway Any process that modulates the frequency, rate, or extent of toll-like receptor 11 signaling pathway. got7fsn_ti regulation of toll-like receptor 11 signalling pathway|regulation of TLR11 signaling pathway biological_process owl:Class
GO:0035067 biolink:NamedThing negative regulation of histone acetylation Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. got7fsn_ti down regulation of histone acetylation|downregulation of histone acetylation|down-regulation of histone acetylation|inhibition of histone acetylation biological_process owl:Class
GO:1900824 biolink:NamedThing positive regulation of ergot alkaloid biosynthetic process Any process that activates or increases the frequency, rate or extent of ergot alkaloid biosynthetic process. got7fsn_ti upregulation of ergot alkaloid biosynthesis|up-regulation of ergot alkaloid formation|upregulation of ergot alkaloid formation|positive regulation of ergot alkaloid formation|positive regulation of ergot alkaloid anabolism|up regulation of ergot alkaloid biosynthesis|up regulation of ergot alkaloid anabolism|up-regulation of ergot alkaloid biosynthesis|upregulation of ergot alkaloid synthesis|activation of ergot alkaloid anabolism|up regulation of ergot alkaloid biosynthetic process|positive regulation of ergot alkaloid synthesis|positive regulation of ergot alkaloid biosynthesis|activation of ergot alkaloid biosynthetic process|up-regulation of ergot alkaloid biosynthetic process|activation of ergot alkaloid synthesis|up regulation of ergot alkaloid formation|upregulation of ergot alkaloid anabolism|up-regulation of ergot alkaloid anabolism|upregulation of ergot alkaloid biosynthetic process|activation of ergot alkaloid formation|activation of ergot alkaloid biosynthesis|up-regulation of ergot alkaloid synthesis|up regulation of ergot alkaloid synthesis di 2012-06-04T11:13:05Z biological_process owl:Class
GO:1900706 biolink:NamedThing positive regulation of siderophore biosynthetic process Any process that activates or increases the frequency, rate or extent of siderophore biosynthetic process. got7fsn_ti up-regulation of siderophore anabolism|up-regulation of siderophore biosynthetic process, peptide formation|up-regulation of siderophore synthesis|up-regulation of siderophore biosynthesis|up-regulation of siderophore biosynthetic process, peptide modification|upregulation of siderophore biosynthetic process|activation of siderophore synthesis|up-regulation of siderochrome biosynthetic process|upregulation of siderophore formation|positive regulation of siderochrome biosynthetic process|up regulation of siderophore anabolism|positive regulation of siderophore anabolism|upregulation of siderophore anabolism|up regulation of siderochrome biosynthesis|up regulation of siderophore synthesis|activation of siderophore anabolism|upregulation of siderophore biosynthetic process, peptide modification|activation of siderochrome biosynthesis|positive regulation of siderochrome biosynthesis|activation of siderophore biosynthetic process, peptide modification|upregulation of siderophore biosynthesis|positive regulation of siderophore synthesis|activation of siderophore biosynthetic process|up regulation of siderophore biosynthetic process, peptide formation|up-regulation of siderophore biosynthetic process|up-regulation of siderochrome biosynthesis|up-regulation of siderophore formation|up regulation of siderophore biosynthetic process, peptide modification|positive regulation of siderophore biosynthetic process, peptide formation|activation of siderophore biosynthesis|upregulation of siderochrome biosynthesis|activation of siderochrome biosynthetic process|up regulation of siderophore formation|upregulation of siderochrome biosynthetic process|activation of siderophore formation|upregulation of siderophore synthesis|positive regulation of siderophore biosynthesis|up regulation of siderochrome biosynthetic process|up regulation of siderophore biosynthesis|positive regulation of siderophore biosynthetic process, peptide modification|positive regulation of siderophore formation|up regulation of siderophore biosynthetic process|activation of siderophore biosynthetic process, peptide formation|upregulation of siderophore biosynthetic process, peptide formation di 2012-05-22T05:00:00Z biological_process owl:Class
GO:0106042 biolink:NamedThing negative regulation of GABA-A receptor activity Any process that stops, prevents or reduces the frequency, rate or extent of GABA-A receptor activity. got7fsn_ti hjd 2017-07-27T18:55:03Z biological_process owl:Class
GO:1904460 biolink:NamedThing positive regulation of substance P secretion Any process that activates or increases the frequency, rate or extent of substance P secretion. got7fsn_ti upregulation of substance P secretion|activation of substance P secretion|up-regulation of substance P secretion|up regulation of substance P secretion sl 2015-07-09T19:33:03Z biological_process owl:Class
GO:1902442 biolink:NamedThing regulation of ripoptosome assembly involved in necroptotic process Any process that modulates the frequency, rate or extent of ripoptosome assembly involved in a necroptotic process. got7fsn_ti regulation of ripoptosome assembly involved in necroptosis dph 2013-10-10T17:51:33Z biological_process owl:Class
GO:1902901 biolink:NamedThing positive regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion Any positive regulation of transcription from RNA polymerase II promoter that is involved in stress response to cadmium ion. got7fsn_ti up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|activation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium toxicity|positive regulation of transcription from Pol II promoter involved in stress response to cadmium ion|up-regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|positive regulation of transcription from Pol II promoter involved in response to cadmium ion stress|up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|positive regulation of global transcription from Pol II promoter involved in response to cadmium ion stress|stimulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|up regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|activation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|stimulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|upregulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|stimulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|stimulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|up regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|upregulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|up regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|stimulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|upregulation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|activation of global transcription from RNA polymerase II promoter involved in response to cadmium ion stress|positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|positive regulation of transcription from Pol II promoter involved in response to cadmium toxicity|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in response to cadmium ion stress|activation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|up regulation of transcription from RNA polymerase II promoter involved in response to cadmium toxicity|up-regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|activation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|upregulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress|up regulation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|positive regulation of global transcription from Pol II promoter involved in response to cadmium toxicity|up-regulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|upregulation of global transcription from RNA polymerase II promoter involved in stress response to cadmium ion|positive regulation of gene-specific transcription from RNA polymerase II promoter involved in stress response to cadmium ion|positive regulation of global transcription from Pol II promoter involved in stress response to cadmium ion|activation of transcription from RNA polymerase II promoter involved in stress response to cadmium ion|up-regulation of global transcription from RNA polymerase II promoter involved in response to cadmium toxicity|positive regulation of transcription from RNA polymerase II promoter involved in response to cadmium ion stress kmv 2014-04-14T18:03:42Z biological_process owl:Class
GO:2000465 biolink:NamedThing regulation of glycogen (starch) synthase activity Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity. got7fsn_ti regulation of UDP-glycogen synthase activity|regulation of uridine diphosphoglucose-glycogen glucosyltransferase activity|regulation of UDPG-glycogen synthetase activity|regulation of glycogen (starch) synthetase activity|regulation of UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity|regulation of UDPG-glycogen transglucosylase activity|regulation of UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity|regulation of UDP-glucose-glycogen glucosyltransferase activity yaf 2011-03-07T04:12:35Z biological_process owl:Class
GO:1904565 biolink:NamedThing response to 1-oleoyl-sn-glycerol 3-phosphate Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-oleoyl-sn-glycerol 3-phosphate stimulus. got7fsn_ti response to LPA|response to 1-oleoyl lysophosphatidic acid|response to oleoyl-L-alpha-lysophosphatidic acid|response to lysophosphatidic acid|response to oleoyl lysophosphatidic acid sl 2015-08-19T15:36:48Z biological_process owl:Class
GO:0030805 biolink:NamedThing regulation of cyclic nucleotide catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides. got7fsn_ti regulation of cyclic nucleotide degradation|regulation of cyclic nucleotide catabolism|regulation of cyclic nucleotide breakdown biological_process owl:Class
GO:1903290 biolink:NamedThing obsolete negative regulation of ATP catabolic process OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of ATP catabolic process. got7fsn_ti negative regulation of ATP hydrolysis|down-regulation of ATP breakdown|negative regulation of ATP catabolism|inhibition of ATP breakdown|negative regulation of ATP breakdown|down-regulation of ATP catabolism|downregulation of ATP catabolism|inhibition of ATP catabolic process|down-regulation of ATP catabolic process|down regulation of ATP hydrolysis|down-regulation of ATP hydrolysis|down regulation of ATP breakdown|downregulation of ATP breakdown|down regulation of ATP degradation|downregulation of ATP hydrolysis|negative regulation of ATP degradation|down regulation of ATP catabolic process|down-regulation of ATP degradation|inhibition of ATP hydrolysis|inhibition of ATP catabolism|inhibition of ATP degradation|downregulation of ATP degradation|down regulation of ATP catabolism|downregulation of ATP catabolic process The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. GO:0032780 rl 2014-08-11T14:36:47Z True biological_process owl:Class
GO:1903516 biolink:NamedThing regulation of single strand break repair Any process that modulates the frequency, rate or extent of single strand break repair. got7fsn_ti rl 2014-10-06T10:58:52Z biological_process owl:Class
GO:1903817 biolink:NamedThing negative regulation of voltage-gated potassium channel activity Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity. got7fsn_ti downregulation of voltage-gated potassium ion channel activity|downregulation of voltage gated potassium channel activity|downregulation of voltage-dependent potassium channel activity|down regulation of voltage-gated potassium channel activity|negative regulation of voltage-gated potassium ion channel activity|downregulation of voltage-sensitive potassium channel|down regulation of voltage-sensitive potassium channel|down regulation of voltage-dependent potassium channel activity|down-regulation of voltage-dependent potassium channel activity|inhibition of voltage-dependent potassium channel activity|down-regulation of voltage gated potassium channel activity|down regulation of voltage gated potassium channel activity|inhibition of voltage-gated potassium channel activity|down-regulation of voltage-gated potassium ion channel activity|down-regulation of voltage-sensitive potassium channel|negative regulation of voltage gated potassium channel activity|inhibition of voltage-sensitive potassium channel|inhibition of voltage-gated potassium ion channel activity|negative regulation of voltage-sensitive potassium channel|down-regulation of voltage-gated potassium channel activity|downregulation of voltage-gated potassium channel activity|inhibition of voltage gated potassium channel activity|down regulation of voltage-gated potassium ion channel activity|negative regulation of voltage-dependent potassium channel activity sl 2015-01-16T17:22:08Z biological_process owl:Class
GO:0032592 biolink:NamedThing integral component of mitochondrial membrane The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. got7fsn_ti integral to mitochondrial membrane cellular_component owl:Class
GO:0001603 biolink:NamedThing obsolete vasopressin-like receptor activity OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti vasopressin-like receptor activity True molecular_function owl:Class
GO:0010777 biolink:NamedThing meiotic mismatch repair involved in reciprocal meiotic recombination A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. got7fsn_ti biological_process owl:Class
GO:1903243 biolink:NamedThing negative regulation of cardiac muscle hypertrophy in response to stress Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. got7fsn_ti downregulation of cardiac muscle hypertrophy in response to stress|down regulation of cardiac muscle hypertrophy in response to stress|down-regulation of cardiac muscle hypertrophy in response to stress|inhibition of cardiac muscle hypertrophy in response to stress rl 2014-08-01T16:31:42Z biological_process owl:Class
GO:1904898 biolink:NamedThing negative regulation of hepatic stellate cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell proliferation. got7fsn_ti downregulation of perisinusoidal cell proliferation|down regulation of hepatic stellate cell proliferation|negative regulation of perisinusoidal cell proliferation|down-regulation of hepatic stellate cell proliferation|inhibition of Ito cell proliferation|down-regulation of Ito cell proliferation|downregulation of Ito cell proliferation|down regulation of perisinusoidal cell proliferation|downregulation of hepatic perisinusoidal cell proliferation|down-regulation of perisinusoidal cell proliferation|inhibition of hepatic stellate cell proliferation|down-regulation of hepatic perisinusoidal cell proliferation|negative regulation of Ito cell proliferation|down regulation of Ito cell proliferation|negative regulation of hepatic perisinusoidal cell proliferation|down regulation of hepatic perisinusoidal cell proliferation|inhibition of perisinusoidal cell proliferation|inhibition of hepatic perisinusoidal cell proliferation|downregulation of hepatic stellate cell proliferation sl 2016-01-14T15:57:06Z biological_process owl:Class
GO:0052139 biolink:NamedThing obsolete negative chemotaxis in host OBSOLETE. The directed movement of a motile cell or organism towards a lower concentration of a specific chemical within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction. got7fsn_ti negative chemotaxis within host https://github.com/geneontology/go-ontology/issues/18819 This term was obsoleted because it represents both a process and a location. True biological_process owl:Class
GO:0071268 biolink:NamedThing homocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid. got7fsn_ti homocysteine biosynthesis|homocysteine formation|homocysteine anabolism|homocysteine synthesis mah 2009-12-09T05:32:48Z biological_process owl:Class
GO:0072369 biolink:NamedThing obsolete regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter This term was obsoleted because it represents a GO-CAM model. mah 2010-11-16T03:23:53Z True biological_process owl:Class
GO:0003252 biolink:NamedThing negative regulation of cell proliferation involved in heart valve morphogenesis Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve. got7fsn_ti dph 2009-10-13T02:10:39Z biological_process owl:Class
GO:1904752 biolink:NamedThing regulation of vascular associated smooth muscle cell migration Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration. got7fsn_ti regulation of vascular smooth muscle cell migration rph 2015-10-19T15:49:52Z biological_process owl:Class
GO:1902590 biolink:NamedThing multi-organism organelle organization An organelle organization which involves another organism. got7fsn_ti multi organism organelle organization jl 2013-12-19T15:26:08Z biological_process owl:Class
GO:0030415 biolink:NamedThing obsolete carboxypeptidase A inhibitor activity OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A. got7fsn_ti carboxypeptidase A inhibitor activity GO:0030414 This term was made obsolete because it represents a regulator of an obsolete molecular function. True molecular_function owl:Class
GO:0016100 biolink:NamedThing monoterpenoid catabolic process The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton. got7fsn_ti monoterpenoid degradation|monoterpenoid breakdown|monoterpenoid catabolism biological_process owl:Class
GO:1902213 biolink:NamedThing positive regulation of prolactin signaling pathway Any process that activates or increases the frequency, rate or extent of prolactin signaling pathway. got7fsn_ti up-regulation of PRL signaling pathway|positive regulation of PRL signaling pathway|positive regulation of prolactin-mediated signaling pathway|upregulation of prolactin-mediated signaling pathway|up regulation of prolactin-mediated signaling pathway|up regulation of prolactin signaling pathway|up-regulation of prolactin-mediated signaling pathway|activation of prolactin signaling pathway|upregulation of prolactin signaling pathway|activation of PRL signaling pathway|up-regulation of prolactin signaling pathway|activation of prolactin-mediated signaling pathway|upregulation of PRL signaling pathway|up regulation of PRL signaling pathway lb 2013-06-12T10:10:18Z biological_process owl:Class
GO:0051491 biolink:NamedThing positive regulation of filopodium assembly Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. got7fsn_ti positive regulation of filopodia formation|up-regulation of filopodium formation|upregulation of filopodium formation|positive regulation of filopodia biosynthesis|stimulation of filopodium formation|up regulation of filopodium formation|positive regulation of filopodium formation|activation of filopodium formation biological_process owl:Class
GO:0060754 biolink:NamedThing positive regulation of mast cell chemotaxis Any process that increases the rate, frequency or extent of mast cell chemotaxis. Mast cell chemotaxis is the movement of a mast cell in response to an external stimulus. got7fsn_ti dph 2009-06-22T02:38:19Z biological_process owl:Class
GO:1902637 biolink:NamedThing neural crest cell differentiation involved in thymus development Any neural crest cell differentiation that is involved in thymus development. got7fsn_ti pr 2014-01-21T10:03:20Z biological_process owl:Class
GO:0035020 biolink:NamedThing regulation of Rac protein signal transduction Any process that modulates the frequency, rate or extent of Rac protein signal transduction. got7fsn_ti biological_process owl:Class
GO:0030068 biolink:NamedThing obsolete lytic viral life cycle OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti lytic viral life cycle This term was made obsolete because more specific terms were created. GO:0044659|GO:0019058 True biological_process owl:Class
GO:0061006 biolink:NamedThing regulation of cell proliferation involved in kidney morphogenesis Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney. got7fsn_ti dph 2010-01-21T11:25:23Z biological_process owl:Class
CHEBI:128769 biolink:NamedThing got7fsn_ti owl:Class
GO:0003966 biolink:NamedThing obsolete RNA-directed DNA polymerase, transposon encoded OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo. got7fsn_ti RNA-directed DNA polymerase, transposon encoded GO:0003964 This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. True molecular_function owl:Class
GO:1904138 biolink:NamedThing positive regulation of convergent extension involved in notochord morphogenesis Any process that activates or increases the frequency, rate or extent of convergent extension involved in notochord morphogenesis. got7fsn_ti activation of convergent extension involved in notochord morphogenesis|up-regulation of convergent extension involved in notochord morphogenesis|upregulation of convergent extension involved in notochord morphogenesis|up regulation of convergent extension involved in notochord morphogenesis dph 2015-04-10T21:21:41Z biological_process owl:Class
GO:0060357 biolink:NamedThing regulation of leucine import Any process that modulates the rate, frequency or extent of leucine import. Leucine import is the directed movement of leucine into a cell or organelle. got7fsn_ti regulation of L-leucine import|regulation of L-leucine uptake|regulation of leucine uptake biological_process owl:Class
GO:1904919 biolink:NamedThing transmembrane L-cystine transport from lysosomal lumen to cytosol The directed movement of L-cystine from the lysosomal lumen across the lysosomal membrane and into the cytosol. got7fsn_ti kmv 2016-01-21T16:28:02Z biological_process owl:Class
GO:1903563 biolink:NamedThing microtubule bundle formation involved in horsetail-astral microtubule organization Any microtubule bundle formation that is involved in horsetail-astral microtubule organization. got7fsn_ti microtubule bundling involved in horsetail-astral microtubule organization|microtubule bundling involved in horsetail-astral microtubule array organization|microtubule bundle formation involved in horsetail-astral microtubule array organization|microtubule bundle formation involved in horsetail-astral microtubule organisation|microtubule bundling involved in horsetail-astral microtubule organisation vw 2014-10-23T11:06:35Z biological_process owl:Class
GO:1903585 biolink:NamedThing negative regulation of histone deubiquitination Any process that stops, prevents or reduces the frequency, rate or extent of histone deubiquitination. got7fsn_ti down regulation of histone deubiquitinylation|inhibition of histone deubiquitination|down-regulation of histone deubiquitylation|down-regulation of histone deubiquitination|inhibition of histone deubiquitylation|downregulation of histone deubiquitylation|downregulation of histone deubiquitinylation|downregulation of histone deubiquitination|down-regulation of histone deubiquitinylation|negative regulation of histone deubiquitinylation|negative regulation of histone deubiquitylation|down regulation of histone deubiquitination|inhibition of histone deubiquitinylation|down regulation of histone deubiquitylation lb 2014-11-03T13:47:35Z biological_process owl:Class
GO:1903886 biolink:NamedThing positive regulation of chemokine (C-C motif) ligand 20 production Any process that activates or increases the frequency, rate or extent of chemokine (C-C motif) ligand 20 production. got7fsn_ti up regulation of CCL-20 production|activation of CCL-20 production|up regulation of C-C motif chemokine 20 production|positive regulation of CCL-20 production|activation of C-C motif chemokine 20 production|upregulation of CCL-20 production|upregulation of C-C motif chemokine 20 production|up-regulation of CCL20 production|positive regulation of CCL20 production|up-regulation of C-C motif chemokine 20 production|up-regulation of CCL-20 production|activation of chemokine (C-C motif) ligand 20 production|upregulation of chemokine (C-C motif) ligand 20 production|up regulation of CCL20 production|positive regulation of C-C motif chemokine 20 production|activation of CCL20 production|up-regulation of chemokine (C-C motif) ligand 20 production|up regulation of chemokine (C-C motif) ligand 20 production|upregulation of CCL20 production krc 2015-02-06T16:31:20Z biological_process owl:Class
GO:0140484 biolink:NamedThing 5-aminolevulinic acid import across plasma membrane The directed movement of 5-aminolevulinic acid from outside of a cell, across the plasma membrane and into the cytosol. got7fsn_ti https://github.com/geneontology/go-ontology/issues/19527 pg 2020-06-29T08:59:24Z biological_process owl:Class
GO:0046345 biolink:NamedThing abscisic acid catabolic process The chemical reactions and pathways resulting in the breakdown of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. got7fsn_ti abscisic acid degradation|abscisic acid breakdown|abscisic acid catabolism biological_process owl:Class
GO:1905953 biolink:NamedThing negative regulation of lipid localization Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization. got7fsn_ti down-regulation of lipid localisation|negative regulation of lipid localisation|inhibition of lipid localization|down regulation of lipid localisation|downregulation of lipid localisation|inhibition of lipid localisation|down regulation of lipid localization|down-regulation of lipid localization|downregulation of lipid localization rz 2017-02-21T12:12:41Z biological_process owl:Class
GO:1900851 biolink:NamedThing positive regulation of pseurotin A biosynthetic process Any process that activates or increases the frequency, rate or extent of pseurotin A biosynthetic process. got7fsn_ti upregulation of pseurotin A biosynthetic process|up-regulation of pseurotin A biosynthetic process|up regulation of pseurotin A biosynthetic process di 2012-06-07T09:45:56Z biological_process owl:Class
GO:1905001 biolink:NamedThing negative regulation of membrane repolarization during atrial cardiac muscle cell action potential Any process that stops, prevents or reduces the frequency, rate or extent of membrane repolarization during atrial cardiac muscle cell action potential. got7fsn_ti downregulation of membrane repolarization during atrial cardiac muscle cell action potential|downregulation of electrocardiogram QRS complex|down-regulation of electrocardiogram QRS complex|down-regulation of membrane repolarization during atrial cardiac muscle cell action potential|negative regulation of electrocardiogram QRS complex|inhibition of electrocardiogram QRS complex|down-regulation of atrial repolarization|negative regulation of atrial repolarization|inhibition of atrial repolarization|down regulation of membrane repolarization during atrial cardiac muscle cell action potential|down regulation of atrial repolarization|downregulation of atrial repolarization|down regulation of electrocardiogram QRS complex|inhibition of membrane repolarization during atrial cardiac muscle cell action potential rph 2016-03-01T13:28:13Z biological_process owl:Class
GO:0044113 biolink:NamedThing obsolete development in other organism involved in symbiotic interaction OBSOLETE. The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism. got7fsn_ti development in other organism during symbiotic interaction https://github.com/geneontology/go-ontology/issues/20305 This term was obsoleted because it represents both a process and a location. jl 2009-07-30T02:32:38Z True biological_process owl:Class
GO:0031935 biolink:NamedThing obsolete regulation of chromatin silencing OBSOLETE. Any process that affects the rate, extent or location of chromatin silencing. got7fsn_ti regulation of heterochromatic silencing https://github.com/geneontology/go-ontology/issues/22060 This term was obsoleted because it was too vague: regulation of chromatin (gene) silencing takes place via upstream signaling pathways. True biological_process owl:Class
GO:1900948 biolink:NamedThing negative regulation of isoprene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of isoprene biosynthetic process. got7fsn_ti down-regulation of hemiterpene biosynthesis|inhibition of 2-methyl-1,3-butadiene biosynthesis|inhibition of hemiterpene biosynthetic process|down regulation of hemiterpene biosynthesis|negative regulation of 2-methyl-1,3-butadiene biosynthesis|downregulation of hemiterpene biosynthesis|down regulation of hemiterpene biosynthetic process|negative regulation of 2-methyl-1,3-butadiene biosynthetic process|downregulation of 2-methyl-1,3-butadiene biosynthesis|down-regulation of isoprene biosynthetic process|down-regulation of 2-methyl-1,3-butadiene biosynthetic process|down regulation of 2-methyl-1,3-butadiene biosynthesis|inhibition of hemiterpene biosynthesis|down regulation of isoprene biosynthetic process|downregulation of isoprene biosynthetic process|downregulation of hemiterpene biosynthetic process|down-regulation of 2-methyl-1,3-butadiene biosynthesis|downregulation of 2-methyl-1,3-butadiene biosynthetic process|down-regulation of hemiterpene biosynthetic process|inhibition of isoprene biosynthetic process|down regulation of 2-methyl-1,3-butadiene biosynthetic process|inhibition of 2-methyl-1,3-butadiene biosynthetic process|negative regulation of hemiterpene biosynthetic process|negative regulation of hemiterpene biosynthesis tt 2012-06-14T03:21:47Z biological_process owl:Class
GO:1900075 biolink:NamedThing positive regulation of neuromuscular synaptic transmission Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission. got7fsn_ti activation of neuromuscular synaptic transmission|up-regulation of neuromuscular synaptic transmission|upregulation of neuromuscular synaptic transmission|up regulation of neuromuscular synaptic transmission kmv 2012-01-26T10:14:22Z biological_process owl:Class
GO:0043267 biolink:NamedThing negative regulation of potassium ion transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. got7fsn_ti down regulation of potassium ion transport|negative regulation of K+ transport|transmembrane conductance regulator activity|negative regulation of potassium ion conductance|regulation of K+ conductance|downregulation of potassium ion transport|down-regulation of potassium ion transport|inhibition of potassium ion transport|negative regulation of potassium transport|regulation of potassium conductance biological_process owl:Class
GO:1903266 biolink:NamedThing regulation of ornithine catabolic process Any process that modulates the frequency, rate or extent of ornithine catabolic process. got7fsn_ti regulation of ornithine degradation|regulation of ornithine breakdown|regulation of ornithine catabolism An example of this is ARGI in Saccharomyces cerevisiae (P00812) in PMID:12679340 (inferred from direct assay). bhm 2014-08-08T08:29:33Z biological_process owl:Class
GO:0009197 biolink:NamedThing pyrimidine deoxyribonucleoside diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar. got7fsn_ti pyrimidine deoxyribonucleoside diphosphate synthesis|pyrimidine deoxyribonucleoside diphosphate formation|pyrimidine deoxyribonucleoside diphosphate anabolism|pyrimidine deoxyribonucleoside diphosphate biosynthesis biological_process owl:Class
GO:0060759 biolink:NamedThing regulation of response to cytokine stimulus Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus. got7fsn_ti dph 2009-06-22T02:56:12Z biological_process owl:Class
GO:0070964 biolink:NamedThing positive regulation of neutrophil mediated killing of gram-positive bacterium Any process that increases the frequency, rate or extent of the directed killing of a gram-positive bacterium by a neutrophil. got7fsn_ti up-regulation of neutrophil mediated killing of gram-positive bacterium|activation of neutrophil mediated killing of gram-positive bacterium|stimulation of neutrophil mediated killing of gram-positive bacterium|upregulation of neutrophil mediated killing of gram-positive bacterium|up regulation of neutrophil mediated killing of gram-positive bacterium mah 2009-10-01T02:28:49Z biological_process owl:Class
GO:1903450 biolink:NamedThing regulation of G1 to G0 transition Any process that modulates the frequency, rate or extent of G1 to G0 transition. got7fsn_ti regulation of G1/G0 transition|regulation of stationary phase|regulation of cell cycle quiescence|regulation of establishment of cell quiescence di 2014-09-19T22:23:13Z biological_process owl:Class
PR:000002094 biolink:NamedThing got7fsn_ti owl:Class
GO:1900981 biolink:NamedThing negative regulation of phenazine biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of phenazine biosynthetic process. got7fsn_ti down-regulation of dibenzopyrazine biosynthesis|down-regulation of acridizine biosynthetic process|inhibition of dibenzo-p-diazine biosynthesis|down regulation of dibenzo-p-diazine biosynthetic process|negative regulation of azophenylene biosynthetic process|inhibition of phenazine biosynthetic process|down-regulation of azophenylene biosynthesis|downregulation of phenazine biosynthetic process|down regulation of phenazine biosynthetic process|down-regulation of dibenzo-p-diazine biosynthetic process|down regulation of acridizine biosynthesis|downregulation of dibenzo-p-diazine biosynthesis|down-regulation of dibenzopyrazine biosynthetic process|down regulation of dibenzo-p-diazine biosynthesis|downregulation of acridizine biosynthesis|inhibition of dibenzopyrazine biosynthesis|downregulation of dibenzo-p-diazine biosynthetic process|down regulation of dibenzopyrazine biosynthesis|inhibition of acridizine biosynthetic process|downregulation of dibenzopyrazine biosynthetic process|negative regulation of dibenzopyrazine biosynthetic process|inhibition of dibenzo-p-diazine biosynthetic process|down-regulation of dibenzo-p-diazine biosynthesis|downregulation of acridizine biosynthetic process|down regulation of azophenylene biosynthetic process|down-regulation of phenazine biosynthetic process|inhibition of azophenylene biosynthesis|negative regulation of dibenzopyrazine biosynthesis|down regulation of azophenylene biosynthesis|negative regulation of dibenzo-p-diazine biosynthetic process|inhibition of azophenylene biosynthetic process|negative regulation of dibenzo-p-diazine biosynthesis|negative regulation of azophenylene biosynthesis|down-regulation of azophenylene biosynthetic process|inhibition of dibenzopyrazine biosynthetic process|down regulation of dibenzopyrazine biosynthetic process|downregulation of azophenylene biosynthetic process|downregulation of dibenzopyrazine biosynthesis|downregulation of azophenylene biosynthesis|down-regulation of acridizine biosynthesis|down regulation of acridizine biosynthetic process|negative regulation of acridizine biosynthesis|inhibition of acridizine biosynthesis|negative regulation of acridizine biosynthetic process tt 2012-06-14T04:05:03Z biological_process owl:Class
GO:1900951 biolink:NamedThing negative regulation of 18-methylnonadec-1-ene biosynthetic process Any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process. got7fsn_ti down regulation of 18-methylnonadec-1-ene biosynthetic process|down-regulation of 18-methylnonadec-1-ene formation|negative regulation of 18-methylnonadec-1-ene synthesis|downregulation of 18-methylnonadec-1-ene synthesis|downregulation of 18-methylnonadec-1-ene formation|negative regulation of 18-methylnonadec-1-ene formation|negative regulation of 18-methylnonadec-1-ene anabolism|inhibition of 18-methylnonadec-1-ene biosynthesis|downregulation of 18-methylnonadec-1-ene biosynthesis|down regulation of 18-methylnonadec-1-ene anabolism|inhibition of 18-methylnonadec-1-ene synthesis|down regulation of 18-methylnonadec-1-ene synthesis|down-regulation of 18-methylnonadec-1-ene biosynthesis|negative regulation of 18-methylnonadec-1-ene biosynthesis|down-regulation of 18-methylnonadec-1-ene synthesis|inhibition of 18-methylnonadec-1-ene formation|inhibition of 18-methylnonadec-1-ene anabolism|down regulation of 18-methylnonadec-1-ene biosynthesis|down-regulation of 18-methylnonadec-1-ene anabolism|down-regulation of 18-methylnonadec-1-ene biosynthetic process|downregulation of 18-methylnonadec-1-ene biosynthetic process|down regulation of 18-methylnonadec-1-ene formation|downregulation of 18-methylnonadec-1-ene anabolism|inhibition of 18-methylnonadec-1-ene biosynthetic process tt 2012-06-14T03:23:55Z biological_process owl:Class
GO:0052366 biolink:NamedThing obsolete catabolism by organism of xylan in other organism involved in symbiotic interaction OBSOLETE. The chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within a second organism, where the two organisms are in a symbiotic interaction. got7fsn_ti catabolism by organism of xylan in other organism during symbiotic interaction https://github.com/geneontology/go-ontology/issues/21396 This term was obsoleted because it represents an unnecessary grouping class. True biological_process owl:Class
GO:0039543 biolink:NamedThing obsolete suppression by virus of host RIG-I activity by viral RNA 5' processing OBSOLETE. The post-transcriptional removal by a virus of the 5' triphosphate group of their viral RNA, thereby preventing host RIG-I from recognizing viral RNA in the host cell. The intracellular pattern recognition receptor RIG-I (also known as DDX58) recognizes viral RNAs containing 5' triphosphates; removal by the virus of the 5'-terminal triphosphate group from their genome protects the viral RNA from RIG-recognition. got7fsn_ti suppression by virus of host RIG-I activity by inhibition of RNA binding The reason for obsoleting this term is that it is too specific. The exact molecular roles of the individual proteins should be captured separately. bf 2012-01-18T02:30:29Z True biological_process owl:Class
GO:1903554 biolink:NamedThing G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium Any G protein-coupled receptor signaling pathway that is involved in defense response to Gram-negative bacterium. got7fsn_ti G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacteria|G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium|G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium|G-protein coupled receptor protein signal transduction involved in defense response to Gram-negative bacterium|G-protein-coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria|GPCR signalling pathway involved in defense response to Gram-negative bacteria|G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacterium|G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacterium|G protein coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity|G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor signaling pathway involved in Gram-negative antibacterial peptide activity|G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor signaling pathway involved in defense response to Gram-negative bacteria|G-protein-coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium|G-protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium|GPCR signaling pathway involved in defense response to Gram-negative bacteria|GPCR signalling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor protein signal transduction involved in defence response to Gram-negative bacteria|G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacterium|G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria|G-protein coupled receptor signalling pathway involved in defence response to Gram-negative bacterium|G-protein coupled receptor signalling pathway involved in defense response to Gram-negative bacteria|G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacterium|G-protein coupled receptor protein signal transduction involved in Gram-negative antibacterial peptide activity|G-protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium|G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacterium|G-protein-coupled receptor protein signalling pathway involved in Gram-negative antibacterial peptide activity|GPCR signaling pathway involved in defence response to Gram-negative bacteria|G-protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity|G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium|GPCR signaling pathway involved in Gram-negative antibacterial peptide activity|G-protein coupled receptor signaling pathway involved in defence response to Gram-negative bacteria|GPCR signalling pathway involved in defense response to Gram-negative bacterium|GPCR signalling pathway involved in Gram-negative antibacterial peptide activity|G protein coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity|G protein coupled receptor protein signalling pathway involved in defense response to Gram-negative bacteria|GPCR signalling pathway involved in defence response to Gram-negative bacterium|GPCR signaling pathway involved in defence response to Gram-negative bacterium|G-protein-coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria|G protein coupled receptor protein signaling pathway involved in defense response to Gram-negative bacteria|G-protein-coupled receptor protein signaling pathway involved in Gram-negative antibacterial peptide activity|G-protein-coupled receptor protein signaling pathway involved in defense response to Gram-negative bacterium|G protein coupled receptor protein signaling pathway involved in defence response to Gram-negative bacterium|G-protein coupled receptor signalling pathway involved in Gram-negative antibacterial peptide activity|GPCR signaling pathway involved in defense response to Gram-negative bacterium|G protein coupled receptor protein signalling pathway involved in defence response to Gram-negative bacteria kmv 2014-10-20T17:51:13Z biological_process owl:Class
GO:0072368 biolink:NamedThing obsolete regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter OBSOLETE. Any process that modulates the frequency, rate or extent of lipid transport by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter. got7fsn_ti regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter This term was obsoleted because it represents a GO-CAM model. mah 2010-11-16T03:18:13Z True biological_process owl:Class
GO:0051336 biolink:NamedThing regulation of hydrolase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. got7fsn_ti hydrolase regulator biological_process owl:Class
GO:1905559 biolink:NamedThing positive regulation of mitotic nuclear envelope disassembly Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly. got7fsn_ti up-regulation of mitotic nuclear envelope catabolism|activation of mitotic nuclear envelope disassembly|up-regulation of mitotic nuclear envelope breakdown|positive regulation of mitotic nuclear envelope catabolism|upregulation of mitotic nuclear envelope disassembly|up-regulation of mitotic nuclear envelope degradation|up regulation of mitotic nuclear envelope breakdown|up regulation of mitotic nuclear envelope catabolism|activation of mitotic nuclear envelope breakdown|positive regulation of mitotic nuclear envelope degradation|upregulation of mitotic nuclear envelope degradation|up regulation of mitotic nuclear envelope disassembly|activation of mitotic nuclear envelope catabolism|positive regulation of mitotic nuclear envelope breakdown|upregulation of mitotic nuclear envelope catabolism|activation of mitotic nuclear envelope degradation|up-regulation of mitotic nuclear envelope disassembly|up regulation of mitotic nuclear envelope degradation|upregulation of mitotic nuclear envelope breakdown hbye 2016-10-14T13:15:17Z biological_process owl:Class
GO:0009964 biolink:NamedThing negative regulation of flavonoid biosynthetic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids. got7fsn_ti downregulation of flavonoid biosynthetic process|negative regulation of flavonoid biosynthesis|negative regulation of flavonoid formation|negative regulation of flavonoid anabolism|negative regulation of flavonoid synthesis|down regulation of flavonoid biosynthetic process|inhibition of flavonoid biosynthetic process|down-regulation of flavonoid biosynthetic process biological_process owl:Class
GO:2000450 biolink:NamedThing negative regulation of CD8-positive, alpha-beta T cell extravasation Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation. got7fsn_ti bf 2011-03-04T10:41:43Z biological_process owl:Class
GO:0071931 biolink:NamedThing positive regulation of transcription involved in G1/S transition of mitotic cell cycle Any process that activates or increases transcription as part of the G1/S transition of the mitotic cell cycle. got7fsn_ti positive regulation of transcription from RNA polymerase II promoter involved in G1/S transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter during G1/S phase of mitotic cell cycle mah 2010-09-29T11:15:34Z biological_process owl:Class
GO:0003734 biolink:NamedThing obsolete small nuclear ribonucleoprotein OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti small nuclear ribonucleoprotein|snRNP GO:0030532 This term was made obsolete because it describes a cellular component rather than a molecular function. True molecular_function owl:Class
GO:2000518 biolink:NamedThing negative regulation of T-helper 1 cell activation Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation. got7fsn_ti negative regulation of Th1 cell activation ebc 2011-03-22T10:40:26Z biological_process owl:Class
GO:1902553 biolink:NamedThing positive regulation of catalase activity Any process that activates or increases the frequency, rate or extent of catalase activity. got7fsn_ti upregulation of haem catalase activity|positive regulation of heme catalase activity|up regulation of catalase-peroxidase activity|upregulation of manganese catalase activity|activation of bacterial catalase-peroxidase activity|upregulation of optidase activity|up-regulation of caperase activity|up regulation of equilase activity|activation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|up regulation of haem catalase activity|activation of caperase activity|up-regulation of manganese catalase activity|activation of haem catalase activity|upregulation of bacterial catalase-peroxidase activity|positive regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|activation of heme catalase activity|up-regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|upregulation of catalase-peroxidase activity|up-regulation of heme catalase activity|up-regulation of CAT|up-regulation of catalase-peroxidase activity|positive regulation of manganese catalase activity|positive regulation of CAT|positive regulation of optidase activity|positive regulation of bacterial catalase-peroxidase activity|positive regulation of equilase activity|upregulation of caperase activity|activation of equilase activity|activation of catalase activity|up-regulation of equilase activity|up regulation of CAT|up regulation of caperase activity|upregulation of heme catalase activity|up regulation of bacterial catalase-peroxidase activity|up regulation of optidase activity|activation of manganese catalase activity|upregulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|up regulation of catalase activity|activation of optidase activity|upregulation of equilase activity|up-regulation of catalase activity|up regulation of manganese catalase activity|activation of catalase-peroxidase activity|positive regulation of catalase reaction|positive regulation of caperase activity|up-regulation of bacterial catalase-peroxidase activity|up-regulation of optidase activity|positive regulation of haem catalase activity|positive regulation of catalase-peroxidase activity|up-regulation of catalase reaction|up regulation of catalase reaction|activation of CAT|up regulation of hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity|upregulation of catalase activity|up regulation of heme catalase activity|activation of catalase reaction|upregulation of CAT|upregulation of catalase reaction|up-regulation of haem catalase activity tb 2013-12-04T21:56:03Z biological_process owl:Class
GO:0038082 biolink:NamedThing obsolete MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway OBSOLETE. Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway. got7fsn_ti MAPK phosphatase activity involved in regulation of osmosensory signaling pathway|MAP kinase phosphatase activity involved in regulation of osmosensory signalling pathway|Hog1 phosphatase activity This term has been obsoleted because it represents a GO-CAM model rather than a single GO term. bf 2012-01-26T02:41:31Z True molecular_function owl:Class
GO:0051848 biolink:NamedThing obsolete active evasion of symbiont immune response via regulation of symbiont cytokine network OBSOLETE. Any mechanism of active immune avoidance which works by regulating symbiont cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester symbiont cytokines and inhibit action. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction. got7fsn_ti active immune evasion via regulation of symbiont cytokine network|active evasion of symbiont immune response via regulation of symbiont cytokine network|active immune evasion via modulation of symbiont cytokine network This term was made obsolete because it does not represent a real process that exists in nature. True biological_process owl:Class
GO:0004864 biolink:NamedThing protein phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins. got7fsn_ti protein phosphatase type 2A inhibitor activity|phosphoprotein phosphatase inhibitor activity|protein phosphatase 2 inhibitor activity rb 2015-03-03T23:57:25Z GO:1990681 molecular_function owl:Class
GO:1904091 biolink:NamedThing peptidyl carrier protein activity Binding an amino-acid derived peptidyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the peptidyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. Peptidyl carrier protein (PCP) is involved in nonribosomal peptide biosynthetic process. got7fsn_ti oligopeptides binding involved in nonribosomal peptide biosynthetic process|peptidyl binding involved in nonribosomal peptide biosynthesis|PCP|oligopeptide binding involved in non-ribosomal peptide formation|oligopeptides binding involved in non-ribosomal peptide biosynthesis|oligopeptido binding involved in non-ribosomal peptide biosynthesis|Oligopeptid binding involved in nonribosomal peptide synthesis|Oligopeptid binding involved in non-ribosomal peptide synthesis|peptidyl binding involved in nonribosomal peptide biosynthetic process|oligopeptido binding involved in non-ribosomal peptide synthesis|oligopeptides binding involved in nonribosomal peptide biosynthesis|oligopeptide binding involved in non-ribosomal peptide synthesis|Oligopeptid binding involved in non-ribosomal peptide formation|oligopeptides binding involved in non-ribosomal peptide biosynthetic process|Oligopeptid binding involved in nonribosomal peptide anabolism|oligopeptido binding involved in nonribosomal peptide synthesis|oligopeptide binding involved in nonribosomal peptide biosynthesis|oligopeptido binding involved in non-ribosomal peptide biosynthetic process|oligopeptides binding involved in nonribosomal peptide synthesis|Oligopeptid binding involved in nonribosomal peptide biosynthesis|oligopeptides binding involved in nonribosomal peptide synthetase|oligopeptides binding involved in nonribosomal peptide formation|oligopeptido binding involved in nonribosomal peptide biosynthetic process|Oligopeptid binding involved in non-ribosomal peptide biosynthesis|oligopeptido binding involved in nonribosomal peptide anabolism|oligopeptide binding involved in nonribosomal peptide synthetase|Oligopeptid binding involved in nonribosomal peptide synthetase|peptidyl carrier protein|oligopeptide binding involved in nonribosomal peptide formation|Oligopeptid binding involved in nonribosomal peptide biosynthetic process|peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process|oligopeptide binding involved in non-ribosomal peptide biosynthesis|peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis|oligopeptide binding involved in nonribosomal peptide biosynthetic process|oligopeptide binding involved in non-ribosomal peptide biosynthetic process|Oligopeptid binding involved in non-ribosomal peptide biosynthetic process|oligopeptides binding involved in non-ribosomal peptide formation|oligopeptido binding involved in nonribosomal peptide synthetase|oligopeptides binding involved in non-ribosomal peptide synthesis|oligopeptido binding involved in nonribosomal peptide formation|oligopeptide binding involved in nonribosomal peptide synthesis|Oligopeptid binding involved in nonribosomal peptide formation|oligopeptide binding involved in nonribosomal peptide anabolism|oligopeptides binding involved in nonribosomal peptide anabolism|oligopeptido binding involved in nonribosomal peptide biosynthesis|oligopeptido binding involved in non-ribosomal peptide formation Examples are the ferrichrome synthetase Sib1 in S. pombe and the peptidyl carrier protein (PCP) module in bacterial nonribosomal peptide synthases (NRPSs), which holds the peptidyl group and acts as a swinging arm, limiting diffusion until the peptide comes into contact with the next enzymatic module in the NRPS process. pr 2015-03-26T10:41:52Z molecular_function owl:Class
GO:0030006 biolink:NamedThing obsolete heavy cellular metal ion homeostasis OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn. got7fsn_ti heavy cellular metal ion homeostasis This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). GO:0006875 True biological_process owl:Class
GO:0007125 biolink:NamedThing obsolete invasive growth OBSOLETE. (Was not defined before being made obsolete). got7fsn_ti invasive growth This term was made obsolete because it has been split into two new terms. GO:0044409|GO:0001403 True biological_process owl:Class
GO:1904471 biolink:NamedThing negative regulation of endothelin production Any process that stops, prevents or reduces the frequency, rate or extent of endothelin production. got7fsn_ti negative regulation of EDN2 secretion|inhibition of EDN3 secretion|negative regulation of endothelin-3 secretion|inhibition of endothelin secretion|downregulation of EDN2 secretion|negative regulation of endothelin-1 secretion|down-regulation of EDN1 secretion|down regulation of EDN1 secretion|downregulation of EDN1 secretion|negative regulation of endothelin-2 secretion|downregulation of endothelin secretion|down regulation of endothelin-2 secretion|down regulation of endothelin-1 secretion|down-regulation of endothelin-1 secretion|negative regulation of EDN3 secretion|down regulation of endothelin-3 secretion|down-regulation of endothelin-2 secretion|down regulation of endothelin secretion|down-regulation of endothelin-3 secretion|down-regulation of EDN3 secretion|down regulation of EDN2 secretion|inhibition of endothelin-2 secretion|down regulation of EDN3 secretion|downregulation of EDN3 secretion|downregulation of endothelin-1 secretion|down-regulation of EDN2 secretion|inhibition of EDN2 secretion|downregulation of endothelin-3 secretion|negative regulation of EDN1 secretion|down-regulation of endothelin secretion|negative regulation of endothelin secretion|inhibition of EDN1 secretion|inhibition of endothelin-3 secretion|inhibition of endothelin-1 secretion|downregulation of endothelin-2 secretion sl 2015-07-09T19:58:03Z biological_process owl:Class
GO:1903392 biolink:NamedThing negative regulation of adherens junction organization Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization. got7fsn_ti downregulation of adherens junction organization|negative regulation of adherens junction organisation|downregulation of adherens junction organisation|down-regulation of adherens junction organization|down-regulation of adherens junction organisation|inhibition of adherens junction organisation|downregulation of adherens junction assembly and maintenance|down regulation of adherens junction organization|negative regulation of adherens junction assembly and maintenance|down regulation of adherens junction assembly and maintenance|down regulation of adherens junction organisation|down-regulation of adherens junction assembly and maintenance|inhibition of adherens junction organization|inhibition of adherens junction assembly and maintenance als 2014-08-27T10:08:47Z biological_process owl:Class
GO:0061188 biolink:NamedThing negative regulation of ribosomal DNA heterochromatin assembly Any process that decreases the rate, frequency, or extent of the repression of assembly of rDNA heterochromatin. got7fsn_ti negative regulation of chromatin silencing at rDNA https://github.com/geneontology/go-ontology/issues/19238 dph 2010-07-14T09:07:59Z biological_process owl:Class
GO:0070438 biolink:NamedThing obsolete mTOR-FKBP12-rapamycin complex OBSOLETE. A protein complex that contains the mTOR (mammalian target of rapamycin) serine/threonine kinase, the peptidyl-prolyl cis-trans isomerase FKBP12 (FKBP1A) and rapamycin (sirolimus). got7fsn_ti Fkbp1a-Frap1 complex|mTOR-FKBP12-rapamycin complex This term was made obsolete because it describes a complex with a drug bound, with the drug being exogenous to the species where the experiment takes place and where that interaction would never occur naturally. True cellular_component owl:Class
GO:1903783 biolink:NamedThing negative regulation of sodium ion import across plasma membrane Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion import across the plasma membrane. got7fsn_ti inhibition of sodium ion import across plasma membrane|downregulation of sodium ion import across plasma membrane|down regulation of sodium ion import across plasma membrane|down-regulation of sodium ion import across plasma membrane nc 2015-01-07T16:48:51Z biological_process owl:Class
GO:0106057 biolink:NamedThing negative regulation of calcineurin-mediated signaling Any process that stops, prevents or reduces the frequency, rate or extent of calcineurin-mediated signalling. got7fsn_ti hjd 2017-09-18T16:50:11Z biological_process owl:Class
GO:0043275 biolink:NamedThing obsolete glutamate carboxypeptidase II activity OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu. got7fsn_ti pteroylpolygammaglutamyl hydrolase activity|folate hydrolase activity|N-acetylated-gamma-linked-acidic dipeptidase activity|glutamate carboxypeptidase II activity|microsomal gamma-glutamyl carboxypeptidase|pteroylpolyglutamic acid hydrolase activity|NAALADase activity|N-acetylated-gamma-linked-acidic dipeptidase (NAALADase)|membrane glutamate carboxypeptidase|folylpolyglutamate hydrolase activity|NAALA dipeptidase activity|PSMA|pteroylpoly-gamma-glutamate carboxypeptidase activity|rat NAAG peptidase|prostrate-specific membrane antigen|mGCP|pteroylpoly-gamma-glutamate hydrolase activity|N-acetylated-alpha-linked-amino dipeptidase activity|N-acetylated alpha-linked acidic dipeptidase activity|prostate-specific membrane antigen|acetylaspartylglutamate dipeptidase activity|pteroylpolyglutamate hydrolase activity|PSM antigen GO:0004181 This term was made obsolete because it represents a gene product. True molecular_function owl:Class
GO:0042361 biolink:NamedThing menaquinone catabolic process The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. got7fsn_ti menaquinone breakdown|menatetrenone catabolism|vitamin K2 catabolic process|menaquinone degradation|menaquinone catabolism|multiprenylmenaquinone catabolic process|menatetrenone catabolic process|vitamin K2 catabolism|multiprenylmenaquinone catabolism biological_process owl:Class
GO:2000208 biolink:NamedThing positive regulation of ribosomal small subunit export from nucleus Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus. got7fsn_ti positive regulation of ribosomal small subunit-nucleus export|positive regulation of ribosomal small subunit transport from nucleus to cytoplasm|positive regulation of ribosomal small subunit export out of nucleus|positive regulation of ribosomal small subunit export from cell nucleus|positive regulation of 30S ribosomal subunit export from nucleus|positive regulation of 40S ribosomal subunit export from nucleus mah 2010-10-26T10:54:16Z biological_process owl:Class
GO:1904293 biolink:NamedThing negative regulation of ERAD pathway Any process that stops, prevents or reduces the frequency, rate or extent of ERAD pathway. got7fsn_ti downregulation of endoplasmic reticulum-associated protein degradation pathway|downregulation of endoplasmic reticulum-associated degradation|down regulation of endoplasmic reticulum-associated